Guide to the Human Genome
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Search of human proteins with 194306658

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|194306658 coiled-coil domain containing 77 isoform b [Homo
sapiens]
         (456 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|194306660 coiled-coil domain containing 77 isoform b [Homo sa...   896   0.0  
gi|194306658 coiled-coil domain containing 77 isoform b [Homo sa...   896   0.0  
gi|14150165 coiled-coil domain containing 77 isoform a [Homo sap...   896   0.0  
gi|194306535 coiled-coil domain containing 77 isoform b [Homo sa...   896   0.0  
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    74   4e-13
gi|34577114 cytomatrix protein p110 [Homo sapiens]                     72   1e-12
gi|16262452 cingulin [Homo sapiens]                                    69   7e-12
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             67   3e-11
gi|38044112 restin isoform b [Homo sapiens]                            67   3e-11
gi|4506751 restin isoform a [Homo sapiens]                             67   3e-11
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...    66   6e-11
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    65   1e-10
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    65   1e-10
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     65   1e-10
gi|21735548 centrosomal protein 2 [Homo sapiens]                       65   1e-10
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi...    65   1e-10
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    64   3e-10
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    64   3e-10
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]         64   4e-10
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]         64   4e-10
gi|71061468 centromere protein E [Homo sapiens]                        64   4e-10
gi|8922940 gamma-taxilin [Homo sapiens]                                64   4e-10
gi|58535453 CDK5 regulatory subunit associated protein 2 isoform...    63   5e-10
gi|58535451 CDK5 regulatory subunit associated protein 2 isoform...    63   5e-10
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     62   8e-10
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...    62   8e-10
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    62   1e-09
gi|4885583 Rho-associated, coiled-coil containing protein kinase...    62   1e-09
gi|148746195 trichohyalin [Homo sapiens]                               62   1e-09
gi|148762940 DVL-binding protein DAPLE [Homo sapiens]                  62   1e-09

>gi|194306660 coiled-coil domain containing 77 isoform b [Homo
           sapiens]
          Length = 456

 Score =  896 bits (2316), Expect = 0.0
 Identities = 456/456 (100%), Positives = 456/456 (100%)

Query: 1   MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 60
           MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK
Sbjct: 1   MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 60

Query: 61  LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 120
           LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL
Sbjct: 61  LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 120

Query: 121 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 180
           VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE
Sbjct: 121 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 180

Query: 181 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 240
           HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT
Sbjct: 181 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 240

Query: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300
           KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL
Sbjct: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300

Query: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360
           PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT
Sbjct: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360

Query: 361 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420
           NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA
Sbjct: 361 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420

Query: 421 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456
           LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC
Sbjct: 421 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456


>gi|194306658 coiled-coil domain containing 77 isoform b [Homo
           sapiens]
          Length = 456

 Score =  896 bits (2316), Expect = 0.0
 Identities = 456/456 (100%), Positives = 456/456 (100%)

Query: 1   MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 60
           MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK
Sbjct: 1   MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 60

Query: 61  LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 120
           LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL
Sbjct: 61  LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 120

Query: 121 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 180
           VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE
Sbjct: 121 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 180

Query: 181 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 240
           HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT
Sbjct: 181 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 240

Query: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300
           KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL
Sbjct: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300

Query: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360
           PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT
Sbjct: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360

Query: 361 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420
           NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA
Sbjct: 361 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420

Query: 421 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456
           LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC
Sbjct: 421 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456


>gi|14150165 coiled-coil domain containing 77 isoform a [Homo
           sapiens]
          Length = 488

 Score =  896 bits (2316), Expect = 0.0
 Identities = 456/456 (100%), Positives = 456/456 (100%)

Query: 1   MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 60
           MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK
Sbjct: 33  MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 92

Query: 61  LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 120
           LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL
Sbjct: 93  LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 152

Query: 121 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 180
           VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE
Sbjct: 153 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 212

Query: 181 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 240
           HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT
Sbjct: 213 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 272

Query: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300
           KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL
Sbjct: 273 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 332

Query: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360
           PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT
Sbjct: 333 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 392

Query: 361 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420
           NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA
Sbjct: 393 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 452

Query: 421 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456
           LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC
Sbjct: 453 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 488


>gi|194306535 coiled-coil domain containing 77 isoform b [Homo
           sapiens]
          Length = 456

 Score =  896 bits (2316), Expect = 0.0
 Identities = 456/456 (100%), Positives = 456/456 (100%)

Query: 1   MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 60
           MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK
Sbjct: 1   MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 60

Query: 61  LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 120
           LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL
Sbjct: 61  LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 120

Query: 121 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 180
           VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE
Sbjct: 121 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 180

Query: 181 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 240
           HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT
Sbjct: 181 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 240

Query: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300
           KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL
Sbjct: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300

Query: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360
           PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT
Sbjct: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360

Query: 361 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420
           NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA
Sbjct: 361 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420

Query: 421 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456
           LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC
Sbjct: 421 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 90/401 (22%), Positives = 185/401 (46%), Gaps = 37/401 (9%)

Query: 27  LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCL 86
           L Y Q  + + E E  DL+ +L           K   +L+Q    +A  QK  +D  +  
Sbjct: 134 LYYSQHAVKQLEGEARDLISRLH-------DSWKFAGELEQALSAVAT-QKKKADRYIEE 185

Query: 87  FQEREHVLRLYSENDRLRIRELEDKK-KIQNLLALVGTDAGEVTYFCKEPPHKVT----- 140
             +    L L    + +   EL++K  K+Q  L LV ++  E+    KE   K+      
Sbjct: 186 LTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLL 245

Query: 141 ILQKTIQA----VGECEQSESSAFKADPKISK--RRPSRERKESSEHYQRDIQTLILQVE 194
           + Q+ +QA    +G+  QS S+  +A  + ++   R +++++E     +  IQ    +++
Sbjct: 246 LPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQ 305

Query: 195 ALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYEST 254
             + ++ EQ +  R Q E + E       + ++  ++ + KI+EL + +H  +++  +  
Sbjct: 306 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE-KIRELEEKMHEQEKIREQEE 364

Query: 255 K--DFLQLRSENQNKE---KSWMLEKD--NLMSKIKQYRVQCKKKEDKIGKVLPVMHESH 307
           K  +  ++R + + +E   K W  E+       KI++     +++E+K+G+    M E  
Sbjct: 365 KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQE 424

Query: 308 HAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRL 367
               E  + ++    QE+K+    +EQ   + E+  +IRE+E M +E  +    + GK  
Sbjct: 425 EEMQEQEEKMRR---QEEKI----REQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMC 477

Query: 368 QIMTKRYEALERRRILEVEGFKTDIKVLRQ--KLKDLEQML 406
           +   K  E  E+ R  E +  + + K+  Q  K+++ E+M+
Sbjct: 478 EQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMM 518



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 94/464 (20%), Positives = 213/464 (45%), Gaps = 66/464 (14%)

Query: 12  SPEDRLAKLHPSKELLEYYQKKMAECEAENEDLL--KKLELYKEACEGQHKLECDLQQRE 69
           SPED     H  +E L    ++  E + +   +L  +K EL       QH ++    Q E
Sbjct: 94  SPEDEQKASHQHQEAL----RRELEAQVQTIRILTCQKTELQMALYYSQHAVK----QLE 145

Query: 70  EEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVT 129
            E  +L   L D       E E  L   +   +   R +E+  K ++ L+L   +    T
Sbjct: 146 GEARDLISRLHDSWK-FAGELEQALSAVATQKKKADRYIEELTKERDALSL---ELYRNT 201

Query: 130 YFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRR--------PSRERKESSEH 181
              +E   K   LQ+ +Q V    +SE S  + + K  KR+        P ++ +  ++H
Sbjct: 202 ITDEELKEKNAKLQEKLQLV----ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADH 257

Query: 182 YQRDIQTLILQVEALQAQLGEQTKLSREQIEGLI-EDRRIHLEEIQVQHQRNQNKIKELT 240
             +++Q++  +++A   +     +L+++Q E +  ++ +I   E ++Q Q  + KI+E  
Sbjct: 258 LGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQ--EEKIREQE 315

Query: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300
           + +   +E+++E        + E   +++  M EK+  + ++++   + +K  ++     
Sbjct: 316 EKMRRQEEMMWE--------KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQ----- 362

Query: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360
               E    + E I+  + +  QE K+    QE+ I  +EE  +IRE+E    E+ +++ 
Sbjct: 363 ----EEKRQEEEKIREQEKRQEQEAKMWR--QEEKIREQEE--KIREQE----EMMQEQE 410

Query: 361 NKMGKRLQIMTKRYEALE------RRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNAR 414
            KMG++ + M ++ E ++      RR+  ++   +  I+   +K+++ E+M+ +     +
Sbjct: 411 EKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQ--EEK 468

Query: 415 ANQDLALLCE----VRDSNRRAHKIQGELKNLKSKVFGLENELR 454
             +    +CE    +++   +  + + +++  + K+   E ++R
Sbjct: 469 MGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 512



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 75/361 (20%), Positives = 163/361 (45%), Gaps = 53/361 (14%)

Query: 10  LPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQRE 69
           LP  + +    H  KEL     K  A+ E ENE L  +L   +E  E   + E  +Q+RE
Sbjct: 246 LPQQQLQAEADHLGKELQSVSAKLQAQVE-ENE-LWNRLNQQQE--EKMWRQEEKIQERE 301

Query: 70  EEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRE---LEDKKKIQNLLALVGTDAG 126
           E+I E ++ + + +  + ++ E    ++ + +++R +E    E ++KI+ L         
Sbjct: 302 EKIQEQEEKIREQEEKMRRQEE---MMWEKEEKMRRQEEMMWEKEEKIREL--------- 349

Query: 127 EVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDI 186
                 +E  H+    Q+ I+   E  Q E    + + +  +      ++E     +  I
Sbjct: 350 ------EEKMHE----QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 399

Query: 187 QTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHT 246
           +     ++  + ++GEQ +   EQ E         ++E + + +R + KI+E  K +   
Sbjct: 400 REQEEMMQEQEEKMGEQEEKMWEQEE--------EMQEQEEKMRRQEEKIREQEKKIREQ 451

Query: 247 QELLYESTKDFLQLRSENQNKEKSWMLEKDNLMS-----------KIKQYRVQCKKKEDK 295
           +E + E  ++ +Q + E   +++  M E++  M            KI++   + +++E+K
Sbjct: 452 EEKIREQ-EEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEK 510

Query: 296 IGKVLPVMHESHHAQSEYIKSL--KDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRR 353
           I +   +M E      E  + +  +++ +QE++     QE+   + E+  R+R++E   +
Sbjct: 511 IREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE--KMREQEVRLRQQEEKMQ 568

Query: 354 E 354
           E
Sbjct: 569 E 569



 Score = 58.9 bits (141), Expect = 9e-09
 Identities = 84/406 (20%), Positives = 184/406 (45%), Gaps = 45/406 (11%)

Query: 24  KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQ 83
           K+   Y ++   E +A + +L +     +E  E   KL+  LQ  E E +E+Q  + +++
Sbjct: 177 KKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELK 236

Query: 84  VCLFQEREHVL----RLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCK---EPP 136
             L  ER  +L    +L +E D L        K++Q++ A +     E   + +   +  
Sbjct: 237 RKL--ERAKLLLPQQQLQAEADHLG-------KELQSVSAKLQAQVEENELWNRLNQQQE 287

Query: 137 HKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSR--ERKESSEHYQRDIQTLILQVE 194
            K+   ++ IQ   E  Q +    +   +  +R+     E++E     +  +     ++ 
Sbjct: 288 EKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 347

Query: 195 ALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQ----RNQNKIKELTKNLHHTQELL 250
            L+ ++ EQ K+ REQ E   E+ +I  +E + + +    R + KI+E  + +   +E++
Sbjct: 348 ELEEKMHEQEKI-REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMM 406

Query: 251 YESTKDFLQLRSENQNKEKSW-----MLEKDNLM----SKIKQYRVQCKKKEDKIGKVLP 301
            E      Q     + +EK W     M E++  M     KI++   + +++E+KI +   
Sbjct: 407 QE------QEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 460

Query: 302 VMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRR---EIFKD 358
           +M E      E    + ++  + ++     + Q   + E+  +IRE+E   R   E+ ++
Sbjct: 461 MMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQE 520

Query: 359 RTNKMGKRLQIMTKRYEAL----ERRRILEVEGFKTDIKVLRQKLK 400
           +  KM ++ + M ++ E +    E+ R  E +  + ++++ +Q+ K
Sbjct: 521 QEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEK 566


>gi|34577114 cytomatrix protein p110 [Homo sapiens]
          Length = 957

 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 105/468 (22%), Positives = 206/468 (44%), Gaps = 63/468 (13%)

Query: 31  QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQER 90
           Q K+     +N D  + +E+ KE+   + +    LQ    E+  L+  L + +  L ++ 
Sbjct: 454 QTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQT---EVDALRLRLEEKESFLNKKT 510

Query: 91  EHVLRLYSENDRL--RIRELED------------KKKIQNLLALVGTDAGEVTYFCKEPP 136
           + +  L  E   L   IR+++D            +KKI+NL   +     ++T       
Sbjct: 511 KQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVK 570

Query: 137 HKVTILQKTIQAVGECEQ--SESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVE 194
              T    T  A+   E+  SE        K  + R  RER E  E ++++ + L  +V 
Sbjct: 571 SLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVN 630

Query: 195 ALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYEST 254
           ALQA+L E+        E  + D + H   +     +  +K+K L   +   +E   E +
Sbjct: 631 ALQAELTEK--------ESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKE---ECS 679

Query: 255 KDFLQLRSENQNKEKSWMLEKDNLMSKIKQ-------YRVQCKKKEDKIGKVLPVMHESH 307
           K   QL+  +  ++ S M        +IKQ       YR +C K + ++ ++L ++ E  
Sbjct: 680 KLEAQLKKAHNIEDDSRM--NPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVE 737

Query: 308 HAQSEYIK--------SLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDR 359
           + +++  K        +L+    Q KK++N+   Q +  +++ A++ EE   R +   D 
Sbjct: 738 NEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLE-KKKNAQLLEEVRRREDSMADN 796

Query: 360 T---------NKMGKRLQIM--TKRYEALERRRILEVEGFKTDIKVLRQK-LKDLEQMLY 407
           +         N + K  Q +  TK   A  ++ + E E    ++++ R+K L+++ +M  
Sbjct: 797 SQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQ 856

Query: 408 KATVNARANQDLAL-LCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454
           +A + A + +D  + L E+  S ++  K Q E+  LK +   L ++L+
Sbjct: 857 EALLAAISEKDANIALLELSASKKK--KTQEEVMALKREKDRLVHQLK 902



 Score = 35.8 bits (81), Expect = 0.083
 Identities = 33/147 (22%), Positives = 71/147 (48%), Gaps = 13/147 (8%)

Query: 273 LEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQ 332
           L+K+ ++ K +  R+   K++      + V HE +      I++L+D+L  ++ L+++ Q
Sbjct: 190 LKKERVLRKEEAARMSVLKEQ------MRVSHEENQHLQLTIQALQDELRTQRDLNHLLQ 243

Query: 333 EQCISLEEELARIR-EEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTD 391
           ++  +   E   I   EE  RR   +   ++  K L ++ K  E +E    L +E  K  
Sbjct: 244 QESGNRGAEHFTIELTEENFRR--LQAEHDRQAKELFLLRKTLEEME----LRIETQKQT 297

Query: 392 IKVLRQKLKDLEQMLYKATVNARANQD 418
           +    + +K L +ML    + +++ +D
Sbjct: 298 LNARDESIKKLLEMLQSKGLPSKSLED 324



 Score = 31.2 bits (69), Expect = 2.0
 Identities = 30/153 (19%), Positives = 60/153 (39%), Gaps = 20/153 (13%)

Query: 294 DKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRR 353
           D+ G +    H  HH     ++ ++D  +             + L+ +L  ++ E  + R
Sbjct: 119 DQHGGLTGSSHHHHHQVPSMLRQVRDSTM-------------LDLQAQLKELQRENDLLR 165

Query: 354 EIFKDRTNKMGKRLQ-IMTKRYEALERRRILEVEG------FKTDIKVLRQKLKDLEQML 406
           +    + +K+G  +  I T     L++ R+L  E        K  ++V  ++ + L+  +
Sbjct: 166 KELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTI 225

Query: 407 YKATVNARANQDLALLCEVRDSNRRAHKIQGEL 439
                  R  +DL  L +    NR A     EL
Sbjct: 226 QALQDELRTQRDLNHLLQQESGNRGAEHFTIEL 258


>gi|16262452 cingulin [Homo sapiens]
          Length = 1203

 Score = 69.3 bits (168), Expect = 7e-12
 Identities = 95/472 (20%), Positives = 198/472 (41%), Gaps = 74/472 (15%)

Query: 42  EDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSEND 101
           +DLL+  EL +E  EG+ ++E  L+ RE E+  L+ AL +      QE EHV + Y  + 
Sbjct: 467 KDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDT 526

Query: 102 RLRIRELED--------KKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECE 153
               R ++D        + + Q + ALV     E+    +E  H  ++ QK  + +   +
Sbjct: 527 EQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATK 586

Query: 154 Q--------SESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGE-QT 204
           Q         E    +   KI   +   E+  +S    R ++ L  ++   Q +L E Q 
Sbjct: 587 QELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQA 646

Query: 205 KLSREQIEGLIEDRRI---------------HLEEIQVQHQRNQNKIKE----------- 238
           +   +++ G   DR +                LEE  +Q Q+   ++++           
Sbjct: 647 ERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMV 706

Query: 239 --------------LTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLE-KDNLMSKIK 283
                         +   L  TQE   E  +  L L  E Q KE   +++  + + ++++
Sbjct: 707 AEAEATVLGQRRAAVETTLRETQEENDEFRRRILGL--EQQLKETRGLVDGGEAVEARLR 764

Query: 284 QYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQ-EKKLSNMYQEQCISLEEEL 342
               + + ++ ++ + L    E   + +   ++L+ +L + ++ L+ + QEQ     + L
Sbjct: 765 DKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQ-----QTL 819

Query: 343 ARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDL 402
            R  EEEG +RE+ +    ++ ++ +++ +  + L +      E  K  ++ L+ +L+D 
Sbjct: 820 NRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDY 879

Query: 403 EQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454
           ++   +   +A+         + +D    A K  G L  L+ ++  L   L+
Sbjct: 880 KEKARREVADAQR--------QAKDWASEAEKTSGGLSRLQDEIQRLRQALQ 923



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 57/252 (22%), Positives = 116/252 (46%), Gaps = 31/252 (12%)

Query: 14   EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD----LQQRE 69
            +D + +L   ++ L+  Q +      + E L ++L+  ++  E + + + D    L+  E
Sbjct: 912  QDEIQRL---RQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLE 968

Query: 70   EEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNL----LALVGTDA 125
            E+++ L+  L + +  +    + V R   + D+LR   ++++   Q+L    ++L   + 
Sbjct: 969  EKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNK 1028

Query: 126  GEVTYFC-----KEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESS- 179
               T        ++P   ++ L+   Q + E  Q+E    K   + + R+  R+ KE S 
Sbjct: 1029 DLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEERE-KTVLQSTNRKLERKVKELSI 1087

Query: 180  ------EHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRN- 232
                  +H       L L+V+AL+ Q+ E    + E+IE L   R+    E++ QH+ N 
Sbjct: 1088 QIEDERQHVNDQKDQLSLRVKALKRQVDE----AEEEIERLDGLRKKAQREVEEQHEVNE 1143

Query: 233  --QNKIKELTKN 242
              Q +IK L K+
Sbjct: 1144 QLQARIKSLEKD 1155


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 110/472 (23%), Positives = 208/472 (44%), Gaps = 88/472 (18%)

Query: 24   KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD------------LQQREEE 71
            KEL    Q +M     E ++L K LE  KEA   Q KLE +            L+Q E+E
Sbjct: 895  KELKHQLQVQMENTLKEQKELKKSLEKEKEASH-QLKLELNSMQEQLIQAQNTLKQNEKE 953

Query: 72   IAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYF 131
              +LQ  +++++    Q+++ +  L  E   L+I  L+ K +++N L    T A +    
Sbjct: 954  EQQLQGNINELKQSSEQKKKQIEALQGE---LKIAVLQ-KTELENKLQQQLTQAAQELAA 1009

Query: 132  CKEPPHKVTILQ----------KTIQAVGECEQSESSAFKADPKISKRRPSRERKE--SS 179
             KE   K+++LQ          K +Q+     +SE  A + D K  + + S  +++  S+
Sbjct: 1010 EKE---KISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISN 1066

Query: 180  EHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKEL 239
             +   +   LI +++  +A L EQ    +EQ    +++R   L++IQ +    + ++   
Sbjct: 1067 RNQIGNQNKLIQELKTAKATL-EQDSAKKEQ---QLQERCKALQDIQKEKSLKEKELVNE 1122

Query: 240  TKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKV 299
               L   +E+     K+  +L  E ++ +   + E  NL    KQ  +Q  +K +  GK 
Sbjct: 1123 KSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNL-KDAKQLLIQ--QKLELQGKA 1179

Query: 300  LPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELAR--IREEEGMRREIFK 357
                            SLK  + QEK+   + ++Q    EEEL +  I +E  +  EI  
Sbjct: 1180 ---------------DSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEI-- 1222

Query: 358  DRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLR-------QKLKDLEQM----- 405
                   K  ++  K++E  E +  +++     ++  ++       +++ +LE+      
Sbjct: 1223 -------KEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLR 1275

Query: 406  ----LYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENEL 453
                + +ATV    ++  ALL        R  K +GE++ L++KV  L+ +L
Sbjct: 1276 GEIAVLEATVQNNQDERRALL-------ERCLKGEGEIEKLQTKVLELQRKL 1320



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 83/464 (17%), Positives = 193/464 (41%), Gaps = 56/464 (12%)

Query: 31  QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQER 90
           Q  + E +  +E+L K+LE Y+   + + K +  +     E+  L++ L + Q   F  +
Sbjct: 96  QASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIK 155

Query: 91  EHVLRLYSENDRLRIRELED-KKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQ----KT 145
           + +  L+ +       E+ D K K     +L      +VT   +E   + T++Q    + 
Sbjct: 156 Q-MKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTEL 214

Query: 146 IQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTK 205
           +Q  G  + +         +      + ER+  SE  + + + L  Q  + +A + +   
Sbjct: 215 LQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQL-- 272

Query: 206 LSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQ 265
             R ++    ++  ++++E+Q    + ++ + ELT+      E L +  +D+ +L  E  
Sbjct: 273 --RSELAKGPQEVAVYVQELQ----KLKSSVNELTQKNQTLTENLLKKEQDYTKLE-EKH 325

Query: 266 NKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESH---HAQSEYIKSLKDKL- 321
           N+E    + K N+ + + Q  + C++ + ++      +H  H     + E  + LK++L 
Sbjct: 326 NEES---VSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELS 382

Query: 322 ----------VQEKKLSNMYQEQ---CISLEEEL------------------ARIREEEG 350
                      + K+L    +E+    + L+ E+                   R++E+  
Sbjct: 383 EVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQ 442

Query: 351 MRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKAT 410
           +  E   D+  ++   LQ+   R E   + ++      +  +   +Q+ ++ + +    T
Sbjct: 443 LSSEKLMDKEQQVAD-LQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTT 501

Query: 411 VNAR-ANQDL-ALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 452
              R A  DL  +L ++ D +++   ++  L+  K  +  LE E
Sbjct: 502 AKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKE 545



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 79/406 (19%), Positives = 168/406 (41%), Gaps = 51/406 (12%)

Query: 73   AELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFC 132
            A+LQ  L   Q  L  +++ + ++ ++ D++  + L+DK++             ++    
Sbjct: 663  ADLQNHLDTAQNALQDKQQELNKITTQLDQVTAK-LQDKQE----------HCSQLESHL 711

Query: 133  KEPPHK-VTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLIL 191
            KE   K +++ QKT +  G+ ++ E+ + +        + S+E+       QR + T   
Sbjct: 712  KEYKEKYLSLEQKTEELEGQIKKLEADSLEV-------KASKEQALQDLQQQRQLNT--- 761

Query: 192  QVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQR--NQNKIKELTKN----LHH 245
             +E    +L +Q ++ +E +     D +   E ++   Q+   Q + K++ K     L  
Sbjct: 762  DLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQ 821

Query: 246  TQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHE 305
              ++ +E   + +Q       K K   +EK+ LM+++   + +  K  D +        +
Sbjct: 822  ETKIQHEELNNRIQTTVTELQKVK---MEKEALMTELSTVKDKLSKVSDSLKNSKSEFEK 878

Query: 306  SHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGK 365
             +      I  L+    + K    +  E  +  ++EL +  E+E       K   N M +
Sbjct: 879  ENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQE 938

Query: 366  RL---QIMTKRYEALER--------------RRILEVEGFKTDIKVLRQKLKDLEQMLYK 408
            +L   Q   K+ E  E+              ++  ++E  + ++K+   +  +LE  L +
Sbjct: 939  QLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQ 998

Query: 409  ATVNARANQDLALLCE-VRDSNRRAHKIQGELKNLKSKVFGLENEL 453
                 +A Q+LA   E +        K Q   K L+S  +G E+EL
Sbjct: 999  QL--TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESEL 1042



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 69/421 (16%), Positives = 182/421 (43%), Gaps = 24/421 (5%)

Query: 18  AKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQK 77
           A LH      +  Q +++  E     +  +L    E  E   KL+ +L + E +   L+ 
Sbjct: 337 ATLHQKDLDCQQLQSRLSASETSLHRIHVELS---EKGEATQKLKEELSEVETKYQHLKA 393

Query: 78  ALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPH 137
               +Q    ++ +H L+L SE ++L  + LE ++++      +       +    +   
Sbjct: 394 EFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQ 453

Query: 138 KVTILQKTIQAVGE-CEQSESSAFKADPKISKRRPSRERKESSEHYQ----RDIQTLILQ 192
           +V  LQ  +  + E  ++  +++ +   ++ K +   + +++ +       R+ Q     
Sbjct: 454 QVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQN---D 510

Query: 193 VEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKE---LTKNLHHTQEL 249
           +E +  Q+G++ +   + +E L++  + ++  ++ + +    KI+     T  L+  QE 
Sbjct: 511 LEQVLRQIGDKDQ-KIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEK 569

Query: 250 LYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHA 309
            +   +   QL  + +N+ +S    ++NL  ++++ +   +  +D++  +   ++E +  
Sbjct: 570 NHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQ 629

Query: 310 QSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRL-- 367
            +E  + +    +Q K  + +      +   + A ++      +   +D+  ++ K    
Sbjct: 630 LNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQ 689

Query: 368 --QIMTKRYEALERRRILE--VEGFKTDIKVLRQKLKDLEQMLYKA---TVNARANQDLA 420
             Q+  K  +  E    LE  ++ +K     L QK ++LE  + K    ++  +A+++ A
Sbjct: 690 LDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQA 749

Query: 421 L 421
           L
Sbjct: 750 L 750



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 57/301 (18%), Positives = 134/301 (44%), Gaps = 45/301 (14%)

Query: 42   EDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSEND 101
            +D  KK +  +E C+    ++ +   +E+E+   +  L++++    ++ + + +L   N+
Sbjct: 1089 QDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKL---NE 1145

Query: 102  RLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSA-- 159
             L+  +LE  K+I NL      DA            K  ++Q+ ++  G+ +  +++   
Sbjct: 1146 ELKSHKLESIKEITNL-----KDA------------KQLLIQQKLELQGKADSLKAAVEQ 1188

Query: 160  FKADPKISKRRPSRERKESSEHY---QRDIQTLILQVEALQAQLGEQTKLSREQIEGLIE 216
             K + +I K +  +E +E  + +   +  + + I + E    +  E       QI  L E
Sbjct: 1189 EKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNE 1248

Query: 217  DRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEK- 275
                +L  ++ + Q +Q ++ EL K    T +L  E     L+   +N   E+  +LE+ 
Sbjct: 1249 ----NLGTVKKEWQSSQRRVSELEK---QTDDLRGEIA--VLEATVQNNQDERRALLERC 1299

Query: 276  -------DNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLS 328
                   + L +K+ + +   +K ++    V  +  E+   Q ++ ++L  K  ++ ++ 
Sbjct: 1300 LKGEGEIEKLQTKVLELQ---RKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQ 1356

Query: 329  N 329
            N
Sbjct: 1357 N 1357


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 98/476 (20%), Positives = 204/476 (42%), Gaps = 43/476 (9%)

Query: 10   LPSPEDRLAKLHPSKELLEYYQKKMAECEAE-NEDLLKKLELYKEACEGQHKLECDLQQR 68
            L + ++ L+++   KE LE   + + E  AE +E+ +      +E     H+ E      
Sbjct: 786  LTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNML 845

