Search of human proteins with 117968621

Search of human proteins with 117968621

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|117968621 MACRO domain containing 2 isoform 1 [Homo sapiens]
         (425 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|117968621 MACRO domain containing 2 isoform 1 [Homo sapiens]       865   0.0  
gi|74325776 MACRO domain containing 2 isoform 2 [Homo sapiens]        372   e-103
gi|13569840 MACRO domain containing 1 [Homo sapiens]                  249   3e-66
gi|207450721 ganglioside induced differentiation associated prot...   120   2e-27
gi|8923143 ganglioside induced differentiation associated protei...   120   2e-27
gi|154813199 poly (ADP-ribose) polymerase family, member 14 [Hom...    75   1e-13
gi|20336746 H2A histone family, member Y isoform 1 [Homo sapiens]      74   3e-13
gi|226371718 poly (ADP-ribose) polymerase family, member 9 isofo...    67   2e-11
gi|226371716 poly (ADP-ribose) polymerase family, member 9 isofo...    67   2e-11
gi|226371714 poly (ADP-ribose) polymerase family, member 9 isofo...    67   2e-11
gi|226371712 poly (ADP-ribose) polymerase family, member 9 isofo...    67   2e-11
gi|226371710 poly (ADP-ribose) polymerase family, member 9 isofo...    67   2e-11
gi|226371706 poly (ADP-ribose) polymerase family, member 9 isofo...    67   2e-11
gi|4758496 H2A histone family, member Y isoform 2 [Homo sapiens]       67   3e-11
gi|93141020 H2A histone family, member Y isoform 2 [Homo sapiens]      67   3e-11
gi|93141018 H2A histone family, member Y isoform 3 [Homo sapiens]      67   3e-11
gi|165377137 poly (ADP-ribose) polymerase family, member 15 isof...    60   4e-09
gi|24415404 MDN1, midasin homolog [Homo sapiens]                       59   1e-08
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              50   4e-06
gi|210032580 SET domain containing 1B [Homo sapiens]                   50   4e-06
gi|13540523 nucleosomal binding protein 1 [Homo sapiens]               49   9e-06
gi|46409304 glutamate-rich 1 [Homo sapiens]                            49   9e-06
gi|21735569 claspin [Homo sapiens]                                     49   1e-05
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     48   2e-05
gi|4504487 histidine rich calcium binding protein precursor [Hom...    48   2e-05
gi|155030232 proline, glutamic acid and leucine rich protein 1 [...    47   3e-05
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    47   3e-05
gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1 precu...    47   3e-05
gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2 pre...    47   3e-05
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    47   3e-05

>gi|117968621 MACRO domain containing 2 isoform 1 [Homo sapiens]
          Length = 425

 Score =  865 bits (2235), Expect = 0.0
 Identities = 425/425 (100%), Positives = 425/425 (100%)

Query: 1   MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQE 60
           MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQE
Sbjct: 1   MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQE 60

Query: 61  TSQVKKSLTEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRNL 120
           TSQVKKSLTEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRNL
Sbjct: 61  TSQVKKSLTEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRNL 120

Query: 121 NGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSV 180
           NGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSV
Sbjct: 121 NGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSV 180

Query: 181 AFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIYKKKMNEFF 240
           AFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIYKKKMNEFF
Sbjct: 181 AFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIYKKKMNEFF 240

Query: 241 SVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCK 300
           SVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCK
Sbjct: 241 SVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCK 300

Query: 301 DEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQE 360
           DEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQE
Sbjct: 301 DEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQE 360

Query: 361 DAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDEAKEQ 420
           DAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDEAKEQ
Sbjct: 361 DAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDEAKEQ 420

Query: 421 RNGTK 425
           RNGTK
Sbjct: 421 RNGTK 425


>gi|74325776 MACRO domain containing 2 isoform 2 [Homo sapiens]
          Length = 213

 Score =  372 bits (955), Expect = e-103
 Identities = 190/213 (89%), Positives = 190/213 (89%), Gaps = 23/213 (10%)

Query: 236 MNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEA 295
           MNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEA
Sbjct: 1   MNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEA 60

Query: 296 VEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEEL 355
           VEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEEL
Sbjct: 61  VEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEEL 120

Query: 356 SSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPD----- 410
           SSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPD     
Sbjct: 121 SSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDVEMNS 180

Query: 411 ------------------AGAQDEAKEQRNGTK 425
                             AGAQDEAKEQRNGTK
Sbjct: 181 QVDKVNDPTESQQEDQLIAGAQDEAKEQRNGTK 213


>gi|13569840 MACRO domain containing 1 [Homo sapiens]
          Length = 325

 Score =  249 bits (636), Expect = 3e-66
 Identities = 129/233 (55%), Positives = 161/233 (69%), Gaps = 4/233 (1%)

Query: 11  WREEKERLLKMTLEERRKEYL-RDYIPLNSILSWKEEMKGKGQNDEENTQETSQVKKSLT 69
           W+E K  L  ++ ++R + Y  +D++ L  I +WKE  KG     EE   +     K L 
Sbjct: 95  WKEAKSFLKGLSDKQREEHYFCKDFVRLKKIPTWKEMAKGVAVKVEEPRYKKD---KQLN 151

Query: 70  EKVSLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCDTGHAK 129
           EK+SL R DIT LEVDAIVNAAN+SLLGGGGVDGCIHRAAGP L  ECR L  C TG AK
Sbjct: 152 EKISLLRSDITKLEVDAIVNAANSSLLGGGGVDGCIHRAAGPLLTDECRTLQSCKTGKAK 211

Query: 130 ITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSVAFPCISTGI 189
           IT GY LPAKYVIHTVGPIA G  + S   +L +CY SSL L+ E+ +RSVAFPCISTG+
Sbjct: 212 ITGGYRLPAKYVIHTVGPIAYGEPSASQAAELRSCYLSSLDLLLEHRLRSVAFPCISTGV 271

Query: 190 YGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIYKKKMNEFFSV 242
           +G+P E AA I L T++EWL ++  +VDR+I CVFLE D  IY+ ++  +F V
Sbjct: 272 FGYPCEAAAEIVLATLREWLEQHKDKVDRLIICVFLEKDEDIYRSRLPHYFPV 324


>gi|207450721 ganglioside induced differentiation associated protein
           2 isoform b [Homo sapiens]
          Length = 496

 Score =  120 bits (302), Expect = 2e-27
 Identities = 79/264 (29%), Positives = 131/264 (49%), Gaps = 27/264 (10%)

Query: 34  YIPLNSILSWKEEMKGKGQNDEENTQETSQ---------VKKSLTEKVSLYRGDITLLEV 84
           ++ ++++ SW +  + +  N  + T E  Q           K +  KV L++GD+ LL  
Sbjct: 10  FVDVDTLPSWGDSCQDE-LNSSDTTAEIFQEDTVRSPFLYNKDVNGKVVLWKGDVALLNC 68

Query: 85  DAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCDTGHAKITCGYDLPAKYVIHT 144
            AIVN +N SL     V   I   AGP L  + + L GC TG AK+T G++L A+++IHT
Sbjct: 69  TAIVNTSNESLTDKNPVSESIFMLAGPDLKEDLQKLKGCRTGEAKLTKGFNLAARFIIHT 128

Query: 145 VGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSVAFPCISTGIYGFPNEPAAVIALNT 204
           VGP  +     + +  L +CY++ L+L KE ++ SV F  I++   G+P E A  IAL T
Sbjct: 129 VGPKYKSRYRTAAESSLYSCYRNVLQLAKEQSMSSVGFCVINSAKRGYPLEDATHIALRT 188

Query: 205 IKEWLAKNHHEVDRIIFCV----------FLEVDFKIYKKKMNE---FFSVDDNNEEEED 251
           ++ +L  +   +++++F V           L + F    K+ N    +   D  N E E 
Sbjct: 189 VRRFLEIHGETIEKVVFAVSDLEEGTYQKLLPLYFPRSLKEENRSLPYLPADIGNAEGEP 248

Query: 252 V----EMKEDSDENGPEEKQSVEE 271
           V    +++       PE+ Q  E+
Sbjct: 249 VVPERQIRISEKPGAPEDNQEEED 272


>gi|8923143 ganglioside induced differentiation associated protein 2
           isoform a [Homo sapiens]
          Length = 497

 Score =  120 bits (302), Expect = 2e-27
 Identities = 79/264 (29%), Positives = 131/264 (49%), Gaps = 27/264 (10%)

Query: 34  YIPLNSILSWKEEMKGKGQNDEENTQETSQ---------VKKSLTEKVSLYRGDITLLEV 84
           ++ ++++ SW +  + +  N  + T E  Q           K +  KV L++GD+ LL  
Sbjct: 10  FVDVDTLPSWGDSCQDE-LNSSDTTAEIFQEDTVRSPFLYNKDVNGKVVLWKGDVALLNC 68

Query: 85  DAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCDTGHAKITCGYDLPAKYVIHT 144
            AIVN +N SL     V   I   AGP L  + + L GC TG AK+T G++L A+++IHT
Sbjct: 69  TAIVNTSNESLTDKNPVSESIFMLAGPDLKEDLQKLKGCRTGEAKLTKGFNLAARFIIHT 128

Query: 145 VGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSVAFPCISTGIYGFPNEPAAVIALNT 204
           VGP  +     + +  L +CY++ L+L KE ++ SV F  I++   G+P E A  IAL T
Sbjct: 129 VGPKYKSRYRTAAESSLYSCYRNVLQLAKEQSMSSVGFCVINSAKRGYPLEDATHIALRT 188

Query: 205 IKEWLAKNHHEVDRIIFCV----------FLEVDFKIYKKKMNE---FFSVDDNNEEEED 251
           ++ +L  +   +++++F V           L + F    K+ N    +   D  N E E 
Sbjct: 189 VRRFLEIHGETIEKVVFAVSDLEEGTYQKLLPLYFPRSLKEENRSLPYLPADIGNAEGEP 248

Query: 252 V----EMKEDSDENGPEEKQSVEE 271
           V    +++       PE+ Q  E+
Sbjct: 249 VVPERQIRISEKPGAPEDNQEEED 272


>gi|154813199 poly (ADP-ribose) polymerase family, member 14 [Homo
           sapiens]
          Length = 1801

 Score = 74.7 bits (182), Expect = 1e-13
 Identities = 48/136 (35%), Positives = 71/136 (52%), Gaps = 4/136 (2%)

Query: 76  RGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCD----TGHAKIT 131
           +GD+  L VD +VNA+N  L   GG+   + +AAGP L A+C  +   +     G+A I+
Sbjct: 808 QGDLARLPVDVVVNASNEDLKHYGGLAAALSKAAGPELQADCDQIVKREGRLLPGNATIS 867

Query: 132 CGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSVAFPCISTGIYG 191
               LP  +VIH VGP   G+        L    + SL L ++   RS+A P IS+G++G
Sbjct: 868 KAGKLPYHHVIHAVGPRWSGYEAPRCVYLLRRAVQLSLCLAEKYKYRSIAIPAISSGVFG 927

Query: 192 FPNEPAAVIALNTIKE 207
           FP        ++ IKE
Sbjct: 928 FPLGRCVETIVSAIKE 943



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 41/161 (25%), Positives = 74/161 (45%), Gaps = 9/161 (5%)

Query: 60   ETSQVKKSLTE----KVSLYRGDITLLEVDAIVNAANASL-LGGGGVDGCIHRAAGPCLL 114
            +TS  K SL      ++ L +  +   + D +VN+    L L  G +   +   AGP L 
Sbjct: 1000 KTSWEKGSLVSPGGLQMLLVKEGVQNAKTDVVVNSVPLDLVLSRGPLSKSLLEKAGPELQ 1059

