Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 22749049
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22749049 Leber congenital amaurosis 5-like [Homo sapiens]
(670 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22749049 Leber congenital amaurosis 5-like [Homo sapiens] 1326 0.0
gi|170650672 Leber congenital amaurosis 5 [Homo sapiens] 204 2e-52
gi|170650670 Leber congenital amaurosis 5 [Homo sapiens] 204 2e-52
gi|71061468 centromere protein E [Homo sapiens] 68 2e-11
gi|221219020 NYD-SP11 protein [Homo sapiens] 62 2e-09
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 62 2e-09
gi|30794488 kinesin family member 27 [Homo sapiens] 62 2e-09
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 61 4e-09
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 61 4e-09
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 60 7e-09
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 60 7e-09
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 58 2e-08
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 58 3e-08
gi|4503509 eukaryotic translation initiation factor 3, subunit 1... 57 7e-08
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 57 7e-08
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 57 7e-08
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 57 7e-08
gi|28416946 myosin 18A isoform a [Homo sapiens] 57 7e-08
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 56 9e-08
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 56 1e-07
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 55 2e-07
gi|38044112 restin isoform b [Homo sapiens] 55 3e-07
gi|4506751 restin isoform a [Homo sapiens] 55 3e-07
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 55 3e-07
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 54 4e-07
gi|42794779 myosin 18A isoform b [Homo sapiens] 54 4e-07
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 54 6e-07
gi|216548091 leucine zipper protein 1 [Homo sapiens] 54 6e-07
gi|216548085 leucine zipper protein 1 [Homo sapiens] 54 6e-07
gi|156104908 myosin heavy chain 6 [Homo sapiens] 54 6e-07
>gi|22749049 Leber congenital amaurosis 5-like [Homo sapiens]
Length = 670
Score = 1327 bits (3433), Expect = 0.0
Identities = 670/670 (100%), Positives = 670/670 (100%)
Query: 1 MSLADLTKTNIDEHFFGVALENNRRSAACKRSPGTGDFSRNSNASNKSVDYSRSQCSCGS 60
MSLADLTKTNIDEHFFGVALENNRRSAACKRSPGTGDFSRNSNASNKSVDYSRSQCSCGS
Sbjct: 1 MSLADLTKTNIDEHFFGVALENNRRSAACKRSPGTGDFSRNSNASNKSVDYSRSQCSCGS 60
Query: 61 LSSQYDYSEDFLCDCSEKAINRNYLKQPVVKEKEKKKYNVSKISQSKGQKEISVEKKHTW 120
LSSQYDYSEDFLCDCSEKAINRNYLKQPVVKEKEKKKYNVSKISQSKGQKEISVEKKHTW
Sbjct: 61 LSSQYDYSEDFLCDCSEKAINRNYLKQPVVKEKEKKKYNVSKISQSKGQKEISVEKKHTW 120
Query: 121 NASLFNSQIHMIAQRRDAMAHRILSARLHKIKGLKNELADMHHKLEAILTENQFLKQLQL 180
NASLFNSQIHMIAQRRDAMAHRILSARLHKIKGLKNELADMHHKLEAILTENQFLKQLQL
Sbjct: 121 NASLFNSQIHMIAQRRDAMAHRILSARLHKIKGLKNELADMHHKLEAILTENQFLKQLQL 180
Query: 181 RHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKD 240
RHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKD
Sbjct: 181 RHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKD 240
Query: 241 ILQALQKLSEDKNLAEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIET 300
ILQALQKLSEDKNLAEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIET
Sbjct: 241 ILQALQKLSEDKNLAEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIET 300
Query: 301 RKTLAAQTATKTLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSV 360
RKTLAAQTATKTLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSV
Sbjct: 301 RKTLAAQTATKTLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSV 360
Query: 361 QADRKILPFTSMRHQGTQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVNKLPKQE 420
QADRKILPFTSMRHQGTQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVNKLPKQE
Sbjct: 361 QADRKILPFTSMRHQGTQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVNKLPKQE 420
Query: 421 DSKRKYEDLSGEEKHLEVQILLENTGRQKDKKEDQEKKNIFVKEEQELPPKIIEVIHPER 480
DSKRKYEDLSGEEKHLEVQILLENTGRQKDKKEDQEKKNIFVKEEQELPPKIIEVIHPER
Sbjct: 421 DSKRKYEDLSGEEKHLEVQILLENTGRQKDKKEDQEKKNIFVKEEQELPPKIIEVIHPER 480
Query: 481 ESNQEDVLVREKFKRSMQRNGVDDTLGKGTAPYTKGPLRQRRHYSFTEATENLHHGLPAS 540
ESNQEDVLVREKFKRSMQRNGVDDTLGKGTAPYTKGPLRQRRHYSFTEATENLHHGLPAS
Sbjct: 481 ESNQEDVLVREKFKRSMQRNGVDDTLGKGTAPYTKGPLRQRRHYSFTEATENLHHGLPAS 540
Query: 541 GGPANAGNMRYSHSTGKHLSNREEMELEHSDSGYEPSFGKSSRIKVKDTTFRDKKSSLME 600
GGPANAGNMRYSHSTGKHLSNREEMELEHSDSGYEPSFGKSSRIKVKDTTFRDKKSSLME
Sbjct: 541 GGPANAGNMRYSHSTGKHLSNREEMELEHSDSGYEPSFGKSSRIKVKDTTFRDKKSSLME 600
Query: 601 ELFGSGYVLKTDQSSPGVAKGSEEPLQSKESHPLPPSQASTSHAFGDSKVTVVNSIKPSS 660
ELFGSGYVLKTDQSSPGVAKGSEEPLQSKESHPLPPSQASTSHAFGDSKVTVVNSIKPSS
Sbjct: 601 ELFGSGYVLKTDQSSPGVAKGSEEPLQSKESHPLPPSQASTSHAFGDSKVTVVNSIKPSS 660
Query: 661 PTEGKRKIII 670
PTEGKRKIII
Sbjct: 661 PTEGKRKIII 670
>gi|170650672 Leber congenital amaurosis 5 [Homo sapiens]
Length = 697
Score = 204 bits (519), Expect = 2e-52
Identities = 165/546 (30%), Positives = 278/546 (50%), Gaps = 62/546 (11%)
Query: 137 DAMAHRILSARLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNL 196
D + RILSARL KI L+NE++++ KL +L EN+ LK+LQ R KA+ K+E+++N +
Sbjct: 98 DLVTKRILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEI 157
Query: 197 PQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAE 256
Q++ +H NE+ L++ LRKSQEKER +++++T+S+L +TK LQ L+++SE ++L E
Sbjct: 158 SQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPE 217
Query: 257 REELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVE 316
R++L KL K+D +++I+ L K L L+ +F RQL E ++ A K LQ E
Sbjct: 218 RDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKE 277
Query: 317 VKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKILPFTSMRHQG 376
V+ L KLKEK+REL+IKNIYS+R+ K+ + E + + Q+D L ++
Sbjct: 278 VQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTME 337
Query: 377 TQKSDVPPLTTKGKKATGN---------IDHKEKSTEINHEIPHCVNKLPKQEDSKRKYE 427
K + PLT + N +D + + + H +N + ++E+ +
Sbjct: 338 DFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQD-RHGEAGILNPIMEREE-----K 391
Query: 428 DLSGEEKHL---EVQILLENTGRQKDKKEDQEKKNIFVKEEQ-ELPPKIIEV-IHPERES 482
++ EE H+ EV+ L + R++ K+ +EK ++ +EE+ E ++ ++P +
Sbjct: 392 FVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNM 451
Query: 483 NQEDVLVREKFKRSM---QRNGVDDTL-GKGTAPYTKGPL------------RQRRHYSF 526
++ E+ KR M + N +D L Y PL R + Y F
Sbjct: 452 DKLQGEEEERLKREMLLAKLNEIDRELQDSRNLKYPVLPLLPDFESKLHSPERSPKTYRF 511
Query: 527 TEATENLHHG--------LPASGGPANAGNMR------------YSHSTGKHLSNREEME 566
+E++E L +G G N+GN+R Y S K
Sbjct: 512 SESSERLFNGHHLQDISFSTPKGEGQNSGNVRSPASPNEFAFGSYVPSFAKTSERSNPFS 571
Query: 567 LEHSDSGYE-PSFGKSSRIKVKDTTFRDKKSSLMEELFGSG-----YVLKTDQSSPGVAK 620
+ S ++ S K S+ V T ++KK++LME+LFG+ +D +S +K
Sbjct: 572 QKSSFLDFQRNSMEKLSKDGVDLITRKEKKANLMEQLFGASGSSTISSKSSDPNSVASSK 631
Query: 621 GSEEPL 626
G +PL
Sbjct: 632 GDIDPL 637
>gi|170650670 Leber congenital amaurosis 5 [Homo sapiens]
Length = 697
Score = 204 bits (519), Expect = 2e-52
Identities = 165/546 (30%), Positives = 278/546 (50%), Gaps = 62/546 (11%)
Query: 137 DAMAHRILSARLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNL 196
D + RILSARL KI L+NE++++ KL +L EN+ LK+LQ R KA+ K+E+++N +
Sbjct: 98 DLVTKRILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEI 157
Query: 197 PQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAE 256
Q++ +H NE+ L++ LRKSQEKER +++++T+S+L +TK LQ L+++SE ++L E
Sbjct: 158 SQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPE 217
Query: 257 REELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVE 316
R++L KL K+D +++I+ L K L L+ +F RQL E ++ A K LQ E
Sbjct: 218 RDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKE 277
Query: 317 VKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKILPFTSMRHQG 376
V+ L KLKEK+REL+IKNIYS+R+ K+ + E + + Q+D L ++
Sbjct: 278 VQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTME 337
Query: 377 TQKSDVPPLTTKGKKATGN---------IDHKEKSTEINHEIPHCVNKLPKQEDSKRKYE 427
K + PLT + N +D + + + H +N + ++E+ +
Sbjct: 338 DFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQD-RHGEAGILNPIMEREE-----K 391
Query: 428 DLSGEEKHL---EVQILLENTGRQKDKKEDQEKKNIFVKEEQ-ELPPKIIEV-IHPERES 482
++ EE H+ EV+ L + R++ K+ +EK ++ +EE+ E ++ ++P +
Sbjct: 392 FVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNM 451
Query: 483 NQEDVLVREKFKRSM---QRNGVDDTL-GKGTAPYTKGPL------------RQRRHYSF 526
++ E+ KR M + N +D L Y PL R + Y F
Sbjct: 452 DKLQGEEEERLKREMLLAKLNEIDRELQDSRNLKYPVLPLLPDFESKLHSPERSPKTYRF 511
Query: 527 TEATENLHHG--------LPASGGPANAGNMR------------YSHSTGKHLSNREEME 566
+E++E L +G G N+GN+R Y S K
Sbjct: 512 SESSERLFNGHHLQDISFSTPKGEGQNSGNVRSPASPNEFAFGSYVPSFAKTSERSNPFS 571
Query: 567 LEHSDSGYE-PSFGKSSRIKVKDTTFRDKKSSLMEELFGSG-----YVLKTDQSSPGVAK 620
+ S ++ S K S+ V T ++KK++LME+LFG+ +D +S +K
Sbjct: 572 QKSSFLDFQRNSMEKLSKDGVDLITRKEKKANLMEQLFGASGSSTISSKSSDPNSVASSK 631
Query: 621 GSEEPL 626
G +PL
Sbjct: 632 GDIDPL 637
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 68.2 bits (165), Expect = 2e-11
Identities = 94/442 (21%), Positives = 198/442 (44%), Gaps = 56/442 (12%)
Query: 61 LSSQYDYSEDFLCDCSEKAINRNYLKQPV-VKEKEKKKY---NVSKISQSKGQKEISVEK 116
L+ ++ S++ + +++ N +K+ + VK + K++ ++KI +S+ ++E S+
Sbjct: 1333 LNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNM 1392
Query: 117 KHTWNASL-FNSQIHMIAQRRDAMAHRILSARLHKIKGLKNELADMHHKLEAILTENQFL 175
K N + S++ + A+ + ++ GL L + H +++++ E L
Sbjct: 1393 KEKDNETTKIVSEMEQFKPKDSALLRIEI-----EMLGLSKRLQESHDEMKSVAKEKDDL 1447
Query: 176 KQLQLRHLKAIGKYENSQ--NNLPQIMAKH---QNEVKNLRQLLRKSQEKERTLSRKLRE 230
++LQ + + E+ Q N+ +I+AKH + E+K L++ +E L L E
Sbjct: 1448 QRLQ-----EVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSE 1502
Query: 231 TDSQLLKTKDILQAL--------QKLSED------KNLAEREELTHKLSIITTKMDANDK 276
++++ + L+A+ Q++ E K ++E +E ++L A D
Sbjct: 1503 KETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDS 1562
Query: 277 KIQSLE-KQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKDRELEIKN 335
+QS+E K L L R Q I+ + + K +Q ++ + +LKE +E+ K
Sbjct: 1563 ALQSIESKMLELTNRLQESQEEIQIM--IKEKEEMKRVQEALQIERDQLKENTKEIVAKM 1620
Query: 336 IYSHRILKNLHDTEDYPKVSSTKSVQADRKILPFTSMRHQ-GTQKSDVPPLTTKGKKATG 394
S ++Y + T + K+ ++ Q TQK ++ + T+
Sbjct: 1621 KESQE--------KEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETE------ 1666
Query: 395 NIDHKEKSTEINHEIPHCVNKLPKQEDSKRKYEDLSGEEKHLEVQILLENTGRQKDKKED 454
NI + T+I HE + + K+ D R E+ E+ + L E R +K+E+
Sbjct: 1667 NI----RLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEE 1722
Query: 455 QEKKNIFVKEEQELPPKIIEVI 476
+ ++ +KE QE K+ ++
Sbjct: 1723 LKIVHMHLKEHQETIDKLRGIV 1744
Score = 53.5 bits (127), Expect = 6e-07
Identities = 86/445 (19%), Positives = 192/445 (43%), Gaps = 76/445 (17%)
Query: 83 NYLKQPVVKEKEKKKYNVSKISQSKG---QKEISVEKKHTWNASLFNSQIHMIAQRRDAM 139
N LK + +E + + ++K QK + ++KK A N+Q D
Sbjct: 981 NTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAK--NTQ----TLTADVK 1034
Query: 140 AHRILSARLHKIKGLKNELADMHHKLEAILTENQFLK-------QLQLRHLKAIGKYENS 192
+ I+ + KI L E ++ LE+++ E + LK ++ + + + + +
Sbjct: 1035 DNEIIEQQ-RKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDE 1093
Query: 193 QNNLPQIMAKHQN-------EVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQAL 245
+I+A+ +N E+ L + +EK + S++L+E QLL ++ + +
Sbjct: 1094 LKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEM 1153
Query: 246 QK----LSEDKNLAEREEL------THKLSIITTKMDANDKKIQSLEKQLRL-------- 287
QK + KN + +EL T +L + K++ N ++++S+ K+ ++
Sbjct: 1154 QKKINEIENLKNELKNKELTLEHMETERLE-LAQKLNENYEEVKSITKERKVLKELQKSF 1212
Query: 288 -----NCRAFSRQL---AIETRKTL-AAQTATKTLQVEVKHLQQKLKEK------DRELE 332
+ R + R++ ++T++ L A K Q + L++ + EK ++LE
Sbjct: 1213 ETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLE 1272
Query: 333 IKNIYSHRILKNLHDTED----YPKVSSTKSVQADRKILPFTSMRHQGTQKSDVPPLTTK 388
+ + LH+ ++ +VS T+ + ++L T++S TT
Sbjct: 1273 KSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELL---------TEQSTTKDSTTL 1323
Query: 389 GKKATGNIDHKEKSTEINHEIPHCVNKLPKQEDSKRKYEDLSGEEKHLEVQILLENTGRQ 448
+ + EK E EI L K+ D+ + ++ + E KH +++ + T +
Sbjct: 1324 ARIEMERLRLNEKFQESQEEI----KSLTKERDNLKTIKE-ALEVKHDQLKEHIRETLAK 1378
Query: 449 KDKKEDQEKKNIFVKEEQELPPKII 473
+ + ++++++ +KE+ KI+
Sbjct: 1379 IQESQSKQEQSLNMKEKDNETTKIV 1403
Score = 53.5 bits (127), Expect = 6e-07
Identities = 91/453 (20%), Positives = 194/453 (42%), Gaps = 57/453 (12%)
Query: 77 EKAINRNYLKQPVVKEKEKKKYNVSKISQSKGQKEISVEKKHTWNASLFNSQIHMIAQRR 136
E ++R + V+EK K+K S+ Q K Q+ ++V+++ S +I+ I +
Sbjct: 1112 EGELSRTCDRLAEVEEKLKEK---SQQLQEKQQQLLNVQEE----MSEMQKKINEIENLK 1164
Query: 137 DAMAHRILSARLHKIKGLK--NELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQN 194
+ + ++ L+ + + L+ +L + + ++++I E + LK+LQ
Sbjct: 1165 NELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIR 1224
Query: 195 NLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQKLSED--- 251
+ + + E+K L++ QE L R + E +Q++ T+D+ ++ KL E+
Sbjct: 1225 EIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPV 1284
Query: 252 -----------KNLAEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIET 300
K ++E +E ++L ++T + D + + RL ++ E
Sbjct: 1285 LHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEI 1344
Query: 301 RKTLAAQTATKTLQ--VEVKH-------------LQQKLKEKDRELEIKNIYSHRILKNL 345
+ + KT++ +EVKH +Q+ ++++ L +K + K +
Sbjct: 1345 KSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKE-KDNETTKIV 1403
Query: 346 HDTEDY-PKVSSTKSVQAD------RKILPFTSMRHQGTQKSDVPPL-------TTKGKK 391
+ E + PK S+ ++ + R M+ +K D+ L + + K+
Sbjct: 1404 SEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKE 1463
Query: 392 ATGNIDHKEKSTEINHEIPHCVNKLPKQEDSKRKYEDLSGEEKHLEVQILLENTGRQKDK 451
I K TE ++ HC L +QE++ + ++ EK E+ + + DK
Sbjct: 1464 NIKEIVAKHLETEEELKVAHCC--LKEQEETINELR-VNLSEKETEISTIQKQLEAINDK 1520
Query: 452 KEDQEKKNIFVKEEQELPPKIIEVIHPERESNQ 484
+++ ++ I+ KEEQ +I EV E Q
Sbjct: 1521 LQNKIQE-IYEKEEQFNIKQISEVQEKVNELKQ 1552
Score = 42.0 bits (97), Expect = 0.002
Identities = 87/435 (20%), Positives = 184/435 (42%), Gaps = 74/435 (17%)
Query: 105 QSKGQKEISVEKKHTWNASLFNSQIHMIAQRRDAMAHRILSARLHKIKGLKNELADMHHK 164
++K + ++ +EK+ S FN +I + D + L L L+ ++ D+ +
Sbjct: 677 EAKKKMQVDLEKELQ---SAFN-EITKLTSLIDGKVPKDLLCNLE----LEGKITDLQKE 728
Query: 165 LEAILTENQFLKQ--LQLRHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQEKER 222
L + EN+ L++ + L LK++ +EV+ LR+ ++ E+
Sbjct: 729 LNKEVEENEALREEVILLSELKSL-----------------PSEVERLRKEIQDKSEELH 771
Query: 223 TLSRKLRETDSQLLKTKDILQAL-QKLSEDKNLAEREELTHKLS------IITTKMDAND 275
++ + + S+++ + +Q L +++ + K+ + +K + T MD
Sbjct: 772 IITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQ 831
Query: 276 KKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKDRELEIKN 335
K LE+ R+N + L+ E +K ++ A KT E+ + Q+L+EK RE++ +
Sbjct: 832 KYKMVLEENERMNQEIVN--LSKEAQKFDSSLGALKT---ELSYKTQELQEKTREVQERL 886
Query: 336 IYSHRILKNLHDTED-YPKVSSTKSVQADRKILPFTSMRHQGTQKSDVPPL-----TTKG 389
++ + L + + V K++ ++ ++ +K D+ L +
Sbjct: 887 NEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERD 946
Query: 390 KKATGNIDHKEKSTEINHEIPHCVNKLPKQEDS----KRKYEDLSGEEKHLEVQILLENT 445
+ + D + + ++ + + L + +++ K K + H+E ENT
Sbjct: 947 QLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHME-----ENT 1001
Query: 446 GRQK----------DKKEDQEKKN-----IFVKEEQ--ELPPKIIEVIHPERESNQ--ED 486
G K DKK+D E KN VK+ + E KI +I + E Q E
Sbjct: 1002 GETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLES 1061
Query: 487 VLV-REKFKRSMQRN 500
V+ +E+ K ++ N
Sbjct: 1062 VIAEKEQLKTDLKEN 1076
Score = 42.0 bits (97), Expect = 0.002
Identities = 67/391 (17%), Positives = 172/391 (43%), Gaps = 41/391 (10%)
Query: 90 VKEKEKKKYNVSKISQSKGQKEISVEKKHTWNASLFNSQIHMIAQRRDAMAHRILSARLH 149
V E +KK + ++ + + +++ K N +L + + + M R R+
Sbjct: 1839 VNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVE 1898
Query: 150 KIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGK-YENSQNNLPQIMAKHQNEVK 208
+ LK E + L+ + ++Q +L+ + + K ++ + + L + +++ ++
Sbjct: 1899 ET--LKLERDQLKESLQETKARDLEIQQ-ELKTARMLSKEHKETVDKLREKISEKTIQIS 1955
Query: 209 NLRQLLRKSQEKERTLSRKLRETDSQLLKTK-DILQALQKLSEDKNLAEREELTHKLSII 267
++++ L KS+++ + ++L++ + QLL+ K D+ + +K++E + L ++ E LS+
Sbjct: 1956 DIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFE-AQNLSMQ 2014
Query: 268 TTKMD--ANDKKIQSLEKQLRLNCR--------------------AFSRQLAIETRKTLA 305
+ +MD KK+ +++R+ + A R++ R+
Sbjct: 2015 SVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQ 2074
Query: 306 AQTATKTLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRK 365
+ + L +HL + L+EK ++ +LK + +D+ + + S+ +++
Sbjct: 2075 VKPEKRLLSDGQQHLTESLREKCSRIK-------ELLKRYSEMDDHYECLNRLSLDLEKE 2127
Query: 366 ILPFTSMRHQGTQKSDVPPLTTK--GKKATGN----IDHKEKSTEINHEIPHCVNKLPKQ 419
I + + +P L TK K T N ++ ++ + + + +Q
Sbjct: 2128 IEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQ 2187
Query: 420 EDSKRKYEDLSGEEKHLEVQILLENTGRQKD 450
+S K+E +E + ++L++ Q+D
Sbjct: 2188 HESINKFEMDFIDEVEKQKELLIKIQHLQQD 2218
Score = 41.6 bits (96), Expect = 0.002
