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Search of human proteins with 239748581
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239748581 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
(1873 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239754054 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 3744 0.0
gi|239748581 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 3744 0.0
gi|239742600 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 3744 0.0
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 132 4e-30
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 128 5e-29
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 128 5e-29
gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens] 105 3e-22
gi|188219549 ankyrin repeat domain 32 [Homo sapiens] 92 6e-18
gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens] 90 2e-17
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ... 86 3e-16
gi|28605137 proteasome 26S non-ATPase subunit 10 isform 2 [Homo ... 85 8e-16
gi|183396783 BCL-6 interacting corepressor isoform a [Homo sapiens] 85 8e-16
gi|183396787 BCL-6 interacting corepressor isoform c [Homo sapiens] 85 8e-16
gi|183396785 BCL-6 interacting corepressor isoform b [Homo sapiens] 85 8e-16
gi|21071037 BCL-6 interacting corepressor isoform a [Homo sapiens] 85 8e-16
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 82 4e-15
gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens] 82 5e-15
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 82 6e-15
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 80 1e-14
gi|18079216 CASK interacting protein 1 [Homo sapiens] 80 2e-14
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 79 3e-14
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 79 3e-14
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 79 3e-14
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 79 3e-14
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 79 3e-14
gi|33286442 BCL6 co-repressor-like 1 [Homo sapiens] 79 4e-14
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 78 9e-14
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 78 9e-14
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 78 9e-14
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho... 78 9e-14
>gi|239754054 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 3744 bits (9708), Expect = 0.0
Identities = 1873/1873 (100%), Positives = 1873/1873 (100%)
Query: 1 MEEGVQAPDWDSDETVIEGSVTESDLEEKELPWRRLLFDQDASLKSEFSLHPDTRGMCKG 60
MEEGVQAPDWDSDETVIEGSVTESDLEEKELPWRRLLFDQDASLKSEFSLHPDTRGMCKG
Sbjct: 1 MEEGVQAPDWDSDETVIEGSVTESDLEEKELPWRRLLFDQDASLKSEFSLHPDTRGMCKG 60
Query: 61 MPSPEIQLGFKLREDLQEQMNKNKMMPVLSEDTILQSQDETERNQALLQTRKNCSMFIGS 120
MPSPEIQLGFKLREDLQEQMNKNKMMPVLSEDTILQSQDETERNQALLQTRKNCSMFIGS
Sbjct: 61 MPSPEIQLGFKLREDLQEQMNKNKMMPVLSEDTILQSQDETERNQALLQTRKNCSMFIGS 120
Query: 121 FRQSGLSLNHQNIEGPEAESPEVLPHIEKELSEGRDSPEVSLLSGTAITVSDTVAVKETS 180
FRQSGLSLNHQNIEGPEAESPEVLPHIEKELSEGRDSPEVSLLSGTAITVSDTVAVKETS
Sbjct: 121 FRQSGLSLNHQNIEGPEAESPEVLPHIEKELSEGRDSPEVSLLSGTAITVSDTVAVKETS 180
Query: 181 LVEPEKILAAPNTFFEPRKEVTMTMTSEETKDEESSLETFVSALESLLTSPESTQEERLF 240
LVEPEKILAAPNTFFEPRKEVTMTMTSEETKDEESSLETFVSALESLLTSPESTQEERLF
Sbjct: 181 LVEPEKILAAPNTFFEPRKEVTMTMTSEETKDEESSLETFVSALESLLTSPESTQEERLF 240
Query: 241 ELVSDFDRKELMNPLSDSLSSISIPLNSWSACHRDLLEDAKDDALPAELLEALNTLSEAK 300
ELVSDFDRKELMNPLSDSLSSISIPLNSWSACHRDLLEDAKDDALPAELLEALNTLSEAK
Sbjct: 241 ELVSDFDRKELMNPLSDSLSSISIPLNSWSACHRDLLEDAKDDALPAELLEALNTLSEAK 300
Query: 301 VETICHRKEGGSSLIARNECLEVEFNTSQTNEDCTQIAETLQDPNPSGLQTLAHQNITSC 360
VETICHRKEGGSSLIARNECLEVEFNTSQTNEDCTQIAETLQDPNPSGLQTLAHQNITSC
Sbjct: 301 VETICHRKEGGSSLIARNECLEVEFNTSQTNEDCTQIAETLQDPNPSGLQTLAHQNITSC 360
Query: 361 EPLSNKRNSNSVTNSSDQETACVLRRSSRLEKLKVSRDAKYSDHMYKMPEKILPKILGCE 420
EPLSNKRNSNSVTNSSDQETACVLRRSSRLEKLKVSRDAKYSDHMYKMPEKILPKILGCE
Sbjct: 361 EPLSNKRNSNSVTNSSDQETACVLRRSSRLEKLKVSRDAKYSDHMYKMPEKILPKILGCE 420
Query: 421 DLTNNNSSAQNFRMQDPALMIDGKEKNMHSARFKNGKQIRKNEQFSGKKEKMKVNKISLH 480
DLTNNNSSAQNFRMQDPALMIDGKEKNMHSARFKNGKQIRKNEQFSGKKEKMKVNKISLH
Sbjct: 421 DLTNNNSSAQNFRMQDPALMIDGKEKNMHSARFKNGKQIRKNEQFSGKKEKMKVNKISLH 480
Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE
Sbjct: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM 600
LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM
Sbjct: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM 600
Query: 601 KRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKKPKFSSKSHIWHVYNENSNRQKLEH 660
KRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKKPKFSSKSHIWHVYNENSNRQKLEH
Sbjct: 601 KRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKKPKFSSKSHIWHVYNENSNRQKLEH 660
Query: 661 VKVNKGSKASLFINKEDVYEYYQKDPKNTKFGKSKHKQSTLDQIYSTGLRKGNLHNVKDP 720
VKVNKGSKASLFINKEDVYEYYQKDPKNTKFGKSKHKQSTLDQIYSTGLRKGNLHNVKDP
Sbjct: 661 VKVNKGSKASLFINKEDVYEYYQKDPKNTKFGKSKHKQSTLDQIYSTGLRKGNLHNVKDP 720
Query: 721 NTNVPKGIGRRKTQHKRTQVDDVDCNPRKILAVSPSRRINRLVTYQQHIPETHNDLPEEL 780
NTNVPKGIGRRKTQHKRTQVDDVDCNPRKILAVSPSRRINRLVTYQQHIPETHNDLPEEL
Sbjct: 721 NTNVPKGIGRRKTQHKRTQVDDVDCNPRKILAVSPSRRINRLVTYQQHIPETHNDLPEEL 780
Query: 781 CEPSSLTLSSLRNGLDSSTEACSVSKEKHIQNLDLSDSQEVQCLELESVDQTEAVSFPGL 840
CEPSSLTLSSLRNGLDSSTEACSVSKEKHIQNLDLSDSQEVQCLELESVDQTEAVSFPGL
Sbjct: 781 CEPSSLTLSSLRNGLDSSTEACSVSKEKHIQNLDLSDSQEVQCLELESVDQTEAVSFPGL 840
Query: 841 LLHKEIKLPVVTTDKQPHTLQEQHHVLYKSHENSNLVPKDERFNKWENSFLSFVKENSDN 900
LLHKEIKLPVVTTDKQPHTLQEQHHVLYKSHENSNLVPKDERFNKWENSFLSFVKENSDN
Sbjct: 841 LLHKEIKLPVVTTDKQPHTLQEQHHVLYKSHENSNLVPKDERFNKWENSFLSFVKENSDN 900
Query: 901 DDDDDCSTSEKAITSKKVLCSTGGKKHYNFKENLTNKKEMGFQQFLLSEDHLSQENELKA 960
DDDDDCSTSEKAITSKKVLCSTGGKKHYNFKENLTNKKEMGFQQFLLSEDHLSQENELKA
Sbjct: 901 DDDDDCSTSEKAITSKKVLCSTGGKKHYNFKENLTNKKEMGFQQFLLSEDHLSQENELKA 960
Query: 961 VSLTTLPEQEAVNFSYSDNAVISEHVANYEQCIFGPSFDHSNGNPEQNSLACMRTLLTHE 1020
VSLTTLPEQEAVNFSYSDNAVISEHVANYEQCIFGPSFDHSNGNPEQNSLACMRTLLTHE
Sbjct: 961 VSLTTLPEQEAVNFSYSDNAVISEHVANYEQCIFGPSFDHSNGNPEQNSLACMRTLLTHE 1020
Query: 1021 ASKLTNHVELFKKPQDYIPRAPTFLMNQTDTHIVEKMAKNCDTERNYIDRDQKIIYSNEP 1080
ASKLTNHVELFKKPQDYIPRAPTFLMNQTDTHIVEKMAKNCDTERNYIDRDQKIIYSNEP
Sbjct: 1021 ASKLTNHVELFKKPQDYIPRAPTFLMNQTDTHIVEKMAKNCDTERNYIDRDQKIIYSNEP 1080
Query: 1081 LSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSKELANISKLSQREKKEISHK 1140
LSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSKELANISKLSQREKKEISHK
Sbjct: 1081 LSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSKELANISKLSQREKKEISHK 1140
Query: 1141 PGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGS 1200
PGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGS
Sbjct: 1141 PGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGS 1200
Query: 1201 IDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDE 1260
IDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDE
Sbjct: 1201 IDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDE 1260
Query: 1261 ADDEKMKELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQE 1320
ADDEKMKELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQE
Sbjct: 1261 ADDEKMKELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQE 1320
Query: 1321 RSRESLSVHQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQKA 1380
RSRESLSVHQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQKA
Sbjct: 1321 RSRESLSVHQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQKA 1380
Query: 1381 ERDDLAKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCRNVTSLPC 1440
ERDDLAKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCRNVTSLPC
Sbjct: 1381 ERDDLAKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCRNVTSLPC 1440
Query: 1441 LSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWNYSQNTNI 1500
LSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWNYSQNTNI
Sbjct: 1441 LSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWNYSQNTNI 1500
Query: 1501 CLNSEAVRRGEFSGNDMNSKQNGSDCTLDGFPKSRHSDGTEKNKLPSQPVAFIGQTEYSQ 1560
CLNSEAVRRGEFSGNDMNSKQNGSDCTLDGFPKSRHSDGTEKNKLPSQPVAFIGQTEYSQ
Sbjct: 1501 CLNSEAVRRGEFSGNDMNSKQNGSDCTLDGFPKSRHSDGTEKNKLPSQPVAFIGQTEYSQ 1560
Query: 1561 KENDLTEATDKDHEFYVSSPVIGKLNISETASVLAENAAHPSNIICDQDLSNYDPKRGNR 1620
KENDLTEATDKDHEFYVSSPVIGKLNISETASVLAENAAHPSNIICDQDLSNYDPKRGNR
Sbjct: 1561 KENDLTEATDKDHEFYVSSPVIGKLNISETASVLAENAAHPSNIICDQDLSNYDPKRGNR 1620
Query: 1621 KTSSQQSPTGASESLAHQGIAVLGSDTVHQMKPYLKKSVSVVPCADDSQISSSSGSGQQD 1680
KTSSQQSPTGASESLAHQGIAVLGSDTVHQMKPYLKKSVSVVPCADDSQISSSSGSGQQD
Sbjct: 1621 KTSSQQSPTGASESLAHQGIAVLGSDTVHQMKPYLKKSVSVVPCADDSQISSSSGSGQQD 1680
Query: 1681 TIKKALNYSTAPKKKCIQIKDLILLGRINPGNNILEFKTQETTHKASILLNGKLKVESGQ 1740
TIKKALNYSTAPKKKCIQIKDLILLGRINPGNNILEFKTQETTHKASILLNGKLKVESGQ
Sbjct: 1681 TIKKALNYSTAPKKKCIQIKDLILLGRINPGNNILEFKTQETTHKASILLNGKLKVESGQ 1740
Query: 1741 IYKNPVTWLKDLLGGNSYVTWNYAWSKVTYLGKELLRYVSEDAPILPEPNSVPQQYQPCL 1800
IYKNPVTWLKDLLGGNSYVTWNYAWSKVTYLGKELLRYVSEDAPILPEPNSVPQQYQPCL
Sbjct: 1741 IYKNPVTWLKDLLGGNSYVTWNYAWSKVTYLGKELLRYVSEDAPILPEPNSVPQQYQPCL 1800
Query: 1801 PEVACLDDPVQEPNKSMFEKTKFGQGTSRESMQSSPRYLQINEILLISDQEFLPCHIMDQ 1860
PEVACLDDPVQEPNKSMFEKTKFGQGTSRESMQSSPRYLQINEILLISDQEFLPCHIMDQ
Sbjct: 1801 PEVACLDDPVQEPNKSMFEKTKFGQGTSRESMQSSPRYLQINEILLISDQEFLPCHIMDQ 1860
Query: 1861 HWKFCVECEELTP 1873
HWKFCVECEELTP
Sbjct: 1861 HWKFCVECEELTP 1873
>gi|239748581 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 3744 bits (9708), Expect = 0.0
Identities = 1873/1873 (100%), Positives = 1873/1873 (100%)
Query: 1 MEEGVQAPDWDSDETVIEGSVTESDLEEKELPWRRLLFDQDASLKSEFSLHPDTRGMCKG 60
MEEGVQAPDWDSDETVIEGSVTESDLEEKELPWRRLLFDQDASLKSEFSLHPDTRGMCKG
Sbjct: 1 MEEGVQAPDWDSDETVIEGSVTESDLEEKELPWRRLLFDQDASLKSEFSLHPDTRGMCKG 60
Query: 61 MPSPEIQLGFKLREDLQEQMNKNKMMPVLSEDTILQSQDETERNQALLQTRKNCSMFIGS 120
MPSPEIQLGFKLREDLQEQMNKNKMMPVLSEDTILQSQDETERNQALLQTRKNCSMFIGS
Sbjct: 61 MPSPEIQLGFKLREDLQEQMNKNKMMPVLSEDTILQSQDETERNQALLQTRKNCSMFIGS 120
Query: 121 FRQSGLSLNHQNIEGPEAESPEVLPHIEKELSEGRDSPEVSLLSGTAITVSDTVAVKETS 180
FRQSGLSLNHQNIEGPEAESPEVLPHIEKELSEGRDSPEVSLLSGTAITVSDTVAVKETS
Sbjct: 121 FRQSGLSLNHQNIEGPEAESPEVLPHIEKELSEGRDSPEVSLLSGTAITVSDTVAVKETS 180
Query: 181 LVEPEKILAAPNTFFEPRKEVTMTMTSEETKDEESSLETFVSALESLLTSPESTQEERLF 240
LVEPEKILAAPNTFFEPRKEVTMTMTSEETKDEESSLETFVSALESLLTSPESTQEERLF
Sbjct: 181 LVEPEKILAAPNTFFEPRKEVTMTMTSEETKDEESSLETFVSALESLLTSPESTQEERLF 240
Query: 241 ELVSDFDRKELMNPLSDSLSSISIPLNSWSACHRDLLEDAKDDALPAELLEALNTLSEAK 300
ELVSDFDRKELMNPLSDSLSSISIPLNSWSACHRDLLEDAKDDALPAELLEALNTLSEAK
Sbjct: 241 ELVSDFDRKELMNPLSDSLSSISIPLNSWSACHRDLLEDAKDDALPAELLEALNTLSEAK 300
Query: 301 VETICHRKEGGSSLIARNECLEVEFNTSQTNEDCTQIAETLQDPNPSGLQTLAHQNITSC 360
VETICHRKEGGSSLIARNECLEVEFNTSQTNEDCTQIAETLQDPNPSGLQTLAHQNITSC
Sbjct: 301 VETICHRKEGGSSLIARNECLEVEFNTSQTNEDCTQIAETLQDPNPSGLQTLAHQNITSC 360
Query: 361 EPLSNKRNSNSVTNSSDQETACVLRRSSRLEKLKVSRDAKYSDHMYKMPEKILPKILGCE 420
EPLSNKRNSNSVTNSSDQETACVLRRSSRLEKLKVSRDAKYSDHMYKMPEKILPKILGCE
Sbjct: 361 EPLSNKRNSNSVTNSSDQETACVLRRSSRLEKLKVSRDAKYSDHMYKMPEKILPKILGCE 420
Query: 421 DLTNNNSSAQNFRMQDPALMIDGKEKNMHSARFKNGKQIRKNEQFSGKKEKMKVNKISLH 480
DLTNNNSSAQNFRMQDPALMIDGKEKNMHSARFKNGKQIRKNEQFSGKKEKMKVNKISLH
Sbjct: 421 DLTNNNSSAQNFRMQDPALMIDGKEKNMHSARFKNGKQIRKNEQFSGKKEKMKVNKISLH 480
Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE
Sbjct: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM 600
LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM
Sbjct: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM 600
Query: 601 KRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKKPKFSSKSHIWHVYNENSNRQKLEH 660
KRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKKPKFSSKSHIWHVYNENSNRQKLEH
Sbjct: 601 KRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKKPKFSSKSHIWHVYNENSNRQKLEH 660
Query: 661 VKVNKGSKASLFINKEDVYEYYQKDPKNTKFGKSKHKQSTLDQIYSTGLRKGNLHNVKDP 720
VKVNKGSKASLFINKEDVYEYYQKDPKNTKFGKSKHKQSTLDQIYSTGLRKGNLHNVKDP
Sbjct: 661 VKVNKGSKASLFINKEDVYEYYQKDPKNTKFGKSKHKQSTLDQIYSTGLRKGNLHNVKDP 720
Query: 721 NTNVPKGIGRRKTQHKRTQVDDVDCNPRKILAVSPSRRINRLVTYQQHIPETHNDLPEEL 780
NTNVPKGIGRRKTQHKRTQVDDVDCNPRKILAVSPSRRINRLVTYQQHIPETHNDLPEEL
Sbjct: 721 NTNVPKGIGRRKTQHKRTQVDDVDCNPRKILAVSPSRRINRLVTYQQHIPETHNDLPEEL 780
Query: 781 CEPSSLTLSSLRNGLDSSTEACSVSKEKHIQNLDLSDSQEVQCLELESVDQTEAVSFPGL 840
CEPSSLTLSSLRNGLDSSTEACSVSKEKHIQNLDLSDSQEVQCLELESVDQTEAVSFPGL
Sbjct: 781 CEPSSLTLSSLRNGLDSSTEACSVSKEKHIQNLDLSDSQEVQCLELESVDQTEAVSFPGL 840
Query: 841 LLHKEIKLPVVTTDKQPHTLQEQHHVLYKSHENSNLVPKDERFNKWENSFLSFVKENSDN 900
LLHKEIKLPVVTTDKQPHTLQEQHHVLYKSHENSNLVPKDERFNKWENSFLSFVKENSDN
Sbjct: 841 LLHKEIKLPVVTTDKQPHTLQEQHHVLYKSHENSNLVPKDERFNKWENSFLSFVKENSDN 900
Query: 901 DDDDDCSTSEKAITSKKVLCSTGGKKHYNFKENLTNKKEMGFQQFLLSEDHLSQENELKA 960
DDDDDCSTSEKAITSKKVLCSTGGKKHYNFKENLTNKKEMGFQQFLLSEDHLSQENELKA
Sbjct: 901 DDDDDCSTSEKAITSKKVLCSTGGKKHYNFKENLTNKKEMGFQQFLLSEDHLSQENELKA 960
Query: 961 VSLTTLPEQEAVNFSYSDNAVISEHVANYEQCIFGPSFDHSNGNPEQNSLACMRTLLTHE 1020
VSLTTLPEQEAVNFSYSDNAVISEHVANYEQCIFGPSFDHSNGNPEQNSLACMRTLLTHE
Sbjct: 961 VSLTTLPEQEAVNFSYSDNAVISEHVANYEQCIFGPSFDHSNGNPEQNSLACMRTLLTHE 1020
Query: 1021 ASKLTNHVELFKKPQDYIPRAPTFLMNQTDTHIVEKMAKNCDTERNYIDRDQKIIYSNEP 1080
ASKLTNHVELFKKPQDYIPRAPTFLMNQTDTHIVEKMAKNCDTERNYIDRDQKIIYSNEP
Sbjct: 1021 ASKLTNHVELFKKPQDYIPRAPTFLMNQTDTHIVEKMAKNCDTERNYIDRDQKIIYSNEP 1080
Query: 1081 LSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSKELANISKLSQREKKEISHK 1140
LSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSKELANISKLSQREKKEISHK
Sbjct: 1081 LSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSKELANISKLSQREKKEISHK 1140
Query: 1141 PGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGS 1200
PGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGS
Sbjct: 1141 PGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGS 1200
Query: 1201 IDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDE 1260
IDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDE
Sbjct: 1201 IDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDE 1260
Query: 1261 ADDEKMKELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQE 1320
ADDEKMKELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQE
Sbjct: 1261 ADDEKMKELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQE 1320
Query: 1321 RSRESLSVHQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQKA 1380
RSRESLSVHQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQKA
Sbjct: 1321 RSRESLSVHQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQKA 1380
Query: 1381 ERDDLAKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCRNVTSLPC 1440
ERDDLAKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCRNVTSLPC
Sbjct: 1381 ERDDLAKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCRNVTSLPC 1440
Query: 1441 LSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWNYSQNTNI 1500
LSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWNYSQNTNI
Sbjct: 1441 LSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWNYSQNTNI 1500
Query: 1501 CLNSEAVRRGEFSGNDMNSKQNGSDCTLDGFPKSRHSDGTEKNKLPSQPVAFIGQTEYSQ 1560
CLNSEAVRRGEFSGNDMNSKQNGSDCTLDGFPKSRHSDGTEKNKLPSQPVAFIGQTEYSQ
Sbjct: 1501 CLNSEAVRRGEFSGNDMNSKQNGSDCTLDGFPKSRHSDGTEKNKLPSQPVAFIGQTEYSQ 1560
Query: 1561 KENDLTEATDKDHEFYVSSPVIGKLNISETASVLAENAAHPSNIICDQDLSNYDPKRGNR 1620
KENDLTEATDKDHEFYVSSPVIGKLNISETASVLAENAAHPSNIICDQDLSNYDPKRGNR
Sbjct: 1561 KENDLTEATDKDHEFYVSSPVIGKLNISETASVLAENAAHPSNIICDQDLSNYDPKRGNR 1620
Query: 1621 KTSSQQSPTGASESLAHQGIAVLGSDTVHQMKPYLKKSVSVVPCADDSQISSSSGSGQQD 1680
KTSSQQSPTGASESLAHQGIAVLGSDTVHQMKPYLKKSVSVVPCADDSQISSSSGSGQQD
Sbjct: 1621 KTSSQQSPTGASESLAHQGIAVLGSDTVHQMKPYLKKSVSVVPCADDSQISSSSGSGQQD 1680
Query: 1681 TIKKALNYSTAPKKKCIQIKDLILLGRINPGNNILEFKTQETTHKASILLNGKLKVESGQ 1740
TIKKALNYSTAPKKKCIQIKDLILLGRINPGNNILEFKTQETTHKASILLNGKLKVESGQ
Sbjct: 1681 TIKKALNYSTAPKKKCIQIKDLILLGRINPGNNILEFKTQETTHKASILLNGKLKVESGQ 1740
Query: 1741 IYKNPVTWLKDLLGGNSYVTWNYAWSKVTYLGKELLRYVSEDAPILPEPNSVPQQYQPCL 1800
IYKNPVTWLKDLLGGNSYVTWNYAWSKVTYLGKELLRYVSEDAPILPEPNSVPQQYQPCL
Sbjct: 1741 IYKNPVTWLKDLLGGNSYVTWNYAWSKVTYLGKELLRYVSEDAPILPEPNSVPQQYQPCL 1800
Query: 1801 PEVACLDDPVQEPNKSMFEKTKFGQGTSRESMQSSPRYLQINEILLISDQEFLPCHIMDQ 1860
PEVACLDDPVQEPNKSMFEKTKFGQGTSRESMQSSPRYLQINEILLISDQEFLPCHIMDQ
Sbjct: 1801 PEVACLDDPVQEPNKSMFEKTKFGQGTSRESMQSSPRYLQINEILLISDQEFLPCHIMDQ 1860
Query: 1861 HWKFCVECEELTP 1873
HWKFCVECEELTP
Sbjct: 1861 HWKFCVECEELTP 1873
>gi|239742600 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 3744 bits (9708), Expect = 0.0
Identities = 1873/1873 (100%), Positives = 1873/1873 (100%)
Query: 1 MEEGVQAPDWDSDETVIEGSVTESDLEEKELPWRRLLFDQDASLKSEFSLHPDTRGMCKG 60
MEEGVQAPDWDSDETVIEGSVTESDLEEKELPWRRLLFDQDASLKSEFSLHPDTRGMCKG
Sbjct: 1 MEEGVQAPDWDSDETVIEGSVTESDLEEKELPWRRLLFDQDASLKSEFSLHPDTRGMCKG 60
Query: 61 MPSPEIQLGFKLREDLQEQMNKNKMMPVLSEDTILQSQDETERNQALLQTRKNCSMFIGS 120
MPSPEIQLGFKLREDLQEQMNKNKMMPVLSEDTILQSQDETERNQALLQTRKNCSMFIGS
Sbjct: 61 MPSPEIQLGFKLREDLQEQMNKNKMMPVLSEDTILQSQDETERNQALLQTRKNCSMFIGS 120
Query: 121 FRQSGLSLNHQNIEGPEAESPEVLPHIEKELSEGRDSPEVSLLSGTAITVSDTVAVKETS 180
FRQSGLSLNHQNIEGPEAESPEVLPHIEKELSEGRDSPEVSLLSGTAITVSDTVAVKETS
Sbjct: 121 FRQSGLSLNHQNIEGPEAESPEVLPHIEKELSEGRDSPEVSLLSGTAITVSDTVAVKETS 180
Query: 181 LVEPEKILAAPNTFFEPRKEVTMTMTSEETKDEESSLETFVSALESLLTSPESTQEERLF 240
LVEPEKILAAPNTFFEPRKEVTMTMTSEETKDEESSLETFVSALESLLTSPESTQEERLF
Sbjct: 181 LVEPEKILAAPNTFFEPRKEVTMTMTSEETKDEESSLETFVSALESLLTSPESTQEERLF 240
Query: 241 ELVSDFDRKELMNPLSDSLSSISIPLNSWSACHRDLLEDAKDDALPAELLEALNTLSEAK 300
ELVSDFDRKELMNPLSDSLSSISIPLNSWSACHRDLLEDAKDDALPAELLEALNTLSEAK
Sbjct: 241 ELVSDFDRKELMNPLSDSLSSISIPLNSWSACHRDLLEDAKDDALPAELLEALNTLSEAK 300
Query: 301 VETICHRKEGGSSLIARNECLEVEFNTSQTNEDCTQIAETLQDPNPSGLQTLAHQNITSC 360
VETICHRKEGGSSLIARNECLEVEFNTSQTNEDCTQIAETLQDPNPSGLQTLAHQNITSC
Sbjct: 301 VETICHRKEGGSSLIARNECLEVEFNTSQTNEDCTQIAETLQDPNPSGLQTLAHQNITSC 360
Query: 361 EPLSNKRNSNSVTNSSDQETACVLRRSSRLEKLKVSRDAKYSDHMYKMPEKILPKILGCE 420
EPLSNKRNSNSVTNSSDQETACVLRRSSRLEKLKVSRDAKYSDHMYKMPEKILPKILGCE
Sbjct: 361 EPLSNKRNSNSVTNSSDQETACVLRRSSRLEKLKVSRDAKYSDHMYKMPEKILPKILGCE 420
Query: 421 DLTNNNSSAQNFRMQDPALMIDGKEKNMHSARFKNGKQIRKNEQFSGKKEKMKVNKISLH 480
DLTNNNSSAQNFRMQDPALMIDGKEKNMHSARFKNGKQIRKNEQFSGKKEKMKVNKISLH
Sbjct: 421 DLTNNNSSAQNFRMQDPALMIDGKEKNMHSARFKNGKQIRKNEQFSGKKEKMKVNKISLH 480
Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE
Sbjct: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM 600
LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM
Sbjct: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM 600
Query: 601 KRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKKPKFSSKSHIWHVYNENSNRQKLEH 660
KRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKKPKFSSKSHIWHVYNENSNRQKLEH
Sbjct: 601 KRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKKPKFSSKSHIWHVYNENSNRQKLEH 660
Query: 661 VKVNKGSKASLFINKEDVYEYYQKDPKNTKFGKSKHKQSTLDQIYSTGLRKGNLHNVKDP 720
VKVNKGSKASLFINKEDVYEYYQKDPKNTKFGKSKHKQSTLDQIYSTGLRKGNLHNVKDP
Sbjct: 661 VKVNKGSKASLFINKEDVYEYYQKDPKNTKFGKSKHKQSTLDQIYSTGLRKGNLHNVKDP 720
Query: 721 NTNVPKGIGRRKTQHKRTQVDDVDCNPRKILAVSPSRRINRLVTYQQHIPETHNDLPEEL 780
NTNVPKGIGRRKTQHKRTQVDDVDCNPRKILAVSPSRRINRLVTYQQHIPETHNDLPEEL
Sbjct: 721 NTNVPKGIGRRKTQHKRTQVDDVDCNPRKILAVSPSRRINRLVTYQQHIPETHNDLPEEL 780
Query: 781 CEPSSLTLSSLRNGLDSSTEACSVSKEKHIQNLDLSDSQEVQCLELESVDQTEAVSFPGL 840
CEPSSLTLSSLRNGLDSSTEACSVSKEKHIQNLDLSDSQEVQCLELESVDQTEAVSFPGL
Sbjct: 781 CEPSSLTLSSLRNGLDSSTEACSVSKEKHIQNLDLSDSQEVQCLELESVDQTEAVSFPGL 840
Query: 841 LLHKEIKLPVVTTDKQPHTLQEQHHVLYKSHENSNLVPKDERFNKWENSFLSFVKENSDN 900
LLHKEIKLPVVTTDKQPHTLQEQHHVLYKSHENSNLVPKDERFNKWENSFLSFVKENSDN
Sbjct: 841 LLHKEIKLPVVTTDKQPHTLQEQHHVLYKSHENSNLVPKDERFNKWENSFLSFVKENSDN 900
Query: 901 DDDDDCSTSEKAITSKKVLCSTGGKKHYNFKENLTNKKEMGFQQFLLSEDHLSQENELKA 960
DDDDDCSTSEKAITSKKVLCSTGGKKHYNFKENLTNKKEMGFQQFLLSEDHLSQENELKA
Sbjct: 901 DDDDDCSTSEKAITSKKVLCSTGGKKHYNFKENLTNKKEMGFQQFLLSEDHLSQENELKA 960
Query: 961 VSLTTLPEQEAVNFSYSDNAVISEHVANYEQCIFGPSFDHSNGNPEQNSLACMRTLLTHE 1020
VSLTTLPEQEAVNFSYSDNAVISEHVANYEQCIFGPSFDHSNGNPEQNSLACMRTLLTHE
Sbjct: 961 VSLTTLPEQEAVNFSYSDNAVISEHVANYEQCIFGPSFDHSNGNPEQNSLACMRTLLTHE 1020
Query: 1021 ASKLTNHVELFKKPQDYIPRAPTFLMNQTDTHIVEKMAKNCDTERNYIDRDQKIIYSNEP 1080
ASKLTNHVELFKKPQDYIPRAPTFLMNQTDTHIVEKMAKNCDTERNYIDRDQKIIYSNEP
Sbjct: 1021 ASKLTNHVELFKKPQDYIPRAPTFLMNQTDTHIVEKMAKNCDTERNYIDRDQKIIYSNEP 1080
Query: 1081 LSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSKELANISKLSQREKKEISHK 1140
LSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSKELANISKLSQREKKEISHK
Sbjct: 1081 LSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSKELANISKLSQREKKEISHK 1140
Query: 1141 PGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGS 1200
PGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGS
Sbjct: 1141 PGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGS 1200
Query: 1201 IDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDE 1260
IDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDE
Sbjct: 1201 IDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDE 1260
Query: 1261 ADDEKMKELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQE 1320
ADDEKMKELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQE
Sbjct: 1261 ADDEKMKELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQE 1320
Query: 1321 RSRESLSVHQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQKA 1380
RSRESLSVHQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQKA
Sbjct: 1321 RSRESLSVHQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQKA 1380
Query: 1381 ERDDLAKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCRNVTSLPC 1440
ERDDLAKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCRNVTSLPC
Sbjct: 1381 ERDDLAKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCRNVTSLPC 1440
Query: 1441 LSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWNYSQNTNI 1500
LSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWNYSQNTNI
Sbjct: 1441 LSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWNYSQNTNI 1500
Query: 1501 CLNSEAVRRGEFSGNDMNSKQNGSDCTLDGFPKSRHSDGTEKNKLPSQPVAFIGQTEYSQ 1560
CLNSEAVRRGEFSGNDMNSKQNGSDCTLDGFPKSRHSDGTEKNKLPSQPVAFIGQTEYSQ
Sbjct: 1501 CLNSEAVRRGEFSGNDMNSKQNGSDCTLDGFPKSRHSDGTEKNKLPSQPVAFIGQTEYSQ 1560
Query: 1561 KENDLTEATDKDHEFYVSSPVIGKLNISETASVLAENAAHPSNIICDQDLSNYDPKRGNR 1620
KENDLTEATDKDHEFYVSSPVIGKLNISETASVLAENAAHPSNIICDQDLSNYDPKRGNR
Sbjct: 1561 KENDLTEATDKDHEFYVSSPVIGKLNISETASVLAENAAHPSNIICDQDLSNYDPKRGNR 1620
Query: 1621 KTSSQQSPTGASESLAHQGIAVLGSDTVHQMKPYLKKSVSVVPCADDSQISSSSGSGQQD 1680
KTSSQQSPTGASESLAHQGIAVLGSDTVHQMKPYLKKSVSVVPCADDSQISSSSGSGQQD
Sbjct: 1621 KTSSQQSPTGASESLAHQGIAVLGSDTVHQMKPYLKKSVSVVPCADDSQISSSSGSGQQD 1680
Query: 1681 TIKKALNYSTAPKKKCIQIKDLILLGRINPGNNILEFKTQETTHKASILLNGKLKVESGQ 1740
TIKKALNYSTAPKKKCIQIKDLILLGRINPGNNILEFKTQETTHKASILLNGKLKVESGQ
Sbjct: 1681 TIKKALNYSTAPKKKCIQIKDLILLGRINPGNNILEFKTQETTHKASILLNGKLKVESGQ 1740
