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Search of human proteins with 221554549
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|221554549 calpain 8 [Homo sapiens]
(703 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|221554549 calpain 8 [Homo sapiens] 1446 0.0
gi|157389005 calpain 2 isoform 1 [Homo sapiens] 920 0.0
gi|12408656 calpain 1, large subunit [Homo sapiens] 864 0.0
gi|225703100 calpain 2 isoform 2 [Homo sapiens] 820 0.0
gi|215490104 calpain 11 [Homo sapiens] 739 0.0
gi|27765074 calpain 3 isoform c [Homo sapiens] 723 0.0
gi|5729758 calpain 9 isoform 1 [Homo sapiens] 722 0.0
gi|7705383 calpain 9 isoform 2 [Homo sapiens] 684 0.0
gi|27765072 calpain 3 isoform b [Homo sapiens] 649 0.0
gi|4557405 calpain 3 isoform a [Homo sapiens] 646 0.0
gi|47078247 calpain 3 isoform f [Homo sapiens] 617 e-177
gi|38707981 calpain 12 [Homo sapiens] 535 e-152
gi|223468608 calpain 14 [Homo sapiens] 457 e-128
gi|37577157 calpain 5 [Homo sapiens] 349 6e-96
gi|41152101 calpain 13 [Homo sapiens] 331 2e-90
gi|13186316 calpain 6 [Homo sapiens] 290 2e-78
gi|13186302 calpain 10 isoform a [Homo sapiens] 230 3e-60
gi|27765076 calpain 3 isoform d [Homo sapiens] 223 6e-58
gi|89353291 calpain 10 isoform c [Homo sapiens] 218 2e-56
gi|14161692 calpain small subunit 2 [Homo sapiens] 159 8e-39
gi|5032105 small optic lobes [Homo sapiens] 155 1e-37
gi|4502565 calpain, small subunit 1 [Homo sapiens] 150 3e-36
gi|51599151 calpain, small subunit 1 [Homo sapiens] 150 3e-36
gi|27765080 calpain 3 isoform e [Homo sapiens] 141 2e-33
gi|27765078 calpain 3 isoform e [Homo sapiens] 141 2e-33
gi|38679884 sorcin isoform b [Homo sapiens] 99 2e-20
gi|4507207 sorcin isoform a [Homo sapiens] 99 2e-20
gi|7656959 calpain 7 [Homo sapiens] 92 1e-18
gi|6912388 grancalcin, EF-hand calcium binding protein [Homo sap... 92 2e-18
gi|7019485 programmed cell death 6 [Homo sapiens] 65 2e-10
>gi|221554549 calpain 8 [Homo sapiens]
Length = 703
Score = 1446 bits (3743), Expect = 0.0
Identities = 703/703 (100%), Positives = 703/703 (100%)
Query: 1 MAAQAAGVSRQRAATQGLGSNQNALKYLGQDFKTLRQQCLDSGVLFKDPEFPACPSALGY 60
MAAQAAGVSRQRAATQGLGSNQNALKYLGQDFKTLRQQCLDSGVLFKDPEFPACPSALGY
Sbjct: 1 MAAQAAGVSRQRAATQGLGSNQNALKYLGQDFKTLRQQCLDSGVLFKDPEFPACPSALGY 60
Query: 61 KDLGPGSPQTQGIIWKRPTELCPSPQFIVGGATRTDICQGGLGDCWLLAAIASLTLNEEL 120
KDLGPGSPQTQGIIWKRPTELCPSPQFIVGGATRTDICQGGLGDCWLLAAIASLTLNEEL
Sbjct: 61 KDLGPGSPQTQGIIWKRPTELCPSPQFIVGGATRTDICQGGLGDCWLLAAIASLTLNEEL 120
Query: 121 LYRVVPRDQDFQENYAGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSAL 180
LYRVVPRDQDFQENYAGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSAL
Sbjct: 121 LYRVVPRDQDFQENYAGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSAL 180
Query: 181 LEKAYAKLNGCYEALAGGSTVEGFEDFTGGISEFYDLKKPPANLYQIIRKALCAGSLLGC 240
LEKAYAKLNGCYEALAGGSTVEGFEDFTGGISEFYDLKKPPANLYQIIRKALCAGSLLGC
Sbjct: 181 LEKAYAKLNGCYEALAGGSTVEGFEDFTGGISEFYDLKKPPANLYQIIRKALCAGSLLGC 240
Query: 241 SIDVSSAAEAEAITSQKLVKSHAYSVTGVEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDD 300
SIDVSSAAEAEAITSQKLVKSHAYSVTGVEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDD
Sbjct: 241 SIDVSSAAEAEAITSQKLVKSHAYSVTGVEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDD 300
Query: 301 APEWNHIDPRRKEELDKKVEDGEFWMSLSDFVRQFSRLEICNLSPDSLSSEEVHKWNLVL 360
APEWNHIDPRRKEELDKKVEDGEFWMSLSDFVRQFSRLEICNLSPDSLSSEEVHKWNLVL
Sbjct: 301 APEWNHIDPRRKEELDKKVEDGEFWMSLSDFVRQFSRLEICNLSPDSLSSEEVHKWNLVL 360
Query: 361 FNGHWTRGSTAGGCQNYPATYWTNPQFKIRLDEVDEDQEESIGEPCCTVLLGLMQKNRRW 420
FNGHWTRGSTAGGCQNYPATYWTNPQFKIRLDEVDEDQEESIGEPCCTVLLGLMQKNRRW
Sbjct: 361 FNGHWTRGSTAGGCQNYPATYWTNPQFKIRLDEVDEDQEESIGEPCCTVLLGLMQKNRRW 420
Query: 421 RKRIGQGMLSIGYAVYQVPKELESHTDAHLGRDFFLAYQPSARTSTYVNLREVSGRARLP 480
RKRIGQGMLSIGYAVYQVPKELESHTDAHLGRDFFLAYQPSARTSTYVNLREVSGRARLP
Sbjct: 421 RKRIGQGMLSIGYAVYQVPKELESHTDAHLGRDFFLAYQPSARTSTYVNLREVSGRARLP 480
Query: 481 PGEYLVVPSTFEPFKDGEFCLRVFSEKKAQALEIGDVVAGNPYEPHPSEVDQEDDQFRRL 540
PGEYLVVPSTFEPFKDGEFCLRVFSEKKAQALEIGDVVAGNPYEPHPSEVDQEDDQFRRL
Sbjct: 481 PGEYLVVPSTFEPFKDGEFCLRVFSEKKAQALEIGDVVAGNPYEPHPSEVDQEDDQFRRL 540
Query: 541 FEKLAGKDSEITANALKILLNEAFSKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEF 600
FEKLAGKDSEITANALKILLNEAFSKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEF
Sbjct: 541 FEKLAGKDSEITANALKILLNEAFSKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEF 600
Query: 601 KTLWLKIQKYLEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGI 660
KTLWLKIQKYLEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGI
Sbjct: 601 KTLWLKIQKYLEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGI 660
Query: 661 NFDSFVACMIRLETLFKLFSLLDEDKDGMVQLSLAEWLCCVLV 703
NFDSFVACMIRLETLFKLFSLLDEDKDGMVQLSLAEWLCCVLV
Sbjct: 661 NFDSFVACMIRLETLFKLFSLLDEDKDGMVQLSLAEWLCCVLV 703
>gi|157389005 calpain 2 isoform 1 [Homo sapiens]
Length = 700
Score = 920 bits (2377), Expect = 0.0
Identities = 432/699 (61%), Positives = 554/699 (79%), Gaps = 3/699 (0%)
Query: 1 MAAQAAGVSRQRAATQGLGSNQNALKYLGQDFKTLRQQCLDSGVLFKDPEFPACPSALGY 60
MA AA +++ R A +GLGS++ A+KYL QD++ LR +CL++G LF+DP FPA PSALG+
Sbjct: 1 MAGIAAKLAKDREAAEGLGSHERAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGF 60
Query: 61 KDLGPGSPQTQGIIWKRPTELCPSPQFIVGGATRTDICQGGLGDCWLLAAIASLTLNEEL 120
K+LGP S +T+GI WKRPTE+C PQFI+GGATRTDICQG LGDCWLLAAIASLTLNEE+
Sbjct: 61 KELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEI 120
Query: 121 LYRVVPRDQDFQENYAGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSAL 180
L RVVP +Q FQENYAGIFHFQFWQYGEWVEVV+DDRLPTK+G+LLF+HS +G+EFWSAL
Sbjct: 121 LARVVPLNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSAL 180
Query: 181 LEKAYAKLNGCYEALAGGSTVEGFEDFTGGISEFYDLKKPPANLYQIIRKALCAGSLLGC 240
LEKAYAK+NGCYEAL+GG+T EGFEDFTGGI+E+Y+LKKPP NL++II+KAL GSLLGC
Sbjct: 181 LEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGC 240
Query: 241 SIDVSSAAEAEAITSQKLVKSHAYSVTGVEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDD 300
SID++SAA++EAIT QKLVK HAYSVTG EEV G +KLIR+RNPWGEVEW+G W+D+
Sbjct: 241 SIDITSAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDN 300
Query: 301 APEWNHIDPRRKEELDKKVEDGEFWMSLSDFVRQFSRLEICNLSPDSLSSEEVHKWNLVL 360
P WN IDP +E L ++ EDGEFWMS SDF+R +SRLEICNL+PD+L+S+ KW L
Sbjct: 301 CPSWNTIDPEERERLTRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTK 360
Query: 361 FNGHWTRGSTAGGCQNYPATYWTNPQFKIRLDEVDEDQEESIGEPCCTVLLGLMQKNRRW 420
+G+W RGSTAGGC+NYP T+W NPQ+ I+L+E DED+E+ GE CT L+GL+QK+RR
Sbjct: 361 MDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEED--GESGCTFLVGLIQKHRRR 418
Query: 421 RKRIGQGMLSIGYAVYQVPKELESHTDAHLGRDFFLAYQPSARTSTYVNLREVSGRARLP 480
++++G+ M +IG+ +Y+VP+EL T+ HL ++FFL + R+ T++NLREV R +LP
Sbjct: 419 QRKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLP 478
Query: 481 PGEYLVVPSTFEPFKDGEFCLRVFSEKKAQALEIGDVVAGNPYEPHPSEVDQEDDQFRRL 540
PGEY++VPSTFEP KDG+FC+RVFSEKKA + D + N E SE D DD FRRL
Sbjct: 479 PGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISE-DDIDDGFRRL 537
Query: 541 FEKLAGKDSEITANALKILLNEAFSKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEF 600
F +LAG+D+EI+A L+ +L +KR DIK DGF+I TC+ M+ +LDS+G+G LG EF
Sbjct: 538 FAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEF 597
Query: 601 KTLWLKIQKYLEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGI 660
LW KIQKY +IY E D + SGT++++EMR AL +AGF + Q+ Q I R+A +L I
Sbjct: 598 YILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLII 657
Query: 661 NFDSFVACMIRLETLFKLFSLLDEDKDGMVQLSLAEWLC 699
+FD+FV C++RLETLFK+F LD + G ++L L WLC
