Search of human proteins with 195539395

Search of human proteins with 195539395

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]
         (403 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]           799   0.0  
gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]            341   8e-94
gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]             323   1e-88
gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]            306   2e-83
gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit ...   306   3e-83
gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]   306   3e-83
gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo sapi...   298   4e-81
gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]            283   2e-76
gi|169167838 PREDICTED: similar to hCG2002932 [Homo sapiens]          241   6e-64
gi|239748566 PREDICTED: similar to hCG2002932 [Homo sapiens]          241   6e-64
gi|239742549 PREDICTED: hypothetical protein LOC345645 [Homo sap...   241   6e-64
gi|157671927 spermatogenesis associated 5 [Homo sapiens]              204   9e-53
gi|6005942 valosin-containing protein [Homo sapiens]                  202   4e-52
gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]            194   1e-49
gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]       184   1e-46
gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens]              182   5e-46
gi|4505725 peroxin1 [Homo sapiens]                                    179   3e-45
gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]                 178   9e-45
gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]                 178   9e-45
gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]     174   1e-43
gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]   171   8e-43
gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]                      167   2e-41
gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]                       167   2e-41
gi|5901990 katanin p60 subunit A 1 [Homo sapiens]                     163   3e-40
gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]     160   1e-39
gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]               159   4e-39
gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]               159   4e-39
gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]           158   9e-39
gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]              155   8e-38
gi|31742536 fidgetin-like 1 [Homo sapiens]                            146   3e-35

>gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]
          Length = 403

 Score =  799 bits (2064), Expect = 0.0
 Identities = 403/403 (100%), Positives = 403/403 (100%)

Query: 1   MAIPGIPYERRLLIMADPRDKALQDYRKKLLEHKEIDGRLKELREQLKELTKQYEKSEND 60
           MAIPGIPYERRLLIMADPRDKALQDYRKKLLEHKEIDGRLKELREQLKELTKQYEKSEND
Sbjct: 1   MAIPGIPYERRLLIMADPRDKALQDYRKKLLEHKEIDGRLKELREQLKELTKQYEKSEND 60

Query: 61  LKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDMTTLT 120
           LKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDMTTLT
Sbjct: 61  LKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDMTTLT 120

Query: 121 IMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIP 180
           IMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIP
Sbjct: 121 IMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIP 180

Query: 181 PKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQ 240
           PKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQ
Sbjct: 181 PKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQ 240

Query: 241 PCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLD 300
           PCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLD
Sbjct: 241 PCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLD 300

Query: 301 PALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNV 360
           PALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNV
Sbjct: 301 PALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNV 360

Query: 361 CTEAGMFAIRADHDFVVQEDFMKAVRKVADSKKLESKLDYKPV 403
           CTEAGMFAIRADHDFVVQEDFMKAVRKVADSKKLESKLDYKPV
Sbjct: 361 CTEAGMFAIRADHDFVVQEDFMKAVRKVADSKKLESKLDYKPV 403


>gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]
          Length = 406

 Score =  341 bits (874), Expect = 8e-94
 Identities = 179/356 (50%), Positives = 240/356 (67%), Gaps = 2/356 (0%)

Query: 40  LKELREQLKELTKQYEKSENDLKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRR 99
           L+ L+ Q  EL  +      +L+ LQ  G  VGEV++ + ++K +VK     ++VV   +
Sbjct: 42  LRRLQAQRNELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDK 101

Query: 100 QLDKSKLKPGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIREL 159
            +D + + P  RVAL   + T+ + LP +VDPLV  M  E   + +Y  IGGL +QI+E+
Sbjct: 102 NIDINDVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEI 161

Query: 160 REVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVD 219
           +EVIELP+ +PELF+ +GI  PKG LLYGPPGTGKTLLARAVA   DC F++V  S +V 
Sbjct: 162 KEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQ 221

Query: 220 KYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMD 279
           K+IGE AR++RE+F  AR+H P IIFMDEID+IG  R   G+  D E+QRT++ELLNQ+D
Sbjct: 222 KFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLD 281

Query: 280 GFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGE 339
           GF+    +K+IMATNR D LD ALLRPGR+DRKI    PNE+ARLDILKIH+  +     
Sbjct: 282 GFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRG 341

Query: 340 IDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQEDFMKAVRKV--ADSKK 393
           I+   I +L  G +GA+++ VCTEAGM+A+R     V QEDF  AV KV   DS+K
Sbjct: 342 INLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEK 397


>gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]
          Length = 433

 Score =  323 bits (829), Expect = 1e-88
 Identities = 167/374 (44%), Positives = 238/374 (63%), Gaps = 16/374 (4%)

Query: 34  KEIDGRLKELREQLKELTKQYEKSEN-----------DLKALQS-----VGQIVGEVLKQ 77
           K+++  +++L +++ ELT   E               D + LQS     V +    +   
Sbjct: 46  KQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINAD 105

Query: 78  LTEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDMTTLTIMRYLPREVDPLVYNMS 137
             + K+I+      ++VV    Q+  + ++ G RV +D     I   LP ++DP V  M 
Sbjct: 106 SEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQ 165

Query: 138 HEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLL 197
            E+  +V+YS++GG  EQI +LREV+E PL +PE F  +GI PPKG LL+GPPGTGKTL 
Sbjct: 166 VEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLC 225

Query: 198 ARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRF 257
           ARAVA++ D  F++V+ S +V KY+GE AR++RE+F  AR  + C+IF DEIDAIGG RF
Sbjct: 226 ARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARF 285

Query: 258 SEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDL 317
            +G   D E+QRT++EL+NQ+DGFD    +K++MATNRPDTLDPAL+RPGRLDRKI   L
Sbjct: 286 DDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSL 345

Query: 318 PNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVV 377
           P+ + R  I KIHA  ++   +I +E + +L     GA++R+VCTEAGMFAIRA      
Sbjct: 346 PDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIAT 405

Query: 378 QEDFMKAVRKVADS 391
           ++DF++AV KV  S
Sbjct: 406 EKDFLEAVNKVIKS 419


>gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]
          Length = 440

 Score =  306 bits (784), Expect = 2e-83
 Identities = 152/350 (43%), Positives = 227/350 (64%)

Query: 44  REQLKELTKQYEKSENDLKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDK 103
           +EQ+K L ++ E+  + +  L+     VG + + + +   IV  + G  + V     +DK
Sbjct: 82  QEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDK 141

Query: 104 SKLKPGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVI 163
             L+PG  V L+     ++  L  + DPLV  M  E     +Y++IGGL  QI+E++E +
Sbjct: 142 DLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESV 201

Query: 164 ELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIG 223
           ELPLT+PE ++ +GI PPKG +LYGPPGTGKTLLA+AVA+Q    FL+VV S ++ KY+G
Sbjct: 202 ELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLG 261

