BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|194306658 coiled-coil domain containing 77 isoform b [Homo sapiens] (456 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|194306660 coiled-coil domain containing 77 isoform b [Homo sa... 896 0.0 gi|194306658 coiled-coil domain containing 77 isoform b [Homo sa... 896 0.0 gi|14150165 coiled-coil domain containing 77 isoform a [Homo sap... 896 0.0 gi|194306535 coiled-coil domain containing 77 isoform b [Homo sa... 896 0.0 gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 74 4e-13 gi|34577114 cytomatrix protein p110 [Homo sapiens] 72 1e-12 gi|16262452 cingulin [Homo sapiens] 69 7e-12 gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 67 3e-11 gi|38044112 restin isoform b [Homo sapiens] 67 3e-11 gi|4506751 restin isoform a [Homo sapiens] 67 3e-11 gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 66 6e-11 gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 65 1e-10 gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 65 1e-10 gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 65 1e-10 gi|21735548 centrosomal protein 2 [Homo sapiens] 65 1e-10 gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 65 1e-10 gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 64 3e-10 gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 64 3e-10 gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 64 4e-10 gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 64 4e-10 gi|71061468 centromere protein E [Homo sapiens] 64 4e-10 gi|8922940 gamma-taxilin [Homo sapiens] 64 4e-10 gi|58535453 CDK5 regulatory subunit associated protein 2 isoform... 63 5e-10 gi|58535451 CDK5 regulatory subunit associated protein 2 isoform... 63 5e-10 gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 62 8e-10 gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 62 8e-10 gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 62 1e-09 gi|4885583 Rho-associated, coiled-coil containing protein kinase... 62 1e-09 gi|148746195 trichohyalin [Homo sapiens] 62 1e-09 gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 62 1e-09 >gi|194306660 coiled-coil domain containing 77 isoform b [Homo sapiens] Length = 456 Score = 896 bits (2316), Expect = 0.0 Identities = 456/456 (100%), Positives = 456/456 (100%) Query: 1 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 60 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK Sbjct: 1 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 60 Query: 61 LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 120 LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL Sbjct: 61 LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 120 Query: 121 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 180 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE Sbjct: 121 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 180 Query: 181 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 240 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT Sbjct: 181 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 240 Query: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL Sbjct: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300 Query: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT Sbjct: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360 Query: 361 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA Sbjct: 361 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420 Query: 421 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC Sbjct: 421 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456 >gi|194306658 coiled-coil domain containing 77 isoform b [Homo sapiens] Length = 456 Score = 896 bits (2316), Expect = 0.0 Identities = 456/456 (100%), Positives = 456/456 (100%) Query: 1 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 60 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK Sbjct: 1 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 60 Query: 61 LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 120 LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL Sbjct: 61 LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 120 Query: 121 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 180 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE Sbjct: 121 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 180 Query: 181 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 240 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT Sbjct: 181 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 240 Query: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL Sbjct: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300 Query: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT Sbjct: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360 Query: 361 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA Sbjct: 361 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420 Query: 421 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC Sbjct: 421 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456 >gi|14150165 coiled-coil domain containing 77 isoform a [Homo sapiens] Length = 488 Score = 896 bits (2316), Expect = 0.0 Identities = 456/456 (100%), Positives = 456/456 (100%) Query: 1 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 60 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK Sbjct: 33 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 92 Query: 61 LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 120 LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL Sbjct: 93 LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 152 Query: 121 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 180 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE Sbjct: 153 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 212 Query: 181 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 240 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT Sbjct: 213 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 272 Query: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL Sbjct: 273 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 332 Query: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT Sbjct: 333 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 392 Query: 361 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA Sbjct: 393 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 452 Query: 421 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC Sbjct: 453 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 488 >gi|194306535 coiled-coil domain containing 77 isoform b [Homo sapiens] Length = 456 Score = 896 bits (2316), Expect = 0.0 Identities = 456/456 (100%), Positives = 456/456 (100%) Query: 1 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 60 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK Sbjct: 1 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 60 Query: 61 LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 120 LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL Sbjct: 61 LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 120 Query: 121 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 180 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE Sbjct: 121 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 180 Query: 181 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 240 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT Sbjct: 181 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 240 Query: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL Sbjct: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300 Query: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT Sbjct: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360 Query: 361 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA Sbjct: 361 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420 Query: 421 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC Sbjct: 421 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456 >gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sapiens] Length = 570 Score = 73.6 bits (179), Expect = 4e-13 Identities = 90/401 (22%), Positives = 185/401 (46%), Gaps = 37/401 (9%) Query: 27 LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCL 86 L Y Q + + E E DL+ +L K +L+Q +A QK +D + Sbjct: 134 LYYSQHAVKQLEGEARDLISRLH-------DSWKFAGELEQALSAVAT-QKKKADRYIEE 185 Query: 87 FQEREHVLRLYSENDRLRIRELEDKK-KIQNLLALVGTDAGEVTYFCKEPPHKVT----- 140 + L L + + EL++K K+Q L LV ++ E+ KE K+ Sbjct: 186 LTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLL 245 Query: 141 ILQKTIQA----VGECEQSESSAFKADPKISK--RRPSRERKESSEHYQRDIQTLILQVE 194 + Q+ +QA +G+ QS S+ +A + ++ R +++++E + IQ +++ Sbjct: 246 LPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQ 305 Query: 195 ALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYEST 254 + ++ EQ + R Q E + E + ++ ++ + KI+EL + +H +++ + Sbjct: 306 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE-KIRELEEKMHEQEKIREQEE 364 Query: 255 K--DFLQLRSENQNKE---KSWMLEKD--NLMSKIKQYRVQCKKKEDKIGKVLPVMHESH 307 K + ++R + + +E K W E+ KI++ +++E+K+G+ M E Sbjct: 365 KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQE 424 Query: 308 HAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRL 367 E + ++ QE+K+ +EQ + E+ +IRE+E M +E + + GK Sbjct: 425 EEMQEQEEKMRR---QEEKI----REQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMC 477 Query: 368 QIMTKRYEALERRRILEVEGFKTDIKVLRQ--KLKDLEQML 406 + K E E+ R E + + + K+ Q K+++ E+M+ Sbjct: 478 EQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMM 518 Score = 70.5 bits (171), Expect = 3e-12 Identities = 94/464 (20%), Positives = 213/464 (45%), Gaps = 66/464 (14%) Query: 12 SPEDRLAKLHPSKELLEYYQKKMAECEAENEDLL--KKLELYKEACEGQHKLECDLQQRE 69 SPED H +E L ++ E + + +L +K EL QH ++ Q E Sbjct: 94 SPEDEQKASHQHQEAL----RRELEAQVQTIRILTCQKTELQMALYYSQHAVK----QLE 145 Query: 70 EEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVT 129 E +L L D E E L + + R +E+ K ++ L+L + T Sbjct: 146 GEARDLISRLHDSWK-FAGELEQALSAVATQKKKADRYIEELTKERDALSL---ELYRNT 201 Query: 130 YFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRR--------PSRERKESSEH 181 +E K LQ+ +Q V +SE S + + K KR+ P ++ + ++H Sbjct: 202 ITDEELKEKNAKLQEKLQLV----ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADH 257 Query: 182 YQRDIQTLILQVEALQAQLGEQTKLSREQIEGLI-EDRRIHLEEIQVQHQRNQNKIKELT 240 +++Q++ +++A + +L+++Q E + ++ +I E ++Q Q + KI+E Sbjct: 258 LGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQ--EEKIREQE 315 Query: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300 + + +E+++E + E +++ M EK+ + ++++ + +K ++ Sbjct: 316 EKMRRQEEMMWE--------KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQ----- 362 Query: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360 E + E I+ + + QE K+ QE+ I +EE +IRE+E E+ +++ Sbjct: 363 ----EEKRQEEEKIREQEKRQEQEAKMWR--QEEKIREQEE--KIREQE----EMMQEQE 410 Query: 361 NKMGKRLQIMTKRYEALE------RRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNAR 414 KMG++ + M ++ E ++ RR+ ++ + I+ +K+++ E+M+ + + Sbjct: 411 EKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQ--EEK 468 Query: 415 ANQDLALLCE----VRDSNRRAHKIQGELKNLKSKVFGLENELR 454 + +CE +++ + + + +++ + K+ E ++R Sbjct: 469 MGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 512 Score = 60.5 bits (145), Expect = 3e-09 Identities = 75/361 (20%), Positives = 163/361 (45%), Gaps = 53/361 (14%) Query: 10 LPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQRE 69 LP + + H KEL K A+ E ENE L +L +E E + E +Q+RE Sbjct: 246 LPQQQLQAEADHLGKELQSVSAKLQAQVE-ENE-LWNRLNQQQE--EKMWRQEEKIQERE 301 Query: 70 EEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRE---LEDKKKIQNLLALVGTDAG 126 E+I E ++ + + + + ++ E ++ + +++R +E E ++KI+ L Sbjct: 302 EKIQEQEEKIREQEEKMRRQEE---MMWEKEEKMRRQEEMMWEKEEKIREL--------- 349 Query: 127 EVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDI 186 +E H+ Q+ I+ E Q E + + + + ++E + I Sbjct: 350 ------EEKMHE----QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 399 Query: 187 QTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHT 246 + ++ + ++GEQ + EQ E ++E + + +R + KI+E K + Sbjct: 400 REQEEMMQEQEEKMGEQEEKMWEQEE--------EMQEQEEKMRRQEEKIREQEKKIREQ 451 Query: 247 QELLYESTKDFLQLRSENQNKEKSWMLEKDNLMS-----------KIKQYRVQCKKKEDK 295 +E + E ++ +Q + E +++ M E++ M KI++ + +++E+K Sbjct: 452 EEKIREQ-EEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEK 510 Query: 296 IGKVLPVMHESHHAQSEYIKSL--KDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRR 353 I + +M E E + + +++ +QE++ QE+ + E+ R+R++E + Sbjct: 511 IREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE--KMREQEVRLRQQEEKMQ 568 Query: 354 E 354 E Sbjct: 569 E 569 Score = 58.9 bits (141), Expect = 9e-09 Identities = 84/406 (20%), Positives = 184/406 (45%), Gaps = 45/406 (11%) Query: 24 KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQ 83 K+ Y ++ E +A + +L + +E E KL+ LQ E E +E+Q + +++ Sbjct: 177 KKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELK 236 Query: 84 VCLFQEREHVL----RLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCK---EPP 136 L ER +L +L +E D L K++Q++ A + E + + + Sbjct: 237 RKL--ERAKLLLPQQQLQAEADHLG-------KELQSVSAKLQAQVEENELWNRLNQQQE 287 Query: 137 HKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSR--ERKESSEHYQRDIQTLILQVE 194 K+ ++ IQ E Q + + + +R+ E++E + + ++ Sbjct: 288 EKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 347 Query: 195 ALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQ----RNQNKIKELTKNLHHTQELL 250 L+ ++ EQ K+ REQ E E+ +I +E + + + R + KI+E + + +E++ Sbjct: 348 ELEEKMHEQEKI-REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMM 406 Query: 251 YESTKDFLQLRSENQNKEKSW-----MLEKDNLM----SKIKQYRVQCKKKEDKIGKVLP 301 E Q + +EK W M E++ M KI++ + +++E+KI + Sbjct: 407 QE------QEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 460 Query: 302 VMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRR---EIFKD 358 +M E E + ++ + ++ + Q + E+ +IRE+E R E+ ++ Sbjct: 461 MMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQE 520 Query: 359 RTNKMGKRLQIMTKRYEAL----ERRRILEVEGFKTDIKVLRQKLK 400 + KM ++ + M ++ E + E+ R E + + ++++ +Q+ K Sbjct: 521 QEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEK 566 >gi|34577114 cytomatrix protein p110 [Homo sapiens] Length = 957 Score = 71.6 bits (174), Expect = 1e-12 Identities = 105/468 (22%), Positives = 206/468 (44%), Gaps = 63/468 (13%) Query: 31 QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQER 90 Q K+ +N D + +E+ KE+ + + LQ E+ L+ L + + L ++ Sbjct: 454 QTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQT---EVDALRLRLEEKESFLNKKT 510 Query: 91 EHVLRLYSENDRL--RIRELED------------KKKIQNLLALVGTDAGEVTYFCKEPP 136 + + L E L IR+++D +KKI+NL + ++T Sbjct: 511 KQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVK 570 Query: 137 HKVTILQKTIQAVGECEQ--SESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVE 194 T T A+ E+ SE K + R RER E E ++++ + L +V Sbjct: 571 SLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVN 630 Query: 195 ALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYEST 254 ALQA+L E+ E + D + H + + +K+K L + +E E + Sbjct: 631 ALQAELTEK--------ESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKE---ECS 679 Query: 255 KDFLQLRSENQNKEKSWMLEKDNLMSKIKQ-------YRVQCKKKEDKIGKVLPVMHESH 307 K QL+ + ++ S M +IKQ YR +C K + ++ ++L ++ E Sbjct: 680 KLEAQLKKAHNIEDDSRM--NPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVE 737 Query: 308 HAQSEYIK--------SLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDR 359 + +++ K +L+ Q KK++N+ Q + +++ A++ EE R + D Sbjct: 738 NEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLE-KKKNAQLLEEVRRREDSMADN 796 Query: 360 T---------NKMGKRLQIM--TKRYEALERRRILEVEGFKTDIKVLRQK-LKDLEQMLY 407 + N + K Q + TK A ++ + E E ++++ R+K L+++ +M Sbjct: 797 SQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQ 856 Query: 408 KATVNARANQDLAL-LCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454 +A + A + +D + L E+ S ++ K Q E+ LK + L ++L+ Sbjct: 857 EALLAAISEKDANIALLELSASKKK--KTQEEVMALKREKDRLVHQLK 902 Score = 35.8 bits (81), Expect = 0.083 Identities = 33/147 (22%), Positives = 71/147 (48%), Gaps = 13/147 (8%) Query: 273 LEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQ 332 L+K+ ++ K + R+ K++ + V HE + I++L+D+L ++ L+++ Q Sbjct: 190 LKKERVLRKEEAARMSVLKEQ------MRVSHEENQHLQLTIQALQDELRTQRDLNHLLQ 243 Query: 333 EQCISLEEELARIR-EEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTD 391 ++ + E I EE RR + ++ K L ++ K E +E L +E K Sbjct: 244 QESGNRGAEHFTIELTEENFRR--LQAEHDRQAKELFLLRKTLEEME----LRIETQKQT 297 Query: 392 IKVLRQKLKDLEQMLYKATVNARANQD 418 + + +K L +ML + +++ +D Sbjct: 298 LNARDESIKKLLEMLQSKGLPSKSLED 324 Score = 31.2 bits (69), Expect = 2.0 Identities = 30/153 (19%), Positives = 60/153 (39%), Gaps = 20/153 (13%) Query: 294 DKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRR 353 D+ G + H HH ++ ++D + + L+ +L ++ E + R Sbjct: 119 DQHGGLTGSSHHHHHQVPSMLRQVRDSTM-------------LDLQAQLKELQRENDLLR 165 Query: 354 EIFKDRTNKMGKRLQ-IMTKRYEALERRRILEVEG------FKTDIKVLRQKLKDLEQML 406 + + +K+G + I T L++ R+L E K ++V ++ + L+ + Sbjct: 166 KELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTI 225 Query: 407 YKATVNARANQDLALLCEVRDSNRRAHKIQGEL 439 R +DL L + NR A EL Sbjct: 226 QALQDELRTQRDLNHLLQQESGNRGAEHFTIEL 258 >gi|16262452 cingulin [Homo sapiens] Length = 1203 Score = 69.3 bits (168), Expect = 7e-12 Identities = 95/472 (20%), Positives = 198/472 (41%), Gaps = 74/472 (15%) Query: 42 EDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSEND 101 +DLL+ EL +E EG+ ++E L+ RE E+ L+ AL + QE EHV + Y + Sbjct: 467 KDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDT 526 Query: 102 RLRIRELED--------KKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECE 153 R ++D + + Q + ALV E+ +E H ++ QK + + + Sbjct: 527 EQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATK 586 Query: 154 Q--------SESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGE-QT 204 Q E + KI + E+ +S R ++ L ++ Q +L E Q Sbjct: 587 QELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQA 646 Query: 205 KLSREQIEGLIEDRRI---------------HLEEIQVQHQRNQNKIKE----------- 238 + +++ G DR + LEE +Q Q+ ++++ Sbjct: 647 ERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMV 706 Query: 239 --------------LTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLE-KDNLMSKIK 283 + L TQE E + L L E Q KE +++ + + ++++ Sbjct: 707 AEAEATVLGQRRAAVETTLRETQEENDEFRRRILGL--EQQLKETRGLVDGGEAVEARLR 764 Query: 284 QYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQ-EKKLSNMYQEQCISLEEEL 342 + + ++ ++ + L E + + ++L+ +L + ++ L+ + QEQ + L Sbjct: 765 DKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQ-----QTL 819 Query: 343 ARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDL 402 R EEEG +RE+ + ++ ++ +++ + + L + E K ++ L+ +L+D Sbjct: 820 NRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDY 879 Query: 403 EQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454 ++ + +A+ + +D A K G L L+ ++ L L+ Sbjct: 880 KEKARREVADAQR--------QAKDWASEAEKTSGGLSRLQDEIQRLRQALQ 923 Score = 39.3 bits (90), Expect = 0.007 Identities = 57/252 (22%), Positives = 116/252 (46%), Gaps = 31/252 (12%) Query: 14 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD----LQQRE 69 +D + +L ++ L+ Q + + E L ++L+ ++ E + + + D L+ E Sbjct: 912 QDEIQRL---RQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLE 968 Query: 70 EEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNL----LALVGTDA 125 E+++ L+ L + + + + V R + D+LR ++++ Q+L ++L + Sbjct: 969 EKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNK 1028 Query: 126 GEVTYFC-----KEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESS- 179 T ++P ++ L+ Q + E Q+E K + + R+ R+ KE S Sbjct: 1029 DLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEERE-KTVLQSTNRKLERKVKELSI 1087 Query: 180 ------EHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRN- 232 +H L L+V+AL+ Q+ E + E+IE L R+ E++ QH+ N Sbjct: 1088 QIEDERQHVNDQKDQLSLRVKALKRQVDE----AEEEIERLDGLRKKAQREVEEQHEVNE 1143 Query: 233 --QNKIKELTKN 242 Q +IK L K+ Sbjct: 1144 QLQARIKSLEKD 1155 >gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] Length = 1411 Score = 67.4 bits (163), Expect = 3e-11 Identities = 110/472 (23%), Positives = 208/472 (44%), Gaps = 88/472 (18%) Query: 24 KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD------------LQQREEE 71 KEL Q +M E ++L K LE KEA Q KLE + L+Q E+E Sbjct: 895 KELKHQLQVQMENTLKEQKELKKSLEKEKEASH-QLKLELNSMQEQLIQAQNTLKQNEKE 953 Query: 72 IAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYF 131 +LQ +++++ Q+++ + L E L+I L+ K +++N L T A + Sbjct: 954 EQQLQGNINELKQSSEQKKKQIEALQGE---LKIAVLQ-KTELENKLQQQLTQAAQELAA 1009 Query: 132 CKEPPHKVTILQ----------KTIQAVGECEQSESSAFKADPKISKRRPSRERKE--SS 179 KE K+++LQ K +Q+ +SE A + D K + + S +++ S+ Sbjct: 1010 EKE---KISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISN 1066 Query: 180 EHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKEL 239 + + LI +++ +A L EQ +EQ +++R L++IQ + + ++ Sbjct: 1067 RNQIGNQNKLIQELKTAKATL-EQDSAKKEQ---QLQERCKALQDIQKEKSLKEKELVNE 1122 Query: 240 TKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKV 299 L +E+ K+ +L E ++ + + E NL KQ +Q +K + GK Sbjct: 1123 KSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNL-KDAKQLLIQ--QKLELQGKA 1179 Query: 300 LPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELAR--IREEEGMRREIFK 357 SLK + QEK+ + ++Q EEEL + I +E + EI Sbjct: 1180 ---------------DSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEI-- 1222 Query: 358 DRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLR-------QKLKDLEQM----- 405 K ++ K++E E + +++ ++ ++ +++ +LE+ Sbjct: 1223 -------KEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLR 1275 Query: 406 ----LYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENEL 453 + +ATV ++ ALL R K +GE++ L++KV L+ +L Sbjct: 1276 GEIAVLEATVQNNQDERRALL-------ERCLKGEGEIEKLQTKVLELQRKL 1320 Score = 50.8 bits (120), Expect = 2e-06 Identities = 83/464 (17%), Positives = 193/464 (41%), Gaps = 56/464 (12%) Query: 31 QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQER 90 Q + E + +E+L K+LE Y+ + + K + + E+ L++ L + Q F + Sbjct: 96 QASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIK 155 Query: 91 EHVLRLYSENDRLRIRELED-KKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQ----KT 145 + + L+ + E+ D K K +L +VT +E + T++Q + Sbjct: 156 Q-MKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTEL 214 Query: 146 IQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTK 205 +Q G + + + + ER+ SE + + + L Q + +A + + Sbjct: 215 LQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQL-- 272 Query: 206 LSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQ 265 R ++ ++ ++++E+Q + ++ + ELT+ E L + +D+ +L E Sbjct: 273 --RSELAKGPQEVAVYVQELQ----KLKSSVNELTQKNQTLTENLLKKEQDYTKLE-EKH 325 Query: 266 NKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESH---HAQSEYIKSLKDKL- 321 N+E + K N+ + + Q + C++ + ++ +H H + E + LK++L Sbjct: 326 NEES---VSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELS 382 Query: 322 ----------VQEKKLSNMYQEQ---CISLEEEL------------------ARIREEEG 350 + K+L +E+ + L+ E+ R++E+ Sbjct: 383 EVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQ 442 Query: 351 MRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKAT 410 + E D+ ++ LQ+ R E + ++ + + +Q+ ++ + + T Sbjct: 443 LSSEKLMDKEQQVAD-LQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTT 501 Query: 411 VNAR-ANQDL-ALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 452 R A DL +L ++ D +++ ++ L+ K + LE E Sbjct: 502 AKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKE 545 Score = 47.4 bits (111), Expect = 3e-05 Identities = 79/406 (19%), Positives = 168/406 (41%), Gaps = 51/406 (12%) Query: 73 AELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFC 132 A+LQ L Q L +++ + ++ ++ D++ + L+DK++ ++ Sbjct: 663 ADLQNHLDTAQNALQDKQQELNKITTQLDQVTAK-LQDKQE----------HCSQLESHL 711 Query: 133 KEPPHK-VTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLIL 191 KE K +++ QKT + G+ ++ E+ + + + S+E+ QR + T Sbjct: 712 KEYKEKYLSLEQKTEELEGQIKKLEADSLEV-------KASKEQALQDLQQQRQLNT--- 761 Query: 192 QVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQR--NQNKIKELTKN----LHH 245 +E +L +Q ++ +E + D + E ++ Q+ Q + K++ K L Sbjct: 762 DLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQ 821 Query: 246 TQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHE 305 ++ +E + +Q K K +EK+ LM+++ + + K D + + Sbjct: 822 ETKIQHEELNNRIQTTVTELQKVK---MEKEALMTELSTVKDKLSKVSDSLKNSKSEFEK 878 Query: 306 SHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGK 365 + I L+ + K + E + ++EL + E+E K N M + Sbjct: 879 ENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQE 938 Query: 366 RL---QIMTKRYEALER--------------RRILEVEGFKTDIKVLRQKLKDLEQMLYK 408 +L Q K+ E E+ ++ ++E + ++K+ + +LE L + Sbjct: 939 QLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQ 998 Query: 409 ATVNARANQDLALLCE-VRDSNRRAHKIQGELKNLKSKVFGLENEL 453 +A Q+LA E + K Q K L+S +G E+EL Sbjct: 999 QL--TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESEL 1042 Score = 45.8 bits (107), Expect = 8e-05 Identities = 69/421 (16%), Positives = 182/421 (43%), Gaps = 24/421 (5%) Query: 18 AKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQK 77 A LH + Q +++ E + +L E E KL+ +L + E + L+ Sbjct: 337 ATLHQKDLDCQQLQSRLSASETSLHRIHVELS---EKGEATQKLKEELSEVETKYQHLKA 393 Query: 78 ALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPH 137 +Q ++ +H L+L SE ++L + LE ++++ + + + Sbjct: 394 EFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQ 453 Query: 138 KVTILQKTIQAVGE-CEQSESSAFKADPKISKRRPSRERKESSEHYQ----RDIQTLILQ 192 +V LQ + + E ++ +++ + ++ K + + +++ + R+ Q Sbjct: 454 QVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQN---D 510 Query: 193 VEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKE---LTKNLHHTQEL 249 +E + Q+G++ + + +E L++ + ++ ++ + + KI+ T L+ QE Sbjct: 511 LEQVLRQIGDKDQ-KIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEK 569 Query: 250 LYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHA 309 + + QL + +N+ +S ++NL ++++ + + +D++ + ++E + Sbjct: 570 NHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQ 629 Query: 310 QSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRL-- 367 +E + + +Q K + + + + A ++ + +D+ ++ K Sbjct: 630 LNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQ 689 Query: 368 --QIMTKRYEALERRRILE--VEGFKTDIKVLRQKLKDLEQMLYKA---TVNARANQDLA 420 Q+ K + E LE ++ +K L QK ++LE + K ++ +A+++ A Sbjct: 690 LDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQA 749 Query: 421 L 421 L Sbjct: 750 L 750 Score = 44.7 bits (104), Expect = 2e-04 Identities = 57/301 (18%), Positives = 134/301 (44%), Gaps = 45/301 (14%) Query: 42 EDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSEND 101 +D KK + +E C+ ++ + +E+E+ + L++++ ++ + + +L N+ Sbjct: 1089 QDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKL---NE 1145 Query: 102 RLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSA-- 159 L+ +LE K+I NL DA K ++Q+ ++ G+ + +++ Sbjct: 1146 ELKSHKLESIKEITNL-----KDA------------KQLLIQQKLELQGKADSLKAAVEQ 1188 Query: 160 FKADPKISKRRPSRERKESSEHY---QRDIQTLILQVEALQAQLGEQTKLSREQIEGLIE 216 K + +I K + +E +E + + + + + I + E + E QI L E Sbjct: 1189 EKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNE 1248 Query: 217 DRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEK- 275 +L ++ + Q +Q ++ EL K T +L E L+ +N E+ +LE+ Sbjct: 1249 ----NLGTVKKEWQSSQRRVSELEK---QTDDLRGEIA--VLEATVQNNQDERRALLERC 1299 Query: 276 -------DNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLS 328 + L +K+ + + +K ++ V + E+ Q ++ ++L K ++ ++ Sbjct: 1300 LKGEGEIEKLQTKVLELQ---RKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQ 1356 Query: 329 N 329 N Sbjct: 1357 N 1357 >gi|38044112 restin isoform b [Homo sapiens] Length = 1392 Score = 67.0 bits (162), Expect = 3e-11 Identities = 98/476 (20%), Positives = 204/476 (42%), Gaps = 43/476 (9%) Query: 10 LPSPEDRLAKLHPSKELLEYYQKKMAECEAE-NEDLLKKLELYKEACEGQHKLECDLQQR 68 L + ++ L+++ KE LE + + E AE +E+ + +E H+ E Sbjct: 786 LTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNML 845 Query: 69 EEEIAELQKALSDMQVCLFQEREHVLRLYS-----ENDRLRIRELEDKK-----KIQNLL 118 ++ +L++ L+DM+ ++ E +L END I ++ K+ + L Sbjct: 846 SSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDEL 905 Query: 119 ALVGTDAGEVTYFCKEPPHKVTILQKTIQAVG-ECEQSESSAFKADPKISKRRPSRERKE 177 L D E+ + + LQK+I+ + + EQS+ A K K + + ERK Sbjct: 906 RLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAK---KHEEEKKELERKL 962 Query: 178 SSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHL----EEIQVQHQRNQ 233 S ++ ++T Q + L+A+ T ++ + E ++++ + L ++++ + N Sbjct: 963 SD--LEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENS 1020 Query: 234 NKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEK-----------DNLMSKI 282 ++EL + + T + E KEK+ L N + + Sbjct: 1021 GLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL 1080 Query: 283 KQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEEL 342 K+ ++ ++ +K ++L V ++ + I++LK Q+ + + QE+ + L EEL Sbjct: 1081 KENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEEL 1140 Query: 343 ARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKV----LRQK 398 R R+E +++ ++R + + +L M KR + E + I + L +K Sbjct: 1141 GRSRDEVTSHQKLEEER-SVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEK 1199 Query: 399 LKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454 +LE++ + TV N L V ++ + L+ KV LE +L+ Sbjct: 1200 DAELEKLRNEVTVLRGENASAKSLHSV------VQTLESDKVKLELKVKNLELQLK 1249 Score = 46.6 bits (109), Expect = 5e-05 Identities = 80/409 (19%), Positives = 171/409 (41%), Gaps = 45/409 (11%) Query: 60 KLECDLQQREEEIAELQKALS--------DMQVCLFQEREHVLRLYSENDRLRIRELEDK 111 +LE DL R +E+AEL++ L DM + L QE + S ++L + + + Sbjct: 468 ELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE------ISSLQEKLEVTRTDHQ 521 Query: 112 KKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRP 171 ++I +L G A E T+ KE T +K + + A K + + Sbjct: 522 REITSLKEHFG--AREETHQ-KEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWK 578 Query: 172 SRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQR 231 S+ + H Q + + + L + E +L + QIE + D + +E +Q Q Sbjct: 579 SKLETAIASHQQAMEELKVSFSKGLGTETAEFAEL-KTQIEKMRLDYQHEIENLQNQQDS 637 Query: 232 NQNK-IKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCK 290 + KE+ +++ E +RS+ E ++E ++ ++K+++ ++ K Sbjct: 638 ERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVK 697 Query: 291 KKEDKIGKVLPVMHESHHAQSEYIKSLKDKL-VQEKKLSNMYQEQCISLE--EELARIRE 347 + L V+ + Q++ I + +L E+KL ++ + S E E+ ++R+ Sbjct: 698 E--------LEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQ 749 Query: 348 EEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLY 407 + + K K L+I + E++G + + L++ L ++ Q Sbjct: 750 Q--------LEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQ--- 798 Query: 408 KATVNARANQDLALLCE-VRDSNRRAHKIQGELKNLKSKVFGLENELRL 455 V ++L +L E +++ A +Q ++ +K+ E + + Sbjct: 799 ---VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNM 844 >gi|4506751 restin isoform a [Homo sapiens] Length = 1427 Score = 67.0 bits (162), Expect = 3e-11 Identities = 98/476 (20%), Positives = 204/476 (42%), Gaps = 43/476 (9%) Query: 10 LPSPEDRLAKLHPSKELLEYYQKKMAECEAE-NEDLLKKLELYKEACEGQHKLECDLQQR 68 L + ++ L+++ KE LE + + E AE +E+ + +E H+ E Sbjct: 821 LTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNML 880 Query: 69 EEEIAELQKALSDMQVCLFQEREHVLRLYS-----ENDRLRIRELEDKK-----KIQNLL 118 ++ +L++ L+DM+ ++ E +L END I ++ K+ + L Sbjct: 881 SSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDEL 940 Query: 119 ALVGTDAGEVTYFCKEPPHKVTILQKTIQAVG-ECEQSESSAFKADPKISKRRPSRERKE 177 L D E+ + + LQK+I+ + + EQS+ A K K + + ERK Sbjct: 941 RLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAK---KHEEEKKELERKL 997 Query: 178 SSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHL----EEIQVQHQRNQ 233 S ++ ++T Q + L+A+ T ++ + E ++++ + L ++++ + N Sbjct: 998 SD--LEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENS 1055 Query: 234 NKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEK-----------DNLMSKI 282 ++EL + + T + E KEK+ L N + + Sbjct: 1056 GLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL 1115 Query: 283 KQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEEL 342 K+ ++ ++ +K ++L V ++ + I++LK Q+ + + QE+ + L EEL Sbjct: 1116 KENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEEL 1175 Query: 343 ARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKV----LRQK 398 R R+E +++ ++R + + +L M KR + E + I + L +K Sbjct: 1176 GRSRDEVTSHQKLEEER-SVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEK 1234 Query: 399 LKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454 +LE++ + TV N L V ++ + L+ KV LE +L+ Sbjct: 1235 DAELEKLRNEVTVLRGENASAKSLHSV------VQTLESDKVKLELKVKNLELQLK 1284 Score = 46.6 bits (109), Expect = 5e-05 Identities = 80/409 (19%), Positives = 171/409 (41%), Gaps = 45/409 (11%) Query: 60 KLECDLQQREEEIAELQKALS--------DMQVCLFQEREHVLRLYSENDRLRIRELEDK 111 +LE DL R +E+AEL++ L DM + L QE + S ++L + + + Sbjct: 503 ELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE------ISSLQEKLEVTRTDHQ 556 Query: 112 KKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRP 171 ++I +L G A E T+ KE T +K + + A K + + Sbjct: 557 REITSLKEHFG--AREETHQ-KEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWK 613 Query: 172 SRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQR 231 S+ + H Q + + + L + E +L + QIE + D + +E +Q Q Sbjct: 614 SKLETAIASHQQAMEELKVSFSKGLGTETAEFAEL-KTQIEKMRLDYQHEIENLQNQQDS 672 Query: 232 NQNK-IKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCK 290 + KE+ +++ E +RS+ E ++E ++ ++K+++ ++ K Sbjct: 673 ERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVK 732 Query: 291 KKEDKIGKVLPVMHESHHAQSEYIKSLKDKL-VQEKKLSNMYQEQCISLE--EELARIRE 347 + L V+ + Q++ I + +L E+KL ++ + S E E+ ++R+ Sbjct: 733 E--------LEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQ 784 Query: 348 EEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLY 407 + + K K L+I + E++G + + L++ L ++ Q Sbjct: 785 Q--------LEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQ--- 833 Query: 408 KATVNARANQDLALLCE-VRDSNRRAHKIQGELKNLKSKVFGLENELRL 455 V ++L +L E +++ A +Q ++ +K+ E + + Sbjct: 834 ---VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNM 879 >gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sapiens] Length = 668 Score = 66.2 bits (160), Expect = 6e-11 Identities = 74/389 (19%), Positives = 180/389 (46%), Gaps = 40/389 (10%) Query: 19 KLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKL----ECDLQQREEEIAE 74 K+ +E ++ +++K+ E E + + +K+ +E Q ++ E ++++EE + E Sbjct: 301 KMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 360 Query: 75 LQKALSDMQVCLFQEREHVLRLYSE-NDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCK 133 ++ + ++ ++++ E + L + +++ +IRE E+K++ + Sbjct: 361 KEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEE----------------- 403 Query: 134 EPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQV 193 K+ +K + + + E + + KI ++ R+E H Q I+ + Sbjct: 404 ----KIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQ 459 Query: 194 EALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYES 253 E Q ++ Q + REQ E + ++H +E + ++ + K+ + +H +E + E Sbjct: 460 E--QEEMWRQEEKIREQEEIWRQKEKMHEQE---KIRKQEEKVWRQEEKMHDQEEKIREQ 514 Query: 254 TKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESH--HAQS 311 + R E + +E+ + + KI++ +++E+K+G+ M E Q Sbjct: 515 EEKMW--RQEEKIREQEEKIREQE--EKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQE 570 Query: 312 EYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMT 371 E I+ ++K+ ++K+ +E+ EE +IRE+E M +E + + K + Sbjct: 571 EKIREQEEKIREQKEKIREQEEKIWEQEE---KIREQEEMMQEQEEKMWEQEEKMCEQEE 627 Query: 372 KRYEALERRRILEVEGFKTDIKVLRQKLK 400 K E E+ R E + ++ ++++ +Q+ K Sbjct: 628 KMQEQEEKMRRQEEKMWEQEVRLRQQEEK 656 Score = 62.4 bits (150), Expect = 8e-10 Identities = 90/475 (18%), Positives = 215/475 (45%), Gaps = 65/475 (13%) Query: 27 LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCL 86 L Y Q + + E E DL+ +L K +L+Q +A QK +D + Sbjct: 146 LYYSQHAVKQLEGEARDLISRLH-------DSWKFAGELEQALSAVAT-QKKKADRYIEE 197 Query: 87 FQEREHVLRLYSENDRLRIRELEDKK-KIQNLLALVGTDAGEVTYFCKEPPHKVT----- 140 + L L + + EL++K K+Q L LV ++ E+ KE K+ Sbjct: 198 LTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLL 257 Query: 141 ILQKTIQA----VGECEQSESSAFKADPKISK--RRPSRERKESSEHYQRDIQTLILQVE 194 + Q+ +QA +G+ QS S+ +A + ++ R +++++E + IQ +++ Sbjct: 258 LPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQ 317 Query: 195 ALQAQLGEQTKLSREQIEGLI---------EDRRIHLEEIQVQHQRN-----------QN 234 + ++ EQ + REQ E + E++ EE+ + + + Sbjct: 318 EQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEE 377 Query: 235 KIKELTKNLHHTQELLYESTK----DFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCK 290 KI+EL + +H +++ + K + ++ + + Q +E +++ + + ++ R Q K Sbjct: 378 KIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEK 437 Query: 291 K---KEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKL----SNMYQEQCISLEEELA 343 K +E+KI + + E + E + ++K+ +++++ M++++ I +EE Sbjct: 438 KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKV 497 Query: 344 RIREEEGM--RREIFKDRTNKMGKRLQIMTKRYEAL--ERRRILEVEGFKTDIKVLRQKL 399 R+EE M + E +++ KM ++ + + ++ E + + +I E E ++ +K+ Sbjct: 498 -WRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEM---MQEQEEKM 553 Query: 400 KDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454 + E+ + + R + ++R+ + + + +++ + K++ E ++R Sbjct: 554 GEQEEKMQEQEKMRRQEE------KIREQEEKIREQKEKIREQEEKIWEQEEKIR 602 Score = 60.8 bits (146), Expect = 2e-09 Identities = 91/445 (20%), Positives = 204/445 (45%), Gaps = 75/445 (16%) Query: 24 KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQ 83 K+ Y ++ E +A + +L + +E E KL+ LQ E E +E+Q + +++ Sbjct: 189 KKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELK 248 Query: 84 VCLFQEREHVL----RLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCK---EPP 136 L ER +L +L +E D L K++Q++ A + E + + + Sbjct: 249 RKL--ERAKLLLPQQQLQAEADHL-------GKELQSVSAKLQAQVEENELWNRLNQQQE 299 Query: 137 HKVTILQKTIQAVGE-CEQSESSAFKADPKISKRRPSRERKE------------------ 177 K+ ++ IQ E ++ E + + KI ++ R+E Sbjct: 300 EKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMW 359 Query: 178 SSEHYQRDIQTLILQ----VEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQ--- 230 E R ++ ++ + + L+ ++ EQ K+ REQ E E+ +I +E + + + Sbjct: 360 EKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKI-REQEEKRQEEEKIREQEKRQEQEAKM 418 Query: 231 --------RNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSW-----MLEKDN 277 + KI+E K + +E ++E K ++ + Q +E+ W + E++ Sbjct: 419 WRQEEKIREQEEKIREQEKKMWRQEEKIHEQEK--IREEEKRQEQEEMWRQEEKIREQEE 476 Query: 278 LMSKIKQYRVQ--CKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKL-VQEKKLSNMYQEQ 334 + + ++ Q +K+E+K+ + E H Q E I+ ++K+ QE+K+ +EQ Sbjct: 477 IWRQKEKMHEQEKIRKQEEKVWR----QEEKMHDQEEKIREQEEKMWRQEEKI----REQ 528 Query: 335 CISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKV 394 + E+ +IRE+E E+ +++ KMG++ + M ++ + RR+ ++ + I+ Sbjct: 529 EEKIREQEEKIREQE----EMMQEQEEKMGEQEEKMQEQEKM--RRQEEKIREQEEKIRE 582 Query: 395 LRQKLKDLEQMLYKATVNARANQDL 419 ++K+++ E+ +++ R +++ Sbjct: 583 QKEKIREQEEKIWEQEEKIREQEEM 607 Score = 48.5 bits (114), Expect = 1e-05 Identities = 68/356 (19%), Positives = 157/356 (44%), Gaps = 54/356 (15%) Query: 24 KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQ 83 +E + ++ M E E + +L +K+ ++ E + K + + + RE+E + Q+A Q Sbjct: 362 EEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ 421 Query: 84 VCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQ 143 +E+E +R + + ++ +++KI+ Sbjct: 422 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIRE--------------------------- 454 Query: 144 KTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQ 203 E Q + ++ + KI ++ +KE H Q I+ +V + ++ +Q Sbjct: 455 ------EEKRQEQEEMWRQEEKIREQEEIWRQKEKM-HEQEKIRKQEEKVWRQEEKMHDQ 507 Query: 204 TKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSE 263 + REQ + ++ +E +++ Q + KI+E + + +E++ E + + + Sbjct: 508 EEKIREQ------EEKMWRQEEKIREQ--EEKIREQEEKIREQEEMMQEQEEKMGEQEEK 559 Query: 264 NQNKEKSWMLEKD--NLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKL 321 Q +EK E+ KI++ + + +++E+KI + E Q E ++ ++K+ Sbjct: 560 MQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWE----QEEKIREQEEMMQEQEEKM 615 Query: 322 -VQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEA 376 QE+K+ QE+ + +EE R +EE+ +E+ R + +++Q + EA Sbjct: 616 WEQEEKMCE--QEEKMQEQEEKMRRQEEKMWEQEV---RLRQQEEKMQEHQEHLEA 666 >gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sapiens] Length = 750 Score = 65.5 bits (158), Expect = 1e-10 Identities = 96/465 (20%), Positives = 204/465 (43%), Gaps = 72/465 (15%) Query: 12 SPEDRLAKLHPSKELLEYYQKKMAECEAENEDLL--KKLELYKEACEGQHKLECDLQQRE 69 SPED H +E L ++ E + +L +K EL QH ++ Q E Sbjct: 106 SPEDEQKASHQHQEAL----RRELEAQVHTIRILTCQKTELQMALYYSQHAVK----QLE 157 Query: 70 EEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVT 129 E +L L D E E L + + R +E+ K ++ L+L + T Sbjct: 158 GEARDLISRLHDSWK-FAGELEQALSAVATQKKKADRYIEELTKERDALSL---ELYRNT 213 Query: 130 YFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRR--------PSRERKESSEH 181 +E K LQ+ +Q V +SE S + + K KR+ P ++ + ++H Sbjct: 214 ITDEELKEKNAKLQEKLQLV----ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADH 269 Query: 182 YQRDIQTLILQVEALQAQLGEQTKLSREQIEGLI-EDRRIHLEEIQVQHQRN-----QNK 235 +++Q++ +++A + +L+++Q E + ++ +I E ++Q Q + K Sbjct: 270 LGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEK 329 Query: 236 IKELTKNLHHTQELLYESTK------DFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQC 289 I+E + + +E+++E + + + + E +++ M EK+ K+++ Sbjct: 330 IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE---KMRRQEEMM 386 Query: 290 KKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEE 349 +KE+KI ++ MHE + + K +++ ++E++ QEQ + + +IRE+E Sbjct: 387 WEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR---QEQEAKMWRQEEKIREQE 443 Query: 350 GMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKA 409 E +++ KM ++ + + E+ +I E E + ++ RQ+ K EQ Sbjct: 444 ----EKIREQEKKMWRQEE------KIHEQEKIREEEKRQEQEEMWRQEEKIHEQE---- 489 Query: 410 TVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454 E+ + H+ + +++ + KV+ E ++R Sbjct: 490 --------------EIWRQKEKMHEQEEKIRKQEEKVWRQEEKIR 520 Score = 57.4 bits (137), Expect = 3e-08 Identities = 81/388 (20%), Positives = 179/388 (46%), Gaps = 42/388 (10%) Query: 24 KELLEYYQKKMAECEAENEDLLKKLELYK-EACEGQHKLECDLQQREEEIAELQKALSDM 82 +E + ++KM E E E K+ E K E + + E + ++EE+I E ++ + + Sbjct: 390 EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 449 Query: 83 QVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTIL 142 + ++++ E + +++ +IRE E+K++ Q E + +E H+ + Sbjct: 450 EKKMWRQEEKI------HEQEKIRE-EEKRQEQ-----------EEMWRQEEKIHEQEEI 491 Query: 143 QKTIQAVGECEQS----ESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQA 198 + + + E E+ E ++ + KI R + +E E R + + Q E + Sbjct: 492 WRQKEKMHEQEEKIRKQEEKVWRQEEKI--REQEEKIREQEEKMWRQEEKIREQEEMWRE 549 Query: 199 Q--LGEQTKLSREQIEGLIEDRRIHLEE-IQVQHQ---RNQNKIKELTKNLHHTQELLYE 252 + + EQ K+ E+ ED+ EE I+ Q + R + KI+E + +E +++ Sbjct: 550 EEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWK 609 Query: 253 STKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSE 312 + + + Q +E+ +++ KI++ +++E+K+G+ M E E Sbjct: 610 QEEKIREQEEKIQEQEEKIREQEE----KIREQEEMTQEQEEKMGEQEEKMCEQEEKMQE 665 Query: 313 YIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTK 372 +++ QE+K+ +EQ + E+ +IRE+E M +E + + K + K Sbjct: 666 QEETMWR---QEEKI----REQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 718 Query: 373 RYEALERRRILEVEGFKTDIKVLRQKLK 400 E E+ R E + ++ ++++ +Q+ K Sbjct: 719 MQEQEEKMRRQEEKMWEQEVRLRQQEEK 746 Score = 49.7 bits (117), Expect = 6e-06 Identities = 61/333 (18%), Positives = 160/333 (48%), Gaps = 28/333 (8%) Query: 31 QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQER 90 ++K+ E E + + KK+ +E Q K+ + +++E+E Q+ Q +++++ Sbjct: 436 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQK 495 Query: 91 EHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVG 150 E +++ + +++R +E + ++ + + E +E K+ ++ I+ Sbjct: 496 E---KMHEQEEKIRKQEEKVWRQEEKIR--------EQEEKIREQEEKMWRQEEKIREQE 544 Query: 151 ECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQ 210 E + E + + KI + +E+++ + I+ +V + ++ EQ + +EQ Sbjct: 545 EMWREEEKMHEQE-KIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQ 603 Query: 211 IEGLI-EDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEK 269 E + ++ +I +E ++Q Q + KI+E + + +E+ E + + + E +++ Sbjct: 604 EEKMWKQEEKIREQEEKIQEQ--EEKIREQEEKIREQEEMTQEQEEKMGE-QEEKMCEQE 660 Query: 270 SWMLEKDNLM----SKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEK 325 M E++ M KI++ + +++E+KI + +M E Q E + ++K+ +++ Sbjct: 661 EKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQE----QEEKMWEQEEKMCEQE 716 Query: 326 KLSNMYQEQCISLEEEL----ARIREEEGMRRE 354 + +E+ EE++ R+R++E +E Sbjct: 717 EKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749 >gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like protein 6 [Homo sapiens] Length = 724 Score = 65.5 bits (158), Expect = 1e-10 Identities = 92/416 (22%), Positives = 194/416 (46%), Gaps = 55/416 (13%) Query: 14 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA 73 +++ AKL +E L+ + + +E + ++L +KLE + KL QQ + E Sbjct: 281 KEKNAKL---QEKLQLVESEKSEIQLNVKELKRKLE--------RAKLLLPQQQLQAEAD 329 Query: 74 ELQKALSDMQVCL---FQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTY 130 L K L + L +E E RL + + R+ E KIQ + ++ Sbjct: 330 HLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEE---KIQEWEEKIQEQEEKI-- 384 Query: 131 FCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLI 190 +E K+ ++ ++ E + + ++ + + R++ ++++ + Sbjct: 385 --REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK--- 439 Query: 191 LQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQ----RNQNKIKELTKNLHHT 246 + L+ ++ EQ K+ REQ E E+ +I +E + + + R + KI+E + + Sbjct: 440 --IRELEEKMHEQEKI-REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 496 Query: 247 QELLY---ESTKDFLQLRSENQNKEKSWML---EKDNLMSKIKQYRVQCKKKEDKIGKVL 300 +E ++ E + ++R E + +E+ M EK +I + + + ++E+KI K Sbjct: 497 EEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQE 556 Query: 301 PVM---HESHHAQSEYIKSLKDKLV-QEKKLSNMYQEQCISLEEELARIREEEGMRREIF 356 M E H Q E I+ ++K+ QE+K+ QE+ I +EE +IRE+E M +E Sbjct: 557 EKMWRQEEKMHDQEEKIREQEEKVWRQEEKIRE--QEEKIREQEE--KIREQEEMTQE-- 610 Query: 357 KDRTNKMGKRLQIMTKRYEALE------RRRILEVEGFKTDIKVLRQKLKDLEQML 406 + KMG++ + M ++ E ++ RR+ ++ + I+ +K+++ E+M+ Sbjct: 611 --QEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMM 664 Score = 64.7 bits (156), Expect = 2e-10 Identities = 75/387 (19%), Positives = 178/387 (45%), Gaps = 41/387 (10%) Query: 19 KLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKL----ECDLQQREEEIAE 74 K+ +E ++ +++K+ E E + + +K+ +E Q ++ E ++++EE + E Sbjct: 362 KMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 421 Query: 75 LQKALSDMQVCLFQEREHVLRLYSE-NDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCK 133 ++ + + ++++ E + L + +++ +IRE E+K++ + Sbjct: 422 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEE----------------- 464 Query: 134 EPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQV 193 K+ +K + + + E + + KI ++ R+E H Q I+ + Sbjct: 465 ----KIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQ 520 Query: 194 EALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYES 253 E Q ++ Q + REQ E + +IH +E +++ Q + K+ + +H +E + E Sbjct: 521 E--QEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQ--EEKMWRQEEKMHDQEEKIREQ 576 Query: 254 TKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEY 313 + R E + +E+ + + KI++ +++E+K+G+ M E E Sbjct: 577 EEKVW--RQEEKIREQEEKIREQE--EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQ 632 Query: 314 IKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKR 373 + ++ QE+K+ +EQ + E+ +IRE+E M +E + + K + K Sbjct: 633 EEKMRR---QEEKI----REQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKM 685 Query: 374 YEALERRRILEVEGFKTDIKVLRQKLK 400 E E+ R E + ++ ++++ +Q+ K Sbjct: 686 QEQEEKMRRQEEKMWEQEVRLRQQEEK 712 Score = 48.9 bits (115), Expect = 9e-06 Identities = 66/288 (22%), Positives = 125/288 (43%), Gaps = 55/288 (19%) Query: 171 PSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSR---------EQIEGLIED--RR 