Sbjct: 658 DFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWLC 696
>gi|12408656 calpain 1, large subunit [Homo sapiens]
Length = 714
Score = 864 bits (2233), Expect = 0.0
Identities = 406/694 (58%), Positives = 522/694 (75%)
Query: 5 AAGVSRQRAATQGLGSNQNALKYLGQDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLG 64
+A V +QRA GLG ++NA+KYLGQD++ LR +CL SG LF+D FP P +LGYKDLG
Sbjct: 15 SAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLG 74
Query: 65 PGSPQTQGIIWKRPTELCPSPQFIVGGATRTDICQGGLGDCWLLAAIASLTLNEELLYRV 124
P S +T GI WKRPTEL +PQFIV GATRTDICQG LGDCWLLAAIASLTLN+ LL+RV
Sbjct: 75 PNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRV 134
Query: 125 VPRDQDFQENYAGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKA 184
VP Q FQ YAGIFHFQ WQ+GEWV+VV+DD LP K+G+L+F+HS +GNEFWSALLEKA
Sbjct: 135 VPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKA 194
Query: 185 YAKLNGCYEALAGGSTVEGFEDFTGGISEFYDLKKPPANLYQIIRKALCAGSLLGCSIDV 244
YAK+NG YEAL+GGST EGFEDFTGG++E+Y+L+K P++LYQII KAL GSLLGCSID+
Sbjct: 195 YAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDI 254
Query: 245 SSAAEAEAITSQKLVKSHAYSVTGVEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDDAPEW 304
SS + EAIT +KLVK HAYSVTG ++VN++G LIR+RNPWGEVEW+GAWSD + EW
Sbjct: 255 SSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEW 314
Query: 305 NHIDPRRKEELDKKVEDGEFWMSLSDFVRQFSRLEICNLSPDSLSSEEVHKWNLVLFNGH 364
N++DP +++L K+EDGEFWMS DF+R+F+RLEICNL+PD+L S + KWN L+ G
Sbjct: 315 NNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEGT 374
Query: 365 WTRGSTAGGCQNYPATYWTNPQFKIRLDEVDEDQEESIGEPCCTVLLGLMQKNRRWRKRI 424
W RGSTAGGC+NYPAT+W NPQFKIRLDE D+ + E C+ +L LMQK+RR +R
Sbjct: 375 WRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRF 434
Query: 425 GQGMLSIGYAVYQVPKELESHTDAHLGRDFFLAYQPSARTSTYVNLREVSGRARLPPGEY 484
G+ M +IG+AVY+VP EL HL RDFFLA AR+ ++NLREVS R RLPPGEY
Sbjct: 435 GRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEY 494
Query: 485 LVVPSTFEPFKDGEFCLRVFSEKKAQALEIGDVVAGNPYEPHPSEVDQEDDQFRRLFEKL 544
+VVPSTFEP K+G+F LR FSEK A +E+ D + N + ++ D+ F+ LF +L
Sbjct: 495 VVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSEEEIDENFKALFRQL 554
Query: 545 AGKDSEITANALKILLNEAFSKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEFKTLW 604
AG+D EI+ L+ +LN SK D++ GF++ +CR M++L+D +G G LG VEF LW
Sbjct: 555 AGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILW 614
Query: 605 LKIQKYLEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGINFDS 664
+I+ YL I+ + D + SG++ A+EMR A+ AGF LN ++ + I RY+ L ++FD+
Sbjct: 615 NRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDN 674
Query: 665 FVACMIRLETLFKLFSLLDEDKDGMVQLSLAEWL 698
FV C++RLET+F+ F LD D DG+V L +WL
Sbjct: 675 FVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWL 708
>gi|225703100 calpain 2 isoform 2 [Homo sapiens]
Length = 622
Score = 820 bits (2119), Expect = 0.0
Identities = 386/620 (62%), Positives = 491/620 (79%), Gaps = 3/620 (0%)
Query: 80 ELCPSPQFIVGGATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQDFQENYAGIF 139
E+C PQFI+GGATRTDICQG LGDCWLLAAIASLTLNEE+L RVVP +Q FQENYAGIF
Sbjct: 2 EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 61
Query: 140 HFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGS 199
HFQFWQYGEWVEVV+DDRLPTK+G+LLF+HS +G+EFWSALLEKAYAK+NGCYEAL+GG+
Sbjct: 62 HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 121
Query: 200 TVEGFEDFTGGISEFYDLKKPPANLYQIIRKALCAGSLLGCSIDVSSAAEAEAITSQKLV 259
T EGFEDFTGGI+E+Y+LKKPP NL++II+KAL GSLLGCSID++SAA++EAIT QKLV
Sbjct: 122 TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLV 181
Query: 260 KSHAYSVTGVEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDDAPEWNHIDPRRKEELDKKV 319
K HAYSVTG EEV G +KLIR+RNPWGEVEW+G W+D+ P WN IDP +E L ++
Sbjct: 182 KGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRH 241
Query: 320 EDGEFWMSLSDFVRQFSRLEICNLSPDSLSSEEVHKWNLVLFNGHWTRGSTAGGCQNYPA 379
EDGEFWMS SDF+R +SRLEICNL+PD+L+S+ KW L +G+W RGSTAGGC+NYP
Sbjct: 242 EDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPN 301
Query: 380 TYWTNPQFKIRLDEVDEDQEESIGEPCCTVLLGLMQKNRRWRKRIGQGMLSIGYAVYQVP 439
T+W NPQ+ I+L+E DED+E+ GE CT L+GL+QK+RR ++++G+ M +IG+ +Y+VP
Sbjct: 302 TFWMNPQYLIKLEEEDEDEED--GESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVP 359
Query: 440 KELESHTDAHLGRDFFLAYQPSARTSTYVNLREVSGRARLPPGEYLVVPSTFEPFKDGEF 499
+EL T+ HL ++FFL + R+ T++NLREV R +LPPGEY++VPSTFEP KDG+F
Sbjct: 360 EELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDF 419
Query: 500 CLRVFSEKKAQALEIGDVVAGNPYEPHPSEVDQEDDQFRRLFEKLAGKDSEITANALKIL 559
C+RVFSEKKA + D + N E SE D DD FRRLF +LAG+D+EI+A L+ +
Sbjct: 420 CIRVFSEKKADYQAVDDEIEANLEEFDISE-DDIDDGFRRLFAQLAGEDAEISAFELQTI 478
Query: 560 LNEAFSKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEFKTLWLKIQKYLEIYWETDY 619
L +KR DIK DGF+I TC+ M+ +LDS+G+G LG EF LW KIQKY +IY E D
Sbjct: 479 LRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDV 538
Query: 620 NHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGINFDSFVACMIRLETLFKLF 679
+ SGT++++EMR AL +AGF + Q+ Q I R+A +L I+FD+FV C++RLETLFK+F
Sbjct: 539 DRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIF 598
Query: 680 SLLDEDKDGMVQLSLAEWLC 699
LD + G ++L L WLC
Sbjct: 599 KQLDPENTGTIELDLISWLC 618
>gi|215490104 calpain 11 [Homo sapiens]
Length = 739
Score = 739 bits (1909), Expect = 0.0
Identities = 349/694 (50%), Positives = 486/694 (70%), Gaps = 1/694 (0%)
Query: 6 AGVSRQRAATQGLGSNQNALKYLGQDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGP 65
A ++ R +G+G + NA + Q F+ LR CL G LF+DP FPA PS+LG+KDLGP
Sbjct: 40 AHINNSRLKAKGVGQHDNAQNFGNQSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGP 99
Query: 66 GSPQTQGIIWKRPTELCPSPQFIVGGATRTDICQGGLGDCWLLAAIASLTLNEELLYRVV 125
S Q I W+RP ++ +P FI+ G + TDICQG LGDCWLLAAI SLT +LLYRVV
Sbjct: 100 NSKNVQNISWQRPKDIINNPLFIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVV 159
Query: 126 PRDQDFQENYAGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAY 185
PR Q F++NYAGIFHFQ WQ+G+WV VV+DDRLPTKN +L+F+HS + +EFWSALLEKAY
Sbjct: 160 PRGQSFKKNYAGIFHFQIWQFGQWVNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAY 219
Query: 186 AKLNGCYEALAGGSTVEGFEDFTGGISEFYDLKKPPANLYQIIRKALCAGSLLGCSIDVS 245
AKL+G YEAL+GGST+EG EDFTGG+++ + L++PP NL +++RKA+ SL+GCSI+V+
Sbjct: 220 AKLSGSYEALSGGSTMEGLEDFTGGVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIEVT 279
Query: 246 SAAEAEAITSQKLVKSHAYSVTGVEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDDAPEWN 305
S +E E++T + LV+ HAYSVTG+++V+++G E LIR+RNPWG +EW+GAWSD A EW
Sbjct: 280 SDSELESMTDKMLVRGHAYSVTGLQDVHYRGKMETLIRVRNPWGRIEWNGAWSDSAREWE 339
Query: 306 HIDPRRKEELDKKVEDGEFWMSLSDFVRQFSRLEICNLSPDSLSSEEVHKWNLVLFNGHW 365
+ + +L K EDGEFWMS DF+ F+ LEICNL+PD+LS + W+ + G W
Sbjct: 340 EVASDIQMQLLHKTEDGEFWMSYQDFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYEGSW 399
Query: 366 TRGSTAGGCQNYPATYWTNPQFKIRLDEVDEDQEESIGE-PCCTVLLGLMQKNRRWRKRI 424
RGS+AGGC+N+P T+WTNPQFKI L E D+ ++++ G CT L+ LMQKN R ++
Sbjct: 400 RRGSSAGGCRNHPGTFWTNPQFKISLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQ 459
Query: 425 GQGMLSIGYAVYQVPKELESHTDAHLGRDFFLAYQPSARTSTYVNLREVSGRARLPPGEY 484
G + +IG+ +Y VPKE ++ D HL ++FF YQ + + N REVS + RLPPGEY
Sbjct: 460 GAQLQTIGFVLYAVPKEFQNIQDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEY 519
Query: 485 LVVPSTFEPFKDGEFCLRVFSEKKAQALEIGDVVAGNPYEPHPSEVDQEDDQFRRLFEKL 544
+++PSTFEP +D +F LRVF+EK +++ E+ +V + D D F LF+ +
Sbjct: 520 IIIPSTFEPHRDADFLLRVFTEKHSESWELDEVNYAEQLQEEKVSEDDMDQDFLHLFKIV 579