Query: 1741 IYKNPVTWLKDLLGGNSYVTWNYAWSKVTYLGKELLRYVSEDAPILPEPNSVPQQYQPCL 1800
IYKNPVTWLKDLLGGNSYVTWNYAWSKVTYLGKELLRYVSEDAPILPEPNSVPQQYQPCL
Sbjct: 1741 IYKNPVTWLKDLLGGNSYVTWNYAWSKVTYLGKELLRYVSEDAPILPEPNSVPQQYQPCL 1800
Query: 1801 PEVACLDDPVQEPNKSMFEKTKFGQGTSRESMQSSPRYLQINEILLISDQEFLPCHIMDQ 1860
PEVACLDDPVQEPNKSMFEKTKFGQGTSRESMQSSPRYLQINEILLISDQEFLPCHIMDQ
Sbjct: 1801 PEVACLDDPVQEPNKSMFEKTKFGQGTSRESMQSSPRYLQINEILLISDQEFLPCHIMDQ 1860
Query: 1861 HWKFCVECEELTP 1873
HWKFCVECEELTP
Sbjct: 1861 HWKFCVECEELTP 1873
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 132 bits (331), Expect = 4e-30
Identities = 99/311 (31%), Positives = 147/311 (47%), Gaps = 43/311 (13%)
Query: 1147 RINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVE 1206
++NKRN RGE++LH A RG+ +K LI GADVN+ D AGWT LHEA N G D+ +
Sbjct: 160 KVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQ 219
Query: 1207 LLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKM 1266
LL AGA+VN + +D PLHDA N H K ++LL+ G NP Q ++K ++ L A+ M
Sbjct: 220 LLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVANSPTM 279
Query: 1267 KELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDS---SSLSHQERSR 1323
LL G + +++ E P+ DG DS L H+ ++
Sbjct: 280 VNLLLGKGTYTSSEESSTESSEEEDAPSFAPSSSV-----DGNNTDSEFEKGLKHKAKNP 334
Query: 1324 ESLSVHQTLSAILQDIEEKQE-------------YLLEFEIRNPEDAEQYIE--KMLKIK 1368
E Q +A ++D E E +LL+ + R + +I KM
Sbjct: 335 EP----QKATAPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKS 390
Query: 1369 KIMDNVLAKQKAERDDLA---------------KKYRVSIESFKHGALREQLANLAARQK 1413
+N +A +KA L+ +K R+S + G+ + +N A +QK
Sbjct: 391 YTKNNTIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSN-AKQQK 449
Query: 1414 SLLVVAKKQKK 1424
V KK+KK
Sbjct: 450 EKNKVKKKRKK 460
Score = 117 bits (293), Expect = 1e-25
Identities = 83/230 (36%), Positives = 117/230 (50%), Gaps = 21/230 (9%)
Query: 460 RKNEQFSGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPS 519
+K S K K KVNK RN GE +++AA+ DA + I +G +VN
Sbjct: 147 QKGTPNSASKTKDKVNK--------RNERGETRLHRAAIRGDARRIKELISEGADVNVKD 198
Query: 520 YAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579
+AGWTALHEA G+Y A +LL GA+VN KGL TPLHDA NGHYKV +LLL G
Sbjct: 199 FAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGG 258
Query: 580 DPLFRNDDGKCALDEAKDLCMKRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKKPKF 639
+P N G+ L A M LL + TS++ SS + + ED P F
Sbjct: 259 NPQQSNRKGETPLKVANSPTMVNLL-----LGKGTYTSSEESSTESSEEEDA-----PSF 308
Query: 640 SSKSHIWHVYNENSNRQKLEHVKVN-KGSKASLFINKEDVYEYYQKDPKN 688
+ S + ++ + L+H N + KA+ + +D YE+ + D ++
Sbjct: 309 APSSSVDGNNTDSEFEKGLKHKAKNPEPQKATAPV--KDEYEFDEDDEQD 356
Score = 33.1 bits (74), Expect = 2.6
Identities = 43/168 (25%), Positives = 69/168 (41%), Gaps = 20/168 (11%)
Query: 1133 EKKEISHKPGMKAGRINKRNARGESQL----HLAVRRGNLPL-----VKALIESGADVNL 1183
+K + K G + RI K ++ L L+ R PL V L++ A+ +
Sbjct: 70 QKDSDTEKQGPERKRIKKEPVTRKAGLLFGMGLSGIRAGYPLSERQQVALLMQMTAEESA 129
Query: 1184 NDNAGWTPLHEASN----EGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEI 1239
N TP H + + +G+ + K KVN N G LH A + +
Sbjct: 130 NSPVDTTPKHPSQSTVCQKGTPN---SASKTKDKVNKRNERGETRLHRAAIRGDARRIKE 186
Query: 1240 LLQNGANPNQKDQKQKSALDEADD----EKMKELLRSYGAIETVNRDE 1283
L+ GA+ N KD +AL EA + + K+LL + + T D+
Sbjct: 187 LISEGADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDD 234
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 128 bits (322), Expect = 5e-29
Identities = 114/430 (26%), Positives = 189/430 (43%), Gaps = 51/430 (11%)
Query: 1117 DNMSKELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIE 1176
DN N + +K+ + ++NKRN RGE+ LH+A RG++ VK LI
Sbjct: 124 DNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELIS 183
Query: 1177 SGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKA 1236
GA+VN+ D AGWTPLHEA N G D+ L+ AGA VN + +D PLHD+ ++ H
Sbjct: 184 LGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDI 243
Query: 1237 AEILLQNGANPNQKDQKQKSALDEADDEKMKELLR----------SYGAIETV------- 1279
++LL++G NP Q ++ + +D A+ E+++ LL+ SY E
Sbjct: 244 VKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSS 303
Query: 1280 ------NRDESDAIVNEKIPAVRSKRHKQCFCDD-----------GKTIDSSSLSHQERS 1322
+ E D+++ E + SK D+ K ID + +E+
Sbjct: 304 VDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQR 363
Query: 1323 RESLSVHQTLSAILQDIEEKQEYLLEFEIRNPE-------DAEQYIEKMLKIKKIMDNVL 1375
+E+ + + +EK Y F+ + + E E+ L+ KKI +
Sbjct: 364 KENEPEAEKTHLFAK--QEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCS 421
Query: 1376 AKQKAERDDL--AKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCR 1433
+ D+ K+Y VS E + G ++ +L N +++ + +K+ K + +I N
Sbjct: 422 VIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLT 481
Query: 1434 NVTSLPCLSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWN 1493
T L C K ++ TSL +L H +G S + E Q T
Sbjct: 482 VNTGLDC--SEKTREEGNFRKSFSPKDDTSL-HLFHISTGKSPKHSCGLSEKQ---STPL 535
Query: 1494 YSQNTNICLN 1503
++T CL+
Sbjct: 536 KQEHTKTCLS 545
Score = 104 bits (260), Expect = 7e-22
Identities = 62/174 (35%), Positives = 92/174 (52%), Gaps = 11/174 (6%)
Query: 460 RKNEQFSGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPS 519
+K S ++K KVNK RN GE ++ AA+ D V I G NVN
Sbjct: 141 QKKTPSSSSRQKDKVNK--------RNERGETPLHMAAIRGDVKQVKELISLGANVNVKD 192
Query: 520 YAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579
+AGWT LHEA G+Y A L+ GADVN +GL TPLHD+ +GH + +LLL +G
Sbjct: 193 FAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGG 252
Query: 580 DPLFRNDDGKCALDEAKDLCMKRLLERYIP---KHQKCLTSAQRSSIDPLDIED 630
+P N G+ +D A+ ++ LL+R +P + S + S++P +++
Sbjct: 253 NPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDE 306
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 128 bits (322), Expect = 5e-29
Identities = 114/430 (26%), Positives = 189/430 (43%), Gaps = 51/430 (11%)
Query: 1117 DNMSKELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIE 1176
DN N + +K+ + ++NKRN RGE+ LH+A RG++ VK LI
Sbjct: 147 DNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELIS 206
Query: 1177 SGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKA 1236
GA+VN+ D AGWTPLHEA N G D+ L+ AGA VN + +D PLHD+ ++ H
Sbjct: 207 LGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDI 266
Query: 1237 AEILLQNGANPNQKDQKQKSALDEADDEKMKELLR----------SYGAIETV------- 1279
++LL++G NP Q ++ + +D A+ E+++ LL+ SY E
Sbjct: 267 VKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSS 326
Query: 1280 ------NRDESDAIVNEKIPAVRSKRHKQCFCDD-----------GKTIDSSSLSHQERS 1322
+ E D+++ E + SK D+ K ID + +E+
Sbjct: 327 VDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQR 386
Query: 1323 RESLSVHQTLSAILQDIEEKQEYLLEFEIRNPE-------DAEQYIEKMLKIKKIMDNVL 1375
+E+ + + +EK Y F+ + + E E+ L+ KKI +
Sbjct: 387 KENEPEAEKTHLFAK--QEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCS 444
Query: 1376 AKQKAERDDL--AKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCR 1433
+ D+ K+Y VS E + G ++ +L N +++ + +K+ K + +I N
Sbjct: 445 VIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLT 504
Query: 1434 NVTSLPCLSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWN 1493
T L C K ++ TSL +L H +G S + E Q T
Sbjct: 505 VNTGLDC--SEKTREEGNFRKSFSPKDDTSL-HLFHISTGKSPKHSCGLSEKQ---STPL 558
Query: 1494 YSQNTNICLN 1503
++T CL+
Sbjct: 559 KQEHTKTCLS 568
Score = 104 bits (260), Expect = 7e-22
Identities = 62/174 (35%), Positives = 92/174 (52%), Gaps = 11/174 (6%)
Query: 460 RKNEQFSGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPS 519
+K S ++K KVNK RN GE ++ AA+ D V I G NVN
Sbjct: 164 QKKTPSSSSRQKDKVNK--------RNERGETPLHMAAIRGDVKQVKELISLGANVNVKD 215
Query: 520 YAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579
+AGWT LHEA G+Y A L+ GADVN +GL TPLHD+ +GH + +LLL +G
Sbjct: 216 FAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGG 275
Query: 580 DPLFRNDDGKCALDEAKDLCMKRLLERYIP---KHQKCLTSAQRSSIDPLDIED 630
+P N G+ +D A+ ++ LL+R +P + S + S++P +++
Sbjct: 276 NPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDE 329
>gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens]
Length = 777
Score = 105 bits (263), Expect = 3e-22
Identities = 62/162 (38%), Positives = 88/162 (54%), Gaps = 9/162 (5%)
Query: 1118 NMSKELANISK------LSQREKKEISHKPGMKAGRIN---KRNARGESQLHLAVRRGNL 1168
NMS E ++S LS + + P N KRN RGE+ LH+A +G++
Sbjct: 382 NMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDI 441
Query: 1169 PLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDA 1228
P V+ L+++G+D N+ D+AGWTPLHEA N G + ++ LL+ A VN PLHDA
Sbjct: 442 PSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDA 501
Query: 1229 VANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELL 1270
N H+ ++LL GA+ N + +D DDE MK LL
Sbjct: 502 AKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLL 543
Score = 76.3 bits (186), Expect = 3e-13
Identities = 46/121 (38%), Positives = 62/121 (51%)
Query: 484 RRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLK 543
+RN GE L++ A++ D V + ++ G + N +AGWT LHEA G + LL+
Sbjct: 423 KRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQ 482
Query: 544 GGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCMKRL 603
A VN G +PLHDA NGH + +LLL GA N G +D D MK L
Sbjct: 483 HKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSL 542
Query: 604 L 604
L
Sbjct: 543 L 543
>gi|188219549 ankyrin repeat domain 32 [Homo sapiens]
Length = 1058
Score = 91.7 bits (226), Expect = 6e-18
Identities = 57/169 (33%), Positives = 95/169 (56%), Gaps = 9/169 (5%)
Query: 1118 NMSKELANISKLSQREKKEISHKPG-----MKAGRINKRNARGESQLHLAVRRGNLP-LV 1171
N++K +++ KL ++ + E+S +K +K N +GE+ LH A + L+
Sbjct: 765 NLAKCSSSLKKLKKKSEGELSCSKENCPSVVKKMNFHKTNLKGETALHRACINNQVEKLI 824
Query: 1172 KALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVN-CENIDGILPLHDAVA 1230
L G D+N+ DNAGWTPLHEA N G+ + E+L+ +V+ +DG+ PLHDA++
Sbjct: 825 LLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHDALS 884
Query: 1231 NNHLKAAEILLQNGANP--NQKDQKQKSALDEADDEKMKELLRSYGAIE 1277
N H++ ++LLQ+G Q++ K + LD ++KE L + IE
Sbjct: 885 NGHVEIGKLLLQHGGPVLLQQRNAKGELPLDYVVSPQIKEELFAITKIE 933
Score = 61.2 bits (147), Expect = 9e-09
Identities = 41/124 (33%), Positives = 67/124 (54%), Gaps = 7/124 (5%)
Query: 474 VNKISLHSINRRNIFGENLVYKAALHDDAD-LVHHCIKKGGNVNQPSYAGWTALHEASVG 532
V K++ H + N+ GE +++A +++ + L+ G ++N AGWT LHEA
Sbjct: 795 VKKMNFH---KTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNY 851
Query: 533 GFYRTASELLKGGADVNIKGLYQ-ITPLHDAVMNGHYKVAELLLLNGADPLF--RNDDGK 589
G E+L+ +V++ +TPLHDA+ NGH ++ +LLL +G L RN G+
Sbjct: 852 GNTVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGE 911
Query: 590 CALD 593
LD
Sbjct: 912 LPLD 915
>gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens]
Length = 1378
Score = 90.1 bits (222), Expect = 2e-17
Identities = 77/261 (29%), Positives = 119/261 (45%), Gaps = 47/261 (18%)
Query: 1007 QNSLAC----MRTLLTHEASKLTNHVELFKKPQDYIPRAPTFLMNQTDTHIVE-KMAKNC 1061
Q +L+C R L + + + V+L +PQ+ AP +T+T + E +A++
Sbjct: 415 QKALSCAQQAQRPQLQRQVLQHLHTVQLRLQPQE----AP-----ETETRLRELSVAEDE 465
Query: 1062 DTERNYIDRDQKIIYSNEPLSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSK 1121
D E E + A S+ +E +VE TD ++
Sbjct: 466 DEEEEA-----------EEAAATAESEALEAGEVELSE------------GEDDTDGLTP 502
Query: 1122 ELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADV 1181
+L +L H K + N+RN GE+ LH A G L V+ L+ G +
Sbjct: 503 QLEEDEELQ-------GHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPL 555
Query: 1182 NLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVN---CENIDGILPLHDAVANNHLKAAE 1238
N D GWTPLHEA N G ++I+ LL GA V+ + +GI PLHDA+ H + AE
Sbjct: 556 NPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAE 615
Query: 1239 ILLQNGANPNQKDQKQKSALD 1259
+LL+ GA+ + +K S L+
Sbjct: 616 LLLERGASVTLRTRKGLSPLE 636
Score = 79.7 bits (195), Expect = 2e-14
Identities = 51/139 (36%), Positives = 70/139 (50%), Gaps = 8/139 (5%)
Query: 458 QIRKNEQFSGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQ 517
Q+ ++E+ G + K +K NRRN GE L+++A + V +++G +N
Sbjct: 503 QLEEDEELQGHLGRRKGSKW-----NRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNP 557
Query: 518 PSYAGWTALHEASVGGFYRTASELLKGGA---DVNIKGLYQITPLHDAVMNGHYKVAELL 574
Y GWT LHEA G LL GA D +G ITPLHDA+ GH++VAELL
Sbjct: 558 RDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELL 617
Query: 575 LLNGADPLFRNDDGKCALD 593
L GA R G L+
Sbjct: 618 LERGASVTLRTRKGLSPLE 636
>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
sapiens]
Length = 226
Score = 86.3 bits (212), Expect = 3e-16
Identities = 49/130 (37%), Positives = 74/130 (56%), Gaps = 3/130 (2%)
Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
LH A G+ +V+ L++ G VN D+AGW+PLH A++ G +I+ LL GA+VN N
Sbjct: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103
Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA---DDEKMKELLRSYGA 1275
+G PLH A + N + A +LL+ GANP+ KD + +A+ A + KM +L Y A
Sbjct: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKA 163
Query: 1276 IETVNRDESD 1285
+ E +
Sbjct: 164 STNIQDTEGN 173
Score = 71.6 bits (174), Expect = 7e-12
Identities = 51/140 (36%), Positives = 75/140 (53%), Gaps = 4/140 (2%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
+N ++ G S LH+A G +VKAL+ GA VN + G TPLH A+++ +I V L
Sbjct: 66 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMK 1267
L+ GA + ++ +H A A +LK ILL A+ N +D + + L A DE+
Sbjct: 126 LEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV 185
Query: 1268 E---LLRSYGA-IETVNRDE 1283
E LL S GA I N++E
Sbjct: 186 EEAKLLVSQGASIYIENKEE 205
Score = 58.5 bits (140), Expect = 6e-08
Identities = 33/118 (27%), Positives = 63/118 (53%)
Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
K ++N N G + LH A + + L+E GA+ + D+ T +H A+ +G++ +
Sbjct: 95 KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKM 154
Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
I LL A N ++ +G PLH A ++ A++L+ GA+ +++++K+ L A
Sbjct: 155 IHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
Score = 55.1 bits (131), Expect = 6e-07
Identities = 37/121 (30%), Positives = 58/121 (47%), Gaps = 1/121 (0%)
Query: 462 NEQFSGKKEKMKVNKISLHSI-NRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSY 520
N +SGK E++K + ++ S+ R + ++ A ++V ++ G VN
Sbjct: 12 NLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDD 71
Query: 521 AGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGAD 580
AGW+ LH A+ G LL GA VN TPLH A +++A +LL GA+
Sbjct: 72 AGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131
Query: 581 P 581
P
Sbjct: 132 P 132
Score = 50.8 bits (120), Expect = 1e-05
Identities = 34/116 (29%), Positives = 57/116 (49%)
Query: 482 INRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASEL 541
+N ++ G + ++ AA ++V + KG VN + G T LH A+ + A L
Sbjct: 66 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
Query: 542 LKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKD 597
L+GGA+ + K Y+ T +H A G+ K+ +LL A ++ +G L A D
Sbjct: 126 LEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACD 181
Score = 42.7 bits (99), Expect = 0.003
Identities = 39/143 (27%), Positives = 63/143 (44%), Gaps = 3/143 (2%)
Query: 466 SGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTA 525
+G+ E +K +N N G ++ AA + ++ ++ G N + + TA
Sbjct: 83 AGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATA 142
Query: 526 LHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRN 585
+H A+ G + LL A NI+ TPLH A + A+LL+ GA N
Sbjct: 143 MHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIEN 202
Query: 586 DDGKCALDEAK---DLCMKRLLE 605
+ K L AK L +KR++E
Sbjct: 203 KEEKTPLQVAKGGLGLILKRMVE 225
Score = 31.6 bits (70), Expect = 7.6
Identities = 23/65 (35%), Positives = 29/65 (44%)
Query: 524 TALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLF 583
TALH A G LL+ G VN K +PLH A G ++ + LL GA
Sbjct: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
Query: 584 RNDDG 588
N +G
Sbjct: 102 VNQNG 106
>gi|28605137 proteasome 26S non-ATPase subunit 10 isform 2 [Homo
sapiens]
Length = 151
Score = 84.7 bits (208), Expect = 8e-16
Identities = 43/103 (41%), Positives = 64/103 (62%)
Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
LH A G+ +V+ L++ G VN D+AGW+PLH A++ G +I+ LL GA+VN N
Sbjct: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103
Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
+G PLH A + N + A +LL+ GANP+ KD + +A+ A
Sbjct: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRA 146
Score = 55.1 bits (131), Expect = 6e-07
Identities = 37/121 (30%), Positives = 58/121 (47%), Gaps = 1/121 (0%)
Query: 462 NEQFSGKKEKMKVNKISLHSI-NRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSY 520
N +SGK E++K + ++ S+ R + ++ A ++V ++ G VN
Sbjct: 12 NLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDD 71
Query: 521 AGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGAD 580
AGW+ LH A+ G LL GA VN TPLH A +++A +LL GA+
Sbjct: 72 AGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131
Query: 581 P 581
P
Sbjct: 132 P 132
Score = 53.5 bits (127), Expect = 2e-06
Identities = 30/85 (35%), Positives = 47/85 (55%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
+N ++ G S LH+A G +VKAL+ GA VN + G TPLH A+++ +I V L
Sbjct: 66 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
Query: 1208 LKAGAKVNCENIDGILPLHDAVANN 1232
L+ GA + ++ +H A A +
Sbjct: 126 LEGGANPDAKDHYEATAMHRAAAKD 150
Score = 39.7 bits (91), Expect = 0.028
Identities = 25/81 (30%), Positives = 42/81 (51%)
Query: 482 INRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASEL 541
+N ++ G + ++ AA ++V + KG VN + G T LH A+ + A L
Sbjct: 66 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
Query: 542 LKGGADVNIKGLYQITPLHDA 562
L+GGA+ + K Y+ T +H A
Sbjct: 126 LEGGANPDAKDHYEATAMHRA 146
Score = 31.6 bits (70), Expect = 7.6
Identities = 23/65 (35%), Positives = 29/65 (44%)
Query: 524 TALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLF 583
TALH A G LL+ G VN K +PLH A G ++ + LL GA
Sbjct: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
Query: 584 RNDDG 588
N +G
Sbjct: 102 VNQNG 106
>gi|183396783 BCL-6 interacting corepressor isoform a [Homo sapiens]
Length = 1721
Score = 84.7 bits (208), Expect = 8e-16
Identities = 53/144 (36%), Positives = 76/144 (52%), Gaps = 2/144 (1%)
Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESG-ADVNLNDNAGWTPLHEASNEGSID 1202
+A R+ GE+ L A R G +V +E+ DVN DNAG+ LHEA G ++
Sbjct: 1418 EARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLN 1477
Query: 1203 IIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEAD 1262
I+ LL+ GA VNC DG PLHDAV N+HL+ +LL GA+P ++ +
Sbjct: 1478 IVRHLLEYGADVNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTH 1537
Query: 1263 DEKMKELLRSYGAIETVNRDESDA 1286
E M++ L Y + R++ DA
Sbjct: 1538 SELMEKFLTDY-LNDLQGRNDDDA 1560
Score = 72.4 bits (176), Expect = 4e-12
Identities = 44/121 (36%), Positives = 62/121 (51%), Gaps = 1/121 (0%)
Query: 489 GENLVYKAALHDDADLVHHCIK-KGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGAD 547
GE L+ +AA ++V +C++ K +VN AG+ ALHEA G+ LL+ GAD
Sbjct: 1429 GETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGAD 1488
Query: 548 VNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCMKRLLERY 607
VN PLHDAV N H ++ LLL GADP G+ + M++ L Y
Sbjct: 1489 VNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFLTDY 1548
Query: 608 I 608
+
Sbjct: 1549 L 1549
>gi|183396787 BCL-6 interacting corepressor isoform c [Homo sapiens]
Length = 1755
Score = 84.7 bits (208), Expect = 8e-16
Identities = 53/144 (36%), Positives = 76/144 (52%), Gaps = 2/144 (1%)
Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESG-ADVNLNDNAGWTPLHEASNEGSID 1202
+A R+ GE+ L A R G +V +E+ DVN DNAG+ LHEA G ++
Sbjct: 1452 EARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLN 1511
Query: 1203 IIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEAD 1262
I+ LL+ GA VNC DG PLHDAV N+HL+ +LL GA+P ++ +
Sbjct: 1512 IVRHLLEYGADVNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTH 1571
Query: 1263 DEKMKELLRSYGAIETVNRDESDA 1286
E M++ L Y + R++ DA
Sbjct: 1572 SELMEKFLTDY-LNDLQGRNDDDA 1594
Score = 72.4 bits (176), Expect = 4e-12
Identities = 44/121 (36%), Positives = 62/121 (51%), Gaps = 1/121 (0%)
Query: 489 GENLVYKAALHDDADLVHHCIK-KGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGAD 547
GE L+ +AA ++V +C++ K +VN AG+ ALHEA G+ LL+ GAD
Sbjct: 1463 GETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGAD 1522
Query: 548 VNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCMKRLLERY 607
VN PLHDAV N H ++ LLL GADP G+ + M++ L Y
Sbjct: 1523 VNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFLTDY 1582
Query: 608 I 608
+
Sbjct: 1583 L 1583
>gi|183396785 BCL-6 interacting corepressor isoform b [Homo sapiens]
Length = 1703
Score = 84.7 bits (208), Expect = 8e-16
Identities = 53/144 (36%), Positives = 76/144 (52%), Gaps = 2/144 (1%)
Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESG-ADVNLNDNAGWTPLHEASNEGSID 1202
+A R+ GE+ L A R G +V +E+ DVN DNAG+ LHEA G ++
Sbjct: 1400 EARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLN 1459
Query: 1203 IIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEAD 1262
I+ LL+ GA VNC DG PLHDAV N+HL+ +LL GA+P ++ +
Sbjct: 1460 IVRHLLEYGADVNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTH 1519
Query: 1263 DEKMKELLRSYGAIETVNRDESDA 1286
E M++ L Y + R++ DA
Sbjct: 1520 SELMEKFLTDY-LNDLQGRNDDDA 1542
Score = 72.4 bits (176), Expect = 4e-12
Identities = 44/121 (36%), Positives = 62/121 (51%), Gaps = 1/121 (0%)
Query: 489 GENLVYKAALHDDADLVHHCIK-KGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGAD 547
GE L+ +AA ++V +C++ K +VN AG+ ALHEA G+ LL+ GAD
Sbjct: 1411 GETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGAD 1470
Query: 548 VNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCMKRLLERY 607
VN PLHDAV N H ++ LLL GADP G+ + M++ L Y
Sbjct: 1471 VNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFLTDY 1530
Query: 608 I 608
+
Sbjct: 1531 L 1531
>gi|21071037 BCL-6 interacting corepressor isoform a [Homo sapiens]
Length = 1721
Score = 84.7 bits (208), Expect = 8e-16
Identities = 53/144 (36%), Positives = 76/144 (52%), Gaps = 2/144 (1%)
Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESG-ADVNLNDNAGWTPLHEASNEGSID 1202
+A R+ GE+ L A R G +V +E+ DVN DNAG+ LHEA G ++
Sbjct: 1418 EARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLN 1477
Query: 1203 IIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEAD 1262
I+ LL+ GA VNC DG PLHDAV N+HL+ +LL GA+P ++ +
Sbjct: 1478 IVRHLLEYGADVNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTH 1537
Query: 1263 DEKMKELLRSYGAIETVNRDESDA 1286
E M++ L Y + R++ DA
Sbjct: 1538 SELMEKFLTDY-LNDLQGRNDDDA 1560
Score = 72.4 bits (176), Expect = 4e-12
Identities = 44/121 (36%), Positives = 62/121 (51%), Gaps = 1/121 (0%)
Query: 489 GENLVYKAALHDDADLVHHCIK-KGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGAD 547
