Search of human proteins with 225543094

Search of human proteins with 225543094

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo
sapiens]
         (403 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]      855   0.0  
gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [H...   855   0.0  
gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]    525   e-149
gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]    476   e-134
gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]   467   e-132
gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]   439   e-123
gi|73858572 matrix metalloproteinase 12 preproprotein [Homo sapi...   427   e-120
gi|73808268 matrix metalloproteinase 27 [Homo sapiens]                415   e-116
gi|45359865 matrix metalloproteinase 20 preproprotein [Homo sapi...   384   e-106
gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]   296   2e-80
gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein ...   283   2e-76
gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]   268   5e-72
gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]   266   2e-71
gi|58331148 matrix metalloproteinase 11 preproprotein [Homo sapi...   248   9e-66
gi|112382270 matrix metalloproteinase 17 preproprotein [Homo sap...   232   4e-61
gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]    224   8e-59
gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]      218   1e-56
gi|11342666 matrix metalloproteinase 2 isoform a preproprotein [...   218   1e-56
gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein...   205   5e-53
gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprot...   204   1e-52
gi|11968059 matrix metalloproteinase 25 preproprotein [Homo sapi...   201   7e-52
gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein ...   191   1e-48
gi|73808266 matrix metalloproteinase 26 preproprotein [Homo sapi...   169   3e-42
gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]   161   9e-40
gi|22218341 matrix metalloproteinase 21 preproprotein [Homo sapi...   124   1e-28
gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens]          113   3e-25
gi|169203660 PREDICTED: similar to hCG2042634 [Homo sapiens]          113   3e-25
gi|169202084 PREDICTED: similar to hCG2042634 [Homo sapiens]          113   3e-25
gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]      107   2e-23
gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo ...    80   3e-15

>gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]
          Length = 403

 Score =  855 bits (2210), Expect = 0.0
 Identities = 403/403 (100%), Positives = 403/403 (100%)

Query: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 60
           MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP
Sbjct: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 60

Query: 61  RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 120
           RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ
Sbjct: 61  RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 120

Query: 121 PGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDV 180
           PGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDV
Sbjct: 121 PGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDV 180

Query: 181 QLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTN 240
           QLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTN
Sbjct: 181 QLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTN 240

Query: 241 PFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYS 300
           PFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYS
Sbjct: 241 PFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYS 300

Query: 301 SFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKV 360
           SFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKV
Sbjct: 301 SFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKV 360

Query: 361 DAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN 403
           DAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
Sbjct: 361 DAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN 403


>gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [Homo
           sapiens]
          Length = 469

 Score =  855 bits (2210), Expect = 0.0
 Identities = 403/403 (100%), Positives = 403/403 (100%)

Query: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 60
           MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP
Sbjct: 67  MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 126

Query: 61  RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 120
           RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ
Sbjct: 127 RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 186

Query: 121 PGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDV 180
           PGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDV
Sbjct: 187 PGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDV 246

Query: 181 QLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTN 240
           QLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTN
Sbjct: 247 QLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTN 306

Query: 241 PFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYS 300
           PFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYS
Sbjct: 307 PFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYS 366

Query: 301 SFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKV 360
           SFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKV
Sbjct: 367 SFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKV 426

Query: 361 DAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN 403
           DAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
Sbjct: 427 DAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN 469


>gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]
          Length = 467

 Score =  525 bits (1352), Expect = e-149
 Identities = 246/403 (61%), Positives = 306/403 (75%), Gaps = 5/403 (1%)

Query: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 60
           MQ FFGL VTGKP+ ETL +MK+PRCGVPD   F+LT GNP+WE+T+LTYRI NYTP L 
Sbjct: 66  MQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLS 125

Query: 61  RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 120
            A+V+ AI+ AF+LWS  +PL FT++S+G+ADI I+F + DH DNSPFDGP G LAHAFQ
Sbjct: 126 EAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQ 185

Query: 121 PGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTF--SG 178
           PG GIGGDAHFD +E WTN    YNL  VAAHE GHSLGL+HS+D GALMYP+Y F  + 
Sbjct: 186 PGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETS 245

Query: 179 DVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMR 238
           +  L QDDIDGIQAIYG S NP+QP GP TPK CD  LTFDAITT+RGE++FFKDR++ R
Sbjct: 246 NYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWR 305

Query: 239 TNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDI 298
            +P    VE+NFIS+FWP LP G++AAYE  DRD +  FKGN+YWA+ G ++L GYPKDI
Sbjct: 306 RHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDI 365

Query: 299 YSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGH 358
            S++GFP +V+ IDAA+   +  KTYFFV +++WRYD  ++ M+PGYPK I+  FPGI  
Sbjct: 366 -SNYGFPSSVQAIDAAVFYRS--KTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIES 422

Query: 359 KVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCR 401
           KVDAVF ++ FF+ F G R Y FD   +R+  + + N W NCR
Sbjct: 423 KVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCR 465


>gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]
          Length = 477

 Score =  476 bits (1224), Expect = e-134
 Identities = 228/412 (55%), Positives = 298/412 (72%), Gaps = 13/412 (3%)

Query: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 60
           MQ+F GL+VTGK D++TL+VM++PRCGVPDV  F    G P+W +THLTYRI NYTPDLP
Sbjct: 67  MQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLP 126

Query: 61  RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 120
           +  VD A+EKA ++W  VTPLTF+++ EG+ADIMISF   +H D  PFDGPG  LAHA+ 
Sbjct: 127 KDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYA 186

Query: 121 PGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDV 180
           PGPGI GDAHFD+DE+WT +    NL  VAAHE+GHSLGL HS +  ALMYP Y    D+
Sbjct: 187 PGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDL 246

Query: 181 ---QLAQDDIDGIQAIYGRSQN-------PVQPIGPQ--TPKACDSKLTFDAITTIRGEV 228
              +L+QDDI+GIQ++YG   +       P +P+ P+  TP  CD  L+FDA++T+RGE+
Sbjct: 247 TRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEI 306

Query: 229 MFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQ 288
           + FKDR + R +    E EL+ IS FWP LP+G++AAYE   +D V  FKGN++WA++G 
Sbjct: 307 LIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGN 366

Query: 289 NVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKM 348
            V  GYP+ I+ + GFP TV+ IDAA+S++   KTYFFV +KYWR+DE + SM+PG+PK 
Sbjct: 367 EVRAGYPRGIH-TLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQ 425

Query: 349 IAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNC 400
           IA DFPGI  K+DAVF + GFFYFF G+ Q +FDP  K++    K+NSW NC
Sbjct: 426 IAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC 477


>gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]
          Length = 476

 Score =  467 bits (1201), Expect = e-132
 Identities = 223/412 (54%), Positives = 295/412 (71%), Gaps = 13/412 (3%)

Query: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 60
           MQ+F GL+VTGK D +TL+VM++PRCGVPDV  F    G P+W +THLTYRI NYTPDLP
Sbjct: 66  MQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNYTPDLP 125

Query: 61  RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 120
           R  VD AIEKA ++W  VTPLTF+++ EG+ADIMISF   +H D   FDGPG +LAHA+ 
Sbjct: 126 RDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSLAHAYP 185

