Search of human proteins with 221316707

Search of human proteins with 221316707

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|221316707 NADPH dependent diflavin oxidoreductase 1 isoform
d [Homo sapiens]
         (521 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|221316707 NADPH dependent diflavin oxidoreductase 1 isoform d...  1058   0.0  
gi|7657393 NADPH dependent diflavin oxidoreductase 1 isoform b [...  1013   0.0  
gi|221316705 NADPH dependent diflavin oxidoreductase 1 isoform a...  1006   0.0  
gi|221316709 NADPH dependent diflavin oxidoreductase 1 isoform c...   992   0.0  
gi|127139033 cytochrome P450 reductase [Homo sapiens]                 258   1e-68
gi|40254422 nitric oxide synthase 3 isoform 1 [Homo sapiens]          182   5e-46
gi|24041029 nitric oxide synthase 2A [Homo sapiens]                   176   5e-44
gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens]          154   2e-37
gi|169790958 methionine synthase reductase isoform 1 [Homo sapiens]   145   9e-35
gi|169790956 methionine synthase reductase isoform 2 [Homo sapiens]   145   9e-35
gi|231571329 nitric oxide synthase 3 isoform 3 [Homo sapiens]          60   6e-09
gi|231571356 nitric oxide synthase 3 isoform 4 [Homo sapiens]          57   3e-08
gi|231571314 nitric oxide synthase 3 isoform 2 [Homo sapiens]          57   3e-08
gi|50726981 radical S-adenosyl methionine and flavodoxin domains...    47   4e-05
gi|224282123 tRNA-yW synthesizing protein 1 homolog B isoform 1 ...    35   0.17 
gi|27312029 hypothetical protein LOC145376 [Homo sapiens]              33   0.48 
gi|145587088 hypothetical protein LOC165186 [Homo sapiens]             33   0.83 
gi|89242137 Meckel syndrome, type 1 [Homo sapiens]                     30   7.0  
gi|223468693 hypothetical protein LOC100130361 [Homo sapiens]          29   9.1  
gi|223468690 hypothetical protein LOC100132994 [Homo sapiens]          29   9.1  
gi|124028529 symplekin [Homo sapiens]                                  29   9.1  
gi|148839346 seizure related 6 homolog isoform 2 [Homo sapiens]        29   9.1  
gi|148839280 seizure related 6 homolog isoform 1 [Homo sapiens]        29   9.1  

>gi|221316707 NADPH dependent diflavin oxidoreductase 1 isoform d
           [Homo sapiens]
          Length = 521

 Score = 1058 bits (2737), Expect = 0.0
 Identities = 521/521 (100%), Positives = 521/521 (100%)

Query: 1   MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 60
           MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT
Sbjct: 1   MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 60

Query: 61  TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120
           TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG
Sbjct: 61  TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120

Query: 121 GSALLPVCLGDDQHELGLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMI 180
           GSALLPVCLGDDQHELGLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMI
Sbjct: 121 GSALLPVCLGDDQHELGLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMI 180

Query: 181 SNQRVTGPSHFQDVRLIEFDILGSGISFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLF 240
           SNQRVTGPSHFQDVRLIEFDILGSGISFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLF
Sbjct: 181 SNQRVTGPSHFQDVRLIEFDILGSGISFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLF 240

Query: 241 MLQPREPDVSSPTRLPQPCSMRHLVSHYLDIASVPRRSFFELLACLSLHELEREKLLEFS 300
           MLQPREPDVSSPTRLPQPCSMRHLVSHYLDIASVPRRSFFELLACLSLHELEREKLLEFS
Sbjct: 241 MLQPREPDVSSPTRLPQPCSMRHLVSHYLDIASVPRRSFFELLACLSLHELEREKLLEFS 300

Query: 301 SAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHP 360
           SAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHP
Sbjct: 301 SAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHP 360

Query: 361 SRLQILVAVVQFQTRLKEPRRGLCSSWLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVI 420
           SRLQILVAVVQFQTRLKEPRRGLCSSWLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVI
Sbjct: 361 SRLQILVAVVQFQTRLKEPRRGLCSSWLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVI 420

Query: 421 MVGPGTGVAPFRAAIQERVAQGQTGNFLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAF 480
           MVGPGTGVAPFRAAIQERVAQGQTGNFLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAF
Sbjct: 421 MVGPGTGVAPFRAAIQERVAQGQTGNFLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAF 480