Query: 545 AGKDSEITANALKILLNEAFSKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEFKTLW 604
AG+ EI L+ LLN K K GF ++ CR MI+L+D +G+G LG +EFK LW
Sbjct: 580 AGEGKEIGVYELQRLLNRMAIKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEFKILW 639
Query: 605 LKIQKYLEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGINFDS 664
K++K+++I+ E D +HSGT++++EMR + KAG LN++V Q + RYA L I+FDS
Sbjct: 640 KKLKKWMDIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLIIDFDS 699
Query: 665 FVACMIRLETLFKLFSLLDEDKDGMVQLSLAEWL 698
F++C +RL+T+F F +D G + LSL +WL
Sbjct: 700 FISCFLRLKTMFTFFLTMDPKNTGHICLSLEQWL 733
>gi|27765074 calpain 3 isoform c [Homo sapiens]
Length = 729
Score = 723 bits (1866), Expect = 0.0
Identities = 342/671 (50%), Positives = 479/671 (71%), Gaps = 12/671 (1%)
Query: 32 FKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGSPQTQGIIWKRPTELCPSPQFIVGG 91
F+ L ++CL+ VL+ DPEFP ++L Y P +WKRP E+C +P+FI+ G
Sbjct: 61 FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQ-----FVWKRPPEICENPRFIIDG 115
Query: 92 ATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQDFQENYAGIFHFQFWQYGEWVE 151
A RTDICQG LGDCW LAAIA LTLN+ LL+RV+P DQ F ENYAGIFHFQFW+YGEWV+
Sbjct: 116 ANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVD 175
Query: 152 VVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGSTVEGFEDFTGGI 211
VVIDD LPT N QL+F S NEFWSALLEKAYAKL+G YEAL GG+T E EDFTGG+
Sbjct: 176 VVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGV 235
Query: 212 SEFYDLKKPPANLYQIIRKALCAGSLLGCSIDVSSAAEAEAITSQKLVKSHAYSVTGVEE 271
+EF++++ P+++Y+I++KA+ GSL+GCSID + E + LV+ HAYSVTG++E
Sbjct: 236 AEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDTIIPVQYETRMACGLVRGHAYSVTGLDE 295
Query: 272 VNFQGHPEKLIRLRNPWGEVEWSGAWSDDAPEWNHIDPRRKEELDKKV-EDGEFWMSLSD 330
V F+G KL+RLRNPWG+VEW+G+WSD +W+ +D K L +V EDGEFWMS D
Sbjct: 296 VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 355
Query: 331 FVRQFSRLEICNLSPDSLSSEEVHKWNLVLFNGHWTRGSTAGGCQNYPATYWTNPQFKIR 390
F+ F++LEICNL+ D+L S+++ W + + G W RG +AGGC+N+P T+WTNPQ++++
Sbjct: 356 FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 415
Query: 391 LDEVDEDQEESIGEPCCTVLLGLMQKNRRWRKRIGQGMLSIGYAVYQVPKELESHTDAHL 450
L E D+D ++S E C+ L+ LMQKNRR +++G + +IG+A+Y+VPKE+ + HL
Sbjct: 416 LLEEDDDPDDS--EVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HL 472
Query: 451 GRDFFLAYQPSARTSTYVNLREVSGRARLPPGEYLVVPSTFEPFKDGEFCLRVFSEKKAQ 510
+DFFL AR+ TY+N+REVS R RLPP EY++VPST+EP ++GEF LRVFSEK+
Sbjct: 473 QKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNL 532
Query: 511 ALEIGDVVAGNPYEPHPSEVDQEDD---QFRRLFEKLAGKDSEITANALKILLNEAFSKR 567
+ E+ + ++ + P P DQE + QFR +F+++AG D EI A+ LK +LN +K
Sbjct: 533 SEEVENTISVDRPVPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKH 592
Query: 568 TDIKFDGFNINTCREMISLLDSNGTGTLGAVEFKTLWLKIQKYLEIYWETDYNHSGTIDA 627
D+K GF + +CR MI+L+D++G+G L EF LW KI+ + +I+ D + SGTI++
Sbjct: 593 KDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINS 652
Query: 628 HEMRTALRKAGFTLNSQVQQTIALRYACSKLGINFDSFVACMIRLETLFKLFSLLDEDKD 687
+EMR A+ AGF LN+Q+ I +RYA + I+FDSF+ C +RLE +F+ F D+D D
Sbjct: 653 YEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGD 712
Query: 688 GMVQLSLAEWL 698
G+++L++ EWL
Sbjct: 713 GIIKLNVLEWL 723
>gi|5729758 calpain 9 isoform 1 [Homo sapiens]
Length = 690
Score = 722 bits (1863), Expect = 0.0
Identities = 348/675 (51%), Positives = 476/675 (70%), Gaps = 21/675 (3%)
Query: 29 GQDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGSPQTQGIIWKRPTELCPSPQFI 88
GQ F+ +RQ+CL G LF+D +FPA S+L Y + PQ +WKRP E+ +P+FI
Sbjct: 26 GQSFEQMRQECLQRGTLFEDADFPASNSSLFYSE----RPQIP-FVWKRPGEIVKNPEFI 80
Query: 89 VGGATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQDFQENYAGIFHFQFWQYGE 148
+GGATRTDICQG LGDCWLLAAIASLTLN++ L RV+P+DQ F YAGIFHFQFWQ+ E
Sbjct: 81 LGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSE 140
Query: 149 WVEVVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGSTVEGFEDFT 208
W++VVIDDRLPT +L+FLHS NEFWSALLEKAYAKLNG YEAL GGS +E EDFT
Sbjct: 141 WLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFT 200
Query: 209 GGISEFYDLKKPPANLYQIIRKALCAGSLLGCSIDVSSAAEAEAITSQKLVKSHAYSVTG 268
GG++E + K+ P N Y+I+ KAL GSLLGC ID SAAE+EA T L+K HAYSVTG
Sbjct: 201 GGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTG 260
Query: 269 VEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDDAPEWNHIDPRRKEEL-DKKVEDGEFWMS 327
+++V+F+G +LIR+RNPWG+VEW+G+WSD +PEW + P ++ L ++DGEFWM+
Sbjct: 261 IDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDDGEFWMA 320
Query: 328 LSDFVRQFSRLEICNLSPDSLSSEEVHKWNLVLFNGHWTRGSTAGGCQNYPATYWTNPQF 387
DF F ++EICNL+PD+L + +HKW + + G W RGSTAGGC+N+ T+WTNPQ
Sbjct: 321 FKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQI 380
Query: 388 KIRLDEVDEDQEESIGEPCCTVLLGLMQKNRRWRKRIGQGMLSIGYAVYQVPKELESHTD 447
K+ L E DE QEE C+ L+ LMQK+RR KR G +L+IGYA+Y+ P + D
Sbjct: 381 KLSLTEKDEGQEE------CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDK-----D 429
Query: 448 AHLGRDFFLAYQPSARTSTYVNLREVSGRARLPPGEYLVVPSTFEPFKDGEFCLRVFSEK 507
HL +DFF + AR+ T++NLREVS R +LPPGEY+++PSTFEP ++ +FCLR+FSEK
Sbjct: 430 EHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEK 489
Query: 508 KAQALEI-GDVVAGNPYEPHPSEVDQ---EDDQFRRLFEKLAGKDSEITANALKILLNEA 563
KA ++ G+V P P P+ DQ E+ +FR LFE++AG+D E+TA L+ +LN
Sbjct: 490 KAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAV 549
Query: 564 FSKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEFKTLWLKIQKYLEIYWETDYNHSG 623
K+ DIKF ++ +C+ +ISL+D++G G L EFK W K+++++ ++ D + SG
Sbjct: 550 LQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSG 609
Query: 624 TIDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGINFDSFVACMIRLETLFKLFSLLD 683
T+ +E+RTAL+ AGF L+S + Q I LRYA +L ++FD F+ C++RLE ++F L
Sbjct: 610 TMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALS 669
Query: 684 EDKDGMVQLSLAEWL 698
+ L++ E++
Sbjct: 670 TKNKEFIHLNINEFI 684
>gi|7705383 calpain 9 isoform 2 [Homo sapiens]
Length = 664
Score = 684 bits (1766), Expect = 0.0
Identities = 338/674 (50%), Positives = 460/674 (68%), Gaps = 45/674 (6%)
Query: 29 GQDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGSPQTQGIIWKRPTELCPSPQFI 88
GQ F+ +RQ+CL G LF+D +FPA S+L Y + PQ +WKRP E+ +P+FI
Sbjct: 26 GQSFEQMRQECLQRGTLFEDADFPASNSSLFYSE----RPQIP-FVWKRPGEIVKNPEFI 80
Query: 89 VGGATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQDFQENYAGIFHFQFWQYGE 148
+GGATRTDICQG LGDCWLLAAIASLTLN++ L RV+P+DQ F YAGIFHFQFWQ+ E
Sbjct: 81 LGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSE 140
Query: 149 WVEVVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGSTVEGFEDFT 208
W++VVIDDRLPT +L+FLHS NEFWSALLEKAYAKLNG YEAL GGS +E EDFT
Sbjct: 141 WLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFT 200
Query: 209 GGISEFYDLKKPPANLYQIIRKALCAGSLLGCSIDVSSAAEAEAITSQKLVKSHAYSVTG 268
GG++E + K+ P N Y+I+ KAL GSLLGC ID SAAE+EA T L+K HAYSVTG
Sbjct: 201 GGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTG 260
Query: 269 VEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDDAPEWNHIDPRRKEELDKKVEDGEFWMSL 328
+++V+F+G +LIR+RNPWG+VEW+G+WSD M+
Sbjct: 261 IDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR-------------------------MAF 295
Query: 329 SDFVRQFSRLEICNLSPDSLSSEEVHKWNLVLFNGHWTRGSTAGGCQNYPATYWTNPQFK 388
DF F ++EICNL+PD+L + +HKW + + G W RGSTAGGC+N+ T+WTNPQ K
Sbjct: 296 KDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIK 355
Query: 389 IRLDEVDEDQEESIGEPCCTVLLGLMQKNRRWRKRIGQGMLSIGYAVYQVPKELESHTDA 448
+ L E DE QEE C+ L+ LMQK+RR KR G +L+IGYA+Y+ P + D