Query: 224 ESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDT 283
           +  +L+RE+F  A +H P I+F+DEIDAIG +R+   +  +REIQRT++ELLNQ+DGFD+
Sbjct: 262 DGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDS 321

Query: 284 LHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYE 343
              VK+IMATNR +TLDPAL+RPGR+DRKI   LP+E+ +  I +IH   +T   ++  +
Sbjct: 322 RGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLD 381

Query: 344 AIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQEDFMKAVRKVADSKK 393
            ++   D  +GAD++ +CTEAG+ A+R     V  EDF K+   V   K+
Sbjct: 382 DLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQ 431


>gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit 4
           [Homo sapiens]
          Length = 414

 Score =  306 bits (783), Expect = 3e-83
 Identities = 158/382 (41%), Positives = 241/382 (63%), Gaps = 4/382 (1%)

Query: 18  PRDKALQD----YRKKLLEHKEIDGRLKELREQLKELTKQYEKSENDLKALQSVGQIVGE 73
           P  + L+D    Y+K   E + ++ + + ++++ K L K++  ++ ++K +QS+  ++G+
Sbjct: 28  PEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQ 87

Query: 74  VLKQLTEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDMTTLTIMRYLPREVDPLV 133
            L+ + +   IV +T G  Y V     +D+  LKP   VAL   +  ++  LP E D  +
Sbjct: 88  FLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSI 147

Query: 134 YNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTG 193
             ++ +   +V Y++IGG+  Q +E+RE +ELPLT+ EL++++GI PP+G L+YGPPG G
Sbjct: 148 MMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCG 207

Query: 194 KTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIG 253
           KT+LA+AVA      F++VV S  V KY+GE  R++R++F  A+++ P IIF+DEIDAI 
Sbjct: 208 KTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIA 267

Query: 254 GRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKI 313
            +RF   T ADRE+QR L+ELLNQMDGFD    VK+IMATNR DTLDPALLRPGRLDRKI
Sbjct: 268 TKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKI 327

Query: 314 HIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADH 373
              LP+ + +  I       +    E+D E  V   D  +GAD+ ++C E+GM A+R + 
Sbjct: 328 EFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENR 387

Query: 374 DFVVQEDFMKAVRKVADSKKLE 395
             V+ +DF KA + V    + E
Sbjct: 388 YIVLAKDFEKAYKTVIKKDEQE 409


>gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]
          Length = 418

 Score =  306 bits (783), Expect = 3e-83
 Identities = 158/382 (41%), Positives = 241/382 (63%), Gaps = 4/382 (1%)

Query: 18  PRDKALQD----YRKKLLEHKEIDGRLKELREQLKELTKQYEKSENDLKALQSVGQIVGE 73
           P  + L+D    Y+K   E + ++ + + ++++ K L K++  ++ ++K +QS+  ++G+
Sbjct: 32  PEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQ 91

Query: 74  VLKQLTEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDMTTLTIMRYLPREVDPLV 133
            L+ + +   IV +T G  Y V     +D+  LKP   VAL   +  ++  LP E D  +
Sbjct: 92  FLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSI 151

Query: 134 YNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTG 193
             ++ +   +V Y++IGG+  Q +E+RE +ELPLT+ EL++++GI PP+G L+YGPPG G
Sbjct: 152 MMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCG 211

Query: 194 KTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIG 253
           KT+LA+AVA      F++VV S  V KY+GE  R++R++F  A+++ P IIF+DEIDAI 
Sbjct: 212 KTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIA 271

Query: 254 GRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKI 313
            +RF   T ADRE+QR L+ELLNQMDGFD    VK+IMATNR DTLDPALLRPGRLDRKI
Sbjct: 272 TKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKI 331

Query: 314 HIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADH 373
              LP+ + +  I       +    E+D E  V   D  +GAD+ ++C E+GM A+R + 
Sbjct: 332 EFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENR 391

Query: 374 DFVVQEDFMKAVRKVADSKKLE 395
             V+ +DF KA + V    + E
Sbjct: 392 YIVLAKDFEKAYKTVIKKDEQE 413


>gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo
           sapiens]
          Length = 387

 Score =  298 bits (764), Expect = 4e-81
 Identities = 153/356 (42%), Positives = 225/356 (63%)

Query: 40  LKELREQLKELTKQYEKSENDLKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRR 99
           L  L  + ++L   Y + + ++K +QS+  ++G+ L+ + +   IV +T G  Y V    
Sbjct: 27  LSFLGPEPEDLEDLYSRYKEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILS 86

Query: 100 QLDKSKLKPGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIREL 159
            +D+  LKP   VAL   +  ++  LP E D  +  ++ +   +V Y++IGG+  Q +E+
Sbjct: 87  TIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEV 146

Query: 160 REVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVD 219
           RE +ELPLT+ EL++++GI PP+G L+YGPPG GKT+LA+AVA      F++VV S  V 
Sbjct: 147 REAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQ 206

Query: 220 KYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMD 279
           KY+GE  R++R++F  A+++ P IIF+DEIDAI  +RF   T ADRE+QR L+ELLNQMD
Sbjct: 207 KYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMD 266

Query: 280 GFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGE 339
           GFD    VK+IMATNR DTLDPALLRPGRLDRKI   LP+ + +  I       +    E
Sbjct: 267 GFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEE 326

Query: 340 IDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQEDFMKAVRKVADSKKLE 395
           +D E  V   D  +GAD+ ++C E+GM A+R +   V+ +DF KA + V    + E
Sbjct: 327 VDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQE 382


>gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]
          Length = 439

 Score =  283 bits (724), Expect = 2e-76
 Identities = 143/310 (46%), Positives = 201/310 (64%)

Query: 84  IVKATNGPRYVVGCRRQLDKSKLKPGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGN 143
           ++K +    Y +     +D  KLKPG  V ++  +  I+  LP E D  V  M  ++   
Sbjct: 123 VIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPT 182

Query: 144 VSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVAS 203
             YS+IGGL +QI+EL E I LP+ + E F+ +GI PPKG L+YGPPGTGKTLLARA A+
Sbjct: 183 EQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAA 242

Query: 204 QLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSA 263
           Q    FLK+    +V  +IG+ A+L+R+ F  A++  P IIF+DE+DAIG +RF    + 
Sbjct: 243 QTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAG 302

Query: 264 DREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQAR 323
           DRE+QRT++ELLNQ+DGF    +VK+I ATNR D LDPALLR GRLDRKI   +PNE+AR
Sbjct: 303 DREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEAR 362

Query: 324 LDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQEDFMK 383
             I++IH+  +    +++YE + + +D FNGA  + VC EAGM A+R     +  ED+M+
Sbjct: 363 ARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYME 422

Query: 384 AVRKVADSKK 393
            + +V   KK
Sbjct: 423 GILEVQAKKK 432


>gi|169167838 PREDICTED: similar to hCG2002932 [Homo sapiens]
          Length = 415