Query: 481 SREQEQKVYVQHRLRELGSLVWELLDRQATPSPCQRTSRKP 521
           SREQEQKVYVQHRLRELGSLVWELLDRQATPSPCQRTSRKP
Sbjct: 481 SREQEQKVYVQHRLRELGSLVWELLDRQATPSPCQRTSRKP 521


>gi|7657393 NADPH dependent diflavin oxidoreductase 1 isoform b
           [Homo sapiens]
          Length = 597

 Score = 1013 bits (2620), Expect = 0.0
 Identities = 508/542 (93%), Positives = 508/542 (93%), Gaps = 34/542 (6%)

Query: 1   MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 60
           MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT
Sbjct: 1   MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 60

Query: 61  TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120
           TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG
Sbjct: 61  TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120

Query: 121 GSALLPVCLGDDQHELG----------------------------------LPSKFTLLF 146
           GSALLPVCLGDDQHELG                                  LPSKFTLLF
Sbjct: 121 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 180

Query: 147 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 206
           LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI
Sbjct: 181 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 240

Query: 207 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 266
           SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS
Sbjct: 241 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 300

Query: 267 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 326
           HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF
Sbjct: 301 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 360

Query: 327 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS 386
           PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS
Sbjct: 361 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS 420

Query: 387 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 446
           WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN
Sbjct: 421 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 480

Query: 447 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQEQKVYVQHRLRELGSLVWELLD 506
           FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQEQKVYVQHRLRELGSLVWELLD
Sbjct: 481 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQEQKVYVQHRLRELGSLVWELLD 540

Query: 507 RQ 508
           RQ
Sbjct: 541 RQ 542


>gi|221316705 NADPH dependent diflavin oxidoreductase 1 isoform a
           [Homo sapiens]
          Length = 606

 Score = 1006 bits (2600), Expect = 0.0
 Identities = 508/551 (92%), Positives = 508/551 (92%), Gaps = 43/551 (7%)

Query: 1   MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 60
           MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT
Sbjct: 1   MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 60

Query: 61  TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120
           TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG
Sbjct: 61  TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120

Query: 121 GSALLPVCLGDDQHELG----------------------------------LPSKFTLLF 146
           GSALLPVCLGDDQHELG                                  LPSKFTLLF
Sbjct: 121 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 180

Query: 147 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 206
           LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI
Sbjct: 181 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 240

Query: 207 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 266
           SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS
Sbjct: 241 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 300

Query: 267 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 326
           HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF
Sbjct: 301 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 360

Query: 327 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS 386
           PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS
Sbjct: 361 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS 420

Query: 387 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 446
           WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN
Sbjct: 421 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 480

Query: 447 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSRE---------QEQKVYVQHRLREL 497
           FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSRE         QEQKVYVQHRLREL
Sbjct: 481 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQPPALFSALQEQKVYVQHRLREL 540

Query: 498 GSLVWELLDRQ 508
           GSLVWELLDRQ
Sbjct: 541 GSLVWELLDRQ 551


>gi|221316709 NADPH dependent diflavin oxidoreductase 1 isoform c
           [Homo sapiens]
          Length = 590

 Score =  992 bits (2564), Expect = 0.0
 Identities = 501/542 (92%), Positives = 501/542 (92%), Gaps = 41/542 (7%)

Query: 1   MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 60
           MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT
Sbjct: 1   MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 60

Query: 61  TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120
           TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG
Sbjct: 61  TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120

Query: 121 GSALLPVCLGDDQHELG----------------------------------LPSKFTLLF 146
           GSALLPVCLGDDQHELG                                  LPSKFTLLF
Sbjct: 121 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 180

Query: 147 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 206
           LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI
Sbjct: 181 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 240

Query: 207 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 266
           SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS
Sbjct: 241 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 300

Query: 267 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 326
           HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF
Sbjct: 301 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 360

Query: 327 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS 386
           PHTAAAIPPDYLLDLIPVIRPRAFSIASSLL       ILVAVVQFQTRLKEPRRGLCSS
Sbjct: 361 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLL-------ILVAVVQFQTRLKEPRRGLCSS 413

Query: 387 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 446
           WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN
Sbjct: 414 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 473

Query: 447 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQEQKVYVQHRLRELGSLVWELLD 506
           FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQEQKVYVQHRLRELGSLVWELLD
Sbjct: 474 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQEQKVYVQHRLRELGSLVWELLD 533

Query: 507 RQ 508
           RQ
Sbjct: 534 RQ 535


>gi|127139033 cytochrome P450 reductase [Homo sapiens]
          Length = 680

 Score =  258 bits (658), Expect = 1e-68
 Identities = 180/550 (32%), Positives = 283/550 (51%), Gaps = 57/550 (10%)