Sbjct: 356 LSLTEKDEGQEE------CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDK-----DE 404
Query: 449 HLGRDFFLAYQPSARTSTYVNLREVSGRARLPPGEYLVVPSTFEPFKDGEFCLRVFSEKK 508
HL +DFF + AR+ T++NLREVS R +LPPGEY+++PSTFEP ++ +FCLR+FSEKK
Sbjct: 405 HLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKK 464
Query: 509 AQALEI-GDVVAGNPYEPHPSEVDQ---EDDQFRRLFEKLAGKDSEITANALKILLNEAF 564
A ++ G+V P P P+ DQ E+ +FR LFE++AG+D E+TA L+ +LN
Sbjct: 465 AITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVL 524
Query: 565 SKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEFKTLWLKIQKYLEIYWETDYNHSGT 624
K+ DIKF ++ +C+ +ISL+D++G G L EFK W K+++++ ++ D + SGT
Sbjct: 525 QKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGT 584
Query: 625 IDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGINFDSFVACMIRLETLFKLFSLLDE 684
+ +E+RTAL+ AGF L+S + Q I LRYA +L ++FD F+ C++RLE ++F L
Sbjct: 585 MSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALST 644
Query: 685 DKDGMVQLSLAEWL 698
+ L++ E++
Sbjct: 645 KNKEFIHLNINEFI 658
>gi|27765072 calpain 3 isoform b [Homo sapiens]
Length = 815
Score = 649 bits (1673), Expect = 0.0
Identities = 333/757 (43%), Positives = 463/757 (61%), Gaps = 98/757 (12%)
Query: 32 FKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGSPQTQGIIWKRPTELCPSPQFIVGG 91
F+ L ++CL+ VL+ DPEFP ++L Y P +WKRP E+C +P+FI+ G
Sbjct: 61 FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQ-----FVWKRPPEICENPRFIIDG 115
Query: 92 ATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQDFQENYAGIFHFQFWQYGEWVE 151
A RTDICQG LGDCW LAAIA LTLN+ LL+RV+P DQ F ENYAGIFHFQFW+YGEWV+
Sbjct: 116 ANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVD 175
Query: 152 VVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGSTVEGFEDFTGGI 211
VVIDD LPT N QL+F S NEFWSALLEKAYAKL+G YEAL GG+T E EDFTGG+
Sbjct: 176 VVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGV 235
Query: 212 ----------SEFYDLKKPPANLYQIIRKALCAGSLLGCSIDVSSAAEAEAITSQK---- 257
S+ Y + K ++ ++ G+ + S E I
Sbjct: 236 AEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMD 295
Query: 258 ----------------------------------LVKSHAYSVTGVEEVNFQGHPEKLIR 283
LV+ HAYSVTG++EV F+G KL+R
Sbjct: 296 NSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVR 355
Query: 284 LRNPWGEVEWSGAWSDDAPEWNHIDPRRKEELDKKV-EDGEFWMSLSDFVRQFSRLEICN 342
LRNPWG+VEW+G+WSD +W+ +D K L +V EDGEFWMS DF+ F++LEICN
Sbjct: 356 LRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICN 415
Query: 343 LSPDSLSSEEVHKWNLVLFNGHWTRGSTAGGCQNYPATYWTNPQFKIRLDEVDEDQEESI 402
L+ D+L S+++ W + + G W RG +AGGC+N+P T+WTNPQ++++L E D+D ++S
Sbjct: 416 LTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDS- 474
Query: 403 GEPCCTVLLGLMQKNRRWRKRIGQGMLSIGYAVYQVPKELESHTDAHLGRDFFLAYQPSA 462
E C+ L+ LMQKNRR +++G + +IG+A+Y+VPKE+ + HL +DFFL A
Sbjct: 475 -EVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HLQKDFFLYNASKA 532
Query: 463 RTSTYVNLREVSGRARLPPGEYLVVPSTFEPFKDGEFCLRVFSEKKAQALEIGDVVA--- 519
R+ TY+N+REVS R RLPP EY++VPST+EP ++GEF LRVFSEK+ + E+ + ++
Sbjct: 533 RSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDR 592
Query: 520 -----------------------------------GNPYEPHPSEVDQEDD---QFRRLF 541
+P P DQE + QFR +F
Sbjct: 593 PVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIF 652
Query: 542 EKLAGKDSEITANALKILLNEAFSKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEFK 601
+++AG D EI A+ LK +LN +K D+K GF + +CR MI+L+D++G+G L EF
Sbjct: 653 KQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFH 712
Query: 602 TLWLKIQKYLEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGIN 661
LW KI+ + +I+ D + SGTI+++EMR A+ AGF LN+Q+ I +RYA + I+
Sbjct: 713 HLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNID 772
Query: 662 FDSFVACMIRLETLFKLFSLLDEDKDGMVQLSLAEWL 698
FDSF+ C +RLE +F+ F D+D DG+++L++ EWL
Sbjct: 773 FDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWL 809
>gi|4557405 calpain 3 isoform a [Homo sapiens]
Length = 821
Score = 646 bits (1667), Expect = 0.0
Identities = 333/763 (43%), Positives = 463/763 (60%), Gaps = 104/763 (13%)
Query: 32 FKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGSPQTQGIIWKRPTELCPSPQFIVGG 91
F+ L ++CL+ VL+ DPEFP ++L Y P +WKRP E+C +P+FI+ G
Sbjct: 61 FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQ-----FVWKRPPEICENPRFIIDG 115
Query: 92 ATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQDFQENYAGIFHFQFWQYGEWVE 151
A RTDICQG LGDCW LAAIA LTLN+ LL+RV+P DQ F ENYAGIFHFQFW+YGEWV+
Sbjct: 116 ANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVD 175
Query: 152 VVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGSTVEGFEDFTGGI 211
VVIDD LPT N QL+F S NEFWSALLEKAYAKL+G YEAL GG+T E EDFTGG+
Sbjct: 176 VVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGV 235
Query: 212 ----------SEFYDLKKPPANLYQIIRKALCAGSLLGCSIDVSSAAEAEAITSQK---- 257
S+ Y + K ++ ++ G+ + S E I
Sbjct: 236 AEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMD 295
Query: 258 ----------------------------------LVKSHAYSVTGVEEVNFQGHPEKLIR 283
LV+ HAYSVTG++EV F+G KL+R
Sbjct: 296 NSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVR 355
Query: 284 LRNPWGEVEWSGAWSDDAPEWNHIDPRRKEELDKKV-EDGEFWMSLSDFVRQFSRLEICN 342
LRNPWG+VEW+G+WSD +W+ +D K L +V EDGEFWMS DF+ F++LEICN
Sbjct: 356 LRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICN 415
Query: 343 LSPDSLSSEEVHKWNLVLFNGHWTRGSTAGGCQNYPATYWTNPQFKIRLDEVDEDQEESI 402
L+ D+L S+++ W + + G W RG +AGGC+N+P T+WTNPQ++++L E D+D ++S
Sbjct: 416 LTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDS- 474
Query: 403 GEPCCTVLLGLMQKNRRWRKRIGQGMLSIGYAVYQVPKELESHTDAHLGRDFFLAYQPSA 462
E C+ L+ LMQKNRR +++G + +IG+A+Y+VPKE+ + HL +DFFL A
Sbjct: 475 -EVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HLQKDFFLYNASKA 532
Query: 463 RTSTYVNLREVSGRARLPPGEYLVVPSTFEPFKDGEFCLRVFSEKKAQALEIGDVVA--- 519
R+ TY+N+REVS R RLPP EY++VPST+EP ++GEF LRVFSEK+ + E+ + ++
Sbjct: 533 RSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDR 592
Query: 520 -----------------------------------------GNPYEPHPSEVDQEDD--- 535
+P P DQE +
Sbjct: 593 PVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQ 652
Query: 536 QFRRLFEKLAGKDSEITANALKILLNEAFSKRTDIKFDGFNINTCREMISLLDSNGTGTL 595
QFR +F+++AG D EI A+ LK +LN +K D+K GF + +CR MI+L+D++G+G L
Sbjct: 653 QFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKL 712
Query: 596 GAVEFKTLWLKIQKYLEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYAC 655
EF LW KI+ + +I+ D + SGTI+++EMR A+ AGF LN+Q+ I +RYA
Sbjct: 713 NLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYAD 772
Query: 656 SKLGINFDSFVACMIRLETLFKLFSLLDEDKDGMVQLSLAEWL 698
+ I+FDSF+ C +RLE +F+ F D+D DG+++L++ EWL
Sbjct: 773 KHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWL 815
>gi|47078247 calpain 3 isoform f [Homo sapiens]
Length = 728
Score = 617 bits (1592), Expect = e-177
Identities = 315/713 (44%), Positives = 439/713 (61%), Gaps = 93/713 (13%)
Query: 76 KRPTELCPSPQFIVGGATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQDFQENY 135
++ E+C +P+FI+ GA RTDICQG LGDCW LAAIA LTLN+ LL+RV+P DQ F ENY
Sbjct: 13 QQKNEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENY 72
Query: 136 AGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAYAKLNGCYEAL 195
AGIFHFQFW+YGEWV+VVIDD LPT N QL+F S NEFWSALLEKAYAKL+G YEAL
Sbjct: 73 AGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEAL 132
Query: 196 AGGSTVEGFEDFTGGI----------SEFYDLKKPPANLYQIIRKALCAGSLLGCSIDVS 245
GG+T E EDFTGG+ S+ Y + K ++ ++ G+ + S
Sbjct: 133 KGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPS 192