Query: 121 PGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYP---SYTFS 177
           PGPG+ GD HFD+DE+WT +    NL  VAAHELGHSLGL HS +  ALMYP   S+T  
Sbjct: 186 PGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTEL 245

Query: 178 GDVQLAQDDIDGIQAIYG----RSQNPVQPI-----GPQTPKACDSKLTFDAITTIRGEV 228
              +L+QDD++GIQ++YG     ++ P+ P      G + P  CD  L+FDAI+T+RGE 
Sbjct: 246 AQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAISTLRGEY 305

Query: 229 MFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQ 288
           +FFKDR++ R + + PE E + IS FWP LP+ L+AAYE   RD V  FKGN++WA++G 
Sbjct: 306 LFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGN 365

Query: 289 NVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKM 348
            V  GYP+ I+ + GFP T++ IDAA+S++   KTYFF A+KYWR+DE  +SM+ G+P++
Sbjct: 366 EVQAGYPRGIH-TLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRL 424

Query: 349 IAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNC 400
           IA DFPG+  KVDAV    GFFYFF G+ Q++FDP  + +  + K+NSW +C
Sbjct: 425 IADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC 476


>gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]
          Length = 471

 Score =  439 bits (1130), Expect = e-123
 Identities = 211/402 (52%), Positives = 274/402 (68%), Gaps = 3/402 (0%)

Query: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 60
           MQ FFGL+VTGK D  TL VMK+PRCGVPDV ++ +     +W + +LTYRI NYTPD+ 
Sbjct: 71  MQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMT 130

Query: 61  RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 120
            ++V+ A +KAF++WS+VTPL FT++ +G ADIMISF   +H D  PFDGP G LAHAF 
Sbjct: 131 HSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFP 190

Query: 121 PGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSG-- 178
           PGP  GGDAHFD+DE WT++ + YNL  VAAHE GHSLGL HS D GALM+P YT++G  
Sbjct: 191 PGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKS 250

Query: 179 DVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMR 238
              L  DD+ GIQ++YG       P  P+TP  CD  L+ DAIT++RGE M FKDRF+ R
Sbjct: 251 HFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWR 310

Query: 239 TNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDI 298
            +P   + EL     FWP+LPN ++AAYE    D +  F+G K+WA+ G ++L GYPK I
Sbjct: 311 LHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKI 370

Query: 299 YSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGH 358
            S  G P+ VK I AA+  E+TGKT  F  N+ WRYD+    MD  YP++I  DFPGIG 
Sbjct: 371 -SELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGD 429

Query: 359 KVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNC 400
           KVDAV+ K+G+ YFF+G  Q+++   + RI+ +  ANS   C
Sbjct: 430 KVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC 471


>gi|73858572 matrix metalloproteinase 12 preproprotein [Homo
           sapiens]
          Length = 470

 Score =  427 bits (1099), Expect = e-120
 Identities = 211/405 (52%), Positives = 270/405 (66%), Gaps = 6/405 (1%)

Query: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 60
           MQ F GLKVTG+ D  TL++M  PRCGVPDV  F    G P W + ++TYRI NYTPD+ 
Sbjct: 67  MQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINNYTPDMN 126

Query: 61  RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 120
           R DVD+AI KAFQ+WSNVTPL F+K++ G ADI++ F RG H D   FDG GG LAHAF 
Sbjct: 127 REDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFG 186

Query: 121 PGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTF--SG 178
           PG GIGGDAHFDEDE WT +    NL   A HE+GHSLGL HS+D  A+M+P+Y +    
Sbjct: 187 PGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDIN 246

Query: 179 DVQLAQDDIDGIQAIYGRSQNPVQPIGPQT--PKACDSKLTFDAITTIRGEVMFFKDRFY 236
             +L+ DDI GIQ++YG  +   +   P    P  CD  L+FDA+TT+  ++ FFKDRF+
Sbjct: 247 TFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFFFKDRFF 306

Query: 237 MRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPK 296
                  P+  +N IS  WP LP+G+EAAYE   R++V  FK +KYW +        YPK
Sbjct: 307 WLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPNYPK 366

Query: 297 DIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGI 356
            I+ SFGFP  VK IDAA+      +TYFFV N+YWRYDE ++ MDPGYPK+I  +F GI
Sbjct: 367 SIH-SFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNFQGI 425

Query: 357 GHKVDAVF-MKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNC 400
           G K+DAVF  K+ ++YFF G+ Q+++D   +RI    K+NSWF C
Sbjct: 426 GPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC 470


>gi|73808268 matrix metalloproteinase 27 [Homo sapiens]
          Length = 513

 Score =  415 bits (1066), Expect = e-116
 Identities = 214/406 (52%), Positives = 271/406 (66%), Gaps = 8/406 (1%)

Query: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 60
           MQ FFGL VTGK D+ TL++MK PRCGVPDV Q+  T   P W + +LTYRI NYTPD+ 
Sbjct: 66  MQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVGQYGYTL--PGWRKYNLTYRIINYTPDMA 123

Query: 61  RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDH-RDNSPFDGPGGNLAHAF 119
           RA VD AI++  ++WS VTPL FTK+S+G ADIMI+F    H R    FDGP G L HAF
Sbjct: 124 RAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDGPLGVLGHAF 183

Query: 120 QPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGD 179
            PGPG+GGD HFDEDE WT +   +NL  VAAHE GH+LGLSHS D  ALM+P+Y     
Sbjct: 184 PPGPGLGGDTHFDEDENWTKDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLDP 243

Query: 180 VQ--LAQDDIDGIQAIYGR-SQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFY 236
            +  L+QDDI+GIQ+IYG   + P +P  P  P ACD  LTFDAITT R EVMFFK R  
Sbjct: 244 RKYPLSQDDINGIQSIYGGLPKEPAKPKEPTIPHACDPDLTFDAITTFRREVMFFKGRHL 303

Query: 237 MRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPK 296
            R      +VE   I+ FWP LP  L+AAYE   RD++  FK   +W ++G  VL  YPK
Sbjct: 304 WRIYYDITDVEFELIASFWPSLPADLQAAYE-NPRDKILVFKDENFWMIRGYAVLPDYPK 362

Query: 297 DIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGI 356
            I++  GFP  VK IDAA+ ++ T KTYFFV    WR+DE  ++MD G+P+ +   FPGI
Sbjct: 363 SIHT-LGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPGI 421

Query: 357 GHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRK 402
             +VDA F   GFF+F  G++Q+++D KTK I  + + N+WF C++
Sbjct: 422 SIRVDAAFQYKGFFFFSRGSKQFEYDIKTKNITRIMRTNTWFQCKE 467


>gi|45359865 matrix metalloproteinase 20 preproprotein [Homo
           sapiens]
          Length = 483

 Score =  384 bits (985), Expect = e-106
 Identities = 191/411 (46%), Positives = 260/411 (63%), Gaps = 13/411 (3%)

Query: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 60
           +Q FFGL+VTGK D  T+ V+K+PRCGVPDVA + L  G P+W++  LTYRI  YTP + 
Sbjct: 75  LQAFFGLQVTGKLDQTTMNVIKKPRCGVPDVANYRLFPGEPKWKKNTLTYRISKYTPSMS 134