Query: 69   EEEIAELQKALSDMQVCLFQEREHVLRLYS-----ENDRLRIRELEDKK-----KIQNLL 118
              ++ +L++ L+DM+    ++ E   +L       END   I ++         K+ + L
Sbjct: 846  SSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDEL 905

Query: 119  ALVGTDAGEVTYFCKEPPHKVTILQKTIQAVG-ECEQSESSAFKADPKISKRRPSRERKE 177
             L   D  E+     +     + LQK+I+ +  + EQS+  A K   K  + +   ERK 
Sbjct: 906  RLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAK---KHEEEKKELERKL 962

Query: 178  SSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHL----EEIQVQHQRNQ 233
            S    ++ ++T   Q + L+A+    T  ++ + E ++++ +  L    ++++   + N 
Sbjct: 963  SD--LEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENS 1020

Query: 234  NKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEK-----------DNLMSKI 282
              ++EL +      +     T +      E   KEK+  L              N +  +
Sbjct: 1021 GLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL 1080

Query: 283  KQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEEL 342
            K+  ++  ++ +K  ++L V ++      + I++LK    Q+ +  +  QE+ + L EEL
Sbjct: 1081 KENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEEL 1140

Query: 343  ARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKV----LRQK 398
             R R+E    +++ ++R + +  +L  M KR     +    E    +  I +    L +K
Sbjct: 1141 GRSRDEVTSHQKLEEER-SVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEK 1199

Query: 399  LKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454
              +LE++  + TV    N     L  V         ++ +   L+ KV  LE +L+
Sbjct: 1200 DAELEKLRNEVTVLRGENASAKSLHSV------VQTLESDKVKLELKVKNLELQLK 1249



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 80/409 (19%), Positives = 171/409 (41%), Gaps = 45/409 (11%)

Query: 60  KLECDLQQREEEIAELQKALS--------DMQVCLFQEREHVLRLYSENDRLRIRELEDK 111
           +LE DL  R +E+AEL++ L         DM + L QE      + S  ++L +   + +
Sbjct: 468 ELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE------ISSLQEKLEVTRTDHQ 521

Query: 112 KKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRP 171
           ++I +L    G  A E T+  KE     T  +K  +     +     A K +  +     
Sbjct: 522 REITSLKEHFG--AREETHQ-KEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWK 578

Query: 172 SRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQR 231
           S+     + H Q   +  +   + L  +  E  +L + QIE +  D +  +E +Q Q   
Sbjct: 579 SKLETAIASHQQAMEELKVSFSKGLGTETAEFAEL-KTQIEKMRLDYQHEIENLQNQQDS 637

Query: 232 NQNK-IKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCK 290
            +    KE+        +++ E       +RS+    E   ++E ++ ++K+++  ++ K
Sbjct: 638 ERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVK 697

Query: 291 KKEDKIGKVLPVMHESHHAQSEYIKSLKDKL-VQEKKLSNMYQEQCISLE--EELARIRE 347
           +        L V+    + Q++ I +   +L   E+KL ++   +  S E   E+ ++R+
Sbjct: 698 E--------LEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQ 749

Query: 348 EEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLY 407
           +         +   K  K L+I      +       E++G +  +  L++ L ++ Q   
Sbjct: 750 Q--------LEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQ--- 798

Query: 408 KATVNARANQDLALLCE-VRDSNRRAHKIQGELKNLKSKVFGLENELRL 455
              V     ++L +L E   +++  A  +Q  ++   +K+   E +  +
Sbjct: 799 ---VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNM 844


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 98/476 (20%), Positives = 204/476 (42%), Gaps = 43/476 (9%)

Query: 10   LPSPEDRLAKLHPSKELLEYYQKKMAECEAE-NEDLLKKLELYKEACEGQHKLECDLQQR 68
            L + ++ L+++   KE LE   + + E  AE +E+ +      +E     H+ E      
Sbjct: 821  LTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNML 880

Query: 69   EEEIAELQKALSDMQVCLFQEREHVLRLYS-----ENDRLRIRELEDKK-----KIQNLL 118
              ++ +L++ L+DM+    ++ E   +L       END   I ++         K+ + L
Sbjct: 881  SSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDEL 940

Query: 119  ALVGTDAGEVTYFCKEPPHKVTILQKTIQAVG-ECEQSESSAFKADPKISKRRPSRERKE 177
             L   D  E+     +     + LQK+I+ +  + EQS+  A K   K  + +   ERK 
Sbjct: 941  RLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAK---KHEEEKKELERKL 997

Query: 178  SSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHL----EEIQVQHQRNQ 233
            S    ++ ++T   Q + L+A+    T  ++ + E ++++ +  L    ++++   + N 
Sbjct: 998  SD--LEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENS 1055

Query: 234  NKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEK-----------DNLMSKI 282
              ++EL +      +     T +      E   KEK+  L              N +  +
Sbjct: 1056 GLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL 1115

Query: 283  KQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEEL 342
            K+  ++  ++ +K  ++L V ++      + I++LK    Q+ +  +  QE+ + L EEL
Sbjct: 1116 KENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEEL 1175

Query: 343  ARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKV----LRQK 398
             R R+E    +++ ++R + +  +L  M KR     +    E    +  I +    L +K
Sbjct: 1176 GRSRDEVTSHQKLEEER-SVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEK 1234

Query: 399  LKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454
              +LE++  + TV    N     L  V         ++ +   L+ KV  LE +L+
Sbjct: 1235 DAELEKLRNEVTVLRGENASAKSLHSV------VQTLESDKVKLELKVKNLELQLK 1284



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 80/409 (19%), Positives = 171/409 (41%), Gaps = 45/409 (11%)

Query: 60  KLECDLQQREEEIAELQKALS--------DMQVCLFQEREHVLRLYSENDRLRIRELEDK 111
           +LE DL  R +E+AEL++ L         DM + L QE      + S  ++L +   + +
Sbjct: 503 ELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE------ISSLQEKLEVTRTDHQ 556

Query: 112 KKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRP 171
           ++I +L    G  A E T+  KE     T  +K  +     +     A K +  +     
Sbjct: 557 REITSLKEHFG--AREETHQ-KEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWK 613

Query: 172 SRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQR 231
           S+     + H Q   +  +   + L  +  E  +L + QIE +  D +  +E +Q Q   
Sbjct: 614 SKLETAIASHQQAMEELKVSFSKGLGTETAEFAEL-KTQIEKMRLDYQHEIENLQNQQDS 672

Query: 232 NQNK-IKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCK 290
            +    KE+        +++ E       +RS+    E   ++E ++ ++K+++  ++ K
Sbjct: 673 ERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVK 732

Query: 291 KKEDKIGKVLPVMHESHHAQSEYIKSLKDKL-VQEKKLSNMYQEQCISLE--EELARIRE 347
           +        L V+    + Q++ I +   +L   E+KL ++   +  S E   E+ ++R+
Sbjct: 733 E--------LEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQ 784

Query: 348 EEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLY 407
           +         +   K  K L+I      +       E++G +  +  L++ L ++ Q   
Sbjct: 785 Q--------LEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQ--- 833

Query: 408 KATVNARANQDLALLCE-VRDSNRRAHKIQGELKNLKSKVFGLENELRL 455
              V     ++L +L E   +++  A  +Q  ++   +K+   E +  +
Sbjct: 834 ---VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNM 879


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score = 66.2 bits (160), Expect = 6e-11
 Identities = 74/389 (19%), Positives = 180/389 (46%), Gaps = 40/389 (10%)

Query: 19  KLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKL----ECDLQQREEEIAE 74
           K+   +E ++ +++K+ E E +  +  +K+   +E    Q ++    E  ++++EE + E
Sbjct: 301 KMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 360

Query: 75  LQKALSDMQVCLFQEREHVLRLYSE-NDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCK 133
            ++ +  ++  ++++ E +  L  + +++ +IRE E+K++ +                  
Sbjct: 361 KEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEE----------------- 403

Query: 134 EPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQV 193
               K+   +K  +   +  + E    + + KI ++     R+E   H Q  I+    + 
Sbjct: 404 ----KIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQ 459

Query: 194 EALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYES 253
           E  Q ++  Q +  REQ E   +  ++H +E   + ++ + K+    + +H  +E + E 
Sbjct: 460 E--QEEMWRQEEKIREQEEIWRQKEKMHEQE---KIRKQEEKVWRQEEKMHDQEEKIREQ 514

Query: 254 TKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESH--HAQS 311
            +     R E + +E+   + +     KI++     +++E+K+G+    M E      Q 
Sbjct: 515 EEKMW--RQEEKIREQEEKIREQE--EKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQE 570

Query: 312 EYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMT 371
           E I+  ++K+ ++K+     +E+    EE   +IRE+E M +E  +    +  K  +   
Sbjct: 571 EKIREQEEKIREQKEKIREQEEKIWEQEE---KIREQEEMMQEQEEKMWEQEEKMCEQEE 627

Query: 372 KRYEALERRRILEVEGFKTDIKVLRQKLK 400
           K  E  E+ R  E + ++ ++++ +Q+ K
Sbjct: 628 KMQEQEEKMRRQEEKMWEQEVRLRQQEEK 656



 Score = 62.4 bits (150), Expect = 8e-10
 Identities = 90/475 (18%), Positives = 215/475 (45%), Gaps = 65/475 (13%)

Query: 27  LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCL 86
           L Y Q  + + E E  DL+ +L           K   +L+Q    +A  QK  +D  +  
Sbjct: 146 LYYSQHAVKQLEGEARDLISRLH-------DSWKFAGELEQALSAVAT-QKKKADRYIEE 197

Query: 87  FQEREHVLRLYSENDRLRIRELEDKK-KIQNLLALVGTDAGEVTYFCKEPPHKVT----- 140
             +    L L    + +   EL++K  K+Q  L LV ++  E+    KE   K+      
Sbjct: 198 LTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLL 257

Query: 141 ILQKTIQA----VGECEQSESSAFKADPKISK--RRPSRERKESSEHYQRDIQTLILQVE 194
           + Q+ +QA    +G+  QS S+  +A  + ++   R +++++E     +  IQ    +++
Sbjct: 258 LPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQ 317

Query: 195 ALQAQLGEQTKLSREQIEGLI---------EDRRIHLEEIQVQHQRN-----------QN 234
             + ++ EQ +  REQ E +          E++    EE+  + +             + 
Sbjct: 318 EQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEE 377

Query: 235 KIKELTKNLHHTQELLYESTK----DFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCK 290
           KI+EL + +H  +++  +  K    + ++ + + Q +E     +++ +  + ++ R Q K
Sbjct: 378 KIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEK 437

Query: 291 K---KEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKL----SNMYQEQCISLEEELA 343
           K   +E+KI +   +  E    + E +   ++K+ +++++      M++++ I  +EE  
Sbjct: 438 KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKV 497

Query: 344 RIREEEGM--RREIFKDRTNKMGKRLQIMTKRYEAL--ERRRILEVEGFKTDIKVLRQKL 399
             R+EE M  + E  +++  KM ++ + + ++ E +  +  +I E E     ++   +K+
Sbjct: 498 -WRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEM---MQEQEEKM 553

Query: 400 KDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454
            + E+ + +     R  +      ++R+   +  + + +++  + K++  E ++R
Sbjct: 554 GEQEEKMQEQEKMRRQEE------KIREQEEKIREQKEKIREQEEKIWEQEEKIR 602



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 91/445 (20%), Positives = 204/445 (45%), Gaps = 75/445 (16%)

Query: 24  KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQ 83
           K+   Y ++   E +A + +L +     +E  E   KL+  LQ  E E +E+Q  + +++
Sbjct: 189 KKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELK 248

Query: 84  VCLFQEREHVL----RLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCK---EPP 136
             L  ER  +L    +L +E D L        K++Q++ A +     E   + +   +  
Sbjct: 249 RKL--ERAKLLLPQQQLQAEADHL-------GKELQSVSAKLQAQVEENELWNRLNQQQE 299

Query: 137 HKVTILQKTIQAVGE-CEQSESSAFKADPKISKRRPSRERKE------------------ 177
            K+   ++ IQ   E  ++ E    + + KI ++     R+E                  
Sbjct: 300 EKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMW 359

Query: 178 SSEHYQRDIQTLILQ----VEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQ--- 230
             E   R ++ ++ +    +  L+ ++ EQ K+ REQ E   E+ +I  +E + + +   
Sbjct: 360 EKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKI-REQEEKRQEEEKIREQEKRQEQEAKM 418

Query: 231 --------RNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSW-----MLEKDN 277
                     + KI+E  K +   +E ++E  K  ++   + Q +E+ W     + E++ 
Sbjct: 419 WRQEEKIREQEEKIREQEKKMWRQEEKIHEQEK--IREEEKRQEQEEMWRQEEKIREQEE 476

Query: 278 LMSKIKQYRVQ--CKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKL-VQEKKLSNMYQEQ 334
           +  + ++   Q   +K+E+K+ +      E  H Q E I+  ++K+  QE+K+    +EQ
Sbjct: 477 IWRQKEKMHEQEKIRKQEEKVWR----QEEKMHDQEEKIREQEEKMWRQEEKI----REQ 528

Query: 335 CISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKV 394
              + E+  +IRE+E    E+ +++  KMG++ + M ++ +   RR+  ++   +  I+ 
Sbjct: 529 EEKIREQEEKIREQE----EMMQEQEEKMGEQEEKMQEQEKM--RRQEEKIREQEEKIRE 582

Query: 395 LRQKLKDLEQMLYKATVNARANQDL 419
            ++K+++ E+ +++     R  +++
Sbjct: 583 QKEKIREQEEKIWEQEEKIREQEEM 607



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 68/356 (19%), Positives = 157/356 (44%), Gaps = 54/356 (15%)

Query: 24  KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQ 83
           +E +   ++ M E E +  +L +K+   ++  E + K + + + RE+E  + Q+A    Q
Sbjct: 362 EEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ 421

Query: 84  VCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQ 143
               +E+E  +R   +    +  ++ +++KI+                            
Sbjct: 422 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIRE--------------------------- 454

Query: 144 KTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQ 203
                  E  Q +   ++ + KI ++     +KE   H Q  I+    +V   + ++ +Q
Sbjct: 455 ------EEKRQEQEEMWRQEEKIREQEEIWRQKEKM-HEQEKIRKQEEKVWRQEEKMHDQ 507

Query: 204 TKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSE 263
            +  REQ      + ++  +E +++ Q  + KI+E  + +   +E++ E  +   +   +
Sbjct: 508 EEKIREQ------EEKMWRQEEKIREQ--EEKIREQEEKIREQEEMMQEQEEKMGEQEEK 559

Query: 264 NQNKEKSWMLEKD--NLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKL 321
            Q +EK    E+       KI++ + + +++E+KI +      E    Q E ++  ++K+
Sbjct: 560 MQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWE----QEEKIREQEEMMQEQEEKM 615

Query: 322 -VQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEA 376
             QE+K+    QE+ +  +EE  R +EE+   +E+   R  +  +++Q   +  EA
Sbjct: 616 WEQEEKMCE--QEEKMQEQEEKMRRQEEKMWEQEV---RLRQQEEKMQEHQEHLEA 666


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 96/465 (20%), Positives = 204/465 (43%), Gaps = 72/465 (15%)

Query: 12  SPEDRLAKLHPSKELLEYYQKKMAECEAENEDLL--KKLELYKEACEGQHKLECDLQQRE 69
           SPED     H  +E L    ++  E +     +L  +K EL       QH ++    Q E
Sbjct: 106 SPEDEQKASHQHQEAL----RRELEAQVHTIRILTCQKTELQMALYYSQHAVK----QLE 157

Query: 70  EEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVT 129
            E  +L   L D       E E  L   +   +   R +E+  K ++ L+L   +    T
Sbjct: 158 GEARDLISRLHDSWK-FAGELEQALSAVATQKKKADRYIEELTKERDALSL---ELYRNT 213

Query: 130 YFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRR--------PSRERKESSEH 181
              +E   K   LQ+ +Q V    +SE S  + + K  KR+        P ++ +  ++H
Sbjct: 214 ITDEELKEKNAKLQEKLQLV----ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADH 269

Query: 182 YQRDIQTLILQVEALQAQLGEQTKLSREQIEGLI-EDRRIHLEEIQVQHQRN-----QNK 235
             +++Q++  +++A   +     +L+++Q E +  ++ +I   E ++Q Q       + K
Sbjct: 270 LGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEK 329

Query: 236 IKELTKNLHHTQELLYESTK------DFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQC 289
           I+E  + +   +E+++E  +      + +  + E   +++  M EK+    K+++     
Sbjct: 330 IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE---KMRRQEEMM 386

Query: 290 KKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEE 349
            +KE+KI ++   MHE    + +  K  +++ ++E++     QEQ   +  +  +IRE+E
Sbjct: 387 WEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR---QEQEAKMWRQEEKIREQE 443

Query: 350 GMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKA 409
               E  +++  KM ++ +      +  E+ +I E E  +   ++ RQ+ K  EQ     
Sbjct: 444 ----EKIREQEKKMWRQEE------KIHEQEKIREEEKRQEQEEMWRQEEKIHEQE---- 489

Query: 410 TVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454
                         E+     + H+ + +++  + KV+  E ++R
Sbjct: 490 --------------EIWRQKEKMHEQEEKIRKQEEKVWRQEEKIR 520



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 81/388 (20%), Positives = 179/388 (46%), Gaps = 42/388 (10%)

Query: 24  KELLEYYQKKMAECEAENEDLLKKLELYK-EACEGQHKLECDLQQREEEIAELQKALSDM 82
           +E +   ++KM E E   E   K+ E  K    E + + E  + ++EE+I E ++ + + 
Sbjct: 390 EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 449

Query: 83  QVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTIL 142
           +  ++++ E +      +++ +IRE E+K++ Q           E  +  +E  H+   +
Sbjct: 450 EKKMWRQEEKI------HEQEKIRE-EEKRQEQ-----------EEMWRQEEKIHEQEEI 491

Query: 143 QKTIQAVGECEQS----ESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQA 198
            +  + + E E+     E   ++ + KI  R    + +E  E   R  + +  Q E  + 
Sbjct: 492 WRQKEKMHEQEEKIRKQEEKVWRQEEKI--REQEEKIREQEEKMWRQEEKIREQEEMWRE 549

Query: 199 Q--LGEQTKLSREQIEGLIEDRRIHLEE-IQVQHQ---RNQNKIKELTKNLHHTQELLYE 252
           +  + EQ K+  E+     ED+    EE I+ Q +   R + KI+E  +     +E +++
Sbjct: 550 EEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWK 609

Query: 253 STKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSE 312
             +   +   + Q +E+    +++    KI++     +++E+K+G+    M E      E
Sbjct: 610 QEEKIREQEEKIQEQEEKIREQEE----KIREQEEMTQEQEEKMGEQEEKMCEQEEKMQE 665

Query: 313 YIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTK 372
             +++     QE+K+    +EQ   + E+  +IRE+E M +E  +    +  K  +   K
Sbjct: 666 QEETMWR---QEEKI----REQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 718

Query: 373 RYEALERRRILEVEGFKTDIKVLRQKLK 400
             E  E+ R  E + ++ ++++ +Q+ K
Sbjct: 719 MQEQEEKMRRQEEKMWEQEVRLRQQEEK 746



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 61/333 (18%), Positives = 160/333 (48%), Gaps = 28/333 (8%)

Query: 31  QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQER 90
           ++K+ E E +  +  KK+   +E    Q K+  + +++E+E    Q+     Q  +++++
Sbjct: 436 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQK 495

Query: 91  EHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVG 150
           E   +++ + +++R +E +  ++ + +         E     +E   K+   ++ I+   
Sbjct: 496 E---KMHEQEEKIRKQEEKVWRQEEKIR--------EQEEKIREQEEKMWRQEEKIREQE 544

Query: 151 ECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQ 210
           E  + E    + + KI +    +E+++     +  I+    +V   + ++ EQ +  +EQ
Sbjct: 545 EMWREEEKMHEQE-KIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQ 603

Query: 211 IEGLI-EDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEK 269
            E +  ++ +I  +E ++Q Q  + KI+E  + +   +E+  E  +   + + E   +++
Sbjct: 604 EEKMWKQEEKIREQEEKIQEQ--EEKIREQEEKIREQEEMTQEQEEKMGE-QEEKMCEQE 660

Query: 270 SWMLEKDNLM----SKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEK 325
             M E++  M     KI++   + +++E+KI +   +M E    Q E +   ++K+ +++
Sbjct: 661 EKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQE----QEEKMWEQEEKMCEQE 716

Query: 326 KLSNMYQEQCISLEEEL----ARIREEEGMRRE 354
           +     +E+    EE++     R+R++E   +E
Sbjct: 717 EKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 92/416 (22%), Positives = 194/416 (46%), Gaps = 55/416 (13%)

Query: 14  EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA 73
           +++ AKL   +E L+  + + +E +   ++L +KLE        + KL    QQ + E  
Sbjct: 281 KEKNAKL---QEKLQLVESEKSEIQLNVKELKRKLE--------RAKLLLPQQQLQAEAD 329

Query: 74  ELQKALSDMQVCL---FQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTY 130
            L K L  +   L    +E E   RL  + +    R+ E   KIQ     +     ++  
Sbjct: 330 HLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEE---KIQEWEEKIQEQEEKI-- 384

Query: 131 FCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLI 190
             +E   K+   ++ ++   E    +    +   ++   +  + R++    ++++ +   
Sbjct: 385 --REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK--- 439

Query: 191 LQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQ----RNQNKIKELTKNLHHT 246
             +  L+ ++ EQ K+ REQ E   E+ +I  +E + + +    R + KI+E  + +   
Sbjct: 440 --IRELEEKMHEQEKI-REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 496

Query: 247 QELLY---ESTKDFLQLRSENQNKEKSWML---EKDNLMSKIKQYRVQCKKKEDKIGKVL 300
           +E ++   E   +  ++R E + +E+  M    EK     +I + + +  ++E+KI K  
Sbjct: 497 EEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQE 556

Query: 301 PVM---HESHHAQSEYIKSLKDKLV-QEKKLSNMYQEQCISLEEELARIREEEGMRREIF 356
             M    E  H Q E I+  ++K+  QE+K+    QE+ I  +EE  +IRE+E M +E  
Sbjct: 557 EKMWRQEEKMHDQEEKIREQEEKVWRQEEKIRE--QEEKIREQEE--KIREQEEMTQE-- 610

Query: 357 KDRTNKMGKRLQIMTKRYEALE------RRRILEVEGFKTDIKVLRQKLKDLEQML 406
             +  KMG++ + M ++ E ++      RR+  ++   +  I+   +K+++ E+M+
Sbjct: 611 --QEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMM 664



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 75/387 (19%), Positives = 178/387 (45%), Gaps = 41/387 (10%)

Query: 19  KLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKL----ECDLQQREEEIAE 74
           K+   +E ++ +++K+ E E +  +  +K+   +E    Q ++    E  ++++EE + E
Sbjct: 362 KMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 421

Query: 75  LQKALSDMQVCLFQEREHVLRLYSE-NDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCK 133
            ++ +   +  ++++ E +  L  + +++ +IRE E+K++ +                  
Sbjct: 422 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEE----------------- 464

Query: 134 EPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQV 193
               K+   +K  +   +  + E    + + KI ++     R+E   H Q  I+    + 
Sbjct: 465 ----KIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQ 520

Query: 194 EALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYES 253
           E  Q ++  Q +  REQ E   +  +IH +E +++ Q  + K+    + +H  +E + E 
Sbjct: 521 E--QEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQ--EEKMWRQEEKMHDQEEKIREQ 576

Query: 254 TKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEY 313
            +     R E + +E+   + +     KI++     +++E+K+G+    M E      E 
Sbjct: 577 EEKVW--RQEEKIREQEEKIREQE--EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQ 632

Query: 314 IKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKR 373
            + ++    QE+K+    +EQ   + E+  +IRE+E M +E  +    +  K  +   K 
Sbjct: 633 EEKMRR---QEEKI----REQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKM 685

Query: 374 YEALERRRILEVEGFKTDIKVLRQKLK 400
            E  E+ R  E + ++ ++++ +Q+ K
Sbjct: 686 QEQEEKMRRQEEKMWEQEVRLRQQEEK 712



 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 66/288 (22%), Positives = 125/288 (43%), Gaps = 55/288 (19%)

Query: 171 PSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSR---------EQIEGLIED--RR 219
           P  E+K S +H +   + L  QV  ++    ++T+L           +Q+EG   D   R
Sbjct: 168 PEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISR 227

Query: 220 IH------------LEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNK 267
           +H            L  +  Q ++    I+ELTK        LY +T    +L+ +N   
Sbjct: 228 LHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKL 287

Query: 268 EKSWML---EKDNLMSKIKQYR------------VQCKKKEDKIGKVLPVMHESHHAQSE 312
           ++   L   EK  +   +K+ +             Q + + D +GK L  +     AQ E
Sbjct: 288 QEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE 347

Query: 313 YIKSLKDKLVQEKKLSNMYQEQCI-----SLEEELARIRE--------EEGMRR--EIFK 357
               L ++L Q+++     QE+ I      ++E+  +IRE        EE MRR  E+  
Sbjct: 348 E-NELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMW 406

Query: 358 DRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQM 405
           ++  KM ++ ++M ++ E + R+  +  E  +  I+ L +K+ + E++
Sbjct: 407 EKEEKMRRQEEMMWEKEEKMRRQEEMMWEK-EEKIRELEEKMHEQEKI 453


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 94/437 (21%), Positives = 193/437 (44%), Gaps = 46/437 (10%)

Query: 19  KLHPSKELLEYYQKKMAECEA-------ENEDLLKKLELYKEACEGQHKLECDLQQREEE 71
           KL   ++  E Y+ ++ E E+       EN++  K L ++ EA + +H  E  +   E+ 
Sbjct: 554 KLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMV-EKH 612

Query: 72  IAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYF 131
             EL+ +L   Q  L+ E+  VL+   + +  ++RE  +++K   L          +   
Sbjct: 613 KTELE-SLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEM 671

Query: 132 CKEPPHKVTILQKTIQAVG-ECEQSESSAFKADPKIS---------KRRPSRERKESSEH 181
            ++   K+ + Q  ++++  E  +   +  K + ++S         K+    +  E   H
Sbjct: 672 NEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNH 731

Query: 182 YQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEE-------IQVQHQRNQN 234
           +Q+ + ++I + E    +  +  K    Q+E L+++R  HL+E       ++   +R++ 
Sbjct: 732 HQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEG 791

Query: 235 KIKELTKNL---HHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQ--- 288
           ++++ +  L      Q   +E TK + +  ++ Q K      E+  L  ++ +   Q   
Sbjct: 792 ELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKD 851

Query: 289 -CKKKEDKIGKVLPVMHESHHAQSEYIKSLKD-KLVQEKKL--SNMYQEQC--ISLEEEL 342
            C + +    +V  +M +     SE  + +K    V E KL   N  QEQ   I +E+E 
Sbjct: 852 VCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKEN 911

Query: 343 ARIREEEGMRREIFKDRTNKMGKR---LQIMTKRYEALERRRILEVEGFKTDIK----VL 395
             ++  EG ++EI +  T K+  +   + I+ + YE   + +  ++E  K   K     L
Sbjct: 912 MILQMREGQKKEI-EILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETL 970

Query: 396 RQKLKDLEQMLYKATVN 412
           ++KL D E  L K   N
Sbjct: 971 KKKLLDQEAKLKKELEN 987



 Score = 62.4 bits (150), Expect = 8e-10
 Identities = 100/466 (21%), Positives = 192/466 (41%), Gaps = 66/466 (14%)

Query: 10   LPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLE----LYKEACEGQ-HKLECD 64
            L + EDRL     +K L E  +K   +  A  + LL ++E     YK+  E    +L   
Sbjct: 1622 LKALEDRLESESAAK-LAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTK 1680

Query: 65   LQQREEEIAELQKAL-----SDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLA 119
            LQ+RE E+  L++ L     S  +  +       +  Y+E +    +    K   + +  
Sbjct: 1681 LQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISV 1740

Query: 120  LVGTDAGEVTYFCKEPPHKVTILQKTIQAVG-ECEQSESSAFKADPKISKRRPSRERKES 178
            L                  +T  +K +Q VG E E++ SS F+   +  +R    E  E+
Sbjct: 1741 L---------------QRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEA 1785

Query: 179  SEHYQRDI-------------QTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEI 225
             +H  + +             +  ++  + ++ + G+    +++ +E + +D +  L+E 
Sbjct: 1786 KQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEK 1845

Query: 226  QVQHQRNQNKIKEL------TKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLM 279
            ++  Q  + KIKEL       K +H  +     S  + LQ   +   + K   L ++N  
Sbjct: 1846 ELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTE 1905

Query: 280  SKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLE 339
             K K + VQ         K+L  M   H+        L+ KL   ++      ++ + L+
Sbjct: 1906 EKSKSHLVQ--------PKLLSNMEAQHN-------DLEFKLAGAEREKQKLGKEIVRLQ 1950