219 P E+K S +H + + L QV ++ ++T+L +Q+EG D R Sbjct: 168 PEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISR 227 Query: 220 IH------------LEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNK 267 +H L + Q ++ I+ELTK LY +T +L+ +N Sbjct: 228 LHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKL 287 Query: 268 EKSWML---EKDNLMSKIKQYR------------VQCKKKEDKIGKVLPVMHESHHAQSE 312 ++ L EK + +K+ + Q + + D +GK L + AQ E Sbjct: 288 QEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE 347 Query: 313 YIKSLKDKLVQEKKLSNMYQEQCI-----SLEEELARIRE--------EEGMRR--EIFK 357 L ++L Q+++ QE+ I ++E+ +IRE EE MRR E+ Sbjct: 348 E-NELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMW 406 Query: 358 DRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQM 405 ++ KM ++ ++M ++ E + R+ + E + I+ L +K+ + E++ Sbjct: 407 EKEEKMRRQEEMMWEKEEKMRRQEEMMWEK-EEKIRELEEKMHEQEKI 453 >gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] Length = 2230 Score = 65.5 bits (158), Expect = 1e-10 Identities = 94/437 (21%), Positives = 193/437 (44%), Gaps = 46/437 (10%) Query: 19 KLHPSKELLEYYQKKMAECEA-------ENEDLLKKLELYKEACEGQHKLECDLQQREEE 71 KL ++ E Y+ ++ E E+ EN++ K L ++ EA + +H E + E+ Sbjct: 554 KLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMV-EKH 612 Query: 72 IAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYF 131 EL+ +L Q L+ E+ VL+ + + ++RE +++K L + Sbjct: 613 KTELE-SLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEM 671 Query: 132 CKEPPHKVTILQKTIQAVG-ECEQSESSAFKADPKIS---------KRRPSRERKESSEH 181 ++ K+ + Q ++++ E + + K + ++S K+ + E H Sbjct: 672 NEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNH 731 Query: 182 YQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEE-------IQVQHQRNQN 234 +Q+ + ++I + E + + K Q+E L+++R HL+E ++ +R++ Sbjct: 732 HQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEG 791 Query: 235 KIKELTKNL---HHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQ--- 288 ++++ + L Q +E TK + + ++ Q K E+ L ++ + Q Sbjct: 792 ELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKD 851 Query: 289 -CKKKEDKIGKVLPVMHESHHAQSEYIKSLKD-KLVQEKKL--SNMYQEQC--ISLEEEL 342 C + + +V +M + SE + +K V E KL N QEQ I +E+E Sbjct: 852 VCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKEN 911 Query: 343 ARIREEEGMRREIFKDRTNKMGKR---LQIMTKRYEALERRRILEVEGFKTDIK----VL 395 ++ EG ++EI + T K+ + + I+ + YE + + ++E K K L Sbjct: 912 MILQMREGQKKEI-EILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETL 970 Query: 396 RQKLKDLEQMLYKATVN 412 ++KL D E L K N Sbjct: 971 KKKLLDQEAKLKKELEN 987 Score = 62.4 bits (150), Expect = 8e-10 Identities = 100/466 (21%), Positives = 192/466 (41%), Gaps = 66/466 (14%) Query: 10 LPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLE----LYKEACEGQ-HKLECD 64 L + EDRL +K L E +K + A + LL ++E YK+ E +L Sbjct: 1622 LKALEDRLESESAAK-LAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTK 1680 Query: 65 LQQREEEIAELQKAL-----SDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLA 119 LQ+RE E+ L++ L S + + + Y+E + + K + + Sbjct: 1681 LQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISV 1740 Query: 120 LVGTDAGEVTYFCKEPPHKVTILQKTIQAVG-ECEQSESSAFKADPKISKRRPSRERKES 178 L +T +K +Q VG E E++ SS F+ + +R E E+ Sbjct: 1741 L---------------QRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEA 1785 Query: 179 SEHYQRDI-------------QTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEI 225 +H + + + ++ + ++ + G+ +++ +E + +D + L+E Sbjct: 1786 KQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEK 1845 Query: 226 QVQHQRNQNKIKEL------TKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLM 279 ++ Q + KIKEL K +H + S + LQ + + K L ++N Sbjct: 1846 ELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTE 1905 Query: 280 SKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLE 339 K K + VQ K+L M H+ L+ KL ++ ++ + L+ Sbjct: 1906 EKSKSHLVQ--------PKLLSNMEAQHN-------DLEFKLAGAEREKQKLGKEIVRLQ 1950 Query: 340 EELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKV-LRQK 398 ++L +R+E EI K ++ +R + + + E LE + ++ + L QK Sbjct: 1951 KDLRMLRKEHQQELEILKKEYDQ--EREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQK 2008 Query: 399 LKDLEQMLYKATVNARANQDLALL-CEVRDSNRRAHKIQGELKNLK 443 ++LE M K T+N + LL ++N+ KI + +LK Sbjct: 2009 EQELE-MTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLK 2053 Score = 57.0 bits (136), Expect = 3e-08 Identities = 102/501 (20%), Positives = 208/501 (41%), Gaps = 60/501 (11%) Query: 2 ADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAE----NEDLLKKLELYKEACEG 57 + S ES S + L +L + + EAE N D L K +L + Sbjct: 87 SSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRM 146 Query: 58 QHKLECDLQQREEEIAE---LQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKI 114 + L + E + LQ+ +Q L Q ++ LR +E + + KK + Sbjct: 147 ERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHL 206 Query: 115 QN-----------LLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECE---QSESSAF 160 Q ++++ T + + P V +L+ Q + E + E+ Sbjct: 207 QEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPES 266 Query: 161 KADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLS--REQIEGLIEDR 218 +P + + + + +R L E +Q+ + T L+ +E ++ +++R Sbjct: 267 DGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDER 326 Query: 219 RIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKD-- 276 LE+I+ H + K+ ++ + E L E K + ++ Q E M E++ Sbjct: 327 LQELEKIKDLHMAEKTKLITQLRDAKNLIEQL-EQDKGMVIAETKRQMHETLEMKEEEIA 385 Query: 277 NLMSKIKQY-------RVQCKKKE----DKIGKVLPVMHESHHAQSEYIKSLKDKLVQEK 325 L S+IKQ R Q +K E +++ K L ++ A+ + +K+ D+ Q K Sbjct: 386 QLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRK-LKAEMDE--QIK 442 Query: 326 KLSNMYQEQCISLEEELARIREE---------EGMRREIFKDRTNKMGKRLQIMTKRYEA 376 + +E+ ISL++EL+R+++E E ++ K ++ ++ Q +TK+ + Sbjct: 443 TIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQT 502 Query: 377 LERRRILEVEGFKTDIKVLRQKLKD--LEQMLYKATVNARANQDLALLCE--VRDSNRRA 432 ER F+ +KV +K + L+ K + A ++L L + + +S + Sbjct: 503 RERE-------FQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKL 555 Query: 433 HKIQGELKNLKSKVFGLENEL 453 +Q E + ++++ LE+ L Sbjct: 556 RDLQQEAETYRTRILELESSL 576 Score = 54.7 bits (130), Expect = 2e-07 Identities = 95/468 (20%), Positives = 197/468 (42%), Gaps = 64/468 (13%) Query: 49 ELYKEACEGQHKLECDLQQREEEIAELQK----------------------------ALS 80 +L ++A E Q E LQ++E+E+AEL++ L+ Sbjct: 1050 KLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLN 1109 Query: 81 DMQVCLFQEREHVLRLYSENDRLR--IRELE-DKKKIQNLLALVGTDAGEVTYFCKEPPH 137 ++Q L Q+ HV L + +L+ + +LE D K + E+ +E Sbjct: 1110 ELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKR 1169 Query: 138 KVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEA-L 196 KV+ L ++ E QS S+ + K S S E K+ SE + + EA L Sbjct: 1170 KVSELTSKLKTTDEEFQSLKSSHEKSNK-SLEDKSLEFKKLSEELAIQLDICCKKTEALL 1228 Query: 197 QAQLGEQTKLSREQIEGLI------EDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELL 250 +A+ E +S + ++ + R ++E + ++++ + L Q L Sbjct: 1229 EAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTL 1288 Query: 251 YESTKDFLQLRSENQNKEKSW-------MLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVM 303 S + E +N+ KS + EK+ L + + +KE I ++ + Sbjct: 1289 NISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKEL 1348 Query: 304 HESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMR--REIFKDRTN 361 E+ +A + + LK+K V+ LS + + L+ ++ +E + R+ + + Sbjct: 1349 SENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKC 1408 Query: 362 KMGKRLQIMTKRYEALERRRIL---EVEGFKTDIKVLRQK-----------LKDLE-QML 406 ++ ++Q ++ + + L + +I +V+ + ++K +K+L+ Q+ Sbjct: 1409 ELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLE 1468 Query: 407 YKATVNARANQDLALLCEVRD-SNRRAHKIQGELKNLKSKVFGLENEL 453 K+ ++ + LL E D N+R ++GE+++ KSK+ E+ L Sbjct: 1469 LKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNL 1516 Score = 45.8 bits (107), Expect = 8e-05 Identities = 91/486 (18%), Positives = 195/486 (40%), Gaps = 69/486 (14%) Query: 14 EDRLAKLHPSKELLEYYQ----KKMAECEAENEDLLKKLELYK-EACEGQHKLECDLQQR 68 E++LA+L LE + K++AE EA+ +D+ +L+ +K + + +LE + Sbjct: 818 EEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEM 877 Query: 69 EEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELE-DKKKIQNLLALVGTDAGE 127 E+++ L + +E+E ++ E + + ++ E KK+I+ L + Sbjct: 878 EQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDS 937 Query: 128 VTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESS-EHYQRDI 186 + +E K +K ++ V + + K + + +E + ++ E Q++ Sbjct: 938 IHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEK 997 Query: 187 QTLILQVEALQAQ-LGEQTKLSR------EQIEGLIEDRRIHLEEIQVQHQRNQNKIKEL 239 Q +E QA G +SR EQIE L E R L ++ ++ N+ E Sbjct: 998 QFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEE 1057 Query: 240 TKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKV 299 + +H Q + EK+ ++++KQ + +++++ K Sbjct: 1058 LQEIHEIQ------------------------LQEKEQEVAELKQKILLFGCEKEEMNKE 1093 Query: 300 LPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIR------------- 346 + + E Q + L+++L Q+ N + L+ L ++ Sbjct: 1094 ITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFL 1153 Query: 347 ----EEEGMRREIFKDRTNKMGKRLQIMTKRYEALE---RRRILEVEGFKTDIKVLRQKL 399 E M E K + +++ +L+ + +++L+ + +E + K L ++L Sbjct: 1154 QEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEEL 1213 Query: 400 --------KDLEQMLYKAT---VNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFG 448 K E +L T +N +++ A+L + R K++ L V Sbjct: 1214 AIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSE 1273 Query: 449 LENELR 454 LE +LR Sbjct: 1274 LEAQLR 1279 Score = 41.2 bits (95), Expect = 0.002 Identities = 69/313 (22%), Positives = 135/313 (43%), Gaps = 45/313 (14%) Query: 174 ERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQ 233 E++ + + DI++L+ + EALQ + G Q + + E+ E I + L E N Sbjct: 1301 EKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEK-ESCITQLKKELSE-------NI 1352 Query: 234 NKIKELTKNLHHTQELLYESTKDFLQLRSENQNK-------------EKSWMLEKDNLMS 280 N + + + L + + +K L + QN K + EK L+ Sbjct: 1353 NAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLD 1412 Query: 281 KIK--QYRVQCKKKEDKIGKVLPVMHESH-------HAQSEY------IKSLKDKLVQEK 325 +++ ++V KE KI + V S+ AQS + +K L+ +L + Sbjct: 1413 QVQDLSFKVDTLSKE-KISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKS 1471 Query: 326 KLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEV 385 K + EQ L+EEL + + + +D +KM K+ + ++ + RI+E+ Sbjct: 1472 KEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKS-QTARIMEL 1530 Query: 386 EGFKT----DIKVLRQKLKDLEQMLYKATVNARANQDLALLCEV-RDSNRRAHKIQGELK 440 E T +I+ L + LK+ Q K + Q L E+ + + R + + ++ Sbjct: 1531 EDHITQKTIEIESLNEVLKNYNQQ--KDIEHKELVQKLQHFQELGEEKDNRVKEAEEKIL 1588 Query: 441 NLKSKVFGLENEL 453 L+++V+ ++ EL Sbjct: 1589 TLENQVYSMKAEL 1601 >gi|21735548 centrosomal protein 2 [Homo sapiens] Length = 2442 Score = 65.1 bits (157), Expect = 1e-10 Identities = 105/504 (20%), Positives = 215/504 (42%), Gaps = 88/504 (17%) Query: 14 EDRLAKLHPSKELLEYYQKKMAECEAENE-------DLLKKLELYKEACEGQHKLECDLQ 66 E ++A+ +E L + +AE E E E +L K+ E+ K A E L DL+ Sbjct: 1410 ELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALE---LLSLDLK 1466 Query: 67 QREEEIAELQKALSDMQVC---------LFQEREHVLRLYSENDRLRIRELE-DKKKIQN 116 +R +E+ Q+ + +++ C QERE L + E +IRELE D++ +N Sbjct: 1467 KRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQRE----QIRELEKDRETQRN 1522 Query: 117 LLA-----------LVGTDAGEV--------TYFC-----KEPPHKVTILQKTIQAVGEC 152 +L ++ + G+V T C +E HK+ QK I+ + Sbjct: 1523 VLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQ 1582 Query: 153 EQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIE 212 +++ A + R + +SS+ + + + +L E + ++ K REQIE Sbjct: 1583 RETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERD--QEVKSQREQIE 1640 Query: 213 GLIEDRR--------------IHLEEIQVQHQRNQNKIKELTKNLHHTQELLYE------ 252 L + + E IQV + + K L ++L + L E Sbjct: 1641 ELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELT 1700 Query: 253 STKDFLQLRSEN---QNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHA 309 + + +Q R+E +K + LE L+ + K+ V+C+++ + + E Sbjct: 1701 TQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEH------IHELQELKDQ 1754 Query: 310 QSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQI 369 + ++ L K+ + L + +++ + L+++L RE+ ++ + + + ++ + L Sbjct: 1755 LEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQ 1814 Query: 370 MTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSN 429 + EAL++ + + +G + +K +K L+ L +A + + E++D Sbjct: 1815 RDQELEALQQEQ-QQAQGQEERVK---EKADALQGALEQAHMTLKERHG-----ELQDHK 1865 Query: 430 RRAHKIQGELKNLKSKVFGLENEL 453 +A +++ EL +V LE L Sbjct: 1866 EQARRLEEELAVEGRRVQALEEVL 1889 Score = 57.0 bits (136), Expect = 3e-08 Identities = 94/486 (19%), Positives = 212/486 (43%), Gaps = 54/486 (11%) Query: 18 AKLHPSKELLEYYQKKMAECEAENEDLLKK---LELY-KEACEGQHKLECDLQQREEEIA 73 +++ +++ Q +AE E E L +K LE ++A E +L+ DL+ +EE Sbjct: 631 SRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKE 690 Query: 74 ELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAG-EVTYFC 132 E+QK LS+ + Q+ +L + + +E + +Q ALV A EV Sbjct: 691 EIQKKLSESR---HQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQA 747 Query: 133 KEPPHKVTILQKTIQAVGECEQS-ESSAFKADPKISKRRPSRERKE--------SSEHYQ 183 E + L + +Q + ++ ESS F+A + S ++ + E + E Q Sbjct: 748 VERDRQD--LAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQ 805 Query: 184 RDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKEL--TK 241 +++ L L+++ ++Q ++ + Q+ ++ + LE+ + H++ N+++E + Sbjct: 806 GEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKE 865 Query: 242 NLHHTQELL-----YESTKDFLQLRSENQNKEKSWML-----EKDNLMSKIKQYRVQCKK 291 H QEL E K L++R + Q E + E+ S + Q +++ +K Sbjct: 866 RSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEK 925 Query: 292 KEDKIGKVLPVMHESHHAQSEYIKSLKDKL----VQEKKLSNMYQEQCISLEEELARIRE 347 + + + L + S+ ++ L+ + ++E++ + + Q Q + EL Sbjct: 926 ERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAAR 985 Query: 348 EEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKL-------- 399 + ++ ++ + + + K+ E L+ + + + + + + +++KL Sbjct: 986 QHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNR 1045 Query: 400 --KDLEQMLYKATVNARANQDLALLCEVRDSNRR---------AHKIQGELKNLKSKVFG 448 K+LE+ T++ + L+ + DS R+ + QGE K L +++ Sbjct: 1046 IQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMEL 1105 Query: 449 LENELR 454 L E++ Sbjct: 1106 LRQEVK 1111 Score = 47.4 bits (111), Expect = 3e-05 Identities = 87/447 (19%), Positives = 187/447 (41%), Gaps = 53/447 (11%) Query: 1 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKL-ELYKEACEGQH 59 M + E PS R + H +L+ ++K EC+ E+ L++L + ++ +G H Sbjct: 1706 MQERAEEGKGPSKAQRGSLEH--MKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLH 1763 Query: 60 KLECD----LQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQ 115 + + L QRE+EI LQ+ L + + + L+ S +L + ++ Q Sbjct: 1764 RKVGETSLLLSQREQEIVVLQQQLQEAR------EQGELKEQSLQSQLDEAQRALAQRDQ 1817 Query: 116 NLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRER 175 L AL + + + +K G EQ+ + + ++ ++ Sbjct: 1818 ELEALQQEQQ-------QAQGQEERVKEKADALQGALEQAHMTLKERHGEL------QDH 1864 Query: 176 KESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNK 235 KE + + ++ +V+AL+ LG+ SREQ + L+ + ++ Q Q ++ + Sbjct: 1865 KEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQ----QQCAEQAQEHEVE 1920 Query: 236 IKELTKNLHHTQELLYESTKDFLQLRSENQ---NKEKSWMLEKDNLMSKIKQYRVQCKKK 292 + L + Q +L E ++ LR+E+Q ++E++ + L + + + K Sbjct: 1921 TRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGK 1980 Query: 293 EDKIGKVLPVMH----------------ESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCI 336 E + + + ++H Q E +++ +Q++ L YQE Sbjct: 1981 EQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDL--RYQEDVQ 2038 Query: 337 SLEEELARIREEEGMRREIFKDRTNKMGKRLQ--IMTKRYEALERRRILEVEGFKTDIKV 394 L++ LA+ EE ++E + + +R+Q ++ ++ + R E+ G ++ Sbjct: 2039 QLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRE 2098 Query: 395 LRQKLKDLEQMLYKATVNARANQDLAL 421 L+ L EQ + + + N AL Sbjct: 2099 LQLTLAQKEQEILELRETQQRNNLEAL 2125 Score = 46.6 bits (109), Expect = 5e-05 Identities = 107/523 (20%), Positives = 214/523 (40%), Gaps = 83/523 (15%) Query: 14 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQH-----------KLE 62 E++ +LH + E Q+ + EA+ + L +L +EA E H ++ Sbjct: 508 EEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVT 567 Query: 63 CDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKI-----QNL 117 L + E+ IAEL + + ++ + R ++L + N+ L + ++ +++ +N Sbjct: 568 AALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQ 627 Query: 118 LALVGTDAGEVTY------FCKEPPHKVTILQKTIQAVGECEQSESSA--FKADPK-ISK 168 +A E + + + +K + +++E + +AD + I + Sbjct: 628 SVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQE 687 Query: 169 RRPSRERKESSEHYQRDIQTLIL---------QVEALQAQLGEQTKLSRE------QIEG 213 + ++K S +Q++ T L Q E L + E+ L RE +++ Sbjct: 688 EKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQA 747 Query: 214 LIEDRRIHLEEIQ------------VQHQRNQNKIKELTKNLHHTQELLYESTKDFLQ-- 259 + DR+ E++Q + + QN + E+TK Q K+ +Q Sbjct: 748 VERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGE 807 Query: 260 ---LRSENQNKEKSWMLEKDNLMSKIKQYR-------VQCKKKEDKIGKVLPVMHESHHA 309 L+ E + E+D ++ Q Q K +K L E + Sbjct: 808 VRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERS 867 Query: 310 --QSEYIKSL----KDKLVQEKKLSNMYQE-QCISLEEELARIREEEG---MRREIFKDR 359 Q E K+L ++K+ E +L E + I + E R + E M+ E K+R Sbjct: 868 WHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKER 927 Query: 360 TNKMGKRLQIMTKRYEA---LER-RRILEVEGFKTD--IKVLRQKLKDLEQMLYKATVNA 413 + + LQ + +A LER R+ ++V+ K +L+ +L++ ++ L +A Sbjct: 928 VSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQH 987 Query: 414 RANQDLALLCEVRDS-NRRAHKIQGELKNLKSKVFGLENELRL 455 R DLA L E S + +Q ++++LKS++ ++ RL Sbjct: 988 R--DDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRL 1028 Score = 42.7 bits (99), Expect = 7e-04 Identities = 71/328 (21%), Positives = 135/328 (41%), Gaps = 32/328 (9%) Query: 29 YYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQ 88 ++Q+++A+ E +K+EL E Q ++E QREEE + + AL MQ+ Sbjct: 868 WHQQELAKALESLER--EKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQL---- 921 Query: 89 EREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQA 148 E ++ R+ LE + Q LA DA + ++ + ++ Sbjct: 922 ----------ETEKERVSLLETLLQTQKELA----DASQQLERLRQDMKVQKLKEQETTG 967 Query: 149 VGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSR 208 + + + E+ + R +E S +D L QVE L++QL Q R Sbjct: 968 ILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQR 1027 Query: 209 EQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFL---QLRSENQ 265 + + E R E ++Q + + K + Q LL D + +L + Q Sbjct: 1028 LVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQ 1087 Query: 266 NKEKSWMLEKDNLMSKIKQYRVQCKKKEDKI----GKVLPVMHESHHAQSEYIKSLKDKL 321 + +++ E+ L ++++ R + K+KE ++L + SH + + SL Sbjct: 1088 DMQEA-QGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASL---W 1143 Query: 322 VQEKKLSNMYQEQCISLEEELARIREEE 349 QE K + + Q + S E +L + E+ Sbjct: 1144 AQEAKAAQL-QLRLRSTESQLEALAAEQ 1170 Score = 41.6 bits (96), Expect = 0.002 Identities = 101/515 (19%), Positives = 209/515 (40%), Gaps = 93/515 (18%) Query: 10 LPSPEDRLAKLHPSKEL----LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDL 65 L E RL L + + L ++ M E + E ++L ++EL ++ + + E D Sbjct: 1061 LMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEK---EADF 1117 Query: 66 QQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDA 125 +E A+L + L + Q R + ++ +L++R + +++ L A Sbjct: 1118 LAQE---AQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAA--EQQP 1172 Query: 126 GEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRD 185 G + + LQ+ + +V E S + P + P + S ++R Sbjct: 1173 GNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSL--FKRG 1230 Query: 186 IQTLILQVEALQAQLG---------EQTK-LSREQIEGL--------IEDRRIH--LEEI 225 L EA+ + L +QT+ + R+Q++ L E ++H L+++ Sbjct: 1231 PLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDL 1290 Query: 226 QVQHQRNQ----------NKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEK 275 Q Q +NQ N ++ LH T L + R E Q + + K Sbjct: 1291 QRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAK 1350 Query: 276 DNLMSKIKQYR---VQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQ 332 +NL ++++ + V+ + + G ++ E +K +++ E++ + Q Sbjct: 1351 ENLTAQVEHLQAAVVEARAQASAAG----ILEEDLRTARSALKLKNEEVESERERAQALQ 1406 Query: 333 E-------QCISLEEELARI------REEE-----GMRREIFKDR-------------TN 361 E Q +L+E LA + REEE G +E+ K R Sbjct: 1407 EQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLK 1466 Query: 362 KMGKRLQIMTKRYEALER-RRILE-----VEGFKTDIKVLRQKLKDLEQMLYKATVNARA 415 K + + + ++ + LE+ R +LE V+ + + V R+++++LE+ + N Sbjct: 1467 KRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKD-RETQRNVLE 1525 Query: 416 NQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLE 450 +Q L E+ ++ +G++++LK ++ LE Sbjct: 1526 HQ----LLELEKKDQMIESQRGQVQDLKKQLVTLE 1556 Score = 35.0 bits (79), Expect = 0.14 Identities = 87/464 (18%), Positives = 173/464 (37%), Gaps = 75/464 (16%) Query: 38 EAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLY 97 E ++LL +LE ++ CE ++ L+ E+ + KAL RE V +L Sbjct: 93 EPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKAL----------REDVEKLT 142 Query: 98 SE----NDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPP----HKVTILQKT---- 145 + D L +E + + + + + + G + +E H + + T Sbjct: 143 VDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDL 202 Query: 146 IQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTK 205 ++ E + S +++ SRE S R+ L+L + Q E + Sbjct: 203 MELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHE 262 Query: 206 LSREQIE---------GLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKD 256 S+E I+ ++DR L + Q Q+ +++ K L T E+L + + Sbjct: 263 RSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTE 322 Query: 257 FLQLRSENQNKEKSWMLEKDNLMSKIKQYRV-------QCKKKEDKI------------- 296 ++ + + L ++ I Q V Q E+ + Sbjct: 323 LMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQ 382 Query: 297 --GKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGM--- 351 K L ++ + + ++ L+ +L ++ N+ Q+Q EEE +R+ Sbjct: 383 DADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTG 442 Query: 352 RREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATV 411 R+ +T + + ++K E L++ R + LRQ+L+ LEQ ++ Sbjct: 443 ERDTLAGQTVDLQGEVDSLSKERELLQKAR-----------EELRQQLEVLEQEAWRL-- 489 Query: 412 NARANQDLAL-----LCEVRDSNRRAHKIQGELKNLKSKVFGLE 450 R N +L L + + H E + L+ + GLE Sbjct: 490 -RRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLE 532 >gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapiens] Length = 436 Score = 65.1 bits (157), Expect = 1e-10 Identities = 65/346 (18%), Positives = 161/346 (46%), Gaps = 26/346 (7%) Query: 40 ENEDLLKKLELYKEACEGQ-HKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYS 98 E E +++ E EGQ + E ++++E ++ E + + + + Q RE ++ Sbjct: 112 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG---QVREQEGQVRE 168 Query: 99 ENDRLRIRE---LEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQS 155 + ++R +E E + +++ +G G++ ++ + +QK + +GE E+ Sbjct: 169 QEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQ 228 Query: 156 ESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLI 215 + E++E + + +Q Q+ + Q+ EQ + REQ E ++ Sbjct: 229 MRK---------QEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQML 279 Query: 216 EDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEK 275 + + +E Q Q Q ++E + + +E + E + + + E K++ M E+ Sbjct: 280 KQKEQTEQEEQTGEQEEQ--MREQEEQMREQEEQMREQEEQMRE-QEEQMGKQEEQMWEQ 336 Query: 276 DNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQC 335 M + K+ Q K+E+++G+ E Q E ++ ++++ ++++ +EQ Sbjct: 337 KEQMWEQKE---QMWKQEEQMGE----QEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQM 389 Query: 336 ISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRR 381 EE++ +E+ G ++E +++ +MG++ + M K+ E + ++ Sbjct: 390 RKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQK 435 Score = 37.4 bits (85), Expect = 0.028 Identities = 40/213 (18%), Positives = 99/213 (46%), Gaps = 11/213 (5%) Query: 169 