BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|237858680 neurofascin isoform 5 precursor [Homo sapiens] (619 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|237858680 neurofascin isoform 5 precursor [Homo sapiens] 1281 0.0 gi|237858682 neurofascin isoform 6 precursor [Homo sapiens] 1262 0.0 gi|237858675 neurofascin isoform 1 precursor [Homo sapiens] 1255 0.0 gi|237858679 neurofascin isoform 3 precursor [Homo sapiens] 1226 0.0 gi|89903008 neurofascin isoform 4 precursor [Homo sapiens] 1226 0.0 gi|237858677 neurofascin isoform 2 precursor [Homo sapiens] 1224 0.0 gi|81158226 neuronal cell adhesion molecule isoform A precursor ... 672 0.0 gi|81158224 neuronal cell adhesion molecule isoform B precursor ... 660 0.0 gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 455 e-128 gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ... 452 e-127 gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s... 452 e-127 gi|27894376 cell adhesion molecule with homology to L1CAM precur... 406 e-113 gi|7657359 contactin 5 isoform long [Homo sapiens] 244 2e-64 gi|28373129 contactin 5 isoform short [Homo sapiens] 244 2e-64 gi|28373122 contactin 4 isoform a precursor [Homo sapiens] 232 7e-61 gi|4827022 contactin 2 precursor [Homo sapiens] 226 5e-59 gi|75709184 contactin 3 [Homo sapiens] 224 2e-58 gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens] 219 4e-57 gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens] 219 4e-57 gi|7657361 contactin 6 [Homo sapiens] 198 1e-50 gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 194 2e-49 gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 192 1e-48 gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 184 3e-46 gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 182 6e-46 gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 181 1e-45 gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 181 1e-45 gi|118572606 hemicentin 1 [Homo sapiens] 180 4e-45 gi|19743806 roundabout 1 isoform b [Homo sapiens] 176 6e-44 gi|4506569 roundabout 1 isoform a [Homo sapiens] 176 6e-44 gi|224994173 roundabout 1 isoform d [Homo sapiens] 171 1e-42 >gi|237858680 neurofascin isoform 5 precursor [Homo sapiens] Length = 619 Score = 1281 bits (3314), Expect = 0.0 Identities = 619/619 (100%), Positives = 619/619 (100%) Query: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL 60 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL Sbjct: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL 60 Query: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA Sbjct: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120 Query: 121 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 180 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM Sbjct: 121 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 180 Query: 181 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA 240 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA Sbjct: 181 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA 240 Query: 241 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA 300 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA Sbjct: 241 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA 300 Query: 301 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA 360 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA Sbjct: 301 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA 360 Query: 361 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 420 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN Sbjct: 361 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 420 Query: 421 AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV 480 AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV Sbjct: 421 AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV 480 Query: 481 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 540 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ Sbjct: 481 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 540 Query: 541 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ 600 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ Sbjct: 541 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ 600 Query: 601 DLAKAYLTVLGNCPCSPWH 619 DLAKAYLTVLGNCPCSPWH Sbjct: 601 DLAKAYLTVLGNCPCSPWH 619 >gi|237858682 neurofascin isoform 6 precursor [Homo sapiens] Length = 613 Score = 1262 bits (3266), Expect = 0.0 Identities = 613/619 (99%), Positives = 613/619 (99%), Gaps = 6/619 (0%) Query: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL 60 MARQPPPPWVHAAFLLCLLSLGGAIEIPMD LTQPPTITKQSAKDHIVDPRDNIL Sbjct: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMD------LTQPPTITKQSAKDHIVDPRDNIL 54 Query: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA Sbjct: 55 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 114 Query: 121 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 180 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM Sbjct: 115 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 174 Query: 181 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA 240 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA Sbjct: 175 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA 234 Query: 241 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA 300 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA Sbjct: 235 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA 294 Query: 301 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA 360 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA Sbjct: 295 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA 354 Query: 361 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 420 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN Sbjct: 355 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 414 Query: 421 AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV 480 AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV Sbjct: 415 AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV 474 Query: 481 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 540 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ Sbjct: 475 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 534 Query: 541 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ 600 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ Sbjct: 535 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ 594 Query: 601 DLAKAYLTVLGNCPCSPWH 619 DLAKAYLTVLGNCPCSPWH Sbjct: 595 DLAKAYLTVLGNCPCSPWH 613 >gi|237858675 neurofascin isoform 1 precursor [Homo sapiens] Length = 1240 Score = 1255 bits (3248), Expect = 0.0 Identities = 610/612 (99%), Positives = 611/612 (99%) Query: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL 60 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL Sbjct: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL 60 Query: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA Sbjct: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120 Query: 121 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 180 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM Sbjct: 121 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 180 Query: 181 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA 240 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA Sbjct: 181 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA 240 Query: 241 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA 300 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA Sbjct: 241 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA 300 Query: 301 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA 360 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA Sbjct: 301 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA 360 Query: 361 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 420 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN Sbjct: 361 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 420 Query: 421 AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV 480 AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV Sbjct: 421 AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV 480 Query: 481 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 540 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ Sbjct: 481 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 540 Query: 541 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ 600 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ Sbjct: 541 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ 600 Query: 601 DLAKAYLTVLGN 612 DLAKAYLTVL + Sbjct: 601 DLAKAYLTVLAD 612 >gi|237858679 neurofascin isoform 3 precursor [Homo sapiens] Length = 1174 Score = 1226 bits (3172), Expect = 0.0 Identities = 604/628 (96%), Positives = 604/628 (96%), Gaps = 23/628 (3%) Query: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL 60 MARQPPPPWVHAAFLLCLLSLGGAIEIPMD LTQPPTITKQSAKDHIVDPRDNIL Sbjct: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMD------LTQPPTITKQSAKDHIVDPRDNIL 54 Query: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA Sbjct: 55 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 114 Query: 121 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 180 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM Sbjct: 115 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 174 Query: 181 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTT---- 236 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLT Sbjct: 175 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYN 234 Query: 237 -------------RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK 283 RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK Sbjct: 235 DSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK 294 Query: 284 GGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 343 GGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP Sbjct: 295 GGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 354 Query: 344 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 403 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR Sbjct: 355 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 414 Query: 404 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 463 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR Sbjct: 415 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 474 Query: 464 WFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR 523 WFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR Sbjct: 475 WFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR 534 Query: 524 IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVA 583 IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVA Sbjct: 535 IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVA 594 Query: 584 ERDQGSYTCVASTELDQDLAKAYLTVLG 611 ERDQGSYTCVASTELDQDLAKAYLTVLG Sbjct: 595 ERDQGSYTCVASTELDQDLAKAYLTVLG 622 Score = 98.2 bits (243), Expect = 2e-20 Identities = 96/390 (24%), Positives = 156/390 (40%), Gaps = 53/390 (13%) Query: 58 NILIECEAKGNPAPSFHWTRN--------SRFFNIAKDPRVSMRRRSGTLVIDFRSGGRP 109 ++L+EC A G P P W + ++F N K R++ Sbjct: 274 DLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRIT---------------NVS 318 Query: 110 EEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQ-EGAPLTLQCNPPPGL 168 EE GEY C A NK G+ + + I ++V +P W E + ++ E L + N G Sbjct: 319 EEDSGEYFCLASNKMGS-IRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRAN---GN 374 Query: 169 PSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTD----YSCNARFHFTHTIQ 224 P P + WM + EP+ + N ++ ++ +D Q Y CN H Sbjct: 375 PKPTVQWMVNG-EPL---QSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNE--HGYL 428 Query: 225 QKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKG 284 N F V + P + P+ ++ L +C G P P + W+K G Sbjct: 429 LANAFV-------SVLDVPPRMLSPRNQLIRVILYNRTRL--DCPFFGSPIPTLRWFKNG 479 Query: 285 GDLPSDKAKFENF-NKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 343 D + + N +L I + +ED G Y C+A+N +G + + + VK P Sbjct: 480 QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP 539 Query: 344 KNLILAPGEDGRLVCRANGNP--KPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQIS 401 ++ + G +L CR +P K TV W+ + EPL + D++ Sbjct: 540 EDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKED---DSLTIFGVAER 596 Query: 402 SRAVYQCNTSNEHGYLLANAFVSVLDVPPR 431 + Y C S E LA A+++VL P R Sbjct: 597 DQGSYTCVASTELDQDLAKAYLTVLGRPDR 626 >gi|89903008 neurofascin isoform 4 precursor [Homo sapiens] Length = 1169 Score = 1226 bits (3172), Expect = 0.0 Identities = 604/628 (96%), Positives = 604/628 (96%), Gaps = 23/628 (3%) Query: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL 60 MARQPPPPWVHAAFLLCLLSLGGAIEIPMD LTQPPTITKQSAKDHIVDPRDNIL Sbjct: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMD------LTQPPTITKQSAKDHIVDPRDNIL 54 Query: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA Sbjct: 55 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 114 Query: 121 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 180 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM Sbjct: 115 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 174 Query: 181 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTT---- 236 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLT Sbjct: 175 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYN 234 Query: 237 -------------RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK 283 RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK Sbjct: 235 DSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK 294 Query: 284 GGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 343 GGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP Sbjct: 295 GGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 354 Query: 344 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 403 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR Sbjct: 355 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 414 Query: 404 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 463 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR Sbjct: 415 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 474 Query: 464 WFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR 523 WFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR Sbjct: 475 WFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR 534 Query: 524 IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVA 583 IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVA Sbjct: 535 IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVA 594 Query: 584 ERDQGSYTCVASTELDQDLAKAYLTVLG 611 ERDQGSYTCVASTELDQDLAKAYLTVLG Sbjct: 595 ERDQGSYTCVASTELDQDLAKAYLTVLG 622 Score = 98.2 bits (243), Expect = 2e-20 Identities = 96/390 (24%), Positives = 156/390 (40%), Gaps = 53/390 (13%) Query: 58 NILIECEAKGNPAPSFHWTRN--------SRFFNIAKDPRVSMRRRSGTLVIDFRSGGRP 109 ++L+EC A G P P W + ++F N K R++ Sbjct: 274 DLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRIT---------------NVS 318 Query: 110 EEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQ-EGAPLTLQCNPPPGL 168 EE GEY C A NK G+ + + I ++V +P W E + ++ E L + N G Sbjct: 319 EEDSGEYFCLASNKMGS-IRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRAN---GN 374 Query: 169 PSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTD----YSCNARFHFTHTIQ 224 P P + WM + EP+ + N ++ ++ +D Q Y CN H Sbjct: 375 PKPTVQWMVNG-EPL---QSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNE--HGYL 428 Query: 225 QKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKG 284 N F V + P + P+ ++ L +C G P P + W+K G Sbjct: 429 LANAFV-------SVLDVPPRMLSPRNQLIRVILYNRTRL--DCPFFGSPIPTLRWFKNG 479 Query: 285 GDLPSDKAKFENF-NKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 343 D + + N +L I + +ED G Y C+A+N +G + + + VK P Sbjct: 480 QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP 539 Query: 344 KNLILAPGEDGRLVCRANGNP--KPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQIS 401 ++ + G +L CR +P K TV W+ + EPL + D++ Sbjct: 540 EDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKED---DSLTIFGVAER 596 Query: 402 SRAVYQCNTSNEHGYLLANAFVSVLDVPPR 431 + Y C S E LA A+++VL P R Sbjct: 597 DQGSYTCVASTELDQDLAKAYLTVLGRPDR 626 >gi|237858677 neurofascin isoform 2 precursor [Homo sapiens] Length = 1189 Score = 1224 bits (3167), Expect = 0.0 Identities = 603/629 (95%), Positives = 604/629 (96%), Gaps = 23/629 (3%) Query: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL 60 MARQPPPPWVHAAFLLCLLSLGGAIEIPMD LTQPPTITKQSAKDHIVDPRDNIL Sbjct: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMD------LTQPPTITKQSAKDHIVDPRDNIL 54 Query: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA Sbjct: 55 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 114 Query: 121 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 180 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM Sbjct: 115 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 174 Query: 181 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTT---- 236 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLT Sbjct: 175 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYN 234 Query: 237 -------------RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK 283 RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK Sbjct: 235 DSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK 294 Query: 284 GGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 343 GGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP Sbjct: 295 GGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 354 Query: 344 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 403 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR Sbjct: 355 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 414 Query: 404 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 463 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR Sbjct: 415 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 474 Query: 464 WFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR 523 WFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR Sbjct: 475 WFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR 534 Query: 524 IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVA 583 IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVA Sbjct: 535 IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVA 594 Query: 584 ERDQGSYTCVASTELDQDLAKAYLTVLGN 612 ERDQGSYTCVASTELDQDLAKAYLTVL + Sbjct: 595 ERDQGSYTCVASTELDQDLAKAYLTVLAD 623 >gi|81158226 neuronal cell adhesion molecule isoform A precursor [Homo sapiens] Length = 1304 Score = 672 bits (1734), Expect = 0.0 Identities = 326/619 (52%), Positives = 429/619 (69%), Gaps = 19/619 (3%) Query: 15 LLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFH 74 +L L + A+E+P+DP + +L QPPTIT+QS KD+I+DPR+NI+I+CEAKG P PSF Sbjct: 20 ILFLCQMISALEVPLDPKLLEDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFS 79 Query: 75 WTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRL 134 WTRN F+I KDP V+M+ +GTL+I+ S G+ E YEG YQC ARN+ G A+SN I + Sbjct: 80 WTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVV 139 Query: 135 QVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHN 194 + S+SPLW KE L+P+ +Q G L L C PP GLP P+IFWM +S + + Q +RVSQG N Sbjct: 140 RPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLN 199 Query: 195 GDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTT------------------ 236 GDLYFSNV+ +D + DY C ARF+ T TIQQK P ++KV++ Sbjct: 200 GDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYG 259 Query: 237 -RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFE 295 + ER P+F+ P+G AS++ LRG L LECIA G+PTP I W K+ G LP ++ ++ Sbjct: 260 AKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYK 319 Query: 296 NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGR 355 NF K L+I +VSE DSG Y C+A N +G+I HTISVRVKAAPYW+ P+NL+L+PGEDG Sbjct: 320 NFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGT 379 Query: 356 LVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHG 415 L+CRANGNPKP + W+ NG P++ AP +P+R++ GDTIIF + Q S AVYQCN SNE+G Sbjct: 380 LICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYG 439 Query: 416 YLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDG 475 YLLANAFV+VL PPR+L+P N L +VI LDC FFGSP+PT+ WFK +GS L Sbjct: 440 YLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHE 499 Query: 476 GNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARR 535 Y ++ENG+LEI + +K+ G YTCVA N LG A+N+V LE+KDPT I + PE V +R Sbjct: 500 DIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQR 559 Query: 536 GTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVAS 595 G+ V EC+VKHD +L LTV WLKD+ L R + D L + V++ D G+YTCVA+ Sbjct: 560 GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVAN 619 Query: 596 TELDQDLAKAYLTVLGNCP 614 T LD A A L+V+ P Sbjct: 620 TTLDSVSASAVLSVVAPTP 638 >gi|81158224 neuronal cell adhesion molecule isoform B precursor [Homo sapiens] Length = 1183 Score = 660 bits (1704), Expect = 0.0 Identities = 324/615 (52%), Positives = 425/615 (69%), Gaps = 25/615 (4%) Query: 15 LLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFH 74 +L L + A+E+P+D L QPPTIT+QS KD+I+DPR+NI+I+CEAKG P PSF Sbjct: 20 ILFLCQMISALEVPLD------LVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFS 73 Query: 75 WTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRL 134 WTRN F+I KDP V+M+ +GTL+I+ S G+ E YEG YQC ARN+ G A+SN I + Sbjct: 74 WTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVV 133 Query: 135 QVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHN 194 + S+SPLW KE L+P+ +Q G L L C PP GLP P+IFWM +S + + Q +RVSQG N Sbjct: 134 RPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLN 193 Query: 195 GDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTT------------------ 236 GDLYFSNV+ +D + DY C ARF+ T TIQQK P ++KV++ Sbjct: 194 GDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYG 253 Query: 237 -RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFE 295 + ER P+F+ P+G AS++ LRG L LECIA G+PTP I W K+ G LP ++ ++ Sbjct: 254 AKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYK 313 Query: 296 NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGR 355 NF K L+I +VSE DSG Y C+A N +G+I HTISVRVKAAPYW+ P+NL+L+PGEDG Sbjct: 314 NFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGT 373 Query: 356 LVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHG 415 L+CRANGNPKP + W+ NG P++ AP +P+R++ GDTIIF + Q S AVYQCN SNE+G Sbjct: 374 LICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYG 433 Query: 416 YLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDG 475 YLLANAFV+VL PPR+L+P N L +VI LDC FFGSP+PT+ WFK +GS L Sbjct: 434 YLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHE 493 Query: 476 GNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARR 535 Y ++ENG+LEI + +K+ G YTCVA N LG A+N+V LE+KDPT I + PE V +R Sbjct: 494 DIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQR 553 Query: 536 GTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVAS 595 G+ V EC+VKHD +L LTV WLKD+ L R + D L + V++ D G+YTCVA+ Sbjct: 554 GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVAN 613 Query: 596 TELDQDLAKAYLTVL 610 T LD A A L+V+ Sbjct: 614 TTLDSVSASAVLSVV 628 Score = 109 bits (272), Expect = 9e-24 Identities = 106/400 (26%), Positives = 169/400 (42%), Gaps = 37/400 (9%) Query: 39 QPPT-ITKQSAKDHIVDPRDNIL-IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96 +PPT +T + + + R N+L +EC A+G P P +W + + R + Sbjct: 260 RPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKED---GMLPKNRTVYKNFE 316 Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLW--PKENLDPVVVQE 154 TL I S E G YQC A+N G A+ + I ++V +P W +NL V+ Sbjct: 317 KTLQIIHVS----EADSGNYQCIAKNALG-AIHHTISVRVKAAPYWITAPQNL---VLSP 368 Query: 155 GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGD-LYFSNVMLQDMQTDYSC 213 G TL C G P P I W+++ + S+ +GD + FSNV + Y C Sbjct: 369 GEDGTLICRAN-GNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAV-YQC 426 Query: 214 NARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGV 273 NA + + + N F V P + P T V+ LL+C G Sbjct: 427 NASNEYGYLLA--NAFV-------NVLAEPPRILTPANTL--YQVIANRPALLDCAFFGS 475 Query: 274 PTPDIAWYK--KGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISV 331 P P I W+K KG L D N L I ++ +G Y C+A NK+G ++ + + Sbjct: 476 PLPTIEWFKGAKGSALHEDIYVLHE-NGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHL 534 Query: 332 RVKAAPYWLDEPKNLILAPGEDGRLVCRANGNP--KPTVQWMVNGEPLQSAPPNPNREVA 389 +K + + +P+ ++ G C+ + TV W+ + L P + V Sbjct: 535 EIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNREL---PSDERFTVD 591 Query: 390 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVP 429 D ++ D Y C + + A+A +SV+DVP Sbjct: 592 KDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVDVP 631 Score = 76.3 bits (186), Expect = 8e-14 Identities = 119/525 (22%), Positives = 193/525 (36%), Gaps = 73/525 (13%) Query: 38 TQPPTITKQSAKDHIVDPRDNILIECEAK-GNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96 ++ P TK+ + + ++++ C G P P W NS F + + RVS + + Sbjct: 136 SRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNS-FQRLPQSERVS-QGLN 193 Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQV-------------------- 136 G L + S PE+ +Y C+AR + + + V Sbjct: 194 GDL---YFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTE 250 Query: 137 ---SKSP-------LWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD 186 +KS L P+ N G L+L+C GLP+P+I+W + ++ Sbjct: 251 FYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAE-GLPTPIIYWAKED-GMLPKN 308 Query: 187 KRVSQGHNGDLYFSNVMLQDMQTDYSC---NARFHFTHTIQQKNPFTLKVLTTRGVAERT 243 + V + L +V D +Y C NA HTI + + Sbjct: 309 RTVYKNFEKTLQIIHVSEAD-SGNYQCIAKNALGAIHHTISVR-------------VKAA 354 Query: 244 PSFMYPQGTASSQMVLR-GMDLLLECIASGVPTPDIAWYKKGGDL---PSDKAKFENFNK 299 P ++ TA +VL G D L C A+G P P I+W G + P D ++ + + Sbjct: 355 PYWI----TAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDT 410 Query: 300 ALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLI--LAPGEDGRLV 357 + +NV E S Y C ASN+ G + V V A P + P N + + L Sbjct: 411 II-FSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLD 469 Query: 358 CRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYL 417 C G+P PT++W G + + T+ Q S Y C N+ G Sbjct: 470 CAFFGSPLPTIEWF-KGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMA 528 Query: 418 LANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR--WFKNGQGSNLDG 475 + + D P + + + V + +C +L W K+ + L Sbjct: 529 KNEVHLEIKD--PTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNR--ELPS 584 Query: 476 GNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKD 520 + L + + +D G YTCVA L L V D Sbjct: 585 DERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVD 629 Score = 73.6 bits (179), Expect = 5e-13 Identities = 86/343 (25%), Positives = 133/343 (38%), Gaps = 45/343 (13%) Query: 52 IVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEE 111 ++ P ++ + C A GNP P W N IA D R+ G +I E Sbjct: 365 VLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDD--PSRKIDGDTII---FSNVQER 419 Query: 112 YEGEYQCFARNKFGTALSNRIRLQVSKSP--LWPKENLDPVVVQEGAPLTLQCNPPPGLP 169 YQC A N++G L+N +++ P L P L V+ P L C G P Sbjct: 420 SSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANR--PALLDC-AFFGSP 476 Query: 170 SPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPF 229 P I W + + NG L V +D Y+C AR KN Sbjct: 477 LPTIEWFKGAKGSALHEDIYVLHENGTLEIP-VAQKDSTGTYTCVARNKLG---MAKNEV 532 Query: 230 TLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIA--WYKKGGDL 287 L++ + P+++ Q + +V RG + EC T + W K +L Sbjct: 533 HLEI--------KDPTWIVKQPEYA--VVQRGSMVSFECKVKHDHTLSLTVLWLKDNREL 582 Query: 288 PSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPY--------- 338 PSD+ +F L + +VS++DSG Y C+A+ + S+ + + V P Sbjct: 583 PSDE-RFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVDVPNPPFDLELTD 641 Query: 339 WLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAP 381 LD+ L PG+D N P ++++ E P Sbjct: 642 QLDKSVQLSWTPGDD---------NNSPITKFIIEYEDAMHKP 675 >gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo sapiens] Length = 1248 Score = 455 bits (1171), Expect = e-128 Identities = 229/585 (39%), Positives = 339/585 (57%), Gaps = 5/585 (0%) Query: 33 IQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSM 92 I EL +PP IT+QS + +V P D+I ++CEA G P F WTR+ F ++ V++ Sbjct: 22 IPEELMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTV 81 Query: 93 RR--RSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV 150 + SG+ I + + ++G Y+CFA NK GTA+S+ IRL +P WPKE + PV Sbjct: 82 YQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPV 141 Query: 151 VVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTD 210 V+EG + L CNPPP I+WM+S + I QD+RV+ G NG+LYF+NV+ D +D Sbjct: 142 EVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSD 201 Query: 211 YSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIA 270 Y C+A F T TI QK P L+V T + +R P ++P ++S + L+G L+LECIA Sbjct: 202 YICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIA 261 Query: 271 SGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTIS 330 G PTP I W + G +P+D+ ++N NK L++ V EED GEY CLA N +GS RH Sbjct: 262 EGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYY 321 Query: 331 VRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAG 390 V V+AAPYWL +P++ + PGE RL C+ G P+P V W +NG P++ + + Sbjct: 322 VTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQR 381 Query: 391 DTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRL 450 +I + Q S V QC N HG LLANA++ V+ +P ++L+ NQ + + L Sbjct: 382 GALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYL 441 Query: 451 DCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKA 510 C FG+P+P+++W + L + Y NG+L I+ ++ D G Y C+A N Sbjct: 442 LCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNV 501 Query: 511 ENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLY-IGNR 569 L+VKD T+I + P + ++G+ V C+ DPSL+ +++W D L +G+ Sbjct: 502 TIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDS 561 Query: 570 MKK--EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGN 612 K ED L I + DQG+Y+CVASTELD ++A L V+G+ Sbjct: 562 DKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGS 606 Score = 67.0 bits (162), Expect = 5e-11 Identities = 72/295 (24%), Positives = 119/295 (40%), Gaps = 28/295 (9%) Query: 49 KDHIVDPRDNILIECEAKGNPAPSFHWTRNS-RFFNIAKDPRVSMRRRSGTLVIDFRSGG 107 + H+ P + ++C+ +G P P W N +AKD + ++R G L++ S Sbjct: 335 QSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQR--GALIL---SNV 389 Query: 108 RPEEYEGEYQCFARNKFGTALSNRIRLQVS-KSPLWPKENLDPVVVQEGAPLTLQCNPPP 166 +P + QC ARN+ G L+N V + + +N + VQ G+ L C Sbjct: 390 QPSDTMVT-QCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQ-GSTAYLLCKAF- 446 Query: 167 GLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQK 226 G P P + W+ + QD+R NG L ++ D R+ Q Sbjct: 447 GAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQAND-------TGRYFCLAANDQN 499 Query: 227 NPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT--PDIAWYKKG 284 N + ++ V + T P+ T +G + C AS P+ P I W G Sbjct: 500 N---VTIMANLKVKDATQITQGPRSTIEK----KGSRVTFTCQASFDPSLQPSITWRGDG 552 Query: 285 GDLPS--DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAP 337 DL D K+ + L I ++ D G Y C+AS ++ + + V +P Sbjct: 553 RDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSP 607 >gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo sapiens] Length = 1253 Score = 452 bits (1162), Expect = e-127 Identities = 232/601 (38%), Positives = 346/601 (57%), Gaps = 11/601 (1%) Query: 17 CLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWT 76 CLL I+IP + + + +PP IT+QS + +V P D+I ++CEA G P F WT Sbjct: 17 CLL-----IQIPEEYE-GHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWT 70 Query: 77 RNSRFFNIAKDPRVSMRR--RSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRL 134 R+ F ++ V++ + SG+ I + + ++G Y+CFA NK GTA+S+ IRL Sbjct: 71 RDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRL 130 Query: 135 QVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHN 194 +P WPKE + PV V+EG + L CNPPP I+WM+S + I QD+RV+ G N Sbjct: 131 MAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQN 190 Query: 195 GDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTAS 254 G+LYF+NV+ D +DY C+A F T TI QK P L+V T + +R P ++P ++S Sbjct: 191 GNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSS 250 Query: 255 SQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEY 314 + L+G L+LECIA G PTP I W + G +P+D+ ++N NK L++ V EED GEY Sbjct: 