Query: 246 SAAEAEAITSQK--------------------------------------LVKSHAYSVT 267
E I LV+ HAYSVT
Sbjct: 193 GLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVT 252
Query: 268 GVEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDDAPEWNHIDPRRKEELDKKV-EDGEFWM 326
G++EV F+G KL+RLRNPWG+VEW+G+WSD +W+ +D K L +V EDGEFWM
Sbjct: 253 GLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWM 312
Query: 327 SLSDFVRQFSRLEICNLSPDSLSSEEVHKWNLVLFNGHWTRGSTAGGCQNYPATYWTNPQ 386
S DF+ F++LEICNL+ D+L S+++ W + + G W RG +AGGC+N+P T+WTNPQ
Sbjct: 313 SYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQ 372
Query: 387 FKIRLDEVDEDQEESIGEPCCTVLLGLMQKNRRWRKRIGQGMLSIGYAVYQVPKELESHT 446
++++L E D+D ++S E C+ L+ LMQKNRR +++G + +IG+A+Y+VPKE+ +
Sbjct: 373 YRLKLLEEDDDPDDS--EVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNK 430
Query: 447 DAHLGRDFFLAYQPSARTSTYVNLREVSGRARLPPGEYLVVPSTFEPFKDGEFCLRVFSE 506
HL +DFFL AR+ TY+N+REVS R RLPP EY++VPST+EP ++GEF LRVFSE
Sbjct: 431 Q-HLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSE 489
Query: 507 KKAQALEIGDVVA--------------------------------------GNPYEPHPS 528
K+ + E+ + ++ +P P
Sbjct: 490 KRNLSEEVENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPG 549
Query: 529 EVDQEDD---QFRRLFEKLAGKDSEITANALKILLNEAFSKRTDIKFDGFNINTCREMIS 585
DQE + QFR +F+++AG D EI A+ LK +LN +K D+K GF + +CR MI+
Sbjct: 550 SSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIA 609
Query: 586 LLDSNGTGTLGAVEFKTLWLKIQKYLEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQV 645
L+D++G+G L EF LW KI+ + +I+ D + SGTI+++EMR A+ AGF LN+Q+
Sbjct: 610 LMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQL 669
Query: 646 QQTIALRYACSKLGINFDSFVACMIRLETLFKLFSLLDEDKDGMVQLSLAEWL 698
I +RYA + I+FDSF+ C +RLE +F+ F D+D DG+++L++ EWL
Sbjct: 670 YDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWL 722
>gi|38707981 calpain 12 [Homo sapiens]
Length = 719
Score = 535 bits (1378), Expect = e-152
Identities = 304/728 (41%), Positives = 432/728 (59%), Gaps = 45/728 (6%)
Query: 1 MAAQAAGVSRQRAATQ-GLGSNQNALKYLGQDFKTLRQQCLDSGVLFKDPEFPACPSALG 59
MA+ + V+ Q + G+G+ + L + GQ ++ +R CLDSG+LF+DP FPA P ALG
Sbjct: 1 MASSSGRVTIQLVDEEAGVGAGRLQL-FRGQSYEAIRAACLDSGILFRDPYFPAGPDALG 59
Query: 60 YKDLGPGSPQTQGIIWKRPTELCPSPQFIVGGATRTDICQGGLGDCWLLAAIASLTLNEE 119
Y LGP S + +G+ W RP E C P+FI +RTD+CQG LG+CW LAA ASLTL
Sbjct: 60 YDQLGPDSEKAKGVKWMRPHEFCAEPKFICEDMSRTDVCQGSLGNCWFLAAAASLTLYPR 119
Query: 120 LLYRVVPRDQDFQENYAGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSA 179
LL RVVP QDFQ YAG+FHFQ WQ+G W++VV+DDRLP + G+L+F+ SEQ NEFW+
Sbjct: 120 LLRRVVPPGQDFQHGYAGVFHFQLWQFGRWMDVVVDDRLPVREGKLMFVRSEQRNEFWAP 179
Query: 180 LLEKAYAKLNGCYEALAGGSTVEGFEDFTGGISEFYDLKKPPANLYQIIRKALCAGSLLG 239
LLEKAYAKL+G YE + GG E F DFTGG+ E L++ L+ +R AL SL+G
Sbjct: 180 LLEKAYAKLHGSYEVMRGGHMNEAFVDFTGGVGEVLYLRQNSMGLFSALRHALAKESLVG 239
Query: 240 CSIDVSSAAEAEAITSQKLVKSHAYSVTGVEEVNFQGHPEKLIRLRNPWGEVEWSGAWSD 299
+ + + E T + LVK HAYS+TG +V +L+RLRNPWG VEW+GAWSD
Sbjct: 240 AT---ALSDRGEYRTEEGLVKGHAYSITGTHKVFLGFTKVRLLRLRNPWGCVEWTGAWSD 296
Query: 300 DAPEWNHIDPRRKEELDKKVEDGEFWMSLSDFVRQFSRLEICNLSPDSLS-SEEVHKWNL 358
P W+ + ++ L K EDGEFWM L DF+ F ++IC+LSP+ L S E W++
Sbjct: 297 SCPRWDTLPTECRDALLVKKEDGEFWMELRDFLLHFDTVQICSLSPEVLGPSPEGGGWHV 356
Query: 359 VLFNGHWTRGSTAGGCQNYPATYWTNPQFKIRL----DEVDEDQEESIG----------- 403
F G W RG +GG Q T+WTNPQF++ L +E DED+E G
Sbjct: 357 HTFQGRWVRGFNSGGSQPNAETFWTNPQFRLTLLEPDEEDDEDEEGPWGGWGAAGARGPA 416
Query: 404 ----EPCCTVLLGLMQKNRRWRKRIGQGMLSIGYAVYQVPKELESHTDAHLGRDFFLAYQ 459
P CTVLL L+Q+NRR + G L++G+ V+Q+P+EL D+ L
Sbjct: 417 RGGRTPKCTVLLSLIQRNRRRLRAKGLTYLTVGFHVFQIPEELLGLWDSPRSH-ALLPRL 475
Query: 460 PSARTSTYVNLREVSGRARLPPGEYLVVPSTFEPFKDGEFCLRVFSEKKAQALEIGDVVA 519
A S R+V+ R L PG YLVVPST + +F LRVFSE++ A+EI DV++
Sbjct: 476 LRADRSPLSARRDVTRRCCLRPGHYLVVPSTAHAGDEADFTLRVFSERRHTAVEIDDVIS 535
Query: 520 GN------PYEPHPSEVDQEDDQFRRLFEKLAGKDSEITANALKILLNEAF--SKRTDIK 571
+ PY P ++Q LF++LAG++ E+ A+ L+ LL+ A ++
Sbjct: 536 ADLQSLQGPYLPLELGLEQ-------LFQELAGEEEELNASQLQALLSIALEPARAHTST 588
Query: 572 FDGFNINTCREMISLLDSNGTG-TLGAVEFKTLWLKIQKYLEIYWETDYNHSGTIDAHEM 630
+ TC + LL G G +L F+ LW + ++ I+ + D + SGT++++E+
Sbjct: 589 PREIGLRTCEQ---LLQCFGHGQSLALHHFQQLWGYLLEWQAIFNKFDEDTSGTMNSYEL 645
Query: 631 RTALRKAGFTLNSQVQQTIALRYACSKLGINFDSFVACMIRLETLFKLFSLLDEDKDGMV 690
R AL AGF LN+Q+ QT+ RY S+L ++F+ FV+C+ L +F S + +G++
Sbjct: 646 RLALNAAGFHLNNQLTQTLTSRYRDSRLRVDFERFVSCVAHLTCIFCHCSQHLDGGEGVI 705
Query: 691 QLSLAEWL 698
L+ +W+
Sbjct: 706 CLTHRQWM 713
>gi|223468608 calpain 14 [Homo sapiens]
Length = 684
Score = 457 bits (1176), Expect = e-128
Identities = 266/677 (39%), Positives = 382/677 (56%), Gaps = 26/677 (3%)
Query: 30 QDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGSPQTQGIIWKRPTELCPSPQFIV 89
QDF+ L +CL +G LF+D FPA S++G L P + WKRP EL +PQF
Sbjct: 28 QDFEALLAECLRNGCLFEDTSFPATLSSIGSGSLLQKLPPR--LQWKRPPELHSNPQFYF 85
Query: 90 GGATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQDFQENYAGIFHFQFWQYGEW 149
A R D+CQG +GDCW LAA+ +L L++++L RVVP +Q F E YAGIF F FW YG W
Sbjct: 86 AKAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNW 145
Query: 150 VEVVIDDRLPTKN-GQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGSTVEGFEDFT 208
V VVIDDRLP GQL+F+ S N FW ALLEKAYAKL+G YE L G E DFT
Sbjct: 146 VPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFT 205
Query: 209 GGISEFYDLKKPPANLYQIIRKALCAGSLLGCSIDVSSAAEAEAITSQKLVKSHAYSVTG 268
GG++ +L + NL+ I+ +A +L+GC E I LV+ HAY++TG
Sbjct: 206 GGVTMTINLAEAHGNLWDILIEATYNRTLIGCQTH-----SGEKILENGLVEGHAYTLTG 260
Query: 269 VEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDDAPEWNHIDPRRKEELDKKVEDGEFWMSL 328
+ +V + PE L++LRNPWG+VEW G WSD + +W + P+ K L +K DGEFWM+L
Sbjct: 261 IRKVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRKDNDGEFWMTL 320
Query: 329 SDFVRQFSRLEICNLSPDSLSSEEVHKWNLVLFNGHWTRGSTAGG-CQNYPATYWTNPQF 387
DF F L IC L+P LS E KW + G W + STAGG Q T+W NPQF
Sbjct: 321 QDFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQF 380
Query: 388 KIRLDEVDEDQEESIGEPCCTVLLGLMQKNR-RWRKRIGQGMLSIGYAVYQVPKELESHT 446
+ + +E + P C+VL+ L+QK R R RKR + +L+IG+ +Y++ K H
Sbjct: 381 LLSVWRPEEGRRSL--RP-CSVLVSLLQKPRHRCRKR--KPLLAIGFYLYRMNK---YHD 432
Query: 447 D-AHLGRDFFLAYQPSARTSTYVNLREVSGRARLPPGEYLVVPSTFEPFKDGEFCLRVFS 505
D L +FF P ++ ++ +EVS L PG YL+VP E + EF LRVFS
Sbjct: 433 DQRRLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEFVLRVFS 492
Query: 506 EKKAQALEIGDVVAGNPYEPHPSEVDQEDDQFRRLFEKLAGKDSEITANALKILLNEAFS 565
K I + N E++ ++++ F K K EI A L+ LLN+
Sbjct: 493 RK-----HIFYEIGSNSGVVFSKEIEDQNERQDEFFTKFFEKHPEINAVQLQNLLNQMTW 547
Query: 566 KRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEFKTLWLKIQKYLEIYWETDYNHSGTI 625
+ F++ C+ +++LLD N +GT+ EF+ LW +++ +++ + D SG +
Sbjct: 548 SSLGSRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQD-RGSGYL 606
Query: 626 DAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGINFDSFVACMIRLETLFKLFSLLDED 685
+ ++ A+R+AG L+ V Q + +RY +L ++F SF+ M+R+E + +F L +D
Sbjct: 607 NWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVFQNLTQD 666
Query: 686 KDGMVQLSLAEWLCCVL 702
G + L EW+ L
Sbjct: 667 GKG-IYLQKPEWMMMAL 682
>gi|37577157 calpain 5 [Homo sapiens]
Length = 640
Score = 349 bits (895), Expect = 6e-96
Identities = 205/518 (39%), Positives = 294/518 (56%), Gaps = 57/518 (11%)
Query: 27 YLGQDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGSPQTQGIIWKRPTELCPSPQ 86
Y Q++ LR+ C VLF+DP FPA +L YK G+P + WKRP +C P+
Sbjct: 8 YEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYK----GTPGP-AVRWKRPKGICEDPR 62