Query: 115  AECRNLN---GCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKL 171
             E   +        G    T  ++L  +YV+H V P  R     S K  + +  +  +++
Sbjct: 1060 EELDTVGQGVAVSMGTVLKTSSWNLDCRYVLHVVAPEWRNGSTSSLKI-MEDIIRECMEI 1118

Query: 172  VKENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKN 212
             +  +++S+AFP I TG  GFP    A + ++ + ++ +KN
Sbjct: 1119 TESLSLKSIAFPAIGTGNLGFPKNIFAELIISEVFKFSSKN 1159



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 41/163 (25%), Positives = 66/163 (40%), Gaps = 12/163 (7%)

Query: 77   GDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCDTGHAKITCGYDL 136
            GDIT  E D IVN+ + S     GV   I   AG  +  EC            IT G  L
Sbjct: 1234 GDITKEEADVIVNSTSNSFNLKAGVSKAILECAGQNVERECSQQAQQRKNDYIITGGGFL 1293

Query: 137  PAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSVAFPCISTGIYGFPNEP 196
              K +IH +G             D+ +   S L+  ++ N  S+  P I TG      + 
Sbjct: 1294 RCKNIIHVIG-----------GNDVKSSVSSVLQECEKKNYSSICLPAIGTGNAKQHPDK 1342

Query: 197  AAVIALNTIKEWLAK-NHHEVDRIIFCVFLEVDFKIYKKKMNE 238
             A   ++ I++++ K +   V ++   +FL     ++   M +
Sbjct: 1343 VAEAIIDAIEDFVQKGSAQSVKKVKVVIFLPQVLDVFYANMKK 1385


>gi|20336746 H2A histone family, member Y isoform 1 [Homo sapiens]
          Length = 369

 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 51/176 (28%), Positives = 83/176 (47%), Gaps = 12/176 (6%)

Query: 68  LTEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLA---ECRNLNG-C 123
           L +K+ + + DI  ++ DA+V+  N     GG V   + +  G   +    E R  NG  
Sbjct: 193 LGQKLQVVQADIASIDSDAVVHPTNTDFYIGGEVGNTLEKKGGKEFVEAVLELRKKNGPL 252

Query: 124 DTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHK--EDLANCYKSSLKLVKENNIRSVA 181
           +   A ++ G+ LPAK+VIH   P+      G+ K  E L    K+ L L  +  ++S+A
Sbjct: 253 EVAGAAVSAGHGLPAKFVIHCNSPVW-----GADKCEELLEKTVKNCLALADDKKLKSIA 307

Query: 182 FPCISTGIYGFPNEPAAVIALNTIKEWLAKN-HHEVDRIIFCVFLEVDFKIYKKKM 236
           FP I +G  GFP + AA + L  I  +        +  + F +F      IY ++M
Sbjct: 308 FPSIGSGRNGFPKQTAAQLILKAISSYFVSTMSSSIKTVYFVLFDSESIGIYVQEM 363


>gi|226371718 poly (ADP-ribose) polymerase family, member 9 isoform
           c [Homo sapiens]
          Length = 710

 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 50/160 (31%), Positives = 75/160 (46%), Gaps = 8/160 (5%)

Query: 55  EENTQETSQVKKSLTEKV--SLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPC 112
           E N++     +K LT ++  S+++ D+T   VDA+VNAAN  LL GGG+   + +A G  
Sbjct: 66  EGNSKSLQVFRKMLTPRIELSVWKDDLTTHAVDAVVNAANEDLLHGGGLALALVKAGGFE 125

Query: 113 LLAECRNL----NGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSS 168
           +  E +           G   +T    LP K +IH VGP             L     S 
Sbjct: 126 IQEESKQFVARYGKVSAGEIAVTGAGRLPCKQIIHAVGPRWMEWDKQGCTGKLQRAIVSI 185

Query: 169 LKLV--KENNIRSVAFPCISTGIYGFPNEPAAVIALNTIK 206
           L  V  K  +I++VA P +S+GI+ FP        + TI+
Sbjct: 186 LNYVIYKNTHIKTVAIPALSSGIFQFPLNLCTKTIVETIR 225



 Score = 55.5 bits (132), Expect = 9e-08
 Identities = 63/245 (25%), Positives = 103/245 (42%), Gaps = 23/245 (9%)

Query: 45  EEMKGKGQNDEENTQE-TSQVKKSLTEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDG 103
           E + GK +  +E T    + V  +LT  + + +G I     D IVN+ N   +  G V  
Sbjct: 258 EFILGKSELGQETTPSFNAMVVNNLT--LQIVQGHIEWQTADVIVNSVNPHDITVGPVAK 315

Query: 104 CIHRAAGPCLLAECRNLNGCDTGHAK---ITCGYDLPAKYVIHTVGPIARGHINGSHKED 160
            I + AG  + +E           ++   +T G++L  KY+ H +      H      + 
Sbjct: 316 SILQQAGVEMKSEFLATKAKQFQRSQLVLVTKGFNLFCKYIYHVLW-----HSEFPKPQI 370

Query: 161 LANCYKSSLKLVKENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRII 220
           L +  K  L+   E NI S++FP + TG      E AA I  + +  + AK+H +    +
Sbjct: 371 LKHAMKECLEKCIEQNITSISFPALGTGNMEIKKETAAEILFDEVLTF-AKDHVKHQLTV 429

Query: 221 FCVFLEVDFKIYK---KKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQ--------SV 269
             V    D +IYK    +M +   +   N        +E+  ENG E +         +V
Sbjct: 430 KFVIFPTDLEIYKAFSSEMAKRSKMLSLNNYSVPQSTREEKRENGLEARSPAINLMGFNV 489

Query: 270 EEMEE 274
           EEM E
Sbjct: 490 EEMYE 494


>gi|226371716 poly (ADP-ribose) polymerase family, member 9 isoform
           b [Homo sapiens]
          Length = 819

 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 50/160 (31%), Positives = 75/160 (46%), Gaps = 8/160 (5%)

Query: 55  EENTQETSQVKKSLTEKV--SLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPC 112
           E N++     +K LT ++  S+++ D+T   VDA+VNAAN  LL GGG+   + +A G  
Sbjct: 66  EGNSKSLQVFRKMLTPRIELSVWKDDLTTHAVDAVVNAANEDLLHGGGLALALVKAGGFE 125

Query: 113 LLAECRNL----NGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSS 168
           +  E +           G   +T    LP K +IH VGP             L     S 
Sbjct: 126 IQEESKQFVARYGKVSAGEIAVTGAGRLPCKQIIHAVGPRWMEWDKQGCTGKLQRAIVSI 185

Query: 169 LKLV--KENNIRSVAFPCISTGIYGFPNEPAAVIALNTIK 206
           L  V  K  +I++VA P +S+GI+ FP        + TI+
Sbjct: 186 LNYVIYKNTHIKTVAIPALSSGIFQFPLNLCTKTIVETIR 225



 Score = 55.5 bits (132), Expect = 9e-08
 Identities = 63/245 (25%), Positives = 103/245 (42%), Gaps = 23/245 (9%)

Query: 45  EEMKGKGQNDEENTQE-TSQVKKSLTEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDG 103
           E + GK +  +E T    + V  +LT  + + +G I     D IVN+ N   +  G V  
Sbjct: 258 EFILGKSELGQETTPSFNAMVVNNLT--LQIVQGHIEWQTADVIVNSVNPHDITVGPVAK 315

Query: 104 CIHRAAGPCLLAECRNLNGCDTGHAK---ITCGYDLPAKYVIHTVGPIARGHINGSHKED 160
            I + AG  + +E           ++   +T G++L  KY+ H +      H      + 
Sbjct: 316 SILQQAGVEMKSEFLATKAKQFQRSQLVLVTKGFNLFCKYIYHVLW-----HSEFPKPQI 370

Query: 161 LANCYKSSLKLVKENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRII 220
           L +  K  L+   E NI S++FP + TG      E AA I  + +  + AK+H +    +
Sbjct: 371 LKHAMKECLEKCIEQNITSISFPALGTGNMEIKKETAAEILFDEVLTF-AKDHVKHQLTV 429

Query: 221 FCVFLEVDFKIYK---KKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQ--------SV 269
             V    D +IYK    +M +   +   N        +E+  ENG E +         +V
Sbjct: 430 KFVIFPTDLEIYKAFSSEMAKRSKMLSLNNYSVPQSTREEKRENGLEARSPAINLMGFNV 489

Query: 270 EEMEE 274
           EEM E
Sbjct: 490 EEMYE 494


>gi|226371714 poly (ADP-ribose) polymerase family, member 9 isoform
           b [Homo sapiens]
          Length = 819

 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 50/160 (31%), Positives = 75/160 (46%), Gaps = 8/160 (5%)

Query: 55  EENTQETSQVKKSLTEKV--SLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPC 112
           E N++     +K LT ++  S+++ D+T   VDA+VNAAN  LL GGG+   + +A G  
Sbjct: 66  EGNSKSLQVFRKMLTPRIELSVWKDDLTTHAVDAVVNAANEDLLHGGGLALALVKAGGFE 125

Query: 113 LLAECRNL----NGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSS 168
           +  E +           G   +T    LP K +IH VGP             L     S 
Sbjct: 126 IQEESKQFVARYGKVSAGEIAVTGAGRLPCKQIIHAVGPRWMEWDKQGCTGKLQRAIVSI 185

Query: 169 LKLV--KENNIRSVAFPCISTGIYGFPNEPAAVIALNTIK 206
           L  V  K  +I++VA P +S+GI+ FP        + TI+
Sbjct: 186 LNYVIYKNTHIKTVAIPALSSGIFQFPLNLCTKTIVETIR 225



 Score = 55.5 bits (132), Expect = 9e-08
 Identities = 63/245 (25%), Positives = 103/245 (42%), Gaps = 23/245 (9%)

Query: 45  EEMKGKGQNDEENTQE-TSQVKKSLTEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDG 103
           E + GK +  +E T    + V  +LT  + + +G I     D IVN+ N   +  G V  
Sbjct: 258 EFILGKSELGQETTPSFNAMVVNNLT--LQIVQGHIEWQTADVIVNSVNPHDITVGPVAK 315

Query: 104 CIHRAAGPCLLAECRNLNGCDTGHAK---ITCGYDLPAKYVIHTVGPIARGHINGSHKED 160
            I + AG  + +E           ++   +T G++L  KY+ H +      H      + 
Sbjct: 316 SILQQAGVEMKSEFLATKAKQFQRSQLVLVTKGFNLFCKYIYHVLW-----HSEFPKPQI 370

Query: 161 LANCYKSSLKLVKENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRII 220
           L +  K  L+   E NI S++FP + TG      E AA I  + +  + AK+H +    +
Sbjct: 371 LKHAMKECLEKCIEQNITSISFPALGTGNMEIKKETAAEILFDEVLTF-AKDHVKHQLTV 429

Query: 221 FCVFLEVDFKIYK---KKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQ--------SV 269
             V    D +IYK    +M +   +   N        +E+  ENG E +         +V
Sbjct: 430 KFVIFPTDLEIYKAFSSEMAKRSKMLSLNNYSVPQSTREEKRENGLEARSPAINLMGFNV 489

Query: 270 EEMEE 274
           EEM E
Sbjct: 490 EEMYE 494


>gi|226371712 poly (ADP-ribose) polymerase family, member 9 isoform
           b [Homo sapiens]
          Length = 819

 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 50/160 (31%), Positives = 75/160 (46%), Gaps = 8/160 (5%)