 Score =  241 bits (616), Expect = 6e-64
 Identities = 126/351 (35%), Positives = 202/351 (57%), Gaps = 16/351 (4%)

Query: 44  REQLKELTKQYEKSENDLKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDK 103
           +EQ+K L ++ E+  + +  L+     VG + + + +   IV  + G  +       ++K
Sbjct: 69  QEQIKLLEEKQEEGRSKVDDLRGTPMSVGNLEEIIDDNHAIVSTSVGSEHYDSIISFVEK 128

Query: 104 SKLKPGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVI 163
             L+PG  + L      ++  L  +  PLV  M  E     +Y   GGL  QI+E++E +
Sbjct: 129 DLLEPGCSILLRHKVHAVIGVLMDDTGPLVTMMKVEKAPQETYVNTGGLDNQIQEIKESM 188

Query: 164 ELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIG 223
           ELPL +PE ++ +G  PPKG +L GPPGT                FL+VV S ++ KY+G
Sbjct: 189 ELPLPHPEYYEEMGTKPPKGVILCGPPGTA--------------TFLRVVGSELIQKYLG 234

Query: 224 ESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMEL--LNQMDGF 281
           +  +L+R++F  A +H P I+F DEI+AIG +R+   +  +REIQ+T++EL  LNQ+ GF
Sbjct: 235 DGPKLVRQVFQVAEEHAPSIMFTDEIEAIGTKRYDSNSGGEREIQQTMLELELLNQLGGF 294

Query: 282 DTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEID 341
           D+   VK+IMAT + +TLDP L+RPGR+D+KI   LP+E+ +  I +IH   +T   ++ 
Sbjct: 295 DSREDVKVIMATKQVETLDPVLIRPGRIDKKIEFHLPDEKTKKHIFQIHTSRMTLANDVT 354

Query: 342 YEAIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQEDFMKAVRKVADSK 392
            + ++   D F+GAD++ +CTEAG+ A+R        EDF K++  V   K
Sbjct: 355 LDDLIMAKDDFSGADIKAICTEAGLMALREHRMKATNEDFKKSIESVLYKK 405


>gi|239748566 PREDICTED: similar to hCG2002932 [Homo sapiens]
          Length = 415

 Score =  241 bits (616), Expect = 6e-64
 Identities = 126/351 (35%), Positives = 202/351 (57%), Gaps = 16/351 (4%)

Query: 44  REQLKELTKQYEKSENDLKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDK 103
           +EQ+K L ++ E+  + +  L+     VG + + + +   IV  + G  +       ++K
Sbjct: 69  QEQIKLLEEKQEEGRSKVDDLRGTPMSVGNLEEIIDDNHAIVSTSVGSEHYDSIISFVEK 128

Query: 104 SKLKPGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVI 163
             L+PG  + L      ++  L  +  PLV  M  E     +Y   GGL  QI+E++E +
Sbjct: 129 DLLEPGCSILLRHKVHAVIGVLMDDTGPLVTMMKVEKAPQETYVNTGGLDNQIQEIKESM 188

Query: 164 ELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIG 223
           ELPL +PE ++ +G  PPKG +L GPPGT                FL+VV S ++ KY+G
Sbjct: 189 ELPLPHPEYYEEMGTKPPKGVILCGPPGTA--------------TFLRVVGSELIQKYLG 234

Query: 224 ESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMEL--LNQMDGF 281
           +  +L+R++F  A +H P I+F DEI+AIG +R+   +  +REIQ+T++EL  LNQ+ GF
Sbjct: 235 DGPKLVRQVFQVAEEHAPSIMFTDEIEAIGTKRYDSNSGGEREIQQTMLELELLNQLGGF 294

Query: 282 DTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEID 341
           D+   VK+IMAT + +TLDP L+RPGR+D+KI   LP+E+ +  I +IH   +T   ++ 
Sbjct: 295 DSREDVKVIMATKQVETLDPVLIRPGRIDKKIEFHLPDEKTKKHIFQIHTSRMTLANDVT 354

Query: 342 YEAIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQEDFMKAVRKVADSK 392
            + ++   D F+GAD++ +CTEAG+ A+R        EDF K++  V   K
Sbjct: 355 LDDLIMAKDDFSGADIKAICTEAGLMALREHRMKATNEDFKKSIESVLYKK 405


>gi|239742549 PREDICTED: hypothetical protein LOC345645 [Homo
           sapiens]
          Length = 415

 Score =  241 bits (616), Expect = 6e-64
 Identities = 126/351 (35%), Positives = 202/351 (57%), Gaps = 16/351 (4%)

Query: 44  REQLKELTKQYEKSENDLKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDK 103
           +EQ+K L ++ E+  + +  L+     VG + + + +   IV  + G  +       ++K
Sbjct: 69  QEQIKLLEEKQEEGRSKVDDLRGTPMSVGNLEEIIDDNHAIVSTSVGSEHYDSIISFVEK 128

Query: 104 SKLKPGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVI 163
             L+PG  + L      ++  L  +  PLV  M  E     +Y   GGL  QI+E++E +
Sbjct: 129 DLLEPGCSILLRHKVHAVIGVLMDDTGPLVTMMKVEKAPQETYVNTGGLDNQIQEIKESM 188

Query: 164 ELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIG 223
           ELPL +PE ++ +G  PPKG +L GPPGT                FL+VV S ++ KY+G
Sbjct: 189 ELPLPHPEYYEEMGTKPPKGVILCGPPGTA--------------TFLRVVGSELIQKYLG 234

Query: 224 ESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMEL--LNQMDGF 281
           +  +L+R++F  A +H P I+F DEI+AIG +R+   +  +REIQ+T++EL  LNQ+ GF
Sbjct: 235 DGPKLVRQVFQVAEEHAPSIMFTDEIEAIGTKRYDSNSGGEREIQQTMLELELLNQLGGF 294

Query: 282 DTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEID 341
           D+   VK+IMAT + +TLDP L+RPGR+D+KI   LP+E+ +  I +IH   +T   ++ 
Sbjct: 295 DSREDVKVIMATKQVETLDPVLIRPGRIDKKIEFHLPDEKTKKHIFQIHTSRMTLANDVT 354

Query: 342 YEAIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQEDFMKAVRKVADSK 392
            + ++   D F+GAD++ +CTEAG+ A+R        EDF K++  V   K
Sbjct: 355 LDDLIMAKDDFSGADIKAICTEAGLMALREHRMKATNEDFKKSIESVLYKK 405


>gi|157671927 spermatogenesis associated 5 [Homo sapiens]
          Length = 893

 Score =  204 bits (520), Expect = 9e-53
 Identities = 128/370 (34%), Positives = 199/370 (53%), Gaps = 22/370 (5%)

Query: 36  IDGRLKELREQLKELTKQYEKSENDLKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYV- 94
           +D  L+      KE+      +++ L  LQ   +++  V   LTE + +  A +   YV 
Sbjct: 505 LDAALRRPGRFDKEIEIGVPNAQDRLDILQ---KLLRRVPHLLTEAELLQLANSAHGYVG 561