Query: 87 FIVGGATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVP--RDQDFQEN----YAGIFH 140
V G + D+ QG +G+CW +AA +SL E L +V+P ++Q++ YAGIFH
Sbjct: 63 LFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFH 122
Query: 141 FQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGST 200
F FW++GEWV+VVIDDRLPT N QL++ HS NEFW AL+EKAYAKL GCY+AL GG+T
Sbjct: 123 FHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNT 182
Query: 201 VEGFEDFTGGISEFYDLKKPP-AN-------LYQIIRKALCAGSLLGCSIDVSSAAEAEA 252
+ DFTGG+SE DL + AN L++ + K G L+ SI +AA+ EA
Sbjct: 183 ADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADMEA 242
Query: 253 ITSQKLVKSHAYSVTGVEEVN--------FQGHPEKLIRLRNPWGEVEWSGAWSDDAPEW 304
+ LVK HAY+VT V +V F+ +IRLRNPWGE EW+G WSD + EW
Sbjct: 243 RLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEW 302
Query: 305 NHIDPRRKEELDKKV-EDGEFWMSLSDFVRQFSRLEICNLSPDSLSSEEVHK-WNLVLFN 362
+ +E++ V +DGEFWM+ D R F+ + C + + S +HK W +
Sbjct: 303 QKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVI--NTSHLSIHKTWEEARLH 360
Query: 363 GHWT-----RGSTAGGCQNYPATYWTNPQFKIRLDEVDEDQEESIGEPCCTVLLGLMQKN 417
G WT R + GGC N+ T++ NPQ+ + EV + ++E VL+ + Q+
Sbjct: 361 GAWTLHEDPRQNRGGGCINHKDTFFQNPQY---IFEVKKPEDE--------VLICIQQRP 409
Query: 418 RRWRKRIGQG-MLSIGYAVYQVPKELESHTDAHLGRDFFLAYQPSARTSTYVNLREVSGR 476
+R +R G+G L+IG+ +Y+V + + + Q A +S Y+N R V R
Sbjct: 410 KRSTRREGKGENLAIGFDIYKVEENRQYRMH---------SLQHKAASSIYINSRSVFLR 460
Query: 477 ARLPPGEYLVVPSTFEPFKDGEFCLRVFSEKKAQALEI 514
P G Y+++P+TFEP GEF LRVF++ + E+
Sbjct: 461 TDQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCREL 498
>gi|41152101 calpain 13 [Homo sapiens]
Length = 669
Score = 331 bits (848), Expect = 2e-90
Identities = 232/695 (33%), Positives = 346/695 (49%), Gaps = 58/695 (8%)
Query: 25 LKYLGQDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGSPQTQGIIWKRPTELCPS 84
+K+ QDF TLR CL G FKD FPA S++G K L + +IWKRP +L
Sbjct: 14 IKFKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQ--EKRLSNVIWKRPQDLPGG 71
Query: 85 P-QFIVGGATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQDFQENYAGIFHFQF 143
P FI+ +R DI QGG DCW LAA+ SLT N + +++ Q F YAGIF F+F
Sbjct: 72 PPHFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKIL-MVQSFSHQYAGIFRFRF 130
Query: 144 WQYGEWVEVVIDDRLPTKNGQLLFLHSE-QGNEFWSALLEKAYAKLNGCYEALAGGSTVE 202
WQ G+WVEVVIDDRLP + + LF+ Q EFW LLEKAYAKL G Y L G +
Sbjct: 131 WQCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLED 190
Query: 203 GFEDFTGGISEFYDLKKPPANLYQIIRKALCAGSLLGCSIDVSSAAEAEAITSQKLVKSH 262
D TGG+ L P +L + ++ A AGSL+ C+ A+A+ + LV H
Sbjct: 191 ALVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQAMENG-LVSLH 249
Query: 263 AYSVTGVEEVNFQGHPEKLIRLRNPWG--EVEWSGAWSDDAPEWNHIDPRRKEELDKKVE 320
AY+VTG E++ ++ E++I L NPWG E EW G WSD + EW RK +L KK E
Sbjct: 250 AYTVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQLHKKRE 309
Query: 321 DGEFWMSLSDFVRQFSRLEICNLSPDSLS-SEEVHK-WNLVLFNGHWTRGSTAGGCQNYP 378
DGEFWMS DF ++F + IC+ P +L +H+ W+ ++F G+TAGG +N
Sbjct: 310 DGEFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRN-- 367
Query: 379 ATYWTNPQFKIRLDEVDEDQEESIGEPCCTVLL---GLMQKNRRWRKRIGQGMLSIGYAV 435
+ QF V E E + C TV + L ++ ++
Sbjct: 368 -----DAQFNF---SVQEPMEGTNVVVCVTVAVTPSNLKAEDAKFP------------LD 407
Query: 436 YQVPKELESHTDAHLGRDFFLAYQPSARTSTYVNLREVSGRARLPPGEYLVVPSTFEPFK 495
+QV FF +++ + ++S R + L PG Y+VV T K
Sbjct: 408 FQVILAGSQRFREKFPPVFFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQTRR--K 465
Query: 496 DGEFCLRVFSEKKAQALEIGD----VVAGNPYEPHPSEVDQEDDQFRRLFEKLAGKDSEI 551
EF LR+F + + + G+P E H S+ + +F + A + +I
Sbjct: 466 SAEFLLRIFLKMPDSDRHLSSHFNLRMKGSPSE-HGSQ--------QSIFNRYAQQRLDI 516
Query: 552 TANALKILLNEAFSKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEFKTLWLKIQKYL 611
A L+ LLN+ T D F+++ CR +++L++ G L EF LW ++ Y
Sbjct: 517 DATQLQGLLNQEL--LTGPPGDMFSLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQ 574
Query: 612 EIYWETDYNHSGTIDAHEMRTALRKA----GFTLNSQVQQTIALRYACSKLGINFDSFVA 667
++ + G + + ++ A+ G ++ ++ + LRY+ S ++F S V
Sbjct: 575 HVFQKVQ-TSPGVLLSSDLWKAIENTDFLRGIFISRELLHLVTLRYSDSVGRVSFPSLVC 633
Query: 668 CMIRLETLFKLFSLLDEDKDGMVQLSLAEWLCCVL 702
++RLE + K F L +D G+ L+ EW+ V+
Sbjct: 634 FLMRLEAMAKTFRNLSKDGKGL-YLTEMEWMSLVM 667
>gi|13186316 calpain 6 [Homo sapiens]
Length = 641
Score = 290 bits (743), Expect = 2e-78
Identities = 185/518 (35%), Positives = 270/518 (52%), Gaps = 58/518 (11%)
Query: 27 YLGQDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGSPQTQGIIWKRPTELCPSPQ 86
+ Q ++ L+Q+C+ LF DP F +L Y L PG ++WKRP ++C P
Sbjct: 8 FKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGK-----VVWKRPQDICDDPH 62
Query: 87 FIVGGATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQDFQ------ENYAGIFH 140
IVG + + QG LG +++A + L + E + +P ++ + E YAGIFH
Sbjct: 63 LIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFH 122
Query: 141 FQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGST 200
F+FW +GEW EVVIDD LPT NG L+F S NEFW+ALLEKAYAKL GCYEAL G +
Sbjct: 123 FRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTI 182
Query: 201 VEGFEDFTGGISEFYDLKK--------PPANLYQIIRKALCAGSLLGCSIDVSSAAEAEA 252
+ DFTG ++E D++K L+ + K G L+ CSI+ + E E
Sbjct: 183 TDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEV 242
Query: 253 ITSQKLVKSHAYSVTGVEEVN--------FQGHPEKLIRLRNPWGEVEWSGAWSDDAPEW 304
T L+K H Y++T + ++ F ++RLRNP G EWSG WS+ + EW
Sbjct: 243 ETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEW 302
Query: 305 NHIDPRRKEELDKKV-EDGEFWMSLSDFVRQFSRLEIC-NLSPDSLSSEEVHKWNLVLFN 362
+ ++ L + +DGEFWMSL DF R F +L +C N++ +E+ VL
Sbjct: 303 QQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELES---VL-- 357
Query: 363 GHWTRG-----STAGGCQNYPATYWTNPQFKIRLDEVDEDQEESIGEPCCTVLLGLMQKN 417
G WT + +GGC N T+ NPQ+ + V ED + V++ L QK+
Sbjct: 358 GCWTVDDDPLMNRSGGCYNNRDTFLQNPQY---IFTVPEDGHK--------VIMSLQQKD 406
Query: 418 RRWRKRIGQ-GMLSIGYAVYQVPKELESHTDAHLGRDFFLAYQPSARTSTYVNLREVSGR 476
R +R+G+ IG+ +++V E+ H L Q A TSTY++ R V
Sbjct: 407 LRTYRRMGRPDNYIIGFELFKV--EMNRKFRLH-----HLYIQERAGTSTYIDTRTVFLS 459
Query: 477 ARLPPGEYLVVPSTFEPFKDGEFCLRVFSEKKAQALEI 514
L G Y++VP+ F+ + EF LR+FSE Q E+
Sbjct: 460 KYLKKGNYVLVPTMFQHGRTSEFLLRIFSEVPVQLREL 497
>gi|13186302 calpain 10 isoform a [Homo sapiens]
Length = 672
Score = 230 bits (587), Expect = 3e-60
Identities = 158/494 (31%), Positives = 242/494 (48%), Gaps = 52/494 (10%)
Query: 45 LFKDPEFPACPSALGYKDLGPGSPQTQGIIWKRPTELCPSPQFIVGGATRTDICQGGLGD 104
LF+D FPA S+L P + + I W+RP E+C +P+ + QG LGD
Sbjct: 13 LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72
Query: 105 CWLLAAIASLTLNEELLYRVVPRDQDF--QENYAGIFHFQFWQYGEWVEVVIDDRLPTKN 162
CW L A A+L + LL +V+P Q + Y G F + WQ+G WVEV DDRLP
Sbjct: 73 CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLA 132
Query: 163 GQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGSTVEGFEDFTGGISEFYDLK---- 218
G+L F ++ + FW LLEK YAK++G YE L G + D TGG++E ++LK
Sbjct: 133 GRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAG 192
Query: 219 ------KPPANLYQIIRKALCAGS--LLGCSIDVSSAAEAEAITSQKLVKSHAYSVTGVE 270
+P ++ R+ L L+ C + +S A A ++L + HA+ V+ +
Sbjct: 193 SGGQQDRPGRWEHRTCRQLLHLKDQCLISCCV-LSPRAGA-----RELGEFHAFIVSDLR 246
Query: 271 EVNFQ-GHPEKLIRLRNPWGEVEWSGAWSDDAPEWNHIDPRRKEELDKKVEDGEFWMSLS 329
E+ Q G L+R++NPWG W G W + W+ +D EL ++++GEFW+
Sbjct: 247 ELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVEEE 306
Query: 330 DFVRQFSRLEICNLSPDSLSSEEVHKWNLVLFN----GHWTRGSTAGGCQNYPATYWTNP 385
+F+R+F L + ++ + ++ L+ G W +G +AGGC+N + + +NP