Query: 340  EELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKV-LRQK 398
            ++L  +R+E     EI K   ++  +R + + +  E LE +    ++    +    L QK
Sbjct: 1951 KDLRMLRKEHQQELEILKKEYDQ--EREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQK 2008

Query: 399  LKDLEQMLYKATVNARANQDLALL-CEVRDSNRRAHKIQGELKNLK 443
             ++LE M  K T+N     +  LL     ++N+   KI  +  +LK
Sbjct: 2009 EQELE-MTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLK 2053



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 102/501 (20%), Positives = 208/501 (41%), Gaps = 60/501 (11%)

Query: 2   ADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAE----NEDLLKKLELYKEACEG 57
           + S ES    S  + L +L        +      + EAE    N D L K +L +     
Sbjct: 87  SSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRM 146

Query: 58  QHKLECDLQQREEEIAE---LQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKI 114
           +  L     +  E +     LQ+    +Q  L Q ++  LR  +E       + + KK +
Sbjct: 147 ERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHL 206

Query: 115 QN-----------LLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECE---QSESSAF 160
           Q             ++++ T    +    +  P  V +L+   Q   + E   + E+   
Sbjct: 207 QEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPES 266

Query: 161 KADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLS--REQIEGLIEDR 218
             +P +      +  +   +  +R    L    E +Q+   + T L+  +E ++  +++R
Sbjct: 267 DGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDER 326

Query: 219 RIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKD-- 276
              LE+I+  H   + K+    ++  +  E L E  K  +   ++ Q  E   M E++  
Sbjct: 327 LQELEKIKDLHMAEKTKLITQLRDAKNLIEQL-EQDKGMVIAETKRQMHETLEMKEEEIA 385

Query: 277 NLMSKIKQY-------RVQCKKKE----DKIGKVLPVMHESHHAQSEYIKSLKDKLVQEK 325
            L S+IKQ        R Q +K E    +++ K L    ++  A+ + +K+  D+  Q K
Sbjct: 386 QLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRK-LKAEMDE--QIK 442

Query: 326 KLSNMYQEQCISLEEELARIREE---------EGMRREIFKDRTNKMGKRLQIMTKRYEA 376
            +    +E+ ISL++EL+R+++E         E    ++ K    ++ ++ Q +TK+ + 
Sbjct: 443 TIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQT 502

Query: 377 LERRRILEVEGFKTDIKVLRQKLKD--LEQMLYKATVNARANQDLALLCE--VRDSNRRA 432
            ER        F+  +KV  +K +   L+    K    + A ++L L  +  + +S  + 
Sbjct: 503 RERE-------FQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKL 555

Query: 433 HKIQGELKNLKSKVFGLENEL 453
             +Q E +  ++++  LE+ L
Sbjct: 556 RDLQQEAETYRTRILELESSL 576



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 95/468 (20%), Positives = 197/468 (42%), Gaps = 64/468 (13%)

Query: 49   ELYKEACEGQHKLECDLQQREEEIAELQK----------------------------ALS 80
            +L ++A E Q   E  LQ++E+E+AEL++                             L+
Sbjct: 1050 KLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLN 1109

Query: 81   DMQVCLFQEREHVLRLYSENDRLR--IRELE-DKKKIQNLLALVGTDAGEVTYFCKEPPH 137
            ++Q  L Q+  HV  L  +  +L+  + +LE D  K       +     E+    +E   
Sbjct: 1110 ELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKR 1169

Query: 138  KVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEA-L 196
            KV+ L   ++   E  QS  S+ +   K S    S E K+ SE     +     + EA L
Sbjct: 1170 KVSELTSKLKTTDEEFQSLKSSHEKSNK-SLEDKSLEFKKLSEELAIQLDICCKKTEALL 1228

Query: 197  QAQLGEQTKLSREQIEGLI------EDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELL 250
            +A+  E   +S  +   ++      + R   ++E  +      ++++   + L   Q  L
Sbjct: 1229 EAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTL 1288

Query: 251  YESTKDFLQLRSENQNKEKSW-------MLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVM 303
              S +       E +N+ KS        + EK+ L  +    +    +KE  I ++   +
Sbjct: 1289 NISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKEL 1348

Query: 304  HESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMR--REIFKDRTN 361
             E+ +A +   + LK+K V+   LS    +  + L+  ++   +E  +   R+ + +   
Sbjct: 1349 SENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKC 1408

Query: 362  KMGKRLQIMTKRYEALERRRIL---EVEGFKTDIKVLRQK-----------LKDLE-QML 406
            ++  ++Q ++ + + L + +I    +V+ +       ++K           +K+L+ Q+ 
Sbjct: 1409 ELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLE 1468

Query: 407  YKATVNARANQDLALLCEVRD-SNRRAHKIQGELKNLKSKVFGLENEL 453
             K+      ++ + LL E  D  N+R   ++GE+++ KSK+   E+ L
Sbjct: 1469 LKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNL 1516



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 91/486 (18%), Positives = 195/486 (40%), Gaps = 69/486 (14%)

Query: 14   EDRLAKLHPSKELLEYYQ----KKMAECEAENEDLLKKLELYK-EACEGQHKLECDLQQR 68
            E++LA+L      LE  +    K++AE EA+ +D+  +L+ +K +  +   +LE    + 
Sbjct: 818  EEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEM 877

Query: 69   EEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELE-DKKKIQNLLALVGTDAGE 127
            E+++  L +          +E+E   ++  E + + ++  E  KK+I+ L   +      
Sbjct: 878  EQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDS 937

Query: 128  VTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESS-EHYQRDI 186
            +    +E   K    +K ++ V +  +      K      + +  +E + ++ E  Q++ 
Sbjct: 938  IHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEK 997

Query: 187  QTLILQVEALQAQ-LGEQTKLSR------EQIEGLIEDRRIHLEEIQVQHQRNQNKIKEL 239
            Q     +E  QA   G    +SR      EQIE L E  R  L ++    ++  N+  E 
Sbjct: 998  QFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEE 1057

Query: 240  TKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKV 299
             + +H  Q                        + EK+  ++++KQ  +    +++++ K 
Sbjct: 1058 LQEIHEIQ------------------------LQEKEQEVAELKQKILLFGCEKEEMNKE 1093

Query: 300  LPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIR------------- 346
            +  + E    Q   +  L+++L Q+    N   +    L+  L ++              
Sbjct: 1094 ITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFL 1153

Query: 347  ----EEEGMRREIFKDRTNKMGKRLQIMTKRYEALE---RRRILEVEGFKTDIKVLRQKL 399
                 E  M  E  K + +++  +L+   + +++L+    +    +E    + K L ++L
Sbjct: 1154 QEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEEL 1213

Query: 400  --------KDLEQMLYKAT---VNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFG 448
                    K  E +L   T   +N  +++  A+L  +     R  K++  L      V  
Sbjct: 1214 AIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSE 1273

Query: 449  LENELR 454
            LE +LR
Sbjct: 1274 LEAQLR 1279



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 69/313 (22%), Positives = 135/313 (43%), Gaps = 45/313 (14%)

Query: 174  ERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQ 233
            E++   +  + DI++L+ + EALQ + G Q + + E+ E  I   +  L E       N 
Sbjct: 1301 EKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEK-ESCITQLKKELSE-------NI 1352

Query: 234  NKIKELTKNLHHTQELLYESTKDFLQLRSENQNK-------------EKSWMLEKDNLMS 280
            N +  + + L   +  +   +K    L  + QN               K +  EK  L+ 
Sbjct: 1353 NAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLD 1412

Query: 281  KIK--QYRVQCKKKEDKIGKVLPVMHESH-------HAQSEY------IKSLKDKLVQEK 325
            +++   ++V    KE KI  +  V   S+        AQS +      +K L+ +L  + 
Sbjct: 1413 QVQDLSFKVDTLSKE-KISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKS 1471

Query: 326  KLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEV 385
            K +    EQ   L+EEL +  +     +   +D  +KM K+   +    ++ +  RI+E+
Sbjct: 1472 KEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKS-QTARIMEL 1530

Query: 386  EGFKT----DIKVLRQKLKDLEQMLYKATVNARANQDLALLCEV-RDSNRRAHKIQGELK 440
            E   T    +I+ L + LK+  Q   K   +    Q L    E+  + + R  + + ++ 
Sbjct: 1531 EDHITQKTIEIESLNEVLKNYNQQ--KDIEHKELVQKLQHFQELGEEKDNRVKEAEEKIL 1588

Query: 441  NLKSKVFGLENEL 453
             L+++V+ ++ EL
Sbjct: 1589 TLENQVYSMKAEL 1601


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 105/504 (20%), Positives = 215/504 (42%), Gaps = 88/504 (17%)

Query: 14   EDRLAKLHPSKELLEYYQKKMAECEAENE-------DLLKKLELYKEACEGQHKLECDLQ 66
            E ++A+    +E L    + +AE E E E       +L K+ E+ K A E    L  DL+
Sbjct: 1410 ELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALE---LLSLDLK 1466

Query: 67   QREEEIAELQKALSDMQVC---------LFQEREHVLRLYSENDRLRIRELE-DKKKIQN 116
            +R +E+   Q+ + +++ C           QERE  L +  E    +IRELE D++  +N
Sbjct: 1467 KRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQRE----QIRELEKDRETQRN 1522

Query: 117  LLA-----------LVGTDAGEV--------TYFC-----KEPPHKVTILQKTIQAVGEC 152
            +L            ++ +  G+V        T  C     +E  HK+   QK I+ +   
Sbjct: 1523 VLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQ 1582

Query: 153  EQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIE 212
             +++  A        + R    + +SS+ +  +  + +L  E  +    ++ K  REQIE
Sbjct: 1583 RETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERD--QEVKSQREQIE 1640

Query: 213  GLIEDRR--------------IHLEEIQVQHQRNQNKIKELTKNLHHTQELLYE------ 252
             L   +               +  E IQV   +   + K L ++L   +  L E      
Sbjct: 1641 ELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELT 1700

Query: 253  STKDFLQLRSEN---QNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHA 309
            + +  +Q R+E     +K +   LE   L+ + K+  V+C+++       +  + E    
Sbjct: 1701 TQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEH------IHELQELKDQ 1754

Query: 310  QSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQI 369
              + ++ L  K+ +   L +  +++ + L+++L   RE+  ++ +  + + ++  + L  
Sbjct: 1755 LEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQ 1814

Query: 370  MTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSN 429
              +  EAL++ +  + +G +  +K   +K   L+  L +A +  +         E++D  
Sbjct: 1815 RDQELEALQQEQ-QQAQGQEERVK---EKADALQGALEQAHMTLKERHG-----ELQDHK 1865

Query: 430  RRAHKIQGELKNLKSKVFGLENEL 453
             +A +++ EL     +V  LE  L
Sbjct: 1866 EQARRLEEELAVEGRRVQALEEVL 1889



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 94/486 (19%), Positives = 212/486 (43%), Gaps = 54/486 (11%)

Query: 18   AKLHPSKELLEYYQKKMAECEAENEDLLKK---LELY-KEACEGQHKLECDLQQREEEIA 73
            +++  +++     Q  +AE E   E L +K   LE   ++A E   +L+ DL+  +EE  
Sbjct: 631  SRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKE 690

Query: 74   ELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAG-EVTYFC 132
            E+QK LS+ +    Q+     +L   +   + +E    + +Q   ALV   A  EV    
Sbjct: 691  EIQKKLSESR---HQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQA 747

Query: 133  KEPPHKVTILQKTIQAVGECEQS-ESSAFKADPKISKRRPSRERKE--------SSEHYQ 183
             E   +   L + +Q +   ++  ESS F+A  + S    ++ + E        + E  Q
Sbjct: 748  VERDRQD--LAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQ 805

Query: 184  RDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKEL--TK 241
             +++ L L+++  ++Q  ++   +  Q+    ++ +  LE+ +  H++  N+++E    +
Sbjct: 806  GEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKE 865

Query: 242  NLHHTQELL-----YESTKDFLQLRSENQNKEKSWML-----EKDNLMSKIKQYRVQCKK 291
               H QEL       E  K  L++R + Q  E   +      E+    S + Q +++ +K
Sbjct: 866  RSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEK 925

Query: 292  KEDKIGKVLPVMHESHHAQSEYIKSLKDKL----VQEKKLSNMYQEQCISLEEELARIRE 347
            +   + + L    +     S+ ++ L+  +    ++E++ + + Q Q    + EL     
Sbjct: 926  ERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAAR 985

Query: 348  EEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKL-------- 399
            +        ++ ++ + +    + K+ E L+ + + + +  +   + +++KL        
Sbjct: 986  QHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNR 1045

Query: 400  --KDLEQMLYKATVNARANQDLALLCEVRDSNRR---------AHKIQGELKNLKSKVFG 448
              K+LE+     T++    +   L+ +  DS R+           + QGE K L +++  
Sbjct: 1046 IQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMEL 1105

Query: 449  LENELR 454
            L  E++
Sbjct: 1106 LRQEVK 1111



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 87/447 (19%), Positives = 187/447 (41%), Gaps = 53/447 (11%)

Query: 1    MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKL-ELYKEACEGQH 59
            M +  E    PS   R +  H   +L+   ++K  EC+ E+   L++L +  ++  +G H
Sbjct: 1706 MQERAEEGKGPSKAQRGSLEH--MKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLH 1763

Query: 60   KLECD----LQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQ 115
            +   +    L QRE+EI  LQ+ L + +       +  L+  S   +L   +    ++ Q
Sbjct: 1764 RKVGETSLLLSQREQEIVVLQQQLQEAR------EQGELKEQSLQSQLDEAQRALAQRDQ 1817

Query: 116  NLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRER 175
             L AL            +    +  + +K     G  EQ+  +  +   ++      ++ 
Sbjct: 1818 ELEALQQEQQ-------QAQGQEERVKEKADALQGALEQAHMTLKERHGEL------QDH 1864

Query: 176  KESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNK 235
            KE +   + ++     +V+AL+  LG+    SREQ + L+  +    ++   Q Q ++ +
Sbjct: 1865 KEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQ----QQCAEQAQEHEVE 1920

Query: 236  IKELTKNLHHTQELLYESTKDFLQLRSENQ---NKEKSWMLEKDNLMSKIKQYRVQCKKK 292
             + L  +    Q +L E  ++   LR+E+Q   ++E++     + L   + +     + K
Sbjct: 1921 TRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGK 1980

Query: 293  EDKIGKVLPVMH----------------ESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCI 336
            E  + +   +                  ++H  Q E    +++  +Q++ L   YQE   
Sbjct: 1981 EQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDL--RYQEDVQ 2038

Query: 337  SLEEELARIREEEGMRREIFKDRTNKMGKRLQ--IMTKRYEALERRRILEVEGFKTDIKV 394
             L++ LA+  EE   ++E  +     + +R+Q  ++ ++    + R   E+ G    ++ 
Sbjct: 2039 QLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRE 2098

Query: 395  LRQKLKDLEQMLYKATVNARANQDLAL 421
            L+  L   EQ + +     + N   AL
Sbjct: 2099 LQLTLAQKEQEILELRETQQRNNLEAL 2125



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 107/523 (20%), Positives = 214/523 (40%), Gaps = 83/523 (15%)

Query: 14   EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQH-----------KLE 62
            E++  +LH +    E  Q+ +   EA+  + L +L   +EA E  H           ++ 
Sbjct: 508  EEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVT 567

Query: 63   CDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKI-----QNL 117
              L + E+ IAEL  + + ++  +   R   ++L + N+ L + ++   +++     +N 
Sbjct: 568  AALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQ 627

Query: 118  LALVGTDAGEVTY------FCKEPPHKVTILQKTIQAVGECEQSESSA--FKADPK-ISK 168
                  +A E           +    +  + +K      + +++E +    +AD + I +
Sbjct: 628  SVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQE 687

Query: 169  RRPSRERKESSEHYQRDIQTLIL---------QVEALQAQLGEQTKLSRE------QIEG 213
             +   ++K S   +Q++  T  L         Q E L   + E+  L RE      +++ 
Sbjct: 688  EKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQA 747

Query: 214  LIEDRRIHLEEIQ------------VQHQRNQNKIKELTKNLHHTQELLYESTKDFLQ-- 259
            +  DR+   E++Q            +   + QN + E+TK     Q       K+ +Q  
Sbjct: 748  VERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGE 807

Query: 260  ---LRSENQNKEKSWMLEKDNLMSKIKQYR-------VQCKKKEDKIGKVLPVMHESHHA 309
               L+ E   +      E+D    ++ Q          Q K   +K    L    E   +
Sbjct: 808  VRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERS 867

Query: 310  --QSEYIKSL----KDKLVQEKKLSNMYQE-QCISLEEELARIREEEG---MRREIFKDR 359
              Q E  K+L    ++K+  E +L     E + I  + E  R + E     M+ E  K+R
Sbjct: 868  WHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKER 927

Query: 360  TNKMGKRLQIMTKRYEA---LER-RRILEVEGFKTD--IKVLRQKLKDLEQMLYKATVNA 413
             + +   LQ   +  +A   LER R+ ++V+  K      +L+ +L++ ++ L +A    
Sbjct: 928  VSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQH 987

Query: 414  RANQDLALLCEVRDS-NRRAHKIQGELKNLKSKVFGLENELRL 455
            R   DLA L E   S  +    +Q ++++LKS++   ++  RL
Sbjct: 988  R--DDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRL 1028



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 71/328 (21%), Positives = 135/328 (41%), Gaps = 32/328 (9%)

Query: 29   YYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQ 88
            ++Q+++A+     E   +K+EL     E Q ++E    QREEE  + + AL  MQ+    
Sbjct: 868  WHQQELAKALESLER--EKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQL---- 921

Query: 89   EREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQA 148
                      E ++ R+  LE   + Q  LA    DA +     ++      + ++    
Sbjct: 922  ----------ETEKERVSLLETLLQTQKELA----DASQQLERLRQDMKVQKLKEQETTG 967

Query: 149  VGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSR 208
            + + +  E+     +     R      +E S    +D   L  QVE L++QL  Q    R
Sbjct: 968  ILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQR 1027

Query: 209  EQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFL---QLRSENQ 265
               + + E  R   E  ++Q +  + K       +   Q LL     D +   +L +  Q
Sbjct: 1028 LVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQ 1087

Query: 266  NKEKSWMLEKDNLMSKIKQYRVQCKKKEDKI----GKVLPVMHESHHAQSEYIKSLKDKL 321
            + +++   E+  L ++++  R + K+KE        ++L  +  SH  + +   SL    
Sbjct: 1088 DMQEA-QGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASL---W 1143

Query: 322  VQEKKLSNMYQEQCISLEEELARIREEE 349
             QE K + + Q +  S E +L  +  E+
Sbjct: 1144 AQEAKAAQL-QLRLRSTESQLEALAAEQ 1170



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 101/515 (19%), Positives = 209/515 (40%), Gaps = 93/515 (18%)

Query: 10   LPSPEDRLAKLHPSKEL----LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDL 65
            L   E RL  L  +  +    L   ++ M E + E ++L  ++EL ++  + +   E D 
Sbjct: 1061 LMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEK---EADF 1117

Query: 66   QQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDA 125
              +E   A+L + L    +   Q R  +    ++  +L++R    + +++ L A      
Sbjct: 1118 LAQE---AQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAA--EQQP 1172

Query: 126  GEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRD 185
            G       +     + LQ+ + +V E     S    + P +    P +    S   ++R 
Sbjct: 1173 GNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSL--FKRG 1230

Query: 186  IQTLILQVEALQAQLG---------EQTK-LSREQIEGL--------IEDRRIH--LEEI 225
                 L  EA+ + L          +QT+ + R+Q++ L         E  ++H  L+++
Sbjct: 1231 PLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDL 1290

Query: 226  QVQHQRNQ----------NKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEK 275
            Q Q  +NQ          N ++     LH T   L    +     R E Q + +     K
Sbjct: 1291 QRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAK 1350

Query: 276  DNLMSKIKQYR---VQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQ 332
            +NL ++++  +   V+ + +    G    ++ E        +K   +++  E++ +   Q
Sbjct: 1351 ENLTAQVEHLQAAVVEARAQASAAG----ILEEDLRTARSALKLKNEEVESERERAQALQ 1406

Query: 333  E-------QCISLEEELARI------REEE-----GMRREIFKDR-------------TN 361
            E       Q  +L+E LA +      REEE     G  +E+ K R               
Sbjct: 1407 EQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLK 1466

Query: 362  KMGKRLQIMTKRYEALER-RRILE-----VEGFKTDIKVLRQKLKDLEQMLYKATVNARA 415
            K  + + +  ++ + LE+ R +LE     V+  +  + V R+++++LE+   +   N   
Sbjct: 1467 KRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKD-RETQRNVLE 1525

Query: 416  NQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLE 450
            +Q    L E+   ++     +G++++LK ++  LE
Sbjct: 1526 HQ----LLELEKKDQMIESQRGQVQDLKKQLVTLE 1556



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 87/464 (18%), Positives = 173/464 (37%), Gaps = 75/464 (16%)

Query: 38  EAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLY 97
           E   ++LL +LE  ++ CE   ++   L+   E+   + KAL          RE V +L 
Sbjct: 93  EPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKAL----------REDVEKLT 142

Query: 98  SE----NDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPP----HKVTILQKT---- 145
            +     D L  +E + + + +     +  + G +    +E      H + +   T    
Sbjct: 143 VDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDL 202

Query: 146 IQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTK 205
           ++   E  +   S      +++    SRE   S     R+   L+L +   Q    E  +
Sbjct: 203 MELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHE 262

Query: 206 LSREQIE---------GLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKD 256
            S+E I+           ++DR   L  +  Q Q+     +++ K L  T E+L  +  +
Sbjct: 263 RSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTE 322

Query: 257 FLQLRSENQNKEKSWMLEKDNLMSKIKQYRV-------QCKKKEDKI------------- 296
            ++  +      +   L    ++  I Q  V       Q    E+ +             
Sbjct: 323 LMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQ 382

Query: 297 --GKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGM--- 351
              K L ++      + + ++ L+ +L   ++  N+ Q+Q    EEE   +R+       
Sbjct: 383 DADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTG 442

Query: 352 RREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATV 411
            R+    +T  +   +  ++K  E L++ R           + LRQ+L+ LEQ  ++   
Sbjct: 443 ERDTLAGQTVDLQGEVDSLSKERELLQKAR-----------EELRQQLEVLEQEAWRL-- 489

Query: 412 NARANQDLAL-----LCEVRDSNRRAHKIQGELKNLKSKVFGLE 450
             R N +L L       +  +     H    E + L+  + GLE
Sbjct: 490 -RRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLE 532


>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 436

 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 65/346 (18%), Positives = 161/346 (46%), Gaps = 26/346 (7%)

Query: 40  ENEDLLKKLELYKEACEGQ-HKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYS 98
           E E  +++ E      EGQ  + E  ++++E ++ E +  + + +    Q RE   ++  
Sbjct: 112 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG---QVREQEGQVRE 168

Query: 99  ENDRLRIRE---LEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQS 155
           +  ++R +E    E + +++     +G   G++    ++   +   +QK  + +GE E+ 
Sbjct: 169 QEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQ 228

Query: 156 ESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLI 215
                       +     E++E  +  +  +Q    Q+   + Q+ EQ +  REQ E ++
Sbjct: 229 MRK---------QEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQML 279

Query: 216 EDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEK 275
           + +    +E Q   Q  Q  ++E  + +   +E + E  +   + + E   K++  M E+
Sbjct: 280 KQKEQTEQEEQTGEQEEQ--MREQEEQMREQEEQMREQEEQMRE-QEEQMGKQEEQMWEQ 336

Query: 276 DNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQC 335
              M + K+   Q  K+E+++G+      E    Q E ++  ++++ ++++     +EQ 
Sbjct: 337 KEQMWEQKE---QMWKQEEQMGE----QEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQM 389

Query: 336 ISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRR 381
              EE++   +E+ G ++E  +++  +MG++ + M K+ E +  ++
Sbjct: 390 RKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQK 435



 Score = 37.4 bits (85), Expect = 0.028
 Identities = 40/213 (18%), Positives = 99/213 (46%), Gaps = 11/213 (5%)

Query: 169 RRPSRERKESSEHYQRDIQTLILQVEALQAQLGE-QTKLSREQIEGLIEDRRIHLEEIQV 227
           R  + E KE +   Q ++Q +  +   +Q  + E + KL  ++I  L ++ ++  +E QV
Sbjct: 3   RITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIP-LPQEGQVREQEGQV 61

Query: 228 QHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRV 287
           + Q  Q  ++E    +   +  + E      +   E Q +E+   + +     ++++   
Sbjct: 62  REQEGQ--VREQEGQVREQEGQVREQEGQVRE--QEGQVREQEGQVREQE--GQVREQEG 115

Query: 288 QCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIRE 347
           Q +++E ++ +    + E      E    ++++  Q ++     +EQ   + E+  ++RE
Sbjct: 116 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 175

Query: 348 EEGMRRE---IFKDRTNKMGKRLQIMTKRYEAL 377
           +EG  RE     +++  +MG++   M ++ E +
Sbjct: 176 QEGQVREQEGQVREQEGQMGEQEGQMGEQEEQM 208


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 101/479 (21%), Positives = 206/479 (43%), Gaps = 67/479 (13%)

Query: 14   EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA 73
            + ++  L  + E +E  +++ +E E EN  L K L+ +K        LE +  Q +EE  
Sbjct: 645  QKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENL 704

Query: 74   ELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLA-LVGTDAGEVTYFC 132
            EL++ +  ++    +    + +L  EN  L   + + KK ++ L A    T+  EV+Y  
Sbjct: 705  ELRRNVESLKCASMK----MAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQG 760

Query: 133  KEPPHKVTILQKTI--------QAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQR 184
             +  ++   LQKT+        Q   E +  E         + + + S +R E  E   +
Sbjct: 761  LDIENQ--RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENK 818

Query: 185  DIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLH 244
             ++    Q+E  + QL ++ K  R+Q E  I+D  +    +++ +   +N  K L+K + 
Sbjct: 819  SLEQETSQLEKDKKQLEKENKRLRQQAE--IKDTTLEENNVKIGNLEKEN--KTLSKEI- 873

Query: 245  HTQELLYESTKDFLQLRSENQNKEKSWMLE-------KDNLMS---KIKQYRVQCKKKED 294
                +  ES     +L  EN+   K   ++       +++L+S   K +Q     +K   
Sbjct: 874  ---GIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH 930

Query: 295  KIGKV----LPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEG 350
            ++ K+      ++H+         K L+ KL    K S   +E+ I+  E  AR+ E   
Sbjct: 931  ELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALE--ARLEESTN 988

Query: 351  MRREIFKDRTNKMGKRLQIMTKRYEALERRR-----------------ILEVEGFKTDIK 393
              +++ ++        L+ + K YEAL++R+                   E E  +T  +
Sbjct: 989  YNQQLRQE--------LKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRE 1040

Query: 394  VLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 452
            +L+ K + +E     AT+ A   +  AL  +++    + + +Q ++  L+ +   L+ +
Sbjct: 1041 LLKVKDRLIEVERNNATLQA---EKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ 1096



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 112/489 (22%), Positives = 204/489 (41%), Gaps = 89/489 (18%)

Query: 27  LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCL 86
           +E+Y+ ++ E + +N+ LL+   + ++  EG       L + E+E  +L+  L DM++  
Sbjct: 339 IEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMER 398

Query: 87  FQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEV--TYFCKEPP-----HKV 139
             +R+ +  L  EN  L   E+  K+ +   L L G +  ++  T    E P     H+V
Sbjct: 399 DMDRKKIEELMEENMTL---EMAQKQSMDESLHL-GWELEQISRTSELSEAPQKSLGHEV 454

Query: 140 TIL------------QKTIQAVGECEQSESSAFKADPKISKRRPSRER------------ 175
             L            Q   + V E   +  S      KI K     +R            
Sbjct: 455 NELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEI 514

Query: 176 ---KESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEE-IQVQHQR 231
              K+S ++ Q   + L+ +   L+  +    + S  QI+ ++E    HL + +    QR
Sbjct: 515 VQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIK-ILEQENEHLNQTVSSLRQR 573

Query: 232 NQNKIKELTKNLHHTQELLYESTKDF-----------LQLRSENQN-KEKS--------- 270
           +Q   +   K++    ++L+ES K+             Q++ E ++ KEK          
Sbjct: 574 SQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENE 633

Query: 271 -WMLEKDN--LMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKL 327
              LEK+N  L  KI   ++ C+K E         + + +       + LK  L   K L
Sbjct: 634 LHHLEKENELLQKKITNLKITCEKIE--------ALEQENSELERENRKLKKTLDSFKNL 685

Query: 328 SNMYQEQCISLEEELARIREEE-GMRR--EIFKDRTNKMGKRLQIMTKRYEALERRRILE 384
           +     Q  SLE+E +++ EE   +RR  E  K  + KM  +LQ+  K  E+       E
Sbjct: 686 T----FQLESLEKENSQLDEENLELRRNVESLKCASMKMA-QLQLENKELES-------E 733