Query: 95  ------------VGCRRQLDKSKLKPGTRVALDMTTLTIMRYLP--REVDPLVYNMSHED 140
                          RR L K    P  +VA  +  +T+  +L    ++ P        D
Sbjct: 562 ADLKVLCNEAGLCALRRILKKQPNLPDVKVA-GLVKITLKDFLQAMNDIRPSAMREIAID 620

Query: 141 PGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARA 200
             NVS+S+IGGL     +L + +E PL +PE F R+GI PPKG LLYGPPG  KT++A+A
Sbjct: 621 VPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKA 680

Query: 201 VASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEG 260
           +A++   NFL +    +++KY+GES R +RE F  AR   P IIF DE+DA+   R S  
Sbjct: 681 LANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVERGS-S 739

Query: 261 TSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNE 320
             A     R L +LL +MDG + L  V ++ ATNRPD +D AL+RPGR+DR I++ LP+ 
Sbjct: 740 LGAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDKALMRPGRIDRIIYVPLPDA 799

Query: 321 QARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRAD--HDFVVQ 378
             R +I K+    +    E+D + ++  +D ++GA++  VC EA + A+  D   + +++
Sbjct: 800 ATRREIFKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAVCREAALLALEEDIQANLIMK 859

Query: 379 EDFMKAVRKV 388
             F +A+  V
Sbjct: 860 RHFTQALSTV 869



 Score =  175 bits (443), Expect = 7e-44
 Identities = 102/271 (37%), Positives = 156/271 (57%), Gaps = 15/271 (5%)

Query: 144 VSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVAS 203
           V+Y  IGGLS Q++ +RE+IELPL  PELF+  GI  P+G LLYGPPGTGKT++ARAVA+
Sbjct: 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVAN 409

Query: 204 QLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSA 263
           ++      +    I+ K+ GE+   +R++F  A    P IIF+DE+DA+  +R       
Sbjct: 410 EVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEV 469

Query: 264 DREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQAR 323
           ++ +  +L+ L++ +    +  +V ++ ATNRP  LD AL RPGR D++I I +PN Q R
Sbjct: 470 EKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDR 529

Query: 324 LDIL-KIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIR------------ 370
           LDIL K+         E +   +   + G+ GADL+ +C EAG+ A+R            
Sbjct: 530 LDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRILKKQPNLPDV 589

Query: 371 --ADHDFVVQEDFMKAVRKVADSKKLESKLD 399
             A    +  +DF++A+  +  S   E  +D
Sbjct: 590 KVAGLVKITLKDFLQAMNDIRPSAMREIAID 620


>gi|6005942 valosin-containing protein [Homo sapiens]
          Length = 806

 Score =  202 bits (514), Expect = 4e-52
 Identities = 111/283 (39%), Positives = 174/283 (61%), Gaps = 16/283 (5%)

Query: 98  RRQLDKSKLKPGTRVALDMTTLTI----MRYLPREVDPLVYNMSHEDPGNVSYSEIGGLS 153
           R+++D   L+  T  A  M +L +     R+   + +P     +  +   V++ +IGGL 
Sbjct: 424 RKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLE 483

Query: 154 EQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVV 213
           +  REL+E+++ P+ +P+ F + G+ P KG L YGPPG GKTLLA+A+A++   NF+ + 
Sbjct: 484 DVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIK 543

Query: 214 SSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAI----GGRRFSEGTSADREIQR 269
              ++  + GES   +RE+F+ AR   PC++F DE+D+I    GG     G +ADR I  
Sbjct: 544 GPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVIN- 602

Query: 270 TLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILK- 328
              ++L +MDG  T   V +I ATNRPD +DPA+LRPGRLD+ I+I LP+E++R+ ILK 
Sbjct: 603 ---QILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKA 659

Query: 329 -IHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIR 370
            +   P+ K  ++D E + K+++GF+GADL  +C  A   AIR
Sbjct: 660 NLRKSPVAK--DVDLEFLAKMTNGFSGADLTEICQRACKLAIR 700



 Score =  196 bits (497), Expect = 4e-50
 Identities = 105/253 (41%), Positives = 155/253 (61%), Gaps = 3/253 (1%)

Query: 128 EVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLY 187
           E +P+      E    V Y +IGG  +Q+ +++E++ELPL +P LF+ +G+ PP+G LLY
Sbjct: 185 EGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLY 244

Query: 188 GPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMD 247
           GPPGTGKTL+ARAVA++    F  +    I+ K  GES   +R+ F  A  + P IIF+D
Sbjct: 245 GPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFID 304

Query: 248 EIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPG 307
           E+DAI  +R  E T  + E +R + +LL  MDG      V ++ ATNRP+++DPAL R G
Sbjct: 305 ELDAIAPKR--EKTHGEVE-RRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFG 361

Query: 308 RLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMF 367
           R DR++ I +P+   RL+IL+IH   +    ++D E +   + G  GADL  +C+EA + 
Sbjct: 362 RFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQ 421

Query: 368 AIRADHDFVVQED 380
           AIR   D +  ED
Sbjct: 422 AIRKKMDLIDLED 434


>gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]
          Length = 797

 Score =  194 bits (493), Expect = 1e-49
 Identities = 101/254 (39%), Positives = 153/254 (60%), Gaps = 5/254 (1%)

Query: 139 EDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLA 198
           +D  +V + ++ G  E   E+ E +   L NP+ +Q +G   PKG +L GPPGTGKTLLA
Sbjct: 300 KDEIDVKFKDVAGCEEAKLEIMEFVNF-LKNPKQYQDLGAKIPKGAILTGPPGTGKTLLA 358

Query: 199 RAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFS 258
           +A A + +  F+ V  S  ++ ++G     +R++F  AR + PCI+F+DEIDA+G +R  
Sbjct: 359 KATAGEANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGR 418

Query: 259 EGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLP 318
                  E + TL +LL +MDGF+T   V ++  TNRPD LDPALLRPGR DR+I I  P
Sbjct: 419 GNFGGQSEQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPP 478

Query: 319 NEQARLDILKIHAGPITKHGEIDYEAIVK----LSDGFNGADLRNVCTEAGMFAIRADHD 374
           + + R  I K+H  P+     ++ + + +    L+ GF+GAD+ NVC EA + A R   D
Sbjct: 479 DIKGRASIFKVHLRPLKLDSTLEKDKLARKLASLTPGFSGADVANVCNEAALIAARHLSD 538

Query: 375 FVVQEDFMKAVRKV 388
            + Q+ F +A+ +V
Sbjct: 539 SINQKHFEQAIERV 552


>gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]
          Length = 753

 Score =  184 bits (467), Expect = 1e-46
 Identities = 108/270 (40%), Positives = 158/270 (58%), Gaps = 23/270 (8%)