GE L+ +AA ++V +C++ K +VN AG+ ALHEA G+ LL+ GAD
Sbjct: 1429 GETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGAD 1488
Query: 548 VNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCMKRLLERY 607
VN PLHDAV N H ++ LLL GADP G+ + M++ L Y
Sbjct: 1489 VNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFLTDY 1548
Query: 608 I 608
+
Sbjct: 1549 L 1549
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 82.4 bits (202), Expect = 4e-15
Identities = 46/125 (36%), Positives = 69/125 (55%), Gaps = 2/125 (1%)
Query: 1148 INKRNARGESQ--LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIV 1205
IN R+ +G + LHLA NL + + L+E GADVN D G PLH A++ G +DI
Sbjct: 828 INCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAA 887
Query: 1206 ELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEK 1265
L+K VN + PLH+A + +LL +GA+P K+Q+ ++ LD A +
Sbjct: 888 LLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADD 947
Query: 1266 MKELL 1270
++ LL
Sbjct: 948 IRALL 952
Score = 82.0 bits (201), Expect = 5e-15
Identities = 53/167 (31%), Positives = 81/167 (48%), Gaps = 4/167 (2%)
Query: 1145 AGRINKRNARGE--SQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSID 1202
A +N ++ G S LH A G +V+ L++ GA+V+ D+ G PLH A + G +
Sbjct: 204 AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAE 263
Query: 1203 IIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEAD 1262
++ LL GA N + PLH+A + +LLQ+GA+PN ++ KSALD AD
Sbjct: 264 VVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLAD 323
Query: 1263 DEKMKELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGK 1309
L Y E + S EK+ A+ + + C DG+
Sbjct: 324 PSAKAVLTGEYKKDELLEAARSGN--EEKLMALLTPLNVNCHASDGR 368
Score = 79.0 bits (193), Expect = 4e-14
Identities = 42/119 (35%), Positives = 67/119 (56%)
Query: 1152 NARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAG 1211
+ R + LHLA + +V+ L++ GADV+ D G PLH A + G ++ LLK G
Sbjct: 366 DGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHG 425
Query: 1212 AKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELL 1270
A VN ++ PLH+A + N ++ +LL +GA+P + KSA+D A +++E L
Sbjct: 426 ACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERL 484
Score = 77.8 bits (190), Expect = 9e-14
Identities = 42/122 (34%), Positives = 68/122 (55%), Gaps = 2/122 (1%)
Query: 478 SLHSINRRNIFGENL--VYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFY 535
S ++N R++ G + ++ AA ++ +V + + G +V+ G LH A G Y
Sbjct: 671 SSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHY 730
Query: 536 RTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
A L++ GA VN+ L++ TPLH+A G Y++ +LLL +GADP +N DG LD
Sbjct: 731 EVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLV 790
Query: 596 KD 597
K+
Sbjct: 791 KE 792
Score = 74.7 bits (182), Expect = 8e-13
Identities = 52/180 (28%), Positives = 89/180 (49%), Gaps = 12/180 (6%)
Query: 1105 SETIHNIDSHST----DNMSKELANISKLSQREKKEISHKPGMKAGRINKRNARGE--SQ 1158
+E + I S ST ++ L SK E + K + +N R+ G +
Sbjct: 632 NEAVQQILSESTPIRTSDVDYRLLEASKAGDLE----TVKQLCSSQNVNCRDLEGRHSTP 687
Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
LH A + +V+ L+ GADV+ D G PLH A + G ++ L++ GA VN +
Sbjct: 688 LHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVAD 747
Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALD--EADDEKMKELLRSYGAI 1276
+ PLH+A A + ++LL++GA+P +K++ + LD + D +++LLR A+
Sbjct: 748 LWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAAL 807
Score = 71.6 bits (174), Expect = 7e-12
Identities = 50/148 (33%), Positives = 72/148 (48%), Gaps = 4/148 (2%)
Query: 481 SINRRNIFGENL--VYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTA 538
++N +++ G ++ AA D+V H ++ G NV+ G LH A G
Sbjct: 206 NVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVV 265
Query: 539 SELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDL 598
S LL GAD N + + TPLH+A + G V +LL +GADP RN DGK ALD A
Sbjct: 266 SLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPS 325
Query: 599 CMKRLLERYIPKHQKCLTSAQRSSIDPL 626
L Y K + L +A+ + + L
Sbjct: 326 AKAVLTGEY--KKDELLEAARSGNEEKL 351
Score = 68.2 bits (165), Expect = 7e-11
Identities = 54/211 (25%), Positives = 93/211 (44%), Gaps = 9/211 (4%)
Query: 466 SGKKEKMKVN----KISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYA 521
SG +EK+ ++ H+ + R ++ AA ++ +V ++ G +V+
Sbjct: 345 SGNEEKLMALLTPLNVNCHASDGRK---STPLHLAAGYNRVRIVQLLLQHGADVHAKDKG 401
Query: 522 GWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
G LH A G Y LLK GA VN L+Q TPLH+A +V LLL +GADP
Sbjct: 402 GLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADP 461
Query: 582 LFRNDDGKCALDEAKDLCMKRLLERYIPKHQ--KCLTSAQRSSIDPLDIEDVYQHKKPKF 639
N GK A+D A ++ L H + A + + ++ K+P+
Sbjct: 462 TLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQS 521
Query: 640 SSKSHIWHVYNENSNRQKLEHVKVNKGSKAS 670
+ V + + R+++ + + KG+ +
Sbjct: 522 HETALHCAVASLHPKRKQVTELLLRKGANVN 552
Score = 65.5 bits (158), Expect = 5e-10
Identities = 41/131 (31%), Positives = 68/131 (51%), Gaps = 2/131 (1%)
Query: 481 SINRRNIFGENL--VYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTA 538
+IN R+ G N ++ AA +++ ++ + ++ G +VN G LH A+ G A
Sbjct: 827 NINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIA 886
Query: 539 SELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDL 598
+ L+K VN + TPLH+A G ++ LLL +GADP +N +G+ LD A
Sbjct: 887 ALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATAD 946
Query: 599 CMKRLLERYIP 609
++ LL +P
Sbjct: 947 DIRALLIDAMP 957
Score = 63.5 bits (153), Expect = 2e-09
Identities = 55/195 (28%), Positives = 92/195 (47%), Gaps = 13/195 (6%)
Query: 1156 ESQLHLAVRRGNLPLVKALIES-GADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
+ +L A R GN + AL+ + + +D TPLH A+ + I+ LL+ GA V
Sbjct: 336 KDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADV 395
Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKE---LLR 1271
+ ++ G++PLH+A + H + E+LL++GA N D Q + L EA + E LL
Sbjct: 396 HAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLL 455
Query: 1272 SYGAIET-VNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQERSRESLSVHQ 1330
S+GA T VN A+ P +R + + SL R + V +
Sbjct: 456 SHGADPTLVNCHGKSAVDMAPTPELRERLTYE--------FKGHSLLQAAREADLAKVKK 507
Query: 1331 TLSAILQDIEEKQEY 1345
TL+ + + ++ Q +
Sbjct: 508 TLALEIINFKQPQSH 522
Score = 52.0 bits (123), Expect = 5e-06
Identities = 50/197 (25%), Positives = 86/197 (43%), Gaps = 36/197 (18%)
Query: 1110 NIDSHSTDNMSKELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLP 1169
N++ + D M+ L ++ + + E+ HK G K +N + G++ LH A G+L
Sbjct: 550 NVNEKNKDFMTP-LHVAAERAHNDVMEVLHKHGAK---MNALDTLGQTALHRAALAGHLQ 605
Query: 1170 LVKALIESGADVNLNDNAGWTP--------------------------LHEASNEGSIDI 1203
+ L+ G+D ++ G+T L EAS G ++
Sbjct: 606 TCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLET 665
Query: 1204 IVELLKAGAKVNCENIDG--ILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
+ +L + VNC +++G PLH A N + E LL +GA+ + KD+ L A
Sbjct: 666 VKQLC-SSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNA 724
Query: 1262 ---DDEKMKELLRSYGA 1275
++ ELL +GA
Sbjct: 725 CSYGHYEVAELLVRHGA 741
Score = 50.8 bits (120), Expect = 1e-05
Identities = 32/96 (33%), Positives = 48/96 (50%), Gaps = 3/96 (3%)
Query: 1156 ESQLHLAVRR---GNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGA 1212
E+ LH AV + + L+ GA+VN + TPLH A+ D++ L K GA
Sbjct: 523 ETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGA 582
Query: 1213 KVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
K+N + G LH A HL+ +LL G++P+
Sbjct: 583 KMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPS 618
Score = 43.5 bits (101), Expect = 0.002
Identities = 26/73 (35%), Positives = 35/73 (47%)
Query: 509 IKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHY 568
++KG NVN+ + T LH A+ L K GA +N T LH A + GH
Sbjct: 545 LRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHL 604
Query: 569 KVAELLLLNGADP 581
+ LLL G+DP
Sbjct: 605 QTCRLLLSYGSDP 617
Score = 42.0 bits (97), Expect = 0.006
Identities = 45/188 (23%), Positives = 73/188 (38%), Gaps = 60/188 (31%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
++ ++ G LH A G+ + + L++ GA VN D +TPLHEA+++ +++ L
Sbjct: 395 VHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLL 454
Query: 1208 LKAGAK---VNCENIDGI------------------------------------------ 1222
L GA VNC +
Sbjct: 455 LSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEII 514
Query: 1223 ---------LPLHDAVANNHLK---AAEILLQNGANPNQKDQKQKSALDEADD---EKMK 1267
LH AVA+ H K E+LL+ GAN N+K++ + L A + +
Sbjct: 515 NFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVM 574
Query: 1268 ELLRSYGA 1275
E+L +GA
Sbjct: 575 EVLHKHGA 582
Score = 41.2 bits (95), Expect = 0.010
Identities = 23/89 (25%), Positives = 45/89 (50%)
Query: 1133 EKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPL 1192
++K+++ K +N++N + LH+A R + +++ L + GA +N D G T L
Sbjct: 536 KRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTAL 595
Query: 1193 HEASNEGSIDIIVELLKAGAKVNCENIDG 1221
H A+ G + LL G+ + ++ G
Sbjct: 596 HRAALAGHLQTCRLLLSYGSDPSIISLQG 624
Score = 39.3 bits (90), Expect = 0.036
Identities = 27/72 (37%), Positives = 37/72 (51%), Gaps = 3/72 (4%)
Query: 1207 LLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDE---ADD 1263
LL+ GA VN +N D + PLH A H E+L ++GA N D ++AL A
Sbjct: 544 LLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGH 603
Query: 1264 EKMKELLRSYGA 1275
+ LL SYG+
Sbjct: 604 LQTCRLLLSYGS 615
Score = 37.0 bits (84), Expect = 0.18
Identities = 28/94 (29%), Positives = 43/94 (45%), Gaps = 9/94 (9%)
Query: 486 NIFGENLVYKAALHDDADLVHHCI-----KKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
N+ +N + LH A+ H+ + K G +N G TALH A++ G +T
Sbjct: 550 NVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRL 609
Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELL 574
LL G+D +I L T A G+ V ++L
Sbjct: 610 LLSYGSDPSIISLQGFT----AAQMGNEAVQQIL 639
Score = 33.9 bits (76), Expect = 1.5
Identities = 32/85 (37%), Positives = 43/85 (50%), Gaps = 4/85 (4%)
Query: 514 NVNQPSYAGWTALH--EASVGGFYRTASELL-KGGADVNIKGLYQITPLHDAVMNGHYKV 570
N QP + TALH AS+ + +ELL + GA+VN K +TPLH A H V
Sbjct: 515 NFKQPQ-SHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDV 573
Query: 571 AELLLLNGADPLFRNDDGKCALDEA 595
E+L +GA + G+ AL A
Sbjct: 574 MEVLHKHGAKMNALDTLGQTALHRA 598
Score = 31.6 bits (70), Expect = 7.6
Identities = 17/69 (24%), Positives = 32/69 (46%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
+N + + LH A ++G L L+ GAD + + G TPL A+ + ++++
Sbjct: 896 VNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDA 955
Query: 1208 LKAGAKVNC 1216
+ A C
Sbjct: 956 MPPEALPTC 964
>gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]
Length = 1202
Score = 82.0 bits (201), Expect = 5e-15
Identities = 44/114 (38%), Positives = 72/114 (63%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
+N ++A G S LH A G+L L+ L+E+ A V++ D+ G PLH A+ +G ++ + L
Sbjct: 42 VNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLL 101
Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
L+A A VN ++DG +PLH A H + +E+LLQ+ +NP ++ +K+ LD A
Sbjct: 102 LRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLA 155
Score = 57.0 bits (136), Expect = 2e-07
Identities = 47/204 (23%), Positives = 92/204 (45%), Gaps = 18/204 (8%)
Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
++N ++ G + ++ AAL +L+ ++ V+ G LH A+ G
Sbjct: 41 NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRL 100
Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM 600
LL+ A VN L PLH A GHY+V+E+LL + ++P N K LD A +
Sbjct: 101 LLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGR 160
Query: 601 KRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKKPKFSSKSHIWHVYNENSNRQKLEH 660
++ + + H C+ + + DP D P +++ H+ +N +R+ +
Sbjct: 161 LKVAQLLLNSH-LCVALLEGEAKDPCD---------PNYTTPLHL---AAKNGHREVIRQ 207
Query: 661 -----VKVNKGSKASLFINKEDVY 679
+++N+ +K +++ +Y
Sbjct: 208 LLRAGIEINRQTKTGTALHEAALY 231
Score = 48.1 bits (113), Expect = 8e-05
Identities = 38/140 (27%), Positives = 65/140 (46%), Gaps = 16/140 (11%)
Query: 1152 NARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAG--------WTPLHEASNEGSIDI 1203
N ++ L LA G L + + L+ S V L + TPLH A+ G ++
Sbjct: 145 NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 204
Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEAD- 1262
I +LL+AG ++N + G LH+A + +LL+ G + N ++ ++ALD +
Sbjct: 205 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQ 263
Query: 1263 ------DEKMKELLRSYGAI 1276
++K+LLR I
Sbjct: 264 FTTSQASREIKQLLREASGI 283
Score = 42.0 bits (97), Expect = 0.006
Identities = 23/67 (34%), Positives = 38/67 (56%), Gaps = 1/67 (1%)
Query: 493 VYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKG 552
++ AA + +++ ++ G +N+ + G TALHEA++ G LL+GG DVNI+
Sbjct: 193 LHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRN 251
Query: 553 LYQITPL 559
Y T L
Sbjct: 252 TYNQTAL 258
Score = 41.2 bits (95), Expect = 0.010
Identities = 48/171 (28%), Positives = 77/171 (45%), Gaps = 19/171 (11%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI---- 1203
+N + G+ LHLA + G+ + + L++ ++ L + A TPL A G + +
Sbjct: 108 VNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLL 167
Query: 1204 -----IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSAL 1258
V LL+ AK C+ + PLH A N H + LL+ G N + K +AL
Sbjct: 168 LNSHLCVALLEGEAKDPCDP-NYTTPLHLAAKNGHREVIRQLLRAGIEIN-RQTKTGTAL 225
Query: 1259 DEADDEKMKELLRSY--GAIE-----TVNRDESDAIVNEKIPAVRSKRHKQ 1302
EA E++R G ++ T N+ D IVN+ + S+ KQ
Sbjct: 226 HEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALD-IVNQFTTSQASREIKQ 275
Score = 40.8 bits (94), Expect = 0.013
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 3/76 (3%)
Query: 518 PSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLN 577
P+Y T LH A+ G +LL+ G ++N + T LH+A + G +V LLL
Sbjct: 187 PNYT--TPLHLAAKNGHREVIRQLLRAGIEIN-RQTKTGTALHEAALYGKTEVVRLLLEG 243
Query: 578 GADPLFRNDDGKCALD 593
G D RN + ALD
Sbjct: 244 GVDVNIRNTYNQTALD 259
Score = 33.9 bits (76), Expect = 1.5
Identities = 26/102 (25%), Positives = 47/102 (46%), Gaps = 5/102 (4%)
Query: 1143 MKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPL----HEASNE 1198
++AG R + + LH A G +V+ L+E G DVN+ + T L +++
Sbjct: 209 LRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQ 268
Query: 1199 GSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEIL 1240
S +I L +A + + LHD A N ++A +++
Sbjct: 269 ASREIKQLLREASGILKVRALKDFWNLHDPTALN-VRAGDVI 309
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 81.6 bits (200), Expect = 6e-15
Identities = 45/122 (36%), Positives = 69/122 (56%), Gaps = 2/122 (1%)
Query: 478 SLHSINRRNIFGENL--VYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFY 535
++ S+N R+I G ++ AA ++ +V + ++ G +V+ G LH A G Y
Sbjct: 513 TVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHY 572
Query: 536 RTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
A L+K GA VN+ L++ TPLH+A G Y++ +LLL +GADP +N DG LD
Sbjct: 573 EVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV 632
Query: 596 KD 597
KD
Sbjct: 633 KD 634
Score = 79.0 bits (193), Expect = 4e-14
Identities = 43/125 (34%), Positives = 68/125 (54%), Gaps = 2/125 (1%)
Query: 1148 INKRNARGE--SQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIV 1205
+N R+ +G + LHLA NL + + L++ GADVN D G PLH A++ G +D+
Sbjct: 670 VNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAA 729
Query: 1206 ELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEK 1265
L+K A VN + PLH+A + +LL +GA+P K+Q+ ++ LD +
Sbjct: 730 LLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADD 789
Query: 1266 MKELL 1270
+ LL
Sbjct: 790 VSALL 794
Score = 78.2 bits (191), Expect = 7e-14
Identities = 49/165 (29%), Positives = 79/165 (47%), Gaps = 4/165 (2%)
Query: 1147 RINKRNARGESQ--LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDII 1204
++N R+ G LH A G +V+ L+++GA+V D+ G PLH A + G +++
Sbjct: 48 KVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVV 107
Query: 1205 VELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDE 1264
LL+ GA N + PLH+A + +LLQ+GA P ++ ++ALD AD
Sbjct: 108 NLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPS 167
Query: 1265 KMKELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGK 1309
L Y E + S EK+ A+ + + C DG+
Sbjct: 168 AKAVLTGEYKKDELLESARSGN--EEKMMALLTPLNVNCHASDGR 210
Score = 76.6 bits (187), Expect = 2e-13
Identities = 44/133 (33%), Positives = 73/133 (54%), Gaps = 4/133 (3%)
Query: 1148 INKRNARGESQ--LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIV 1205
+N R+ G LH A + +V+ L++ GADV+ D G PLH A + G ++
Sbjct: 517 VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAE 576
Query: 1206 ELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALD--EADD 1263
L+K GA VN ++ PLH+A A + ++LLQ+GA+P +K++ + LD + D
Sbjct: 577 LLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGD 636
Query: 1264 EKMKELLRSYGAI 1276
+++LLR A+
Sbjct: 637 TDIQDLLRGDAAL 649
Score = 76.3 bits (186), Expect = 3e-13
Identities = 41/119 (34%), Positives = 65/119 (54%)
Query: 1152 NARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAG 1211
+ R + LHLA + +V+ L++ GADV+ D PLH A + G ++ L+K G
Sbjct: 208 DGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHG 267
Query: 1212 AKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELL 1270
A VN ++ PLH+A + N ++ +LL GA+P + KSA+D A ++KE L
Sbjct: 268 ACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERL 326
Score = 70.1 bits (170), Expect = 2e-11
Identities = 50/156 (32%), Positives = 75/156 (48%), Gaps = 5/156 (3%)
Query: 466 SGKKEKMKVNKISLHSINRRNIFGENL--VYKAALHDDADLVHHCIKKGGNVNQPSYAGW 523
+G E++K ++ +N R+ G ++ AA D+V + ++ G NV G
Sbjct: 34 NGDVERVK-RLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGL 92
Query: 524 TALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLF 583
LH A G + LL+ GAD N + + TPLH+A + G V +LL +GA+P
Sbjct: 93 IPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTI 152
Query: 584 RNDDGKCALDEAKDLCMKRLLERYIPKHQKCLTSAQ 619
RN DG+ ALD A L Y K + L SA+
Sbjct: 153 RNTDGRTALDLADPSAKAVLTGEY--KKDELLESAR 186
Score = 65.9 bits (159), Expect = 4e-10
Identities = 55/214 (25%), Positives = 98/214 (45%), Gaps = 10/214 (4%)
Query: 473 KVNKISL-HSINRRNIFGENL--VYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEA 529
+V K+S ++N R+ G + ++ AA +++ ++ + ++ G +VN G LH A
Sbjct: 660 RVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNA 719
Query: 530 SVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGK 589
+ G A+ L+K A VN + TPLH+A G ++ LLL +GADP +N +G+
Sbjct: 720 ASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQ 779
Query: 590 CALDEAKDLCMKRLLERYIPKHQKCLTSAQRSSI-----DPLDIEDVYQHKKPKFSSKSH 644
LD + LL +P L S + + P D SS S
Sbjct: 780 TPLDLVSADDVSALLTAAMP--PSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSA 837
Query: 645 IWHVYNENSNRQKLEHVKVNKGSKASLFINKEDV 678
+ N + + +L V + G++ + + K++V
Sbjct: 838 ASSLDNLSGSFSELSSVVSSSGTEGASSLEKKEV 871
Score = 63.2 bits (152), Expect = 2e-09
Identities = 49/162 (30%), Positives = 73/162 (45%), Gaps = 8/162 (4%)
Query: 466 SGKKEKMKVN----KISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYA 521
SG +EKM ++ H+ + R ++ AA ++ +V ++ G +V+
Sbjct: 187 SGNEEKMMALLTPLNVNCHASDGRK---STPLHLAAGYNRVKIVQLLLQHGADVHAKDKG 243
Query: 522 GWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
LH A G Y L+K GA VN L+Q TPLH+A +V LLL GADP
Sbjct: 244 DLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADP 303
Query: 582 LFRNDDGKCALDEAKDLCMKRLLERYIPKHQKCLTSAQRSSI 623
N K A+D A +K L Y K L +A+ + +
Sbjct: 304 TLLNCHNKSAIDLAPTPQLKERL-AYEFKGHSLLQAAREADV 344
Score = 59.3 bits (142), Expect = 3e-08
Identities = 45/139 (32%), Positives = 65/139 (46%), Gaps = 13/139 (9%)
Query: 1134 KKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLH 1193
+K++ + R+ G LH A G+ +V L+ GAD N DN +TPLH
Sbjct: 70 RKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLH 129
Query: 1194 EASNEGSIDIIVELLKAGAKVNCENIDG--ILPLHDAVANNHLKAAEILLQNGANPNQKD 1251
EA+ +G ID+ + LL+ GA+ N DG L L D A L +KD
Sbjct: 130 EAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVL----------TGEYKKD 179
Query: 1252 QKQKSALDEADDEKMKELL 1270
+ +SA ++EKM LL
Sbjct: 180 ELLESA-RSGNEEKMMALL 197
Score = 58.9 bits (141), Expect = 4e-08
Identities = 41/128 (32%), Positives = 68/128 (53%), Gaps = 4/128 (3%)
Query: 1156 ESQLHLAVRRGNLPLVKALIES-GADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
+ +L + R GN + AL+ + + +D TPLH A+ + I+ LL+ GA V
Sbjct: 178 KDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADV 237
Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKE---LLR 1271
+ ++ ++PLH+A + H + E+L+++GA N D Q + L EA + E LL
Sbjct: 238 HAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLL 297
Query: 1272 SYGAIETV 1279
SYGA T+
Sbjct: 298 SYGADPTL 305
Score = 50.8 bits (120), Expect = 1e-05
Identities = 32/102 (31%), Positives = 54/102 (52%), Gaps = 1/102 (0%)
Query: 1170 LVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAV 1229
+ + L+ GA++N TPLH AS + D++ ++K AKVN + G LH A
Sbjct: 382 ICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAA 441
Query: 1230 ANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELLR 1271
HL+ +LL G +PN + +AL + +E +++LL+
Sbjct: 442 YCGHLQTCRLLLSYGCDPNIISLQGFTAL-QMGNENVQQLLQ 482
Score = 50.1 bits (118), Expect = 2e-05
Identities = 49/200 (24%), Positives = 88/200 (44%), Gaps = 14/200 (7%)
Query: 1072 QKIIYSNEPLSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSKELANISKLSQ 1131
+++ Y + S++ ++ + T+++K HL E + N T + A S +
Sbjct: 324 ERLAYEFKGHSLLQAAREADVTRIKK----HLSLEMV-NFKHPQTHETALHCAAASPYPK 378
Query: 1132 REKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTP 1191
R K+I K IN++ + LH+A + + +V+ +++ A VN DN G T
Sbjct: 379 R--KQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTS 436
Query: 1192 LHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGAN--PNQ 1249
LH A+ G + LL G N ++ G L N + LLQ G + ++
Sbjct: 437 LHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN-----VQQLLQEGISLGNSE 491
Query: 1250 KDQKQKSALDEADDEKMKEL 1269
D++ A D E +K+L
Sbjct: 492 ADRQLLEAAKAGDVETVKKL 511
Score = 41.6 bits (96), Expect = 0.007
Identities = 30/97 (30%), Positives = 41/97 (42%)
Query: 509 IKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHY 568
++KG N+N+ + T LH AS ++K A VN T LH A GH
Sbjct: 387 LRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHL 446
Query: 569 KVAELLLLNGADPLFRNDDGKCALDEAKDLCMKRLLE 605
+ LLL G DP + G AL + + L E
Sbjct: 447 QTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQE 483
Score = 34.7 bits (78), Expect = 0.90
Identities = 25/72 (34%), Positives = 33/72 (45%), Gaps = 4/72 (5%)
Query: 503 DLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDA 562
D+V +K VN G T+LH A+ G +T LL G D NI L T A
Sbjct: 414 DVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFT----A 469