Query: 61  RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 120
             +VD A+E A Q WS+  PL+F +++ G+ADIMISF  GDH D+ PFDGP G LAHAF 
Sbjct: 135 SVEVDKAVEMALQAWSSAVPLSFVRINSGEADIMISFENGDHGDSYPFDGPRGTLAHAFA 194

Query: 121 PGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSG-- 178
           PG G+GGD HFD  E+WT     +NL  VAAHE GH+LGL+HSTD  ALMYP+Y +    
Sbjct: 195 PGEGLGGDTHFDNAEKWTMGTNGFNLFTVAAHEFGHALGLAHSTDPSALMYPTYKYKNPY 254

Query: 179 DVQLAQDDIDGIQAIYGRSQ----NPVQPIG----PQTPKACDSKLTFDAITTIRGEVMF 230
              L +DD+ GIQA+YG  +     P  P      P  P  CDS  +FDA+T +  E++ 
Sbjct: 255 GFHLPKDDVKGIQALYGPRKVFLGKPTLPHAPHHKPSIPDLCDSSSSFDAVTMLGKELLL 314

Query: 231 FKDR-FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQN 289
           FKDR F+ R       +  + I+  +PQL + ++AAYE A+R    FFKG  YW  +G  
Sbjct: 315 FKDRIFWRRQVHLRTGIRPSTITSSFPQLMSNVDAAYEVAERGTAYFFKGPHYWITRGFQ 374

Query: 290 VLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMI 349
            + G P+ IY  FGFPR V+ IDAA+      KT FFV ++Y+ YDE KR M+  YPK  
Sbjct: 375 -MQGPPRTIY-DFGFPRHVQQIDAAVYLREPQKTLFFVGDEYYSYDERKRKMEKDYPKNT 432

Query: 350 AHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNC 400
             +F G+  ++DA    +G+ YFF G + YK+D + + ++++ K++SW  C
Sbjct: 433 EEEFSGVNGQIDAAVELNGYIYFFSGPKTYKYDTEKEDVVSVVKSSSWIGC 483


>gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]
          Length = 645

 Score =  296 bits (759), Expect = 2e-80
 Identities = 183/440 (41%), Positives = 229/440 (52%), Gaps = 63/440 (14%)

Query: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPR-------WEQTHLTYRIE 53
           MQ+F+G+ VTG  D  T++ MK+PRCGVPD         N R       W Q H+TY I 
Sbjct: 114 MQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIH 173

Query: 54  NYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKV-------SEGQADIMISFVRGDHRDNS 106
           NYTP +   D   AI +AF +W  VTPLTF +V          +ADIMI F  G H D+S
Sbjct: 174 NYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSS 233

Query: 107 PFDGPGGNLAHAFQPGPGIGGDAHFDEDERWT---NNFREYNLHRVAAHELGHSLGLSHS 163
           PFDG GG LAHA+ PGPGIGGD HFD DE WT    N    +L  VA HELGH+LGL HS
Sbjct: 234 PFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHS 293

Query: 164 TDIGALMYPSYTF--SGDVQLAQDDIDGIQAIYGRSQNPVQPIGP--------------- 206
           +D  A+M P Y +  + + +L QDD+ GIQ IYG    P++P  P               
Sbjct: 294 SDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSER 353

Query: 207 ---------------------QTPKACDSKLTFDAITTIRGEVMFFKDRFYMR-TNPFYP 244
                                  P  CD    F+ +   RGE+  FKDR++ R  N    
Sbjct: 354 KHERQPRPPRPPLGDRPSTPGTKPNICDG--NFNTVALFRGEMFVFKDRWFWRLRNNRVQ 411

Query: 245 EVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGF 304
           E     I  FW  LP  ++AAYE AD   V FFKG+KYW  +   V  GYP  +    G 
Sbjct: 412 EGYPMQIEQFWKGLPARIDAAYERADGRFV-FFKGDKYWVFKEVTVEPGYPHSL-GELGS 469

Query: 305 PRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVF 364
               + ID AL  E  GKTYFF   +YWRY E +R+ DPGYPK I   + GI       F
Sbjct: 470 CLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPIT-VWKGIPQAPQGAF 528

Query: 365 M-KDGFF-YFFHGTRQYKFD 382
           + K+G++ YF+ G   +KFD
Sbjct: 529 ISKEGYYTYFYKGRDYWKFD 548


>gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein
           [Homo sapiens]
          Length = 607

 Score =  283 bits (724), Expect = 2e-76
 Identities = 173/450 (38%), Positives = 238/450 (52%), Gaps = 70/450 (15%)

Query: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQ-----------FVLTEGNPRWEQTHLT 49
           MQ+F+G+ +TGK D  T+  MK+PRCGVPD  +           + LT    +W+  H+T
Sbjct: 76  MQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALT--GQKWQHKHIT 133

Query: 50  YRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQ-------ADIMISFVRGDH 102
           Y I+N TP +   +   AI +AF +W NVTPLTF +V   +        DI I F  G H
Sbjct: 134 YSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFH 193

Query: 103 RDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWT---NNFREYNLHRVAAHELGHSLG 159
            D+SPFDG GG LAHA+ PGPGIGGD HFD DE WT    N    +L  VA HELGH+LG
Sbjct: 194 GDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALG 253

Query: 160 LSHSTDIGALMYPSYTF--SGDVQLAQDDIDGIQAIYG---------------------- 195
           L HS D  A+M P Y +  + + +L  DD+ GIQ IYG                      
Sbjct: 254 LEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIP 313

Query: 196 ----RSQNPVQPIGPQT---------PKACDSKLTFDAITTIRGEVMFFKDRFY--MRTN 240
               R  +  +P  P T         P  CD    F+ +  +R E+  FKD+++  +R N
Sbjct: 314 PADPRKNDRPKPPRPPTGRPSYPGAKPNICDG--NFNTLAILRREMFVFKDQWFWRVRNN 371

Query: 241 PFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYS 300
                  +  I+ FW  LP  ++A YE +D + V FFKGNKYW  +   +  GYP D+  
Sbjct: 372 RVMDGYPMQ-ITYFWRGLPPSIDAVYENSDGNFV-FFKGNKYWVFKDTTLQPGYPHDLI- 428

Query: 301 SFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKV 360
           + G       ID+A+  E+ GKTYFF  ++YWRY E  ++MDPGYPK I   + GI    
Sbjct: 429 TLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPIT-VWKGIPESP 487

Query: 361 DAVFM--KDGFFYFFHGTRQYKFDPKTKRI 388
              F+  ++GF YF+ G   +KF+ +  ++
Sbjct: 488 QGAFVHKENGFTYFYKGKEYWKFNNQILKV 517


>gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]
          Length = 582

 Score =  268 bits (686), Expect = 5e-72
 Identities = 172/435 (39%), Positives = 228/435 (52%), Gaps = 56/435 (12%)

Query: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPD---------VAQFVLTEGNPRWEQTHLTYR 51
           MQ+F+GL+VTGK DA+T+K M++PRCGVPD         V +        +W+   +T+ 
Sbjct: 68  MQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFC 127

Query: 52  IENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVS--------EGQADIMISFVRGDHR 103
           I+NYTP +       AI KAF++W + TPL F +V         E QADIMI F  G H 
Sbjct: 128 IQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHG 187