Identities = 72/360 (20%), Positives = 153/360 (42%), Gaps = 41/360 (11%)
Query: 160 DMHHKLEAILTENQFLKQLQLRHL-KAIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQ 218
+ +L + N L LQ +H+ K + +IM K + + + ++ +
Sbjct: 2129 EFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKI---KE 2185
Query: 219 EKERTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAEREELTHKLSIITTKMDANDKKI 278
E+ ++++ + ++ K K++L +Q L +D ++ RE KL+ MD + ++I
Sbjct: 2186 EQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLN---QNMDLHIEEI 2242
Query: 279 QSLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQV--EVKHLQQKL-KEKDRELEIKN 335
+ Q + RK + Q + L +++ L+ + KE DR ++ N
Sbjct: 2243 LKDFSESEFPSIKTEFQQVLSNRKEMT-QFLEEWLNTRFDIEKLKNGIQKENDRICQVNN 2301
Query: 336 IYSHRILKNLHDTEDYPKVSSTKSVQADRKILPFTSMRHQGTQKSDVPPLTTKGKKATGN 395
+++RI+ ++++ ++ + S+T S + ++ D+ L K +K N
Sbjct: 2302 FFNNRIIAIMNESTEFEERSATISKEWEQ----------------DLKSLKEKNEKLFKN 2345
Query: 396 IDHKEKSTEINHEIPHCVNKLPKQEDSKRKYEDLSGEEKHLEVQILLENTGRQ-KDKKED 454
+ S ++ P +D+K + + E LEN+ + K+
Sbjct: 2346 YQTLKTSLASGAQVN------PTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMH 2399
Query: 455 QEKKNIFVKEEQELPPKIIEVIHPE-RESNQEDVLVREKFKRSMQRNGVDDTLGKGTAPY 513
+E K I +++E E+ II + + ESN+ EK K ++Q + D + G PY
Sbjct: 2400 KESKIIKMQKELEVTNDIIAKLQAKVHESNK----CLEKTKETIQ--VLQDKVALGAKPY 2453
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 62.0 bits (149), Expect = 2e-09
Identities = 95/441 (21%), Positives = 192/441 (43%), Gaps = 69/441 (15%)
Query: 86 KQPVVKEKEKKKYNVSKISQ-----SKGQKEISVEK-KHTWNASLFNSQIHM-----IAQ 134
K+ V+K+KEK K+ Q +K Q++++ EK K ++ + + IA+
Sbjct: 1899 KETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAK 1958
Query: 135 RRDAM---AHRILSARLHKIKGL----KNELADMHHKLEAILTENQF------LKQLQLR 181
A+ R+ ++ ++G K E + + + E + L++ L
Sbjct: 1959 EEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILL 2018
Query: 182 HLKAIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQL----LK 237
H I E S+ +AK + E +++ + Q K SRKL + L K
Sbjct: 2019 HEDRILAMEESE------IAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAK 2072
Query: 238 TKDILQALQKLSEDKNLAEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSR--- 294
IL+ALQKL+ D+ +EE+ K++ + + ++++ + +L + FS
Sbjct: 2073 LNKILKALQKLTRDERKLTQEEI--KMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRS 2130
Query: 295 QLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKV 354
+L + +K Q + + ++K+ E++ +L K +S IL D E+ +
Sbjct: 2131 ELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARK--HSEVIL----DDEEEGGI 2184
Query: 355 SSTKSVQADRKILPFTSMR---HQGTQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPH 411
+ +++PF R + ++ D P +K + +D E + E+
Sbjct: 2185 E-------EEEVIPFLKRRWRKRKEAKRGDKPK-----EKFSSQVDEVESEEHFSEEMES 2232
Query: 412 CVNKLPKQEDSKRKYEDLSGEEKHLEVQILLENTGRQKDKKEDQEKKNIFVKEEQELPPK 471
+++L KQE + E+ EE+ E + + E +K+++E +EK+ KEE+E K
Sbjct: 2233 LLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQ--VEKEEEEKKKK 2290
Query: 472 IIEVIHPERESNQEDVLVREK 492
++E +E+V +E+
Sbjct: 2291 -------KKEKKKEEVQEKEE 2304
Score = 49.3 bits (116), Expect = 1e-05
Identities = 118/571 (20%), Positives = 226/571 (39%), Gaps = 55/571 (9%)
Query: 89 VVKEKEKKKYNVSKISQSKGQ----KEISVEKKHTWNASLFNSQIHMIAQRRDAMAHRIL 144
+++EKEK + K+ + + + +E +EKK L + I + ++++
Sbjct: 1777 LIQEKEKLAQHKEKMPEEEERLGRKREQLIEKK----MKLAQKRERWINSMEELTKNKMI 1832
Query: 145 SARLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRH-LKAIGKYENSQNNLPQIMAKH 203
+ + K LA KL A EN + +L H K + + +N +I+A+
Sbjct: 1833 LYQKKNLAQEKKNLAQEKEKL-AQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQV 1891
Query: 204 QNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKD-ILQALQKLSEDKNLAE-REELT 261
+ ++ ++ + K +EK +KL + + L K ++ + Q KL+ +K + + ++ L
Sbjct: 1892 EEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLR 1951
Query: 262 HKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLA-AQTATKTLQVEVKHL 320
+L I + N + + E+++RL +E ++TL+ +T + Q ++ +
Sbjct: 1952 GELDIAKEEKALNLEMKRLAEEKMRL----------VEGKETLSKGETPETSRQRKMTQV 2001
Query: 321 QQKLKEKDRELEIK-NIYSHRILKNLHDTEDYPKVSSTKS----VQADRKILPFT-SMRH 374
+Q+L E+ LE K ++ RIL K+ T+ VQ RK+ + +
Sbjct: 2002 EQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIK 2061
Query: 375 QGTQKSDVPPLTTKGKKATGNIDHKE--------KSTEINHEIPHCVNKLP--------K 418
+ S P K KA + E K T++ + +L K
Sbjct: 2062 KRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIK 2121
Query: 419 QEDSKRKYEDLSGEEKHL-EVQILLENTGRQKDKKEDQEKKNIFVKEEQELPPKIIEVI- 476
+ D K +L+ +EK L Q L N R+ KE++ +EE +L K EVI
Sbjct: 2122 EWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEK-----MTEEESKLARKHSEVIL 2176
Query: 477 HPERESNQEDVLVREKFKRSMQRNGVDDTLGKGTAPYTKGPLRQRRHYSFTEATENLHHG 536
E E E+ V KR ++ K ++ F+E E+L
Sbjct: 2177 DDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDE 2236
Query: 537 LPASGGPANAGNMRYSHSTGKHLS--NREEMELEHSDSGYEPSFGKSSRIKVKDTTFRDK 594
L ++ + EE E + + G E K K K + K
Sbjct: 2237 LEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKK 2296
Query: 595 KS-SLMEELFGSGYVLKTDQSSPGVAKGSEE 624
+ EE+F + +++ + ++ EE
Sbjct: 2297 EEVQEKEEVFEEKEEIMSEEETESLSDEEEE 2327
Score = 30.4 bits (67), Expect = 5.5
Identities = 82/432 (18%), Positives = 162/432 (37%), Gaps = 55/432 (12%)
Query: 69 EDFLCDCSEKAINRNYLKQPVVKEKEKKKYNVSKISQS-----KGQKEISVEKKHTWNAS 123
ED + +++ I + ++ +KK ++ + ++ KG+K I +E +
Sbjct: 1326 EDMIQGVTQEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGK 1385
Query: 124 LFNSQIHMIAQRRDAMAHRILSARLHKIKGLKNELA----DMHHKLEAILTENQFLKQLQ 179
+ + ++ R + K+ +K E+ DM ++E + T L+
Sbjct: 1386 EISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMAT-------LE 1438
Query: 180 LRHLKAIGKYENSQNNLP-QIMAKHQNEVKNLRQLLRKSQE--KERTLSRKLRETDSQLL 236
+ +K GK + Q K +E K + RKS + KE R L+E +
Sbjct: 1439 EKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQ 1498
Query: 237 KTKDILQALQKLSEDKNLAERE---ELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFS 293
+ + + L EDK L E + LS + + D++ +LE+++
Sbjct: 1499 AGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKE 1558
Query: 294 RQLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPK 353
+Q+ E R ++ +H ++ K E K R L E+
Sbjct: 1559 QQVTEEQR------------HIQEEHKWARIHRKRARAEKKRAQEER---KLAQEEEKLA 1603
Query: 354 VSSTKSVQADRKILPFTSMRHQGTQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCV 413
+ Q +RK+ + + + D +GK A ++ +++ E
Sbjct: 1604 QEERQLAQEERKL----AQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLA 1659
Query: 414 NKLPKQEDSKRKYEDLSGEEKHLEVQILLENTGRQKDKKEDQEKKNIFVKEEQELPPKII 473
K K +K+E ++ EE+ L K + E KNI ++ +ELP +
Sbjct: 1660 QKRKKLA---KKWEKVAREEEKLA-----------KKGGKLAEVKNILAQKVEELPQREQ 1705
Query: 474 EVIHPERESNQE 485
+ E+E QE
Sbjct: 1706 NLDWQEKELAQE 1717
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 62.0 bits (149), Expect = 2e-09
Identities = 84/445 (18%), Positives = 190/445 (42%), Gaps = 40/445 (8%)
Query: 74 DCSEKAINRNYLKQPVVKEKEKKKYNVSKISQSKGQKEISVEKKHTWNASLFNSQIHMIA 133
D + RN + +KEK K ++ +S+ + EI + K L +++ +
Sbjct: 264 DALSLELYRNTITDEELKEKNAKLQEKLQLVESE-KSEIQLNVKEL-KRKLERAKLLLPQ 321
Query: 134 QRRDAMAHRILSARLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQ 193
Q+ A A L EL + KL+A + EN+ +L + + + + E
Sbjct: 322 QQLQAEADH-----------LGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKI 370
Query: 194 NNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDIL---------QA 244
+ + + + +++ + +R+ +EK R + E + ++ + ++++ Q
Sbjct: 371 QEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQE 430
Query: 245 LQKLSEDKNLAEREELTHKLSIITTKMD--ANDKKIQSLEKQLRLNCRAFSRQLAI-ETR 301
+++ + E EE H+ I + + ++KI+ EK+ + + ++ I E
Sbjct: 431 EMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE 490
Query: 302 KTLAAQTATKTLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQ 361
+ + Q Q E H Q+K++E+++ E + ++ R + + + E+ + Q
Sbjct: 491 EKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMW--RQEEKIREQEEIWRQKEKIHEQ 548
Query: 362 ADRKILPFTSMRHQGTQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVNKLPKQED 421
++ M Q + D + ++ +EK E +I K+ +QE+
Sbjct: 549 EEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWR--QEEKIREQEEKIREQEEKIREQEE 606
Query: 422 SKRKYEDLSGE------EKHLEVQILLENTGRQKDKKEDQEKKNIFVKEEQELPPKIIEV 475
++ E+ GE E+ ++Q E RQ++K +QEKK ++E++E + E+
Sbjct: 607 MTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKK---IREQEEKIREQEEM 663
Query: 476 IHPERES--NQEDVLVREKFKRSMQ 498
+ + E QE+ + ++ K Q
Sbjct: 664 MQEQEEKMWEQEEKMCEQEEKMQEQ 688
>gi|30794488 kinesin family member 27 [Homo sapiens]
Length = 1401
Score = 62.0 bits (149), Expect = 2e-09
Identities = 80/342 (23%), Positives = 142/342 (41%), Gaps = 52/342 (15%)
Query: 214 LRKSQEKERTLS---RKLRETDSQLLKTKDILQALQKLSEDKNLAEREELTHKLSIITTK 270
L+K + ER L+ +K+RE + +D+++ L K D ++ + L + +
Sbjct: 709 LQKLKNSERILTEAKQKMRELTINIKMKEDLIKELIKTGNDAKSVSKQ---YSLKVTKLE 765
Query: 271 MDANDKKIQSLEKQLRL----NCRAFSRQLAIETRKTLAAQTATKTLQVEVKHLQQKLKE 326
DA K++ +E Q +L N + ++ +K + L+V+V +Q+ +
Sbjct: 766 HDAEQAKVELIETQKQLQELENKDLSDVAMKVKLQKEFRKKMDAAKLRVQVLQKKQQDSK 825
Query: 327 KDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQAD---RKILPFTSMRHQGTQKS--- 380
K L I+N L+ D Y K+ + ++ + RK L R Q K
Sbjct: 826 KLASLSIQNEKRANELEQSVDHMKYQKIQLQRKLREENEKRKQLDAVIKRDQQKIKEIQL 885
Query: 381 -------------DVPPLTTKGKKAT-GNIDHKEKSTE----INHEIPHCVNK------- 415
D+ K +K + G+IDH +K E ++ E+ +N+
Sbjct: 886 KTGQEEGLKPKAEDLDACNLKRRKGSFGSIDHLQKLDEQKKWLDEEVEKVLNQRQELEEL 945
Query: 416 ---LPKQEDSKRKYEDLSGEEKHLEVQILLENTGRQKDKKEDQEKKNIFVKEEQELPPKI 472
L K+E K E L E+ HLE + L + D + + N+ EQEL K
Sbjct: 946 EADLKKREAIVSKKEALLQEKSHLENKKLRSSQALNTDSLKISTRLNLL---EQELSEKN 1002
Query: 473 IEVIHPERE-----SNQEDVLVREKFKRSMQRNGVDDTLGKG 509
+++ E S Q +VL +EK + +R+ VD+ L G
Sbjct: 1003 VQLQTSTAEEKTKISEQVEVLQKEKDQLQKRRHNVDEKLKNG 1044
Score = 35.0 bits (79), Expect = 0.22
Identities = 48/232 (20%), Positives = 91/232 (39%), Gaps = 38/232 (16%)
Query: 74 DCSEKAINRNYLKQPVVKEKEKKKYNVSKISQSKGQKEISVEKKHTWNASLFNSQI---- 129
+ SEK + L+ +EK K V + + K Q + +++H + L N ++
Sbjct: 997 ELSEKNVQ---LQTSTAEEKTKISEQVEVLQKEKDQLQ---KRRHNVDEKLKNGRVLSPE 1050
Query: 130 --HMIAQRRDAMA--HRILSARLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKA 185
H++ Q + + + R I+ + L H L E L++L
Sbjct: 1051 EEHVLFQLEEGIEALEAAIEYRNESIQNRQKSLRASFHNLSR--GEANVLEKLACL---- 1104
Query: 186 IGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQAL 245
S + I+ ++ N+V NLR+ RK Q + K+ E D+ + + + L L
Sbjct: 1105 ------SPVEIRTILFRYFNKVVNLREAERKQQLYNEEMKMKVLERDNMVRELESALDHL 1158
Query: 246 QKLSEDKNLAEREELTHKLSIITTKMDAND------------KKIQSLEKQL 285
+ + + +++E K+ ++ D KIQ LEK L
Sbjct: 1159 KLQCDRRLTLQQKEHEQKMQLLLHHFKEQDGEGIMETFKTYEDKIQQLEKDL 1210
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 60.8 bits (146), Expect = 4e-09
Identities = 78/422 (18%), Positives = 184/422 (43%), Gaps = 32/422 (7%)
Query: 74 DCSEKAINRNYLKQPVVKEKEKKKYNVSKISQSKGQKEISVEKKHTWNASLFNSQIHMIA 133
D + RN + +KEK K ++ +S+ + EI + K L +++ +
Sbjct: 203 DALSLELYRNTITDEELKEKNAKLQEKLQLVESE-KSEIQLNVKEL-KRKLERAKLLLPQ 260
Query: 134 QRRDAMAHRILSARLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQ 193
Q+ A A L EL + KL+A + EN+ +L + + + + E
Sbjct: 261 QQLQAEADH-----------LGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKI 309
Query: 194 NNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQKLS--ED 251
+ + + + +++ + +R+ +EK R + E + ++ + ++++ ++ ++
Sbjct: 310 QEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQE 369
Query: 252 KNLAEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTATK 311
+ + E+EE K+ M ++KI+ LE+++ + ++ + + + Q +
Sbjct: 370 EMMWEKEE---KMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQ 426
Query: 312 TLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKILPFTS 371
+ ++ ++K++E++ ++ + R + +H+ E K+ + Q ++
Sbjct: 427 EQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQE---KIREEEKRQEQEEMWRQEE 483
Query: 372 MRHQGT----QKSDVPPLTTKGKKATGNI-DHKEKSTEINHEIPHCVNKLPKQEDSKRKY 426
H+ QK + K +K + +EK E +I K+ +QE+ R+
Sbjct: 484 KIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQ 543
Query: 427 EDLSGEEKHLEVQILL---ENTGRQKDKKEDQEKKNIFVKEEQELPPKIIEVIHPERESN 483
E++ EE+ + Q + E Q+DK QE+K ++E++E + E I + E
Sbjct: 544 EEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEK---IREQEEKVWRQEEKIREQEEKR 600
Query: 484 QE 485
QE
Sbjct: 601 QE 602
Score = 45.4 bits (106), Expect = 2e-04
Identities = 68/317 (21%), Positives = 139/317 (43%), Gaps = 47/317 (14%)
Query: 192 SQNNLPQIMAKHQNEVKNLRQLLRKSQEKERTLS------RKLRETDSQLLKTKDILQAL 245
SQ+ + Q+ + ++ + L + + E E+ LS +K +L K +D L
Sbjct: 149 SQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALS-- 206
Query: 246 QKLSEDKNLAEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLA 305
L +N EEL K + + K+ ++S + +++LN + R+L E K L
Sbjct: 207 --LELYRNTITDEELKEKNAKLQEKLQL----VESEKSEIQLNVKELKRKL--ERAKLLL 258
Query: 306 AQTATKTLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRK 365
Q + LQ E HL ++L+ +L+ + + + + L+ ++ K + + K
Sbjct: 259 PQ---QQLQAEADHLGKELQSVSAKLQAQ-VEENELWNRLNQQQE------EKMWRQEEK 308
Query: 366 ILPFTSMRHQGTQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVNKLPKQEDSKRK 425
I + + +K + +EK E ++ + ++E+ R+
Sbjct: 309 IQEWEEKIQEQEEKIR---------------EQEEKIREQEEKMRRQEEMMWEKEEKMRR 353
Query: 426 YEDLSGEEKHLEVQILLENTGRQKDKKEDQEKKNIFVKEEQ--ELPPKIIEV--IHPERE 481
E++ E++ E E +K++K ++++ ++ KEE+ EL K+ E I + E
Sbjct: 354 QEEMMWEKE--EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEE 411
Query: 482 SNQEDVLVREKFKRSMQ 498
QE+ +RE+ KR Q
Sbjct: 412 KRQEEEKIREQEKRQEQ 428
Score = 44.7 bits (104), Expect = 3e-04
Identities = 83/442 (18%), Positives = 182/442 (41%), Gaps = 57/442 (12%)
Query: 91 KEKEKKKYNVSKISQSKGQKEISVEKKHTWNASLFNSQIHMIAQRRDAMAHRILSARLHK 150
+++EK + KI Q + +K E+K Q M+ ++ + M R K
Sbjct: 304 RQEEKIQEWEEKI-QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKM-RRQEEMMWEK 361
Query: 151 IKGLKNELADMHHKLEAILTENQFL--KQLQLRHLKAIGKYENSQNNLPQIMAKHQNEVK 208
+ ++ + M K E + + + + K+ ++R L+ + + Q + + K Q E K
Sbjct: 362 EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE---EKMHEQEKIREQEEKRQEEEK 418
Query: 209 NLRQLLRKSQE--------KERTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAEREEL 260
Q R+ QE K R K+RE + ++ + ++ + +K+ E++ E+EE+
Sbjct: 419 IREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEM 478
Query: 261 THKLSIITTKMDA--NDKKIQSLEKQLRLNCRAFSRQ---LAIETRKTLAAQTATKTLQV 315
+ I + + +K+ E+++R RQ + + K + +
Sbjct: 479 WRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEE 538
Query: 316 EVKHLQQKLKEKDRELEIKNIYSHRILKNLHDT----EDYPKVSSTKSVQADRKILPFTS 371
+++ ++ +E+++ E + I+ + D E+ + K + + KI
Sbjct: 539 KIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEE 598
Query: 372 MRHQGTQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVNKLPKQEDSKRKYEDLSG 431
R + +K +EK E +I K+ +QE+ R+ E+++
Sbjct: 599 KRQEQEEKM---------------WKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQ 643
Query: 432 E-------------EKHLEVQILLENTGRQKDKKEDQEKKNIFVKEEQELPPKIIEVIHP 478
E E+ ++Q E RQ++K +QEKK ++E++E + E++
Sbjct: 644 EQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKK---IREQEEKIREQEEMMQE 700
Query: 479 ERES--NQEDVLVREKFKRSMQ 498
+ E QE+ + ++ K Q
Sbjct: 701 QEEKMWEQEEKMCEQEEKMQEQ 722
Score = 43.1 bits (100), Expect = 8e-04
Identities = 72/383 (18%), Positives = 160/383 (41%), Gaps = 55/383 (14%)
Query: 129 IHMIAQRRDAMAHRILSARLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGK 188
I + + RDA++ + + + LK + A + KL+ + +E + QL ++ LK K
Sbjct: 195 IEELTKERDALSLELYRNTITD-EELKEKNAKLQEKLQLVESEKSEI-QLNVKELKR--K 250
Query: 189 YENSQNNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQL---LKTKDILQAL 245
E ++ LPQ ++ Q + L ++L+ ++L ++ ++ L
Sbjct: 251 LERAKLLLPQ----------------QQLQAEADHLGKELQSVSAKLQAQVEENELWNRL 294
Query: 246 QKLSEDKNLAEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLA 305
+ E+K + E K+ K+ ++KI+ E+++R RQ + K
Sbjct: 295 NQQQEEKMWRQEE----KIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEK--- 347
Query: 306 AQTATKTLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRK 365
+ +++ ++ + EK+ ++ + + + E+ K + + K
Sbjct: 348 --------EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEK 399
Query: 366 ILPFTSMRHQGTQKSDVPPLTTKGKKATGNID---HKEKSTEINHEIPHCVNKLPKQEDS 422
+ +R Q ++ + + + K+ +EK E +I K+ +QE+
Sbjct: 400 MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEK 459
Query: 423 KRKYEDLSGEEKHLEVQIL---------LENTGRQKDKKEDQEKKNIFVKEEQELPPKII 473
+ E + EEK E + + E RQK+K +QE+K +++++E +
Sbjct: 460 IHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEK---IRKQEEKVWRQE 516
Query: 474 EVIHPERES--NQEDVLVREKFK 494
E I + E QE+ + R++ K
Sbjct: 517 EKIREQEEKIREQEEKMWRQEEK 539
Score = 34.7 bits (78), Expect = 0.29
Identities = 33/203 (16%), Positives = 94/203 (46%), Gaps = 18/203 (8%)
Query: 86 KQPVVKEKEKKKYNVSKISQSKGQKEISVEKKHTWNASLFNSQIHMIAQRRDAMAHRILS 145
+Q + E+EK++ K+ + +++I +++ W +I ++R ++
Sbjct: 555 EQEKIWEEEKRQEQEDKMWRQ--EEKIREQEEKVWRQE---EKIREQEEKRQEQEEKMWK 609