Query: 563 VMNGHYKVAELL 574
+ G+ V +LL
Sbjct: 470 LQMGNENVQQLL 481
Score = 31.2 bits (69), Expect = 9.9
Identities = 30/110 (27%), Positives = 49/110 (44%), Gaps = 4/110 (3%)
Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRT---ASELLKGG 545
G +L+ A D + H + N P TALH A+ + + LL+ G
Sbjct: 332 GHSLLQAAREADVTRIKKHLSLEMVNFKHPQ-THETALHCAAASPYPKRKQICELLLRKG 390
Query: 546 ADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
A++N K +TPLH A H V E+++ + A ++ G+ +L A
Sbjct: 391 ANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRA 440
Score = 31.2 bits (69), Expect = 9.9
Identities = 18/69 (26%), Positives = 30/69 (43%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
+N + + LH A ++G L L+ GAD L + G TPL S + ++
Sbjct: 738 VNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAA 797
Query: 1208 LKAGAKVNC 1216
+ A +C
Sbjct: 798 MPPSALPSC 806
>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
Length = 1050
Score = 80.5 bits (197), Expect = 1e-14
Identities = 50/133 (37%), Positives = 78/133 (58%), Gaps = 4/133 (3%)
Query: 1140 KPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEG 1199
K G AG RNA LHLA ++G+ +VK L++S A N D +G TPL A + G
Sbjct: 765 KHGANAGA---RNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGG 821
Query: 1200 SIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALD 1259
+++ LL+ GA +N N G LH+AV H+ E+LL +GA+ +++Q++A+D
Sbjct: 822 HHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVD 881
Query: 1260 EAD-DEKMKELLR 1271
A+ + K+ ELL+
Sbjct: 882 CAEQNSKIMELLQ 894
Score = 73.2 bits (178), Expect = 2e-12
Identities = 49/158 (31%), Positives = 82/158 (51%), Gaps = 5/158 (3%)
Query: 1134 KKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLH 1193
+K ++ P G +N + G S LH+A G L+ L++ GA+ + PLH
Sbjct: 724 QKRLAKVPASGLG-VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLH 782
Query: 1194 EASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQK 1253
A +G ++ LL + AK N +++ G PL A + H + +LLQ+GA+ N + K
Sbjct: 783 LACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNK 842
Query: 1254 QKSALDEADDEK---MKELLRSYGA-IETVNRDESDAI 1287
+AL EA EK + ELL +GA ++ +N+ + A+
Sbjct: 843 GNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAV 880
Score = 68.9 bits (167), Expect = 4e-11
Identities = 77/309 (24%), Positives = 121/309 (39%), Gaps = 62/309 (20%)
Query: 1101 NHLESETIHNIDSHSTDNMSKELANISKLSQREKKEISHKPGMKAGRIN--------KRN 1152
N E E + + + H D + K + EK + +GR+N R+
Sbjct: 409 NQKEVERLLSQEDHDKDTVQKMCHPLCFCDDCEK--------LVSGRLNDPSVVTPFSRD 460
Query: 1153 ARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEG--SIDIIVELLKA 1210
RG + LH+A G L+ L+ GA VN D G TPLH A +G S+ +++ KA
Sbjct: 461 DRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKA 520
Query: 1211 GAKV------------------------------NCE----NIDGILPLHDAVANNHLKA 1236
A+V +C N G PLH A +
Sbjct: 521 SAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGV 580
Query: 1237 AEILLQNGANPNQKDQKQKSALDEADDEKMKELLRSYGAIETVNRDESDAIVNEKIPAVR 1296
E LLQNGA+ +++ +++ L A + K+ ++ +Y + S+A P
Sbjct: 581 IETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEA------PVQS 634
Query: 1297 SKRHKQCFCDDGKTIDSSSLSHQERSRES----LSVHQTLSAILQDIEEKQEYLLEFEIR 1352
+R + T SS+S R E+ V + L A+ E YLLE+
Sbjct: 635 PQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEE 694
Query: 1353 NPEDAEQYI 1361
+ EDAE +
Sbjct: 695 DLEDAEDTV 703
Score = 55.8 bits (133), Expect = 4e-07
Identities = 46/139 (33%), Positives = 65/139 (46%), Gaps = 4/139 (2%)
Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
G + ++ AALH ADL+ +K G N + LH A G ++ LL A
Sbjct: 744 GSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKP 803
Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA---KDLCMKRLLE 605
N K L TPL A GH+++ LLL +GA N+ G AL EA K + + LL
Sbjct: 804 NKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLL 863
Query: 606 RYIPKHQKCLTSAQRSSID 624
+ Q L QR+++D
Sbjct: 864 LHGASVQ-VLNKRQRTAVD 881
Score = 42.7 bits (99), Expect = 0.003
Identities = 28/81 (34%), Positives = 39/81 (48%)
Query: 512 GGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVA 571
G VN S G + LH A++ G LLK GA+ + Q PLH A GH++V
Sbjct: 734 GLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVV 793
Query: 572 ELLLLNGADPLFRNDDGKCAL 592
+ LL + A P ++ G L
Sbjct: 794 KCLLDSNAKPNKKDLSGNTPL 814
Score = 40.0 bits (92), Expect = 0.021
Identities = 30/103 (29%), Positives = 45/103 (43%)
Query: 473 KVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVG 532
++N S+ + R+ G ++ AA+ A L+ + KG VN Y G T LH A
Sbjct: 447 RLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQK 506
Query: 533 GFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLL 575
G+ LL A ++ TPLH A GH + L+
Sbjct: 507 GYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALV 549
Score = 37.7 bits (86), Expect = 0.11
Identities = 33/104 (31%), Positives = 45/104 (43%), Gaps = 12/104 (11%)
Query: 513 GNVNQPSYA--------GWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVM 564
G +N PS G T LH A+V G L+ GA VN + TPLH A
Sbjct: 446 GRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQ 505
Query: 565 NGHYKVAELLLLNGADPLFRNDDGKCALDEA----KDLCMKRLL 604
G+ V LLL A ++++G L A + C+K L+
Sbjct: 506 KGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALV 549
Score = 35.4 bits (80), Expect = 0.53
Identities = 27/92 (29%), Positives = 42/92 (45%), Gaps = 2/92 (2%)
Query: 483 NRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELL 542
N++++ G + A +LV ++ G ++N + G TALHEA + LL
Sbjct: 804 NKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLL 863
Query: 543 KGGADVNIKGLYQITPLHDAVMNGHYKVAELL 574
GA V + Q T + A N K+ ELL
Sbjct: 864 LHGASVQVLNKRQRTAVDCAEQNS--KIMELL 893
>gi|18079216 CASK interacting protein 1 [Homo sapiens]
Length = 1431
Score = 80.1 bits (196), Expect = 2e-14
Identities = 49/143 (34%), Positives = 79/143 (55%), Gaps = 1/143 (0%)
Query: 1120 SKELANISKLSQREKKEISHKPGM-KAGRINKRNARGESQLHLAVRRGNLPLVKALIESG 1178
++++ +L QR + + G K +N ++ G S LH A GN L+ L+E+
Sbjct: 13 AEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQ 72
Query: 1179 ADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAE 1238
A V++ DN G PLH A+ +G + + +LKAG+ VN + +G +PLH A + H +E
Sbjct: 73 AAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSE 132
Query: 1239 ILLQNGANPNQKDQKQKSALDEA 1261
+LLQ+ +NP D K+ LD A
Sbjct: 133 MLLQHQSNPCMVDNSGKTPLDLA 155
Score = 54.7 bits (130), Expect = 8e-07
Identities = 35/115 (30%), Positives = 60/115 (52%)
Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
++N ++ G + ++ AAL+ + +L+ ++ V+ G LH A+ G
Sbjct: 41 NVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKL 100
Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
+LK G+ VNI PLH A +GHY V+E+LL + ++P ++ GK LD A
Sbjct: 101 VLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLA 155
Score = 52.4 bits (124), Expect = 4e-06
Identities = 41/136 (30%), Positives = 64/136 (47%), Gaps = 16/136 (11%)
Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNL--------NDNAGWTPLHEASNEGSIDIIVE 1206
G++ L LA G + +V+ L+ S L D G +PLH A+ G IDII
Sbjct: 148 GKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRL 207
Query: 1207 LLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALD------- 1259
LL+AG +N + G LH+A + +LL +G N + ++ ++ALD
Sbjct: 208 LLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTT 266
Query: 1260 EADDEKMKELLRSYGA 1275
++K+LLR A
Sbjct: 267 SQASREIKQLLREASA 282
Score = 42.4 bits (98), Expect = 0.004
Identities = 38/155 (24%), Positives = 62/155 (40%), Gaps = 42/155 (27%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
++ ++ +G LH A +G +K ++++G+ VN+ + G PLH A+ G D+ L
Sbjct: 75 VDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEML 134
Query: 1208 L-------------KAGAKVNCE----------------------------NIDGILPLH 1226
L K + CE + +G PLH
Sbjct: 135 LQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLH 194
Query: 1227 DAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
A N H+ +LLQ G + N + K +AL EA
Sbjct: 195 LAAKNGHIDIIRLLLQAGIDIN-RQTKSGTALHEA 228
Score = 37.0 bits (84), Expect = 0.18
Identities = 27/81 (33%), Positives = 40/81 (49%), Gaps = 3/81 (3%)
Query: 513 GNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAE 572
G+ P+ G + LH A+ G LL+ G D+N + T LH+A + G +V
Sbjct: 182 GDATDPN--GTSPLHLAAKNGHIDIIRLLLQAGIDIN-RQTKSGTALHEAALCGKTEVVR 238
Query: 573 LLLLNGADPLFRNDDGKCALD 593
LLL +G + RN + ALD
Sbjct: 239 LLLDSGINAHVRNTYSQTALD 259
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 79.3 bits (194), Expect = 3e-14
Identities = 66/241 (27%), Positives = 112/241 (46%), Gaps = 18/241 (7%)
Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
N N G + LHL + G++P+ LI+ G V+ G+TPLH AS+ G+I ++ LL
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721
Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKE 1268
+ A VN + G PLH A H +LL+NGA+PN+ + L A K
Sbjct: 722 QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA---KRLG 778
Query: 1269 LLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQERSRESLSV 1328
+ ++ V + S +V++K H+ F +T+D L E E L
Sbjct: 779 YISVTDVLKVVTDETSFVLVSDK--------HRMSF---PETVD-EILDVSEDEGEELIS 826
Query: 1329 HQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQKAERDDLAKK 1388
+ +D++E++E LL+F + + E + +I M + + E++ +K+
Sbjct: 827 FKAERRDSRDVDEEKE-LLDFVPKLDQVVES--PAIPRIPCAMPETVVIRSEEQEQASKE 883
Query: 1389 Y 1389
Y
Sbjct: 884 Y 884
Score = 75.1 bits (183), Expect = 6e-13
Identities = 38/102 (37%), Positives = 59/102 (57%)
Query: 1147 RINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVE 1206
++N + ++ LH A R G+ +VK L+E+ A+ NL AG TPLH A+ EG ++ ++
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521
Query: 1207 LLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
LL+ A C G PLH A ++ AE+LL+ A+PN
Sbjct: 522 LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
Score = 75.1 bits (183), Expect = 6e-13
Identities = 67/272 (24%), Positives = 121/272 (44%), Gaps = 13/272 (4%)
Query: 1130 SQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGW 1189
+++ + E++ G N + +G + LHLA + G+ +V L+ A+ NL + +G
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
Query: 1190 TPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQ 1249
TPLH + EG + + L+K G V+ G PLH A ++K + LLQ+ A+ N
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 1250 KDQKQKSALDEADDEKMKE----LLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFC 1305
K + S L +A + + LL++ + V+ D + + A+ +
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL------AIAKRLGYISVT 783
Query: 1306 DDGKTIDSSSLSHQERSRESLSVHQTLSAILQDIEEKQEYLLEF--EIRNPEDAEQYIEK 1363
D K + + + +S +T+ IL E++ E L+ F E R+ D ++ E
Sbjct: 784 DVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKEL 843
Query: 1364 MLKIKKIMDNVLAKQKAERDDLAKKYRVSIES 1395
+ + K +D V+ R A V I S
Sbjct: 844 LDFVPK-LDQVVESPAIPRIPCAMPETVVIRS 874
Score = 73.6 bits (179), Expect = 2e-12
Identities = 39/115 (33%), Positives = 64/115 (55%)
Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
K + N R G + LH+A ++ ++ +++ L+++GA ++ +G TPLH AS G + I
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSAL 1258
+ LL+ GA N N+ PLH A H + A+ LLQN A N K + ++ L
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474
Score = 70.9 bits (172), Expect = 1e-11
Identities = 39/107 (36%), Positives = 58/107 (54%)
Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
G + LH+A NL + + L+ GA VN G TPLH AS G++ ++ LL GA++
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
+ D + PLH A N H++ +EILL +GA K + S + A
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
Score = 70.1 bits (170), Expect = 2e-11
Identities = 38/94 (40%), Positives = 55/94 (58%)
Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
G + LH+A G+LP+VK L++ GA N+++ TPLH A+ G ++ LL+ AKV
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463
Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
N + D PLH A H ++LL+N ANPN
Sbjct: 464 NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Score = 68.9 bits (167), Expect = 4e-11
Identities = 37/101 (36%), Positives = 55/101 (54%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
IN N G + LHLA + G++ +V L+ + G T LH A+ G +++ EL
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97
Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
+ GA VN ++ G PL+ A NHL+ + LL+NGAN N
Sbjct: 98 VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Score = 68.2 bits (165), Expect = 7e-11
Identities = 34/100 (34%), Positives = 51/100 (51%)
Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
N G + LH+AV NL +VK L+ G + G+TPLH A+ + +++ LL
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
+ G N E++ G+ PLH A H + +LL AN N
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Score = 67.8 bits (164), Expect = 1e-10
Identities = 40/124 (32%), Positives = 61/124 (49%)
Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
N G + LH+A R G++ V AL+E A G+TPLH A+ G + + LL
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKE 1268
+ A N +G+ PLH AV +N+L ++LL G +P+ + L A + E
Sbjct: 557 ERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVE 616
Query: 1269 LLRS 1272
+ RS
Sbjct: 617 VARS 620
Score = 67.4 bits (163), Expect = 1e-10
Identities = 42/129 (32%), Positives = 65/129 (50%), Gaps = 4/129 (3%)
Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
LH+A G+ + K L++ GA N G+TPLH A + + ++ LLK GA ++
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA----DDEKMKELLRSYG 1274
G+ PLH A HL + LLQ GA+PN + K ++ L A E K LL++
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Query: 1275 AIETVNRDE 1283
+ +D+
Sbjct: 462 KVNAKAKDD 470
Score = 64.7 bits (156), Expect = 8e-10
Identities = 34/102 (33%), Positives = 53/102 (51%)
Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
+ +N G + LH+A RRGN+ +V+ L++ GA + TPLH A+ G + I
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287
Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGA 1245
LL GA + + +G+ P+H A +HL +LLQ A
Sbjct: 288 SEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 329
Score = 61.2 bits (147), Expect = 9e-09
Identities = 28/90 (31%), Positives = 49/90 (54%)
Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
G + LH+A ++ + + ++L++ G N G TPLH A+ EG +++ LL A
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNG 1244
N N G+ PLH H+ A++L+++G
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHG 691
Score = 60.5 bits (145), Expect = 2e-08
Identities = 29/92 (31%), Positives = 51/92 (55%)
Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
LH A R G++ + + L++ GA + G +P+H A+ +D + LL+ A+++
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335
Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQK 1250
+D + PLH A H + A++LL GA PN +
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367
Score = 60.5 bits (145), Expect = 2e-08
Identities = 47/180 (26%), Positives = 79/180 (43%), Gaps = 16/180 (8%)
Query: 466 SGKKEKMKVNKISLHSINRRNIFGEN---LVYKAALHDDADLVHHCIKKGGNVNQPSYAG 522
+ K K++V ++ L N G+N ++ A H++ D+V + +GG+ + P++ G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 523 WTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPL 582
+T LH A+ A LL+ G N + + +TPLH A GH ++ LLL A+
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 583 FRNDDGKCALDEAKDLCMKRLLERYIP------KHQKCLTSAQRSSIDPLDIEDVYQHKK 636
N G L E ++P KH + + R PL + Y + K
Sbjct: 663 LGNKSGLTPLHLVAQ-------EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Score = 60.1 bits (144), Expect = 2e-08
Identities = 32/101 (31%), Positives = 57/101 (56%), Gaps = 4/101 (3%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
+N ++ +G + L++A + +L +VK L+E+GA+ N+ G+TPL A +G +++ L
Sbjct: 104 VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
+ G K + LH A N+ + A +LLQN NP+
Sbjct: 164 INYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPD 200
Score = 60.1 bits (144), Expect = 2e-08
Identities = 36/117 (30%), Positives = 58/117 (49%)
Query: 1154 RGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAK 1213
+G + LH+A + G + + + L+E A N G TPLH A + ++DI+ LL G
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Query: 1214 VNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELL 1270
+ +G PLH A N ++ A LLQ G + N + + + L A E E++
Sbjct: 595 PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMV 651
Score = 59.7 bits (143), Expect = 3e-08
Identities = 33/99 (33%), Positives = 54/99 (54%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
I + G S +H+A + +L V+ L++ A+++ TPLH A++ G + L
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 357
Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGAN 1246
L GAK N ++G PLH A NH++ E+LL+ GA+
Sbjct: 358 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
Score = 57.0 bits (136), Expect = 2e-07
Identities = 37/90 (41%), Positives = 45/90 (50%)
Query: 509 IKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHY 568
IK G V+ + G+T LH AS G + LL+ ADVN K +PLH A GH
Sbjct: 688 IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 747
Query: 569 KVAELLLLNGADPLFRNDDGKCALDEAKDL 598
+ LLL NGA P + DG L AK L
Sbjct: 748 DIVTLLLKNGASPNEVSSDGTTPLAIAKRL 777
Score = 53.5 bits (127), Expect = 2e-06
Identities = 34/120 (28%), Positives = 60/120 (50%), Gaps = 3/120 (2%)
Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
LH+A R + L+++ + ++ G+TPLH A++ ++++ LL GA VN
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA---DDEKMKELLRSYGA 1275
+GI PLH A ++ +LL GA K + + + L A ++ E+L +GA
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296
Score = 52.0 bits (123), Expect = 5e-06
Identities = 30/84 (35%), Positives = 46/84 (54%)
Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
AA +++ ++ + +G +VN G T LH AS G LL GA + K +
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272
Query: 556 ITPLHDAVMNGHYKVAELLLLNGA 579
+TPLH A NGH +++E+LL +GA
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGA 296
Score = 50.4 bits (119), Expect = 2e-05
Identities = 39/122 (31%), Positives = 55/122 (45%), Gaps = 4/122 (3%)
Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
G + ++ AA D D V ++ ++ + T LH A+ G +R A LL GA
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364
Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDL----CMKRLL 604
N + L TPLH A H +V ELLL GA + G L A + +K LL
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
Query: 605 ER 606
+R
Sbjct: 425 QR 426
Score = 49.7 bits (117), Expect = 3e-05
Identities = 34/107 (31%), Positives = 51/107 (47%)
Query: 482 INRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASEL 541
IN N G N ++ A+ +V + K + + G TALH A++ G EL
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97
Query: 542 LKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDG 588
+ GA+VN + TPL+ A H +V + LL NGA+ +DG
Sbjct: 98 VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Score = 49.3 bits (116), Expect = 4e-05
Identities = 31/97 (31%), Positives = 48/97 (49%)
Query: 483 NRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELL 542
N R + G ++ A + ++ +K G +++ + +G T LH AS G LL
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
Query: 543 KGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579
+ GA N+ + TPLH A GH +VA+ LL N A
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Score = 48.5 bits (114), Expect = 6e-05
Identities = 36/117 (30%), Positives = 56/117 (47%), Gaps = 3/117 (2%)
Query: 468 KKEKMKVNKISLH---SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWT 524
KK ++V ++ L SI+ G ++ A+ +V + +++G + N + T
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439
Query: 525 ALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
LH A+ G A LL+ A VN K TPLH A GH + +LLL N A+P
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Score = 46.2 bits (108), Expect = 3e-04
Identities = 32/93 (34%), Positives = 40/93 (43%), Gaps = 5/93 (5%)
Query: 498 LHDDADLVHH-----CIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKG 552
LH A HH + KG N + G+T LH A R LLK GA ++
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 553 LYQITPLHDAVMNGHYKVAELLLLNGADPLFRN 585
+TPLH A GH + + LL GA P N
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Score = 44.7 bits (104), Expect = 9e-04
Identities = 34/115 (29%), Positives = 52/115 (45%)
Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
S N ++ G ++ AA A++V + K N N + +G T LH + G A
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 686
Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
L+K G V+ TPLH A G+ K+ + LL + AD + G L +A
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741
Score = 44.3 bits (103), Expect = 0.001
Identities = 28/90 (31%), Positives = 41/90 (45%)
Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
G ++ AAL ++V + G NVN S G+T L+ A+ LL+ GA+
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNG 578
N+ TPL A+ GH V L+ G
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 42.7 bits (99), Expect = 0.003
Identities = 34/123 (27%), Positives = 56/123 (45%), Gaps = 1/123 (0%)
Query: 512 GGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVA 571
G + + G + +H A+ G LL+ A+++ L +TPLH A GH++VA
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354
Query: 572 ELLLLNGADPLFRNDDGKCALDEAKDLCMKRLLERYIPKHQKCLTSAQRSSIDPLDIEDV 631
++LL GA P R +G L A R++E + K + + S + PL +
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL-KTGASIDAVTESGLTPLHVASF 413
Query: 632 YQH 634
H
Sbjct: 414 MGH 416
Score = 42.0 bits (97), Expect = 0.006
Identities = 29/93 (31%), Positives = 44/93 (47%)
Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
G ++ AA + V ++K + + G+T LH A+ G R A LL+ A
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562
Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
N G +TPLH AV + + + +LLL G P
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Score = 40.8 bits (94), Expect = 0.013
Identities = 33/100 (33%), Positives = 42/100 (42%)
Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
AA ++V ++ N N + AG T LH A+ G T LL+ A
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 556 ITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
TPLH A G +VAELLL A P +G L A
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576
Score = 39.7 bits (91), Expect = 0.028
Identities = 30/84 (35%), Positives = 38/84 (45%)
Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
AA +DD ++ N + S G+T LH A+ A LL GA VN
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 556 ITPLHDAVMNGHYKVAELLLLNGA 579
ITPLH A G+ + LLL GA
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGA 263
Score = 38.5 bits (88), Expect = 0.062
Identities = 27/101 (26%), Positives = 46/101 (45%), Gaps = 4/101 (3%)
Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
++N ++ G +Y AA + ++V ++ G N N + G+T L A G +
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 162
Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
L+ G KG ++ LH A N + A +LL N +P
Sbjct: 163 LINYGT----KGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Score = 35.0 bits (79), Expect = 0.69
Identities = 35/148 (23%), Positives = 57/148 (38%), Gaps = 1/148 (0%)
Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
S N N+ E ++ AA ++ + ++ VN + T LH A+ G
Sbjct: 429 SPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488
Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM 600
LL+ A+ N+ TPLH A GH + LL A G L A
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK 548
Query: 601 KRLLERYIPKHQKCLTSAQRSSIDPLDI 628
R+ E + + +A ++ + PL +
Sbjct: 549 VRVAELLLERDAH-PNAAGKNGLTPLHV 575
Score = 34.7 bits (78), Expect = 0.90
Identities = 28/114 (24%), Positives = 49/114 (42%), Gaps = 3/114 (2%)
Query: 470 EKMKVNKISLH---SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTAL 526
E + V ++ L+ S+N G ++ A+ + +V + +G + + T L
Sbjct: 217 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276
Query: 527 HEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGAD 580
H A+ G R + LL GA + K ++P+H A H LLL A+
Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
Score = 34.7 bits (78), Expect = 0.90
Identities = 24/86 (27%), Positives = 41/86 (47%)
Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
G ++ A+ + + LV ++ +VN + G++ LH+A+ G + LLK GA
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 549 NIKGLYQITPLHDAVMNGHYKVAELL 574
N TPL A G+ V ++L
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 79.3 bits (194), Expect = 3e-14
Identities = 66/241 (27%), Positives = 112/241 (46%), Gaps = 18/241 (7%)
Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
N N G + LHL + G++P+ LI+ G V+ G+TPLH AS+ G+I ++ LL
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721
Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKE 1268
+ A VN + G PLH A H +LL+NGA+PN+ + L A K
Sbjct: 722 QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA---KRLG 778
Query: 1269 LLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQERSRESLSV 1328
+ ++ V + S +V++K H+ F +T+D L E E L
Sbjct: 779 YISVTDVLKVVTDETSFVLVSDK--------HRMSF---PETVD-EILDVSEDEGEELIS 826
Query: 1329 HQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQKAERDDLAKK 1388
+ +D++E++E LL+F + + E + +I M + + E++ +K+
Sbjct: 827 FKAERRDSRDVDEEKE-LLDFVPKLDQVVES--PAIPRIPCAMPETVVIRSEEQEQASKE 883
Query: 1389 Y 1389
Y
Sbjct: 884 Y 884
Score = 75.1 bits (183), Expect = 6e-13
Identities = 38/102 (37%), Positives = 59/102 (57%)
Query: 1147 RINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVE 1206
++N + ++ LH A R G+ +VK L+E+ A+ NL AG TPLH A+ EG ++ ++
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521
Query: 1207 LLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
LL+ A C G PLH A ++ AE+LL+ A+PN
Sbjct: 522 LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
Score = 75.1 bits (183), Expect = 6e-13
Identities = 67/272 (24%), Positives = 121/272 (44%), Gaps = 13/272 (4%)
Query: 1130 SQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGW 1189
+++ + E++ G N + +G + LHLA + G+ +V L+ A+ NL + +G
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
Query: 1190 TPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQ 1249
TPLH + EG + + L+K G V+ G PLH A ++K + LLQ+ A+ N
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 1250 KDQKQKSALDEADDEKMKE----LLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFC 1305
K + S L +A + + LL++ + V+ D + + A+ +
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL------AIAKRLGYISVT 783
Query: 1306 DDGKTIDSSSLSHQERSRESLSVHQTLSAILQDIEEKQEYLLEF--EIRNPEDAEQYIEK 1363
D K + + + +S +T+ IL E++ E L+ F E R+ D ++ E
Sbjct: 784 DVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKEL 843
Query: 1364 MLKIKKIMDNVLAKQKAERDDLAKKYRVSIES 1395
+ + K +D V+ R A V I S
Sbjct: 844 LDFVPK-LDQVVESPAIPRIPCAMPETVVIRS 874
Score = 73.6 bits (179), Expect = 2e-12
Identities = 39/115 (33%), Positives = 64/115 (55%)
Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
K + N R G + LH+A ++ ++ +++ L+++GA ++ +G TPLH AS G + I
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSAL 1258
+ LL+ GA N N+ PLH A H + A+ LLQN A N K + ++ L
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474
Score = 70.9 bits (172), Expect = 1e-11
Identities = 39/107 (36%), Positives = 58/107 (54%)
Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
G + LH+A NL + + L+ GA VN G TPLH AS G++ ++ LL GA++
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
+ D + PLH A N H++ +EILL +GA K + S + A
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
Score = 70.1 bits (170), Expect = 2e-11
Identities = 38/94 (40%), Positives = 55/94 (58%)
Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
G + LH+A G+LP+VK L++ GA N+++ TPLH A+ G ++ LL+ AKV
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463
Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
N + D PLH A H ++LL+N ANPN
Sbjct: 464 NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Score = 68.9 bits (167), Expect = 4e-11
Identities = 37/101 (36%), Positives = 55/101 (54%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
IN N G + LHLA + G++ +V L+ + G T LH A+ G +++ EL
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97
Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
+ GA VN ++ G PL+ A NHL+ + LL+NGAN N
Sbjct: 98 VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Score = 68.2 bits (165), Expect = 7e-11
Identities = 34/100 (34%), Positives = 51/100 (51%)
Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
N G + LH+AV NL +VK L+ G + G+TPLH A+ + +++ LL
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
+ G N E++ G+ PLH A H + +LL AN N
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Score = 67.8 bits (164), Expect = 1e-10
Identities = 40/124 (32%), Positives = 61/124 (49%)
Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
N G + LH+A R G++ V AL+E A G+TPLH A+ G + + LL
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKE 1268
+ A N +G+ PLH AV +N+L ++LL G +P+ + L A + E
Sbjct: 557 ERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVE 616
Query: 1269 LLRS 1272
+ RS
Sbjct: 617 VARS 620
Score = 67.4 bits (163), Expect = 1e-10
Identities = 42/129 (32%), Positives = 65/129 (50%), Gaps = 4/129 (3%)
Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
LH+A G+ + K L++ GA N G+TPLH A + + ++ LLK GA ++
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA----DDEKMKELLRSYG 1274
G+ PLH A HL + LLQ GA+PN + K ++ L A E K LL++
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Query: 1275 AIETVNRDE 1283
+ +D+
Sbjct: 462 KVNAKAKDD 470
Score = 64.7 bits (156), Expect = 8e-10
Identities = 34/102 (33%), Positives = 53/102 (51%)
Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
+ +N G + LH+A RRGN+ +V+ L++ GA + TPLH A+ G + I
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287
Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGA 1245
LL GA + + +G+ P+H A +HL +LLQ A
Sbjct: 288 SEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 329
Score = 61.2 bits (147), Expect = 9e-09
Identities = 28/90 (31%), Positives = 49/90 (54%)
Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
G + LH+A ++ + + ++L++ G N G TPLH A+ EG +++ LL A
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNG 1244
N N G+ PLH H+ A++L+++G
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHG 691
Score = 60.5 bits (145), Expect = 2e-08
Identities = 29/92 (31%), Positives = 51/92 (55%)
Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
LH A R G++ + + L++ GA + G +P+H A+ +D + LL+ A+++
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335
Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQK 1250
+D + PLH A H + A++LL GA PN +
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367
Score = 60.5 bits (145), Expect = 2e-08
Identities = 47/180 (26%), Positives = 79/180 (43%), Gaps = 16/180 (8%)
Query: 466 SGKKEKMKVNKISLHSINRRNIFGEN---LVYKAALHDDADLVHHCIKKGGNVNQPSYAG 522
+ K K++V ++ L N G+N ++ A H++ D+V + +GG+ + P++ G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 523 WTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPL 582
+T LH A+ A LL+ G N + + +TPLH A GH ++ LLL A+
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 583 FRNDDGKCALDEAKDLCMKRLLERYIP------KHQKCLTSAQRSSIDPLDIEDVYQHKK 636
N G L E ++P KH + + R PL + Y + K
Sbjct: 663 LGNKSGLTPLHLVAQ-------EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Score = 60.1 bits (144), Expect = 2e-08
Identities = 32/101 (31%), Positives = 57/101 (56%), Gaps = 4/101 (3%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
+N ++ +G + L++A + +L +VK L+E+GA+ N+ G+TPL A +G +++ L
Sbjct: 104 VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
+ G K + LH A N+ + A +LLQN NP+
Sbjct: 164 INYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPD 200
Score = 60.1 bits (144), Expect = 2e-08
Identities = 36/117 (30%), Positives = 58/117 (49%)
Query: 1154 RGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAK 1213
+G + LH+A + G + + + L+E A N G TPLH A + ++DI+ LL G
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Query: 1214 VNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELL 1270
+ +G PLH A N ++ A LLQ G + N + + + L A E E++
Sbjct: 595 PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMV 651
Score = 59.7 bits (143), Expect = 3e-08
Identities = 33/99 (33%), Positives = 54/99 (54%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
I + G S +H+A + +L V+ L++ A+++ TPLH A++ G + L
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 357
Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGAN 1246
L GAK N ++G PLH A NH++ E+LL+ GA+
Sbjct: 358 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
Score = 57.0 bits (136), Expect = 2e-07
Identities = 37/90 (41%), Positives = 45/90 (50%)
Query: 509 IKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHY 568
IK G V+ + G+T LH AS G + LL+ ADVN K +PLH A GH
Sbjct: 688 IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 747
Query: 569 KVAELLLLNGADPLFRNDDGKCALDEAKDL 598
+ LLL NGA P + DG L AK L
Sbjct: 748 DIVTLLLKNGASPNEVSSDGTTPLAIAKRL 777
Score = 53.5 bits (127), Expect = 2e-06
Identities = 34/120 (28%), Positives = 60/120 (50%), Gaps = 3/120 (2%)
Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
LH+A R + L+++ + ++ G+TPLH A++ ++++ LL GA VN
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA---DDEKMKELLRSYGA 1275
+GI PLH A ++ +LL GA K + + + L A ++ E+L +GA
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296
Score = 52.0 bits (123), Expect = 5e-06
Identities = 30/84 (35%), Positives = 46/84 (54%)
Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
AA +++ ++ + +G +VN G T LH AS G LL GA + K +
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272
Query: 556 ITPLHDAVMNGHYKVAELLLLNGA 579
+TPLH A NGH +++E+LL +GA
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGA 296
Score = 50.4 bits (119), Expect = 2e-05
Identities = 39/122 (31%), Positives = 55/122 (45%), Gaps = 4/122 (3%)
Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
G + ++ AA D D V ++ ++ + T LH A+ G +R A LL GA
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364
Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDL----CMKRLL 604
N + L TPLH A H +V ELLL GA + G L A + +K LL
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
Query: 605 ER 606
+R
Sbjct: 425 QR 426
Score = 49.7 bits (117), Expect = 3e-05
Identities = 34/107 (31%), Positives = 51/107 (47%)
Query: 482 INRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASEL 541
IN N G N ++ A+ +V + K + + G TALH A++ G EL
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97
Query: 542 LKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDG 588
+ GA+VN + TPL+ A H +V + LL NGA+ +DG
Sbjct: 98 VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Score = 49.3 bits (116), Expect = 4e-05
Identities = 31/97 (31%), Positives = 48/97 (49%)
Query: 483 NRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELL 542
N R + G ++ A + ++ +K G +++ + +G T LH AS G LL
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
Query: 543 KGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579
+ GA N+ + TPLH A GH +VA+ LL N A
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Score = 48.5 bits (114), Expect = 6e-05
Identities = 36/117 (30%), Positives = 56/117 (47%), Gaps = 3/117 (2%)
Query: 468 KKEKMKVNKISLH---SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWT 524
KK ++V ++ L SI+ G ++ A+ +V + +++G + N + T
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439
Query: 525 ALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
LH A+ G A LL+ A VN K TPLH A GH + +LLL N A+P
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Score = 46.2 bits (108), Expect = 3e-04
Identities = 32/93 (34%), Positives = 40/93 (43%), Gaps = 5/93 (5%)
Query: 498 LHDDADLVHH-----CIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKG 552
LH A HH + KG N + G+T LH A R LLK GA ++
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 553 LYQITPLHDAVMNGHYKVAELLLLNGADPLFRN 585
+TPLH A GH + + LL GA P N
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Score = 44.7 bits (104), Expect = 9e-04
Identities = 34/115 (29%), Positives = 52/115 (45%)
Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
S N ++ G ++ AA A++V + K N N + +G T LH + G A
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 686
Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
L+K G V+ TPLH A G+ K+ + LL + AD + G L +A
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741
Score = 44.3 bits (103), Expect = 0.001
Identities = 28/90 (31%), Positives = 41/90 (45%)
Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
G ++ AAL ++V + G NVN S G+T L+ A+ LL+ GA+
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNG 578
N+ TPL A+ GH V L+ G
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 42.7 bits (99), Expect = 0.003
Identities = 34/123 (27%), Positives = 56/123 (45%), Gaps = 1/123 (0%)
Query: 512 GGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVA 571
G + + G + +H A+ G LL+ A+++ L +TPLH A GH++VA
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354
Query: 572 ELLLLNGADPLFRNDDGKCALDEAKDLCMKRLLERYIPKHQKCLTSAQRSSIDPLDIEDV 631
++LL GA P R +G L A R++E + K + + S + PL +
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL-KTGASIDAVTESGLTPLHVASF 413
Query: 632 YQH 634
H
Sbjct: 414 MGH 416
Score = 42.0 bits (97), Expect = 0.006
Identities = 29/93 (31%), Positives = 44/93 (47%)
Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
G ++ AA + V ++K + + G+T LH A+ G R A LL+ A
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562
Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
N G +TPLH AV + + + +LLL G P
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Score = 40.8 bits (94), Expect = 0.013
Identities = 33/100 (33%), Positives = 42/100 (42%)
Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
AA ++V ++ N N + AG T LH A+ G T LL+ A
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 556 ITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
TPLH A G +VAELLL A P +G L A
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576
Score = 39.7 bits (91), Expect = 0.028
Identities = 30/84 (35%), Positives = 38/84 (45%)
Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
AA +DD ++ N + S G+T LH A+ A LL GA VN
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 556 ITPLHDAVMNGHYKVAELLLLNGA 579
ITPLH A G+ + LLL GA
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGA 263
Score = 38.5 bits (88), Expect = 0.062
Identities = 27/101 (26%), Positives = 46/101 (45%), Gaps = 4/101 (3%)
Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
++N ++ G +Y AA + ++V ++ G N N + G+T L A G +
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 162
Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
L+ G KG ++ LH A N + A +LL N +P
Sbjct: 163 LINYGT----KGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Score = 35.0 bits (79), Expect = 0.69
Identities = 35/148 (23%), Positives = 57/148 (38%), Gaps = 1/148 (0%)
Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
S N N+ E ++ AA ++ + ++ VN + T LH A+ G
Sbjct: 429 SPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488
Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM 600
LL+ A+ N+ TPLH A GH + LL A G L A
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK 548
Query: 601 KRLLERYIPKHQKCLTSAQRSSIDPLDI 628
R+ E + + +A ++ + PL +
Sbjct: 549 VRVAELLLERDAH-PNAAGKNGLTPLHV 575
Score = 34.7 bits (78), Expect = 0.90
Identities = 28/114 (24%), Positives = 49/114 (42%), Gaps = 3/114 (2%)
Query: 470 EKMKVNKISLH---SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTAL 526
E + V ++ L+ S+N G ++ A+ + +V + +G + + T L
Sbjct: 217 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276
Query: 527 HEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGAD 580
H A+ G R + LL GA + K ++P+H A H LLL A+
Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
Score = 34.7 bits (78), Expect = 0.90
Identities = 24/86 (27%), Positives = 41/86 (47%)
Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
G ++ A+ + + LV ++ +VN + G++ LH+A+ G + LLK GA
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 549 NIKGLYQITPLHDAVMNGHYKVAELL 574
N TPL A G+ V ++L
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 79.3 bits (194), Expect = 3e-14
Identities = 66/241 (27%), Positives = 112/241 (46%), Gaps = 18/241 (7%)
Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
N N G + LHL + G++P+ LI+ G V+ G+TPLH AS+ G+I ++ LL
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721
Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKE 1268
+ A VN + G PLH A H +LL+NGA+PN+ + L A K
Sbjct: 722 QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA---KRLG 778
Query: 1269 LLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQERSRESLSV 1328
+ ++ V + S +V++K H+ F +T+D L E E L
Sbjct: 779 YISVTDVLKVVTDETSFVLVSDK--------HRMSF---PETVD-EILDVSEDEGEELIS 826
Query: 1329 HQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQKAERDDLAKK 1388
+ +D++E++E LL+F + + E + +I M + + E++ +K+
Sbjct: 827 FKAERRDSRDVDEEKE-LLDFVPKLDQVVES--PAIPRIPCAMPETVVIRSEEQEQASKE 883
Query: 1389 Y 1389
Y
Sbjct: 884 Y 884
Score = 75.1 bits (183), Expect = 6e-13
Identities = 38/102 (37%), Positives = 59/102 (57%)
Query: 1147 RINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVE 1206
++N + ++ LH A R G+ +VK L+E+ A+ NL AG TPLH A+ EG ++ ++
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521
Query: 1207 LLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
LL+ A C G PLH A ++ AE+LL+ A+PN
Sbjct: 522 LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
Score = 75.1 bits (183), Expect = 6e-13
Identities = 67/272 (24%), Positives = 121/272 (44%), Gaps = 13/272 (4%)
Query: 1130 SQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGW 1189
+++ + E++ G N + +G + LHLA + G+ +V L+ A+ NL + +G
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
Query: 1190 TPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQ 1249
TPLH + EG + + L+K G V+ G PLH A ++K + LLQ+ A+ N
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 1250 KDQKQKSALDEADDEKMKE----LLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFC 1305
K + S L +A + + LL++ + V+ D + + A+ +
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL------AIAKRLGYISVT 783
Query: 1306 DDGKTIDSSSLSHQERSRESLSVHQTLSAILQDIEEKQEYLLEF--EIRNPEDAEQYIEK 1363
D K + + + +S +T+ IL E++ E L+ F E R+ D ++ E
Sbjct: 784 DVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKEL 843
Query: 1364 MLKIKKIMDNVLAKQKAERDDLAKKYRVSIES 1395
+ + K +D V+ R A V I S
Sbjct: 844 LDFVPK-LDQVVESPAIPRIPCAMPETVVIRS 874
Score = 73.6 bits (179), Expect = 2e-12
Identities = 39/115 (33%), Positives = 64/115 (55%)
Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
K + N R G + LH+A ++ ++ +++ L+++GA ++ +G TPLH AS G + I
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSAL 1258
+ LL+ GA N N+ PLH A H + A+ LLQN A N K + ++ L
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474
Score = 70.9 bits (172), Expect = 1e-11
Identities = 39/107 (36%), Positives = 58/107 (54%)
Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
G + LH+A NL + + L+ GA VN G TPLH AS G++ ++ LL GA++
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
+ D + PLH A N H++ +EILL +GA K + S + A
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
Score = 70.1 bits (170), Expect = 2e-11
Identities = 38/94 (40%), Positives = 55/94 (58%)
Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
G + LH+A G+LP+VK L++ GA N+++ TPLH A+ G ++ LL+ AKV
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463
Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
N + D PLH A H ++LL+N ANPN
Sbjct: 464 NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Score = 68.9 bits (167), Expect = 4e-11
Identities = 37/101 (36%), Positives = 55/101 (54%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
IN N G + LHLA + G++ +V L+ + G T LH A+ G +++ EL
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97
Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
+ GA VN ++ G PL+ A NHL+ + LL+NGAN N
Sbjct: 98 VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Score = 68.2 bits (165), Expect = 7e-11
Identities = 34/100 (34%), Positives = 51/100 (51%)
Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
N G + LH+AV NL +VK L+ G + G+TPLH A+ + +++ LL
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
+ G N E++ G+ PLH A H + +LL AN N
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Score = 67.8 bits (164), Expect = 1e-10
Identities = 40/124 (32%), Positives = 61/124 (49%)
Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
N G + LH+A R G++ V AL+E A G+TPLH A+ G + + LL
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKE 1268
+ A N +G+ PLH AV +N+L ++LL G +P+ + L A + E
Sbjct: 557 ERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVE 616
Query: 1269 LLRS 1272
+ RS
Sbjct: 617 VARS 620
Score = 67.4 bits (163), Expect = 1e-10
Identities = 42/129 (32%), Positives = 65/129 (50%), Gaps = 4/129 (3%)
Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
LH+A G+ + K L++ GA N G+TPLH A + + ++ LLK GA ++
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA----DDEKMKELLRSYG 1274
G+ PLH A HL + LLQ GA+PN + K ++ L A E K LL++
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Query: 1275 AIETVNRDE 1283
+ +D+
Sbjct: 462 KVNAKAKDD 470
Score = 64.7 bits (156), Expect = 8e-10
Identities = 34/102 (33%), Positives = 53/102 (51%)
Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
+ +N G + LH+A RRGN+ +V+ L++ GA + TPLH A+ G + I
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287
Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGA 1245
LL GA + + +G+ P+H A +HL +LLQ A
Sbjct: 288 SEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 329