Query: 104 DNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYN---LHRVAAHELGHSLGL 160
           D++PFDG GG LAHA+ PGP IGGD HFD  E WT    + N   +  VA HELGH+LGL
Sbjct: 188 DSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGL 247

Query: 161 SHSTDIGALMYPSYTF--SGDVQLAQDDIDGIQAIYG-----------------RSQNPV 201
            HS+D  A+M P Y +  + +  L  DD  GIQ +YG                 R   P 
Sbjct: 248 EHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPD 307

Query: 202 QPIGP-QTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTN-----PFYPEVELNFISVFW 255
           +P  P   P  CD    FD +  +RGE+  FK+R++ R         YP      I  FW
Sbjct: 308 KPKNPTYGPNICDG--NFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMP----IGQFW 361

Query: 256 PQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAAL 315
             LP  +  AYE  D   V FFKG+K+W     ++  GYPK I    G       IDAAL
Sbjct: 362 RGLPASINTAYERKDGKFV-FFKGDKHWVFDEASLEPGYPKHI-KELGRGLPTDKIDAAL 419

Query: 316 SEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFM--KDGFFYFF 373
                GKTYFF  NKY+R++E  R++D  YPK I   + GI       FM   + F YF+
Sbjct: 420 FWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNI-KVWEGIPESPRGSFMGSDEVFTYFY 478

Query: 374 HGTRQYKFDPKTKRI 388
            G + +KF+ +  ++
Sbjct: 479 KGNKYWKFNNQKLKV 493


>gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]
          Length = 669

 Score =  266 bits (680), Expect = 2e-71
 Identities = 173/468 (36%), Positives = 237/468 (50%), Gaps = 89/468 (19%)

Query: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQF-VLTEGNPR------------WEQTH 47
           MQ F+G+ VTG  D ET + MK+PRCGVPD  QF V  + N R            W   H
Sbjct: 86  MQRFYGIPVTGVLDEETKEWMKRPRCGVPD--QFGVRVKANLRRRRKRYALTGRKWNNHH 143

Query: 48  LTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVS--------EGQADIMISFVR 99
           LT+ I+NYT  L       A+ +AF++W   TPL F +V         + +ADIM+ F  
Sbjct: 144 LTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFAS 203

Query: 100 GDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWT---NNFREYNLHRVAAHELGH 156
           G H D+SPFDG GG LAHA+ PGPG+GGD HFD DE WT    +    NL  VA HELGH
Sbjct: 204 GFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGH 263

Query: 157 SLGLSHSTDIGALMYPSYTFS--GDVQLAQDDIDGIQAIYG------------------- 195
           +LGL HS++  A+M P Y +    + +L +DD+ GIQ +YG                   
Sbjct: 264 ALGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRR 323

Query: 196 ----------------------RSQNPVQPIGPQT--------PKACDSKLTFDAITTIR 225
                                 R   P  P+ P+         P  CD    FD +  +R
Sbjct: 324 PGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDG--DFDTVAMLR 381

Query: 226 GEVMFFKDRFYMRTNPFYPEVELNF---ISVFWPQLPNGLEAAYEFADRDEVRFFKGNKY 282
           GE+  FK R++ R    +  V  N+   I  FW  LP  + AAYE  D   V FFKG++Y
Sbjct: 382 GEMFVFKGRWFWRVR--HNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFV-FFKGDRY 438

Query: 283 WAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMD 342
           W  +  N+  GYP+ + +S+G       ID A+  E TG T+FF  ++YWR++E  +  D
Sbjct: 439 WLFREANLEPGYPQPL-TSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGD 497

Query: 343 PGYPKMIAHDFPGIGHKVDAVFMKD--GFFYFFHGTRQYKFDPKTKRI 388
           PGYPK I+  + GI       F+ +   + YF+ GT+ +KFD +  R+
Sbjct: 498 PGYPKPIS-VWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRM 544


>gi|58331148 matrix metalloproteinase 11 preproprotein [Homo
           sapiens]
          Length = 488

 Score =  248 bits (632), Expect = 9e-66
 Identities = 159/399 (39%), Positives = 215/399 (53%), Gaps = 49/399 (12%)

Query: 21  MKQPRCGVPDVA----------QFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEK 70
           ++ PRCGVPD +          +FVL+ G  RWE+T LTYRI  +   L +  V   + +
Sbjct: 75  LRPPRCGVPDPSDGLSARNRQKRFVLSGG--RWEKTDLTYRILRFPWQLVQEQVRQTMAE 132

Query: 71  AFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAH 130
           A ++WS+VTPLTFT+V EG+ADIMI F R  H D+ PFDGPGG LAHAF P     GD H
Sbjct: 133 ALKVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVH 192

Query: 131 FDEDERWT-NNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDG 189
           FD DE WT  + +  +L +VAAHE GH LGL H+T   ALM   YTF   + L+ DD  G
Sbjct: 193 FDYDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRG 252

Query: 190 IQAIYGR------------------SQNPVQPIGPQT-PKACDSKLTFDAITTIRGEVMF 230
           +Q +YG+                    N + P+ P   P AC++  +FDA++TIRGE+ F
Sbjct: 253 VQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEA--SFDAVSTIRGELFF 310

Query: 231 FKDRFYMR-----TNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAV 285
           FK  F  R       P YP +     S  W  LP+ ++AA+E A +  + FF+G +YW  
Sbjct: 311 FKAGFVWRLRGGQLQPGYPAL----ASRHWQGLPSPVDAAFEDA-QGHIWFFQGAQYWVY 365

Query: 286 QGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGY 345
            G+  + G P  + +  G  R   H       E   K YFF    YWR+    R +D   
Sbjct: 366 DGEKPVLG-PAPL-TELGLVRFPVHAALVWGPEK-NKIYFFRGRDYWRFHPSTRRVDSPV 422

Query: 346 PKMIAHDFPGIGHKVDAVFM-KDGFFYFFHGTRQYKFDP 383
           P+  A D+ G+  ++DA F   DG+ YF  G   +KFDP
Sbjct: 423 PRR-ATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDP 460


>gi|112382270 matrix metalloproteinase 17 preproprotein [Homo
           sapiens]
          Length = 603

 Score =  232 bits (592), Expect = 4e-61
 Identities = 156/424 (36%), Positives = 214/424 (50%), Gaps = 52/424 (12%)

Query: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPR--------WEQTHLTYRI 52
           MQ+F GL+ TG  D  TL +MK PRC +PD+   VLT+   R        W + +L++R+
Sbjct: 85  MQQFGGLEATGILDEATLALMKTPRCSLPDLP--VLTQARRRRQAPAPTKWNKRNLSWRV 142

Query: 53  ENYTPDLPRAD--VDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDG 110
             +  D P     V   +  A ++WS++ PL F +V+   ADI I F + DH D  PFDG
Sbjct: 143 RTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDGYPFDG 202

Query: 111 PGGNLAHAFQPG-PGIGGDAHFDEDERWTNNFREYNLH-----RVAAHELGHSLGLSHST 164
           PGG +AHAF PG     GD HFD+DE WT  FR  + H      VA HE GH++GLSH  
Sbjct: 203 PGGTVAHAFFPGHHHTAGDTHFDDDEAWT--FRSSDAHGMDLFAVAVHEFGHAIGLSHVA 260

