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Search of human proteins with 19923327
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19923327 neuroepithelial cell transforming gene 1 isoform 2
[Homo sapiens]
(542 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19923327 neuroepithelial cell transforming gene 1 isoform 2 [... 1079 0.0
gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 ... 1022 0.0
gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [H... 558 e-159
gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 ... 556 e-158
gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 ... 555 e-158
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 122 1e-27
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 105 1e-22
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 105 1e-22
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens] 94 2e-19
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens] 94 2e-19
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 92 2e-18
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo... 89 1e-17
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [... 84 3e-16
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [... 84 3e-16
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [... 84 3e-16
gi|194473700 Src homology 3 domain-containing guanine nucleotide... 80 4e-15
gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens] 78 2e-14
gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens] 78 2e-14
gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens] 78 2e-14
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens] 77 5e-14
gi|222080070 pleckstrin homology domain-containing family G memb... 75 1e-13
gi|222080068 pleckstrin homology domain-containing family G memb... 75 1e-13
gi|222080066 pleckstrin homology domain-containing family G memb... 75 1e-13
gi|39930351 dynamin binding protein [Homo sapiens] 74 3e-13
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [... 74 3e-13
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ... 74 3e-13
gi|163792208 Rho guanine exchange factor 16 [Homo sapiens] 73 6e-13
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 73 8e-13
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 73 8e-13
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 73 8e-13
>gi|19923327 neuroepithelial cell transforming gene 1 isoform 2
[Homo sapiens]
Length = 542
Score = 1079 bits (2791), Expect = 0.0
Identities = 542/542 (100%), Positives = 542/542 (100%)
Query: 1 MVAHDETGGLLPIKRTIRVLDVNNQSFREQEEPSNKRVRPLARVTSLANLISPVRNGAVR 60
MVAHDETGGLLPIKRTIRVLDVNNQSFREQEEPSNKRVRPLARVTSLANLISPVRNGAVR
Sbjct: 1 MVAHDETGGLLPIKRTIRVLDVNNQSFREQEEPSNKRVRPLARVTSLANLISPVRNGAVR 60
Query: 61 RFGQTIQSFTLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIR 120
RFGQTIQSFTLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIR
Sbjct: 61 RFGQTIQSFTLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIR 120
Query: 121 RQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLT 180
RQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLT
Sbjct: 121 RQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLT 180
Query: 181 RIGEATKPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCL 240
RIGEATKPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCL
Sbjct: 181 RIGEATKPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCL 240
Query: 241 ESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDIN 300
ESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDIN
Sbjct: 241 ESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDIN 300
Query: 301 LKKGESECQYYIDKLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTR 360
LKKGESECQYYIDKLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTR
Sbjct: 301 LKKGESECQYYIDKLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTR 360
Query: 361 PVTRNERHSYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPS 420
PVTRNERHSYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPS
Sbjct: 361 PVTRNERHSYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPS 420
Query: 421 PAQSHTLQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLPELHEECEGNHPSARKLTA 480
PAQSHTLQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLPELHEECEGNHPSARKLTA
Sbjct: 421 PAQSHTLQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLPELHEECEGNHPSARKLTA 480
Query: 481 QRRASTVSSVTQVEVDENAYRCGSGMQMAEDSKSLKTHQTQPGIRRARDKALSGGKRKET 540
QRRASTVSSVTQVEVDENAYRCGSGMQMAEDSKSLKTHQTQPGIRRARDKALSGGKRKET
Sbjct: 481 QRRASTVSSVTQVEVDENAYRCGSGMQMAEDSKSLKTHQTQPGIRRARDKALSGGKRKET 540
Query: 541 LV 542
LV
Sbjct: 541 LV 542
>gi|114145479 neuroepithelial cell transforming gene 1 isoform 1
[Homo sapiens]
Length = 596
Score = 1022 bits (2642), Expect = 0.0
Identities = 516/529 (97%), Positives = 520/529 (98%)
Query: 14 KRTIRVLDVNNQSFREQEEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQSFTLRG 73
KR + DV + S + +EPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQSFTLRG
Sbjct: 68 KRREKDDDVVSLSSLDLKEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQSFTLRG 127
Query: 74 DHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQ 133
DHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQ
Sbjct: 128 DHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQ 187
Query: 134 DLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVE 193
DLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVE
Sbjct: 188 DLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVE 247
Query: 194 QIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSF 253
QIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSF
Sbjct: 248 QIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSF 307
Query: 254 LDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYID 313
LDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYID
Sbjct: 308 LDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYID 367
Query: 314 KLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNERHSYQVY 373
KLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNERHSYQVY
Sbjct: 368 KLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNERHSYQVY 427
Query: 374 RQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVF 433
RQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVF
Sbjct: 428 RQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVF 487
Query: 434 HKQQWFNCIRAAIAPFQSAGSPPELQGLPELHEECEGNHPSARKLTAQRRASTVSSVTQV 493
HKQQWFNCIRAAIAPFQSAGSPPELQGLPELHEECEGNHPSARKLTAQRRASTVSSVTQV
Sbjct: 488 HKQQWFNCIRAAIAPFQSAGSPPELQGLPELHEECEGNHPSARKLTAQRRASTVSSVTQV 547
Query: 494 EVDENAYRCGSGMQMAEDSKSLKTHQTQPGIRRARDKALSGGKRKETLV 542
EVDENAYRCGSGMQMAEDSKSLKTHQTQPGIRRARDKALSGGKRKETLV
Sbjct: 548 EVDENAYRCGSGMQMAEDSKSLKTHQTQPGIRRARDKALSGGKRKETLV 596
>gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [Homo
sapiens]
Length = 526
Score = 558 bits (1437), Expect = e-159
Identities = 269/419 (64%), Positives = 345/419 (82%), Gaps = 1/419 (0%)
Query: 28 REQEEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQ-SFTLRGDHRSPASAQKFSS 86
++ EEPSNKRV+PL+RVTSLANLI PV+ ++RF QT+Q S + R + R A + S
Sbjct: 29 KDAEEPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWS 88
Query: 87 RSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAY 146
R+ P+ KRR S LWSE D+ + + LT++EI+RQEAI+E+S+GE+DLIEDLKLA+KAY
Sbjct: 89 RNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAY 148
Query: 147 HDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVEQIGHILVSWLPRL 206
HDPMLKLSIM+E+EL IFG LDS IPLHE+LL+++ + KPDG+ E +G ILV WLP L
Sbjct: 149 HDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCL 208
Query: 207 NAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPL 266
++Y YCSNQ+AAKALLD KKQD RVQDFLQRCLESPFSRKLDLW+FLDIPRSRLVKYPL
Sbjct: 209 SSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPL 268
Query: 267 LLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPR 326
LL+EIL+HTP ++PD Q LE+AI IIQG++++IN K GESEC+YY ++L YL+E Q+D
Sbjct: 269 LLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSL 328
Query: 327 IEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNERHSYQVYRQPIPVQELVLED 386
I++S+VL CHGEL++ G KL++FLFQ++LV+TR VT NE+ YQ+YRQPIPV++L+LED
Sbjct: 329 IDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLED 388
Query: 387 LQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQQWFNCIRAA 445
LQDG+VR+GGS RGAFSN+E+ KN FR+ F + S +Q+H+LQAND F+KQQW NCIR A
Sbjct: 389 LQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQA 447
>gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2
[Homo sapiens]
Length = 532
Score = 556 bits (1433), Expect = e-158
Identities = 269/419 (64%), Positives = 343/419 (81%), Gaps = 1/419 (0%)
Query: 28 REQEEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQ-SFTLRGDHRSPASAQKFSS 86
R EPSNKRV+PL+RVTSLANLI PV+ ++RF QT+Q S + R + R A + S
Sbjct: 35 RRTREPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWS 94
Query: 87 RSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAY 146
R+ P+ KRR S LWSE D+ + + LT++EI+RQEAI+E+S+GE+DLIEDLKLA+KAY
Sbjct: 95 RNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAY 154
Query: 147 HDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVEQIGHILVSWLPRL 206
HDPMLKLSIM+E+EL IFG LDS IPLHE+LL+++ + KPDG+ E +G ILV WLP L
Sbjct: 155 HDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCL 214
Query: 207 NAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPL 266
++Y YCSNQ+AAKALLD KKQD RVQDFLQRCLESPFSRKLDLW+FLDIPRSRLVKYPL
Sbjct: 215 SSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPL 274
Query: 267 LLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPR 326
LL+EIL+HTP ++PD Q LE+AI IIQG++++IN K GESEC+YY ++L YL+E Q+D
Sbjct: 275 LLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSL 334
Query: 327 IEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNERHSYQVYRQPIPVQELVLED 386
I++S+VL CHGEL++ G KL++FLFQ++LV+TR VT NE+ YQ+YRQPIPV++L+LED
Sbjct: 335 IDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLED 394
Query: 387 LQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQQWFNCIRAA 445
LQDG+VR+GGS RGAFSN+E+ KN FR+ F + S +Q+H+LQAND F+KQQW NCIR A
Sbjct: 395 LQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQA 453
>gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1
[Homo sapiens]
Length = 558
Score = 555 bits (1429), Expect = e-158
Identities = 268/415 (64%), Positives = 342/415 (82%), Gaps = 1/415 (0%)
Query: 32 EPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQ-SFTLRGDHRSPASAQKFSSRSTV 90
EPSNKRV+PL+RVTSLANLI PV+ ++RF QT+Q S + R + R A + SR+
Sbjct: 65 EPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWSRNAA 124
Query: 91 PTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPM 150
P+ KRR S LWSE D+ + + LT++EI+RQEAI+E+S+GE+DLIEDLKLA+KAYHDPM
Sbjct: 125 PSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPM 184
Query: 151 LKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVEQIGHILVSWLPRLNAYR 210
LKLSIM+E+EL IFG LDS IPLHE+LL+++ + KPDG+ E +G ILV WLP L++Y
Sbjct: 185 LKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYD 244
Query: 211 GYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKE 270
YCSNQ+AAKALLD KKQD RVQDFLQRCLESPFSRKLDLW+FLDIPRSRLVKYPLLL+E
Sbjct: 245 SYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLRE 304
Query: 271 ILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPRIEAS 330
IL+HTP ++PD Q LE+AI IIQG++++IN K GESEC+YY ++L YL+E Q+D I++S
Sbjct: 305 ILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSS 364
Query: 331 KVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNERHSYQVYRQPIPVQELVLEDLQDG 390