251 HLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEY 310 Query: 315 FCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNG 374 CLA N +GS RH V V+AAPYWL +P++ + PGE RL C+ G P+P V W +NG Sbjct: 311 RCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRING 370 Query: 375 EPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLS 434 P++ + + +I + Q S V QC N HG LLANA++ V+ +P ++L+ Sbjct: 371 IPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILT 430 Query: 435 PRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKE 494 NQ + + L C FG+P+P+++W + L + Y NG+L I+ ++ Sbjct: 431 ADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQAN 490 Query: 495 DQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLT 554 D G Y C+A N L+VKD T+I + P + ++G+ V C+ DPSL+ + Sbjct: 491 DTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPS 550 Query: 555 VSWLKDDEPLY-IGNRMKK--EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLG 611 ++W D L +G+ K ED L I + DQG+Y+CVASTELD ++A L V+G Sbjct: 551 ITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVG 610 Query: 612 N 612 + Sbjct: 611 S 611 Score = 67.0 bits (162), Expect = 5e-11 Identities = 72/295 (24%), Positives = 119/295 (40%), Gaps = 28/295 (9%) Query: 49 KDHIVDPRDNILIECEAKGNPAPSFHWTRNS-RFFNIAKDPRVSMRRRSGTLVIDFRSGG 107 + H+ P + ++C+ +G P P W N +AKD + ++R G L++ S Sbjct: 340 QSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQR--GALIL---SNV 394 Query: 108 RPEEYEGEYQCFARNKFGTALSNRIRLQVS-KSPLWPKENLDPVVVQEGAPLTLQCNPPP 166 +P + QC ARN+ G L+N V + + +N + VQ G+ L C Sbjct: 395 QPSDTMVT-QCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQ-GSTAYLLCKAF- 451 Query: 167 GLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQK 226 G P P + W+ + QD+R NG L ++ D R+ Q Sbjct: 452 GAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQAND-------TGRYFCLAANDQN 504 Query: 227 NPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT--PDIAWYKKG 284 N + ++ V + T P+ T +G + C AS P+ P I W G Sbjct: 505 N---VTIMANLKVKDATQITQGPRSTIEK----KGSRVTFTCQASFDPSLQPSITWRGDG 557 Query: 285 GDLPS--DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAP 337 DL D K+ + L I ++ D G Y C+AS ++ + + V +P Sbjct: 558 RDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSP 612 >gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo sapiens] Length = 1257 Score = 452 bits (1162), Expect = e-127 Identities = 232/601 (38%), Positives = 346/601 (57%), Gaps = 11/601 (1%) Query: 17 CLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWT 76 CLL I+IP + + + +PP IT+QS + +V P D+I ++CEA G P F WT Sbjct: 17 CLL-----IQIPEEYE-GHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWT 70 Query: 77 RNSRFFNIAKDPRVSMRR--RSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRL 134 R+ F ++ V++ + SG+ I + + ++G Y+CFA NK GTA+S+ IRL Sbjct: 71 RDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRL 130 Query: 135 QVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHN 194 +P WPKE + PV V+EG + L CNPPP I+WM+S + I QD+RV+ G N Sbjct: 131 MAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQN 190 Query: 195 GDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTAS 254 G+LYF+NV+ D +DY C+A F T TI QK P L+V T + +R P ++P ++S Sbjct: 191 GNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSS 250 Query: 255 SQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEY 314 + L+G L+LECIA G PTP I W + G +P+D+ ++N NK L++ V EED GEY Sbjct: 251 HLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEY 310 Query: 315 FCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNG 374 CLA N +GS RH V V+AAPYWL +P++ + PGE RL C+ G P+P V W +NG Sbjct: 311 RCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRING 370 Query: 375 EPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLS 434 P++ + + +I + Q S V QC N HG LLANA++ V+ +P ++L+ Sbjct: 371 IPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILT 430 Query: 435 PRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKE 494 NQ + + L C FG+P+P+++W + L + Y NG+L I+ ++ Sbjct: 431 ADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQAN 490 Query: 495 DQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLT 554 D G Y C+A N L+VKD T+I + P + ++G+ V C+ DPSL+ + Sbjct: 491 DTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPS 550 Query: 555 VSWLKDDEPLY-IGNRMKK--EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLG 611 ++W D L +G+ K ED L I + DQG+Y+CVASTELD ++A L V+G Sbjct: 551 ITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVG 610 Query: 612 N 612 + Sbjct: 611 S 611 Score = 67.0 bits (162), Expect = 5e-11 Identities = 72/295 (24%), Positives = 119/295 (40%), Gaps = 28/295 (9%) Query: 49 KDHIVDPRDNILIECEAKGNPAPSFHWTRNS-RFFNIAKDPRVSMRRRSGTLVIDFRSGG 107 + H+ P + ++C+ +G P P W N +AKD + ++R G L++ S Sbjct: 340 QSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQR--GALIL---SNV 394 Query: 108 RPEEYEGEYQCFARNKFGTALSNRIRLQVS-KSPLWPKENLDPVVVQEGAPLTLQCNPPP 166 +P + QC ARN+ G L+N V + + +N + VQ G+ L C Sbjct: 395 QPSDTMVT-QCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQ-GSTAYLLCKAF- 451 Query: 167 GLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQK 226 G P P + W+ + QD+R NG L ++ D R+ Q Sbjct: 452 GAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQAND-------TGRYFCLAANDQN 504 Query: 227 NPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT--PDIAWYKKG 284 N + ++ V + T P+ T +G + C AS P+ P I W G Sbjct: 505 N---VTIMANLKVKDATQITQGPRSTIEK----KGSRVTFTCQASFDPSLQPSITWRGDG 557 Query: 285 GDLPS--DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAP 337 DL D K+ + L I ++ D G Y C+AS ++ + + V +P Sbjct: 558 RDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSP 612 >gi|27894376 cell adhesion molecule with homology to L1CAM precursor [Homo sapiens] Length = 1224 Score = 406 bits (1044), Expect = e-113 Identities = 240/627 (38%), Positives = 331/627 (52%), Gaps = 47/627 (7%) Query: 15 LLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL-IECEAKGNPAPSF 73 + LL AIEIP + + Q PTI KQS K + P D IECEAKGNP P+F Sbjct: 15 MFLLLKFSKAIEIP------SSVQQVPTIIKQS-KVQVAFPFDEYFQIECEAKGNPEPTF 67 Query: 74 HWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIR 133 WT++ F D R+ SGT I + G ++G+Y+CFA NK G A+S I Sbjct: 68 SWTKDGNPFYFT-DHRIIPSNNSGTFRIP--NEGHISHFQGKYRCFASNKLGIAMSEEIE 124 Query: 134 LQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGH 193 V P +PKE +DP+ V+EG P+ L CNPP GLP I+WM+ +E I QD+RV Sbjct: 125 FIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQ 184 Query: 194 NGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTR---------------- 237 GDLYF+NV +D + DY C A F TI QK P L V + + Sbjct: 185 KGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKAN 244 Query: 238 GVAERTPSFMYP---QGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKF 294 + +R P + P G+ SS +L+G LLLEC A G+PTP + W K GGDLP + Sbjct: 245 SIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETK 304 Query: 295 ENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDG 354 EN+ K L+I NVS +D G Y C ASN +G+ H V V+ P W +P++ + + G +G Sbjct: 305 ENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNG 364 Query: 355 RLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTII-----FRDTQISSRAVYQCN 409 L+C A G P+PT++W VNG P+ + P AGD + F + Q + AVYQC Sbjct: 365 ILLCEAEGEPQPTIKWRVNGSPVDNHP------FAGDVVFPREISFTNLQPNHTAVYQCE 418 Query: 410 TSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ 469 SN HG +LANA + V+DV P + + + ++ L C FF SP + W K + Sbjct: 419 ASNVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEE 478 Query: 470 GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE 529 L+G YH+YENG+L+I +ED G Y+C N +GK L++++ T++ P+ Sbjct: 479 VKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPK 538 Query: 530 DQVARRGTTVQLECRVKHDPSLK--LTVSWLKDDEPLYIG----NRMKKEDDSLTIFGVA 583 + + ++L C K D LK L +SW KD E I R+ + +LTI V Sbjct: 539 NPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVT 598 Query: 584 ERDQGSYTCVASTELDQDLAKAYLTVL 610 DQG Y C A T LD +TVL Sbjct: 599 LEDQGIYCCSAHTALDSAADITQVTVL 625 Score = 82.4 bits (202), Expect = 1e-15 Identities = 128/580 (22%), Positives = 208/580 (35%), Gaps = 93/580 (16%) Query: 27 IPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEA-KGNPAPSFHWTRNSRFFNIA 85 I M I+ + P K+ V+ D I++ C KG P +W N +I Sbjct: 117 IAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWM-NIELEHIE 175 Query: 86 KDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFAR------------------------ 121 +D RV M ++ + ++ +Y CFA Sbjct: 176 QDERVYMSQKGDLYFANVEE----KDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHAN 231 Query: 122 -----NKFGTALSNRIRLQVSKSPLWPKEN--LDPVVVQEGAPLTLQCNPPPGLPSPVIF 174 + G+ +N I+ + K L P E+ + + +G L L+C GLP+P + Sbjct: 232 DSSSSTEIGSK-ANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAE-GLPTPQVD 289 Query: 175 WMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR------FHFTHTIQQKNP 228 W + + + + + + L NV QD + +Y C A H H I ++ P Sbjct: 290 WNKIGGD-LPKGRETKENYGKTLKIENVSYQD-KGNYRCTASNFLGTATHDFHVIVEEPP 347 Query: 229 FTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLP 288 K PQ S G + +L C A G P P I W G P Sbjct: 348 RWTKK---------------PQSAVYST----GSNGILLCEAEGEPQPTIKWRVNGS--P 386 Query: 289 SDKAKFEN---FNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLD--EP 343 D F F + + TN+ + Y C ASN G+I ++ V + + Sbjct: 387 VDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDG 446 Query: 344 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV---AGDTIIFRDTQI 400 +N G L C +P+ V W + ++ P R T+ T Sbjct: 447 ENYATVVGYSAFLHCEFFASPEAVVSW----QKVEEVKPLEGRRYHIYENGTLQINRTTE 502 Query: 401 SSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVI----LYNRTRLDCPFFG 456 Y C N G A + + + +SP+N I + L+ ++ D Sbjct: 503 EDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKH 562 Query: 457 SPIPTLRWFKNGQGSNLDG--GNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQV 514 S L W K+G+ ++G + + +L I + EDQGIY C A L A + Sbjct: 563 SL--KLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADIT 620 Query: 515 R---LEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSL 551 + L+V DP + E Q R + E H+ ++ Sbjct: 621 QVTVLDVPDPPENLHLSERQ--NRSVRLTWEAGADHNSNI 658 >gi|7657359 contactin 5 isoform long [Homo sapiens] Length = 1100 Score = 244 bits (623), Expect = 2e-64 Identities = 173/582 (29%), Positives = 260/582 (44%), Gaps = 38/582 (6%) Query: 50 DHIVDPRDN----ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 105 D I+ P D+ + + CE +GNP PS+ W RN ++ D R S+ GT +I S Sbjct: 106 DDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI--DGTFIISNPS 163 Query: 106 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPP 165 + G YQC A N G+ LS LQ + + V V+EG + L C+PP Sbjct: 164 EAKDS---GHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPP 220 Query: 166 PGLPSPVIFWMSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHT 222 P P + W+ + + +D R +SQ G+LY S V D+ + Y C + T+ Sbjct: 221 PHSPEIIYSWVFNEFPSFVAEDSRRFISQ-ETGNLYISKVQTSDVGS-YICLVKNTVTNA 278 Query: 223 --IQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAW 280 + P TL+ G E +P ++ +G + +EC A G P P I W Sbjct: 279 RVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAA----KGTTVKMECFALGNPVPTITW 334 Query: 281 YKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWL 340 K G +PS KA+ L I NV +D+G Y C A N G ++V P+W+ Sbjct: 335 MKVNGYIPS-KARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWV 393 Query: 341 DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQI 400 ++ + L G R C+A G P+PT +W+ NG PL P E+ ++ + Sbjct: 394 EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLS---PQSRVEMVNGVLMIHNVNQ 450 Query: 401 SSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR---LDCPFFGS 457 S +YQC N++G + A+A + +L P NQL + I+ + + ++C GS Sbjct: 451 SDAGMYQCLAENKYGAIYASAELKILASAPTFAL--NQLKKTIIVTKDQEVVIECKPQGS 508 Query: 458 PIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLE 517 P PT+ W K G + + + +GSL I K D+G Y C N+ G AE L Sbjct: 509 PKPTISW-KKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLS 567 Query: 518 VKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL--------YIGNR 569 VK+PTRI P+ G ++ L C+ HD SL +T W +P+ + R Sbjct: 568 VKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIR 627 Query: 570 MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLG 611 + L I + G Y C T D +A L V G Sbjct: 628 AQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRG 669 Score = 88.6 bits (218), Expect = 2e-17 Identities = 97/374 (25%), Positives = 154/374 (41%), Gaps = 39/374 (10%) Query: 266 LECIASGVPTPDIAWYKKGG--DLPSDKAKFENFNKALRITNVSE-EDSGEYFCLASNKM 322 L C G P P W + G DL SD ++ + I+N SE +DSG Y CLA+N + Sbjct: 121 LNCEVRGNPVPSYRWLRNGTEIDLESDY-RYSLIDGTFIISNPSEAKDSGHYQCLATNTV 179 Query: 323 GSI-RHTISVRVKAAPYWLDEPKNLI-LAPGEDGRLVCRANGN-PKPTVQWMVNGEPLQS 379 GSI +++ + ++ + + G+ L+C + P+ W+ N P Sbjct: 180 GSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFV 239 Query: 380 APPNPNREVAGDT--IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRN 437 A + R ++ +T + Q S Y C N + NA V PP L+ RN Sbjct: 240 AEDS-RRFISQETGNLYISKVQTSDVGSYICLVKNT----VTNARVLS---PPTPLTLRN 291 Query: 438 Q----------------LIRVILYNRTRLDCPFFGSPIPTLRWFK-NGQGSNLDGGNYHV 480 + +++C G+P+PT+ W K NG + Sbjct: 292 DGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGY---IPSKARLR 348 Query: 481 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 540 LEI ++ +D GIY C A N GK + +L+V D G+ ++ Sbjct: 349 KSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLR 408 Query: 541 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ 600 EC+ P + T WLK+ PL +R++ + L I V + D G Y C+A + Sbjct: 409 WECKATGKP--RPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGA 466 Query: 601 DLAKAYLTVLGNCP 614 A A L +L + P Sbjct: 467 IYASAELKILASAP 480 Score = 66.2 bits (160), Expect = 8e-11 Identities = 65/304 (21%), Positives = 122/304 (40%), Gaps = 38/304 (12%) Query: 46 QSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 105 + D +D + EC+A G P P++ W +N + P+ + +G L+I Sbjct: 394 EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKN----GVPLSPQSRVEMVNGVLMIH--- 446 Query: 106 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENL-DPVVVQEGAPLTLQCNP 164 + G YQC A NK+G ++ ++ +P + L ++V + + ++C Sbjct: 447 -NVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECK- 504 Query: 165 PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQ 224 P G P P I W + ++KR++ +G L N D + Y C F Sbjct: 505 PQGSPKPTISWKKGD-RAVRENKRIAILPDGSLRILNASKSD-EGKYVCRGENVFG---- 558 Query: 225 QKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWY--- 281 + +++ + V E T + P+ T + G ++L C A + D+ +Y Sbjct: 559 -----SAEIIASLSVKEPTRIELTPKRTE----LTVGESIVLNCKAIHDASLDVTFYWTL 609 Query: 282 --------KKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRV 333 ++GG S +A+ + + L I N+ +G Y C S+ + V Sbjct: 610 KGQPIDFEEEGGHFESIRAQASSAD--LMIRNILLMHAGRYGCRVQTTADSVSDEAELLV 667 Query: 334 KAAP 337 + P Sbjct: 668 RGPP 671 Score = 43.9 bits (102), Expect = 4e-04 Identities = 38/178 (21%), Positives = 76/178 (42%), Gaps = 21/178 (11%) Query: 37 LTQPPTITKQSAKDHIVDPRDN-ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR 95 L PT K I+ +D ++IEC+ +G+P P+ W + R + ++ R+++ Sbjct: 476 LASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDR--AVRENKRIAILPD 533 Query: 96 SGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA--LSNRIRLQVSKSPLWPKENLDPVVVQ 153 +++ + EG+Y C N FG+A +++ + ++ L PK + Sbjct: 534 GSLRILN-----ASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKR----TELT 584 Query: 154 EGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKR-------VSQGHNGDLYFSNVML 204 G + L C V F+ + +PI ++ +Q + DL N++L Sbjct: 585 VGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILL 642 >gi|28373129 contactin 5 isoform short [Homo sapiens] Length = 1026 Score = 244 bits (623), Expect = 2e-64 Identities = 173/582 (29%), Positives = 260/582 (44%), Gaps = 38/582 (6%) Query: 50 DHIVDPRDN----ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 105 D I+ P D+ + + CE +GNP PS+ W RN ++ D R S+ GT +I S Sbjct: 32 DDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI--DGTFIISNPS 89 Query: 106 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPP 165 + G YQC A N G+ LS LQ + + V V+EG + L C+PP Sbjct: 90 EAKDS---GHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPP 146 Query: 166 PGLPSPVIFWMSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHT 222 P P + W+ + + +D R +SQ G+LY S V D+ + Y C + T+ Sbjct: 147 PHSPEIIYSWVFNEFPSFVAEDSRRFISQ-ETGNLYISKVQTSDVGS-YICLVKNTVTNA 204 Query: 223 --IQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAW 280 + P TL+ G E +P ++ +G + +EC A G P P I W Sbjct: 205 RVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAA----KGTTVKMECFALGNPVPTITW 260 Query: 281 YKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWL 340 K G +PS KA+ L I NV +D+G Y C A N G ++V P+W+ Sbjct: 261 MKVNGYIPS-KARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWV 319 Query: 341 DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQI 400 ++ + L G R C+A G P+PT +W+ NG PL P E+ ++ + Sbjct: 320 EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLS---PQSRVEMVNGVLMIHNVNQ 376 Query: 401 SSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR---LDCPFFGS 457 S +YQC N++G + A+A + +L P NQL + I+ + + ++C GS Sbjct: 377 SDAGMYQCLAENKYGAIYASAELKILASAPTFAL--NQLKKTIIVTKDQEVVIECKPQGS 434 Query: 458 PIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLE 517 P PT+ W K G + + + +GSL I K D+G Y C N+ G AE L Sbjct: 435 PKPTISW-KKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLS 493 Query: 518 VKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL--------YIGNR 569 VK+PTRI P+ G ++ L C+ HD SL +T W +P+ + R Sbjct: 494 VKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIR 553 Query: 570 MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLG 611 + L I + G Y C T D +A L V G Sbjct: 554 AQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRG 595 Score = 88.6 bits (218), Expect = 2e-17 Identities = 97/374 (25%), Positives = 154/374 (41%), Gaps = 39/374 (10%) Query: 266 LECIASGVPTPDIAWYKKGG--DLPSDKAKFENFNKALRITNVSE-EDSGEYFCLASNKM 322 L C G P P W + G DL SD ++ + I+N SE +DSG Y CLA+N + Sbjct: 47 LNCEVRGNPVPSYRWLRNGTEIDLESDY-RYSLIDGTFIISNPSEAKDSGHYQCLATNTV 105 Query: 323 GSI-RHTISVRVKAAPYWLDEPKNLI-LAPGEDGRLVCRANGN-PKPTVQWMVNGEPLQS 379 GSI +++ + ++ + + G+ L+C + P+ W+ N P Sbjct: 106 GSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFV 165 Query: 380 APPNPNREVAGDT--IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRN 437 A + R ++ +T + Q S Y C N + NA V PP L+ RN Sbjct: 166 AEDS-RRFISQETGNLYISKVQTSDVGSYICLVKNT----VTNARVLS---PPTPLTLRN 217 Query: 438 Q----------------LIRVILYNRTRLDCPFFGSPIPTLRWFK-NGQGSNLDGGNYHV 480 + +++C G+P+PT+ W K NG + Sbjct: 218 DGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGY---IPSKARLR 274 Query: 481 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 540 LEI ++ +D GIY C A N GK + +L+V D G+ ++ Sbjct: 275 KSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLR 334 Query: 541 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ 600 EC+ P + T WLK+ PL +R++ + L I V + D G Y C+A + Sbjct: 335 WECKATGKP--RPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGA 392 Query: 601 DLAKAYLTVLGNCP 614 A A L +L + P Sbjct: 393 IYASAELKILASAP 406 Score = 66.2 bits (160), Expect = 8e-11 Identities = 65/304 (21%), Positives = 122/304 (40%), Gaps = 38/304 (12%) Query: 46 QSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 105 + D +D + EC+A G P P++ W +N + P+ + +G L+I Sbjct: 320 EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKN----GVPLSPQSRVEMVNGVLMIH--- 372 Query: 106 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENL-DPVVVQEGAPLTLQCNP 164 + G YQC A NK+G ++ ++ +P + L ++V + + ++C Sbjct: 373 -NVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECK- 430 Query: 165 PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQ 224 P G P P I W + ++KR++ +G L N D + Y C F Sbjct: 431 PQGSPKPTISWKKGD-RAVRENKRIAILPDGSLRILNASKSD-EGKYVCRGENVFG---- 484 Query: 225 QKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWY--- 281 + +++ + V E T + P+ T + G ++L C A + D+ +Y Sbjct: 485 -----SAEIIASLSVKEPTRIELTPKRTE----LTVGESIVLNCKAIHDASLDVTFYWTL 535 Query: 282 --------KKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRV 333 ++GG S +A+ + + L I N+ +G Y C S+ + V Sbjct: 536 KGQPIDFEEEGGHFESIRAQASSAD--LMIRNILLMHAGRYGCRVQTTADSVSDEAELLV 593 Query: 334 KAAP 337 + P Sbjct: 594 RGPP 597 Score = 43.9 bits (102), Expect = 4e-04 Identities = 38/178 (21%), Positives = 76/178 (42%), Gaps = 21/178 (11%) Query: 37 LTQPPTITKQSAKDHIVDPRDN-ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR 95 L PT K I+ +D ++IEC+ +G+P P+ W + R + ++ R+++ Sbjct: 402 LASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDR--AVRENKRIAILPD 459 Query: 96 SGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA--LSNRIRLQVSKSPLWPKENLDPVVVQ 153 +++ + EG+Y C N FG+A +++ + ++ L PK + Sbjct: 460 GSLRILN-----ASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKR----TELT 510 Query: 154 EGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKR-------VSQGHNGDLYFSNVML 204 G + L C V F+ + +PI ++ +Q + DL N++L Sbjct: 511 VGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILL 568 >gi|28373122 contactin 4 isoform a precursor [Homo sapiens] Length = 1026 Score = 232 bits (592), Expect = 7e-61 Identities = 167/566 (29%), Positives = 253/566 (44%), Gaps = 29/566 (5%) Query: 59 ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQC 118 + + CE KGNP P W N + D R S+ G+L+I+ + G YQC Sbjct: 46 VKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVE--GSLLIN---NPNKTQDAGTYQC 100 Query: 119 FARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSS 178 A N FGT +S +LQ + + V V+ G + L C PPP W+ + Sbjct: 101 TATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFN 160 Query: 179 SMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTH--TIQQKNPFTLKVLTT 236 ++R G+LY + V D+ +Y+C T+ + P L+ Sbjct: 161 EYPSYQDNRRFVSQETGNLYIAKVEKSDVG-NYTCVVTNTVTNHKVLGPPTPLILRNDGV 219 Query: 237 RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFEN 296 G E +P+ ++ +G + LEC A G P P I W + G + KA+ Sbjct: 220 MGEYEPKIEVQFPETVPTA----KGATVKLECFALGNPVPTIIWRRADGKPIARKARRHK 275 Query: 297 FNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRL 356 N L I N +ED+G Y C+A N G + A P W+ + ++ +A E+ Sbjct: 276 SNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFW 335 Query: 357 VCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGY 416 C+ANG PKPT +W+ NGEPL + ++ T+ +S +YQC N+HG Sbjct: 336 ECKANGRPKPTYKWLKNGEPLLT---RDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGV 392 Query: 417 LLANAFVSVLDVPP---RMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL 473 + +NA +SV+ V P R L R L++V ++C SP P W K G+ Sbjct: 393 IFSNAELSVIAVGPDFSRTLLKRVTLVKV--GGEVVIECKPKASPKPVYTW-KKGRDILK 449 Query: 474 DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVA 533 + + E+G+L I + K D G YTC+ATN G A + L VKDPTR+ P Sbjct: 450 ENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDV 509 Query: 534 RRGTTVQLECRVKHDPSLKLTVSW------LKDDEPLYIGNRMKKEDDS--LTIFGVAER 585 G ++ L C+V HD SL + +W + D R+ +D + L I + + Sbjct: 510 TVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLK 569 Query: 586 DQGSYTCVASTELDQDLAKAYLTVLG 611 G Y C+ T +D+ A A L V G Sbjct: 570 HAGKYVCMVQTSVDRLSAAADLIVRG 595 Score = 88.6 bits (218), Expect = 2e-17 Identities = 101/373 (27%), Positives = 156/373 (41%), Gaps = 38/373 (10%) Query: 266 LECIASGVPTPDIAWYKKGGDLPSDKA-KFENFNKALRITNVSE-EDSGEYFCLASNKMG 323 L C G P P I W G D+ + ++ +L I N ++ +D+G Y C A+N G Sbjct: 48 LNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFG 107 Query: 324 SIRHTISVRVKAAPYWLDEPKN-----LILAPGEDGRLVCRANGNPKP-----TVQWMVN 373 +I +S K +LD K + + G+ L+C P P + W+ N Sbjct: 108 TI---VSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLC----GPPPHSGELSYAWIFN 160 Query: 374 GEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQC---NTSNEHGYL-------LANAFV 423 P + G+ I + + S Y C NT H L L N V Sbjct: 161 EYPSYQDNRRFVSQETGNLYIAK-VEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGV 219 Query: 424 SVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYEN 483 + + P++ + + +L+C G+P+PT+ W + G + N Sbjct: 220 -MGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIW-RRADGKPIARKARRHKSN 277 Query: 484 GSLEIKMIRKEDQGIYTCVATNILGK--AENQVRLEVKDPTRIYRMPEDQVARRGTTVQL 541 G LEI ++ED G+Y CVA N GK A Q+ + P I ++ + VA V Sbjct: 278 GILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQ-PNWIQKINDIHVAME-ENVFW 335 Query: 542 ECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQD 601 EC+ P K T WLK+ EPL +R++ E +L I V D G Y C+A + Sbjct: 336 ECKANGRP--KPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVI 393 Query: 602 LAKAYLTVLGNCP 614 + A L+V+ P Sbjct: 394 FSNAELSVIAVGP 406 Score = 70.9 bits (172), Expect = 3e-12 Identities = 73/307 (23%), Positives = 120/307 (39%), Gaps = 44/307 (14%) Query: 46 QSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 105 Q D V +N+ EC+A G P P++ W +N + R+ + + + + I S Sbjct: 320 QKINDIHVAMEENVFWECKANGRPKPTYKWLKNGE--PLLTRDRIQIEQGTLNITIVNLS 377 Query: 106 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV-VVQEGAPLTLQCNP 164 G YQC A NK G SN ++ P + + L V +V+ G + ++C P Sbjct: 378 DA------GMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKP 431 Query: 165 PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQ 224 P PV W + + +++R++ +G+L NV D + Y+C A HF Sbjct: 432 KAS-PKPVYTW-KKGRDILKENERITISEDGNLRIINVTKSDAGS-YTCIATNHF----- 483 Query: 225 QKNPFTLKVLTTRGVAERTPSFMYPQGT-----ASSQMVLRGMDLLLECIASGVPTPDI- 278 G A T + + T SS V G ++L C + + DI Sbjct: 484 -------------GTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIV 530 Query: 279 -AWYKKGG--DLPSDKAKFENFNKA-----LRITNVSEEDSGEYFCLASNKMGSIRHTIS 330 W G D D FE L I N+ + +G+Y C+ + + Sbjct: 531 FTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAAD 590 Query: 331 VRVKAAP 337 + V+ P Sbjct: 591 LIVRGPP 597 Score = 58.5 bits (140), Expect = 2e-08 Identities = 48/157 (30%), Positives = 75/157 (47%), Gaps = 12/157 (7%) Query: 447 RTRLDCPFFGSPIPTLRWFKNGQGSNLDGG---NYHVYENGSLEIKMIRKEDQGIYTCVA 503 + +L+C G+P P +RW N G+++D G Y V E L + +D G Y C A Sbjct: 45 KVKLNCEVKGNPKPHIRWKLN--GTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTA 102 Query: 504 TNILG---KAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 560 TN G E +++ D + R RRG + L C S +L+ +W+ + Sbjct: 103 TNSFGTIVSREAKLQFAYLDNFKT-RTRSTVSVRRGQGMVLLCG-PPPHSGELSYAWIFN 160 Query: 561 DEPLYIGNR--MKKEDDSLTIFGVAERDQGSYTCVAS 595 + P Y NR + +E +L I V + D G+YTCV + Sbjct: 161 EYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVT 197 >gi|4827022 contactin 2 precursor [Homo sapiens] Length = 1040 Score = 226 bits (576), Expect = 5e-59 Identities = 174/571 (30%), Positives = 251/571 (43%), Gaps = 35/571 (6%) Query: 57 DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEY 116 + +L+ C A+ +P ++ W N + +P + G LVI + G Y Sbjct: 55 EQVLLACRARASPPATYRWKMNGTEMKL--EPGSRHQLVGGNLVI---MNPTKAQDAGVY 109 Query: 117 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWM 176 QC A N GT +S L+ + KE DPV EG + L CNPP P W+ Sbjct: 110 QCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWL 169 Query: 177 SSSMEPI--TQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQK-NPFTLKV 233 + T + G+LY + D+ +YSC A H + + + F Sbjct: 170 LNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLG-NYSCLATSHMDFSTKSVFSKFAQLN 228 Query: 234 LTTRGVAERTPSFM--YPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDK 291 L PS +P T + L G + LEC A G P P I W K G L Sbjct: 229 LAAEDTRLFAPSIKARFPAETYA----LVGQQVTLECFAFGNPVPRIKWRKVDGSL---S 281 Query: 292 AKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR--VKAAPYWLDEPKNLILA 349 ++ L+I +VS ED G Y C A N G R T+ R V+A P WL + Sbjct: 282 PQWTTAEPTLQIPSVSFEDEGTYECEAENSKG--RDTVQGRIIVQAQPEWLKVISDTEAD 339 Query: 350 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 409 G + R C A G P+PTV+W+ NGEPL S N +AGD + F + +YQC Sbjct: 340 IGSNLRWGCAAAGKPRPTVRWLRNGEPLASQ--NRVEVLAGD-LRFSKLSLEDSGMYQCV 396 Query: 410 TSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNG 468 N+HG + A+A ++V + P L+P +LI + C +P + W K G Sbjct: 397 AENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSK-G 455 Query: 469 QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP 528 ++ V +G+L I+ I + D+G YTC A N +GKA + L V+D T+I P Sbjct: 456 TEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAP 515 Query: 529 EDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL--------YIGNRMKKEDDSLTIF 580 G + L+C HDP++ LT +W DD P+ Y +K+ LTI Sbjct: 516 SSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTIL 575 Query: 581 GVAERDQGSYTCVASTELDQDLAKAYLTVLG 611 R G YTC+A T +D +A + V G Sbjct: 576 NAQLRHGGKYTCMAQTVVDSASKEATVLVRG 606 Score = 83.2 bits (204), Expect = 7e-16 Identities = 92/392 (23%), Positives = 160/392 (40%), Gaps = 41/392 (10%) Query: 245 SFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDL---PSDKAKFENFNKAL 301 S ++P+ + Q+ LL C A P W G ++ P + + N + Sbjct: 45 SVLFPEESTEEQV-------LLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVI 97 Query: 302 RITNVSEEDSGEYFCLASNKMGSI--RHTISVRVKAAPYWLDEPKNLILA-PGEDGRLVC 358 + +D+G Y CLASN +G++ R I +R + E ++ + A G L C Sbjct: 98 -MNPTKAQDAGVYQCLASNPVGTVVSREAI-LRFGFLQEFSKEERDPVKAHEGWGVMLPC 155 Query: 359 RANGN-PKPTVQWMVNGEPLQSAPPNPNREVAGDT---IIFRDTQISSRAVYQCNTSNEH 414 + P + +W++N P + P R T + T S Y C ++ Sbjct: 156 NPPAHYPGLSYRWLLNEFP--NFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHM 213 Query: 415 GYLLANAF-----VSVLDVPPRMLSPRNQL-----IRVILYNRTRLDCPFFGSPIPTLRW 464 + + F +++ R+ +P + ++ + L+C FG+P+P ++W Sbjct: 214 DFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKW 273 Query: 465 FKNGQGSNLDGGNYHVYENG--SLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPT 522 K +DG + +L+I + ED+G Y C A N G+ Q R+ V+ Sbjct: 274 RK------VDGSLSPQWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQP 327 Query: 523 RIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGV 582 ++ D A G+ ++ C P + TV WL++ EPL NR++ L + Sbjct: 328 EWLKVISDTEADIGSNLRWGCAAAGKP--RPTVRWLRNGEPLASQNRVEVLAGDLRFSKL 385 Query: 583 AERDQGSYTCVASTELDQDLAKAYLTVLGNCP 614 + D G Y CVA + A A L V P Sbjct: 386 SLEDSGMYQCVAENKHGTIYASAELAVQALAP 417 Score = 72.4 bits (176), Expect = 1e-12 Identities = 88/337 (26%), Positives = 125/337 (37%), Gaps = 59/337 (17%) Query: 50 DHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRP 109 D D N+ C A G P P+ W RN +P S + R L D R Sbjct: 335 DTEADIGSNLRWGCAAAGKPRPTVRWLRNG-------EPLAS-QNRVEVLAGDLRFSKLS 386 Query: 110 EEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV----VVQEGAPLTLQCNPP 165 E G YQC A NK GT ++ +++ L P L+PV G + + C P Sbjct: 387 LEDSGMYQCVAENKHGTIYAS---AELAVQALAPDFRLNPVRRLIPAARGGEILIPCQ-P 442 Query: 166 PGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQ 225 P V+ W S E + RV+ +G L N+ D + Y+C F Sbjct: 443 RAAPKAVVLW-SKGTEILVNSSRVTVTPDGTLIIRNISRSD-EGKYTC-----FAENFMG 495 Query: 226 KNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGG 285 K T +L+ R + T + SS + G +L L+C AS PT D+ + Sbjct: 496 KANST-GILSVRDATKITLA-------PSSADINLGDNLTLQCHASHDPTMDLTFTWTLD 547 Query: 286 DLPSDKAKFENFNKALRITNVSE------------EDSGEYFCLASNKMGSIRHTISVRV 333 D P D F+ R TNV E G+Y C+A + S +V V Sbjct: 548 DFPID---FDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLV 604 Query: 334 KAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQW 370 + PG G +V R G+ + W Sbjct: 605 RG-------------PPGPPGGVVVRDIGDTTIQLSW 628 >gi|75709184 contactin 3 [Homo sapiens] Length = 1028 Score = 224 bits (571), Expect = 2e-58 Identities = 172/624 (27%), Positives = 267/624 (42%), Gaps = 49/624 (7%) Query: 8 PWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHI-VDPRDN-ILIECEA 65 PW L + LGG + L Q P K+ + V D I + CEA Sbjct: 4 PWKQLILLSFIGCLGGEL-----------LLQGPVFIKEPSNSIFPVGSEDKKITLHCEA 52 Query: 66 KGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFG 125 +GNP+P + W N +++ + R + G LV+ G YQCFA N G Sbjct: 53 RGNPSPHYRWQLNGSDIDMSMEHRYKLN--GGNLVV---INPNRNWDTGTYQCFATNSLG 107 Query: 126 TALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQ 185 T +S +LQ + + + V V+EG + L C PPP W+ + + Sbjct: 108 TIVSREAKLQFAYLENFKTKMRSTVSVREGQGVVLLCGPPPHSGELSYAWIFNEYPSFVE 167 Query: 186 D--KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHT--IQQKNPFTLKVLTTRGVAE 241 + +R G LY S V D+ +Y+C T+ + P L+ G E Sbjct: 168 EDSRRFVSQETGHLYISKVEPSDVG-NYTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYE 226 Query: 242 RTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKAL 301 +P+ ++ +G + LEC A G P P I W + G S K K F+ L Sbjct: 