Query: 385 VEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKS 444
            E  K  +++L+   K  E++          NQ L    E  +SN++  +++ EL++L+ 
Sbjct: 734 KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLE--NSNKKIQQLESELQDLEM 791

Query: 445 KVFGLENEL 453
           +   L+  L
Sbjct: 792 ENQTLQKNL 800



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 97/449 (21%), Positives = 197/449 (43%), Gaps = 57/449 (12%)

Query: 25   ELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQV 84
            E ++    K+++ E E   + K+LE YKE  E   +LE +L   E+E   LQK ++++++
Sbjct: 594  ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKI 653

Query: 85   CLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQK 144
                  E +  L  EN  L     + KK + +                K    ++  L+K
Sbjct: 654  TC----EKIEALEQENSELERENRKLKKTLDSF---------------KNLTFQLESLEK 694

Query: 145  TIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQT 204
                + E E  E        K +  + ++ + E+ E  + + + L   +E L+A   ++T
Sbjct: 695  ENSQLDE-ENLELRRNVESLKCASMKMAQLQLENKE-LESEKEQLKKGLELLKASF-KKT 751

Query: 205  KLSREQIEGL-IEDRRIH--LEEIQVQHQRNQNKIKEL---TKNLHHTQELLYESTKDFL 258
            +      +GL IE++R+   LE    + Q+ ++++++L    + L    E L  S+K   
Sbjct: 752  ERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE 811

Query: 259  QLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLK 318
            QL  EN++ E+          S++++ + Q +K+  ++ +   +   +    +  I +L+
Sbjct: 812  QLEKENKSLEQE--------TSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE 863

Query: 319  DKLVQEKKLSNMYQEQCISLEE------ELAR-----IREEEGMRREIFKD--RTNKMGK 365
             +     K   +Y+E C+ L+E      EL +     I+    +R ++  +  +T +M  
Sbjct: 864  KENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNN 923

Query: 366  RLQIMTKRYE--ALERRRILEVEGFKTD--IKVLRQKLKDLEQMLYKATVNARANQDLAL 421
             L+ +T   E   L + R+L  E    D   K+L  KL    +   K ++  +  +  AL
Sbjct: 924  DLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKL----ESTLKKSLEIKEEKIAAL 979

Query: 422  LCEVRDSNRRAHKIQGELKNLKSKVFGLE 450
               + +S     +++ ELK +K     L+
Sbjct: 980  EARLEESTNYNQQLRQELKTVKKNYEALK 1008



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 88/434 (20%), Positives = 177/434 (40%), Gaps = 62/434 (14%)

Query: 25  ELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQV 84
           E+ E    ++ + E EN+ L K +E  +   +        + + E+E   L K +  ++ 
Sbjct: 453 EVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN 512

Query: 85  CLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQK 144
            + QE++ +                  +  QNL               K+   +   L+K
Sbjct: 513 EIVQEKQSL------------------QNCQNL--------------SKDLMKEKAQLEK 540

Query: 145 TIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQT 204
           TI+ + E  + +    + + +   +  S  R+ S    Q   +  +  +E     L E  
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRS----QISAEARVKDIEKENKILHESI 596

Query: 205 KLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSEN 264
           K +  ++  +  ++R   +E++  ++    + +EL   LHH      E   + LQ +  N
Sbjct: 597 KETSSKLSKIEFEKRQIKKELE-HYKEKGERAEELENELHH-----LEKENELLQKKITN 650

Query: 265 Q--NKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKL- 321
                EK   LE++N  S++++   + KK  D   K L    ES   ++  +     +L 
Sbjct: 651 LKITCEKIEALEQEN--SELERENRKLKKTLDSF-KNLTFQLESLEKENSQLDEENLELR 707

Query: 322 --VQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALER 379
             V+  K ++M   Q     +EL   +E+     E+ K  + K  +RL++  +  +   +
Sbjct: 708 RNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLK-ASFKKTERLEVSYQGLDIENQ 766

Query: 380 RRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLAL-LCEVRDSNRRAHKIQGE 438
           R    +E     I+ L  +L+DLE            NQ L   L E++ S++R  +++ E
Sbjct: 767 RLQKTLENSNKKIQQLESELQDLEM----------ENQTLQKNLEELKISSKRLEQLEKE 816

Query: 439 LKNLKSKVFGLENE 452
            K+L+ +   LE +
Sbjct: 817 NKSLEQETSQLEKD 830



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 74/337 (21%), Positives = 127/337 (37%), Gaps = 65/337 (19%)

Query: 6    ESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDL 65
            E   L S  D L K H   ELL   Q       +E E L+ K    K A +       DL
Sbjct: 1145 EREDLKSLYDSLIKDHEKLELLHERQA------SEYESLISKHGTLKSAHKNLEVEHRDL 1198

Query: 66   QQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDA 125
            + R  ++ + +  L D++  L  E+E +L             LE+K           T A
Sbjct: 1199 EDRYNQLLKQKGQLEDLEKMLKVEQEKML-------------LENKNH--------ETVA 1237

Query: 126  GEVTYFCKEPP---HKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHY 182
             E    C E     H  + L K  + + + +     +   + K+ + R   E  +  E Y
Sbjct: 1238 AEYKKLCGENDRLNHTYSQLLKETEVL-QTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQY 1296

Query: 183  QRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKN 242
            Q        Q++    +L  Q +L   Q++G +E+   HL + Q+Q    QN+       
Sbjct: 1297 Q--------QLDITSTKLNNQCEL-LSQLKGNLEEENRHLLD-QIQTLMLQNR------- 1339

Query: 243  LHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPV 302
                             L  +N   +  + +E+   + K+ + R Q +K E+KI      
Sbjct: 1340 ----------------TLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKF 1383

Query: 303  MHES-HHAQSEYIKSLKDKLVQEKKLSNMYQEQCISL 338
               S    +  +I     KL++ KK  N  +++ ++L
Sbjct: 1384 YDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTL 1420


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 97/448 (21%), Positives = 197/448 (43%), Gaps = 56/448 (12%)

Query: 25   ELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQV 84
            E ++    K+++ E E   + K+LE YKE  E   +LE +L   E+E   LQK ++++++
Sbjct: 594  ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKI 653

Query: 85   CLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQK 144
                  E +  L  EN  L     + KK + +                K    ++  L+K
Sbjct: 654  TC----EKIEALEQENSELERENRKLKKTLDSF---------------KNLTFQLESLEK 694

Query: 145  TIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQT 204
                + E E  E        K +  + ++ + E+ E  + + + L   +E L+A   ++T
Sbjct: 695  ENSQLDE-ENLELRRNVESLKCASMKMAQLQLENKE-LESEKEQLKKGLELLKASF-KKT 751

Query: 205  KLSREQIEGL-IEDRRIH--LEEIQVQHQRNQNKIKEL---TKNLHHTQELLYESTKDFL 258
            +      +GL IE++R+   LE    + Q+ ++++++L    + L    E L  S+K   
Sbjct: 752  ERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE 811

Query: 259  QLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLK 318
            QL  EN++ E+          S++++ + Q +K+  ++ +   +   +    +  I +L+
Sbjct: 812  QLEKENKSLEQE--------TSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE 863

Query: 319  DKLVQEKKLSNMYQEQCISLEE------ELAR-----IREEEGMRREIFKD--RTNKMGK 365
             +     K   +Y+E C+ L+E      EL +     I+    +R ++  +  +T +M  
Sbjct: 864  KENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNN 923

Query: 366  RLQIMTKRYE--ALERRRILEVEGFKTD-IKVLRQKLKDLEQMLYKATVNARANQDLALL 422
             L+ +T   E   L + R+L  E    D  K+L  KL    +   K ++  +  +  AL 
Sbjct: 924  DLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKL----ESTLKKSLEIKEEKIAALE 979

Query: 423  CEVRDSNRRAHKIQGELKNLKSKVFGLE 450
              + +S     +++ ELK +K     L+
Sbjct: 980  ARLEESTNYNQQLRQELKTVKKNYEALK 1007



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 112/489 (22%), Positives = 204/489 (41%), Gaps = 89/489 (18%)

Query: 27  LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCL 86
           +E+Y+ ++ E + +N+ LL+   + ++  EG       L + E+E  +L+  L DM++  
Sbjct: 339 IEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMER 398

Query: 87  FQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEV--TYFCKEPP-----HKV 139
             +R+ +  L  EN  L   E+  K+ +   L L G +  ++  T    E P     H+V
Sbjct: 399 DMDRKKIEELMEENMTL---EMAQKQSMDESLHL-GWELEQISRTSELSEAPQKSLGHEV 454

Query: 140 TIL------------QKTIQAVGECEQSESSAFKADPKISKRRPSRER------------ 175
             L            Q   + V E   +  S      KI K     +R            
Sbjct: 455 NELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEI 514

Query: 176 ---KESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEE-IQVQHQR 231
              K+S ++ Q   + L+ +   L+  +    + S  QI+ ++E    HL + +    QR
Sbjct: 515 VQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIK-ILEQENEHLNQTVSSLRQR 573

Query: 232 NQNKIKELTKNLHHTQELLYESTKDF-----------LQLRSENQN-KEKS--------- 270
           +Q   +   K++    ++L+ES K+             Q++ E ++ KEK          
Sbjct: 574 SQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENE 633

Query: 271 -WMLEKDN--LMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKL 327
              LEK+N  L  KI   ++ C+K E         + + +       + LK  L   K L
Sbjct: 634 LHHLEKENELLQKKITNLKITCEKIE--------ALEQENSELERENRKLKKTLDSFKNL 685

Query: 328 SNMYQEQCISLEEELARIREEE-GMRR--EIFKDRTNKMGKRLQIMTKRYEALERRRILE 384
           +     Q  SLE+E +++ EE   +RR  E  K  + KM  +LQ+  K  E+       E
Sbjct: 686 T----FQLESLEKENSQLDEENLELRRNVESLKCASMKMA-QLQLENKELES-------E 733

Query: 385 VEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKS 444
            E  K  +++L+   K  E++          NQ L    E  +SN++  +++ EL++L+ 
Sbjct: 734 KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLE--NSNKKIQQLESELQDLEM 791

Query: 445 KVFGLENEL 453
           +   L+  L
Sbjct: 792 ENQTLQKNL 800



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 102/479 (21%), Positives = 207/479 (43%), Gaps = 68/479 (14%)

Query: 14   EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA 73
            + ++  L  + E +E  +++ +E E EN  L K L+ +K        LE +  Q +EE  
Sbjct: 645  QKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENL 704

Query: 74   ELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLA-LVGTDAGEVTYFC 132
            EL++ +  ++    +    + +L  EN  L   + + KK ++ L A    T+  EV+Y  
Sbjct: 705  ELRRNVESLKCASMK----MAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQG 760

Query: 133  KEPPHKVTILQKTI--------QAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQR 184
             +  ++   LQKT+        Q   E +  E         + + + S +R E  E   +
Sbjct: 761  LDIENQ--RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENK 818

Query: 185  DIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLH 244
             ++    Q+E  + QL ++ K  R+Q E  I+D  +    +++ +   +N  K L+K + 
Sbjct: 819  SLEQETSQLEKDKKQLEKENKRLRQQAE--IKDTTLEENNVKIGNLEKEN--KTLSKEI- 873

Query: 245  HTQELLYESTKDFLQLRSENQNKEKSWMLE-------KDNLMS---KIKQYRVQCKKKED 294
                +  ES     +L  EN+   K   ++       +++L+S   K +Q     +K   
Sbjct: 874  ---GIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH 930

Query: 295  KIGKV----LPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEG 350
            ++ K+      ++H+       Y K L+ KL    K S   +E+ I+  E  AR+ E   
Sbjct: 931  ELEKIGLNKERLLHDEQSTDDRY-KLLESKLESTLKKSLEIKEEKIAALE--ARLEESTN 987

Query: 351  MRREIFKDRTNKMGKRLQIMTKRYEALERRR-----------------ILEVEGFKTDIK 393
              +++ ++        L+ + K YEAL++R+                   E E  +T  +
Sbjct: 988  YNQQLRQE--------LKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRE 1039

Query: 394  VLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 452
            +L+ K + +E     AT+ A   +  AL  +++    + + +Q ++  L+ +   L+ +
Sbjct: 1040 LLKVKDRLIEVERNNATLQA---EKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ 1095



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 88/434 (20%), Positives = 177/434 (40%), Gaps = 62/434 (14%)

Query: 25  ELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQV 84
           E+ E    ++ + E EN+ L K +E  +   +        + + E+E   L K +  ++ 
Sbjct: 453 EVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN 512

Query: 85  CLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQK 144
            + QE++ +                  +  QNL               K+   +   L+K
Sbjct: 513 EIVQEKQSL------------------QNCQNL--------------SKDLMKEKAQLEK 540

Query: 145 TIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQT 204
           TI+ + E  + +    + + +   +  S  R+ S    Q   +  +  +E     L E  
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRS----QISAEARVKDIEKENKILHESI 596

Query: 205 KLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSEN 264
           K +  ++  +  ++R   +E++  ++    + +EL   LHH      E   + LQ +  N
Sbjct: 597 KETSSKLSKIEFEKRQIKKELE-HYKEKGERAEELENELHH-----LEKENELLQKKITN 650

Query: 265 Q--NKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKL- 321
                EK   LE++N  S++++   + KK  D   K L    ES   ++  +     +L 
Sbjct: 651 LKITCEKIEALEQEN--SELERENRKLKKTLDSF-KNLTFQLESLEKENSQLDEENLELR 707

Query: 322 --VQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALER 379
             V+  K ++M   Q     +EL   +E+     E+ K  + K  +RL++  +  +   +
Sbjct: 708 RNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLK-ASFKKTERLEVSYQGLDIENQ 766

Query: 380 RRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLAL-LCEVRDSNRRAHKIQGE 438
           R    +E     I+ L  +L+DLE            NQ L   L E++ S++R  +++ E
Sbjct: 767 RLQKTLENSNKKIQQLESELQDLEM----------ENQTLQKNLEELKISSKRLEQLEKE 816

Query: 439 LKNLKSKVFGLENE 452
            K+L+ +   LE +
Sbjct: 817 NKSLEQETSQLEKD 830



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 74/337 (21%), Positives = 127/337 (37%), Gaps = 65/337 (19%)

Query: 6    ESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDL 65
            E   L S  D L K H   ELL   Q       +E E L+ K    K A +       DL
Sbjct: 1144 EREDLKSLYDSLIKDHEKLELLHERQA------SEYESLISKHGTLKSAHKNLEVEHRDL 1197

Query: 66   QQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDA 125
            + R  ++ + +  L D++  L  E+E +L             LE+K           T A
Sbjct: 1198 EDRYNQLLKQKGQLEDLEKMLKVEQEKML-------------LENKNH--------ETVA 1236

Query: 126  GEVTYFCKEPP---HKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHY 182
             E    C E     H  + L K  + + + +     +   + K+ + R   E  +  E Y
Sbjct: 1237 AEYKKLCGENDRLNHTYSQLLKETEVL-QTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQY 1295

Query: 183  QRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKN 242
            Q        Q++    +L  Q +L   Q++G +E+   HL + Q+Q    QN+       
Sbjct: 1296 Q--------QLDITSTKLNNQCEL-LSQLKGNLEEENRHLLD-QIQTLMLQNR------- 1338

Query: 243  LHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPV 302
                             L  +N   +  + +E+   + K+ + R Q +K E+KI      
Sbjct: 1339 ----------------TLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKF 1382

Query: 303  MHES-HHAQSEYIKSLKDKLVQEKKLSNMYQEQCISL 338
               S    +  +I     KL++ KK  N  +++ ++L
Sbjct: 1383 YDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTL 1419


>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
          Length = 3907

 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 100/482 (20%), Positives = 208/482 (43%), Gaps = 67/482 (13%)

Query: 23   SKEL---LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDL---QQRE-----EE 71
            S+EL   LE  + K+   E  +++ L+ L+   E+ + Q  L+ +L   QQ++     ++
Sbjct: 3217 SRELQWALEKEKAKLGRSEERDKEELEDLKFSLES-QKQRNLQLNLLLEQQKQLLNESQQ 3275

Query: 72   IAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELE---DKKKIQNLLALVGTDAGEV 128
              E Q+ L D Q+   Q R   L++  E++++RIRE+    D+++  +         G+ 
Sbjct: 3276 KIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQ- 3334

Query: 129  TYFCKEPPHKVTILQKTIQAVGECEQS-------ESSAFKADPKISKRRPSRERKESSEH 181
                  PP     L K +Q   E + S       E+  +K D   ++++  ++R+   + 
Sbjct: 3335 ----SRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKT 3390

Query: 182  YQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTK 241
             Q + +      E  +     Q+K+  E ++  +E++R  + ++ ++ QR Q  ++E  K
Sbjct: 3391 LQTEQEA---NTEGQKKMHELQSKV--EDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQK 3445

Query: 242  NLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLP 301
                 QEL  E  ++  ++  +N N+  +W L  D   + + Q +++ + KE    K++ 
Sbjct: 3446 -----QELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIE 3500

Query: 302  VMHESHHAQSEYIKSLKDKL-VQEKKLSNMYQEQCISLEEELARIREEEGMRREI----- 355
             M+      +  ++ ++ KL     KL  + Q+    L+ E A   +   ++  I     
Sbjct: 3501 -MNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIIL 3559

Query: 356  -FKDRTNKMGKRLQIMTKRYE--ALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKA--- 409
              +  T + G+   +++      +L  R + +       I  L ++  DL  M+ K    
Sbjct: 3560 QLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQ 3619

Query: 410  -----------------TVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 452
                             ++N  AN +  +  E    NR    +Q  LK  +++V+ L+ E
Sbjct: 3620 IRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAE 3679

Query: 453  LR 454
            LR
Sbjct: 3680 LR 3681



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 102/520 (19%), Positives = 216/520 (41%), Gaps = 109/520 (20%)

Query: 27  LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD-------LQQREEEIAELQKAL 79
           +E  QK+  +      D+++++E   +    Q + E D       +Q ++E I +    +
Sbjct: 401 VEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQM 460

Query: 80  SDMQVCLFQEREHVLRLYSE----NDRLRIR---------ELED----KKKIQNLLALVG 122
            +M+     E E+ LR YS      D++++          +L+D    K+K++  L L+ 
Sbjct: 461 EEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLIL 520

Query: 123 TDAGEVTYFCKEPPHKVTI----LQKTIQAVGECEQSESSAFKA-----DPKISKRRPSR 173
            +   +    ++   +++     +Q+  Q + E E   + A K+     D K      S 
Sbjct: 521 EEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASE 580

Query: 174 ERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHL----------- 222
            RKE    ++ ++    +++E L+ +         E  E  +E  R  L           
Sbjct: 581 SRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKL 640

Query: 223 -EEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSK 281
            E+++++H+ N  K+K+    +H+ Q++      D LQ  +E   K ++   EKDNL++K
Sbjct: 641 KEDLEIEHRINIEKLKD-NLGIHYKQQI------DGLQ--NEMSQKIETMQFEKDNLITK 691

Query: 282 IKQYRVQCKKKED------------------KIGKVLPVMHESHHAQSEYIKSLKDKLVQ 323
             Q  ++  K +D                  ++ K + ++ +    +    + +++  ++
Sbjct: 692 QNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLK 751

Query: 324 EKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRIL 383
            + L    +E+   L+E+ A++  E      I KD    +   L+I T      +  R++
Sbjct: 752 TELLEKQMKEKENDLQEKFAQLEAE----NSILKDEKKTLEDMLKIHT---PVSQEERLI 804

Query: 384 EVEGFKT---------DIKVLRQKLKDLEQMLYK--------------ATVNARAN---- 416
            ++  K+         +I++L ++ +DL+Q   +              A  N   N    
Sbjct: 805 FLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQEL 864

Query: 417 -QDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRL 455
            ++ A L +V+D +    K + EL+  KSK+  L  EL L
Sbjct: 865 QEEYACLLKVKD-DLEDSKNKQELE-YKSKLKALNEELHL 902



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 81/458 (17%), Positives = 193/458 (42%), Gaps = 38/458 (8%)

Query: 14   EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACE----GQHKLECDLQQRE 69
            +  + KL    +++  +Q        E E L   L+   + C      + +L+ D+Q+R 
Sbjct: 2084 QQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERN 2143

Query: 70   EEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVT 129
            EEI +L+  + +++  L    +   ++    DR     +E K ++ +L   +  +   + 
Sbjct: 2144 EEIEKLEFRVRELEQALLVSADTFQKV---EDRKHFGAVEAKPEL-SLEVQLQAERDAID 2199

Query: 130  YFCKEPPHKVTILQKTIQAVG---ECEQSESSAFKADPKISKRRPS---RERKESSEHYQ 183
               KE    +T L++ ++      E +  E        +I K+  +   +E ++ ++ ++
Sbjct: 2200 RKEKE----ITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFK 2255

Query: 184  RDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKN- 242
             D++ L L ++   A   +   +   +   +I+++ + ++++  Q  + Q ++K  T N 
Sbjct: 2256 DDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNK 2315

Query: 243  -LHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLP 301
             +    EL+ +       L S+ +         K N   +I+Q     +K + ++  +  
Sbjct: 2316 VIEEKNELIRDLETQIECLMSDQE-------CVKRNREEEIEQLNEVIEKLQQELANIGQ 2368

Query: 302  VMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKD--- 358
                + H+ SE   SLK +L       ++   + ++LE+++    EE    + + K+   
Sbjct: 2369 KTSMNAHSLSEEADSLKHQL-------DVVIAEKLALEQQVETANEEMTFMKNVLKETNF 2421

Query: 359  RTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQD 418
            + N++ + L  + +  E++E+ + +        I  L +   +LE +L +  + +  NQ 
Sbjct: 2422 KMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQT 2481

Query: 419  LALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456
                 E  +       ++  L  L+S V   + EL  C
Sbjct: 2482 YFKSFE-ENGKGSIINLETRLLQLESTVSAKDLELTQC 2518



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 100/510 (19%), Positives = 203/510 (39%), Gaps = 99/510 (19%)

Query: 19  KLHPSKELLEYYQKKMAECEAENEDLLKKLELYK----EACEGQHKLECDLQQREEEIAE 74
           +L     LLE YQKK  +   +   L +K+++Y+    +  E  +K E  +Q++E  I E
Sbjct: 276 QLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEE--IQEKETIIEE 333

Query: 75  L---------------------QKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKK 113
           L                      K L ++Q  + Q+ + +  +  E    + +E +  ++
Sbjct: 334 LNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEE 393

Query: 114 IQNLLALVGT-----------DAGEVTYFCKEPPHKVTILQKTI-----QAVGECEQSES 157
           I+ L+  V             +   V    +E   K+  L+  +     Q + + +Q   
Sbjct: 394 IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELI 453

Query: 158 SAFKADPKISKRRPSRERKESSEHYQR--------------------DIQTLILQVEALQ 197
               A  +  K R   E + +   Y                       +Q    Q E L+
Sbjct: 454 RQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLK 513

Query: 198 AQLG---EQTKLSREQIEGLIEDRRIHLEEIQVQHQ---RNQNKIKELTKNLHHTQELLY 251
            +LG   E+    + Q+E L+E+     E+IQ   Q     ++K+ E  K+L   ++L  
Sbjct: 514 EELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKA 573

Query: 252 ESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQS 311
           E      + R E + K +          +++  Y+++ +  E +   VL  M ES  A+ 
Sbjct: 574 EIV-SASESRKELELKHE----------AEVTNYKIKLEMLEKEKNAVLDRMAESQEAEL 622

Query: 312 EYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMR-REIFKDRTNKMGKRLQIM 370
           E +++ +     E++LS + ++  I     + ++++  G+  ++      N+M ++++ M
Sbjct: 623 ERLRT-QLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETM 681

Query: 371 TKRYEAL---ERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEV-- 425
               + L   + + ILE+            KLKDL+Q L  +       Q   L  E+  
Sbjct: 682 QFEKDNLITKQNQLILEI-----------SKLKDLQQSLVNSKSEEMTLQINELQKEIEI 730

Query: 426 -RDSNRRAHKIQGELKNLKSKVFGLENELR 454
            R   +    ++ E++ L+ K   LE +++
Sbjct: 731 LRQEEKEKGTLEQEVQELQLKTELLEKQMK 760



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 88/410 (21%), Positives = 186/410 (45%), Gaps = 63/410 (15%)

Query: 24   KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQ 83
            + LL   Q   A+       L ++ E  K +   Q  LE ++QQ++ ++ E+Q  LS M 
Sbjct: 3088 RSLLSEIQALHAQMNGRKITLKREQESEKPS---QELLEYNIQQKQSQMLEMQVELSSM- 3143

Query: 84   VCLFQEREHVLRLYSENDRLRIREL-----EDKKKIQNLLALVGTDAGEVTYF---CKEP 135
                ++R   L+    ++++ + EL     + K +++  L        E+  F    K+ 
Sbjct: 3144 ----KDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3199

Query: 136  PHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRER-KESSEHYQRDIQT---LIL 191
              +V +L  T+    E ++S    +  + + +K   S ER KE  E  +  +++     L
Sbjct: 3200 TDEVHLLNDTL--ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNL 3257

Query: 192  QVEALQAQLGEQTKLSREQIEG--LIEDRRIHLE-----EIQVQHQRNQNKIKELTKNLH 244
            Q+  L  Q  +    S+++IE   ++ D ++  E     E+QV  +  + +I+E++  L 
Sbjct: 3258 QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLD 3317

Query: 245  HTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMH 304
              +EL         QL+S +   +    L  ++L+ +++      K+ E+K  +++ +++
Sbjct: 3318 REREL-------HAQLQSSDGTGQSRPPLPSEDLLKELQ------KQLEEKHSRIVELLN 3364

Query: 305  ESHHAQSEYIKSL----KDKLVQEKKLSNMYQ---------EQCISLEEELARIREEEGM 351
            E+   + + +++     KD+ V  K L    +          +  S  E+L R  EE+  
Sbjct: 3365 ETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEK-- 3422

Query: 352  RREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKD 401
            R++++K   +  G+RLQ + + ++  E    LE E  +   ++L Q L +
Sbjct: 3423 RQQVYK--LDLEGQRLQGIMQEFQKQE----LEREEKRESRRILYQNLNE 3466



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 100/489 (20%), Positives = 196/489 (40%), Gaps = 86/489 (17%)

Query: 22   PSKELLEYYQKKMAECEAENEDLLKKLELYK-EACEGQHKLECDLQ------QREEE--- 71
            PS++LL+  QK++ E  +   +LL + E YK ++ + + ++E D Q      Q E+E   
Sbjct: 3340 PSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANT 3399

Query: 72   -----IAELQKALSDMQVCLFQEREHVLRLYSENDRL-------RIRELEDKKKIQNLLA 119
                 + ELQ  + D+Q  L ++R+ V +L  E  RL       + +ELE ++K ++   
Sbjct: 3400 EGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRI 3459

Query: 120  LVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSE----------------------- 156
            L        T+       +  +LQ+ I+  GE ++S                        
Sbjct: 3460 LYQNLNEPTTWSLTSDRTRNWVLQQKIE--GETKESNYAKLIEMNGGGTGCNHELEMIRQ 3517

Query: 157  -----SSAFKADPKISKRRPSRERKESSEH--YQRDIQTLILQVEALQAQLGEQTKL-SR 208
                 +S  +  P+ +  R   E  +  +    Q +I  +ILQ++ L  Q GE+  L S 
Sbjct: 3518 KLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSP 3577

Query: 209  EQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKE 268
                G + +R +       Q+      I +LT+  +  + ++ +  +     R     ++
Sbjct: 3578 STSCGSLTERLLR------QNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRD 3631

Query: 269  KSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLS 328
             S    + +L        +   +KE    + L +      A++E  K LK +L  +  L 
Sbjct: 3632 NS---SRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYK-LKAELRNDSLL- 3686

Query: 329  NMYQEQCISLEEELARIREEEG--MRREIFKDRTNKMGKRLQIMTKRYEALERRRI---- 382
                 Q +S + E   ++   G  +R E F+       K L ++   ++  E   +    
Sbjct: 3687 -----QTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLA 3741

Query: 383  -LEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELK- 440
             +  +   TD++V+  + K   +      V+   ++   L+       RR H++ G +  
Sbjct: 3742 RMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLV-------RRWHRVTGSVSI 3794

Query: 441  NLKSKVFGL 449
            N+    FGL
Sbjct: 3795 NINRDGFGL 3803



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 89/391 (22%), Positives = 157/391 (40%), Gaps = 65/391 (16%)

Query: 5    LESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD 64
            L+  P  + E  L    PS+   +  QK++   ++E  DL  ++E  +      +    D
Sbjct: 1072 LDHLPSVTKESSLRATQPSEN--DKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVD 1129