+VL CHGEL++ G KL++FLFQ++LV+TR VT NE+ YQ+YRQPIPV++L+LEDLQDG
Sbjct: 365 RVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDG 424
Query: 391 DVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQQWFNCIRAA 445
+VR+GGS RGAFSN+E+ KN FR+ F + S +Q+H+LQAND F+KQQW NCIR A
Sbjct: 425 EVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQA 479
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 122 bits (305), Expect = 1e-27
Identities = 100/370 (27%), Positives = 176/370 (47%), Gaps = 55/370 (14%)
Query: 107 DITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFG 166
D+ + + LT E +RQ I+E+ E++ + DL+L + + P+++ +++E+E+ IF
Sbjct: 1224 DLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFV 1283
Query: 167 DLDSYIPLHEDLLTRIGEATKPDGT---VEQIGHILVSWLPRLNAYRGYCSNQLAAKALL 223
+ I + LL + K G V+ IG IL + LP + Y +CS QL AL+
Sbjct: 1284 NWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSRQLNGAALI 1343
Query: 224 DQKKQD-PRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDV 282
QK + P ++F++R P + + L SF+ P R+ +YPL++K IL++TP+ HPD
Sbjct: 1344 QQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDH 1403
Query: 283 QLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQR----DPRIEASKVLLCHGE 338
L+ A+ + + S +N E E D+LE++ + ++ + V C G
Sbjct: 1404 SHLKHALEKAEELCSQVNEGVREKENS---DRLEWIQAHVQCEGLSEQLVFNSVTNCLGP 1460
Query: 339 ---------LRSKSGHKLYIFLFQDILVLT------------RPVTRNERHSYQVYRQPI 377
++KS +LY FLF D L+LT + + Y++Y+ PI
Sbjct: 1461 RKFLHSGKLYKAKSNKELYGFLFNDFLLLTQITKPLGSSGTDKVFSPKSNLQYKMYKTPI 1520
Query: 378 PVQELVLEDLQD--GDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHK 435
+ E++++ D GD + IF I D + +TL+A + +
Sbjct: 1521 FLNEVLVKLPTDPSGD-----------------EPIFHISHID----RVYTLRAESINER 1559
Query: 436 QQWFNCIRAA 445
W I+AA
Sbjct: 1560 TAWVQKIKAA 1569
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 105 bits (261), Expect = 1e-22
Identities = 96/369 (26%), Positives = 170/369 (46%), Gaps = 52/369 (14%)
Query: 107 DITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFG 166
D+ +++ E +RQ I+E+ + E+ + DL+L + + M + ++E E+ IF
Sbjct: 1169 DLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFV 1228
Query: 167 DLDSYIPLHEDLLTRIGEATKPDGT---VEQIGHILVSWLPRLNAYRGYCSNQLAAKALL 223
+ I + LL + K G V+ IG IL + L + AY +CS QL ALL
Sbjct: 1229 NWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALL 1288
Query: 224 DQKK-QDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDV 282
QK +D ++FL++ P + + L SFL P R+ +YPLL++ IL++TP+ H D
Sbjct: 1289 QQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADH 1348
Query: 283 QLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPRIEASKV---------- 332
L+ A+ + + S +N E E D+LE++ + + +
Sbjct: 1349 SSLKLALERAEELCSQVNEGVREKENS---DRLEWIQAHVQCEGLAEQLIFNSLTNCLGP 1405
Query: 333 --LLCHGEL-RSKSGHKLYIFLFQDILVLTRPV-------------TRNERHSYQVYRQP 376
LL G+L ++KS +L+ FLF D L+LT V + +++Y+ P
Sbjct: 1406 RKLLHSGKLYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTP 1465
Query: 377 IPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQ 436
I + E++++ D S+ E FH + +TL+ +++ +
Sbjct: 1466 IFLNEVLVKLPTDP------------SSDEPV-------FHISHIDRVYTLRTDNINERT 1506
Query: 437 QWFNCIRAA 445
W I+AA
Sbjct: 1507 AWVQKIKAA 1515
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 105 bits (261), Expect = 1e-22
Identities = 96/369 (26%), Positives = 170/369 (46%), Gaps = 52/369 (14%)
Query: 107 DITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFG 166
D+ +++ E +RQ I+E+ + E+ + DL+L + + M + ++E E+ IF
Sbjct: 1196 DLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFV 1255
Query: 167 DLDSYIPLHEDLLTRIGEATKPDGT---VEQIGHILVSWLPRLNAYRGYCSNQLAAKALL 223
+ I + LL + K G V+ IG IL + L + AY +CS QL ALL
Sbjct: 1256 NWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALL 1315
Query: 224 DQKK-QDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDV 282
QK +D ++FL++ P + + L SFL P R+ +YPLL++ IL++TP+ H D
Sbjct: 1316 QQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADH 1375
Query: 283 QLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPRIEASKV---------- 332
L+ A+ + + S +N E E D+LE++ + + +
Sbjct: 1376 SSLKLALERAEELCSQVNEGVREKENS---DRLEWIQAHVQCEGLAEQLIFNSLTNCLGP 1432
Query: 333 --LLCHGEL-RSKSGHKLYIFLFQDILVLTRPV-------------TRNERHSYQVYRQP 376
LL G+L ++KS +L+ FLF D L+LT V + +++Y+ P
Sbjct: 1433 RKLLHSGKLYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTP 1492
Query: 377 IPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQ 436
I + E++++ D S+ E FH + +TL+ +++ +
Sbjct: 1493 IFLNEVLVKLPTDP------------SSDEPV-------FHISHIDRVYTLRTDNINERT 1533
Query: 437 QWFNCIRAA 445
W I+AA
Sbjct: 1534 AWVQKIKAA 1542
>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
Length = 979
Score = 94.4 bits (233), Expect = 2e-19
Identities = 84/344 (24%), Positives = 159/344 (46%), Gaps = 45/344 (13%)
Query: 127 EMSRGEQDLIEDLKLARKAYHDPMLKLSI------MSEEELTHIFGDLDSYIPLHEDLLT 180
E+ + E+D + L+ A+ M + + ++EE + +F +++ + +H++ L
Sbjct: 30 ELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKEFLK 89
Query: 181 RIGEATKPDGTVEQ-IGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRC 239
+ E P+ +Q +G + + + Y YCSN A+ LL + + ++ FL C
Sbjct: 90 VVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFLLNC 149
Query: 240 LESPFSRKLD--LWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLS 297
+ + D L +L P R+ KYPL+LKE+LK TP++H D + +A+ ++ V S
Sbjct: 150 MLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMKAVCS 209
Query: 298 DINLKKGESECQYYIDKLEYLDEKQRDPRIE----------ASKVLLCHGELRSKSGH-- 345
+IN E + ++KLE L+E Q IE +++L+C L+ SG+
Sbjct: 210 NIN------EAKRQMEKLEVLEEWQ--SHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQ 261
Query: 346 KLYIFLFQDILVLTRPVTRNERHS-------YQVYRQPIPVQELVLEDLQDGDVRMGGSF 398