Score = 61.2 bits (147), Expect = 9e-09
Identities = 28/90 (31%), Positives = 49/90 (54%)
Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
G + LH+A ++ + + ++L++ G N G TPLH A+ EG +++ LL A
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNG 1244
N N G+ PLH H+ A++L+++G
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHG 691
Score = 60.5 bits (145), Expect = 2e-08
Identities = 29/92 (31%), Positives = 51/92 (55%)
Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
LH A R G++ + + L++ GA + G +P+H A+ +D + LL+ A+++
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335
Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQK 1250
+D + PLH A H + A++LL GA PN +
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367
Score = 60.5 bits (145), Expect = 2e-08
Identities = 47/180 (26%), Positives = 79/180 (43%), Gaps = 16/180 (8%)
Query: 466 SGKKEKMKVNKISLHSINRRNIFGEN---LVYKAALHDDADLVHHCIKKGGNVNQPSYAG 522
+ K K++V ++ L N G+N ++ A H++ D+V + +GG+ + P++ G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 523 WTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPL 582
+T LH A+ A LL+ G N + + +TPLH A GH ++ LLL A+
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 583 FRNDDGKCALDEAKDLCMKRLLERYIP------KHQKCLTSAQRSSIDPLDIEDVYQHKK 636
N G L E ++P KH + + R PL + Y + K
Sbjct: 663 LGNKSGLTPLHLVAQ-------EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Score = 60.1 bits (144), Expect = 2e-08
Identities = 32/101 (31%), Positives = 57/101 (56%), Gaps = 4/101 (3%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
+N ++ +G + L++A + +L +VK L+E+GA+ N+ G+TPL A +G +++ L
Sbjct: 104 VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
+ G K + LH A N+ + A +LLQN NP+
Sbjct: 164 INYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPD 200
Score = 60.1 bits (144), Expect = 2e-08
Identities = 36/117 (30%), Positives = 58/117 (49%)
Query: 1154 RGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAK 1213
+G + LH+A + G + + + L+E A N G TPLH A + ++DI+ LL G
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Query: 1214 VNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELL 1270
+ +G PLH A N ++ A LLQ G + N + + + L A E E++
Sbjct: 595 PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMV 651
Score = 59.7 bits (143), Expect = 3e-08
Identities = 33/99 (33%), Positives = 54/99 (54%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
I + G S +H+A + +L V+ L++ A+++ TPLH A++ G + L
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 357
Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGAN 1246
L GAK N ++G PLH A NH++ E+LL+ GA+
Sbjct: 358 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
Score = 57.0 bits (136), Expect = 2e-07
Identities = 37/90 (41%), Positives = 45/90 (50%)
Query: 509 IKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHY 568
IK G V+ + G+T LH AS G + LL+ ADVN K +PLH A GH
Sbjct: 688 IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 747
Query: 569 KVAELLLLNGADPLFRNDDGKCALDEAKDL 598
+ LLL NGA P + DG L AK L
Sbjct: 748 DIVTLLLKNGASPNEVSSDGTTPLAIAKRL 777
Score = 53.5 bits (127), Expect = 2e-06
Identities = 34/120 (28%), Positives = 60/120 (50%), Gaps = 3/120 (2%)
Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
LH+A R + L+++ + ++ G+TPLH A++ ++++ LL GA VN
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA---DDEKMKELLRSYGA 1275
+GI PLH A ++ +LL GA K + + + L A ++ E+L +GA
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296
Score = 52.0 bits (123), Expect = 5e-06
Identities = 30/84 (35%), Positives = 46/84 (54%)
Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
AA +++ ++ + +G +VN G T LH AS G LL GA + K +
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272
Query: 556 ITPLHDAVMNGHYKVAELLLLNGA 579
+TPLH A NGH +++E+LL +GA
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGA 296
Score = 50.4 bits (119), Expect = 2e-05
Identities = 39/122 (31%), Positives = 55/122 (45%), Gaps = 4/122 (3%)
Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
G + ++ AA D D V ++ ++ + T LH A+ G +R A LL GA
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364
Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDL----CMKRLL 604
N + L TPLH A H +V ELLL GA + G L A + +K LL
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
Query: 605 ER 606
+R
Sbjct: 425 QR 426
Score = 49.7 bits (117), Expect = 3e-05
Identities = 34/107 (31%), Positives = 51/107 (47%)
Query: 482 INRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASEL 541
IN N G N ++ A+ +V + K + + G TALH A++ G EL
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97
Query: 542 LKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDG 588
+ GA+VN + TPL+ A H +V + LL NGA+ +DG
Sbjct: 98 VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Score = 49.3 bits (116), Expect = 4e-05
Identities = 31/97 (31%), Positives = 48/97 (49%)
Query: 483 NRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELL 542
N R + G ++ A + ++ +K G +++ + +G T LH AS G LL
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
Query: 543 KGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579
+ GA N+ + TPLH A GH +VA+ LL N A
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Score = 48.5 bits (114), Expect = 6e-05
Identities = 36/117 (30%), Positives = 56/117 (47%), Gaps = 3/117 (2%)
Query: 468 KKEKMKVNKISLH---SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWT 524
KK ++V ++ L SI+ G ++ A+ +V + +++G + N + T
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439
Query: 525 ALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
LH A+ G A LL+ A VN K TPLH A GH + +LLL N A+P
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Score = 46.2 bits (108), Expect = 3e-04
Identities = 32/93 (34%), Positives = 40/93 (43%), Gaps = 5/93 (5%)
Query: 498 LHDDADLVHH-----CIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKG 552
LH A HH + KG N + G+T LH A R LLK GA ++
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 553 LYQITPLHDAVMNGHYKVAELLLLNGADPLFRN 585
+TPLH A GH + + LL GA P N
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Score = 44.7 bits (104), Expect = 9e-04
Identities = 34/115 (29%), Positives = 52/115 (45%)
Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
S N ++ G ++ AA A++V + K N N + +G T LH + G A
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 686
Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
L+K G V+ TPLH A G+ K+ + LL + AD + G L +A
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741
Score = 44.3 bits (103), Expect = 0.001
Identities = 28/90 (31%), Positives = 41/90 (45%)
Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
G ++ AAL ++V + G NVN S G+T L+ A+ LL+ GA+
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNG 578
N+ TPL A+ GH V L+ G
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 42.7 bits (99), Expect = 0.003
Identities = 34/123 (27%), Positives = 56/123 (45%), Gaps = 1/123 (0%)
Query: 512 GGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVA 571
G + + G + +H A+ G LL+ A+++ L +TPLH A GH++VA
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354
Query: 572 ELLLLNGADPLFRNDDGKCALDEAKDLCMKRLLERYIPKHQKCLTSAQRSSIDPLDIEDV 631
++LL GA P R +G L A R++E + K + + S + PL +
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL-KTGASIDAVTESGLTPLHVASF 413
Query: 632 YQH 634
H
Sbjct: 414 MGH 416
Score = 42.0 bits (97), Expect = 0.006
Identities = 29/93 (31%), Positives = 44/93 (47%)
Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
G ++ AA + V ++K + + G+T LH A+ G R A LL+ A
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562
Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
N G +TPLH AV + + + +LLL G P
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Score = 40.8 bits (94), Expect = 0.013
Identities = 33/100 (33%), Positives = 42/100 (42%)
Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
AA ++V ++ N N + AG T LH A+ G T LL+ A
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 556 ITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
TPLH A G +VAELLL A P +G L A
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576
Score = 39.7 bits (91), Expect = 0.028
Identities = 30/84 (35%), Positives = 38/84 (45%)
Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
AA +DD ++ N + S G+T LH A+ A LL GA VN
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 556 ITPLHDAVMNGHYKVAELLLLNGA 579
ITPLH A G+ + LLL GA
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGA 263
Score = 38.5 bits (88), Expect = 0.062
Identities = 27/101 (26%), Positives = 46/101 (45%), Gaps = 4/101 (3%)
Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
++N ++ G +Y AA + ++V ++ G N N + G+T L A G +
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 162
Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
L+ G KG ++ LH A N + A +LL N +P
Sbjct: 163 LINYGT----KGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Score = 35.0 bits (79), Expect = 0.69
Identities = 35/148 (23%), Positives = 57/148 (38%), Gaps = 1/148 (0%)
Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
S N N+ E ++ AA ++ + ++ VN + T LH A+ G
Sbjct: 429 SPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488
Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM 600
LL+ A+ N+ TPLH A GH + LL A G L A
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK 548
Query: 601 KRLLERYIPKHQKCLTSAQRSSIDPLDI 628
R+ E + + +A ++ + PL +
Sbjct: 549 VRVAELLLERDAH-PNAAGKNGLTPLHV 575
Score = 34.7 bits (78), Expect = 0.90
Identities = 28/114 (24%), Positives = 49/114 (42%), Gaps = 3/114 (2%)
Query: 470 EKMKVNKISLH---SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTAL 526
E + V ++ L+ S+N G ++ A+ + +V + +G + + T L
Sbjct: 217 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276
Query: 527 HEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGAD 580
H A+ G R + LL GA + K ++P+H A H LLL A+
Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
Score = 34.7 bits (78), Expect = 0.90
Identities = 24/86 (27%), Positives = 41/86 (47%)
Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
G ++ A+ + + LV ++ +VN + G++ LH+A+ G + LLK GA
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 549 NIKGLYQITPLHDAVMNGHYKVAELL 574
N TPL A G+ V ++L
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 79.3 bits (194), Expect = 3e-14
Identities = 66/241 (27%), Positives = 112/241 (46%), Gaps = 18/241 (7%)
Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
N N G + LHL + G++P+ LI+ G V+ G+TPLH AS+ G+I ++ LL
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721
Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKE 1268
+ A VN + G PLH A H +LL+NGA+PN+ + L A K
Sbjct: 722 QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA---KRLG 778
Query: 1269 LLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQERSRESLSV 1328
+ ++ V + S +V++K H+ F +T+D L E E L
Sbjct: 779 YISVTDVLKVVTDETSFVLVSDK--------HRMSF---PETVD-EILDVSEDEGEELIS 826
Query: 1329 HQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQKAERDDLAKK 1388
+ +D++E++E LL+F + + E + +I M + + E++ +K+
Sbjct: 827 FKAERRDSRDVDEEKE-LLDFVPKLDQVVES--PAIPRIPCAMPETVVIRSEEQEQASKE 883
Query: 1389 Y 1389
Y
Sbjct: 884 Y 884
Score = 75.1 bits (183), Expect = 6e-13
Identities = 38/102 (37%), Positives = 59/102 (57%)
Query: 1147 RINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVE 1206
++N + ++ LH A R G+ +VK L+E+ A+ NL AG TPLH A+ EG ++ ++
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521
Query: 1207 LLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
LL+ A C G PLH A ++ AE+LL+ A+PN
Sbjct: 522 LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
Score = 75.1 bits (183), Expect = 6e-13
Identities = 67/272 (24%), Positives = 121/272 (44%), Gaps = 13/272 (4%)
Query: 1130 SQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGW 1189
+++ + E++ G N + +G + LHLA + G+ +V L+ A+ NL + +G
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
Query: 1190 TPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQ 1249
TPLH + EG + + L+K G V+ G PLH A ++K + LLQ+ A+ N
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 1250 KDQKQKSALDEADDEKMKE----LLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFC 1305
K + S L +A + + LL++ + V+ D + + A+ +
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL------AIAKRLGYISVT 783
Query: 1306 DDGKTIDSSSLSHQERSRESLSVHQTLSAILQDIEEKQEYLLEF--EIRNPEDAEQYIEK 1363
D K + + + +S +T+ IL E++ E L+ F E R+ D ++ E
Sbjct: 784 DVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKEL 843
Query: 1364 MLKIKKIMDNVLAKQKAERDDLAKKYRVSIES 1395
+ + K +D V+ R A V I S
Sbjct: 844 LDFVPK-LDQVVESPAIPRIPCAMPETVVIRS 874
Score = 73.6 bits (179), Expect = 2e-12
Identities = 39/115 (33%), Positives = 64/115 (55%)
Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
K + N R G + LH+A ++ ++ +++ L+++GA ++ +G TPLH AS G + I
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSAL 1258
+ LL+ GA N N+ PLH A H + A+ LLQN A N K + ++ L
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474
Score = 70.9 bits (172), Expect = 1e-11
Identities = 39/107 (36%), Positives = 58/107 (54%)
Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
G + LH+A NL + + L+ GA VN G TPLH AS G++ ++ LL GA++
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
+ D + PLH A N H++ +EILL +GA K + S + A
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
Score = 70.1 bits (170), Expect = 2e-11
Identities = 38/94 (40%), Positives = 55/94 (58%)
Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
G + LH+A G+LP+VK L++ GA N+++ TPLH A+ G ++ LL+ AKV
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463
Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
N + D PLH A H ++LL+N ANPN
Sbjct: 464 NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Score = 68.9 bits (167), Expect = 4e-11
Identities = 37/101 (36%), Positives = 55/101 (54%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
IN N G + LHLA + G++ +V L+ + G T LH A+ G +++ EL
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97
Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
+ GA VN ++ G PL+ A NHL+ + LL+NGAN N
Sbjct: 98 VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Score = 68.2 bits (165), Expect = 7e-11
Identities = 34/100 (34%), Positives = 51/100 (51%)
Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
N G + LH+AV NL +VK L+ G + G+TPLH A+ + +++ LL
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
+ G N E++ G+ PLH A H + +LL AN N
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Score = 67.8 bits (164), Expect = 1e-10
Identities = 40/124 (32%), Positives = 61/124 (49%)
Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
N G + LH+A R G++ V AL+E A G+TPLH A+ G + + LL
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKE 1268
+ A N +G+ PLH AV +N+L ++LL G +P+ + L A + E
Sbjct: 557 ERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVE 616
Query: 1269 LLRS 1272
+ RS
Sbjct: 617 VARS 620
Score = 67.4 bits (163), Expect = 1e-10
Identities = 42/129 (32%), Positives = 65/129 (50%), Gaps = 4/129 (3%)
Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
LH+A G+ + K L++ GA N G+TPLH A + + ++ LLK GA ++
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA----DDEKMKELLRSYG 1274
G+ PLH A HL + LLQ GA+PN + K ++ L A E K LL++
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Query: 1275 AIETVNRDE 1283
+ +D+
Sbjct: 462 KVNAKAKDD 470
Score = 64.7 bits (156), Expect = 8e-10
Identities = 34/102 (33%), Positives = 53/102 (51%)
Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
+ +N G + LH+A RRGN+ +V+ L++ GA + TPLH A+ G + I
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287
Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGA 1245
LL GA + + +G+ P+H A +HL +LLQ A
Sbjct: 288 SEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 329
Score = 61.2 bits (147), Expect = 9e-09
Identities = 28/90 (31%), Positives = 49/90 (54%)
Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
G + LH+A ++ + + ++L++ G N G TPLH A+ EG +++ LL A
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNG 1244
N N G+ PLH H+ A++L+++G
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHG 691
Score = 60.5 bits (145), Expect = 2e-08
Identities = 29/92 (31%), Positives = 51/92 (55%)
Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
LH A R G++ + + L++ GA + G +P+H A+ +D + LL+ A+++
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335
Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQK 1250
+D + PLH A H + A++LL GA PN +
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367
Score = 60.5 bits (145), Expect = 2e-08
Identities = 47/180 (26%), Positives = 79/180 (43%), Gaps = 16/180 (8%)
Query: 466 SGKKEKMKVNKISLHSINRRNIFGEN---LVYKAALHDDADLVHHCIKKGGNVNQPSYAG 522
+ K K++V ++ L N G+N ++ A H++ D+V + +GG+ + P++ G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 523 WTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPL 582
+T LH A+ A LL+ G N + + +TPLH A GH ++ LLL A+
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 583 FRNDDGKCALDEAKDLCMKRLLERYIP------KHQKCLTSAQRSSIDPLDIEDVYQHKK 636
N G L E ++P KH + + R PL + Y + K
Sbjct: 663 LGNKSGLTPLHLVAQ-------EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Score = 60.1 bits (144), Expect = 2e-08
Identities = 32/101 (31%), Positives = 57/101 (56%), Gaps = 4/101 (3%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
+N ++ +G + L++A + +L +VK L+E+GA+ N+ G+TPL A +G +++ L
Sbjct: 104 VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
+ G K + LH A N+ + A +LLQN NP+
Sbjct: 164 INYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPD 200
Score = 60.1 bits (144), Expect = 2e-08
Identities = 36/117 (30%), Positives = 58/117 (49%)
Query: 1154 RGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAK 1213
+G + LH+A + G + + + L+E A N G TPLH A + ++DI+ LL G
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Query: 1214 VNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELL 1270
+ +G PLH A N ++ A LLQ G + N + + + L A E E++
Sbjct: 595 PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMV 651
Score = 59.7 bits (143), Expect = 3e-08
Identities = 33/99 (33%), Positives = 54/99 (54%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
I + G S +H+A + +L V+ L++ A+++ TPLH A++ G + L
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 357
Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGAN 1246
L GAK N ++G PLH A NH++ E+LL+ GA+
Sbjct: 358 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
Score = 57.0 bits (136), Expect = 2e-07
Identities = 37/90 (41%), Positives = 45/90 (50%)
Query: 509 IKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHY 568
IK G V+ + G+T LH AS G + LL+ ADVN K +PLH A GH
Sbjct: 688 IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 747
Query: 569 KVAELLLLNGADPLFRNDDGKCALDEAKDL 598
+ LLL NGA P + DG L AK L
Sbjct: 748 DIVTLLLKNGASPNEVSSDGTTPLAIAKRL 777
Score = 53.5 bits (127), Expect = 2e-06
Identities = 34/120 (28%), Positives = 60/120 (50%), Gaps = 3/120 (2%)
Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
LH+A R + L+++ + ++ G+TPLH A++ ++++ LL GA VN
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA---DDEKMKELLRSYGA 1275
+GI PLH A ++ +LL GA K + + + L A ++ E+L +GA
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296
Score = 52.0 bits (123), Expect = 5e-06
Identities = 30/84 (35%), Positives = 46/84 (54%)
Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
AA +++ ++ + +G +VN G T LH AS G LL GA + K +
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272
Query: 556 ITPLHDAVMNGHYKVAELLLLNGA 579
+TPLH A NGH +++E+LL +GA
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGA 296
Score = 50.4 bits (119), Expect = 2e-05
Identities = 39/122 (31%), Positives = 55/122 (45%), Gaps = 4/122 (3%)
Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
G + ++ AA D D V ++ ++ + T LH A+ G +R A LL GA
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364
Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDL----CMKRLL 604
N + L TPLH A H +V ELLL GA + G L A + +K LL
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
Query: 605 ER 606
+R
Sbjct: 425 QR 426
Score = 49.7 bits (117), Expect = 3e-05
Identities = 34/107 (31%), Positives = 51/107 (47%)
Query: 482 INRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASEL 541
IN N G N ++ A+ +V + K + + G TALH A++ G EL
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97
Query: 542 LKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDG 588
+ GA+VN + TPL+ A H +V + LL NGA+ +DG
Sbjct: 98 VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Score = 49.3 bits (116), Expect = 4e-05
Identities = 31/97 (31%), Positives = 48/97 (49%)
Query: 483 NRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELL 542
N R + G ++ A + ++ +K G +++ + +G T LH AS G LL
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
Query: 543 KGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579
+ GA N+ + TPLH A GH +VA+ LL N A
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Score = 48.5 bits (114), Expect = 6e-05
Identities = 36/117 (30%), Positives = 56/117 (47%), Gaps = 3/117 (2%)
Query: 468 KKEKMKVNKISLH---SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWT 524
KK ++V ++ L SI+ G ++ A+ +V + +++G + N + T
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439
Query: 525 ALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
LH A+ G A LL+ A VN K TPLH A GH + +LLL N A+P
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Score = 46.2 bits (108), Expect = 3e-04
Identities = 32/93 (34%), Positives = 40/93 (43%), Gaps = 5/93 (5%)
Query: 498 LHDDADLVHH-----CIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKG 552
LH A HH + KG N + G+T LH A R LLK GA ++
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 553 LYQITPLHDAVMNGHYKVAELLLLNGADPLFRN 585
+TPLH A GH + + LL GA P N
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Score = 44.7 bits (104), Expect = 9e-04
Identities = 34/115 (29%), Positives = 52/115 (45%)
Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
S N ++ G ++ AA A++V + K N N + +G T LH + G A
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 686
Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
L+K G V+ TPLH A G+ K+ + LL + AD + G L +A
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741
Score = 44.3 bits (103), Expect = 0.001
Identities = 28/90 (31%), Positives = 41/90 (45%)
Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
G ++ AAL ++V + G NVN S G+T L+ A+ LL+ GA+
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNG 578
N+ TPL A+ GH V L+ G
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 42.7 bits (99), Expect = 0.003
Identities = 34/123 (27%), Positives = 56/123 (45%), Gaps = 1/123 (0%)
Query: 512 GGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVA 571