Query: 65   LQQREEEIAELQKALSDM-QVCLFQEREHVLRLYS----ENDRLRIRELEDKKKIQNLLA 119
             Q RE    E  KAL  + +  +F + E +  L      E   ++ +E  D+ K  +LL 
Sbjct: 1130 -QVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLI 1188

Query: 120  --LVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPS--RER 175
              L    + E +YF +      ++L +      +CE +      +   IS+      ++ 
Sbjct: 1189 GKLQKAVSEECSYFLQT---LCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDY 1245

Query: 176  KESSEHYQRDIQTLILQVE-------ALQAQL----GEQT----------KLSREQIEGL 214
            +   + +Q ++ TL+ +V         LQ +L    G+QT           L +E+ E L
Sbjct: 1246 RYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFL 1305

Query: 215  -IEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFL--QLRSENQNKEKSW 271
             I  +  +LE+I V H+   + +++L K     Q    ES    L  QL+   QN E   
Sbjct: 1306 SIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEI 1365

Query: 272  MLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKS--------------- 316
               +  L + + +  V      D +     V+ ES   ++ Y  S               
Sbjct: 1366 HCLQKRLQA-VSESTVPPSLPVDSV-----VITESDAQRTMYPGSCVKKNIDGTIEFSGE 1419

Query: 317  --LKDKLVQEKKLSNMYQEQCISLEEELARI 345
              +K++    K L   YQEQ   LEEE+A++
Sbjct: 1420 FGVKEETNIVKLLEKQYQEQ---LEEEVAKV 1447



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 67/315 (21%), Positives = 135/315 (42%), Gaps = 47/315 (14%)

Query: 58   QHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNL 117
            + +L  D+      I+EL+  + +M   L  E+E V  +  +N       LE +KK+  L
Sbjct: 2594 EDELGSDISALTLRISELESQVVEMHTSLILEKEQV-EIAEKN------VLEKEKKLLEL 2646

Query: 118  LALV-GTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQS----ESSAFKADPKISKRRPS 172
              L+ G +  +     K  P  V +L+ T +     E+S    E  A +A+  ++ +   
Sbjct: 2647 QKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAE-SVATKAEL 2705

Query: 173  RERKESSEHYQRDIQTLILQVEALQ---AQLGEQTKLSREQIEGLIEDRRIHLEEIQVQH 229
               KE +E  Q ++      + +LQ   +Q+ +    ++E++  L ++     +E +VQ 
Sbjct: 2706 ASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKE-----DETEVQE 2760

Query: 230  QRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKD-----NLMSK--- 281
             +     + L   L    + +   T   L++ S NQ  +   +L K+     NL S+   
Sbjct: 2761 SKKACMFEPLPIKL---SKSIASQTDGTLKISSSNQTPQ---ILVKNAGIQINLQSECSS 2814

Query: 282  ------IKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQC 335
                  I Q+  + +K ++     +  M   H +++E +K      VQ      + +E+C
Sbjct: 2815 EEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQ------LLKEEC 2868

Query: 336  ISLEEELARIREEEG 350
             +L+  +  +R +EG
Sbjct: 2869 GTLKAVIQCLRSKEG 2883



 Score = 36.2 bits (82), Expect = 0.063
 Identities = 61/334 (18%), Positives = 136/334 (40%), Gaps = 86/334 (25%)

Query: 193 VEALQAQL-GEQTKLSREQIEGLIEDRRI--------HLEEIQVQHQRNQNKIKELTKNL 243
           +E ++++L G+Q ++  E++   +E+ R+         L+E +   ++    I +LT NL
Sbjct: 157 LEMMESELAGKQHEI--EELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANL 214

Query: 244 HHTQELLYESTKDFLQLRSEN--------------------------------------- 264
              +    E+ ++FL+L  ++                                       
Sbjct: 215 QQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQ 274

Query: 265 -------------QNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGK--------VLPVM 303
                        Q K++ + ++   L  KIK Y ++  KK +   K        ++  +
Sbjct: 275 QQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEEL 334

Query: 304 HESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKM 363
           +     + +    LKDKL    KL    QEQ +   +E+  ++    +     K +  + 
Sbjct: 335 NTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMK----LELTNSKQKERQS 390

Query: 364 GKRLQIMTKRYEALERRRILEVEGFKTDI--KVLRQKLKDLEQMLYKATVNARANQDLAL 421
            + ++ +    E L++R   + + F+TDI  ++ ++  + LEQ+  +A ++    Q +  
Sbjct: 391 SEEIKQLMGTVEELQKRNHKDSQ-FETDIVQRMEQETQRKLEQL--RAELDEMYGQQIV- 446

Query: 422 LCEVRDSNRRAHKIQGELKNLKSKVFG-LENELR 454
             +++    R H  Q  ++ +K++  G +EN LR
Sbjct: 447 --QMKQELIRQHMAQ--MEEMKTRHKGEMENALR 476



 Score = 30.0 bits (66), Expect = 4.5
 Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 15/76 (19%)

Query: 42   EDLLKKLEL--YKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSE 99
            E +  K EL  YKE  E   KL+ +L  +E  +  LQK LS       Q R+H   L   
Sbjct: 2697 ESVATKAELASYKEKAE---KLQEELLVKETNMTSLQKDLS-------QVRDH---LAEA 2743

Query: 100  NDRLRIRELEDKKKIQ 115
             ++L I E ED+ ++Q
Sbjct: 2744 KEKLSILEKEDETEVQ 2759


>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
          Length = 3899

 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 100/482 (20%), Positives = 208/482 (43%), Gaps = 67/482 (13%)

Query: 23   SKEL---LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDL---QQRE-----EE 71
            S+EL   LE  + K+   E  +++ L+ L+   E+ + Q  L+ +L   QQ++     ++
Sbjct: 3209 SRELQWALEKEKAKLGRSEERDKEELEDLKFSLES-QKQRNLQLNLLLEQQKQLLNESQQ 3267

Query: 72   IAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELE---DKKKIQNLLALVGTDAGEV 128
              E Q+ L D Q+   Q R   L++  E++++RIRE+    D+++  +         G+ 
Sbjct: 3268 KIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQ- 3326

Query: 129  TYFCKEPPHKVTILQKTIQAVGECEQS-------ESSAFKADPKISKRRPSRERKESSEH 181
                  PP     L K +Q   E + S       E+  +K D   ++++  ++R+   + 
Sbjct: 3327 ----SRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKT 3382

Query: 182  YQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTK 241
             Q + +      E  +     Q+K+  E ++  +E++R  + ++ ++ QR Q  ++E  K
Sbjct: 3383 LQTEQEA---NTEGQKKMHELQSKV--EDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQK 3437

Query: 242  NLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLP 301
                 QEL  E  ++  ++  +N N+  +W L  D   + + Q +++ + KE    K++ 
Sbjct: 3438 -----QELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIE 3492

Query: 302  VMHESHHAQSEYIKSLKDKL-VQEKKLSNMYQEQCISLEEELARIREEEGMRREI----- 355
             M+      +  ++ ++ KL     KL  + Q+    L+ E A   +   ++  I     
Sbjct: 3493 -MNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIIL 3551

Query: 356  -FKDRTNKMGKRLQIMTKRYE--ALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKA--- 409
              +  T + G+   +++      +L  R + +       I  L ++  DL  M+ K    
Sbjct: 3552 QLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQ 3611

Query: 410  -----------------TVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 452
                             ++N  AN +  +  E    NR    +Q  LK  +++V+ L+ E
Sbjct: 3612 IRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAE 3671

Query: 453  LR 454
            LR
Sbjct: 3672 LR 3673



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 86/465 (18%), Positives = 197/465 (42%), Gaps = 60/465 (12%)

Query: 14   EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACE----GQHKLECDLQQRE 69
            +  + KL    +++  +Q        E E L   L+   + C      + +L+ D+Q+R 
Sbjct: 2084 QQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERN 2143

Query: 70   EEIAELQKALSDM-QVCLFQEREHV------------LRLYSENDRLRIRELEDKKKIQN 116
            EEI +L+  + ++ Q  L ++R+H             ++L +E D +  +E    K+I N
Sbjct: 2144 EEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKE----KEITN 2199

Query: 117  LLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERK 176
            L         ++  F +E  +K   +Q+    + E ++ ES+              +E +
Sbjct: 2200 L-------EEQLEQFREELENKNEEVQQLHMQL-EIQKKESTT-----------RLQELE 2240

Query: 177  ESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKI 236
            + ++ ++ D++ L L ++   A   +   +   +   +I+++ + ++++  Q  + Q ++
Sbjct: 2241 QENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL 2300

Query: 237  KELTKN--LHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKED 294
            K  T N  +    EL+ +       L S+ +         K N   +I+Q     +K + 
Sbjct: 2301 KITTDNKVIEEKNELIRDLETQIECLMSDQE-------CVKRNREEEIEQLNEVIEKLQQ 2353

Query: 295  KIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRRE 354
            ++  +      + H+ SE   SLK +L       ++   + ++LE+++    EE    + 
Sbjct: 2354 ELANIGQKTSMNAHSLSEEADSLKHQL-------DVVIAEKLALEQQVETANEEMTFMKN 2406

Query: 355  IFKD---RTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATV 411
            + K+   + N++ + L  + +  E++E+ + +        I  L +   +LE +L +  +
Sbjct: 2407 VLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDAL 2466

Query: 412  NARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456
             +  NQ      E  +       ++  L  L+S V   + EL  C
Sbjct: 2467 KSLENQTYFKSFE-ENGKGSIINLETRLLQLESTVSAKDLELTQC 2510



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 102/520 (19%), Positives = 216/520 (41%), Gaps = 109/520 (20%)

Query: 27  LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD-------LQQREEEIAELQKAL 79
           +E  QK+  +      D+++++E   +    Q + E D       +Q ++E I +    +
Sbjct: 401 VEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQM 460

Query: 80  SDMQVCLFQEREHVLRLYSE----NDRLRIR---------ELED----KKKIQNLLALVG 122
            +M+     E E+ LR YS      D++++          +L+D    K+K++  L L+ 
Sbjct: 461 EEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLIL 520

Query: 123 TDAGEVTYFCKEPPHKVTI----LQKTIQAVGECEQSESSAFKA-----DPKISKRRPSR 173
            +   +    ++   +++     +Q+  Q + E E   + A K+     D K      S 
Sbjct: 521 EEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASE 580

Query: 174 ERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHL----------- 222
            RKE    ++ ++    +++E L+ +         E  E  +E  R  L           
Sbjct: 581 SRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKL 640

Query: 223 -EEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSK 281
            E+++++H+ N  K+K+    +H+ Q++      D LQ  +E   K ++   EKDNL++K
Sbjct: 641 KEDLEIEHRINIEKLKD-NLGIHYKQQI------DGLQ--NEMSQKIETMQFEKDNLITK 691

Query: 282 IKQYRVQCKKKED------------------KIGKVLPVMHESHHAQSEYIKSLKDKLVQ 323
             Q  ++  K +D                  ++ K + ++ +    +    + +++  ++
Sbjct: 692 QNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLK 751

Query: 324 EKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRIL 383
            + L    +E+   L+E+ A++  E      I KD    +   L+I T      +  R++
Sbjct: 752 TELLEKQMKEKENDLQEKFAQLEAE----NSILKDEKKTLEDMLKIHT---PVSQEERLI 804

Query: 384 EVEGFKT---------DIKVLRQKLKDLEQMLYK--------------ATVNARAN---- 416
            ++  K+         +I++L ++ +DL+Q   +              A  N   N    
Sbjct: 805 FLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQEL 864

Query: 417 -QDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRL 455
            ++ A L +V+D +    K + EL+  KSK+  L  EL L
Sbjct: 865 QEEYACLLKVKD-DLEDSKNKQELE-YKSKLKALNEELHL 902



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 100/510 (19%), Positives = 203/510 (39%), Gaps = 99/510 (19%)

Query: 19  KLHPSKELLEYYQKKMAECEAENEDLLKKLELYK----EACEGQHKLECDLQQREEEIAE 74
           +L     LLE YQKK  +   +   L +K+++Y+    +  E  +K E  +Q++E  I E
Sbjct: 276 QLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEE--IQEKETIIEE 333

Query: 75  L---------------------QKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKK 113
           L                      K L ++Q  + Q+ + +  +  E    + +E +  ++
Sbjct: 334 LNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEE 393

Query: 114 IQNLLALVGT-----------DAGEVTYFCKEPPHKVTILQKTI-----QAVGECEQSES 157
           I+ L+  V             +   V    +E   K+  L+  +     Q + + +Q   
Sbjct: 394 IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELI 453

Query: 158 SAFKADPKISKRRPSRERKESSEHYQR--------------------DIQTLILQVEALQ 197
               A  +  K R   E + +   Y                       +Q    Q E L+
Sbjct: 454 RQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLK 513

Query: 198 AQLG---EQTKLSREQIEGLIEDRRIHLEEIQVQHQ---RNQNKIKELTKNLHHTQELLY 251
            +LG   E+    + Q+E L+E+     E+IQ   Q     ++K+ E  K+L   ++L  
Sbjct: 514 EELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKA 573

Query: 252 ESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQS 311
           E      + R E + K +          +++  Y+++ +  E +   VL  M ES  A+ 
Sbjct: 574 EIV-SASESRKELELKHE----------AEVTNYKIKLEMLEKEKNAVLDRMAESQEAEL 622

Query: 312 EYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMR-REIFKDRTNKMGKRLQIM 370
           E +++ +     E++LS + ++  I     + ++++  G+  ++      N+M ++++ M
Sbjct: 623 ERLRT-QLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETM 681

Query: 371 TKRYEAL---ERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEV-- 425
               + L   + + ILE+            KLKDL+Q L  +       Q   L  E+  
Sbjct: 682 QFEKDNLITKQNQLILEI-----------SKLKDLQQSLVNSKSEEMTLQINELQKEIEI 730

Query: 426 -RDSNRRAHKIQGELKNLKSKVFGLENELR 454
            R   +    ++ E++ L+ K   LE +++
Sbjct: 731 LRQEEKEKGTLEQEVQELQLKTELLEKQMK 760



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 88/410 (21%), Positives = 186/410 (45%), Gaps = 63/410 (15%)

Query: 24   KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQ 83
            + LL   Q   A+       L ++ E  K +   Q  LE ++QQ++ ++ E+Q  LS M 
Sbjct: 3080 RSLLSEIQALHAQMNGRKITLKREQESEKPS---QELLEYNIQQKQSQMLEMQVELSSM- 3135

Query: 84   VCLFQEREHVLRLYSENDRLRIREL-----EDKKKIQNLLALVGTDAGEVTYF---CKEP 135
                ++R   L+    ++++ + EL     + K +++  L        E+  F    K+ 
Sbjct: 3136 ----KDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3191

Query: 136  PHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRER-KESSEHYQRDIQT---LIL 191
              +V +L  T+    E ++S    +  + + +K   S ER KE  E  +  +++     L
Sbjct: 3192 TDEVHLLNDTL--ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNL 3249

Query: 192  QVEALQAQLGEQTKLSREQIEG--LIEDRRIHLE-----EIQVQHQRNQNKIKELTKNLH 244
            Q+  L  Q  +    S+++IE   ++ D ++  E     E+QV  +  + +I+E++  L 
Sbjct: 3250 QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLD 3309

Query: 245  HTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMH 304
              +EL         QL+S +   +    L  ++L+ +++      K+ E+K  +++ +++
Sbjct: 3310 REREL-------HAQLQSSDGTGQSRPPLPSEDLLKELQ------KQLEEKHSRIVELLN 3356

Query: 305  ESHHAQSEYIKSL----KDKLVQEKKLSNMYQ---------EQCISLEEELARIREEEGM 351
            E+   + + +++     KD+ V  K L    +          +  S  E+L R  EE+  
Sbjct: 3357 ETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEK-- 3414

Query: 352  RREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKD 401
            R++++K   +  G+RLQ + + ++  E    LE E  +   ++L Q L +
Sbjct: 3415 RQQVYK--LDLEGQRLQGIMQEFQKQE----LEREEKRESRRILYQNLNE 3458



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 100/489 (20%), Positives = 196/489 (40%), Gaps = 86/489 (17%)

Query: 22   PSKELLEYYQKKMAECEAENEDLLKKLELYK-EACEGQHKLECDLQ------QREEE--- 71
            PS++LL+  QK++ E  +   +LL + E YK ++ + + ++E D Q      Q E+E   
Sbjct: 3332 PSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANT 3391

Query: 72   -----IAELQKALSDMQVCLFQEREHVLRLYSENDRL-------RIRELEDKKKIQNLLA 119
                 + ELQ  + D+Q  L ++R+ V +L  E  RL       + +ELE ++K ++   
Sbjct: 3392 EGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRI 3451

Query: 120  LVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSE----------------------- 156
            L        T+       +  +LQ+ I+  GE ++S                        
Sbjct: 3452 LYQNLNEPTTWSLTSDRTRNWVLQQKIE--GETKESNYAKLIEMNGGGTGCNHELEMIRQ 3509

Query: 157  -----SSAFKADPKISKRRPSRERKESSEH--YQRDIQTLILQVEALQAQLGEQTKL-SR 208
                 +S  +  P+ +  R   E  +  +    Q +I  +ILQ++ L  Q GE+  L S 
Sbjct: 3510 KLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSP 3569

Query: 209  EQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKE 268
                G + +R +       Q+      I +LT+  +  + ++ +  +     R     ++
Sbjct: 3570 STSCGSLTERLLR------QNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRD 3623

Query: 269  KSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLS 328
             S    + +L        +   +KE    + L +      A++E  K LK +L  +  L 
Sbjct: 3624 NS---SRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYK-LKAELRNDSLL- 3678

Query: 329  NMYQEQCISLEEELARIREEEG--MRREIFKDRTNKMGKRLQIMTKRYEALERRRI---- 382
                 Q +S + E   ++   G  +R E F+       K L ++   ++  E   +    
Sbjct: 3679 -----QTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLA 3733

Query: 383  -LEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELK- 440
             +  +   TD++V+  + K   +      V+   ++   L+       RR H++ G +  
Sbjct: 3734 RMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLV-------RRWHRVTGSVSI 3786

Query: 441  NLKSKVFGL 449
            N+    FGL
Sbjct: 3787 NINRDGFGL 3795



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 89/391 (22%), Positives = 157/391 (40%), Gaps = 65/391 (16%)

Query: 5    LESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD 64
            L+  P  + E  L    PS+   +  QK++   ++E  DL  ++E  +      +    D
Sbjct: 1072 LDHLPSVTKESSLRATQPSEN--DKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVD 1129

Query: 65   LQQREEEIAELQKALSDM-QVCLFQEREHVLRLYS----ENDRLRIRELEDKKKIQNLLA 119
             Q RE    E  KAL  + +  +F + E +  L      E   ++ +E  D+ K  +LL 
Sbjct: 1130 -QVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLI 1188

Query: 120  --LVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPS--RER 175
              L    + E +YF +      ++L +      +CE +      +   IS+      ++ 
Sbjct: 1189 GKLQKAVSEECSYFLQT---LCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDY 1245

Query: 176  KESSEHYQRDIQTLILQVE-------ALQAQL----GEQT----------KLSREQIEGL 214
            +   + +Q ++ TL+ +V         LQ +L    G+QT           L +E+ E L
Sbjct: 1246 RYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFL 1305

Query: 215  -IEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFL--QLRSENQNKEKSW 271
             I  +  +LE+I V H+   + +++L K     Q    ES    L  QL+   QN E   
Sbjct: 1306 SIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEI 1365

Query: 272  MLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKS--------------- 316
               +  L + + +  V      D +     V+ ES   ++ Y  S               
Sbjct: 1366 HCLQKRLQA-VSESTVPPSLPVDSV-----VITESDAQRTMYPGSCVKKNIDGTIEFSGE 1419

Query: 317  --LKDKLVQEKKLSNMYQEQCISLEEELARI 345
              +K++    K L   YQEQ   LEEE+A++
Sbjct: 1420 FGVKEETNIVKLLEKQYQEQ---LEEEVAKV 1447



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 67/315 (21%), Positives = 135/315 (42%), Gaps = 47/315 (14%)

Query: 58   QHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNL 117
            + +L  D+      I+EL+  + +M   L  E+E V  +  +N       LE +KK+  L
Sbjct: 2586 EDELGSDISALTLRISELESQVVEMHTSLILEKEQV-EIAEKN------VLEKEKKLLEL 2638

Query: 118  LALV-GTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQS----ESSAFKADPKISKRRPS 172
              L+ G +  +     K  P  V +L+ T +     E+S    E  A +A+  ++ +   
Sbjct: 2639 QKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAE-SVATKAEL 2697

Query: 173  RERKESSEHYQRDIQTLILQVEALQ---AQLGEQTKLSREQIEGLIEDRRIHLEEIQVQH 229
               KE +E  Q ++      + +LQ   +Q+ +    ++E++  L ++     +E +VQ 
Sbjct: 2698 ASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKE-----DETEVQE 2752

Query: 230  QRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKD-----NLMSK--- 281
             +     + L   L    + +   T   L++ S NQ  +   +L K+     NL S+   
Sbjct: 2753 SKKACMFEPLPIKL---SKSIASQTDGTLKISSSNQTPQ---ILVKNAGIQINLQSECSS 2806

Query: 282  ------IKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQC 335
                  I Q+  + +K ++     +  M   H +++E +K      VQ      + +E+C
Sbjct: 2807 EEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQ------LLKEEC 2860

Query: 336  ISLEEELARIREEEG 350
             +L+  +  +R +EG
Sbjct: 2861 GTLKAVIQCLRSKEG 2875



 Score = 36.2 bits (82), Expect = 0.063
 Identities = 61/334 (18%), Positives = 136/334 (40%), Gaps = 86/334 (25%)

Query: 193 VEALQAQL-GEQTKLSREQIEGLIEDRRI--------HLEEIQVQHQRNQNKIKELTKNL 243
           +E ++++L G+Q ++  E++   +E+ R+         L+E +   ++    I +LT NL
Sbjct: 157 LEMMESELAGKQHEI--EELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANL 214

Query: 244 HHTQELLYESTKDFLQLRSEN--------------------------------------- 264
              +    E+ ++FL+L  ++                                       
Sbjct: 215 QQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQ 274

Query: 265 -------------QNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGK--------VLPVM 303
                        Q K++ + ++   L  KIK Y ++  KK +   K        ++  +
Sbjct: 275 QQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEEL 334

Query: 304 HESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKM 363
           +     + +    LKDKL    KL    QEQ +   +E+  ++    +     K +  + 
Sbjct: 335 NTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMK----LELTNSKQKERQS 390

Query: 364 GKRLQIMTKRYEALERRRILEVEGFKTDI--KVLRQKLKDLEQMLYKATVNARANQDLAL 421
            + ++ +    E L++R   + + F+TDI  ++ ++  + LEQ+  +A ++    Q +  
Sbjct: 391 SEEIKQLMGTVEELQKRNHKDSQ-FETDIVQRMEQETQRKLEQL--RAELDEMYGQQIV- 446

Query: 422 LCEVRDSNRRAHKIQGELKNLKSKVFG-LENELR 454
             +++    R H  Q  ++ +K++  G +EN LR
Sbjct: 447 --QMKQELIRQHMAQ--MEEMKTRHKGEMENALR 476



 Score = 30.0 bits (66), Expect = 4.5
 Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 15/76 (19%)

Query: 42   EDLLKKLEL--YKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSE 99
            E +  K EL  YKE  E   KL+ +L  +E  +  LQK LS       Q R+H   L   
Sbjct: 2689 ESVATKAELASYKEKAE---KLQEELLVKETNMTSLQKDLS-------QVRDH---LAEA 2735

Query: 100  NDRLRIRELEDKKKIQ 115
             ++L I E ED+ ++Q
Sbjct: 2736 KEKLSILEKEDETEVQ 2751


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 93/456 (20%), Positives = 205/456 (44%), Gaps = 61/456 (13%)

Query: 20   LHPSKELLEYYQKKMAECEAENEDLLKKLEL-YKEACEGQHKLECDLQQREEEIAELQKA 78
            L    + L+   K++     E E+ LK      KE  E  ++L  +L ++E EI+ +QK 
Sbjct: 1454 LQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQ 1513

Query: 79   LSDMQVCLFQEREHVLRLYSENDRLRIREL--------------EDKKKIQNLLALVGTD 124
            L  +   L   +  +  +Y + ++  I+++              E +K   + L  + + 
Sbjct: 1514 LEAINDKL---QNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESK 1570

Query: 125  AGEVTYFCKEPPHKVTIL---QKTIQAVGECEQSESSAFKADPK--ISKRRPSRERKESS 179
              E+T   +E   ++ I+   ++ ++ V E  Q E    K + K  ++K + S+E++   
Sbjct: 1571 MLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKE--- 1627

Query: 180  EHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKEL 239
              YQ    T + + +    ++        E ++   E ++++LE I+ ++ R       L
Sbjct: 1628 --YQFLKMTAVNETQEKMCEI--------EHLKEQFETQKLNLENIETENIR-------L 1670

Query: 240  TKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKV 299
            T+ LH   E +   TK+    R + ++ E++  +E+D L   +++   +  +K+++    
Sbjct: 1671 TQILHENLEEMRSVTKE----RDDLRSVEETLKVERDQLKENLRETITRDLEKQEE---- 1722

Query: 300  LPVMHESHHAQSEYIKSLKDKLVQEK--KLSNMYQE---QCISLEEELARIREEEGMRRE 354
            L ++H       E I  L+  +V EK  ++SNM ++      +L+ +  +I+EE  +   
Sbjct: 1723 LKIVHMHLKEHQETIDKLRG-IVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHM 1781

Query: 355  IFKDRTNKMGKRLQIMTKRYEALER-RRILEVEGFKTDIKVLRQKLKDLEQMLYKATVN- 412
              K++   + K   I++++ + L   ++ LE    K   K+   K  + + +  K  VN 
Sbjct: 1782 HLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNE 1841

Query: 413  --ARANQDLALLCEVRDSNRRAHKIQGELKNLKSKV 446
               + ++   L  +++D +    K++ E  NL  K+
Sbjct: 1842 TQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKL 1877



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 102/495 (20%), Positives = 210/495 (42%), Gaps = 76/495 (15%)

Query: 5    LESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD 64
            L+ T +   ++++ ++   KE  E  +  +   E EN  L + L    E      K   D
Sbjct: 1631 LKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDD 1690

Query: 65   LQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIREL---EDKKKIQNLLALV 121
            L+  EE +   +  L +        RE + R   + + L+I  +   E ++ I  L  +V
Sbjct: 1691 LRSVEETLKVERDQLKE------NLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIV 1744

Query: 122  GTDAGEVTYFCKEPPHKVTILQ-KTIQAVGECEQSESSAFKADPKISKRRP-SRERKESS 179
                 E++   K+  H    L+ + ++   E   +     +    I K R    E+ +  
Sbjct: 1745 SEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKL 1804

Query: 180  EHYQRD-------IQTLILQVEALQAQL--------GEQTKLSR-EQIEGLIEDRRIHLE 223
             + Q+D       +Q  I +++A + QL          Q K+S  EQ++  I+D+ + L 
Sbjct: 1805 SNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLS 1864

Query: 224  EIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNL----- 278
            +++++   N N  ++L +NL        E  K  ++ R   +  E++  LE+D L     
Sbjct: 1865 KLEIE---NLNLAQKLHENL--------EEMKSVMKERDNLRRVEETLKLERDQLKESLQ 1913

Query: 279  ---------MSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSL-KDKLVQEKKLS 328
                       ++K  R+  K+ ++ + K+   + E     S+  K L K K   +KK+ 
Sbjct: 1914 ETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQ 1973

Query: 329  NMYQE--QCISLEEEL----ARIREEEGMRREIFKDRTNKMGKRL---QIMTKRYEALER 379
             + ++  Q + ++E++     +I E E ++++      +    R+   Q+  K +E+LE 
Sbjct: 1974 ELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEE 2033

Query: 380  RRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGEL 439
             RI+  E  + +++ +++ LK               +Q +A L E+   +R+ H+++ E 
Sbjct: 2034 IRIVAKE--RDELRRIKESLK------------MERDQFIATLREMIARDRQNHQVKPEK 2079

Query: 440  KNLKSKVFGLENELR 454
            + L      L   LR
Sbjct: 2080 RLLSDGQQHLTESLR 2094



 Score = 58.9 bits (141), Expect = 9e-09
 Identities = 98/506 (19%), Positives = 205/506 (40%), Gaps = 80/506 (15%)

Query: 25   ELLEYYQKKMAECEAENE--DLLKKLELYKEACEGQHKLECDLQ-QREEEIAELQKALSD 81
            E++E  +K  +  + +NE   +L+ +   KE  +   K   ++  + +EE+  L   L  
Sbjct: 1037 EIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKK 1096

Query: 82   MQVCLFQEREHVLRLYSENDRL--RIRELEDKKK---------------IQNLLALVGTD 124
             Q  + QE+ H ++   E  R   R+ E+E+K K               +Q  ++ +   
Sbjct: 1097 QQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKK 1156