Query: 6   LLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNL-----INEPLVIFVCAT 60
           ++V +GSQTGTA++ + RL ++A R  +       + Y + +L     I+  LV+F  AT
Sbjct: 83  IIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCMAT 142

Query: 61  TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120
            G+GDP DN ++F+ ++   ++    L  + FAV GLG+ +Y  FN + K + +RL QLG
Sbjct: 143 YGEGDPTDNAQDFYDWLQETDVD---LSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLG 199

Query: 121 GSALLPVCLGDDQHELGLPSKFTLLFLQEAPS---------TGSEGQ------------- 158
              +  + LGDD   L     F     Q  P+         TG E               
Sbjct: 200 AQRIFELGLGDDDGNL--EEDFITWREQFWPAVCEHFGVEATGEESSIRQYELVVHTDID 257

Query: 159 ----------RVAHPGSQEPPSESK-PFLAPMISNQRVTGPSHFQDVRLIEFDILGSGIS 207
                     R+    +Q+PP ++K PFLA + +N+++   +  + +  +E DI  S I 
Sbjct: 258 AAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTE-RHLMHLELDISDSKIR 316

Query: 208 FAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVSH 267
           + +GD V + P+N +A V +  ++LG D D +  L   + + +     P P S R  +++
Sbjct: 317 YESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNKKHPFPCPTSYRTALTY 376

Query: 268 YLDIASVPRRSFFELLACLSLHELEREKL--LEFSSAQGQEELFEYCNRPRRTILEVLCD 325
           YLDI + PR +    LA  +    E+E L  +  SS +G+E    +    RR IL +L D
Sbjct: 377 YLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQD 436

Query: 326 FPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCS 385
            P  +   P D+L +L+P ++ R +SIASS   HP+ + I   VV+++T+     +G+ +
Sbjct: 437 CP--SLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRINKGVAT 494

Query: 386 SWLASLDP---GQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQG 442
           +WL + +P     G   VP++VR      P    TPVIMVGPGTGVAPF   IQER    
Sbjct: 495 NWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAWLR 554

Query: 443 QTG-----NFLFFGCRWRDQDFYWEAEWQELEKRDCLT-LIPAFSREQEQKVYVQHRLRE 496
           Q G       L++GCR  D+D+ +  E  +  +   LT L  AFSREQ  KVYVQH L++
Sbjct: 555 QQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSREQSHKVYVQHLLKQ 614

Query: 497 LGSLVWELLD 506
               +W+L++
Sbjct: 615 DREHLWKLIE 624


>gi|40254422 nitric oxide synthase 3 isoform 1 [Homo sapiens]
          Length = 1203

 Score =  182 bits (463), Expect = 5e-46
 Identities = 179/597 (29%), Positives = 267/597 (44%), Gaps = 113/597 (18%)

Query: 8    VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67
            +L+GS+TG AQ  +++LGR   R+    RV  +D Y VV+L +E LV+ V +T G GDPP
Sbjct: 522  ILYGSETGRAQSYAQQLGR-LFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPP 580

Query: 68   DNMKNF---------------------------------------WRFIFRKNLPST--- 85
            +N ++F                                       WR   RK   S+   
Sbjct: 581  ENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSISCSDPLVSSWR---RKRKESSNTD 637

Query: 86   ---ALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPVCLGDDQHELGLPSKF 142
               AL  + F V GLG  +Y  F   A+ +  RL +LGG  LL +  GD+    G    F
Sbjct: 638  SAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDEL--CGQEEAF 695

Query: 143  ---TLLFLQEAPST---GSEGQRVAHP--------------------GSQEPPS-----E 171
                    Q A  T   G + +  A                      G Q  P       
Sbjct: 696  RGWAQAAFQAACETFCVGEDAKAAARDIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVHR 755

Query: 172  SKPFLAPMISNQRVTGPSHFQDVRLIEFDILGS-GISFAAGDVVLIQPSNSAAHVQRFCQ 230
             K F A + S + +      +   L+  D  G  G+ +  GD + + P N    V+    
Sbjct: 756  RKMFQATIRSVENLQSSKSTRATILVRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLS 815

Query: 231  VLG-----LDPDQLFMLQPREPDVSSP-----TRLPQPCSMRHLVSHYLDIASVPRRSFF 280
             +       +P  +  L+   P    P      RLP PC++R  ++ +LDI S P     
Sbjct: 816  RVEDPPAPTEPVAVEQLEKGSPGGPPPGWVRDPRLP-PCTLRQALTFFLDITSPPSPQLL 874