227 PKIEVQFPETLPAA----KGSTVKLECFALGNPIPQINWRRSDGLPFSSKIKLRKFSGVL 282 Query: 302 RITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRAN 361 I N +ED+G Y C+A N G + A P+W+ K++ +A + CRA+ Sbjct: 283 EIPNFQQEDAGSYECIAENSRGKNVARGRLTYYAKPHWVQLIKDVEIAVEDSLYWECRAS 342 Query: 362 GNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANA 421 G PKP+ +W+ NG L ++ + + ++ ++QC N+HG + ++A Sbjct: 343 GKPKPSYRWLKNGAALVL---EERTQIENGALTISNLSVTDSGMFQCIAENKHGLVYSSA 399 Query: 422 FVSVL-DVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV 480 + V+ P +P +L++V + + LDC SP W K G S + + Sbjct: 400 ELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKPRASPRALSSW-KKGDVSVQEHERISL 458 Query: 481 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 540 +G L+I + K D G YTC+A N GKA L V +PTRI P + G +V Sbjct: 459 LNDGGLKIANVTKADAGTYTCMAENQFGKANGTTHLVVTEPTRITLAPSNMDVSVGESVI 518 Query: 541 LECRVKHDPSLKLTVSW--------LKDDEPLYIGNRMKKEDDS----LTIFGVAERDQG 588 L C+V+HDP L + +W K D G+ +K S L I + + G Sbjct: 519 LPCQVQHDPLLDIIFTWYFNGALADFKKD-----GSHFEKVGGSSSGDLMIRNIQLKHSG 573 Query: 589 SYTCVASTELDQDLAKAYLTVLGN 612 Y C+ T +D + A L V G+ Sbjct: 574 KYVCMVQTGVDSVSSAADLIVRGS 597 Score = 81.6 bits (200), Expect = 2e-15 Identities = 81/301 (26%), Positives = 128/301 (42%), Gaps = 33/301 (10%) Query: 46 QSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 105 Q KD + D++ EC A G P PS+ W +N + + ++ +G L I S Sbjct: 322 QLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVLEERTQIE----NGALTISNLS 377 Query: 106 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVV-VQEGAPLTLQCNP 164 G +QC A NK G S+ V+ +P + K + +V VQ G+ ++L C P Sbjct: 378 ----VTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKP 433 Query: 165 PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQ 224 P + W + + + +R+S ++G L +NV D T Y+C A F Sbjct: 434 RAS-PRALSSWKKGDVS-VQEHERISLLNDGGLKIANVTKADAGT-YTCMAENQFG---- 486 Query: 225 QKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDI--AWYK 282 + N T V+T E T + P S+ V G ++L C P DI WY Sbjct: 487 KANGTTHLVVT-----EPTRITLAP----SNMDVSVGESVILPCQVQHDPLLDIIFTWYF 537 Query: 283 KGG--DLPSDKAKFENFNKA----LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAA 336 G D D + FE + L I N+ + SG+Y C+ + S+ + V+ + Sbjct: 538 NGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSSAADLIVRGS 597 Query: 337 P 337 P Sbjct: 598 P 598 Score = 79.0 bits (193), Expect = 1e-14 Identities = 89/378 (23%), Positives = 154/378 (40%), Gaps = 42/378 (11%) Query: 264 LLLECIASGVPTPDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEE-DSGEYFCLASNK 321 + L C A G P+P W G D+ S + +++ L + N + D+G Y C A+N Sbjct: 46 ITLHCEARGNPSPHYRWQLNGSDIDMSMEHRYKLNGGNLVVINPNRNWDTGTYQCFATNS 105 Query: 322 MGSIRHTISVRVKAAPYWLDEPKNLI-----LAPGEDGRLVCRANGNPKP-----TVQWM 371 +G+I +S K +L+ K + + G+ L+C P P + W+ Sbjct: 106 LGTI---VSREAKLQFAYLENFKTKMRSTVSVREGQGVVLLC----GPPPHSGELSYAWI 158 Query: 372 VNGEPLQSAPPNPNREVAGDT--IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVP 429 N P + R V+ +T + + S Y C ++ ++ NA V P Sbjct: 159 FNEYP-SFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCVVTS----MVTNARVLGSPTP 213 Query: 430 -------------PRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGG 476 P++ + + + +L+C G+PIP + W + G Sbjct: 214 LVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQINW-RRSDGLPFSSK 272 Query: 477 NYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRG 536 +G LEI ++ED G Y C+A N GK + RL ++ +D Sbjct: 273 IKLRKFSGVLEIPNFQQEDAGSYECIAENSRGKNVARGRLTYYAKPHWVQLIKDVEIAVE 332 Query: 537 TTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVAST 596 ++ ECR P K + WLK+ L + R + E+ +LTI ++ D G + C+A Sbjct: 333 DSLYWECRASGKP--KPSYRWLKNGAALVLEERTQIENGALTISNLSVTDSGMFQCIAEN 390 Query: 597 ELDQDLAKAYLTVLGNCP 614 + + A L V+ + P Sbjct: 391 KHGLVYSSAELKVVASAP 408 >gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens] Length = 1018 Score = 219 bits (559), Expect = 4e-57 Identities = 174/571 (30%), Positives = 250/571 (43%), Gaps = 47/571 (8%) Query: 59 ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYE--GEY 116 + + C A+ +P P + W N+ ++ D R SM G LVI+ P++ + G Y Sbjct: 61 VSLNCRARASPFPVYKWRMNNGDVDLTSD-RYSMV--GGNLVIN-----NPDKQKDAGIY 112 Query: 117 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIF-W 175 C A N +G S L +P E V V+EG + L C+PP P + + W Sbjct: 113 YCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRW 172 Query: 176 MSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLK 232 + + IT DKR VSQ NG+LY +NV D + +YSC F + K Sbjct: 173 LLNEFPVFITMDKRRFVSQT-NGNLYIANVEASD-KGNYSC-----FVSSPSITKSVFSK 225 Query: 233 VLTTRGVAERTPSFMYPQGTA---SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 289 + + ERT YP L G ++ LEC A G P PDI W K +PS Sbjct: 226 FIPLIPIPERTTK-PYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPS 284 Query: 290 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 349 A+ L+I N+ ED G Y C A N G +H + V+A P W++ + + Sbjct: 285 T-AEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVD 343 Query: 350 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 409 G D C A G P PT++W+ NG G+ ++ D + +YQC Sbjct: 344 IGSDLYWPCVATGKPIPTIRWLKNGYAYHK----------GELRLY-DVTFENAGMYQCI 392 Query: 410 TSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNG 468 N +G + ANA + +L + P ++P + I R ++C +P P W K G Sbjct: 393 AENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSK-G 451 Query: 469 QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP 528 ++ ++E+GSLEI I + D GIYTC A N GKA + L + DPTRI P Sbjct: 452 TEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAP 511 Query: 529 EDQVARRGTTVQLECRVKHDPSLKLTVSW--------LKDDEPLYIGNRMKKEDDSLTIF 580 + G ++C DP+L LT W + Y N M + L I Sbjct: 512 INADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIR 571 Query: 581 GVAERDQGSYTCVASTELDQDLAKAYLTVLG 611 + G YTC A T +D A A L V G Sbjct: 572 NAQLKHAGRYTCTAQTIVDNSSASADLVVRG 602 Score = 83.6 bits (205), Expect = 5e-16 Identities = 88/365 (24%), Positives = 149/365 (40%), Gaps = 30/365 (8%) Query: 266 LECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEE-DSGEYFCLASNKMGS 324 L C A P P W GD+ ++ L I N ++ D+G Y+CLASN G Sbjct: 63 LNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNYGM 122 Query: 325 IRHTISVRVKAA--PYWLDEPKNLILAPGEDGRLVCRANGN--PKPTVQWMVNGEPLQSA 380 +R T + P+ +E + + G+ L+C + + +W++N P+ Sbjct: 123 VRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPV-FI 181 Query: 381 PPNPNREVA--GDTIIFRDTQISSRAVYQCNTSNEH-GYLLANAFVSVLDVPPRMLSPRN 437 + R V+ + + + S + Y C S+ + + F+ ++ +P R P Sbjct: 182 TMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYP 241 Query: 438 QLIRV-------ILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGS-LEIK 489 I V ++ L+C G+P+P +RW K + + +G+ L+I Sbjct: 242 ADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMP---STAEISTSGAVLKIF 298 Query: 490 MIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDP 549 I+ ED+GIY C A NI GK ++Q R+ V+ D G+ + C P Sbjct: 299 NIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKP 358 Query: 550 SLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609 T+ WLK+ + G L ++ V + G Y C+A A A L + Sbjct: 359 IP--TIRWLKNGYAYHKGE--------LRLYDVTFENAGMYQCIAENTYGAIYANAELKI 408 Query: 610 LGNCP 614 L P Sbjct: 409 LALAP 413 Score = 79.0 bits (193), Expect = 1e-14 Identities = 110/472 (23%), Positives = 179/472 (37%), Gaps = 59/472 (12%) Query: 72 SFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNR 131 S+ W N I D R + + +G L I +G Y CF + T + Sbjct: 169 SYRWLLNEFPVFITMDKRRFVSQTNGNLYI----ANVEASDKGNYSCFVSSPSIT--KSV 222 Query: 132 IRLQVSKSPLWPKENLDP----VVVQ-------EGAPLTLQCNPPPGLPSPVIFWMSSSM 180 + P+ P+ P +VVQ G +TL+C G P P I W + Sbjct: 223 FSKFIPLIPI-PERTTKPYPADIVVQFKDVYALMGQNVTLECFAL-GNPVPDIRWRKV-L 279 Query: 181 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA 240 EP+ +S L N+ L+D + Y C A I+ K+ ++ Sbjct: 280 EPMPSTAEISTS-GAVLKIFNIQLED-EGIYECEAE-----NIRGKDKHQARIYV----- 327 Query: 241 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA 300 + P ++ + G DL C+A+G P P I W K G + Sbjct: 328 QAFPEWVEHINDTEVDI---GSDLYWPCVATGKPIPTIRWLKNG---------YAYHKGE 375 Query: 301 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA-APYWLDEPKNLILAPGEDGRLV-- 357 LR+ +V+ E++G Y C+A N G+I +++ A AP + P + + GR++ Sbjct: 376 LRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIE 435 Query: 358 CRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGD--TIIFRDTQISSRAVYQCNTSNEHG 415 C+ PKP W E L N +R + + ++ + + +Y C N G Sbjct: 436 CKPKAAPKPKFSWSKGTEWLV----NSSRILIWEDGSLEINNITRNDGGIYTCFAENNRG 491 Query: 416 YLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDG 475 + + + D +L+P N I V + F + T W NG + + Sbjct: 492 KANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNK 551 Query: 476 GNYHVYEN------GSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDP 521 N H N G L I+ + + G YTC A I+ + L V+ P Sbjct: 552 ENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGP 603 Score = 76.3 bits (186), Expect = 8e-14 Identities = 89/383 (23%), Positives = 141/383 (36%), Gaps = 46/383 (12%) Query: 40 PPTITKQSAKDHIVDPRD-------NILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSM 92 P TK D +V +D N+ +EC A GNP P W + + P + Sbjct: 233 PERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRK-----VLEPMPSTAE 287 Query: 93 RRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVV 152 SG ++ F E EG Y+C A N G ++ R+ V P W E+++ V Sbjct: 288 ISTSGAVLKIFNI---QLEDEGIYECEAENIRGKD-KHQARIYVQAFPEW-VEHINDTEV 342 Query: 153 QEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYS 212 G+ L C G P P I W+ K H G+L +V ++ Y Sbjct: 343 DIGSDLYWPC-VATGKPIPTIRWL----------KNGYAYHKGELRLYDVTFENAGM-YQ 390 Query: 213 CNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASG 272 C A + LK+L E P + +G +++EC Sbjct: 391 CIAENTYGAIYANAE---LKILALAPTFEMNP-------MKKKILAAKGGRVIIECKPKA 440 Query: 273 VPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR 332 P P +W K L + + +L I N++ D G Y C A N G T ++ Sbjct: 441 APKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLV 500 Query: 333 VKAAPYWLDEPKNLILAPGEDGRLVCRANGNP--KPTVQWMVNGEPLQSAPPNPNRE--- 387 + + P N + GE+ + C A+ +P T W NG + N + + Sbjct: 501 ITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNF 560 Query: 388 --VAGDTIIFRDTQISSRAVYQC 408 + ++ R+ Q+ Y C Sbjct: 561 MLDSNGELLIRNAQLKHAGRYTC 583 Score = 50.8 bits (120), Expect = 4e-06 Identities = 40/160 (25%), Positives = 69/160 (43%), Gaps = 8/160 (5%) Query: 444 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 503 L + L+C SP P +W N +L Y + + +++D GIY C+A Sbjct: 57 LEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLA 116 Query: 504 TNILG---KAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 560 +N G E + DP PE +V + G + L C + L+ WL + Sbjct: 117 SNNYGMVRSTEATLSFGYLDPFPPEERPEVRV-KEGKGMVLLCDPPYHFPDDLSYRWLLN 175 Query: 561 DEPLYI----GNRMKKEDDSLTIFGVAERDQGSYTCVAST 596 + P++I + + + +L I V D+G+Y+C S+ Sbjct: 176 EFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSS 215 >gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens] Length = 1007 Score = 219 bits (559), Expect = 4e-57 Identities = 174/571 (30%), Positives = 250/571 (43%), Gaps = 47/571 (8%) Query: 59 ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYE--GEY 116 + + C A+ +P P + W N+ ++ D R SM G LVI+ P++ + G Y Sbjct: 50 VSLNCRARASPFPVYKWRMNNGDVDLTSD-RYSMV--GGNLVIN-----NPDKQKDAGIY 101 Query: 117 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIF-W 175 C A N +G S L +P E V V+EG + L C+PP P + + W Sbjct: 102 YCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRW 161 Query: 176 MSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLK 232 + + IT DKR VSQ NG+LY +NV D + +YSC F + K Sbjct: 162 LLNEFPVFITMDKRRFVSQT-NGNLYIANVEASD-KGNYSC-----FVSSPSITKSVFSK 214 Query: 233 VLTTRGVAERTPSFMYPQGTA---SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 289 + + ERT YP L G ++ LEC A G P PDI W K +PS Sbjct: 215 FIPLIPIPERTTK-PYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPS 273 Query: 290 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 349 A+ L+I N+ ED G Y C A N G +H + V+A P W++ + + Sbjct: 274 T-AEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVD 332 Query: 350 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 409 G D C A G P PT++W+ NG G+ ++ D + +YQC Sbjct: 333 IGSDLYWPCVATGKPIPTIRWLKNGYAYHK----------GELRLY-DVTFENAGMYQCI 381 Query: 410 TSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNG 468 N +G + ANA + +L + P ++P + I R ++C +P P W K G Sbjct: 382 AENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSK-G 440 Query: 469 QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP 528 ++ ++E+GSLEI I + D GIYTC A N GKA + L + DPTRI P Sbjct: 441 TEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAP 500 Query: 529 EDQVARRGTTVQLECRVKHDPSLKLTVSW--------LKDDEPLYIGNRMKKEDDSLTIF 580 + G ++C DP+L LT W + Y N M + L I Sbjct: 501 INADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIR 560 Query: 581 GVAERDQGSYTCVASTELDQDLAKAYLTVLG 611 + G YTC A T +D A A L V G Sbjct: 561 NAQLKHAGRYTCTAQTIVDNSSASADLVVRG 591 Score = 83.6 bits (205), Expect = 5e-16 Identities = 88/365 (24%), Positives = 149/365 (40%), Gaps = 30/365 (8%) Query: 266 LECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEE-DSGEYFCLASNKMGS 324 L C A P P W GD+ ++ L I N ++ D+G Y+CLASN G Sbjct: 52 LNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNYGM 111 Query: 325 IRHTISVRVKAA--PYWLDEPKNLILAPGEDGRLVCRANGN--PKPTVQWMVNGEPLQSA 380 +R T + P+ +E + + G+ L+C + + +W++N P+ Sbjct: 112 VRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPV-FI 170 Query: 381 PPNPNREVA--GDTIIFRDTQISSRAVYQCNTSNEH-GYLLANAFVSVLDVPPRMLSPRN 437 + R V+ + + + S + Y C S+ + + F+ ++ +P R P Sbjct: 171 TMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYP 230 Query: 438 QLIRV-------ILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGS-LEIK 489 I V ++ L+C G+P+P +RW K + + +G+ L+I Sbjct: 231 ADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMP---STAEISTSGAVLKIF 287 Query: 490 MIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDP 549 I+ ED+GIY C A NI GK ++Q R+ V+ D G+ + C P Sbjct: 288 NIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKP 347 Query: 550 SLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609 T+ WLK+ + G L ++ V + G Y C+A A A L + Sbjct: 348 IP--TIRWLKNGYAYHKGE--------LRLYDVTFENAGMYQCIAENTYGAIYANAELKI 397 Query: 610 LGNCP 614 L P Sbjct: 398 LALAP 402 Score = 79.0 bits (193), Expect = 1e-14 Identities = 110/472 (23%), Positives = 179/472 (37%), Gaps = 59/472 (12%) Query: 72 SFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNR 131 S+ W N I D R + + +G L I +G Y CF + T + Sbjct: 158 SYRWLLNEFPVFITMDKRRFVSQTNGNLYI----ANVEASDKGNYSCFVSSPSIT--KSV 211 Query: 132 IRLQVSKSPLWPKENLDP----VVVQ-------EGAPLTLQCNPPPGLPSPVIFWMSSSM 180 + P+ P+ P +VVQ G +TL+C G P P I W + Sbjct: 212 FSKFIPLIPI-PERTTKPYPADIVVQFKDVYALMGQNVTLECFAL-GNPVPDIRWRKV-L 268 Query: 181 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA 240 EP+ +S L N+ L+D + Y C A I+ K+ ++ Sbjct: 269 EPMPSTAEISTS-GAVLKIFNIQLED-EGIYECEAE-----NIRGKDKHQARIYV----- 316 Query: 241 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA 300 + P ++ + G DL C+A+G P P I W K G + Sbjct: 317 QAFPEWVEHINDTEVDI---GSDLYWPCVATGKPIPTIRWLKNG---------YAYHKGE 364 Query: 301 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA-APYWLDEPKNLILAPGEDGRLV-- 357 LR+ +V+ E++G Y C+A N G+I +++ A AP + P + + GR++ Sbjct: 365 LRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIE 424 Query: 358 CRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGD--TIIFRDTQISSRAVYQCNTSNEHG 415 C+ PKP W E L N +R + + ++ + + +Y C N G Sbjct: 425 CKPKAAPKPKFSWSKGTEWLV----NSSRILIWEDGSLEINNITRNDGGIYTCFAENNRG 480 Query: 416 YLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDG 475 + + + D +L+P N I V + F + T W NG + + Sbjct: 481 KANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNK 540 Query: 476 GNYHVYEN------GSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDP 521 N H N G L I+ + + G YTC A I+ + L V+ P Sbjct: 541 ENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGP 592 Score = 76.3 bits (186), Expect = 8e-14 Identities = 89/383 (23%), Positives = 141/383 (36%), Gaps = 46/383 (12%) Query: 40 PPTITKQSAKDHIVDPRD-------NILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSM 92 P TK D +V +D N+ +EC A GNP P W + + P + Sbjct: 222 PERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRK-----VLEPMPSTAE 276 Query: 93 RRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVV 152 SG ++ F E EG Y+C A N G ++ R+ V P W E+++ V Sbjct: 277 ISTSGAVLKIFNI---QLEDEGIYECEAENIRGKD-KHQARIYVQAFPEW-VEHINDTEV 331 Query: 153 QEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYS 212 G+ L C G P P I W+ K H G+L +V ++ Y Sbjct: 332 DIGSDLYWPC-VATGKPIPTIRWL----------KNGYAYHKGELRLYDVTFENAGM-YQ 379 Query: 213 CNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASG 272 C A + LK+L E P + +G +++EC Sbjct: 380 CIAENTYGAIYANAE---LKILALAPTFEMNP-------MKKKILAAKGGRVIIECKPKA 429 Query: 273 VPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR 332 P P +W K L + + +L I N++ D G Y C A N G T ++ Sbjct: 430 APKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLV 489 Query: 333 VKAAPYWLDEPKNLILAPGEDGRLVCRANGNP--KPTVQWMVNGEPLQSAPPNPNRE--- 387 + + P N + GE+ + C A+ +P T W NG + N + + Sbjct: 490 ITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNF 549 Query: 388 --VAGDTIIFRDTQISSRAVYQC 408 + ++ R+ Q+ Y C Sbjct: 550 MLDSNGELLIRNAQLKHAGRYTC 572 Score = 50.8 bits (120), Expect = 4e-06 Identities = 40/160 (25%), Positives = 69/160 (43%), Gaps = 8/160 (5%) Query: 444 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 503 L + L+C SP P +W N +L Y + + +++D GIY C+A Sbjct: 46 LEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLA 105 Query: 504 TNILG---KAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 560 +N G E + DP PE +V + G + L C + L+ WL + Sbjct: 106 SNNYGMVRSTEATLSFGYLDPFPPEERPEVRV-KEGKGMVLLCDPPYHFPDDLSYRWLLN 164 Query: 561 DEPLYI----GNRMKKEDDSLTIFGVAERDQGSYTCVAST 596 + P++I + + + +L I V D+G+Y+C S+ Sbjct: 165 EFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSS 204 >gi|7657361 contactin 6 [Homo sapiens] Length = 1028 Score = 198 bits (503), Expect = 1e-50 Identities = 155/568 (27%), Positives = 238/568 (41%), Gaps = 26/568 (4%) Query: 56 RDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGE 115 + +++ C A G P+P + W +N + R G+L I+ ++ G Sbjct: 43 KSEVILNCAANGYPSPHYRWKQNGTDIDFTMS--YHYRLDGGSLAIN---SPHTDQDIGM 97 Query: 116 YQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFW 175 YQC A N GT LS + +LQ + + + V V+EG + L C PPP W Sbjct: 98 YQCLATNLLGTILSRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLCGPPPHFGDLSYAW 157 Query: 176 MSSSMEPITQD--KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKV 233 + Q+ +R G+LY + V D+ +Y+C Q P L Sbjct: 158 TFNDNPLYVQEDNRRFVSQETGNLYIAKVEPSDVG-NYTCFITNKEAQRSVQGPPTPLVQ 216 Query: 234 LTTRGVAERTPSF--MYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDK 291 T + E P +P+ ++ + + LEC A G P PDI+W + G K Sbjct: 217 RTDGVMGEYEPKIEVRFPETIQAA----KDSSVKLECFALGNPVPDISWRRLDGSPLPGK 272 Query: 292 AKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPG 351 K+ L I N +ED G Y C+ASN G + A P W + +N L+ Sbjct: 273 VKYSKSQAILEIPNFQQEDEGFYECIASNLRGRNLAKGQLIFYAPPEWEQKIQNTHLSIY 332 Query: 352 EDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTS 411 ++ C+A+G P P W+ NGE L P ++ T+I +S VYQC Sbjct: 333 DNLLWECKASGKPNPWYTWLKNGERLN---PEERIQIENGTLIITMLNVSDSGVYQCAAE 389 Query: 412 NEHGYLLANAFVSVL-DVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQG 470 N++ + ANA + VL P SP + V + + C P + W K G Sbjct: 390 NKYQIIYANAELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISW-KRGTE 448 Query: 471 SNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPED 530 + + E+GSL+I I + D G YTC+ATN G A+N L VK+ T I P Sbjct: 449 TLRQSKRIFLLEDGSLKIYNITRSDAGSYTCIATNQFGTAKNTGSLIVKERTVITVPPSK 508 Query: 531 QVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK-------KEDDSLTIFGVA 583 G ++ L C+V HDPS+++ W + + + + + + L I + Sbjct: 509 MDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQ 568 Query: 584 ERDQGSYTCVASTELDQDLAKAYLTVLG 611 G Y C T L+ A A + V G Sbjct: 569 LHHSGKYLCTVQTTLESLSAVADIIVRG 596 Score = 90.9 bits (224), Expect = 3e-18 Identities = 93/377 (24%), Positives = 156/377 (41%), Gaps = 38/377 (10%) Query: 263 DLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNV--SEEDSGEYFCLASN 320 +++L C A+G P+P W + G D+ + + N +++D G Y CLA+N Sbjct: 45 EVILNCAANGYPSPHYRWKQNGTDIDFTMSYHYRLDGGSLAINSPHTDQDIGMYQCLATN 104 Query: 321 KMGSIRHTISVRVKAAPYWLD--EPKNLILAPGEDGRLVCRANGNPKP----TVQWMVNG 374 +G+I +S + K +++ E K +G+ V G P + W N Sbjct: 105 LLGTI---LSRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLCGPPPHFGDLSYAWTFND 161 Query: 375 EPLQSAPPNPNREVAGDT--IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVL------ 426 PL N R V+ +T + + S Y C +N+ + L Sbjct: 162 NPLYVQEDN-RRFVSQETGNLYIAKVEPSDVGNYTCFITNKEAQRSVQGPPTPLVQRTDG 220 Query: 427 ---DVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYEN 483 + P++ + I+ + +L+C G+P+P + W + GS L G + Sbjct: 221 VMGEYEPKIEVRFPETIQAAKDSSVKLECFALGNPVPDISW-RRLDGSPLPGKVKYSKSQ 279 Query: 484 GSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQL-- 541 LEI ++ED+G Y C+A+N+ G R K Y PE + + T + + Sbjct: 280 AILEIPNFQQEDEGFYECIASNLRG------RNLAKGQLIFYAPPEWEQKIQNTHLSIYD 333 Query: 542 ----ECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTE 597 EC+ P+ T WLK+ E L R++ E+ +L I + D G Y C A + Sbjct: 334 NLLWECKASGKPNPWYT--WLKNGERLNPEERIQIENGTLIITMLNVSDSGVYQCAAENK 391 Query: 598 LDQDLAKAYLTVLGNCP 614 A A L VL + P Sbjct: 392 YQIIYANAELRVLASAP 408 Score = 79.3 bits (194), Expect = 9e-15 Identities = 82/295 (27%), Positives = 119/295 (40%), Gaps = 43/295 (14%) Query: 57 DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEY 116 DN+L EC+A G P P + W +N N P ++ +GTL+I + G Y Sbjct: 333 DNLLWECKASGKPNPWYTWLKNGERLN----PEERIQIENGTLIITMLNVSD----SGVY 384 Query: 117 QCFARNKFGTALSN-RIRL-----QVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPS 170 QC A NK+ +N +R+ SKSP+ K VQ G + + C P P Sbjct: 385 QCAAENKYQIIYANAELRVLASAPDFSKSPVKKKS-----FVQVGGDIVIGCKPN-AFPR 438 Query: 171 PVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFT 230 I W + E + Q KR+ +G L N+ D + Y+C A F T Sbjct: 439 AAISWKRGT-ETLRQSKRIFLLEDGSLKIYNITRSDAGS-YTCIATNQFG---------T 487 Query: 231 LKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIA--WYKKGG--D 286 K + V ERT + P S V G ++L C S P+ ++ W+ G D Sbjct: 488 AKNTGSLIVKERTVITVPP----SKMDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVID 543 Query: 287 LPSDKAKFENFNKA----LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAP 337 L A FE L I N+ SG+Y C + S+ + V+ P Sbjct: 544 LKKGVAHFERIGGESVGDLMIRNIQLHHSGKYLCTVQTTLESLSAVADIIVRGPP 598 >gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform ROBO2b [Homo sapiens] Length = 1378 Score = 194 bits (494), Expect = 2e-49 Identities = 156/518 (30%), Positives = 232/518 (44%), Gaps = 35/518 (6%) Query: 19 LSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRN 78 L L G + + +D S + PP I + + D IV + + C+A+G P P+ W ++ Sbjct: 9 LLLCGFLYVRVDGSRLRQEDFPPRIVEHPS-DVIVSKGEPTTLNCKAEGRPTPTIEWYKD 67 Query: 79 SRFFNIAKDPRVSMRRR--SGTLV-IDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQ 135 KD S R SG+L + G R + EG Y C ARN G A+S L+ Sbjct: 68 GERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLE 127 Query: 136 VSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNG 195 V+ ++N VVV G P L+C PP G P P I+W + +++R+S G Sbjct: 128 VALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISI-RGG 186 Query: 196 DLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASS 255 L SN D Y+C T+ + +++ ++ V ER P+F+ + Sbjct: 187 KLMISNTRKSDAGM-YTCVG----TNMVGERDSDPAELT----VFER-PTFLR---RPIN 233 Query: 256 QMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYF 315 Q+VL + C G P P + W K DLP + ++ + LRI D G Y Sbjct: 234 QVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKD-DYTLRIKKTMSTDEGTYM 292 Query: 316 CLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGE 375 C+A N++G + + ++ V+A P ++ P++ I+A G C GNP+P V W G Sbjct: 293 CIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGS 352 Query: 376 -----PLQSAPPNPNREVA--GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDV 428 P Q PN V+ GD I + Q S Y C G +LA A + V DV Sbjct: 353 QNLLFPNQPQQPNSRCSVSPTGDLTI-TNIQRSDAGYYICQALTVAGSILAKAQLEVTDV 411 Query: 429 -----PPRML-SPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYE 482 PP +L P NQ + V L C G P+P + W K G + E Sbjct: 412 LTDRPPPIILQGPANQTLAV--DGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQE 469 Query: 483 NGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKD 520 G+L+IK +R D G YTCVAT+ G+ L+V + Sbjct: 470 QGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTE 507 Score = 139 bits (349), Expect = 1e-32 Identities = 108/379 (28%), Positives = 172/379 (45%), Gaps = 31/379 (8%) Query: 254 SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNV------- 306 S +V +G L C A G PTP I WYK G + +DK + L ++ Sbjct: 38 SDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVH 97 Query: 307 ---SEEDSGEYFCLASNKMG-SIRHTISVRVKAA-PYWLDEPKNLILAPGEDGRLVCRA- 360 S+ D G Y C+A N +G ++ S+ V + P ++++A GE L C+ Sbjct: 98 GRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPP 157 Query: 361 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 420 G+P+PT+ W + ++ + G ++ +T+ S +Y C +N G ++ Sbjct: 158 RGHPEPTIYW--KKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSD 215 Query: 421 -AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYH 479 A ++V + P + P NQ+ V+ C G P PT+RW K+ ++L G Y Sbjct: 216 PAELTVFERPTFLRRPINQV--VLEEEAVEFRCQVQGDPQPTVRWKKDD--ADLPRGRYD 271 Query: 480 VYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTV 539 + ++ +L IK D+G Y C+A N +GK E L V+ P + P DQ+ +G TV Sbjct: 272 IKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTV 331 Query: 540 QLECRVKHDPSLKLTVSWLKD-DEPLYIGNRMKKEDD--------SLTIFGVAERDQGSY 590 C K +P + V W K+ + L N+ ++ + LTI + D G Y Sbjct: 332 TFPCETKGNP--QPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYY 389 Query: 591 TCVASTELDQDLAKAYLTV 609 C A T LAKA L V Sbjct: 390 ICQALTVAGSILAKAQLEV 408 Score = 135 bits (340), Expect = 1e-31 Identities = 132/505 (26%), Positives = 208/505 (41%), Gaps = 50/505 (9%) Query: 133 RLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQG 192 RL+ P E+ V+V +G P TL C G P+P I W E + DK + Sbjct: 23 RLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAE-GRPTPTIEWYKDG-ERVETDKDDPRS 80 Query: 193 H-----NGDLYFSNVM----LQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERT 243 H +G L+F ++ + + Y C AR + + + +L+V R + Sbjct: 81 HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNA--SLEVALLRDDFRQN 138 Query: 244 PSFMYPQGTASSQMVLRGMDLLLECIAS-GVPTPDIAWYKKGGDLPSDKAKFENFNKALR 302 P+ + +V G +LEC G P P I W K + + + L Sbjct: 139 PTDV---------VVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLM 189 Query: 303 ITNVSEEDSGEYFCLASNKMGSI-RHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRAN 361 I+N + D+G Y C+ +N +G + V P +L P N ++ E C+ Sbjct: 190 ISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQ 249 Query: 362 GNPKPTVQWMVNGEPLQSAPPNPNREVAGD-TIIFRDTQISSRAVYQCNTSNEHGYLLAN 420 G+P+PTV+W + L P ++ D T+ + T + Y C N G + A+ Sbjct: 250 GDPQPTVRWKKDDADL----PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEAS 305 Query: 421 AFVSVLDVPPRMLSPRNQLIRVILYNRT-RLDCPFFGSPIPTLRWFKNGQGSNL------ 473 A ++V P ++ PR+Q ++ RT C G+P P + W K G + L Sbjct: 306 ATLTVRAPPQFVVRPRDQ---IVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQ 362 Query: 474 -DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKD------PTRIYR 526 V G L I I++ D G Y C A + G + +LEV D P I + Sbjct: 363 QPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQ 422 Query: 527 MPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDE--PLYIGNRMKKEDDSLTIFGVAE 584 P +Q T L+C+ DP +SWLK+ P +E +L I + Sbjct: 423 GPANQTLAVDGTALLKCKATGDPLP--VISWLKEGFTFPGRDPRATIQEQGTLQIKNLRI 480 Query: 585 RDQGSYTCVASTELDQDLAKAYLTV 609 D G+YTCVA++ + A L V Sbjct: 481 SDTGTYTCVATSSSGETSWSAVLDV 505 >gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform ROBO2a [Homo sapiens] Length = 1394 Score = 192 bits (487), Expect = 1e-48 Identities = 151/497 (30%), Positives = 223/497 (44%), Gaps = 35/497 (7%) Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR--SG 97 PP I + + D IV + + C+A+G P P+ W ++ KD S R SG Sbjct: 46 PPRIVEHPS-DVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSG 104 Query: 98 TLV-IDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 156 +L + G R + EG Y C ARN G A+S L+V+ ++N VVV G Sbjct: 105 SLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGE 164 Query: 157 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 216 P L+C PP G P P I+W + +++R+S G L SN D Y+C Sbjct: 165 PAILECQPPRGHPEPTIYWKKDKVRIDDKEERISI-RGGKLMISNTRKSDAGM-YTCVG- 221 Query: 217 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 276 T+ + +++ ++ V ER P+F+ +Q+VL + C G P P Sbjct: 222 ---TNMVGERDSDPAELT----VFER-PTFLR---RPINQVVLEEEAVEFRCQVQGDPQP 270 Query: 277 DIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAA 336 + W K DLP + ++ + LRI D G Y C+A N++G + + ++ V+A Sbjct: 271 TVRWKKDDADLPRGRYDIKD-DYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP 329 Query: 337 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGE-----PLQSAPPNPNREVA-- 389 P ++ P++ I+A G C GNP+P V W G P Q PN V+ Sbjct: 330 PQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 389 Query: 390 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDV-----PPRML-SPRNQLIRVI 443 GD I + Q S Y C G +LA A + V DV PP +L P NQ + V Sbjct: 390 GDLTI-TNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAV- 447 Query: 444 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 503 L C G P+P + W K G + E G+L+IK +R D G YTCVA Sbjct: 448 -DGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVA 506 Query: 504 TNILGKAENQVRLEVKD 520 T+ G+ L+V + Sbjct: 507 TSSSGETSWSAVLDVTE 523 Score = 139 bits (349), Expect = 1e-32 Identities = 108/379 (28%), Positives = 172/379 (45%), Gaps = 31/379 (8%) Query: 254 SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNV------- 306 S +V +G L C A G PTP I WYK G + +DK + L ++ Sbjct: 54 SDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVH 113 Query: 307 ---SEEDSGEYFCLASNKMG-SIRHTISVRVKAA-PYWLDEPKNLILAPGEDGRLVCRA- 360 S+ D G Y C+A N +G ++ S+ V + P ++++A GE L C+ Sbjct: 114 GRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPP 173 Query: 361 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 420 G+P+PT+ W + ++ + G ++ +T+ S +Y C +N G ++ Sbjct: 174 RGHPEPTIYW--KKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSD 231 Query: 421 -AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYH 479 A ++V + P + P NQ+ V+ C G P PT+RW K+ ++L G Y Sbjct: 232 PAELTVFERPTFLRRPINQV--VLEEEAVEFRCQVQGDPQPTVRWKKDD--ADLPRGRYD 287 Query: 480 VYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTV 539 + ++ +L IK D+G Y C+A N +GK E L V+ P + P DQ+ +G TV Sbjct: 288 IKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTV 347 Query: 540 QLECRVKHDPSLKLTVSWLKD-DEPLYIGNRMKKEDD--------SLTIFGVAERDQGSY 590 C K +P + V W K+ + L N+ ++ + LTI + D G Y Sbjct: 348 TFPCETKGNP--QPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYY 405 Query: 591 TCVASTELDQDLAKAYLTV 609 C A T LAKA L V Sbjct: 406 ICQALTVAGSILAKAQLEV 424 Score = 135 bits (340), Expect = 1e-31 Identities = 132/505 (26%), Positives = 208/505 (41%), Gaps = 50/505 (9%) Query: 133 RLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQG 192 RL+ P E+ V+V +G P TL C G P+P I W E + DK + Sbjct: 39 RLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAE-GRPTPTIEWYKDG-ERVETDKDDPRS 96 Query: 193 H-----NGDLYFSNVM----LQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERT 243 H +G L+F ++ + + Y C AR + + + +L+V R + Sbjct: 97 HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNA--SLEVALLRDDFRQN 154 Query: 244 PSFMYPQGTASSQMVLRGMDLLLECIAS-GVPTPDIAWYKKGGDLPSDKAKFENFNKALR 302 P+ + +V G +LEC G P P I W K + + + L Sbjct: 155 PTDV---------VVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLM 205 Query: 303 ITNVSEEDSGEYFCLASNKMGSI-RHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRAN 361 I+N + D+G Y C+ +N +G + V P +L P N ++ E C+ Sbjct: 206 ISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQ 265 Query: 362 GNPKPTVQWMVNGEPLQSAPPNPNREVAGD-TIIFRDTQISSRAVYQCNTSNEHGYLLAN 420 G+P+PTV+W + L P ++ D T+ + T + Y C N G + A+ Sbjct: 266 GDPQPTVRWKKDDADL----PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEAS 321 Query: 421 