Query: 144 VSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVAS 203
           V + EIGGL +   +L++ IE PL  P  F R+G+  PKG LLYGPPG  KT L RA+A+
Sbjct: 461 VDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTLVRALAT 520

Query: 204 QLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSA 263
              C+F+ V  + +   ++G+S +++ ++F  AR   P I+F+DEID+I G R +  T  
Sbjct: 521 SCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKTGC 580

Query: 264 DREIQRTLMELLNQMD--GFDTLHR-----------------VKMIMATNRPDTLDPALL 304
           D + +R L  LLN++D  G  T+ R                 V +I ATNRPD LD ALL
Sbjct: 581 DVQ-ERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALL 639

Query: 305 RPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEA 364
           RPGRLD+ I+I  P+ + RL ILK+    +    ++  E +   +  F+GADLRN+CTEA
Sbjct: 640 RPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLENLAAETCFFSGADLRNLCTEA 699

Query: 365 GMFAIR---ADHDFVVQEDFMKAVRKVADS 391
            + A++    D   V QE F+K+++ V  S
Sbjct: 700 ALLALQENGLDATTVKQEHFLKSLKTVKPS 729



 Score =  154 bits (390), Expect = 1e-37
 Identities = 92/265 (34%), Positives = 144/265 (54%), Gaps = 15/265 (5%)

Query: 149 IGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCN 208
           +GGLSE    LRE++ LPL  P     +G+  P+G LL GPPG GKT L RAVA +    
Sbjct: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAE 261

Query: 209 FLKVVSSSIVDKYIGESARLIREMFNYARD---HQPCIIFMDEIDAIGGRRFSEGTSADR 265
            L V + ++     GE+   +R +F  AR+     P ++F+DE+DA+  +R S    +  
Sbjct: 262 LLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRGSRAPES-- 319

Query: 266 EIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLD 325
              R + ++L  +DG      V ++ ATNRPD LDPAL RPGR DR++ I  P  + R +
Sbjct: 320 ---RVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKE 376

Query: 326 ILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAI-----RADHDFVVQED 380
           IL++    +     +D   + +++ G+ GADL  +C EA M A+       D+  + + D
Sbjct: 377 ILQVITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHALLHSEKNQDNPVIDEID 436

Query: 381 FMKAVRKVADS--KKLESKLDYKPV 403
           F++A + +  S  + +   +D KPV
Sbjct: 437 FLEAFKNIQPSSFRSVIGLMDIKPV 461


>gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens]
          Length = 795

 Score =  182 bits (462), Expect = 5e-46
 Identities = 107/267 (40%), Positives = 159/267 (59%), Gaps = 8/267 (2%)

Query: 144 VSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVAS 203
           VS+ ++ G+ E   E+RE ++  L +PE F ++G   PKG LL GPPG GKTLLA+AVA+
Sbjct: 306 VSFKDVAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVAT 364

Query: 204 QLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTS- 262
           +    FL +     V+   G  A  +R +F  AR   PCI+++DEIDA+G +R +  +  
Sbjct: 365 EAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGF 424

Query: 263 ADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQA 322
           ++ E ++TL +LL +MDG  T   V ++ +TNR D LD AL+RPGRLDR + IDLP  Q 
Sbjct: 425 SNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQE 484

Query: 323 RLDILKIH--AGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQED 380
           R +I + H  +  +T+      + + +L+ GF+GAD+ N+C EA + A R  H  V   +
Sbjct: 485 RREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSVHTLN 544

Query: 381 FMKAVRKV----ADSKKLESKLDYKPV 403
           F  AV +V    A   K+ SK + K V
Sbjct: 545 FEYAVERVLAGTAKKSKILSKEEQKVV 571


>gi|4505725 peroxin1 [Homo sapiens]
          Length = 1283

 Score =  179 bits (455), Expect = 3e-45
 Identities = 98/266 (36%), Positives = 157/266 (59%), Gaps = 3/266 (1%)

Query: 104  SKLKPGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVI 163
            S+    TR  L +TTL   + L   +   + +++   P ++ + +IGGL E  + L + I
Sbjct: 797  SRQSISTREKLVLTTLDFQKALRGFLPASLRSVNLHKPRDLGWDKIGGLHEVRQILMDTI 856

Query: 164  ELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIG 223
            +LP   PELF  + I    G LLYGPPGTGKTLLA  +A +   NF+ V    ++ KYIG
Sbjct: 857  QLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRMNFISVKGPELLSKYIG 916

Query: 224  ESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDT 283
             S + +R++F  A+  +PCI+F DE ++I  RR  + T       R + +LL Q+DG + 
Sbjct: 917  ASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGV---TDRVVNQLLTQLDGVEG 973

Query: 284  LHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYE 343
            L  V ++ AT+RPD +DPALLRPGRLD+ ++   P++ +RL+IL + +  +    ++D +
Sbjct: 974  LQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILNVLSDSLPLADDVDLQ 1033

Query: 344  AIVKLSDGFNGADLRNVCTEAGMFAI 369
             +  ++D F GADL+ +   A + A+
Sbjct: 1034 HVASVTDSFTGADLKALLYNAQLEAL 1059



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 67/306 (21%), Positives = 126/306 (41%), Gaps = 42/306 (13%)

Query: 114 LDMTTLTIMRYLPREVDPLVYNMSHEDPGNV----SYSEIGGLSEQ-IRELREVIELPLT 168
           L  TT+ ++      +DP+V   + E+   +      S +GG++   +  L  +    L 
Sbjct: 523 LQKTTIQVL------LDPMVKEENSEEIDFILPFLKLSSLGGVNSLGVSSLEHITHSLLG 576

Query: 169 NP---ELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQ----LDCNFLKVVSSSIVDKY 221
            P   +L   V  +     LL G  G+GK+ LA+A+  +    LD +  +V   ++  K 
Sbjct: 577 RPLSRQLMSLVAGLRNGALLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKR 636

Query: 222 IGESARLIREMFNYARDHQPCIIFMDEIDAIGG------RRFSEGTSADREIQRTLMELL 275
           +    + +   F+ A   QP ++ +D++D I G         S      + +   L +++
Sbjct: 637 LENIQKTLEVAFSEAVWMQPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMI 696

Query: 276 NQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRL---DRKIHIDLPNEQARLDIL----- 327
            +     +L  V +I  +    +L P L+    +       HI  PN++ R +IL     
Sbjct: 697 KEFISMGSL--VALIATSQSQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIK 754

Query: 328 -KIHAGPITKHGEIDYEAIVKLSDGFNGADL-----RNVCTEAGMFAIRADHDFVVQE-D 380
            K+    I K  ++D + + K + GF   D      R + +     +I      V+   D
Sbjct: 755 NKLDC-DINKFTDLDLQHVAKETGGFVARDFTVLVDRAIHSRLSRQSISTREKLVLTTLD 813