G + + G + +H A+ G LL+ A+++ L +TPLH A GH++VA
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354
Query: 572 ELLLLNGADPLFRNDDGKCALDEAKDLCMKRLLERYIPKHQKCLTSAQRSSIDPLDIEDV 631
++LL GA P R +G L A R++E + K + + S + PL +
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL-KTGASIDAVTESGLTPLHVASF 413
Query: 632 YQH 634
H
Sbjct: 414 MGH 416
Score = 42.0 bits (97), Expect = 0.006
Identities = 29/93 (31%), Positives = 44/93 (47%)
Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
G ++ AA + V ++K + + G+T LH A+ G R A LL+ A
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562
Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
N G +TPLH AV + + + +LLL G P
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Score = 40.8 bits (94), Expect = 0.013
Identities = 33/100 (33%), Positives = 42/100 (42%)
Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
AA ++V ++ N N + AG T LH A+ G T LL+ A
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 556 ITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
TPLH A G +VAELLL A P +G L A
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576
Score = 39.7 bits (91), Expect = 0.028
Identities = 30/84 (35%), Positives = 38/84 (45%)
Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
AA +DD ++ N + S G+T LH A+ A LL GA VN
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 556 ITPLHDAVMNGHYKVAELLLLNGA 579
ITPLH A G+ + LLL GA
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGA 263
Score = 38.5 bits (88), Expect = 0.062
Identities = 27/101 (26%), Positives = 46/101 (45%), Gaps = 4/101 (3%)
Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
++N ++ G +Y AA + ++V ++ G N N + G+T L A G +
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 162
Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
L+ G KG ++ LH A N + A +LL N +P
Sbjct: 163 LINYGT----KGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Score = 35.0 bits (79), Expect = 0.69
Identities = 35/148 (23%), Positives = 57/148 (38%), Gaps = 1/148 (0%)
Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
S N N+ E ++ AA ++ + ++ VN + T LH A+ G
Sbjct: 429 SPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488
Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM 600
LL+ A+ N+ TPLH A GH + LL A G L A
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK 548
Query: 601 KRLLERYIPKHQKCLTSAQRSSIDPLDI 628
R+ E + + +A ++ + PL +
Sbjct: 549 VRVAELLLERDAH-PNAAGKNGLTPLHV 575
Score = 34.7 bits (78), Expect = 0.90
Identities = 28/114 (24%), Positives = 49/114 (42%), Gaps = 3/114 (2%)
Query: 470 EKMKVNKISLH---SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTAL 526
E + V ++ L+ S+N G ++ A+ + +V + +G + + T L
Sbjct: 217 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276
Query: 527 HEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGAD 580
H A+ G R + LL GA + K ++P+H A H LLL A+
Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
Score = 34.7 bits (78), Expect = 0.90
Identities = 24/86 (27%), Positives = 41/86 (47%)
Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
G ++ A+ + + LV ++ +VN + G++ LH+A+ G + LLK GA
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 549 NIKGLYQITPLHDAVMNGHYKVAELL 574
N TPL A G+ V ++L
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 79.3 bits (194), Expect = 3e-14
Identities = 55/171 (32%), Positives = 94/171 (54%), Gaps = 6/171 (3%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
++ ++ G + L +A +GN+ +V+ L++ G D N D+AGWTPLH A+ EG I L
Sbjct: 807 VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEAL 866
Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDE--- 1264
++ GA+ N + DG +P A H +ILL+N +N +Q+ ++AL A E
Sbjct: 867 IEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHR 926
Query: 1265 KMKELLRSYGAIETVNRDESDAIVNEKIPAVRSK-RHKQCFCDDGKTIDSS 1314
+ ELL S+GA VN ++D I A+ ++ + F ++G +++S
Sbjct: 927 DIVELLFSHGA--DVNCKDADGRPTLYILALENQLTMAEYFLENGANVEAS 975
Score = 73.6 bits (179), Expect = 2e-12
Identities = 48/137 (35%), Positives = 71/137 (51%), Gaps = 5/137 (3%)
Query: 1152 NARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAG 1211
+A G + L LA R+G+ +V LI GA++N D GWT L A+ G +++ LL AG
Sbjct: 575 DAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAG 634
Query: 1212 AKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA---DDEKMKE 1268
KV+C + D L A H LLQ+GA N+ D + ++AL A ++ E
Sbjct: 635 VKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVE 694
Query: 1269 LLRSYGAIETVNRDESD 1285
L +GA VN ++ D
Sbjct: 695 HLLDHGA--EVNHEDVD 709
Score = 67.4 bits (163), Expect = 1e-10
Identities = 40/131 (30%), Positives = 71/131 (54%), Gaps = 3/131 (2%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
+ +A G + LH++ +G++ +V+ LI ADVN DN + L A+ +G + ++ L
Sbjct: 972 VEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLL 1031
Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA---DDE 1264
++ GA V+ G L A H+ ++LL++GA+PN DQ ++A+ A
Sbjct: 1032 IEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHS 1091
Query: 1265 KMKELLRSYGA 1275
++ +LL YGA
Sbjct: 1092 QIIKLLEKYGA 1102
Score = 61.6 bits (148), Expect = 7e-09
Identities = 58/185 (31%), Positives = 81/185 (43%), Gaps = 43/185 (23%)
Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI----- 1203
N R+ G + LH+A G+ + +ALIE GA N DN G P AS EG D
Sbjct: 841 NHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILL 900
Query: 1204 ---------------------------IVELLKA-GAKVNCENIDGILPLHDAVANNHLK 1235
IVELL + GA VNC++ DG L+ N L
Sbjct: 901 ENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLT 960
Query: 1236 AAEILLQNGANPNQKDQKQKSALDEA---DDEKMKELLRSYGAIETVNRDESDAIVNEKI 1292
AE L+NGAN D + ++AL + +M ++L +Y A + +A NEK
Sbjct: 961 MAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHA-------DVNAADNEKR 1013
Query: 1293 PAVRS 1297
A++S
Sbjct: 1014 SALQS 1018
Score = 60.8 bits (146), Expect = 1e-08
Identities = 38/132 (28%), Positives = 66/132 (50%), Gaps = 3/132 (2%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
I++R G + L +A G+ +V+ L GADVN D G L+ + E + +
Sbjct: 906 IDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYF 965
Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA---DDE 1264
L+ GA V + +G LH + H++ ++L+ A+ N D +++SAL A
Sbjct: 966 LENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHV 1025
Query: 1265 KMKELLRSYGAI 1276
K+ +LL +GA+
Sbjct: 1026 KVVQLLIEHGAV 1037
Score = 60.5 bits (145), Expect = 2e-08
Identities = 46/167 (27%), Positives = 80/167 (47%), Gaps = 3/167 (1%)
Query: 1109 HNIDSHSTDNMSKE-LANISKLSQREKKE--ISHKPGMKAGRINKRNARGESQLHLAVRR 1165
H + + DN + L + + RE E + H + ++ R A + L + +
Sbjct: 666 HGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASK 725
Query: 1166 GNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPL 1225
G+ +V LI+ GA+V+ D G TPL A+ EG +D++ LL+ GA V+ + +G PL
Sbjct: 726 GHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPL 785
Query: 1226 HDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELLRS 1272
A + H LL GA + D + ++ L A + E++R+
Sbjct: 786 LAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRT 832
Score = 58.2 bits (139), Expect = 8e-08
Identities = 40/120 (33%), Positives = 61/120 (50%), Gaps = 3/120 (2%)
Query: 1143 MKAG-RINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSI 1201
+KAG +N + R + A+ R + ++ L+++GA VN D+ G T L A+ GS+
Sbjct: 501 VKAGAHVNSEDDRTSCIVRQALEREDS--IRTLLDNGASVNQCDSNGRTLLANAAYSGSL 558
Query: 1202 DIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
D++ L+ GA + E+ G PL A H K L+ GAN N DQ +AL A
Sbjct: 559 DVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSA 618
Score = 57.4 bits (137), Expect = 1e-07
Identities = 34/114 (29%), Positives = 55/114 (48%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
+N+ ++ G + L A G+L +V L+ GAD+ + D G TPL A+ +G ++ L
Sbjct: 538 VNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCL 597
Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
+ GA +N + DG L A H + LL G + D ++AL A
Sbjct: 598 IGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAA 651
Score = 56.2 bits (134), Expect = 3e-07
Identities = 40/154 (25%), Positives = 66/154 (42%)
Query: 455 NGKQIRKNEQFSGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGN 514
NG+ + N +SG + + + + + G + AA +V+ I G N
Sbjct: 544 NGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGAN 603
Query: 515 VNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELL 574
+N GWTAL A+ GG S LL G V+ T L A GH + L
Sbjct: 604 INHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNL 663
Query: 575 LLNGADPLFRNDDGKCALDEAKDLCMKRLLERYI 608
L +GA+ +++G+ AL A + + ++E +
Sbjct: 664 LQHGAEVNKADNEGRTALIAAAYMGHREIVEHLL 697
Score = 54.7 bits (130), Expect = 8e-07
Identities = 33/97 (34%), Positives = 52/97 (53%)
Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
G + L +A G++ +V L+E GADV+ DN G TPL A++ G ++ LL GA V
Sbjct: 748 GMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAV 807
Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKD 1251
+ + +G L A A +++ LL G + N +D
Sbjct: 808 DSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRD 844
Score = 51.2 bits (121), Expect = 9e-06
Identities = 34/111 (30%), Positives = 55/111 (49%), Gaps = 5/111 (4%)
Query: 1147 RINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVE 1206
+++ +A + L A G+ +V L++ GA+VN DN G T L A+ G +I+
Sbjct: 636 KVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEH 695
Query: 1207 LLKAGAKVNCENIDGILPLHDA-----VANNHLKAAEILLQNGANPNQKDQ 1252
LL GA+VN E++DG L A + H +L+ GA + D+
Sbjct: 696 LLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDK 746
Score = 49.7 bits (117), Expect = 3e-05
Identities = 33/99 (33%), Positives = 52/99 (52%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
+N + S L A +G++ +V+ LIE GA V+ N G T L A+ EG ID++ L
Sbjct: 1005 VNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVL 1064
Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGAN 1246
L+ GA N + G + A N H + ++L + GA+
Sbjct: 1065 LEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS 1103
Score = 47.8 bits (112), Expect = 1e-04
Identities = 29/98 (29%), Positives = 45/98 (45%)
Query: 482 INRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASEL 541
+N ++ G +Y AL + + + ++ G NV G TALH + G L
Sbjct: 939 VNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL 998
Query: 542 LKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579
+ ADVN + + L A GH KV +LL+ +GA
Sbjct: 999 IAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGA 1036
Score = 45.4 bits (106), Expect = 5e-04
Identities = 31/93 (33%), Positives = 43/93 (46%)
Query: 503 DLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDA 562
D + + G +VNQ G T L A+ G + L+ GAD+ I+ + TPL A
Sbjct: 526 DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLA 585
Query: 563 VMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
GH KV L+ GA+ + DG AL A
Sbjct: 586 ARQGHTKVVNCLIGCGANINHTDQDGWTALRSA 618
Score = 42.7 bits (99), Expect = 0.003
Identities = 30/115 (26%), Positives = 51/115 (44%)
Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
+I++R G N + AAL D+V G +VN G L+ ++ A
Sbjct: 905 NIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEY 964
Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
L+ GA+V T LH + GH ++ ++L+ AD +++ + AL A
Sbjct: 965 FLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSA 1019
Score = 40.8 bits (94), Expect = 0.013
Identities = 37/121 (30%), Positives = 50/121 (41%), Gaps = 4/121 (3%)
Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
G + AA A +V+ + G V+ G T L AS G LL G D
Sbjct: 781 GRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDE 840
Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGK----CALDEAKDLCMKRLL 604
N + TPLH A GH + E L+ GA ++DG+ A E C++ LL
Sbjct: 841 NHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILL 900
Query: 605 E 605
E
Sbjct: 901 E 901
Score = 40.0 bits (92), Expect = 0.021
Identities = 29/110 (26%), Positives = 48/110 (43%)
Query: 483 NRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELL 542
N R+ G ++ AA + I++G N+ G AS G Y LL
Sbjct: 841 NHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILL 900
Query: 543 KGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCAL 592
+ ++++ +G L A + GH + ELL +GAD ++ DG+ L
Sbjct: 901 ENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTL 950
Score = 39.7 bits (91), Expect = 0.028
Identities = 31/115 (26%), Positives = 50/115 (43%)
Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
S+N+ + G L+ AA D+V+ + +G ++ G T L A+ G + +
Sbjct: 537 SVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNC 596
Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
L+ GA++N T L A GH +V LL G + D + AL A
Sbjct: 597 LIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAA 651
Score = 39.7 bits (91), Expect = 0.028
Identities = 36/119 (30%), Positives = 49/119 (41%), Gaps = 5/119 (4%)
Query: 482 INRRNIFGENLVYKAAL-----HDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYR 536
+N ++ G + AAL A +V I +G V+ G T L A+ G
Sbjct: 703 VNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVD 762
Query: 537 TASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
LL+GGADV+ TPL A GH V LL GA + +G+ L A
Sbjct: 763 VVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIA 821
Score = 39.7 bits (91), Expect = 0.028
Identities = 27/90 (30%), Positives = 40/90 (44%)
Query: 503 DLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDA 562
D V ++ N++Q Y G AL A++ G L GADVN K L+
Sbjct: 894 DCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYIL 953
Query: 563 VMNGHYKVAELLLLNGADPLFRNDDGKCAL 592
+ +AE L NGA+ + +G+ AL
Sbjct: 954 ALENQLTMAEYFLENGANVEASDAEGRTAL 983
Score = 37.4 bits (85), Expect = 0.14
Identities = 41/159 (25%), Positives = 66/159 (41%), Gaps = 14/159 (8%)
Query: 437 PALMIDGKEKNMHSARF--KNGKQIRKNEQ----------FSGKKEKMKVNKISLHS-IN 483
P L I E + A + +NG + ++ + G E ++V I+ H+ +N
Sbjct: 948 PTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQV-LIAYHADVN 1006
Query: 484 RRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLK 543
+ + + AA +V I+ G V+ G TAL A+ G LL+
Sbjct: 1007 AADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLE 1066
Query: 544 GGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPL 582
GAD N + T + A NGH ++ +LL GA L
Sbjct: 1067 HGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSL 1105
Score = 31.2 bits (69), Expect = 9.9
Identities = 28/93 (30%), Positives = 39/93 (41%)
Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
AA D+V ++ G +V+ G T L A+ G + LL GA V+
Sbjct: 755 AAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEG 814
Query: 556 ITPLHDAVMNGHYKVAELLLLNGADPLFRNDDG 588
T L A G+ +V LL G D R+D G
Sbjct: 815 RTVLSIASAQGNVEVVRTLLDRGLDENHRDDAG 847
>gi|33286442 BCL6 co-repressor-like 1 [Homo sapiens]
Length = 1711
Score = 79.0 bits (193), Expect = 4e-14
Identities = 42/100 (42%), Positives = 58/100 (58%)
Query: 1174 LIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNH 1233
L + DVN DNAG+T LHEA + G DI+ LL+ GA VNC DG P+HDAV N++
Sbjct: 1442 LQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDN 1501
Query: 1234 LKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELLRSY 1273
L+ +LL GA+P ++A+ A + MK L +
Sbjct: 1502 LETIWLLLSYGADPTLATYSGQTAMKLASSDTMKRFLSDH 1541
Score = 67.4 bits (163), Expect = 1e-10
Identities = 43/117 (36%), Positives = 65/117 (55%), Gaps = 2/117 (1%)
Query: 494 YKAALHDDA-DLVHHCIKKGG-NVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIK 551
+ A + ++A D+V +C++K +VN AG+TALHEA G+ + LL+ GA+VN
Sbjct: 1426 HMATVSEEAKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCS 1485
Query: 552 GLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCMKRLLERYI 608
P+HDAV+N + + LLL GADP G+ A+ A MKR L ++
Sbjct: 1486 AQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDTMKRFLSDHL 1542
Score = 32.3 bits (72), Expect = 4.5
Identities = 27/87 (31%), Positives = 39/87 (44%), Gaps = 3/87 (3%)
Query: 1196 SNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQK 1255
S E ++ L K VN + G LH+A + ILL++GAN N Q
Sbjct: 1431 SEEAKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGT 1490
Query: 1256 SALDEA---DDEKMKELLRSYGAIETV 1279
+ +A D+ + LL SYGA T+
Sbjct: 1491 RPVHDAVVNDNLETIWLLLSYGADPTL 1517
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 77.8 bits (190), Expect = 9e-14
Identities = 55/182 (30%), Positives = 90/182 (49%), Gaps = 5/182 (2%)
Query: 1103 LESETIHNIDSHSTDNMSKELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHLA 1162
L E H ++ + TD + E A ++ + R K E+ +++ N RG L A
Sbjct: 1053 LGMEKEHEVEVNGTDTLWGETA-LTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCA 1111
Query: 1163 VRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGI 1222
R+G+ +V+ L+E G DVNL+D G TPL A+ EG + + LL GA ++ + +G+
Sbjct: 1112 ARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGL 1171
Query: 1223 LPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA----DDEKMKELLRSYGAIET 1278
L A H + L++ GA +Q D+ ++ LD A D E + L+ IE
Sbjct: 1172 SALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEH 1231
Query: 1279 VN 1280
V+
Sbjct: 1232 VD 1233
Score = 48.5 bits (114), Expect = 6e-05
Identities = 29/102 (28%), Positives = 51/102 (50%)
Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
K ++ + G S L A +G+ +V+ L+E GA ++ D G TPL A+ G +
Sbjct: 1159 KGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAET 1218
Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGA 1245
++ L++ GA + + G+ PL A+ + LL+ GA
Sbjct: 1219 VLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
Score = 47.8 bits (112), Expect = 1e-04
Identities = 39/148 (26%), Positives = 64/148 (43%), Gaps = 5/148 (3%)
Query: 487 IFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGA 546
++GE + AA ++ + G V++ + G L A+ G ++ LL+ G
Sbjct: 1069 LWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGC 1128
Query: 547 DVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCMK--RLL 604
DVN+ TPL A GH E LL GA + +G AL A C+K R +
Sbjct: 1129 DVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA---CLKGHRAV 1185
Query: 605 ERYIPKHQKCLTSAQRSSIDPLDIEDVY 632
+Y+ + + ++ PLD+ Y
Sbjct: 1186 VQYLVEEGAAIDQTDKNGRTPLDLAAFY 1213
Score = 38.9 bits (89), Expect = 0.048
Identities = 22/67 (32%), Positives = 36/67 (53%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
I++ + G + L LA G+ V L+E GA + D++G PL A + ++V L
Sbjct: 1196 IDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVAL 1255
Query: 1208 LKAGAKV 1214
L+ GAK+
Sbjct: 1256 LRKGAKL 1262
Score = 33.1 bits (74), Expect = 2.6
Identities = 26/94 (27%), Positives = 46/94 (48%), Gaps = 2/94 (2%)
Query: 1167 NLPLVKALIESGADVNLNDNA--GWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILP 1224
N+ + + LI GA+VN L S+ G +++ LL+ GA ++ + +G+
Sbjct: 904 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
Query: 1225 LHDAVANNHLKAAEILLQNGANPNQKDQKQKSAL 1258
L A A H+K +L + G + D+K + AL
Sbjct: 964 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 997
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 77.8 bits (190), Expect = 9e-14
Identities = 55/182 (30%), Positives = 90/182 (49%), Gaps = 5/182 (2%)
Query: 1103 LESETIHNIDSHSTDNMSKELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHLA 1162
L E H ++ + TD + E A ++ + R K E+ +++ N RG L A
Sbjct: 1061 LGMEKEHEVEVNGTDTLWGETA-LTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCA 1119
Query: 1163 VRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGI 1222
R+G+ +V+ L+E G DVNL+D G TPL A+ EG + + LL GA ++ + +G+
Sbjct: 1120 ARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGL 1179
Query: 1223 LPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA----DDEKMKELLRSYGAIET 1278
L A H + L++ GA +Q D+ ++ LD A D E + L+ IE
Sbjct: 1180 SALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEH 1239
Query: 1279 VN 1280
V+
Sbjct: 1240 VD 1241
Score = 48.5 bits (114), Expect = 6e-05
Identities = 29/102 (28%), Positives = 51/102 (50%)
Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
K ++ + G S L A +G+ +V+ L+E GA ++ D G TPL A+ G +
Sbjct: 1167 KGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAET 1226
Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGA 1245
++ L++ GA + + G+ PL A+ + LL+ GA
Sbjct: 1227 VLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
Score = 47.8 bits (112), Expect = 1e-04
Identities = 39/148 (26%), Positives = 64/148 (43%), Gaps = 5/148 (3%)
Query: 487 IFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGA 546
++GE + AA ++ + G V++ + G L A+ G ++ LL+ G
Sbjct: 1077 LWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGC 1136
Query: 547 DVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCMK--RLL 604
DVN+ TPL A GH E LL GA + +G AL A C+K R +
Sbjct: 1137 DVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA---CLKGHRAV 1193
Query: 605 ERYIPKHQKCLTSAQRSSIDPLDIEDVY 632
+Y+ + + ++ PLD+ Y
Sbjct: 1194 VQYLVEEGAAIDQTDKNGRTPLDLAAFY 1221
Score = 38.9 bits (89), Expect = 0.048
Identities = 22/67 (32%), Positives = 36/67 (53%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
I++ + G + L LA G+ V L+E GA + D++G PL A + ++V L
Sbjct: 1204 IDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVAL 1263
Query: 1208 LKAGAKV 1214
L+ GAK+
Sbjct: 1264 LRKGAKL 1270
Score = 33.1 bits (74), Expect = 2.6
Identities = 26/94 (27%), Positives = 46/94 (48%), Gaps = 2/94 (2%)
Query: 1167 NLPLVKALIESGADVNLNDNA--GWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILP 1224
N+ + + LI GA+VN L S+ G +++ LL+ GA ++ + +G+
Sbjct: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
Query: 1225 LHDAVANNHLKAAEILLQNGANPNQKDQKQKSAL 1258
L A A H+K +L + G + D+K + AL
Sbjct: 972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 1005
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 77.8 bits (190), Expect = 9e-14
Identities = 40/111 (36%), Positives = 59/111 (53%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
+N N G + LHLA + + + + L+ GA V+ G+TPLH + G+I I+ L
Sbjct: 690 VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFL 749
Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSAL 1258
L+ AKVN + +G PLH A H +LLQN A+PN+ +AL
Sbjct: 750 LQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTAL 800
Score = 75.1 bits (183), Expect = 6e-13
Identities = 49/177 (27%), Positives = 88/177 (49%), Gaps = 4/177 (2%)
Query: 1102 HLESETIHNIDSHSTDNMSKELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHL 1161
++ S+ +H+ S +T N+ E A + ++ + E+ ++ + ++ LH+
Sbjct: 447 NIVSQLMHHGASPNTTNVRGETA-LHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHI 505
Query: 1162 AVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDG 1221
+ R G +V+ L++ GA N +G+TPLH ++ EG D+ LL GA ++ G
Sbjct: 506 SARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKG 565
Query: 1222 ILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA---DDEKMKELLRSYGA 1275