AFVSVLDVPPRMLSPRNQLIRVILYNRT-RLDCPFFGSPIPTLRWFKNGQGSNL------ 473 A ++V P ++ PR+Q ++ RT C G+P P + W K G + L Sbjct: 322 ATLTVRAPPQFVVRPRDQ---IVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQ 378 Query: 474 -DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKD------PTRIYR 526 V G L I I++ D G Y C A + G + +LEV D P I + Sbjct: 379 QPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQ 438 Query: 527 MPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDE--PLYIGNRMKKEDDSLTIFGVAE 584 P +Q T L+C+ DP +SWLK+ P +E +L I + Sbjct: 439 GPANQTLAVDGTALLKCKATGDPLP--VISWLKEGFTFPGRDPRATIQEQGTLQIKNLRI 496 Query: 585 RDQGSYTCVASTELDQDLAKAYLTV 609 D G+YTCVA++ + A L V Sbjct: 497 SDTGTYTCVATSSSGETSWSAVLDV 521 Score = 40.0 bits (92), Expect = 0.006 Identities = 33/139 (23%), Positives = 61/139 (43%), Gaps = 9/139 (6%) Query: 12 AAFLLC-LLSLGGAIEIPMDPSIQNELT-QPPTITKQSAKDHIVDPRDNILIECEAKGNP 69 A + +C L++ G+I + + LT +PP I Q + + L++C+A G+P Sbjct: 402 AGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDP 461 Query: 70 APSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALS 129 P W + F +DPR +++ + + + R G Y C A + G Sbjct: 462 LPVISWLKEGFTFP-GRDPRATIQEQGTLQIKNLRISD-----TGTYTCVATSSSGETSW 515 Query: 130 NRIRLQVSKSPLWPKENLD 148 + + L V++S +N D Sbjct: 516 SAV-LDVTESGATISKNYD 533 >gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo sapiens] Length = 1386 Score = 184 bits (466), Expect = 3e-46 Identities = 151/512 (29%), Positives = 231/512 (45%), Gaps = 37/512 (7%) Query: 18 LLSLGGAIEIPMDPSIQNELTQP----PTITKQSAKDHIVDPRDNILIECEAKGNPAPSF 73 L +L + P DPS+ P P I +Q D +V + + C A+G P P+ Sbjct: 37 LAALNHTLLPPGDPSLNGSRVGPEDAMPRIVEQPP-DLLVSRGEPATLPCRAEGRPRPNI 95 Query: 74 HWTRN-SRFFNIAKDPRVS-MRRRSGTLVID-FRSGGRPEEYEGEYQCFARNKFGTALSN 130 W +N +R + +DPR + SG L G R EG Y C ARN G A S Sbjct: 96 EWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASR 155 Query: 131 RIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVS 190 L+V+ +++ VVV G P L+C PP G P P + W ++ R++ Sbjct: 156 NASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRIT 215 Query: 191 QGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQ 250 G L S+ + D Y C A ++ ++ +V+ V ER PSF+ Sbjct: 216 I-RGGKLMMSHTLKSDAGM-YVCVA----SNMAGERESAAAEVM----VLER-PSFLR-- 262 Query: 251 GTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEED 310 +Q+VL + C G P P + W K+ G+LP+ + + + + +L I +VS ED Sbjct: 263 -RPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIRS-DHSLWIGHVSAED 320 Query: 311 SGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQW 370 G Y C+A N +G + S+ V P + +P++ + APGE C GNP P + W Sbjct: 321 EGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFW 380 Query: 371 MVNGE-----PLQSAPPNPNREVAG-DTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVS 424 G P QS P V+ + Q Y C + G +LA A + Sbjct: 381 QKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLE 440 Query: 425 V----LD-VPPRMLS-PRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNY 478 + LD +PP +L P NQ + +L + L C G+P P++RW K+GQ D + Sbjct: 441 IKGASLDGLPPVILQGPANQTL--VLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQF 498 Query: 479 HVYENGSLEIKMIRKEDQGIYTCVATNILGKA 510 NG+L I +++ D G Y+CVA + G+A Sbjct: 499 KTMANGTLYIANVQEMDMGFYSCVAKSSTGEA 530 Score = 134 bits (337), Expect = 2e-31 Identities = 116/383 (30%), Positives = 160/383 (41%), Gaps = 41/383 (10%) Query: 257 MVLRGMDLLLECIASGVPTPDIAWYKKGGD--------------LPSDKAKFENFNKALR 302 +V RG L C A G P P+I WYK G LPS F R Sbjct: 74 LVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRR 133 Query: 303 ITNVSEEDSGEYFCLASNKMG---SIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVC- 358 + D G Y C+A N +G S ++ V V + P N+++A GE L C Sbjct: 134 ----ARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDF-RQSPGNVVVAVGEPAVLECV 188 Query: 359 RANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYL- 417 G+P+P+V W +G L+ + G ++ T S +Y C SN G Sbjct: 189 PPRGHPEPSVSWRKDGARLKEEEGRIT--IRGGKLMMSHTLKSDAGMYVCVASNMAGERE 246 Query: 418 LANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGN 477 A A V VL+ P + P NQ+ V+ C G P P LRW K + L G Sbjct: 247 SAAAEVMVLERPSFLRRPVNQV--VLADAPVTFLCEVKGDPPPRLRWRK--EDGELPTGR 302 Query: 478 YHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGT 537 Y + + SL I + ED+G YTCVA N +G+AE L V P ++ P+DQ+A G Sbjct: 303 YEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGE 362 Query: 538 TVQLECRVKHDPSLKLTVSWLKDDEPLYI---------GNRMKKEDDSLTIFGVAERDQG 588 +V +C K +P + W K+ + + G L I V D G Sbjct: 363 SVAFQCETKGNP--PPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAG 420 Query: 589 SYTCVASTELDQDLAKAYLTVLG 611 Y C A + LAKA L + G Sbjct: 421 YYVCQAVSVAGSILAKALLEIKG 443 Score = 128 bits (321), Expect = 2e-29 Identities = 126/495 (25%), Positives = 207/495 (41%), Gaps = 48/495 (9%) Query: 150 VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPIT--QDKRVSQG--HNGDLYFSNVM-- 203 ++V G P TL C G P P I W + T +D R + +G L+F ++ Sbjct: 73 LLVSRGEPATLPCRAE-GRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHG 131 Query: 204 --LQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRG 261 + + Y+C AR ++ +N +L+V R ++P + +V G Sbjct: 132 RRARPDEGVYTCVAR-NYLGAAASRNA-SLEVAVLRDDFRQSPG---------NVVVAVG 180 Query: 262 MDLLLECIAS-GVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASN 320 +LEC+ G P P ++W K G L ++ + L +++ + D+G Y C+ASN Sbjct: 181 EPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASN 240 Query: 321 KMGSIRHTIS-VRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQS 379 G + V V P +L P N ++ +C G+P P ++W L Sbjct: 241 MAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGEL-- 298 Query: 380 APPNPNREVAGD-TIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLS-PRN 437 P E+ D ++ Y C N G A+ +SV VPP++++ P++ Sbjct: 299 --PTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSV-HVPPQLVTQPQD 355 Query: 438 QLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL-------DGGNYHVYENGSLEIKM 490 Q+ C G+P P + W K G L G + V G L I Sbjct: 356 QMAAP--GESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITA 413 Query: 491 IRKEDQGIYTCVATNILGKAENQVRLEVKD------PTRIYRMPEDQVARRGTTVQLECR 544 +++ D G Y C A ++ G + LE+K P I + P +Q G++V L CR Sbjct: 414 VQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCR 473 Query: 545 VKHDPSLKLTVSWLKDDEPLYIGNRMKKE--DDSLTIFGVAERDQGSYTCVASTELDQDL 602 V +P + +V W KD + L + K + +L I V E D G Y+CVA + + Sbjct: 474 VTGNP--QPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEAT 531 Query: 603 AKAYLTVLGNCPCSP 617 +L + + SP Sbjct: 532 WSGWLKMREDWGVSP 546 >gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] Length = 3783 Score = 182 bits (463), Expect = 6e-46 Identities = 165/587 (28%), Positives = 246/587 (41%), Gaps = 47/587 (8%) Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTR-NSRFFNIAKDPRVSMRRRSGT 98 PPTI D V +++ C + G PAP+ W++ ++ RVS SG Sbjct: 2574 PPTIADDQT-DFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSP---SGA 2629 Query: 99 LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLW-PKENLDPVVVQEGAP 157 L I G + G Y C ARN G A + L V SP+ P ++ V +E Sbjct: 2630 LEI----GQALPIHAGRYTCSARNSAGVA-HKHVFLTVQASPVVKPLPSVVRAVAEEEVL 2684 Query: 158 LTLQCNPPPGLPSPVIFWMSSSMEPITQ-DKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 216 L + + G+P P I W + T +V G G L ++ +D +Y C A Sbjct: 2685 LPCEAS---GIPRPTITWQKEGLNVATGVSTQVLPG--GQLRIAHASPEDAG-NYLCIA- 2737 Query: 217 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 276 KN + TR V + P + G L C A G P P Sbjct: 2738 ---------KNSAGSAMGKTRLVVQVPPVI---ENGLPDLSTTEGSHAFLPCKARGSPEP 2785 Query: 277 DIAWYKKGGDLPSDKAKFE-NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 335 +I W K G + + KF + L + N+ +D+G Y C A N +G R + + + Sbjct: 2786 NITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILV 2845 Query: 336 APYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIF 395 P + P + L G+ L C A G+P P + W VN P+ + + G T+ Sbjct: 2846 LPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV---SEQDGGSTLQR 2902 Query: 396 RDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFF 455 Y C N G A +FV V + P + L+ + +LDC Sbjct: 2903 AAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPV-GGSIQLDCVVR 2961 Query: 456 GSPIPTLRWFKNG---QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAEN 512 G P+P + W K+G +GS+L H +NGSL I+ ++D G Y C+A N +G A+ Sbjct: 2962 GDPVPDIHWIKDGLPLRGSHLR----HQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKK 3017 Query: 513 QVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKK 572 V L ++ P+D R G V L C+ +P+ T+ WL+ +PL R++ Sbjct: 3018 VVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPT--PTIEWLQAGQPLRASRRLRT 3075 Query: 573 -EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGNCPCSPW 618 D SL + V D G+Y CVA L A+A+L V G P W Sbjct: 3076 LPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGE-PQGSW 3121 Score = 157 bits (396), Expect = 4e-38 Identities = 153/604 (25%), Positives = 252/604 (41%), Gaps = 55/604 (9%) Query: 41 PTI---TKQSAKDHIVDPRDN-ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96 PTI + SA + + +N I + CEA P+P+ W ++ F +++ ++ + Sbjct: 1255 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL-LPGTH 1313 Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNR-----IRLQVSKSPLWPKENLDPVV 151 G +++ + +E G+Y C N+ G A+ N I +SK + + V Sbjct: 1314 GLQILNAQ-----KEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVK 1368 Query: 152 VQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDY 211 + + LTL+C +P P I W +P+T R+ G L LQ T Sbjct: 1369 TKVNSTLTLECESW-AVPPPTIRWYKDG-QPVTPSSRLQVLGEGRL------LQIQPTQV 1420 Query: 212 SCNARFHFTHT------------IQQKNPFTLKVLTTRGVAERTPSFMYPQGTASS-QMV 258 S + R+ T + Q P KV E +G + + + Sbjct: 1421 SDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREI 1480 Query: 259 LRGMDLLLECIASGVPTPDIAWYKKGGDLPS-DKAKFENFNKALRITNVSEEDSGEYFCL 317 + L C + +P PD+ WY++ L + D+ + L+I V E++G Y C Sbjct: 1481 VENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCK 1540 Query: 318 ASNKMGSIRHTISVRVKAAPYWLDEPKNLI----LAPGEDGRLVCRANGNPKPTVQWMVN 373 ASN++G + V P L + + L+ + L C A GNP PT+ W+ N Sbjct: 1541 ASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQN 1600 Query: 374 GEPLQSAPPNPNREVAGDTIIFR--DTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPR 431 G P P+P +V D + + +++ A Y C N+ G F + VPPR Sbjct: 1601 GLPFS---PSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSA-EKLFTLRVQVPPR 1656 Query: 432 MLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMI 491 + + + IL + L C P P + W+K+ Q +L + + +L++ Sbjct: 1657 IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRA 1716 Query: 492 RKEDQGIYTCVATNILGKAENQVRLEVKDP---TRIYRMPEDQV-ARRGTTVQLECRVKH 547 R D G+YTC A N G+ + V+L V P + R P+D V R G L C Sbjct: 1717 RLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCET-- 1774 Query: 548 DPSLKLTVSWLKDDEPLYIGNRMK--KEDDSLTIFGVAERDQGSYTCVASTELDQDLAKA 605 D + TV+W KD +PL + R + + L I D+G Y+C S + + Sbjct: 1775 DALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTF 1834 Query: 606 YLTV 609 LTV Sbjct: 1835 TLTV 1838 Score = 156 bits (394), Expect = 6e-38 Identities = 152/563 (26%), Positives = 234/563 (41%), Gaps = 70/563 (12%) Query: 57 DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYE--- 113 D ++ CE P P+ W ++ + P V +R R G R E E Sbjct: 1766 DKAVLSCETDALPEPTVTWYKDGQ-------PLVLAQRTQA-----LRGGQRLEIQEAQV 1813 Query: 114 ---GEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPS 170 G Y C N G A+ L V P + + V G+PL L C+ G+P+ Sbjct: 1814 SDKGLYSCKVSNVAGEAVRT-FTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVS-GVPA 1871 Query: 171 PVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFT 230 P + W+ M + G L S + T Y+C A + + F Sbjct: 1872 PTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGT-YTCVAE---NTQAEARKDFV 1927 Query: 231 LKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSD 290 + VL VA R S G A VL G ++ L+C A G P PD+AW K G L D Sbjct: 1928 VAVL----VAPRIRS----SGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQD 1979 Query: 291 KAKFENF---NKALRITNVSEEDSGEYFCLASNKMG--SIRHTISVRV-KAAPYWLDEPK 344 F +L + + D+G Y C+A N G + HT++V V D Sbjct: 1980 MGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSG 2039 Query: 345 NLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV---AGDTIIFRDTQIS 401 L+ PGE +VC G+P V W+ +G PL P R + +G T+ Q++ Sbjct: 2040 TLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL----PLSQRTLLHGSGHTLRISKVQLA 2095 Query: 402 SRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSP---RNQLIRVILYNRTRLDCPFFGSP 458 ++ C ++ G N F + VPP +L P +N ++ V+ + L C G P Sbjct: 2096 DAGIFTCVAASPAGVADRN-FTLQVQVPP-VLEPVEFQNDVV-VVRGSLVELPCEARGVP 2152 Query: 459 IPTLRWFKNGQ---GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVR 515 +P + W K+G+ +L+ G SL+++ + D G Y+CVA + G+A + Sbjct: 2153 LPLVSWMKDGEPLLSQSLEQG-------PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQ 2205 Query: 516 LEVKDPTRI--YRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKE 573 L V +P I P + G ++L C + P +T W KD + L + E Sbjct: 2206 LTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNIT--WHKDGQAL-----TRLE 2258 Query: 574 DDSLTIFGVAERDQGSYTCVAST 596 ++S + RD G YTC+A + Sbjct: 2259 NNSRATRVLRVRDAGLYTCLAES 2281 Score = 151 bits (382), Expect = 2e-36 Identities = 149/571 (26%), Positives = 230/571 (40%), Gaps = 37/571 (6%) Query: 40 PPTI---TKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96 PP I T++ ++ V+ + ++C A GNP P+ W +N F+ PR+ + Sbjct: 1559 PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFS--PSPRLQVLEDG 1616 Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 156 L + Y C A N+ G+A L+V P +L+ V + Sbjct: 1617 QVLQVSTAEVADA----ASYMCVAENQAGSA-EKLFTLRVQVPPRIAGLDLEQVTAILNS 1671 Query: 157 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 216 ++L C+ P+P + W S ++ L L D Y+C A Sbjct: 1672 SVSLPCDVHAH-PNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGM-YTCEA- 1728 Query: 217 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMY-PQGTASSQMVLRGMDLLLECIASGVPT 275 + + L VL P+F P+G + +V G +L C +P Sbjct: 1729 --LNAAGRDQKLVQLSVLVP-------PAFRQAPRGPQDAVLVRVGDKAVLSCETDALPE 1779 Query: 276 PDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVK 334 P + WYK G L + + + + L I D G Y C SN G T ++ V+ Sbjct: 1780 PTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQ 1839 Query: 335 AAPYWLDEPKNLILA--PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT 392 P + + PK ++ G L C +G P PTV W+ + P++S+ + G Sbjct: 1840 VPPTF-ENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRL 1898 Query: 393 IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDC 452 + R Q + Y C N + V+VL P S + V+ RLDC Sbjct: 1899 QLSR-LQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC 1957 Query: 453 PFFGSPIPTLRWFKNGQGSNLDGGNY--HVYENGSLEIKMIRKEDQGIYTCVATNILGKA 510 G P P + W K+G D G + + GSL +K +R D G YTCVA N G+ Sbjct: 1958 EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED 2017 Query: 511 ENQVRLEVKDPTRIYRMPEDQ---VARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIG 567 + V P I + + V+R G V + C V+ P + VSWLKD PL + Sbjct: 2018 ARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIH--VSWLKDGLPLPLS 2075 Query: 568 NR--MKKEDDSLTIFGVAERDQGSYTCVAST 596 R + +L I V D G +TCVA++ Sbjct: 2076 QRTLLHGSGHTLRISKVQLADAGIFTCVAAS 2106 Score = 150 bits (380), Expect = 3e-36 Identities = 144/580 (24%), Positives = 228/580 (39%), Gaps = 37/580 (6%) Query: 37 LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96 L P + A++H V + ++CEA G P P W ++ P + Sbjct: 1931 LVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDG 1990 Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFG-TALSNRIRLQVSKSPLWPKENLDPVVVQEG 155 G+LV+ G G Y C A N G A + + + V + + +V + G Sbjct: 1991 GSLVLK----GLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPG 2046 Query: 156 APLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA 215 +T+ C P G P + W+ + + + G L S V L D ++C A Sbjct: 2047 ELVTMVC-PVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGI-FTCVA 2104 Query: 216 RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 275 + +N FTL+V + P + P + +V+RG + L C A GVP Sbjct: 2105 A--SPAGVADRN-FTLQV--------QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPL 2153 Query: 276 PDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 335 P ++W K G L S + +L++ V DSG Y C+A ++ G R + V Sbjct: 2154 PLVSWMKDGEPLLSQSLE---QGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVME 2210 Query: 336 APYWLD--EPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTI 393 P+ D +P L L PG L+C A G P+P + W +G+ L N Sbjct: 2211 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRAT------ 2264 Query: 394 IFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRN-QLIRVILYNRTRLDC 452 R ++ +Y C + G + +F + PP ++ PR + + + + L+C Sbjct: 2265 --RVLRVRDAGLYTCLAESPAG-AIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLEC 2321 Query: 453 PFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAEN 512 P P + W ++G D L+++ + D G Y+C A N G Sbjct: 2322 SVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSV 2381 Query: 513 QVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKK 572 R+E+ I P T L C+ P+ VSW KD PL + + Sbjct: 2382 AFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPA--PLVSWRKDRVPLDPRSPRFE 2439 Query: 573 --EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 610 + SL I V +D G Y C+AS D L VL Sbjct: 2440 ILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVL 2479 Score = 150 bits (379), Expect = 3e-36 Identities = 148/591 (25%), Positives = 237/591 (40%), Gaps = 52/591 (8%) Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 99 PP IT + V + + C A G P+P+ W ++ + A P + + L Sbjct: 694 PPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVL 753 Query: 100 VIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLD-PVVVQEGAPL 158 + + R + G Y C A + G + + LQV P E L+ VV E L Sbjct: 754 TL---ASARASD-SGRYSCVAVSAVGEDRQDVV-LQVHMPPSILGEELNVSVVANESVAL 808 Query: 159 TLQCNPPPGLPSPVIFWMSSS--MEP-----ITQDKRVSQGHNGDLYFSNVMLQDMQTDY 211 Q + +P PV+ W +EP ++ DK + Q D++ + Y Sbjct: 809 ECQSH---AMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAG--------HY 857 Query: 212 SCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIAS 271 +C A H+ + N L V ++P + + V G L C Sbjct: 858 TCEALNQAGHSEKHYN---LNVWVAP---------VFPLRESHTLTVREGHPTRLSCECR 905 Query: 272 GVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEED---SGEYFCLASNKMGSIRHT 328 GVP P I+W K G LP + A ++ + R+ + + G Y C SN +G+ Sbjct: 906 GVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQD 965 Query: 329 ISVRVKAAPYWL---DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPN 385 + + V P + P + + L C A G P PTV W +G+P+ A Sbjct: 966 LQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPV-GAELGLQ 1024 Query: 386 REVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQL--IRVI 443 + G ++ Q + Y C N G +SVL VPP ++ + L I Sbjct: 1025 LQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVL-VPPELIGDLDPLTNITAA 1083 Query: 444 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 503 L++ L C G P P +RWF+ + + Y + L++ +++D G+Y+C+A Sbjct: 1084 LHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLA 1143 Query: 504 TNILGKAENQVRLEVKDPTRIYRMPEDQVAR--RGTTVQLECRVKHDPSLKLTVSWLKDD 561 +N G+A +EV P I ++V + G T L C V P KLT W KD Sbjct: 1144 SNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLT--WFKDG 1201 Query: 562 EPLYIGNRMKKEDDS--LTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 610 PL G+ D L + G Y+C+A+ + + L+VL Sbjct: 1202 RPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVL 1252 Score = 149 bits (376), Expect = 7e-36 Identities = 152/581 (26%), Positives = 225/581 (38%), Gaps = 38/581 (6%) Query: 34 QNELTQPPTITKQSAKDHI-VDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSM 92 Q + +PP I + + P + + C+A+G P P+ W ++ + R+ Sbjct: 2205 QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALT-----RLEN 2259 Query: 93 RRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA-LSNRIRLQVSKSPLWPKENLDPVV 151 R+ T V+ R G Y C A + G S R+R+Q + + P+ V Sbjct: 2260 NSRA-TRVLRVRDAGL-------YTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVG 2311 Query: 152 VQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDY 211 + G L L+C+ P+P I W + + +D G + DY Sbjct: 2312 LAPGQ-LVLECSVEAE-PAPKITWHRDGIV-LQEDAHTQFPERGRFLQLQALSTADSGDY 2368 Query: 212 SCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIAS 271 SC AR T F +++ T + P+ V LL C A Sbjct: 2369 SCTARNAAGST---SVAFRVEIHTVPTIRSGPPAVN----------VSVNQTALLPCQAD 2415 Query: 272 GVPTPDIAWYKKGGDLPSDKAKFENFNK-ALRITNVSEEDSGEYFCLASNKMGSIRHTIS 330 GVP P ++W K L +FE + +LRI V +D+G Y CLASN GS R Sbjct: 2416 GVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRD 2475 Query: 331 VRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQ-SAPPNPNREVA 389 +RV P P NL L L C A+G+PKP V W +G+ L R + Sbjct: 2476 LRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLP 2535 Query: 390 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR 449 + ++ A ++C SNE G + + VPP + + V + Sbjct: 2536 SNALLLTAPGPQDSAQFECVVSNEVGE-AHRLYQVTVHVPPTIADDQTD-FTVTMMAPVV 2593 Query: 450 LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGK 509 L C G P PT+ W K G G Y V +G+LEI G YTC A N G Sbjct: 2594 LTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGV 2653 Query: 510 AENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIG-N 568 A V L V+ + +P A V L C P + T++W K+ + G + Sbjct: 2654 AHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIP--RPTITWQKEGLNVATGVS 2711 Query: 569 RMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609 L I + D G+Y C+A + K L V Sbjct: 2712 TQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVV 2752 Score = 144 bits (364), Expect = 2e-34 Identities = 146/562 (25%), Positives = 225/562 (40%), Gaps = 45/562 (8%) Query: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120 + CE +G P P W ++ + + + G L+ G EG Y C Sbjct: 900 LSCECRGVPFPKISWRKDGQPLP-GEGAGLQHVSAVGRLLY---LGQAQLAQEGTYTCEC 955 Query: 121 RNKFGTALSNRIRLQVSKSP--LWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSS 178 N G + S ++L+V P P+E V V + TL+CN G P P + W Sbjct: 956 SNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNAT-GKPPPTVTWERD 1013 Query: 179 SMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRG 238 +P+ + + + G YSC A + ++K F L VL Sbjct: 1014 G-QPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAE-NLAGRAERK--FELSVLVP-- 1067 Query: 239 VAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDL-PSDKAKFENF 297 P + ++ L L C A G+P P I W++ + P + Sbjct: 1068 -----PELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAG 1122 Query: 298 NKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA--PGEDGR 355 L++T E+DSG Y CLASN+ G R SV V P +E ++ G+ Sbjct: 1123 GWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAH 1182 Query: 356 LVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQ--ISSRAVYQCNTSNE 413 L+C G+P+P + W +G PL + ++ D ++ + Q +SS Y C +N Sbjct: 1183 LMCNVTGHPQPKLTWFKDGRPLARGDAH---HISPDGVLLQVLQANLSSAGHYSCIAANA 1239 Query: 414 HGYLLANAFVSVLDVPPRMLSPRNQL---IRVILYNRTRLDCPFFGSPIPTLRWFKNGQG 470 G + +SVL P + + + V + N L C P P + W K+G Sbjct: 1240 VGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAP 1299 Query: 471 SNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPED 530 + L+I +KED G YTCV TN LG+A +EV P I + +D Sbjct: 1300 FEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISK--DD 1357 Query: 531 QVARRG---------TTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK--KEDDSLTI 579 +A G +T+ LEC P T+ W KD +P+ +R++ E L I Sbjct: 1358 PLAEVGVKEVKTKVNSTLTLECESWAVP--PPTIRWYKDGQPVTPSSRLQVLGEGRLLQI 1415 Query: 580 FGVAERDQGSYTCVASTELDQD 601 D G Y CVA+ +D Sbjct: 1416 QPTQVSDSGRYLCVATNVAGED 1437 Score = 140 bits (354), Expect = 3e-33 Identities = 156/628 (24%), Positives = 253/628 (40%), Gaps = 86/628 (13%) Query: 33 IQNELTQPPTIT-KQSAKDHIVDPRDNIL-IECEAKGNPAPSFHWTRNSRFFNIAKDPRV 90 +Q E+ PP I + + +D + +EC A G P P+ W R+ + + + + Sbjct: 966 LQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQ--PVGAELGL 1023 Query: 91 SMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKE---NL 147 ++ + +L ++ + G Y C A N L+ R + S L P E +L Sbjct: 1024 QLQNQGQSLHVERAQAA----HTGRYSCVAEN-----LAGRAERKFELSVLVPPELIGDL 1074 Query: 148 DPVVVQEGA---PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVML 204 DP+ A PLTL C G+P P I W EP VS G + L ML Sbjct: 1075 DPLTNITAALHSPLTLLCEAM-GIPPPAIRWFRGE-EP------VSPGEDTYLLAGGWML 1126 Query: 205 QDMQTD------YSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMV 258 + QT YSC A + + F+++VL P + + V Sbjct: 1127 KMTQTQEQDSGLYSCLAS---NEAGEARRNFSVEVLV--------PPSIENEDLEEVIKV 1175 Query: 259 LRGMDLLLECIASGVPTPDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCL 317 L G L C +G P P + W+K G L D L++ + +G Y C+ Sbjct: 1176 LDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCI 1235 Query: 318 ASNKMGSIRHTISVRVKAAPYWL-----DEPKNLILAPGEDGRLVCRANGNPKPTVQWMV 372 A+N +G + V AP L + + + L+C A P P + WM Sbjct: 1236 AANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMK 1295 Query: 373 NGEPLQSAPPNPNREVAGDT--IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPP 430 +G P +++ N ++ T + + Q Y C +NE G + N V VL +PP Sbjct: 1296 DGAPFEASR---NIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL-IPP 1351 Query: 431 RMLS--PRNQL----IRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENG 484 + P ++ ++ + + L+C + P PT+RW+K+GQ + E Sbjct: 1352 SISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGR 1411 Query: 485 SLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYR----------MPEDQVAR 534 L+I+ + D G Y CVATN+ G+ + + ++ P + + ++ AR Sbjct: 1412 LLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEAR 1471 Query: 535 RGTT----------VQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK--KEDDSLTIFGV 582 G T L C P LT W ++D+PL G+ + + L I V Sbjct: 1472 GGVTEYREIVENNPAYLYCDTNAIPPPDLT--WYREDQPLSAGDEVSVLQGGRVLQIPLV 1529 Query: 583 AERDQGSYTCVASTELDQDLAKAYLTVL 610 + G Y+C AS E+ +D L VL Sbjct: 1530 RAENAGRYSCKASNEVGEDWLHYELLVL 1557 Score = 137 bits (345), Expect = 3e-32 Identities = 156/620 (25%), Positives = 248/620 (40%), Gaps = 63/620 (10%) Query: 24 AIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFN 83 ++E+ + PSI+NE + H++ C G+P P W ++ R Sbjct: 1155 SVEVLVPPSIENEDLEEVIKVLDGQTAHLM---------CNVTGHPQPKLTWFKDGRPLA 1205 Query: 84 IAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPL-- 141 +S G L+ ++ G Y C A N G + +L V +P Sbjct: 1206 RGDAHHISP---DGVLLQVLQAN---LSSAGHYSCIAANAVGEK-TKHFQLSVLLAPTIL 1258 Query: 142 -WPKENLDP-VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSME-PITQDKRVSQGHNGDLY 198 +++ D V V P++L C PSP I WM +++ ++ G +G L Sbjct: 1259 GGAEDSADEEVTVTVNNPISLICEAL-AFPSPNITWMKDGAPFEASRNIQLLPGTHG-LQ 1316 Query: 199 FSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMV 258 N +D Y+C ++ + ++VL +++ P +++ Sbjct: 1317 ILNAQKEDAG-QYTCVVTNELGEAVKN---YHVEVLIPPSISKDDPLAEVGVKEVKTKV- 1371 Query: 259 LRGMDLLLECIASGVPTPDIAWYKKGGDL-PSDKAKFENFNKALRITNVSEEDSGEYFCL 317 L LEC + VP P I WYK G + PS + + + L+I DSG Y C+ Sbjct: 1372 --NSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCV 1429 Query: 318 ASNKMGSIRHTISVRVKAAPYWLD----EPKNLILAPGEDGR----------------LV 357 A+N G +V ++ P + IL+ E+ R L Sbjct: 1430 ATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLY 1489 Query: 358 CRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYL 417 C N P P + W +PL SA + G + + + Y C SNE G Sbjct: 1490 CDTNAIPPPDLTWYREDQPL-SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGED 1548 Query: 418 LANAFVSVLDVPPRMLSPRNQLIRVILYNRTR---LDCPFFGSPIPTLRWFKNGQGSNLD 474 + + VL PP +L +L+ + N + L CP G+P+PT+ W +NG + Sbjct: 1549 WLHYELLVL-TPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFS-P 1606 Query: 475 GGNYHVYENGS-LEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQV- 532 V E+G L++ D Y CVA N G AE L V+ P RI + +QV Sbjct: 1607 SPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVT 1666 Query: 533 ARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTI-FGVAE-RDQGSY 590 A ++V L C V P+ ++T W KD + L +G + + T+ G A D G Y Sbjct: 1667 AILNSSVSLPCDVHAHPNPEVT--WYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMY 1724 Query: 591 TCVASTELDQDLAKAYLTVL 610 TC A +D L+VL Sbjct: 1725 TCEALNAAGRDQKLVQLSVL 1744 Score = 137 bits (344), Expect = 4e-32 Identities = 126/505 (24%), Positives = 206/505 (40%), Gaps = 31/505 (6%) Query: 30 DPSIQNELTQPPTITKQSAKDHIVDPR-DNILIECEAKGNPAPSFHWTRNSRFFNIAKDP 88 +P + PP+I + K ++ ++ +EC+A G P P W ++++ + Sbjct: 6 EPLLNTGSVVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGW 65 Query: 89 R-----VSMRRRSGTLVIDF-RSGGRPEEYEGE---YQCFARNKFGTALSNRIRLQVSKS 139 + + G ++D +S P EG+ Y C A N+ GTA + L ++ Sbjct: 66 AGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPP 125 Query: 140 PLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYF 199 + V+ GA + LQC G+P+P + W + + +G + Sbjct: 126 SVLGAGAAQEVLGLAGADVELQCWTS-GVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLR 184 Query: 200 SNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVL 259 + Y C A F+ QQ F L+V P ++ V+ Sbjct: 185 ITGSHVGDEGRYQCVA---FSPAGQQARDFQLRV--------HAPPTIWGSNETGEVAVM 233 Query: 260 RGMDLLLECIASGVPTPDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCLA 318 + L C A GVPTP+I W+K G LP S K + + L++ D+G Y C A Sbjct: 234 EDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKA 293 Query: 319 SNKMGSIRHTISVRVKAAPYWLD---EPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGE 375 SN +G+ + V P P + G L C A G+P PT+ W G Sbjct: 294 SNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGL 353 Query: 376 PLQSAPPNPNR-EVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLS 434 P+ A N +R E G + +S +Y C S+ G + V V VPP++L Sbjct: 354 PV--AESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEV-QVPPQLLV 410 Query: 435 PRNQ-LIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRK 493 + I+ L C GSP+PT++W +NG+ + G + +L I + Sbjct: 411 AEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVEL 470 Query: 494 EDQGIYTCVATNILGKAENQVRLEV 518 + G++ C ATN G A +V + V Sbjct: 471 DHSGLFACQATNEAGTAGAEVEVSV 495 Score = 133 bits (334), Expect = 6e-31 Identities = 153/607 (25%), Positives = 231/607 (38%), Gaps = 88/607 (14%) Query: 25 IEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNI 84 +++P + L Q TI Q + + C+A G+P P+ W +N R Sbjct: 402 VQVPPQLLVAEGLGQVTTIVGQPLE-----------LPCQASGSPVPTIQWLQNGR--PA 448 Query: 85 AKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPK 144 + V + + TL ID ++ G + C A N+ GTA + ++VS W Sbjct: 449 EELAGVQVASQGTTLHIDHVE----LDHSGLFACQATNEAGTAGAE---VEVSVHGEWAP 501 Query: 145 ENLDPVVVQ------EGAPLTLQCNPP--------------PGLPSPVIFWMSSSMEPIT 184 L+ + Q + C+PP G SP W + P Sbjct: 502 GVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIP-- 559 Query: 185 QDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTP 244 V+ L V L+D + Y+C A + K LKVL + Sbjct: 560 ----VAYSLPPPLQIEKVDLRD-EGIYTCAAT---NLAGESKREVALKVLVPPNI----- 606 Query: 245 SFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFN-KALRI 303 + ++ VL + LEC+ASGVP PD++W+K + S + + + LRI Sbjct: 607 -----EPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRI 661 Query: 304 TNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDG--------R 355 D+G Y C+ASN GS +RV P + L P G R Sbjct: 662 EQAQLSDAGSYRCVASNVAGSTELRYGLRVNV-------PPRITLPPSLPGPVLVNTPVR 714 Query: 356 LVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV--AGDTIIFRDTQISSRAVYQCNTSNE 413 L C A G P PT+ W+ +G P+ A P +V G + + S Y C + Sbjct: 715 LTCNATGAPSPTLMWLKDGNPVSPA-GTPGLQVFPGGRVLTLASARASDSGRYSCVAVSA 773 Query: 414 HGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL 473 G + + V +PP +L + V+ L+C P P L W+K+G+ Sbjct: 774 VGEDRQDVVLQV-HMPPSILGEELN-VSVVANESVALECQSHAMPPPVLSWWKDGRPLEP 831 Query: 474 DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEV-KDPTRIYRMPEDQV 532 G + + L++ D G YTC A N G +E L V P R Sbjct: 832 RPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLT 891 Query: 533 ARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL---YIGNRMKKEDDSLTIFGVAE-RDQG 588 R G +L C + P K +SW KD +PL G + L G A+ +G Sbjct: 892 VREGHPTRLSCECRGVPFPK--ISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEG 949 Query: 589 SYTCVAS 595 +YTC S Sbjct: 950 TYTCECS 956 Score = 122 bits (306), Expect = 1e-27 Identities = 103/378 (27%), Positives = 159/378 (42%), Gaps = 29/378 (7%) Query: 244 PSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK-------------GGDLPSD 290 P + G ++ + G L LEC A+G P P+I W K G DL Sbjct: 16 PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 75 Query: 291 KA---KFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDE--PKN 