+ FLF ++LV + R ++S ++R I + + +E++ DG
Sbjct: 262 ERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADF---- 317
Query: 399 RGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQQWFNCI 442
S+ N ++I H+ + + A K +WF I
Sbjct: 318 ---HSSGHIVVNGWKI--HNTAKNKWFVCMAKTPEEKHEWFEAI 356
>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
Length = 1606
Score = 94.4 bits (233), Expect = 2e-19
Identities = 84/344 (24%), Positives = 159/344 (46%), Gaps = 45/344 (13%)
Query: 127 EMSRGEQDLIEDLKLARKAYHDPMLKLSI------MSEEELTHIFGDLDSYIPLHEDLLT 180
E+ + E+D + L+ A+ M + + ++EE + +F +++ + +H++ L
Sbjct: 30 ELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKEFLK 89
Query: 181 RIGEATKPDGTVEQ-IGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRC 239
+ E P+ +Q +G + + + Y YCSN A+ LL + + ++ FL C
Sbjct: 90 VVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFLLNC 149
Query: 240 LESPFSRKLD--LWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLS 297
+ + D L +L P R+ KYPL+LKE+LK TP++H D + +A+ ++ V S
Sbjct: 150 MLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMKAVCS 209
Query: 298 DINLKKGESECQYYIDKLEYLDEKQRDPRIE----------ASKVLLCHGELRSKSGH-- 345
+IN E + ++KLE L+E Q IE +++L+C L+ SG+
Sbjct: 210 NIN------EAKRQMEKLEVLEEWQ--SHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQ 261
Query: 346 KLYIFLFQDILVLTRPVTRNERHS-------YQVYRQPIPVQELVLEDLQDGDVRMGGSF 398
+ FLF ++LV + R ++S ++R I + + +E++ DG
Sbjct: 262 ERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADF---- 317
Query: 399 RGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQQWFNCI 442
S+ N ++I H+ + + A K +WF I
Sbjct: 318 ---HSSGHIVVNGWKI--HNTAKNKWFVCMAKTPEEKHEWFEAI 356
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 91.7 bits (226), Expect = 2e-18
Identities = 75/306 (24%), Positives = 141/306 (46%), Gaps = 28/306 (9%)
Query: 156 MSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVE-QIGHILVSWLPRLNAYRGYCS 214
++EE + +F +++ + +H+D L + P+ + ++G++ + + + Y YCS
Sbjct: 91 LTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCS 150
Query: 215 NQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLD--LWSFLDIPRSRLVKYPLLLKEIL 272
N A LL + + P V+ FL C+ + D L +L P R+ KYPLLLKE+
Sbjct: 151 NHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELA 210
Query: 273 KHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLE-YLDEKQRDPRIEASK 331
K TP +HPD ++ A+ ++ V S+IN K + E +++L+ +++ + +
Sbjct: 211 KRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICT 270
Query: 332 VLLCHGELRSKSGHKLY---IFLFQDILVLTR------------PVTRNERHSYQVYRQP 376
LL G L S + FLF ++LV + T++ S ++R
Sbjct: 271 QLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGR 330
Query: 377 IPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQ 436
I + + +E+++DG SN N ++I H+ + + A KQ
Sbjct: 331 INTEVMEVENVEDGTA-------DYHSNGYTVTNGWKI--HNTAKNKWFVCMAKTAEEKQ 381
Query: 437 QWFNCI 442
+W + I
Sbjct: 382 KWLDAI 387
>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
sapiens]
Length = 1544
Score = 88.6 bits (218), Expect = 1e-17
Identities = 78/281 (27%), Positives = 129/281 (45%), Gaps = 24/281 (8%)
Query: 102 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEEL 161
W +++ + L EI+RQE I E+ E+ + LK+ + ++ + + I+S EL
Sbjct: 769 WQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSEL 828
Query: 162 THIFGDLDSYIPLHEDLLTRIGEATKPDGT--VEQIGHILVSWLPR------LNAYRGYC 213
IF +L+ + LH L ++ K + T ++QIG L++W +A +C
Sbjct: 829 RKIFSNLEDILQLHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFC 888
Query: 214 SNQ-LAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEIL 272
SNQ A + + ++K+D R Q F+Q +P R+L L + RL KYPLLL I
Sbjct: 889 SNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIA 948
Query: 273 KHT--PKEHPDVQLLED-AILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRD-PRIE 328
K+T P E V+ D I+ V + + + + Y +L+ K + P +E
Sbjct: 949 KYTEWPTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVE 1008
Query: 329 -------ASKVLLCHGELRSKSGH----KLYIFLFQDILVL 358
+ ++ G L K LY L +DILVL
Sbjct: 1009 ELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVL 1049
>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1
[Homo sapiens]
Length = 927
Score = 84.3 bits (207), Expect = 3e-16
Identities = 91/366 (24%), Positives = 159/366 (43%), Gaps = 41/366 (11%)
Query: 102 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEEL 161
W E++ SL +++RQE I E+ E + L++ + PM + EEL
Sbjct: 413 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 472
Query: 162 THIFGDLDSYIPLHEDLLTRIGEATKPDG-TVEQIGHILV--------SWLPRLNAYRGY 212
+IF LD I +H L R+ + + G +E+IG +L+ SW ++++ +
Sbjct: 473 QNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISS--RF 530
Query: 213 CSNQ-LAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEI 271
CS Q A + L ++++DPR F+Q P R+L L + RL KYPLLL+ I
Sbjct: 531 CSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSI 590
Query: 272 LKHT--PKEHPDVQLLEDAILIIQGVLSDINLKKGESE----CQYYIDKLEYLDEKQ-RD 324
++T P E V+L + + +L +N + E + Y +L+ +Q D
Sbjct: 591 GQNTEEPTEREKVELAAEC---CREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSD 647
Query: 325 P------RIEASKVLLCH-----GELRSKSGHKLYIFLFQD-ILVLTRPVTRNERHSYQV 372
P ++ +K L H + ++++ L D +L+L R R S+
Sbjct: 648 PMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSR 707
Query: 373 YRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDV 432
P P + +L + +R+ + + KA F + F AQ + L A V
Sbjct: 708 TLTPTPDGKTMLRPV----LRLTSAMTREVATDHKA---FYVLFTWDQEAQIYELVAQTV 760
Query: 433 FHKQQW 438
++ W
Sbjct: 761 SERKNW 766
>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3
[Homo sapiens]
Length = 879
Score = 84.3 bits (207), Expect = 3e-16
Identities = 91/366 (24%), Positives = 159/366 (43%), Gaps = 41/366 (11%)
Query: 102 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEEL 161