Query: 165 DIGALMYPSYTFS-GD---VQLAQDDIDGIQAIYG-------RSQNPVQPIGPQTPKACD 213
              ++M P Y    GD     L  +D   +  +YG        +Q    P+ P+ P    
Sbjct: 261 AAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESVSPTAQPEEPPLLPEPPDNRS 320

Query: 214 S-----------KLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISV--FWPQLP- 259
           S              FDA+  IRGE  FFK +++ R       V L    +  FW  LP 
Sbjct: 321 SAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPL 380

Query: 260 --NGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSE 317
             + ++A YE     ++ FFKG++YW  +  NV  GYP+ + S F  P     IDAA S 
Sbjct: 381 HLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPV-SDFSLP--PGGIDAAFSW 437

Query: 318 ENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKV-DAVFMKDGFFYFFHGT 376
            +  +TYFF    YWRYD++ R MDPGYP   +  + G+   + DA+   DG  YFF G 
Sbjct: 438 AHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQ-SPLWRGVPSTLDDAMRWSDGASYFFRGQ 496

Query: 377 RQYK 380
             +K
Sbjct: 497 EYWK 500


>gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]
          Length = 267

 Score =  224 bits (572), Expect = 8e-59
 Identities = 110/203 (54%), Positives = 139/203 (68%), Gaps = 5/203 (2%)

Query: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 60
           MQ+FFGL +TG  ++  +++M++PRCGVPDVA++ L   +P+W    +TYRI +YT DLP
Sbjct: 62  MQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLP 121

Query: 61  RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 120
              VD  + KA  +W    PL F KV  G ADIMI F RG H D+ PFDGPG  LAHAF 
Sbjct: 122 HITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFA 181

Query: 121 PGPGIGGDAHFDEDERWTN-NFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGD 179
           PG G+GGDAHFDEDERWT+ +    N    A HELGHSLG+ HS+D  A+MYP+Y  +GD
Sbjct: 182 PGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYG-NGD 240

Query: 180 VQ---LAQDDIDGIQAIYGRSQN 199
            Q   L+QDDI GIQ +YG+  N
Sbjct: 241 PQNFKLSQDDIKGIQKLYGKRSN 263


>gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]
          Length = 610

 Score =  218 bits (554), Expect = 1e-56
 Identities = 115/285 (40%), Positives = 162/285 (56%), Gaps = 16/285 (5%)

Query: 129 AHFDEDERWTNNF---REYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQD 185
           A++D+D +W   F   + Y+L  VAAHE GH++GL HS D GALM P YT++ + +L+QD
Sbjct: 329 ANYDDDRKW--GFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQD 386

Query: 186 DIDGIQAIYGRSQN------PVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRT 239
           DI GIQ +YG S +      P   +GP TP+ C   + FD I  IRGE+ FFKDRF  RT
Sbjct: 387 DIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRT 446

Query: 240 -NPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDI 298
             P    +    ++ FWP+LP  ++A YE    ++  FF GN+YW      +  GYPK +
Sbjct: 447 VTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPL 506

Query: 299 YSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGH 358
            +S G P  V+ +DAA +     KTY F  +K+WRY+E K+ MDPG+PK+IA  +  I  
Sbjct: 507 -TSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPD 565

Query: 359 KVDAV--FMKDGFFYFFHGTRQYKFDPKTKRILTLQKANS-WFNC 400
            +DAV      G  YFF G    K + ++ + +      S W  C
Sbjct: 566 NLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC 610



 Score =  170 bits (431), Expect = 2e-42
 Identities = 76/138 (55%), Positives = 99/138 (71%)

Query: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 60
           MQ+FFGL  TG  D  T++ M++PRCG PDVA +      P+W++  +TYRI  YTPDL 
Sbjct: 27  MQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLD 86

Query: 61  RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 120
              VD A  +AFQ+WS+VTPL F+++ +G+ADIMI+F R +H D  PFDG  G LAHAF 
Sbjct: 87  PETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFA 146

Query: 121 PGPGIGGDAHFDEDERWT 138
           PG G+GGD+HFD+DE WT
Sbjct: 147 PGTGVGGDSHFDDDELWT 164


>gi|11342666 matrix metalloproteinase 2 isoform a preproprotein
           [Homo sapiens]
          Length = 660

 Score =  218 bits (554), Expect = 1e-56
 Identities = 115/285 (40%), Positives = 162/285 (56%), Gaps = 16/285 (5%)

Query: 129 AHFDEDERWTNNF---REYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQD 185
           A++D+D +W   F   + Y+L  VAAHE GH++GL HS D GALM P YT++ + +L+QD
Sbjct: 379 ANYDDDRKW--GFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQD 436

Query: 186 DIDGIQAIYGRSQN------PVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRT 239
           DI GIQ +YG S +      P   +GP TP+ C   + FD I  IRGE+ FFKDRF  RT
Sbjct: 437 DIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRT 496

Query: 240 -NPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDI 298
             P    +    ++ FWP+LP  ++A YE    ++  FF GN+YW      +  GYPK +
Sbjct: 497 VTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPL 556

Query: 299 YSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGH 358
            +S G P  V+ +DAA +     KTY F  +K+WRY+E K+ MDPG+PK+IA  +  I  
Sbjct: 557 -TSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPD 615

Query: 359 KVDAV--FMKDGFFYFFHGTRQYKFDPKTKRILTLQKANS-WFNC 400
            +DAV      G  YFF G    K + ++ + +      S W  C
Sbjct: 616 NLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC 660



 Score =  170 bits (431), Expect = 2e-42
 Identities = 76/138 (55%), Positives = 99/138 (71%)

Query: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 60
           MQ+FFGL  TG  D  T++ M++PRCG PDVA +      P+W++  +TYRI  YTPDL 
Sbjct: 77  MQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLD 136

Query: 61  RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 120
              VD A  +AFQ+WS+VTPL F+++ +G+ADIMI+F R +H D  PFDG  G LAHAF 
Sbjct: 137 PETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFA 196

Query: 121 PGPGIGGDAHFDEDERWT 138
           PG G+GGD+HFD+DE WT
Sbjct: 197 PGTGVGGDSHFDDDELWT 214


>gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein
           [Homo sapiens]
          Length = 457

 Score =  205 bits (522), Expect = 5e-53
 Identities = 130/338 (38%), Positives = 174/338 (51%), Gaps = 66/338 (19%)

Query: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQ-----------FVLTEGNPRWEQTHLT 49
           MQ+F+G+ +TGK D  T+  MK+PRCGVPD  +           + LT    +W+  H+T
Sbjct: 76  MQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALT--GQKWQHKHIT 133

Query: 50  YRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQ-------ADIMISFVRGDH 102
           Y I+N TP +   +   AI +AF +W NVTPLTF +V   +        DI I F  G H
Sbjct: 134 YSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFH 193

Query: 103 RDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWT---NNFREYNLHRVAAHELGHSLG 159
            D+SPFDG GG LAHA+ PGPGIGGD HFD DE WT    N    +L  VA HELGH+LG
Sbjct: 194 GDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALG 253

Query: 160 LSHSTDIGALMYPSYTF--SGDVQLAQDDIDGIQAIYG---------------------- 195
           L HS D  A+M P Y +  + + +L  DD+ GIQ IYG                      
Sbjct: 254 LEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIP 313