Query: 281  ELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIPPDYLLD 340
             LL+ L+    E+++L   S    + E +++   P  T+LEVL  FP  + A+P   LL 
Sbjct: 875  RLLSTLAEEPREQQELEALSQDPRRYEEWKWFRCP--TLLEVLEQFP--SVALPAPLLLT 930

Query: 341  LIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTR--LKEPRRGLCSSWLASLDPGQGPV 398
             +P+++PR +S++S+  THP  + + VAV+ ++T+  L     G+CS+WL+ L PG    
Sbjct: 931  QLPLLQPRYYSVSSAPSTHPGEIHLTVAVLAYRTQDGLGPLHYGVCSTWLSQLKPGDP-- 988

Query: 399  RVPLWVRPG-SLAFPETPDTPVIMVGPGTGVAPFRAAIQERV----AQG--QTGNFLFFG 451
             VP ++R   S   P  P  P I+VGPGTG+APFR   QER+    ++G   T   L FG
Sbjct: 989  -VPCFIRGAPSFRLPPDPSLPCILVGPGTGIAPFRGFWQERLHDIESKGLQPTPMTLVFG 1047

Query: 452  CRWRDQDFYWEAEWQELEKRDCL-TLIPAFSREQEQ-KVYVQHRLR-ELGSLVWELL 505
            CR    D  +  E Q  ++R     ++ AFSRE +  K YVQ  LR EL + V  +L
Sbjct: 1048 CRCSQLDHLYRDEVQNAQQRGVFGRVLTAFSREPDNPKTYVQDILRTELAAEVHRVL 1104


>gi|24041029 nitric oxide synthase 2A [Homo sapiens]
          Length = 1153

 Score =  176 bits (446), Expect = 5e-44
 Identities = 166/556 (29%), Positives = 265/556 (47%), Gaps = 70/556 (12%)

Query: 5    QLLVLFGSQTGTAQDVSERLGREARRRRLGC----RVQALDSYPVVNLINEPLVIFVCAT 60
            ++ +LF ++TG ++ ++  LG         C    +V  +D Y +  L  E L++ V +T
Sbjct: 538  RVTILFATETGKSEALAWDLGA-----LFSCAFNPKVVCMDKYRLSCLEEERLLLVVTST 592

Query: 61   TGQGDPPDNMKNFWRFIFR-KNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQL 119
             G GD P N +   + +F  K L +    +  +AV GLG S Y +F   A  + ++L  L
Sbjct: 593  FGNGDCPGNGEKLKKSLFMLKELNN----KFRYAVFGLGSSMYPRFCAFAHDIDQKLSHL 648

Query: 120  GGSALLPVCLGDDQ--HELGLPSKFTLLFLQEAPSTGSEGQRVAH------------PGS 165
            G S L P+  GD+    E    S     F     +    G++               P  
Sbjct: 649  GASQLTPMGEGDELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSNVTWDPHH 708

Query: 166  QEPPSESKP---------------FLAPMISNQRVTGPSHFQDVRLIEFDIL-GSGISFA 209
                 +S+P               F   + S Q +  P+  +   L+E     G G+++ 
Sbjct: 709  YRLVQDSQPLDLSKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYL 768

Query: 210  AGDVVLIQPSNSAAHVQRFCQ--VLGLDPDQLFMLQPREPDVS---SPTRLPQPCSMRHL 264
             G+ + + P N  A VQ   +  V G  P Q   L+  +   S   S  RLP PCS+   
Sbjct: 769  PGEHLGVCPGNQPALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLP-PCSLSQA 827

Query: 265  VSHYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLC 324
            ++++LDI + P +   + LA ++  E ER++L E      +   +++ N P  T LEVL 
Sbjct: 828  LTYFLDITTPPTQLLLQKLAQVATEEPERQRL-EALCQPSEYSKWKFTNSP--TFLEVLE 884

Query: 325  DFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEP--RRG 382
            +FP  +  +   +LL  +P+++PR +SI+SS    P+ + + VAVV + TR  +     G
Sbjct: 885  EFP--SLRVSAGFLLSQLPILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHG 942

Query: 383  LCSSWLASLDPGQGPVRVPLWVRPGS-LAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQ 441
            +CS+WL SL P Q PV  P +VR  S    PE P  P I++GPGTG+APFR+  Q+R+  
Sbjct: 943  VCSTWLNSLKP-QDPV--PCFVRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHD 999

