BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo sapiens] (421 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ... 880 0.0 gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo ... 547 e-156 gi|8923881 WD SOCS-box protein 2 [Homo sapiens] 394 e-110 gi|113865883 WD repeat domain 38 [Homo sapiens] 132 6e-31 gi|16554629 WD repeat domain 5 [Homo sapiens] 117 3e-26 gi|16554627 WD repeat domain 5 [Homo sapiens] 117 3e-26 gi|23199987 WD repeat domain 5B [Homo sapiens] 110 2e-24 gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 96 5e-20 gi|26665869 WD repeat domain 51B [Homo sapiens] 96 5e-20 gi|32189425 WD repeat domain 69 [Homo sapiens] 93 4e-19 gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 92 9e-19 gi|13376840 WD repeat domain 61 [Homo sapiens] 91 2e-18 gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 90 4e-18 gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 90 4e-18 gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 90 4e-18 gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 90 4e-18 gi|21071067 TBP-associated factor 5 [Homo sapiens] 89 7e-18 gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 89 1e-17 gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 88 2e-17 gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 86 5e-17 gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 86 5e-17 gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 86 5e-17 gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 84 3e-16 gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 83 4e-16 gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 82 1e-15 gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 81 2e-15 gi|148536855 coatomer protein complex, subunit alpha isoform 1 [... 81 2e-15 gi|148536853 coatomer protein complex, subunit alpha isoform 2 [... 81 2e-15 gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 81 2e-15 gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 81 2e-15 >gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo sapiens] Length = 421 Score = 880 bits (2275), Expect = 0.0 Identities = 421/421 (100%), Positives = 421/421 (100%) Query: 1 MASFPPRVNEKEIVRLRTIGELLAPAAPFDKKCGRENWTVAFAPDGSYFAWSQGHRTVKL 60 MASFPPRVNEKEIVRLRTIGELLAPAAPFDKKCGRENWTVAFAPDGSYFAWSQGHRTVKL Sbjct: 1 MASFPPRVNEKEIVRLRTIGELLAPAAPFDKKCGRENWTVAFAPDGSYFAWSQGHRTVKL 60 Query: 61 VPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVP 120 VPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVP Sbjct: 61 VPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVP 120 Query: 121 EKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAP 180 EKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAP Sbjct: 121 EKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAP 180 Query: 181 DGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFL 240 DGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFL Sbjct: 181 DGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFL 240 Query: 241 WNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPP 300 WNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPP Sbjct: 241 WNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPP 300 Query: 301 PTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFS 360 PTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFS Sbjct: 301 PTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFS 360 Query: 361 TDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR 420 TDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR Sbjct: 361 TDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR 420 Query: 421 I 421 I Sbjct: 421 I 421 >gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo sapiens] Length = 275 Score = 547 bits (1410), Expect = e-156 Identities = 262/262 (100%), Positives = 262/262 (100%) Query: 160 GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYS 219 GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYS Sbjct: 14 GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYS 73 Query: 220 CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTR 279 CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTR Sbjct: 74 CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTR 133 Query: 280 VYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR 339 VYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR Sbjct: 134 VYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR 193 Query: 340 IDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVM 399 IDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVM Sbjct: 194 IDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVM 253 Query: 400 PTQEVQELPIPSKLLEFLSYRI 421 PTQEVQELPIPSKLLEFLSYRI Sbjct: 254 PTQEVQELPIPSKLLEFLSYRI 275 Score = 66.2 bits (160), Expect = 5e-11 Identities = 75/295 (25%), Positives = 114/295 (38%), Gaps = 75/295 (25%) Query: 1 MASFPPRVNEKEIVRLRTIGELLAPAAPFDKKCGRENWTVAFAPDGSYFAWSQGHRTVKL 60 MASFPPRVNEKEI G+LL + + FAPDGS S Sbjct: 1 MASFPPRVNEKEI------GKLLLNLVDHTEVVR----DLTFAPDGSLILVS-------- 42 Query: 61 VPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVP 120 + +LR+ DG R H + V+S AF Sbjct: 43 -----------------ASRDKTLRVWDLKDDGNMMKVLRGH----QNWVYSCAFSPD-- 79 Query: 121 EKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAP 180 +L + G + + +W++ ++ L H V F+P Sbjct: 80 ------------------SSMLCSVGASKA-VFLWNMDKYTMIRKLEGHHHDVVACDFSP 120 Query: 181 DGSLILVSASRDKTLRVWDLKDDGNMMK----------VLRGHQN--WVYSCAFSPDSSM 228 DG+L L +AS D + +WD + +M+ + G N WV S +FS D Sbjct: 121 DGAL-LATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLH 179 Query: 229 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIW 283 + S+ K V W +D+ ++ + + C FS DG++LA ++D VY W Sbjct: 180 VASLADDKMVRFWRIDEDYPVQ--VAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 232 >gi|8923881 WD SOCS-box protein 2 [Homo sapiens] Length = 404 Score = 394 bits (1013), Expect = e-110 Identities = 205/400 (51%), Positives = 260/400 (65%), Gaps = 12/400 (3%) Query: 23 LAPAAP--FDKKCGRENWTVAFAPDGSYFAWSQGHRTVKLVPWSQCLQNFLLHGTKNVTN 80 L P P FD K E W+VAF+PDGS+FAWSQGH VKL+PW + F+ G + + Sbjct: 13 LKPGRPHQFDWKSSCETWSVAFSPDGSWFAWSQGHCIVKLIPWP-LEEQFIPKGFEAKSR 71 Query: 81 SSSLRLPRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQ 140 SS +N G + P+E +DCG IVW LAF S P SR + H Sbjct: 72 SS------KNETKG-RGSPKEKTLDCGQIVWGLAF-SPWPSPPSRKLWARHHPQVPDVSC 123 Query: 141 LLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDL 200 L+LATGLN+G+IKIW+V TG LLLNL H +VVRDL+F P GSLILVSASRDKTLR+WDL Sbjct: 124 LVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDL 183 Query: 201 KDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVV 260 G ++VL GH WVY C+ SPD SMLCS K+VFLW+M YT+IRKLEGH VV Sbjct: 184 NKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVV 243 Query: 261 ACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFS 320 +CDFSPD ALL TASYDT V +WDP+ G+ L H P + + +RSV FS Sbjct: 244 SCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPA-MDDSDVHISSLRSVCFS 302 Query: 321 HDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWAT 380 +GL++A++ADD+++R W ++ P+ AP++NGLCC F G V+A GT DG V FW Sbjct: 303 PEGLYLATVADDRLLRIWALELKTPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFWTA 362 Query: 381 PRQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR 420 PR + SL+HLCR ++R + T +V LPIP K+ EFL+YR Sbjct: 363 PRVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 402 >gi|113865883 WD repeat domain 38 [Homo sapiens] Length = 314 Score = 132 bits (332), Expect = 6e-31 Identities = 91/270 (33%), Positives = 134/270 (49%), Gaps = 35/270 (12%) Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195 F D +L TG +G + W+ +G+LL L HT V+ F+PDG L SAS D T+ Sbjct: 29 FSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF-ASASCDCTV 87 Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255 R+WD+ ++VL+GHQ V + +FSPDS L S G K V LW++ M+R L GH Sbjct: 88 RLWDVAR-AKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGH 146 Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWD--------------PHNGDI---------LM 292 + + DFSP LAT S+D+ V+IWD H+ +I L+ Sbjct: 147 RDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLL 206 Query: 293 EFG------HLFPPPTP--IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDY 344 G H++ P T + + WV+S++FS D L +AS +MV+ W + Sbjct: 207 ASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGK 266 Query: 345 PVQV--APLSNGLCCAFSTDGSVLAAGTHD 372 ++ L CAF+ DG +L +G D Sbjct: 267 CLETLKGVLDVAHTCAFTPDGKILVSGAAD 296 Score = 86.3 bits (212), Expect = 5e-17 Identities = 64/224 (28%), Positives = 104/224 (46%), Gaps = 14/224 (6%) Query: 105 DCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLL 164 DC +W +A + + ++E F D LA+G + R+ +WDV +G++L Sbjct: 84 DCTVRLWDVARAKCLRVLKGHQRSVE--TVSFSPDSRQLASGGWDKRVMLWDVQSGQMLR 141 Query: 165 NLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLK--DDGNMMKVLRGHQNWVYSCAF 222 LV H + ++ F+P + L + S D T+ +WDL+ + L GH + SC Sbjct: 142 LLVGHRDSIQSSDFSPTVNC-LATGSWDSTVHIWDLRMVTPAVSHQALEGHSANI-SCLC 199 Query: 223 SPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYI 282 S +L S K + +W +++ +L+GH V + FSPD LA+A Y V + Sbjct: 200 YSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKV 259 Query: 283 WDPHNGDIL------MEFGH--LFPPPTPIFAGGANDRWVRSVS 318 WD + G L ++ H F P I GA D+ R +S Sbjct: 260 WDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQIS 303 Score = 76.3 bits (186), Expect = 5e-14 Identities = 58/186 (31%), Positives = 78/186 (41%), Gaps = 17/186 (9%) Query: 207 MKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSP 266 +K H V S AFSPD ML + V+ W ++ +L GH V C FSP Sbjct: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73 Query: 267 DGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLH 325 DG L A+AS D V +WD L GH R V +VSFS D Sbjct: 74 DGHLFASASCDCTVRLWDVARAKCLRVLKGH--------------QRSVETVSFSPDSRQ 119 Query: 326 VASLADDKMVRFWRIDEDYPVQ--VAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQ 383 +AS DK V W + ++ V + FS + LA G+ D +V+ W Sbjct: 120 LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV 179 Query: 384 VPSLQH 389 P++ H Sbjct: 180 TPAVSH 185 Score = 75.1 bits (183), Expect = 1e-13 Identities = 67/241 (27%), Positives = 109/241 (45%), Gaps = 20/241 (8%) Query: 42 FAPDGSYFAWSQGHRTVKL--VPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKP 99 F+PDG FA + TV+L V ++CL+ H ++V S RQ + GG + Sbjct: 71 FSPDGHLFASASCDCTVRLWDVARAKCLRVLKGH-QRSVETVSFSPDSRQLASGGWDKRV 129 Query: 100 REHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYT 159 ++W + G + +I+ F LATG + + IWD+ Sbjct: 130 ---------MLWDVQSGQMLRLLVGHRDSIQ--SSDFSPTVNCLATGSWDSTVHIWDLRM 178 Query: 160 GKLLLN---LVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNW 216 ++ L H+ + L ++ G +L S S DKT+ +W +++ L+GH W Sbjct: 179 VTPAVSHQALEGHSANISCLCYSASG--LLASGSWDKTIHIWK-PTTSSLLIQLKGHVTW 235 Query: 217 VYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASY 276 V S AFSPD L S G S+ V +W+ + + L+G C F+PDG +L + + Sbjct: 236 VKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAA 295 Query: 277 D 277 D Sbjct: 296 D 296 >gi|16554629 WD repeat domain 5 [Homo sapiens] Length = 334 Score = 117 bits (292), Expect = 3e-26 Identities = 74/249 (29%), Positives = 121/249 (48%), Gaps = 19/249 (7%) Query: 135 RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKT 194 +F + LA+ + IKIW Y GK + H + D+ ++ D +L LVSAS DKT Sbjct: 52 KFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL-LVSASDDKT 110 Query: 195 LRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEG 254 L++WD+ G +K L+GH N+V+ C F+P S+++ S ++V +W++ ++ L Sbjct: 111 LKIWDVSS-GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPA 169 Query: 255 HHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWV 314 H V A F+ DG+L+ ++SYD IWD +G L PP V Sbjct: 170 HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP------------V 217 Query: 315 RSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQV-APLSNGLCCAFS----TDGSVLAAG 369 V FS +G ++ + D ++ W + ++ N C F+ T G + +G Sbjct: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSG 277 Query: 370 THDGSVYFW 378 + D VY W Sbjct: 278 SEDNLVYIW 286 Score = 97.8 bits (242), Expect = 2e-20 Identities = 66/227 (29%), Positives = 105/227 (46%), Gaps = 32/227 (14%) Query: 162 LLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCA 221 L L HT+ V + F+P+G L S+S DK +++W DG K + GH+ + A Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAY-DGKFEKTISGHKLGISDVA 94 Query: 222 FSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVY 281 +S DS++L S K + +W++ ++ L+GH + V C+F+P L+ + S+D V Sbjct: 95 WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154 Query: 282 IWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW--- 338 IWD G L A+ V +V F+ DG + S + D + R W Sbjct: 155 IWDVKTGKCLKTL-------------PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201 Query: 339 -------RIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378 ID+D P P+S FS +G + A T D ++ W Sbjct: 202 SGQCLKTLIDDDNP----PVS---FVKFSPNGKYILAATLDNTLKLW 241 Score = 71.2 bits (173), Expect = 2e-12 Identities = 46/155 (29%), Positives = 80/155 (51%), Gaps = 10/155 (6%) Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEV-VRDLTFAPDGSLILVSASRDKT 194 F +D L+ + +G +IWD +G+ L L+D V + F+P+G IL +A+ D T Sbjct: 179 FNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYIL-AATLDNT 237 Query: 195 LRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDS----SMLCSVGASKAVFLWNMDKYTMIR 250 L++WD G +K GH+N Y C F+ S + S V++WN+ +++ Sbjct: 238 LKLWDYSK-GKCLKTYTGHKNEKY-CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ 295 Query: 251 KLEGHHHDVVACDFSPDGALLATASY--DTRVYIW 283 KL+GH V++ P ++A+A+ D + +W Sbjct: 296 KLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 Score = 61.2 bits (147), Expect = 2e-09 Identities = 46/174 (26%), Positives = 72/174 (41%), Gaps = 17/174 (9%) Query: 210 LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGA 269 L GH V S FSP+ L S A K + +W + + GH + +S D Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100 Query: 270 LLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVAS 328 LL +AS D + IWD +G L GH +V +F+ + S Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGH--------------SNYVFCCNFNPQSNLIVS 146 Query: 329 LADDKMVRFWRIDEDYPVQVAPLSNGLCCA--FSTDGSVLAAGTHDGSVYFWAT 380 + D+ VR W + ++ P + A F+ DGS++ + ++DG W T Sbjct: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200 Score = 50.8 bits (120), Expect = 2e-06 Identities = 36/136 (26%), Positives = 61/136 (44%), Gaps = 17/136 (12%) Query: 246 YTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPI 304 Y + L GH V + FSP+G LA++S D + IW ++G GH Sbjct: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKL------ 88 Query: 305 FAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTD 362 G +D V++S D + S +DDK ++ W + ++ + CC F+ Sbjct: 89 ---GISD-----VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ 140 Query: 363 GSVLAAGTHDGSVYFW 378 +++ +G+ D SV W Sbjct: 141 SNLIVSGSFDESVRIW 156 >gi|16554627 WD repeat domain 5 [Homo sapiens] Length = 334 Score = 117 bits (292), Expect = 3e-26 Identities = 74/249 (29%), Positives = 121/249 (48%), Gaps = 19/249 (7%) Query: 135 RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKT 194 +F + LA+ + IKIW Y GK + H + D+ ++ D +L LVSAS DKT Sbjct: 52 KFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL-LVSASDDKT 110 Query: 195 LRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEG 254 L++WD+ G +K L+GH N+V+ C F+P S+++ S ++V +W++ ++ L Sbjct: 111 LKIWDVSS-GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPA 169 Query: 255 HHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWV 314 H V A F+ DG+L+ ++SYD IWD +G L PP V Sbjct: 170 HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP------------V 217 Query: 315 RSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQV-APLSNGLCCAFS----TDGSVLAAG 369 V FS +G ++ + D ++ W + ++ N C F+ T G + +G Sbjct: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSG 277 Query: 370 THDGSVYFW 378 + D VY W Sbjct: 278 SEDNLVYIW 286 Score = 97.8 bits (242), Expect = 2e-20 Identities = 66/227 (29%), Positives = 105/227 (46%), Gaps = 32/227 (14%) Query: 162 LLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCA 221 L L HT+ V + F+P+G L S+S DK +++W DG K + GH+ + A Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAY-DGKFEKTISGHKLGISDVA 94 Query: 222 FSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVY 281 +S DS++L S K + +W++ ++ L+GH + V C+F+P L+ + S+D V Sbjct: 95 WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154 Query: 282 IWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW--- 338 IWD G L A+ V +V F+ DG + S + D + R W Sbjct: 155 IWDVKTGKCLKTL-------------PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201 Query: 339 -------RIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378 ID+D P P+S FS +G + A T D ++ W Sbjct: 202 SGQCLKTLIDDDNP----PVS---FVKFSPNGKYILAATLDNTLKLW 241 Score = 71.2 bits (173), Expect = 2e-12 Identities = 46/155 (29%), Positives = 80/155 (51%), Gaps = 10/155 (6%) Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEV-VRDLTFAPDGSLILVSASRDKT 194 F +D L+ + +G +IWD +G+ L L+D V + F+P+G IL +A+ D T Sbjct: 179 FNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYIL-AATLDNT 237 Query: 195 LRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDS----SMLCSVGASKAVFLWNMDKYTMIR 250 L++WD G +K GH+N Y C F+ S + S V++WN+ +++ Sbjct: 238 LKLWDYSK-GKCLKTYTGHKNEKY-CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ 295 Query: 251 KLEGHHHDVVACDFSPDGALLATASY--DTRVYIW 283 KL+GH V++ P ++A+A+ D + +W Sbjct: 296 KLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 Score = 61.2 bits (147), Expect = 2e-09 Identities = 46/174 (26%), Positives = 72/174 (41%), Gaps = 17/174 (9%) Query: 210 LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGA 269 L GH V S FSP+ L S A K + +W + + GH + +S D Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100 Query: 270 LLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVAS 328 LL +AS D + IWD +G L GH +V +F+ + S Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGH--------------SNYVFCCNFNPQSNLIVS 146 Query: 329 LADDKMVRFWRIDEDYPVQVAPLSNGLCCA--FSTDGSVLAAGTHDGSVYFWAT 380 + D+ VR W + ++ P + A F+ DGS++ + ++DG W T Sbjct: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200 Score = 50.8 bits (120), Expect = 2e-06 Identities = 36/136 (26%), Positives = 61/136 (44%), Gaps = 17/136 (12%) Query: 246 YTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPI 304 Y + L GH V + FSP+G LA++S D + IW ++G GH Sbjct: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKL------ 88 Query: 305 FAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTD 362 G +D V++S D + S +DDK ++ W + ++ + CC F+ Sbjct: 89 ---GISD-----VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ 140 Query: 363 GSVLAAGTHDGSVYFW 378 +++ +G+ D SV W Sbjct: 141 SNLIVSGSFDESVRIW 156 >gi|23199987 WD repeat domain 5B [Homo sapiens] Length = 330 Score = 110 bits (275), Expect = 2e-24 Identities = 73/249 (29%), Positives = 115/249 (46%), Gaps = 19/249 (7%) Query: 135 RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKT 194 +F + LA+ + I IW Y GK L H + D+ ++ D S LVSAS DKT Sbjct: 48 KFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSR-LVSASDDKT 106 Query: 195 LRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEG 254 L++WD++ G +K L+GH N+V+ C F+P S+++ S + V +W + ++ L Sbjct: 107 LKLWDVRS-GKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSA 165 Query: 255 HHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWV 314 H V A F+ G+L+ + SYD IWD +G L PP V Sbjct: 166 HSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPP------------V 213 Query: 315 RSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQV-APLSNGLCCAFS----TDGSVLAAG 369 V FS +G ++ + D ++ W ++ N C F+ T G + +G Sbjct: 214 SFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSG 273 Query: 370 THDGSVYFW 378 + D VY W Sbjct: 274 SEDNLVYIW 282 Score = 79.0 bits (193), Expect = 8e-15 Identities = 62/241 (25%), Positives = 107/241 (44%), Gaps = 17/241 (7%) Query: 109 IVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVD 168 I+W G EK N+E + D L + ++ +K+WDV +GK L L Sbjct: 66 IIWGAYDGKY--EKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKG 123 Query: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 228 H+ V F P +LI +S S D+T+++W++K G +K L H + V + F+ S+ Sbjct: 124 HSNYVFCCNFNPPSNLI-ISGSFDETVKIWEVK-TGKCLKTLSAHSDPVSAVHFNCSGSL 181 Query: 229 LCSVGASKAVFLWNMDKYTMIRKL-EGHHHDVVACDFSPDGALLATASYDTRVYIWDPHN 287 + S +W+ ++ L + + V FSP+G + TA+ D + +WD Sbjct: 182 IVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSR 241 Query: 288 GDILMEFGHLFPPPTPIFAGGANDRWVRSVSFS-HDGLHVASLADDKMVRFWRIDEDYPV 346 G L + G N+++ +FS G + S ++D +V W + V Sbjct: 242 GRCL-----------KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 290 Query: 347 Q 347 Q Sbjct: 291 Q 291 Score = 71.2 bits (173), Expect = 2e-12 Identities = 47/149 (31%), Positives = 78/149 (52%), Gaps = 10/149 (6%) Query: 142 LLATGLNNGRIKIWDVYTGKLLLNLVDHTEV-VRDLTFAPDGSLILVSASRDKTLRVWDL 200 L+ +G +G +IWD +G+ L LVD V + F+P+G IL +A+ D TL++WD Sbjct: 181 LIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYIL-TATLDNTLKLWDY 239 Query: 201 KDDGNMMKVLRGHQNWVYSCAFSPDS----SMLCSVGASKAVFLWNMDKYTMIRKLEGHH 256 G +K GH+N Y C F+ S + S V++WN+ +++KL+GH Sbjct: 240 SR-GRCLKTYTGHKNEKY-CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT 297 Query: 257 HDVVACDFSPDGALLATASY--DTRVYIW 283 V++ P