Query: 196 ----RSQNPVQPIGPQT---------PKACDSKLTFDAITTIRGEVMFFKDRFY--MRTN 240
               R  +  +P  P T         P  CD    F+ +  +R E+  FKD+++  +R N
Sbjct: 314 PADPRKNDRPKPPRPPTGRPSYPGAKPNICDG--NFNTLAILRREMFVFKDQWFWRVRNN 371

Query: 241 PFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFK 278
                  +  I+ FW  LP  ++A YE +D + V FFK
Sbjct: 372 RVMDGYPMQ-ITYFWRGLPPSIDAVYENSDGNFV-FFK 407



 Score = 29.3 bits (64), Expect = 6.6
 Identities = 19/51 (37%), Positives = 26/51 (50%), Gaps = 3/51 (5%)

Query: 324 YFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVF-MKDGFFYFF 373
           + F    +WR     R MD GYP  I + + G+   +DAV+   DG F FF
Sbjct: 358 FVFKDQWFWRVRN-NRVMD-GYPMQITYFWRGLPPSIDAVYENSDGNFVFF 406


>gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprotein
           [Homo sapiens]
          Length = 508

 Score =  204 bits (518), Expect = 1e-52
 Identities = 151/428 (35%), Positives = 210/428 (49%), Gaps = 43/428 (10%)

Query: 2   QEFFGLKVTGKPDAETLKVMKQPRCGVPD-----VAQFVLTEGNPRWEQTHLTYRIENYT 56
           QE   L V+G+ D  T   M+QPRCG+ D       +++L     RW + HLT+RI N  
Sbjct: 61  QEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLG---RWRKKHLTFRILNLP 117

Query: 57  PDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISF-VRGDHRDNSPFDGPGGNL 115
             LP      A+ +AFQ WSNV PLTF +V  G ADI +SF  R     ++ FDGPG  L
Sbjct: 118 STLPPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVL 177

Query: 116 AHAFQPGPGIGGDAHFDEDERWT-NNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY 174
           AHA  P     G  HFDEDE WT   +R  NL  +AAHE+GH+LGL HS    ALM P Y
Sbjct: 178 AHADIPEL---GSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVY 234

Query: 175 T-FSGDVQLAQDDIDGIQAIYGR------------SQNPVQPIGPQTPK----ACDSKLT 217
             +    +L  DD+ GIQA+YG+            ++ P  P  P  P      C S+L 
Sbjct: 235 EGYRPHFKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSEL- 293

Query: 218 FDAITT-IRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRF 276
            DA+    RG+   FK  +    +   P   L  +S  W  LP  L+AA        + F
Sbjct: 294 -DAMMLGPRGKTYAFKGDYVWTVSDSGPG-PLFRVSALWEGLPGNLDAAVYSPRTQWIHF 351

Query: 277 FKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDE 336
           FKG+K W      +  G+PK +       R   ++DAAL      K + F  + YW++DE
Sbjct: 352 FKGDKVWRYINFKMSPGFPKKL------NRVEPNLDAALYWPLNQKVFLFKGSGYWQWDE 405

Query: 337 YKRSMDPGYPKMIAHDFPGIGHKVDAVF-MKDGFFYFFHGTRQYKFDP--KTKRILTLQK 393
             R+    YPK I   F G+ ++  A    +DG  YFF G   ++ +   + ++      
Sbjct: 406 LARTDFSSYPKPIKGLFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQQLRVEKGYPRNI 465

Query: 394 ANSWFNCR 401
           +++W +CR
Sbjct: 466 SHNWMHCR 473


>gi|11968059 matrix metalloproteinase 25 preproprotein [Homo
           sapiens]
          Length = 562

 Score =  201 bits (512), Expect = 7e-52
 Identities = 149/449 (33%), Positives = 207/449 (46%), Gaps = 54/449 (12%)

Query: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPR--------WEQTHLTYRI 52
           MQ F GL  TG+ D  T+  M++PRC +PDV          R        W++  LT+R+
Sbjct: 65  MQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTLTWRV 124

Query: 53  ENY--TPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQA---DIMISFVRGDHRDNSP 107
            ++  +  L +  V   +  A   W   + LTF +V   Q    DI+I F R  H+D+ P
Sbjct: 125 RSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQDSYP 184

Query: 108 FDGPGGNLAHAFQPGP-GIGGDAHFDEDERWTNNFRE---YNLHRVAAHELGHSLGLSHS 163
           FDG GG LAHAF PG   I GD HFD++E WT   ++    +L  VA HE GH+LGL HS
Sbjct: 185 FDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHS 244

Query: 164 TDIGALMYPSYTFS-GD---VQLAQDDIDGIQAIYGRSQN-------------PVQPIGP 206
           +   ++M P Y    GD    +L+QDD DG+Q +YG++               P QP   
Sbjct: 245 SAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQPPAS 304

Query: 207 QT-------PKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELN--FISVFWPQ 257
            T       P  C+    FDAI  IRGE  FFK  ++ R  P    V      +  FW  
Sbjct: 305 PTHSPSFPIPDRCEG--NFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEG 362

Query: 258 LP---NGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAA 314
           LP     ++AAY       +  F G ++W  Q +  L G  + + +  G P   + +DA 
Sbjct: 363 LPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQ-LEGGARPL-TELGLP-PGEEVDAV 419

Query: 315 LSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFH 374
            S    GKTY     +YWRYDE     DPGYP+ ++          D      G  YFF 
Sbjct: 420 FSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSPDDVTVSNAGDTYFFK 479

Query: 375 GTRQYKFDP---KTKRILTLQKANSWFNC 400
           G   ++F     KT+         +W +C
Sbjct: 480 GAHYWRFPKNSIKTEPDAPQPMGPNWLDC 508


>gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein
           [Homo sapiens]
          Length = 520

 Score =  191 bits (484), Expect = 1e-48
 Identities = 146/429 (34%), Positives = 207/429 (48%), Gaps = 64/429 (14%)

Query: 7   LKVTGKPDAETLKVMKQPRCGVPDVAQFVL-----------------------TEGNPRW 43
           L V+G  D  TL+ M +PRCGV D   +                          +GN +W
Sbjct: 72  LPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRKKRFAKQGN-KW 130

Query: 44  EQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKV-SEGQADIMISFVRGDH 102
            + HL+YR+ N+   LP   V  A+  AFQLWSNV+ L F +  + G ADI ++F +GDH
Sbjct: 131 YKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQGDH 190

Query: 103 RD--NSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWT-NNFREYNLHRVAAHELGHSLG 159
            D   + FDGPGG LAHAF P     G+AHFD+DERW+ +  R  NL  V AHE+GH+LG
Sbjct: 191 NDGLGNAFDGPGGALAHAFLPR---RGEAHFDQDERWSLSRRRGRNLFVVLAHEIGHTLG 247

Query: 160 LSHSTDIGALMYPSYTFSG-DVQLAQDDIDGIQAIYGR-------------------SQN 199
           L+HS    ALM P Y   G D  L+ DD+  +Q++YG+                   + +
Sbjct: 248 LTHSPAPRALMAPYYKRLGRDALLSWDDVLAVQSLYGKPLGGSVAVQLPGKLFTDFETWD 307