Query: 55  EENTQETSQVKKSLTEKV--SLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPC 112
           E N++     +K LT ++  S+++ D+T   VDA+VNAAN  LL GGG+   + +A G  
Sbjct: 66  EGNSKSLQVFRKMLTPRIELSVWKDDLTTHAVDAVVNAANEDLLHGGGLALALVKAGGFE 125

Query: 113 LLAECRNL----NGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSS 168
           +  E +           G   +T    LP K +IH VGP             L     S 
Sbjct: 126 IQEESKQFVARYGKVSAGEIAVTGAGRLPCKQIIHAVGPRWMEWDKQGCTGKLQRAIVSI 185

Query: 169 LKLV--KENNIRSVAFPCISTGIYGFPNEPAAVIALNTIK 206
           L  V  K  +I++VA P +S+GI+ FP        + TI+
Sbjct: 186 LNYVIYKNTHIKTVAIPALSSGIFQFPLNLCTKTIVETIR 225



 Score = 55.5 bits (132), Expect = 9e-08
 Identities = 63/245 (25%), Positives = 103/245 (42%), Gaps = 23/245 (9%)

Query: 45  EEMKGKGQNDEENTQE-TSQVKKSLTEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDG 103
           E + GK +  +E T    + V  +LT  + + +G I     D IVN+ N   +  G V  
Sbjct: 258 EFILGKSELGQETTPSFNAMVVNNLT--LQIVQGHIEWQTADVIVNSVNPHDITVGPVAK 315

Query: 104 CIHRAAGPCLLAECRNLNGCDTGHAK---ITCGYDLPAKYVIHTVGPIARGHINGSHKED 160
            I + AG  + +E           ++   +T G++L  KY+ H +      H      + 
Sbjct: 316 SILQQAGVEMKSEFLATKAKQFQRSQLVLVTKGFNLFCKYIYHVLW-----HSEFPKPQI 370

Query: 161 LANCYKSSLKLVKENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRII 220
           L +  K  L+   E NI S++FP + TG      E AA I  + +  + AK+H +    +
Sbjct: 371 LKHAMKECLEKCIEQNITSISFPALGTGNMEIKKETAAEILFDEVLTF-AKDHVKHQLTV 429

Query: 221 FCVFLEVDFKIYK---KKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQ--------SV 269
             V    D +IYK    +M +   +   N        +E+  ENG E +         +V
Sbjct: 430 KFVIFPTDLEIYKAFSSEMAKRSKMLSLNNYSVPQSTREEKRENGLEARSPAINLMGFNV 489

Query: 270 EEMEE 274
           EEM E
Sbjct: 490 EEMYE 494


>gi|226371710 poly (ADP-ribose) polymerase family, member 9 isoform
           a [Homo sapiens]
          Length = 854

 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 50/160 (31%), Positives = 75/160 (46%), Gaps = 8/160 (5%)

Query: 55  EENTQETSQVKKSLTEKV--SLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPC 112
           E N++     +K LT ++  S+++ D+T   VDA+VNAAN  LL GGG+   + +A G  
Sbjct: 101 EGNSKSLQVFRKMLTPRIELSVWKDDLTTHAVDAVVNAANEDLLHGGGLALALVKAGGFE 160

Query: 113 LLAECRNL----NGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSS 168
           +  E +           G   +T    LP K +IH VGP             L     S 
Sbjct: 161 IQEESKQFVARYGKVSAGEIAVTGAGRLPCKQIIHAVGPRWMEWDKQGCTGKLQRAIVSI 220

Query: 169 LKLV--KENNIRSVAFPCISTGIYGFPNEPAAVIALNTIK 206
           L  V  K  +I++VA P +S+GI+ FP        + TI+
Sbjct: 221 LNYVIYKNTHIKTVAIPALSSGIFQFPLNLCTKTIVETIR 260



 Score = 55.5 bits (132), Expect = 9e-08
 Identities = 63/245 (25%), Positives = 103/245 (42%), Gaps = 23/245 (9%)

Query: 45  EEMKGKGQNDEENTQE-TSQVKKSLTEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDG 103
           E + GK +  +E T    + V  +LT  + + +G I     D IVN+ N   +  G V  
Sbjct: 293 EFILGKSELGQETTPSFNAMVVNNLT--LQIVQGHIEWQTADVIVNSVNPHDITVGPVAK 350

Query: 104 CIHRAAGPCLLAECRNLNGCDTGHAK---ITCGYDLPAKYVIHTVGPIARGHINGSHKED 160
            I + AG  + +E           ++   +T G++L  KY+ H +      H      + 
Sbjct: 351 SILQQAGVEMKSEFLATKAKQFQRSQLVLVTKGFNLFCKYIYHVLW-----HSEFPKPQI 405

Query: 161 LANCYKSSLKLVKENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRII 220
           L +  K  L+   E NI S++FP + TG      E AA I  + +  + AK+H +    +
Sbjct: 406 LKHAMKECLEKCIEQNITSISFPALGTGNMEIKKETAAEILFDEVLTF-AKDHVKHQLTV 464

Query: 221 FCVFLEVDFKIYK---KKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQ--------SV 269
             V    D +IYK    +M +   +   N        +E+  ENG E +         +V
Sbjct: 465 KFVIFPTDLEIYKAFSSEMAKRSKMLSLNNYSVPQSTREEKRENGLEARSPAINLMGFNV 524

Query: 270 EEMEE 274
           EEM E
Sbjct: 525 EEMYE 529


>gi|226371706 poly (ADP-ribose) polymerase family, member 9 isoform
           a [Homo sapiens]
          Length = 854

 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 50/160 (31%), Positives = 75/160 (46%), Gaps = 8/160 (5%)

Query: 55  EENTQETSQVKKSLTEKV--SLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPC 112
           E N++     +K LT ++  S+++ D+T   VDA+VNAAN  LL GGG+   + +A G  
Sbjct: 101 EGNSKSLQVFRKMLTPRIELSVWKDDLTTHAVDAVVNAANEDLLHGGGLALALVKAGGFE 160

Query: 113 LLAECRNL----NGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSS 168
           +  E +           G   +T    LP K +IH VGP             L     S 
Sbjct: 161 IQEESKQFVARYGKVSAGEIAVTGAGRLPCKQIIHAVGPRWMEWDKQGCTGKLQRAIVSI 220

Query: 169 LKLV--KENNIRSVAFPCISTGIYGFPNEPAAVIALNTIK 206
           L  V  K  +I++VA P +S+GI+ FP        + TI+
Sbjct: 221 LNYVIYKNTHIKTVAIPALSSGIFQFPLNLCTKTIVETIR 260



 Score = 55.5 bits (132), Expect = 9e-08
 Identities = 63/245 (25%), Positives = 103/245 (42%), Gaps = 23/245 (9%)

Query: 45  EEMKGKGQNDEENTQE-TSQVKKSLTEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDG 103
           E + GK +  +E T    + V  +LT  + + +G I     D IVN+ N   +  G V  
Sbjct: 293 EFILGKSELGQETTPSFNAMVVNNLT--LQIVQGHIEWQTADVIVNSVNPHDITVGPVAK 350

Query: 104 CIHRAAGPCLLAECRNLNGCDTGHAK---ITCGYDLPAKYVIHTVGPIARGHINGSHKED 160
            I + AG  + +E           ++   +T G++L  KY+ H +      H      + 
Sbjct: 351 SILQQAGVEMKSEFLATKAKQFQRSQLVLVTKGFNLFCKYIYHVLW-----HSEFPKPQI 405

Query: 161 LANCYKSSLKLVKENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRII 220
           L +  K  L+   E NI S++FP + TG      E AA I  + +  + AK+H +    +
Sbjct: 406 LKHAMKECLEKCIEQNITSISFPALGTGNMEIKKETAAEILFDEVLTF-AKDHVKHQLTV 464

Query: 221 FCVFLEVDFKIYK---KKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQ--------SV 269
             V    D +IYK    +M +   +   N        +E+  ENG E +         +V
Sbjct: 465 KFVIFPTDLEIYKAFSSEMAKRSKMLSLNNYSVPQSTREEKRENGLEARSPAINLMGFNV 524

Query: 270 EEMEE 274
           EEM E
Sbjct: 525 EEMYE 529


>gi|4758496 H2A histone family, member Y isoform 2 [Homo sapiens]
          Length = 371

 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 52/179 (29%), Positives = 85/179 (47%), Gaps = 15/179 (8%)

Query: 68  LTEKVSLYRGDITLL---EVDAIVNAANASLLGGGGVDGCIHRAAGPCLLA---ECRNLN 121
           L +K++L   +I+ L   EV+AI+N  NA +     +   + +  G   +    E R  N
Sbjct: 192 LGQKLNLIHSEISNLAGFEVEAIINPTNADIDLKDDLGNTLEKKGGKEFVEAVLELRKKN 251

Query: 122 G-CDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHK--EDLANCYKSSLKLVKENNIR 178
           G  +   A ++ G+ LPAK+VIH   P+      G+ K  E L    K+ L L  +  ++
Sbjct: 252 GPLEVAGAAVSAGHGLPAKFVIHCNSPVW-----GADKCEELLEKTVKNCLALADDKKLK 306

Query: 179 SVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKN-HHEVDRIIFCVFLEVDFKIYKKKM 236
           S+AFP I +G  GFP + AA + L  I  +        +  + F +F      IY ++M
Sbjct: 307 SIAFPSIGSGRNGFPKQTAAQLILKAISSYFVSTMSSSIKTVYFVLFDSESIGIYVQEM 365


>gi|93141020 H2A histone family, member Y isoform 2 [Homo sapiens]
          Length = 371

 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 52/179 (29%), Positives = 85/179 (47%), Gaps = 15/179 (8%)

Query: 68  LTEKVSLYRGDITLL---EVDAIVNAANASLLGGGGVDGCIHRAAGPCLLA---ECRNLN 121
           L +K++L   +I+ L   EV+AI+N  NA +     +   + +  G   +    E R  N
Sbjct: 192 LGQKLNLIHSEISNLAGFEVEAIINPTNADIDLKDDLGNTLEKKGGKEFVEAVLELRKKN 251

Query: 122 G-CDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHK--EDLANCYKSSLKLVKENNIR 178
           G  +   A ++ G+ LPAK+VIH   P+      G+ K  E L    K+ L L  +  ++
Sbjct: 252 GPLEVAGAAVSAGHGLPAKFVIHCNSPVW-----GADKCEELLEKTVKNCLALADDKKLK 306

Query: 179 SVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKN-HHEVDRIIFCVFLEVDFKIYKKKM 236
           S+AFP I +G  GFP + AA + L  I  +        +  + F +F      IY ++M
Sbjct: 307 SIAFPSIGSGRNGFPKQTAAQLILKAISSYFVSTMSSSIKTVYFVLFDSESIGIYVQEM 365


>gi|93141018 H2A histone family, member Y isoform 3 [Homo sapiens]
          Length = 372

 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 52/179 (29%), Positives = 85/179 (47%), Gaps = 15/179 (8%)

Query: 68  LTEKVSLYRGDITLL---EVDAIVNAANASLLGGGGVDGCIHRAAGPCLLA---ECRNLN 121
           L +K++L   +I+ L   EV+AI+N  NA +     +   + +  G   +    E R  N
Sbjct: 193 LGQKLNLIHSEISNLAGFEVEAIINPTNADIDLKDDLGNTLEKKGGKEFVEAVLELRKKN 252

Query: 122 G-CDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHK--EDLANCYKSSLKLVKENNIR 178
           G  +   A ++ G+ LPAK+VIH   P+      G+ K  E L    K+ L L  +  ++
Sbjct: 253 GPLEVAGAAVSAGHGLPAKFVIHCNSPVW-----GADKCEELLEKTVKNCLALADDKKLK 307