RRPSRERKESSEHYQRDIQTLILQVEALQAQLGE-QTKLSREQIEGLIEDRRIHLEEIQV 227 R + E KE + Q ++Q + + +Q + E + KL ++I L ++ ++ +E QV Sbjct: 3 RITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIP-LPQEGQVREQEGQV 61 Query: 228 QHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRV 287 + Q Q ++E + + + E + E Q +E+ + + ++++ Sbjct: 62 REQEGQ--VREQEGQVREQEGQVREQEGQVRE--QEGQVREQEGQVREQE--GQVREQEG 115 Query: 288 QCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIRE 347 Q +++E ++ + + E E ++++ Q ++ +EQ + E+ ++RE Sbjct: 116 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 175 Query: 348 EEGMRRE---IFKDRTNKMGKRLQIMTKRYEAL 377 +EG RE +++ +MG++ M ++ E + Sbjct: 176 QEGQVREQEGQVREQEGQMGEQEGQMGEQEEQM 208 >gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sapiens] Length = 1843 Score = 63.9 bits (154), Expect = 3e-10 Identities = 101/479 (21%), Positives = 206/479 (43%), Gaps = 67/479 (13%) Query: 14 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA 73 + ++ L + E +E +++ +E E EN L K L+ +K LE + Q +EE Sbjct: 645 QKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENL 704 Query: 74 ELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLA-LVGTDAGEVTYFC 132 EL++ + ++ + + +L EN L + + KK ++ L A T+ EV+Y Sbjct: 705 ELRRNVESLKCASMK----MAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQG 760 Query: 133 KEPPHKVTILQKTI--------QAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQR 184 + ++ LQKT+ Q E + E + + + S +R E E + Sbjct: 761 LDIENQ--RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENK 818 Query: 185 DIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLH 244 ++ Q+E + QL ++ K R+Q E I+D + +++ + +N K L+K + Sbjct: 819 SLEQETSQLEKDKKQLEKENKRLRQQAE--IKDTTLEENNVKIGNLEKEN--KTLSKEI- 873 Query: 245 HTQELLYESTKDFLQLRSENQNKEKSWMLE-------KDNLMS---KIKQYRVQCKKKED 294 + ES +L EN+ K ++ +++L+S K +Q +K Sbjct: 874 ---GIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH 930 Query: 295 KIGKV----LPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEG 350 ++ K+ ++H+ K L+ KL K S +E+ I+ E AR+ E Sbjct: 931 ELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALE--ARLEESTN 988 Query: 351 MRREIFKDRTNKMGKRLQIMTKRYEALERRR-----------------ILEVEGFKTDIK 393 +++ ++ L+ + K YEAL++R+ E E +T + Sbjct: 989 YNQQLRQE--------LKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRE 1040 Query: 394 VLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 452 +L+ K + +E AT+ A + AL +++ + + +Q ++ L+ + L+ + Sbjct: 1041 LLKVKDRLIEVERNNATLQA---EKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ 1096 Score = 63.5 bits (153), Expect = 4e-10 Identities = 112/489 (22%), Positives = 204/489 (41%), Gaps = 89/489 (18%) Query: 27 LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCL 86 +E+Y+ ++ E + +N+ LL+ + ++ EG L + E+E +L+ L DM++ Sbjct: 339 IEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMER 398 Query: 87 FQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEV--TYFCKEPP-----HKV 139 +R+ + L EN L E+ K+ + L L G + ++ T E P H+V Sbjct: 399 DMDRKKIEELMEENMTL---EMAQKQSMDESLHL-GWELEQISRTSELSEAPQKSLGHEV 454 Query: 140 TIL------------QKTIQAVGECEQSESSAFKADPKISKRRPSRER------------ 175 L Q + V E + S KI K +R Sbjct: 455 NELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEI 514 Query: 176 ---KESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEE-IQVQHQR 231 K+S ++ Q + L+ + L+ + + S QI+ ++E HL + + QR Sbjct: 515 VQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIK-ILEQENEHLNQTVSSLRQR 573 Query: 232 NQNKIKELTKNLHHTQELLYESTKDF-----------LQLRSENQN-KEKS--------- 270 +Q + K++ ++L+ES K+ Q++ E ++ KEK Sbjct: 574 SQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENE 633 Query: 271 -WMLEKDN--LMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKL 327 LEK+N L KI ++ C+K E + + + + LK L K L Sbjct: 634 LHHLEKENELLQKKITNLKITCEKIE--------ALEQENSELERENRKLKKTLDSFKNL 685 Query: 328 SNMYQEQCISLEEELARIREEE-GMRR--EIFKDRTNKMGKRLQIMTKRYEALERRRILE 384 + Q SLE+E +++ EE +RR E K + KM +LQ+ K E+ E Sbjct: 686 T----FQLESLEKENSQLDEENLELRRNVESLKCASMKMA-QLQLENKELES-------E 733 Query: 385 VEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKS 444 E K +++L+ K E++ NQ L E +SN++ +++ EL++L+ Sbjct: 734 KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLE--NSNKKIQQLESELQDLEM 791 Query: 445 KVFGLENEL 453 + L+ L Sbjct: 792 ENQTLQKNL 800 Score = 63.5 bits (153), Expect = 4e-10 Identities = 97/449 (21%), Positives = 197/449 (43%), Gaps = 57/449 (12%) Query: 25 ELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQV 84 E ++ K+++ E E + K+LE YKE E +LE +L E+E LQK ++++++ Sbjct: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKI 653 Query: 85 CLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQK 144 E + L EN L + KK + + K ++ L+K Sbjct: 654 TC----EKIEALEQENSELERENRKLKKTLDSF---------------KNLTFQLESLEK 694 Query: 145 TIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQT 204 + E E E K + + ++ + E+ E + + + L +E L+A ++T Sbjct: 695 ENSQLDE-ENLELRRNVESLKCASMKMAQLQLENKE-LESEKEQLKKGLELLKASF-KKT 751 Query: 205 KLSREQIEGL-IEDRRIH--LEEIQVQHQRNQNKIKEL---TKNLHHTQELLYESTKDFL 258 + +GL IE++R+ LE + Q+ ++++++L + L E L S+K Sbjct: 752 ERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE 811 Query: 259 QLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLK 318 QL EN++ E+ S++++ + Q +K+ ++ + + + + I +L+ Sbjct: 812 QLEKENKSLEQE--------TSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE 863 Query: 319 DKLVQEKKLSNMYQEQCISLEE------ELAR-----IREEEGMRREIFKD--RTNKMGK 365 + K +Y+E C+ L+E EL + I+ +R ++ + +T +M Sbjct: 864 KENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNN 923 Query: 366 RLQIMTKRYE--ALERRRILEVEGFKTD--IKVLRQKLKDLEQMLYKATVNARANQDLAL 421 L+ +T E L + R+L E D K+L KL + K ++ + + AL Sbjct: 924 DLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKL----ESTLKKSLEIKEEKIAAL 979 Query: 422 LCEVRDSNRRAHKIQGELKNLKSKVFGLE 450 + +S +++ ELK +K L+ Sbjct: 980 EARLEESTNYNQQLRQELKTVKKNYEALK 1008 Score = 47.0 bits (110), Expect = 4e-05 Identities = 88/434 (20%), Positives = 177/434 (40%), Gaps = 62/434 (14%) Query: 25 ELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQV 84 E+ E ++ + E EN+ L K +E + + + + E+E L K + ++ Sbjct: 453 EVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN 512 Query: 85 CLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQK 144 + QE++ + + QNL K+ + L+K Sbjct: 513 EIVQEKQSL------------------QNCQNL--------------SKDLMKEKAQLEK 540 Query: 145 TIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQT 204 TI+ + E + + + + + + S R+ S Q + + +E L E Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRS----QISAEARVKDIEKENKILHESI 596 Query: 205 KLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSEN 264 K + ++ + ++R +E++ ++ + +EL LHH E + LQ + N Sbjct: 597 KETSSKLSKIEFEKRQIKKELE-HYKEKGERAEELENELHH-----LEKENELLQKKITN 650 Query: 265 Q--NKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKL- 321 EK LE++N S++++ + KK D K L ES ++ + +L Sbjct: 651 LKITCEKIEALEQEN--SELERENRKLKKTLDSF-KNLTFQLESLEKENSQLDEENLELR 707 Query: 322 --VQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALER 379 V+ K ++M Q +EL +E+ E+ K + K +RL++ + + + Sbjct: 708 RNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLK-ASFKKTERLEVSYQGLDIENQ 766 Query: 380 RRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLAL-LCEVRDSNRRAHKIQGE 438 R +E I+ L +L+DLE NQ L L E++ S++R +++ E Sbjct: 767 RLQKTLENSNKKIQQLESELQDLEM----------ENQTLQKNLEELKISSKRLEQLEKE 816 Query: 439 LKNLKSKVFGLENE 452 K+L+ + LE + Sbjct: 817 NKSLEQETSQLEKD 830 Score = 41.2 bits (95), Expect = 0.002 Identities = 74/337 (21%), Positives = 127/337 (37%), Gaps = 65/337 (19%) Query: 6 ESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDL 65 E L S D L K H ELL Q +E E L+ K K A + DL Sbjct: 1145 EREDLKSLYDSLIKDHEKLELLHERQA------SEYESLISKHGTLKSAHKNLEVEHRDL 1198 Query: 66 QQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDA 125 + R ++ + + L D++ L E+E +L LE+K T A Sbjct: 1199 EDRYNQLLKQKGQLEDLEKMLKVEQEKML-------------LENKNH--------ETVA 1237 Query: 126 GEVTYFCKEPP---HKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHY 182 E C E H + L K + + + + + + K+ + R E + E Y Sbjct: 1238 AEYKKLCGENDRLNHTYSQLLKETEVL-QTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQY 1296 Query: 183 QRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKN 242 Q Q++ +L Q +L Q++G +E+ HL + Q+Q QN+ Sbjct: 1297 Q--------QLDITSTKLNNQCEL-LSQLKGNLEEENRHLLD-QIQTLMLQNR------- 1339 Query: 243 LHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPV 302 L +N + + +E+ + K+ + R Q +K E+KI Sbjct: 1340 ----------------TLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKF 1383 Query: 303 MHES-HHAQSEYIKSLKDKLVQEKKLSNMYQEQCISL 338 S + +I KL++ KK N +++ ++L Sbjct: 1384 YDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTL 1420 >gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo sapiens] Length = 1870 Score = 63.9 bits (154), Expect = 3e-10 Identities = 97/448 (21%), Positives = 197/448 (43%), Gaps = 56/448 (12%) Query: 25 ELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQV 84 E ++ K+++ E E + K+LE YKE E +LE +L E+E LQK ++++++ Sbjct: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKI 653 Query: 85 CLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQK 144 E + L EN L + KK + + K ++ L+K Sbjct: 654 TC----EKIEALEQENSELERENRKLKKTLDSF---------------KNLTFQLESLEK 694 Query: 145 TIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQT 204 + E E E K + + ++ + E+ E + + + L +E L+A ++T Sbjct: 695 ENSQLDE-ENLELRRNVESLKCASMKMAQLQLENKE-LESEKEQLKKGLELLKASF-KKT 751 Query: 205 KLSREQIEGL-IEDRRIH--LEEIQVQHQRNQNKIKEL---TKNLHHTQELLYESTKDFL 258 + +GL IE++R+ LE + Q+ ++++++L + L E L S+K Sbjct: 752 ERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE 811 Query: 259 QLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLK 318 QL EN++ E+ S++++ + Q +K+ ++ + + + + I +L+ Sbjct: 812 QLEKENKSLEQE--------TSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE 863 Query: 319 DKLVQEKKLSNMYQEQCISLEE------ELAR-----IREEEGMRREIFKD--RTNKMGK 365 + K +Y+E C+ L+E EL + I+ +R ++ + +T +M Sbjct: 864 KENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNN 923 Query: 366 RLQIMTKRYE--ALERRRILEVEGFKTD-IKVLRQKLKDLEQMLYKATVNARANQDLALL 422 L+ +T E L + R+L E D K+L KL + K ++ + + AL Sbjct: 924 DLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKL----ESTLKKSLEIKEEKIAALE 979 Query: 423 CEVRDSNRRAHKIQGELKNLKSKVFGLE 450 + +S +++ ELK +K L+ Sbjct: 980 ARLEESTNYNQQLRQELKTVKKNYEALK 1007 Score = 63.5 bits (153), Expect = 4e-10 Identities = 112/489 (22%), Positives = 204/489 (41%), Gaps = 89/489 (18%) Query: 27 LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCL 86 +E+Y+ ++ E + +N+ LL+ + ++ EG L + E+E +L+ L DM++ Sbjct: 339 IEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMER 398 Query: 87 FQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEV--TYFCKEPP-----HKV 139 +R+ + L EN L E+ K+ + L L G + ++ T E P H+V Sbjct: 399 DMDRKKIEELMEENMTL---EMAQKQSMDESLHL-GWELEQISRTSELSEAPQKSLGHEV 454 Query: 140 TIL------------QKTIQAVGECEQSESSAFKADPKISKRRPSRER------------ 175 L Q + V E + S KI K +R Sbjct: 455 NELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEI 514 Query: 176 ---KESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEE-IQVQHQR 231 K+S ++ Q + L+ + L+ + + S QI+ ++E HL + + QR Sbjct: 515 VQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIK-ILEQENEHLNQTVSSLRQR 573 Query: 232 NQNKIKELTKNLHHTQELLYESTKDF-----------LQLRSENQN-KEKS--------- 270 +Q + K++ ++L+ES K+ Q++ E ++ KEK Sbjct: 574 SQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENE 633 Query: 271 -WMLEKDN--LMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKL 327 LEK+N L KI ++ C+K E + + + + LK L K L Sbjct: 634 LHHLEKENELLQKKITNLKITCEKIE--------ALEQENSELERENRKLKKTLDSFKNL 685 Query: 328 SNMYQEQCISLEEELARIREEE-GMRR--EIFKDRTNKMGKRLQIMTKRYEALERRRILE 384 + Q SLE+E +++ EE +RR E K + KM +LQ+ K E+ E Sbjct: 686 T----FQLESLEKENSQLDEENLELRRNVESLKCASMKMA-QLQLENKELES-------E 733 Query: 385 VEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKS 444 E K +++L+ K E++ NQ L E +SN++ +++ EL++L+ Sbjct: 734 KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLE--NSNKKIQQLESELQDLEM 791 Query: 445 KVFGLENEL 453 + L+ L Sbjct: 792 ENQTLQKNL 800 Score = 63.2 bits (152), Expect = 5e-10 Identities = 102/479 (21%), Positives = 207/479 (43%), Gaps = 68/479 (14%) Query: 14 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA 73 + ++ L + E +E +++ +E E EN L K L+ +K LE + Q +EE Sbjct: 645 QKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENL 704 Query: 74 ELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLA-LVGTDAGEVTYFC 132 EL++ + ++ + + +L EN L + + KK ++ L A T+ EV+Y Sbjct: 705 ELRRNVESLKCASMK----MAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQG 760 Query: 133 KEPPHKVTILQKTI--------QAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQR 184 + ++ LQKT+ Q E + E + + + S +R E E + Sbjct: 761 LDIENQ--RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENK 818 Query: 185 DIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLH 244 ++ Q+E + QL ++ K R+Q E I+D + +++ + +N K L+K + Sbjct: 819 SLEQETSQLEKDKKQLEKENKRLRQQAE--IKDTTLEENNVKIGNLEKEN--KTLSKEI- 873 Query: 245 HTQELLYESTKDFLQLRSENQNKEKSWMLE-------KDNLMS---KIKQYRVQCKKKED 294 + ES +L EN+ K ++ +++L+S K +Q +K Sbjct: 874 ---GIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH 930 Query: 295 KIGKV----LPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEG 350 ++ K+ ++H+ Y K L+ KL K S +E+ I+ E AR+ E Sbjct: 931 ELEKIGLNKERLLHDEQSTDDRY-KLLESKLESTLKKSLEIKEEKIAALE--ARLEESTN 987 Query: 351 MRREIFKDRTNKMGKRLQIMTKRYEALERRR-----------------ILEVEGFKTDIK 393 +++ ++ L+ + K YEAL++R+ E E +T + Sbjct: 988 YNQQLRQE--------LKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRE 1039 Query: 394 VLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 452 +L+ K + +E AT+ A + AL +++ + + +Q ++ L+ + L+ + Sbjct: 1040 LLKVKDRLIEVERNNATLQA---EKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ 1095 Score = 47.0 bits (110), Expect = 4e-05 Identities = 88/434 (20%), Positives = 177/434 (40%), Gaps = 62/434 (14%) Query: 25 ELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQV 84 E+ E ++ + E EN+ L K +E + + + + E+E L K + ++ Sbjct: 453 EVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN 512 Query: 85 CLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQK 144 + QE++ + + QNL K+ + L+K Sbjct: 513 EIVQEKQSL------------------QNCQNL--------------SKDLMKEKAQLEK 540 Query: 145 TIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQT 204 TI+ + E + + + + + + S R+ S Q + + +E L E Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRS----QISAEARVKDIEKENKILHESI 596 Query: 205 KLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSEN 264 K + ++ + ++R +E++ ++ + +EL LHH E + LQ + N Sbjct: 597 KETSSKLSKIEFEKRQIKKELE-HYKEKGERAEELENELHH-----LEKENELLQKKITN 650 Query: 265 Q--NKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKL- 321 EK LE++N S++++ + KK D K L ES ++ + +L Sbjct: 651 LKITCEKIEALEQEN--SELERENRKLKKTLDSF-KNLTFQLESLEKENSQLDEENLELR 707 Query: 322 --VQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALER 379 V+ K ++M Q +EL +E+ E+ K + K +RL++ + + + Sbjct: 708 RNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLK-ASFKKTERLEVSYQGLDIENQ 766 Query: 380 RRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLAL-LCEVRDSNRRAHKIQGE 438 R +E I+ L +L+DLE NQ L L E++ S++R +++ E Sbjct: 767 RLQKTLENSNKKIQQLESELQDLEM----------ENQTLQKNLEELKISSKRLEQLEKE 816 Query: 439 LKNLKSKVFGLENE 452 K+L+ + LE + Sbjct: 817 NKSLEQETSQLEKD 830 Score = 41.2 bits (95), Expect = 0.002 Identities = 74/337 (21%), Positives = 127/337 (37%), Gaps = 65/337 (19%) Query: 6 ESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDL 65 E L S D L K H ELL Q +E E L+ K K A + DL Sbjct: 1144 EREDLKSLYDSLIKDHEKLELLHERQA------SEYESLISKHGTLKSAHKNLEVEHRDL 1197 Query: 66 QQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDA 125 + R ++ + + L D++ L E+E +L LE+K T A Sbjct: 1198 EDRYNQLLKQKGQLEDLEKMLKVEQEKML-------------LENKNH--------ETVA 1236 Query: 126 GEVTYFCKEPP---HKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHY 182 E C E H + L K + + + + + + K+ + R E + E Y Sbjct: 1237 AEYKKLCGENDRLNHTYSQLLKETEVL-QTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQY 1295 Query: 183 QRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKN 242 Q Q++ +L Q +L Q++G +E+ HL + Q+Q QN+ Sbjct: 1296 Q--------QLDITSTKLNNQCEL-LSQLKGNLEEENRHLLD-QIQTLMLQNR------- 1338 Query: 243 LHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPV 302 L +N + + +E+ + K+ + R Q +K E+KI Sbjct: 1339 ----------------TLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKF 1382 Query: 303 MHES-HHAQSEYIKSLKDKLVQEKKLSNMYQEQCISL 338 S + +I KL++ KK N +++ ++L Sbjct: 1383 YDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTL 1419 >gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] Length = 3907 Score = 63.5 bits (153), Expect = 4e-10 Identities = 100/482 (20%), Positives = 208/482 (43%), Gaps = 67/482 (13%) Query: 23 SKEL---LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDL---QQRE-----EE 71 S+EL LE + K+ E +++ L+ L+ E+ + Q L+ +L QQ++ ++ Sbjct: 3217 SRELQWALEKEKAKLGRSEERDKEELEDLKFSLES-QKQRNLQLNLLLEQQKQLLNESQQ 3275 Query: 72 IAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELE---DKKKIQNLLALVGTDAGEV 128 E Q+ L D Q+ Q R L++ E++++RIRE+ D+++ + G+ Sbjct: 3276 KIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQ- 3334 Query: 129 TYFCKEPPHKVTILQKTIQAVGECEQS-------ESSAFKADPKISKRRPSRERKESSEH 181 PP L K +Q E + S E+ +K D ++++ ++R+ + Sbjct: 3335 ----SRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKT 3390 Query: 182 YQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTK 241 Q + + E + Q+K+ E ++ +E++R + ++ ++ QR Q ++E K Sbjct: 3391 LQTEQEA---NTEGQKKMHELQSKV--EDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQK 3445 Query: 242 NLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLP 301 QEL E ++ ++ +N N+ +W L D + + Q +++ + KE K++ Sbjct: 3446 -----QELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIE 3500 Query: 302 VMHESHHAQSEYIKSLKDKL-VQEKKLSNMYQEQCISLEEELARIREEEGMRREI----- 355 M+ + ++ ++ KL KL + Q+ L+ E A + ++ I Sbjct: 3501 -MNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIIL 3559 Query: 356 -FKDRTNKMGKRLQIMTKRYE--ALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKA--- 409 + T + G+ +++ +L R + + I L ++ DL M+ K Sbjct: 3560 QLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQ 3619 Query: 410 -----------------TVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 452 ++N AN + + E NR +Q LK +++V+ L+ E Sbjct: 3620 IRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAE 3679 Query: 453 LR 454 LR Sbjct: 3680 LR 3681 Score = 57.0 bits (136), Expect = 3e-08 Identities = 102/520 (19%), Positives = 216/520 (41%), Gaps = 109/520 (20%) Query: 27 LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD-------LQQREEEIAELQKAL 79 +E QK+ + D+++++E + Q + E D +Q ++E I + + Sbjct: 401 VEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQM 460 Query: 80 SDMQVCLFQEREHVLRLYSE----NDRLRIR---------ELED----KKKIQNLLALVG 122 +M+ E E+ LR YS D++++ +L+D K+K++ L L+ Sbjct: 461 EEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLIL 520 Query: 123 TDAGEVTYFCKEPPHKVTI----LQKTIQAVGECEQSESSAFKA-----DPKISKRRPSR 173 + + ++ +++ +Q+ Q + E E + A K+ D K S Sbjct: 521 EEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASE 580 Query: 174 ERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHL----------- 222 RKE ++ ++ +++E L+ + E E +E R L Sbjct: 581 SRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKL 640 Query: 223 -EEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSK 281 E+++++H+ N K+K+ +H+ Q++ D LQ +E K ++ EKDNL++K Sbjct: 641 KEDLEIEHRINIEKLKD-NLGIHYKQQI------DGLQ--NEMSQKIETMQFEKDNLITK 691 Query: 282 IKQYRVQCKKKED------------------KIGKVLPVMHESHHAQSEYIKSLKDKLVQ 323 Q ++ K +D ++ K + ++ + + + +++ ++ Sbjct: 692 QNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLK 751 Query: 324 EKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRIL 383 + L +E+ L+E+ A++ E I KD + L+I T + R++ Sbjct: 752 TELLEKQMKEKENDLQEKFAQLEAE----NSILKDEKKTLEDMLKIHT---PVSQEERLI 804 Query: 384 EVEGFKT---------DIKVLRQKLKDLEQMLYK--------------ATVNARAN---- 416 ++ K+ +I++L ++ +DL+Q + A N N Sbjct: 805 FLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQEL 864 Query: 417 -QDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRL 455 ++ A L +V+D + K + EL+ KSK+ L EL L Sbjct: 865 QEEYACLLKVKD-DLEDSKNKQELE-YKSKLKALNEELHL 902 Score = 55.1 bits (131), Expect = 1e-07 Identities = 81/458 (17%), Positives = 193/458 (42%), Gaps = 38/458 (8%) Query: 14 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACE----GQHKLECDLQQRE 69 + + KL +++ +Q E E L L+ + C + +L+ D+Q+R Sbjct: 2084 QQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERN 2143 Query: 70 EEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVT 129 EEI +L+ + +++ L + ++ DR +E K ++ +L + + + Sbjct: 2144 EEIEKLEFRVRELEQALLVSADTFQKV---EDRKHFGAVEAKPEL-SLEVQLQAERDAID 2199 Query: 130 YFCKEPPHKVTILQKTIQAVG---ECEQSESSAFKADPKISKRRPS---RERKESSEHYQ 183 KE +T L++ ++ E + E +I K+ + +E ++ ++ ++ Sbjct: 2200 RKEKE----ITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFK 2255 Query: 184 RDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKN- 242 D++ L L ++ A + + + +I+++ + ++++ Q + Q ++K T N Sbjct: 2256 DDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNK 2315 Query: 243 -LHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLP 301 + EL+ + L S+ + K N +I+Q +K + ++ + Sbjct: 2316 VIEEKNELIRDLETQIECLMSDQE-------CVKRNREEEIEQLNEVIEKLQQELANIGQ 2368 Query: 302 VMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKD--- 358 + H+ SE SLK +L ++ + ++LE+++ EE + + K+ Sbjct: 2369 KTSMNAHSLSEEADSLKHQL-------DVVIAEKLALEQQVETANEEMTFMKNVLKETNF 2421 Query: 359 RTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQD 418 + N++ + L + + E++E+ + + I L + +LE +L + + + NQ Sbjct: 2422 KMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQT 2481 Query: 419 LALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456 E + ++ L L+S V + EL C Sbjct: 2482 YFKSFE-ENGKGSIINLETRLLQLESTVSAKDLELTQC 2518 Score = 52.8 bits (125), Expect = 7e-07 Identities = 100/510 (19%), Positives = 203/510 (39%), Gaps = 99/510 (19%) Query: 19 KLHPSKELLEYYQKKMAECEAENEDLLKKLELYK----EACEGQHKLECDLQQREEEIAE 74 +L LLE YQKK + + L +K+++Y+ + E +K E +Q++E I E Sbjct: 276 QLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEE--IQEKETIIEE 333 Query: 75 L---------------------QKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKK 113 L K L ++Q + Q+ + + + E + +E + ++ Sbjct: 334 LNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEE 393 Query: 114 IQNLLALVGT-----------DAGEVTYFCKEPPHKVTILQKTI-----QAVGECEQSES 157 I+ L+ V + V +E K+ L+ + Q + + +Q Sbjct: 394 IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELI 453 Query: 158 SAFKADPKISKRRPSRERKESSEHYQR--------------------DIQTLILQVEALQ 197 A + K R E + + Y +Q Q E L+ Sbjct: 454 RQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLK 513 Query: 198 AQLG---EQTKLSREQIEGLIEDRRIHLEEIQVQHQ---RNQNKIKELTKNLHHTQELLY 251 +LG E+ + Q+E L+E+ E+IQ Q ++K+ E K+L ++L Sbjct: 514 EELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKA 573 Query: 252 ESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQS 311 E + R E + K + +++ Y+++ + E + VL M ES A+ Sbjct: 574 EIV-SASESRKELELKHE----------AEVTNYKIKLEMLEKEKNAVLDRMAESQEAEL 622 Query: 312 EYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMR-REIFKDRTNKMGKRLQIM 370 E +++ + E++LS + ++ I + ++++ G+ ++ N+M ++++ M Sbjct: 623 ERLRT-QLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETM 681 Query: 371 TKRYEAL---ERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEV-- 425 + L + + ILE+ KLKDL+Q L + Q L E+ Sbjct: 682 QFEKDNLITKQNQLILEI-----------SKLKDLQQSLVNSKSEEMTLQINELQKEIEI 730 Query: 426 -RDSNRRAHKIQGELKNLKSKVFGLENELR 454 R + ++ E++ L+ K LE +++ Sbjct: 731 LRQEEKEKGTLEQEVQELQLKTELLEKQMK 760 Score = 51.6 bits (122), Expect = 1e-06 Identities = 88/410 (21%), Positives = 186/410 (45%), Gaps = 63/410 (15%) Query: 24 KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQ 83 + LL Q A+ L ++ E K + Q LE ++QQ++ ++ E+Q LS M Sbjct: 3088 RSLLSEIQALHAQMNGRKITLKREQESEKPS---QELLEYNIQQKQSQMLEMQVELSSM- 