345 + + + ++L + E DSG Y C A N+ G+ + + V P L + Sbjct: 76 QVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQE 135 Query: 346 LILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAV 405 ++ G D L C +G P P V+W + +P+ P+ + G + + + Sbjct: 136 VLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGR 195 Query: 406 YQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWF 465 YQC + G + + V P S + V+ + +L C G P P + WF Sbjct: 196 YQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWF 255 Query: 466 KNGQGSNLDGGNYHVYENGSLEIKMIRKE--DQGIYTCVATNILGKAENQVRLEVKDPTR 523 K+G + L VY G ++++ R + D G+YTC A+N +G AE RL+V P Sbjct: 256 KDG--ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPT 313 Query: 524 IY---RMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDS--LT 578 I P A G V LEC + PS T+SW + P+ N + E D L Sbjct: 314 IEGAGGRPYVVKAVAGRPVALECVARGHPS--PTLSWHHEGLPVAESNESRLETDGSVLR 371 Query: 579 IFGVAERDQGSYTCVAST 596 + E G Y+CVAS+ Sbjct: 372 LESPGEASSGLYSCVASS 389 Score = 119 bits (298), Expect = 8e-27 Identities = 102/396 (25%), Positives = 173/396 (43%), Gaps = 32/396 (8%) Query: 37 LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96 + Q P + + D + + C+A+G+P P+ W ++ + + A+ + S Sbjct: 2751 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTI--QPS 2808 Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 156 G L++ G + G Y C A N G A R+ L + P++ D + + G Sbjct: 2809 GELLVKNLEG----QDAGTYTCTAENAVGRA-RRRVHLTILVLPVFTTLPGDRSL-RLGD 2862 Query: 157 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA- 215 L L+C G P+P I W + P+T+ VS+ G + ++ Y C A Sbjct: 2863 RLWLRC-AARGSPTPRIGWTVND-RPVTEG--VSEQDGGSTLQRAAVSREDSGTYVCWAE 2918 Query: 216 -RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLR-GMDLLLECIASGV 273 R T + + VL QG A S +V G + L+C+ G Sbjct: 2919 NRVGRTQAVSFVHVKEAPVL---------------QGEAFSYLVEPVGGSIQLDCVVRGD 2963 Query: 274 PTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRV 333 P PDI W K G L + + N +L I +D+G Y CLA N+MG + + + + Sbjct: 2964 PVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVL 3023 Query: 334 KAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTI 393 ++AP + EP+++ + G+D L C+A G P PT++W+ G+PL+++ R + ++ Sbjct: 3024 QSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRAS--RRLRTLPDGSL 3081 Query: 394 IFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVP 429 + + Y C N G A AF+ V P Sbjct: 3082 WLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 3117 Score = 112 bits (280), Expect = 1e-24 Identities = 126/483 (26%), Positives = 198/483 (40%), Gaps = 44/483 (9%) Query: 155 GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNV----MLQDMQTD 210 G LTL+C+ G P P I W+ + + G+ DL + V +L + Q+ Sbjct: 33 GQSLTLECDAN-GFPVPEIVWLKDAQ--LVGVPLGWAGYGWDLGWGQVGGHRLLDEGQS- 88 Query: 211 YSCNARFHFTHTIQQKNP--FTLKVLTTRGVAER-------TPSFMYPQGTASSQMVLRG 261 HF IQ+ + ++ + G A+R TP + G A + L G Sbjct: 89 ------LHFPR-IQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAG 141 Query: 262 MDLLLECIASGVPTPDIAWYK-KGGDLPSDK-AKFENFNKALRITNVSEEDSGEYFCLAS 319 D+ L+C SGVPTP + W K + LP + + + LRIT D G Y C+A Sbjct: 142 ADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAF 201 Query: 320 NKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDG--RLVCRANGNPKPTVQWMVNGEPL 377 + G +RV A P + +A ED +L+C A G P P + W +G L Sbjct: 202 SPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALL 261 Query: 378 QSAPPNPNREV---AGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRM-- 432 P + V G + Q S VY C SN G + V VPP + Sbjct: 262 ----PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY-VPPTIEG 316 Query: 433 LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIR 492 R +++ + L+C G P PTL W G + + L ++ Sbjct: 317 AGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPG 376 Query: 493 KEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE-DQVAR-RGTTVQLECRVKHDPS 550 + G+Y+CVA++ G+A Q +EV+ P ++ QV G ++L C+ P Sbjct: 377 EASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSP- 435 Query: 551 LKLTVSWLKDDEPL--YIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLT 608 T+ WL++ P G ++ + +L I V G + C A+ E A+ ++ Sbjct: 436 -VPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVS 494 Query: 609 VLG 611 V G Sbjct: 495 VHG 497 >gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] Length = 3874 Score = 181 bits (460), Expect = 1e-45 Identities = 165/587 (28%), Positives = 245/587 (41%), Gaps = 47/587 (8%) Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTR-NSRFFNIAKDPRVSMRRRSGT 98 PPTI D V +++ C + G PAP+ W++ ++ RVS SG Sbjct: 2665 PPTIADDQT-DFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSP---SGA 2720 Query: 99 LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLW-PKENLDPVVVQEGAP 157 L I G + G Y C ARN G A + L V SP+ P ++ V +E Sbjct: 2721 LEI----GQALPIHAGRYTCSARNSAGVA-HKHVFLTVQASPVVKPLPSVVRAVAEEEVL 2775 Query: 158 LTLQCNPPPGLPSPVIFWMSSSMEPITQ-DKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 216 L + + G+P P I W + T +V G G L ++ +D +Y C A Sbjct: 2776 LPCEAS---GIPRPTITWQKEGLNVATGVSTQVLPG--GQLRIAHASPEDAG-NYLCIA- 2828 Query: 217 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 276 KN + TR V + P + G L C A G P P Sbjct: 2829 ---------KNSAGSAMGKTRLVVQVPPVI---ENGLPDLSTTEGSHAFLPCKARGSPEP 2876 Query: 277 DIAWYKKGGDLPSDKAKFE-NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 335 +I W K G + + KF + L + N+ +D+G Y C A N +G R + + + Sbjct: 2877 NITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILV 2936 Query: 336 APYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIF 395 P + P + L G+ L C A G+P P + W VN P+ + + G T+ Sbjct: 2937 LPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV---SEQDGGSTLQR 2993 Query: 396 RDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFF 455 Y C N G A +FV V + P + L+ + +LDC Sbjct: 2994 AAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPV-GGSIQLDCVVR 3052 Query: 456 GSPIPTLRWFKNG---QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAEN 512 G P+P + W K+G +GS+L H +NGSL I ++D G Y C+A N +G A+ Sbjct: 3053 GDPVPDIHWIKDGLPLRGSHLR----HQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKK 3108 Query: 513 QVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKK 572 V L ++ P+D R G V L C+ +P+ T+ WL+ +PL R++ Sbjct: 3109 VVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPT--PTIEWLQAGQPLRASRRLRT 3166 Query: 573 -EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGNCPCSPW 618 D SL + V D G+Y CVA L A+A+L V G P W Sbjct: 3167 LPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGE-PQGSW 3212 Score = 156 bits (395), Expect = 5e-38 Identities = 153/604 (25%), Positives = 252/604 (41%), Gaps = 55/604 (9%) Query: 41 PTI---TKQSAKDHIVDPRDN-ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96 PTI + SA + + +N I + CEA P+P+ W ++ F +++ ++ + Sbjct: 1346 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL-LPGTH 1404 Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNR-----IRLQVSKSPLWPKENLDPVV 151 G +++ + +E G+Y C N+ G A+ N I +SK + + V Sbjct: 1405 GLQILNAQ-----KEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVK 1459 Query: 152 VQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDY 211 + + LTL+C +P P I W +P+T R+ G L LQ T Sbjct: 1460 TKVNSTLTLECESW-AVPPPTIRWYKDG-QPVTPSSRLQVLGEGRL------LQIQPTQV 1511 Query: 212 SCNARFHFTHT------------IQQKNPFTLKVLTTRGVAERTPSFMYPQGTASS-QMV 258 S + R+ T + Q P KV E +G + + + Sbjct: 1512 SDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREI 1571 Query: 259 LRGMDLLLECIASGVPTPDIAWYKKGGDLPS-DKAKFENFNKALRITNVSEEDSGEYFCL 317 + L C + +P PD+ WY++ L + D+ + L+I V E++G Y C Sbjct: 1572 VENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCK 1631 Query: 318 ASNKMGSIRHTISVRVKAAPYWLDEPKNLI----LAPGEDGRLVCRANGNPKPTVQWMVN 373 ASN++G + V P L + + L+ + L C A GNP PT+ W+ N Sbjct: 1632 ASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQN 1691 Query: 374 GEPLQSAPPNPNREVAGDTIIFR--DTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPR 431 G P P+P +V D + + +++ A Y C N+ G F + VPPR Sbjct: 1692 GLPFS---PSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSA-EKLFTLRVQVPPR 1747 Query: 432 MLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMI 491 + + + IL + L C P P + W+K+ Q +L + + +L++ Sbjct: 1748 IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRA 1807 Query: 492 RKEDQGIYTCVATNILGKAENQVRLEVKDP---TRIYRMPEDQV-ARRGTTVQLECRVKH 547 R D G+YTC A N G+ + V+L V P + R P+D V R G L C Sbjct: 1808 RLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCET-- 1865 Query: 548 DPSLKLTVSWLKDDEPLYIGNRMK--KEDDSLTIFGVAERDQGSYTCVASTELDQDLAKA 605 D + TV+W KD +PL + R + + L I D+G Y+C S + + Sbjct: 1866 DALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTF 1925 Query: 606 YLTV 609 LTV Sbjct: 1926 TLTV 1929 Score = 156 bits (394), Expect = 6e-38 Identities = 152/563 (26%), Positives = 234/563 (41%), Gaps = 70/563 (12%) Query: 57 DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYE--- 113 D ++ CE P P+ W ++ + P V +R R G R E E Sbjct: 1857 DKAVLSCETDALPEPTVTWYKDGQ-------PLVLAQRTQA-----LRGGQRLEIQEAQV 1904 Query: 114 ---GEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPS 170 G Y C N G A+ L V P + + V G+PL L C+ G+P+ Sbjct: 1905 SDKGLYSCKVSNVAGEAVRT-FTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVS-GVPA 1962 Query: 171 PVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFT 230 P + W+ M + G L S + T Y+C A + + F Sbjct: 1963 PTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGT-YTCVAE---NTQAEARKDFV 2018 Query: 231 LKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSD 290 + VL VA R S G A VL G ++ L+C A G P PD+AW K G L D Sbjct: 2019 VAVL----VAPRIRS----SGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQD 2070 Query: 291 KAKFENF---NKALRITNVSEEDSGEYFCLASNKMG--SIRHTISVRV-KAAPYWLDEPK 344 F +L + + D+G Y C+A N G + HT++V V D Sbjct: 2071 MGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSG 2130 Query: 345 NLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV---AGDTIIFRDTQIS 401 L+ PGE +VC G+P V W+ +G PL P R + +G T+ Q++ Sbjct: 2131 TLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL----PLSQRTLLHGSGHTLRISKVQLA 2186 Query: 402 SRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSP---RNQLIRVILYNRTRLDCPFFGSP 458 ++ C ++ G N F + VPP +L P +N ++ V+ + L C G P Sbjct: 2187 DAGIFTCVAASPAGVADRN-FTLQVQVPP-VLEPVEFQNDVV-VVRGSLVELPCEARGVP 2243 Query: 459 IPTLRWFKNGQ---GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVR 515 +P + W K+G+ +L+ G SL+++ + D G Y+CVA + G+A + Sbjct: 2244 LPLVSWMKDGEPLLSQSLEQG-------PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQ 2296 Query: 516 LEVKDPTRI--YRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKE 573 L V +P I P + G ++L C + P +T W KD + L + E Sbjct: 2297 LTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNIT--WHKDGQAL-----TRLE 2349 Query: 574 DDSLTIFGVAERDQGSYTCVAST 596 ++S + RD G YTC+A + Sbjct: 2350 NNSRATRVLRVRDAGLYTCLAES 2372 Score = 151 bits (382), Expect = 2e-36 Identities = 149/571 (26%), Positives = 230/571 (40%), Gaps = 37/571 (6%) Query: 40 PPTI---TKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96 PP I T++ ++ V+ + ++C A GNP P+ W +N F+ PR+ + Sbjct: 1650 PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFS--PSPRLQVLEDG 1707 Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 156 L + Y C A N+ G+A L+V P +L+ V + Sbjct: 1708 QVLQVSTAEVADA----ASYMCVAENQAGSA-EKLFTLRVQVPPRIAGLDLEQVTAILNS 1762 Query: 157 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 216 ++L C+ P+P + W S ++ L L D Y+C A Sbjct: 1763 SVSLPCDVHAH-PNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGM-YTCEA- 1819 Query: 217 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMY-PQGTASSQMVLRGMDLLLECIASGVPT 275 + + L VL P+F P+G + +V G +L C +P Sbjct: 1820 --LNAAGRDQKLVQLSVLVP-------PAFRQAPRGPQDAVLVRVGDKAVLSCETDALPE 1870 Query: 276 PDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVK 334 P + WYK G L + + + + L I D G Y C SN G T ++ V+ Sbjct: 1871 PTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQ 1930 Query: 335 AAPYWLDEPKNLILA--PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT 392 P + + PK ++ G L C +G P PTV W+ + P++S+ + G Sbjct: 1931 VPPTF-ENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRL 1989 Query: 393 IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDC 452 + R Q + Y C N + V+VL P S + V+ RLDC Sbjct: 1990 QLSR-LQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC 2048 Query: 453 PFFGSPIPTLRWFKNGQGSNLDGGNY--HVYENGSLEIKMIRKEDQGIYTCVATNILGKA 510 G P P + W K+G D G + + GSL +K +R D G YTCVA N G+ Sbjct: 2049 EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED 2108 Query: 511 ENQVRLEVKDPTRIYRMPEDQ---VARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIG 567 + V P I + + V+R G V + C V+ P + VSWLKD PL + Sbjct: 2109 ARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIH--VSWLKDGLPLPLS 2166 Query: 568 NR--MKKEDDSLTIFGVAERDQGSYTCVAST 596 R + +L I V D G +TCVA++ Sbjct: 2167 QRTLLHGSGHTLRISKVQLADAGIFTCVAAS 2197 Score = 150 bits (380), Expect = 3e-36 Identities = 144/580 (24%), Positives = 228/580 (39%), Gaps = 37/580 (6%) Query: 37 LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96 L P + A++H V + ++CEA G P P W ++ P + Sbjct: 2022 LVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDG 2081 Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFG-TALSNRIRLQVSKSPLWPKENLDPVVVQEG 155 G+LV+ G G Y C A N G A + + + V + + +V + G Sbjct: 2082 GSLVLK----GLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPG 2137 Query: 156 APLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA 215 +T+ C P G P + W+ + + + G L S V L D ++C A Sbjct: 2138 ELVTMVC-PVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGI-FTCVA 2195 Query: 216 RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 275 + +N FTL+V + P + P + +V+RG + L C A GVP Sbjct: 2196 A--SPAGVADRN-FTLQV--------QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPL 2244 Query: 276 PDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 335 P ++W K G L S + +L++ V DSG Y C+A ++ G R + V Sbjct: 2245 PLVSWMKDGEPLLSQSLE---QGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVME 2301 Query: 336 APYWLD--EPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTI 393 P+ D +P L L PG L+C A G P+P + W +G+ L N Sbjct: 2302 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRAT------ 2355 Query: 394 IFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRN-QLIRVILYNRTRLDC 452 R ++ +Y C + G + +F + PP ++ PR + + + + L+C Sbjct: 2356 --RVLRVRDAGLYTCLAESPAG-AIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLEC 2412 Query: 453 PFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAEN 512 P P + W ++G D L+++ + D G Y+C A N G Sbjct: 2413 SVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSV 2472 Query: 513 QVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKK 572 R+E+ I P T L C+ P+ VSW KD PL + + Sbjct: 2473 AFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPA--PLVSWRKDRVPLDPRSPRFE 2530 Query: 573 --EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 610 + SL I V +D G Y C+AS D L VL Sbjct: 2531 ILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVL 2570 Score = 149 bits (376), Expect = 7e-36 Identities = 146/591 (24%), Positives = 236/591 (39%), Gaps = 52/591 (8%) Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 99 PP IT + V + + C A G P+P+ W ++ + A P + + L Sbjct: 785 PPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVL 844 Query: 100 VIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLD-PVVVQEGAPL 158 + + R + G Y C A + G + + LQV P E L+ VV E L Sbjct: 845 TL---ASARASD-SGRYSCVAVSAVGEDRQDVV-LQVHMPPSILGEELNVSVVANESVAL 899 Query: 159 TLQCNPPPGLPSPVIFWMSSS--MEP-----ITQDKRVSQGHNGDLYFSNVMLQDMQTDY 211 Q + +P PV+ W +EP ++ DK + Q D++ + Y Sbjct: 900 ECQSH---AMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAG--------HY 948 Query: 212 SCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIAS 271 +C A + + + L V ++P + + V G L C Sbjct: 949 TCEA---LNQAGRSEKHYNLNVWVAP---------VFPLRESHTLTVREGHPTSLSCECR 996 Query: 272 GVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEED---SGEYFCLASNKMGSIRHT 328 GVP P I+W K G LP + A ++ + R+ + + G Y C SN +G+ Sbjct: 997 GVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQD 1056 Query: 329 ISVRVKAAPYWL---DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPN 385 + + V P + P + + L C A G P PTV W +G+P+ A Sbjct: 1057 LQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPV-GAELGLQ 1115 Query: 386 REVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQL--IRVI 443 + G ++ Q + Y C N G +SVL VPP ++ + L I Sbjct: 1116 LQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVL-VPPELIGDLDPLTNITAA 1174 Query: 444 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 503 L++ L C G P P +RWF+ + + Y + L++ +++D G+Y+C+A Sbjct: 1175 LHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLA 1234 Query: 504 TNILGKAENQVRLEVKDPTRIYRMPEDQVAR--RGTTVQLECRVKHDPSLKLTVSWLKDD 561 +N G+A +EV P I ++V + G T L C V P KLT W KD Sbjct: 1235 SNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLT--WFKDG 1292 Query: 562 EPLYIGNRMKKEDDS--LTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 610 PL G+ D L + G Y+C+A+ + + L+VL Sbjct: 1293 RPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVL 1343 Score = 149 bits (376), Expect = 7e-36 Identities = 152/581 (26%), Positives = 225/581 (38%), Gaps = 38/581 (6%) Query: 34 QNELTQPPTITKQSAKDHI-VDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSM 92 Q + +PP I + + P + + C+A+G P P+ W ++ + R+ Sbjct: 2296 QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALT-----RLEN 2350 Query: 93 RRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA-LSNRIRLQVSKSPLWPKENLDPVV 151 R+ T V+ R G Y C A + G S R+R+Q + + P+ V Sbjct: 2351 NSRA-TRVLRVRDAGL-------YTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVG 2402 Query: 152 VQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDY 211 + G L L+C+ P+P I W + + +D G + DY Sbjct: 2403 LAPGQ-LVLECSVEAE-PAPKITWHRDGIV-LQEDAHTQFPERGRFLQLQALSTADSGDY 2459 Query: 212 SCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIAS 271 SC AR T F +++ T + P+ V LL C A Sbjct: 2460 SCTARNAAGST---SVAFRVEIHTVPTIRSGPPAVN----------VSVNQTALLPCQAD 2506 Query: 272 GVPTPDIAWYKKGGDLPSDKAKFENFNK-ALRITNVSEEDSGEYFCLASNKMGSIRHTIS 330 GVP P ++W K L +FE + +LRI V +D+G Y CLASN GS R Sbjct: 2507 GVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRD 2566 Query: 331 VRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQ-SAPPNPNREVA 389 +RV P P NL L L C A+G+PKP V W +G+ L R + Sbjct: 2567 LRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLP 2626 Query: 390 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR 449 + ++ A ++C SNE G + + VPP + + V + Sbjct: 2627 SNALLLTAPGPQDSAQFECVVSNEVGE-AHRLYQVTVHVPPTIADDQTD-FTVTMMAPVV 2684 Query: 450 LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGK 509 L C G P PT+ W K G G Y V +G+LEI G YTC A N G Sbjct: 2685 LTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGV 2744 Query: 510 AENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIG-N 568 A V L V+ + +P A V L C P + T++W K+ + G + Sbjct: 2745 AHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIP--RPTITWQKEGLNVATGVS 2802 Query: 569 RMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609 L I + D G+Y C+A + K L V Sbjct: 2803 TQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVV 2843 Score = 143 bits (360), Expect = 5e-34 Identities = 145/562 (25%), Positives = 224/562 (39%), Gaps = 45/562 (8%) Query: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120 + CE +G P P W ++ + + + G L+ G EG Y C Sbjct: 991 LSCECRGVPFPKISWRKDGQPLP-GEGAGLQHVSAVGRLLY---LGQAQLAQEGTYTCEC 1046 Query: 121 RNKFGTALSNRIRLQVSKSP--LWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSS 178 N G + S ++L+V P P+E V V + TL+CN G P P + W Sbjct: 1047 SNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNAT-GKPPPTVTWERD 1104 Query: 179 SMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRG 238 +P+ + + + G YSC A + ++K F L VL Sbjct: 1105 G-QPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAE-NLAGRAERK--FELSVLVP-- 1158 Query: 239 VAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDL-PSDKAKFENF 297 P + ++ L L C A G+P P I W++ + P + Sbjct: 1159 -----PELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAG 1213 Query: 298 NKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA--PGEDGR 355 L++T E+DSG Y CLASN+ G R SV V P +E ++ G+ Sbjct: 1214 GWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAH 1273 Query: 356 LVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQ--ISSRAVYQCNTSNE 413 L+C G+P+P + W +G PL + ++ D ++ + Q +SS Y C +N Sbjct: 1274 LMCNVTGHPQPKLTWFKDGRPLARGDAH---HISPDGVLLQVLQANLSSAGHYSCIAANA 1330 Query: 414 HGYLLANAFVSVLDVPPRMLSPRNQL---IRVILYNRTRLDCPFFGSPIPTLRWFKNGQG 470 G + +SVL P + + + V + N L C P P + W K+G Sbjct: 1331 VGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAP 1390 Query: 471 SNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPED 530 + L+I +KED G YTCV TN LG+A +EV P I + +D Sbjct: 1391 FEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISK--DD 1448 Query: 531 QVARRG---------TTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK--KEDDSLTI 579 + G +T+ LEC P T+ W KD +P+ +R++ E L I Sbjct: 1449 PLGEVGVKEVKTKVNSTLTLECESWAVP--PPTIRWYKDGQPVTPSSRLQVLGEGRLLQI 1506 Query: 580 FGVAERDQGSYTCVASTELDQD 601 D G Y CVA+ +D Sbjct: 1507 QPTQVSDSGRYLCVATNVAGED 1528 Score = 141 bits (356), Expect = 2e-33 Identities = 156/628 (24%), Positives = 253/628 (40%), Gaps = 86/628 (13%) Query: 33 IQNELTQPPTIT-KQSAKDHIVDPRDNIL-IECEAKGNPAPSFHWTRNSRFFNIAKDPRV 90 +Q E+ PP I + + +D + +EC A G P P+ W R+ + + + + Sbjct: 1057 LQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQ--PVGAELGL 1114 Query: 91 SMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKE---NL 147 ++ + +L ++ + G Y C A N L+ R + S L P E +L Sbjct: 1115 QLQNQGQSLHVERAQAA----HTGRYSCVAEN-----LAGRAERKFELSVLVPPELIGDL 1165 Query: 148 DPVVVQEGA---PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVML 204 DP+ A PLTL C G+P P I W EP VS G + L ML Sbjct: 1166 DPLTNITAALHSPLTLLCEAM-GIPPPAIRWFRGE-EP------VSPGEDTYLLAGGWML 1217 Query: 205 QDMQTD------YSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMV 258 + QT YSC A + + F+++VL P + + V Sbjct: 1218 KMTQTQEQDSGLYSCLAS---NEAGEARRNFSVEVLV--------PPSIENEDLEEVIKV 1266 Query: 259 LRGMDLLLECIASGVPTPDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCL 317 L G L C +G P P + W+K G L D L++ + +G Y C+ Sbjct: 1267 LDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCI 1326 Query: 318 ASNKMGSIRHTISVRVKAAPYWL-----DEPKNLILAPGEDGRLVCRANGNPKPTVQWMV 372 A+N +G + V AP L + + + L+C A P P + WM Sbjct: 1327 AANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMK 1386 Query: 373 NGEPLQSAPPNPNREVAGDT--IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPP 430 +G P +++ N ++ T + + Q Y C +NE G + N V VL +PP Sbjct: 1387 DGAPFEASR---NIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL-IPP 1442 Query: 431 RMLS--PRNQL----IRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENG 484 + P ++ ++ + + L+C + P PT+RW+K+GQ + E Sbjct: 1443 SISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGR 1502 Query: 485 SLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYR----------MPEDQVAR 534 L+I+ + D G Y CVATN+ G+ + + ++ P + + ++ AR Sbjct: 1503 LLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEAR 1562 Query: 535 RGTT----------VQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK--KEDDSLTIFGV 582 G T L C P LT W ++D+PL G+ + + L I V Sbjct: 1563 GGVTEYREIVENNPAYLYCDTNAIPPPDLT--WYREDQPLSAGDEVSVLQGGRVLQIPLV 1620 Query: 583 AERDQGSYTCVASTELDQDLAKAYLTVL 610 + G Y+C AS E+ +D L VL Sbjct: 1621 RAENAGRYSCKASNEVGEDWLHYELLVL 1648 Score = 137 bits (344), Expect = 4e-32 Identities = 156/620 (25%), Positives = 248/620 (40%), Gaps = 63/620 (10%) Query: 24 AIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFN 83 ++E+ + PSI+NE + H++ C G+P P W ++ R Sbjct: 1246 SVEVLVPPSIENEDLEEVIKVLDGQTAHLM---------CNVTGHPQPKLTWFKDGRPLA 1296 Query: 84 IAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPL-- 141 +S G L+ ++ G Y C A N G + +L V +P Sbjct: 1297 RGDAHHISP---DGVLLQVLQAN---LSSAGHYSCIAANAVGEK-TKHFQLSVLLAPTIL 1349 Query: 142 -WPKENLDP-VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSME-PITQDKRVSQGHNGDLY 198 +++ D V V P++L C PSP I WM +++ ++ G +G L Sbjct: 1350 GGAEDSADEEVTVTVNNPISLICEAL-AFPSPNITWMKDGAPFEASRNIQLLPGTHG-LQ 1407 Query: 199 FSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMV 258 N +D Y+C ++ + ++VL +++ P +++ Sbjct: 1408 ILNAQKEDAG-QYTCVVTNELGEAVKN---YHVEVLIPPSISKDDPLGEVGVKEVKTKV- 1462 Query: 259 LRGMDLLLECIASGVPTPDIAWYKKGGDL-PSDKAKFENFNKALRITNVSEEDSGEYFCL 317 L LEC + VP P I WYK G + PS + + + L+I DSG Y C+ Sbjct: 1463 --NSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCV 1520 Query: 318 ASNKMGSIRHTISVRVKAAPYWLD----EPKNLILAPGEDGR----------------LV 357 A+N G +V ++ P + IL+ E+ R L Sbjct: 1521 ATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLY 1580 Query: 358 CRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYL 417 C N P P + W +PL SA + G + + + Y C SNE G Sbjct: 1581 CDTNAIPPPDLTWYREDQPL-SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGED 1639 Query: 418 LANAFVSVLDVPPRMLSPRNQLIRVILYNRTR---LDCPFFGSPIPTLRWFKNGQGSNLD 474 + + VL PP +L +L+ + N + L CP G+P+PT+ W +NG + Sbjct: 1640 WLHYELLVL-TPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFS-P 1697 Query: 475 GGNYHVYENGS-LEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQV- 532 V E+G L++ D Y CVA N G AE L V+ P RI + +QV Sbjct: 1698 SPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVT 1757 Query: 533 ARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTI-FGVAE-RDQGSY 590 A ++V L C V P+ ++T W KD + L +G + + T+ G A D G Y Sbjct: 1758 AILNSSVSLPCDVHAHPNPEVT--WYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMY 1815 Query: 591 TCVASTELDQDLAKAYLTVL 610 TC A +D L+VL Sbjct: 1816 TCEALNAAGRDQKLVQLSVL 1835 Score = 134 bits (336), Expect = 3e-31 Identities = 153/607 (25%), Positives = 231/607 (38%), Gaps = 88/607 (14%) Query: 25 IEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNI 84 +++P + L Q TI Q + + C+A G+P P+ W +N R Sbjct: 493 VQVPPQLLVAEGLGQVTTIVGQPLE-----------LPCQASGSPVPTIQWLQNGR--PA 539 Query: 85 AKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPK 144 + V + + TL ID ++ G + C A N+ GTA + ++VS W Sbjct: 540 EELAGVQVASQGTTLHIDHVE----LDHSGLFACQATNEAGTAGAE---VEVSVHGEWAP 592 Query: 145 ENLDPVVVQ------EGAPLTLQCNPP--------------PGLPSPVIFWMSSSMEPIT 184 L+ + Q + C+PP G SP W + P Sbjct: 593 GVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIP-- 650 Query: 185 QDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTP 244 V+ L V L+D + Y+C A + K LKVL + Sbjct: 651 ----VAYSLPPPLQIEKVDLRD-EGIYTCAAT---NLAGESKREVALKVLVPPNI----- 697 Query: 245 SFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFN-KALRI 303 + ++ VL + LEC+ASGVP PD++W+K + S + + + LRI Sbjct: 698 -----EPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRI 752 Query: 304 TNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDG--------R 355 D+G Y C+ASN GS +RV P + L P G R Sbjct: 753 EQAQLSDAGSYRCVASNVAGSTELRYGLRVNV-------PPRITLPPSLPGPVLVNTPVR 805 Query: 356 LVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV--AGDTIIFRDTQISSRAVYQCNTSNE 413 L C A G P PT+ W+ +G P+ A P +V G + + S Y C + Sbjct: 806 LTCNATGAPSPTLMWLKDGNPVSPA-GTPGLQVFPGGRVLTLASARASDSGRYSCVAVSA 864 Query: 414 HGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL 473 G + + V +PP +L + V+ L+C P P L W+K+G+ Sbjct: 865 VGEDRQDVVLQV-HMPPSILGEELN-VSVVANESVALECQSHAMPPPVLSWWKDGRPLEP 922 Query: 474 DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEV-KDPTRIYRMPEDQV 532 G + + L++ D G YTC A N G++E L V P R Sbjct: 923 RPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLT 982 Query: 533 ARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL---YIGNRMKKEDDSLTIFGVAE-RDQG 588 R G L C + P K +SW KD +PL G + L G A+ +G Sbjct: 983 VREGHPTSLSCECRGVPFPK--ISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEG 1040 Query: 589 SYTCVAS 595 +YTC S Sbjct: 1041 TYTCECS 1047 Score = 129 bits (324), Expect = 8e-30 Identities = 127/508 (25%), Positives = 200/508 (39%), Gaps = 44/508 (8%) Query: 40 PPTITKQSAKDHIVDPR-DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPR-----VSMR 93 PP+I + K ++ ++ +EC+A G P P W ++++ + + Sbjct: 94 PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 153 Query: 94 RRSGTLVIDF------------RSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPL 141 + G ++D RSG R + G Q A G A + + SP Sbjct: 154 QVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPP 213 Query: 142 WPKENLDPVVVQE-----GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGD 196 P L QE GA + LQC G+P+P + W + + +G Sbjct: 214 APPSVLGAGAAQEVLGLAGADVELQCWTS-GVPTPQVEWTKDRQPVLPGGPHLQVQEDGQ 272 Query: 197 LYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQ 256 + + Y C A F+ QQ F L+V P ++ Sbjct: 273 VLRITGSHVGDEGRYQCVA---FSPAGQQARDFQLRV--------HAPPTIWGSNETGEV 321 Query: 257 MVLRGMDLLLECIASGVPTPDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYF 315 V+ + L C A GVPTP+I W+K G LP S K + + L++ D+G Y Sbjct: 322 AVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYT 381 Query: 316 CLASNKMGSIRHTISVRVKAAPYWLD---EPKNLILAPGEDGRLVCRANGNPKPTVQWMV 372 C ASN +G+ + V P P + G L C A G+P PT+ W Sbjct: 382 CKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHH 441 Query: 373 NGEPLQSAPPNPNR-EVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPR 431 G P+ A N +R E G + +S +Y C S+ G + V V VPP+ Sbjct: 442 EGLPV--AESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEV-QVPPQ 498 Query: 432 MLSPRNQ-LIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKM 490 +L + I+ L C GSP+PT++W +NG+ + G + +L I Sbjct: 499 LLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDH 558 Query: 491 IRKEDQGIYTCVATNILGKAENQVRLEV 518 + + G++ C ATN G A +V + V Sbjct: 559 VELDHSGLFACQATNEAGTAGAEVEVSV 586 Score = 119 bits (299), Expect = 6e-27 Identities = 146/581 (25%), Positives = 230/581 (39%), Gaps = 48/581 (8%) Query: 63 CEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARN 122 C G P P W + + P V++ G+L F + P + G+Y+C A N Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEE-GSL---FLASVSPAD-SGDYECQATN 78 Query: 123 KFGTALSNRIRLQVSKSPLWPKENLDPVVV-QEGAPLTLQCNPPPGLPSPVIFWMSSSME 181 + G+ S R +L V P ++ V G LTL+C+ G P P I W+ + Sbjct: 79 EVGST-SRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDAN-GFPVPEIVWLKDAQ- 135 Query: 182 PITQDKRVSQGHNGDLYFSNV----MLQD--------MQTDYSCNARFHFTHTIQQKNPF 229 + G+ DL + V +L + +Q S + Q K P+ Sbjct: 136 -LVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPW 194 Query: 230 TLKVL------TTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYK- 282 + T + P + G A + L G D+ L+C SGVPTP + W K Sbjct: 195 XAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKD 254 Query: 283 KGGDLPSDK-AKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLD 341 + LP + + + LRIT D G Y C+A + G +RV A P Sbjct: 255 RQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWG 314 Query: 342 EPKNLILAPGEDG--RLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV---AGDTIIFR 396 + +A ED +L+C A G P P + W +G L P + V G + Sbjct: 315 SNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALL----PTSTKVVYTRGGRQLQLG 370 Query: 397 DTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRM--LSPRNQLIRVILYNRTRLDCPF 454 Q S VY C SN G + V VPP + R +++ + L+C Sbjct: 371 RAQSSDAGVYTCKASNAVGAAEKATRLDVY-VPPTIEGAGGRPYVVKAVAGRPVALECVA 429 Query: 455 FGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQV 514 G P PTL W G + + L ++ + G+Y+CVA++ G+A Q Sbjct: 430 RGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQY 489 Query: 515 RLEVKDPTRIYRMPE-DQVAR-RGTTVQLECRVKHDPSLKLTVSWLKDDEPL--YIGNRM 570 +EV+ P ++ QV G ++L C+ P T+ WL++ P G ++ Sbjct: 490 SVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSP--VPTIQWLQNGRPAEELAGVQV 547 Query: 571 KKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLG 611 + +L I V G + C A+ E A+ ++V G Sbjct: 548 ASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHG 588 Score = 119 bits (297), Expect = 1e-26 Identities = 102/396 (25%), Positives = 173/396 (43%), Gaps = 32/396 (8%) Query: 37 LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96 + Q P + + D + + C+A+G+P P+ W ++ + + A+ + S Sbjct: 2842 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTI--QPS 2899 Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 156 G L++ G + G Y C A N G A R+ L + P++ D + + G Sbjct: 2900 GELLVKNLEG----QDAGTYTCTAENAVGRA-RRRVHLTILVLPVFTTLPGDRSL-RLGD 