Query: 442  GQTGNF------LFFGCRWRDQDFYWEAEWQELEKRDCLTLI-PAFSR-EQEQKVYVQHR 493
             Q          L FGCR  D+D  ++ E  E+ ++  L  +  A+SR   + KVYVQ  
Sbjct: 1000 SQHKGVRGGRMTLVFGCRRPDEDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDI 1059

Query: 494  LR-ELGSLVWELLDRQ 508
            LR +L S V  +L ++
Sbjct: 1060 LRQQLASEVLRVLHKE 1075


>gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens]
          Length = 1434

 Score =  154 bits (388), Expect = 2e-37
 Identities = 160/604 (26%), Positives = 254/604 (42%), Gaps = 121/604 (20%)

Query: 8    VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67
            +L+ ++TG +Q  ++ L  E  +     +V +++ Y +V+L +E LV+ V +T G GDPP
Sbjct: 762  ILYATETGKSQAYAKTLC-EIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPP 820

Query: 68   DNMKNFWRFIFRKNLPSTA---------------------------------------LC 88
            +N + F   +     P++                                        L 
Sbjct: 821  ENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLA 880

Query: 89   QMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPV--------------------- 127
             + F+V GLG  +Y  F      +   L +LGG  +L +                     
Sbjct: 881  NVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVF 940

Query: 128  -------CLGDDQH------------ELGLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEP 168
                   C+GDD +                 +KF L F+ EAP   ++G    H      
Sbjct: 941  KAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPEL-TQGLSNVH------ 993

Query: 169  PSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSG-ISFAAGDVVLIQPSNSAAHVQR 227
              + +   A ++S Q +  P   +    +     GS  + +  GD + + P N    V  
Sbjct: 994  --KKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLVNA 1051

Query: 228  FCQVLGLDPD-----QLFMLQPREPDV------SSPTRLPQPCSMRHLVSHYLDIASVPR 276
              + L   P      ++ +L+ R   +      +   RLP PC++     +YLDI + P 
Sbjct: 1052 LIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLP-PCTIFQAFKYYLDITTPPT 1110

Query: 277  RSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIPPD 336
                +  A L+  E E+++LL  S    + E +++   P  TI+EVL +FP  +  +P  
Sbjct: 1111 PLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNP--TIVEVLEEFP--SIQMPAT 1166

Query: 337  YLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEP--RRGLCSSWLASLDPG 394
             LL  + +++PR +SI+SS   +P  + + VA+V ++TR  E     G+CSSWL  +   
Sbjct: 1167 LLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRI--- 1223

Query: 395  QGPVRVPLWVRPG-SLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGNF------ 447
            Q    VP +VR   S   P  P  P I+VGPGTG+APFR+  Q+R    Q          
Sbjct: 1224 QADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMV 1283

Query: 448  LFFGCRWRDQD-FYWEAEWQELEKRDCLTLIPAFSREQEQ-KVYVQHRLRE-LGSLVWEL 504
            L FGCR    D  Y E   Q   K     L  A+SRE ++ K YVQ  L+E L   V+  
Sbjct: 1284 LVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDILQEQLAESVYRA 1343

Query: 505  LDRQ 508
            L  Q
Sbjct: 1344 LKEQ 1347


>gi|169790958 methionine synthase reductase isoform 1 [Homo sapiens]
          Length = 698

 Score =  145 bits (366), Expect = 9e-35
 Identities = 117/408 (28%), Positives = 188/408 (46%), Gaps = 50/408 (12%)

Query: 137 GLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRL 196
           GLP ++  + LQE  S G E  +V+        S    F  P+    ++T     +   L
Sbjct: 244 GLPPEYLQVHLQE--SLGQEESQVS------VTSADPVFQVPISKAVQLTTNDAIKTTLL 295

Query: 197 IEFDILGSGISFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFML------QPREPDVS 250
           +E DI  +  S+  GD   +   NS + VQ   Q L L+  +   +        ++   +
Sbjct: 296 VELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLKIKADTKKKGAT 355

Query: 251 SPTRLPQPCSMRHLVSHYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFE 310
            P  +P  CS++ + +  L+I ++P+++F   L   +    E+ +L E  S QG  +   
Sbjct: 356 LPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSR 415

Query: 311 YCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVV 370
           +       +L++L  FP  +   P   LL+ +P ++PR +S ASS L HP +L  +  +V
Sbjct: 416 FVRDACACLLDLLLAFP--SCQPPLSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIV 473

Query: 371 QFQTRLKEP--RRGLCSSWLASL--------------DPGQGPVRVPLWVRP---GSLAF 411
           +F +       R+G+C+ WLA L              D G+  +   + + P    S   
Sbjct: 474 EFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKA-LAPKISISPRTTNSFHL 532