3143 Query: 84 VCLFQEREHVLRLYSENDRLRIREL-----EDKKKIQNLLALVGTDAGEVTYF---CKEP 135 ++R L+ ++++ + EL + K +++ L E+ F K+ Sbjct: 3144 ----KDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3199 Query: 136 PHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRER-KESSEHYQRDIQT---LIL 191 +V +L T+ E ++S + + + +K S ER KE E + +++ L Sbjct: 3200 TDEVHLLNDTL--ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNL 3257 Query: 192 QVEALQAQLGEQTKLSREQIEG--LIEDRRIHLE-----EIQVQHQRNQNKIKELTKNLH 244 Q+ L Q + S+++IE ++ D ++ E E+QV + + +I+E++ L Sbjct: 3258 QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLD 3317 Query: 245 HTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMH 304 +EL QL+S + + L ++L+ +++ K+ E+K +++ +++ Sbjct: 3318 REREL-------HAQLQSSDGTGQSRPPLPSEDLLKELQ------KQLEEKHSRIVELLN 3364 Query: 305 ESHHAQSEYIKSL----KDKLVQEKKLSNMYQ---------EQCISLEEELARIREEEGM 351 E+ + + +++ KD+ V K L + + S E+L R EE+ Sbjct: 3365 ETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEK-- 3422 Query: 352 RREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKD 401 R++++K + G+RLQ + + ++ E LE E + ++L Q L + Sbjct: 3423 RQQVYK--LDLEGQRLQGIMQEFQKQE----LEREEKRESRRILYQNLNE 3466 Score = 44.7 bits (104), Expect = 2e-04 Identities = 100/489 (20%), Positives = 196/489 (40%), Gaps = 86/489 (17%) Query: 22 PSKELLEYYQKKMAECEAENEDLLKKLELYK-EACEGQHKLECDLQ------QREEE--- 71 PS++LL+ QK++ E + +LL + E YK ++ + + ++E D Q Q E+E Sbjct: 3340 PSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANT 3399 Query: 72 -----IAELQKALSDMQVCLFQEREHVLRLYSENDRL-------RIRELEDKKKIQNLLA 119 + ELQ + D+Q L ++R+ V +L E RL + +ELE ++K ++ Sbjct: 3400 EGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRI 3459 Query: 120 LVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSE----------------------- 156 L T+ + +LQ+ I+ GE ++S Sbjct: 3460 LYQNLNEPTTWSLTSDRTRNWVLQQKIE--GETKESNYAKLIEMNGGGTGCNHELEMIRQ 3517 Query: 157 -----SSAFKADPKISKRRPSRERKESSEH--YQRDIQTLILQVEALQAQLGEQTKL-SR 208 +S + P+ + R E + + Q +I +ILQ++ L Q GE+ L S Sbjct: 3518 KLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSP 3577 Query: 209 EQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKE 268 G + +R + Q+ I +LT+ + + ++ + + R ++ Sbjct: 3578 STSCGSLTERLLR------QNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRD 3631 Query: 269 KSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLS 328 S + +L + +KE + L + A++E K LK +L + L Sbjct: 3632 NS---SRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYK-LKAELRNDSLL- 3686 Query: 329 NMYQEQCISLEEELARIREEEG--MRREIFKDRTNKMGKRLQIMTKRYEALERRRI---- 382 Q +S + E ++ G +R E F+ K L ++ ++ E + Sbjct: 3687 -----QTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLA 3741 Query: 383 -LEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELK- 440 + + TD++V+ + K + V+ ++ L+ RR H++ G + Sbjct: 3742 RMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLV-------RRWHRVTGSVSI 3794 Query: 441 NLKSKVFGL 449 N+ FGL Sbjct: 3795 NINRDGFGL 3803 Score = 40.8 bits (94), Expect = 0.003 Identities = 89/391 (22%), Positives = 157/391 (40%), Gaps = 65/391 (16%) Query: 5 LESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD 64 L+ P + E L PS+ + QK++ ++E DL ++E + + D Sbjct: 1072 LDHLPSVTKESSLRATQPSEN--DKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVD 1129 Query: 65 LQQREEEIAELQKALSDM-QVCLFQEREHVLRLYS----ENDRLRIRELEDKKKIQNLLA 119 Q RE E KAL + + +F + E + L E ++ +E D+ K +LL Sbjct: 1130 -QVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLI 1188 Query: 120 --LVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPS--RER 175 L + E +YF + ++L + +CE + + IS+ ++ Sbjct: 1189 GKLQKAVSEECSYFLQT---LCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDY 1245 Query: 176 KESSEHYQRDIQTLILQVE-------ALQAQL----GEQT----------KLSREQIEGL 214 + + +Q ++ TL+ +V LQ +L G+QT L +E+ E L Sbjct: 1246 RYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFL 1305 Query: 215 -IEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFL--QLRSENQNKEKSW 271 I + +LE+I V H+ + +++L K Q ES L QL+ QN E Sbjct: 1306 SIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEI 1365 Query: 272 MLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKS--------------- 316 + L + + + V D + V+ ES ++ Y S Sbjct: 1366 HCLQKRLQA-VSESTVPPSLPVDSV-----VITESDAQRTMYPGSCVKKNIDGTIEFSGE 1419 Query: 317 --LKDKLVQEKKLSNMYQEQCISLEEELARI 345 +K++ K L YQEQ LEEE+A++ Sbjct: 1420 FGVKEETNIVKLLEKQYQEQ---LEEEVAKV 1447 Score = 40.8 bits (94), Expect = 0.003 Identities = 67/315 (21%), Positives = 135/315 (42%), Gaps = 47/315 (14%) Query: 58 QHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNL 117 + +L D+ I+EL+ + +M L E+E V + +N LE +KK+ L Sbjct: 2594 EDELGSDISALTLRISELESQVVEMHTSLILEKEQV-EIAEKN------VLEKEKKLLEL 2646 Query: 118 LALV-GTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQS----ESSAFKADPKISKRRPS 172 L+ G + + K P V +L+ T + E+S E A +A+ ++ + Sbjct: 2647 QKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAE-SVATKAEL 2705 Query: 173 RERKESSEHYQRDIQTLILQVEALQ---AQLGEQTKLSREQIEGLIEDRRIHLEEIQVQH 229 KE +E Q ++ + +LQ +Q+ + ++E++ L ++ +E +VQ Sbjct: 2706 ASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKE-----DETEVQE 2760 Query: 230 QRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKD-----NLMSK--- 281 + + L L + + T L++ S NQ + +L K+ NL S+ Sbjct: 2761 SKKACMFEPLPIKL---SKSIASQTDGTLKISSSNQTPQ---ILVKNAGIQINLQSECSS 2814 Query: 282 ------IKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQC 335 I Q+ + +K ++ + M H +++E +K VQ + +E+C Sbjct: 2815 EEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQ------LLKEEC 2868 Query: 336 ISLEEELARIREEEG 350 +L+ + +R +EG Sbjct: 2869 GTLKAVIQCLRSKEG 2883 Score = 36.2 bits (82), Expect = 0.063 Identities = 61/334 (18%), Positives = 136/334 (40%), Gaps = 86/334 (25%) Query: 193 VEALQAQL-GEQTKLSREQIEGLIEDRRI--------HLEEIQVQHQRNQNKIKELTKNL 243 +E ++++L G+Q ++ E++ +E+ R+ L+E + ++ I +LT NL Sbjct: 157 LEMMESELAGKQHEI--EELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANL 214 Query: 244 HHTQELLYESTKDFLQLRSEN--------------------------------------- 264 + E+ ++FL+L ++ Sbjct: 215 QQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQ 274 Query: 265 -------------QNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGK--------VLPVM 303 Q K++ + ++ L KIK Y ++ KK + K ++ + Sbjct: 275 QQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEEL 334 Query: 304 HESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKM 363 + + + LKDKL KL QEQ + +E+ ++ + K + + Sbjct: 335 NTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMK----LELTNSKQKERQS 390 Query: 364 GKRLQIMTKRYEALERRRILEVEGFKTDI--KVLRQKLKDLEQMLYKATVNARANQDLAL 421 + ++ + E L++R + + F+TDI ++ ++ + LEQ+ +A ++ Q + Sbjct: 391 SEEIKQLMGTVEELQKRNHKDSQ-FETDIVQRMEQETQRKLEQL--RAELDEMYGQQIV- 446 Query: 422 LCEVRDSNRRAHKIQGELKNLKSKVFG-LENELR 454 +++ R H Q ++ +K++ G +EN LR Sbjct: 447 --QMKQELIRQHMAQ--MEEMKTRHKGEMENALR 476 Score = 30.0 bits (66), Expect = 4.5 Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 15/76 (19%) Query: 42 EDLLKKLEL--YKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSE 99 E + K EL YKE E KL+ +L +E + LQK LS Q R+H L Sbjct: 2697 ESVATKAELASYKEKAE---KLQEELLVKETNMTSLQKDLS-------QVRDH---LAEA 2743 Query: 100 NDRLRIRELEDKKKIQ 115 ++L I E ED+ ++Q Sbjct: 2744 KEKLSILEKEDETEVQ 2759 >gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] Length = 3899 Score = 63.5 bits (153), Expect = 4e-10 Identities = 100/482 (20%), Positives = 208/482 (43%), Gaps = 67/482 (13%) Query: 23 SKEL---LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDL---QQRE-----EE 71 S+EL LE + K+ E +++ L+ L+ E+ + Q L+ +L QQ++ ++ Sbjct: 3209 SRELQWALEKEKAKLGRSEERDKEELEDLKFSLES-QKQRNLQLNLLLEQQKQLLNESQQ 3267 Query: 72 IAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELE---DKKKIQNLLALVGTDAGEV 128 E Q+ L D Q+ Q R L++ E++++RIRE+ D+++ + G+ Sbjct: 3268 KIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQ- 3326 Query: 129 TYFCKEPPHKVTILQKTIQAVGECEQS-------ESSAFKADPKISKRRPSRERKESSEH 181 PP L K +Q E + S E+ +K D ++++ ++R+ + Sbjct: 3327 ----SRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKT 3382 Query: 182 YQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTK 241 Q + + E + Q+K+ E ++ +E++R + ++ ++ QR Q ++E K Sbjct: 3383 LQTEQEA---NTEGQKKMHELQSKV--EDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQK 3437 Query: 242 NLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLP 301 QEL E ++ ++ +N N+ +W L D + + Q +++ + KE K++ Sbjct: 3438 -----QELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIE 3492 Query: 302 VMHESHHAQSEYIKSLKDKL-VQEKKLSNMYQEQCISLEEELARIREEEGMRREI----- 355 M+ + ++ ++ KL KL + Q+ L+ E A + ++ I Sbjct: 3493 -MNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIIL 3551 Query: 356 -FKDRTNKMGKRLQIMTKRYE--ALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKA--- 409 + T + G+ +++ +L R + + I L ++ DL M+ K Sbjct: 3552 QLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQ 3611 Query: 410 -----------------TVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 452 ++N AN + + E NR +Q LK +++V+ L+ E Sbjct: 3612 IRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAE 3671 Query: 453 LR 454 LR Sbjct: 3672 LR 3673 Score = 57.4 bits (137), Expect = 3e-08 Identities = 86/465 (18%), Positives = 197/465 (42%), Gaps = 60/465 (12%) Query: 14 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACE----GQHKLECDLQQRE 69 + + KL +++ +Q E E L L+ + C + +L+ D+Q+R Sbjct: 2084 QQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERN 2143 Query: 70 EEIAELQKALSDM-QVCLFQEREHV------------LRLYSENDRLRIRELEDKKKIQN 116 EEI +L+ + ++ Q L ++R+H ++L +E D + +E K+I N Sbjct: 2144 EEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKE----KEITN 2199 Query: 117 LLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERK 176 L ++ F +E +K +Q+ + E ++ ES+ +E + Sbjct: 2200 L-------EEQLEQFREELENKNEEVQQLHMQL-EIQKKESTT-----------RLQELE 2240 Query: 177 ESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKI 236 + ++ ++ D++ L L ++ A + + + +I+++ + ++++ Q + Q ++ Sbjct: 2241 QENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL 2300 Query: 237 KELTKN--LHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKED 294 K T N + EL+ + L S+ + K N +I+Q +K + Sbjct: 2301 KITTDNKVIEEKNELIRDLETQIECLMSDQE-------CVKRNREEEIEQLNEVIEKLQQ 2353 Query: 295 KIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRRE 354 ++ + + H+ SE SLK +L ++ + ++LE+++ EE + Sbjct: 2354 ELANIGQKTSMNAHSLSEEADSLKHQL-------DVVIAEKLALEQQVETANEEMTFMKN 2406 Query: 355 IFKD---RTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATV 411 + K+ + N++ + L + + E++E+ + + I L + +LE +L + + Sbjct: 2407 VLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDAL 2466 Query: 412 NARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456 + NQ E + ++ L L+S V + EL C Sbjct: 2467 KSLENQTYFKSFE-ENGKGSIINLETRLLQLESTVSAKDLELTQC 2510 Score = 57.0 bits (136), Expect = 3e-08 Identities = 102/520 (19%), Positives = 216/520 (41%), Gaps = 109/520 (20%) Query: 27 LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD-------LQQREEEIAELQKAL 79 +E QK+ + D+++++E + Q + E D +Q ++E I + + Sbjct: 401 VEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQM 460 Query: 80 SDMQVCLFQEREHVLRLYSE----NDRLRIR---------ELED----KKKIQNLLALVG 122 +M+ E E+ LR YS D++++ +L+D K+K++ L L+ Sbjct: 461 EEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLIL 520 Query: 123 TDAGEVTYFCKEPPHKVTI----LQKTIQAVGECEQSESSAFKA-----DPKISKRRPSR 173 + + ++ +++ +Q+ Q + E E + A K+ D K S Sbjct: 521 EEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASE 580 Query: 174 ERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHL----------- 222 RKE ++ ++ +++E L+ + E E +E R L Sbjct: 581 SRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKL 640 Query: 223 -EEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSK 281 E+++++H+ N K+K+ +H+ Q++ D LQ +E K ++ EKDNL++K Sbjct: 641 KEDLEIEHRINIEKLKD-NLGIHYKQQI------DGLQ--NEMSQKIETMQFEKDNLITK 691 Query: 282 IKQYRVQCKKKED------------------KIGKVLPVMHESHHAQSEYIKSLKDKLVQ 323 Q ++ K +D ++ K + ++ + + + +++ ++ Sbjct: 692 QNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLK 751 Query: 324 EKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRIL 383 + L +E+ L+E+ A++ E I KD + L+I T + R++ Sbjct: 752 TELLEKQMKEKENDLQEKFAQLEAE----NSILKDEKKTLEDMLKIHT---PVSQEERLI 804 Query: 384 EVEGFKT---------DIKVLRQKLKDLEQMLYK--------------ATVNARAN---- 416 ++ K+ +I++L ++ +DL+Q + A N N Sbjct: 805 FLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQEL 864 Query: 417 -QDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRL 455 ++ A L +V+D + K + EL+ KSK+ L EL L Sbjct: 865 QEEYACLLKVKD-DLEDSKNKQELE-YKSKLKALNEELHL 902 Score = 52.8 bits (125), Expect = 7e-07 Identities = 100/510 (19%), Positives = 203/510 (39%), Gaps = 99/510 (19%) Query: 19 KLHPSKELLEYYQKKMAECEAENEDLLKKLELYK----EACEGQHKLECDLQQREEEIAE 74 +L LLE YQKK + + L +K+++Y+ + E +K E +Q++E I E Sbjct: 276 QLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEE--IQEKETIIEE 333 Query: 75 L---------------------QKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKK 113 L K L ++Q + Q+ + + + E + +E + ++ Sbjct: 334 LNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEE 393 Query: 114 IQNLLALVGT-----------DAGEVTYFCKEPPHKVTILQKTI-----QAVGECEQSES 157 I+ L+ V + V +E K+ L+ + Q + + +Q Sbjct: 394 IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELI 453 Query: 158 SAFKADPKISKRRPSRERKESSEHYQR--------------------DIQTLILQVEALQ 197 A + K R E + + Y +Q Q E L+ Sbjct: 454 RQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLK 513 Query: 198 AQLG---EQTKLSREQIEGLIEDRRIHLEEIQVQHQ---RNQNKIKELTKNLHHTQELLY 251 +LG E+ + Q+E L+E+ E+IQ Q ++K+ E K+L ++L Sbjct: 514 EELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKA 573 Query: 252 ESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQS 311 E + R E + K + +++ Y+++ + E + VL M ES A+ Sbjct: 574 EIV-SASESRKELELKHE----------AEVTNYKIKLEMLEKEKNAVLDRMAESQEAEL 622 Query: 312 EYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMR-REIFKDRTNKMGKRLQIM 370 E +++ + E++LS + ++ I + ++++ G+ ++ N+M ++++ M Sbjct: 623 ERLRT-QLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETM 681 Query: 371 TKRYEAL---ERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEV-- 425 + L + + ILE+ KLKDL+Q L + Q L E+ Sbjct: 682 QFEKDNLITKQNQLILEI-----------SKLKDLQQSLVNSKSEEMTLQINELQKEIEI 730 Query: 426 -RDSNRRAHKIQGELKNLKSKVFGLENELR 454 R + ++ E++ L+ K LE +++ Sbjct: 731 LRQEEKEKGTLEQEVQELQLKTELLEKQMK 760 Score = 51.6 bits (122), Expect = 1e-06 Identities = 88/410 (21%), Positives = 186/410 (45%), Gaps = 63/410 (15%) Query: 24 KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQ 83 + LL Q A+ L ++ E K + Q LE ++QQ++ ++ E+Q LS M Sbjct: 3080 RSLLSEIQALHAQMNGRKITLKREQESEKPS---QELLEYNIQQKQSQMLEMQVELSSM- 3135 Query: 84 VCLFQEREHVLRLYSENDRLRIREL-----EDKKKIQNLLALVGTDAGEVTYF---CKEP 135 ++R L+ ++++ + EL + K +++ L E+ F K+ Sbjct: 3136 ----KDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3191 Query: 136 PHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRER-KESSEHYQRDIQT---LIL 191 +V +L T+ E ++S + + + +K S ER KE E + +++ L Sbjct: 3192 TDEVHLLNDTL--ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNL 3249 Query: 192 QVEALQAQLGEQTKLSREQIEG--LIEDRRIHLE-----EIQVQHQRNQNKIKELTKNLH 244 Q+ L Q + S+++IE ++ D ++ E E+QV + + +I+E++ L Sbjct: 3250 QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLD 3309 Query: 245 HTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMH 304 +EL QL+S + + L ++L+ +++ K+ E+K +++ +++ Sbjct: 3310 REREL-------HAQLQSSDGTGQSRPPLPSEDLLKELQ------KQLEEKHSRIVELLN 3356 Query: 305 ESHHAQSEYIKSL----KDKLVQEKKLSNMYQ---------EQCISLEEELARIREEEGM 351 E+ + + +++ KD+ V K L + + S E+L R EE+ Sbjct: 3357 ETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEK-- 3414 Query: 352 RREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKD 401 R++++K + G+RLQ + + ++ E LE E + ++L Q L + Sbjct: 3415 RQQVYK--LDLEGQRLQGIMQEFQKQE----LEREEKRESRRILYQNLNE 3458 Score = 44.7 bits (104), Expect = 2e-04 Identities = 100/489 (20%), Positives = 196/489 (40%), Gaps = 86/489 (17%) Query: 22 PSKELLEYYQKKMAECEAENEDLLKKLELYK-EACEGQHKLECDLQ------QREEE--- 71 PS++LL+ QK++ E + +LL + E YK ++ + + ++E D Q Q E+E Sbjct: 3332 PSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANT 3391 Query: 72 -----IAELQKALSDMQVCLFQEREHVLRLYSENDRL-------RIRELEDKKKIQNLLA 119 + ELQ + D+Q L ++R+ V +L E RL + +ELE ++K ++ Sbjct: 3392 EGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRI 3451 Query: 120 LVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSE----------------------- 156 L T+ + +LQ+ I+ GE ++S Sbjct: 3452 LYQNLNEPTTWSLTSDRTRNWVLQQKIE--GETKESNYAKLIEMNGGGTGCNHELEMIRQ 3509 Query: 157 -----SSAFKADPKISKRRPSRERKESSEH--YQRDIQTLILQVEALQAQLGEQTKL-SR 208 +S + P+ + R E + + Q +I +ILQ++ L Q GE+ L S Sbjct: 3510 KLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSP 3569 Query: 209 EQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKE 268 G + +R + Q+ I +LT+ + + ++ + + R ++ Sbjct: 3570 STSCGSLTERLLR------QNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRD 3623 Query: 269 KSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLS 328 S + +L + +KE + L + A++E K LK +L + L Sbjct: 3624 NS---SRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYK-LKAELRNDSLL- 3678 Query: 329 NMYQEQCISLEEELARIREEEG--MRREIFKDRTNKMGKRLQIMTKRYEALERRRI---- 382 Q +S + E ++ G +R E F+ K L ++ ++ E + Sbjct: 3679 -----QTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLA 3733 Query: 383 -LEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELK- 440 + + TD++V+ + K + V+ ++ L+ RR H++ G + Sbjct: 3734 RMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLV-------RRWHRVTGSVSI 3786 Query: 441 NLKSKVFGL 449 N+ FGL Sbjct: 3787 NINRDGFGL 3795 Score = 40.8 bits (94), Expect = 0.003 Identities = 89/391 (22%), Positives = 157/391 (40%), Gaps = 65/391 (16%) Query: 5 LESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD 64 L+ P + E L PS+ + QK++ ++E DL ++E + + D Sbjct: 1072 LDHLPSVTKESSLRATQPSEN--DKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVD 1129 Query: 65 LQQREEEIAELQKALSDM-QVCLFQEREHVLRLYS----ENDRLRIRELEDKKKIQNLLA 119 Q RE E KAL + + +F + E + L E ++ +E D+ K +LL Sbjct: 1130 -QVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLI 1188 Query: 120 --LVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPS--RER 175 L + E +YF + ++L + +CE + + IS+ ++ Sbjct: 1189 GKLQKAVSEECSYFLQT---LCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDY 1245 Query: 176 KESSEHYQRDIQTLILQVE-------ALQAQL----GEQT----------KLSREQIEGL 214 + + +Q ++ TL+ +V LQ +L G+QT L +E+ E L Sbjct: 1246 RYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFL 1305 Query: 215 -IEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFL--QLRSENQNKEKSW 271 I + +LE+I V H+ + +++L K Q ES L QL+ QN E Sbjct: 1306 SIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEI 1365 Query: 272 MLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKS--------------- 316 + L + + + V D + V+ ES ++ Y S Sbjct: 1366 HCLQKRLQA-VSESTVPPSLPVDSV-----VITESDAQRTMYPGSCVKKNIDGTIEFSGE 1419 Query: 317 --LKDKLVQEKKLSNMYQEQCISLEEELARI 345 +K++ K L YQEQ LEEE+A++ Sbjct: 1420 FGVKEETNIVKLLEKQYQEQ---LEEEVAKV 1447 Score = 40.8 bits (94), Expect = 0.003 Identities = 67/315 (21%), Positives = 135/315 (42%), Gaps = 47/315 (14%) Query: 58 QHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNL 117 + +L D+ I+EL+ + +M L E+E V + +N LE +KK+ L Sbjct: 2586 EDELGSDISALTLRISELESQVVEMHTSLILEKEQV-EIAEKN------VLEKEKKLLEL 2638 Query: 118 LALV-GTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQS----ESSAFKADPKISKRRPS 172 L+ G + + K P V +L+ T + E+S E A +A+ ++ + Sbjct: 2639 QKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAE-SVATKAEL 2697 Query: 173 RERKESSEHYQRDIQTLILQVEALQ---AQLGEQTKLSREQIEGLIEDRRIHLEEIQVQH 229 KE +E Q ++ + +LQ +Q+ + ++E++ L ++ +E +VQ Sbjct: 2698 ASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKE-----DETEVQE 2752 Query: 230 QRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKD-----NLMSK--- 281 + + L L + + T L++ S NQ + +L K+ NL S+ Sbjct: 2753 SKKACMFEPLPIKL---SKSIASQTDGTLKISSSNQTPQ---ILVKNAGIQINLQSECSS 2806 Query: 282 ------IKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQC 335 I Q+ + +K ++ + M H +++E +K VQ + +E+C Sbjct: 2807 EEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQ------LLKEEC 2860 Query: 336 ISLEEELARIREEEG 350 +L+ + +R +EG Sbjct: 2861 GTLKAVIQCLRSKEG 2875 Score = 36.2 bits (82), Expect = 0.063 Identities = 61/334 (18%), Positives = 136/334 (40%), Gaps = 86/334 (25%) Query: 193 VEALQAQL-GEQTKLSREQIEGLIEDRRI--------HLEEIQVQHQRNQNKIKELTKNL 243 +E ++++L G+Q ++ E++ +E+ R+ L+E + ++ I +LT NL Sbjct: 157 LEMMESELAGKQHEI--EELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANL 214 Query: 244 HHTQELLYESTKDFLQLRSEN--------------------------------------- 264 + E+ ++FL+L ++ Sbjct: 215 QQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQ 274 Query: 265 -------------QNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGK--------VLPVM 303 Q K++ + ++ L KIK Y ++ KK + K ++ + Sbjct: 275 QQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEEL 334 Query: 304 HESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKM 363 + + + LKDKL KL QEQ + +E+ ++ + K + + Sbjct: 335 NTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMK----LELTNSKQKERQS 390 Query: 364 GKRLQIMTKRYEALERRRILEVEGFKTDI--KVLRQKLKDLEQMLYKATVNARANQDLAL 421 + ++ + E L++R + + F+TDI ++ ++ + LEQ+ +A ++ Q + Sbjct: 391 SEEIKQLMGTVEELQKRNHKDSQ-FETDIVQRMEQETQRKLEQL--RAELDEMYGQQIV- 446 Query: 422 LCEVRDSNRRAHKIQGELKNLKSKVFG-LENELR 454 +++ R H Q ++ +K++ G +EN LR Sbjct: 447 --QMKQELIRQHMAQ--MEEMKTRHKGEMENALR 476 Score = 30.0 bits (66), Expect = 4.5 Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 15/76 (19%) Query: 42 EDLLKKLEL--YKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSE 99 E + K EL YKE E KL+ +L +E + LQK LS Q R+H L Sbjct: 2689 ESVATKAELASYKEKAE---KLQEELLVKETNMTSLQKDLS-------QVRDH---LAEA 2735 Query: 100 NDRLRIRELEDKKKIQ 115 ++L I E ED+ ++Q Sbjct: 2736 KEKLSILEKEDETEVQ 2751 >gi|71061468 centromere protein E [Homo sapiens] Length = 2701 Score = 63.5 bits (153), Expect = 4e-10 Identities = 93/456 (20%), Positives = 205/456 (44%), Gaps = 61/456 (13%) Query: 20 LHPSKELLEYYQKKMAECEAENEDLLKKLEL-YKEACEGQHKLECDLQQREEEIAELQKA 78 L + L+ K++ E E+ LK KE E ++L +L ++E EI+ +QK Sbjct: 1454 LQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQ 1513 Query: 79 LSDMQVCLFQEREHVLRLYSENDRLRIREL--------------EDKKKIQNLLALVGTD 124 L + L + + +Y + ++ I+++ E +K + L + + Sbjct: 1514 LEAINDKL---QNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESK 1570 Query: 125 AGEVTYFCKEPPHKVTIL---QKTIQAVGECEQSESSAFKADPK--ISKRRPSRERKESS 179 E+T +E ++ I+ ++ ++ V E Q E K + K ++K + S+E++ Sbjct: 1571 MLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKE--- 1627 Query: 180 EHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKEL 239 YQ T + + + ++ E ++ E ++++LE I+ ++ R L Sbjct: 1628 --YQFLKMTAVNETQEKMCEI--------EHLKEQFETQKLNLENIETENIR-------L 1670 Query: 240 TKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKV 299 T+ LH E + TK+ R + ++ E++ +E+D L +++ + +K+++ Sbjct: 1671 TQILHENLEEMRSVTKE----RDDLRSVEETLKVERDQLKENLRETITRDLEKQEE---- 1722 Query: 300 LPVMHESHHAQSEYIKSLKDKLVQEK--KLSNMYQE---QCISLEEELARIREEEGMRRE 354 L ++H E I L+ +V EK ++SNM ++ +L+ + +I+EE + Sbjct: 1723 LKIVHMHLKEHQETIDKLRG-IVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHM 1781 Query: 355 IFKDRTNKMGKRLQIMTKRYEALER-RRILEVEGFKTDIKVLRQKLKDLEQMLYKATVN- 412 K++ + K I++++ + L ++ LE K K+ K + + + K VN Sbjct: 1782 HLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNE 1841 Query: 413 --ARANQDLALLCEVRDSNRRAHKIQGELKNLKSKV 446 + ++ L +++D + K++ E NL K+ Sbjct: 1842 TQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKL 1877 Score = 60.8 bits (146), Expect = 2e-09 Identities = 102/495 (20%), Positives = 210/495 (42%), Gaps = 76/495 (15%) Query: 5 LESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD 64 L+ T + ++++ ++ KE E + + E EN L + L E K D Sbjct: 1631 LKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDD 1690 Query: 65 LQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIREL---EDKKKIQNLLALV 