Query: 146 ARLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQN 205
KI+ + ++ + K+ E + +Q ++ + E + M + +
Sbjct: 610 QE-EKIREQEEKIQEQEEKIRE--QEEKIREQEEMTQ-----EQEEKMGEQEEKMCEQEE 661
Query: 206 EVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQK--LSEDKNLAEREELTHK 263
+++ + + + +EK R +K+RE + ++ + ++++Q ++ +++ + E+EE K
Sbjct: 662 KMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE---K 718
Query: 264 LSIITTKMDANDKKIQSLEKQLR 286
+ KM ++K+ E +LR
Sbjct: 719 MQEQEEKMRRQEEKMWEQEVRLR 741
Score = 29.6 bits (65), Expect = 9.4
Identities = 44/271 (16%), Positives = 117/271 (43%), Gaps = 27/271 (9%)
Query: 86 KQPVVKEKEKKKYNVSKISQSKGQKEISVEKKHTWNAS-LFNSQIHMIAQRRDAMAHRIL 144
+Q ++E+EK++ + Q+E E++ W + Q I ++ + + +
Sbjct: 462 EQEKIREEEKRQEQ----EEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEE 517
Query: 145 SARLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQ 204
R + K ++ + M + E I + + ++ + H + E + M + +
Sbjct: 518 KIREQEEK-IREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQE 576
Query: 205 NEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKD-ILQALQKLSE--------DKNLA 255
+++ + + + +EK R K +E + ++ K ++ I + +K+ E ++ +
Sbjct: 577 EKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIR 636
Query: 256 EREELT----HKLSIITTKMDANDKKIQSLEKQL--------RLNCRAFSRQLAIETRKT 303
E+EE+T K+ KM ++K+Q E+ + + ++ I ++
Sbjct: 637 EQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEE 696
Query: 304 LAAQTATKTLQVEVKHLQQKLKEKDRELEIK 334
+ + K + E K +Q+ K +++E +++
Sbjct: 697 MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMR 727
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 60.8 bits (146), Expect = 4e-09
Identities = 81/433 (18%), Positives = 184/433 (42%), Gaps = 45/433 (10%)
Query: 74 DCSEKAINRNYLKQPVVKEKEKKKYNVSKISQSKGQKEISVEKKHTWNASLFNSQIHMIA 133
D + RN + +KEK K ++ +S+ + EI + K L +++ +
Sbjct: 203 DALSLELYRNTITDEELKEKNAKLQEKLQLVESE-KSEIQLNVKEL-KRKLERAKLLLPQ 260
Query: 134 QRRDAMAHRILSARLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQ 193
Q+ A A L EL + KL+A + EN+ +L + + + + E
Sbjct: 261 QQLQAEADH-----------LGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKI 309
Query: 194 NNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDIL----QALQKLS 249
+ + + + +++ + +R+ +EK R + E + ++ + ++++ + +++L
Sbjct: 310 QEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLE 369
Query: 250 E-----DKNLAEREELTHKLSIITTKMD--ANDKKIQSLEKQLRLNCRAFSRQLAI-ETR 301
E ++ + E EE H+ I + + ++KI+ EK+ + + ++ I E
Sbjct: 370 EMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE 429
Query: 302 KTLAAQTATKTLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQ 361
+ + Q Q E H Q+K++E+++ E + ++ K+ + +
Sbjct: 430 EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE-----------EKIREQEEIW 478
Query: 362 ADRKILPFTSMRHQGTQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVNKLPKQED 421
++ M Q + + + +K D +EK E ++ K+ +QE+
Sbjct: 479 RQKE-----KMHEQEKIRKQEEKVWRQEEKMH---DQEEKIREQEEKMWRQEEKIREQEE 530
Query: 422 SKRKYEDLSGEEKHLEVQILLENTGRQKDKKEDQEKKNIFVKEEQELPPKIIEVIHPERE 481
R+ E+ E++ + +Q E G Q++K ++QEK ++ +E KI E RE
Sbjct: 531 KIREQEEKIREQEEM-MQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIRE 589
Query: 482 SNQEDVLVREKFK 494
++ EK +
Sbjct: 590 QEEKIWEQEEKIR 602
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 60.1 bits (144), Expect = 7e-09
Identities = 78/355 (21%), Positives = 147/355 (41%), Gaps = 53/355 (14%)
Query: 38 FSRNSNASNKSVDYSRSQCSCGSLSSQYDYSEDFLCDCSEKAINRNYLKQPVVKEKEKKK 97
F+ + +K+V +S +LS + D L D S+K +K+ +V+E K+
Sbjct: 1025 FTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQT 1084
Query: 98 YNVSKISQSKGQKEISVEK----KHTWNASLFNSQIHMIAQRRDAMAHRILSARLHKIKG 153
+ + ++ + +E+ K + N ++ N + + + +R + +LH++
Sbjct: 1085 SEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQL-- 1142
Query: 154 LKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQL 213
L+N+ E + + F K++ + K E SQN + ++ +K Q+EV+N +Q
Sbjct: 1143 LENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEV-SKLQSEVQNTKQA 1201
Query: 214 LRKSQ-------------------------EKERTLSRKLRETDSQLLKTK--------- 239
L+K + EK L+RK E ++L K
Sbjct: 1202 LKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDE 1261
Query: 240 ------DILQALQKLSE--DKNLAEREELTHKLSIITTKMDANDKKIQSL---EKQLRLN 288
I Q ++ E DK+L EL ++ +++A D KI L ++L+
Sbjct: 1262 KELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQA 1321
Query: 289 CRAFSRQLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKDRE-LEIKNIYSHRIL 342
S+ T TLQ +VK L+Q+L + DR+ E+ IY +L
Sbjct: 1322 LNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLL 1376
Score = 46.6 bits (109), Expect = 7e-05
Identities = 84/434 (19%), Positives = 185/434 (42%), Gaps = 63/434 (14%)
Query: 103 ISQSKGQKEISVEKKHTWNASLFN--SQIHMIAQRRDAMAHRILSARLH------KIKGL 154
++Q +K++ +EK N SL S++ + + I++ + + ++ L
Sbjct: 758 VTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSEL 817
Query: 155 KNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQNEV------- 207
K + + K+ A+ +EN LK++ + +E + L +AK E+
Sbjct: 818 KKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKF 877
Query: 208 KNLRQLLRKSQEKERTLSRKLRETDSQL-----------LKTKDILQALQKLSEDKN--- 253
+++ Q K ++K L R L T +Q+ K + Q+++K+ +D N
Sbjct: 878 EDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKV-QDSNAEI 936
Query: 254 LAEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIE-----TRKTLAAQT 308
LA + ++ + ++ A K++ ++++ +++ E T K L Q
Sbjct: 937 LANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQL 996
Query: 309 ATKTLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKILP 368
+ +T + V + K +++ + K I++ + K+L D V KS + +R +
Sbjct: 997 SEQTQKYSVSEEEVKKNKQENDKLKKEIFT--LQKDLRD----KTVLIEKSHEMERALSR 1050
Query: 369 FTSMRHQGTQKSDVPPLTTKGKKATGNIDHK--EKSTEINHEIPHCVNKLPKQEDSKRKY 426
T ++ Q D+ T+ K N+ K E++ + EI N L KQ +
Sbjct: 1051 KTDELNK--QLKDLSQKYTEVK----NVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQV 1104
Query: 427 EDLSGEEKHLEVQILLENTGRQKDKKEDQEKKNIFVKEEQELPPKIIEVIHPERESN--- 483
E L +K L G ++ KE+ + ++EQ+ K+ +++ ++ S+
Sbjct: 1105 EAL---KKSL--------NGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPL 1153
Query: 484 QEDVLVREKFKRSM 497
E + ++E F++ +
Sbjct: 1154 AEHLQIKEAFEKEV 1167
Score = 32.0 bits (71), Expect = 1.9
Identities = 79/443 (17%), Positives = 169/443 (38%), Gaps = 68/443 (15%)
Query: 82 RNYLKQPVVKEKEKKKYNVSKISQSKG-QKEISV-----EKKHTWNASLFNSQIHMIAQR 135
RN +KQ + +E K+ I ++K QKE+S+ EKK M Q
Sbjct: 551 RNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG-------RKVTEMEGQA 603
Query: 136 RDAMAHRILSARLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNN 195
++ A LS K + +K+ L++ +
Sbjct: 604 KELSAKLALSIPAEKFENMKSSLSN---------------------------EVNEKAKK 636
Query: 196 LPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQKLSE-DKNL 254
L ++ +H+ + +RQL R+ + + L++ ++ + + +K++ QK E K +
Sbjct: 637 LVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSR----LEQKSGELGKKI 692
Query: 255 AEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQ 314
E L K+ ++K ++ L + + L + + L
Sbjct: 693 TELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLN 752
Query: 315 VEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDY--------PKVSSTKSVQADRKI 366
++ + QK EK E+E + + + K++ E ++ + KS + K
Sbjct: 753 RKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKK 812
Query: 367 LPFTSMRHQGTQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVN-KLPKQE----D 421
+ G + + LT++ + ++ + + E+ +N L K D
Sbjct: 813 QLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLD 872
Query: 422 SKRKYEDLSGE-----EKHLEVQILLENTGRQKDKK-----EDQEKKNIFVKEEQELPPK 471
K+K+ED++ E +K+ ++ LENT Q + E + K + + +++
Sbjct: 873 VKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDS 932
Query: 472 IIEVIHPERESNQEDVLVREKFK 494
E++ R+ +E V + + K
Sbjct: 933 NAEILANYRKGQEEIVTLHAEIK 955
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 60.1 bits (144), Expect = 7e-09
Identities = 78/355 (21%), Positives = 147/355 (41%), Gaps = 53/355 (14%)
Query: 38 FSRNSNASNKSVDYSRSQCSCGSLSSQYDYSEDFLCDCSEKAINRNYLKQPVVKEKEKKK 97
F+ + +K+V +S +LS + D L D S+K +K+ +V+E K+
Sbjct: 1038 FTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQT 1097
Query: 98 YNVSKISQSKGQKEISVEK----KHTWNASLFNSQIHMIAQRRDAMAHRILSARLHKIKG 153
+ + ++ + +E+ K + N ++ N + + + +R + +LH++
Sbjct: 1098 SEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQL-- 1155
Query: 154 LKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQL 213
L+N+ E + + F K++ + K E SQN + ++ +K Q+EV+N +Q
Sbjct: 1156 LENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEV-SKLQSEVQNTKQA 1214
Query: 214 LRKSQ-------------------------EKERTLSRKLRETDSQLLKTK--------- 239
L+K + EK L+RK E ++L K
Sbjct: 1215 LKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDE 1274
Query: 240 ------DILQALQKLSE--DKNLAEREELTHKLSIITTKMDANDKKIQSL---EKQLRLN 288
I Q ++ E DK+L EL ++ +++A D KI L ++L+
Sbjct: 1275 KELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQA 1334
Query: 289 CRAFSRQLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKDRE-LEIKNIYSHRIL 342
S+ T TLQ +VK L+Q+L + DR+ E+ IY +L
Sbjct: 1335 LNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLL 1389
Score = 46.6 bits (109), Expect = 7e-05
Identities = 84/434 (19%), Positives = 185/434 (42%), Gaps = 63/434 (14%)
Query: 103 ISQSKGQKEISVEKKHTWNASLFN--SQIHMIAQRRDAMAHRILSARLH------KIKGL 154
++Q +K++ +EK N SL S++ + + I++ + + ++ L
Sbjct: 771 VTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSEL 830
Query: 155 KNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQNEV------- 207
K + + K+ A+ +EN LK++ + +E + L +AK E+
Sbjct: 831 KKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKF 890
Query: 208 KNLRQLLRKSQEKERTLSRKLRETDSQL-----------LKTKDILQALQKLSEDKN--- 253
+++ Q K ++K L R L T +Q+ K + Q+++K+ +D N
Sbjct: 891 EDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKV-QDSNAEI 949
Query: 254 LAEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIE-----TRKTLAAQT 308
LA + ++ + ++ A K++ ++++ +++ E T K L Q
Sbjct: 950 LANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQL 1009
Query: 309 ATKTLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKILP 368
+ +T + V + K +++ + K I++ + K+L D V KS + +R +
Sbjct: 1010 SEQTQKYSVSEEEVKKNKQENDKLKKEIFT--LQKDLRD----KTVLIEKSHEMERALSR 1063
Query: 369 FTSMRHQGTQKSDVPPLTTKGKKATGNIDHK--EKSTEINHEIPHCVNKLPKQEDSKRKY 426
T ++ Q D+ T+ K N+ K E++ + EI N L KQ +
Sbjct: 1064 KTDELNK--QLKDLSQKYTEVK----NVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQV 1117
Query: 427 EDLSGEEKHLEVQILLENTGRQKDKKEDQEKKNIFVKEEQELPPKIIEVIHPERESN--- 483
E L +K L G ++ KE+ + ++EQ+ K+ +++ ++ S+
Sbjct: 1118 EAL---KKSL--------NGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPL 1166
Query: 484 QEDVLVREKFKRSM 497
E + ++E F++ +
Sbjct: 1167 AEHLQIKEAFEKEV 1180
Score = 32.0 bits (71), Expect = 1.9
Identities = 79/443 (17%), Positives = 169/443 (38%), Gaps = 68/443 (15%)
Query: 82 RNYLKQPVVKEKEKKKYNVSKISQSKG-QKEISV-----EKKHTWNASLFNSQIHMIAQR 135
RN +KQ + +E K+ I ++K QKE+S+ EKK M Q
Sbjct: 564 RNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG-------RKVTEMEGQA 616
Query: 136 RDAMAHRILSARLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNN 195
++ A LS K + +K+ L++ +
Sbjct: 617 KELSAKLALSIPAEKFENMKSSLSN---------------------------EVNEKAKK 649
Query: 196 LPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQKLSE-DKNL 254
L ++ +H+ + +RQL R+ + + L++ ++ + + +K++ QK E K +
Sbjct: 650 LVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSR----LEQKSGELGKKI 705
Query: 255 AEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQ 314
E L K+ ++K ++ L + + L + + L
Sbjct: 706 TELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLN 765
Query: 315 VEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDY--------PKVSSTKSVQADRKI 366
++ + QK EK E+E + + + K++ E ++ + KS + K
Sbjct: 766 RKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKK 825
Query: 367 LPFTSMRHQGTQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVN-KLPKQE----D 421
+ G + + LT++ + ++ + + E+ +N L K D
Sbjct: 826 QLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLD 885
Query: 422 SKRKYEDLSGE-----EKHLEVQILLENTGRQKDKK-----EDQEKKNIFVKEEQELPPK 471
K+K+ED++ E +K+ ++ LENT Q + E + K + + +++
Sbjct: 886 VKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDS 945
Query: 472 IIEVIHPERESNQEDVLVREKFK 494
E++ R+ +E V + + K
Sbjct: 946 NAEILANYRKGQEEIVTLHAEIK 968
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 58.2 bits (139), Expect = 2e-08
Identities = 90/402 (22%), Positives = 171/402 (42%), Gaps = 76/402 (18%)
Query: 150 KIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQNEVKN 209
++K L+ A+ HK + + Q+Q H K + + + + L + +K QNE+ N
Sbjct: 1239 EVKVLQQVKAESEHKRKKLDA------QVQELHAK-VSEGDRLRVELAEKASKLQNELDN 1291
Query: 210 LRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQ-----------ALQKLSEDKN-LAER 257
+ LL ++++K ++ +SQL T+++LQ +++L E+KN L E+
Sbjct: 1292 VSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQ 1351
Query: 258 EE---------------LTHKLSIITTKMDANDKKIQSLE---KQLRLNCRAFSRQLAIE 299
+E L +L+ K+D + I+SLE K+L + A S++L
Sbjct: 1352 QEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRL--- 1408
Query: 300 TRKTLAAQTATKT----------LQVEVKH-------LQQKLKEKDRELEIKNIYSHRIL 342
K LA KT L V++ H L++K K+ D+ L + S R
Sbjct: 1409 EEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYA 1468
Query: 343 KNLHDTEDYPKVSSTKSVQADRKILPFTSMRHQGTQ-----KSDVPPLTTKGKKATGNID 397
+ E + TK++ R + + + + ++D+ L + N+
Sbjct: 1469 EERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVH 1528
Query: 398 HKEKSTE-INHEIPHCVNKLPKQEDSKRKYEDLSGEEKHLEVQILLENTGRQKD----KK 452
EKS + ++ +L + ED + ED + LEV + ++D +
Sbjct: 1529 ELEKSKRALEQQVEEMRTQLEELEDELQATED---AKLRLEVNMQAMKAQFERDLQTRDE 1585
Query: 453 EDQEKKNIFVKEEQELPPKIIEVIHPERESNQEDVLVREKFK 494
+++EKK + +K+ +EL ++ E E Q + V K K
Sbjct: 1586 QNEEKKRLLIKQVRELEAEL------EDERKQRALAVASKKK 1621
Score = 45.1 bits (105), Expect = 2e-04
Identities = 88/408 (21%), Positives = 167/408 (40%), Gaps = 56/408 (13%)
Query: 200 MAKHQNEVKNLRQLLRKSQEKERTLSRKLRETD---SQLLKTKDILQALQKLSEDKNLAE 256
+ + + E++ + L K +EK+ + +L E + QLL+ K+IL A Q +E + AE
Sbjct: 847 VTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNIL-AEQLQAETELFAE 905
Query: 257 REELT--------------HKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRK 302
EE+ H L + + ++ +Q+ +K+++ + + QL E
Sbjct: 906 AEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEE--- 962
Query: 303 TLAAQTATKTLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQA 362
+ A + LQ+E + K+K+ + E+ + + + +K ED S++ +
Sbjct: 963 ----EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEE 1018
Query: 363 DRKILPFTSMRH-QGTQKSDVPPLTTKGKKATGNIDH-KEKSTEINHEIPHCVNKLPKQE 420
+ K +R+ Q SD+ K +K ++ K K ++ + +L Q
Sbjct: 1019 EEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQI 1078
Query: 421 DSKRKYEDLSGEEKHLEVQILLENTGRQKDKKEDQEKKNIFVKEEQELPPKIIEVIHPER 480
D + L+ +E+ L+ G ++ KN +K +EL +I E + +
Sbjct: 1079 DELKL--QLAKKEEELQ--------GALARGDDETLHKNNALKVVRELQAQIAE-LQEDF 1127
Query: 481 ESNQEDVLVREKFKRSMQ------RNGVDDTLGKGTAPYTKGPLRQRRHYSFTEATENLH 534
ES + EK KR + + ++DTL A + LR +R E + L
Sbjct: 1128 ESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAA---QQELRTKREQEVAELKKALE 1184
Query: 535 HGLPASGGPANAGNMRYSHSTG-KHLSNREEM------ELEHSDSGYE 575
A +MR H+T + LS + E LE + G E
Sbjct: 1185 E--ETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLE 1230
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 57.8 bits (138), Expect = 3e-08
Identities = 94/432 (21%), Positives = 185/432 (42%), Gaps = 63/432 (14%)
Query: 82 RNYLKQPVVKEKEKKKYNVSKISQSKGQKEISVE--KKHTWNASLFNSQIHMIAQRRDAM 139
+N LKQ KE+++ + N++++ QS QK+ +E + A L +++ Q++
Sbjct: 944 QNTLKQNE-KEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQ 1002
Query: 140 AHRILSARLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQI 199
A + L+A KI L+N + + ++ + L + + E + +
Sbjct: 1003 AAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQED 1062
Query: 200 MAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQK---------LSE 250
+ ++N++ N +L+++ + + TL + + + QL + LQ +QK ++E
Sbjct: 1063 LISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNE 1122
Query: 251 DKNLAEREEL----------------THKLSIITTKMDANDKKIQSLEKQLRLNCRAFSR 294
LAE EE+ +HKL I + D K ++++L L +A S
Sbjct: 1123 KSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSL 1182
Query: 295 QLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKV 354
+ A+E K + L+ +VK +++LK++ E E K LH +V
Sbjct: 1183 KAAVEQEK-----RNQQILKDQVKKEEEELKKEFIEKEAK----------LHSEIKEKEV 1227
Query: 355 SSTKSVQADRKI-LPFTSMRHQ-GTQKSDVPPLTTKGKKATGNIDHKEKST-EINHEIPH 411
K + + K+ + T++ GT K + + + + EK T ++ EI
Sbjct: 1228 GMKKHEENEAKLTMQITALNENLGTVKKE-------WQSSQRRVSELEKQTDDLRGEIAV 1280
Query: 412 CVNKLPKQEDSKRKYED--LSGE-------EKHLEVQILLENTGRQKDKKEDQEKKNIFV 462
+ +D +R + L GE K LE+Q L+NT ++ +E +++ +
Sbjct: 1281 LEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNT-TAAVQELGRENQSLQI 1339