2953 Query: 157 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA- 215 L L+C G P+P I W + P+T+ VS+ G + ++ Y C A Sbjct: 2954 RLWLRC-AARGSPTPRIGWTVND-RPVTEG--VSEQDGGSTLQRAAVSREDSGTYVCWAE 3009 Query: 216 -RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLR-GMDLLLECIASGV 273 R T + + VL QG A S +V G + L+C+ G Sbjct: 3010 NRVGRTQAVSFVHVKEAPVL---------------QGEAFSYLVEPVGGSIQLDCVVRGD 3054 Query: 274 PTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRV 333 P PDI W K G L + + N +L I +D+G Y CLA N+MG + + + + Sbjct: 3055 PVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVL 3114 Query: 334 KAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTI 393 ++AP + EP+++ + G+D L C+A G P PT++W+ G+PL+++ R + ++ Sbjct: 3115 QSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRAS--RRLRTLPDGSL 3172 Query: 394 IFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVP 429 + + Y C N G A AF+ V P Sbjct: 3173 WLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 3208 Score = 116 bits (291), Expect = 5e-26 Identities = 151/596 (25%), Positives = 229/596 (38%), Gaps = 54/596 (9%) Query: 40 PPTITKQSAKDHIVDPRDNIL-IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 98 PPTI + + D+++ + CEA+G P P+ W ++ + +V R Sbjct: 309 PPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGAL--LPTSTKVVYTRGGRQ 366 Query: 99 LVIDFRSGGRPEEYE-GEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQ--EG 155 L + GR + + G Y C A N G A RL V P P VV+ G Sbjct: 367 LQL-----GRAQSSDAGVYTCKASNAVGAA-EKATRLDVYVPPTIEGAGGRPYVVKAVAG 420 Query: 156 APLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA 215 P+ L+C G PSP + W + P+ + +G + + YSC A Sbjct: 421 RPVALEC-VARGHPSPTLSWHHEGL-PVAESNESRLETDGSVLRLESPGEASSGLYSCVA 478 Query: 216 RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 275 +P VL + P + +G ++ G L L C ASG P Sbjct: 479 ----------SSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIV-GQPLELPCQASGSPV 527 Query: 276 PDIAWYKKGGDLPSDK---AKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR 332 P I W + G P+++ + + L I +V + SG + C A+N+ G+ + V Sbjct: 528 PTIQWLQNG--RPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVS 585 Query: 333 VKA--APYWLDEP--------KNLILAPGEDGRLVCRANG-NPKPTV--QWMVNGEPLQS 379 V AP L+ P ++ P V R G +PKP + W G Sbjct: 586 VHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGE 645 Query: 380 APPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQL 439 P + + +Y C +N G + VL VPP + + Sbjct: 646 PTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVL-VPPNI--EPGPV 702 Query: 440 IRVILYNRT-RLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGI 498 + +L N + L+C G P P + WFK Q + G + L I+ + D G Sbjct: 703 NKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGS 762 Query: 499 YTCVATNILGKAENQVRLEVKDPTRIYRMPE-DQVARRGTTVQLECRVKHDPSLKLTVSW 557 Y CVA+N+ G E + L V P RI P T V+L C PS T+ W Sbjct: 763 YRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPS--PTLMW 820 Query: 558 LKDDEPL----YIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609 LKD P+ G ++ LT+ D G Y+CVA + + +D L V Sbjct: 821 LKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV 876 >gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] Length = 5065 Score = 181 bits (460), Expect = 1e-45 Identities = 165/587 (28%), Positives = 245/587 (41%), Gaps = 47/587 (8%) Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTR-NSRFFNIAKDPRVSMRRRSGT 98 PPTI D V +++ C + G PAP+ W++ ++ RVS SG Sbjct: 3856 PPTIADDQT-DFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSP---SGA 3911 Query: 99 LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLW-PKENLDPVVVQEGAP 157 L I G + G Y C ARN G A + L V SP+ P ++ V +E Sbjct: 3912 LEI----GQALPIHAGRYTCSARNSAGVA-HKHVFLTVQASPVVKPLPSVVRAVAEEEVL 3966 Query: 158 LTLQCNPPPGLPSPVIFWMSSSMEPITQ-DKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 216 L + + G+P P I W + T +V G G L ++ +D +Y C A Sbjct: 3967 LPCEAS---GIPRPTITWQKEGLNVATGVSTQVLPG--GQLRIAHASPEDAG-NYLCIA- 4019 Query: 217 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 276 KN + TR V + P + G L C A G P P Sbjct: 4020 ---------KNSAGSAMGKTRLVVQVPPVI---ENGLPDLSTTEGSHAFLPCKARGSPEP 4067 Query: 277 DIAWYKKGGDLPSDKAKFE-NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 335 +I W K G + + KF + L + N+ +D+G Y C A N +G R + + + Sbjct: 4068 NITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILV 4127 Query: 336 APYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIF 395 P + P + L G+ L C A G+P P + W VN P+ + + G T+ Sbjct: 4128 LPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV---SEQDGGSTLQR 4184 Query: 396 RDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFF 455 Y C N G A +FV V + P + L+ + +LDC Sbjct: 4185 AAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPV-GGSIQLDCVVR 4243 Query: 456 GSPIPTLRWFKNG---QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAEN 512 G P+P + W K+G +GS+L H +NGSL I ++D G Y C+A N +G A+ Sbjct: 4244 GDPVPDIHWIKDGLPLRGSHLR----HQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKK 4299 Query: 513 QVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKK 572 V L ++ P+D R G V L C+ +P+ T+ WL+ +PL R++ Sbjct: 4300 VVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPT--PTIEWLQAGQPLRASRRLRT 4357 Query: 573 -EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGNCPCSPW 618 D SL + V D G+Y CVA L A+A+L V G P W Sbjct: 4358 LPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGE-PQGSW 4403 Score = 161 bits (407), Expect = 2e-39 Identities = 152/569 (26%), Positives = 241/569 (42%), Gaps = 49/569 (8%) Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 99 PP + A + V P + ++ C G + W R+ R A RV+ + L Sbjct: 517 PPQLVP--APNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLP-ASTGRVA---QLADL 570 Query: 100 VIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLT 159 ++ SG P + G YQC A N G ++ + L V ++P + +G + Sbjct: 571 SLEI-SGIIPTD-GGRYQCVASNANGVTRAS-VWLLVREAPQ-VSIHTSSQHFSQGVEVK 626 Query: 160 LQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHF 219 + C+ G P+P I W S + + +D R+ G L V +D +YSC A Sbjct: 627 VSCSAS-GYPTPHISWSRES-QALQEDSRIHVDAQGTLIIQGVAPEDAG-NYSCQA---- 679 Query: 220 THTIQQKNPFTLKVLTTRGVAERTPSFMY---PQGTASSQMVLR--GMDLLLECIASGVP 274 T+ + G + T + Y P +A + +VL G + +L C ASGVP Sbjct: 680 TNEV--------------GTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVP 725 Query: 275 TPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVK 334 P + WY+ G L A + + LRI E D+G Y C A N++G I + V Sbjct: 726 PPRVIWYR--GGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVG 783 Query: 335 AAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMV-NGEPLQ----SAPPNPNREVA 389 AP + P+++ + G L CRA G P PTV W +G+PL + + +R+ Sbjct: 784 HAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPD 843 Query: 390 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR 449 + F +A Y C N G + A A + V P ++ +RV+ Sbjct: 844 SGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVS 903 Query: 450 LDCPFF-GSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILG 508 L C G P+P W K+G+ G + + +GSL + +E G Y+CVATN G Sbjct: 904 LPCIVLAGRPLPERHWLKDGRPLP-PGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAG 962 Query: 509 KAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYI-- 566 V L V+ P RI+ + G L C P+ T++W K+ L Sbjct: 963 SQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPA--PTITWTKETNALTSRG 1020 Query: 567 GNRMKKEDDSLTIFGVAERDQGSYTCVAS 595 + ++ +L I + +D G+Y C A+ Sbjct: 1021 PHYNVSKEGTLLIAQPSAQDAGAYVCTAT 1049 Score = 156 bits (395), Expect = 5e-38 Identities = 153/604 (25%), Positives = 252/604 (41%), Gaps = 55/604 (9%) Query: 41 PTI---TKQSAKDHIVDPRDN-ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96 PTI + SA + + +N I + CEA P+P+ W ++ F +++ ++ + Sbjct: 2537 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL-LPGTH 2595 Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNR-----IRLQVSKSPLWPKENLDPVV 151 G +++ + +E G+Y C N+ G A+ N I +SK + + V Sbjct: 2596 GLQILNAQ-----KEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVK 2650 Query: 152 VQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDY 211 + + LTL+C +P P I W +P+T R+ G L LQ T Sbjct: 2651 TKVNSTLTLECESW-AVPPPTIRWYKDG-QPVTPSSRLQVLGEGRL------LQIQPTQV 2702 Query: 212 SCNARFHFTHT------------IQQKNPFTLKVLTTRGVAERTPSFMYPQGTASS-QMV 258 S + R+ T + Q P KV E +G + + + Sbjct: 2703 SDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREI 2762 Query: 259 LRGMDLLLECIASGVPTPDIAWYKKGGDLPS-DKAKFENFNKALRITNVSEEDSGEYFCL 317 + L C + +P PD+ WY++ L + D+ + L+I V E++G Y C Sbjct: 2763 VENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCK 2822 Query: 318 ASNKMGSIRHTISVRVKAAPYWLDEPKNLI----LAPGEDGRLVCRANGNPKPTVQWMVN 373 ASN++G + V P L + + L+ + L C A GNP PT+ W+ N Sbjct: 2823 ASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQN 2882 Query: 374 GEPLQSAPPNPNREVAGDTIIFR--DTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPR 431 G P P+P +V D + + +++ A Y C N+ G F + VPPR Sbjct: 2883 GLPFS---PSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSA-EKLFTLRVQVPPR 2938 Query: 432 MLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMI 491 + + + IL + L C P P + W+K+ Q +L + + +L++ Sbjct: 2939 IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRA 2998 Query: 492 RKEDQGIYTCVATNILGKAENQVRLEVKDP---TRIYRMPEDQV-ARRGTTVQLECRVKH 547 R D G+YTC A N G+ + V+L V P + R P+D V R G L C Sbjct: 2999 RLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCET-- 3056 Query: 548 DPSLKLTVSWLKDDEPLYIGNRMK--KEDDSLTIFGVAERDQGSYTCVASTELDQDLAKA 605 D + TV+W KD +PL + R + + L I D+G Y+C S + + Sbjct: 3057 DALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTF 3116 Query: 606 YLTV 609 LTV Sbjct: 3117 TLTV 3120 Score = 156 bits (394), Expect = 6e-38 Identities = 152/563 (26%), Positives = 234/563 (41%), Gaps = 70/563 (12%) Query: 57 DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYE--- 113 D ++ CE P P+ W ++ + P V +R R G R E E Sbjct: 3048 DKAVLSCETDALPEPTVTWYKDGQ-------PLVLAQRTQA-----LRGGQRLEIQEAQV 3095 Query: 114 ---GEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPS 170 G Y C N G A+ L V P + + V G+PL L C+ G+P+ Sbjct: 3096 SDKGLYSCKVSNVAGEAVRT-FTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVS-GVPA 3153 Query: 171 PVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFT 230 P + W+ M + G L S + T Y+C A + + F Sbjct: 3154 PTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGT-YTCVAE---NTQAEARKDFV 3209 Query: 231 LKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSD 290 + VL VA R S G A VL G ++ L+C A G P PD+AW K G L D Sbjct: 3210 VAVL----VAPRIRS----SGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQD 3261 Query: 291 KAKFENF---NKALRITNVSEEDSGEYFCLASNKMG--SIRHTISVRV-KAAPYWLDEPK 344 F +L + + D+G Y C+A N G + HT++V V D Sbjct: 3262 MGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSG 3321 Query: 345 NLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV---AGDTIIFRDTQIS 401 L+ PGE +VC G+P V W+ +G PL P R + +G T+ Q++ Sbjct: 3322 TLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL----PLSQRTLLHGSGHTLRISKVQLA 3377 Query: 402 SRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSP---RNQLIRVILYNRTRLDCPFFGSP 458 ++ C ++ G N F + VPP +L P +N ++ V+ + L C G P Sbjct: 3378 DAGIFTCVAASPAGVADRN-FTLQVQVPP-VLEPVEFQNDVV-VVRGSLVELPCEARGVP 3434 Query: 459 IPTLRWFKNGQ---GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVR 515 +P + W K+G+ +L+ G SL+++ + D G Y+CVA + G+A + Sbjct: 3435 LPLVSWMKDGEPLLSQSLEQG-------PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQ 3487 Query: 516 LEVKDPTRI--YRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKE 573 L V +P I P + G ++L C + P +T W KD + L + E Sbjct: 3488 LTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNIT--WHKDGQAL-----TRLE 3540 Query: 574 DDSLTIFGVAERDQGSYTCVAST 596 ++S + RD G YTC+A + Sbjct: 3541 NNSRATRVLRVRDAGLYTCLAES 3563 Score = 152 bits (385), Expect = 7e-37 Identities = 144/563 (25%), Positives = 229/563 (40%), Gaps = 57/563 (10%) Query: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120 + C A+GNP P W+++ V ++ R + F + + G Y+C A Sbjct: 1139 LNCVAEGNPEPQLSWSKDG----------VVLQGRGPQGSVHFAAIRTSDA--GRYRCEA 1186 Query: 121 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQ-EGAPLTLQCNPPPGLPSPVIFWMSS- 178 N G + + L+V + P W + ++ + G +L C P G P P + W Sbjct: 1187 SNSAGVD-AWEVELRVLEPPHWGADETSGLLERVAGENASLPC-PARGTPKPQVTWRKGP 1244 Query: 179 SMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRG 238 S EP+ V+ G L+ ++V D DY C A T ++ Sbjct: 1245 SSEPLHGQPGVAVLEEGSLFLASVSPAD-SGDYECQATNEVGSTSRRAK----------- 1292 Query: 239 VAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK-------------GG 285 + P + G ++ + G L LEC A+G P P+I W K G Sbjct: 1293 LVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGW 1352 Query: 286 DLPSDKA---KFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDE 342 DL + + + ++L + E DSG Y C A N+ G+ + + V P L Sbjct: 1353 DLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGA 1412 Query: 343 --PKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQI 400 + ++ G D L C +G P P V+W + +P+ P+ + G + + + Sbjct: 1413 GAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHV 1472 Query: 401 SSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIP 460 YQC + G + + V P S + V+ + +L C G P P Sbjct: 1473 GDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTP 1532 Query: 461 TLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKE--DQGIYTCVATNILGKAENQVRLEV 518 + WFK+G + L VY G ++++ R + D G+YTC A+N +G AE RL+V Sbjct: 1533 NITWFKDG--ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV 1590 Query: 519 KDPTRIY---RMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDD 575 P I P A G V LEC + PS T+SW + P+ N + E D Sbjct: 1591 YVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPS--PTLSWHHEGLPVAESNESRLETD 1648 Query: 576 S--LTIFGVAERDQGSYTCVAST 596 L + E G Y+CVAS+ Sbjct: 1649 GSVLRLESPGEASSGLYSCVASS 1671 Score = 151 bits (382), Expect = 2e-36 Identities = 149/571 (26%), Positives = 230/571 (40%), Gaps = 37/571 (6%) Query: 40 PPTI---TKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96 PP I T++ ++ V+ + ++C A GNP P+ W +N F+ PR+ + Sbjct: 2841 PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFS--PSPRLQVLEDG 2898 Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 156 L + Y C A N+ G+A L+V P +L+ V + Sbjct: 2899 QVLQVSTAEVADA----ASYMCVAENQAGSA-EKLFTLRVQVPPRIAGLDLEQVTAILNS 2953 Query: 157 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 216 ++L C+ P+P + W S ++ L L D Y+C A Sbjct: 2954 SVSLPCDVHAH-PNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGM-YTCEA- 3010 Query: 217 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMY-PQGTASSQMVLRGMDLLLECIASGVPT 275 + + L VL P+F P+G + +V G +L C +P Sbjct: 3011 --LNAAGRDQKLVQLSVLVP-------PAFRQAPRGPQDAVLVRVGDKAVLSCETDALPE 3061 Query: 276 PDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVK 334 P + WYK G L + + + + L I D G Y C SN G T ++ V+ Sbjct: 3062 PTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQ 3121 Query: 335 AAPYWLDEPKNLILA--PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT 392 P + + PK ++ G L C +G P PTV W+ + P++S+ + G Sbjct: 3122 VPPTF-ENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRL 3180 Query: 393 IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDC 452 + R Q + Y C N + V+VL P S + V+ RLDC Sbjct: 3181 QLSR-LQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC 3239 Query: 453 PFFGSPIPTLRWFKNGQGSNLDGGNY--HVYENGSLEIKMIRKEDQGIYTCVATNILGKA 510 G P P + W K+G D G + + GSL +K +R D G YTCVA N G+ Sbjct: 3240 EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED 3299 Query: 511 ENQVRLEVKDPTRIYRMPEDQ---VARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIG 567 + V P I + + V+R G V + C V+ P + VSWLKD PL + Sbjct: 3300 ARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIH--VSWLKDGLPLPLS 3357 Query: 568 NR--MKKEDDSLTIFGVAERDQGSYTCVAST 596 R + +L I V D G +TCVA++ Sbjct: 3358 QRTLLHGSGHTLRISKVQLADAGIFTCVAAS 3388 Score = 150 bits (380), Expect = 3e-36 Identities = 144/580 (24%), Positives = 228/580 (39%), Gaps = 37/580 (6%) Query: 37 LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96 L P + A++H V + ++CEA G P P W ++ P + Sbjct: 3213 LVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDG 3272 Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFG-TALSNRIRLQVSKSPLWPKENLDPVVVQEG 155 G+LV+ G G Y C A N G A + + + V + + +V + G Sbjct: 3273 GSLVLK----GLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPG 3328 Query: 156 APLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA 215 +T+ C P G P + W+ + + + G L S V L D ++C A Sbjct: 3329 ELVTMVC-PVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGI-FTCVA 3386 Query: 216 RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 275 + +N FTL+V + P + P + +V+RG + L C A GVP Sbjct: 3387 A--SPAGVADRN-FTLQV--------QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPL 3435 Query: 276 PDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 335 P ++W K G L S + +L++ V DSG Y C+A ++ G R + V Sbjct: 3436 PLVSWMKDGEPLLSQSLE---QGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVME 3492 Query: 336 APYWLD--EPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTI 393 P+ D +P L L PG L+C A G P+P + W +G+ L N Sbjct: 3493 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRAT------ 3546 Query: 394 IFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRN-QLIRVILYNRTRLDC 452 R ++ +Y C + G + +F + PP ++ PR + + + + L+C Sbjct: 3547 --RVLRVRDAGLYTCLAESPAG-AIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLEC 3603 Query: 453 PFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAEN 512 P P + W ++G D L+++ + D G Y+C A N G Sbjct: 3604 SVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSV 3663 Query: 513 QVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKK 572 R+E+ I P T L C+ P+ VSW KD PL + + Sbjct: 3664 AFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPA--PLVSWRKDRVPLDPRSPRFE 3721 Query: 573 --EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 610 + SL I V +D G Y C+AS D L VL Sbjct: 3722 ILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVL 3761 Score = 150 bits (379), Expect = 3e-36 Identities = 148/591 (25%), Positives = 237/591 (40%), Gaps = 52/591 (8%) Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 99 PP IT + V + + C A G P+P+ W ++ + A P + + L Sbjct: 1976 PPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVL 2035 Query: 100 VIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLD-PVVVQEGAPL 158 + + R + G Y C A + G + + LQV P E L+ VV E L Sbjct: 2036 TL---ASARASD-SGRYSCVAVSAVGEDRQDVV-LQVHMPPSILGEELNVSVVANESVAL 2090 Query: 159 TLQCNPPPGLPSPVIFWMSSS--MEP-----ITQDKRVSQGHNGDLYFSNVMLQDMQTDY 211 Q + +P PV+ W +EP ++ DK + Q D++ + Y Sbjct: 2091 ECQSH---AMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAG--------HY 2139 Query: 212 SCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIAS 271 +C A H+ + N L V ++P + + V G L C Sbjct: 2140 TCEALNQAGHSEKHYN---LNVWVAP---------VFPLRESHTLTVREGHPTSLSCECR 2187 Query: 272 GVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEED---SGEYFCLASNKMGSIRHT 328 GVP P I+W K G LP + A ++ + R+ + + G Y C SN +G+ Sbjct: 2188 GVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQD 2247 Query: 329 ISVRVKAAPYWL---DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPN 385 + + V P + P + + L C A G P PTV W +G+P+ A Sbjct: 2248 LQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPV-GAELGLQ 2306 Query: 386 REVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQL--IRVI 443 + G ++ Q + Y C N G +SVL VPP ++ + L I Sbjct: 2307 LQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVL-VPPELIGDLDPLTNITAA 2365 Query: 444 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 503 L++ L C G P P +RWF+ + + Y + L++ +++D G+Y+C+A Sbjct: 2366 LHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLA 2425 Query: 504 TNILGKAENQVRLEVKDPTRIYRMPEDQVAR--RGTTVQLECRVKHDPSLKLTVSWLKDD 561 +N G+A +EV P I ++V + G T L C V P KLT W KD Sbjct: 2426 SNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLT--WFKDG 2483 Query: 562 EPLYIGNRMKKEDDS--LTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 610 PL G+ D L + G Y+C+A+ + + L+VL Sbjct: 2484 RPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVL 2534 Score = 149 bits (376), Expect = 7e-36 Identities = 152/581 (26%), Positives = 225/581 (38%), Gaps = 38/581 (6%) Query: 34 QNELTQPPTITKQSAKDHI-VDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSM 92 Q + +PP I + + P + + C+A+G P P+ W ++ + R+ Sbjct: 3487 QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALT-----RLEN 3541 Query: 93 RRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA-LSNRIRLQVSKSPLWPKENLDPVV 151 R+ T V+ R G Y C A + G S R+R+Q + + P+ V Sbjct: 3542 NSRA-TRVLRVRDAGL-------YTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVG 3593 Query: 152 VQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDY 211 + G L L+C+ P+P I W + + +D G + DY Sbjct: 3594 LAPGQ-LVLECSVEAE-PAPKITWHRDGIV-LQEDAHTQFPERGRFLQLQALSTADSGDY 3650 Query: 212 SCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIAS 271 SC AR T F +++ T + P+ V LL C A Sbjct: 3651 SCTARNAAGST---SVAFRVEIHTVPTIRSGPPAVN----------VSVNQTALLPCQAD 3697 Query: 272 GVPTPDIAWYKKGGDLPSDKAKFENFNK-ALRITNVSEEDSGEYFCLASNKMGSIRHTIS 330 GVP P ++W K L +FE + +LRI V +D+G Y CLASN GS R Sbjct: 3698 GVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRD 3757 Query: 331 VRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQ-SAPPNPNREVA 389 +RV P P NL L L C A+G+PKP V W +G+ L R + Sbjct: 3758 LRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLP 3817 Query: 390 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR 449 + ++ A ++C SNE G + + VPP + + V + Sbjct: 3818 SNALLLTAPGPQDSAQFECVVSNEVGE-AHRLYQVTVHVPPTIADDQTD-FTVTMMAPVV 3875 Query: 450 LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGK 509 L C G P PT+ W K G G Y V +G+LEI G YTC A N G Sbjct: 3876 LTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGV 3935 Query: 510 AENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIG-N 568 A V L V+ + +P A V L C P + T++W K+ + G + Sbjct: 3936 AHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIP--RPTITWQKEGLNVATGVS 3993 Query: 569 RMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609 L I + D G+Y C+A + K L V Sbjct: 3994 TQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVV 4034 Score = 143 bits (361), Expect = 4e-34 Identities = 154/581 (26%), Positives = 236/581 (40%), Gaps = 47/581 (8%) Query: 37 LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96 LT P + +A++ + ++ ++C G P P WT++ R + P + ++ Sbjct: 1404 LTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKD-RQPVLPGGPHLQVQEDG 1462 Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSP-LWPKENLDPVVVQEG 155 L R G EG YQC A + G + +L+V P +W V V E Sbjct: 1463 QVL----RITGSHVGDEGRYQCVAFSPAGQQ-ARDFQLRVHAPPTIWGSNETGEVAVMED 1517 Query: 156 APLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA 215 + L C G+P+P I W T K V L D Y+C A Sbjct: 1518 HLVQLLCE-ARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGV-YTCKA 1575 Query: 216 RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 275 N TR P+ G + G + LEC+A G P+ Sbjct: 1576 ----------SNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPS 1625 Query: 276 PDIAWYKKGGDLP---SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR 332 P ++W+ +G LP S++++ E LR+ + E SG Y C+AS+ G SV Sbjct: 1626 PTLSWHHEG--LPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVE 1683 Query: 333 VKAAPYWL--DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVA- 389 V+ P L + + G+ L C+A+G+P PT+QW+ NG P + +VA Sbjct: 1684 VQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEEL---AGVQVAS 1740 Query: 390 -GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLD--VPPRMLSPRNQLIRVILYN 446 G T+ ++ ++ C +NE G A VSV P + P Q ++ Sbjct: 1741 QGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHH 1800 Query: 447 RT---RLDCP----FFGSPIPTL--RWFKNGQGSNLDGGNYHVYE-NGSLEIKMIRKEDQ 496 + D P + P P L W G G Y L+I+ + D+ Sbjct: 1801 SSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDE 1860 Query: 497 GIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVS 556 GIYTC ATN+ G+++ +V L+V P I P ++ +V LEC P VS Sbjct: 1861 GIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVP--PPDVS 1918 Query: 557 WLKDDEPL--YIGNRMKKEDDSLTIFGVAERDQGSYTCVAS 595 W K +P+ ++G + + L I D GSY CVAS Sbjct: 1919 WFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVAS 1959 Score = 143 bits (360), Expect = 5e-34 Identities = 161/639 (25%), Positives = 241/639 (37%), Gaps = 105/639 (16%) Query: 38 TQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSG 97 T PP+++ +A + + +L+ CEA G P P W R +A + S + Sbjct: 695 TDPPSVSAVNAVVLVAVGEEAVLV-CEASGVPPPRVIWYRGGLEMILAPEGSSSGK---- 749 Query: 98 TLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAP 157 R E G Y C A N+ G A S I+L V +P + D V V+ G Sbjct: 750 -----LRIPAAQERDAGTYTCRAVNELGDA-SAEIQLAVGHAPQLTELPRD-VTVELGRS 802 Query: 158 LTLQCNPPPGLPSPVIFWMSSSMEPIT------QDKRVSQGHNGDLYFSNVMLQDMQTDY 211 L C G P P + W +P+ + R Q +G L+F +V +D Q Y Sbjct: 803 ALLACRAT-GRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPED-QAPY 860 Query: 212 SCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIA- 270 C AR F K +++ T + S +A + VL G + L CI Sbjct: 861 VCEARNVFG-----KVQAEARLIVTGHAPPQIAS------SAPTVRVLEGQPVSLPCIVL 909 Query: 271 SGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTIS 330 +G P P+ W K G LP + +L + +E +G Y C+A+N GS + Sbjct: 910 AGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVE 969 Query: 331 VRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAG 390 + V+ P + I G L C A+G P PT+ W L S P+ N G Sbjct: 970 LVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEG 1029 Query: 391 DTII----------------------------------------------------FRDT 398 +I Sbjct: 1030 TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQV 1089 Query: 399 QISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSP 458 Q+ Y+C SN G ++ +V + VPP+ + P ++++V++ L+C G+P Sbjct: 1090 QVGDSGHYECTASNPAG-SASHRYVLGVQVPPQ-VQPGPRVLKVLVGEALDLNCVAEGNP 1147 Query: 459 IPTLRWFKNG---QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVR 515 P L W K+G QG GS+ IR D G Y C A+N G +V Sbjct: 1148 EPQLSWSKDGVVLQGRG---------PQGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVE 1198 Query: 516 LEVKDPTRIYRMPEDQVARR--GTTVQLECRVKHDPSLKLTVSWLK--DDEPLYIGNRMK 571 L V +P + R G L C + P K V+W K EPL+ + Sbjct: 1199 LRVLEPPHWGADETSGLLERVAGENASLPCPARGTP--KPQVTWRKGPSSEPLHGQPGVA 1256 Query: 572 -KEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609 E+ SL + V+ D G Y C A+ E+ +A L V Sbjct: 1257 VLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVV 1295 Score = 143 bits (360), Expect = 5e-34 Identities = 145/562 (25%), Positives = 224/562 (39%), Gaps = 45/562 (8%) Query: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120 + CE +G P P W ++ + + + G L+ G EG Y C Sbjct: 2182 LSCECRGVPFPKISWRKDGQPLP-GEGAGLQHVSAVGRLLY---LGQAQLAQEGTYTCEC 2237 Query: 121 RNKFGTALSNRIRLQVSKSP--LWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSS 178 N G + S ++L+V P P+E V V + TL+CN G P P + W Sbjct: 2238 SNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNAT-GKPPPTVTWERD 2295 Query: 179 SMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRG 238 +P+ + + + G YSC A + ++K F L VL Sbjct: 2296 G-QPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAE-NLAGRAERK--FELSVLVP-- 2349 Query: 239 VAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDL-PSDKAKFENF 297 P + ++ L L C A G+P P I W++ + P + Sbjct: 2350 -----PELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAG 2404 Query: 298 NKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA--PGEDGR 355 L++T E+DSG Y CLASN+ G R SV V P +E ++ G+ Sbjct: 2405 GWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAH 2464 Query: 356 LVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQ--ISSRAVYQCNTSNE 413 L+C G+P+P + W +G PL + ++ D ++ + Q +SS Y C +N Sbjct: 2465 LMCNVTGHPQPKLTWFKDGRPLARGDAH---HISPDGVLLQVLQANLSSAGHYSCIAANA 2521 Query: 414 HGYLLANAFVSVLDVPPRMLSPRNQL---IRVILYNRTRLDCPFFGSPIPTLRWFKNGQG 470 G + +SVL P + + + V + N L C P P + W K+G Sbjct: 2522 VGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAP 2581 Query: 471 SNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPED 530 + L+I +KED G YTCV TN LG+A +EV P I + +D Sbjct: 2582 FEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISK--DD 2639 Query: 531 QVARRG---------TTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK--KEDDSLTI 579 + G +T+ LEC P T+ W KD +P+ +R++ E L I Sbjct: 2640 PLGEVGVKEVKTKVNSTLTLECESWAVP--PPTIRWYKDGQPVTPSSRLQVLGEGRLLQI 2697 Query: 580 FGVAERDQGSYTCVASTELDQD 601 D G Y CVA+ +D Sbjct: 2698 QPTQVSDSGRYLCVATNVAGED 2719 Score = 141 bits (356), Expect = 2e-33 Identities = 156/628 (24%), Positives = 253/628 (40%), Gaps = 86/628 (13%) Query: 33 IQNELTQPPTIT-KQSAKDHIVDPRDNIL-IECEAKGNPAPSFHWTRNSRFFNIAKDPRV 90 +Q E+ PP I + + +D + +EC A G P P+ W R+ + + + + Sbjct: 2248 LQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQ--PVGAELGL 2305 Query: 91 SMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKE---NL 147 ++ + +L ++ + G Y C A N L+ R + S L P E +L Sbjct: 2306 QLQNQGQSLHVERAQAA----HTGRYSCVAEN-----LAGRAERKFELSVLVPPELIGDL 2356 Query: 148 DPVVVQEGA---PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVML 204 DP+ A PLTL C G+P P I W EP VS G + L ML Sbjct: 2357 DPLTNITAALHSPLTLLCEAM-GIPPPAIRWFRGE-EP------VSPGEDTYLLAGGWML 2408 Query: 205 QDMQTD------YSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMV 258 + QT YSC A + + F+++VL P + + V Sbjct: 2409 KMTQTQEQDSGLYSCLAS---NEAGEARRNFSVEVLV--------PPSIENEDLEEVIKV 2457 Query: 259 LRGMDLLLECIASGVPTPDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCL 317 L G L C +G P P + W+K G L D L++ + +G Y C+ Sbjct: 2458 LDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCI 2517 Query: 318 ASNKMGSIRHTISVRVKAAPYWL-----DEPKNLILAPGEDGRLVCRANGNPKPTVQWMV 372 A+N +G + V AP L + + + L+C A P P + WM Sbjct: 2518 AANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMK 2577 Query: 373 NGEPLQSAPPNPNREVAGDT--IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPP 430 +G P +++ N ++ T + + Q Y C +NE G + N V VL +PP Sbjct: 2578 DGAPFEASR---NIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL-IPP 2633 Query: 431 RMLS--PRNQL----IRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENG 484 + P ++ ++ + + L+C + P PT+RW+K+GQ + E Sbjct: 2634 SISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGR 2693 Query: 485 SLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYR----------MPEDQVAR 534 L+I+ + D G Y CVATN+ G+ + + ++ P + + ++ AR Sbjct: 2694 LLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEAR 2753 Query: 535 RGTT----------VQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK--KEDDSLTIFGV 582 G T L C P LT W ++D+PL G+ + + L I V Sbjct: 2754 GGVTEYREIVENNPAYLYCDTNAIPPPDLT--WYREDQPLSAGDEVSVLQGGRVLQIPLV 2811 Query: 583 AERDQGSYTCVASTELDQDLAKAYLTVL 610 + G Y+C AS E+ +D L VL Sbjct: 2812 RAENAGRYSCKASNEVGEDWLHYELLVL 2839 Score = 140 bits (352), Expect = 5e-33 Identities = 160/647 (24%), Positives = 245/647 (37%), Gaps = 94/647 (14%) Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 99 PP I + +++ + L G P P HW ++ R + R S+R G+L Sbjct: 884 PPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGR--PLPPGSRHSIRA-DGSL 940 Query: 100 VIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV----VVQEG 155 +D +E+ G Y C A N G+ + + L V P + P + EG Sbjct: 941 HLDRAL----QEHAGRYSCVATNTAGSQHRD-VELVVQVPP-----RIHPTATHHITNEG 990 Query: 156 APLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA 215 P +L C G+P+P I W + ++ + G L + QD Y C A Sbjct: 991 VPASLPC-VASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGA-YVCTA 1048 Query: 216 RFHFTHTIQQKNPFTLKVLTTRGVAER---TPSFMY-------------------PQGTA 253 + Q+ ++ ++ V E PS P G+A Sbjct: 1049 TNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSA 1108 Query: 254 SSQMVLR------------------GMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFE 295 S + VL G L L C+A G P P ++W K G L + Sbjct: 1109 SHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRGPQGS 1168 Query: 296 NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYW-LDEPKNLI-LAPGED 353 A+R + D+G Y C ASN G + +RV P+W DE L+ GE+ Sbjct: 1169 VHFAAIRTS-----DAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGEN 1223 Query: 354 GRLVCRANGNPKPTVQWM--VNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTS 411 L C A G PKP V W + EPL P E ++ + Y+C + Sbjct: 1224 ASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEG--SLFLASVSPADSGDYECQAT 