Query: 381 FMKAVR 386
           F KA+R
Sbjct: 814 FQKALR 819


>gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]
          Length = 750

 Score =  178 bits (451), Expect = 9e-45
 Identities = 99/239 (41%), Positives = 147/239 (61%), Gaps = 16/239 (6%)

Query: 143 NVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVA 202
           NV++++IG L +   EL   I  P+ NP+ F+ +G++ P G LL GPPG GKTLLA+AVA
Sbjct: 471 NVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVA 530

Query: 203 SQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTS 262
           ++   NF+ V    +++ Y+GES R +R++F  A++  PC+IF DE+DA+  RR    T 
Sbjct: 531 NESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETG 590

Query: 263 ADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQA 322
           A     R + +LL +MDG +   +V ++ ATNRPD +DPA+LRPGRLD+ + + LP    
Sbjct: 591 AS---VRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPAD 647

Query: 323 RLDILKIHAGPITKHG-------EIDYEAIV--KLSDGFNGADLRNVCTEAGMFAIRAD 372
           RL ILK     ITK+G       +++ EAI      D + GADL  +  EA + A+R +
Sbjct: 648 RLAILK----TITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQE 702



 Score =  174 bits (441), Expect = 1e-43
 Identities = 92/227 (40%), Positives = 140/227 (61%), Gaps = 1/227 (0%)

Query: 143 NVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVA 202
           NV + ++GG    ++E+ +++ + + +PE++  +G++PP+G LL+GPPG GKTLLA A+A
Sbjct: 155 NVKFEDVGGNDMTLKEVCKML-IHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIA 213

Query: 203 SQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTS 262
            +LD   LKV +  IV    GES + +RE+F  A  + PCIIF+DEIDAI  +R      
Sbjct: 214 GELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKD 273

Query: 263 ADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQA 322
            +R I   L+  ++ ++      RV +I ATNRPD+LDPAL R GR DR+I + +P+E +
Sbjct: 274 MERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEAS 333

Query: 323 RLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAI 369
           R  IL+     +      D+  +  L+ GF GADL  +C EA M A+
Sbjct: 334 RERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAV 380


>gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]
          Length = 856

 Score =  178 bits (451), Expect = 9e-45
 Identities = 99/239 (41%), Positives = 147/239 (61%), Gaps = 16/239 (6%)

Query: 143 NVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVA 202
           NV++++IG L +   EL   I  P+ NP+ F+ +G++ P G LL GPPG GKTLLA+AVA
Sbjct: 577 NVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVA 636

Query: 203 SQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTS 262
           ++   NF+ V    +++ Y+GES R +R++F  A++  PC+IF DE+DA+  RR    T 
Sbjct: 637 NESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETG 696

Query: 263 ADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQA 322
           A     R + +LL +MDG +   +V ++ ATNRPD +DPA+LRPGRLD+ + + LP    
Sbjct: 697 AS---VRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPAD 753

Query: 323 RLDILKIHAGPITKHG-------EIDYEAIV--KLSDGFNGADLRNVCTEAGMFAIRAD 372
           RL ILK     ITK+G       +++ EAI      D + GADL  +  EA + A+R +
Sbjct: 754 RLAILK----TITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQE 808



 Score =  174 bits (441), Expect = 1e-43
 Identities = 92/227 (40%), Positives = 140/227 (61%), Gaps = 1/227 (0%)

Query: 143 NVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVA 202
           NV + ++GG    ++E+ +++ + + +PE++  +G++PP+G LL+GPPG GKTLLA A+A
Sbjct: 261 NVKFEDVGGNDMTLKEVCKML-IHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIA 319

Query: 203 SQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTS 262
            +LD   LKV +  IV    GES + +RE+F  A  + PCIIF+DEIDAI  +R      
Sbjct: 320 GELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKD 379

Query: 263 ADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQA 322
            +R I   L+  ++ ++      RV +I ATNRPD+LDPAL R GR DR+I + +P+E +
Sbjct: 380 MERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEAS 439

Query: 323 RLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAI 369
           R  IL+     +      D+  +  L+ GF GADL  +C EA M A+
Sbjct: 440 RERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAV 486


>gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]
          Length = 1390

 Score =  174 bits (441), Expect = 1e-43
 Identities = 100/249 (40%), Positives = 147/249 (59%), Gaps = 15/249 (6%)

Query: 128 EVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLY 187
           +VDP+  + S      V +  +GGLS  I  L+E++  PL  PE+F++  I PP+GCL Y
Sbjct: 413 DVDPMQLDSS------VRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFY 466

Query: 188 GPPGTGKTLLARAVASQLDCNFLKVV-----SSSIVDKYIGESARLIREMFNYARDHQPC 242
           GPPGTGKTL+ARA+A++      +V       +  + K++GES R +R +F+ A   +P 
Sbjct: 467 GPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPS 526

Query: 243 IIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPA 302
           IIF DEID +   R S        I  TL+ L   MDG D+   + +I ATNR D++DPA
Sbjct: 527 IIFFDEIDGLAPVRSSRQDQIHSSIVSTLLAL---MDGLDSRGEIVVIGATNRLDSIDPA 583

Query: 303 LLRPGRLDRKIHIDLPNEQARLDILKIHAGPIT-KHGEIDYEAIVKLSDGFNGADLRNVC 361
           L RPGR DR+    LP+++AR +ILKIH      K  +   E + +   G+ GAD++++C
Sbjct: 584 LRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSIC 643

Query: 362 TEAGMFAIR 370
            EA + A+R
Sbjct: 644 AEAALCALR 652


>gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]
          Length = 1458

 Score =  171 bits (434), Expect = 8e-43
 Identities = 101/249 (40%), Positives = 145/249 (58%), Gaps = 15/249 (6%)

Query: 128 EVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLY 187
           +VDP+  + S      V +  IGGLS  I  L+E++  PL  PE+F++  I PP+GCL Y
Sbjct: 387 DVDPMNIDKS------VRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFY 440

Query: 188 GPPGTGKTLLARAVASQLDCNFLKVV-----SSSIVDKYIGESARLIREMFNYARDHQPC 242
           GPPGTGKTL+ARA+A++      KV       +  + K++GES R +R +F+ A   +P 
Sbjct: 441 GPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPS 500

Query: 243 IIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPA 302
           IIF DEID +   R S        I  TL+ L   MDG D    + +I ATNR D++DPA
Sbjct: 501 IIFFDEIDGLAPVRSSRQDQIHSSIVSTLLAL---MDGLDNRGEIVVIGATNRLDSIDPA 557

Query: 303 LLRPGRLDRKIHIDLPNEQARLDILKIHAGPIT-KHGEIDYEAIVKLSDGFNGADLRNVC 361
           L RPGR DR+   +LP+++AR  IL+IH      K  +     + +   G+ GAD++ +C
Sbjct: 558 LRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALC 617