Query: 463 KEEQELPPKIIE 474
K Q L K E
Sbjct: 1340 KHTQALNRKWAE 1351
Score = 52.0 bits (123), Expect = 2e-06
Identities = 97/433 (22%), Positives = 182/433 (42%), Gaps = 91/433 (21%)
Query: 101 SKISQSK---GQKEISVEKKHTWNASLFNSQIHMIAQRRDAMAHRILSARLHKIKGLKNE 157
S++++SK Q +I ++ K L +++ AQR D H + +N
Sbjct: 628 SQLNESKEKVSQLDIQIKAK---TELLLSAEAAKTAQRADLQNH---------LDTAQNA 675
Query: 158 LADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQL---L 214
L D +L I T+ L Q+ AK Q++ ++ QL L
Sbjct: 676 LQDKQQELNKITTQ------------------------LDQVTAKLQDKQEHCSQLESHL 711
Query: 215 RKSQEKERTLSRKLRETDSQLLKTK-DIL-------QALQKLSEDKNLAEREELT----- 261
++ +EK +L +K E + Q+ K + D L QALQ L + + L EL
Sbjct: 712 KEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELS 771
Query: 262 -----HKLSIITTKMDANDKKIQSLEK-QLRLNCRAFSRQLAIETRKTLAAQTATKTLQV 315
K + +T++D KK ++LE + +L + +Q+ + +TL+ +T ++
Sbjct: 772 KQLEMEKEIVSSTRLDLQ-KKSEALESIKQKLTKQEEEKQILKQDFETLSQET-----KI 825
Query: 316 EVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKILPFTSMRHQ 375
+ + L +++ EL+ + ++ L +D K+S S+++
Sbjct: 826 QHEELNNRIQTTVTELQKVKMEKEALMTELSTVKD--KLSKVSD-----------SLKNS 872
Query: 376 GTQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIP-HCVNKLPKQEDSKRKYEDLSGEEK 434
KS+ KGK A +D ++ E+ H++ N L +Q++ K+ E +EK
Sbjct: 873 ---KSEFEKENQKGKAAI--LDLEKTCKELKHQLQVQMENTLKEQKELKKSLE----KEK 923
Query: 435 HLEVQILLENTGRQKDKKEDQEKKNIFVKEEQELPPKIIEVIH-PERESNQEDVLVREKF 493
Q+ LE Q+ + Q KEEQ+L I E+ E++ Q + L E
Sbjct: 924 EASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELK 983
Query: 494 KRSMQRNGVDDTL 506
+Q+ +++ L
Sbjct: 984 IAVLQKTELENKL 996
Score = 48.5 bits (114), Expect = 2e-05
Identities = 100/500 (20%), Positives = 195/500 (39%), Gaps = 92/500 (18%)
Query: 43 NASNKSVDYSRSQ--CSCGSLSSQYDYSEDFL----CDCSEKAINRNYLKQPVVKEKEKK 96
+ S K++ + Q C L S+ SE L + SEK LK+ + + + K
Sbjct: 329 SVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKY 388
Query: 97 KYNVSKISQSKGQKEISVEKKHTWNASLFNSQIH---MIAQRRDAMAHRILSARLH---- 149
++ ++ Q + Q+E +++H +Q+H + +R+ AH L +
Sbjct: 389 QHLKAEFKQLQQQRE--EKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSE 446
Query: 150 KIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENS---QNNLPQIMAKHQNE 206
K+ + ++AD+ KL + + QL+ K NS Q+ L + +HQ +
Sbjct: 447 KLMDKEQQVADLQLKLSRL--------EEQLKE-----KVTNSTELQHQLDKTKQQHQEQ 493
Query: 207 VKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAERE-------- 258
+ K +E + L + LR+ + K +++ LQK E+ +L E+E
Sbjct: 494 QALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKI 553
Query: 259 --------------ELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTL 304
E H L T++ K KQ + N Q+ +
Sbjct: 554 QAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQEN---LHDQVQEQKAHLR 610
Query: 305 AAQTATKTLQVEVKHLQQKL---KEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQ 361
AAQ +L+ V L +L KEK +L+I+ +L + ++ + +
Sbjct: 611 AAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAE--------AAKTAQR 662
Query: 362 ADRKILPFTSMRHQGTQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVNKLPKQED 421
AD + T+ ++ ++ +TT+ + T + K++ HC ++
Sbjct: 663 ADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQE---------HCSQLESHLKE 713
Query: 422 SKRKY-------EDLSGEEKHLEVQIL---------LENTGRQKDKKEDQEKKNIFVKEE 465
K KY E+L G+ K LE L L++ +Q+ D E + + ++
Sbjct: 714 YKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQ 773
Query: 466 QELPPKIIEVIHPERESNQE 485
E+ +I+ + + E
Sbjct: 774 LEMEKEIVSSTRLDLQKKSE 793
Score = 37.0 bits (84), Expect = 0.059
Identities = 78/383 (20%), Positives = 162/383 (42%), Gaps = 47/383 (12%)
Query: 157 ELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQLLRK 216
EL + +LE TEN +KQ++ +E L +A +++ R L
Sbjct: 136 ELQSLEQQLEEAQTENFNIKQMK-------DLFEQKAAQLATEIADIKSKYDEERSLREA 188
Query: 217 SQEKERTLSRKLRE--TDSQLLKT---------------KDILQALQKLSEDKNLAEREE 259
+++K L+ +L + T Q LKT K+++Q +Q L ++ L ERE
Sbjct: 189 AEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQ-VQTLMDNMTL-ERER 246
Query: 260 LTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVEVKH 319
+ KL K+ + ++ QLR +++A+ ++ +++ L + +
Sbjct: 247 ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQT 306
Query: 320 LQQKLKEKDRE---LEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKILPFTSMRHQG 376
L + L +K+++ LE K+ KN+ T + K + +Q+ R TS+
Sbjct: 307 LTENLLKKEQDYTKLEEKHNEESVSKKNIQATL-HQKDLDCQQLQS-RLSASETSLHRIH 364
Query: 377 TQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVNKLPKQEDSKRKYE-DLSGEEKH 435
+ S+ T K K+ ++ K + + + +L +Q + K ++ L E
Sbjct: 365 VELSEKGEATQKLKEELSEVETKYQHLKAEFK------QLQQQREEKEQHGLQLQSEINQ 418
Query: 436 LEVQILL------ENTGRQKDKKEDQEKKNIFVKEEQ--ELPPKIIEVIHPERESNQEDV 487
L ++L E GR K++++ +K + KE+Q +L K+ + +E
Sbjct: 419 LHSKLLETERQLGEAHGRLKEQRQLSSEK-LMDKEQQVADLQLKLSRLEEQLKEKVTNST 477
Query: 488 LVREKFKRSMQRNGVDDTLGKGT 510
++ + ++ Q++ L + T
Sbjct: 478 ELQHQLDKTKQQHQEQQALQQST 500
>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
theta, 150/170kDa [Homo sapiens]
Length = 1382
Score = 56.6 bits (135), Expect = 7e-08
Identities = 80/423 (18%), Positives = 180/423 (42%), Gaps = 48/423 (11%)
Query: 111 EISVEKKHTWNASLFNSQIHMIAQRRDAMAHRILSARLHKIKGLKNELADMHHKLEAILT 170
++ V HT F S ++ + + + S +I+ ++ + K ++
Sbjct: 479 DLQVRIDHTSRTLSFGSDLNYATREDAPIGPHLQSMPSEQIRNQLTAMSSVLAKALEVIK 538
Query: 171 ENQFLKQLQLRHLKAIGKY-ENSQNNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLR 229
L++ + +H A+ Y +NS+ +I+A+ Q + KER S ++
Sbjct: 539 PAHILQEKEEQHQLAVTAYLKNSRKEHQRILARRQTI----------EERKERLESLNIQ 588
Query: 230 ETDSQLLKTKDILQALQKLSEDKNLAEREELTHKLSIITTKMDANDKKIQSLEKQLR--- 286
+L + + LQ ++K E++ E +E K I+ K ++ +Q++
Sbjct: 589 REKEELEQREAELQKVRKAEEERLRQEAKE-REKERILQEHEQIKKKTVRERLEQIKKTE 647
Query: 287 LNCRAFSRQLAIETRKTLAAQ----TATKTLQVEVKHLQQKLKEKDRELE---------- 332
L +AF + + IE + L + L+ E K LQ++LK ++++++
Sbjct: 648 LGAKAF-KDIDIEDLEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKIDYFERAKRLEE 706
Query: 333 ---IKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKILPFTSMRHQGTQKSDVPPLTTKG 389
IK+ Y + +K++ E + T K L + + + D+ + K
Sbjct: 707 IPLIKSAYEEQRIKDMDLWEQQEEERITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKA 766
Query: 390 KKATGNIDHKEKSTEINHEIPHCVNKLPKQEDSKRK-------YEDLSGEEKHLEVQILL 442
+ + + ++ E E H N+L +++ +++ E E++ E Q+L
Sbjct: 767 ARQSVYEEKLKQFEERLAEERH--NRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLK 824
Query: 443 ENTGRQKDKKEDQEKKNIFVKEEQELPPKIIEVIHPERESNQEDVLVREKFKRSMQRNGV 502
E R++ ++ +E++ ++E QE K+ EV ER+ Q ++ + E+ +R + +
Sbjct: 825 EREERERAERAKREEE---LREYQERVKKLEEV---ERKKRQRELEIEERERRREEERRL 878
Query: 503 DDT 505
D+
Sbjct: 879 GDS 881
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 56.6 bits (135), Expect = 7e-08
Identities = 93/435 (21%), Positives = 187/435 (42%), Gaps = 75/435 (17%)
Query: 103 ISQSKGQKEISVEKKHTWNASLFNSQIHMIAQRRDAMAHRILSARLHKIKGLKNELADMH 162
+S S+ +KE+ E KH + + ++ M+ + ++A+ R+ ++ +++ L+ +L H
Sbjct: 576 VSASESRKEL--ELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSH 633
Query: 163 HKLEAILTENQFLKQLQLRHLKAIGKYENSQN-NLPQIMAKHQNEVKNLRQLLRKSQEKE 221
+ + L E+ L++ H I K +++ + Q + QNE+ Q + Q ++
Sbjct: 634 EEELSKLKED-----LEIEHRINIEKLKDNLGIHYKQQIDGLQNEMS---QKIETMQFEK 685
Query: 222 RTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAEREELTHKLSIITTKMDANDKKIQSL 281
L K + ++ K KD+ Q+L ++ + EL ++ I+ + +K+ +L
Sbjct: 686 DNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQE----EKEKGTL 741
Query: 282 EKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKDRELEIKNIYSHRI 341
E++++ Q T+ L+ ++K + L+EK +LE +N I
Sbjct: 742 EQEVQ------------------ELQLKTELLEKQMKEKENDLQEKFAQLEAEN----SI 779
Query: 342 LKNLHDT-EDYPKVSSTKSVQADRKILPFTSMRHQGTQ-----------------KSDVP 383
LK+ T ED K+ + V + +++ S++ + K
Sbjct: 780 LKDEKKTLEDMLKIHT--PVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCI 837
Query: 384 PLTTKGKKATGNIDHKEKSTEINH----EIPHCVNKLPKQ-EDSKRKYE-----DLSGEE 433
L + +K EK+ E+N+ E C+ K+ EDSK K E L
Sbjct: 838 QLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALN 897
Query: 434 KHLEVQILLENTGRQKDKKEDQEKKNIFVKEEQELPPKIIEVIHPERESNQE--DVLVRE 491
+ L +Q + T + K D++K FV E E+ EV+ + E +V RE
Sbjct: 898 EELHLQRINPTTVKMKSSVFDEDK--TFVAETLEMG----EVVEKDTTELMEKLEVTKRE 951
Query: 492 KFKRSMQRNGVDDTL 506
K + S + + + + L
Sbjct: 952 KLELSQRLSDLSEQL 966
Score = 40.8 bits (94), Expect = 0.004
Identities = 66/343 (19%), Positives = 137/343 (39%), Gaps = 48/343 (13%)
Query: 154 LKNELADMHHKLEAILTENQFLKQL------QLRHLKAIGKYEN-SQNNLPQIMAKHQNE 206
L E + H+L+ ++ E L+Q ++ +K + K N N L Q + + E
Sbjct: 2377 LSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRE 2436
Query: 207 VKNLRQLLRKSQEKERTLSRKLRETDSQL--LKTKDILQALQKLSEDKNLAEREE----- 259
+++ ++ + L + +L + T+D L++L+ + K+ E +
Sbjct: 2437 RESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIIN 2496
Query: 260 LTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVEVKH 319
L +L + + + A D ++ KQ++ Q T+ LQ ++ +
Sbjct: 2497 LETRLLQLESTVSAKDLELTQCYKQIK--------------DMQEQGQFETEMLQKKIVN 2542
Query: 320 LQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKILPFTSMRHQGTQK 379
LQ+ ++EK + I + + +D +SS + +R + + +
Sbjct: 2543 LQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISS----EPERTNIQNLNQLREDELG 2598
Query: 380 SDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVNKLPKQEDSKRKYEDLSGEEKHLEVQ 439
SD+ LT + + + S + E K L E+K LE+Q
Sbjct: 2599 SDISALTLRISELESQVVEMHTSLILEKEQVEIAEK-----------NVLEKEKKLLELQ 2647
Query: 440 ILLENTGRQKDKKEDQEKKNIFVKEEQELPPKIIEVIHPERES 482
LLE G +K ++E ++K++ ++ E+ E+ H ES
Sbjct: 2648 KLLE--GNEKKQREKEKKRS---PQDVEVLKTTTELFHSNEES 2685
Score = 38.5 bits (88), Expect = 0.020
Identities = 94/465 (20%), Positives = 173/465 (37%), Gaps = 60/465 (12%)
Query: 40 RNSNASNKSVDYSRSQCSCGSLSSQYDYSEDFLCDCSEKAINRNYLKQPVVKEKEKKKYN 99
RNS S+ + D +++ + Q + + L D +K ++ Q +++ K Y
Sbjct: 252 RNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKK--KEDFTMQISFLQEKIKVYE 309
Query: 100 VSKISQSKGQKEISVEKKHTWNASLFNSQIHMIAQRRDAMAHRILSARLHKIKGLKNELA 159
+ + + + + +++K T L N++I I + + + L +L L EL
Sbjct: 310 MEQDKKVENSNKEEIQEKETIIEEL-NTKI--IEEEKKTLE---LKDKLTTADKLLGELQ 363
Query: 160 DMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMA--------KHQNEVKNLR 211
E I+ +NQ +K ++L + K S + Q+M H++
Sbjct: 364 ------EQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETD 417
Query: 212 QLLRKSQEKERTLSRKLRETDSQL------LKTKDILQALQKLSEDK--NLAEREELTHK 263
+ R QE +R L + E D +K + I Q + ++ E K + E E
Sbjct: 418 IVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRS 477
Query: 264 LSIITTKMD--------ANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQV 315
S IT D N+ I+ + + L +E + L Q ++
Sbjct: 478 YSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEEL 537
Query: 316 EVKHLQ-QKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKILPFTSMRH 374
Q Q+ ++ E E K +H+ L + D + + S RK L ++H
Sbjct: 538 SFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLK-----AEIVSASESRKEL---ELKH 589
Query: 375 QGTQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVNKLPKQEDSKRKYEDLSGEEK 434
+ + L K+ +D +S E E +E+ + EDL E +
Sbjct: 590 EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHR 649
Query: 435 ------------HLEVQI-LLENTGRQKDKKEDQEKKNIFVKEEQ 466
H + QI L+N QK + EK N+ K+ Q
Sbjct: 650 INIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQ 694
Score = 33.9 bits (76), Expect = 0.50
Identities = 80/429 (18%), Positives = 159/429 (37%), Gaps = 83/429 (19%)
Query: 42 SNASNKSVDYSRSQCSCGSLSSQYDYSEDFLCDCSEKAINRNYLKQPVVKEKEKKKYNVS 101
S S K ++ ++ + Q + + L +K +N Q +V+EK VS
Sbjct: 2506 STVSAKDLELTQCYKQIKDMQEQGQFETEML---QKKIVNL----QKIVEEKVAAAL-VS 2557
Query: 102 KISQSKGQKEISV-EKKHTWNASLFNSQIHMIAQRRDAMAHRILSARLHKIKGLKNELAD 160
+I Q+ + T ++ + I + Q R+ +SA +I L++++ +
Sbjct: 2558 QIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVE 2617
Query: 161 MHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQEK 220
MH L IL + Q E ++ N+ + + ++ L++LL +++K
Sbjct: 2618 MHTSL--ILEKEQV---------------EIAEKNV----LEKEKKLLELQKLLEGNEKK 2656
Query: 221 ERTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAEREELTHKLSIITTKMDANDKKIQS 280
+R +K D ++LKT + E E E L + ++ + +K +
Sbjct: 2657 QREKEKKRSPQDVEVLKT--TTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEK 2714
Query: 281 LEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKDRELEIKNIYSHR 340
L+++L L +T +LQ ++ ++ L E +L I
Sbjct: 2715 LQEEL------------------LVKETNMTSLQKDLSQVRDHLAEAKEKLSIL------ 2750
Query: 341 ILKNLHDTEDYPKVSSTKS--------VQADRKILPFTSMRHQGTQKSDVPPLTTKGKKA 392
+ ED +V +K ++ + I T + + + P + K
Sbjct: 2751 ------EKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI 2804
Query: 393 TGNIDHKEKSTEINHEIPHCVNKLPKQEDSKRKYEDLSGEEKHLE------------VQI 440
N+ + S E+ I K+ K ++ E L E +H+ VQ+
Sbjct: 2805 QINLQSECSSEEVTEIISQFTEKIEKMQE-LHAAEILDMESRHISETETLKREHYVAVQL 2863
Query: 441 LLENTGRQK 449
L E G K
Sbjct: 2864 LKEECGTLK 2872
Score = 32.3 bits (72), Expect = 1.5
Identities = 44/225 (19%), Positives = 96/225 (42%), Gaps = 24/225 (10%)
Query: 210 LRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAEREELTHKLSIITT 269
L++L ++ +EK + L ET+ L D LQ Q++ +D+ + + + T
Sbjct: 3345 LKELQKQLEEKHSRIVELLNETEKYKL---DSLQTRQQMEKDRQVHRK--------TLQT 3393
Query: 270 KMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKDR 329
+ +AN + Q +L+ RQL + ++ + LQ ++ Q++ E++
Sbjct: 3394 EQEANTEG-QKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREE 3452
Query: 330 ELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKILPFTSMRHQG-TQKSDVPPLTTK 388
+ E + I + +NL++ +T S+ +DR + +G T++S+ L
Sbjct: 3453 KRESRRI----LYQNLNE-------PTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEM 3501
Query: 389 GKKATGNIDHKEKSTEINHEIPHCVNKLPKQEDSKRKYEDLSGEE 433
TG E + + + LP++ + ++E E+
Sbjct: 3502 NGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDED 3546
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 56.6 bits (135), Expect = 7e-08
Identities = 93/435 (21%), Positives = 187/435 (42%), Gaps = 75/435 (17%)
Query: 103 ISQSKGQKEISVEKKHTWNASLFNSQIHMIAQRRDAMAHRILSARLHKIKGLKNELADMH 162
+S S+ +KE+ E KH + + ++ M+ + ++A+ R+ ++ +++ L+ +L H
Sbjct: 576 VSASESRKEL--ELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSH 633
Query: 163 HKLEAILTENQFLKQLQLRHLKAIGKYENSQN-NLPQIMAKHQNEVKNLRQLLRKSQEKE 221
+ + L E+ L++ H I K +++ + Q + QNE+ Q + Q ++
Sbjct: 634 EEELSKLKED-----LEIEHRINIEKLKDNLGIHYKQQIDGLQNEMS---QKIETMQFEK 685
Query: 222 RTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAEREELTHKLSIITTKMDANDKKIQSL 281
L K + ++ K KD+ Q+L ++ + EL ++ I+ + +K+ +L
Sbjct: 686 DNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQE----EKEKGTL 741
Query: 282 EKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKDRELEIKNIYSHRI 341
E++++ Q T+ L+ ++K + L+EK +LE +N I
Sbjct: 742 EQEVQ------------------ELQLKTELLEKQMKEKENDLQEKFAQLEAEN----SI 779
Query: 342 LKNLHDT-EDYPKVSSTKSVQADRKILPFTSMRHQGTQ-----------------KSDVP 383
LK+ T ED K+ + V + +++ S++ + K
Sbjct: 780 LKDEKKTLEDMLKIHT--PVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCI 837
Query: 384 PLTTKGKKATGNIDHKEKSTEINH----EIPHCVNKLPKQ-EDSKRKYE-----DLSGEE 433
L + +K EK+ E+N+ E C+ K+ EDSK K E L
Sbjct: 838 QLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALN 897
Query: 434 KHLEVQILLENTGRQKDKKEDQEKKNIFVKEEQELPPKIIEVIHPERESNQE--DVLVRE 491
+ L +Q + T + K D++K FV E E+ EV+ + E +V RE
Sbjct: 898 EELHLQRINPTTVKMKSSVFDEDK--TFVAETLEMG----EVVEKDTTELMEKLEVTKRE 951
Query: 492 KFKRSMQRNGVDDTL 506
K + S + + + + L
Sbjct: 952 KLELSQRLSDLSEQL 966
Score = 40.8 bits (94), Expect = 0.004
Identities = 66/343 (19%), Positives = 137/343 (39%), Gaps = 48/343 (13%)
Query: 154 LKNELADMHHKLEAILTENQFLKQL------QLRHLKAIGKYEN-SQNNLPQIMAKHQNE 206
L E + H+L+ ++ E L+Q ++ +K + K N N L Q + + E
Sbjct: 2369 LSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRE 2428
Query: 207 VKNLRQLLRKSQEKERTLSRKLRETDSQL--LKTKDILQALQKLSEDKNLAEREE----- 259
+++ ++ + L + +L + T+D L++L+ + K+ E +
Sbjct: 2429 RESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIIN 2488
Query: 260 LTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVEVKH 319
L +L + + + A D ++ KQ++ Q T+ LQ ++ +
Sbjct: 2489 LETRLLQLESTVSAKDLELTQCYKQIK--------------DMQEQGQFETEMLQKKIVN 2534
Query: 320 LQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKILPFTSMRHQGTQK 379
LQ+ ++EK + I + + +D +SS + +R + + +
Sbjct: 2535 LQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISS----EPERTNIQNLNQLREDELG 2590
Query: 380 SDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVNKLPKQEDSKRKYEDLSGEEKHLEVQ 439
SD+ LT + + + S + E K L E+K LE+Q
Sbjct: 2591 SDISALTLRISELESQVVEMHTSLILEKEQVEIAEK-----------NVLEKEKKLLELQ 2639
Query: 440 ILLENTGRQKDKKEDQEKKNIFVKEEQELPPKIIEVIHPERES 482
LLE G +K ++E ++K++ ++ E+ E+ H ES
Sbjct: 2640 KLLE--GNEKKQREKEKKRS---PQDVEVLKTTTELFHSNEES 2677
Score = 38.5 bits (88), Expect = 0.020
Identities = 94/465 (20%), Positives = 173/465 (37%), Gaps = 60/465 (12%)
Query: 40 RNSNASNKSVDYSRSQCSCGSLSSQYDYSEDFLCDCSEKAINRNYLKQPVVKEKEKKKYN 99