Sbjct: 307 EFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRN-NSGFPSNP 365
Query: 386 QFKIRLDEVDEDQEESIGEPCCTVLLGLMQKNR----RW--RKRIGQGMLSIGYAVYQVP 439
+F +R+ E E V + ++Q++R W R R G ++ +P
Sbjct: 366 KFWLRVSEPSE------------VYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIP 413
Query: 440 KELESHTDAHLGR--------DFFLAYQPSARTSTYVNLREVSGRARLPPGEYLVVPSTF 491
+ HL + L+ P A T+ + REV R L PG YL VPSTF
Sbjct: 414 GKHYQAVGLHLWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYYLAVPSTF 473
Query: 492 EPFKDGEFCLRVFS 505
GEF LRVFS
Sbjct: 474 LKDAPGEFLLRVFS 487
Score = 53.9 bits (128), Expect = 5e-07
Identities = 44/149 (29%), Positives = 63/149 (42%), Gaps = 19/149 (12%)
Query: 355 KWNLVLFNGHWTRGSTAGGCQNYPATYWTNPQFKIRLDEVDEDQEESIGEPCCTVLLGLM 414
+W V G W G TAGG +N+ A+Y TNP F + E G C + L
Sbjct: 513 EWGTVQLRGSWRVGQTAGGSRNF-ASYPTNPCFPFSVPE-------GPGPRCVRITL--- 561
Query: 415 QKNRRWRKRIGQGMLSIGYAVYQVPKELESHTDAHLGRDFFLAYQPSARTSTYVNLREVS 474
+ + IG+ ++QVP+ S L L +P + +EVS
Sbjct: 562 ---HQHCRPSDTEFHPIGFHIFQVPEGGRSQDAPPL-----LLQEPLLSCVPHRYAQEVS 613
Query: 475 GRARLPPGEYLVVPSTFEPFKDGEFCLRV 503
LP G Y VVPST+ P +G F + +
Sbjct: 614 RLCLLPAGTYKVVPSTYLPDTEGAFTVTI 642
>gi|27765076 calpain 3 isoform d [Homo sapiens]
Length = 309
Score = 223 bits (567), Expect = 6e-58
Identities = 117/297 (39%), Positives = 174/297 (58%), Gaps = 47/297 (15%)
Query: 449 HLGRDFFLAYQPSARTSTYVNLREVSGRARLPPGEYLVVPSTFEPFKDGEFCLRVFSEKK 508
HL +DFFL AR+ TY+N+REVS R RLPP EY++VPST+EP ++GEF LRVFSEK+
Sbjct: 7 HLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKR 66
Query: 509 AQALEIGDVVAGN--------------------------------------------PYE 524
+ E+ + ++ + +
Sbjct: 67 NLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQ 126
Query: 525 PHPSEVDQEDD---QFRRLFEKLAGKDSEITANALKILLNEAFSKRTDIKFDGFNINTCR 581
P P DQE + QFR +F+++AG D EI A+ LK +LN +K D+K GF + +CR
Sbjct: 127 PQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCR 186
Query: 582 EMISLLDSNGTGTLGAVEFKTLWLKIQKYLEIYWETDYNHSGTIDAHEMRTALRKAGFTL 641
MI+L+D++G+G L EF LW KI+ + +I+ D + SGTI+++EMR A+ AGF L
Sbjct: 187 SMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHL 246
Query: 642 NSQVQQTIALRYACSKLGINFDSFVACMIRLETLFKLFSLLDEDKDGMVQLSLAEWL 698
N+Q+ I +RYA + I+FDSF+ C +RLE +F+ F D+D DG+++L++ EWL
Sbjct: 247 NNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWL 303
>gi|89353291 calpain 10 isoform c [Homo sapiens]
Length = 517
Score = 218 bits (554), Expect = 2e-56
Identities = 151/499 (30%), Positives = 240/499 (48%), Gaps = 64/499 (12%)
Query: 45 LFKDPEFPACPSALGYKDLGPGSPQTQGIIWKRPTELCPSPQFIVGGATRTDICQGGLGD 104
LF+D FPA S+L P + + I W+RP E+C +P+ + QG LGD
Sbjct: 13 LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72
Query: 105 CWLLAAIASLTLNEELLYRVVPRDQDF--QENYAGIFHFQFWQYGEWVEVVIDDRLPTKN 162
CW L A A+L + LL +V+P Q + Y G F + WQ+G WVEV DDRLP
Sbjct: 73 CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLA 132
Query: 163 GQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGSTVEGFEDFTGGISEFYDLK---- 218
G+L F ++ + FW LLEK YAK++G YE L G + D TGG++E ++LK
Sbjct: 133 GRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAG 192
Query: 219 ------KPPANLYQIIRKALCAGS--LLGCSIDVSSAAEAEAITSQKLVKSHAYSVTGVE 270
+P ++ R+ L L+ C + +S A A ++L + HA+ V+ +
Sbjct: 193 SGGQQDRPGRWEHRTCRQLLHLKDQCLISCCV-LSPRAGA-----RELGEFHAFIVSDLR 246
Query: 271 EVNFQ-GHPEKLIRLRNPWGEVEWSGAWSDDAPEWNHIDPRRKEELDKKVEDGEFWMSLS 329
E+ Q G L+R++NPWG W G W + W+ +D EL ++++GEFW+
Sbjct: 247 ELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVEEE 306
Query: 330 DFVRQFSRLEICNLSPDSLSSEEVHKWNLVLFN----GHWTRGSTAGGCQNYPATYWTNP 385
+F+R+F L + ++ + ++ L+ G W +G +AGGC+N + + +NP
Sbjct: 307 EFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRN-NSGFPSNP 365
Query: 386 QFKIRLDEVDEDQEESIGEPCCTVLLGLMQKNR--------RWRKRIGQGMLS------- 430
+F +R+ E E V + ++Q++R R R +G S
Sbjct: 366 KFWLRVSEPSE------------VYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIP 413
Query: 431 ------IGYAVYQVPKELESHTDAHLGRDFFLAYQPSARTSTYVNLREVSGRARLPPGEY 484
+G +++VP+ S L L +P + +EVS LP G Y
Sbjct: 414 GKHYQAVGLHLWKVPEGGRSQDAPPL-----LLQEPLLSCVPHRYAQEVSRLCLLPAGTY 468
Query: 485 LVVPSTFEPFKDGEFCLRV 503
VVPST+ P +G F + +
Sbjct: 469 KVVPSTYLPDTEGAFTVTI 487
>gi|14161692 calpain small subunit 2 [Homo sapiens]
Length = 248
Score = 159 bits (402), Expect = 8e-39
Identities = 75/181 (41%), Positives = 122/181 (67%), Gaps = 4/181 (2%)
Query: 522 PYEPHPSEVDQEDDQ----FRRLFEKLAGKDSEITANALKILLNEAFSKRTDIKFDGFNI 577
P + H + V+ + + FR+ F +LAG D E+ A L +LN+ SK D+K DGF++
Sbjct: 62 PTQQHFTSVEASESEEVRRFRQQFTQLAGPDMEVGATDLMNILNKVLSKHKDLKTDGFSL 121
Query: 578 NTCREMISLLDSNGTGTLGAVEFKTLWLKIQKYLEIYWETDYNHSGTIDAHEMRTALRKA 637
+TCR ++S++DS+ TG LG EFK LW I+K+ +Y + D +HSG++ + ++R AL+ A
Sbjct: 122 DTCRSIVSVMDSDTTGKLGFEEFKYLWNNIKKWQCVYKQYDRDHSGSLGSSQLRGALQAA 181
Query: 638 GFTLNSQVQQTIALRYACSKLGINFDSFVACMIRLETLFKLFSLLDEDKDGMVQLSLAEW 697
GF LN Q+ Q I RYA ++F++F++C++RL+ +F+ F LD D+DG++Q+S+ EW
Sbjct: 182 GFQLNEQLYQMIVRRYANEDGDMDFNNFISCLVRLDAMFRAFKSLDRDRDGLIQVSIKEW 241
Query: 698 L 698
L
Sbjct: 242 L 242
>gi|5032105 small optic lobes [Homo sapiens]
Length = 1086
Score = 155 bits (392), Expect = 1e-37
Identities = 111/327 (33%), Positives = 154/327 (47%), Gaps = 31/327 (9%)
Query: 39 CLDSGVLFKDPEFPACPSALGYKDLGPGSPQTQGIIWKRPTELCPS-------PQFIVGG 91
C ++ V F D FP P ++G+ S Q + W RP E+ S +
Sbjct: 481 CRENNVSFVDDSFPPGPESVGFP--AGDSVQQRVRQWLRPQEINCSVFRDHRATWSVFHT 538
Query: 92 ATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQDFQENYAGIFHFQFWQYGEWVE 151
+DI QG LG+CW L+A+A L +L+ RV+ E G + + + G W
Sbjct: 539 LRPSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAE---GAYQVRLCKDGTWTT 595
Query: 152 VVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGSTVEGFEDFTGGI 211
V++DD LP L Q + W AL+EKA AKL+G Y AL G +EG TG
Sbjct: 596 VLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAP 655
Query: 212 SEFYDL-------KKPPANLYQIIRKALC---AGSLLGCSIDVSS-AAEAEAITSQKLVK 260
E L ++ P + I K L AG L+G S + + A S L
Sbjct: 656 CESLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYESLGLRP 715
Query: 261 SHAYSVTGVEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDDAPEW-NHIDPRRKEELDKKV 319
HAYS+ V +V QG +L+RLRNPWG W+G+WSD+ P W H+ R E +
Sbjct: 716 RHAYSILDVRDV--QG--TRLLRLRNPWGRFSWNGSWSDEWPHWPGHL---RGELMPHGS 768
Query: 320 EDGEFWMSLSDFVRQFSRLEICNLSPD 346
+G FWM DFVR F ++IC + D
Sbjct: 769 SEGVFWMEYGDFVRYFDSVDICKVHSD 795
>gi|4502565 calpain, small subunit 1 [Homo sapiens]
Length = 268
Score = 150 bits (380), Expect = 3e-36
Identities = 74/181 (40%), Positives = 115/181 (63%), Gaps = 4/181 (2%)
Query: 522 PYEPHPSEVD----QEDDQFRRLFEKLAGKDSEITANALKILLNEAFSKRTDIKFDGFNI 577
P H S ++ +E QFRRLF +LAG D E++A L +LN+ ++ D+K DGF I
Sbjct: 82 PPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGI 141
Query: 578 NTCREMISLLDSNGTGTLGAVEFKTLWLKIQKYLEIYWETDYNHSGTIDAHEMRTALRKA 637
+TCR M++++DS+ TG LG EFK LW I+++ IY + D + SGTI + E+ A A
Sbjct: 142 DTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAA 201
Query: 638 GFTLNSQVQQTIALRYACSKLGINFDSFVACMIRLETLFKLFSLLDEDKDGMVQLSLAEW 697
GF LN + I RY+ ++FD+F++C++RL+ +F+ F LD+D G +Q+++ EW
Sbjct: 202 GFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEW 261
Query: 698 L 698
L
Sbjct: 262 L 262
>gi|51599151 calpain, small subunit 1 [Homo sapiens]
Length = 268
Score = 150 bits (380), Expect = 3e-36
Identities = 74/181 (40%), Positives = 115/181 (63%), Gaps = 4/181 (2%)
Query: 522 PYEPHPSEVD----QEDDQFRRLFEKLAGKDSEITANALKILLNEAFSKRTDIKFDGFNI 577