PLH A L+ A +LLQ A+P+ + + L A D++K+ LL GA
Sbjct: 566 FTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGA 622
Score = 73.6 bits (179), Expect = 2e-12
Identities = 44/132 (33%), Positives = 62/132 (46%), Gaps = 9/132 (6%)
Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
N N RGE+ LH+A R G +V+ L++ GA V TPLH ++ G DI+ +LL
Sbjct: 460 NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLL 519
Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKE 1268
+ GA N G PLH + H A LL +GA+ + +K + L A
Sbjct: 520 QQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVA------- 572
Query: 1269 LLRSYGAIETVN 1280
YG +E N
Sbjct: 573 --AKYGKLEVAN 582
Score = 70.9 bits (172), Expect = 1e-11
Identities = 54/167 (32%), Positives = 80/167 (47%), Gaps = 10/167 (5%)
Query: 1085 AHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSKELANISKL-----SQREKKEISH 1139
A SQ+ + +E + E + H S D K AN S L EK
Sbjct: 4 AASQLKKNRDLEINAEEEPEKKRKHR--KRSRDRKKKSDANASYLRAARAGHLEKALDYI 61
Query: 1140 KPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEG 1199
K G+ IN N G + LHLA + G++ +V L++ A+V+ G T LH AS G
Sbjct: 62 KNGVD---INICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAG 118
Query: 1200 SIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGAN 1246
+++ L+ GA VN ++ +G PL+ A NHL+ + LL NGA+
Sbjct: 119 QAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS 165
Score = 67.4 bits (163), Expect = 1e-10
Identities = 36/113 (31%), Positives = 61/113 (53%)
Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
N +G + +HLA + G++ +V L+ A+VNL++ +G TPLH A+ E +++ L+
Sbjct: 658 NAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLV 717
Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
GA V+ + G PLH ++K LLQ+ A N K + + L +A
Sbjct: 718 NQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA 770
Score = 66.2 bits (160), Expect = 3e-10
Identities = 55/223 (24%), Positives = 96/223 (43%), Gaps = 8/223 (3%)
Query: 1052 HIVEKMAKNCDTERNYIDRDQKIIYSNEPLSIVAHSQVIETTKVEKRRQNHLESETIHNI 1111
H ++ KN D E N + +K + + + R HLE +
Sbjct: 3 HAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIK 62
Query: 1112 DSHSTDNMSKELANISKLSQREKK-EISHKPGMKAGRINKRNARGESQLHLAVRRGNLPL 1170
+ + ++ N L+ +E E+ + + ++ +G + LH+A G +
Sbjct: 63 NGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEV 122
Query: 1171 VKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVA 1230
VK L+ +GA+VN G+TPL+ A+ E ++++ LL GA + DG PL A+
Sbjct: 123 VKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQ 182
Query: 1231 NNHLKAAEILLQNGANPNQKDQKQKSALDEA---DDEKMKELL 1270
H + +LL+N + K + + AL A DD K LL
Sbjct: 183 QGHDQVVSLLLEN----DTKGKVRLPALHIAARKDDTKAAALL 221
Score = 66.2 bits (160), Expect = 3e-10
Identities = 32/92 (34%), Positives = 50/92 (54%)
Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
G + LH+A ++ + + L+E GAD N G +H A+ EG +D++ LL A V
Sbjct: 631 GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANV 690
Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNGAN 1246
N N G+ PLH A + + AE+L+ GA+
Sbjct: 691 NLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAH 722
Score = 64.7 bits (156), Expect = 8e-10
Identities = 42/159 (26%), Positives = 73/159 (45%), Gaps = 3/159 (1%)
Query: 1113 SHSTDNMSKELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVK 1172
+H+ + K + +K+ H+ K R K+ + + A R G+L
Sbjct: 2 AHAASQLKKNRDLEINAEEEPEKKRKHR---KRSRDRKKKSDANASYLRAARAGHLEKAL 58
Query: 1173 ALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANN 1232
I++G D+N+ + G LH AS EG ++++ ELL+ A V+ G LH A
Sbjct: 59 DYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAG 118
Query: 1233 HLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELLR 1271
+ ++L+ NGAN N + Q + L A E E+++
Sbjct: 119 QAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVK 157
Score = 64.7 bits (156), Expect = 8e-10
Identities = 41/150 (27%), Positives = 74/150 (49%), Gaps = 10/150 (6%)
Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
N G + LHL+ R G+ + L++ GA +++ G+TPLH A+ G +++ LL
Sbjct: 526 NAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLL 585
Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKE 1268
+ A + G+ PLH A ++ K A +LL GA+P+ + + L A + +
Sbjct: 586 QKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMD 645
Query: 1269 L---LRSYGAIETVNRDESDAIVNEKIPAV 1295
+ L YGA +++A+ + I +V
Sbjct: 646 IATTLLEYGA-------DANAVTRQGIASV 668
Score = 63.9 bits (154), Expect = 1e-09
Identities = 35/113 (30%), Positives = 58/113 (51%)
Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
LH+A G+ + K L++ A+ N G+TPLH A + I ++ LLK GA +
Sbjct: 371 LHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT 430
Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELLR 1271
G+ P+H A H+ L+ +GA+PN + + ++AL A E++R
Sbjct: 431 ESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVR 483
Score = 62.0 bits (149), Expect = 5e-09
Identities = 30/85 (35%), Positives = 48/85 (56%)
Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
LH+A +RGN +VK L++ GA ++ G TPLH + G ++ LL A + +
Sbjct: 272 LHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKT 331
Query: 1219 IDGILPLHDAVANNHLKAAEILLQN 1243
+G+ PLH A +HL ++LLQ+
Sbjct: 332 KNGLSPLHMATQGDHLNCVQLLLQH 356
Score = 61.6 bits (148), Expect = 7e-09
Identities = 39/118 (33%), Positives = 57/118 (48%), Gaps = 5/118 (4%)
Query: 1149 NKRNARGESQ-----LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
N NA ES+ LH+A GN+ + L+ A V+ TPLH AS G+ ++
Sbjct: 224 NDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANM 283
Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
+ LL GAK++ + DG+ PLH + H + E+LL A K + S L A
Sbjct: 284 VKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMA 341
Score = 61.6 bits (148), Expect = 7e-09
Identities = 31/115 (26%), Positives = 59/115 (51%)
Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
K N + G + LH+A ++ + +++ L++ GA + +G TP+H A+ G ++I
Sbjct: 389 KKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNI 448
Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSAL 1258
+ +L+ GA N N+ G LH A + + L+Q+GA K + ++ L
Sbjct: 449 VSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPL 503
Score = 60.5 bits (145), Expect = 2e-08
Identities = 41/128 (32%), Positives = 61/128 (47%), Gaps = 4/128 (3%)
Query: 482 INRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASEL 541
IN N G N ++ A+ ++V +++ NV+ + G TALH AS+ G L
Sbjct: 67 INICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVL 126
Query: 542 LKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDG----KCALDEAKD 597
+ GA+VN + TPL+ A H +V + LL NGA +DG AL + D
Sbjct: 127 VTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHD 186
Query: 598 LCMKRLLE 605
+ LLE
Sbjct: 187 QVVSLLLE 194
Score = 59.7 bits (143), Expect = 3e-08
Identities = 41/145 (28%), Positives = 66/145 (45%), Gaps = 3/145 (2%)
Query: 1134 KKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLH 1193
K E+++ K+ + G + LH+A N + L++ GA + G+TPLH
Sbjct: 577 KLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLH 636
Query: 1194 EASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQK 1253
A+ + +DI LL+ GA N GI +H A H+ +LL AN N ++
Sbjct: 637 IAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKS 696
Query: 1254 QKSALDEADDE---KMKELLRSYGA 1275
+ L A E + E+L + GA
Sbjct: 697 GLTPLHLAAQEDRVNVAEVLVNQGA 721
Score = 55.5 bits (132), Expect = 5e-07
Identities = 36/118 (30%), Positives = 55/118 (46%)
Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
++N N G ++ AA D ++ + +G +V+ + G+T LH G + +
Sbjct: 689 NVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNF 748
Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDL 598
LL+ A VN K TPLH A GH + +LL N A P +G AL A+ L
Sbjct: 749 LLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRL 806
Score = 54.7 bits (130), Expect = 8e-07
Identities = 33/103 (32%), Positives = 53/103 (51%)
Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
+A I + G S LH+A + +L V+ L++ V+ N T LH A++ G +
Sbjct: 323 RAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKV 382
Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGAN 1246
LL A N + ++G PLH A N +K E+LL++GA+
Sbjct: 383 AKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGAS 425
Score = 54.7 bits (130), Expect = 8e-07
Identities = 30/94 (31%), Positives = 49/94 (52%)
Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
G + +H+A G++ +V L+ GA N + G T LH A+ G +++ L++ GA+V
Sbjct: 433 GLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQV 492
Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
+ D PLH + + LLQ GA+PN
Sbjct: 493 EAKAKDDQTPLHISARLGKADIVQQLLQQGASPN 526
Score = 53.9 bits (128), Expect = 1e-06
Identities = 59/247 (23%), Positives = 99/247 (40%), Gaps = 25/247 (10%)
Query: 1118 NMSKELANISKLS------QREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLV 1171
N + L+N S L+ Q ++ ++ + ++ + G + LH+ GN+ +V
Sbjct: 687 NANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIV 746
Query: 1172 KALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVAN 1231
L++ A VN G+TPLH+A+ +G II LL+ A N ++G L A
Sbjct: 747 NFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRL 806
Query: 1232 NHLKAAE---ILLQNGANPNQKDQKQK--------SALDEADDEKMKELLRSYGAIETVN 1280
++ + I+ + +K K LD +DDE +R A E ++
Sbjct: 807 GYISVVDTLKIVTEETMTTTTVTEKHKMNVPETMNEVLDMSDDE-----VRKANAPEMLS 861
Query: 1281 RDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQERSRESLSVHQTLSAILQDIE 1340
E + V E A+ K D K + SL + SL SA L+
Sbjct: 862 DGEYISDVEEGEDAMTGDTDKYLGPQDLKELGDDSLPAEGYMGFSLGAR---SASLRSFS 918
Query: 1341 EKQEYLL 1347
+ Y L
Sbjct: 919 SDRSYTL 925
Score = 51.6 bits (122), Expect = 7e-06
Identities = 27/92 (29%), Positives = 49/92 (53%)
Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
LH+A R+ + L+++ + ++ +G+TPLH A++ G+I++ LL A V+
Sbjct: 206 LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTA 265
Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQK 1250
+ I PLH A + ++LL GA + K
Sbjct: 266 RNDITPLHVASKRGNANMVKLLLDRGAKIDAK 297
Score = 51.2 bits (121), Expect = 9e-06
Identities = 42/156 (26%), Positives = 65/156 (41%), Gaps = 1/156 (0%)
Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
S N N+ GE ++ AA A++V + ++ G V + T LH ++ G +
Sbjct: 458 SPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQ 517
Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM 600
LL+ GA N TPLH + GH VA LL +GA G L A
Sbjct: 518 LLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGK 577
Query: 601 KRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKK 636
+ + K +A +S + PL + Y ++K
Sbjct: 578 LEVANLLLQK-SASPDAAGKSGLTPLHVAAHYDNQK 612
Score = 48.5 bits (114), Expect = 6e-05
Identities = 40/143 (27%), Positives = 61/143 (42%), Gaps = 9/143 (6%)
Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
AA DD ++ N + S +G+T LH A+ G A+ LL A V+
Sbjct: 209 AARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND 268
Query: 556 ITPLHDAVMNGHYKVAELLLLNGADPLFRNDDG----KCALDEAKDLCMKRLLERYIPKH 611
ITPLH A G+ + +LLL GA + DG C + ++ LL+R P
Sbjct: 269 ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAP-- 326
Query: 612 QKCLTSAQRSSIDPLDIEDVYQH 634
+ S ++ + PL + H
Sbjct: 327 ---ILSKTKNGLSPLHMATQGDH 346
Score = 47.8 bits (112), Expect = 1e-04
Identities = 40/134 (29%), Positives = 65/134 (48%), Gaps = 3/134 (2%)
Query: 458 QIRKNE--QFSGKKEKMKVNKISLHSINRRNIFGENLVY-KAALHDDADLVHHCIKKGGN 514
Q++KN + + ++E K K S +R+ N Y +AA + IK G +
Sbjct: 7 QLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVD 66
Query: 515 VNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELL 574
+N + G ALH AS G SELL+ A+V+ T LH A + G +V ++L
Sbjct: 67 INICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVL 126
Query: 575 LLNGADPLFRNDDG 588
+ NGA+ ++ +G
Sbjct: 127 VTNGANVNAQSQNG 140
Score = 47.4 bits (111), Expect = 1e-04
Identities = 34/107 (31%), Positives = 46/107 (42%), Gaps = 5/107 (4%)
Query: 494 YKAALHDDADLVHH-----CIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
Y ALH A H+ + K N N + G+T LH A + LLK GA +
Sbjct: 367 YLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASI 426
Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
+TP+H A GH + L+ +GA P N G+ AL A
Sbjct: 427 QAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMA 473
Score = 47.4 bits (111), Expect = 1e-04
Identities = 35/117 (29%), Positives = 52/117 (44%), Gaps = 3/117 (2%)
Query: 468 KKEKMKVNKISLH---SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWT 524
KK ++KV ++ L SI G ++ AA ++V + G + N + G T
Sbjct: 409 KKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGET 468
Query: 525 ALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
ALH A+ G L++ GA V K TPLH + G + + LL GA P
Sbjct: 469 ALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASP 525
Score = 45.1 bits (105), Expect = 7e-04
Identities = 29/89 (32%), Positives = 42/89 (47%)
Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
G ++ A+L A++V + G NVN S G+T L+ A+ LL GA
Sbjct: 107 GNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQ 166
Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLN 577
++ TPL A+ GH +V LLL N
Sbjct: 167 SLATEDGFTPLAVALQQGHDQVVSLLLEN 195
Score = 44.3 bits (103), Expect = 0.001
Identities = 45/173 (26%), Positives = 75/173 (43%), Gaps = 13/173 (7%)
Query: 429 AQNFRMQDPALMIDGKEKNMHSARFKNGKQIRKNEQFSGKKEKMKVNKISL------HSI 482
A ++ Q AL++ + + H+A KNG + KK +M + L +++
Sbjct: 605 AAHYDNQKVALLLLDQGASPHAAA-KNGYTPL---HIAAKKNQMDIATTLLEYGADANAV 660
Query: 483 NRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELL 542
R+ I V+ AA D+V + + NVN + +G T LH A+ A L+
Sbjct: 661 TRQGIAS---VHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLV 717
Query: 543 KGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
GA V+ + TPLH G+ K+ LL + A + +G L +A
Sbjct: 718 NQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA 770
Score = 43.1 bits (100), Expect = 0.003
Identities = 31/101 (30%), Positives = 47/101 (46%)
Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
S N G ++ +A D+ + G +++ + G+T LH A+ G A+
Sbjct: 524 SPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANL 583
Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
LL+ A + G +TPLH A + KVA LLL GA P
Sbjct: 584 LLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASP 624
Score = 39.3 bits (90), Expect = 0.036
Identities = 27/96 (28%), Positives = 44/96 (45%)
Query: 493 VYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKG 552
++ AA +D+ + + +G + + + G+T LH A+ A+ LL+ GAD N
Sbjct: 602 LHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVT 661
Query: 553 LYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDG 588
I +H A GH + LLL A+ N G
Sbjct: 662 RQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSG 697
Score = 37.7 bits (86), Expect = 0.11
Identities = 32/115 (27%), Positives = 50/115 (43%), Gaps = 5/115 (4%)
Query: 522 GWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
G + LH A+ G LL+ V+ +T LH A GHYKVA++LL A+P
Sbjct: 334 GLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANP 393
Query: 582 LFRNDDGKCALDEAKDLCMKRLLE--RYIPKHQKCLTSAQRSSIDPLDIEDVYQH 634
+ +G L A C K ++ + KH + + S + P+ + H
Sbjct: 394 NAKALNGFTPLHIA---CKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGH 445
Score = 35.0 bits (79), Expect = 0.69
Identities = 21/83 (25%), Positives = 38/83 (45%)
Query: 493 VYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKG 552
++ A+ +A++V + +G ++ + G T LH + G + LL A + K
Sbjct: 272 LHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKT 331
Query: 553 LYQITPLHDAVMNGHYKVAELLL 575
++PLH A H +LLL
Sbjct: 332 KNGLSPLHMATQGDHLNCVQLLL 354
Score = 33.5 bits (75), Expect = 2.0
Identities = 24/88 (27%), Positives = 39/88 (44%)
Query: 493 VYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKG 552
++ AA + ++ + ++K + + +G T LH A+ + A LL GA +
Sbjct: 569 LHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAA 628
Query: 553 LYQITPLHDAVMNGHYKVAELLLLNGAD 580
TPLH A +A LL GAD
Sbjct: 629 KNGYTPLHIAAKKNQMDIATTLLEYGAD 656
>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
sapiens]
Length = 587
Score = 77.8 bits (190), Expect = 9e-14
Identities = 49/140 (35%), Positives = 72/140 (51%), Gaps = 5/140 (3%)
Query: 1152 NARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAG 1211
N E+ L+ A R N VK L++ AD N N GWT LHE+ + ++++ L+ G
Sbjct: 154 NKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGG 213
Query: 1212 AKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA---DDEKMKE 1268
AKV +N GI PL A + L+A L + GA+ N + SAL EA + E++ E
Sbjct: 214 AKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVE 273
Query: 1269 LLRSYGAIETVNRDESDAIV 1288
L S GA N+ D ++
Sbjct: 274 FLLSQGA--DANKTNKDGLL 291
Score = 63.9 bits (154), Expect = 1e-09
Identities = 35/104 (33%), Positives = 56/104 (53%)
Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
N R RG + LH +V R +L +++ L+ GA V + G TPL A+ G ++ + L
Sbjct: 184 NHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLA 243
Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQ 1252
K GA +N + D L++A N H + E LL GA+ N+ ++
Sbjct: 244 KYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNK 287
Score = 61.2 bits (147), Expect = 9e-09
Identities = 42/146 (28%), Positives = 77/146 (52%), Gaps = 4/146 (2%)
Query: 1146 GRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIV 1205
G I++R + E+ ++LA RG+L + +L+++GA+ ++++ + TPL++A + + +
Sbjct: 115 GTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVK 174
Query: 1206 ELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEK 1265
L++ A N G LH++V+ N L+ +IL+ GA K+ + L A
Sbjct: 175 ILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSG 234
Query: 1266 MKELLR---SYGA-IETVNRDESDAI 1287
E LR YGA I T D + A+
Sbjct: 235 QLEALRFLAKYGADINTQASDNASAL 260
Score = 58.2 bits (139), Expect = 8e-08
Identities = 48/178 (26%), Positives = 67/178 (37%), Gaps = 35/178 (19%)
Query: 490 ENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVN 549
E +YKA +A+ V ++ + N GWTALHE+ L+ GGA V
Sbjct: 158 ETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVE 217
Query: 550 IKGLYQITPL---------------------------------HDAVMNGHYKVAELLLL 576
K Y ITPL ++A N H +V E LL
Sbjct: 218 SKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLS 277
Query: 577 NGADPLFRNDDGKCALDEAKDLCMKRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQH 634
GAD N DG L A R+++ +P + T +RS + PL + H
Sbjct: 278 QGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSR--TRIRRSGVSPLHLAAERNH 333
Score = 56.2 bits (134), Expect = 3e-07
Identities = 30/95 (31%), Positives = 51/95 (53%)
Query: 1147 RINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVE 1206
++ +NA G + L +A + G L ++ L + GAD+N + + L+EA +++
Sbjct: 215 KVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEF 274
Query: 1207 LLKAGAKVNCENIDGILPLHDAVANNHLKAAEILL 1241
LL GA N N DG+LPLH A + + ++LL
Sbjct: 275 LLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLL 309
Score = 55.8 bits (133), Expect = 4e-07
Identities = 52/188 (27%), Positives = 84/188 (44%), Gaps = 22/188 (11%)
Query: 1071 DQKIIYSNEPLSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSKELANISKLS 1130
+ K Y PL + A S +E + + +I++ ++DN S L K
Sbjct: 217 ESKNAYGITPLFVAAQSGQLEALRFLAKYGA--------DINTQASDNASA-LYEACKNE 267
Query: 1131 QREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWT 1190
E E G A NK N G LH+A ++GN +V+ L+ + + +G +
Sbjct: 268 HEEVVEFLLSQGADA---NKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIR-RSGVS 323
Query: 1191 PLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHD---------AVANNHLKAAEILL 1241
PLH A+ +++ LL A VN L++ AV NN++ A E+LL
Sbjct: 324 PLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLL 383
Query: 1242 QNGANPNQ 1249
Q+GA+PN+
Sbjct: 384 QHGADPNR 391
Score = 55.1 bits (131), Expect = 6e-07
Identities = 53/185 (28%), Positives = 83/185 (44%), Gaps = 21/185 (11%)
Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
IN + + S L+ A + + +V+ L+ GAD N + G PLH AS +G+ I+ L
Sbjct: 249 INTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQML 308
Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQK---------DQKQKSAL 1258
L ++ G+ PLH A NH + E LL + N + ++ SAL
Sbjct: 309 LPVTSRTRIRR-SGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSAL 367
Query: 1259 DEA---DDEKMKELLRSYGAIETVNRDESDAIVNEKIPAVR--SKRHKQCFCDDGKTIDS 1313
A ++ ELL +GA NRD +++ + A+R R Q D G ID+
Sbjct: 368 YFAVVNNNVYATELLLQHGA--DPNRD----VISPLLVAIRHGCLRTMQLLLDHGANIDA 421
Query: 1314 SSLSH 1318
+H
Sbjct: 422 YIATH 426
Score = 49.7 bits (117), Expect = 3e-05
Identities = 39/157 (24%), Positives = 73/157 (46%), Gaps = 38/157 (24%)
Query: 1162 AVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASN------------------------ 1197
A++ G+ +K +I+ G ++ + GW PLHEA+
Sbjct: 64 AIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQ 123
Query: 1198 ----------EGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANP 1247
G +D ++ LL+AGA+ + N PL+ A + +A +IL+Q+ A+
Sbjct: 124 EETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADT 183
Query: 1248 NQKDQKQKSALDEA---DDEKMKELLRSYGA-IETVN 1280
N + + +AL E+ +D ++ ++L S GA +E+ N
Sbjct: 184 NHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKN 220
Score = 39.7 bits (91), Expect = 0.028
Identities = 29/102 (28%), Positives = 46/102 (45%), Gaps = 1/102 (0%)
Query: 495 KAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKG-GADVNIKGL 553
KA D + + IK+G N+ +P+ GW LHEA+ G L + ++ + L
Sbjct: 63 KAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTL 122
Query: 554 YQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
+ T ++ A GH LL GA+P N + L +A
Sbjct: 123 QEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKA 164
Score = 31.2 bits (69), Expect = 9.9
Identities = 25/108 (23%), Positives = 47/108 (43%)
Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
+I++R + E VY A D + ++ G + + + T L++A
Sbjct: 116 TIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKI 175
Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDG 588
L++ AD N + T LH++V +V ++L+ GA +N G
Sbjct: 176 LVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYG 223
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.128 0.360
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,981,522
Number of Sequences: 37866
Number of extensions: 3280781
Number of successful extensions: 13005
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 333
Number of HSP's successfully gapped in prelim test: 183
Number of HSP's that attempted gapping in prelim test: 8459
Number of HSP's gapped (non-prelim): 3519
length of query: 1873
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1756
effective length of database: 13,817,196
effective search space: 24262996176
effective search space used: 24262996176
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.