Query: 179 SVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKN-HHEVDRIIFCVFLEVDFKIYKKKM 236
           S+AFP I +G  GFP + AA + L  I  +        +  + F +F      IY ++M
Sbjct: 308 SIAFPSIGSGRNGFPKQTAAQLILKAISSYFVSTMSSSIKTVYFVLFDSESIGIYVQEM 366


>gi|165377137 poly (ADP-ribose) polymerase family, member 15 isoform
           1 [Homo sapiens]
          Length = 678

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 55/180 (30%), Positives = 78/180 (43%), Gaps = 12/180 (6%)

Query: 57  NTQETSQVKKSLTEKVSLYRGDITLLEVDAIVNAANASL-LGGGGVDGCIHRAAGPCLLA 115
           N   + Q K+ L  K  L  GD+  +  D IVN+   +L LGGG +     + AGP L  
Sbjct: 78  NVVASIQTKEGLNLK--LISGDVLYIWADVIVNSVPMNLQLGGGPLSRAFLQKAGPMLQK 135

Query: 116 EC---RNLNGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLV 172
           E    R       G+  +T G +L  K V+H V P        S  + +AN  K  L  V
Sbjct: 136 ELDDRRRETEEKVGNIFMTSGCNLDCKAVLHAVAPYWNNGAETSW-QIMANIIKKCLTTV 194

Query: 173 KENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIY 232
           +  +  S+ FP I TG   FP    A + L+ + E+ +       R I     EV F +Y
Sbjct: 195 EVLSFSSITFPMIGTGSLQFPKAVFAKLILSEVFEYSSST-----RPITSPLQEVHFLVY 249



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 34/115 (29%), Positives = 46/115 (40%), Gaps = 11/115 (9%)

Query: 77  GDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCDTGHAKITCGYDL 136
           GDI   +VD IVN+   +     GV   I   AG  + +EC  L         IT G  L
Sbjct: 311 GDIATEQVDVIVNSTARTFNRKSGVSRAILEGAGQAVESECAVLAAQPHRDFIITPGGCL 370

Query: 137 PAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSVAFPCISTGIYG 191
             K +IH  G            +D+     S L+  ++    SV+ P I TG  G
Sbjct: 371 KCKIIIHVPG-----------GKDVRKTVTSVLEECEQRKYTSVSLPAIGTGNAG 414


>gi|24415404 MDN1, midasin homolog [Homo sapiens]
          Length = 5596

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 49/208 (23%), Positives = 88/208 (42%), Gaps = 17/208 (8%)

Query: 226  EVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEM------EEQSQDA 279
            + D K++  ++ E    D+ ++ E     K   D NG E  +  E +      EE  ++ 
Sbjct: 4732 DFDGKMHDGELEEQEEDDEKSDSEGGDLDKHMGDLNGEEADKLDERLWGDDDEEEDEEEE 4791

Query: 280  DGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRD--QDHPDGQENDSTKN 337
            D     T PG   E++      E  AKD+N+  G    D S +D  ++  + + +D  + 
Sbjct: 4792 DNKTEETGPGMDEEDS------ELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADDGGQG 4845

Query: 338  EIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKS 397
            E KI  +      +  E+     +   V +PE + L +D      +K  GEDT    G+ 
Sbjct: 4846 EDKINEQIDERDYDENEVDPYHGNQEKVPEPEALDLPDDLNLDSEDKNGGEDTDNEEGEE 4905

Query: 398  EGSSDLENTP---GPDAGAQDEAKEQRN 422
            E   +++  P   G +A  + E +  +N
Sbjct: 4906 ENPLEIKEKPEEAGHEAEERGETETDQN 4933



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 43/175 (24%), Positives = 68/175 (38%), Gaps = 16/175 (9%)

Query: 250  EDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDEN 309
            ED + +E  +EN  E K+  EE   ++++     T      + +E  E   ++D A    
Sbjct: 4896 EDTDNEEGEEENPLEIKEKPEEAGHEAEERGETETDQNESQSPQEPEEGPSEDDKA---- 4951

Query: 310  ITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPE 369
              +G E  D    DQD    Q  +    E +   E +    + E   +   D     Q E
Sbjct: 4952 --EGEEEMDTGADDQDGDAAQHPEEHSEEQQQSVEEKDKEADEEGGENGPADQGFQPQEE 5009

Query: 370  VIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPD----AGAQDEAKEQ 420
                 E++E+ + E+   E   R    S G + +EN         AGA  E KEQ
Sbjct: 5010 -----EEREDSDTEEQVPEALERKEHASCGQTGVENMQNTQAMELAGAAPE-KEQ 5058



 Score = 35.8 bits (81), Expect = 0.076
 Identities = 38/177 (21%), Positives = 69/177 (38%), Gaps = 36/177 (20%)

Query: 243  DDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDE 302
            DD N + ED    ED+D    EE+  +E  E+             P  A  EA E  + E
Sbjct: 4883 DDLNLDSEDKNGGEDTDNEEGEEENPLEIKEK-------------PEEAGHEAEERGETE 4929

Query: 303  DFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDA 362
                D+N ++  +  +    + D  +G+E   T      + +   +    EE S  Q+ +
Sbjct: 4930 T---DQNESQSPQEPEEGPSEDDKAEGEEEMDT----GADDQDGDAAQHPEEHSEEQQQS 4982

Query: 363  VIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDEAKE 419
            V            ++++KE ++  GE+ P      +G    E     D+  +++  E
Sbjct: 4983 V------------EEKDKEADEEGGENGP----ADQGFQPQEEEEREDSDTEEQVPE 5023


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 48/199 (24%), Positives = 84/199 (42%), Gaps = 9/199 (4%)

Query: 225  LEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNT 284
            LEV+ +  + +       +D    E + EM+E  +E  PE      + + + ++A  V  
Sbjct: 1980 LEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEG 2039

Query: 285  VTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETE 344
             T       +   D  +   A++E     GEV +     + HP+ ++ D+ + E + + E
Sbjct: 2040 ETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQE--AEGEAHPESEDVDAQEAEGEAQPE 2097

Query: 345  SQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAP---GEDTPRMPGKSEGSS 401
            S+   +E  E     + A  +E PE     E Q E EG +AP   GE  P   G     +
Sbjct: 2098 SEG--VEAPEAEGEAQKAEGIEAPET--EGEAQPESEGIEAPEAEGEAQPESEGVEAQDA 2153

Query: 402  DLENTPGPDAGAQDEAKEQ 420
            + E  P  +     EA+E+
Sbjct: 2154 EGEAQPESEGIEAQEAEEE 2172



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 41/182 (22%), Positives = 79/182 (43%), Gaps = 14/182 (7%)

Query: 238  EFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQ-DADGVNTVTVPGPASEEAV 296
            E   V+   +E E     E  D   PE +  ++E EE++Q ++DGV           EA 
Sbjct: 1978 EALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGV-----------EAQ 2026

Query: 297  EDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELS 356
               + E+  + E  T+  E       D       E ++ + E +++     ++ E+E++ 
Sbjct: 2027 PKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVD 2086

Query: 357  SNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDE 416
            + + +     QPE   +   + E E +KA G + P   G+++  S+    P  +  AQ E
Sbjct: 2087 AQEAEGEA--QPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPE 2144

Query: 417  AK 418
            ++
Sbjct: 2145 SE 2146



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 45/188 (23%), Positives = 78/188 (41%), Gaps = 12/188 (6%)

Query: 247  EEEEDVEMKEDSDENGPEEK--QSVEEMEEQSQDADGVNTVTVPGPASEEA--VEDCKDE 302
            ++ E +E  E   E  PE +  ++ E   E   +++GV      G A  E+  +E  + E
Sbjct: 2111 QKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAE 2170

Query: 303  DFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDA 362
            + A+ E   +G E  +     Q   +G E    + E + E E   +  E EE +  + + 
Sbjct: 2171 EEAQPE--LEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEA-PEAEEEAQPEPEG 2227

Query: 363  VIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDL-----ENTPGPDAGAQDEA 417
            V   + E     E + E +GEK          G+SE +S+      E+ P P      + 
Sbjct: 2228 VETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDT 2287

Query: 418  KEQRNGTK 425
              QR G++
Sbjct: 2288 PHQRPGSQ 2295



 Score = 38.1 bits (87), Expect = 0.015
 Identities = 35/151 (23%), Positives = 66/151 (43%), Gaps = 10/151 (6%)

Query: 275  QSQDADGVNTVTVPG---PASE--EAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDG 329
            QS  A+G+      G   P SE  EA E   D   A+ E   +  +V       +  P+ 
Sbjct: 1828 QSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPES 1887

Query: 330  QENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGED 389
            ++ ++ + E +++ ES+ +     E  +  E     E  E +  TE ++E E E A  ++
Sbjct: 1888 EDVETPEAEWEVQPESEGAEAPEAEKEAQPE----TESVEALE-TEGEDEPESEGAEAQE 1942

Query: 390  TPRMPGKSEGSSDLENTPGPDAGAQDEAKEQ 420
                  ++EG +  E+       A++EA+ +
Sbjct: 1943 AEEAAQEAEGQTQPESEVIESQEAEEEAQPE 1973



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 45/186 (24%), Positives = 71/186 (38%), Gaps = 36/186 (19%)

Query: 248  EEEDVEMKEDSDENG---PEEKQSVEEMEE---QSQDADGVNTVTV-PGPASEEAVEDCK 300
            +EE V+++E  +  G    EE+  +EE+EE   +    +GV    V  GP  E  ++   
Sbjct: 1332 QEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGP--EGGLQGEA 1389

Query: 301  DEDFAKDENITKGGEVTDHSVRDQDHPDG---QENDSTKNEIKIETESQSSYMETEELSS 357
             E+  K+E + + G V    + +   PDG   QE+D  + E            E    S+
Sbjct: 1390 LEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEE------------EAGRASA 1437

Query: 358  NQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSS---DLENTPGPDAGAQ 414
            + E           P    +E  E      E  P    +  GS     LE  PG     Q
Sbjct: 1438 SAEPC---------PAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQ 1488

Query: 415  DEAKEQ 420
            +  + Q
Sbjct: 1489 EHTQAQ 1494



 Score = 31.6 bits (70), Expect = 1.4
 Identities = 37/173 (21%), Positives = 69/173 (39%), Gaps = 12/173 (6%)

Query: 251  DVEMKEDSDENGPEEKQSVEEMEEQSQDA--DGVNTVTVPGPASEEAVEDCKDEDFAKDE 308
            ++ +K  +        +S  ++E Q Q      +N        +E+  E   +E  A   
Sbjct: 1229 ELPLKTSNQRPDSRTYESPGDLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSN 1288

Query: 309  NITKGGEVTDHSVRDQDHPDGQENDSTKNE-IKIETESQSSYMETEELSSNQEDAVIVEQ 367
                        V+ ++  +G E +  + E +++E        ET+     QE+ V +E+
Sbjct: 1289 LEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLE--------ETKTEEGLQEEGVQLEE 1340

Query: 368  PEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDEAKEQ 420
             +     E Q+E+E +    E+T     + EG    E   GP+ G Q EA E+
Sbjct: 1341 TKETE-GEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEE 1392


>gi|210032580 SET domain containing 1B [Homo sapiens]
          Length = 1923

 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 44/175 (25%), Positives = 69/175 (39%), Gaps = 21/175 (12%)

Query: 242  VDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKD 301
            +D   EE+E   + E+ +    EE+   EE EE   D D                 D +D
Sbjct: 1029 LDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDD----------------SDDRD 1072