Query: 125  AGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQR 184
              E+     E  +K   L+       E  Q  +  ++    I+K R   +  + S   +R
Sbjct: 1157 INEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETER 1216

Query: 185  D-IQTLILQVEALQAQLGEQTKLS----REQIEGLIEDRR---------IHLEEIQVQHQ 230
            D ++  I ++EA   Q  E+ K++    +E  E + E RR         I+ ++++  H 
Sbjct: 1217 DHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHT 1276

Query: 231  RNQNKIKEL---------TKNLHHTQELLYE--------STKDFLQLR------------ 261
            + Q +I  L          K +  TQE + E        +TKD   L             
Sbjct: 1277 KLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEK 1336

Query: 262  -SENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLK-- 318
              E+Q + KS   E+DNL +  +   V+  + ++ I + L  + ES   Q + +   +  
Sbjct: 1337 FQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKD 1396

Query: 319  ---DKLVQEKKLSNMYQEQCISLEEEL----ARIREEEGMRREIFKDRTNKMGKRLQIMT 371
                K+V E +         + +E E+     R++E     + + K++ +    +  + +
Sbjct: 1397 NETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQS 1456

Query: 372  KRYEALERRRILEVEGFKT--DIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSN 429
            +  +  E  + +  +  +T  ++KV    LK+ E+ + +  VN    +      E+    
Sbjct: 1457 ESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKE-----TEISTIQ 1511

Query: 430  RRAHKIQGELKNLKSKVFGLENELRL 455
            ++   I  +L+N   +++  E +  +
Sbjct: 1512 KQLEAINDKLQNKIQEIYEKEEQFNI 1537



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 97/502 (19%), Positives = 199/502 (39%), Gaps = 101/502 (20%)

Query: 31   QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEI------------------ 72
            ++KM E     + +   ++LY+   E + K++ DL++  +                    
Sbjct: 652  KEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKD 711

Query: 73   ----AELQKALSDMQVCLFQE-------REHVL------RLYSENDRLRIRELEDKKKIQ 115
                 EL+  ++D+Q  L +E       RE V+       L SE +RLR +E++DK +  
Sbjct: 712  LLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLR-KEIQDKSEEL 770

Query: 116  NLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQ----SESSAFKADPKISKRRP 171
            +++        E      E  HK + +Q  ++ +G+ +     ++S+    D +    + 
Sbjct: 771  HII------TSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKT 824

Query: 172  SR---ERK-----ESSEHYQRDIQTLILQVEALQAQLGE-QTKLSREQIE-----GLIED 217
                 E+K     E +E   ++I  L  + +   + LG  +T+LS +  E       +++
Sbjct: 825  LHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQE 884

Query: 218  RRIHLEEIQVQHQRNQNKIKELTKNLHHTQELL---YESTKDFLQLRSENQNKEKSWMLE 274
            R   +E+++ Q +   + ++ + +      E L    E  K   Q + + +  ++S  +E
Sbjct: 885  RLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIE 944

Query: 275  KDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQ 334
            +D L S I          ++++   L    ES     E I +LK K+ +E   +      
Sbjct: 945  RDQLKSDIHDTVNMNIDTQEQLRNAL----ESLKQHQETINTLKSKISEEVSRN------ 994

Query: 335  CISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMT---KRYEALERRR---------- 381
             + +EE     ++E   +      + +   K  Q +T   K  E +E++R          
Sbjct: 995  -LHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKN 1053

Query: 382  ---------ILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRA 432
                     I E E  KTD+K   +   + ++ L       +  Q++     V      A
Sbjct: 1054 ELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEI-----VAQEKNHA 1108

Query: 433  HKIQGELKNLKSKVFGLENELR 454
             K +GEL     ++  +E +L+
Sbjct: 1109 IKKEGELSRTCDRLAEVEEKLK 1130



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 76/411 (18%), Positives = 180/411 (43%), Gaps = 36/411 (8%)

Query: 19   KLHPSKELLEYYQKKMAECEAEN----EDLLKKLELYKEACEGQHKLECDLQQREEEIAE 74
            ++ P K LL   Q+ + E   E     ++LLK+     +  E  ++L  DL++  E   E
Sbjct: 2074 QVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKE 2133

Query: 75   LQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKE 134
            L   +       + + +H+ +L++ N R  +      KK++ +L+ V           KE
Sbjct: 2134 LSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTK--------IKE 2185

Query: 135  PPHKVTILQKTIQAVGECEQSESSAFKADP-KISKRRPSRERKESSEHYQRDIQTLILQV 193
              H+ +I +  +  + E E+ +    K    +     PSRE ++   +   D+    +  
Sbjct: 2186 EQHE-SINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILK 2244

Query: 194  EALQAQLG------EQTKLSREQIEGLIED---RRIHLEEIQVQHQRNQNKIKELTKNLH 244
            +  +++        +Q   +R+++   +E+    R  +E+++   Q+  ++I ++    +
Sbjct: 2245 DFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFN 2304

Query: 245  HTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMH 304
            +    +   + +F + RS   +KE  W  +  +L  K ++     +  +  +     V  
Sbjct: 2305 NRIIAIMNESTEF-EERSATISKE--WEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNP 2361

Query: 305  ESHHAQSEYIKSLKDKLVQEK--KLSNMY---QEQCISLEEELARIREEEGMRREI---F 356
             +   ++ ++ S   +L  EK  +L N     +E  +  E ++ ++++E  +  +I    
Sbjct: 2362 TTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKL 2421

Query: 357  KDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLK--DLEQM 405
            + + ++  K L+   +  + L+ +  L  + +K +I+ L+ KL   DLE+M
Sbjct: 2422 QAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKM 2472



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 69/386 (17%), Positives = 165/386 (42%), Gaps = 43/386 (11%)

Query: 24   KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAE-LQKALSDM 82
            K  L Y  +++ E   E ++ L ++E  KE  E +      +++ +  I E LQ+ L ++
Sbjct: 865  KTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEV 924

Query: 83   QVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTIL 142
            +  L QE++ + +L    + L+I   + K  I + + +                  +   
Sbjct: 925  KT-LTQEKDDLKQL---QESLQIERDQLKSDIHDTVNM-----------------NIDTQ 963

Query: 143  QKTIQAVGECEQSESSAFKADPKISKR-RPSRERKESSEHYQRDIQTLILQVEALQAQLG 201
            ++   A+   +Q + +      KIS+    +   +E++   + + Q  ++ ++  Q    
Sbjct: 964  EQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEA 1023

Query: 202  EQTKLSREQIEG--LIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQ 259
            + T+     ++   +IE +R     IQ      +N+++++ +++   +E L    K+ ++
Sbjct: 1024 KNTQTLTADVKDNEIIEQQRKIFSLIQ-----EKNELQQMLESVIAEKEQLKTDLKENIE 1078

Query: 260  LRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKD 319
            +  ENQ + +    E       + Q +    KKE ++ +    + E      E  + L++
Sbjct: 1079 MTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQE 1138

Query: 320  KLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALER 379
            K           Q+Q ++++EE++ ++++      +  +  NK      + T+R E  ++
Sbjct: 1139 K-----------QQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQK 1187

Query: 380  --RRILEVEGFKTDIKVLRQKLKDLE 403
                  EV+    + KVL++  K  E
Sbjct: 1188 LNENYEEVKSITKERKVLKELQKSFE 1213



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 84/439 (19%), Positives = 185/439 (42%), Gaps = 52/439 (11%)

Query: 14   EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEI- 72
            ++RL ++   KE LE     +   E E   + +KL+   E  +   + + DL+Q +E + 
Sbjct: 883  QERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQ 942

Query: 73   AELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFC 132
             E  +  SD+   +    +   +L +  + L+    + ++ I  L + +  +     +  
Sbjct: 943  IERDQLKSDIHDTVNMNIDTQEQLRNALESLK----QHQETINTLKSKISEEVSRNLHME 998

Query: 133  KEPPHKVTILQKTIQAVG---ECEQSESSAFKADPK----ISKRRPSRERKESSEHYQRD 185
            +         Q+ +  +    + E   +    AD K    I ++R      +     Q+ 
Sbjct: 999  ENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQM 1058

Query: 186  IQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHH 245
            ++++I + E L+  L       +E IE  IE               NQ +++ L   L  
Sbjct: 1059 LESVIAEKEQLKTDL-------KENIEMTIE---------------NQEELRLLGDELKK 1096

Query: 246  TQELLYESTKDFLQLRSE-NQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMH 304
             QE++ +     ++   E ++  ++   +E+     K+K+   Q ++K+ ++  V   M 
Sbjct: 1097 QQEIVAQEKNHAIKKEGELSRTCDRLAEVEE-----KLKEKSQQLQEKQQQLLNVQEEMS 1151

Query: 305  ESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMG 364
            E     +E I++LK++L  ++      + + + L ++L    EE    + I K+R  K+ 
Sbjct: 1152 EMQKKINE-IENLKNELKNKELTLEHMETERLELAQKLNENYEEV---KSITKER--KVL 1205

Query: 365  KRLQ--IMTKRYEALERRRILEVEGFKT--DIKVLRQKLKDLEQMLYKATVNARANQDLA 420
            K LQ    T+R       R +E  G +T  ++K+    LK+ ++ + +  +    ++  A
Sbjct: 1206 KELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDE--LRRSVSEKTA 1263

Query: 421  LLCEVRDSNRRAHKIQGEL 439
             +   +D  +   K+Q E+
Sbjct: 1264 QIINTQDLEKSHTKLQEEI 1282


>gi|8922940 gamma-taxilin [Homo sapiens]
          Length = 528

 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 91/409 (22%), Positives = 175/409 (42%), Gaps = 57/409 (13%)

Query: 35  AECEAENEDLLKKLELYKEACEGQHKLECDLQQRE---EEIAELQKALSDMQVCLFQERE 91
           A C  E+ + +   E   +  +GQ   EC+  + +   +E+  L +AL+ +        E
Sbjct: 99  AYCTQESREEIPGGEARTDPPDGQQDSECNRNKEKTLGKEVLLLMQALNTLST----PEE 154

Query: 92  HVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGE 151
            +  L  +   L    LE+ + +Q  + ++     ++    KE  H  +   K I A  +
Sbjct: 155 KLAALCKKYADL----LEESRSVQKQMKILQKKQAQIV---KEKVHLQSEHSKAILARSK 207

Query: 152 CE------QSESSAFKADPKISKRRPSRERKESSEHYQ---RDIQTLILQVEALQAQLGE 202
            E      Q  +   K +     R     RKE++ H+Q    +IQ  + Q +   A+L +
Sbjct: 208 LESLCRELQRHNKTLKEENMQQAREEEERRKEATAHFQITLDEIQAQLEQHDIHNAKLRQ 267

Query: 203 QTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRS 262
           +     E+++ LIE   +  E I    +R + + + +   L  T +L+ E+         
Sbjct: 268 ENIELGEKLKKLIEQYALREEHIDKVFKRKELQQQLVDAKLQQTTQLIKEA--------D 319

Query: 263 ENQNKEKSWML----EKDNLMSKIKQYRVQCKKK----EDKIGKVLPVMHESHHAQSEYI 314
           E   +E+ ++L    E  +   ++KQ  VQ K++     DK  +    M +S+   + + 
Sbjct: 320 EKHQREREFLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFR 379

Query: 315 KSLKDKLVQEKKLSN---MYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMT 371
           + ++    + KKL     +++ +  +  + L ++ EE+ +R        +K  K LQI  
Sbjct: 380 QEMEKMTKKIKKLEKETIIWRTKWENNNKALLQMAEEKTVR--------DKEYKALQIKL 431

Query: 372 KRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420
           +R E L R    E       ++VL+      EQ+  KA + A AN+DLA
Sbjct: 432 ERLEKLCRALQTERNELNEKVEVLK------EQVSIKAAIKA-ANRDLA 473



 Score = 35.8 bits (81), Expect = 0.083
 Identities = 58/240 (24%), Positives = 105/240 (43%), Gaps = 29/240 (12%)

Query: 204 TKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSE 263
           T+ SRE+I G   + R    + Q   + N+NK K L K +    + L  +T    + +  
Sbjct: 102 TQESREEIPG--GEARTDPPDGQQDSECNRNKEKTLGKEVLLLMQAL--NTLSTPEEKLA 157

Query: 264 NQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQ 323
              K+ + +LE+   + K  Q ++  KK+         ++ E  H QSE+ K++  +   
Sbjct: 158 ALCKKYADLLEESRSVQK--QMKILQKKQAQ-------IVKEKVHLQSEHSKAILARSKL 208

Query: 324 EKKLSNMYQEQCISLEEELARIREEEGMRREI---FKDRTNKMGKRLQIMTKRYEALERR 380
           E     + +      EE + + REEE  R+E    F+   +++  +L+        L + 
Sbjct: 209 ESLCRELQRHNKTLKEENMQQAREEEERRKEATAHFQITLDEIQAQLEQHDIHNAKLRQE 268

Query: 381 RILEVEGFKTDIK--VLRQ-------KLKDLEQMLYKATVNARANQDLALLCEVRDSNRR 431
            I   E  K  I+   LR+       K K+L+Q L    V+A+  Q   L+ E  + ++R
Sbjct: 269 NIELGEKLKKLIEQYALREEHIDKVFKRKELQQQL----VDAKLQQTTQLIKEADEKHQR 324


>gi|58535453 CDK5 regulatory subunit associated protein 2 isoform b
           [Homo sapiens]
          Length = 1814

 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 99/419 (23%), Positives = 177/419 (42%), Gaps = 65/419 (15%)

Query: 31  QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA-------ELQKALSDMQ 83
           ++K  E EA   +  K+   ++E  +    LE DL+++E EIA       +  KA+  + 
Sbjct: 268 EEKERETEAAQMEHQKERNSFEERIQA---LEEDLREKEREIATEKKNSLKRDKAIQGLT 324

Query: 84  VCLFQEREHVLRLYSENDRL-----RIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHK 138
           + L  + + V  L SE ++L     + RE   K + Q      G++  E     KE    
Sbjct: 325 MALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQ---GSEDYETALSGKEALSA 381

Query: 139 VTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESS-EHYQRD-------IQTLI 190
               Q   ++  E  +   S  K   ++S  +  RER E   E   R+       I+ L 
Sbjct: 382 ALRSQNLTKST-ENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLR 440

Query: 191 LQVEALQAQLGEQTKLSREQIEGLIED--RRIHLEEIQVQHQRNQNKIKELT------KN 242
            +VE L+ ++ E+ K    + + L+ +  +++H +E  ++H       K++       K+
Sbjct: 441 NEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKD 500

Query: 243 LHHTQELLYESTKDFLQLRSENQNKEK---------SWMLEKDNLMSKIKQYRVQCKKKE 293
           L   Q+  Y    + L+LRSE    EK           +  K+   S   +  +Q  KKE
Sbjct: 501 LEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKE 560

Query: 294 DKIG----KVLPVMHESHHAQSEYIK--SLKDKLVQEKKLSNMYQEQCISLEEELARIRE 347
             I     K L      ++ Q+E  K  +L+ +L Q+      YQ    +LEE+++ IR 
Sbjct: 561 QDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVL---SYQNLRKTLEEQISEIRR 617

Query: 348 EEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQML 406
            E     ++ D+T+ +             LE     +VE F  +   L++K+ DL Q++
Sbjct: 618 REEESFSLYSDQTSYLS----------ICLEENNRFQVEHFSQE--ELKKKVSDLIQLV 664



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 74/341 (21%), Positives = 147/341 (43%), Gaps = 67/341 (19%)

Query: 168 KRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKL---SREQIEGLIEDRRIHLEE 224
           + R  +E    +EH  +    L ++VE+L+ +L E+ +L   + + +E L E     ++ 
Sbjct: 85  EERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQR 144

Query: 225 IQVQHQRNQNKIKELT--------KNLHHTQELLYES-----TKDFLQLRSENQNKEKSW 271
           ++   ++   ++++L         K++   Q  L ++     T+  L+LR E++  E   
Sbjct: 145 VKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK 204

Query: 272 MLEKDNLMS-----------------KIKQYRVQCKKKEDKIGKVLPVMHESH------- 307
           M E D  M+                 K K+  +QC  KE+K     P  + S        
Sbjct: 205 MHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQC-LKEEKSQMACPDENVSSGELRGLC 263

Query: 308 -HAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTN--KMG 364
              + E  +  +   ++ +K  N ++E+  +LEE+L   RE+E   REI  ++ N  K  
Sbjct: 264 AAPREEKERETEAAQMEHQKERNSFEERIQALEEDL---REKE---REIATEKKNSLKRD 317

Query: 365 KRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKA-TVNARANQDL---- 419
           K +Q +T   ++ E++    VE   ++I+ L        + L KA T   + ++D     
Sbjct: 318 KAIQGLTMALKSKEKK----VEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETAL 373

Query: 420 ----ALLCEVRDSN----RRAHKIQGELKNLKSKVFGLENE 452
               AL   +R  N       H+++  +K +  ++  L+ E
Sbjct: 374 SGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQE 414



 Score = 34.3 bits (77), Expect = 0.24
 Identities = 22/98 (22%), Positives = 49/98 (50%), Gaps = 17/98 (17%)

Query: 310  QSEYIKSLK------DKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKM 363
            Q  Y+K +K       +++  + L N+ Q+    LEE+  ++++E+ +  ++F +  N  
Sbjct: 1176 QVRYVKHVKILGPLAPEMIDSRVLENLKQQ----LEEQEYKLQKEQNLNMQLFSEIHNLQ 1231

Query: 364  GKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKD 401
             K   +   RY++L       V+    ++ + RQ++KD
Sbjct: 1232 NKFRDLSPPRYDSL-------VQSQARELSLQRQQIKD 1262


>gi|58535451 CDK5 regulatory subunit associated protein 2 isoform a
           [Homo sapiens]
          Length = 1893

 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 99/419 (23%), Positives = 177/419 (42%), Gaps = 65/419 (15%)

Query: 31  QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA-------ELQKALSDMQ 83
           ++K  E EA   +  K+   ++E  +    LE DL+++E EIA       +  KA+  + 
Sbjct: 268 EEKERETEAAQMEHQKERNSFEERIQA---LEEDLREKEREIATEKKNSLKRDKAIQGLT 324

Query: 84  VCLFQEREHVLRLYSENDRL-----RIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHK 138
           + L  + + V  L SE ++L     + RE   K + Q      G++  E     KE    
Sbjct: 325 MALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQ---GSEDYETALSGKEALSA 381

Query: 139 VTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESS-EHYQRD-------IQTLI 190
               Q   ++  E  +   S  K   ++S  +  RER E   E   R+       I+ L 
Sbjct: 382 ALRSQNLTKST-ENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLR 440

Query: 191 LQVEALQAQLGEQTKLSREQIEGLIED--RRIHLEEIQVQHQRNQNKIKELT------KN 242
            +VE L+ ++ E+ K    + + L+ +  +++H +E  ++H       K++       K+
Sbjct: 441 NEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKD 500

Query: 243 LHHTQELLYESTKDFLQLRSENQNKEK---------SWMLEKDNLMSKIKQYRVQCKKKE 293
           L   Q+  Y    + L+LRSE    EK           +  K+   S   +  +Q  KKE
Sbjct: 501 LEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKE 560

Query: 294 DKIG----KVLPVMHESHHAQSEYIK--SLKDKLVQEKKLSNMYQEQCISLEEELARIRE 347
             I     K L      ++ Q+E  K  +L+ +L Q+      YQ    +LEE+++ IR 
Sbjct: 561 QDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVL---SYQNLRKTLEEQISEIRR 617

Query: 348 EEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQML 406
            E     ++ D+T+ +             LE     +VE F  +   L++K+ DL Q++
Sbjct: 618 REEESFSLYSDQTSYLS----------ICLEENNRFQVEHFSQE--ELKKKVSDLIQLV 664



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 74/341 (21%), Positives = 147/341 (43%), Gaps = 67/341 (19%)

Query: 168 KRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKL---SREQIEGLIEDRRIHLEE 224
           + R  +E    +EH  +    L ++VE+L+ +L E+ +L   + + +E L E     ++ 
Sbjct: 85  EERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQR 144

Query: 225 IQVQHQRNQNKIKELT--------KNLHHTQELLYES-----TKDFLQLRSENQNKEKSW 271
           ++   ++   ++++L         K++   Q  L ++     T+  L+LR E++  E   
Sbjct: 145 VKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK 204

Query: 272 MLEKDNLMS-----------------KIKQYRVQCKKKEDKIGKVLPVMHESH------- 307
           M E D  M+                 K K+  +QC  KE+K     P  + S        
Sbjct: 205 MHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQC-LKEEKSQMACPDENVSSGELRGLC 263

Query: 308 -HAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTN--KMG 364
              + E  +  +   ++ +K  N ++E+  +LEE+L   RE+E   REI  ++ N  K  
Sbjct: 264 AAPREEKERETEAAQMEHQKERNSFEERIQALEEDL---REKE---REIATEKKNSLKRD 317

Query: 365 KRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKA-TVNARANQDL---- 419
           K +Q +T   ++ E++    VE   ++I+ L        + L KA T   + ++D     
Sbjct: 318 KAIQGLTMALKSKEKK----VEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETAL 373

Query: 420 ----ALLCEVRDSN----RRAHKIQGELKNLKSKVFGLENE 452
               AL   +R  N       H+++  +K +  ++  L+ E
Sbjct: 374 SGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQE 414



 Score = 37.7 bits (86), Expect = 0.022
 Identities = 39/151 (25%), Positives = 75/151 (49%), Gaps = 18/151 (11%)

Query: 66   QQREEEIAELQKALSDMQVCLFQEREHVLRLYS----ENDRLRIRELEDKKKIQNLLALV 121
            + +++E  +L+++LS   V L    EH+ R Y+    EN+RL+    E ++  Q L+  V
Sbjct: 1471 RDKQKENDKLRESLSRKTVSL----EHLQREYASVKEENERLQKEGSEKERHNQQLIQEV 1526

Query: 122  GTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEH 181
                 E++   +E    V + Q+ +    +  QS     KA  K+ +    R R+ S E 
Sbjct: 1527 RCSGQELSRVQEE----VKLRQQLLSQNDKLLQSLRVELKAYEKLDEEH-RRLREASGEG 1581

Query: 182  YQ-----RDIQTLILQVEALQAQLGEQTKLS 207
            ++     RD+ +L+++++AL+ QL    + S
Sbjct: 1582 WKGQDPFRDLHSLLMEIQALRLQLERSIETS 1612



 Score = 34.3 bits (77), Expect = 0.24
 Identities = 22/98 (22%), Positives = 49/98 (50%), Gaps = 17/98 (17%)

Query: 310  QSEYIKSLK------DKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKM 363
            Q  Y+K +K       +++  + L N+ Q+    LEE+  ++++E+ +  ++F +  N  
Sbjct: 1176 QVRYVKHVKILGPLAPEMIDSRVLENLKQQ----LEEQEYKLQKEQNLNMQLFSEIHNLQ 1231

Query: 364  GKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKD 401
             K   +   RY++L       V+    ++ + RQ++KD
Sbjct: 1232 NKFRDLSPPRYDSL-------VQSQARELSLQRQQIKD 1262


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 62.4 bits (150), Expect = 8e-10
 Identities = 91/429 (21%), Positives = 183/429 (42%), Gaps = 70/429 (16%)

Query: 14   EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLE--LYKEACEGQH------KLECDL 65
            EDR+A+   +    E   K +A+ + ++E ++  LE  L +E  + Q       KLE D 
Sbjct: 998  EDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057

Query: 66   QQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDA 125
                ++IAELQ  ++++++ L ++ E                     ++Q  LA V  +A
Sbjct: 1058 TDLSDQIAELQAQIAELKMQLAKKEE---------------------ELQAALARVEEEA 1096

Query: 126  GEVTYFCKEPPHKVTILQKTIQAVGECEQSE-SSAFKADPKISKRRPSRERKESSEHYQR 184
             +     K    K+  L+  I  + E  +SE +S  KA+    ++R   E  E+ +    
Sbjct: 1097 AQKNMALK----KIRELESQISELQEDLESERASRNKAE---KQKRDLGEELEALKTELE 1149

Query: 185  DIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLH 244
            D        + L+++  ++  + ++ +E   E+ + H  +IQ   Q++   ++EL + L 
Sbjct: 1150 DTLDSTAAQQELRSKREQEVNILKKTLE---EEAKTHEAQIQEMRQKHSQAVEELAEQLE 1206

Query: 245  HTQEL-----------------LYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRV 287
             T+ +                 L    K  LQ + ++++K K    +   L  K  +   
Sbjct: 1207 QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGER 1266

Query: 288  QCKKKEDKIGK-------VLPVMHESHHAQSEYIK---SLKDKLVQEKKLSNMYQEQCIS 337
               +  DK+ K       V  ++ +S    S+  K   +L+ +L   ++L      Q +S
Sbjct: 1267 VRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLS 1326

Query: 338  LEEELARIREEE-GMRREIFKDRTNKMGKRLQIMTKRYEALERRRILE--VEGFKTDIKV 394
            L  +L ++ +E+   R ++ ++   K     QI T   +  + ++ +E  V   +T  +V
Sbjct: 1327 LSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEV 1386

Query: 395  LRQKLKDLE 403
             R+  KDLE
Sbjct: 1387 KRKLQKDLE 1395



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 64/292 (21%), Positives = 136/292 (46%), Gaps = 24/292 (8%)

Query: 173  RERKESSEHYQRDIQTLILQVEA----LQAQLGEQTKL--SREQIEGLIEDRRIHLEEIQ 226
            RE++ ++E+   +++TL  Q+ A    LQ QL  +T+L    E++   +  ++  LEEI 
Sbjct: 858  REKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEIC 917

Query: 227  VQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYR 286
               +    + +E  ++L   ++ + ++ ++  +   E ++  +   LEK    +K+K+  
Sbjct: 918  HDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLE 977

Query: 287  VQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEK---KLSNMYQEQCISLEEELA 343
             +    ED+  K+           +E+  +L ++  + K   KL N ++     LEE   
Sbjct: 978  EEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEE--- 1034

Query: 344  RIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKV-LRQKLKDL 402
            R+R EE  R+E+ K R    G    +           +I E++    ++K+ L +K ++L
Sbjct: 1035 RLRREEKQRQELEKTRRKLEGDSTDLSD---------QIAELQAQIAELKMQLAKKEEEL 1085

Query: 403  EQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454
            +  L  A V   A Q    L ++R+   +  ++Q +L++ ++     E + R
Sbjct: 1086 QAAL--ARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKR 1135



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 107/473 (22%), Positives = 194/473 (41%), Gaps = 71/473 (15%)

Query: 31   QKKMAECEAENEDL--LKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDM--QVCL 86
            ++  AE EA  ++   L      +EA E + +LE   +Q   E+ +L  +  D+   V  
Sbjct: 1463 ERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHE 1522

Query: 87   FQEREHVLRLYSENDRLRIRELEDKKK------------IQNLLALVGTDAGEVTYFCKE 134
             ++ +  L    E  + ++ ELED+ +            +Q + A    D        +E
Sbjct: 1523 LEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEE 1582

Query: 135  PPHKVTILQKTIQAVGECEQSESS-AFKADPKISKRRPSRERKESSEHYQRDIQTLILQV 193
               ++    + ++A  E E+ + S A  A  K+       E    S +  RD    I Q+
Sbjct: 1583 KKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRD--EAIKQL 1640

Query: 194  EALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYES 253
              LQAQ+ +     RE     ++D R   EEI  Q + N+ K+K +   +   QE L  +
Sbjct: 1641 RKLQAQMKD---CMRE-----LDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAA 1692

Query: 254  TKDFLQLRSE----------NQNKEKSWMLEKDNLMSKIKQYRVQCKKKE-------DKI 296
             +   Q + E          +  K    + EK  L ++I Q   + ++++       D++
Sbjct: 1693 ERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRL 1752

Query: 297  GKV--------LPVMHESHHAQ---------SEYIKSLKDKLVQ-EKKLSNMYQEQCISL 338
             K           +  E  HAQ             K LK KL + E  + + Y+    +L
Sbjct: 1753 KKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITAL 1812

Query: 339  EEELARIREE---EGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVL 395
            E ++A++ E+   E   R+    +  +  K+L+ +  + +  ERR     E +K      
Sbjct: 1813 EAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDD-ERR---NAEQYKDQADKA 1868

Query: 396  RQKLKDLEQMLYKATVNA-RANQD-LALLCEVRDSNRRAHKIQGELKNLKSKV 446
              +LK L++ L +A   A RAN     L  E+ D+   A  +  E+ +LK+K+
Sbjct: 1869 STRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 99/467 (21%), Positives = 203/467 (43%), Gaps = 65/467 (13%)

Query: 23   SKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAE-------- 74
            ++EL      K  E E    DL  ++E  +E C+     +  +QQ  +E+ E        
Sbjct: 899  AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESA 958