Query: 200 PVQPIG--PQT--PKACDSKLTFDAITTIRGEVMF-FKDRFYMRTNPFYPEVELNFISVF 254
              P G  P+T  PK C S  +FDAIT  R + ++ FK   +          E   +   
Sbjct: 308 SYSPQGRRPETQGPKYCHS--SFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPRPLQER 365

Query: 255 WPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAA 314
           W  LP  +EAA    +  +  FFKG + W  +G   + G P+ +  + G PR   H DAA
Sbjct: 366 WVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQ-LCRAGGLPR---HPDAA 421

Query: 315 LSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMK-DGFFYFF 373
           L      +   F   +Y+        ++P YP+ +  D+ GI  +V     + DG   FF
Sbjct: 422 LFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSL-QDWGGIPEEVSGALPRPDGSIIFF 480

Query: 374 HGTRQYKFD 382
              R ++ D
Sbjct: 481 RDDRYWRLD 489


>gi|73808266 matrix metalloproteinase 26 preproprotein [Homo
           sapiens]
          Length = 261

 Score =  169 bits (429), Expect = 3e-42
 Identities = 85/184 (46%), Positives = 112/184 (60%), Gaps = 2/184 (1%)

Query: 14  DAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQ 73
           D +   ++ QP CGVPD +   ++ G  +W +  LTYRI NY  D+  + V  +I  A  
Sbjct: 70  DMQMHALLHQPHCGVPDGSDTSISPGRCKWNKHTLTYRIINYPHDMKPSAVKDSIYNAVS 129

Query: 74  LWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDE 133
           +WSNVTPL F +V  G ADI +SF +  H D  PFDGPGG L HAF P  G  G  HFD+
Sbjct: 130 IWSNVTPLIFQQVQNGDADIKVSFWQWAHEDGWPFDGPGGILGHAFLPNSGNPGVVHFDK 189

Query: 134 DERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSG--DVQLAQDDIDGIQ 191
           +E W+ +   YNL  VA HE+GHSLGL HS +  ++MYP+Y +      QL+ DDI  IQ
Sbjct: 190 NEHWSASDTGYNLFLVATHEIGHSLGLQHSGNQSSIMYPTYWYHDPRTFQLSADDIQRIQ 249

Query: 192 AIYG 195
            +YG
Sbjct: 250 HLYG 253


>gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]
          Length = 707

 Score =  161 bits (408), Expect = 9e-40
 Identities = 76/138 (55%), Positives = 96/138 (69%)

Query: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 60
           +Q+   L  TG+ D+ TLK M+ PRCGVPD+ +F   EG+ +W   ++TY I+NY+ DLP
Sbjct: 74  LQKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHNITYWIQNYSEDLP 133

Query: 61  RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 120
           RA +D A  +AF LWS VTPLTFT+V    ADI+I F   +H D  PFDG  G LAHAF 
Sbjct: 134 RAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFP 193

Query: 121 PGPGIGGDAHFDEDERWT 138
           PGPGI GDAHFD+DE W+
Sbjct: 194 PGPGIQGDAHFDDDELWS 211



 Score =  100 bits (249), Expect = 2e-21
 Identities = 89/314 (28%), Positives = 129/314 (41%), Gaps = 81/314 (25%)

Query: 129 AHFDEDERWTNNF---REYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQD 185
           ++FD D++W   F   + Y+L  VAAHE GH+LGL HS+   ALMYP Y F+    L +D
Sbjct: 377 SNFDSDKKW--GFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKD 434

Query: 186 DIDGIQAIYGRSQNP-----------------VQPIGPQT-------------------- 208
           D++GI+ +YG    P                 V P GP T                    
Sbjct: 435 DVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAGPT 494

Query: 209 --PKACDSKLT---------------FDAITTIRGEVMFFKDRFYMR------TNPFYPE 245
             P A  S  T               FDAI  I  ++  FKD  Y R      + P  P 
Sbjct: 495 GPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYWRFSEGRGSRPQGPF 554

Query: 246 VELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFP 305
           +    I+  WP LP  L++ +E     ++ FF G + W   G +VL   P+ +    G  
Sbjct: 555 L----IADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLG--PRRL-DKLGLG 607

Query: 306 RTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGI--------G 357
             V  +  AL     GK   F   + WR+D   + +DP     +   FPG+         
Sbjct: 608 ADVAQVTGAL-RSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLDTHDVFQ 666

Query: 358 HKVDAVFMKDGFFY 371
           ++  A F +D F++
Sbjct: 667 YREKAYFCQDRFYW 680


>gi|22218341 matrix metalloproteinase 21 preproprotein [Homo
           sapiens]
          Length = 569

 Score =  124 bits (312), Expect = 1e-28
 Identities = 124/440 (28%), Positives = 174/440 (39%), Gaps = 112/440 (25%)

Query: 7   LKVTGKPDAETLKVMKQPRCGVPDVAQ--------------FVLTEGNPR---------W 43
           L  +G+ DA TL  M +PRCGVPD+                   +  +PR         W
Sbjct: 98  LPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGW 157

Query: 44  E--------------QTHLTYRI--ENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTK-- 85
           +              +  L++R+  E  +  L  AD    +  AF++WS VTPL F +  
Sbjct: 158 QPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDL 217

Query: 86  VSEGQA-DIMISFVRGDHRD-NSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFRE 143
            + G A DI + F RG H      FDG G   AHA++ G     D HFD+DE +T    +
Sbjct: 218 AAPGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRLG-----DIHFDDDEHFTPPTSD 272

Query: 144 --YNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDV-QLAQDDIDGIQAIYGRSQNP 200
              +L +VA HE+GH LGL H+   G++M P+Y       +L   D   IQ +YG  +  
Sbjct: 273 TGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEPAFELDWSDRKAIQKLYGSCEGS 332

Query: 201 VQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPN 260
                            FD I   R +               Y EV + F          
Sbjct: 333 FD-------------TAFDWIRKERNQ---------------YGEVMVRF---------- 354

Query: 261 GLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKH-IDAALS--E 317
                          FF+ + YW  + +N    Y   I    G+P    H IDA +    
Sbjct: 355 ------------STYFFRNSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWT 402

Query: 318 ENTGKTYFFVANKYWRYDEYK------RSMDPGYPKMIAHDFPGIGHKVDAVF--MKDGF 369
               + YFF  N+YWRYD  K            YPK+I+  FPGI   +D  F   +   
Sbjct: 403 WKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKL 462

Query: 370 FYFFHGTRQYKFDPKTKRIL 389
            YFF  +  + FD    R+L
Sbjct: 463 IYFFKESLVFAFDVNRNRVL 482


>gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 358

 Score =  113 bits (282), Expect = 3e-25
 Identities = 54/92 (58%), Positives = 68/92 (73%), Gaps = 3/92 (3%)

Query: 270 DRDEVRF--FKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFV 327
           D DE R   F+ +K+W VQ   +L GYP+D+YSSF FP  VK IDAA+ E++TGKT+FFV
Sbjct: 267 DNDETRTKDFRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFV 326

Query: 328 ANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHK 359
           AN+YWRYDE  +S+D GYPK+I  D PGI  K
Sbjct: 327 ANEYWRYDENMQSVDAGYPKII-DDLPGISKK 357