RNS S+ + D +++ + Q + + L D +K ++ Q +++ K Y
Sbjct: 252 RNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKK--KEDFTMQISFLQEKIKVYE 309
Query: 100 VSKISQSKGQKEISVEKKHTWNASLFNSQIHMIAQRRDAMAHRILSARLHKIKGLKNELA 159
+ + + + + +++K T L N++I I + + + L +L L EL
Sbjct: 310 MEQDKKVENSNKEEIQEKETIIEEL-NTKI--IEEEKKTLE---LKDKLTTADKLLGELQ 363
Query: 160 DMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMA--------KHQNEVKNLR 211
E I+ +NQ +K ++L + K S + Q+M H++
Sbjct: 364 ------EQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETD 417
Query: 212 QLLRKSQEKERTLSRKLRETDSQL------LKTKDILQALQKLSEDK--NLAEREELTHK 263
+ R QE +R L + E D +K + I Q + ++ E K + E E
Sbjct: 418 IVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRS 477
Query: 264 LSIITTKMD--------ANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQV 315
S IT D N+ I+ + + L +E + L Q ++
Sbjct: 478 YSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEEL 537
Query: 316 EVKHLQ-QKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKILPFTSMRH 374
Q Q+ ++ E E K +H+ L + D + + S RK L ++H
Sbjct: 538 SFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLK-----AEIVSASESRKEL---ELKH 589
Query: 375 QGTQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVNKLPKQEDSKRKYEDLSGEEK 434
+ + L K+ +D +S E E +E+ + EDL E +
Sbjct: 590 EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHR 649
Query: 435 ------------HLEVQI-LLENTGRQKDKKEDQEKKNIFVKEEQ 466
H + QI L+N QK + EK N+ K+ Q
Sbjct: 650 INIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQ 694
Score = 33.9 bits (76), Expect = 0.50
Identities = 80/429 (18%), Positives = 159/429 (37%), Gaps = 83/429 (19%)
Query: 42 SNASNKSVDYSRSQCSCGSLSSQYDYSEDFLCDCSEKAINRNYLKQPVVKEKEKKKYNVS 101
S S K ++ ++ + Q + + L +K +N Q +V+EK VS
Sbjct: 2498 STVSAKDLELTQCYKQIKDMQEQGQFETEML---QKKIVNL----QKIVEEKVAAAL-VS 2549
Query: 102 KISQSKGQKEISV-EKKHTWNASLFNSQIHMIAQRRDAMAHRILSARLHKIKGLKNELAD 160
+I Q+ + T ++ + I + Q R+ +SA +I L++++ +
Sbjct: 2550 QIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVE 2609
Query: 161 MHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQEK 220
MH L IL + Q E ++ N+ + + ++ L++LL +++K
Sbjct: 2610 MHTSL--ILEKEQV---------------EIAEKNV----LEKEKKLLELQKLLEGNEKK 2648
Query: 221 ERTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAEREELTHKLSIITTKMDANDKKIQS 280
+R +K D ++LKT + E E E L + ++ + +K +
Sbjct: 2649 QREKEKKRSPQDVEVLKT--TTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEK 2706
Query: 281 LEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKDRELEIKNIYSHR 340
L+++L L +T +LQ ++ ++ L E +L I
Sbjct: 2707 LQEEL------------------LVKETNMTSLQKDLSQVRDHLAEAKEKLSIL------ 2742
Query: 341 ILKNLHDTEDYPKVSSTKS--------VQADRKILPFTSMRHQGTQKSDVPPLTTKGKKA 392
+ ED +V +K ++ + I T + + + P + K
Sbjct: 2743 ------EKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI 2796
Query: 393 TGNIDHKEKSTEINHEIPHCVNKLPKQEDSKRKYEDLSGEEKHLE------------VQI 440
N+ + S E+ I K+ K ++ E L E +H+ VQ+
Sbjct: 2797 QINLQSECSSEEVTEIISQFTEKIEKMQE-LHAAEILDMESRHISETETLKREHYVAVQL 2855
Query: 441 LLENTGRQK 449
L E G K
Sbjct: 2856 LKEECGTLK 2864
Score = 32.3 bits (72), Expect = 1.5
Identities = 44/225 (19%), Positives = 96/225 (42%), Gaps = 24/225 (10%)
Query: 210 LRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAEREELTHKLSIITT 269
L++L ++ +EK + L ET+ L D LQ Q++ +D+ + + + T
Sbjct: 3337 LKELQKQLEEKHSRIVELLNETEKYKL---DSLQTRQQMEKDRQVHRK--------TLQT 3385
Query: 270 KMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKDR 329
+ +AN + Q +L+ RQL + ++ + LQ ++ Q++ E++
Sbjct: 3386 EQEANTEG-QKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREE 3444
Query: 330 ELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKILPFTSMRHQG-TQKSDVPPLTTK 388
+ E + I + +NL++ +T S+ +DR + +G T++S+ L
Sbjct: 3445 KRESRRI----LYQNLNE-------PTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEM 3493
Query: 389 GKKATGNIDHKEKSTEINHEIPHCVNKLPKQEDSKRKYEDLSGEE 433
TG E + + + LP++ + ++E E+
Sbjct: 3494 NGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDED 3538
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 56.6 bits (135), Expect = 7e-08
Identities = 75/394 (19%), Positives = 164/394 (41%), Gaps = 35/394 (8%)
Query: 121 NASLFNSQIHMIAQRRDAMAHRILSARLH---KIKGLKNELADMHHKLEAILTENQFLKQ 177
N + +++ M+ R ++L+ R H + + L + + D+ + + + L+Q
Sbjct: 428 NNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQ 487
Query: 178 LQLRH-LKAIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLL 236
H + + + + L + A Q + + L L ++++EK+ L++ L++ +
Sbjct: 488 ASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQ 547
Query: 237 KTKDILQAL-----QKLSEDKNLAEREELT---HKLSIITT---------KMDANDKKIQ 279
+ ++ L QK + K +AE++E T H + T + DA K+++
Sbjct: 548 GLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLE 607
Query: 280 SLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKDRELEIKNIYSH 339
+LEK+ +QL + +AQT+ Q E L +K++E +E H
Sbjct: 608 ALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQH 667
Query: 340 RILKNLHDTEDYPKVSSTKSVQADRKILPFTSMRHQGTQKSDVPPLTTKGKKATGNI-DH 398
+ + E + K+ + +R ++ Q + L K G++ +
Sbjct: 668 EAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQ------LQALKESLKVTKGSLEEE 721
Query: 399 KEKSTEINHEIPHCVNKLPKQEDSKRKYEDLSGEEKHLEVQILLENTGRQKDKKEDQEKK 458
K ++ + E C+++L + +++ E E K LE E GR+ + Q+
Sbjct: 722 KRRAADALEEQQRCISEL--KAETRSLVEQHKRERKELEE----ERAGRKGLEARLQQLG 775
Query: 459 NIFVKEEQELPPKIIEVIHPERESNQE-DVLVRE 491
E + L ++ E + + + E + LV+E
Sbjct: 776 EAHQAETEVLRRELAEAMAAQHTAESECEQLVKE 809
Score = 44.7 bits (104), Expect = 3e-04
Identities = 84/412 (20%), Positives = 170/412 (41%), Gaps = 66/412 (16%)
Query: 91 KEKEKKKYNVSKISQSKGQKEISVEKKHTWNASL-------FNSQIHMIAQRRDAMAHRI 143
+E+ +++ V++++Q +G+ + + + A L N Q A ++A+AH +
Sbjct: 997 EERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHAL 1056
Query: 144 LSAR-----LHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLK----------AIGK 188
L K++GL E A + E T Q +QL + + A G+
Sbjct: 1057 TEKEGKDQELAKLRGL--EAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGR 1114
Query: 189 YENSQNNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQKL 248
E + L + A EV L Q +K QE+ +L R L + + L+ LQ
Sbjct: 1115 TEPTGPKLEALRA----EVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQ 1170
Query: 249 SEDKNLAEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRA---FSRQLAIETRKTLA 305
E+K +EL H S + + +++ + +++ + +A + Q+A ++
Sbjct: 1171 LEEK----AQELGHSQSALASA----QRELAAFRTKVQDHSKAEDEWKAQVARGRQEAER 1222
Query: 306 AQTATKTLQVEVKHLQQKLKEKDRE-LEIKNIYSHRILKNLHDTEDYPKVSS-TKSVQAD 363
+ +L+ EV L +++ EK+ E E+K + + ++E K+ + +QA+
Sbjct: 1223 KNSLISSLEEEVSILNRQVLEKEGESKELKRLV-------MAESEKSQKLEERLRLLQAE 1275
Query: 364 RKILPFTSMRHQGTQKSDVPPLTTKGKK---ATGNI-----DHKEKSTEINHEIPHCVNK 415
+ + +V L + +K A+ N+ E++ E+ E+ K
Sbjct: 1276 TASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEK 1335
Query: 416 LPKQED--SKRKYEDLSGE--------EKHLEVQILLENTGRQKDKKEDQEK 457
++E S + E S + KHL Q+ E +K +E+ E+
Sbjct: 1336 FFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQ 1387
Score = 42.0 bits (97), Expect = 0.002
Identities = 76/377 (20%), Positives = 150/377 (39%), Gaps = 50/377 (13%)
Query: 86 KQPVVKEKEKKKYNVSKISQSKGQKEISVEKKHTWNASLFNSQIHMIAQRRDAMAHRILS 145
KQ V E +++ SQ++ +E+ E K W F Q+ A++ L
Sbjct: 1303 KQRVASENLRQELT----SQAERAEELGQELK-AWQEKFF--------QKEQALS--TLQ 1347
Query: 146 ARLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQN 205
+ L +EL H + + E ++ RH + + + + + L + + Q
Sbjct: 1348 LEHTSTQALVSELLPAKHLCQQLQAEQAAAEK---RHREELEQSKQAAGGLRAELLRAQR 1404
Query: 206 EVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQKL--SEDKNLAEREELTHK 263
E+ L L +K E+ERT +++LR + + +L+ L E++ L ER L +
Sbjct: 1405 ELGELIPLRQKVAEQERT-AQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQ 1463
Query: 264 LSIITTKMD-ANDKKIQSLE----------KQLRLNCRAFSRQLAIETRKTLAAQTATKT 312
+ ++D A +K +Q L +++ ++ +R+L + T K A+
Sbjct: 1464 --FLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLE 1521
Query: 313 LQVEVKHLQQKLKEKDRELEI----KNIYSHRILKNLHDTEDYPKVSSTK---------- 358
+ + +QKL + +LE+ + + K L D++ KV K
Sbjct: 1522 ERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGE 1581
Query: 359 -SVQADRKILPFTSMRHQGTQKSDVPP-LTTKGKKATGNIDHKEKSTEINHEIPHCVNKL 416
+A R ++ Q +QK + +KA + D K++ + E + +L
Sbjct: 1582 SQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQL 1641
Query: 417 PKQEDSKRKYEDLSGEE 433
K+ R + G E
Sbjct: 1642 QKENKELRAEAERLGHE 1658
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 56.6 bits (135), Expect = 7e-08
Identities = 83/426 (19%), Positives = 181/426 (42%), Gaps = 43/426 (10%)
Query: 86 KQPVVKEKEKKKYNVSKISQSKGQKEISVEKK-----HTWNASLFNSQIHMIAQRRDAMA 140
KQ V++EK + + ++ +S +++ EK+ A L ++Q+ + + A +
Sbjct: 1622 KQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPS 1681
Query: 141 HRILSARLHKIKGLKNELADMHHKLEAILTENQFLK-QLQLRHLKAIGKYENSQNNLPQI 199
R +I LKN+L + A + + ++ +++ HL+ I ++ L +
Sbjct: 1682 KR-------EIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQ-IDDIAKAKTALEEQ 1733
Query: 200 MAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAEREE 259
+++ Q E ++ L + QE L +K + +Q + + LQ E+ N E++E
Sbjct: 1734 LSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEAN-KEKQE 1792
Query: 260 LTHKLSIITTKMDANDKKI--QSLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVEV 317
L KL + ++++ ++ + +SL + R +L E + ++ L+
Sbjct: 1793 LQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLK--- 1849
Query: 318 KHLQQKLKEKDRELEIKN---IYSHRILKNLHDTEDYPKVSSTKSVQADRK------ILP 368
+++++ +E+D+ + +N + R+ + L DT++ + K +A RK L
Sbjct: 1850 ENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLE 1909
Query: 369 FTSMRHQGTQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVNKLPKQEDSKRKYED 428
+Q Q +D+ + I+ + +S E I + + K + K K E
Sbjct: 1910 SLEAANQSLQ-ADLKLAFKRIGDLQAAIEDEMESDENEDLINSLQDMVTKYQKRKNKLEG 1968
Query: 429 LSGEEKHLEVQI------LLENTGRQKDKKEDQEKKNIFVKEEQELPPKIIEVIHPERES 482
S + LE ++ L +N G K +D K+ P + + P+R
Sbjct: 1969 DSDVDSELEDRVDGVKSWLSKNKGPSKAASDDGSLKS-------SSPTSYWKSLAPDRSD 2021
Query: 483 NQEDVL 488
++ D L
Sbjct: 2022 DEHDPL 2027
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 56.2 bits (134), Expect = 9e-08
Identities = 74/329 (22%), Positives = 139/329 (42%), Gaps = 44/329 (13%)
Query: 145 SARLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQ 204
SA + K + +LA + KL + TE L K + + E + ++ + H+
Sbjct: 808 SATHEQTKAYEEQLAQLQQKLLDLETERILLT-------KQVAEVEAQKKDVCTELDAHK 860
Query: 205 NEVKNLRQLLRKS----QEKERTLSR----KLRETDSQLLKTKDILQALQKLSEDKNLAE 256
+V++L Q L K ++K ++L++ KL + + + +TK IL E+ L
Sbjct: 861 IQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVE----KENMILQM 916
Query: 257 REELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVE 316
RE ++ I+T K+ A + I L ++ +T K + +
Sbjct: 917 REGQKKEIEILTQKLSAKEDSIHILNEEY---------------------ETKFKNQEKK 955
Query: 317 VKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKILPFTSMRHQG 376
++ ++QK KE L+ K + LK + E+ S K Q + K+L G
Sbjct: 956 MEKVKQKAKEMQETLKKKLLDQEAKLKK--ELENTALELSQKEKQFNAKMLEMAQANSAG 1013
Query: 377 TQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVNKLPKQEDSKRKYEDLSGEEKHL 436
+ V L T K+ ++ + E+N I KL +Q + ++ ++ +EK
Sbjct: 1014 ISDA-VSRLETNQKEQIESLTEVHRR-ELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQ 1071
Query: 437 EVQILLENTGRQKDKKEDQEKKNIFVKEE 465
EV L + +KE+ K+ ++KEE
Sbjct: 1072 EVAELKQKILLFGCEKEEMNKEITWLKEE 1100
Score = 55.8 bits (133), Expect = 1e-07
Identities = 83/445 (18%), Positives = 191/445 (42%), Gaps = 38/445 (8%)
Query: 41 NSNASNKSVDYSRSQCSCGSLSSQYDYSEDFLCDCSEKAINRNYLKQPVVKEKEKKKYNV 100
N + +KS+++ + LS + D C +E + + + K +
Sbjct: 1196 NKSLEDKSLEFKK-------LSEELAIQLDICCKKTEALLEAK-TNELINISSSKTNAIL 1247
Query: 101 SKISQSKGQ----KEISVEKKHTWNASLFNSQIHMIAQRRDAMAHRILSARLHKIKGLKN 156
S+IS + + KE + K T S +Q+ + + ++ + A H+++ +N
Sbjct: 1248 SRISHCQHRTTKVKEALLIK--TCTVSELEAQLRQLTEEQNTLNISFQQAT-HQLEEKEN 1304
Query: 157 ELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQLLRK 216
++ M +E+++TE + L++ +A + E+ L + ++++ N V +++ L++
Sbjct: 1305 QIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKE 1364
Query: 217 SQEKERTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAERE--ELTHKLSIITTKMDAN 274
+ + +LS++L + + QL + + + +S + + E EL ++ ++ K+D
Sbjct: 1365 KKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTL 1424
Query: 275 DKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKDRELEIK 334
K+ S +Q+ FS + Q K LQ++++ ++ EKD ++ +
Sbjct: 1425 SKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLL 1484
Query: 335 NIYSHRILKNL--------HDTEDYPKVSSTKSVQADRKILPFTSMRHQGTQKS-DVPPL 385
+ K D K S + + + TQK+ ++ L
Sbjct: 1485 KEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESL 1544
Query: 386 --TTKGKKATGNIDHKEKSTEINHEIPHCVNKLPKQEDSKRKYEDLSGEEKHLEVQILLE 443
K +I+HKE ++ H +L +++D++ K EEK L ++ +
Sbjct: 1545 NEVLKNYNQQKDIEHKELVQKLQH-----FQELGEEKDNRVK----EAEEKILTLENQVY 1595
Query: 444 NTGRQ-KDKKEDQEKKNIFVKEEQE 467
+ + + KK++ E N+ VK ++E
Sbjct: 1596 SMKAELETKKKELEHVNLSVKSKEE 1620
Score = 51.6 bits (122), Expect = 2e-06
Identities = 103/497 (20%), Positives = 201/497 (40%), Gaps = 109/497 (21%)
Query: 82 RNYLKQPVVKEKE--KKKYNVSKISQSKGQKEISVEKKHTWNASLFNSQIHMIAQRRDAM 139
+NY +Q ++ KE +K + ++ + K + E+K + S + ++ +
Sbjct: 1549 KNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKEL 1608
Query: 140 AHRILSARLHKIKGLKNELADMHHKLE----AILTENQFLKQLQLRHLKAIGKYENSQNN 195
H LS +K + EL + +LE A L E LK+ + + AI K SQ
Sbjct: 1609 EHVNLS-----VKSKEEELKALEDRLESESAAKLAE---LKRKAEQKIAAIKKQLLSQME 1660
Query: 196 LPQIMAKHQNEVKNLRQLLRKSQEKERT---LSRKLRETDSQLLKT-------KDILQAL 245
+ K E +L +L K QE+ER L KL+ +S +T K++
Sbjct: 1661 EKEEQYKKGTE-SHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYT 1719
Query: 246 QKLSEDKNLAEREELTHKLSIITTKMDANDKKIQ--------SLEKQLRLNCRAFSRQLA 297
++ D ++ K+S++ + +K +Q ++ + C+ R +
Sbjct: 1720 EQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIK 1779
Query: 298 IETRKTLAAQTATKTLQVEVKHLQQKLKEKDRELEI------------KNIYSHRILKNL 345
+E A+ Q + HLQ++L+EK+++ + NI + + L+N+
Sbjct: 1780 LEH-----AEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENV 1834
Query: 346 HDTEDYPKVSSTKSVQA---DRKILPFTS--MRHQGTQKSDVPPLTTKGKK--ATGNIDH 398
D D K K + ++KI S +R + + ++ LT+K +K A +D
Sbjct: 1835 FD--DVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDG 1892
Query: 399 KEKSTEINHEI-----------PHCVNKLPKQED--------SKRKYEDLSGE------- 432
+ K TE+ E P ++ + Q + ++R+ + L E
Sbjct: 1893 RNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKD 1952
Query: 433 ------EKHLEVQILLENTGRQKDKKEDQEKKNIFVK------------------EEQEL 468
E E++IL + +++++K QE++++ +K +EQEL
Sbjct: 1953 LRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQEL 2012
Query: 469 PPKIIEVIHPERESNQE 485
I E I+ +E E
Sbjct: 2013 EMTIKETINKAQEVEAE 2029
Score = 45.1 bits (105), Expect = 2e-04
Identities = 68/299 (22%), Positives = 123/299 (41%), Gaps = 32/299 (10%)
Query: 204 QNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAER---EEL 260
Q ++ L+ L + + K L+ KL+ TD + K + K EDK+L + EEL
Sbjct: 1154 QEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEEL 1213
Query: 261 THKLSIITTKMDA-NDKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVEVKH 319
+L I K +A + K L A +++ +T + A V
Sbjct: 1214 AIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSE 1273
Query: 320 LQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKILPFTSMRHQGTQK 379
L+ +L++ E NI + L + E + KS++AD + L T+K
Sbjct: 1274 LEAQLRQLTEEQNTLNISFQQATHQLEEKE-----NQIKSMKADIESLV--------TEK 1320
Query: 380 SDVPPLTTKGKKATGNIDHKEKS-TEINHEIPHCVN--KLPKQEDSKRKYEDLSGEEKHL 436
L +G KE T++ E+ +N L K+E ++K E S ++
Sbjct: 1321 E---ALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLT 1377
Query: 437 EVQILLENTGRQKDK--------KEDQEKKNIFVKEEQELPPKIIEVIHPERESNQEDV 487
++ + L+N+ +K K+ E+K + + Q+L K ++ + E+ S E V
Sbjct: 1378 DLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFK-VDTLSKEKISALEQV 1435
Score = 43.9 bits (102), Expect = 5e-04
Identities = 41/173 (23%), Positives = 78/173 (45%), Gaps = 17/173 (9%)
Query: 176 KQLQLRHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQL 235
+ L+L+H + + N Q+ K Q +++ + K+QE E L +E +QL
Sbjct: 1984 EDLELKHNSTLKQLMREFNT--QLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQL 2041
Query: 236 LK----TKDILQALQKLSEDKNLAEREELTHKLSIITTKMDANDKKIQSLEKQL------ 285
LK D L+ K E+ A EE+T K+ + T+++ KK Q +Q
Sbjct: 2042 LKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGND 2101
Query: 286 RLNCRAFSRQLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKDRELEIKNIYS 338
+ QLA +T ++ + + ++ +L+ +LK+ + KN+Y+
Sbjct: 2102 NVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYE-----KNVYA 2149
Score = 42.7 bits (99), Expect = 0.001
Identities = 74/342 (21%), Positives = 146/342 (42%), Gaps = 52/342 (15%)
Query: 144 LSARLHKIKGLKNELADM---HHKLEAILT--ENQFLKQLQLRHLKAIGKYENSQNNLPQ 198
L + +++ L +EL+++ HKLE L+ ++Q K Q K + + Q +
Sbjct: 679 LDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDS 738