Query: 75   -----LQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVT 129
                 L+K  ++ ++   +E + +L    +N +L     ++KK +++ +A       E T
Sbjct: 959  RQKLQLEKVTTEAKLKKLEEEQIILE--DQNCKL----AKEKKLLEDRIA-------EFT 1005

Query: 130  YFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKE---SSEHYQRDI 186
                E   K   L K         +++  A   D +   RR  ++R+E   +    + D 
Sbjct: 1006 TNLTEEEEKSKSLAKL--------KNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057

Query: 187  QTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHT 246
              L  Q+  LQAQ+ E  K+   + E  ++     +EE   Q      KI+EL   +   
Sbjct: 1058 TDLSDQIAELQAQIAE-LKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISEL 1116

Query: 247  QELLYESTKDFLQLRSENQNKEKSWMLE------KDNLMSKIKQYRVQCKKKEDK--IGK 298
            QE L   ++   + ++E Q ++    LE      +D L S   Q  ++ K++++   + K
Sbjct: 1117 QEDL--ESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKK 1174

Query: 299  VLPVMHESHHAQ--------SEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEG 350
             L    ++H AQ        S+ ++ L ++L Q K++    ++   +LE E   +  E  
Sbjct: 1175 TLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVK 1234

Query: 351  MRREIFKDRTNKMGK---RLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLY 407
            +  +   D  +K  K   +LQ +  ++   ER R  E+    T ++V   +L ++  +L 
Sbjct: 1235 VLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVR-TELADKVTKLQV---ELDNVTGLLS 1290

Query: 408  KA-TVNARANQDL-ALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 452
            ++ + +++  +D  AL  +++D+     +   +  +L +K+  +E+E
Sbjct: 1291 QSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDE 1337



 Score = 29.3 bits (64), Expect = 7.7
 Identities = 29/126 (23%), Positives = 56/126 (44%), Gaps = 21/126 (16%)

Query: 332 QEQCISLEEELARIREE----EGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEG 387
           +E+ ++ EEEL ++RE+    E    E+   ++  M ++LQ+     E L+    L  E 
Sbjct: 844 EEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQ----EQLQAETELCAEA 899

Query: 388 FKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVF 447
            +   + L  K ++LE++ +             L   V +   R   +Q E K ++  + 
Sbjct: 900 EELRAR-LTAKKQELEEICHD------------LEARVEEEEERCQHLQAEKKKMQQNIQ 946

Query: 448 GLENEL 453
            LE +L
Sbjct: 947 ELEEQL 952


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score = 62.4 bits (150), Expect = 8e-10
 Identities = 90/440 (20%), Positives = 181/440 (41%), Gaps = 54/440 (12%)

Query: 14   EDRLAKLHPSKELL-EYYQKKMAECEAENEDL------LKKLELYKEACEG--------- 57
            ++ +AKL   K+ L E +Q+ + + +AE + +        KLE   +  EG         
Sbjct: 989  DETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLR 1048

Query: 58   ------QHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDK 111
                  + KLE DL+  +E   +++     +   L ++   +  L S+ +  +  E++ +
Sbjct: 1049 MDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQ 1108

Query: 112  KKIQNLLALV---GTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISK 168
            KKI+ L A +   G +         +   + + L + ++ + E  +    A  A  +++K
Sbjct: 1109 KKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNK 1168

Query: 169  RRPSRERKESSEHYQRDIQTLILQVEAL-----------QAQLGEQTKLSREQIEGLIED 217
            +R +  +K      +RD++   LQ EA+            A+LGEQ   + ++++  +E 
Sbjct: 1169 KREAEFQK-----LRRDLEEATLQHEAMVAALRKKHADSMAELGEQID-NLQRVKQKLEK 1222

Query: 218  RRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDN 277
             +  L+        N   I +   NL      L +   +      E Q        ++  
Sbjct: 1223 EKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRAR 1282

Query: 278  LMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCIS 337
            L ++  +Y  Q  +K+  + +    +  S  A ++ I+ LK +L +E K  N       S
Sbjct: 1283 LQTEAGEYSRQLDEKDALVSQ----LSRSKQASTQQIEELKHQLEEETKAKNALAHALQS 1338

Query: 338  LEEELARIR---EEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKV 394
               +   +R   EEE   +   +   +K    +     +YE    +R  E+E  K   K 
Sbjct: 1339 SRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK---KK 1395

Query: 395  LRQKLKDLEQMLYKATVNAR 414
            L Q+L++ E+  +   VNA+
Sbjct: 1396 LAQRLQEAEE--HVEAVNAK 1413



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 92/462 (19%), Positives = 191/462 (41%), Gaps = 65/462 (14%)

Query: 19   KLHPSKELLEYYQKKMAECEAENEDLLKKL-ELYKEACEGQ---HKLECDLQQREEEIAE 74
            +L   K + E    ++     EN++L +++ +L ++  EG    H+LE   +Q E+E  E
Sbjct: 1483 ELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCE 1542

Query: 75   LQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKE 134
            +Q AL + +  L  E   +LR+  E ++++                      EV     E
Sbjct: 1543 IQAALEEAEASLEHEEGKILRIQLELNQVK---------------------SEVDRKIAE 1581

Query: 135  PPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVE 194
               ++  L++    V E  QS       D +I  R  +   K+  E    D+  + +Q+ 
Sbjct: 1582 KDEEIDQLKRNHTRVVETMQS-----TLDAEIRSRNDALRVKKKME---GDLNEMEIQLN 1633

Query: 195  ALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYEST 254
                +L  ++  +    +G++++ ++HL++      R Q  +KE    +     LL    
Sbjct: 1634 HAN-RLAAESLRNYRNTQGILKETQLHLDDA----LRGQEDLKEQLAIVERRANLLQAEI 1688

Query: 255  KDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQ-------CKKKEDKI----GKVLPVM 303
            ++      + +   K    E  +   +++    Q        KK E+ +     +V  V+
Sbjct: 1689 EELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVI 1748

Query: 304  HESHHAQSEYIKSLKD------KLVQEKKLSNMYQEQCISLEEELA----RIREEEGMRR 353
             ES +A+ +  K++ D      +L +E+  S   +    +LE+ +     R+ E E +  
Sbjct: 1749 QESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAL 1808

Query: 354  EIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNA 413
            +  K +  K+  R++ +    E  ++R    V+G +       +++K+L     +   N 
Sbjct: 1809 KGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKH----ERRVKELTYQTEEDRKNV 1864

Query: 414  RANQDLA--LLCEVRDSNRRAHKIQGELKNLKSKVFGLENEL 453
               QDL   L  +V+   R+A + + +     SK   L++EL
Sbjct: 1865 LRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHEL 1906



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 98/453 (21%), Positives = 190/453 (41%), Gaps = 50/453 (11%)

Query: 17   LAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAE-L 75
            ++K+   + +    QKK+ E +A  E+L +++E  + +     K   DL +  EEI+E L
Sbjct: 1094 ISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERL 1153

Query: 76   QKA--LSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLL--ALVGTDAGEVTYF 131
            ++A   +  QV L ++RE      +E  +LR R+LE+       +  AL    A  +   
Sbjct: 1154 EEAGGATSAQVELNKKRE------AEFQKLR-RDLEEATLQHEAMVAALRKKHADSMAEL 1206

Query: 132  CKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRER------------KESS 179
             ++  +   + QK  +   E +            ISK + + E+            K   
Sbjct: 1207 GEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKE 1266

Query: 180  EHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKEL 239
            E  QR I  L  Q   LQ + GE ++   E+ + L+       +    Q +  +++++E 
Sbjct: 1267 EEQQRLINDLTAQRARLQTEAGEYSRQLDEK-DALVSQLSRSKQASTQQIEELKHQLEEE 1325

Query: 240  TKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKV 299
            TK  +     L  S  D   LR E   +E+    E    +SK      Q + K       
Sbjct: 1326 TKAKNALAHALQSSRHDCDLLR-EQYEEEQEGKAELQRALSKANSEVAQWRTK------- 1377

Query: 300  LPVMHESHHAQ-SEYIKSLKDKLVQEKKLSNMYQE----QCISLEEELARIREE-EGMRR 353
                +E+   Q +E ++  K KL Q  + +  + E    +C SLE+   R++ E E +  
Sbjct: 1378 ----YETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1433

Query: 354  EIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNA 413
            ++  +R+N     L    + ++ +      + E  + +++  +++ + L   L+K  V  
Sbjct: 1434 DV--ERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFK--VKN 1489

Query: 414  RANQDLALLCEVRDSNRRAHKIQGELKNLKSKV 446
               + L  L  +R  N+    +Q E+ +L  ++
Sbjct: 1490 VYEESLDQLETLRRENK---NLQQEISDLTEQI 1519



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 80/421 (19%), Positives = 181/421 (42%), Gaps = 44/421 (10%)

Query: 33   KMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREH 92
            K AE E E   + ++ +  K+      K E   ++ EE++  L K  +D+Q         
Sbjct: 844  KSAETEKEMATMKEEFQKTKDELA---KSEAKRKELEEKMVTLLKEKNDLQ--------- 891

Query: 93   VLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPH-KVTILQKTIQAVGE 151
             L++ SE D L   E   ++ I+N + L      EVT   +E       +  K  +   E
Sbjct: 892  -LQVQSEADSLADAEERCEQLIKNKIQL-EAKIKEVTERAEEEEEINAELTAKKRKLEDE 949

Query: 152  CEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQI 211
            C + +      +  ++K     + K ++E+  +++   +  ++   A+L ++ K  +E  
Sbjct: 950  CSELKKDIDDLELTLAK---VEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETH 1006

Query: 212  EGLIEDRRIHLEEIQV---QHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKE 268
            +  ++D +   +++ +      + + ++ +L  +L   ++L  +  +   +L  + +  +
Sbjct: 1007 QQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQ 1066

Query: 269  KSWM-LEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKL 327
            +S M +E D      +Q   + +KKE +I              S  I  ++D+   E +L
Sbjct: 1067 ESTMDMENDK-----QQLDEKLEKKEFEI--------------SNLISKIEDEQAVEIQL 1107

Query: 328  SNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEG 387
                +E    +EE    I  E   R +  K R++ + + L+ +++R E        +VE 
Sbjct: 1108 QKKIKELQARIEELGEEIEAERASRAKAEKQRSD-LSRELEEISERLEEAGGATSAQVEL 1166

Query: 388  FKTDIKVLRQKLKDLEQ--MLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSK 445
             K      ++  +DLE+  + ++A V A   +    + E+ +      +++ +L+  KS+
Sbjct: 1167 NKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSE 1226

Query: 446  V 446
            +
Sbjct: 1227 L 1227



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 70/340 (20%), Positives = 140/340 (41%), Gaps = 54/340 (15%)

Query: 152  CEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQI 211
            CEQ   +  + + KI +     ER E  E    ++     ++E       E ++L ++  
Sbjct: 908  CEQLIKNKIQLEAKIKE---VTERAEEEEEINAELTAKKRKLE------DECSELKKD-- 956

Query: 212  EGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSW 271
               I+D  + L +++ +    +NK+K LT+ +    E + + +K+   L+  +Q      
Sbjct: 957  ---IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDL 1013

Query: 272  MLEKD--NLMSKI------------------KQYRVQCKKKEDKIGKVLPVMHESHHAQS 311
              E+D  N+++K                   K+ R+  ++ + K+   L +  ES     
Sbjct: 1014 QAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDME 1073

Query: 312  EYIKSLKDKLVQEKK-------LSNMYQEQCISLE-----EELARIREEEGMRREIFKDR 359
               + L +KL  EKK       +S +  EQ + ++     +EL    EE G   E  +  
Sbjct: 1074 NDKQQLDEKL--EKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERAS 1131

Query: 360  TNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDL 419
              K  K+   +++  E +  R  LE  G  T  +V   K ++ E    +  +     Q  
Sbjct: 1132 RAKAEKQRSDLSRELEEISER--LEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHE 1189

Query: 420  ALLCEVRDSNRRAHKIQGE----LKNLKSKVFGLENELRL 455
            A++  +R  +  +    GE    L+ +K K+   ++EL++
Sbjct: 1190 AMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKM 1229


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 91/429 (21%), Positives = 193/429 (44%), Gaps = 46/429 (10%)

Query: 35   AECEAENEDLLKKLELYKEAC----EGQHKLECDLQQREEEIAELQKALSDMQVCLFQER 90
            A+ E + +DL   LE  K+        + KLE DL+  +E I +L+     ++  L ++ 
Sbjct: 1029 AKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKE 1088

Query: 91   EHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEV----TYFCKEPPHKVTILQKTI 146
              + +L ++ D  ++  L+ +KKI+ L A +     E+    T   K    + + L + +
Sbjct: 1089 FELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQR-SDLAREL 1147

Query: 147  QAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKL 206
            + + E  +  S A  A  +++K+R +  +K      +RD++   LQ EA  A L ++   
Sbjct: 1148 EEISERLEEASGATSAQIEMNKKREAEFQK-----MRRDLEEATLQHEATAATLRKKQAD 1202

Query: 207  S----REQIEGLIE-DRRIHLE--EIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQ 259
            S     EQI+ L    +++  E  E++++     + I+ L+K+  + +         F +
Sbjct: 1203 SVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSE 1262

Query: 260  LRSENQNKEK---SWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKS 316
            ++++++ + +      ++K  L ++  +   + ++KE  I +    + +S  A ++ ++ 
Sbjct: 1263 IKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQ----LTKSKQALTQQLEE 1318

Query: 317  LKDKLVQEKKLSNMYQEQCISLEEELARIR---EEEGMRREIFKDRTNKMGKRLQIMTKR 373
            LK ++ +E K  N       S   +   +R   EEE   +   +   +K    +     +
Sbjct: 1319 LKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTK 1378

Query: 374  YEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAH 433
            YE    +R  E+E  K   K L Q+L++ E+          AN   A L       +   
Sbjct: 1379 YETDAIQRTEELEEAK---KKLAQRLQEAEEN------TETANSKCASL------EKTKQ 1423

Query: 434  KIQGELKNL 442
            ++QGE+++L
Sbjct: 1424 RLQGEVEDL 1432



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 82/446 (18%), Positives = 187/446 (41%), Gaps = 60/446 (13%)

Query: 6    ESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDL 65
            E+  L   E+R   L  SK LLE   K++ E   E E++  +L   K             
Sbjct: 898  ETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKK------------- 944

Query: 66   QQREEEIAELQKALSDMQVCL--FQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGT 123
            +  E++ + L++ + D+++ L   ++ +H     +EN            K++NL   +  
Sbjct: 945  RNLEDKCSSLKRDIDDLELTLTKVEKEKHA----TEN------------KVKNLSEEMTA 988

Query: 124  DAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQ 183
                ++   KE        Q+T+  +   E   +   K + K+ ++    E     E   
Sbjct: 989  LEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQE--- 1045

Query: 184  RDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNL 243
               + L   +E  + +L    K+S+E I  L  D+    ++I+ + ++ + ++ +L   +
Sbjct: 1046 ---KKLRADLERAKRKLEGDLKMSQESIMDLENDK----QQIEEKLKKKEFELSQLQAKI 1098

Query: 244  HHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVM 303
               Q    +  K   +L++  +  E+    E   L +KI++ R    ++ ++I + L   
Sbjct: 1099 DDEQVHSLQFQKKIKELQARIEELEEEIEAE-HTLRAKIEKQRSDLARELEEISERL--- 1154

Query: 304  HESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKM 363
             E+  A S  I+  K +  + +K+    +E  +  E   A +R+++        D   ++
Sbjct: 1155 EEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQA-------DSVAEL 1207

Query: 364  GKRLQIMTKRYEALERRRI---LEVEGFKTDIKVLRQKLKDLEQMLYK-----ATVNARA 415
            G+++  + +  + LE+ +    +E++   ++I+ L +   ++E+         + + A+ 
Sbjct: 1208 GEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKD 1267

Query: 416  NQDLALLCEVRDSNRRAHKIQGELKN 441
             Q   L+ ++     R     GEL +
Sbjct: 1268 EQQTQLIHDLNMQKARLQTQNGELSH 1293



 Score = 52.4 bits (124), Expect = 9e-07
 Identities = 79/397 (19%), Positives = 166/397 (41%), Gaps = 38/397 (9%)

Query: 19   KLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKA 78
            KL  S+  LE  QK   E  + + +L K    Y+E  +    L  + +  +EEI++L + 
Sbjct: 1463 KLDESQAELEAAQK---ESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQ 1519

Query: 79   LSDMQVCLFQEREHVLRLYSEND---RLRIRELE-----DKKKIQNLLALVGTDAGEVTY 130
            +++    L QE E   +L  +     ++ + E+E     ++ KI  +   +     E+  
Sbjct: 1520 IAETGKNL-QEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDR 1578

Query: 131  FCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLI 190
               E   ++  L++  Q   E  QS       D +I  R  +   K+  E    D+  + 
Sbjct: 1579 KVIEKDEEIEQLKRNSQRAAEALQS-----VLDAEIRSRNDALRLKKKME---GDLNEME 1630

Query: 191  LQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELL 250
            +Q+     Q+ E  K  R  ++G ++D ++HL++      R+   +KE    +     LL
Sbjct: 1631 IQLGHSNRQMAETQKHLR-TVQGQLKDSQLHLDDA----LRSNEDLKEQLAIVERRNGLL 1685

Query: 251  YESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQ 310
             E  +   +++   +  E++  L +  L+    + ++   +    I     +  +    Q
Sbjct: 1686 LEELE---EMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQ 1742

Query: 311  SEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIM 370
            +E   S+++    E+K      +  +  EE    +++E+     +      +M K L+  
Sbjct: 1743 AEVENSIQESRNAEEKAKKAITDAAMMAEE----LKKEQDTSAHL-----ERMKKNLEQT 1793

Query: 371  TKRYE-ALERRRILEVEGFKTDIKVLRQKLKDLEQML 406
             K  +  L+    L ++G K  I+ L  ++++LE  L
Sbjct: 1794 VKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENEL 1830



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 98/477 (20%), Positives = 190/477 (39%), Gaps = 68/477 (14%)

Query: 30   YQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAE-LQKA--LSDMQVCL 86
            +QKK+ E +A  E+L +++E          K   DL +  EEI+E L++A   +  Q+ +
Sbjct: 1108 FQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEM 1167

Query: 87   FQEREHVLRLYSENDRLRIRELEDKKKIQNLLA--LVGTDAGEVTYFCKEPPHKVTILQK 144
             ++RE      +E  ++R R+LE+        A  L    A  V    ++  +   + QK
Sbjct: 1168 NKKRE------AEFQKMR-RDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQK 1220

Query: 145  TIQAVGECEQSESSAFKADPKISKRRPSRER------------KESSEHYQRDIQTLILQ 192
              +   E +            +SK + + ER            K   E   + I  L +Q
Sbjct: 1221 LEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQ 1280

Query: 193  VEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYE 252
               LQ Q GE +    E+ E LI       + +  Q +  + +++E TK  +     L  
Sbjct: 1281 KARLQTQNGELSHRVEEK-ESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQS 1339

Query: 253  STKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSE 312
            S  D   LR E   +E+    E    +SK      Q + K +     +    E   A+  
Sbjct: 1340 SRHDCDLLR-EQYEEEQEAKAELQRALSKANSEVAQWRTKYET--DAIQRTEELEEAK-- 1394

Query: 313  YIKSLKDKLVQEKKLSNMYQEQCISLEEELARIR-EEEGMRREI---------------- 355
              K L  +L + ++ +     +C SLE+   R++ E E + R++                
Sbjct: 1395 --KKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRN 1452

Query: 356  -------FKDRTNKMGKRLQIMTKRYEALE----------RRRILEVEGFKTDIKVLRQK 398
                   +K + ++    L+   K   +L              + ++E  + + K L+++
Sbjct: 1453 FDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEE 1512

Query: 399  LKDLEQMLYKATVNARANQDLALLCEVRDSNRRA--HKIQGELKNLKSKVFGLENEL 453
            + DL + + +   N +  +    L E   S+ +    +++G L++ +SK+  ++ EL
Sbjct: 1513 ISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLEL 1569



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 68/346 (19%), Positives = 149/346 (43%), Gaps = 61/346 (17%)

Query: 161  KADPKISKRRPSRERKESSEHYQRDIQTLIL---QVEALQAQLGEQTKLSRE-------- 209
            K D ++  +  +    ++ E  +  I++ IL   +V+ L  +L E+ +++ E        
Sbjct: 888  KNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNL 947

Query: 210  -----QIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSEN 264
                  ++  I+D  + L +++ +    +NK+K L++ +   +E + + TK+   L+  +
Sbjct: 948  EDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAH 1007

Query: 265  QNKEKSWMLEKDNL--------------------MSKIKQYRVQCKKKEDKIGKVLPVMH 304
            Q       +E+D +                    + + K+ R   ++ + K+   L +  
Sbjct: 1008 QQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQ 1067

Query: 305  ES----HHAQSEYIKSLKDKLVQEKKL-SNMYQEQCISLE------EELARIRE------ 347
            ES     + + +  + LK K  +  +L + +  EQ  SL+      E  ARI E      
Sbjct: 1068 ESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIE 1127

Query: 348  -EEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQML 406
             E  +R +I K R++ + + L+ +++R E        ++E  K      ++  +DLE+  
Sbjct: 1128 AEHTLRAKIEKQRSD-LARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEAT 1186

Query: 407  YK-----ATVNARANQDLALLCEVRDSNRRA-HKIQGELKNLKSKV 446
             +     AT+  +    +A L E  D+ +R   K++ E   LK ++
Sbjct: 1187 LQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEI 1232



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 59/294 (20%), Positives = 118/294 (40%), Gaps = 56/294 (19%)

Query: 160  FKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRR 219
            FK  P +      +E     E ++R  + L  + EA + +L        E++  L++++ 
Sbjct: 838  FKIKPLLKSAEAEKEMATMKEDFERTKEELA-RSEARRKEL-------EEKMVSLLQEKN 889

Query: 220  IHLEEIQVQHQ-RNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNL 278
                ++QVQ +  N    +E  + L  ++ LL    K+  +   E +      + +K NL
Sbjct: 890  DL--QLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNL 947

Query: 279  MSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISL 338
              K        K+  D +   L  + +  HA    +K+L +++               +L
Sbjct: 948  EDKCSSL----KRDIDDLELTLTKVEKEKHATENKVKNLSEEMT--------------AL 989

Query: 339  EEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQK 398
            EE ++++ +E+   +E  +   +     LQ+   +   L           K + K L Q+
Sbjct: 990  EENISKLTKEKKSLQEAHQQTLDD----LQVEEDKVNGL----------IKINAK-LEQQ 1034

Query: 399  LKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 452
              DLE  L          Q+  L  ++  + R   K++G+LK  +  +  LEN+
Sbjct: 1035 TDDLEGSL---------EQEKKLRADLERAKR---KLEGDLKMSQESIMDLEND 1076


>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
           [Homo sapiens]
          Length = 1354

 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 94/504 (18%), Positives = 208/504 (41%), Gaps = 68/504 (13%)

Query: 14  EDRLAKLHPSKELLEY----YQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQRE 69
           E  ++++   K LL++    YQ+K  +   +  ++  ++   K+  E   K+  + Q   
Sbjct: 478 ESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLAN 537

Query: 70  EEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRI---------RELEDKKKI------ 114
           E++++LQK L +    L  E +  +RL   +  +           REL+++ +I      
Sbjct: 538 EKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKS 597

Query: 115 ---------QNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGE-CEQSESSAFKADP 164
                    Q +L     D G  +    +   ++T LQ+ ++ +    E+ E    +A  
Sbjct: 598 QTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQD 657

Query: 165 KISKRRPSRERKESSEHYQ-RDIQTLILQV-------------------EALQAQLGEQT 204
            ++     +   E   +Y+ + +Q  + Q                    EA    + E  
Sbjct: 658 MLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEME 717

Query: 205 KLSREQIEGL--IEDRRIHLEE----IQVQHQRNQNKIKELTKNLHHTQELLYESTKDFL 258
           K  +E+ E     E+R + +E+    + V  +++Q K++ LT N    ++ +   T   L
Sbjct: 718 KKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLT---L 774

Query: 259 QLRSEN------QNKEKSWMLEKDNLMSKIKQYRVQCK---KKEDKIGKVLPVMHESHHA 309
           QL  E+      QN+ K+   E DNL    KQ + +     + +  +   L  + + +  
Sbjct: 775 QLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRG 834

Query: 310 QSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQI 369
               ++ L+D+L  E+  S +Y+ Q   L+EE+     E   + +  ++    +  +L +
Sbjct: 835 NEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDL 894

Query: 370 MTKRYEALE-RRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDS 428
              + E+ +  R +LE + F+   +  +   ++ +++  K    +R  +  ++L +  + 
Sbjct: 895 AETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEI 954

Query: 429 NRRAHKIQGELKNLKSKVFGLENE 452
            RR ++   E      + + LE E
Sbjct: 955 LRRENEELTEKMKKAEEEYKLEKE 978



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 57/248 (22%), Positives = 101/248 (40%), Gaps = 34/248 (13%)

Query: 229 HQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQ 288
           ++ + N  K L ++L  T   L E   + +QL+ E + K ++  ++ D +M ++ +   Q
Sbjct: 414 NRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQ 473

Query: 289 CKKKEDKIGKVLPVMHESHHAQSEY-----------------IKSLKDKLVQEKKLSNMY 331
            +  E  + ++        H  +EY                 + +LKD+L   KK+S   
Sbjct: 474 RRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNS 533

Query: 332 Q---EQCISLEEELAR----IREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILE 384
           Q   E+   L+++L      +R E      + K  T       Q+ +   E  ER RILE
Sbjct: 534 QLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILE 593

Query: 385 VEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKS 444
               +TD        KD  Q+  +A + A           + D   R   +Q E+K+LK 
Sbjct: 594 NSKSQTD--------KDYYQL--QAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKH 643

Query: 445 KVFGLENE 452
            +  +E E
Sbjct: 644 NLEKVEGE 651


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 104/477 (21%), Positives = 199/477 (41%), Gaps = 68/477 (14%)

Query: 14   EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA 73
            E+R  +L  S+E  E  Q+++   + E  +   K E  +E  E + K E + ++RE+E+A
Sbjct: 627  EERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELA 686

Query: 74   ELQKALSDMQVCLFQEREHV--------LRLYSENDR------LRIRELEDKKKIQNLLA 119
            E ++          Q RE +         +L SE D        R R+ E +++ Q    
Sbjct: 687  EEEQE---------QARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEE 737

Query: 120  LVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESS 179
                   E+ +  +E  H+    ++  +      Q+E  + +   ++S R P RE++E  
Sbjct: 738  KRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRER- 796

Query: 180  EHYQRDIQTLILQVEALQAQLGEQTKL-SREQIEGLIEDRRIHLEEIQVQHQRNQNKIKE 238
                        Q+ A + Q  EQ  L   E+ E     RR   +E+Q   +  Q + +E
Sbjct: 797  ------------QLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRE 844

Query: 239  LTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGK 298
              + L   ++ L E   D  + RS+ Q +++ W  + +    + +         ++++ K
Sbjct: 845  RAQQLQEEEDGLQE---DQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRK 901

Query: 299  VLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKD 358
               ++ E         +  + +  QE++    Y+E+    +EE   +REE   RR   ++
Sbjct: 902  EQQLLQEEEEELQREEREKRRRQEQERQ----YREEEQLQQEEEQLLREEREKRRRQERE 957

Query: 359  RTNKMGKRLQIMTKRY--EALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNAR-- 414
            R  +  K+LQ   ++   E  E+RR  E E    + + L+Q   + EQ+L +     R  
Sbjct: 958  RQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQ---EEEQLLREEREKRRRQ 1014

Query: 415  ------------ANQDLALLCEVRDSNR-----RAHKIQGELKNLKSKVFGLENELR 454
                          ++  LL E R+  R     R ++ + EL+  + ++ G E E R
Sbjct: 1015 EWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETR 1071



 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 104/476 (21%), Positives = 199/476 (41%), Gaps = 88/476 (18%)

Query: 10   LPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQRE 69
            L   E++L    P K   +  +KK  E   E E   ++ +L +E  E + + E + Q R+
Sbjct: 966  LQQKEEQLLGEEPEKRRRQEREKKYRE---EEELQQEEEQLLREEREKRRRQEWERQYRK 1022

Query: 70   EEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIREL---EDKKKIQNLLALVGTDAG 126
            ++  ELQ           QE E +LR   E  RL+ RE    E+++  Q    L+G +  
Sbjct: 1023 KD--ELQ-----------QEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEE-- 1067

Query: 127  EVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRER--KESSEHYQR 184
                       +   L++  +   E +Q E    + +P+  +RR  RER  +E  E  Q 
Sbjct: 1068 -------RETRRRQELERQYRKEEELQQEEEQLLREEPE-KRRRQERERQCREEEELQQE 1119