Query: 302  EDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQED 361
            E    DE+      +++ S +D+   D +E  S        T S  S   +E  SS++  
Sbjct: 1073 ESENDDEDTA----LSEASEKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESS 1128

Query: 362  AVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTP-GPDAGAQD 415
                E  E +   E++EE+E E+   E++    G  +   D E     P A A D
Sbjct: 1129 PSSSEDEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVD 1183



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 36/165 (21%), Positives = 69/165 (41%), Gaps = 15/165 (9%)

Query: 225  LEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNT 284
            LE+D    + +        ++ EEEE+ E +E+ +++  ++    +E E   +D      
Sbjct: 1027 LELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDED------ 1080

Query: 285  VTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETE 344
             T    ASE+   D  +E+      +T   E T  S    +  +  E +S+       +E
Sbjct: 1081 -TALSEASEKDEGDSDEEETV--SIVTSKAEATSSS----ESSESSEFESSSESSPSSSE 1133

Query: 345  SQSSYMETEELSSNQEDAVIVEQPEVIPLTED--QEEKEGEKAPG 387
             +   +  EE    +E+ ++ E+       ED  Q+ +E   APG
Sbjct: 1134 DEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPG 1178



 Score = 35.4 bits (80), Expect = 0.099
 Identities = 34/191 (17%), Positives = 71/191 (37%), Gaps = 27/191 (14%)

Query: 229  FKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEM--EEQSQDADGVNTVT 286
            FK+ +K+  +  S  D         + E+ +E+  E  + + +   E   +D  GV    
Sbjct: 962  FKVKRKEPPDTTSSGDQKRLRPSTSVDEEDEESERERDRDMADTPCELAKRDPKGVGVRR 1021

Query: 287  VPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQ 346
             P                A+   +  GGE  +     ++    +E +  + E + E +  
Sbjct: 1022 RP----------------ARPLELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDD 1065

Query: 347  SSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENT 406
                + +E  ++ ED           L+E  E+ EG+    E    +  K+E +S  E++
Sbjct: 1066 DDSDDRDESENDDEDTA---------LSEASEKDEGDSDEEETVSIVTSKAEATSSSESS 1116

Query: 407  PGPDAGAQDEA 417
               +  +  E+
Sbjct: 1117 ESSEFESSSES 1127



 Score = 33.1 bits (74), Expect = 0.49
 Identities = 29/159 (18%), Positives = 69/159 (43%), Gaps = 14/159 (8%)

Query: 243  DDNNEEEEDVEMKEDS--DENGPEEKQSVEEM--------EEQSQDADGVNTVTVPGPAS 292
            D++  ++ED  + E S  DE   +E+++V  +          +S ++    + +   P+S
Sbjct: 1072 DESENDDEDTALSEASEKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSS 1131

Query: 293  EEAVED--CKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYM 350
             E  E+   ++E+  ++E      E    +  +    DG+E         +++      +
Sbjct: 1132 SEDEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEV 1191

Query: 351  --ETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPG 387
              ETE ++  +  +++ E P  + + E  + +E  + PG
Sbjct: 1192 DIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPG 1230



 Score = 29.6 bits (65), Expect = 5.4
 Identities = 32/152 (21%), Positives = 61/152 (40%), Gaps = 18/152 (11%)

Query: 241  SVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEE---QSQDADGVNTVTVPGPASEEAVE 297
            S   ++E+EE+V  +E+ +E   EE  + E M     +  + DG      PG  + +++ 
Sbjct: 1127 SSPSSSEDEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSL- 1185

Query: 298  DCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSS 357
                     +E +    ++   +V  ++ P     D     + +E E   S    EE   
Sbjct: 1186 -------GMEEEV----DIETEAVAPEERP--SMLDEPPLPVGVE-EPADSREPPEEPGL 1231

Query: 358  NQEDAVIVEQPEVIPLTEDQEEKEGEKAPGED 389
            +QE A+++         E +     E+AP  D
Sbjct: 1232 SQEGAMLLSPEPPAKEVEARPPLSPERAPEHD 1263



 Score = 29.3 bits (64), Expect = 7.1
 Identities = 21/84 (25%), Positives = 33/84 (39%), Gaps = 11/84 (13%)

Query: 341  IETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGS 400
            +E +S     E E LS  QE              E++E +E E+   +D      + E  
Sbjct: 1027 LELDSGGEEDEKESLSEEQEST-----------EEEEEAEEEEEEEDDDDDDSDDRDESE 1075

Query: 401  SDLENTPGPDAGAQDEAKEQRNGT 424
            +D E+T   +A  +DE       T
Sbjct: 1076 NDDEDTALSEASEKDEGDSDEEET 1099


>gi|13540523 nucleosomal binding protein 1 [Homo sapiens]
          Length = 282

 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 44/183 (24%), Positives = 83/183 (45%), Gaps = 10/183 (5%)

Query: 248 EEEDVEMKE----DSDENGPEEKQSVE---EMEEQSQDADGVNTVTVPGPASEEAVEDCK 300
           E+E VE+KE    D+ E G E+K++V    + EE+ Q  D  +     G A +E  ++  
Sbjct: 94  EKEIVEVKEENIEDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKG 153

Query: 301 DEDFAKDENITKGGEVTDHSVRDQDHPDGQ---ENDSTKNEIKIETESQSSYMETEELSS 357
           +ED  +D+N  + GE        +   DG+   E+   K E + E E +    + +E   
Sbjct: 154 EEDGKEDKNGNEKGEDAKEKEDGKKGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENED 213

Query: 358 NQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDEA 417
            +E     E  +V    +++E ++G++  G +      + E   + E     D   +D+ 
Sbjct: 214 GKEKGDKKEGKDVKVKEDEKEREDGKEDEGGNEEEAGKEKEDLKEEEEGKEEDEIKEDDG 273

Query: 418 KEQ 420
           K++
Sbjct: 274 KKE 276



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 46/181 (25%), Positives = 76/181 (41%), Gaps = 16/181 (8%)

Query: 243 DDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDE 302
           +D NE  ++ E K    E    EK+ VE  EE  +DA           A+E   E+   +
Sbjct: 74  EDYNENAKNGEAK--ITEAPASEKEIVEVKEENIEDATEKGGEKKEAVAAEVKNEEEDQK 131

Query: 303 DFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDA 362
           +  +D+N  KG E       ++   DG+E D   NE   + + +    + E+   N ED 
Sbjct: 132 EDEEDQNEEKG-EAGKEDKDEKGEEDGKE-DKNGNEKGEDAKEKEDGKKGEDGKGNGEDG 189

Query: 363 VIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDEAKEQRN 422
                       ED++E+E  K  G+      GK +G    +   G D   +++ KE+ +
Sbjct: 190 K--------EKGEDEKEEEDRKETGDGKENEDGKEKG----DKKEGKDVKVKEDEKERED 237

Query: 423 G 423
           G
Sbjct: 238 G 238



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 45/175 (25%), Positives = 77/175 (44%), Gaps = 17/175 (9%)

Query: 254 MKEDSDENGP---EEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENI 310
           M+E+ D +     E KQ     E+ +++A          PASE+ + + K+E+   ++  
Sbjct: 52  MEENIDTSAQAVAETKQEAVVEEDYNENAKNGEAKITEAPASEKEIVEVKEENI--EDAT 109

Query: 311 TKGGEVTDHSVRD--QDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQP 368
            KGGE  +    +   +  D +E++  +NE K E   +    + EE    +ED    E+ 
Sbjct: 110 EKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEE--DGKEDKNGNEKG 167

Query: 369 EVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDEAKEQRNG 423
           E     ED ++ E  K  GED     GK +G  + E     + G   + KE  +G
Sbjct: 168 EDAKEKEDGKKGEDGKGNGED-----GKEKGEDEKEEEDRKETG---DGKENEDG 214



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 40/153 (26%), Positives = 69/153 (45%), Gaps = 21/153 (13%)

Query: 243 DDNNEEEEDVEMKEDSDE----NGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVED 298
           +D NEE+ +   KED DE    +G E+K   E+ E+  +  DG       G   E+  E 
Sbjct: 135 EDQNEEKGEAG-KEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKG-NGEDGKEK 192

Query: 299 CKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTK--NEIKIETESQSSYMETEELS 356
            +DE   +D   T  G         +++ DG+E    K   ++K++ + +      E+  
Sbjct: 193 GEDEKEEEDRKETGDG---------KENEDGKEKGDKKEGKDVKVKEDEKEREDGKEDEG 243

Query: 357 SNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGED 389
            N+E+A      E   L E++E KE ++   +D
Sbjct: 244 GNEEEA----GKEKEDLKEEEEGKEEDEIKEDD 272



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 29/119 (24%), Positives = 51/119 (42%), Gaps = 15/119 (12%)

Query: 244 DNNEEEEDVEMKED---------SDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEE 294
           + NE+ ED + KED         + E+G E+ +  +E E++ +  DG           ++
Sbjct: 162 NGNEKGEDAKEKEDGKKGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKGDKK 221

Query: 295 AVEDCK---DEDFAKDENITKGGEVTDHSVRDQD---HPDGQENDSTKNEIKIETESQS 347
             +D K   DE   +D    +GG   +     +D     +G+E D  K +   + E QS
Sbjct: 222 EGKDVKVKEDEKEREDGKEDEGGNEEEAGKEKEDLKEEEEGKEEDEIKEDDGKKEEPQS 280


>gi|46409304 glutamate-rich 1 [Homo sapiens]
          Length = 443

 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 39/137 (28%), Positives = 61/137 (44%), Gaps = 14/137 (10%)

Query: 242 VDDNNEE-----EEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAV 296
           VD + E+     EEDV+   + D     E+      +E+  DA   +    P PA EE V
Sbjct: 211 VDTSEEDPTLAGEEDVKDTREEDGADASEEDLTRARQEEGADASEED----PTPAGEEDV 266

Query: 297 EDCKDEDFAK--DENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEE 354
           +D ++ED     +E++T+ GE      R++D  D  E D T      E E   S  E   
Sbjct: 267 KDAREEDGVDTIEEDLTRAGEEDGKDTREEDGADASEEDPTWAG---EEEGADSGEEDGA 323

Query: 355 LSSNQEDAVIVEQPEVI 371
            +S ++D +  E+   I
Sbjct: 324 DASEEDDTITNEKAHSI 340


>gi|21735569 claspin [Homo sapiens]
          Length = 1339

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 38/141 (26%), Positives = 67/141 (47%), Gaps = 14/141 (9%)

Query: 233 KKKMNEFFSVDDNN----EEEEDVEMKEDSDENGPE-------EKQSVEEMEEQSQDADG 281
           ++K    F +D+ +    EEEE+ EM ++S+E+G E       E++  EE E++ ++ + 
Sbjct: 613 RQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEE 672

Query: 282 VNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKI 341
            N  T     S E +E   +++  K+ N   G      +V     P    +DST    K 
Sbjct: 673 GNQETAEFLLSSEEIETKDEKEMDKENN--DGSSEIGKAVGFLSVPKSLSSDSTLLLFK- 729

Query: 342 ETESQSSYMETEELSSNQEDA 362
           ++ S+  Y  TEE S   E++
Sbjct: 730 DSSSKMGYFPTEEKSETDENS 750



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 32/168 (19%), Positives = 71/168 (42%), Gaps = 9/168 (5%)

Query: 230 KIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPG 289
           ++ K K+ E   +    E ++   + +  +E+G EE++  EE      + DG   V    
Sbjct: 595 QVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKV---- 650