Query: 362 TEAGMFAIR 370
           TEA + A+R
Sbjct: 618 TEAALIALR 626


>gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]
          Length = 773

 Score =  167 bits (422), Expect = 2e-41
 Identities = 93/238 (39%), Positives = 142/238 (59%), Gaps = 3/238 (1%)

Query: 143 NVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVA 202
           NV++  + G+ E  +EL+EV+E  L NP+ F  +G   PKG LL GPPGTGKTLLARAVA
Sbjct: 335 NVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAVA 393

Query: 203 SQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTS 262
            + D  F     S   + ++G  A  IR +F  A+ + PC+IF+DE+D++GG+R    + 
Sbjct: 394 GEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIE--SP 451

Query: 263 ADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQA 322
                ++T+ +LL +MDGF     V +I ATN P+ LD AL+RPGR D ++ +  P+ + 
Sbjct: 452 MHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKG 511

Query: 323 RLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQED 380
           R +ILK +   I     +D E I + + GF+GA+L N+  +A + A     + V  ++
Sbjct: 512 RTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKE 569


>gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]
          Length = 716

 Score =  167 bits (422), Expect = 2e-41
 Identities = 93/238 (39%), Positives = 142/238 (59%), Gaps = 3/238 (1%)

Query: 143 NVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVA 202
           NV++  + G+ E  +EL+EV+E  L NP+ F  +G   PKG LL GPPGTGKTLLARAVA
Sbjct: 278 NVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAVA 336

Query: 203 SQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTS 262
            + D  F     S   + ++G  A  IR +F  A+ + PC+IF+DE+D++GG+R    + 
Sbjct: 337 GEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIE--SP 394

Query: 263 ADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQA 322
                ++T+ +LL +MDGF     V +I ATN P+ LD AL+RPGR D ++ +  P+ + 
Sbjct: 395 MHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKG 454

Query: 323 RLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQED 380
           R +ILK +   I     +D E I + + GF+GA+L N+  +A + A     + V  ++
Sbjct: 455 RTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKE 512


>gi|5901990 katanin p60 subunit A 1 [Homo sapiens]
          Length = 491

 Score =  163 bits (412), Expect = 3e-40
 Identities = 108/288 (37%), Positives = 162/288 (56%), Gaps = 32/288 (11%)

Query: 129 VDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYG 188
           V+ L  ++  ++P NV + +I  L E  + L+E + LP+  PE F+ +   P KG L+ G
Sbjct: 192 VEALERDIISQNP-NVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRR-PWKGVLMVG 249

Query: 189 PPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDE 248
           PPGTGKTLLA+AVA++    F  V SS++  KY GES +L+R +F  AR + P  IF+DE
Sbjct: 250 PPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDE 309

Query: 249 IDAIGGRRFSEGTSADREIQRTL-MELLNQMDGF-------DTLHRVKMIMATNRPDTLD 300
           ID+I  RR   GTS + E  R +  ELL QMDG        D    V ++ ATN P  +D
Sbjct: 310 IDSICSRR---GTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDID 366

Query: 301 PALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNV 360
            AL R  RL+++I+I LP+ + R ++L+I    +    ++D  +I +  +G++GAD+ NV
Sbjct: 367 EALRR--RLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNV 424

Query: 361 CTEAGMFAIRAD-----------------HDFVVQEDFMKAVRKVADS 391
           C +A + A+R                   H     EDF  A++KV+ S
Sbjct: 425 CRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKS 472


>gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]
          Length = 361

 Score =  160 bits (406), Expect = 1e-39
 Identities = 114/329 (34%), Positives = 178/329 (54%), Gaps = 34/329 (10%)

Query: 82  KFIVKATNGPR-YVVGCRRQLDKSKLKPGTR-VALDMTTLTIMRYLPREVDPLVYNMSHE 139
           K++V A +  R   V  ++Q +K   + G + V L    ++I  +L   VDPL  NM   
Sbjct: 35  KWMVDAIDPTRKQKVEAQKQAEKLMKQIGVKNVKLSEYEMSIAAHL---VDPL--NM--- 86

Query: 140 DPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGII-PPKGCLLYGPPGTGKTLLA 198
              +V++S+I GL + I +L++ + LP+    LF+   ++ PPKG LLYGPPG GKTL+A
Sbjct: 87  ---HVTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIA 143

Query: 199 RAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFS 258
           +A A +  C F+ +  S++ DK+ GES +L   +F+ A   QP IIF+DEID+    R S
Sbjct: 144 KATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSS 203

Query: 259 EGTSADREIQRTLMELLNQMDGFDTLHRVKMIM--ATNRPDTLDPALLRPGRLDRKIHID 316
               A   ++   M L    DG DT H  ++I+  ATNRP  LD A++R  R+  + HI+
Sbjct: 204 SDHEATAMMKAQFMSL---WDGLDTDHSCQVIVMGATNRPQDLDSAIMR--RMPTRFHIN 258

Query: 317 LPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIR------ 370
            P  + R  ILK+          +D   + + +DGF+G+DL+ +C +A +  +R      
Sbjct: 259 QPALKQREAILKLILKNENVDRHVDLLEVAQETDGFSGSDLKEMCRDAALLCVREYVNST 318

Query: 371 --ADHDF-----VVQEDFMKAVRKVADSK 392
               HD      V Q+D  +A+ K+  SK
Sbjct: 319 SEESHDEDEIRPVQQQDLHRAIEKMKKSK 347


>gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  159 bits (402), Expect = 4e-39
 Identities = 96/236 (40%), Positives = 142/236 (60%), Gaps = 14/236 (5%)

Query: 143 NVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVA 202
           ++ + +I  L E  + LRE + LP+  P+ F+ +   P KG L+ GPPGTGKT+LA+AVA
Sbjct: 204 SIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRR-PWKGVLMVGPPGTGKTMLAKAVA 262

Query: 203 SQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTS 262
           ++    F  V SS++  KY GES +L+R +F  AR + P  IF+DEID+I  RR   GTS
Sbjct: 263 TECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRR---GTS 319

Query: 263 ADREIQRTL-MELLNQMDGF-------DTLHRVKMIMATNRPDTLDPALLRPGRLDRKIH 314
            + E  R +  ELL QMDG        D    V ++ ATN P  +D AL R  RL+++I+
Sbjct: 320 DEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIY 377

Query: 315 IDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIR 370
           I LP  + R ++LKI+   +    +I  E I +  +G++GAD+ NVC +A + A+R
Sbjct: 378 IPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMR 433


>gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  159 bits (402), Expect = 4e-39
 Identities = 96/236 (40%), Positives = 142/236 (60%), Gaps = 14/236 (5%)

Query: 143 NVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVA 202
           ++ + +I  L E  + LRE + LP+  P+ F+ +   P KG L+ GPPGTGKT+LA+AVA
Sbjct: 204 SIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRR-PWKGVLMVGPPGTGKTMLAKAVA 262

Query: 203 SQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTS 262
           ++    F  V SS++  KY GES +L+R +F  AR + P  IF+DEID+I  RR   GTS
Sbjct: 263 TECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRR---GTS 319