1281 Query: 412 NEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ-- 469 NE G A + V P R + + L+C G P+P + W K+ Q Sbjct: 1282 NEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLV 1341 Query: 470 -------------GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRL 516 G GG+ + E SL I++ D G+Y+C A N G A+ L Sbjct: 1342 GVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHL 1401 Query: 517 EVKDPTRIY--RMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGN---RMK 571 V P + ++ + G V+L+C P+ + V W KD +P+ G +++ Sbjct: 1402 LVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQ--VEWTKDRQPVLPGGPHLQVQ 1459 Query: 572 KEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGNCPCSPW 618 ++ L I G D+G Y CVA + Q L V + P + W Sbjct: 1460 EDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRV--HAPPTIW 1504 Score = 137 bits (344), Expect = 4e-32 Identities = 156/620 (25%), Positives = 248/620 (40%), Gaps = 63/620 (10%) Query: 24 AIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFN 83 ++E+ + PSI+NE + H++ C G+P P W ++ R Sbjct: 2437 SVEVLVPPSIENEDLEEVIKVLDGQTAHLM---------CNVTGHPQPKLTWFKDGRPLA 2487 Query: 84 IAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPL-- 141 +S G L+ ++ G Y C A N G + +L V +P Sbjct: 2488 RGDAHHISP---DGVLLQVLQAN---LSSAGHYSCIAANAVGEK-TKHFQLSVLLAPTIL 2540 Query: 142 -WPKENLDP-VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSME-PITQDKRVSQGHNGDLY 198 +++ D V V P++L C PSP I WM +++ ++ G +G L Sbjct: 2541 GGAEDSADEEVTVTVNNPISLICEAL-AFPSPNITWMKDGAPFEASRNIQLLPGTHG-LQ 2598 Query: 199 FSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMV 258 N +D Y+C ++ + ++VL +++ P +++ Sbjct: 2599 ILNAQKEDAG-QYTCVVTNELGEAVKN---YHVEVLIPPSISKDDPLGEVGVKEVKTKV- 2653 Query: 259 LRGMDLLLECIASGVPTPDIAWYKKGGDL-PSDKAKFENFNKALRITNVSEEDSGEYFCL 317 L LEC + VP P I WYK G + PS + + + L+I DSG Y C+ Sbjct: 2654 --NSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCV 2711 Query: 318 ASNKMGSIRHTISVRVKAAPYWLD----EPKNLILAPGEDGR----------------LV 357 A+N G +V ++ P + IL+ E+ R L Sbjct: 2712 ATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLY 2771 Query: 358 CRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYL 417 C N P P + W +PL SA + G + + + Y C SNE G Sbjct: 2772 CDTNAIPPPDLTWYREDQPL-SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGED 2830 Query: 418 LANAFVSVLDVPPRMLSPRNQLIRVILYNRTR---LDCPFFGSPIPTLRWFKNGQGSNLD 474 + + VL PP +L +L+ + N + L CP G+P+PT+ W +NG + Sbjct: 2831 WLHYELLVL-TPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFS-P 2888 Query: 475 GGNYHVYENGS-LEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQV- 532 V E+G L++ D Y CVA N G AE L V+ P RI + +QV Sbjct: 2889 SPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVT 2948 Query: 533 ARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTI-FGVAE-RDQGSY 590 A ++V L C V P+ ++T W KD + L +G + + T+ G A D G Y Sbjct: 2949 AILNSSVSLPCDVHAHPNPEVT--WYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMY 3006 Query: 591 TCVASTELDQDLAKAYLTVL 610 TC A +D L+VL Sbjct: 3007 TCEALNAAGRDQKLVQLSVL 3026 Score = 135 bits (341), Expect = 9e-32 Identities = 125/495 (25%), Positives = 203/495 (41%), Gaps = 31/495 (6%) Query: 40 PPTITKQSAKDHIVDPR-DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPR-----VSMR 93 PP+I + K ++ ++ +EC+A G P P W ++++ + + Sbjct: 1298 PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 1357 Query: 94 RRSGTLVIDF-RSGGRPEEYEGE---YQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP 149 + G ++D +S P EG+ Y C A N+ GTA + L ++ + Sbjct: 1358 QVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQE 1417 Query: 150 VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQT 209 V+ GA + LQC G+P+P + W + + +G + + Sbjct: 1418 VLGLAGADVELQCWTS-GVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEG 1476 Query: 210 DYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECI 269 Y C A F+ QQ F L+V P ++ V+ + L C Sbjct: 1477 RYQCVA---FSPAGQQARDFQLRV--------HAPPTIWGSNETGEVAVMEDHLVQLLCE 1525 Query: 270 ASGVPTPDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHT 328 A GVPTP+I W+K G LP S K + + L++ D+G Y C ASN +G+ Sbjct: 1526 ARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKA 1585 Query: 329 ISVRVKAAPYWLD---EPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPN 385 + V P P + G L C A G+P PT+ W G P+ A N + Sbjct: 1586 TRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPV--AESNES 1643 Query: 386 R-EVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQ-LIRVI 443 R E G + +S +Y C S+ G + V V VPP++L + I Sbjct: 1644 RLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEV-QVPPQLLVAEGLGQVTTI 1702 Query: 444 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 503 + L C GSP+PT++W +NG+ + G + +L I + + G++ C A Sbjct: 1703 VGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQA 1762 Query: 504 TNILGKAENQVRLEV 518 TN G A +V + V Sbjct: 1763 TNEAGTAGAEVEVSV 1777 Score = 132 bits (333), Expect = 7e-31 Identities = 153/607 (25%), Positives = 230/607 (37%), Gaps = 88/607 (14%) Query: 25 IEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNI 84 +++P + L Q TI Q + + C+A G+P P+ W +N R Sbjct: 1684 VQVPPQLLVAEGLGQVTTIVGQPLE-----------LPCQASGSPVPTIQWLQNGR--PA 1730 Query: 85 AKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPK 144 + V + + TL ID ++ G + C A N+ GTA + ++VS W Sbjct: 1731 EELAGVQVASQGTTLHIDHVE----LDHSGLFACQATNEAGTAGAE---VEVSVHGEWAP 1783 Query: 145 ENLDPVVVQ------EGAPLTLQCNPP--------------PGLPSPVIFWMSSSMEPIT 184 L+ + Q + C+PP G SP W + P Sbjct: 1784 GVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIP-- 1841 Query: 185 QDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTP 244 V+ L V L+D + Y+C A + K LKVL + Sbjct: 1842 ----VAYSLPPPLQIEKVDLRD-EGIYTCAAT---NLAGESKREVALKVLVPPNI----- 1888 Query: 245 SFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFN-KALRI 303 + ++ VL + LEC+ASGVP PD++W+K + S + + + LRI Sbjct: 1889 -----EPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRI 1943 Query: 304 TNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDG--------R 355 D+G Y C+ASN GS +RV P + L P G R Sbjct: 1944 EQAQLSDAGSYRCVASNVAGSTELRYGLRVNV-------PPRITLPPSLPGPVLVNTPVR 1996 Query: 356 LVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV--AGDTIIFRDTQISSRAVYQCNTSNE 413 L C A G P PT+ W+ +G P+ A P +V G + + S Y C + Sbjct: 1997 LTCNATGAPSPTLMWLKDGNPVSPA-GTPGLQVFPGGRVLTLASARASDSGRYSCVAVSA 2055 Query: 414 HGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL 473 G + + V +PP +L + V+ L+C P P L W+K+G+ Sbjct: 2056 VGEDRQDVVLQV-HMPPSILGEELN-VSVVANESVALECQSHAMPPPVLSWWKDGRPLEP 2113 Query: 474 DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEV-KDPTRIYRMPEDQV 532 G + + L++ D G YTC A N G +E L V P R Sbjct: 2114 RPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLT 2173 Query: 533 ARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL---YIGNRMKKEDDSLTIFGVAE-RDQG 588 R G L C + P K +SW KD +PL G + L G A+ +G Sbjct: 2174 VREGHPTSLSCECRGVPFPK--ISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEG 2231 Query: 589 SYTCVAS 595 +YTC S Sbjct: 2232 TYTCECS 2238 Score = 132 bits (331), Expect = 1e-30 Identities = 151/582 (25%), Positives = 240/582 (41%), Gaps = 51/582 (8%) Query: 57 DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEY 116 +N + C A+G P P W + + P V++ G+L F + P + G+Y Sbjct: 1222 ENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEE-GSL---FLASVSPAD-SGDY 1276 Query: 117 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVV-QEGAPLTLQCNPPPGLPSPVIFW 175 +C A N+ G+ S R +L V P ++ V G LTL+C+ G P P I W Sbjct: 1277 ECQATNEVGST-SRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDAN-GFPVPEIVW 1334 Query: 176 MSSSMEPITQDKRVSQGHNGDLYFSNV----MLQDMQTDYSCNARFHFTHTIQQKNP--F 229 + + + G+ DL + V +L + Q+ HF IQ+ + + Sbjct: 1335 LKDAQ--LVGVPLGWAGYGWDLGWGQVGGHRLLDEGQS-------LHFPR-IQEGDSGLY 1384 Query: 230 TLKVLTTRGVAER-------TPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYK 282 + + G A+R TP + G A + L G D+ L+C SGVPTP + W K Sbjct: 1385 SCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTK 1444 Query: 283 -KGGDLPSDK-AKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWL 340 + LP + + + LRIT D G Y C+A + G +RV A P Sbjct: 1445 DRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIW 1504 Query: 341 DEPKNLILAPGEDG--RLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV---AGDTIIF 395 + +A ED +L+C A G P P + W +G L P + V G + Sbjct: 1505 GSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALL----PTSTKVVYTRGGRQLQL 1560 Query: 396 RDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRM--LSPRNQLIRVILYNRTRLDCP 453 Q S VY C SN G + V VPP + R +++ + L+C Sbjct: 1561 GRAQSSDAGVYTCKASNAVGAAEKATRLDVY-VPPTIEGAGGRPYVVKAVAGRPVALECV 1619 Query: 454 FFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQ 513 G P PTL W G + + L ++ + G+Y+CVA++ G+A Q Sbjct: 1620 ARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQ 1679 Query: 514 VRLEVKDPTRIYRMPE-DQVAR-RGTTVQLECRVKHDPSLKLTVSWLKDDEPL--YIGNR 569 +EV+ P ++ QV G ++L C+ P T+ WL++ P G + Sbjct: 1680 YSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSP--VPTIQWLQNGRPAEELAGVQ 1737 Query: 570 MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLG 611 + + +L I V G + C A+ E A+ ++V G Sbjct: 1738 VASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHG 1779 Score = 121 bits (303), Expect = 2e-27 Identities = 99/373 (26%), Positives = 159/373 (42%), Gaps = 22/373 (5%) Query: 253 ASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENF-NKALRITNVSEEDS 311 A + V G +L C G ++ W + LP+ + + +L I+ + D Sbjct: 523 APNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDG 582 Query: 312 GEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWM 371 G Y C+ASN G R ++ + V+ AP + + G + ++ C A+G P P + W Sbjct: 583 GRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWS 642 Query: 372 VNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPR 431 + LQ + A T+I + Y C +NE G V++ P Sbjct: 643 RESQALQE--DSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVG--TDQETVTLYYTDPP 698 Query: 432 MLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL--DGGNYHVYENGSLEIK 489 +S N ++ V + L C G P P + W++ G L +G + +G L I Sbjct: 699 SVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSS-----SGKLRIP 753 Query: 490 MIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDP 549 ++ D G YTC A N LG A +++L V ++ +P D G + L CR P Sbjct: 754 AAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRP 813 Query: 550 SLKLTVSWLKDD-EPLYI------GNRMKKEDDSLTIF-GVAERDQGSYTCVASTELDQD 601 TV+W + D +PL + G+R ++ D + F VA DQ Y C A + Sbjct: 814 PP--TVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKV 871 Query: 602 LAKAYLTVLGNCP 614 A+A L V G+ P Sbjct: 872 QAEARLIVTGHAP 884 Score = 119 bits (297), Expect = 1e-26 Identities = 102/396 (25%), Positives = 173/396 (43%), Gaps = 32/396 (8%) Query: 37 LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96 + Q P + + D + + C+A+G+P P+ W ++ + + A+ + S Sbjct: 4033 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTI--QPS 4090 Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 156 G L++ G + G Y C A N G A R+ L + P++ D + + G Sbjct: 4091 GELLVKNLEG----QDAGTYTCTAENAVGRA-RRRVHLTILVLPVFTTLPGDRSL-RLGD 4144 Query: 157 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA- 215 L L+C G P+P I W + P+T+ VS+ G + ++ Y C A Sbjct: 4145 RLWLRC-AARGSPTPRIGWTVND-RPVTEG--VSEQDGGSTLQRAAVSREDSGTYVCWAE 4200 Query: 216 -RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLR-GMDLLLECIASGV 273 R T + + VL QG A S +V G + L+C+ G Sbjct: 4201 NRVGRTQAVSFVHVKEAPVL---------------QGEAFSYLVEPVGGSIQLDCVVRGD 4245 Query: 274 PTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRV 333 P PDI W K G L + + N +L I +D+G Y CLA N+MG + + + + Sbjct: 4246 PVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVL 4305 Query: 334 KAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTI 393 ++AP + EP+++ + G+D L C+A G P PT++W+ G+PL+++ R + ++ Sbjct: 4306 QSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRAS--RRLRTLPDGSL 4363 Query: 394 IFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVP 429 + + Y C N G A AF+ V P Sbjct: 4364 WLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 4399 Score = 115 bits (288), Expect = 1e-25 Identities = 125/494 (25%), Positives = 193/494 (39%), Gaps = 50/494 (10%) Query: 39 QPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 98 + P ++ ++ H + + + C A G P P W+R S+ + +D R+ + + GT Sbjct: 606 EAPQVSIHTSSQHFSQGVE-VKVSCSASGYPTPHISWSRESQA--LQEDSRIHVDAQ-GT 661 Query: 99 LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPL 158 L+I G PE+ G Y C A N+ GT + L + P N V+V G Sbjct: 662 LIIQ---GVAPED-AGNYSCQATNEVGTD-QETVTLYYTDPPSVSAVNA-VVLVAVGEEA 715 Query: 159 TLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFH 218 L C G+P P + W +E I + S +G L +D T Y+C A Sbjct: 716 VLVCEAS-GVPPPRVIWYRGGLEMILAPEGSS---SGKLRIPAAQERDAGT-YTCRA--- 767 Query: 219 FTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDI 278 + + + ++ G A + P+ V G LL C A+G P P + Sbjct: 768 ----VNELGDASAEIQLAVGHAPQLTEL--PRDVT----VELGRSALLACRATGRPPPTV 817 Query: 279 AWYKKGGD-------LPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISV 331 W + G + + L +V+ ED Y C A N G ++ + Sbjct: 818 TWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARL 877 Query: 332 RVK--AAPYWLDEPKNLILAPGEDGRLVCRA-NGNPKPTVQWMVNGEPLQSAPPNPNREV 388 V A P + + G+ L C G P P W+ +G PL PP + Sbjct: 878 IVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPL---PPGSRHSI 934 Query: 389 AGDTIIFRDTQISSRAV-YQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNR 447 D + D + A Y C +N G + + V+ VPPR+ I N Sbjct: 935 RADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVEL-VVQVPPRIHPTATHHIT----NE 989 Query: 448 ---TRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVAT 504 L C G P PT+ W K G +Y+V + G+L I +D G Y C AT Sbjct: 990 GVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTAT 1049 Query: 505 NILGKAENQVRLEV 518 N +G + ++RL V Sbjct: 1050 NTVGFSSQEMRLSV 1063 Score = 95.1 bits (235), Expect = 2e-19 Identities = 84/322 (26%), Positives = 132/322 (40%), Gaps = 12/322 (3%) Query: 295 ENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDG 354 E+ N + I S+ + G Y C A ++ G+ R + V P L N+ ++PGE Sbjct: 475 ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETA 534 Query: 355 RLVCRANGNPKPTVQWMVNGEPLQSAPPNPNR--EVAGDTIIFRDTQISSRAVYQCNTSN 412 L CR G + W+ + L P + R ++A ++ + YQC SN Sbjct: 535 VLSCRVLGEAPYNLTWVRDWRVL---PASTGRVAQLADLSLEISGIIPTDGGRYQCVASN 591 Query: 413 EHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSN 472 +G A+ ++ V + P + +Q + ++ C G P P + W + Q Sbjct: 592 ANGVTRASVWLLVREAPQVSIHTSSQHFSQGV--EVKVSCSASGYPTPHISWSRESQALQ 649 Query: 473 LDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQV 532 D HV G+L I+ + ED G Y+C ATN +G + V L DP + + + Sbjct: 650 ED-SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVL 708 Query: 533 ARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTC 592 G L C P + V W + + + L I ERD G+YTC Sbjct: 709 VAVGEEAVLVCEASGVPPPR--VIWYRGGLEMILAPE-GSSSGKLRIPAAQERDAGTYTC 765 Query: 593 VASTELDQDLAKAYLTVLGNCP 614 A EL A+ L V G+ P Sbjct: 766 RAVNELGDASAEIQLAV-GHAP 786 Score = 54.3 bits (129), Expect = 3e-07 Identities = 43/155 (27%), Positives = 62/155 (40%), Gaps = 4/155 (2%) Query: 457 SPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRL 516 S +P + G+ + ++ N S EI K ++G Y C A + G + ++ Sbjct: 452 SALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQI 511 Query: 517 EVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDE--PLYIGNRMKKED 574 V DP + G T L CRV + LT W++D P G + D Sbjct: 512 VVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLT--WVRDWRVLPASTGRVAQLAD 569 Query: 575 DSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609 SL I G+ D G Y CVAS A +L V Sbjct: 570 LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLV 604 >gi|118572606 hemicentin 1 [Homo sapiens] Length = 5635 Score = 180 bits (456), Expect = 4e-45 Identities = 165/585 (28%), Positives = 245/585 (41%), Gaps = 40/585 (6%) Query: 39 QPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 98 +PP I Q ++ H++ + IL+ CEA G P+P W + N+ R SG Sbjct: 3986 EPPVIQPQPSELHVI-LNNPILLPCEATGTPSPFITWQKEG--INVNTSGRNHAVLPSGG 4042 Query: 99 LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPL 158 L I E G Y C A+N GTAL +I+L V P+ +L V+ P+ Sbjct: 4043 LQIS----RAVREDAGTYMCVAQNPAGTALG-KIKLNVQVPPVI-SPHLKEYVIAVDKPI 4096 Query: 159 TLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFH 218 TL C GLP P I W I + R +G L + V D Y+C A Sbjct: 4097 TLSCEAD-GLPPPDITWHKDG-RAIVESIRQRVLSSGSLQIAFVQPGDAG-HYTCMAA-- 4151 Query: 219 FTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDI 278 N +T+ P + T V +L C+A G+PTP I Sbjct: 4152 --------NVAGSSSTSTKLTVHVPPRI---RSTEGHYTVNENSQAILPCVADGIPTPAI 4200 Query: 279 AWYKKGGDLPSDKAKF--ENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAA 336 W K L + K+ E + + + + NV EDSG Y C+A+N G HT+S+ V Sbjct: 4201 NWKKDNVLLANLLGKYTAEPYGELI-LENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVL 4259 Query: 337 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGE--PLQSAPPNPNREVAGDTII 394 P + + P ++ L GE RL C+A G P P + W N P N + E+ + + Sbjct: 4260 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVS 4319 Query: 395 FRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPF 454 D+ Y C N G++ A FV V + P + I + N L+C Sbjct: 4320 KEDS-----GTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAI-LNCEV 4373 Query: 455 FGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQV 514 G P PT++W + G + NGSL I ED G YTCVATN G E + Sbjct: 4374 KGDPTPTIQWNRKGVDIEISH-RIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSM 4432 Query: 515 RLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK-KE 573 L ++ P I P + V G + L C+ +P + T++W + + +R+ Sbjct: 4433 SLTLQSPPIITLEPVETVINAGGKIILNCQATGEP--QPTITWSRQGHSISWDDRVNVLS 4490 Query: 574 DDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGNCPCSPW 618 ++SL I + D + CVA + L + + V + S W Sbjct: 4491 NNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQW 4535 Score = 178 bits (451), Expect = 1e-44 Identities = 157/589 (26%), Positives = 256/589 (43%), Gaps = 60/589 (10%) Query: 36 ELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRN------SRFFNIAKDPR 89 ++ PP ++ A D ++ N+ + C +G P P+ W R SR F+++ Sbjct: 788 DVGSPPVFIQEPA-DVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSS--- 843 Query: 90 VSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP 149 +S R +++ + + G Y C A N+FG + + + V+ + P + P Sbjct: 844 ISQLRTGALFILNLWASDK-----GTYICEAENQFGK-IQSETTVTVT-GLVAPLIGISP 896 Query: 150 VV--VQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDM 207 V V EG LTL C G P P W+ +S + Q+ ++ +G L+ V LQD Sbjct: 897 SVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAM-LLQNPYITVRSDGSLHIERVQLQD- 954 Query: 208 QTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLE 267 +Y+C A N TT V P+ + Q S+ + G+ + L Sbjct: 955 GGEYTCVA----------SNVAGTNNKTTSVVVHVLPTIQHGQQILST---IEGIPVTLP 1001 Query: 268 CIASGVPTPDIAWYKKGGDLPSDKAKFE-NFNKALRITNVSEEDSGEYFCLASNKMGSIR 326 C ASG P P + W KKG + + AKF + +L + + E+SGEY C A+N G + Sbjct: 1002 CKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAK 1061 Query: 327 HTISVRVKAAPYWL--------DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQ 378 + + V P D+P + + GE+ L C P P + W + + Sbjct: 1062 RKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLIS 1121 Query: 379 SAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQ 438 P +G I +T+ S +Y C +N G + ++V VPP++ Sbjct: 1122 PFSPRHTFLPSGSMKI-TETRTSDSGMYLCVATNIAGNVTQAVKLNV-HVPPKIQRGPKH 1179 Query: 439 LIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGI 498 L +V + R + C G+P+P + W K G +DG ++ +G+L I D GI Sbjct: 1180 L-KVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGI 1238 Query: 499 YTCVATNILGKAENQVRLEVKDPTRIYRMP-------EDQVARRGTTVQLECRVKHDPSL 551 YTCVATNI G E ++ L V++P + + +++VA + ++ C K P Sbjct: 1239 YTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQ--RIEFPCPAKGTP-- 1294 Query: 552 KLTVSWLKDDEPL---YIGNRMKKEDDSLTIFGVAERDQGSYTCVASTE 597 K T+ WL + L G + ++ L I V D G Y CVA E Sbjct: 1295 KPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNE 1343 Score = 172 bits (435), Expect = 1e-42 Identities = 155/569 (27%), Positives = 240/569 (42%), Gaps = 42/569 (7%) Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 99 PPTI + +V + ++C A G P PS W ++ + N A+ +++ +S Sbjct: 1825 PPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQG---NLKIQSSGR 1881 Query: 100 VIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSP-LWPKENLDPVVVQEGAPL 158 V+ E G Y C A N G I+L V + P L + V P+ Sbjct: 1882 VLQIAK--TLLEDAGRYTCVATNAAGET-QQHIQLHVHEPPSLEDAGKMLNETVLVSNPV 1938 Query: 159 TLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFH 218 L+C G P PVI W +D R+ G + + + D+++ +A + Sbjct: 1939 QLECKAA-GNPVPVITWY--------KDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIY 1989 Query: 219 FTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDI 278 I L VA PS G+ + V+ + LEC A G+P P + Sbjct: 1990 KCVAINSAGATELFYSLQVHVA---PSI---SGSNNMVAVVVNNPVRLECEARGIPAPSL 2043 Query: 279 AWYKKGGDLPSDKAKFENFN--KALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAA 336 W K G + S + + + L +T+ D+G Y C+A N G + I +RV Sbjct: 2044 TWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVP 2103 Query: 337 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPP---NPNREVAGDTI 393 P + E +N+ + + L+C+++ P PT+ W+ +G PL P + NR V + Sbjct: 2104 PNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSV----L 2159 Query: 394 IFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVILYNRTRLDC 452 D Q+ Y C +N G N V++ VPP + S + VI N L C Sbjct: 2160 KIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIW-VPPNIGGSDELTQLTVIEGNLISLLC 2218 Query: 453 PFFGSPIPTLRWFKNGQGSNLDG-GNYHVYENG-SLEIKMIRKEDQGIYTCVATNILGKA 510 G P P L W K G D G + G L+I + K D +Y+CVA+N+ G A Sbjct: 2219 ESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTA 2278 Query: 511 ENQVRLEV---KDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLY-- 565 + + L+V T P + + RG ++ LEC V+ P TV+W+KD PL Sbjct: 2279 KKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIP--PPTVTWMKDGHPLIKA 2336 Query: 566 IGNRMKKEDDSLTIFGVAERDQGSYTCVA 594 G + E L + + D G Y CVA Sbjct: 2337 KGVEILDEGHILQLKNIHVSDTGRYVCVA 2365 Score = 168 bits (426), Expect = 1e-41 Identities = 151/576 (26%), Positives = 241/576 (41%), Gaps = 54/576 (9%) Query: 40 PPTITKQSAKDHI-VDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 98 PPTI + + + V ++ +EC+ KG P P HW ++ + + DP V + R Sbjct: 1451 PPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLG-DPNVELLDRG-- 1507 Query: 99 LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENL-DPVVVQEGAP 157 V+ ++ R + +G YQC N G + I+L + P N+ + V + Sbjct: 1508 QVLHLKNARRND--KGRYQCTVSNAAGKQAKD-IKLTIYIPPSIKGGNVTTDISVLINSL 1564 Query: 158 LTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARF 217 + L+C GLP P I W ++ + + L+ + D T Y+C+ Sbjct: 1565 IKLECE-TRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSAT-YTCH--- 1619 Query: 218 HFTHTIQQKNPFTLKVLTTRGVAERT--------PSFMYPQGTASSQMVLRGMDLLLECI 269 V G AE++ P T ++ V+ L LEC Sbjct: 1620 ---------------VANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECK 1664 Query: 270 ASGVPTPDIAWYKKGGDL-PSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMG--SIR 326 A+G P+P + W K G + +D + E K L I + E D G+Y C+A++ G I+ Sbjct: 1665 AAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIK 1724 Query: 327 HTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNR 386 + + V V A DE I+ L C G+P PT+ W+ +G+ L Sbjct: 1725 YEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQ-LIDERDGFKI 1783 Query: 387 EVAGDTIIFRDTQISSRAVYQC---NTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVI 443 + G ++ Q+S+ +Y+C NT+ +H F + VPP + S V+ Sbjct: 1784 LLNGRKLVIAQAQVSNTGLYRCMAANTAGDH----KKEFEVTVHVPPTIKSSGLSERVVV 1839 Query: 444 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGS-LEIKMIRKEDQGIYTCV 502 Y L C G P P++ W K+ Q N GN + +G L+I ED G YTCV Sbjct: 1840 KYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCV 1899 Query: 503 ATNILGKAENQVRLEVKDPTRIYRMPE--DQVARRGTTVQLECRVKHDPSLKLTVSWLKD 560 ATN G+ + ++L V +P + + ++ VQLEC+ +P +T W KD Sbjct: 1900 ATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVIT--WYKD 1957 Query: 561 DEPLYIGNRMK--KEDDSLTIFGVAERDQGSYTCVA 594 + L M + I D G Y CVA Sbjct: 1958 NRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVA 1993 Score = 162 bits (410), Expect = 9e-40 Identities = 154/587 (26%), Positives = 244/587 (41%), Gaps = 42/587 (7%) Query: 40 PPTITKQSAKDHI-VDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 98 PP I Q H+ V + I C A+G P P W++ + + VS GT Sbjct: 1170 PPKI--QRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVS--NPDGT 1225 Query: 99 LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP---VVVQEG 155 L ID + P + G Y C A N GT I L V + P E+L+P QE Sbjct: 1226 LSIDQAT---PSD-AGIYTCVATNIAGTD-ETEITLHVQEPPT--VEDLEPPYNTTFQER 1278 Query: 156 AP---LTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYS 212 + C P G P P I W+ + E ++ +S +G L + +Y Sbjct: 1279 VANQRIEFPC-PAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYI 1337 Query: 213 CNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASG 272 C A + T ++K + LKV P + + ++ VL L C G Sbjct: 1338 CVA-VNEAGTTERK--YNLKV--------HVPPVIKDKEQVTNVSVLLNQLTNLFCEVEG 1386 Query: 273 VPTPDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISV 331 P+P I WYK + S + N K L++ + ED+G Y C A N G+ + ++ Sbjct: 1387 TPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNI 1446 Query: 332 RVKAAPYWLDE--PKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVA 389 V P + P + + D L C+ G P P + W +G+PL PN Sbjct: 1447 DVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDR 1506 Query: 390 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQL-IRVILYNRT 448 G + ++ + + + YQC SN G + +++ +PP + I V++ + Sbjct: 1507 GQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIY-IPPSIKGGNVTTDISVLINSLI 1565 Query: 449 RLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILG 508 +L+C G P+P + W+K+GQ ++ + L I + D YTC N+ G Sbjct: 1566 KLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAG 1625 Query: 509 KAENQVRLEVKDPTRI---YRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLY 565 AE ++V P I P ++ ++ LEC+ +PS LT WLKD P+ Sbjct: 1626 TAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILT--WLKDGVPVK 1683 Query: 566 IGNRMKKE--DDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 610 + ++ E L I E D+G Y CVA++ + K + VL Sbjct: 1684 ANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVL 1730 Score = 159 bits (401), Expect = 9e-39 Identities = 148/563 (26%), Positives = 233/563 (41%), Gaps = 39/563 (6%) Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 99 PP+I + D +V +I C A G P PS HWT+N I PR R + Sbjct: 3896 PPSIADEPT-DFLVTKHAPAVITCTASGVPFPSIHWTKN----GIRLLPRGDGYRILSSG 3950 Query: 100 VIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLT 159 I+ + + G Y C ARN G+A + L V + P+ + + V+ P+ Sbjct: 3951 AIEILA--TQLNHAGRYTCVARNAAGSA-HRHVTLHVHEPPVIQPQPSELHVILNN-PIL 4006 Query: 160 LQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHF 219 L C G PSP I W + T + + +G L S + +D T Y C A Sbjct: 4007 LPCE-ATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGT-YMCVA---- 4060 Query: 220 THTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIA 279 +NP L + + P + P ++ + L C A G+P PDI Sbjct: 4061 ------QNP-AGTALGKIKLNVQVPPVISPH--LKEYVIAVDKPITLSCEADGLPPPDIT 4111 Query: 280 WYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYW 339 W+K G + + + +L+I V D+G Y C+A+N GS + + V P Sbjct: 4112 WHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRI 4171 Query: 340 LDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQ 399 + + L C A+G P P + W + L + E G+ +I + Sbjct: 4172 RSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGE-LILENVV 4230 Query: 400 ISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPI 459 + Y C +N G ++V +P P + + + + RL C G P+ Sbjct: 4231 LEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGD--VSLNKGEQLRLSCKATGIPL 4288 Query: 460 PTLRWFKNGQ--GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLE 517 P L W N ++ D N H L I+ + KED G Y C A N +G + + Sbjct: 4289 PKLTWTFNNNIIPAHFDSVNGH----SELVIERVSKEDSGTYVCTAENSVGFVKAIGFVY 4344 Query: 518 VKDPTRIYR--MPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKK-ED 574 VK+P +++ P + + G L C VK DP+ T+ W + + I +R+++ + Sbjct: 4345 VKEPP-VFKGDYPSNWIEPLGGNAILNCEVKGDPT--PTIQWNRKGVDIEISHRIRQLGN 4401 Query: 575 DSLTIFGVAERDQGSYTCVASTE 597 SL I+G D G YTCVA+ E Sbjct: 4402 GSLAIYGTVNEDAGDYTCVATNE 4424 Score = 154 bits (388), Expect = 3e-37 Identities = 146/586 (24%), Positives = 245/586 (41%), Gaps = 44/586 (7%) Query: 36 ELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR 95 ++++PP + Q + V P + ++ C + W RN R +A+ R+ R Sbjct: 515 DVSEPPPVI-QVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARI---RT 570 Query: 96 SGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSP---LWPKENLDPVVV 152 L ++ +S + GEY C ++ G++ ++ + L V + P + PK Sbjct: 571 LANLSLELKSVKFNDA--GEYHCMVSSEGGSSAAS-VFLTVQEPPKVTVMPKNQS----F 623 Query: 153 QEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYS 212 G+ +++ C+ G P P I W + M I R +G L+ N +D Y Sbjct: 624 TGGSEVSIMCSAT-GYPKPKIAWTVNDMF-IVGSHRYRMTSDGTLFIKNAAPKDAGI-YG 680 Query: 213 CNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASG 272 C A K TL+ + P M Q S +V G ++EC SG Sbjct: 681 CLAS---NSAGTDKQNSTLRYI-------EAPKLMVVQ---SELLVALGDITVMECKTSG 727 Query: 273 VPTPDIAWYKKGGDL---PSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTI 329 +P P + W+K GDL PS + L+I + D+G+Y C+A N+ G I Sbjct: 728 IPPPQVKWFK--GDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKI 785 Query: 330 SVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQW-MVNGEPLQSAPPNPN--R 386 ++ V + P ++ EP ++ + G + L C G P+PT++W ++ P+ S P + + Sbjct: 786 TLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSIS 845 Query: 387 EVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYN 446 ++ + + S + Y C N+ G + + V+V + ++ + VI Sbjct: 846 QLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQ 905 Query: 447 RTRLDCPFF-GSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATN 505 + L C G+PIP RW KN L V +GSL I+ ++ +D G YTCVA+N Sbjct: 906 QLTLPCTLLAGNPIPERRWIKN-SAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASN 964 Query: 506 ILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLY 565 + G + V I + G V L C+ +P K +V W K E + Sbjct: 965 VAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNP--KPSVIWSKKGELIS 1022 Query: 566 IGNR--MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609 + D SL + + G Y C A+ K LTV Sbjct: 1023 TSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTV 1068 Score = 153 bits (386), Expect = 5e-37 Identities = 144/585 (24%), Positives = 238/585 (40%), Gaps = 37/585 (6%) Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 99 PP++ +++ V + I + CE G P P W +N + + + + R+ + Sbjct: 2963 PPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQI 3022 Query: 100 VIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPL---WPKENLDPVVVQEGA 156 + S G GEY C A N+ G + + L V P E+L V V+EG Sbjct: 3023 IRAKVSDG------GEYTCIAINQAGES-KKKFSLTVYVPPSIKDHDSESLSVVNVREGT 3075 Query: 157 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 216 ++L+C +P PVI W + IT+ V +G + Y C A Sbjct: 3076 SVSLECESN-AVPPPVITWYKNG-RMITESTHVEILADGQMLHIKKAEVSDTGQYVCRA- 3132 Query: 217 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 276 + F L V PS P+ + + + L C A+G+P P Sbjct: 3133 --INVAGRDDKNFHLNVYVP-------PSIEGPEREVIVETISN--PVTLTCDATGIPPP 3181 Query: 277 DIAW---YKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIR--HTISV 331 IAW +K+ + S + + + L+I DSG Y C+ASN G + + +S+ Sbjct: 3182 TIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSI 3241 Query: 332 RVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVA-G 390 +V + + P ++ + GE+ LVC ANG P P +QW+ +G+P+ S R A G Sbjct: 3242 QVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANG 3301 Query: 391 DTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPP-RMLSPRNQLIRVILYNRTR 449 T+ S Y C +N G ++V P R + + ++ Sbjct: 3302 STLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSIN 3361 Query: 450 LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGK 509 ++C G+P P + W KNG L + + I + D +YTCVA+N G Sbjct: 3362 IECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGV 3421 Query: 510 AENQVRLEVKDPTRIYRM--PEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIG 567 L+V