Query: 290 PASEEAVEDCKDEDFAKDENITKGGEVTDH---SVRDQDHPDGQENDSTKNEIKIETESQ 346
              EE  E+ ++E+  ++E   +G + T     S  + +  D +E D   N+   E    
Sbjct: 651 -EKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENNDGSSEIGKA 709

Query: 347 SSYMET-EELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRM 393
             ++   + LSS+    +  +    +     +E+ E ++  G+   ++
Sbjct: 710 VGFLSVPKSLSSDSTLLLFKDSSSKMGYFPTEEKSETDENSGKQPSKL 757


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 41/181 (22%), Positives = 74/181 (40%), Gaps = 6/181 (3%)

Query: 226 EVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTV 285
           E   K+ +K   E   V++  EE +  E   + +E   +E++  EE   + ++A+G    
Sbjct: 441 EEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEE 500

Query: 286 TVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETES 345
           T   PA E A  + + +   K+E  +     +      +   + +  +  K+  K E +S
Sbjct: 501 TKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKS 560

Query: 346 --QSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDL 403
             ++   E EE  S  E    V+ PE       +E K   +A   +  + P K E  S  
Sbjct: 561 PPEAKSPEKEEAKSPAE----VKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPA 616

Query: 404 E 404
           E
Sbjct: 617 E 617



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 40/163 (24%), Positives = 73/163 (44%), Gaps = 10/163 (6%)

Query: 230  KIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPG 289
            K  +KK ++          +  VE K++     P+E + VE  +E+++D   V T     
Sbjct: 852  KTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESK-VEAKKEEAEDKKKVPTPEKEA 910

Query: 290  PASEEAVEDCKDED----FAKDENITKGGEVTDHSVRDQDHP---DGQENDSTKNEIKIE 342
            PA  E  ED K ++      K+ +  K  E +  + + +  P   D +E  + K E K +
Sbjct: 911  PAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPK 970

Query: 343  TESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKA 385
            TE+++   E ++  S +      E+ E    T+ ++ K  EKA
Sbjct: 971  TEAKAK--EDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKA 1011



 Score = 34.3 bits (77), Expect = 0.22
 Identities = 43/179 (24%), Positives = 67/179 (37%), Gaps = 13/179 (7%)

Query: 249 EEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEE---AVEDCKDEDFA 305
           +ED +  E       E K  V+E EE+ Q+   V     P  A EE   A    +++  +
Sbjct: 804 KEDAKAPEKEIPKKEEVKSPVKE-EEKPQE---VKVKEPPKKAEEEKAPATPKTEEKKDS 859

Query: 306 KDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSN-----QE 360
           K E   K  E     V ++  P  ++   +K E K E       + T E  +      +E
Sbjct: 860 KKEEAPKK-EAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKE 918

Query: 361 DAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDEAKE 419
           DA   E+ EV     D  + +    P E     P K +   +    P      + +AKE
Sbjct: 919 DAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKE 977



 Score = 33.9 bits (76), Expect = 0.29
 Identities = 37/193 (19%), Positives = 72/193 (37%), Gaps = 27/193 (13%)

Query: 233 KKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQS---------------- 276
           +K+  E    ++   EEE+ E  E+  ++ P E+ +  E E +S                
Sbjct: 475 EKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPE 534

Query: 277 -QDADGVNTVTVPGPASEEAVEDCK--------DEDFAKDENITKGGEVTDHSVRDQDHP 327
            ++A     V  P  A   A E+ K        +++ AK     K  E      +++   
Sbjct: 535 KEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKS 594

Query: 328 DGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKA-- 385
             +     K +  ++ E++S       +    +    V+ PE       +E K  EKA  
Sbjct: 595 PAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKS 654

Query: 386 PGEDTPRMPGKSE 398
           P ++  + P K++
Sbjct: 655 PEKEEAKSPEKAK 667



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 38/183 (20%), Positives = 70/183 (38%), Gaps = 15/183 (8%)

Query: 253 EMKEDSDENGPEEKQSVEEMEEQS---------QDADGVNTVTVPGPASEEAVEDCKDED 303
           E K  ++   PE+ +S  + E +S         ++A     V  P  A     E+ K  +
Sbjct: 591 EAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPE 650

Query: 304 FAK--DENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQED 361
            AK  ++   K  E     V+ +     +     K E K   +++S   E  +     + 
Sbjct: 651 KAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKS 710

Query: 362 AVIVE--QPEVI--PLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDEA 417
            V  E   PE    P+ E+ +  E  K+P ++  + P K++     +        A+  A
Sbjct: 711 PVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPA 770

Query: 418 KEQ 420
           KE+
Sbjct: 771 KEE 773



 Score = 30.8 bits (68), Expect = 2.4
 Identities = 40/195 (20%), Positives = 72/195 (36%), Gaps = 46/195 (23%)

Query: 247 EEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAK 306
           E+ +  E  +  D   PE K   +E      D         P  A     E+ K  + AK
Sbjct: 748 EKAKSPEKAKTLDVKSPEAKTPAKEEARSPADK-------FPEKAKSPVKEEVKSPEKAK 800

Query: 307 DENITKGGEVTDHSVRDQDHPDGQENDSTKNEIK--IETESQSSYMETEELSSNQEDAVI 364
                        S   +D    ++    K E+K  ++ E +   ++ +E     E+   
Sbjct: 801 -------------SPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEE--- 844

Query: 365 VEQPEVIPLTEDQEEKEGEKAPGEDTP------------------RMPGKSEGSSDLENT 406
            E+    P TE++++ + E+AP ++ P                  ++  K E + D +  
Sbjct: 845 -EKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKV 903

Query: 407 PGP--DAGAQDEAKE 419
           P P  +A A+ E KE
Sbjct: 904 PTPEKEAPAKVEVKE 918



 Score = 28.9 bits (63), Expect = 9.3
 Identities = 37/152 (24%), Positives = 55/152 (36%), Gaps = 23/152 (15%)

Query: 250 EDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDEN 309
           E  +     +   P E +S E+ EE    A+  +      PA EEA          K   
Sbjct: 548 EKAKSPAKEEAKSPPEAKSPEK-EEAKSPAEVKSPEKAKSPAKEEA----------KSPA 596

Query: 310 ITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPE 369
             K  E     V+++     +     K E K   E +S     +  S  +E+A   + PE
Sbjct: 597 EAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKS---PEKAKSPTKEEA---KSPE 650

Query: 370 VIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSS 401
                E +E K  EKA      + P K+E  S
Sbjct: 651 KAKSPEKEEAKSPEKA------KSPVKAEAKS 676


>gi|4504487 histidine rich calcium binding protein precursor [Homo
           sapiens]
          Length = 699

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 54/203 (26%), Positives = 81/203 (39%), Gaps = 36/203 (17%)

Query: 249 EEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPA--------------SEE 294
           EED E+  +     P  +QS ++ E        +  ++   P               SEE
Sbjct: 425 EEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEE 484

Query: 295 AVEDCKDEDFAK----DENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYM 350
             E  K+ED       DE+  +G + T H  RDQ+  + +E     +  + E E +    
Sbjct: 485 EKE--KEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEE 542

Query: 351 ETEELSSNQEDAVIVEQPEV-IPLTEDQEEKEGEKAPG--EDTPRMP--------GKSEG 399
           E EE    + +    E+ EV  PL+ D  E+E E+  G  ED PR           +  G
Sbjct: 543 EEEEEDEERRE----ERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAG 598

Query: 400 SSDLENTPGPDAGAQDEAKEQRN 422
            +  E   G D G QD A+E  N
Sbjct: 599 GASSEEESGEDTGPQD-AQEYGN 620



 Score = 35.8 bits (81), Expect = 0.076
 Identities = 44/170 (25%), Positives = 70/170 (41%), Gaps = 14/170 (8%)

Query: 243 DDNNEEEEDVEMKED--SDENGPEEKQSVEEMEEQSQD-ADGVNTVTVPGPA----SEEA 295
           DD  EEEE+ E +E+  S E G +  +      E+ +D +DG +     GP+      E 
Sbjct: 189 DDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHH---HGPSHRHQGHEE 245

Query: 296 VEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEEL 355
            +D  D+D   D++     E    + R Q H  G E D   ++     +    +   EE 
Sbjct: 246 DDDDDDDDDDDDDDDDVSIEYRHQAHRHQGH--GIEEDEDVSDGHHHRDPSHRHRSHEE- 302

Query: 356 SSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPG-KSEGSSDLE 404
             N +D V  E        +D  ++E E   GE    +P  + +G  D E
Sbjct: 303 DDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEE 352



 Score = 35.8 bits (81), Expect = 0.076
 Identities = 20/101 (19%), Positives = 49/101 (48%), Gaps = 7/101 (6%)

Query: 243 DDNNEEEEDVEMKEDSDENGPEEKQSV------EEMEEQSQDADGVNTVTVPGPASEEAV 296
           ++  E+EED    E+ DE+  + ++        +E EE  ++  G++         ++  
Sbjct: 483 EEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEE 542

Query: 297 EDCKDEDFAKDENITKGGEVT-DHSVRDQDHPDGQENDSTK 336
           E+ ++++  ++E    G  ++ DHS  +++  +G E D  +
Sbjct: 543 EEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPR 583



 Score = 31.6 bits (70), Expect = 1.4
 Identities = 25/81 (30%), Positives = 36/81 (44%), Gaps = 14/81 (17%)

Query: 241 SVDDNNEEEEDVEMKEDS-DENGPEEKQSV-----------EEMEEQSQDADGVNTVTVP 288
           S++   EEEED E +E+  DE   EE+  V           EE EE+  + D      +P
Sbjct: 529 SLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIP 588

Query: 289 GPAS--EEAVEDCKDEDFAKD 307
            P    EEA     +E+  +D
Sbjct: 589 NPLDRREEAGGASSEEESGED 609



 Score = 30.0 bits (66), Expect = 4.2
 Identities = 29/145 (20%), Positives = 58/145 (40%), Gaps = 6/145 (4%)

Query: 249 EEDVEMKEDSDENGPEEK-QSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKD 307
           EED ++ +    +GP  + Q  EE ++   D D  +                +     +D
Sbjct: 222 EEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEED 281

Query: 308 ENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQ 367
           E+++ G    D S R + H   +E+D+  +++  E   Q+     ++    + +AV  E 
Sbjct: 282 EDVSDGHHHRDPSHRHRSH---EEDDNDDDDVSTEYGHQAH--RHQDHRKEEVEAVSGEH 336

Query: 368 PEVIPLTEDQEEKEGEKAPGEDTPR 392
              +P    Q  ++ E+     T R
Sbjct: 337 HHHVPDHRHQGHRDEEEDEDVSTER 361



 Score = 29.6 bits (65), Expect = 5.4
 Identities = 19/72 (26%), Positives = 36/72 (50%), Gaps = 7/72 (9%)

Query: 241 SVDDNNEEEED----VEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAV 296
           S D  +EE+E+    + + ++ +E   +E++  EE EE+ ++   V     P  + EE  
Sbjct: 513 SRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEE 572

Query: 297 EDCKDEDFAKDE 308
           E   +E   +DE
Sbjct: 573 E---EEGLEEDE 581


>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
            sapiens]
          Length = 1130

 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 53/225 (23%), Positives = 95/225 (42%), Gaps = 36/225 (16%)

Query: 225  LEVDFKIYKKKMNEFFSVDDNNEEEEDV----------EMKEDSDENGPEEKQSVEEMEE 274
            LE D  +     ++    ++  EEEE+           E +ED +E   EE++  EE EE
Sbjct: 874  LEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEE 933