Query: 185  DIQTLILQVE-----ALQAQLGEQTKLSREQIEGL----------------IEDRRIHLE 223
            + Q L  + E      L+ Q  E+ ++ +E+ + L                 E+  +  E
Sbjct: 1120 EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQE 1179

Query: 224  EIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIK 283
            E Q+  +  + + +E  +     +EL  +  K   + R E+Q  +  W  E +   + ++
Sbjct: 1180 EEQLLREEQEKRRQERERQYREEEELQRQKRKQ--RYRDEDQRSDLKWQWEPEK-ENAVR 1236

Query: 284  QYRVQCKKKEDKIGKVLPVM----HESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLE 339
              +V CK +E++  + L        +S       +   +++  ++++     +++    E
Sbjct: 1237 DNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEE 1296

Query: 340  EELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKL 399
            E+L R  ++E  RR    DR ++  K+L     R E  E+RR  E +          +K 
Sbjct: 1297 EQLEREEQKEAKRR----DRKSQEEKQL----LREEREEKRRRQETD----------RKF 1338

Query: 400  KDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRL 455
            ++ EQ+L       +  ++  L  + RD   R  +++ + +  K     LE E RL
Sbjct: 1339 REEEQLL-------QEREEQPLRRQERDRKFREEELRHQEQGRKF----LEEEQRL 1383



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 81/379 (21%), Positives = 160/379 (42%), Gaps = 38/379 (10%)

Query: 105 IRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQ-SESSAFKAD 163
           +R   D K +  +L L+  D+     F +       + Q    A+G+     E    + D
Sbjct: 45  LRRPHDPKTVDLILELLDLDSNGRVDFNEFLLFIFKVAQACYYALGQATGLDEEKRARCD 104

Query: 164 PKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIE------- 216
            K S  +  R+ ++      RD Q   L+ E  Q +  ++ +  RE  EG  +       
Sbjct: 105 GKESLLQDRRQEEDQRRFEPRDRQ---LEEEPGQRRRQKRQEQERELAEGEEQSEKQERL 161

Query: 217 ---DRRIHLEEIQVQHQRNQNKIKELTKNL-------HHTQELLYEST---KDFLQLRSE 263
              DR+   EE+  Q Q  Q + +   +         H T+E   E     ++ L+LR +
Sbjct: 162 EQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRK 221

Query: 264 NQNKEKSWMLEKDNLM---SKIKQYRVQ---CKKKEDKIGKVLPVMHESHHAQSEYIKSL 317
            + +++    E+ + +    + K++R +    +K+E+K+ +  P        + E ++ L
Sbjct: 222 GREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKL 281

Query: 318 KDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEAL 377
           + + ++ ++     Q+Q +  E++L R +EEE  RRE  ++R  +  +R Q   +R + L
Sbjct: 282 ERQELRRERQEEEQQQQRLRREQQLRRKQEEE--RREQQEERREQQERREQQEERREQQL 339

Query: 378 ERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSN--RRAHKI 435
            R    E E  +       Q+ +  EQ L +     R  Q L    ++R     RR  ++
Sbjct: 340 RR----EQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQL 395

Query: 436 QGELKNLKSKVFGLENELR 454
           + E +  + +    E +LR
Sbjct: 396 RREQQLRREQQLRREQQLR 414



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 95/440 (21%), Positives = 184/440 (41%), Gaps = 53/440 (12%)

Query: 10  LPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKL------ELYKEACEGQHKLEC 63
           L   E++L KL   +   E  +++  +     E  L++       E  +E  E Q + E 
Sbjct: 271 LQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQ 330

Query: 64  DLQQREEEIAELQKALSDMQVCLFQE---REHVLRLYSENDRL--RIRELEDKKKIQNL- 117
             ++RE+++   Q+   + Q+   QE   RE  LR   E +R   ++R  +  ++ Q L 
Sbjct: 331 QEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLR 390

Query: 118 ----LALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSR 173
               L        E     ++   +   L++  Q   E E+ E    K + +  ++R  R
Sbjct: 391 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEE-ERHEQKHEQERREQRLKR 449

Query: 174 ERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQ--IEGLIEDRRIHLEEIQVQHQR 231
           E++E  +  +R+ +T   + E  + QL    +  R +  ++   E+RR   E  + Q +R
Sbjct: 450 EQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRR 509

Query: 232 NQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNK-------EKSWMLEKDNLMSKIK- 283
            Q + +E        +E L +  +   QLR E + +       E+   LE++    ++K 
Sbjct: 510 EQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKR 569

Query: 284 ---QYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEE 340
              + R Q  K+E++              + E  + L+ +L +E ++  + QE+    E+
Sbjct: 570 EQEERRDQLLKREEE--------RRQQRLKREQEERLEQRLKRE-EVERLEQEE--RREQ 618

Query: 341 ELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLK 400
            L R   EE  R+++ K    +  ++ Q+  ++ E  E+R   E E             +
Sbjct: 619 RLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEE------------E 666

Query: 401 DLEQMLYKATVNARANQDLA 420
            LEQ L +     R  Q+LA
Sbjct: 667 RLEQRLKREHEEERREQELA 686



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 87/440 (19%), Positives = 187/440 (42%), Gaps = 60/440 (13%)

Query: 40   ENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSE 99
            E E  +++ E  ++  E + +L    Q+R  +  E ++ L + +      +E   +   E
Sbjct: 1434 EEEQQVRRQERERKFLEEEQQLR---QERHRKFREEEQLLQEREEQQLHRQERDRKFLEE 1490

Query: 100  NDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSA 159
              +LR +E + K + Q L +             +EP  K    ++ +      +Q +   
Sbjct: 1491 EQQLRRQERDRKFREQELRS-------------QEPERKFLEEEQQLHR----QQRQRKF 1533

Query: 160  FKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRR 219
             + + ++ ++   ++R++  +   R+ + L         Q  E+ +LSR++      DR+
Sbjct: 1534 LQEEQQLRRQERGQQRRQDRDRKFREEEQL--------RQEREEQQLSRQE-----RDRK 1580

Query: 220  IHLEEIQVQHQRNQNKIKELTKNLHHT---QELLYESTKDF------LQLRSENQ----N 266
              LEE +V+ Q  + K  E  + L      Q+L  E  + F      LQ R E Q     
Sbjct: 1581 FRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQE 1640

Query: 267  KEKSWMLEKDNL--MSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQ- 323
            +++ ++ E+  L    + +Q R    +K  +  ++L    E    + E  +  +++  Q 
Sbjct: 1641 RDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQL 1700

Query: 324  ---EKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALER- 379
               E++   + +EQ +  +E   + REEE +R+E  +++  +  +  +I+ +     ER 
Sbjct: 1701 RRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPERE 1760

Query: 380  ----RRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKI 435
                RR      F+ + + LRQ+ +  EQ L     + +  ++  L  E  +   R  + 
Sbjct: 1761 EQQLRRQERDRKFREE-EQLRQERE--EQQLRSQESDRKFREEEQLRQEREEQQLRPQQR 1817

Query: 436  QGELKNLKSKVFGLENELRL 455
             G+ +  + ++   E E RL
Sbjct: 1818 DGKYRWEEEQLQLEEQEQRL 1837



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 101/446 (22%), Positives = 187/446 (41%), Gaps = 52/446 (11%)

Query: 14   EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA 73
            + R  +  P +E  E  +++  E E E + L ++ +L +     Q      LQ+ E+ + 
Sbjct: 804  QQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQ------LQEEEDGLQ 857

Query: 74   ELQKALSDMQVCLFQEREHVLRLYSENDRLRIRE-LEDKKKIQNLLA----LVGTDAGEV 128
            E Q+     +    Q R+   R   E +R R R  L  K  +Q  L     L+  +  E+
Sbjct: 858  EDQERRRSQE----QRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEEL 913

Query: 129  TYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQT 188
                +E   +    Q+      E  Q E      + +  +RR  RER+     Y++D + 
Sbjct: 914  QREEREKRRRQE--QERQYREEEQLQQEEEQLLREEREKRRRQERERQ-----YRKD-KK 965

Query: 189  LILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQE 248
            L  + E L   LGE+ +  R Q     E  + + EE ++Q +  Q   +E  K      E
Sbjct: 966  LQQKEEQL---LGEEPEKRRRQ-----EREKKYREEEELQQEEEQLLREEREKRRRQEWE 1017

Query: 249  LLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQ---CKKKEDKIGKVLPVMH- 304
              Y   KD LQ   E   +E+    EK  L  + +QYR +    +++E  +G+       
Sbjct: 1018 RQYRK-KDELQQEEEQLLREER---EKRRLQERERQYREEEELQQEEEQLLGEERETRRR 1073

Query: 305  ---ESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTN 361
               E  + + E ++  +++L++E+      QE+     EE    +EEE + RE   +R  
Sbjct: 1074 QELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLRE---EREK 1130

Query: 362  KMGKRLQIMTKRYEAL--ERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDL 419
            +  + L+   +  E +  E  ++L  E  K   + L ++ ++ E++  +     R  Q+ 
Sbjct: 1131 RRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQE- 1189

Query: 420  ALLCEVRDSNRRAHKIQGELKNLKSK 445
                + R    R ++ + EL+  K K
Sbjct: 1190 ----KRRQERERQYREEEELQRQKRK 1211



 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 70/341 (20%), Positives = 141/341 (41%), Gaps = 63/341 (18%)

Query: 14   EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA 73
            E  L    P ++ LE  Q+   + + + + L ++ +L ++    Q + + D + REEE  
Sbjct: 1505 EQELRSQEPERKFLEEEQQLHRQ-QRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEE-- 1561

Query: 74   ELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCK 133
            +L++   + Q+   QER+   RL  +    ++R  E ++K       +    G+     +
Sbjct: 1562 QLRQEREEQQLSR-QERDRKFRLEEQ----KVRRQEQERKFMEDEQQLRRQEGQ-QQLRQ 1615

Query: 134  EPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQV 193
            E   K    ++  Q + E E+ +    + D K  +  P   R+E  +  + D      + 
Sbjct: 1616 ERDRK---FREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREE 1672

Query: 194  EALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYES 253
            E L  Q GE+ +L R++      DR+   EE Q++ Q  + K  +  + L   +  L   
Sbjct: 1673 EQL-LQEGEEQQLRRQE-----RDRKFREEEQQLRRQERERKFLQEEQQLRRQE--LERK 1724

Query: 254  TKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEY 313
             ++  QLR E + ++          + + ++YR                           
Sbjct: 1725 FREEEQLRQETEQEQ----------LRRQERYR--------------------------- 1747

Query: 314  IKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRRE 354
                  K+++E++L    +EQ +  +E   + REEE +R+E
Sbjct: 1748 ------KILEEEQLRPEREEQQLRRQERDRKFREEEQLRQE 1782



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 86/434 (19%), Positives = 182/434 (41%), Gaps = 49/434 (11%)

Query: 24  KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQ 83
           +E  E   ++  E E   + L ++ +L +E    Q + E  L+ RE+++   Q+   + Q
Sbjct: 357 EERREQQLRREQEEERREQQLRREQQLRREQ---QLRREQQLR-REQQLRREQQLRREQQ 412

Query: 84  VCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQ 143
           +   Q+     +L  E +  R  +  ++++ +  L     +  +  +  +E   +    +
Sbjct: 413 LRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRD--WLKREEETERHEQE 470

Query: 144 KTIQAVGECEQSESSAFKADPKISKRRPSRERKESS---EHYQRDIQTLILQVEA--LQA 198
           +  Q +   ++ E        +  +RR  +ER+E     E  +R  Q L  Q E   LQ 
Sbjct: 471 RRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQ 530

Query: 199 QLGEQTKLSREQIEGLIEDRRIHL----EEIQVQHQRNQNKIKELTKNLHHTQELLYEST 254
           +L  + +L REQ     E+RR  L    EE +++ +R + ++K              E  
Sbjct: 531 RLRSEQQLRREQ-----EERREQLLKREEEKRLEQERREQRLKREQ-----------EER 574

Query: 255 KDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYI 314
           +D L  R E + +++    +++ L  ++K+  V+  ++E++  + L         + + +
Sbjct: 575 RDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLL 634

Query: 315 KSLKDKLVQEKKLSNMYQEQCIS----------LEEELARIREEEGMRREIFKDRTNKMG 364
           KS + +  ++++L    QE+             LE+ L R  EEE   +E+ ++   +  
Sbjct: 635 KSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR 694

Query: 365 KRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCE 424
           +R++    +++       LE E      KV  +  K   Q   +     R  ++  L  +
Sbjct: 695 ERIKSRIPKWQWQ-----LESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQ 749

Query: 425 VRDSNRRAHKIQGE 438
                 RAH+ Q E
Sbjct: 750 ---EEERAHRQQQE 760



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 100/460 (21%), Positives = 193/460 (41%), Gaps = 63/460 (13%)

Query: 22   PSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD---------LQQREEEI 72
            P +E LE  ++K A+         K+L L +E  E + + E D         LQ+REE+ 
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQL-LREEREEKRRRQETDRKFREEEQLLQEREEQP 1352

Query: 73   AELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDK--KKIQNLLALVGTDAGEVTY 130
               Q+     +    + +E   +   E  RLR +E E K  K+ Q L             
Sbjct: 1353 LRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLR------------ 1400

Query: 131  FCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISK-----RRPSRERKESSEHYQ-R 184
             C+E   +   L++        E+ + S  + D K  +     RR  RERK   E  Q R
Sbjct: 1401 -CQEREQQ---LRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLR 1456

Query: 185  DIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLH 244
              +    + E    Q  E+ +L R++      DR+   EE Q++ Q    K +E      
Sbjct: 1457 QERHRKFREEEQLLQEREEQQLHRQE-----RDRKFLEEEQQLRRQERDRKFRE------ 1505

Query: 245  HTQEL-LYESTKDFLQLRSE--NQNKEKSWMLEKDNLMSKIKQYRVQCKK--KEDKIGKV 299
              QEL   E  + FL+   +   Q +++ ++ E+  L    +Q R Q ++  ++ K  + 
Sbjct: 1506 --QELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLR---RQERGQQRRQDRDRKFREE 1560

Query: 300  LPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDR 359
              +  E    Q    +  +   ++E+K+    QE+    +E+  ++R +EG ++++ ++R
Sbjct: 1561 EQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQ--QLRRQEG-QQQLRQER 1617

Query: 360  TNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLK-----DLEQMLYKATVNAR 414
              K  +  Q++ +R E    R+  + +  + + ++ RQ+ +     D ++   +     +
Sbjct: 1618 DRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQ 1677

Query: 415  ANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454
              ++  L  + RD   R  + Q   +  + K    E +LR
Sbjct: 1678 EGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLR 1717



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 84/422 (19%), Positives = 185/422 (43%), Gaps = 43/422 (10%)

Query: 38  EAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLY 97
           E  +E+ L++ EL +   +G+ + +   ++R++ + + ++         +++RE VLR  
Sbjct: 203 EFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKE------WRKRETVLR-- 254

Query: 98  SENDRLRIRELEDKKKIQNLLA-LVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSE 156
            E ++L+  E + ++++Q     L   +  E+    +E   +   L++  Q   + E+  
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER 314

Query: 157 SSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIE 216
               +   +  +RR  +E +   +  +   +    Q+   Q +   + +L REQ     E
Sbjct: 315 REQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ----EE 370

Query: 217 DRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKD 276
           +RR      + Q +R Q   +E  + L   Q+L  E      QLR E Q + +  +  + 
Sbjct: 371 ERREQQLRREQQLRREQQLRRE--QQLRREQQLRREQ-----QLRREQQLRREQQLRREQ 423

Query: 277 NLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCI 336
            L  + ++ R + K ++++  + L    E            +D L +E++     QE+  
Sbjct: 424 QLRREQEEERHEQKHEQERREQRLKREQEER----------RDWLKREEETERHEQER-- 471

Query: 337 SLEEELARIREEEGMRREI---FKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIK 393
             +++L R +EEE   R +    ++R  +  +R Q + +  E    +R+   E    + +
Sbjct: 472 -RKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQE----EEE 526

Query: 394 VLRQKLKDLEQMLYKATVNARANQDLALLCEVR-DSNRRAHKIQGELKNLKSKVFGLENE 452
            L+Q+L+  +Q+  +     R  Q L    E R +  RR  +++ E +  + ++   E E
Sbjct: 527 RLQQRLRSEQQL--RREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEE 584

Query: 453 LR 454
            R
Sbjct: 585 RR 586



 Score = 42.4 bits (98), Expect = 9e-04
 Identities = 61/341 (17%), Positives = 144/341 (42%), Gaps = 43/341 (12%)

Query: 31   QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQER 90
            ++K+   E E + +  + +L ++  EGQ +L    Q+R+ +  E ++ L + +      +
Sbjct: 1585 EQKVRRQEQERKFMEDEQQLRRQ--EGQQQLR---QERDRKFREDEQLLQEREEQQLHRQ 1639

Query: 91   EHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVG 150
            E   +   E  +LR +E E + +                        +    ++  Q + 
Sbjct: 1640 ERDRKFLEEEPQLRRQEREQQLRHD----------------------RDRKFREEEQLLQ 1677

Query: 151  ECEQSESSAFKADPKISK-----RRPSRERKESSEHYQ---RDIQTLILQVEALQAQLGE 202
            E E+ +    + D K  +     RR  RERK   E  Q   ++++    + E L+ +  +
Sbjct: 1678 EGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQ 1737

Query: 203  QTKLSREQIEGLIEDRRIH--LEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQL 260
            +    +E+   ++E+ ++    EE Q++ Q    K +E  +     +E    S +   + 
Sbjct: 1738 EQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKF 1797

Query: 261  RSENQ----NKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMH--ESHHAQSEYI 314
            R E Q     +E+    ++ +   + ++ ++Q +++E ++ +     +  E   A  E  
Sbjct: 1798 REEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKS 1857

Query: 315  KSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREI 355
            +  + +L QE++     + +    EE + R ++EE   R++
Sbjct: 1858 RREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQV 1898



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 73/378 (19%), Positives = 154/378 (40%), Gaps = 39/378 (10%)

Query: 24  KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQ 83
           +E  E   K+  E E   + L  + +L +E  E + +L   L++ EE+  E ++    ++
Sbjct: 512 EERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL---LKREEEKRLEQERREQRLK 568

Query: 84  VCLFQEREHVLRLYSENDRLRIRE-----LEDKKKIQNLLALVGTDAGEVTYFCKEPPHK 138
               + R+ +L+   E  + R++      LE + K + +  L   +  E     +EP   
Sbjct: 569 REQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEE- 627

Query: 139 VTILQKTIQAVGECEQSESSAFKADPKISKRRPSR-ERKESSEHYQRDIQTLILQVEALQ 197
               ++  Q +   EQ E    +   +  +RR  R +R+E  E  ++ ++    +    Q
Sbjct: 628 ----ERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQ 683

Query: 198 AQLGEQTKLSREQIEGLIEDRRIHLEE----------IQVQHQRNQNKIKELTKNLHHTQ 247
               E+ + +RE+I+  I   +  LE            + + Q  Q + +E  +     +
Sbjct: 684 ELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRE 743

Query: 248 ELLY--ESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHE 305
             L   E  +   Q + E Q ++ +W  + +    + +Q R+  +          P + E
Sbjct: 744 SELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQ-RLSAR----------PPLRE 792

Query: 306 SHHAQ--SEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKM 363
               Q  +E  +  + + + E++     + Q    E+EL  + EEE ++R     +  + 
Sbjct: 793 QRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEE 852

Query: 364 GKRLQIMTKRYEALERRR 381
              LQ   +R  + E+RR
Sbjct: 853 EDGLQEDQERRRSQEQRR 870


>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
          Length = 2028

 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 104/453 (22%), Positives = 194/453 (42%), Gaps = 67/453 (14%)

Query: 33   KMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCL--FQER 90
            K+++ E E   L + LE  KE  E   KLE +LQ+ +EE   L + ++ ++      +  
Sbjct: 605  KLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEAL 664

Query: 91   EHVLR-LYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAV 149
            EH  + L  EN  LR + L+  + +   L  +  D  ++     E    V  ++ T   +
Sbjct: 665  EHESQGLQLENRTLR-KSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKL 723

Query: 150  GECEQSES-------------SAFKADPKISKRRPSRERKESSEH--YQRDIQTLILQVE 194
             + E+                   KA  K S+R     +  S+E+   Q+ +++   + +
Sbjct: 724  AQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQ 783

Query: 195  ALQAQLG-------------EQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTK 241
             L+++LG             E  +L+  Q+EG  +DR+  LE+   Q ++++  +++  K
Sbjct: 784  TLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKA-LEQEVAQLEKDKKLLEKEAK 842

Query: 242  NLHHTQEL----LYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIG 297
             L    EL    L +ST     +  E++  +K     +D    K+K    + +K    + 
Sbjct: 843  RLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRD-AAGKLK----ELEKDNRDLT 897

Query: 298  KVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFK 357
            K + V     HA++  + +L++ LV EK  S     +   L +EL    E+ G+ RE+  
Sbjct: 898  KQVTV-----HART--LTTLREDLVLEKLKSQQLSSELDKLSQEL----EKVGLNRELLL 946

Query: 358  DRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLE-QMLYKATVNARAN 416
               +           +Y+ LE R        KT + +  +K+  LE QM  KA++N +  
Sbjct: 947  QEDDSGS------DTKYKILEGR---NESALKTTLAMKEEKIVLLEAQMEEKASLNRQLE 997

Query: 417  QDLALL---CE-VRDSNRRAHKIQGELKNLKSK 445
             +L +L   CE +R +      +Q   K+   K
Sbjct: 998  SELQMLKKECETLRQNQGEGQHLQNSFKHPAGK 1030



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 110/473 (23%), Positives = 199/473 (42%), Gaps = 82/473 (17%)

Query: 12  SPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEE 71
           S +  +  L  +  +LE    K  E E EN  L KK+E  +   E + +   DL+   EE
Sbjct: 474 SLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEE 533

Query: 72  -IAELQKALSDMQVC----------LFQEREHVLR-LYSENDRLRI---RELEDKKKIQN 116
            I E ++  SDM+            L QE++H+ R ++S  +R ++     ++D +K   
Sbjct: 534 LIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENK 593

Query: 117 LLALVGTDA-GEVTYF-------------CKEPPHKVTILQKTIQAVGECEQSESSAFKA 162
            L    T+A G+++                KE   +   L++ +Q +    Q E+   + 
Sbjct: 594 ALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRL----QEENG--RL 647

Query: 163 DPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHL 222
             K++    + E+ E+ EH  + +Q   L+   L+  L     +S  Q+EGL  D +   
Sbjct: 648 ARKVTSLETATEKVEALEHESQGLQ---LENRTLRKSLDTLQNVSL-QLEGLERDNK--- 700

Query: 223 EEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKI 282
                Q      +++ L + +  T      STK   Q+  ENQ  E+    EK+ L   +
Sbjct: 701 -----QLDAENLELRRLVETMRFT------STK-LAQMERENQQLER----EKEELRKNV 744

Query: 283 KQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEEL 342
              +   KK E      L + ++S         S ++  +Q+   S+ ++ Q  +LE EL
Sbjct: 745 DLLKALGKKSER-----LELSYQS--------VSAENLRLQQSLESSSHKTQ--TLESEL 789

Query: 343 ARIR-EEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKD 401
             +  E + +RR++  +       +L+   K  +ALE+    EV   + D K+L ++ K 
Sbjct: 790 GELEAERQALRRDL--EALRLANAQLEGAEKDRKALEQ----EVAQLEKDKKLLEKEAKR 843

Query: 402 LEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454
           L Q +     +A  +   A L  V   +R   K     ++   K+  LE + R
Sbjct: 844 LWQQV--ELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNR 894



 Score = 55.8 bits (133), Expect = 8e-08
 Identities = 87/408 (21%), Positives = 168/408 (41%), Gaps = 50/408 (12%)

Query: 19  KLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKA 78
           KLH     +++Y+ +M E   +N  L++   + +E           + + E+E  +L+  
Sbjct: 338 KLHD----VDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSK 393

Query: 79  LSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHK 138
           L D+++    +++ +  L  EN  L I + +   +  +L         E+    K     
Sbjct: 394 LHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHL-------GWELEQLSKNADLS 446

Query: 139 VTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQA 198
               +  +  + EC         A  +I K     +  +S+    RD  +L+L+   L+ 
Sbjct: 447 DASRKSFVFELNEC---------ASSRILKLEKENQSLQSTIQGLRD-ASLVLEESGLKC 496

Query: 199 QLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFL 258
             GE  K    Q+   IE  +  LE    + Q NQ+ ++ L++ L   +E L     D  
Sbjct: 497 --GELEK-ENHQLSKKIEKLQTQLER---EKQSNQD-LETLSEELIREKEQL---QSDME 546

Query: 259 QLRSENQNKEKSWMLEKDNLMSKIKQYRVQCK-------KKEDKIGKVLPVMHESHHAQS 311
            L+++   + K    EKD+L   +   R + +       K  +K  K L       + + 
Sbjct: 547 TLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKL 606

Query: 312 EYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMT 371
             ++  K +L ++ + +    E+   LE EL R++EE G        R  +    L+  T
Sbjct: 607 SQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENG--------RLARKVTSLETAT 658

Query: 372 KRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDL 419
           ++ EALE     E +G + + + LR+ L  L+ +  +     R N+ L
Sbjct: 659 EKVEALEH----ESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQL 702



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 71/344 (20%), Positives = 135/344 (39%), Gaps = 39/344 (11%)

Query: 24   KELLEYYQKKMAECEAENEDLLKKLELYKEACE--------GQHKLECDLQQREEEIAEL 75
            +E +   + +M E  + N  L  +L++ K+ CE        GQH          +  A  
Sbjct: 976  EEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASH 1035

Query: 76   Q------KALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVT 129
            Q          +  + L + ++  + L   N  L+  +   K+++Q+L     T + ++ 
Sbjct: 1036 QGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQIL 1095

Query: 130  YFCKEPP----HKVTILQKT--IQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQ 183
               K+      H  T+  +T  +Q       S+S+A  A   + +   + +  E+ E  Q
Sbjct: 1096 TLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETEN-ESLQ 1154

Query: 184  RDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNL 243
            R  + L    EAL            E +  L E +    E +  QH    + +K L +NL
Sbjct: 1155 RQQEQLTAAYEALLQD--------HEHLGTLHERQSAEYEALIRQH----SCLKTLHRNL 1202

Query: 244  HHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVM 303
                + L E   D L+ ++E + +EK    E++ L  + +   +   + +   G++  V 
Sbjct: 1203 ELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVN 1262

Query: 304  HESHHAQSEY------IKSLKDKLVQEKKLSNMYQEQCISLEEE 341
               H  + EY       K LK  L   +   N +Q +   L+E+
Sbjct: 1263 FLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQ 1306



 Score = 33.9 bits (76), Expect = 0.31
 Identities = 62/349 (17%), Positives = 145/349 (41%), Gaps = 22/349 (6%)

Query: 20   LHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQ--K 77
            L  S    +  + ++ E EAE + L + LE  + A       E D +  E+E+A+L+  K
Sbjct: 775  LESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDK 834

Query: 78   ALSDMQVCLFQEREHVLRLYSENDRLRIRELE-DKKKIQNLLALVGTDAGEVTYFCKEP- 135
             L + +     ++  +     ++   ++  +E + + +   LA     AG++    K+  
Sbjct: 835  KLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNR 894

Query: 136  --PHKVTILQKTIQAVGE--------CEQSESSAFKADPKISKRRPSRERKESSEHYQRD 185
                +VT+  +T+  + E         +Q  S   K   ++ K   +RE     +    D
Sbjct: 895  DLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSD 954

Query: 186  IQTLILQVEALQAQLGEQTKLSREQI---EGLIEDRRIHLEEIQVQHQRNQNKIKELTKN 242
             +  IL+    ++ L     +  E+I   E  +E++     +++ + Q  + + + L +N
Sbjct: 955  TKYKILEGRN-ESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQN 1013

Query: 243  LHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMS--KIKQYRVQCKKKEDKIGKVL 300
                Q L         +  + +Q KE      K+  M   ++K   ++ ++    +    
Sbjct: 1014 QGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEK 1073

Query: 301  PVMHES-HHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREE 348
             ++ E   H +++ + +   +++  +K S   QE   +L+ + A+++ E
Sbjct: 1074 QLLKEQLQHLETQNV-TFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVE 1121


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.130    0.352 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,202,688
Number of Sequences: 37866
Number of extensions: 741422
Number of successful extensions: 6849
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 126
Number of HSP's successfully gapped in prelim test: 763
Number of HSP's that attempted gapping in prelim test: 3951
Number of HSP's gapped (non-prelim): 2378
length of query: 456
length of database: 18,247,518
effective HSP length: 106
effective length of query: 350
effective length of database: 14,233,722
effective search space: 4981802700
effective search space used: 4981802700
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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