W E++ SL +++RQE I E+ E + L++ + PM + EEL
Sbjct: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 424
Query: 162 THIFGDLDSYIPLHEDLLTRIGEATKPDG-TVEQIGHILV--------SWLPRLNAYRGY 212
+IF LD I +H L R+ + + G +E+IG +L+ SW ++++ +
Sbjct: 425 QNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISS--RF 482
Query: 213 CSNQ-LAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEI 271
CS Q A + L ++++DPR F+Q P R+L L + RL KYPLLL+ I
Sbjct: 483 CSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSI 542
Query: 272 LKHT--PKEHPDVQLLEDAILIIQGVLSDINLKKGESE----CQYYIDKLEYLDEKQ-RD 324
++T P E V+L + + +L +N + E + Y +L+ +Q D
Sbjct: 543 GQNTEEPTEREKVELAAEC---CREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSD 599
Query: 325 P------RIEASKVLLCH-----GELRSKSGHKLYIFLFQD-ILVLTRPVTRNERHSYQV 372
P ++ +K L H + ++++ L D +L+L R R S+
Sbjct: 600 PMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSR 659
Query: 373 YRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDV 432
P P + +L + +R+ + + KA F + F AQ + L A V
Sbjct: 660 TLTPTPDGKTMLRPV----LRLTSAMTREVATDHKA---FYVLFTWDQEAQIYELVAQTV 712
Query: 433 FHKQQW 438
++ W
Sbjct: 713 SERKNW 718
>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2
[Homo sapiens]
Length = 912
Score = 84.3 bits (207), Expect = 3e-16
Identities = 91/366 (24%), Positives = 159/366 (43%), Gaps = 41/366 (11%)
Query: 102 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEEL 161
W E++ SL +++RQE I E+ E + L++ + PM + EEL
Sbjct: 398 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 457
Query: 162 THIFGDLDSYIPLHEDLLTRIGEATKPDG-TVEQIGHILV--------SWLPRLNAYRGY 212
+IF LD I +H L R+ + + G +E+IG +L+ SW ++++ +
Sbjct: 458 QNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISS--RF 515
Query: 213 CSNQ-LAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEI 271
CS Q A + L ++++DPR F+Q P R+L L + RL KYPLLL+ I
Sbjct: 516 CSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSI 575
Query: 272 LKHT--PKEHPDVQLLEDAILIIQGVLSDINLKKGESE----CQYYIDKLEYLDEKQ-RD 324
++T P E V+L + + +L +N + E + Y +L+ +Q D
Sbjct: 576 GQNTEEPTEREKVELAAEC---CREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSD 632
Query: 325 P------RIEASKVLLCH-----GELRSKSGHKLYIFLFQD-ILVLTRPVTRNERHSYQV 372
P ++ +K L H + ++++ L D +L+L R R S+
Sbjct: 633 PMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSR 692
Query: 373 YRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDV 432
P P + +L + +R+ + + KA F + F AQ + L A V
Sbjct: 693 TLTPTPDGKTMLRPV----LRLTSAMTREVATDHKA---FYVLFTWDQEAQIYELVAQTV 745
Query: 433 FHKQQW 438
++ W
Sbjct: 746 SERKNW 751
>gi|194473700 Src homology 3 domain-containing guanine nucleotide
exchange factor [Homo sapiens]
Length = 871
Score = 80.5 bits (197), Expect = 4e-15
Identities = 75/337 (22%), Positives = 150/337 (44%), Gaps = 28/337 (8%)
Query: 67 QSFTLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMK---ESLTTREIRRQE 123
++ + D S QK + + R + WS++ + K ++++ E +RQE
Sbjct: 386 KALDIDSDEESEPKEQKSDEKIVIHHKPLRST---WSQLSAVKRKGLSQTVSQEERKRQE 442
Query: 124 AIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIG 183
AI+E+ E + L++ + + + M++ E H+F ++ + +
Sbjct: 443 AIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNITDVCEASKKFFIELE 502
Query: 184 EATKPDGTVEQIGHILVSWLPR-LNAYRGYCSNQLAAKALLDQK-KQDPRVQDFLQRCLE 241
+ + ++ I I+ + Y YC+N++ + L + +P ++ L R
Sbjct: 503 ARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLSRIES 562
Query: 242 SPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDIN- 300
R L + SFL +P R+ + PLL+ I + TPK+ P ++ + A+ + ++ N
Sbjct: 563 HEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEVSKLVRLCNE 622
Query: 301 --LKKGESECQYYID-KLEYLDEKQRDPRIEASKVLLCHGEL-----------RSKSGHK 346
K +E Y I+ +LE+ + + P + +S+ L+ GEL R S +
Sbjct: 623 GARKMERTEMMYTINSQLEF--KIKPFPLVSSSRWLVKRGELTAYVEDTVLFSRRTSKQQ 680
Query: 347 LYIFLFQDILVLTRPVTRNERHSYQVYRQPIPVQELV 383
+Y FLF D+L++T+ + SY V + Q LV
Sbjct: 681 VYFFLFNDVLIITK---KKSEESYNVNDYSLRDQLLV 714
>gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]
Length = 2817
Score = 77.8 bits (190), Expect = 2e-14
Identities = 100/480 (20%), Positives = 201/480 (41%), Gaps = 67/480 (13%)
Query: 94 AKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKL 153
+K+ + WS ++D + ++RQE IYE+ + E + LK+ Y M+
Sbjct: 1972 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 2031
Query: 154 SIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATK--------PDGTVEQIGHILVSWLPR 205
+ ++ + +F LD I +H RI E K + +++IG +LV+
Sbjct: 2032 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 2091
Query: 206 LNA------YRGYC-SNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPR 258
NA Y +C + + D +D R Q F+++ + S R+L + + +
Sbjct: 2092 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 2151
Query: 259 SRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYL 318
R+ KYP+L + IL+ T + + L ++ +++ V+ ++ K E + ++++
Sbjct: 2152 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTK 2211
Query: 319 DEKQRDPRIEAS----------KVLLCHGE--LRSKSGH--KLYIFLFQDILVLTRPVTR 364
+ + R+++ K L+ G L++ +G ++ L DILV + +
Sbjct: 2212 TDSKSIMRMKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQ--EK 2269
Query: 365 NERHSYQVYRQP---IPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSP 421
++++ + Q I +++L++ ++ ++ EK + + DP
Sbjct: 2270 DQKYIFASLDQKSTVISLKKLIVREV---------------AHEEKGLFLISMGMTDPEM 2314
Query: 422 AQSHTLQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLP-ELHEECEGNHPSARKLTA 480
+ H A+ + W I+ I + + E +G+P E EE + AR+L
Sbjct: 2315 VEVH---ASSKEERNSWIQIIQDTI----NTLNRDEDEGIPSENEEEKKMLDTRARELKE 2367
Query: 481 QRRASTVSSVTQVEVDENAYRCGSGMQMAEDSKSL-----KTHQTQPGIRRARDKALSGG 535
Q + +E E +R MAE S L TH + R ++AL GG
Sbjct: 2368 QLHQKDQKILLLLEEKEMIFR-----DMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGG 2422
>gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]
Length = 1058
Score = 77.8 bits (190), Expect = 2e-14
Identities = 100/480 (20%), Positives = 201/480 (41%), Gaps = 67/480 (13%)
Query: 94 AKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKL 153
+K+ + WS ++D + ++RQE IYE+ + E + LK+ Y M+
Sbjct: 213 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 272
Query: 154 SIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATK--------PDGTVEQIGHILVSWLPR 205
+ ++ + +F LD I +H RI E K + +++IG +LV+
Sbjct: 273 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 332
Query: 206 LNA------YRGYC-SNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPR 258
NA Y +C + + D +D R Q F+++ + S R+L + + +
Sbjct: 333 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 392
Query: 259 SRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYL 318
R+ KYP+L + IL+ T + + L ++ +++ V+ ++ K E + ++++
Sbjct: 393 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTK 452
Query: 319 DEKQRDPRIEAS----------KVLLCHGE--LRSKSGH--KLYIFLFQDILVLTRPVTR 364
+ + R+++ K L+ G L++ +G ++ L DILV + +
Sbjct: 453 TDSKSIMRMKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQ--EK 510
Query: 365 NERHSYQVYRQP---IPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSP 421
++++ + Q I +++L++ ++ ++ EK + + DP
Sbjct: 511 DQKYIFASLDQKSTVISLKKLIVREV---------------AHEEKGLFLISMGMTDPEM 555
Query: 422 AQSHTLQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLP-ELHEECEGNHPSARKLTA 480
+ H A+ + W I+ I + + E +G+P E EE + AR+L
Sbjct: 556 VEVH---ASSKEERNSWIQIIQDTI----NTLNRDEDEGIPSENEEEKKMLDTRARELKE 608
Query: 481 QRRASTVSSVTQVEVDENAYRCGSGMQMAEDSKSL-----KTHQTQPGIRRARDKALSGG 535
Q + +E E +R MAE S L TH + R ++AL GG
Sbjct: 609 QLHQKDQKILLLLEEKEMIFR-----DMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGG 663
>gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]
Length = 2813
Score = 77.8 bits (190), Expect = 2e-14
Identities = 100/480 (20%), Positives = 201/480 (41%), Gaps = 67/480 (13%)
Query: 94 AKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKL 153
+K+ + WS ++D + ++RQE IYE+ + E + LK+ Y M+
Sbjct: 1968 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 2027
Query: 154 SIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATK--------PDGTVEQIGHILVSWLPR 205
+ ++ + +F LD I +H RI E K + +++IG +LV+
Sbjct: 2028 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 2087
Query: 206 LNA------YRGYC-SNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPR 258
NA Y +C + + D +D R Q F+++ + S R+L + + +
Sbjct: 2088 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 2147
Query: 259 SRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYL 318
R+ KYP+L + IL+ T + + L ++ +++ V+ ++ K E + ++++
Sbjct: 2148 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTK 2207
Query: 319 DEKQRDPRIEAS----------KVLLCHGE--LRSKSGH--KLYIFLFQDILVLTRPVTR 364
+ + R+++ K L+ G L++ +G ++ L DILV + +
Sbjct: 2208 TDSKSIMRMKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQ--EK 2265
Query: 365 NERHSYQVYRQP---IPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSP 421
++++ + Q I +++L++ ++ ++ EK + + DP
Sbjct: 2266 DQKYIFASLDQKSTVISLKKLIVREV---------------AHEEKGLFLISMGMTDPEM 2310
Query: 422 AQSHTLQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLP-ELHEECEGNHPSARKLTA 480
+ H A+ + W I+ I + + E +G+P E EE + AR+L
Sbjct: 2311 VEVH---ASSKEERNSWIQIIQDTI----NTLNRDEDEGIPSENEEEKKMLDTRARELKE 2363
Query: 481 QRRASTVSSVTQVEVDENAYRCGSGMQMAEDSKSL-----KTHQTQPGIRRARDKALSGG 535
Q + +E E +R MAE S L TH + R ++AL GG
Sbjct: 2364 QLHQKDQKILLLLEEKEMIFR-----DMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGG 2418
>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
Length = 516
Score = 76.6 bits (187), Expect = 5e-14
Identities = 84/344 (24%), Positives = 144/344 (41%), Gaps = 33/344 (9%)
Query: 114 LTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIM-SEEELTHIFGDLDSYI 172
L R+ R I E+ E+ I+ LK + Y K M S+E+L IFG+++
Sbjct: 97 LQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIY 156
Query: 173 PLHEDLLTRIGEA-TKPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPR 231
+ + + D + +IG + Y YC+N L A L + +D R
Sbjct: 157 RFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSR 216
Query: 232 VQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILI 291
Q F + C + + FL P ++ KYPL L E+LK+T ++H D + + A+ +
Sbjct: 217 YQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAV 276
Query: 292 IQGVLSDINLKKGESECQYYIDKL-----EYLDEKQRDPRIEASKVLLCHGELR------ 340
++ V IN +K E IDK+ LD + D ++ S L+ GE+
Sbjct: 277 MRNVTQQINERKRRLE---NIDKIAQWQASVLDWEGED-ILDRSSELIYTGEMAWIYQPY 332
Query: 341 SKSGHKLYIFLFQDILVLTRPVTRNERHSYQVYRQPIPVQELVLEDLQDG-DVRMGGSFR 399
++ +++ FLF +VL + R Y+ I + + + D++DG D S +
Sbjct: 333 GRNQQRVF-FLFDHQMVLCKKDL--IRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMK 389
Query: 400 GAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQQWFNCIR 443
AF + H+ + H A + K +W R
Sbjct: 390 NAF------------KLHNKETEEIHLFFAKKLEEKIRWLRAFR 421
>gi|222080070 pleckstrin homology domain-containing family G member
6 isoform b [Homo sapiens]
Length = 758
Score = 75.5 bits (184), Expect = 1e-13
Identities = 82/329 (24%), Positives = 150/329 (45%), Gaps = 46/329 (13%)
Query: 102 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLS---IMSE 158
W E+ + + ++ +QEA++E+ E + LK+ +L L ++ E
Sbjct: 113 WREL--VPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLME 170
Query: 159 EELTHIFGDLDSYIPLH----EDLLTRIGEATKPDGT-VEQIG--HILVSWLPRLNAYRG 211
+FG++ S I H +++L E T+ G ++ IG +++ R + Y
Sbjct: 171 VSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQ 230
Query: 212 YCSNQLAAKALL-DQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKE 270
YC A +Q++ +P F+Q C + S + L L P R+ KYPLLL