Query: 275  QSQDADG--VNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQEN 332
            + ++ +G             EE +E+ +D +F      T GGEV + +      P     
Sbjct: 934  EFEEEEGELEEEEEEEDEEEEEELEEVEDLEFG-----TAGGEVEEGAPPPPTLPPALPP 988

Query: 333  DSTKNEIKIETESQSS-YMETEELSSNQE---DAVIVEQPEVIPLTEDQEEKEGEKAPG- 387
              +  +++ E E +    +E EE  + +E   D      PE +P ++ + E+EGE     
Sbjct: 989  PESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALP-SQGEVEREGESPAAG 1047

Query: 388  -------EDTPRMP-----GKSEGSSDLENTPGPDAGAQDEAKEQ 420
                   E+ P  P      ++E  SD +  P P+  A++E + +
Sbjct: 1048 PPPQELVEEEPSAPPTLLEEETEDGSD-KVQPPPETPAEEEMETE 1091


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
           sapiens]
          Length = 1152

 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 45/197 (22%), Positives = 79/197 (40%), Gaps = 19/197 (9%)

Query: 243 DDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDE 302
           D   EEE++ E KE+ +    E ++  EE E + ++  G       G    +  E  ++E
Sbjct: 744 DREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEE---KGEEEGDQGEGEEEE 800

Query: 303 DFAKDENITKGGEVTDHSVRD---------------QDHPDGQENDSTKNEIKIETESQS 347
              + E   +GGEV    V +               ++  +G+E +    E + E + + 
Sbjct: 801 TEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEE 860

Query: 348 SYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTP 407
              E E     +E     E+ E     E++ E EGE+  GE      G+ EG  +     
Sbjct: 861 EGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGK 920

Query: 408 GPDAGAQDEAK-EQRNG 423
           G + G + E + E+  G
Sbjct: 921 GEEEGEEGEGEGEEEEG 937



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 44/179 (24%), Positives = 74/179 (41%), Gaps = 19/179 (10%)

Query: 243 DDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDE 302
           ++   EEE+ E +E+  E   EE+    E EE+ ++ +G           EE  E   +E
Sbjct: 838 EEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEE 897

Query: 303 DFAKDENITKG-GEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQED 361
           +  + E   +G GE  +     +   +G+E +    E + E E +    E EE     E 
Sbjct: 898 EEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEG 957

Query: 362 AVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDEAKEQ 420
                         ++EE EGE   GE+     G+ EG  + E   G   G ++E +E+
Sbjct: 958 --------------EEEEGEGE---GEEEGEGEGE-EGEGEGEEEEGEGEGEEEEGEEE 998



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 49/199 (24%), Positives = 88/199 (44%), Gaps = 22/199 (11%)

Query: 232 YKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPA 291
           ++K+ N+   +++  EEE     +E+ D    EEK+   + E + ++        V G  
Sbjct: 719 HQKERNQ--EMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEE--------VEGER 768

Query: 292 SEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQ-ENDSTKNEI---KIETESQS 347
            +E  E  K+E   K+E   KG E  D    +++  +G+ E      E+   ++E E + 
Sbjct: 769 EKEEGERKKEERAGKEE---KGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVE-EGKG 824

Query: 348 SYMETEELSSNQEDAVIVEQPEVIPLTEDQE---EKEGEKAPGEDTPRMPGKSEGSSDLE 404
              E EE    +E+    E+ E     E+ E   E+EGE+  GE+     G+ EG  +  
Sbjct: 825 EREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGE-EGEGEGEEEEG 883

Query: 405 NTPGPDAGAQDEAKEQRNG 423
              G + G  +  +E+  G
Sbjct: 884 EGEGEEEGEGEGEEEEGEG 902



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 47/190 (24%), Positives = 76/190 (40%), Gaps = 18/190 (9%)

Query: 243 DDNNEEEEDVEMK-EDSDENGPEEKQSVEE----MEEQSQDADGVNTV----TVPGPASE 293
           D    EEE+ E + E+ +E G  E   VEE     EE+ ++ +G           G   E
Sbjct: 792 DQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEE 851

Query: 294 EAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETE 353
           E  E   +E+  + E   +G E       ++   +G+E    + E   E E +    E  
Sbjct: 852 EEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGE---EEEGEGEGEEEG 908

Query: 354 ELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDAGA 413
           E    +E+     + E      + EE+EGE   GED     G+ EG  +     G +   
Sbjct: 909 EGEGEEEEGEGKGEEEGEEGEGEGEEEEGE-GEGED-----GEGEGEEEEGEWEGEEEEG 962

Query: 414 QDEAKEQRNG 423
           + E +E+  G
Sbjct: 963 EGEGEEEGEG 972



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 44/184 (23%), Positives = 69/184 (37%), Gaps = 10/184 (5%)

Query: 243 DDNNEEEEDVEMKEDSDENGPEEKQSVEE---MEEQSQDADGVNTVTVPGPASEEAVEDC 299
           DD++E EE  EMKE     G   KQ V +   M + +   +  +   V  P  +E  ED 
Sbjct: 542 DDSDEYEEMSEMKE-----GKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDS 596

Query: 300 KDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQ 359
           K     + E       V  H  R +       +D   ++ ++      S  E E+    +
Sbjct: 597 KGNGIEEQEVEANEENVKVHGGRKEKTEI--LSDDLTDKAEVSEGKAKSVGEAEDGPEGR 654

Query: 360 EDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDEAKE 419
            D    E        +D+E ++GEK  G      PG+ E     +       G + E KE
Sbjct: 655 GDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKE 714

Query: 420 QRNG 423
           +  G
Sbjct: 715 REQG 718



 Score = 37.4 bits (85), Expect = 0.026
 Identities = 43/190 (22%), Positives = 74/190 (38%), Gaps = 14/190 (7%)

Query: 243  DDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDE 302
            +   EEE +    E+  E G  E +  E   E  ++ +G           EE  E   +E
Sbjct: 855  EGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEE 914

Query: 303  DFAKDENITKGGEVTDHSVRDQDHPDGQ--ENDSTKNEIKIETESQSSYMETEE------ 354
            +  + +   +G E       ++   +G+  E +  + E + E E +    E EE      
Sbjct: 915  EEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEG 974

Query: 355  ---LSSNQEDAVIVEQPEVIPLTEDQEEKEG-EKAPGEDTPRMPGKSEGSSDLENTPGPD 410
                   +E+    E  E     E +EE EG E+  GE      G+ EG  ++E   G  
Sbjct: 975  EEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEG--EVEGEEGEG 1032

Query: 411  AGAQDEAKEQ 420
             G ++E +E+
Sbjct: 1033 EGEEEEGEEE 1042



 Score = 37.4 bits (85), Expect = 0.026
 Identities = 38/153 (24%), Positives = 68/153 (44%), Gaps = 16/153 (10%)

Query: 248  EEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKD 307
            EEE+ E  E  +E   E ++   E EE+  + +G           EE  E+ ++E   ++
Sbjct: 958  EEEEGE-GEGEEEGEGEGEEGEGEGEEEEGEGEG---------EEEEGEEEGEEEGEGEE 1007

Query: 308  ENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQ 367
            E   +G E  +  V  +   +  E +  + E + E E +    E EE   N+E     E+
Sbjct: 1008 EGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNRE-----EE 1062

Query: 368  PEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGS 400
             E     ++  E+E E+  GE+  ++  K +GS
Sbjct: 1063 EEEEGKYQETGEEENERQDGEEYKKV-SKIKGS 1094



 Score = 36.2 bits (82), Expect = 0.058
 Identities = 43/180 (23%), Positives = 77/180 (42%), Gaps = 16/180 (8%)

Query: 244  DNNEEEEDVEMKEDSDENGPEEK---QSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCK 300
            +  EEE + E +E+ +  G EE+   +  EE E + ++ +G       G   EE  E   
Sbjct: 877  EGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEG------EGKGEEEGEEG-- 928

Query: 301  DEDFAKDENITKGGEVTDHSVRDQDHPDGQENDST---KNEIKIETESQSSYMETEELSS 357
            + +  ++E   +G +       ++   +G+E +     + E + E E      E EE   
Sbjct: 929  EGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEG 988

Query: 358  NQEDAVIVEQPEVIPLTEDQEEKEG-EKAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDE 416
              E+    E+ E     E++ E EG E+  GE    + G+ EG  + E   G + G + E
Sbjct: 989  EGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGE-EGEGEGEEEEGEEEGEERE 1047



 Score = 35.8 bits (81), Expect = 0.076
 Identities = 45/190 (23%), Positives = 76/190 (40%), Gaps = 31/190 (16%)

Query: 230 KIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPG 289
           ++ + K       +D  E   D   +E S  +G E  Q  +E  E+ +   G   +  PG
Sbjct: 635 EVSEGKAKSVGEAEDGPEGRGDGTCEEGS--SGAEHWQ--DEEREKGEKDKGRGEMERPG 690

Query: 290 PASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSY 349
              +E  E        K+E   + GE  +   R+Q H         +N+ ++E   +  +
Sbjct: 691 EGEKELAE--------KEEWKKRDGEEQEQKEREQGH------QKERNQ-EMEEGGEEEH 735

Query: 350 METEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGP 409
            E EE   ++E+    E+ E     E +EE EGE+  GE       K EG    E   G 
Sbjct: 736 GEGEEEEGDREEE---EEKE----GEGKEEGEGEEVEGERE-----KEEGERKKEERAGK 783

Query: 410 DAGAQDEAKE 419
           +   ++E  +
Sbjct: 784 EEKGEEEGDQ 793



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 34/120 (28%), Positives = 53/120 (44%), Gaps = 20/120 (16%)

Query: 244  DNNEEEEDVE-MKEDSDENGPEEKQSVEEME-EQSQDADGVNTVTVPGPASEEAVEDCKD 301
            +  EEE + E  +E+ +E G EE +  EE E E  ++ +G     V G   E   E+ + 
Sbjct: 980  EGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEG 1039

Query: 302  EDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQED 361
            E+  + E   K GE             G+EN   + E   E E +  Y ET E  + ++D
Sbjct: 1040 EE--EGEEREKEGE-------------GEENRRNREE---EEEEEGKYQETGEEENERQD 1081



 Score = 31.2 bits (69), Expect = 1.9
 Identities = 19/73 (26%), Positives = 37/73 (50%), Gaps = 3/73 (4%)

Query: 243  DDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDE 302
            ++  E E + E++ +  E   EE++  EE EE+ ++ +G           EE  E+ K +
Sbjct: 1014 EEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEEN---RRNREEEEEEEGKYQ 1070

Query: 303  DFAKDENITKGGE 315
            +  ++EN  + GE
Sbjct: 1071 ETGEEENERQDGE 1083


>gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1
           precursor [Homo sapiens]
          Length = 513

 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 50/219 (22%), Positives = 87/219 (39%), Gaps = 37/219 (16%)

Query: 230 KIYKKKM----NEFFSVDDNNEEEEDVEMKEDSDENG---------PEEKQSVEEMEEQS 276
           KI++K      ++   +DDNN  EE   +K DS EN          P      +  E+  
Sbjct: 266 KIFRKSRISEEDDRSELDDNNTMEE---VKSDSTENSNSRDTGLSQPRRDSKGDSQEDSK 322

Query: 277 QDADGVNTVTVPGPASEEAVE--------DCKDEDFAKDENITKGGEVTDHSVRDQDHPD 328
           ++     +  V GP+SE + E          + ++    E+     + T   V DQ+  D
Sbjct: 323 ENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSD 382

Query: 329 GQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGE 388
             E DS+      ++ES+    ++E   S        E PE     E+   +EG ++   
Sbjct: 383 SSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPE----DENSSSQEGLQSHS- 437