P + E+ +G++ + C P+ +++WL+D +PL + Sbjct: 3422 DNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPA--PSMAWLRDGQPLGLD 3479 Query: 568 NRMKKEDDS--LTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 610 + L + D G YTC+AS E + L VL Sbjct: 3480 AHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVL 3524 Score = 152 bits (385), Expect = 7e-37 Identities = 156/588 (26%), Positives = 238/588 (40%), Gaps = 46/588 (7%) Query: 40 PPTITKQSAKDHIVDPRDN-ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 98 PP+I + ++ IV+ N + + C+A G P P+ W +N + I + +R SG Sbjct: 3150 PPSI-EGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHK--RIENSDSLEVRILSGG 3206 Query: 99 LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNR-IRLQVSKSPLWPKENLDPVVVQEGAP 157 + + G Y C A N G A + +QV S + D V V G Sbjct: 3207 SKLQIARSQHSDS--GNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSD-VSVLLGEN 3263 Query: 158 LTLQCNPPPGLPSPVIFWMSSSMEPIT--QDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA 215 + L CN G+P+P+I W+ +PI + +R+ NG L Y+C A Sbjct: 3264 VELVCNAN-GIPTPLIQWLKDG-KPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVA 3321 Query: 216 RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 275 ++ F L V T P+ + A M L + +EC A+G P Sbjct: 3322 T---NPAGEEDRIFNLNVYVT-------PTIRGNKDEAEKLMTLVDTSINIECRATGTPP 3371 Query: 276 PDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVK 334 P I W K G LP S + + +RI D Y C+ASN+ G +++V Sbjct: 3372 PQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVF 3431 Query: 335 AAPYWLDE--PKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT 392 A P + + + + G + C +G P P++ W+ +G+PL + G Sbjct: 3432 APPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPL-GLDAHLTVSTHGMV 3490 Query: 393 IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDC 452 + + Y C SNE G + + + VL+ P S ++ I VI+ N L C Sbjct: 3491 LQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTC 3550 Query: 453 PFFGSPIPTLRWFKNG-------QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATN 505 G P P + W K+G Q L GG L I + ED G YTC+A++ Sbjct: 3551 IASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEV-------LRISTAQVEDTGRYTCLASS 3603 Query: 506 ILGKAENQVRLEVKDPTRIYRM--PEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEP 563 G + + + V P I P D R V LEC K D ++WL++ E Sbjct: 3604 PAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLEC--KSDAVPPPVITWLRNGER 3661 Query: 564 LYIGNRMK--KEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609 L R++ L I D +YTCVAS + + LTV Sbjct: 3662 LQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTV 3709 Score = 152 bits (384), Expect = 9e-37 Identities = 153/576 (26%), Positives = 231/576 (40%), Gaps = 35/576 (6%) Query: 40 PPTIT-KQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 98 PP I +D V + +EC++ P P W RN + PRV + Sbjct: 3619 PPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGE--RLQATPRVRILSGGRY 3676 Query: 99 LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPL 158 L I+ G Y C A N G I L V+ P K +V+ Sbjct: 3677 LQINNADLGDT----ANYTCVASNIAGKTTREFI-LTVNVPPNI-KGGPQSLVILLNKST 3730 Query: 159 TLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFH 218 L+C G+P+P I W R S NG L+ + + D Y C A + Sbjct: 3731 VLECIAE-GVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGR-YLCMAT-N 3787 Query: 219 FTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDI 278 T +++ + V P + P T + V+ + L C A+G+P P I Sbjct: 3788 AAGTDRRRIDLQVHV----------PPSIAPGPT--NMTVIVNVQTTLACEATGIPKPSI 3835 Query: 279 AWYKKGGDLPSDKAKFEN---FNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 335 W K G L D+ + + +L I + S +D+ Y C +N G + T+ + V+ Sbjct: 3836 NWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQV 3895 Query: 336 APYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPN-REVAGDTII 394 P DEP + ++ + C A+G P P++ W NG ++ P R ++ I Sbjct: 3896 PPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNG--IRLLPRGDGYRILSSGAIE 3953 Query: 395 FRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPF 454 TQ++ Y C N G A+ V++ P ++ P+ + VIL N L C Sbjct: 3954 ILATQLNHAGRYTCVARNAAGS--AHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEA 4011 Query: 455 FGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQV 514 G+P P + W K G N G N+ V +G L+I +ED G Y CVA N G A ++ Sbjct: 4012 TGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKI 4071 Query: 515 RLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK-KE 573 +L V+ P I ++ V + L C P +T W KD + R + Sbjct: 4072 KLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDIT--WHKDGRAIVESIRQRVLS 4129 Query: 574 DDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609 SL I V D G YTC+A+ LTV Sbjct: 4130 SGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTV 4165 Score = 149 bits (377), Expect = 6e-36 Identities = 163/614 (26%), Positives = 250/614 (40%), Gaps = 81/614 (13%) Query: 41 PTITKQSAK--DHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 98 PTIT + + IV +I +ECE +G P P+ W ++ AK + Sbjct: 2290 PTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGH--- 2346 Query: 99 LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP--VVVQEGA 156 ++ ++ + G Y C A N G + L V P + P + V E Sbjct: 2347 -ILQLKNIHVSDT--GRYVCVAVNVAGMT-DKKYDLSVHAPPSIIGNHRSPENISVVEKN 2402 Query: 157 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQT------D 210 ++L C G+P P I W VS ++ + ML+ MQT Sbjct: 2403 SVSLTCEAS-GIPLPSITWFKDGWP-------VSLSNSVRILSGGRMLRLMQTTMEDAGQ 2454 Query: 211 YSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIA 270 Y+C R +++ F L VL P + + T V + L C Sbjct: 2455 YTCVVR---NAAGEERKIFGLSVLV--------PPHIVGENTLEDVKVKEKQSVTLTCEV 2503 Query: 271 SGVPTPDIAWYKKGGDLPSDKAK-FENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTI 329 +G P P+I W+K G L D+A + + L+ITNV +G Y CLAS+ G + Sbjct: 2504 TGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSF 2563 Query: 330 SVRVKAAPYWLD-----EPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNP 384 S+ V +P P+++ + LVC A P T+ W +G PL+S Sbjct: 2564 SLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLES----- 2618 Query: 385 NREV----AGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRM-------- 432 NR + G T+ + Q + Y C +NE G ++ + V V +PP + Sbjct: 2619 NRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVY-IPPIINKGDLWGP 2677 Query: 433 -LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENG-SLEIKM 490 LSP+ I+V N L+C + P +L W+K+GQ D + ++ NG +L+IK Sbjct: 2678 GLSPKEVKIKV--NNTLTLECEAYAIPSASLSWYKDGQPLKSDD-HVNIAANGHTLQIKE 2734 Query: 491 IRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPED----QVARRG--------TT 538 + D G YTCVA+NI G+ E + ++ P ++ E R G Sbjct: 2735 AQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNP 2794 Query: 539 VQLECRVKHDPSLKLTVSWLKDDEPLYIGNR--MKKEDDSLTIFGVAERDQGSYTCVAST 596 + L C P LT W KD PL ++ + L I D G YTCVA Sbjct: 2795 ISLYCETNAAPPPTLT--WYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVN 2852 Query: 597 ELDQDLAKAYLTVL 610 E +D + + VL Sbjct: 2853 EAGEDSLQYDVRVL 2866 Score = 138 bits (347), Expect = 2e-32 Identities = 144/577 (24%), Positives = 233/577 (40%), Gaps = 56/577 (9%) Query: 63 CEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARN 122 CEA P + W ++ ++ R+ R+ ++ E+ G Y C A N Sbjct: 2597 CEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQIL------NAQEDNAGRYSCVATN 2650 Query: 123 KFGTALSNR-----IRLQVSKSPLW-----PKENLDPVVVQEGAPLTLQCNPPPGLPSPV 172 + G + + I ++K LW PKE V ++ LTL+C +PS Sbjct: 2651 EAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKE----VKIKVNNTLTLECEAY-AIPSAS 2705 Query: 173 IFWMSSSMEPITQDKRVSQGHNGD-LYFSNVMLQDMQTDYSCNA-------RFHFTHTIQ 224 + W +P+ D V+ NG L + D Y+C A F IQ Sbjct: 2706 LSWYKDG-QPLKSDDHVNIAANGHTLQIKEAQISDTGR-YTCVASNIAGEDELDFDVNIQ 2763 Query: 225 QKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKG 284 P + + L G + + ++ V+ + L C + P P + WYK G Sbjct: 2764 V--PPSFQKLWEIG------NMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDG 2815 Query: 285 GDLPS-DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWL--- 340 L S DK + L+I ED+G Y C+A N+ G VRV P Sbjct: 2816 HPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGAN 2875 Query: 341 -DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTII-FRDT 398 D P+ + + + + C ++G+P P W +G+PL + ++ ++ I+ +T Sbjct: 2876 SDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLE--DDHHKFLSNGRILQILNT 2933 Query: 399 QISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSP 458 QI+ Y C N G ++V VPP ++ P+++ + V++ N L C G P Sbjct: 2934 QITDIGRYVCVAENTAGSAKKYFNLNV-HVPPSVIGPKSENLTVVVNNFISLTCEVSGFP 2992 Query: 459 IPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEV 518 P L W KN Q L+ V +L+I + D G YTC+A N G+++ + L V Sbjct: 2993 PPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTV 3052 Query: 519 KDPTRIYRMPEDQVA----RRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK--K 572 P I + ++ R GT+V LEC P +T W K+ + ++ Sbjct: 3053 YVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVIT--WYKNGRMITESTHVEILA 3110 Query: 573 EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609 + L I D G Y C A +D +L V Sbjct: 3111 DGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNV 3147 Score = 137 bits (345), Expect = 3e-32 Identities = 141/543 (25%), Positives = 212/543 (39%), Gaps = 33/543 (6%) Query: 63 CEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARN 122 CE +G P+P W +++ + + + +G ++ FR+ PE+ G Y C A N Sbjct: 1382 CEVEGTPSPIIMWYKDN--VQVTESSTIQTVN-NGKILKLFRA--TPED-AGRYSCKAIN 1435 Query: 123 KFGTALSNRIRLQVSKSPLWPKENL-DPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSME 181 GT+ + V P N + V V + L+C G P P I W Sbjct: 1436 IAGTS-QKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVK-GTPFPDIHWFKDGKP 1493 Query: 182 PITQDKRVSQGHNGD-LYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA 240 D V G L+ N D + Y C +Q L + Sbjct: 1494 LFLGDPNVELLDRGQVLHLKNARRND-KGRYQCTVS---NAAGKQAKDIKLTIYIP---- 1545 Query: 241 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDL-PSDKAKFENFNK 299 PS T +++ + + LEC G+P P I WYK G + S +A + + + Sbjct: 1546 ---PSIKGGNVTTDISVLINSL-IKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQ 1601 Query: 300 ALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYW---LDEPKNLILAPGEDGRL 356 L I DS Y C +N G+ + V V P L P N + L Sbjct: 1602 YLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTL 1661 Query: 357 VCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGY 416 C+A GNP P + W+ +G P++ A N E G + Q R Y C ++ G Sbjct: 1662 ECKAAGNPSPILTWLKDGVPVK-ANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGE 1720 Query: 417 LLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGG 476 V VL P V++ N LDC GSP PT+ W K+GQ + G Sbjct: 1721 KEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDG 1780 Query: 477 NYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP-EDQVARR 535 + L I + + G+Y C+A N G + + + V P I ++V + Sbjct: 1781 FKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVK 1840 Query: 536 GTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAE---RDQGSYTC 592 V L+C P+ +T WLKDD+P+ K S + +A+ D G YTC Sbjct: 1841 YKPVALQCIANGIPNPSIT--WLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTC 1898 Query: 593 VAS 595 VA+ Sbjct: 1899 VAT 1901 Score = 129 bits (325), Expect = 6e-30 Identities = 150/599 (25%), Positives = 236/599 (39%), Gaps = 47/599 (7%) Query: 37 LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96 L P + + + +D V + ++ + CE GNP P W ++ + + + S Sbjct: 2475 LVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHII----S 2530 Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSP----LWPKENLDPVVV 152 G + + P + G Y C A + G S L V SP + N + V V Sbjct: 2531 GGRFLQITNVQVP--HTGRYTCLASSPAGHK-SRSFSLNVFVSPTIAGVGSDGNPEDVTV 2587 Query: 153 QEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYS 212 +P +L C P+ + ++ + ++ R+ G L N +D YS Sbjct: 2588 ILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPG-GRTLQILNAQ-EDNAGRYS 2645 Query: 213 CNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLR-GMDLLLECIAS 271 C A I+ + +KV + ++ G + ++ ++ L LEC A Sbjct: 2646 CVATNEAGEMIKH---YEVKVYIPPII---NKGDLWGPGLSPKEVKIKVNNTLTLECEAY 2699 Query: 272 GVPTPDIAWYKKGGDLPS-DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTIS 330 +P+ ++WYK G L S D L+I D+G Y C+ASN G Sbjct: 2700 AIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFD 2759 Query: 331 VRVKAAPYW--LDEPKNLILAPGEDGR-----------LVCRANGNPKPTVQWMVNGEPL 377 V ++ P + L E N+ L G +G L C N P PT+ W +G PL Sbjct: 2760 VNIQVPPSFQKLWEIGNM-LDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPL 2818 Query: 378 QSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRN 437 S+ G + ++ Y C NE G V VL VPP + + Sbjct: 2819 TSS-DKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVL-VPPIIKGANS 2876 Query: 438 QL---IRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGS-LEIKMIRK 493 L + V++ ++C GSP P W K+GQ L+ ++ NG L+I + Sbjct: 2877 DLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQ-PLLEDDHHKFLSNGRILQILNTQI 2935 Query: 494 EDQGIYTCVATNILGKAENQVRLEVK-DPTRIYRMPEDQVARRGTTVQLECRVKHDPSLK 552 D G Y CVA N G A+ L V P+ I E+ + L C V P Sbjct: 2936 TDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPD 2995 Query: 553 LTVSWLKDDEPLYIGNR--MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609 L SWLK+++P+ + + +L I D G YTC+A + + K LTV Sbjct: 2996 L--SWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTV 3052 Score = 124 bits (312), Expect = 2e-28 Identities = 101/403 (25%), Positives = 174/403 (43%), Gaps = 22/403 (5%) Query: 219 FTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDI 278 F I + T + T V+E P P V G +L C+ ++ Sbjct: 496 FYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVT----VTPGERAVLTCLIISAVDYNL 551 Query: 279 AWYKKGGDLP-SDKAKFENF-NKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAA 336 W + D+ ++ A+ N +L + +V D+GEY C+ S++ GS ++ + V+ Sbjct: 552 TWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEP 611 Query: 337 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFR 396 P PKN G + ++C A G PKP + W VN + + + R + T+ + Sbjct: 612 PKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGS--HRYRMTSDGTLFIK 669 Query: 397 DTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFG 456 + +Y C SN G N+ + ++ P M+ L V L + T ++C G Sbjct: 670 NAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELL--VALGDITVMECKTSG 727 Query: 457 SPIPTLRWFKNGQGSNLDGGNYHVYEN--GSLEIKMIRKEDQGIYTCVATNILGKAENQV 514 P P ++WFK L + + + G L+I+ + D G YTCVA N G+A ++ Sbjct: 728 IPPPQVKWFKGDL--ELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKI 785 Query: 515 RLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDE------PLYIGN 568 L+V P + P D G+ V L C V+ P + T+ W + D P + + Sbjct: 786 TLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYP--EPTIKWRRLDNMPIFSRPFSVSS 843 Query: 569 RMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLG 611 + +L I + D+G+Y C A + + ++ +TV G Sbjct: 844 ISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTG 886 Score = 101 bits (251), Expect = 2e-21 Identities = 85/337 (25%), Positives = 139/337 (41%), Gaps = 13/337 (3%) Query: 278 IAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAP 337 +++ + G L D+ E+ + L I V+ D G Y C+A + G+ R V P Sbjct: 461 LSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPP 520 Query: 338 YWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRD 397 + P N+ + PGE L C + W N ++ A P R +A ++ + Sbjct: 521 PVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKS 580 Query: 398 TQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGS 457 + + Y C S+E G A+ F++V + P + P+NQ + + C G Sbjct: 581 VKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTG--GSEVSIMCSATGY 638 Query: 458 PIPTLRWFKNGQ---GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQV 514 P P + W N GS+ Y + +G+L IK +D GIY C+A+N G + Sbjct: 639 PKPKIAWTVNDMFIVGSH----RYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNS 694 Query: 515 RLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKED 574 L + ++ + + + G +EC+ P + V W K D L + + Sbjct: 695 TLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQ--VKWFKGDLELRPSTFLIIDP 752 Query: 575 --DSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609 L I + D G YTCVA E + K L V Sbjct: 753 LLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDV 789 >gi|19743806 roundabout 1 isoform b [Homo sapiens] Length = 1612 Score = 176 bits (446), Expect = 6e-44 Identities = 141/497 (28%), Positives = 222/497 (44%), Gaps = 35/497 (7%) Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR--SG 97 PP I + + D IV + + C+A+G P P+ W + KD S R SG Sbjct: 28 PPRIVEHPS-DLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86 Query: 98 TLV-IDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 156 +L + G + EG Y C ARN G A+S+ L+V+ ++N V+V G Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146 Query: 157 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 216 P ++C PP G P P I W +D+R++ G L + D Y C Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSD-AGKYVCVG- 203 Query: 217 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 276 T+ + ++ ++ V ER PSF+ S+ V +C A G P P Sbjct: 204 ---TNMVGERESEVAELT----VLER-PSFV---KRPSNLAVTVDDSAEFKCEARGDPVP 252 Query: 277 DIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAA 336 + W K G+LP + + + + L+I V+ D G Y C+A N +G + ++ V+ Sbjct: 253 TVRWRKDDGELPKSRYEIRD-DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEP 311 Query: 337 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEP---LQSAPPNPNREVA---- 389 P+++ +P++ ++A G C A GNP+P + W G PP + + Sbjct: 312 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 371 Query: 390 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDV----PPRML--SPRNQLIRVI 443 GD I + Q S Y C T N G ++ A++ V DV PP ++ P NQ + V Sbjct: 372 GDLTI-TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV- 429 Query: 444 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 503 L C GSP+PT+ W K+G + ENG L+I+ + D G YTC+A Sbjct: 430 -DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIA 488 Query: 504 TNILGKAENQVRLEVKD 520 + G+A +EV++ Sbjct: 489 STPSGEATWSAYIEVQE 505 Score = 144 bits (362), Expect = 3e-34 Identities = 110/379 (29%), Positives = 170/379 (44%), Gaps = 31/379 (8%) Query: 254 SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKAL--------RITN 305 S +V +G L C A G PTP I WYK G + +DK + L RI + Sbjct: 36 SDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVH 95 Query: 306 --VSEEDSGEYFCLASNKMG-SIRHTISVRVKAA-PYWLDEPKNLILAPGEDGRLVCRA- 360 S D G Y C+A N +G ++ H S+ V + P ++++A GE + C+ Sbjct: 96 GRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPP 155 Query: 361 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 420 G+P+PT+ W +G PL + + G ++ T+ S Y C +N G + Sbjct: 156 RGHPEPTISWKKDGSPLDDK--DERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESE 213 Query: 421 -AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYH 479 A ++VL+ P + P N + V + + C G P+PT+RW K+ L Y Sbjct: 214 VAELTVLERPSFVKRPSN--LAVTVDDSAEFKCEARGDPVPTVRWRKDD--GELPKSRYE 269 Query: 480 VYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTV 539 + ++ +L+I+ + D G YTCVA N++GKAE L V++P P DQV G TV Sbjct: 270 IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTV 329 Query: 540 QLECRVKHDPSLKLTVSWLKDD--------EPLYIGNRMK-KEDDSLTIFGVAERDQGSY 590 +C +P + + W ++ +P +R + LTI V D G Y Sbjct: 330 TFQCEATGNP--QPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYY 387 Query: 591 TCVASTELDQDLAKAYLTV 609 C + KAYL V Sbjct: 388 ICQTLNVAGSIITKAYLEV 406 Score = 142 bits (359), Expect = 7e-34 Identities = 134/504 (26%), Positives = 206/504 (40%), Gaps = 48/504 (9%) Query: 133 RLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQG 192 RL+ P E+ ++V +G P TL C G P+P I W E + DK + Sbjct: 21 RLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAE-GRPTPTIEWYKGG-ERVETDKDDPRS 78 Query: 193 H-----NGDLYFSNVM----LQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERT 243 H +G L+F ++ + + Y C AR + + +L+V R + Sbjct: 79 HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNA--SLEVAILRDDFRQN 136 Query: 244 PSFMYPQGTASSQMVLRGMDLLLECIAS-GVPTPDIAWYKKGGDLPSDKAKFENFNKALR 302 PS + MV G ++EC G P P I+W K G L + L Sbjct: 137 PSDV---------MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLM 187 Query: 303 ITNVSEEDSGEYFCLASNKMGSIRHTIS-VRVKAAPYWLDEPKNLILAPGEDGRLVCRAN 361 IT + D+G+Y C+ +N +G ++ + V P ++ P NL + + C A Sbjct: 188 ITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEAR 247 Query: 362 GNPKPTVQWMVNGEPLQSAPPNPNREVAGD-TIIFRDTQISSRAVYQCNTSNEHGYLLAN 420 G+P PTV+W + L P E+ D T+ R Y C N G A+ Sbjct: 248 GDPVPTVRWRKDDGEL----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEAS 303 Query: 421 AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL------- 473 A ++V + P ++ PR+Q+ V L C G+P P + W + G + L Sbjct: 304 ATLTVQEPPHFVVKPRDQV--VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQ 361 Query: 474 DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKD------PTRIYRM 527 + V + G L I +++ D G Y C N+ G + LEV D P I + Sbjct: 362 SSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG 421 Query: 528 PEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYI-GNRMKK-EDDSLTIFGVAER 585 P +Q T L C P T+ W KD + +R+K+ E+ L I Sbjct: 422 PVNQTVAVDGTFVLSCVATGSPVP--TILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 479 Query: 586 DQGSYTCVASTELDQDLAKAYLTV 609 D G YTC+AST + AY+ V Sbjct: 480 DTGRYTCIASTPSGEATWSAYIEV 503 Score = 38.1 bits (87), Expect = 0.024 Identities = 29/115 (25%), Positives = 49/115 (42%), Gaps = 7/115 (6%) Query: 39 QPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 98 +PP + +Q + V ++ C A G+P P+ W ++ + +D R+ + +G Sbjct: 413 RPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVS-TQDSRIK-QLENGV 470 Query: 99 LVIDFRSGGRPEEYEGEYQCFARNKFGTAL-SNRIRLQVSKSPLWPKENLDPVVV 152 L I + G G Y C A G A S I +Q P+ P DP ++ Sbjct: 471 LQIRYAKLGD----TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLI 521 >gi|4506569 roundabout 1 isoform a [Homo sapiens] Length = 1651 Score = 176 bits (446), Expect = 6e-44 Identities = 141/497 (28%), Positives = 222/497 (44%), Gaps = 35/497 (7%) Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR--SG 97 PP I + + D IV + + C+A+G P P+ W + KD S R SG Sbjct: 67 PPRIVEHPS-DLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 125 Query: 98 TLV-IDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 156 +L + G + EG Y C ARN G A+S+ L+V+ ++N V+V G Sbjct: 126 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 185 Query: 157 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 216 P ++C PP G P P I W +D+R++ G L + D Y C Sbjct: 186 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSD-AGKYVCVG- 242 Query: 217 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 276 T+ + ++ ++ V ER PSF+ S+ V +C A G P P Sbjct: 243 ---TNMVGERESEVAELT----VLER-PSFV---KRPSNLAVTVDDSAEFKCEARGDPVP 291 Query: 277 DIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAA 336 + W K G+LP + + + + L+I V+ D G Y C+A N +G + ++ V+ Sbjct: 292 TVRWRKDDGELPKSRYEIRD-DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEP 350 Query: 337 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEP---LQSAPPNPNREVA---- 389 P+++ +P++ ++A G C A GNP+P + W G PP + + Sbjct: 351 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 410 Query: 390 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDV----PPRML--SPRNQLIRVI 443 GD I + Q S Y C T N G ++ A++ V DV PP ++ P NQ + V Sbjct: 411 GDLTI-TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV- 468 Query: 444 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 503 L C GSP+PT+ W K+G + ENG L+I+ + D G YTC+A Sbjct: 469 -DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIA 527 Query: 504 TNILGKAENQVRLEVKD 520 + G+A +EV++ Sbjct: 528 STPSGEATWSAYIEVQE 544 Score = 144 bits (362), Expect = 3e-34 Identities = 110/379 (29%), Positives = 170/379 (44%), Gaps = 31/379 (8%) Query: 254 SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKAL--------RITN 305 S +V +G L C A G PTP I WYK G + +DK + L RI + Sbjct: 75 SDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVH 134 Query: 306 --VSEEDSGEYFCLASNKMG-SIRHTISVRVKAA-PYWLDEPKNLILAPGEDGRLVCRA- 360 S D G Y C+A N +G ++ H S+ V + P ++++A GE + C+ Sbjct: 135 GRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPP 194 Query: 361 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 420 G+P+PT+ W +G PL + + G ++ T+ S Y C +N G + Sbjct: 195 RGHPEPTISWKKDGSPLDDK--DERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESE 252 Query: 421 -AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYH 479 A ++VL+ P + P N + V + + C G P+PT+RW K+ L Y Sbjct: 253 VAELTVLERPSFVKRPSN--LAVTVDDSAEFKCEARGDPVPTVRWRKDD--GELPKSRYE 308 Query: 480 VYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTV 539 + ++ +L+I+ + D G YTCVA N++GKAE L V++P P DQV G TV Sbjct: 309 IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTV 368 Query: 540 QLECRVKHDPSLKLTVSWLKDD--------EPLYIGNRMK-KEDDSLTIFGVAERDQGSY 590 +C +P + + W ++ +P +R + LTI V D G Y Sbjct: 369 TFQCEATGNP--QPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYY 426 Query: 591 TCVASTELDQDLAKAYLTV 609 C + KAYL V Sbjct: 427 ICQTLNVAGSIITKAYLEV 445 Score = 142 bits (359), Expect = 7e-34 Identities = 134/504 (26%), Positives = 206/504 (40%), Gaps = 48/504 (9%) Query: 133 RLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQG 192 RL+ P E+ ++V +G P TL C G P+P I W E + DK + Sbjct: 60 RLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAE-GRPTPTIEWYKGG-ERVETDKDDPRS 117 Query: 193 H-----NGDLYFSNVM----LQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERT 243 H +G L+F ++ + + Y C AR + + +L+V R + Sbjct: 118 HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNA--SLEVAILRDDFRQN 175 Query: 244 PSFMYPQGTASSQMVLRGMDLLLECIAS-GVPTPDIAWYKKGGDLPSDKAKFENFNKALR 302 PS + MV G ++EC G P P I+W K G L + L Sbjct: 176 PSDV---------MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLM 226 Query: 303 ITNVSEEDSGEYFCLASNKMGSIRHTIS-VRVKAAPYWLDEPKNLILAPGEDGRLVCRAN 361 IT + D+G+Y C+ +N +G ++ + V P ++ P NL + + C A Sbjct: 227 ITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEAR 286 Query: 362 GNPKPTVQWMVNGEPLQSAPPNPNREVAGD-TIIFRDTQISSRAVYQCNTSNEHGYLLAN 420 G+P PTV+W + L P E+ D T+ R Y C N G A+ Sbjct: 287 GDPVPTVRWRKDDGEL----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEAS 342 Query: 421 AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL------- 473 A ++V + P ++ PR+Q+ V L C G+P P + W + G + L Sbjct: 343 ATLTVQEPPHFVVKPRDQV--VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQ 400 Query: 474 DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKD------PTRIYRM 527 + V + G L I +++ D G Y C N+ G + LEV D P I + Sbjct: 401 SSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG 460 Query: 528 PEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYI-GNRMKK-EDDSLTIFGVAER 585 P +Q T L C P T+ W KD + +R+K+ E+ L I Sbjct: 461 PVNQTVAVDGTFVLSCVATGSPVP--TILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 518 Query: 586 DQGSYTCVASTELDQDLAKAYLTV 609 D G YTC+AST + AY+ V Sbjct: 519 DTGRYTCIASTPSGEATWSAYIEV 542 Score = 38.1 bits (87), Expect = 0.024 Identities = 29/115 (25%), Positives = 49/115 (42%), Gaps = 7/115 (6%) Query: 39 QPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 98 +PP + +Q + V ++ C A G+P P+ W ++ + +D R+ + +G Sbjct: 452 RPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVS-TQDSRIK-QLENGV 509 Query: 99 LVIDFRSGGRPEEYEGEYQCFARNKFGTAL-SNRIRLQVSKSPLWPKENLDPVVV 152 L I + G G Y C A G A S I +Q P+ P DP ++ Sbjct: 510 LQIRYAKLGD----TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLI 560 >gi|224994173 roundabout 1 isoform d [Homo sapiens] Length = 1551 Score = 171 bits (434), Expect = 1e-42 Identities = 141/500 (28%), Positives = 222/500 (44%), Gaps = 38/500 (7%) Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR--SG 97 PP I + + D IV + + C+A+G P P+ W + KD S R SG Sbjct: 28 PPRIVEHPS-DLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86 Query: 98 TLV-IDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 156 +L + G + EG Y C ARN G A+S+ L+V+ ++N V+V G Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146 Query: 157 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 216 P ++C PP G P P I W +D+R++ G L + D Y C Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSD-AGKYVCVG- 203 Query: 217 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 276 T+ + ++ ++ V ER PSF+ S+ V +C A G P P Sbjct: 204 ---TNMVGERESEVAELT----VLER-PSFV---KRPSNLAVTVDDSAEFKCEARGDPVP 252 Query: 277 DIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAA 336 + W K G+LP + + + + L+I V+ D G Y C+A N +G + ++ V+ Sbjct: 253 TVRWRKDDGELPKSRYEIRD-DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVG 311 Query: 337 ---PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEP---LQSAPPNPNREVA- 389 P+++ +P++ ++A G C A GNP+P + W G PP + + Sbjct: 312 SEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSV 371 Query: 390 ---GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDV----PPRML--SPRNQLI 440 GD I + Q S Y C T N G ++ A++ V DV PP ++ P NQ + Sbjct: 372 SQTGDLTI-TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV 430 Query: 441 RVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYT 500 V L C GSP+PT+ W K+G + ENG L+I+ + D G YT Sbjct: 431 AV--DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT 488 Query: 501 CVATNILGKAENQVRLEVKD 520 C+A+ G+A +EV++ Sbjct: 489 CIASTPSGEATWSAYIEVQE 508 Score = 137 bits (345), Expect = 3e-32 Identities = 134/507 (26%), Positives = 206/507 (40%), Gaps = 51/507 (10%) Query: 133 RLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQG 192 RL+ P E+ ++V +G P TL C G P+P I W E + DK + Sbjct: 21 RLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAE-GRPTPTIEWYKGG-ERVETDKDDPRS 78 Query: 193 H-----NGDLYFSNVM----LQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERT 243 H +G L+F ++ + + Y C AR + + +L+V R + Sbjct: 79 HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNA--SLEVAILRDDFRQN 136 Query: 244 PSFMYPQGTASSQMVLRGMDLLLECIAS-GVPTPDIAWYKKGGDLPSDKAKFENFNKALR 302 PS + MV G ++EC G P P I+W K G L + L Sbjct: 137 PSDV---------MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLM 187 Query: 303 ITNVSEEDSGEYFCLASNKMGSIRHTIS-VRVKAAPYWLDEPKNLILAPGEDGRLVCRAN 361 IT + D+G+Y C+ +N +G ++ + V P ++ P NL + + C A Sbjct: 188 ITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEAR 247 Query: 362 GNPKPTVQWMVNGEPLQSAPPNPNREVAGD-TIIFRDTQISSRAVYQCNTSNEHGYLLAN 420 G+P PTV+W + L P E+ D T+ R Y C N G A+ Sbjct: 248 GDPVPTVRWRKDDGEL----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEAS 303 Query: 421 AFVSVL---DVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL---- 473 A ++V + P ++ PR+Q+ V L C G+P P + W + G + L Sbjct: 304 ATLTVQVGSEPPHFVVKPRDQV--VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQ 361 Query: 474 ---DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKD------PTRI 524 + V + G L I +++ D G Y C N+ G + LEV D P I Sbjct: 362 PPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVI 421 Query: 525 YRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYI-GNRMKK-EDDSLTIFGV 582 + P +Q T L C P T+ W KD + +R+K+ E+ L I Sbjct: 422 RQGPVNQTVAVDGTFVLSCVATGSPVP--TILWRKDGVLVSTQDSRIKQLENGVLQIRYA 479 Query: 583 AERDQGSYTCVASTELDQDLAKAYLTV 609 D G YTC+AST + AY+ V Sbjct: 480 KLGDTGRYTCIASTPSGEATWSAYIEV 506 Score = 38.1 bits (87), Expect = 0.024 Identities = 29/115 (25%), Positives = 49/115 (42%), Gaps = 7/115 (6%) Query: 39 QPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 98 +PP + +Q + V ++ C A G+P P+ W ++ + +D R+ + +G Sbjct: 416 RPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVS-TQDSRIK-QLENGV 473 Query: 99 LVIDFRSGGRPEEYEGEYQCFARNKFGTAL-SNRIRLQVSKSPLWPKENLDPVVV 152 L I + G G Y C A G A S I +Q P+ P DP ++ Sbjct: 474 LQIRYAKLGD----TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLI 524 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.318 0.135 0.419 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 27,100,915 Number of Sequences: 37866 Number of extensions: 1355133 Number of successful extensions: 11032 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 279 Number of HSP's successfully gapped in prelim test: 164 Number of HSP's that attempted gapping in prelim test: 3246 Number of HSP's gapped (non-prelim): 3526 length of query: 619 length of database: 18,247,518 effective HSP length: 108 effective length of query: 511 effective length of database: 14,157,990 effective search space: 7234732890 effective search space used: 7234732890 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.