Query: 263 ADREIQRTL-MELLNQMDGF-------DTLHRVKMIMATNRPDTLDPALLRPGRLDRKIH 314
            + E  R +  ELL QMDG        D    V ++ ATN P  +D AL R  RL+++I+
Sbjct: 320 DEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIY 377

Query: 315 IDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIR 370
           I LP  + R ++LKI+   +    +I  E I +  +G++GAD+ NVC +A + A+R
Sbjct: 378 IPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMR 433


>gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]
          Length = 980

 Score =  158 bits (399), Expect = 9e-39
 Identities = 103/280 (36%), Positives = 160/280 (57%), Gaps = 26/280 (9%)

Query: 143 NVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVA 202
           +VS+ ++GGL E  +E+ E I+LPL +PEL   +G+    G LL+GPPGTGKTLLA+AVA
Sbjct: 701 SVSWHDVGGLQEVKKEILETIQLPLEHPELLS-LGL-RRSGLLLHGPPGTGKTLLAKAVA 758

Query: 203 SQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTS 262
           ++    FL V    +++ Y+G+S   +RE+F  AR   PCIIF DE+D++   R   G S
Sbjct: 759 TECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDS 818

Query: 263 ADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQA 322
               + R + +LL ++DG  +   V +I ATNRPD LDPALLRPGR D+ + +    ++A
Sbjct: 819 GG-VMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDRA 877

Query: 323 -RLDILKIHAGPITKHGEIDYE-AIVKLSD----GFNGADLRNVCTEAGMFAI-RADHD- 374
            +L +L      IT+  +++   ++V + D       GADL ++C++A   A+ R  HD 
Sbjct: 878 SQLRVL----SAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHDL 933

Query: 375 -----------FVVQEDFMKAVRKVADSKKLESKLDYKPV 403
                       +  ED ++A  ++  S   +  L YK +
Sbjct: 934 EEGLEPGSSALMLTMEDLLQAAARLQPSVSEQELLRYKRI 973



 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 89/370 (24%), Positives = 150/370 (40%), Gaps = 39/370 (10%)

Query: 3   IPGIPYERRLLI--MADPRDKALQDYRKKLLEHKEIDGRLKELREQLKELTKQYEKSEND 60
           +PG P+ R L I  ++ P      +Y   L  H +I   ++E          Q E  E  
Sbjct: 312 LPGPPFARELHIEIVSSPHYSTNGNYDGVLYRHFQIPRVVQEGDVLCVPTIGQVEILEGS 371

Query: 61  LKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDM--TT 118
            + L    ++  +V K + E      A +GP            + L   T  +L M  +T
Sbjct: 372 PEKLPRWREMFFKVKKTVGE------APDGPA----------SAYLADTTHTSLYMVGST 415

Query: 119 LTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGI 178
           L+ + +LP E   L  ++S             GL   + EL  V++ P   P      G 
Sbjct: 416 LSPVPWLPSEESTLWSSLSPP-----------GLEALVSELCAVLK-PRLQPGGALLTGT 463

Query: 179 IPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARD 238
                 LL GPPG GKT +  A  S L  + LKV  SS+  +  G     ++ +F+ AR 
Sbjct: 464 ---SSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARR 520

Query: 239 HQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDT 298
            +P ++ +  +D +G  R  +G   D  +   L  LL   D  ++   + ++  T+R   
Sbjct: 521 CRPAVLLLTAVDLLG--RDRDGLGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQD 578

Query: 299 LDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLR 358
           L PA ++      ++ +   +E  RL IL+     +    E++   + +   GF   DL 
Sbjct: 579 L-PADVQTA-FPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLY 636

Query: 359 NVCTEAGMFA 368
            + T +   A
Sbjct: 637 ALLTHSSRAA 646


>gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]
          Length = 466

 Score =  155 bits (391), Expect = 8e-38
 Identities = 95/275 (34%), Positives = 157/275 (57%), Gaps = 12/275 (4%)

Query: 108 PGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPL 167
           P  R+   ++    M    RE+  +V    +    N+ +++I GL    + ++E +  P+
Sbjct: 143 PSERLLKPLSAFIGMNSEMRELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPI 202

Query: 168 TNPELFQRVGIIPP-KGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESA 226
             P+LF   GI+ P KG LLYGPPGTGKTLLA+AVA++    F  + +S+IV K+ G+S 
Sbjct: 203 RYPQLF--TGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSE 260

Query: 227 RLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHR 286
           +L+R +F  AR H P  IF+DE++++  +R +          R   ELL QMDG      
Sbjct: 261 KLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSED 320

Query: 287 VKMIM-ATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITK------HGE 339
           +  ++ A+N P  LD A+LR  RL+++I +DLP+ +AR  ++     P++K      H E
Sbjct: 321 LVFVLAASNLPWELDCAMLR--RLEKRILVDLPSREARQAMIYHWLPPVSKSRALELHTE 378

Query: 340 IDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHD 374
           ++Y  + + ++G++G+D++ VC EA M  +R   D
Sbjct: 379 LEYSVLSQETEGYSGSDIKLVCREAAMRPVRKIFD 413


>gi|31742536 fidgetin-like 1 [Homo sapiens]
          Length = 674

 Score =  146 bits (369), Expect = 3e-35
 Identities = 87/239 (36%), Positives = 137/239 (57%), Gaps = 11/239 (4%)

Query: 136 MSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKT 195
           M H  P  V++ +I G+      ++E++  P+  P++F  +   PPKG LL+GPPGTGKT
Sbjct: 392 MDHGPP--VNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLR-GPPKGILLFGPPGTGKT 448

Query: 196 LLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGR 255
           L+ + +ASQ    F  + +SS+  K++GE  +++R +F  AR  QP +IF+DEID++  +
Sbjct: 449 LIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQ 508

Query: 256 RFSEGTSADREIQRTLMELLNQMDGFDTL--HRVKMIMATNRPDTLDPALLRPGRLDRKI 313
           R   G       +R   E L Q+DG  T    R+ ++ ATNRP  +D A  R  RL +++
Sbjct: 509 R---GDGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARR--RLVKRL 563

Query: 314 HIDLPNEQARLDI-LKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRA 371
           +I LP   AR  I + + +       E + E IV+ SD F+GAD+  +C EA +  IR+
Sbjct: 564 YIPLPEASARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIRS 622


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.139    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,794,499
Number of Sequences: 37866
Number of extensions: 635401
Number of successful extensions: 3347
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 103
Number of HSP's successfully gapped in prelim test: 50
Number of HSP's that attempted gapping in prelim test: 3023
Number of HSP's gapped (non-prelim): 316
length of query: 403
length of database: 18,247,518
effective HSP length: 105
effective length of query: 298
effective length of database: 14,271,588
effective search space: 4252933224
effective search space used: 4252933224
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.