Query: 199 IMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAERE 258
I+ +H+ ++ + L+ ++ L L+E D L K+ ++ L D +E E
Sbjct: 739 IIKEHEVSIQRTEKALK---DQINQLELLLKERDKHL---KEHQAHVENLEADIKRSEGE 792
Query: 259 ELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVEVK 318
L + K+D QS + +A+ QLA +K L +T L +V
Sbjct: 793 -----LQQASAKLDV----FQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVA 843
Query: 319 HLQQKLKEKDRELEIKNIYSHRILKNL--HDTEDYPKVSS------------TKSVQADR 364
++ + K+ EL+ I +++ L ++E KV S K + +
Sbjct: 844 EVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTK 903
Query: 365 KILPFTS---MRHQGTQKSDVPPLTTK--GKKATGNIDHKEKSTEINHEIPHCVNKLPKQ 419
+IL ++ + QK ++ LT K K+ + +I ++E T+ N+ K
Sbjct: 904 QILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFK-------NQEKKM 956
Query: 420 EDSKRKYEDLSGE------EKHLEVQILLENTGRQKDKKEDQ 455
E K+K +++ ++ +++ LENT + +KE Q
Sbjct: 957 EKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQ 998
Score = 42.7 bits (99), Expect = 0.001
Identities = 65/292 (22%), Positives = 133/292 (45%), Gaps = 50/292 (17%)
Query: 77 EKAINRNYLKQPVVKEKEKKKYNVSKISQSKGQKEISVEKKHTWNASLFNSQIHMIAQRR 136
EK N LK+ + +++ K+++ K + ++ EKK + + SQ I +
Sbjct: 1476 EKDEQINLLKEEL--DQQNKRFDCLKGEMEDDKSKM--EKKESNLETELKSQTARIMELE 1531
Query: 137 DAMAHRILSAR-LHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKY-ENSQN 194
D + + + L+++ N+ D+ HK + +++LQ H + +G+ +N
Sbjct: 1532 DHITQKTIEIESLNEVLKNYNQQKDIEHK--------ELVQKLQ--HFQELGEEKDNRVK 1581
Query: 195 NLPQIMAKHQNEVKNLR-QLLRKSQEKERT-LSRKLRETDSQLLKTKDILQALQKLSEDK 252
+ + +N+V +++ +L K +E E LS K +E + + L+ + ++ KL+E K
Sbjct: 1582 EAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELK 1641
Query: 253 NLAE----------------REELTHK-----LSIITTKMDANDKKIQSLEKQLRLNCRA 291
AE +EE K LS + TK+ ++++ LE++L+ +
Sbjct: 1642 RKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESS 1701
Query: 292 FSRQLAI-ETRKTLAAQT----------ATKTLQVEVKHLQQKLKEKDRELE 332
S L + + K +AA T KT + ++ LQ+ L EK++ L+
Sbjct: 1702 QSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQ 1753
Score = 41.6 bits (96), Expect = 0.002
Identities = 80/394 (20%), Positives = 167/394 (42%), Gaps = 49/394 (12%)
Query: 131 MIAQRRDAMAHRILSARLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHL-KAIGKY 189
+IA+ + M H L + +I L++ + M + E + + + ++ L KA+
Sbjct: 365 VIAETKRQM-HETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTA 423
Query: 190 ENSQNNLPQIMAKHQNEVKNLRQLLRKSQEKERT-----LSRKLRETDSQLLKT-KDILQ 243
+ ++ ++ A+ ++K + K+ E+ER LSR +E + K+ ++ +
Sbjct: 424 QKTEEARRKLKAEMDEQIKTIE----KTSEEERISLQQELSRVKQEVVDVMKKSSEEQIA 479
Query: 244 ALQKLSEDKNLAEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKT 303
LQKL E + + +ELT KL T + + ++ +LEK + S L I K
Sbjct: 480 KLQKLHEKELARKEQELTKKLQ--TREREFQEQMKVALEK-------SQSEYLKISQEKE 530
Query: 304 LAAQTATKTLQVEVKHL----QQKLKEKDRE--------LEIKNIYSHRILKNLHDTEDY 351
A + L+++ K + + KL++ +E LE+++ + +N + ++D
Sbjct: 531 QQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDL 590
Query: 352 P--------KVSSTKSVQADRKILPFTSMRHQ----GTQKSDV--PPLTTKGKKATGNID 397
K + +V ++ S++HQ T+K V T+ +K +
Sbjct: 591 AVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCE 650
Query: 398 HKEKSTEINHEIPHCVNKLPKQEDSKRKYEDLSGEEKHLEVQILLENTGRQKDKKEDQEK 457
++++ + EI + E + K + E + L ++ R K ++E
Sbjct: 651 QEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVL 710
Query: 458 KNIFVKEEQELPPKIIEVIHPERESNQEDVLVRE 491
K+ K +QEL K+ E Q D +++E
Sbjct: 711 KDQTDKMKQELEAKMDE--QKNHHQQQVDSIIKE 742
Score = 41.2 bits (95), Expect = 0.003
Identities = 85/434 (19%), Positives = 175/434 (40%), Gaps = 70/434 (16%)
Query: 159 ADMHHKLEAILTENQFLKQLQL-----RHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQL 213
+DM + E ++ + L + QL R +++ Y + L Q E K L+ +
Sbjct: 118 SDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGI 177
Query: 214 LRKSQEKERTLSRKLRE-------------------------------TDSQLLKTK--- 239
L +SQ+K +LRE T LLK +
Sbjct: 178 LSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRN 237
Query: 240 -----DILQALQKLSEDKNLAEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSR 294
D+L+ L +L + +EE + + K +++L+++++
Sbjct: 238 GPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKR-----QE 292
Query: 295 QLAIETRKTLAAQTATKTLQVEVKH-LQQKLKEKDRELE-IKNIY---SHRILKNLHDT- 348
L ++T+ + TL K LQ++L E+ +ELE IK+++ +++ L D
Sbjct: 293 NLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAK 352
Query: 349 ---EDYPKVSSTKSVQADRKILPFTSMRHQ--GTQKSDVPPLTTKGKKATGNIDHKEKST 403
E + + R++ M+ + +S + +TT+G++ + KEKS
Sbjct: 353 NLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELR---EQKEKSE 409
Query: 404 EIN-HEIPHCVNKLPKQEDSKRKYE-DLSGEEKHLEVQILLENTGRQKD-KKEDQEKKNI 460
E+ ++ K E+++RK + ++ + K +E E Q++ + QE ++
Sbjct: 410 RAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDV 469
Query: 461 FVKEEQELPPKIIEVIHPERESNQEDVLVREKFKRSMQ-RNGVDDTLGKGTAPYTKGPLR 519
K +E K ++ +H + + +E L ++ R + + + L K + Y K +
Sbjct: 470 MKKSSEEQIAK-LQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLK--IS 526
Query: 520 QRRHYSFTEATENL 533
Q + + A E L
Sbjct: 527 QEKEQQESLALEEL 540
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 55.8 bits (133), Expect = 1e-07
Identities = 88/400 (22%), Positives = 169/400 (42%), Gaps = 59/400 (14%)
Query: 100 VSKISQSKGQKEISVEKKHTWNASLFNSQIHMIAQRRDAMAHRILSARLHKIKGLKNELA 159
+ ++S KG+ + + ++ T Q+ +I Q + L L ++ K EL
Sbjct: 1649 LEELSFQKGELNVQISERKT--------QLTLIKQEIEKEEEN-LQVVLRQMSKHKTELK 1699
Query: 160 DMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQ----------NNLPQIMAKHQNEVKN 209
++ L+ + EN L+ L+L+H + + + E +Q NL QI + + E++
Sbjct: 1700 NI---LDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEW 1756
Query: 210 LRQLLRKSQ---EKERTLSRKLRETDSQLLKTKDILQAL-----QKLSEDKN-LAEREEL 260
+QLL + + E+ SR L+ L K K+ LQ +KL++ K LA EE
Sbjct: 1757 QKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEEN 1816
Query: 261 THKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVEVKHL 320
+ K++ N +K+Q QL + + ++ ++ + A +LQ E+ ++
Sbjct: 1817 SKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANV 1876
Query: 321 QQKLKEKDREL-------EIKNIYSHRILKNLHD----TEDYPKVSSTK---------SV 360
Q L ++L ++ R+ K++ + ED K TK +
Sbjct: 1877 QDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEI 1936
Query: 361 QADRKILPFTSMRHQGTQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVNK----L 416
+ ++ L M Q QK + + K T + KE+ ++ E+ +K L
Sbjct: 1937 EENKLKLVQQEMMFQRLQKERE---SEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVL 1993
Query: 417 PKQEDSKRKYEDLSGEEKHLE-VQILLENTGRQKDKKEDQ 455
K ++ + L EE+ E ++ L T RQ ++E Q
Sbjct: 1994 SKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQ 2033
Score = 41.2 bits (95), Expect = 0.003
Identities = 80/394 (20%), Positives = 159/394 (40%), Gaps = 64/394 (16%)
Query: 77 EKAINRNYLKQPVVKEKEKKKYNVSKISQSKGQKEISVEKKHTWNASLFNSQIHMIAQRR 136
E +N + +KE+ +K ++++ QS Q E+ E R
Sbjct: 709 EARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKE--------------------R 748
Query: 137 DAMAHRILSARLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNL 196
A+ + + A+ + K +N +++H KL+ + +N LKQ QL+ ++N N++
Sbjct: 749 QALKNALGKAQFSEEKEQEN--SELHAKLKHLQDDNNLLKQ-QLK------DFQNHLNHV 799
Query: 197 PQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAE 256
+ + + + +L RK K T + L K+ LQ ++ E
Sbjct: 800 VDGLVRPEEVAARVDELRRKL--KLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWE 857
Query: 257 REELTHKLSIITTKMDANDKKIQSLEKQLRLNC-RAFSRQLAIETRKTLAAQTATKTLQV 315
R+E + + +M +K+ + +++ R C RA ++ + R+ + + ++
Sbjct: 858 RDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQ---HEARIQQMEN 914
Query: 316 EVKHLQQKLKE-------KDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQ----ADR 364
E+ +LQ+ LK D +L+ + RIL L + E K+ KS + D+
Sbjct: 915 EIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDK 974
Query: 365 KILPFTSMRHQGTQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVN-----KLPKQ 419
++ K + T K AT + + + H +N +L +
Sbjct: 975 EL------------KKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEA 1022
Query: 420 EDSKRKYEDLSGEEKHLEVQI-LLENTGRQKDKK 452
E RK + + E +I LL+N RQK ++
Sbjct: 1023 ERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQ 1056
Score = 40.4 bits (93), Expect = 0.005
Identities = 83/382 (21%), Positives = 161/382 (42%), Gaps = 40/382 (10%)
Query: 133 AQRRDAMAHRILSARLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENS 192
A R A A LS K K + D L + TE+ ++L+ R + +
Sbjct: 1438 ADRLLAEAESELSCTKEKTKNAVEKFTDAKRSL--LQTESD-AEELERRAQETAVNLVKA 1494
Query: 193 QNNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKL--RETDSQLL--KTKDILQALQKL 248
L + A + K+L Q K +E + +++ + +++D Q L K + + + LQKL
Sbjct: 1495 DQQLRSLQA----DAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKL 1550
Query: 249 SEDKNLAEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQT 308
+D +AER E H L ++ K LEK L+ + +++A+ R+ +
Sbjct: 1551 QKDIEMAERNE-DHHLQVLKESEVLLQAKRAELEK-LKSQVTSQQQEMAVLDRQLGHKKE 1608
Query: 309 ATKTLQVEVKHLQQKLKEKDR--ELEIKNIYSH-RILKNLHDTEDYPKVSSTKSVQADRK 365
LQ + + L+E R E E+ +H R +K+L + + K +VQ +
Sbjct: 1609 ELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQK--GELNVQISER 1666
Query: 366 ILPFTSMRHQGTQKSD----VPPLTTKGKKATGNI-------DHKEKSTEINHEIPHCVN 414
T ++ + ++ + V +K K NI +H+ + ++ H+ V+
Sbjct: 1667 KTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHD--QRVS 1724
Query: 415 KLPKQE----DSKRKYEDLSGEEKHLEVQILLENTGRQKDKKEDQEKKNIFVKEEQELPP 470
+L K + + K + E+L + + +I + ++DK+E + + E
Sbjct: 1725 ELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIER-----MTAESRALQ 1779
Query: 471 KIIEVIHPERESNQEDVLVREK 492
+E + E+E QE + EK
Sbjct: 1780 SCVECLSKEKEDLQEKCDIWEK 1801
Score = 33.1 bits (74), Expect = 0.85
Identities = 68/325 (20%), Positives = 130/325 (40%), Gaps = 39/325 (12%)
Query: 234 QLLKTKDILQALQKLSEDKNLAEREELTHKLSIITTKMDANDKKIQSLEKQLR------- 286
Q LK+K + + S+ ++ E EEL H + + + + + +++ L + ++
Sbjct: 1333 QHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKD 1392
Query: 287 -LNCRAFSRQLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNL 345
++ S +E K+L + + E++ +++ L ++ EL + L
Sbjct: 1393 FIDGNVESLMTELEIEKSLKHH---EDIVDEIECIEKTLLKRRSELREADRLLAEAESEL 1449
Query: 346 HDTEDYPKVSSTKSVQADRKILPFTS------MRHQGTQ----KSDVPPLTTKGKKATGN 395
T++ K + K A R +L S R Q T K+D L + A
Sbjct: 1450 SCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKAD-QQLRSLQADAKDL 1508
Query: 396 IDHKEKSTEINHEIPHCVNKLPKQEDS-----KRKYEDLSGEEKHLEVQILLENTGRQKD 450
HK K EI EI NK+ +DS +K E L+ E + L+ I +
Sbjct: 1509 EQHKIKQEEILKEI----NKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHH 1564
Query: 451 KKEDQEKKNIFVKEEQELPPKIIEVIHPERESNQEDVLVREKFKRSMQRNGVDDTLGKGT 510
+ +E + + + EL E + + S Q+++ V + R + + L +G+
Sbjct: 1565 LQVLKESEVLLQAKRAEL-----EKLKSQVTSQQQEMAVLD---RQLGHKKEELHLLQGS 1616
Query: 511 APYTKGPLRQRRHYSFTEATENLHH 535
K L++ TE TE +H
Sbjct: 1617 MVQAKADLQEALRLGETEVTEKCNH 1641
Score = 29.6 bits (65), Expect = 9.4
Identities = 47/224 (20%), Positives = 98/224 (43%), Gaps = 32/224 (14%)
Query: 277 KIQSLEKQLRLN--CRAFSRQLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKDRELEIK 334
KI+ L+K L+L ++++ IE + + E++H+ L +K + L +
Sbjct: 139 KIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVL 198
Query: 335 NIYSHRI--LKNLHDTEDYPKVSSTKSVQADRKILP----FTSMRHQGTQKSDVPPLTTK 388
N+ ++I L+++ + + S V+ LP FT + + + P+TT+
Sbjct: 199 NLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQ 258
Query: 389 GKKATGNIDHKEKSTEINHEIPHCVNKLPKQEDSKRKYEDLSGEEKHLEVQILLENTGRQ 448
D +E + E+ +R DL E+K +E + L R
Sbjct: 259 --------DRQEAFERFS------------LEEVERLERDL--EKKMIETEELKSKQTRF 296
Query: 449 KDKKEDQEKKNIFVKEEQELPPKIIEVIHPERESNQEDVLVREK 492
++ ++Q+K N +KEE L + E + + + N ++ L+++K
Sbjct: 297 LEEIKNQDKLNKSLKEEAMLQKQSCEEL--KSDLNTKNELLKQK 338
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 55.1 bits (131), Expect = 2e-07
Identities = 91/442 (20%), Positives = 192/442 (43%), Gaps = 43/442 (9%)
Query: 86 KQPVVKEKEKKKYNVSKISQSKGQKEISVEKKHTWNASLFNSQIHMIAQRRDAMAHRILS 145
KQ + ++ +KK++ +S++ Q +I E+ H+ F +I + R + + I +
Sbjct: 1077 KQQIEEKLKKKEFELSQL-----QAKIDDEQVHSLQ---FQKKIKELQARIEELEEEIEA 1128
Query: 146 ARLHKIKGLKNELADMHHKLEAI---LTENQFLKQLQLR-HLKAIGKYENSQNNLPQIMA 201
+ K ++ + +D+ +LE I L E Q+ + K +++ + +L +
Sbjct: 1129 EHTLRAK-IEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATL 1187
Query: 202 KHQNEVKNLRQL-------LRKSQEKERTLSRKLRETDSQL-LKTKDILQALQKLSEDKN 253
+H+ LR+ L + + + + +KL + S+L ++ D+ ++ LS+ K+
Sbjct: 1188 QHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKS 1247
Query: 254 LAER--EELTHKLSIITTKMDANDKKIQSLEKQ-LRLNCRAFSRQLAIETRKTLAAQTAT 310
ER + + S I K + + I L Q RL + +E +++L +Q T
Sbjct: 1248 NIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQL-T 1306
Query: 311 KTLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHD----TEDYPKVSSTKSVQADRKI 366
K+ Q + L++ ++ + E + KN +H + + HD E Y + K+ + R +
Sbjct: 1307 KSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKA-ELQRAL 1365
Query: 367 LPFTSMRHQGTQK--SDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVNKLPKQEDSKR 424
S Q K +D T + ++A + + + E N E + +K E +K+
Sbjct: 1366 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETAN--SKCASLEKTKQ 1423
Query: 425 KYEDLSGEEKHLEVQILLENTGRQKDKKEDQEKKNIFVKEEQELPPKIIEVIHPERESNQ 484
+ L GE + L + +T K+ + + + +Q+L E+ ++ES
Sbjct: 1424 R---LQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRS 1480
Query: 485 EDVLVREKFKRSMQRNGVDDTL 506
L E FK RN ++ +
Sbjct: 1481 ---LSTELFK---MRNAYEEVV 1496
Score = 53.9 bits (128), Expect = 5e-07
Identities = 87/438 (19%), Positives = 180/438 (41%), Gaps = 29/438 (6%)
Query: 70 DFLCDCSEKAINRNYLKQPVVKEKEKKKYNVSKIS---QSKGQKEISVEKKHTWNASLFN 126
D + + E+ N +KQ + KEK + K + ++ ++ + + ++E+ F
Sbjct: 1202 DSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQF- 1260
Query: 127 SQIHMIAQRRDAMAH--RILSARLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLK 184
S+I +++ + H + ARL G + + L + LT+++ QL LK
Sbjct: 1261 SEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELK 1320
Query: 185 AIGKYE-NSQNNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLL--KTKDI 241
+ E ++N + + +++ LR+ + QE + L R L + +S++ +TK
Sbjct: 1321 RQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYE 1380
Query: 242 LQALQKLSEDKNLAEREELTHKLSIITTKMDANDKKIQSLEK-QLRLNCRAFSRQLAIET 300
A+Q+ E + +++L +L + + K SLEK + RL +E
Sbjct: 1381 TDAIQRTEELEE--AKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLER 1438
Query: 301 RKTLAAQTATKTLQVE--VKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTK 358
T A K + + +QKL E ELE S + TE + ++ +
Sbjct: 1439 SHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSL-----STELFKMRNAYE 1493
Query: 359 SVQADRKILPFTSMRHQGTQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVNKLPK 418
V + T R + ++ LT + + N+ EK+ ++ + + +
Sbjct: 1494 EVVDQLE----TLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALE 1549
Query: 419 QEDSKRKYEDLSGEEKHLEVQILLENTGRQKDKK--EDQEKKNIFVKEEQELPPKIIEVI 476
+ + ++E E K L VQ+ L + D+K E E+ + Q + V+
Sbjct: 1550 EVEGSLEHE----ESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVL 1605
Query: 477 HPERESNQEDVLVREKFK 494
E S + + +++K +
Sbjct: 1606 DAEIRSRNDALRLKKKME 1623
Score = 38.9 bits (89), Expect = 0.016
Identities = 40/216 (18%), Positives = 93/216 (43%), Gaps = 26/216 (12%)
Query: 68 SEDFLCDCSEKAINRNYLKQPVVKEKEKKKYNV-------------SKISQSKGQKEIS- 113
SE L D S++ + ++ K+K + ++ S+ ++ K +K I+
Sbjct: 1706 SEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITD 1765
Query: 114 -------VEKKHTWNASLFNSQIHMIAQRRDAMAHRILSARLHKIKGLKNELADMHHKLE 166
++K+ +A L + ++ +D + HR+ A +KG K ++ + +++
Sbjct: 1766 AAMMAEELKKEQDTSAHLERMKKNLEQTVKD-LQHRLDEAEQLALKGGKKQIQKLENRVR 1824
Query: 167 AILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSR 226
+ E ++ LK KYE + + + L+ L+ K Q K ++ R
Sbjct: 1825 ELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKR 1884
Query: 227 KLRETD----SQLLKTKDILQALQKLSEDKNLAERE 258
+ E + +QL + + + L++ +E ++AE +
Sbjct: 1885 QAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQ 1920
Score = 33.1 bits (74), Expect = 0.85
Identities = 33/131 (25%), Positives = 62/131 (47%), Gaps = 18/131 (13%)
Query: 204 QNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAEREELTHK 263
+N+VKNL + + L E S+L K K LQ + + D +L E+ +
Sbjct: 976 ENKVKNLSEEM-----------TALEENISKLTKEKKSLQEAHQQTLD-DLQVEEDKVNG 1023
Query: 264 LSIITTKMDANDKKIQ---SLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVEVKHL 320
L I K++ ++ EK+LR + R+L + + +Q + L+ + + +
Sbjct: 1024 LIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLK---MSQESIMDLENDKQQI 1080
Query: 321 QQKLKEKDREL 331
++KLK+K+ EL
Sbjct: 1081 EEKLKKKEFEL 1091
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 54.7 bits (130), Expect = 3e-07
Identities = 67/339 (19%), Positives = 148/339 (43%), Gaps = 55/339 (16%)
Query: 61 LSSQYDYSEDFLCDCSEKAINRNYLKQPVVKEKEKKKYNVSKISQSKGQ----------- 109
LSS + + L D K ++ ++ ++K KEK + ++++I + G
Sbjct: 845 LSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDE 904