Query: 412 PETPDTPVIMVGPGTGVAPFRAAIQER---VAQGQTGNF----LFFGCRWRDQDFYWEAE 464
           P+ P  P+IMVGPGTG+APF   +Q R     Q   GNF    LFFGCR +D+D+ +  E
Sbjct: 533 PDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKE 592

Query: 465 WQELEKRDCLT-LIPAFSR------EQEQKVYVQHRLRELGSLVWELL 505
            +   K   LT L  +FSR      E+    YVQ  ++  G  V  +L
Sbjct: 593 LRHFLKHGILTHLKVSFSRDAPVGEEEAPAKYVQDNIQLHGQQVARIL 640



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 40/130 (30%), Positives = 63/130 (48%), Gaps = 3/130 (2%)

Query: 5   QLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINE--PLVIFVCATTG 62
           + L+L+ +Q G A+ ++E +  +A        +  +      +L  E  PLV+ V +TTG
Sbjct: 3   RFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVV-STTG 61

Query: 63  QGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGS 122
            GDPPD  + F + I  + LP      + + +LGLGDS Y  F    K + +RL +LG  
Sbjct: 62  TGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGAR 121

Query: 123 ALLPVCLGDD 132
                   DD
Sbjct: 122 HFYDTGHADD 131


>gi|169790956 methionine synthase reductase isoform 2 [Homo sapiens]
          Length = 725

 Score =  145 bits (366), Expect = 9e-35
 Identities = 117/408 (28%), Positives = 188/408 (46%), Gaps = 50/408 (12%)

Query: 137 GLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRL 196
           GLP ++  + LQE  S G E  +V+        S    F  P+    ++T     +   L
Sbjct: 271 GLPPEYLQVHLQE--SLGQEESQVS------VTSADPVFQVPISKAVQLTTNDAIKTTLL 322

Query: 197 IEFDILGSGISFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFML------QPREPDVS 250
           +E DI  +  S+  GD   +   NS + VQ   Q L L+  +   +        ++   +
Sbjct: 323 VELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLKIKADTKKKGAT 382

Query: 251 SPTRLPQPCSMRHLVSHYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFE 310
            P  +P  CS++ + +  L+I ++P+++F   L   +    E+ +L E  S QG  +   
Sbjct: 383 LPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSR 442

Query: 311 YCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVV 370
           +       +L++L  FP  +   P   LL+ +P ++PR +S ASS L HP +L  +  +V
Sbjct: 443 FVRDACACLLDLLLAFP--SCQPPLSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIV 500

Query: 371 QFQTRLKEP--RRGLCSSWLASL--------------DPGQGPVRVPLWVRP---GSLAF 411
           +F +       R+G+C+ WLA L              D G+  +   + + P    S   
Sbjct: 501 EFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKA-LAPKISISPRTTNSFHL 559

Query: 412 PETPDTPVIMVGPGTGVAPFRAAIQER---VAQGQTGNF----LFFGCRWRDQDFYWEAE 464
           P+ P  P+IMVGPGTG+APF   +Q R     Q   GNF    LFFGCR +D+D+ +  E
Sbjct: 560 PDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKE 619

Query: 465 WQELEKRDCLT-LIPAFSR------EQEQKVYVQHRLRELGSLVWELL 505
            +   K   LT L  +FSR      E+    YVQ  ++  G  V  +L
Sbjct: 620 LRHFLKHGILTHLKVSFSRDAPVGEEEAPAKYVQDNIQLHGQQVARIL 667



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 40/130 (30%), Positives = 63/130 (48%), Gaps = 3/130 (2%)

Query: 5   QLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINE--PLVIFVCATTG 62
           + L+L+ +Q G A+ ++E +  +A        +  +      +L  E  PLV+ V +TTG
Sbjct: 30  RFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVV-STTG 88

Query: 63  QGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGS 122
            GDPPD  + F + I  + LP      + + +LGLGDS Y  F    K + +RL +LG  
Sbjct: 89  TGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGAR 148

Query: 123 ALLPVCLGDD 132
                   DD
Sbjct: 149 HFYDTGHADD 158


>gi|231571329 nitric oxide synthase 3 isoform 3 [Homo sapiens]
          Length = 614

 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 34/82 (41%), Positives = 49/82 (59%), Gaps = 2/82 (2%)

Query: 8   VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67
           +L+GS+TG AQ  +++LGR   R+    RV  +D Y VV+L +E LV+ V +T G GDPP
Sbjct: 522 ILYGSETGRAQSYAQQLGR-LFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPP 580