L+A+A+ D + +W Sbjct: 298 DVVISAACHPTENLIASAALENDKTIKLW 326 Score = 55.1 bits (131), Expect = 1e-07 Identities = 41/172 (23%), Positives = 72/172 (41%), Gaps = 17/172 (9%) Query: 210 LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGA 269 L GH V S FSP+ L S A + + +W + L GH+ ++ +S D + Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSS 96 Query: 270 LLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVAS 328 L +AS D + +WD +G L GH +V +F+ + S Sbjct: 97 RLVSASDDKTLKLWDVRSGKCLKTLKGH--------------SNYVFCCNFNPPSNLIIS 142 Query: 329 LADDKMVRFWRIDEDYPVQVAPLSNGLCCA--FSTDGSVLAAGTHDGSVYFW 378 + D+ V+ W + ++ + A F+ GS++ +G++DG W Sbjct: 143 GSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194 Score = 50.4 bits (119), Expect = 3e-06 Identities = 33/136 (24%), Positives = 61/136 (44%), Gaps = 17/136 (12%) Query: 246 YTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILME-FGHLFPPPTPI 304 Y + L GH V + FSP+G LA++S D + IW ++G +GH Sbjct: 31 YALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGH-------- 82 Query: 305 FAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTD 362 + + V++S D + S +DDK ++ W + ++ + CC F+ Sbjct: 83 ------NLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPP 136 Query: 363 GSVLAAGTHDGSVYFW 378 +++ +G+ D +V W Sbjct: 137 SNLIISGSFDETVKIW 152 >gi|83779014 katanin p80 subunit B 1 [Homo sapiens] Length = 655 Score = 96.3 bits (238), Expect = 5e-20 Identities = 71/245 (28%), Positives = 112/245 (45%), Gaps = 20/245 (8%) Query: 142 LLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLK 201 LLATG ++ R+ +W + +++L HT V + LI V+ S+ ++RVWDL Sbjct: 35 LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI-VAGSQSGSIRVWDL- 92 Query: 202 DDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVA 261 + +++ L GH+ + S F P + S + LW++ + + + GH V Sbjct: 93 EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRC 152 Query: 262 CDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFS 320 FSPDG LA+A+ D V +WD G ++ EF GH P V V F Sbjct: 153 LRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGP--------------VNVVEFH 198 Query: 321 HDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDG-SVYF 377 + +AS + D+ +RFW +++ V G F+ DG L +G D VY Sbjct: 199 PNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYG 258 Query: 378 WATPR 382 W R Sbjct: 259 WEPER 263 Score = 89.7 bits (221), Expect = 4e-18 Identities = 63/230 (27%), Positives = 100/230 (43%), Gaps = 17/230 (7%) Query: 105 DCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLL 164 DC +WS+ + + +E R + L+ G +G I++WD+ K+L Sbjct: 42 DCRVNLWSINKPNCIMSLTGHTSPVE--SVRLNTPEELIVAGSQSGSIRVWDLEAAKILR 99 Query: 165 NLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSP 224 L+ H + L F P G + S S+D +++WD++ G + + RGH V FSP Sbjct: 100 TLMGHKANICSLDFHPYGEFV-ASGSQDTNIKLWDIRRKGCVFR-YRGHSQAVRCLRFSP 157 Query: 225 DSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 284 D L S V LW++ M+ + GH V +F P+ LLA+ S D + WD Sbjct: 158 DGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217 Query: 285 PHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKM 334 ++ + P P VRSV F+ DG + S D + Sbjct: 218 LEKFQVV---SCIEGEPGP----------VRSVLFNPDGCCLYSGCQDSL 254 Score = 34.3 bits (77), Expect = 0.22 Identities = 37/142 (26%), Positives = 52/142 (36%), Gaps = 31/142 (21%) Query: 268 GALLATASYDTRVYIWDPHNGDILMEF-GHLFP-------PPTPIFAGGANDRWVR---- 315 G LLAT D RV +W + + +M GH P P + G+ +R Sbjct: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDL 92 Query: 316 -----------------SVSFSHDGLHVASLADDKMVRFWRIDEDYPV-QVAPLSNGL-C 356 S+ F G VAS + D ++ W I V + S + C Sbjct: 93 EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRC 152 Query: 357 CAFSTDGSVLAAGTHDGSVYFW 378 FS DG LA+ D +V W Sbjct: 153 LRFSPDGKWLASAADDHTVKLW 174 Score = 31.2 bits (69), Expect = 1.8 Identities = 26/91 (28%), Positives = 44/91 (48%), Gaps = 8/91 (8%) Query: 110 VWSLAFGSSVPEKQSRC--VNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLV 167 +W L G + E VN+ F ++ LLA+G ++ I+ WD+ +++ + Sbjct: 173 LWDLTAGKMMSEFPGHTGPVNV----VEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIE 228 Query: 168 DHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198 VR + F PDG L S +D +LRV+ Sbjct: 229 GEPGPVRSVLFNPDG-CCLYSGCQD-SLRVY 257 >gi|26665869 WD repeat domain 51B [Homo sapiens] Length = 478 Score = 96.3 bits (238), Expect = 5e-20 Identities = 68/235 (28%), Positives = 106/235 (45%), Gaps = 17/235 (7%) Query: 143 LATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKD 202 LAT + + +W+ V H +VV + F+P G+L L SASRD+T+R+W + D Sbjct: 33 LATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNL-LASASRDRTVRLW-IPD 90 Query: 203 DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVAC 262 + H V S FS D L + K++ +W+M + + L H H V Sbjct: 91 KRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCA 150 Query: 263 DFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHD 322 FSPDG L+ + S D + IWD N + F G AN V F+ Sbjct: 151 KFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSD--------SVGFAN-----FVDFNPS 197 Query: 323 GLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSV 375 G +AS D+ V+ W + + +Q + +G C +F G+ L + DG++ Sbjct: 198 GTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTL 252 Score = 91.7 bits (226), Expect = 1e-18 Identities = 72/233 (30%), Positives = 104/233 (44%), Gaps = 26/233 (11%) Query: 119 VPEKQSRCVNIEWHR-----FRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVV 173 +P+K+ + + H F D LAT + IK+W +Y + L +L HT V Sbjct: 88 IPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWV 147 Query: 174 RDLTFAPDGSLILVSASRDKTLRVWDL--KDDGNMMKVLRGHQNWVYSCAFSPDSSMLCS 231 R F+PDG LI VS S DKT+++WD K N G N+V F+P + + S Sbjct: 148 RCAKFSPDGRLI-VSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFV---DFNPSGTCIAS 203 Query: 232 VGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDIL 291 G+ + V +W++ +++ + H V F P G L TAS D + I D G ++ Sbjct: 204 AGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLI 263 Query: 292 MEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDED 343 GH P V +VSFS G AS D V WR + D Sbjct: 264 YTLQGHTGP--------------VFTVSFSKGGELFASGGADTQVLLWRTNFD 302 Score = 86.7 bits (213), Expect = 4e-17 Identities = 60/212 (28%), Positives = 92/212 (43%), Gaps = 17/212 (8%) Query: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 228 H + L +P+G L +AS D L +W+ K + + GH++ V S FSP ++ Sbjct: 17 HKAAITSLDLSPNGKQ-LATASWDTFLMLWNFKPHARAYRYV-GHKDVVTSVQFSPHGNL 74 Query: 229 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNG 288 L S + V LW DK + + H V + DFS DG LATAS D + +W + Sbjct: 75 LASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQ 134 Query: 289 DILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQV 348 L ++ + WVR FS DG + S ++DK ++ W V Sbjct: 135 RFL-------------YSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181 Query: 349 APLSNGLC--CAFSTDGSVLAAGTHDGSVYFW 378 S G F+ G+ +A+ D +V W Sbjct: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVW 213 Score = 76.3 bits (186), Expect = 5e-14 Identities = 51/182 (28%), Positives = 84/182 (46%), Gaps = 17/182 (9%) Query: 202 DDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVA 261 +D + + +GH+ + S SP+ L + + LWN + + GH V + Sbjct: 6 EDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTS 65 Query: 262 CDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFS 320 FSP G LLA+AS D V +W P EF H P VRSV FS Sbjct: 66 VQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAP--------------VRSVDFS 111 Query: 321 HDGLHVASLADDKMVRFWRI-DEDYPVQVAPLSNGLCCA-FSTDGSVLAAGTHDGSVYFW 378 DG +A+ ++DK ++ W + + + + ++ + CA FS DG ++ + + D ++ W Sbjct: 112 ADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW 171 Query: 379 AT 380 T Sbjct: 172 DT 173 Score = 61.6 bits (148), Expect = 1e-09 Identities = 43/139 (30%), Positives = 64/139 (46%), Gaps = 21/139 (15%) Query: 250 RKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGA 309 R +GH + + D SP+G LATAS+DT + +W+ F P + Sbjct: 12 RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWN-------------FKPHARAYRYVG 58 Query: 310 NDRWVRSVSFSHDGLHVASLADDKMVRFWRIDE-----DYPVQVAPLSNGLCCAFSTDGS 364 + V SV FS G +AS + D+ VR W D+ ++ AP+ + FS DG Sbjct: 59 HKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRS---VDFSADGQ 115 Query: 365 VLAAGTHDGSVYFWATPRQ 383 LA + D S+ W+ RQ Sbjct: 116 FLATASEDKSIKVWSMYRQ 134 >gi|32189425 WD repeat domain 69 [Homo sapiens] Length = 415 Score = 93.2 bits (230), Expect = 4e-19 Identities = 85/342 (24%), Positives = 137/342 (40%), Gaps = 28/342 (8%) Query: 40 VAFAPDGSYFAWSQGHRTVKLVPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKP 99 VA GS F RT KL + + L G +NV + + N+ G K Sbjct: 98 VALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAF-----NNPYGDKIAT 152 Query: 100 REHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYT 159 C +WS+ G + I F L+ATG + K+WD+ Sbjct: 153 GSFDKTCK--LWSVETGKCYHTFRGHTAEIVC--LSFNPQSTLVATGSMDTTAKLWDIQN 208 Query: 160 GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYS 219 G+ + L H+ + L+F G I ++ S D T+ VWD D G + +L GH + S Sbjct: 209 GEEVYTLRGHSAEIISLSFNTSGDRI-ITGSFDHTVVVWD-ADTGRKVNILIGHCAEISS 266 Query: 220 CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTR 279 +F+ D S++ + K LW+ + L GH +++ F G L+ATAS D Sbjct: 267 ASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGT 326 Query: 280 VYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW 338 I+ + + GH + + +SF+ G H+ + + DK R W Sbjct: 327 ARIFSAATRKCIAKLEGH--------------EGEISKISFNPQGNHLLTGSSDKTARIW 372 Query: 339 RIDEDYPVQV--APLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378 +QV CAF+ G+++ G+ D + W Sbjct: 373 DAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414 Score = 82.0 bits (201), Expect = 9e-16 Identities = 59/230 (25%), Positives = 98/230 (42%), Gaps = 17/230 (7%) Query: 110 VWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDH 169 +W + G V + I F D+++ TG + + +WD TG+ + L+ H Sbjct: 203 LWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII--TGSFDHTVVVWDADTGRKVNILIGH 260 Query: 170 TEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSML 229 + +F D SLIL + S DKT ++WD + G + L GH + + F ++ Sbjct: 261 CAEISSASFNWDCSLIL-TGSMDKTCKLWDATN-GKCVATLTGHDDEILDSCFDYTGKLI 318 Query: 230 CSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGD 289 + A +++ I KLEGH ++ F+P G L T S D IWD G Sbjct: 319 ATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQ 378 Query: 290 ILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR 339 L + G ++ + S +F++ G V + + D R WR Sbjct: 379 CLQ-----------VLEGHTDE--IFSCAFNYKGNIVITGSKDNTCRIWR 415 Score = 76.3 bits (186), Expect = 5e-14 Identities = 60/251 (23%), Positives = 107/251 (42%), Gaps = 24/251 (9%) Query: 145 TGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDG 204 TG + K+WD +G+ L L H VV + F + + S DKT ++W + + G Sbjct: 109 TGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSV-ETG 167 Query: 205 NMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDF 264 RGH + +F+P S+++ + LW++ + L GH ++++ F Sbjct: 168 KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSF 227 Query: 265 SPDGALLATASYDTRVYIWDPHNG-DILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDG 323 + G + T S+D V +WD G + + GH + S SF+ D Sbjct: 228 NTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAE--------------ISSASFNWDC 273 Query: 324 LHVASLADDKMVRFWRIDEDYPVQVAPLSNG----LCCAFSTDGSVLAAGTHDGS--VYF 377 + + + DK + W D VA L+ L F G ++A + DG+ ++ Sbjct: 274 SLILTGSMDKTCKLW--DATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFS 331 Query: 378 WATPRQVPSLQ 388 AT + + L+ Sbjct: 332 AATRKCIAKLE 342 Score = 44.7 bits (104), Expect = 2e-04 Identities = 42/178 (23%), Positives = 72/178 (40%), Gaps = 20/178 (11%) Query: 206 MMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDF- 264 + KVL+ H + + A + S + + LW+ + LEGH + V A F Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143 Query: 265 SPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDG 323 +P G +AT S+D +W G F GH + +SF+ Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAE--------------IVCLSFNPQS 189 Query: 324 LHVASLADDKMVRFWRI---DEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378 VA+ + D + W I +E Y ++ + + +F+T G + G+ D +V W Sbjct: 190 TLVATGSMDTTAKLWDIQNGEEVYTLR-GHSAEIISLSFNTSGDRIITGSFDHTVVVW 246 Score = 33.1 bits (74), Expect = 0.49 Identities = 26/135 (19%), Positives = 56/135 (41%), Gaps = 14/135 (10%) Query: 246 YTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIF 305 + + + L+ H + + G+ T SYD +WD +G+ E L ++ Sbjct: 82 FYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGE---ELNTLEGHRNVVY 138 Query: 306 AGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRID--EDYPVQVAPLSNGLCCAFSTDG 363 A N+ + G +A+ + DK + W ++ + Y + +C +F+ Sbjct: 139 AIAFNNPY---------GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQS 189 Query: 364 SVLAAGTHDGSVYFW 378 +++A G+ D + W Sbjct: 190 TLVATGSMDTTAKLW 204 >gi|62234461 Notchless gene homolog isoform a [Homo sapiens] Length = 485 Score = 92.0 bits (227), Expect = 9e-19 Identities = 95/379 (25%), Positives = 147/379 (38%), Gaps = 91/379 (24%) Query: 39 TVAFAPDGSYFAWSQGHRTVKLVPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNK 98 +VAF+P G Y A G TV+ S +F G ++ S S + G KN Sbjct: 119 SVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKN- 177 Query: 99 PREHIIDCGDIV-WSLAFGSSVPEKQSR----CVNIEWHRFRFGQDQLLLATGLNNGRIK 153 G I+ W + G V + + W + +A+ +G ++ Sbjct: 178 --------GQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVR 229 Query: 154 IWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGH 213 IWD G+ L HT+ V L + DG +L SAS+D+T++VW DG + + L+GH Sbjct: 230 IWDTTAGRCERILTGHTQSVTCLRWGGDG--LLYSASQDRTIKVW-RAHDGVLCRTLQGH 286 Query: 214 QNWVYSCAFSPDSSM------------------------------------------LCS 231 +WV + A S D ++ L S Sbjct: 287 GHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVS 346 Query: 232 VGASKAVFLWN--MDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGD 289 +FLW+ DK + R + GH + FSPD ++A+AS+D + +WD G Sbjct: 347 GSDDFTLFLWSPAEDKKPLTR-MTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGK 405 Query: 290 ILMEF-GHL-------FPPPTPIFAGGANDR----W-----------------VRSVSFS 320 L GH+ + + + G++D W V +V +S Sbjct: 406 YLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWS 465 Query: 321 HDGLHVASLADDKMVRFWR 339 DG