Query: 110 ---KEISVEK------KHTWNASLFNSQIHMIAQRRDAMAHRILSARLHKIKGLKNELAD 160
KE VE+ K NAS I + + + + K L+ +L+D
Sbjct: 905 LRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSD 964
Query: 161 MHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQEK 220
+ K+E T + ++L+ R+ +A + + +I+ Q + + L+ ++E+
Sbjct: 965 LEKKME---TSHNQCQELKARYERATSETKTKHE---EILQNLQKTLLDTEDKLKGAREE 1018
Query: 221 ERTLSRKLRETDSQLLKTK------DILQALQKLSEDK-----NLAEREELTHKL-SIIT 268
L ++L E Q K K D +Q +++++++K +L + ++ KL + +
Sbjct: 1019 NSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELD 1078
Query: 269 TKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKD 328
T + N K ++ L K L L +E +K + + E++ L+Q +K
Sbjct: 1079 TLKENNLKNVEELNKSKEL--------LTVENQK-------MEEFRKEIETLKQAAAQKS 1123
Query: 329 RELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKIL 367
++L + ++ + L + D +V+S + ++ +R +L
Sbjct: 1124 QQLSALQEENVKLAEELGRSRD--EVTSHQKLEEERSVL 1160
Score = 43.9 bits (102), Expect = 5e-04
Identities = 67/364 (18%), Positives = 146/364 (40%), Gaps = 65/364 (17%)
Query: 6 LTKTNIDEHFFGVALEN-------NRRSAACKRSPGTGDFSRNSNASNKSVDYSRSQCSC 58
LTK N + F ++E+ +++ AA K + R + K ++ S +QC
Sbjct: 919 LTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQ- 977
Query: 59 GSLSSQYDYSEDFLCDCSEKAINRNYLKQPVVKEKEKKKYNVSKISQSKGQKEISVEKKH 118
L ++Y E+A + K + + +K + + KG +E
Sbjct: 978 -ELKARY-----------ERATSETKTKHEEILQNLQKTL-LDTEDKLKGAREE------ 1018
Query: 119 TWNASLFNSQIHMIAQRRDAMAHRILSARLHKIKGLKNELADMHHKLE-------AILTE 171
N+ L + Q A A + + ++ + E + LE + E
Sbjct: 1019 --NSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNE 1076
Query: 172 NQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRET 231
LK+ L++++ + K + Q M + + E++ L+Q + ++ L + +
Sbjct: 1077 LDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKL 1136
Query: 232 DSQLLKTKDILQALQKLSEDKNL--------------------AEREELTHKLSIITTKM 271
+L +++D + + QKL E++++ E+ L +SI + +
Sbjct: 1137 AEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALL 1196
Query: 272 DANDKKIQSLEKQLRL----NCRAFSRQLAIETRKTLAAQTATKTLQVEVKHLQQKLKEK 327
D +++ L ++ + N A S ++T ++ L+++VK+L+ +LKE
Sbjct: 1197 TEKDAELEKLRNEVTVLRGENASAKSLHSVVQT-----LESDKVKLELKVKNLELQLKEN 1251
Query: 328 DREL 331
R+L
Sbjct: 1252 KRQL 1255
Score = 42.4 bits (98), Expect = 0.001
Identities = 74/418 (17%), Positives = 174/418 (41%), Gaps = 41/418 (9%)
Query: 92 EKEKKK-----YNVSKISQSKGQKEISVEKKHTWNASLFNS---QIHMIAQRRDAMAHRI 143
E+EK+K + V + S +KG E++ + + L ++ +A+ R +
Sbjct: 432 EEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNK 491
Query: 144 LSARLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMAKH 203
+ + L E++ + KLE T++Q R + ++ ++ ++ H
Sbjct: 492 PAGDVDMSLSLLQEISSLQEKLEVTRTDHQ-------REITSLKEHFGAREET------H 538
Query: 204 QNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAEREELTHK 263
Q E+K L K ++ +L KL + + D++ AL K + +A ++ +
Sbjct: 539 QKEIKALYTATEKLSKENESLKSKLEHANKE---NSDVI-ALWKSKLETAIASHQQAMEE 594
Query: 264 LSIITTK-MDANDKKIQSLEKQLRLNCRAFSRQLA-IETRKTLAAQTATKTLQVEVKHLQ 321
L + +K + + L+ Q+ + ++ ++ ++ K ++ L
Sbjct: 595 LKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLM 654
Query: 322 QKLKEKDRELE-IKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKILPFTSMRHQGTQKS 380
+ +KEK+ LE I++ ++L + ED + K +A+ K+ ++ + +++
Sbjct: 655 KVIKEKENSLEAIRSKLDKAEDQHLVEMED----TLNKLQEAEIKVKELEVLQAKCNEQT 710
Query: 381 DVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVNKLPKQEDSKRKYEDLSGEEKHLEVQI 440
V T KAT +EK +++ + + +++ E + KHLE++
Sbjct: 711 KVIDNFTSQLKAT-----EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEK 765
Query: 441 LLENTGRQKDKKEDQEKKNIFVKEEQELPPKIIEVIHPERESNQEDVLVREKFKRSMQ 498
E++ +E Q ++ ++ L EV + +E +++EKF + +
Sbjct: 766 NAESSKASSITRELQGRELKLTNLQENLS----EVSQVKETLEKELQILKEKFAEASE 819
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 54.7 bits (130), Expect = 3e-07
Identities = 67/339 (19%), Positives = 148/339 (43%), Gaps = 55/339 (16%)
Query: 61 LSSQYDYSEDFLCDCSEKAINRNYLKQPVVKEKEKKKYNVSKISQSKGQ----------- 109
LSS + + L D K ++ ++ ++K KEK + ++++I + G
Sbjct: 880 LSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDE 939
Query: 110 ---KEISVEK------KHTWNASLFNSQIHMIAQRRDAMAHRILSARLHKIKGLKNELAD 160
KE VE+ K NAS I + + + + K L+ +L+D
Sbjct: 940 LRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSD 999
Query: 161 MHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQEK 220
+ K+E T + ++L+ R+ +A + + +I+ Q + + L+ ++E+
Sbjct: 1000 LEKKME---TSHNQCQELKARYERATSETKTKHE---EILQNLQKTLLDTEDKLKGAREE 1053
Query: 221 ERTLSRKLRETDSQLLKTK------DILQALQKLSEDK-----NLAEREELTHKL-SIIT 268
L ++L E Q K K D +Q +++++++K +L + ++ KL + +
Sbjct: 1054 NSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELD 1113
Query: 269 TKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKD 328
T + N K ++ L K L L +E +K + + E++ L+Q +K
Sbjct: 1114 TLKENNLKNVEELNKSKEL--------LTVENQK-------MEEFRKEIETLKQAAAQKS 1158
Query: 329 RELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKIL 367
++L + ++ + L + D +V+S + ++ +R +L
Sbjct: 1159 QQLSALQEENVKLAEELGRSRD--EVTSHQKLEEERSVL 1195
Score = 43.9 bits (102), Expect = 5e-04
Identities = 67/364 (18%), Positives = 146/364 (40%), Gaps = 65/364 (17%)
Query: 6 LTKTNIDEHFFGVALEN-------NRRSAACKRSPGTGDFSRNSNASNKSVDYSRSQCSC 58
LTK N + F ++E+ +++ AA K + R + K ++ S +QC
Sbjct: 954 LTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQ- 1012
Query: 59 GSLSSQYDYSEDFLCDCSEKAINRNYLKQPVVKEKEKKKYNVSKISQSKGQKEISVEKKH 118
L ++Y E+A + K + + +K + + KG +E
Sbjct: 1013 -ELKARY-----------ERATSETKTKHEEILQNLQKTL-LDTEDKLKGAREE------ 1053
Query: 119 TWNASLFNSQIHMIAQRRDAMAHRILSARLHKIKGLKNELADMHHKLE-------AILTE 171
N+ L + Q A A + + ++ + E + LE + E
Sbjct: 1054 --NSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNE 1111
Query: 172 NQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRET 231
LK+ L++++ + K + Q M + + E++ L+Q + ++ L + +
Sbjct: 1112 LDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKL 1171
Query: 232 DSQLLKTKDILQALQKLSEDKNL--------------------AEREELTHKLSIITTKM 271
+L +++D + + QKL E++++ E+ L +SI + +
Sbjct: 1172 AEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALL 1231
Query: 272 DANDKKIQSLEKQLRL----NCRAFSRQLAIETRKTLAAQTATKTLQVEVKHLQQKLKEK 327
D +++ L ++ + N A S ++T ++ L+++VK+L+ +LKE
Sbjct: 1232 TEKDAELEKLRNEVTVLRGENASAKSLHSVVQT-----LESDKVKLELKVKNLELQLKEN 1286
Query: 328 DREL 331
R+L
Sbjct: 1287 KRQL 1290
Score = 38.5 bits (88), Expect = 0.020
Identities = 62/348 (17%), Positives = 146/348 (41%), Gaps = 33/348 (9%)
Query: 154 LKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQL 213
L E++ + KLE T++Q R + ++ ++ ++ HQ E+K L
Sbjct: 537 LLQEISSLQEKLEVTRTDHQ-------REITSLKEHFGAREET------HQKEIKALYTA 583
Query: 214 LRKSQEKERTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAEREELTHKLSIITTK-MD 272
K ++ +L KL + + D++ AL K + +A ++ +L + +K +
Sbjct: 584 TEKLSKENESLKSKLEHANKE---NSDVI-ALWKSKLETAIASHQQAMEELKVSFSKGLG 639
Query: 273 ANDKKIQSLEKQLRLNCRAFSRQLA-IETRKTLAAQTATKTLQVEVKHLQQKLKEKDREL 331
+ L+ Q+ + ++ ++ ++ K ++ L + +KEK+ L
Sbjct: 640 TETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSL 699
Query: 332 E-IKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKILPFTSMRHQGTQKSDVPPLTTKGK 390
E I++ ++L + ED + K +A+ K+ ++ + +++ V T
Sbjct: 700 EAIRSKLDKAEDQHLVEMED----TLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQL 755
Query: 391 KATGNIDHKEKSTEINHEIPHCVNKLPKQEDSKRKYEDLSGEEKHLEVQILLENTGRQKD 450
KAT +EK +++ + + +++ E + KHLE++ E++
Sbjct: 756 KAT-----EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSI 810
Query: 451 KKEDQEKKNIFVKEEQELPPKIIEVIHPERESNQEDVLVREKFKRSMQ 498
+E Q ++ ++ L EV + +E +++EKF + +
Sbjct: 811 TRELQGRELKLTNLQENLS----EVSQVKETLEKELQILKEKFAEASE 854
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 54.7 bits (130), Expect = 3e-07
Identities = 84/408 (20%), Positives = 169/408 (41%), Gaps = 43/408 (10%)
Query: 92 EKEKKKYNVSKISQSKGQKEISVE--KKHTWNASLF---NSQIHMIAQRRDAMAHRILSA 146
E +KK + ++++ KE+ +E KK N Q IA+ ++
Sbjct: 411 ELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGL 470
Query: 147 RLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNN-LPQIMAKHQN 205
++ + E+ D+ +L AI T Q+ + +++ LK + E +N L K
Sbjct: 471 ----LQAREKEVHDLEIQLTAITTSEQYYSK-EVKDLKTELENEKLKNTELTSHCNKLSL 525
Query: 206 EVKNLRQ------LLRKSQEKERTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAEREE 259
E K L Q L K+Q+++ ++K E ++LK + LQ + ++ REE
Sbjct: 526 ENKELTQETSDMTLELKNQQEDINNNKKQEE---RMLKQIENLQETETQLRNELEYVREE 582
Query: 260 LTHKLSIITTKMDANDKKIQSLEKQ----------LRLNCRAFSRQLAIETRKTLAAQTA 309
L K + K+D +++ +L KQ L+ +A ++ E+++ +
Sbjct: 583 LKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIK 642
Query: 310 TKTLQVEVKHLQQKLKE----KDRELEIKNIYSHRILKNLHD----TEDYPKVSSTKSVQ 361
L++E++ +QK E +E+E K I +L+ + ++ K+ +
Sbjct: 643 VNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKR 702
Query: 362 ADRKILPFTSMRHQGTQKSDVPPLTTKGKKATGNIDHKE-KSTEINHEIPHCVNKLPKQE 420
KI ++ + K + + G KE + + + + ++ L +
Sbjct: 703 CQHKIAEMVALMEK--HKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAEL 760
Query: 421 DSKRKYEDLSGEEKHLEVQILLENTGRQKDKKEDQEKKNIFVKEEQEL 468
S +K ++ EEK + ENT K+KK+ +K F+ E E+
Sbjct: 761 LSVKKQLEIEREEKEKLKREAKENTATLKEKKD--KKTQTFLLETPEI 806
Score = 48.1 bits (113), Expect = 3e-05
Identities = 73/365 (20%), Positives = 157/365 (43%), Gaps = 36/365 (9%)
Query: 155 KNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQLL 214
+N +MH KL+ + Q L+Q + K I E + L + + +N++K+L LL
Sbjct: 233 ENSRLEMHFKLKEDYEKIQHLEQ---EYKKEINDKEKQVSLLLIQITEKENKMKDLTFLL 289
Query: 215 RKSQEKERTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAEREELTHKLSIITTKMDAN 274
+S++K L K + L+++++ Q+++K E +++ + S+ T K
Sbjct: 290 EESRDKVNQLEEKTK------LQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEE 343
Query: 275 D-----KKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKDR 329
D K I L ++ ++ A + +T +L+ ++ QQ+L++ +
Sbjct: 344 DLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNED 403
Query: 330 ELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQAD--RKIL-----------PFTSMRHQ- 375
+L+I + + K + E+ K+++ K V+ + +K+L F + +
Sbjct: 404 QLKILTM---ELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEEL 460
Query: 376 -GTQKSDVPPLTTKGKKATG-NIDHKEKSTEINHEIPHCVNKLPKQEDSKRKYEDLSGEE 433
GT++ + L + K+ I +T + + + E+ K K +L+
Sbjct: 461 KGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHC 520
Query: 434 KHLEVQ---ILLENTGRQKDKKEDQEKKNIFVKEEQELPPKIIEVIHPERESNQEDVLVR 490
L ++ + E + + K QE N K+E+ + +I + E + E VR
Sbjct: 521 NKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVR 580
Query: 491 EKFKR 495
E+ K+
Sbjct: 581 EELKQ 585
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 54.3 bits (129), Expect = 4e-07
Identities = 83/366 (22%), Positives = 154/366 (42%), Gaps = 69/366 (18%)
Query: 149 HKIKGLKNELADMHHKLEAILTE-----NQFLKQLQLRHLKAIGKYENSQNNLPQIMAKH 203
+KI +K EL+ +L A+ T+ NQF Q H++ + + ++ I+
Sbjct: 438 NKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQ--HIEVLKESLTAKEQRAAIL--- 492
Query: 204 QNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQKLSEDKNL--AEREELT 261
Q EV LR L +EKE L++K ++ +Q ++E+K E +L
Sbjct: 493 QTEVDALRLRL---EEKETMLNKKTKQ--------------IQDMAEEKGTQAGEIHDLK 535
Query: 262 HKLSIITTKMDANDKKIQSLEKQLRLNCRAFS------RQLAIETRKTLAAQTATKTLQV 315
L + K++ KKI++L++QLR + S + L +T T A T +
Sbjct: 536 DMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALA 595
Query: 316 EVKHLQQKLKE-KDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKILPFTSMRH 374
E + ++LKE +DR+ K K+L D ++ KVS + ++++ H
Sbjct: 596 EKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKE--KVSLLQGDLSEKEASLLDLKEH 653
Query: 375 QGT---------------------QKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCV 413
+ +K + + ++ KKA S E++ I H
Sbjct: 654 ASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLE 713
Query: 414 NKLPKQEDSKRKYEDLSGEEKHLEVQILLENTGRQKDKK--------EDQEKKNIFVKEE 465
++ + +D K + + ++ LE+ +EN KDKK +DQ KK +K +
Sbjct: 714 REITRYKDESSKAQ--AEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHK 771
Query: 466 QELPPK 471
+++ K
Sbjct: 772 EQVEKK 777
Score = 44.7 bits (104), Expect = 3e-04
Identities = 70/354 (19%), Positives = 149/354 (42%), Gaps = 57/354 (16%)
Query: 156 NELADMHHKLEAILTENQFL-KQLQLRHLKAIGKYENSQNNLPQIMAKHQNEVKNLR--- 211
N + D+ +L+ +L EN L K ++++ K +S N++ + + + LR
Sbjct: 149 NTIMDLQTQLKEVLRENDLLRKDVEVKE----SKLSSSMNSIKTFWSPELKKERALRKDE 204
Query: 212 --------QLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQKLSEDKN---------- 253
+ R QE+ + + ++ +L +D+ Q Q+ S +
Sbjct: 205 ASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTE 264
Query: 254 ------LAEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQ 307
AE E +L ++ ++ + +I++ ++ L + + L + K L+A+
Sbjct: 265 ENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAK 324
Query: 308 TA------TKTL---QVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTK 358
T+ L ++ V HL+ L++K++E + HR +N D+ + TK
Sbjct: 325 ATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDS------AKTK 378
Query: 359 SVQA--DRKILPFTSM-RHQGTQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVNK 415
++Q + K +SM R + ++ L + G +T + + K E+ +K
Sbjct: 379 ALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRS----HSK 434
Query: 416 LPKQEDSKRKYEDLSGEEKHLEVQILLEN-TGRQKDKKEDQE--KKNIFVKEEQ 466
K + + K E + + L +Q LE T + D K+ E K+++ KE++
Sbjct: 435 FMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQR 488
Score = 39.7 bits (91), Expect = 0.009
Identities = 67/327 (20%), Positives = 133/327 (40%), Gaps = 54/327 (16%)
Query: 150 KIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNN----LPQIMAKHQN 205
KI L+ ++ D + K+ + + Q K+ + L+ + E++ N+ L + K +
Sbjct: 750 KIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDD 809
Query: 206 EVKNLRQLLRKS----QEKERTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAEREELT 261
++ L + LR+S E+E L+++ + + +++L A++K+ + E E +
Sbjct: 810 RIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQ-----ELESMK 864
Query: 262 HKLSIITTKMDANDKKIQSLEKQLR------LNCRAFSRQLAIETRKT----LAAQTATK 311
KLS + + + +L + R L + + AI + L ++ K
Sbjct: 865 AKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKK 924
Query: 312 TLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKILPFTS 371
Q EV L+ +EKDR ++ + +K + D + S+ S Q + K P
Sbjct: 925 KTQEEVAALK---REKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQI 981
Query: 372 MR-----------------HQGTQKSDVPPLTTKG--KKATGNIDHKEKSTEINHEIPHC 412
++ H T D PL +G A+ N+D + + E
Sbjct: 982 IQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWE-------- 1033
Query: 413 VNKLPKQEDSKRKYEDLSGEEKHLEVQ 439
N+L K + + E GE + E+Q
Sbjct: 1034 -NELQKMTRGQLQDELEKGERDNAELQ 1059
Score = 37.0 bits (84), Expect = 0.059
Identities = 66/345 (19%), Positives = 139/345 (40%), Gaps = 41/345 (11%)
Query: 181 RHLKAIGKYENSQNNLPQIMAKHQNEVKN----LRQLLRKSQEKERTLSRKLRETDSQLL 236
R L+ + + EN +N+ + +A+ + +VK+ + L K Q +++ ++ L E +
Sbjct: 732 RLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRRED 791
Query: 237 KTKDILQALQK--LSEDKNLAEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSR 294
D Q LQ +D + E EE + + ++ A + + + E+ R N
Sbjct: 792 NLNDSSQQLQDSLRKKDDRIEELEEALRE----SVQITAEREMVLAQEESARTNAEKQVE 847
Query: 295 QLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKV 354
+L + K + ++++ ++ QQ L EK+ L + L+ + + + +
Sbjct: 848 ELLMAMEK---VKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALL 904
Query: 355 SSTKSVQADRKILPFTSMRHQGTQ-----KSDVPPLTTKGKKATGNIDHKEKSTEINHEI 409
++ A+ +L +S + + + K + L + K+ T N + K N+E
Sbjct: 905 AAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQN---RMKLMADNYED 961
Query: 410 PHCVNKLPKQEDSKRKYEDLSGEEKHLEVQILLENTGRQKDKKEDQEKKNIFVKEEQEL- 468
H + Q + K + + +Q LLE +++ K +++ L
Sbjct: 962 DHFKSSHSNQTNHKPSPDQI--------IQPLLE-------LDQNRSKLKLYIGHLTTLC 1006
Query: 469 ---PPKIIEVIHPERESN-QEDVLVREKFKRSMQRNGVDDTLGKG 509
P I+ + P N +D E + M R + D L KG
Sbjct: 1007 HDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKG 1051
Score = 33.9 bits (76), Expect = 0.50
Identities = 45/202 (22%), Positives = 85/202 (42%), Gaps = 26/202 (12%)
Query: 150 KIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQNEVKN 209
+I K +L D+ K+ ++L + K+ L LK ++L K + +K
Sbjct: 618 EIDNYKKDLKDLKEKV-SLLQGDLSEKEASLLDLK------EHASSLASSGLKKDSRLKT 670
Query: 210 LRQLLRKSQEKERTLSRKLRETDSQLLKTK------DILQALQ------KLSEDKNLAER 257
L L + +E+ + +L++ L+ + D +Q L+ K K AE
Sbjct: 671 LEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEV 730
Query: 258 EELTHKLSIITTKMDANDKKIQSLEKQLR-LNCRAFSRQLAIETRKTLAAQTATK----- 311
+ L L + + + DKKI LE+Q++ N + + + + K +AQ +
Sbjct: 731 DRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRRE 790
Query: 312 -TLQVEVKHLQQKLKEKDRELE 332
L + LQ L++KD +E
Sbjct: 791 DNLNDSSQQLQDSLRKKDDRIE 812
Score = 31.6 bits (70), Expect = 2.5
Identities = 45/184 (24%), Positives = 80/184 (43%), Gaps = 18/184 (9%)
Query: 74 DCSEKAINRNYLKQPVVKEK-----EKKKYNVSKISQSKGQKEISVEKKHTWNASL---F 125
D ++K N + K+ V K+K E+ + ++ S Q + S+ KK L