 Score =  112 bits (281), Expect = 5e-25
 Identities = 55/91 (60%), Positives = 65/91 (71%), Gaps = 1/91 (1%)

Query: 53  ENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFV-RGDHRDNSPFDGP 111
           +NY P+LP+ DVD A  KAF+LWSN + LTFT+  E + DI++SFV   D  DNSPF G 
Sbjct: 187 QNYMPNLPQEDVDRATGKAFELWSNASALTFTRDFESEGDIILSFVFLADLHDNSPFYGH 246

Query: 112 GGNLAHAFQPGPGIGGDAHFDEDERWTNNFR 142
            G LAHAF PGPGIGGD HFD DE  T +FR
Sbjct: 247 DGCLAHAFPPGPGIGGDVHFDNDETRTKDFR 277



 Score = 29.6 bits (65), Expect = 5.1
 Identities = 17/51 (33%), Positives = 25/51 (49%), Gaps = 2/51 (3%)

Query: 250 FISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQG--QNVLHGYPKDI 298
           + S  +P+    ++AA    D  +  FF  N+YW      Q+V  GYPK I
Sbjct: 298 YSSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDENMQSVDAGYPKII 348


>gi|169203660 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 198

 Score =  113 bits (282), Expect = 3e-25
 Identities = 57/105 (54%), Positives = 70/105 (66%), Gaps = 7/105 (6%)

Query: 39  GNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFV 98
           G  +W++       +NY P+LP+ DVD A  KAF+LWSN + LTFT+  E + DI++SFV
Sbjct: 19  GIQKWQED------QNYMPNLPQEDVDRATGKAFELWSNASALTFTRDFESEGDIILSFV 72

Query: 99  -RGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFR 142
              D  DNSPF G  G LAHAF PGPGIGGD HFD DE  T +FR
Sbjct: 73  FLADLHDNSPFYGHDGCLAHAFPPGPGIGGDVHFDNDETRTKDFR 117



 Score =  113 bits (282), Expect = 3e-25
 Identities = 54/92 (58%), Positives = 68/92 (73%), Gaps = 3/92 (3%)

Query: 270 DRDEVRF--FKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFV 327
           D DE R   F+ +K+W VQ   +L GYP+D+YSSF FP  VK IDAA+ E++TGKT+FFV
Sbjct: 107 DNDETRTKDFRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFV 166

Query: 328 ANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHK 359
           AN+YWRYDE  +S+D GYPK+I  D PGI  K
Sbjct: 167 ANEYWRYDENMQSVDAGYPKII-DDLPGISKK 197



 Score = 29.6 bits (65), Expect = 5.1
 Identities = 17/51 (33%), Positives = 25/51 (49%), Gaps = 2/51 (3%)

Query: 250 FISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQG--QNVLHGYPKDI 298
           + S  +P+    ++AA    D  +  FF  N+YW      Q+V  GYPK I
Sbjct: 138 YSSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDENMQSVDAGYPKII 188


>gi|169202084 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 198

 Score =  113 bits (282), Expect = 3e-25
 Identities = 54/92 (58%), Positives = 68/92 (73%), Gaps = 3/92 (3%)

Query: 270 DRDEVRF--FKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFV 327
           D DE R   F+ +K+W VQ   +L GYP+D+YSSF FP  VK IDAA+ E++TGKT+FFV
Sbjct: 107 DNDETRTKDFRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFV 166

Query: 328 ANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHK 359
           AN+YWRYDE  +S+D GYPK+I  D PGI  K
Sbjct: 167 ANEYWRYDENMQSVDAGYPKII-DDLPGISKK 197



 Score =  110 bits (276), Expect = 2e-24
 Identities = 56/105 (53%), Positives = 69/105 (65%), Gaps = 7/105 (6%)

Query: 39  GNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFV 98
           G  +W++       +NY P+LP+ DVD A  KAF+LWS  + LTFT+  E + DI++SFV
Sbjct: 19  GIQKWQED------QNYMPNLPQEDVDRATGKAFELWSKASALTFTRDFESEGDIILSFV 72

Query: 99  -RGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFR 142
              D  DNSPF G  G LAHAF PGPGIGGD HFD DE  T +FR
Sbjct: 73  FLADLHDNSPFYGHDGCLAHAFPPGPGIGGDVHFDNDETRTKDFR 117



 Score = 29.6 bits (65), Expect = 5.1
 Identities = 17/51 (33%), Positives = 25/51 (49%), Gaps = 2/51 (3%)

Query: 250 FISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQG--QNVLHGYPKDI 298
           + S  +P+    ++AA    D  +  FF  N+YW      Q+V  GYPK I
Sbjct: 138 YSSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDENMQSVDAGYPKII 188


>gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]
          Length = 390

 Score =  107 bits (267), Expect = 2e-23
 Identities = 70/185 (37%), Positives = 101/185 (54%), Gaps = 22/185 (11%)

Query: 29  PDVAQFVLTEGNPRWEQTHLTYRIENYTPDL--PRADVDHAIEKAFQLWSNVTPLTFTKV 86
           P   ++ LT    RW+  +LTYRI ++  +L  PR +   A+  AF++WS+V+P +F +V
Sbjct: 74  PRRRRYTLTPARLRWDHFNLTYRILSFPRNLLSPR-ETRRALAAAFRMWSDVSPFSFREV 132

Query: 87  SEGQ-ADIMISFVRGDHRD------NSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTN 139
           +  Q +D+ I F   +H D      +  FDGP G LAHAF P  G     HFD+ E W  
Sbjct: 133 APEQPSDLRIGFYPINHTDCLVSALHHCFDGPTGELAHAFFPPHG---GIHFDDSEYWVL 189

Query: 140 NFREYN---------LHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGI 190
               Y+         L  VAAHE+GH+LGL HS    ALM+ + T  G   L+QD++ G+
Sbjct: 190 GPTRYSWKKGVWLTDLVHVAAHEIGHALGLMHSQHGRALMHLNATLRGWKALSQDELWGL 249

Query: 191 QAIYG 195
             +YG
Sbjct: 250 HRLYG 254


>gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo
           sapiens]
          Length = 183

 Score = 80.1 bits (196), Expect = 3e-15
 Identities = 50/117 (42%), Positives = 65/117 (55%), Gaps = 9/117 (7%)

Query: 2   QEFFGLKVTGKPDAETLKVMKQPRCGVPD-----VAQFVLTEGNPRWEQTHLTYRIENYT 56
           QE   L V+G+ D  T   M+QPRCG+ D       +++L     RW + HLT+RI N  
Sbjct: 61  QEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLG---RWRKKHLTFRILNLP 117

Query: 57  PDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISF-VRGDHRDNSPFDGPG 112
             LP      A+ +AFQ WSNV PLTF +V  G ADI +SF  R     ++ FDGPG
Sbjct: 118 STLPPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPG 174


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.139    0.443 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,157,461
Number of Sequences: 37866
Number of extensions: 819072
Number of successful extensions: 1720
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 1449
Number of HSP's gapped (non-prelim): 86
length of query: 403
length of database: 18,247,518
effective HSP length: 105
effective length of query: 298
effective length of database: 14,271,588
effective search space: 4252933224
effective search space used: 4252933224
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.