Query: 389 DTPRMPGKSEGSSDLENTPGPDAGAQD--EAKEQRNGTK 425
                   +E  S+  ++   D+ +QD   +KE  N T+
Sbjct: 438 ------SSAESQSEESHSEEDDSDSQDSSRSKEDSNSTE 470



 Score = 36.2 bits (82), Expect = 0.058
 Identities = 25/110 (22%), Positives = 52/110 (47%), Gaps = 6/110 (5%)

Query: 252 VEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENIT 311
           VE +EDSD +  +   ++   + +S++    +  +     SEE+ E  +DE+ +  E + 
Sbjct: 375 VEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQ 434

Query: 312 KGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQED 361
                 + S  ++ H +  ++DS  +     + S+     TE  SS++ED
Sbjct: 435 SHSSSAE-SQSEESHSEEDDSDSQDS-----SRSKEDSNSTESKSSSEED 478



 Score = 33.9 bits (76), Expect = 0.29
 Identities = 39/173 (22%), Positives = 72/173 (41%), Gaps = 20/173 (11%)

Query: 243 DDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDE 302
           DD+ ++  D    +D    GP+++Q          D D  +T+     ASEE+    + +
Sbjct: 103 DDDEDDSGDDTFGDDDSGPGPKDRQEGGN-SRLGSDEDSDDTI----QASEESAP--QGQ 155

Query: 303 DFAKDENITKGGEVTDHSVRDQDHPDG----QENDSTKNEIKIETESQSSYMETEELSSN 358
           D A+D   T      D+  R    P+G    QE++S ++ +   ++ +SS+ +  EL   
Sbjct: 156 DSAQD--TTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSEL--- 210

Query: 359 QEDAVIVEQPEVIPLTEDQEEKEG----EKAPGEDTPRMPGKSEGSSDLENTP 407
            ++ +  + PE I                K  GE++ +   +  G S L   P
Sbjct: 211 DDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHP 263



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 42/211 (19%), Positives = 85/211 (40%), Gaps = 25/211 (11%)

Query: 237 NEFFSVDDNN----EEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPAS 292
           ++ F  DD+     + +E    +  SDE+  +  Q+ EE   Q QD+    T       +
Sbjct: 111 DDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDN 170

Query: 293 EEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQEND----------STKNEIKIE 342
           E+ V+   +   +  E+ ++   V   S  +  H DG E D          S ++E +  
Sbjct: 171 EDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSE-RGN 229

Query: 343 TESQSSYMETEELSSNQEDA--------VIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMP 394
           +   S+ M+++E   N E A         ++E P      + +  +E +++  +D   M 
Sbjct: 230 SRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTM- 288

Query: 395 GKSEGSSDLENTPGPDAGAQDEAKEQRNGTK 425
            +   S   EN+   D G     ++ +  ++
Sbjct: 289 -EEVKSDSTENSNSRDTGLSQPRRDSKGDSQ 318


>gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2
           precursor [Homo sapiens]
          Length = 497

 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 50/219 (22%), Positives = 87/219 (39%), Gaps = 37/219 (16%)

Query: 230 KIYKKKM----NEFFSVDDNNEEEEDVEMKEDSDENG---------PEEKQSVEEMEEQS 276
           KI++K      ++   +DDNN  EE   +K DS EN          P      +  E+  
Sbjct: 250 KIFRKSRISEEDDRSELDDNNTMEE---VKSDSTENSNSRDTGLSQPRRDSKGDSQEDSK 306

Query: 277 QDADGVNTVTVPGPASEEAVE--------DCKDEDFAKDENITKGGEVTDHSVRDQDHPD 328
           ++     +  V GP+SE + E          + ++    E+     + T   V DQ+  D
Sbjct: 307 ENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSD 366

Query: 329 GQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGE 388
             E DS+      ++ES+    ++E   S        E PE     E+   +EG ++   
Sbjct: 367 SSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPE----DENSSSQEGLQSHS- 421

Query: 389 DTPRMPGKSEGSSDLENTPGPDAGAQD--EAKEQRNGTK 425
                   +E  S+  ++   D+ +QD   +KE  N T+
Sbjct: 422 ------SSAESQSEESHSEEDDSDSQDSSRSKEDSNSTE 454



 Score = 36.2 bits (82), Expect = 0.058
 Identities = 25/110 (22%), Positives = 52/110 (47%), Gaps = 6/110 (5%)

Query: 252 VEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENIT 311
           VE +EDSD +  +   ++   + +S++    +  +     SEE+ E  +DE+ +  E + 
Sbjct: 359 VEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQ 418

Query: 312 KGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQED 361
                 + S  ++ H +  ++DS  +     + S+     TE  SS++ED
Sbjct: 419 SHSSSAE-SQSEESHSEEDDSDSQDS-----SRSKEDSNSTESKSSSEED 462



 Score = 33.9 bits (76), Expect = 0.29
 Identities = 39/173 (22%), Positives = 72/173 (41%), Gaps = 20/173 (11%)

Query: 243 DDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDE 302
           DD+ ++  D    +D    GP+++Q          D D  +T+     ASEE+    + +
Sbjct: 87  DDDEDDSGDDTFGDDDSGPGPKDRQEGGN-SRLGSDEDSDDTI----QASEESAP--QGQ 139

Query: 303 DFAKDENITKGGEVTDHSVRDQDHPDG----QENDSTKNEIKIETESQSSYMETEELSSN 358
           D A+D   T      D+  R    P+G    QE++S ++ +   ++ +SS+ +  EL   
Sbjct: 140 DSAQD--TTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSEL--- 194

Query: 359 QEDAVIVEQPEVIPLTEDQEEKEG----EKAPGEDTPRMPGKSEGSSDLENTP 407
            ++ +  + PE I                K  GE++ +   +  G S L   P
Sbjct: 195 DDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHP 247



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 42/211 (19%), Positives = 85/211 (40%), Gaps = 25/211 (11%)

Query: 237 NEFFSVDDNN----EEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPAS 292
           ++ F  DD+     + +E    +  SDE+  +  Q+ EE   Q QD+    T       +
Sbjct: 95  DDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDN 154

Query: 293 EEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQEND----------STKNEIKIE 342
           E+ V+   +   +  E+ ++   V   S  +  H DG E D          S ++E +  
Sbjct: 155 EDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSE-RGN 213

Query: 343 TESQSSYMETEELSSNQEDA--------VIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMP 394
           +   S+ M+++E   N E A         ++E P      + +  +E +++  +D   M 
Sbjct: 214 SRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTM- 272

Query: 395 GKSEGSSDLENTPGPDAGAQDEAKEQRNGTK 425
            +   S   EN+   D G     ++ +  ++
Sbjct: 273 -EEVKSDSTENSNSRDTGLSQPRRDSKGDSQ 302


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
           [Homo sapiens]
          Length = 916

 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 47/200 (23%), Positives = 84/200 (42%), Gaps = 18/200 (9%)

Query: 225 LEVDFKIYKKKMNEFFSVDDNNEEEED---------VEMKEDSDENGPEEKQSVEEMEEQ 275
           L+V  K  ++ + E    D+ +E EE          V MKE+  E   E+++  E  EE+
Sbjct: 446 LKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEE 505

Query: 276 SQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDST 335
                     T P    EE  ++  +E+  ++E     G  +D +       +G      
Sbjct: 506 VAAKKSPVKATAPEVKEEEGEKE--EEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEE 563

Query: 336 KNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVI---PLTEDQEEKEGEKAPGEDTPR 392
             + + ETE+++   E EE  + +E  V  +  EV     L  D + ++ EKA     P+
Sbjct: 564 GEQEEGETEAEA---EGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAK-SPVPK 619

Query: 393 MPGKSEGSSDLENTPGPDAG 412
            P + +G S +  +P  + G
Sbjct: 620 SPVEEKGKSPVPKSPVEEKG 639



 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 46/178 (25%), Positives = 77/178 (43%), Gaps = 10/178 (5%)

Query: 247 EEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAK 306
           EEEED   K D  E G  EK+   E EE  Q+ +G       G  + EA E+ K E+   
Sbjct: 536 EEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQE-EGETEAEAEGEEA-EAKEEKKVEE-KS 592

Query: 307 DENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVE 366
           +E  TK   V D  V   + P+  ++   K+ ++ + +S       EE   +      VE
Sbjct: 593 EEVATKEELVADAKV---EKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVE 649

Query: 367 QPEVIPLTEDQEEKEGE----KAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDEAKEQ 420
           +    P+ +   E++G+    K+P E+  + P       + ++      G Q E +E+
Sbjct: 650 EKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEK 707



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 47/208 (22%), Positives = 82/208 (39%), Gaps = 30/208 (14%)

Query: 225 LEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNT 284
           L V  K  KK+  E    +   EEEE    K       PE K+   E EE+    +    
Sbjct: 480 LAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEE---- 535

Query: 285 VTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETE 344
                       E+ +DE    D+    G E    S +++   +  E ++     + E +
Sbjct: 536 ------------EEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK 583

Query: 345 SQSSYMETEELSSNQEDAVI---VEQPEVI--PLTEDQEEKEGE----KAPGED-----T 390
            +    E  E  + +E+ V    VE+PE    P+ +   E++G+    K+P E+      
Sbjct: 584 EEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV 643

Query: 391 PRMPGKSEGSSDLENTPGPDAGAQDEAK 418
           P+ P + +G S +  +P  + G    +K
Sbjct: 644 PKSPVEEKGKSPVPKSPVEEKGKSPVSK 671



 Score = 36.2 bits (82), Expect = 0.058
 Identities = 45/180 (25%), Positives = 82/180 (45%), Gaps = 26/180 (14%)

Query: 247 EEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAK 306
           +EEE+ E+KE      P+E + VE+ EE+ +D           P  ++A    K+E  A+
Sbjct: 702 KEEEEKEVKE-----APKE-EKVEKKEEKPKDV----------PEKKKAESPVKEEAVAE 745

Query: 307 DENITKGGEV-TDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIV 365
              ITK  +V  +   +++  P  QE +  K   +  +E + S  +     S +ED  + 
Sbjct: 746 VVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGS--DKGAKGSRKEDIAVN 803

Query: 366 EQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDEAKEQRNGTK 425
            + E     E+ E++  EK  G    R   K   ++ L+ +P  +    D+++E+   TK
Sbjct: 804 GEVEG---KEEVEQETKEKGSG----REEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTK 856



 Score = 33.5 bits (75), Expect = 0.38
 Identities = 31/138 (22%), Positives = 59/138 (42%), Gaps = 14/138 (10%)

Query: 293 EEAVEDCK--DEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYM 350
           EE +E+ K  DE    +E +T   E    S++++     +E +      + E  ++ S +
Sbjct: 454 EEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPV 513

Query: 351 ETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLE------ 404
           +       +E+    E+       +++EE+E E A  +       + EGSS+ E      
Sbjct: 514 KATAPEVKEEEGEKEEEEG-----QEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEE 568

Query: 405 -NTPGPDAGAQDEAKEQR 421
             T     G + EAKE++
Sbjct: 569 GETEAEAEGEEAEAKEEK 586


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.307    0.129    0.365 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,321,793
Number of Sequences: 37866
Number of extensions: 938998
Number of successful extensions: 10572
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 238
Number of HSP's successfully gapped in prelim test: 496
Number of HSP's that attempted gapping in prelim test: 5921
Number of HSP's gapped (non-prelim): 3043
length of query: 425
length of database: 18,247,518
effective HSP length: 105
effective length of query: 320
effective length of database: 14,271,588
effective search space: 4566908160
effective search space used: 4566908160
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.