Sbjct: 231 YCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHA 290
Query: 271 ILKHTPKEHPDVQLLEDAILIIQGVLSDIN--LKKGESE-----CQYYIDKLEYL----D 319
+LK +P+ + L I ++ L IN +++GE + I E L D
Sbjct: 291 VLKRSPEARAQ-EALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSD 349
Query: 320 EKQRDPR---------------IEASKVLLCHGELRSKSGHK----LYIFLFQDILVLTR 360
E +++ R E ++ LL G +R K G + +Y+FLF D+L++T+
Sbjct: 350 EVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTK 409
Query: 361 PVTRNERHSYQVYRQPIPVQELVLEDLQD 389
P + ++ +V R P+ +++LV + L+D
Sbjct: 410 PQRKADK--AKVIRPPLMLEKLVCQPLRD 436
>gi|222080068 pleckstrin homology domain-containing family G member
6 isoform a [Homo sapiens]
Length = 790
Score = 75.5 bits (184), Expect = 1e-13
Identities = 82/329 (24%), Positives = 150/329 (45%), Gaps = 46/329 (13%)
Query: 102 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLS---IMSE 158
W E+ + + ++ +QEA++E+ E + LK+ +L L ++ E
Sbjct: 145 WREL--VPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLME 202
Query: 159 EELTHIFGDLDSYIPLH----EDLLTRIGEATKPDGT-VEQIG--HILVSWLPRLNAYRG 211
+FG++ S I H +++L E T+ G ++ IG +++ R + Y
Sbjct: 203 VSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQ 262
Query: 212 YCSNQLAAKALL-DQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKE 270
YC A +Q++ +P F+Q C + S + L L P R+ KYPLLL
Sbjct: 263 YCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHA 322
Query: 271 ILKHTPKEHPDVQLLEDAILIIQGVLSDIN--LKKGESE-----CQYYIDKLEYL----D 319
+LK +P+ + L I ++ L IN +++GE + I E L D
Sbjct: 323 VLKRSPEARAQ-EALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSD 381
Query: 320 EKQRDPR---------------IEASKVLLCHGELRSKSGHK----LYIFLFQDILVLTR 360
E +++ R E ++ LL G +R K G + +Y+FLF D+L++T+
Sbjct: 382 EVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTK 441
Query: 361 PVTRNERHSYQVYRQPIPVQELVLEDLQD 389
P + ++ +V R P+ +++LV + L+D
Sbjct: 442 PQRKADK--AKVIRPPLMLEKLVCQPLRD 468
>gi|222080066 pleckstrin homology domain-containing family G member
6 isoform a [Homo sapiens]
Length = 790
Score = 75.5 bits (184), Expect = 1e-13
Identities = 82/329 (24%), Positives = 150/329 (45%), Gaps = 46/329 (13%)
Query: 102 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLS---IMSE 158
W E+ + + ++ +QEA++E+ E + LK+ +L L ++ E
Sbjct: 145 WREL--VPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLME 202
Query: 159 EELTHIFGDLDSYIPLH----EDLLTRIGEATKPDGT-VEQIG--HILVSWLPRLNAYRG 211
+FG++ S I H +++L E T+ G ++ IG +++ R + Y
Sbjct: 203 VSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQ 262
Query: 212 YCSNQLAAKALL-DQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKE 270
YC A +Q++ +P F+Q C + S + L L P R+ KYPLLL
Sbjct: 263 YCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHA 322
Query: 271 ILKHTPKEHPDVQLLEDAILIIQGVLSDIN--LKKGESE-----CQYYIDKLEYL----D 319
+LK +P+ + L I ++ L IN +++GE + I E L D
Sbjct: 323 VLKRSPEARAQ-EALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSD 381
Query: 320 EKQRDPR---------------IEASKVLLCHGELRSKSGHK----LYIFLFQDILVLTR 360
E +++ R E ++ LL G +R K G + +Y+FLF D+L++T+
Sbjct: 382 EVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTK 441
Query: 361 PVTRNERHSYQVYRQPIPVQELVLEDLQD 389
P + ++ +V R P+ +++LV + L+D
Sbjct: 442 PQRKADK--AKVIRPPLMLEKLVCQPLRD 468
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 74.3 bits (181), Expect = 3e-13
Identities = 54/190 (28%), Positives = 97/190 (51%), Gaps = 17/190 (8%)
Query: 120 RRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLL 179
+R + I E+ + E+D I DL++ + PM + + + + +FG++ I + + LL
Sbjct: 784 KRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQVPNID-FEGLFGNMQMVIKVSKQLL 842
Query: 180 TRIGEATKPDGTVEQIGHILVSWLPRLNA-YRGYCSNQLAAKALLDQKKQDPRVQDFLQR 238
+ + + +G + + L Y+ YC N A ALL+ ++D ++Q LQ
Sbjct: 843 AALEIS-------DAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQD 895
Query: 239 CL--------ESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAIL 290
L E + ++L SFL P R+++YPLLL E+L TP+ HPD L +A+L
Sbjct: 896 SLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVL 955
Query: 291 IIQGVLSDIN 300
++ + +IN
Sbjct: 956 AVKEINVNIN 965
>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 839
Score = 74.3 bits (181), Expect = 3e-13
Identities = 73/298 (24%), Positives = 140/298 (46%), Gaps = 37/298 (12%)
Query: 93 PAKRRSSALWSEMLDITMKESLT---TREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDP 149
P + ++ +++ + +++ + T + +R + E+ E L+ K Y P
Sbjct: 163 PCEDGGDDIYEDIIKVEVQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSP 222
Query: 150 MLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVEQIGHILVSWLPRLNAY 209
L+L ++S ++ +F +L+ I +H L I + G+ + + + + RL Y
Sbjct: 223 -LRL-VLSPADMAAVFINLEDLIKVHHSFLRAIDVSVMVGGST--LAKVFLDFKERLLIY 278
Query: 210 RGYCSNQLAAKALLDQ---KKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPL 266
YCS+ A+ L+Q ++D R + ++ C K L L +P R++KY L
Sbjct: 279 GEYCSHMEHAQNTLNQLLASREDFRQK--VEECTLKVQDGKFKLQDLLVVPMQRVLKYHL 336
Query: 267 LLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGE-------SECQYYIDKLEYLD 319
LLKE+L H+ E P+ Q L++A+ +Q + IN K + SE Q I+ L+
Sbjct: 337 LLKELLSHS-AERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKL 395
Query: 320 EKQRDPRIEASKVLLCHGELRSKS-----GHKLYIFLFQDILVLTRPVTRNERHSYQV 372
E+ P+I+ GEL+ +S Y+FLF +++ V + + +SY++
Sbjct: 396 EEFGRPKID--------GELKVRSIVNHTKQDRYLFLFDKVVI----VCKRKGYSYEL 441
>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 878
Score = 73.9 bits (180), Expect = 3e-13
Identities = 73/278 (26%), Positives = 131/278 (47%), Gaps = 34/278 (12%)
Query: 110 MKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLD 169
M++ T + +R + E+ E L+ K Y P L+L ++S ++ +F +L+
Sbjct: 188 MQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSP-LRL-VLSPADMAAVFINLE 245