121 L+ EE + + L + RE + R + + L+I + E ++ I L +V Sbjct: 1691 LRSVEETLKVERDQLKE------NLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIV 1744 Query: 122 GTDAGEVTYFCKEPPHKVTILQ-KTIQAVGECEQSESSAFKADPKISKRRP-SRERKESS 179 E++ K+ H L+ + ++ E + + I K R E+ + Sbjct: 1745 SEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKL 1804 Query: 180 EHYQRD-------IQTLILQVEALQAQL--------GEQTKLSR-EQIEGLIEDRRIHLE 223 + Q+D +Q I +++A + QL Q K+S EQ++ I+D+ + L Sbjct: 1805 SNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLS 1864 Query: 224 EIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNL----- 278 +++++ N N ++L +NL E K ++ R + E++ LE+D L Sbjct: 1865 KLEIE---NLNLAQKLHENL--------EEMKSVMKERDNLRRVEETLKLERDQLKESLQ 1913 Query: 279 ---------MSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSL-KDKLVQEKKLS 328 ++K R+ K+ ++ + K+ + E S+ K L K K +KK+ Sbjct: 1914 ETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQ 1973 Query: 329 NMYQE--QCISLEEEL----ARIREEEGMRREIFKDRTNKMGKRL---QIMTKRYEALER 379 + ++ Q + ++E++ +I E E ++++ + R+ Q+ K +E+LE Sbjct: 1974 ELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEE 2033 Query: 380 RRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGEL 439 RI+ E + +++ +++ LK +Q +A L E+ +R+ H+++ E Sbjct: 2034 IRIVAKE--RDELRRIKESLK------------MERDQFIATLREMIARDRQNHQVKPEK 2079 Query: 440 KNLKSKVFGLENELR 454 + L L LR Sbjct: 2080 RLLSDGQQHLTESLR 2094 Score = 58.9 bits (141), Expect = 9e-09 Identities = 98/506 (19%), Positives = 205/506 (40%), Gaps = 80/506 (15%) Query: 25 ELLEYYQKKMAECEAENE--DLLKKLELYKEACEGQHKLECDLQ-QREEEIAELQKALSD 81 E++E +K + + +NE +L+ + KE + K ++ + +EE+ L L Sbjct: 1037 EIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKK 1096 Query: 82 MQVCLFQEREHVLRLYSENDRL--RIRELEDKKK---------------IQNLLALVGTD 124 Q + QE+ H ++ E R R+ E+E+K K +Q ++ + Sbjct: 1097 QQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKK 1156 Query: 125 AGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQR 184 E+ E +K L+ E Q + ++ I+K R + + S +R Sbjct: 1157 INEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETER 1216 Query: 185 D-IQTLILQVEALQAQLGEQTKLS----REQIEGLIEDRR---------IHLEEIQVQHQ 230 D ++ I ++EA Q E+ K++ +E E + E RR I+ ++++ H Sbjct: 1217 DHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHT 1276 Query: 231 RNQNKIKEL---------TKNLHHTQELLYE--------STKDFLQLR------------ 261 + Q +I L K + TQE + E +TKD L Sbjct: 1277 KLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEK 1336 Query: 262 -SENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLK-- 318 E+Q + KS E+DNL + + V+ + ++ I + L + ES Q + + + Sbjct: 1337 FQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKD 1396 Query: 319 ---DKLVQEKKLSNMYQEQCISLEEEL----ARIREEEGMRREIFKDRTNKMGKRLQIMT 371 K+V E + + +E E+ R++E + + K++ + + + + Sbjct: 1397 NETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQS 1456 Query: 372 KRYEALERRRILEVEGFKT--DIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSN 429 + + E + + + +T ++KV LK+ E+ + + VN + E+ Sbjct: 1457 ESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKE-----TEISTIQ 1511 Query: 430 RRAHKIQGELKNLKSKVFGLENELRL 455 ++ I +L+N +++ E + + Sbjct: 1512 KQLEAINDKLQNKIQEIYEKEEQFNI 1537 Score = 48.5 bits (114), Expect = 1e-05 Identities = 97/502 (19%), Positives = 199/502 (39%), Gaps = 101/502 (20%) Query: 31 QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEI------------------ 72 ++KM E + + ++LY+ E + K++ DL++ + Sbjct: 652 KEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKD 711 Query: 73 ----AELQKALSDMQVCLFQE-------REHVL------RLYSENDRLRIRELEDKKKIQ 115 EL+ ++D+Q L +E RE V+ L SE +RLR +E++DK + Sbjct: 712 LLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLR-KEIQDKSEEL 770 Query: 116 NLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQ----SESSAFKADPKISKRRP 171 +++ E E HK + +Q ++ +G+ + ++S+ D + + Sbjct: 771 HII------TSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKT 824 Query: 172 SR---ERK-----ESSEHYQRDIQTLILQVEALQAQLGE-QTKLSREQIE-----GLIED 217 E+K E +E ++I L + + + LG +T+LS + E +++ Sbjct: 825 LHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQE 884 Query: 218 RRIHLEEIQVQHQRNQNKIKELTKNLHHTQELL---YESTKDFLQLRSENQNKEKSWMLE 274 R +E+++ Q + + ++ + + E L E K Q + + + ++S +E Sbjct: 885 RLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIE 944 Query: 275 KDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQ 334 +D L S I ++++ L ES E I +LK K+ +E + Sbjct: 945 RDQLKSDIHDTVNMNIDTQEQLRNAL----ESLKQHQETINTLKSKISEEVSRN------ 994 Query: 335 CISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMT---KRYEALERRR---------- 381 + +EE ++E + + + K Q +T K E +E++R Sbjct: 995 -LHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKN 1053 Query: 382 ---------ILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRA 432 I E E KTD+K + + ++ L + Q++ V A Sbjct: 1054 ELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEI-----VAQEKNHA 1108 Query: 433 HKIQGELKNLKSKVFGLENELR 454 K +GEL ++ +E +L+ Sbjct: 1109 IKKEGELSRTCDRLAEVEEKLK 1130 Score = 45.1 bits (105), Expect = 1e-04 Identities = 76/411 (18%), Positives = 180/411 (43%), Gaps = 36/411 (8%) Query: 19 KLHPSKELLEYYQKKMAECEAEN----EDLLKKLELYKEACEGQHKLECDLQQREEEIAE 74 ++ P K LL Q+ + E E ++LLK+ + E ++L DL++ E E Sbjct: 2074 QVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKE 2133 Query: 75 LQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKE 134 L + + + +H+ +L++ N R + KK++ +L+ V KE Sbjct: 2134 LSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTK--------IKE 2185 Query: 135 PPHKVTILQKTIQAVGECEQSESSAFKADP-KISKRRPSRERKESSEHYQRDIQTLILQV 193 H+ +I + + + E E+ + K + PSRE ++ + D+ + Sbjct: 2186 EQHE-SINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILK 2244 Query: 194 EALQAQLG------EQTKLSREQIEGLIED---RRIHLEEIQVQHQRNQNKIKELTKNLH 244 + +++ +Q +R+++ +E+ R +E+++ Q+ ++I ++ + Sbjct: 2245 DFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFN 2304 Query: 245 HTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMH 304 + + + +F + RS +KE W + +L K ++ + + + V Sbjct: 2305 NRIIAIMNESTEF-EERSATISKE--WEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNP 2361 Query: 305 ESHHAQSEYIKSLKDKLVQEK--KLSNMY---QEQCISLEEELARIREEEGMRREI---F 356 + ++ ++ S +L EK +L N +E + E ++ ++++E + +I Sbjct: 2362 TTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKL 2421 Query: 357 KDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLK--DLEQM 405 + + ++ K L+ + + L+ + L + +K +I+ L+ KL DLE+M Sbjct: 2422 QAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKM 2472 Score = 44.7 bits (104), Expect = 2e-04 Identities = 69/386 (17%), Positives = 165/386 (42%), Gaps = 43/386 (11%) Query: 24 KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAE-LQKALSDM 82 K L Y +++ E E ++ L ++E KE E + +++ + I E LQ+ L ++ Sbjct: 865 KTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEV 924 Query: 83 QVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTIL 142 + L QE++ + +L + L+I + K I + + + + Sbjct: 925 KT-LTQEKDDLKQL---QESLQIERDQLKSDIHDTVNM-----------------NIDTQ 963 Query: 143 QKTIQAVGECEQSESSAFKADPKISKR-RPSRERKESSEHYQRDIQTLILQVEALQAQLG 201 ++ A+ +Q + + KIS+ + +E++ + + Q ++ ++ Q Sbjct: 964 EQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEA 1023 Query: 202 EQTKLSREQIEG--LIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQ 259 + T+ ++ +IE +R IQ +N+++++ +++ +E L K+ ++ Sbjct: 1024 KNTQTLTADVKDNEIIEQQRKIFSLIQ-----EKNELQQMLESVIAEKEQLKTDLKENIE 1078 Query: 260 LRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKD 319 + ENQ + + E + Q + KKE ++ + + E E + L++ Sbjct: 1079 MTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQE 1138 Query: 320 KLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALER 379 K Q+Q ++++EE++ ++++ + + NK + T+R E ++ Sbjct: 1139 K-----------QQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQK 1187 Query: 380 --RRILEVEGFKTDIKVLRQKLKDLE 403 EV+ + KVL++ K E Sbjct: 1188 LNENYEEVKSITKERKVLKELQKSFE 1213 Score = 39.7 bits (91), Expect = 0.006 Identities = 84/439 (19%), Positives = 185/439 (42%), Gaps = 52/439 (11%) Query: 14 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEI- 72 ++RL ++ KE LE + E E + +KL+ E + + + DL+Q +E + Sbjct: 883 QERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQ 942 Query: 73 AELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFC 132 E + SD+ + + +L + + L+ + ++ I L + + + + Sbjct: 943 IERDQLKSDIHDTVNMNIDTQEQLRNALESLK----QHQETINTLKSKISEEVSRNLHME 998 Query: 133 KEPPHKVTILQKTIQAVG---ECEQSESSAFKADPK----ISKRRPSRERKESSEHYQRD 185 + Q+ + + + E + AD K I ++R + Q+ Sbjct: 999 ENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQM 1058 Query: 186 IQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHH 245 ++++I + E L+ L +E IE IE NQ +++ L L Sbjct: 1059 LESVIAEKEQLKTDL-------KENIEMTIE---------------NQEELRLLGDELKK 1096 Query: 246 TQELLYESTKDFLQLRSE-NQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMH 304 QE++ + ++ E ++ ++ +E+ K+K+ Q ++K+ ++ V M Sbjct: 1097 QQEIVAQEKNHAIKKEGELSRTCDRLAEVEE-----KLKEKSQQLQEKQQQLLNVQEEMS 1151 Query: 305 ESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMG 364 E +E I++LK++L ++ + + + L ++L EE + I K+R K+ Sbjct: 1152 EMQKKINE-IENLKNELKNKELTLEHMETERLELAQKLNENYEEV---KSITKER--KVL 1205 Query: 365 KRLQ--IMTKRYEALERRRILEVEGFKT--DIKVLRQKLKDLEQMLYKATVNARANQDLA 420 K LQ T+R R +E G +T ++K+ LK+ ++ + + + ++ A Sbjct: 1206 KELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDE--LRRSVSEKTA 1263 Query: 421 LLCEVRDSNRRAHKIQGEL 439 + +D + K+Q E+ Sbjct: 1264 QIINTQDLEKSHTKLQEEI 1282 >gi|8922940 gamma-taxilin [Homo sapiens] Length = 528 Score = 63.5 bits (153), Expect = 4e-10 Identities = 91/409 (22%), Positives = 175/409 (42%), Gaps = 57/409 (13%) Query: 35 AECEAENEDLLKKLELYKEACEGQHKLECDLQQRE---EEIAELQKALSDMQVCLFQERE 91 A C E+ + + E + +GQ EC+ + + +E+ L +AL+ + E Sbjct: 99 AYCTQESREEIPGGEARTDPPDGQQDSECNRNKEKTLGKEVLLLMQALNTLST----PEE 154 Query: 92 HVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGE 151 + L + L LE+ + +Q + ++ ++ KE H + K I A + Sbjct: 155 KLAALCKKYADL----LEESRSVQKQMKILQKKQAQIV---KEKVHLQSEHSKAILARSK 207 Query: 152 CE------QSESSAFKADPKISKRRPSRERKESSEHYQ---RDIQTLILQVEALQAQLGE 202 E Q + K + R RKE++ H+Q +IQ + Q + A+L + Sbjct: 208 LESLCRELQRHNKTLKEENMQQAREEEERRKEATAHFQITLDEIQAQLEQHDIHNAKLRQ 267 Query: 203 QTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRS 262 + E+++ LIE + E I +R + + + + L T +L+ E+ Sbjct: 268 ENIELGEKLKKLIEQYALREEHIDKVFKRKELQQQLVDAKLQQTTQLIKEA--------D 319 Query: 263 ENQNKEKSWML----EKDNLMSKIKQYRVQCKKK----EDKIGKVLPVMHESHHAQSEYI 314 E +E+ ++L E + ++KQ VQ K++ DK + M +S+ + + Sbjct: 320 EKHQREREFLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFR 379 Query: 315 KSLKDKLVQEKKLSN---MYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMT 371 + ++ + KKL +++ + + + L ++ EE+ +R +K K LQI Sbjct: 380 QEMEKMTKKIKKLEKETIIWRTKWENNNKALLQMAEEKTVR--------DKEYKALQIKL 431 Query: 372 KRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420 +R E L R E ++VL+ EQ+ KA + A AN+DLA Sbjct: 432 ERLEKLCRALQTERNELNEKVEVLK------EQVSIKAAIKA-ANRDLA 473 Score = 35.8 bits (81), Expect = 0.083 Identities = 58/240 (24%), Positives = 105/240 (43%), Gaps = 29/240 (12%) Query: 204 TKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSE 263 T+ SRE+I G + R + Q + N+NK K L K + + L +T + + Sbjct: 102 TQESREEIPG--GEARTDPPDGQQDSECNRNKEKTLGKEVLLLMQAL--NTLSTPEEKLA 157 Query: 264 NQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQ 323 K+ + +LE+ + K Q ++ KK+ ++ E H QSE+ K++ + Sbjct: 158 ALCKKYADLLEESRSVQK--QMKILQKKQAQ-------IVKEKVHLQSEHSKAILARSKL 208 Query: 324 EKKLSNMYQEQCISLEEELARIREEEGMRREI---FKDRTNKMGKRLQIMTKRYEALERR 380 E + + EE + + REEE R+E F+ +++ +L+ L + Sbjct: 209 ESLCRELQRHNKTLKEENMQQAREEEERRKEATAHFQITLDEIQAQLEQHDIHNAKLRQE 268 Query: 381 RILEVEGFKTDIK--VLRQ-------KLKDLEQMLYKATVNARANQDLALLCEVRDSNRR 431 I E K I+ LR+ K K+L+Q L V+A+ Q L+ E + ++R Sbjct: 269 NIELGEKLKKLIEQYALREEHIDKVFKRKELQQQL----VDAKLQQTTQLIKEADEKHQR 324 >gi|58535453 CDK5 regulatory subunit associated protein 2 isoform b [Homo sapiens] Length = 1814 Score = 63.2 bits (152), Expect = 5e-10 Identities = 99/419 (23%), Positives = 177/419 (42%), Gaps = 65/419 (15%) Query: 31 QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA-------ELQKALSDMQ 83 ++K E EA + K+ ++E + LE DL+++E EIA + KA+ + Sbjct: 268 EEKERETEAAQMEHQKERNSFEERIQA---LEEDLREKEREIATEKKNSLKRDKAIQGLT 324 Query: 84 VCLFQEREHVLRLYSENDRL-----RIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHK 138 + L + + V L SE ++L + RE K + Q G++ E KE Sbjct: 325 MALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQ---GSEDYETALSGKEALSA 381 Query: 139 VTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESS-EHYQRD-------IQTLI 190 Q ++ E + S K ++S + RER E E R+ I+ L Sbjct: 382 ALRSQNLTKST-ENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLR 440 Query: 191 LQVEALQAQLGEQTKLSREQIEGLIED--RRIHLEEIQVQHQRNQNKIKELT------KN 242 +VE L+ ++ E+ K + + L+ + +++H +E ++H K++ K+ Sbjct: 441 NEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKD 500 Query: 243 LHHTQELLYESTKDFLQLRSENQNKEK---------SWMLEKDNLMSKIKQYRVQCKKKE 293 L Q+ Y + L+LRSE EK + K+ S + +Q KKE Sbjct: 501 LEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKE 560 Query: 294 DKIG----KVLPVMHESHHAQSEYIK--SLKDKLVQEKKLSNMYQEQCISLEEELARIRE 347 I K L ++ Q+E K +L+ +L Q+ YQ +LEE+++ IR Sbjct: 561 QDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVL---SYQNLRKTLEEQISEIRR 617 Query: 348 EEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQML 406 E ++ D+T+ + LE +VE F + L++K+ DL Q++ Sbjct: 618 REEESFSLYSDQTSYLS----------ICLEENNRFQVEHFSQE--ELKKKVSDLIQLV 664 Score = 43.1 bits (100), Expect = 5e-04 Identities = 74/341 (21%), Positives = 147/341 (43%), Gaps = 67/341 (19%) Query: 168 KRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKL---SREQIEGLIEDRRIHLEE 224 + R +E +EH + L ++VE+L+ +L E+ +L + + +E L E ++ Sbjct: 85 EERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQR 144 Query: 225 IQVQHQRNQNKIKELT--------KNLHHTQELLYES-----TKDFLQLRSENQNKEKSW 271 ++ ++ ++++L K++ Q L ++ T+ L+LR E++ E Sbjct: 145 VKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK 204 Query: 272 MLEKDNLMS-----------------KIKQYRVQCKKKEDKIGKVLPVMHESH------- 307 M E D M+ K K+ +QC KE+K P + S Sbjct: 205 MHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQC-LKEEKSQMACPDENVSSGELRGLC 263 Query: 308 -HAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTN--KMG 364 + E + + ++ +K N ++E+ +LEE+L RE+E REI ++ N K Sbjct: 264 AAPREEKERETEAAQMEHQKERNSFEERIQALEEDL---REKE---REIATEKKNSLKRD 317 Query: 365 KRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKA-TVNARANQDL---- 419 K +Q +T ++ E++ VE ++I+ L + L KA T + ++D Sbjct: 318 KAIQGLTMALKSKEKK----VEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETAL 373 Query: 420 ----ALLCEVRDSN----RRAHKIQGELKNLKSKVFGLENE 452 AL +R N H+++ +K + ++ L+ E Sbjct: 374 SGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQE 414 Score = 34.3 bits (77), Expect = 0.24 Identities = 22/98 (22%), Positives = 49/98 (50%), Gaps = 17/98 (17%) Query: 310 QSEYIKSLK------DKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKM 363 Q Y+K +K +++ + L N+ Q+ LEE+ ++++E+ + ++F + N Sbjct: 1176 QVRYVKHVKILGPLAPEMIDSRVLENLKQQ----LEEQEYKLQKEQNLNMQLFSEIHNLQ 1231 Query: 364 GKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKD 401 K + RY++L V+ ++ + RQ++KD Sbjct: 1232 NKFRDLSPPRYDSL-------VQSQARELSLQRQQIKD 1262 >gi|58535451 CDK5 regulatory subunit associated protein 2 isoform a [Homo sapiens] Length = 1893 Score = 63.2 bits (152), Expect = 5e-10 Identities = 99/419 (23%), Positives = 177/419 (42%), Gaps = 65/419 (15%) Query: 31 QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA-------ELQKALSDMQ 83 ++K E EA + K+ ++E + LE DL+++E EIA + KA+ + Sbjct: 268 EEKERETEAAQMEHQKERNSFEERIQA---LEEDLREKEREIATEKKNSLKRDKAIQGLT 324 Query: 84 VCLFQEREHVLRLYSENDRL-----RIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHK 138 + L + + V L SE ++L + RE K + Q G++ E KE Sbjct: 325 MALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQ---GSEDYETALSGKEALSA 381 Query: 139 VTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESS-EHYQRD-------IQTLI 190 Q ++ E + S K ++S + RER E E R+ I+ L Sbjct: 382 ALRSQNLTKST-ENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLR 440 Query: 191 LQVEALQAQLGEQTKLSREQIEGLIED--RRIHLEEIQVQHQRNQNKIKELT------KN 242 +VE L+ ++ E+ K + + L+ + +++H +E ++H K++ K+ Sbjct: 441 NEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKD 500 Query: 243 LHHTQELLYESTKDFLQLRSENQNKEK---------SWMLEKDNLMSKIKQYRVQCKKKE 293 L Q+ Y + L+LRSE EK + K+ S + +Q KKE Sbjct: 501 LEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKE 560 Query: 294 DKIG----KVLPVMHESHHAQSEYIK--SLKDKLVQEKKLSNMYQEQCISLEEELARIRE 347 I K L ++ Q+E K +L+ +L Q+ YQ +LEE+++ IR Sbjct: 561 QDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVL---SYQNLRKTLEEQISEIRR 617 Query: 348 EEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQML 406 E ++ D+T+ + LE +VE F + L++K+ DL Q++ Sbjct: 618 REEESFSLYSDQTSYLS----------ICLEENNRFQVEHFSQE--ELKKKVSDLIQLV 664 Score = 43.1 bits (100), Expect = 5e-04 Identities = 74/341 (21%), Positives = 147/341 (43%), Gaps = 67/341 (19%) Query: 168 KRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKL---SREQIEGLIEDRRIHLEE 224 + R +E +EH + L ++VE+L+ +L E+ +L + + +E L E ++ Sbjct: 85 EERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQR 144 Query: 225 IQVQHQRNQNKIKELT--------KNLHHTQELLYES-----TKDFLQLRSENQNKEKSW 271 ++ ++ ++++L K++ Q L ++ T+ L+LR E++ E Sbjct: 145 VKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK 204 Query: 272 MLEKDNLMS-----------------KIKQYRVQCKKKEDKIGKVLPVMHESH------- 307 M E D M+ K K+ +QC KE+K P + S Sbjct: 205 MHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQC-LKEEKSQMACPDENVSSGELRGLC 263 Query: 308 -HAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTN--KMG 364 + E + + ++ +K N ++E+ +LEE+L RE+E REI ++ N K Sbjct: 264 AAPREEKERETEAAQMEHQKERNSFEERIQALEEDL---REKE---REIATEKKNSLKRD 317 Query: 365 KRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKA-TVNARANQDL---- 419 K +Q +T ++ E++ VE ++I+ L + L KA T + ++D Sbjct: 318 KAIQGLTMALKSKEKK----VEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETAL 373 Query: 420 ----ALLCEVRDSN----RRAHKIQGELKNLKSKVFGLENE 452 AL +R N H+++ +K + ++ L+ E Sbjct: 374 SGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQE 414 Score = 37.7 bits (86), Expect = 0.022 Identities = 39/151 (25%), Positives = 75/151 (49%), Gaps = 18/151 (11%) Query: 66 QQREEEIAELQKALSDMQVCLFQEREHVLRLYS----ENDRLRIRELEDKKKIQNLLALV 121 + +++E +L+++LS V L EH+ R Y+ EN+RL+ E ++ Q L+ V Sbjct: 1471 RDKQKENDKLRESLSRKTVSL----EHLQREYASVKEENERLQKEGSEKERHNQQLIQEV 1526 Query: 122 GTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEH 181 E++ +E V + Q+ + + QS KA K+ + R R+ S E Sbjct: 1527 RCSGQELSRVQEE----VKLRQQLLSQNDKLLQSLRVELKAYEKLDEEH-RRLREASGEG 1581 Query: 182 YQ-----RDIQTLILQVEALQAQLGEQTKLS 207 ++ RD+ +L+++++AL+ QL + S Sbjct: 1582 WKGQDPFRDLHSLLMEIQALRLQLERSIETS 1612 Score = 34.3 bits (77), Expect = 0.24 Identities = 22/98 (22%), Positives = 49/98 (50%), Gaps = 17/98 (17%) Query: 310 QSEYIKSLK------DKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKM 363 Q Y+K +K +++ + L N+ Q+ LEE+ ++++E+ + ++F + N Sbjct: 1176 QVRYVKHVKILGPLAPEMIDSRVLENLKQQ----LEEQEYKLQKEQNLNMQLFSEIHNLQ 1231 Query: 364 GKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKD 401 K + RY++L V+ ++ + RQ++KD Sbjct: 1232 NKFRDLSPPRYDSL-------VQSQARELSLQRQQIKD 1262 >gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] Length = 1960 Score = 62.4 bits (150), Expect = 8e-10 Identities = 91/429 (21%), Positives = 183/429 (42%), Gaps = 70/429 (16%) Query: 14 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLE--LYKEACEGQH------KLECDL 65 EDR+A+ + E K +A+ + ++E ++ LE L +E + Q KLE D Sbjct: 998 EDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057 Query: 66 QQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDA 125 ++IAELQ ++++++ L ++ E ++Q LA V +A Sbjct: 1058 TDLSDQIAELQAQIAELKMQLAKKEE---------------------ELQAALARVEEEA 1096 Query: 126 GEVTYFCKEPPHKVTILQKTIQAVGECEQSE-SSAFKADPKISKRRPSRERKESSEHYQR 184 + K K+ L+ I + E +SE +S KA+ ++R E E+ + Sbjct: 1097 AQKNMALK----KIRELESQISELQEDLESERASRNKAE---KQKRDLGEELEALKTELE 1149 Query: 185 DIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLH 244 D + L+++ ++ + ++ +E E+ + H +IQ Q++ ++EL + L Sbjct: 1150 DTLDSTAAQQELRSKREQEVNILKKTLE---EEAKTHEAQIQEMRQKHSQAVEELAEQLE 1206 Query: 245 HTQEL-----------------LYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRV 287 T+ + L K LQ + ++++K K + L K + Sbjct: 1207 QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGER 1266 Query: 288 QCKKKEDKIGK-------VLPVMHESHHAQSEYIK---SLKDKLVQEKKLSNMYQEQCIS 337 + DK+ K V ++ +S S+ K +L+ +L ++L Q +S Sbjct: 1267 VRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLS 1326 Query: 338 LEEELARIREEE-GMRREIFKDRTNKMGKRLQIMTKRYEALERRRILE--VEGFKTDIKV 394 L +L ++ +E+ R ++ ++ K QI T + + ++ +E V +T +V Sbjct: 1327 LSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEV 1386 Query: 395 LRQKLKDLE 403 R+ KDLE Sbjct: 1387 KRKLQKDLE 1395 Score = 54.7 bits (130), Expect = 2e-07 Identities = 64/292 (21%), Positives = 136/292 (46%), Gaps = 24/292 (8%) Query: 173 RERKESSEHYQRDIQTLILQVEA----LQAQLGEQTKL--SREQIEGLIEDRRIHLEEIQ 226 RE++ ++E+ +++TL Q+ A LQ QL +T+L E++ + ++ LEEI Sbjct: 858 REKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEIC 917 Query: 227 VQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYR 286 + + +E ++L ++ + ++ ++ + E ++ + LEK +K+K+ Sbjct: 918 HDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLE 977 Query: 287 VQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEK---KLSNMYQEQCISLEEELA 343 + ED+ K+ +E+ +L ++ + K KL N ++ LEE Sbjct: 978 EEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEE--- 1034 Query: 344 RIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKV-LRQKLKDL 402 R+R EE R+E+ K R G + +I E++ ++K+ L +K ++L Sbjct: 1035 RLRREEKQRQELEKTRRKLEGDSTDLSD---------QIAELQAQIAELKMQLAKKEEEL 1085 Query: 403 EQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454 + L A V A Q L ++R+ + ++Q +L++ ++ E + R Sbjct: 1086 QAAL--ARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKR 1135 Score = 53.5 bits (127), Expect = 4e-07 Identities = 107/473 (22%), Positives = 194/473 (41%), Gaps = 71/473 (15%) Query: 31 QKKMAECEAENEDL--LKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDM--QVCL 86 ++ AE EA ++ L +EA E + +LE +Q E+ +L + D+ V Sbjct: 1463 ERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHE 1522 Query: 87 FQEREHVLRLYSENDRLRIRELEDKKK------------IQNLLALVGTDAGEVTYFCKE 134 ++ + L E + ++ ELED+ + +Q + A D +E Sbjct: 1523 LEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEE 1582 Query: 135 PPHKVTILQKTIQAVGECEQSESS-AFKADPKISKRRPSRERKESSEHYQRDIQTLILQV 193 ++ + ++A E E+ + S A A K+ E S + RD I Q+ Sbjct: 1583 KKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRD--EAIKQL 1640 Query: 194 EALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYES 253 LQAQ+ + RE ++D R EEI Q + N+ K+K + + QE L + Sbjct: 1641 RKLQAQMKD---CMRE-----LDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAA 1692 Query: 254 TKDFLQLRSE----------NQNKEKSWMLEKDNLMSKIKQYRVQCKKKE-------DKI 296 + Q + E + K + EK L ++I Q + ++++ D++ Sbjct: 1693 ERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRL 1752 Query: 297 GKV--------LPVMHESHHAQ---------SEYIKSLKDKLVQ-EKKLSNMYQEQCISL 338 K + E HAQ K LK KL + E + + Y+ +L Sbjct: 1753 KKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITAL 1812 Query: 339 EEELARIREE---EGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVL 395 E ++A++ E+ E R+ + + K+L+ + + + ERR E +K Sbjct: 1813 EAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDD-ERR---NAEQYKDQADKA 1868 Query: 396 RQKLKDLEQMLYKATVNA-RANQD-LALLCEVRDSNRRAHKIQGELKNLKSKV 446 +LK L++ L +A A RAN L E+ D+ A + E+ +LK+K+ Sbjct: 1869 STRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921 Score = 50.4 bits (119), Expect = 3e-06 Identities = 99/467 (21%), Positives = 203/467 (43%), Gaps = 65/467 (13%) Query: 23 SKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAE-------- 74 ++EL K E E DL ++E +E C+ + +QQ +E+ E Sbjct: 899 AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESA 958 