Query: 68  DNMKNFWRFIFRKNLPSTALCQ 89
           +N +  W F     L S +  Q
Sbjct: 581 ENGER-WGFAMLPRLVSNSWVQ 601


>gi|231571356 nitric oxide synthase 3 isoform 4 [Homo sapiens]
          Length = 629

 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 29/62 (46%), Positives = 42/62 (67%), Gaps = 1/62 (1%)

Query: 8   VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67
           +L+GS+TG AQ  +++LGR   R+    RV  +D Y VV+L +E LV+ V +T G GDPP
Sbjct: 522 ILYGSETGRAQSYAQQLGR-LFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPP 580

Query: 68  DN 69
           +N
Sbjct: 581 EN 582


>gi|231571314 nitric oxide synthase 3 isoform 2 [Homo sapiens]
          Length = 596

 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 29/62 (46%), Positives = 42/62 (67%), Gaps = 1/62 (1%)

Query: 8   VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67
           +L+GS+TG AQ  +++LGR   R+    RV  +D Y VV+L +E LV+ V +T G GDPP
Sbjct: 522 ILYGSETGRAQSYAQQLGR-LFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPP 580

Query: 68  DN 69
           +N
Sbjct: 581 EN 582


>gi|50726981 radical S-adenosyl methionine and flavodoxin domains 1
           [Homo sapiens]
          Length = 732

 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 41/134 (30%), Positives = 65/134 (48%), Gaps = 10/134 (7%)

Query: 8   VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSY-PVVNLINEP----LVIFVCATTG 62
           + +GSQTGTA+  +  L        L   +  L  Y P  +LI E     + +F+ AT  
Sbjct: 81  IFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDDHLIEEVTSKNVCVFLVATYT 140

Query: 63  QGDPPDNMKNFWRFIFRKNLP----STALCQMDFAVLGLGDSSYAK-FNFVAKKLHRRLL 117
            G P ++ + F +++   ++      T L  M +AV GLG+S+YA  FN V K + + L 
Sbjct: 141 DGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLW 200

Query: 118 QLGGSALLPVCLGD 131
            LG   ++    GD
Sbjct: 201 MLGAHRVMSRGEGD 214


>gi|224282123 tRNA-yW synthesizing protein 1 homolog B isoform 1
           [Homo sapiens]
          Length = 668

 Score = 35.0 bits (79), Expect = 0.17
 Identities = 25/85 (29%), Positives = 45/85 (52%), Gaps = 5/85 (5%)

Query: 41  DSYPVVNLINEPLVIFVCATTGQGDPPDNMKNFWRFIFRKNLP----STALCQMDFAVLG 96
           D + +  + ++ + +F+ AT   G P ++ + F +++   ++      T L  M  AV G
Sbjct: 73  DDHLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRDAVFG 132

Query: 97  LGDSSYAK-FNFVAKKLHRRLLQLG 120
           LG+S+YA  FN V K + + L  LG
Sbjct: 133 LGNSAYASHFNKVGKNVDKWLWMLG 157


>gi|27312029 hypothetical protein LOC145376 [Homo sapiens]
          Length = 422

 Score = 33.5 bits (75), Expect = 0.48
 Identities = 27/81 (33%), Positives = 38/81 (46%), Gaps = 5/81 (6%)

Query: 1   MPSPQLLVLFGSQTGTAQDVSERLGREARRR---RLGCRVQALDSYP--VVNLINEPLVI 55
           M SP +  L  S    AQ+V E+   +   R    +   V  LDS P  VV ++ EP  +
Sbjct: 312 MRSPVMSTLLPSLREKAQNVFEKKYHQVDVRFPAEMQKHVGTLDSVPMPVVGILGEPRCL 371

Query: 56  FVCATTGQGDPPDNMKNFWRF 76
           F   T    DP +N K+F R+
Sbjct: 372 FNPHTLHPLDPEENTKSFGRY 392


>gi|145587088 hypothetical protein LOC165186 [Homo sapiens]
          Length = 1019

 Score = 32.7 bits (73), Expect = 0.83
 Identities = 18/35 (51%), Positives = 23/35 (65%), Gaps = 2/35 (5%)

Query: 370 VQFQTRLKEPR--RGLCSSWLASLDPGQGPVRVPL 402
           +Q + +LK+ R   GL +S  ASLDPG GP  VPL
Sbjct: 122 IQIKDKLKKRRLSEGLAASSRASLDPGGGPQGVPL 156