Query: 170 SYIPLHEDLLTRIGEATKPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQ---K 226
I +H L I + G+ + + + + RL Y YCS+ A+ L+Q
Sbjct: 246 DLIKVHHSFLRAIDVSVMVGGST--LAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLAS 303
Query: 227 KQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLE 286
++D R + ++ C K L L +P R++KY LLLKE+L H+ E P+ Q L+
Sbjct: 304 REDFRQK--VEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHS-AERPERQQLK 360
Query: 287 DAILIIQGVLSDINLKKGE-------SECQYYIDKLEYLDEKQRDPRIEASKVLLCHGEL 339
+A+ +Q + IN K + SE Q I+ L+ E+ P+I+ GEL
Sbjct: 361 EALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKID--------GEL 412
Query: 340 RSKS-----GHKLYIFLFQDILVLTRPVTRNERHSYQV 372
+ +S Y+FLF +++ V + + +SY++
Sbjct: 413 KVRSIVNHTKQDRYLFLFDKVVI----VCKRKGYSYEL 446
>gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]
Length = 709
Score = 73.2 bits (178), Expect = 6e-13
Identities = 75/338 (22%), Positives = 144/338 (42%), Gaps = 24/338 (7%)
Query: 77 SPASAQKFSSRSTVPTPAKRRSSALWS---EMLDITMKESLTTREIRRQEAIYEMSRGEQ 133
SP QK + T+ + R + WS E++++ + + L+T E +RQEA++E+ E
Sbjct: 240 SPEGTQKVDA--TIVVKSYRPAQVTWSQLPEVVELGILDQLSTEERKRQEAMFEILTSEF 297
Query: 134 DLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVE 193
L + + + + +++ E H+F ++ + + + + K VE
Sbjct: 298 SYQHSLSILVEEFLQSKELRATVTQMEHHHLFSNILDVLGASQRFFEDLEQRHKAQVLVE 357
Query: 194 QIGHILVSWLPR-LNAYRGYCSNQLAAKALLDQK-KQDPRVQDFLQRCLESPFSRKLDLW 251
I IL + + Y YCSN++ + L + + ++ L+ P L +
Sbjct: 358 DISDILEEHAEKHFHPYIAYCSNEVYQQRTLQKLISSNAAFREALREIERRPACGGLPML 417
Query: 252 SFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINL---KKGESEC 308
SFL +P R+ + PLL+ + T + A+ I ++ N + E
Sbjct: 418 SFLILPMQRVTRLPLLMDTLCLKTQGHSERYKAASRALKAISKLVRQCNEGAHRMERMEQ 477
Query: 309 QYYIDKLEYLDEKQRDPRIEASKVLLCHGEL----------RSKSGHKLYIFLFQDILVL 358
Y + + + P I AS+ LL GEL + S Y+FLF D+LV+
Sbjct: 478 MYTLHTQLDFSKVKSLPLISASRWLLKRGELFLVEETGLFRKIASRPTCYLFLFNDVLVV 537
Query: 359 TRPVTRNERHSYQVYRQPIPVQELVLEDLQDGDVRMGG 396
T+ + E + Q Y Q + + +E ++ ++ + G
Sbjct: 538 TKKKS-EESYMVQDYAQ---MNHIQVEKIEPSELPLPG 571
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform
2 [Homo sapiens]
Length = 1562
Score = 72.8 bits (177), Expect = 8e-13
Identities = 52/183 (28%), Positives = 87/183 (47%), Gaps = 11/183 (6%)
Query: 102 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEEL 161
W + + LT REI RQE I E+ E + L++ ++ M K ++M EEL
Sbjct: 756 WQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREEL 815
Query: 162 THIFGDLDSYIPLHEDLLTRIGEATKPDGTVEQIGHILVS--------WLPRLNAYRGYC 213
+F +L I +H + + + +++I ++++ L ++ A +C
Sbjct: 816 ARLFPNLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQ--FC 873
Query: 214 SNQLAAKALLDQK-KQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEIL 272
S Q A L+ K +++ R Q F+Q P R+L L + RL KYPLLL+ I+
Sbjct: 874 SYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESII 933
Query: 273 KHT 275
KHT
Sbjct: 934 KHT 936
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform
1 [Homo sapiens]
Length = 1522
Score = 72.8 bits (177), Expect = 8e-13
Identities = 52/183 (28%), Positives = 87/183 (47%), Gaps = 11/183 (6%)
Query: 102 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEEL 161
W + + LT REI RQE I E+ E + L++ ++ M K ++M EEL
Sbjct: 716 WQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREEL 775
Query: 162 THIFGDLDSYIPLHEDLLTRIGEATKPDGTVEQIGHILVS--------WLPRLNAYRGYC 213
+F +L I +H + + + +++I ++++ L ++ A +C
Sbjct: 776 ARLFPNLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQ--FC 833
Query: 214 SNQLAAKALLDQK-KQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEIL 272
S Q A L+ K +++ R Q F+Q P R+L L + RL KYPLLL+ I+
Sbjct: 834 SYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESII 893
Query: 273 KHT 275
KHT
Sbjct: 894 KHT 896
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
[Homo sapiens]
Length = 690
Score = 72.8 bits (177), Expect = 8e-13
Identities = 82/340 (24%), Positives = 147/340 (43%), Gaps = 31/340 (9%)
Query: 112 ESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIM-SEEELTHIFGDLDS 170
E+ ++++ R I E+ E+D I+ L+ + Y K + M SEE+L IFG+++
Sbjct: 276 EAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIED 335
Query: 171 YIPLHEDLLTRIGEATKPDGT-VEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQD 229
+ + + + + + ++G + Y YC+N A L + +
Sbjct: 336 IYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKL 395
Query: 230 PRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAI 289
+ F + C + L FL P ++ KYPL L E+LK+T +H D + +E A+
Sbjct: 396 SKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAAL 455
Query: 290 LIIQGVLSDINLKKGESECQYYIDKL----EYLDEKQRDPRIEASKVLLCHGEL------ 339
++ V IN +K E IDK+ +++ + + + S L+ GEL
Sbjct: 456 HAMKNVAQLINERKRRLE---NIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQP 512
Query: 340 RSKSGHKLYIFLFQDILVLTRPVTRNERHSYQVYRQPIPVQELVLEDLQDG-DVRMGGSF 398
++KS +++ FLF L+ + R Y+ + + L + DL+DG D + S
Sbjct: 513 QAKSQQRMF-FLFDHQLIYCKKDLL--RRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVSI 569
Query: 399 RGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQQW 438
+ AF R H + SH L KQ+W
Sbjct: 570 KNAF------------RLHRGATGDSHLLCTRKPEQKQRW 597
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,698,774
Number of Sequences: 37866
Number of extensions: 926207
Number of successful extensions: 3127
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 94
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 2920
Number of HSP's gapped (non-prelim): 156
length of query: 542
length of database: 18,247,518
effective HSP length: 107
effective length of query: 435
effective length of database: 14,195,856
effective search space: 6175197360
effective search space used: 6175197360
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.