Query: 75 -----LQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVT 129 L+K ++ ++ +E + +L +N +L ++KK +++ +A E T Sbjct: 959 RQKLQLEKVTTEAKLKKLEEEQIILE--DQNCKL----AKEKKLLEDRIA-------EFT 1005 Query: 130 YFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKE---SSEHYQRDI 186 E K L K +++ A D + RR ++R+E + + D Sbjct: 1006 TNLTEEEEKSKSLAKL--------KNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057 Query: 187 QTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHT 246 L Q+ LQAQ+ E K+ + E ++ +EE Q KI+EL + Sbjct: 1058 TDLSDQIAELQAQIAE-LKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISEL 1116 Query: 247 QELLYESTKDFLQLRSENQNKEKSWMLE------KDNLMSKIKQYRVQCKKKEDK--IGK 298 QE L ++ + ++E Q ++ LE +D L S Q ++ K++++ + K Sbjct: 1117 QEDL--ESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKK 1174 Query: 299 VLPVMHESHHAQ--------SEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEG 350 L ++H AQ S+ ++ L ++L Q K++ ++ +LE E + E Sbjct: 1175 TLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVK 1234 Query: 351 MRREIFKDRTNKMGK---RLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLY 407 + + D +K K +LQ + ++ ER R E+ T ++V +L ++ +L Sbjct: 1235 VLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVR-TELADKVTKLQV---ELDNVTGLLS 1290 Query: 408 KA-TVNARANQDL-ALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 452 ++ + +++ +D AL +++D+ + + +L +K+ +E+E Sbjct: 1291 QSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDE 1337 Score = 29.3 bits (64), Expect = 7.7 Identities = 29/126 (23%), Positives = 56/126 (44%), Gaps = 21/126 (16%) Query: 332 QEQCISLEEELARIREE----EGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEG 387 +E+ ++ EEEL ++RE+ E E+ ++ M ++LQ+ E L+ L E Sbjct: 844 EEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQ----EQLQAETELCAEA 899 Query: 388 FKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVF 447 + + L K ++LE++ + L V + R +Q E K ++ + Sbjct: 900 EELRAR-LTAKKQELEEICHD------------LEARVEEEEERCQHLQAEKKKMQQNIQ 946 Query: 448 GLENEL 453 LE +L Sbjct: 947 ELEEQL 952 >gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo sapiens] Length = 1937 Score = 62.4 bits (150), Expect = 8e-10 Identities = 90/440 (20%), Positives = 181/440 (41%), Gaps = 54/440 (12%) Query: 14 EDRLAKLHPSKELL-EYYQKKMAECEAENEDL------LKKLELYKEACEG--------- 57 ++ +AKL K+ L E +Q+ + + +AE + + KLE + EG Sbjct: 989 DETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLR 1048 Query: 58 ------QHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDK 111 + KLE DL+ +E +++ + L ++ + L S+ + + E++ + Sbjct: 1049 MDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQ 1108 Query: 112 KKIQNLLALV---GTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISK 168 KKI+ L A + G + + + + L + ++ + E + A A +++K Sbjct: 1109 KKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNK 1168 Query: 169 RRPSRERKESSEHYQRDIQTLILQVEAL-----------QAQLGEQTKLSREQIEGLIED 217 +R + +K +RD++ LQ EA+ A+LGEQ + ++++ +E Sbjct: 1169 KREAEFQK-----LRRDLEEATLQHEAMVAALRKKHADSMAELGEQID-NLQRVKQKLEK 1222 Query: 218 RRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDN 277 + L+ N I + NL L + + E Q ++ Sbjct: 1223 EKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRAR 1282 Query: 278 LMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCIS 337 L ++ +Y Q +K+ + + + S A ++ I+ LK +L +E K N S Sbjct: 1283 LQTEAGEYSRQLDEKDALVSQ----LSRSKQASTQQIEELKHQLEEETKAKNALAHALQS 1338 Query: 338 LEEELARIR---EEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKV 394 + +R EEE + + +K + +YE +R E+E K K Sbjct: 1339 SRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK---KK 1395 Query: 395 LRQKLKDLEQMLYKATVNAR 414 L Q+L++ E+ + VNA+ Sbjct: 1396 LAQRLQEAEE--HVEAVNAK 1413 Score = 53.5 bits (127), Expect = 4e-07 Identities = 92/462 (19%), Positives = 191/462 (41%), Gaps = 65/462 (14%) Query: 19 KLHPSKELLEYYQKKMAECEAENEDLLKKL-ELYKEACEGQ---HKLECDLQQREEEIAE 74 +L K + E ++ EN++L +++ +L ++ EG H+LE +Q E+E E Sbjct: 1483 ELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCE 1542 Query: 75 LQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKE 134 +Q AL + + L E +LR+ E ++++ EV E Sbjct: 1543 IQAALEEAEASLEHEEGKILRIQLELNQVK---------------------SEVDRKIAE 1581 Query: 135 PPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVE 194 ++ L++ V E QS D +I R + K+ E D+ + +Q+ Sbjct: 1582 KDEEIDQLKRNHTRVVETMQS-----TLDAEIRSRNDALRVKKKME---GDLNEMEIQLN 1633 Query: 195 ALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYEST 254 +L ++ + +G++++ ++HL++ R Q +KE + LL Sbjct: 1634 HAN-RLAAESLRNYRNTQGILKETQLHLDDA----LRGQEDLKEQLAIVERRANLLQAEI 1688 Query: 255 KDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQ-------CKKKEDKI----GKVLPVM 303 ++ + + K E + +++ Q KK E+ + +V V+ Sbjct: 1689 EELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVI 1748 Query: 304 HESHHAQSEYIKSLKD------KLVQEKKLSNMYQEQCISLEEELA----RIREEEGMRR 353 ES +A+ + K++ D +L +E+ S + +LE+ + R+ E E + Sbjct: 1749 QESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAL 1808 Query: 354 EIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNA 413 + K + K+ R++ + E ++R V+G + +++K+L + N Sbjct: 1809 KGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKH----ERRVKELTYQTEEDRKNV 1864 Query: 414 RANQDLA--LLCEVRDSNRRAHKIQGELKNLKSKVFGLENEL 453 QDL L +V+ R+A + + + SK L++EL Sbjct: 1865 LRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHEL 1906 Score = 52.0 bits (123), Expect = 1e-06 Identities = 98/453 (21%), Positives = 190/453 (41%), Gaps = 50/453 (11%) Query: 17 LAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAE-L 75 ++K+ + + QKK+ E +A E+L +++E + + K DL + EEI+E L Sbjct: 1094 ISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERL 1153 Query: 76 QKA--LSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLL--ALVGTDAGEVTYF 131 ++A + QV L ++RE +E +LR R+LE+ + AL A + Sbjct: 1154 EEAGGATSAQVELNKKRE------AEFQKLR-RDLEEATLQHEAMVAALRKKHADSMAEL 1206 Query: 132 CKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRER------------KESS 179 ++ + + QK + E + ISK + + E+ K Sbjct: 1207 GEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKE 1266 Query: 180 EHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKEL 239 E QR I L Q LQ + GE ++ E+ + L+ + Q + +++++E Sbjct: 1267 EEQQRLINDLTAQRARLQTEAGEYSRQLDEK-DALVSQLSRSKQASTQQIEELKHQLEEE 1325 Query: 240 TKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKV 299 TK + L S D LR E +E+ E +SK Q + K Sbjct: 1326 TKAKNALAHALQSSRHDCDLLR-EQYEEEQEGKAELQRALSKANSEVAQWRTK------- 1377 Query: 300 LPVMHESHHAQ-SEYIKSLKDKLVQEKKLSNMYQE----QCISLEEELARIREE-EGMRR 353 +E+ Q +E ++ K KL Q + + + E +C SLE+ R++ E E + Sbjct: 1378 ----YETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1433 Query: 354 EIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNA 413 ++ +R+N L + ++ + + E + +++ +++ + L L+K V Sbjct: 1434 DV--ERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFK--VKN 1489 Query: 414 RANQDLALLCEVRDSNRRAHKIQGELKNLKSKV 446 + L L +R N+ +Q E+ +L ++ Sbjct: 1490 VYEESLDQLETLRRENK---NLQQEISDLTEQI 1519 Score = 46.6 bits (109), Expect = 5e-05 Identities = 80/421 (19%), Positives = 181/421 (42%), Gaps = 44/421 (10%) Query: 33 KMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREH 92 K AE E E + ++ + K+ K E ++ EE++ L K +D+Q Sbjct: 844 KSAETEKEMATMKEEFQKTKDELA---KSEAKRKELEEKMVTLLKEKNDLQ--------- 891 Query: 93 VLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPH-KVTILQKTIQAVGE 151 L++ SE D L E ++ I+N + L EVT +E + K + E Sbjct: 892 -LQVQSEADSLADAEERCEQLIKNKIQL-EAKIKEVTERAEEEEEINAELTAKKRKLEDE 949 Query: 152 CEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQI 211 C + + + ++K + K ++E+ +++ + ++ A+L ++ K +E Sbjct: 950 CSELKKDIDDLELTLAK---VEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETH 1006 Query: 212 EGLIEDRRIHLEEIQV---QHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKE 268 + ++D + +++ + + + ++ +L +L ++L + + +L + + + Sbjct: 1007 QQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQ 1066 Query: 269 KSWM-LEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKL 327 +S M +E D +Q + +KKE +I S I ++D+ E +L Sbjct: 1067 ESTMDMENDK-----QQLDEKLEKKEFEI--------------SNLISKIEDEQAVEIQL 1107 Query: 328 SNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEG 387 +E +EE I E R + K R++ + + L+ +++R E +VE Sbjct: 1108 QKKIKELQARIEELGEEIEAERASRAKAEKQRSD-LSRELEEISERLEEAGGATSAQVEL 1166 Query: 388 FKTDIKVLRQKLKDLEQ--MLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSK 445 K ++ +DLE+ + ++A V A + + E+ + +++ +L+ KS+ Sbjct: 1167 NKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSE 1226 Query: 446 V 446 + Sbjct: 1227 L 1227 Score = 45.8 bits (107), Expect = 8e-05 Identities = 70/340 (20%), Positives = 140/340 (41%), Gaps = 54/340 (15%) Query: 152 CEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQI 211 CEQ + + + KI + ER E E ++ ++E E ++L ++ Sbjct: 908 CEQLIKNKIQLEAKIKE---VTERAEEEEEINAELTAKKRKLE------DECSELKKD-- 956 Query: 212 EGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSW 271 I+D + L +++ + +NK+K LT+ + E + + +K+ L+ +Q Sbjct: 957 ---IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDL 1013 Query: 272 MLEKD--NLMSKI------------------KQYRVQCKKKEDKIGKVLPVMHESHHAQS 311 E+D N+++K K+ R+ ++ + K+ L + ES Sbjct: 1014 QAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDME 1073 Query: 312 EYIKSLKDKLVQEKK-------LSNMYQEQCISLE-----EELARIREEEGMRREIFKDR 359 + L +KL EKK +S + EQ + ++ +EL EE G E + Sbjct: 1074 NDKQQLDEKL--EKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERAS 1131 Query: 360 TNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDL 419 K K+ +++ E + R LE G T +V K ++ E + + Q Sbjct: 1132 RAKAEKQRSDLSRELEEISER--LEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHE 1189 Query: 420 ALLCEVRDSNRRAHKIQGE----LKNLKSKVFGLENELRL 455 A++ +R + + GE L+ +K K+ ++EL++ Sbjct: 1190 AMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKM 1229 >gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo sapiens] Length = 1938 Score = 62.0 bits (149), Expect = 1e-09 Identities = 91/429 (21%), Positives = 193/429 (44%), Gaps = 46/429 (10%) Query: 35 AECEAENEDLLKKLELYKEAC----EGQHKLECDLQQREEEIAELQKALSDMQVCLFQER 90 A+ E + +DL LE K+ + KLE DL+ +E I +L+ ++ L ++ Sbjct: 1029 AKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKE 1088 Query: 91 EHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEV----TYFCKEPPHKVTILQKTI 146 + +L ++ D ++ L+ +KKI+ L A + E+ T K + + L + + Sbjct: 1089 FELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQR-SDLAREL 1147 Query: 147 QAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKL 206 + + E + S A A +++K+R + +K +RD++ LQ EA A L ++ Sbjct: 1148 EEISERLEEASGATSAQIEMNKKREAEFQK-----MRRDLEEATLQHEATAATLRKKQAD 1202 Query: 207 S----REQIEGLIE-DRRIHLE--EIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQ 259 S EQI+ L +++ E E++++ + I+ L+K+ + + F + Sbjct: 1203 SVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSE 1262 Query: 260 LRSENQNKEK---SWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKS 316 ++++++ + + ++K L ++ + + ++KE I + + +S A ++ ++ Sbjct: 1263 IKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQ----LTKSKQALTQQLEE 1318 Query: 317 LKDKLVQEKKLSNMYQEQCISLEEELARIR---EEEGMRREIFKDRTNKMGKRLQIMTKR 373 LK ++ +E K N S + +R EEE + + +K + + Sbjct: 1319 LKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTK 1378 Query: 374 YEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAH 433 YE +R E+E K K L Q+L++ E+ AN A L + Sbjct: 1379 YETDAIQRTEELEEAK---KKLAQRLQEAEEN------TETANSKCASL------EKTKQ 1423 Query: 434 KIQGELKNL 442 ++QGE+++L Sbjct: 1424 RLQGEVEDL 1432 Score = 53.1 bits (126), Expect = 5e-07 Identities = 82/446 (18%), Positives = 187/446 (41%), Gaps = 60/446 (13%) Query: 6 ESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDL 65 E+ L E+R L SK LLE K++ E E E++ +L K Sbjct: 898 ETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKK------------- 944 Query: 66 QQREEEIAELQKALSDMQVCL--FQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGT 123 + E++ + L++ + D+++ L ++ +H +EN K++NL + Sbjct: 945 RNLEDKCSSLKRDIDDLELTLTKVEKEKHA----TEN------------KVKNLSEEMTA 988 Query: 124 DAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQ 183 ++ KE Q+T+ + E + K + K+ ++ E E Sbjct: 989 LEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQE--- 1045 Query: 184 RDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNL 243 + L +E + +L K+S+E I L D+ ++I+ + ++ + ++ +L + Sbjct: 1046 ---KKLRADLERAKRKLEGDLKMSQESIMDLENDK----QQIEEKLKKKEFELSQLQAKI 1098 Query: 244 HHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVM 303 Q + K +L++ + E+ E L +KI++ R ++ ++I + L Sbjct: 1099 DDEQVHSLQFQKKIKELQARIEELEEEIEAE-HTLRAKIEKQRSDLARELEEISERL--- 1154 Query: 304 HESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKM 363 E+ A S I+ K + + +K+ +E + E A +R+++ D ++ Sbjct: 1155 EEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQA-------DSVAEL 1207 Query: 364 GKRLQIMTKRYEALERRRI---LEVEGFKTDIKVLRQKLKDLEQMLYK-----ATVNARA 415 G+++ + + + LE+ + +E++ ++I+ L + ++E+ + + A+ Sbjct: 1208 GEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKD 1267 Query: 416 NQDLALLCEVRDSNRRAHKIQGELKN 441 Q L+ ++ R GEL + Sbjct: 1268 EQQTQLIHDLNMQKARLQTQNGELSH 1293 Score = 52.4 bits (124), Expect = 9e-07 Identities = 79/397 (19%), Positives = 166/397 (41%), Gaps = 38/397 (9%) Query: 19 KLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKA 78 KL S+ LE QK E + + +L K Y+E + L + + +EEI++L + Sbjct: 1463 KLDESQAELEAAQK---ESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQ 1519 Query: 79 LSDMQVCLFQEREHVLRLYSEND---RLRIRELE-----DKKKIQNLLALVGTDAGEVTY 130 +++ L QE E +L + ++ + E+E ++ KI + + E+ Sbjct: 1520 IAETGKNL-QEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDR 1578 Query: 131 FCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLI 190 E ++ L++ Q E QS D +I R + K+ E D+ + Sbjct: 1579 KVIEKDEEIEQLKRNSQRAAEALQS-----VLDAEIRSRNDALRLKKKME---GDLNEME 1630 Query: 191 LQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELL 250 +Q+ Q+ E K R ++G ++D ++HL++ R+ +KE + LL Sbjct: 1631 IQLGHSNRQMAETQKHLR-TVQGQLKDSQLHLDDA----LRSNEDLKEQLAIVERRNGLL 1685 Query: 251 YESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQ 310 E + +++ + E++ L + L+ + ++ + I + + Q Sbjct: 1686 LEELE---EMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQ 1742 Query: 311 SEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIM 370 +E S+++ E+K + + EE +++E+ + +M K L+ Sbjct: 1743 AEVENSIQESRNAEEKAKKAITDAAMMAEE----LKKEQDTSAHL-----ERMKKNLEQT 1793 Query: 371 TKRYE-ALERRRILEVEGFKTDIKVLRQKLKDLEQML 406 K + L+ L ++G K I+ L ++++LE L Sbjct: 1794 VKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENEL 1830 Score = 48.5 bits (114), Expect = 1e-05 Identities = 98/477 (20%), Positives = 190/477 (39%), Gaps = 68/477 (14%) Query: 30 YQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAE-LQKA--LSDMQVCL 86 +QKK+ E +A E+L +++E K DL + EEI+E L++A + Q+ + Sbjct: 1108 FQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEM 1167 Query: 87 FQEREHVLRLYSENDRLRIRELEDKKKIQNLLA--LVGTDAGEVTYFCKEPPHKVTILQK 144 ++RE +E ++R R+LE+ A L A V ++ + + QK Sbjct: 1168 NKKRE------AEFQKMR-RDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQK 1220 Query: 145 TIQAVGECEQSESSAFKADPKISKRRPSRER------------KESSEHYQRDIQTLILQ 192 + E + +SK + + ER K E + I L +Q Sbjct: 1221 LEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQ 1280 Query: 193 VEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYE 252 LQ Q GE + E+ E LI + + Q + + +++E TK + L Sbjct: 1281 KARLQTQNGELSHRVEEK-ESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQS 1339 Query: 253 STKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSE 312 S D LR E +E+ E +SK Q + K + + E A+ Sbjct: 1340 SRHDCDLLR-EQYEEEQEAKAELQRALSKANSEVAQWRTKYET--DAIQRTEELEEAK-- 1394 Query: 313 YIKSLKDKLVQEKKLSNMYQEQCISLEEELARIR-EEEGMRREI---------------- 355 K L +L + ++ + +C SLE+ R++ E E + R++ Sbjct: 1395 --KKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRN 1452 Query: 356 -------FKDRTNKMGKRLQIMTKRYEALE----------RRRILEVEGFKTDIKVLRQK 398 +K + ++ L+ K +L + ++E + + K L+++ Sbjct: 1453 FDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEE 1512 Query: 399 LKDLEQMLYKATVNARANQDLALLCEVRDSNRRA--HKIQGELKNLKSKVFGLENEL 453 + DL + + + N + + L E S+ + +++G L++ +SK+ ++ EL Sbjct: 1513 ISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLEL 1569 Score = 41.2 bits (95), Expect = 0.002 Identities = 68/346 (19%), Positives = 149/346 (43%), Gaps = 61/346 (17%) Query: 161 KADPKISKRRPSRERKESSEHYQRDIQTLIL---QVEALQAQLGEQTKLSRE-------- 209 K D ++ + + ++ E + I++ IL +V+ L +L E+ +++ E Sbjct: 888 KNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNL 947 Query: 210 -----QIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSEN 264 ++ I+D + L +++ + +NK+K L++ + +E + + TK+ L+ + Sbjct: 948 EDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAH 1007 Query: 265 QNKEKSWMLEKDNL--------------------MSKIKQYRVQCKKKEDKIGKVLPVMH 304 Q +E+D + + + K+ R ++ + K+ L + Sbjct: 1008 QQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQ 1067 Query: 305 ES----HHAQSEYIKSLKDKLVQEKKL-SNMYQEQCISLE------EELARIRE------ 347 ES + + + + LK K + +L + + EQ SL+ E ARI E Sbjct: 1068 ESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIE 1127 Query: 348 -EEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQML 406 E +R +I K R++ + + L+ +++R E ++E K ++ +DLE+ Sbjct: 1128 AEHTLRAKIEKQRSD-LARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEAT 1186 Query: 407 YK-----ATVNARANQDLALLCEVRDSNRRA-HKIQGELKNLKSKV 446 + AT+ + +A L E D+ +R K++ E LK ++ Sbjct: 1187 LQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEI 1232 Score = 38.9 bits (89), Expect = 0.010 Identities = 59/294 (20%), Positives = 118/294 (40%), Gaps = 56/294 (19%) Query: 160 FKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRR 219 FK P + +E E ++R + L + EA + +L E++ L++++ Sbjct: 838 FKIKPLLKSAEAEKEMATMKEDFERTKEELA-RSEARRKEL-------EEKMVSLLQEKN 889 Query: 220 IHLEEIQVQHQ-RNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNL 278 ++QVQ + N +E + L ++ LL K+ + E + + +K NL Sbjct: 890 DL--QLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNL 947 Query: 279 MSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISL 338 K K+ D + L + + HA +K+L +++ +L Sbjct: 948 EDKCSSL----KRDIDDLELTLTKVEKEKHATENKVKNLSEEMT--------------AL 989 Query: 339 EEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQK 398 EE ++++ +E+ +E + + LQ+ + L K + K L Q+ Sbjct: 990 EENISKLTKEKKSLQEAHQQTLDD----LQVEEDKVNGL----------IKINAK-LEQQ 1034 Query: 399 LKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 452 DLE L Q+ L ++ + R K++G+LK + + LEN+ Sbjct: 1035 TDDLEGSL---------EQEKKLRADLERAKR---KLEGDLKMSQESIMDLEND 1076 >gi|4885583 Rho-associated, coiled-coil containing protein kinase 1 [Homo sapiens] Length = 1354 Score = 61.6 bits (148), Expect = 1e-09 Identities = 94/504 (18%), Positives = 208/504 (41%), Gaps = 68/504 (13%) Query: 14 EDRLAKLHPSKELLEY----YQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQRE 69 E ++++ K LL++ YQ+K + + ++ ++ K+ E K+ + Q Sbjct: 478 ESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLAN 537 Query: 70 EEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRI---------RELEDKKKI------ 114 E++++LQK L + L E + +RL + + REL+++ +I Sbjct: 538 EKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKS 597 Query: 115 ---------QNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGE-CEQSESSAFKADP 164 Q +L D G + + ++T LQ+ ++ + E+ E +A Sbjct: 598 QTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQD 657 Query: 165 KISKRRPSRERKESSEHYQ-RDIQTLILQV-------------------EALQAQLGEQT 204 ++ + E +Y+ + +Q + Q EA + E Sbjct: 658 MLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEME 717 Query: 205 KLSREQIEGL--IEDRRIHLEE----IQVQHQRNQNKIKELTKNLHHTQELLYESTKDFL 258 K +E+ E E+R + +E+ + V +++Q K++ LT N ++ + T L Sbjct: 718 KKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLT---L 774 Query: 259 QLRSEN------QNKEKSWMLEKDNLMSKIKQYRVQCK---KKEDKIGKVLPVMHESHHA 309 QL E+ QN+ K+ E DNL KQ + + + + + L + + + Sbjct: 775 QLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRG 834 Query: 310 QSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQI 369 ++ L+D+L E+ S +Y+ Q L+EE+ E + + ++ + +L + Sbjct: 835 NEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDL 894 Query: 370 MTKRYEALE-RRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDS 428 + E+ + R +LE + F+ + + ++ +++ K +R + ++L + + Sbjct: 895 AETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEI 954 Query: 429 NRRAHKIQGELKNLKSKVFGLENE 452 RR ++ E + + LE E Sbjct: 955 LRRENEELTEKMKKAEEEYKLEKE 978 Score = 45.4 bits (106), Expect = 1e-04 Identities = 57/248 (22%), Positives = 101/248 (40%), Gaps = 34/248 (13%) Query: 229 HQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQ 288 ++ + N K L ++L T L E + +QL+ E + K ++ ++ D +M ++ + Q Sbjct: 414 NRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQ 473 Query: 289 CKKKEDKIGKVLPVMHESHHAQSEY-----------------IKSLKDKLVQEKKLSNMY 331 + E + ++ H +EY + +LKD+L KK+S Sbjct: 474 RRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNS 533 Query: 332 Q---EQCISLEEELAR----IREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILE 384 Q E+ L+++L +R E + K T Q+ + E ER RILE Sbjct: 534 QLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILE 593 Query: 385 VEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKS 444 +TD KD Q+ +A + A + D R +Q E+K+LK Sbjct: 594 NSKSQTD--------KDYYQL--QAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKH 643 Query: 445 KVFGLENE 452 + +E E Sbjct: 644 NLEKVEGE 651 >gi|148746195 trichohyalin [Homo sapiens] Length = 1943 Score = 61.6 bits (148), Expect = 1e-09 Identities = 104/477 (21%), Positives = 199/477 (41%), Gaps = 68/477 (14%) Query: 14 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA 73 E+R +L S+E E Q+++ + E + K E +E E + K E + ++RE+E+A Sbjct: 627 EERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELA 686 Query: 74 ELQKALSDMQVCLFQEREHV--------LRLYSENDR------LRIRELEDKKKIQNLLA 119 E ++ Q RE + +L SE D R R+ E +++ Q Sbjct: 687 EEEQE---------QARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEE 737 Query: 120 LVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESS 179 E+ + +E H+ ++ + Q+E + + ++S R P RE++E Sbjct: 738 KRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRER- 796 Query: 180 EHYQRDIQTLILQVEALQAQLGEQTKL-SREQIEGLIEDRRIHLEEIQVQHQRNQNKIKE 238 Q+ A + Q EQ L E+ E RR +E+Q + Q + +E Sbjct: 797 ------------QLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRE 844 Query: 239 LTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGK 298 + L ++ L E D + RS+ Q +++ W + + + + ++++ K Sbjct: 845 RAQQLQEEEDGLQE---DQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRK 901 Query: 299 VLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKD 358 ++ E + + + QE++ Y+E+ +EE +REE RR ++ Sbjct: 902 EQQLLQEEEEELQREEREKRRRQEQERQ----YREEEQLQQEEEQLLREEREKRRRQERE 957 Query: 359 RTNKMGKRLQIMTKRY--EALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNAR-- 414 R + K+LQ ++ E E+RR E E + + L+Q + EQ+L + R Sbjct: 958 RQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQ---EEEQLLREEREKRRRQ 1014 Query: 415 ------------ANQDLALLCEVRDSNR-----RAHKIQGELKNLKSKVFGLENELR 454 ++ LL E R+ R R ++ + EL+ + ++ G E E R Sbjct: 1015 EWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETR 1071 Score = 59.7 bits (143), Expect = 5e-09 Identities = 104/476 (21%), Positives = 199/476 (41%), Gaps = 88/476 (18%) Query: 10 LPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQRE 69 L E++L P K + +KK E E E ++ +L +E E + + E + Q R+ Sbjct: 966 LQQKEEQLLGEEPEKRRRQEREKKYRE---EEELQQEEEQLLREEREKRRRQEWERQYRK 1022 Query: 70 EEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIREL---EDKKKIQNLLALVGTDAG 126 ++ ELQ QE E +LR E RL+ RE E+++ Q L+G + Sbjct: 1023 KD--ELQ-----------QEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEE-- 1067 Query: 127 EVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRER--KESSEHYQR 184 + L++ + E +Q E + +P+ +RR RER +E E Q Sbjct: 1068 -------RETRRRQELERQYRKEEELQQEEEQLLREEPE-KRRRQERERQCREEEELQQE 1119 Query: 185 DIQTLILQVE-----ALQAQLGEQTKLSREQIEGL----------------IEDRRIHLE 223 + Q L + E L+ Q E+ ++ +E+ + L E+ + E Sbjct: 1120 EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQE 1179 Query: 224 EIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIK 283 E Q+ + + + +E + +EL + K + R E+Q + W E + + ++ Sbjct: 1180 EEQLLREEQEKRRQERERQYREEEELQRQKRKQ--RYRDEDQRSDLKWQWEPEK-ENAVR 1236 Query: 284 QYRVQCKKKEDKIGKVLPVM----HESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLE 339 +V CK +E++ + L +S + +++ ++++ +++ E Sbjct: 1237 DNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEE 1296 Query: 340 EELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKL 399 E+L R ++E RR DR ++ K+L R E E+RR E + +K Sbjct: 1297 EQLEREEQKEAKRR----DRKSQEEKQL----LREEREEKRRRQETD----------RKF 1338 Query: 400 KDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRL 455 ++ EQ+L + ++ L + RD R +++ + + K LE E RL Sbjct: 1339 REEEQLL-------QEREEQPLRRQERDRKFREEELRHQEQGRKF----LEEEQRL 1383 Score = 53.1 bits (126), Expect = 5e-07 Identities = 81/379 (21%), Positives = 160/379 (42%), Gaps = 38/379 (10%) Query: 105 IRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQ-SESSAFKAD 163 +R D K + +L L+ D+ F + + Q A+G+ E + D Sbjct: 45 LRRPHDPKTVDLILELLDLDSNGRVDFNEFLLFIFKVAQACYYALGQATGLDEEKRARCD 104 Query: 164 PKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIE------- 216 K S + R+ ++ RD Q L+ E Q + ++ + RE EG + Sbjct: 105 GKESLLQDRRQEEDQRRFEPRDRQ---LEEEPGQRRRQKRQEQERELAEGEEQSEKQERL 161 Query: 217 ---DRRIHLEEIQVQHQRNQNKIKELTKNL-------HHTQELLYEST---KDFLQLRSE 263 DR+ EE+ Q Q Q + + + H T+E E ++ L+LR + Sbjct: 162 EQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRK 221 Query: 264 NQNKEKSWMLEKDNLM---SKIKQYRVQ---CKKKEDKIGKVLPVMHESHHAQSEYIKSL 317 + +++ E+ + + + K++R + +K+E+K+ + P + E ++ L Sbjct: 222 GREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKL 281 Query: 318 KDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEAL 377 + + ++ ++ Q+Q + E++L R +EEE RRE ++R + +R Q +R + L Sbjct: 282 ERQELRRERQEEEQQQQRLRREQQLRRKQEEE--RREQQEERREQQERREQQEERREQQL 339 Query: 378 ERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSN--RRAHKI 435 R E E + Q+ + EQ L + R Q L ++R RR ++ Sbjct: 340 RR----EQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQL 395 Query: 436 QGELKNLKSKVFGLENELR 454 + E + + + E +LR Sbjct: 396 RREQQLRREQQLRREQQLR 414 Score = 53.1 bits (126), Expect = 5e-07 Identities = 95/440 (21%), Positives = 184/440 (41%), Gaps = 53/440 (12%) Query: 10 LPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKL------ELYKEACEGQHKLEC 63 L E++L KL + E +++ + E L++ E +E E Q + E Sbjct: 271 LQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQ 330 Query: 64 DLQQREEEIAELQKALSDMQVCLFQE---REHVLRLYSENDRL--RIRELEDKKKIQNL- 117 ++RE+++ Q+ + Q+ QE RE LR E +R ++R + ++ Q L Sbjct: 331 QEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLR 390 Query: 118 ----LALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSR 173 L E ++ + L++ Q E E+ E K + + ++R R Sbjct: 391 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEE-ERHEQKHEQERREQRLKR 449 Query: 174 ERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQ--IEGLIEDRRIHLEEIQVQHQR 231 E++E + +R+ +T + E + QL + R + ++ E+RR E + Q +R Sbjct: 450 EQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRR 509 Query: 232 NQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNK-------EKSWMLEKDNLMSKIK- 283 Q + +E +E L + + QLR E + + E+ LE++ ++K Sbjct: 510 EQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKR 569 Query: 284 ---QYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEE 340 + R Q K+E++ + E + L+ +L +E ++ + QE+ E+ Sbjct: 570 EQEERRDQLLKREEE--------RRQQRLKREQEERLEQRLKRE-EVERLEQEE--RREQ 618 Query: 341 ELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLK 400 L R EE R+++ K + ++ Q+ ++ E E+R E E + Sbjct: 619 RLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEE------------E 666 Query: 401 DLEQMLYKATVNARANQDLA 420 LEQ L + R Q+LA Sbjct: 667 RLEQRLKREHEEERREQELA 686 Score = 52.8 bits (125), Expect = 7e-07 Identities = 87/440 (19%), Positives = 187/440 (42%), Gaps = 60/440 (13%) Query: 40 ENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSE 99 E E +++ E ++ E + +L Q+R + E ++ L + + +E + E Sbjct: 1434 EEEQQVRRQERERKFLEEEQQLR---QERHRKFREEEQLLQEREEQQLHRQERDRKFLEE 1490 Query: 100 NDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSA 159 +LR +E + K + Q L + +EP K ++ + +Q + Sbjct: 1491 EQQLRRQERDRKFREQELRS-------------QEPERKFLEEEQQLHR----QQRQRKF 1533 Query: 160 FKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRR 219 + + ++ ++ ++R++ + R+ + L Q E+ +LSR++ DR+ Sbjct: 1534 LQEEQQLRRQERGQQRRQDRDRKFREEEQL--------RQEREEQQLSRQE-----RDRK 1580 Query: 220 IHLEEIQVQHQRNQNKIKELTKNLHHT---QELLYESTKDF------LQLRSENQ----N 266 LEE +V+ Q + K E + L Q+L E + F LQ R E Q Sbjct: 1581 FRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQE 1640 Query: 267 KEKSWMLEKDNL--MSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQ- 323 +++ ++ E+ L + +Q R +K + ++L E + E + +++ Q Sbjct: 1641 RDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQL 1700 Query: 324 ---EKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALER- 379 E++ + +EQ + +E + REEE +R+E +++ + + +I+ + ER Sbjct: 1701 RRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPERE 1760 Query: 380 ----RRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKI 435 RR F+ + + LRQ+ + EQ L + + ++ L E + R + Sbjct: 1761 EQQLRRQERDRKFREE-EQLRQERE--EQQLRSQESDRKFREEEQLRQEREEQQLRPQQR 1817 Query: 436 QGELKNLKSKVFGLENELRL 455 G+ + + ++ E E RL Sbjct: 1818 DGKYRWEEEQLQLEEQEQRL 1837 Score = 51.6 bits (122), Expect = 1e-06 Identities = 101/446 (22%), Positives = 187/446 (41%), Gaps = 52/446 (11%) Query: 14 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA 73 + R + P +E E +++ E E E + L ++ +L + Q LQ+ E+ + Sbjct: 804 QQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQ------LQEEEDGLQ 857 Query: 74 ELQKALSDMQVCLFQEREHVLRLYSENDRLRIRE-LEDKKKIQNLLA----LVGTDAGEV 128 E Q+ + Q R+ R E +R R R L K +Q L L+ + E+ Sbjct: 858 EDQERRRSQE----QRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEEL 913 Query: 129 TYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQT 188 +E + Q+ E Q E + + +RR RER+ Y++D + Sbjct: 914 QREEREKRRRQE--QERQYREEEQLQQEEEQLLREEREKRRRQERERQ-----YRKD-KK 965 Query: 189 LILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQE 248 L + E L LGE+ + R Q E + + EE ++Q + Q +E K E Sbjct: 966 LQQKEEQL---LGEEPEKRRRQ-----EREKKYREEEELQQEEEQLLREEREKRRRQEWE 1017 Query: 249 LLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQ---CKKKEDKIGKVLPVMH- 304 Y KD LQ E +E+ EK L + +QYR + +++E +G+ Sbjct: 1018 RQYRK-KDELQQEEEQLLREER---EKRRLQERERQYREEEELQQEEEQLLGEERETRRR 1073 Query: 305 ---ESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTN 361 E + + E ++ +++L++E+ QE+ EE +EEE + RE +R Sbjct: 1074 QELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLRE---EREK 1130 Query: 362 KMGKRLQIMTKRYEAL--ERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDL 419 + + L+ + E + E ++L E K + L ++ ++ E++ + R Q+ Sbjct: 1131 RRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQE- 1189 Query: 420 ALLCEVRDSNRRAHKIQGELKNLKSK 445 + R R ++ + EL+ K K Sbjct: 1190 ----KRRQERERQYREEEELQRQKRK 1211 Score = 48.9 bits (115), Expect = 9e-06 Identities = 70/341 (20%), Positives = 141/341 (41%), Gaps = 63/341 (18%) Query: 14 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA 73 E L P ++ LE Q+ + + + + L ++ +L ++ Q + + D + REEE Sbjct: 1505 EQELRSQEPERKFLEEEQQLHRQ-QRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEE-- 1561 Query: 74 ELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCK 133 +L++ + Q+ QER+ RL + ++R E ++K + G+ + Sbjct: 1562 QLRQEREEQQLSR-QERDRKFRLEEQ----KVRRQEQERKFMEDEQQLRRQEGQ-QQLRQ 1615 Query: 134 EPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQV 193 E K ++ Q + E E+ + + D K + P R+E + + D + Sbjct: 1616 ERDRK---FREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREE 1672 Query: 194 EALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYES 253 E L Q GE+ +L R++ DR+ EE Q++ Q + K + + L + L Sbjct: 1673 EQL-LQEGEEQQLRRQE-----RDRKFREEEQQLRRQERERKFLQEEQQLRRQE--LERK 1724 Query: 254 TKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEY 313 ++ QLR E + ++ + + ++YR Sbjct: 1725 FREEEQLRQETEQEQ----------LRRQERYR--------------------------- 1747 Query: 314 IKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRRE 354 K+++E++L +EQ + +E + REEE +R+E Sbjct: 1748 ------KILEEEQLRPEREEQQLRRQERDRKFREEEQLRQE 1782 Score = 47.8 bits (112), Expect = 2e-05 Identities = 86/434 (19%), Positives = 182/434 (41%), Gaps = 49/434 (11%) Query: 24 KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQ 83 +E E ++ E E + L ++ +L +E Q + E L+ RE+++ Q+ + Q Sbjct: 357 EERREQQLRREQEEERREQQLRREQQLRREQ---QLRREQQLR-REQQLRREQQLRREQQ 412 Query: 84 VCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQ 143 + Q+ +L E + R + ++++ + L + + + +E + + Sbjct: 413 LRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRD--WLKREEETERHEQE 470 Query: 144 KTIQAVGECEQSESSAFKADPKISKRRPSRERKESS---EHYQRDIQTLILQVEA--LQA 198 + Q + ++ E + +RR +ER+E E +R Q L Q E LQ Sbjct: 471 RRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQ 530 Query: 199 QLGEQTKLSREQIEGLIEDRRIHL----EEIQVQHQRNQNKIKELTKNLHHTQELLYEST 254 +L + +L REQ E+RR L EE +++ +R + ++K E Sbjct: 531 RLRSEQQLRREQ-----EERREQLLKREEEKRLEQERREQRLKREQ-----------EER 574 Query: 255 KDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYI 314 +D L R E + +++ +++ L ++K+ V+ ++E++ + L + + + Sbjct: 575 RDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLL 634 Query: 315 KSLKDKLVQEKKLSNMYQEQCIS----------LEEELARIREEEGMRREIFKDRTNKMG 364 KS + + ++++L QE+ LE+ L R EEE +E+ ++ + Sbjct: 635 KSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR 694 Query: 365 KRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCE 424 +R++ +++ LE E KV + K Q + R ++ L + Sbjct: 695 ERIKSRIPKWQWQ-----LESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQ 749 Query: 425 VRDSNRRAHKIQGE 438 RAH+ Q E Sbjct: 750 ---EEERAHRQQQE 760 Score = 46.2 bits (108), Expect = 6e-05 Identities = 100/460 (21%), Positives = 193/460 (41%), Gaps = 63/460 (13%) Query: 22 PSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD---------LQQREEEI 72 P +E LE ++K A+ K+L L +E E + + E D LQ+REE+ Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQL-LREEREEKRRRQETDRKFREEEQLLQEREEQP 1352 Query: 73 AELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDK--KKIQNLLALVGTDAGEVTY 130 Q+ + + +E + E RLR +E E K K+ Q L Sbjct: 1353 LRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLR------------ 1400 Query: 131 FCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISK-----RRPSRERKESSEHYQ-R 184 C+E + L++ E+ + S + D K + RR RERK E Q R Sbjct: 1401 -CQEREQQ---LRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLR 1456 Query: 185 DIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLH 244 + + E Q E+ +L R++ DR+ EE Q++ Q K +E Sbjct: 1457 QERHRKFREEEQLLQEREEQQLHRQE-----RDRKFLEEEQQLRRQERDRKFRE------ 1505 Query: 245 HTQEL-LYESTKDFLQLRSE--NQNKEKSWMLEKDNLMSKIKQYRVQCKK--KEDKIGKV 299 QEL E + FL+ + Q +++ ++ E+ L +Q R Q ++ ++ K + Sbjct: 1506 --QELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLR---RQERGQQRRQDRDRKFREE 1560 Query: 300 LPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDR 359 + E Q + + ++E+K+ QE+ +E+ ++R +EG ++++ ++R Sbjct: 1561 EQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQ--QLRRQEG-QQQLRQER 1617 Query: 360 TNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLK-----DLEQMLYKATVNAR 414 K + Q++ +R E R+ + + + + ++ RQ+ + D ++ + + Sbjct: 1618 DRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQ 1677 Query: 415 ANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454 ++ L + RD R + Q + + K E +LR Sbjct: 1678 EGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLR 1717 Score = 44.7 bits (104), Expect = 2e-04 Identities = 84/422 (19%), Positives = 185/422 (43%), Gaps = 43/422 (10%) Query: 38 EAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLY 97 E +E+ L++ EL + +G+ + + ++R++ + + ++ +++RE VLR Sbjct: 203 EFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKE------WRKRETVLR-- 254 Query: 98 SENDRLRIRELEDKKKIQNLLA-LVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSE 156 E ++L+ E + ++++Q L + E+ +E + L++ Q + E+ Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER 314 Query: 157 SSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIE 216 + + +RR +E + + + + Q+ Q + + +L REQ E Sbjct: 315 REQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ----EE 370 Query: 217 DRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKD 276 +RR + Q +R Q +E + L Q+L E QLR E Q + + + + Sbjct: 371 ERREQQLRREQQLRREQQLRRE--QQLRREQQLRREQ-----QLRREQQLRREQQLRREQ 423 Query: 277 NLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCI 336 L + ++ R + K ++++ + L E +D L +E++ QE+ Sbjct: 424 QLRREQEEERHEQKHEQERREQRLKREQEER----------RDWLKREEETERHEQER-- 471 Query: 337 SLEEELARIREEEGMRREI---FKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIK 393 +++L R +EEE R + ++R + +R Q + + E +R+ E + + Sbjct: 472 -RKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQE----EEE 526 Query: 394 VLRQKLKDLEQMLYKATVNARANQDLALLCEVR-DSNRRAHKIQGELKNLKSKVFGLENE 452 L+Q+L+ +Q+ + R Q L E R + RR +++ E + + ++ E E Sbjct: 527 RLQQRLRSEQQL--RREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEE 584 Query: 453 LR 454 R Sbjct: 585 RR 586 Score = 42.4 bits (98), Expect = 9e-04 Identities = 61/341 (17%), Positives = 144/341 (42%), Gaps = 43/341 (12%) Query: 31 QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQER 90 ++K+ E E + + + +L ++ EGQ +L Q+R+ + E ++ L + + + Sbjct: 1585 EQKVRRQEQERKFMEDEQQLRRQ--EGQQQLR---QERDRKFREDEQLLQEREEQQLHRQ 1639 Query: 91 EHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVG 150 E + E +LR +E E + + + ++ Q + Sbjct: 1640 ERDRKFLEEEPQLRRQEREQQLRHD----------------------RDRKFREEEQLLQ 1677 Query: 151 ECEQSESSAFKADPKISK-----RRPSRERKESSEHYQ---RDIQTLILQVEALQAQLGE 202 E E+ + + D K + RR RERK E Q ++++ + E L+ + + Sbjct: 1678 EGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQ 1737 Query: 203 QTKLSREQIEGLIEDRRIH--LEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQL 260 + +E+ ++E+ ++ EE Q++ Q K +E + +E S + + Sbjct: 1738 EQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKF 1797 Query: 261 RSENQ----NKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMH--ESHHAQSEYI 314 R E Q +E+ ++ + + ++ ++Q +++E ++ + + E A E Sbjct: 1798 REEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKS 1857 Query: 315 KSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREI 355 + + +L QE++ + + EE + R ++EE R++ Sbjct: 1858 RREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQV 1898 Score = 38.5 bits (88), Expect = 0.013 Identities = 73/378 (19%), Positives = 154/378 (40%), Gaps = 39/378 (10%) Query: 24 KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQ 83 +E E K+ E E + L + +L +E E + +L L++ EE+ E ++ ++ Sbjct: 512 EERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL---LKREEEKRLEQERREQRLK 568 Query: 84 VCLFQEREHVLRLYSENDRLRIRE-----LEDKKKIQNLLALVGTDAGEVTYFCKEPPHK 138 + R+ +L+ E + R++ LE + K + + L + E +EP Sbjct: 569 REQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEE- 627 Query: 139 VTILQKTIQAVGECEQSESSAFKADPKISKRRPSR-ERKESSEHYQRDIQTLILQVEALQ 197 ++ Q + EQ E + + +RR R +R+E E ++ ++ + Q Sbjct: 628 ----ERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQ 683 Query: 198 AQLGEQTKLSREQIEGLIEDRRIHLEE----------IQVQHQRNQNKIKELTKNLHHTQ 247 E+ + +RE+I+ I + LE + + Q Q + +E + + Sbjct: 684 ELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRE 743 Query: 248 ELLY--ESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHE 305 L E + Q + E Q ++ +W + + + +Q R+ + P + E Sbjct: 744 SELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQ-RLSAR----------PPLRE 792 Query: 306 SHHAQ--SEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKM 363 Q +E + + + + E++ + Q E+EL + EEE ++R + + Sbjct: 793 QRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEE 852 Query: 364 GKRLQIMTKRYEALERRR 381 LQ +R + E+RR Sbjct: 853 EDGLQEDQERRRSQEQRR 870 >gi|148762940 DVL-binding protein DAPLE [Homo sapiens] Length = 2028 Score = 61.6 bits (148), Expect = 1e-09 Identities = 104/453 (22%), Positives = 194/453 (42%), Gaps = 67/453 (14%) Query: 33 KMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCL--FQER 90 K+++ E E L + LE KE E KLE +LQ+ +EE L + ++ ++ + Sbjct: 605 KLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEAL 664 Query: 91 EHVLR-LYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAV 149 EH + L EN LR + L+ + + L + D ++ E V ++ T + Sbjct: 665 EHESQGLQLENRTLR-KSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKL 723 Query: 150 GECEQSES-------------SAFKADPKISKRRPSRERKESSEH--YQRDIQTLILQVE 194 + E+ KA K S+R + S+E+ Q+ +++ + + Sbjct: 724 AQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQ 783 Query: 195 ALQAQLG-------------EQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTK 241 L+++LG E +L+ Q+EG +DR+ LE+ Q ++++ +++ K Sbjct: 784 TLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKA-LEQEVAQLEKDKKLLEKEAK 842 Query: 242 NLHHTQEL----LYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIG 297 L EL L +ST + E++ +K +D K+K + +K + Sbjct: 843 RLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRD-AAGKLK----ELEKDNRDLT 897 Query: 298 KVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFK 357 K + V HA++ + +L++ LV EK S + L +EL E+ G+ RE+ Sbjct: 898 KQVTV-----HART--LTTLREDLVLEKLKSQQLSSELDKLSQEL----EKVGLNRELLL 946 Query: 358 DRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLE-QMLYKATVNARAN 416 + +Y+ LE R KT + + +K+ LE QM KA++N + Sbjct: 947 QEDDSGS------DTKYKILEGR---NESALKTTLAMKEEKIVLLEAQMEEKASLNRQLE 997 Query: 417 QDLALL---CE-VRDSNRRAHKIQGELKNLKSK 445 +L +L CE +R + +Q K+ K Sbjct: 998 SELQMLKKECETLRQNQGEGQHLQNSFKHPAGK 1030 Score = 58.2 bits (139), Expect = 2e-08 Identities = 110/473 (23%), Positives = 199/473 (42%), Gaps = 82/473 (17%) Query: 12 SPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEE 71 S + + L + +LE K E E EN L KK+E + E + + DL+ EE Sbjct: 474 SLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEE 533 Query: 72 -IAELQKALSDMQVC----------LFQEREHVLR-LYSENDRLRI---RELEDKKKIQN 116 I E ++ SDM+ L QE++H+ R ++S +R ++ ++D +K Sbjct: 534 LIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENK 593 Query: 117 LLALVGTDA-GEVTYF-------------CKEPPHKVTILQKTIQAVGECEQSESSAFKA 162 L T+A G+++ KE + L++ +Q + Q E+ + Sbjct: 594 ALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRL----QEENG--RL 647 Query: 163 DPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHL 222 K++ + E+ E+ EH + +Q L+ L+ L +S Q+EGL D + Sbjct: 648 ARKVTSLETATEKVEALEHESQGLQ---LENRTLRKSLDTLQNVSL-QLEGLERDNK--- 700 Query: 223 EEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKI 282 Q +++ L + + T STK Q+ ENQ E+ EK+ L + Sbjct: 701 -----QLDAENLELRRLVETMRFT------STK-LAQMERENQQLER----EKEELRKNV 744 Query: 283 KQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEEL 342 + KK E L + ++S S ++ +Q+ S+ ++ Q +LE EL Sbjct: 745 DLLKALGKKSER-----LELSYQS--------VSAENLRLQQSLESSSHKTQ--TLESEL 789 Query: 343 ARIR-EEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKD 401 + E + +RR++ + +L+ K +ALE+ EV + D K+L ++ K Sbjct: 790 GELEAERQALRRDL--EALRLANAQLEGAEKDRKALEQ----EVAQLEKDKKLLEKEAKR 843 Query: 402 LEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454 L Q + +A + A L V +R K ++ K+ LE + R Sbjct: 844 LWQQV--ELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNR 894 Score = 55.8 bits (133), Expect = 8e-08 Identities = 87/408 (21%), Positives = 168/408 (41%), Gaps = 50/408 (12%) Query: 19 KLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKA 78 KLH +++Y+ +M E +N L++ + +E + + E+E +L+ Sbjct: 338 KLHD----VDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSK 393 Query: 79 LSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHK 138 L D+++ +++ + L EN L I + + + +L E+ K Sbjct: 394 LHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHL-------GWELEQLSKNADLS 446 Query: 139 VTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQA 198 + + + EC A +I K + +S+ RD +L+L+ L+ Sbjct: 447 DASRKSFVFELNEC---------ASSRILKLEKENQSLQSTIQGLRD-ASLVLEESGLKC 496 Query: 199 QLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFL 258 GE K Q+ IE + LE + Q NQ+ ++ L++ L +E L D Sbjct: 497 --GELEK-ENHQLSKKIEKLQTQLER---EKQSNQD-LETLSEELIREKEQL---QSDME 546 Query: 259 QLRSENQNKEKSWMLEKDNLMSKIKQYRVQCK-------KKEDKIGKVLPVMHESHHAQS 311 L+++ + K EKD+L + R + + K +K K L + + Sbjct: 547 TLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKL 606 Query: 312 EYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMT 371 ++ K +L ++ + + E+ LE EL R++EE G R + L+ T Sbjct: 607 SQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENG--------RLARKVTSLETAT 658 Query: 372 KRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDL 419 ++ EALE E +G + + + LR+ L L+ + + R N+ L Sbjct: 659 EKVEALEH----ESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQL 702 Score = 42.0 bits (97), Expect = 0.001 Identities = 71/344 (20%), Positives = 135/344 (39%), Gaps = 39/344 (11%) Query: 24 KELLEYYQKKMAECEAENEDLLKKLELYKEACE--------GQHKLECDLQQREEEIAEL 75 +E + + +M E + N L +L++ K+ CE GQH + A Sbjct: 976 EEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASH 1035 Query: 76 Q------KALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVT 129 Q + + L + ++ + L N L+ + K+++Q+L T + ++ Sbjct: 1036 QGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQIL 1095 Query: 130 YFCKEPP----HKVTILQKT--IQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQ 183 K+ H T+ +T +Q S+S+A A + + + + E+ E Q Sbjct: 1096 TLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETEN-ESLQ 1154 Query: 184 RDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNL 243 R + L EAL E + L E + E + QH + +K L +NL Sbjct: 1155 RQQEQLTAAYEALLQD--------HEHLGTLHERQSAEYEALIRQH----SCLKTLHRNL 1202 Query: 244 HHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVM 303 + L E D L+ ++E + +EK E++ L + + + + + G++ V Sbjct: 1203 ELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVN 1262 Query: 304 HESHHAQSEY------IKSLKDKLVQEKKLSNMYQEQCISLEEE 341 H + EY K LK L + N +Q + L+E+ Sbjct: 1263 FLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQ 1306 Score = 33.9 bits (76), Expect = 0.31 Identities = 62/349 (17%), Positives = 145/349 (41%), Gaps = 22/349 (6%) Query: 20 LHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQ--K 77 L S + + ++ E EAE + L + LE + A E D + E+E+A+L+ K Sbjct: 775 LESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDK 834 Query: 78 ALSDMQVCLFQEREHVLRLYSENDRLRIRELE-DKKKIQNLLALVGTDAGEVTYFCKEP- 135 L + + ++ + ++ ++ +E + + + LA AG++ K+ Sbjct: 835 KLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNR 894 Query: 136 --PHKVTILQKTIQAVGE--------CEQSESSAFKADPKISKRRPSRERKESSEHYQRD 185 +VT+ +T+ + E +Q S K ++ K +RE + D Sbjct: 895 DLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSD 954 Query: 186 IQTLILQVEALQAQLGEQTKLSREQI---EGLIEDRRIHLEEIQVQHQRNQNKIKELTKN 242 + IL+ ++ L + E+I E +E++ +++ + Q + + + L +N Sbjct: 955 TKYKILEGRN-ESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQN 1013 Query: 243 LHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMS--KIKQYRVQCKKKEDKIGKVL 300 Q L + + +Q KE K+ M ++K ++ ++ + Sbjct: 1014 QGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEK 1073 Query: 301 PVMHES-HHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREE 348 ++ E H +++ + + +++ +K S QE +L+ + A+++ E Sbjct: 1074 QLLKEQLQHLETQNV-TFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVE 1121 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.314 0.130 0.352 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,202,688 Number of Sequences: 37866 Number of extensions: 741422 Number of successful extensions: 6849 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 126 Number of HSP's successfully gapped in prelim test: 763 Number of HSP's that attempted gapping in prelim test: 3951 Number of HSP's gapped (non-prelim): 2378 length of query: 456 length of database: 18,247,518 effective HSP length: 106 effective length of query: 350 effective length of database: 14,233,722 effective search space: 4981802700 effective search space used: 4981802700 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (22.0 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.