>gi|89242137 Meckel syndrome, type 1 [Homo sapiens]
          Length = 559

 Score = 29.6 bits (65), Expect = 7.0
 Identities = 17/58 (29%), Positives = 33/58 (56%), Gaps = 2/58 (3%)

Query: 293 REKLLEFSSAQGQEE--LFEYCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPR 348
           R+++L+  ++ G++   +F Y +  R T LE  C    TAA+  P +L++ +  +R R
Sbjct: 108 RQEILKLENSGGKKNRRIFTYTDSDRYTNLEEHCQRMTTAASEVPSFLVERMANVRRR 165


>gi|223468693 hypothetical protein LOC100130361 [Homo sapiens]
          Length = 514

 Score = 29.3 bits (64), Expect = 9.1
 Identities = 19/51 (37%), Positives = 25/51 (49%), Gaps = 7/51 (13%)

Query: 377 KEPRRGLCSSWLASLDPGQ----GPVRVPLWVRPGSLAFPETPDTPVIMVG 423
           K P RG  S W   +DP Q    GP R+P      S +  E+ D P++ VG
Sbjct: 172 KNPERGSKSRWSLRVDPQQPSAKGPTRLP---THDSDSADESSDLPLMKVG 219


>gi|223468690 hypothetical protein LOC100132994 [Homo sapiens]
          Length = 514

 Score = 29.3 bits (64), Expect = 9.1
 Identities = 19/51 (37%), Positives = 25/51 (49%), Gaps = 7/51 (13%)

Query: 377 KEPRRGLCSSWLASLDPGQ----GPVRVPLWVRPGSLAFPETPDTPVIMVG 423
           K P RG  S W   +DP Q    GP R+P      S +  E+ D P++ VG
Sbjct: 172 KNPERGSKSRWSLRVDPQQPSAKGPTRLP---THDSDSADESSDLPLMKVG 219


>gi|124028529 symplekin [Homo sapiens]
          Length = 1274

 Score = 29.3 bits (64), Expect = 9.1
 Identities = 43/205 (20%), Positives = 76/205 (37%), Gaps = 29/205 (14%)

Query: 206 ISFAAGDVVLIQPSNS---AAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMR 262
           +S  AGD++L+  S++     H  +F + L      +  L PR  D   P R        
Sbjct: 161 VSAMAGDIILLLDSDNDGIRTHAIKFVEGL------IVTLSPRMADSEIPRRQ------- 207

Query: 263 HLVSHYLDIASVPR-RSFFELLACLSLHELEREKLLEF------SSAQGQEELFEYCNRP 315
               H + +  +PR   + +        +   E+LL+F      SS      L    N  
Sbjct: 208 ---EHDISLDRIPRDHPYIQYNVLWEEGKAALEQLLKFMVHPAISSINLTTALGSLANIA 264

Query: 316 RRTIL---EVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQF 372
           R+  +   EV+  +    A +PP      +  +R        S+L HP+ L+    +   
Sbjct: 265 RQRPMFMSEVIQAYETLHANLPPTLAKSQVSSVRKNLKLHLLSVLKHPASLEFQAQITTL 324

Query: 373 QTRLKEPRRGLCSSWLASLDPGQGP 397
              L  P+  +  +  +S D  + P
Sbjct: 325 LVDLGTPQAEIARNMPSSKDTRKRP 349


>gi|148839346 seizure related 6 homolog isoform 2 [Homo sapiens]
          Length = 993

 Score = 29.3 bits (64), Expect = 9.1
 Identities = 15/38 (39%), Positives = 19/38 (50%)

Query: 146 FLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQ 183
           FLQE    G E  R A P   +PP+   P   P ++NQ
Sbjct: 76  FLQEGLEKGDEELRPALPFQPDPPAPFTPSPLPRLANQ 113


>gi|148839280 seizure related 6 homolog isoform 1 [Homo sapiens]
          Length = 994

 Score = 29.3 bits (64), Expect = 9.1
 Identities = 15/38 (39%), Positives = 19/38 (50%)

Query: 146 FLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQ 183
           FLQE    G E  R A P   +PP+   P   P ++NQ
Sbjct: 76  FLQEGLEKGDEELRPALPFQPDPPAPFTPSPLPRLANQ 113


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.139    0.429 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,094,264
Number of Sequences: 37866
Number of extensions: 1147056
Number of successful extensions: 2766
Number of sequences better than 10.0: 23
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 2700
Number of HSP's gapped (non-prelim): 37
length of query: 521
length of database: 18,247,518
effective HSP length: 107
effective length of query: 414
effective length of database: 14,195,856
effective search space: 5877084384
effective search space used: 5877084384
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.