P H S ++ +E QFRRLF +LAG D E++A L +LN+ ++ D+K DGF I
Sbjct: 82 PPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGI 141
Query: 578 NTCREMISLLDSNGTGTLGAVEFKTLWLKIQKYLEIYWETDYNHSGTIDAHEMRTALRKA 637
+TCR M++++DS+ TG LG EFK LW I+++ IY + D + SGTI + E+ A A
Sbjct: 142 DTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAA 201
Query: 638 GFTLNSQVQQTIALRYACSKLGINFDSFVACMIRLETLFKLFSLLDEDKDGMVQLSLAEW 697
GF LN + I RY+ ++FD+F++C++RL+ +F+ F LD+D G +Q+++ EW
Sbjct: 202 GFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEW 261
Query: 698 L 698
L
Sbjct: 262 L 262
>gi|27765080 calpain 3 isoform e [Homo sapiens]
Length = 156
Score = 141 bits (356), Expect = 2e-33
Identities = 66/149 (44%), Positives = 101/149 (67%)
Query: 550 EITANALKILLNEAFSKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEFKTLWLKIQK 609
EI A+ LK +LN +K D+K GF + +CR MI+L+D++G+G L EF LW KI+
Sbjct: 2 EICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKA 61
Query: 610 YLEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGINFDSFVACM 669
+ +I+ D + SGTI+++EMR A+ AGF LN+Q+ I +RYA + I+FDSF+ C
Sbjct: 62 WQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCF 121
Query: 670 IRLETLFKLFSLLDEDKDGMVQLSLAEWL 698
+RLE +F+ F D+D DG+++L++ EWL
Sbjct: 122 VRLEGMFRAFHAFDKDGDGIIKLNVLEWL 150
>gi|27765078 calpain 3 isoform e [Homo sapiens]
Length = 156
Score = 141 bits (356), Expect = 2e-33
Identities = 66/149 (44%), Positives = 101/149 (67%)
Query: 550 EITANALKILLNEAFSKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEFKTLWLKIQK 609
EI A+ LK +LN +K D+K GF + +CR MI+L+D++G+G L EF LW KI+
Sbjct: 2 EICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKA 61
Query: 610 YLEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGINFDSFVACM 669
+ +I+ D + SGTI+++EMR A+ AGF LN+Q+ I +RYA + I+FDSF+ C
Sbjct: 62 WQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCF 121
Query: 670 IRLETLFKLFSLLDEDKDGMVQLSLAEWL 698
+RLE +F+ F D+D DG+++L++ EWL
Sbjct: 122 VRLEGMFRAFHAFDKDGDGIIKLNVLEWL 150
>gi|38679884 sorcin isoform b [Homo sapiens]
Length = 183
Score = 98.6 bits (244), Expect = 2e-20
Identities = 57/176 (32%), Positives = 94/176 (53%), Gaps = 4/176 (2%)
Query: 527 PSEVDQEDDQFRRLFEKLAGKDSEITANALKILLNEAFSKRTDIKFDGFNINTCREMISL 586
P+ Q D F +AG+D +I A+ L+ L ++ + FN+ TCR M+S+
Sbjct: 10 PAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGG---YKPFNLETCRLMVSM 66
Query: 587 LDSNGTGTLGAVEFKTLWLKIQKYLEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQ 646
LD + +GT+G EFK LW + + + + D + SGT+D E++ AL GF L+ Q
Sbjct: 67 LDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAV 126
Query: 647 QTIALRYACSKLGINFDSFVACMIRLETLFKLFSLLDEDKDGMVQLSLAEWLCCVL 702
+IA RY+ + I FD ++AC ++L L F D + G+V +++ CV+
Sbjct: 127 NSIAKRYSTNG-KITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVM 181
>gi|4507207 sorcin isoform a [Homo sapiens]
Length = 198
Score = 98.6 bits (244), Expect = 2e-20
Identities = 57/176 (32%), Positives = 94/176 (53%), Gaps = 4/176 (2%)
Query: 527 PSEVDQEDDQFRRLFEKLAGKDSEITANALKILLNEAFSKRTDIKFDGFNINTCREMISL 586
P+ Q D F +AG+D +I A+ L+ L ++ + FN+ TCR M+S+
Sbjct: 25 PAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGG---YKPFNLETCRLMVSM 81
Query: 587 LDSNGTGTLGAVEFKTLWLKIQKYLEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQ 646
LD + +GT+G EFK LW + + + + D + SGT+D E++ AL GF L+ Q
Sbjct: 82 LDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAV 141
Query: 647 QTIALRYACSKLGINFDSFVACMIRLETLFKLFSLLDEDKDGMVQLSLAEWLCCVL 702
+IA RY+ + I FD ++AC ++L L F D + G+V +++ CV+
Sbjct: 142 NSIAKRYSTNG-KITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVM 196
>gi|7656959 calpain 7 [Homo sapiens]
Length = 813
Score = 92.4 bits (228), Expect = 1e-18
Identities = 79/284 (27%), Positives = 137/284 (48%), Gaps = 36/284 (12%)
Query: 75 WKRPTELCPSPQFIVGGATRTDICQGGLGDCWLLAAIA-----SLTLNEELLYRVV-PRD 128
W RP +L +P I + I Q + DC +A++A N++L+ ++ P++
Sbjct: 261 WVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQN 319
Query: 129 QDFQENY--AGIFHFQFWQYGEWVEVVIDDRLPTKN-GQLLFLHSEQGNEFWSALLEKAY 185
+D + Y G + + G +V+IDD+LP + G+LL +S +E W +L+EKAY
Sbjct: 320 KDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKAY 379
Query: 186 AKLNGCYEALAGGSTVEGFEDFTGGISEFYDLKKPPA-----NLYQIIRKALCAGS-LLG 239
K+ G Y+ S ++ TG I E + N ++++ + G L+
Sbjct: 380 MKVMGGYDFPGSNSNID-LHALTGWIPERIAMHSDSQTFSKDNSFRMLYQRFHKGDVLIT 438
Query: 240 CSIDVSSAAEAEAITSQKLVKSHAYSVTGVEEVNFQGHPEKLIRLRNPWGEVEWSGAWSD 299
S + + AE E LV +HAY+V + E F+G + I+L+NPW + W G +S+
Sbjct: 439 ASTGMMTEAEGE---KWGLVPTHAYAVLDIRE--FKG--LRFIQLKNPWSHLRWKGRYSE 491
Query: 300 -DAPEWN-------HIDPRRKEELDKKVEDGEFWMSLSDFVRQF 335
D W + DPR + K+++G FW+S D + +
Sbjct: 492 NDVKNWTPELQKYLNFDPRTAQ----KIDNGIFWISWDDLCQYY 531
Score = 33.9 bits (76), Expect = 0.53
Identities = 35/140 (25%), Positives = 53/140 (37%), Gaps = 33/140 (23%)
Query: 362 NGHWTRGSTAGGCQNYPATYWTNPQFKIRLDEVDEDQEESIGEPCCTVLLGLMQKNRRWR 421
NG W+ G +AGGC N+ T+ NP ++ +++ P L G Q
Sbjct: 693 NGKWS-GQSAGGCGNFQETHKNNPIYQFHIEKTG---------PLLIELRGPRQ------ 736
Query: 422 KRIGQGMLSIGYAVYQVPKELESHTDAHLGRDFFLAYQPSARTSTYVNLREVSGRARLPP 481
S+G+ V V T G FL + L +P
Sbjct: 737 -------YSVGFEVVTV------STLGDPGPHGFLRKSSGDYRCGFCYLE----LENIPS 779
Query: 482 GEYLVVPSTFEPFKDGEFCL 501
G + ++PSTF P ++G F L
Sbjct: 780 GIFNIIPSTFLPKQEGPFFL 799
>gi|6912388 grancalcin, EF-hand calcium binding protein [Homo
sapiens]
Length = 217
Score = 92.0 bits (227), Expect = 2e-18
Identities = 63/206 (30%), Positives = 99/206 (48%), Gaps = 9/206 (4%)
Query: 497 GEFCLRVFSEKKAQAL-EIGDVVAGNPYE--PHPSEVDQEDDQFRRLFEKLAGKDSEITA 553
G F ++V + Q + E G + + Y + D F +AG+D E+ A
Sbjct: 11 GNFSIQVPGMQMGQPVPETGPAILLDGYSGPAYSDTYSSAGDSVYTYFSAVAGQDGEVDA 70
Query: 554 NALKILLNEAFSKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEFKTLWLKIQKYLEI 613
L+ L ++ T + F++ TCR MI++LD + TG +G FK LW + + E
Sbjct: 71 EELQRCLTQSGINGT---YSPFSLETCRIMIAMLDRDHTGKMGFNAFKELWAALNAWKEN 127
Query: 614 YWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLG-INFDSFVACMIRL 672
+ D + SGT++ HE+R A+ G+ L+ Q TI RY SK G I FD +VAC ++L
Sbjct: 128 FMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRY--SKNGRIFFDDYVACCVKL 185
Query: 673 ETLFKLFSLLDEDKDGMVQLSLAEWL 698
L F D + G ++L
Sbjct: 186 RALTDFFRKRDHLQQGSANFIYDDFL 211
>gi|7019485 programmed cell death 6 [Homo sapiens]
Length = 191
Score = 65.5 bits (158), Expect = 2e-10
Identities = 43/143 (30%), Positives = 70/143 (48%), Gaps = 4/143 (2%)
Query: 560 LNEAFSKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEFKTLWLKIQKYLEIYWETDY 619
L +A S T + FN T R +IS+ D + EF +W I + ++ D
Sbjct: 48 LQQALSNGT---WTPFNPVTVRSIISMFDRENKAGVNFSEFTGVWKYITDWQNVFRTYDR 104
Query: 620 NHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLG-INFDSFVACMIRLETLFKL 678
++SG ID +E++ AL G+ L+ Q + ++ G I FD F+ I L+ L +
Sbjct: 105 DNSGMIDKNELKQALSGFGYRLSDQFHDILIRKFDRQGRGQIAFDDFIQGCIVLQRLTDI 164
Query: 679 FSLLDEDKDGMVQLSLAEWLCCV 701
F D D+DG +Q+S ++L V
Sbjct: 165 FRRYDTDQDGWIQVSYEQYLSMV 187
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,260,450
Number of Sequences: 37866
Number of extensions: 1347353
Number of successful extensions: 3080
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 2933
Number of HSP's gapped (non-prelim): 77
length of query: 703
length of database: 18,247,518
effective HSP length: 109
effective length of query: 594
effective length of database: 14,120,124
effective search space: 8387353656
effective search space used: 8387353656
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.