Sbjct: 760 DQNKKVANLKH-KEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEAL 818
Query: 126 NSQIHMIAQRRDAMAHRILSARLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKA 185
+ + A+R +A SAR + K ++ L M E + E + +K ++
Sbjct: 819 RESVQITAEREMVLAQEE-SARTNAEKQVEELLMAM----EKVKQELESMKAKLSSTQQS 873
Query: 186 IGKYENSQNNLPQIMAKHQNEVKNLRQ--LLRKSQEKERTLSRKLRETDSQLLKTKDILQ 243
+ + E NL KH EV ++Q LL EK+ ++ L E S KT++ +
Sbjct: 874 LAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIA--LLELSSSKKKTQEEVA 931
Query: 244 ALQK 247
AL++
Sbjct: 932 ALKR 935
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 54.3 bits (129), Expect = 4e-07
Identities = 66/318 (20%), Positives = 145/318 (45%), Gaps = 52/318 (16%)
Query: 86 KQPVVKEKEKKKYNVSKISQSKGQKEISVEKK-----HTWNASLFNSQIHMIAQRRDAMA 140
KQ V++EK + + ++ +S +++ EK+ A L ++Q+ + + A +
Sbjct: 1622 KQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPS 1681
Query: 141 HRIL--------------SARLHKIKGLKNELADMHHKLEAILTE----NQFLKQLQLRH 182
R + +A + K ++ E+ D+H +++ I + L +LQ
Sbjct: 1682 KREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREK 1741
Query: 183 LKAIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDIL 242
+ + E Q ++ ++M KH+ V + L + + L +L E + + + ++ L
Sbjct: 1742 NEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQIND----LQAQLEEANKEKQELQEKL 1797
Query: 243 QALQKLSE-------DKNLAEREELTHKLSIITTKMD---ANDKKIQSLEKQLRLNCRAF 292
QALQ E DK+L R+E K+ + T+++ K+++SL +L+ N
Sbjct: 1798 QALQSQVEFLEQSMVDKSLVSRQEA--KIRELETRLEFERTQVKRLESLASRLKENMEKL 1855
Query: 293 S----RQLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDT 348
+ +++A E R+ + K LQ +++ ++++ E R+ + H + +L
Sbjct: 1856 TEERDQRIAAENRE----KEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESL 1911
Query: 349 EDYPKVSSTKSVQADRKI 366
E ++ +S+QAD K+
Sbjct: 1912 E-----AANQSLQADLKL 1924
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 53.5 bits (127), Expect = 6e-07
Identities = 59/280 (21%), Positives = 128/280 (45%), Gaps = 21/280 (7%)
Query: 185 AIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQA 244
A + Q N +I+A+ + + + + L SQ++ R+LS +L + + ++ + L+
Sbjct: 1438 AAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLET 1497
Query: 245 LQKLSEDKNLAEREELTHKLSIITTKMDANDKKIQSLEK-QLRLNCRAFSRQLAIETRKT 303
++ E+KNL E ++S +T ++ ++ K I LEK + +L Q A+E +
Sbjct: 1498 FKR--ENKNLQE------EISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEA 1549
Query: 304 LAAQTATKTLQVEVK------HLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSST 357
K L+ +++ +++KL EKD E+E R++ +L + D S
Sbjct: 1550 SLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRN 1609
Query: 358 KSVQADRKILPFTSMRHQGTQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVNKLP 417
++++ +K+ + Q S + + +K ++ K T+I + N
Sbjct: 1610 EALRVKKKM--EGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDL 1667
Query: 418 KQEDS--KRKYEDLSGEEKHLEVQILLENTGRQKDKKEDQ 455
K+ + +R+ L E + E++ ++E T R + E +
Sbjct: 1668 KENIAIVERRNNLLQAELE--ELRAVVEQTERSRKLAEQE 1705
Score = 47.8 bits (112), Expect = 3e-05
Identities = 49/268 (18%), Positives = 108/268 (40%), Gaps = 4/268 (1%)
Query: 61 LSSQYDYSEDFLCDCSEKAINRNYLKQPVVKEKEKKKYNVSKISQSKGQKEISVEKKHTW 120
L Q +D L D E+ +K + E + K+ N + + E++ +K+
Sbjct: 887 LQLQVQAEQDNLADAEERC--DQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE 944
Query: 121 NASLFNSQIHMIAQRRDAMAHRILSARLHKIKGLKNELADMHHKLEAILTENQFLKQLQL 180
+ + + A + A +K+K L E+A + + + E + L++
Sbjct: 945 DECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQ 1004
Query: 181 RHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKD 240
+ L + E+ N L + K + +V +L L + ++ L R R+ + L T++
Sbjct: 1005 QALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE 1064
Query: 241 ILQALQ--KLSEDKNLAEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAI 298
+ L+ K D+ L +++ + L+ A ++Q K+L+ +L
Sbjct: 1065 SIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEA 1124
Query: 299 ETRKTLAAQTATKTLQVEVKHLQQKLKE 326
E + L E++ + ++L+E
Sbjct: 1125 ERTARAKVEKLRSDLSRELEEISERLEE 1152
Score = 42.7 bits (99), Expect = 0.001
Identities = 50/271 (18%), Positives = 115/271 (42%), Gaps = 38/271 (14%)
Query: 87 QPVVKEKEKKKYNVSKISQSKGQKEISVEKKHTWNASLFNSQIHMIAQRRDAMAHRILSA 146
+P++K E++K S + KE ++EK L + ++ ++ D
Sbjct: 837 KPLLKSAEREKEMASMKEEFTRLKE-ALEKSEARRKELEEKMVSLLQEKNDLQL------ 889
Query: 147 RLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQNE 206
+++ ++ LAD + + ++ +N+ + +++ + + E+ + ++ AK +
Sbjct: 890 ---QVQAEQDNLADAEERCDQLI-KNKIQLEAKVKEMNE--RLEDEEEMNAELTAKKRKL 943
Query: 207 VKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQKLSE--DKNLAEREELTHKL 264
+L R + E TL++ +E + K K++ + + L E K E++ L
Sbjct: 944 EDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH 1003
Query: 265 SIITTKMDANDKKIQSL--------------------EKQLRLNCRAFSRQLAIETRKTL 304
+ A + K+ +L EK++R++ R+L + + T
Sbjct: 1004 QQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLT- 1062
Query: 305 AAQTATKTLQVEVKHLQQKLKEKDRELEIKN 335
Q + L+ + + L ++LK+KD EL N
Sbjct: 1063 --QESIMDLENDKQQLDERLKKKDFELNALN 1091
Score = 41.6 bits (96), Expect = 0.002
Identities = 60/275 (21%), Positives = 116/275 (42%), Gaps = 16/275 (5%)
Query: 70 DFLCDCSEKAINRNYLKQPVVKEKEKKKYNVSKISQSKGQ---KEISVEKKHTWNASLFN 126
D + + E+ N +KQ + KEK + K + ++ + Q + ++EK N
Sbjct: 1198 DSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMN 1257
Query: 127 SQIHMIAQRRDAMAHRILSARLHKIKGLKNELADMHHKLEAI---LTENQFLKQLQLRHL 183
H + L+++ K++ EL+ + EA+ LT + QL L
Sbjct: 1258 E--HRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDL 1315
Query: 184 K-AIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLL--KTKD 240
K + + ++N L + +++ LR+ + E + L R L + +S++ +TK
Sbjct: 1316 KRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKY 1375
Query: 241 ILQALQKLSEDKNLAEREELTHKLSIITTKMDANDKKIQSLEK-QLRLNCRAFSRQLAIE 299
A+Q+ E + +++L +L ++A + K SLEK + RL + +E
Sbjct: 1376 ETDAIQRTEELEE--AKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVE 1433
Query: 300 TRKTLAAQTATKTLQVE--VKHLQQKLKEKDRELE 332
AA K + + +QK +E ELE
Sbjct: 1434 RSNAAAAALDKKQRNFDKILAEWKQKYEESQSELE 1468
Score = 35.8 bits (81), Expect = 0.13
Identities = 47/220 (21%), Positives = 98/220 (44%), Gaps = 34/220 (15%)
Query: 68 SEDFLCDCSEKAINRNYLKQPVVKEKEKKKYNVSKI-------------SQSKGQKEIS- 113
+E L + SE+ + ++ +K+K ++S++ ++ K +K I+
Sbjct: 1702 AEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITD 1761
Query: 114 -------VEKKHTWNASLFNSQIHMIAQRRDAMAHRILSARLHKIKGLKNELADMHHKLE 166
++K+ +A L + +M +D + HR+ A +KG K +L KLE
Sbjct: 1762 AAMMAEELKKEQDTSAHLERMKKNMEQTIKD-LQHRLDEAEQIALKGGKKQL----QKLE 1816
Query: 167 AILTE-NQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQNEVKN---LRQLLRKSQEKER 222
A + E L+ Q R+ +++ S+ + ++ + + + KN L+ L+ K Q K +
Sbjct: 1817 ARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVK 1876
Query: 223 TLSRKLRETDSQ----LLKTKDILQALQKLSEDKNLAERE 258
R+ E + Q L K + + L + E ++AE +
Sbjct: 1877 AYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQ 1916
>gi|216548091 leucine zipper protein 1 [Homo sapiens]
Length = 1076
Score = 53.5 bits (127), Expect = 6e-07
Identities = 112/480 (23%), Positives = 196/480 (40%), Gaps = 76/480 (15%)
Query: 150 KIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIG-------KYENSQNNLPQIMAK 202
K++ L L ++ + + L LQ + ++A G + E + + +I K
Sbjct: 19 KLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGK 78
Query: 203 HQNEVKNLRQLLRKSQEK---ERTLSRKLRETDSQLLKTKDILQALQK-LSEDKN----- 253
+ E+K L R +EK E L+R+L+ +L K L+ L++ S KN
Sbjct: 79 DE-EIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQL 137
Query: 254 ---LAEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTAT 310
L E LT K+S + K+++S E +L + LA E K ++ T
Sbjct: 138 CLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKT----EQSLASELEK---LKSLT 190
Query: 311 KTLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKILPFT 370
+ E K+L + KEK+ E IK + + ++ +N DY + +S L
Sbjct: 191 LSFVSERKYLNE--KEKENEKLIKEL-TQKLEQNKKMNRDYTRNASN---------LERN 238
Query: 371 SMRHQGTQKSDVPPLTTKGKKATGNIDH-KEKSTEINHEIPHCVNKLPKQEDSKRKYEDL 429
+R + S +P +K + G +D+ K+ E ++ + N+ QED+K K DL
Sbjct: 239 DLRIEDGISSTLP---SKESRRKGGLDYLKQVENETRNKSENEKNR--NQEDNKVK--DL 291
Query: 430 SGEEKHLEVQI-----LLENTGRQKDKKED--------QEKKNIFVKEEQELPPKIIEVI 476
+ E + L+ QI L E + K K D Q K + + +E+ +I +
Sbjct: 292 NQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQK 351
Query: 477 HPER-ESNQEDVLVREKFKRSMQR---NGVDDTLGKGTA----PYTKGPLRQRRHYSFTE 528
E E ED + K + + +G + ++ K TA P K + R ++
Sbjct: 352 ELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNN 411
Query: 529 ATENLHHGLPASGG-----PANAGNMRYSHSTGKHLSNREEMELEHSDSGYEPSFGKSSR 583
+L + +S A A +M S +G + + E + G S GK SR
Sbjct: 412 ENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTE---DRFVPGSSQSEGKKSR 468
>gi|216548085 leucine zipper protein 1 [Homo sapiens]
Length = 1076
Score = 53.5 bits (127), Expect = 6e-07
Identities = 112/480 (23%), Positives = 196/480 (40%), Gaps = 76/480 (15%)
Query: 150 KIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIG-------KYENSQNNLPQIMAK 202
K++ L L ++ + + L LQ + ++A G + E + + +I K
Sbjct: 19 KLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGK 78
Query: 203 HQNEVKNLRQLLRKSQEK---ERTLSRKLRETDSQLLKTKDILQALQK-LSEDKN----- 253
+ E+K L R +EK E L+R+L+ +L K L+ L++ S KN
Sbjct: 79 DE-EIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQL 137
Query: 254 ---LAEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTAT 310
L E LT K+S + K+++S E +L + LA E K ++ T
Sbjct: 138 CLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKT----EQSLASELEK---LKSLT 190
Query: 311 KTLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKILPFT 370
+ E K+L + KEK+ E IK + + ++ +N DY + +S L
Sbjct: 191 LSFVSERKYLNE--KEKENEKLIKEL-TQKLEQNKKMNRDYTRNASN---------LERN 238
Query: 371 SMRHQGTQKSDVPPLTTKGKKATGNIDH-KEKSTEINHEIPHCVNKLPKQEDSKRKYEDL 429
+R + S +P +K + G +D+ K+ E ++ + N+ QED+K K DL
Sbjct: 239 DLRIEDGISSTLP---SKESRRKGGLDYLKQVENETRNKSENEKNR--NQEDNKVK--DL 291
Query: 430 SGEEKHLEVQI-----LLENTGRQKDKKED--------QEKKNIFVKEEQELPPKIIEVI 476
+ E + L+ QI L E + K K D Q K + + +E+ +I +
Sbjct: 292 NQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQK 351
Query: 477 HPER-ESNQEDVLVREKFKRSMQR---NGVDDTLGKGTA----PYTKGPLRQRRHYSFTE 528
E E ED + K + + +G + ++ K TA P K + R ++
Sbjct: 352 ELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNN 411
Query: 529 ATENLHHGLPASGG-----PANAGNMRYSHSTGKHLSNREEMELEHSDSGYEPSFGKSSR 583
+L + +S A A +M S +G + + E + G S GK SR
Sbjct: 412 ENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTE---DRFVPGSSQSEGKKSR 468
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 53.5 bits (127), Expect = 6e-07
Identities = 85/440 (19%), Positives = 185/440 (42%), Gaps = 41/440 (9%)
Query: 185 AIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQA 244
A + Q N +I+A+ + + + + L SQ++ R+LS +L + + ++ + L+
Sbjct: 1440 AAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLET 1499
Query: 245 LQKLSEDKNLAEREELTHKLSIITTKMDANDKKIQSLEK-QLRLNCRAFSRQLAIETRKT 303
++ E+KNL E ++S +T ++ K + LEK + +L Q A+E +
Sbjct: 1500 FKR--ENKNLQE------EISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEA 1551
Query: 304 LAAQTATKTLQVEVK------HLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSST 357
K L+ +++ +++KL EKD E+E R++ +L + D S
Sbjct: 1552 SLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRN 1611
Query: 358 KSVQADRKILPFTSMRHQGTQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVNKLP 417
+ ++ +K+ + Q S + + +K ++ K T+I + N
Sbjct: 1612 EVLRVKKKM--EGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDL 1669
Query: 418 KQEDS--KRKYEDLSGEEKHLEVQILLENTGRQKDKKEDQ------------EKKNIFVK 463
K+ + +R+ L E + E++ ++E T R + E + + +
Sbjct: 1670 KENIAIVERRNNLLQAELE--ELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLIN 1727
Query: 464 EEQELPPKIIEVIHPERESNQEDVLVREKFKRSMQRNG-VDDTLGKGTAPYTKGPLRQRR 522
+++++ + ++ E+ QE EK K+++ + + L K T L +R
Sbjct: 1728 QKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKK--EQDTSAHL-ERM 1784
Query: 523 HYSFTEATENLHHGLPASGGPANAGNMRYSHSTGKHLSNRE-EMELEHSDSGYEPSFGKS 581
+ + ++L H L + A G + + E E+E E + +
Sbjct: 1785 KKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRK 1844
Query: 582 SRIKVKDTTFR---DKKSSL 598
S ++K+ T++ DKK+ L
Sbjct: 1845 SERRIKELTYQTEEDKKNLL 1864
Score = 44.3 bits (103), Expect = 4e-04
Identities = 81/420 (19%), Positives = 162/420 (38%), Gaps = 55/420 (13%)
Query: 61 LSSQYDYSEDFLCDCSEKAINRNYLKQPVVKEKEKKKYNVSKISQSKGQKEISVEKKHTW 120
L Q +D L D E+ +K + E + K+ N + + E++ +K+
Sbjct: 889 LQLQVQAEQDNLNDAEERC--DQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE 946
Query: 121 N-ASLFNSQIHMIAQRRDAMAHRILSARLHKIKGLKNELADMHHKLEAILTENQFLKQLQ 179
+ S I + + A + A +K+K L E+A + + + E + L++
Sbjct: 947 DECSELKKDIDDL-ELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH 1005
Query: 180 LRHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTK 239
+ L + E+ N+L + K + +V +L L + ++ L R R+ + L T+
Sbjct: 1006 QQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ 1065
Query: 240 DILQALQKLSEDKNLAEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIE 299
+ + MD + K+Q EK + + IE
Sbjct: 1066 ESI----------------------------MDLENDKLQLEEKLKKKEFDINQQNSKIE 1097
Query: 300 TRKTLAAQTATKTLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHD--------TEDY 351
+ LA Q LQ ++K Q +++E + ELE + ++ K D +E
Sbjct: 1098 DEQVLALQ-----LQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 1152
Query: 352 PKVSSTKSVQAD---RKILPFTSMRHQGTQKSDVPPLTTKGKKATGNIDHKEKSTEINHE 408
+ SVQ + ++ F MR + + L + A H + E+ +
Sbjct: 1153 EEAGGATSVQIEMNKKREAEFQKMRRDLEEAT----LQHEATAAALRKKHADSVAELGEQ 1208
Query: 409 IPHCVNKLPKQEDSKRKYE-DLSGEEKHLEVQILLENTGRQKDKKEDQEKKNIF-VKEEQ 466
I + K E K +++ +L ++E QI+ +K + +++ N + VK E+
Sbjct: 1209 IDNLQRVKQKLEKEKSEFKLELDDVTSNME-QIIKAKANLEKVSRTLEDQANEYRVKLEE 1267
Score = 42.7 bits (99), Expect = 0.001
Identities = 85/438 (19%), Positives = 179/438 (40%), Gaps = 29/438 (6%)
Query: 70 DFLCDCSEKAINRNYLKQPVVKEKEKKKYNVSKISQSKGQ---KEISVEK-KHTWNASLF 125
D + + E+ N +KQ + KEK + K + ++ + Q + ++EK T
Sbjct: 1200 DSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQAN 1259
Query: 126 NSQIHMIAQRRDAMAHRILSARLHKIKGLKNELADMHHKLEAI---LTENQFLKQLQLRH 182
++ + +R A+L G ELA + EA+ LT + Q+
Sbjct: 1260 EYRVKLEEAQRSLNDFTTQRAKLQTENG---ELARQLEEKEALISQLTRGKLSYTQQMED 1316
Query: 183 LK-AIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLL--KTK 239
LK + + ++N L + +++ LR+ + E + L R L + +S++ +TK
Sbjct: 1317 LKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTK 1376
Query: 240 DILQALQKLSEDKNLAEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIE 299
A+Q+ E + +++L +L ++A + K SLEK + + L ++
Sbjct: 1377 YETDAIQRTEELEE--AKKKLAQRLQDAEEAVEAVNAKCSSLEK-TKHRLQNEIEDLMVD 1433
Query: 300 TRKTLAAQTATKTLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKS 359
++ AA A Q + + K+K E + + S + ++L ++ K+
Sbjct: 1434 VERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLS-----TELFKLKN 1488
Query: 360 VQADRKILPFTSMRHQGTQKSDVPPLTTKGKKATGNIDHKEK-STEINHEIPHCVNKLPK 418
+ T R + ++ LT + + N+ EK ++ E + L +
Sbjct: 1489 AYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEE 1548
Query: 419 QEDSKRKYED--LSGEEKHLEVQILLENTGRQKDKKEDQEKKNIFVKEEQELPPKIIEVI 476
E S E L + + +++ +E +KD++ +Q K+N Q + + +
Sbjct: 1549 AEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRN-----HQRVVDSLQTSL 1603
Query: 477 HPERESNQEDVLVREKFK 494
E S E + V++K +
Sbjct: 1604 DAETRSRNEVLRVKKKME 1621
Score = 36.2 bits (82), Expect = 0.10
Identities = 45/201 (22%), Positives = 88/201 (43%), Gaps = 15/201 (7%)
Query: 87 QPVVKEKEKKKYNVSKISQSKGQKEISVEKKHTWNASLFNSQIHMIAQRRDAMAHRILSA 146
+ V+E + K ++K+ +A L + +M +D + HR+ A
Sbjct: 1744 EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKD-LQHRLDEA 1802
Query: 147 RLHKIKGLKNELADMHHKLEAILTENQ-FLKQLQLRHLKAIGKYENSQNNLPQIMAKHQN 205
+KG K +L KLEA + E + L+ Q R+ +++ S+ + ++ + +
Sbjct: 1803 EQIALKGGKKQL----QKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEE 1858
Query: 206 EVKN---LRQLLRKSQEKERTLSRKLRETDSQ----LLKTKDILQALQKLSEDKNLAERE 258
+ KN L+ L+ K Q K + R+ E + Q L K + + L + E ++AE +
Sbjct: 1859 DKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQ 1918
Query: 259 --ELTHKLSIITTKMDANDKK 277
+L K I K +D++
Sbjct: 1919 VNKLRAKSRDIGAKQKMHDEE 1939
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.126 0.344
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,995,991
Number of Sequences: 37866
Number of extensions: 1185733
Number of successful extensions: 7729
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 93
Number of HSP's successfully gapped in prelim test: 725
Number of HSP's that attempted gapping in prelim test: 5695
Number of HSP's gapped (non-prelim): 2056
length of query: 670
length of database: 18,247,518
effective HSP length: 109
effective length of query: 561
effective length of database: 14,120,124
effective search space: 7921389564
effective search space used: 7921389564
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.