VAS DK +R WR Sbjct: 466 PDGQRVASGGKDKCLRIWR 484 Score = 63.2 bits (152), Expect = 4e-10 Identities = 58/230 (25%), Positives = 90/230 (39%), Gaps = 42/230 (18%) Query: 160 GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYS 219 GK L + TE V D+ + P + + +R L GH V S Sbjct: 74 GKTLESQAVETEKVLDIIYQPQAIFRVRAVTR--------------CTSSLEGHSEAVIS 119 Query: 220 CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTR 279 AFSP L S V W++ T +GH H V++ +SPDG LA+ + + Sbjct: 120 VAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQ 179 Query: 280 VYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSF-----SHDGLHVASLADDKM 334 + +WDP G + G + +W+ +S+ + + +VAS + D Sbjct: 180 ILLWDPSTG---KQVGRTL---------AGHSKWITGLSWEPLHANPECRYVASSSKDGS 227 Query: 335 VRFW--------RIDEDYPVQVAPL---SNGLCCAFSTDGSVLAAGTHDG 373 VR W RI + V L +GL + S D ++ HDG Sbjct: 228 VRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDG 277 >gi|13376840 WD repeat domain 61 [Homo sapiens] Length = 305 Score = 90.9 bits (224), Expect = 2e-18 Identities = 49/149 (32%), Positives = 82/149 (55%), Gaps = 2/149 (1%) Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195 + D LA+G +G I I+D+ TGKLL L H +R LTF+PD L LV+AS D + Sbjct: 156 YSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQL-LVTASDDGYI 214 Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255 +++D++ N+ L GH +WV + AF PD + S + K+V +W++ T + H Sbjct: 215 KIYDVQH-ANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDH 273 Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWD 284 V ++ +G+ + + D ++I+D Sbjct: 274 QDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302 Score = 68.6 bits (166), Expect = 1e-11 Identities = 59/260 (22%), Positives = 109/260 (41%), Gaps = 42/260 (16%) Query: 108 DIVWSLAFGSSVPEKQSRCV----------------------NIEWHRFRFGQDQL---- 141 D +WS+A+G++ E V ++E H+ + Sbjct: 17 DAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTL 76 Query: 142 -LLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDL 200 + A+ + I++WD+ GK + ++ L F+PD S L + + + ++ + Sbjct: 77 PIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPD-SQYLATGTHVGKVNIFGV 135 Query: 201 KDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVV 260 + G L ++ S A+SPD L S + ++++ ++ LEGH + Sbjct: 136 -ESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIR 194 Query: 261 ACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFS 320 + FSPD LL TAS D + I+D + ++ +G A+ WV +V+F Sbjct: 195 SLTFSPDSQLLVTASDDGYIKIYDVQHANL-----------AGTLSGHAS--WVLNVAFC 241 Query: 321 HDGLHVASLADDKMVRFWRI 340 D H S + DK V+ W + Sbjct: 242 PDDTHFVSSSSDKSVKVWDV 261 Score = 45.8 bits (107), Expect = 7e-05 Identities = 42/181 (23%), Positives = 79/181 (43%), Gaps = 23/181 (12%) Query: 204 GNMMKVLRGHQNWVYSCAF------SPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHH 257 G + K + H + ++S A+ + ++ + S+ V+ W ++ + LEGH Sbjct: 6 GILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQL 65 Query: 258 DVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSV 317 VV+ D S + A++S D + +WD NG + G D W ++ Sbjct: 66 GVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSID-----------AGPVDAW--TL 112 Query: 318 SFSHDGLHVASLADDKMVRFWRID---EDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGS 374 +FS D ++A+ V + ++ ++Y + L A+S DG LA+G DG Sbjct: 113 AFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRG-KFILSIAYSPDGKYLASGAIDGI 171 Query: 375 V 375 + Sbjct: 172 I 172 >gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo sapiens] Length = 1205 Score = 89.7 bits (221), Expect = 4e-18 Identities = 87/337 (25%), Positives = 141/337 (41%), Gaps = 42/337 (12%) Query: 34 GRENWT--VAFAPDGSYFAWSQGHRTVKLVPWSQCLQN------------FLLHGTKNVT 79 G +W V F+PDGS F S +T++L + +N F + + Sbjct: 837 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 896 Query: 80 NSSSLRLPRQNSDGGQKNKPREHIIDC---GDIVWSLAFG-------------SSVPEKQ 123 RL N GQ + E + C + +AFG + + + + Sbjct: 897 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 956 Query: 124 SRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGS 183 + WH +F D+ L + ++ I++W+ K + L H E V+D + Sbjct: 957 FQHKKTVWH-IQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSR 1014 Query: 184 LILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNM 243 L+ S S D T++VW++ GN K HQ V SC S D++ S A K +W+ Sbjct: 1015 LL--SWSFDGTVKVWNI-ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSF 1071 Query: 244 DKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTP 303 D + +L GH+ V FS D LLAT + + IW+ NG++L HL P + Sbjct: 1072 DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL----HLCAPLSE 1127 Query: 304 IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRI 340 A + WV + FS DG + S +++W + Sbjct: 1128 EGA-ATHGGWVTDLCFSPDGKMLISAGG--YIKWWNV 1161 Score = 84.7 bits (208), Expect = 1e-16 Identities = 79/286 (27%), Positives = 124/286 (43%), Gaps = 43/286 (15%) Query: 76 KNVTNSSSLRLPRQNSDGGQK---NKPREHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWH 132 KN+TN S L + R ++D ++ + I CG F + EK + I+ H Sbjct: 601 KNITNLSRL-VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEK---LLEIKAH 656 Query: 133 RFR-----FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDG-SLIL 186 F D +AT + ++KIW+ TG+L+ +H+E V F L+L Sbjct: 657 EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLL 716 Query: 187 VSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLW----- 241 + S D L++WDL + + GH N V C FSPD +L S A + LW Sbjct: 717 ATGSSDCFLKLWDL-NQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSA 775 Query: 242 NMDKYTMIRK----LEGHHHD----VVACDFSPDGALLATASYDTRVYIWDPHNGDILME 293 N K +++ LE D V C +S DGA + A+ ++++W+ + + + Sbjct: 776 NERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSKVAD 834 Query: 294 F-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW 338 GHL WV V FS DG + +DD+ +R W Sbjct: 835 CRGHL--------------SWVHGVMFSPDGSSFLTSSDDQTIRLW 866 Score = 78.6 bits (192), Expect = 1e-14 Identities = 55/193 (28%), Positives = 83/193 (43%), Gaps = 26/193 (13%) Query: 110 VWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDH 169 +W+ G V + F LLLATG ++ +K+WD+ + + H Sbjct: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742 Query: 170 TEVVRDLTFAPDGSLILVSASRDKTLRVWD------------------LKDDGNMMKVLR 211 T V F+PD L L S S D TL++WD L+D M+V+ Sbjct: 743 TNSVNHCRFSPDDKL-LASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI- 800 Query: 212 GHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALL 271 V C++S D + + V A +FLWN D + + GH V FSPDG+ Sbjct: 801 -----VKCCSWSADGARIM-VAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 854 Query: 272 ATASYDTRVYIWD 284 T+S D + +W+ Sbjct: 855 LTSSDDQTIRLWE 867 Score = 71.2 bits (173), Expect = 2e-12 Identities = 69/284 (24%), Positives = 118/284 (41%), Gaps = 19/284 (6%) Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195 F +D +A+ + ++++ TG+ LL + H + V F+ D I + S DK + Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFI-ATCSVDKKV 681 Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFL--WNMDKYTMIRKLE 253 ++W+ G ++ H V C F+ S L S FL W++++ + Sbjct: 682 KIWNSMT-GELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMF 740 Query: 254 GHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGD------ILMEFGHLFPPPTPIFAG 307 GH + V C FSPD LLA+ S D + +WD + + + F +L P + Sbjct: 741 GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM--- 797 Query: 308 GANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAP--LSNGLCCAFSTDGSV 365 + V+ S+S DG + A +K+ W D V LS FS DGS Sbjct: 798 ---EVIVKCCSWSADGARIMVAAKNKIF-LWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 853 Query: 366 LAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVMPTQEVQELPI 409 + D ++ W T + + + + + V EV L + Sbjct: 854 FLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAV 897 Score = 67.0 bits (162), Expect = 3e-11 Identities = 59/230 (25%), Positives = 92/230 (40%), Gaps = 35/230 (15%) Query: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 228 HT+ V F+ DG I S DKTL+V+ + G + ++ H++ V CAFS D Sbjct: 614 HTDAVYHACFSEDGQRI-ASCGADKTLQVFKA-ETGEKLLEIKAHEDEVLCCAFSTDDRF 671 Query: 229 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDF--SPDGALLATASYDTRVYIWDPH 286 + + K V +WN ++ + H V C F S LLAT S D + +WD + Sbjct: 672 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 731 Query: 287 NGDIL-MEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW---RIDE 342 + FGH V FS D +AS + D ++ W +E Sbjct: 732 QKECRNTMFGH--------------TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE 777 Query: 343 DYPVQVAPLSNGL------------CCAFSTDGSVLAAGTHDGSVYFWAT 380 + V L CC++S DG+ + + ++ W T Sbjct: 778 RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN-KIFLWNT 826 Score = 65.5 bits (158), Expect = 9e-11 Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 17/174 (9%) Query: 209 VLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDG 268 V+R H + VY FS D + S GA K + ++ + + +++ H +V+ C FS D Sbjct: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669 Query: 269 ALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLH--V 326 +AT S D +V IW+ G+++ + + V F++ H + Sbjct: 670 RFIATCSVDKKVKIWNSMTGELVHTYDE-------------HSEQVNCCHFTNSSHHLLL 716 Query: 327 ASLADDKMVRFWRID--EDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378 A+ + D ++ W ++ E ++ C FS D +LA+ + DG++ W Sbjct: 717 ATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 770 >gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo sapiens] Length = 1248 Score = 89.7 bits (221), Expect = 4e-18 Identities = 87/337 (25%), Positives = 141/337 (41%), Gaps = 42/337 (12%) Query: 34 GRENWT--VAFAPDGSYFAWSQGHRTVKLVPWSQCLQN------------FLLHGTKNVT 79 G +W V F+PDGS F S +T++L + +N F + + Sbjct: 880 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 939 Query: 80 NSSSLRLPRQNSDGGQKNKPREHIIDC---GDIVWSLAFG-------------SSVPEKQ 123 RL N GQ + E + C + +AFG + + + + Sbjct: 940 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 999 Query: 124 SRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGS 183 + WH +F D+ L + ++ I++W+ K + L H E V+D + Sbjct: 1000 FQHKKTVWH-IQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSR 1057 Query: 184 LILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNM 243 L+ S S D T++VW++ GN K HQ V SC S D++ S A K +W+ Sbjct: 1058 LL--SWSFDGTVKVWNI-ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSF 1114 Query: 244 DKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTP 303 D + +L GH+ V FS D LLAT + + IW+ NG++L HL P + Sbjct: 1115 DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL----HLCAPLSE 1170 Query: 304 IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRI 340 A + WV + FS DG + S +++W + Sbjct: 1171 EGA-ATHGGWVTDLCFSPDGKMLISAGG--YIKWWNV 1204 Score = 84.0 bits (206), Expect = 2e-16 Identities = 66/249 (26%), Positives = 104/249 (41%), Gaps = 42/249 (16%) Query: 110 VWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDH 169 +W+ G V + F LLLATG ++ +K+WD+ + + H Sbjct: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742 Query: 170 TEVVRDLTFAPDGSLILVSASRDKTLRVWD------------------LKDDGNMMKVLR 211 T V F+PD L L S S D TL++WD L+D M+V+ Sbjct: 743 TNSVNHCRFSPDDKL-LASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI- 800 Query: 212 GHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLE-GHHHDVVACDFSPDGAL 270 V C++S D + + V A +FL+++ ++ ++ GHH + CDFSP L Sbjct: 801 -----VKCCSWSADGARI-MVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHL 854 Query: 271 LATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASL 329 A V +W+ + + + GHL WV V FS DG + Sbjct: 855 AVVALSQYCVELWNTDSRSKVADCRGHL--------------SWVHGVMFSPDGSSFLTS 900 Query: 330 ADDKMVRFW 338 +DD+ +R W Sbjct: 901 SDDQTIRLW 909 Score = 72.8 bits (177), Expect = 6e-13 Identities = 46/163 (28%), Positives = 79/163 (48%), Gaps = 15/163 (9%) Query: 135 RFGQDQLLLATGLNNGRIKIWDVYTG---------KLLLNLVDHTE----VVRDLTFAPD 181 RF D LLA+ +G +K+WD + + LNL D E +V+ +++ D Sbjct: 750 RFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSAD 809 Query: 182 GSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLW 241 G+ I+V+A + ++D+ G + ++ GH + + C FSP + + + V LW Sbjct: 810 GARIMVAAKNK--IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELW 867 Query: 242 NMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 284 N D + + GH V FSPDG+ T+S D + +W+ Sbjct: 868 NTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 910 Score = 65.5 bits (158), Expect = 9e-11 Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 17/174 (9%) Query: 209 VLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDG 268 V+R H + VY FS D + S GA K + ++ + + +++ H +V+ C FS D Sbjct: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669 Query: 269 ALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLH--V 326 +AT S D +V IW+ G+++ + + V F++ H + Sbjct: 670 RFIATCSVDKKVKIWNSMTGELVHTYDE-------------HSEQVNCCHFTNSSHHLLL 716 Query: 327 ASLADDKMVRFWRID--EDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378 A+ + D ++ W ++ E ++ C FS D +LA+ + DG++ W Sbjct: 717 ATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 770 Score = 64.7 bits (156), Expect = 2e-10 Identities = 57/214 (26%), Positives = 86/214 (40%), Gaps = 34/214 (15%) Query: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 228 HT+ V F+ DG I S DKTL+V+ + G + ++ H++ V CAFS D Sbjct: 614 HTDAVYHACFSEDGQRI-ASCGADKTLQVFKA-ETGEKLLEIKAHEDEVLCCAFSTDDRF 671 Query: 229 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDF--SPDGALLATASYDTRVYIWDPH 286 + + K V +WN ++ + H V C F S LLAT S D + +WD + Sbjct: 672 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 731 Query: 287 NGDIL-MEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW---RIDE 342 + FGH V FS D +AS + D ++ W +E Sbjct: 732 QKECRNTMFGH--------------TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE 777 Query: 343 DYPVQVAPLSNGL------------CCAFSTDGS 364 + V L CC++S DG+ Sbjct: 778 RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGA 811 Score = 44.7 bits (104), Expect = 2e-04 Identities = 26/96 (27%), Positives = 48/96 (50%), Gaps = 3/96 (3%) Query: 151 RIKIWDVYTGKLLLNL-VDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKV 209 +I ++D++T LL + H ++ F+P L +V+ S+ + +W+ D + + Sbjct: 820 KIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQ-YCVELWNT-DSRSKVAD 877 Query: 210 LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDK 245 RGH +WV+ FSPD S + + + LW K Sbjct: 878 CRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKK 913 >gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo sapiens] Length = 1194 Score = 89.7 bits (221), Expect = 4e-18 Identities = 87/337 (25%), Positives = 141/337 (41%), Gaps = 42/337 (12%) Query: 34 GRENWT--VAFAPDGSYFAWSQGHRTVKLVPWSQCLQN------------FLLHGTKNVT 79 G +W V F+PDGS F S +T++L + +N F + + Sbjct: 826 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 885 Query: 80 NSSSLRLPRQNSDGGQKNKPREHIIDC---GDIVWSLAFG-------------SSVPEKQ 123 RL N GQ + E + C + +AFG + + + + Sbjct: 886 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 945 Query: 124 SRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGS 183 + WH +F D+ L + ++ I++W+ K + L H E V+D + Sbjct: 946 FQHKKTVWH-IQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSR 1003 Query: 184 LILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNM 243 L+ S S D T++VW++ GN K HQ V SC S D++ S A K +W+ Sbjct: 1004 LL--SWSFDGTVKVWNI-ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSF 1060 Query: 244 DKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTP 303 D + +L GH+ V FS D LLAT + + IW+ NG++L HL P + Sbjct: 1061 DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL----HLCAPLSE 1116 Query: 304 IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRI 340 A + WV + FS DG + S +++W + Sbjct: 1117 EGA-ATHGGWVTDLCFSPDGKMLISAGG--YIKWWNV 1150 Score = 84.7 bits (208), Expect = 1e-16 Identities = 79/286 (27%), Positives = 124/286 (43%), Gaps = 43/286 (15%) Query: 76 KNVTNSSSLRLPRQNSDGGQK---NKPREHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWH 132 KN+TN S L + R ++D ++ + I CG F + EK + I+ H Sbjct: 590 KNITNLSRL-VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEK---LLEIKAH 645 Query: 133 RFR-----FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDG-SLIL 186 F D +AT + ++KIW+ TG+L+ +H+E V F L+L Sbjct: 646 EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLL 705 Query: 187 VSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLW----- 241 + S D L++WDL + + GH N V C FSPD +L S A + LW Sbjct: 706 ATGSSDCFLKLWDL-NQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSA 764 Query: 242 NMDKYTMIRK----LEGHHHD----VVACDFSPDGALLATASYDTRVYIWDPHNGDILME 293 N K +++ LE D V C +S DGA + A+ ++++W+ + + + Sbjct: 765 NERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSKVAD 823 Query: 294 F-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW 338 GHL WV V FS DG + +DD+ +R W Sbjct: 824 CRGHL--------------SWVHGVMFSPDGSSFLTSSDDQTIRLW 855 Score = 78.6 bits (192), Expect = 1e-14 Identities = 55/193 (28%), Positives = 83/193 (43%), Gaps = 26/193 (13%) Query: 110 VWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDH 169 +W+ G V + F LLLATG ++ +K+WD+ + + H Sbjct: 672 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 731 Query: 170 TEVVRDLTFAPDGSLILVSASRDKTLRVWD------------------LKDDGNMMKVLR 211 T V F+PD L L S S D TL++WD L+D M+V+ Sbjct: 732 TNSVNHCRFSPDDKL-LASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI- 789 Query: 212 GHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALL 271 V C++S D + + V A +FLWN D + + GH V FSPDG+ Sbjct: 790 -----VKCCSWSADGARIM-VAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 843 Query: 272 ATASYDTRVYIWD 284 T+S D + +W+ Sbjct: 844 LTSSDDQTIRLWE 856 Score = 71.2 bits (173), Expect = 2e-12 Identities = 69/284 (24%), Positives = 118/284 (41%), Gaps = 19/284 (6%) Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195 F +D +A+ + ++++ TG+ LL + H + V F+ D I + S DK + Sbjct: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFI-ATCSVDKKV 670 Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFL--WNMDKYTMIRKLE 253 ++W+ G ++ H V C F+ S L S FL W++++ + Sbjct: 671 KIWNSMT-GELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMF 729 Query: 254 GHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGD------ILMEFGHLFPPPTPIFAG 307 GH + V C FSPD LLA+ S D + +WD + + + F +L P + Sbjct: 730 GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM--- 786 Query: 308 GANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAP--LSNGLCCAFSTDGSV 365 + V+ S+S DG + A +K+ W D V LS FS DGS Sbjct: 787 ---EVIVKCCSWSADGARIMVAAKNKIF-LWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 842 Query: 366 LAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVMPTQEVQELPI 409 + D ++ W T + + + + + V EV L + Sbjct: 843 FLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAV 886 Score = 67.0 bits (162), Expect = 3e-11 Identities = 59/230 (25%), Positives = 92/230 (40%), Gaps = 35/230 (15%) Query: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 228 HT+ V F+ DG I S DKTL+V+ + G + ++ H++ V CAFS D Sbjct: 603 HTDAVYHACFSEDGQRI-ASCGADKTLQVFKA-ETGEKLLEIKAHEDEVLCCAFSTDDRF 660 Query: 229 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDF--SPDGALLATASYDTRVYIWDPH 286 + + K V +WN ++ + H V C F S LLAT S D + +WD + Sbjct: 661 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720 Query: 287 NGDIL-MEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW---RIDE 342 + FGH V FS D +AS + D ++ W +E Sbjct: 721 QKECRNTMFGH--------------TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE 766 Query: 343 DYPVQVAPLSNGL------------CCAFSTDGSVLAAGTHDGSVYFWAT 380 + V L CC++S DG+ + + ++ W T Sbjct: 767 RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN-KIFLWNT 815 Score = 65.5 bits (158), Expect = 9e-11 Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 17/174 (9%) Query: 209 VLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDG 268 V+R H + VY FS D + S GA K + ++ + + +++ H +V+ C FS D Sbjct: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658 Query: 269 ALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLH--V 326 +AT S D +V IW+ G+++ + + V F++ H + Sbjct: 659 RFIATCSVDKKVKIWNSMTGELVHTYDE-------------HSEQVNCCHFTNSSHHLLL 705 Query: 327 ASLADDKMVRFWRID--EDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378 A+ + D ++ W ++ E ++ C FS D +LA+ + DG++ W Sbjct: 706 ATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 759 >gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo sapiens] Length = 1237 Score = 89.7 bits (221), Expect = 4e-18 Identities = 87/337 (25%), Positives = 141/337 (41%), Gaps = 42/337 (12%) Query: 34 GRENWT--VAFAPDGSYFAWSQGHRTVKLVPWSQCLQN------------FLLHGTKNVT 79 G +W V F+PDGS F S +T++L + +N F + + Sbjct: 869 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 928 Query: 80 NSSSLRLPRQNSDGGQKNKPREHIIDC---GDIVWSLAFG-------------SSVPEKQ 123 RL N GQ + E + C + +AFG + + + + Sbjct: 929 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 988 Query: 124 SRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGS 183 + WH +F D+ L + ++ I++W+ K + L H E V+D + Sbjct: 989 FQHKKTVWH-IQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSR 1046 Query: 184 LILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNM 243 L+ S S D T++VW++ GN K HQ V SC S D++ S A K +W+ Sbjct: 1047 LL--SWSFDGTVKVWNI-ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSF 1103 Query: 244 DKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTP 303 D + +L GH+ V FS D LLAT + + IW+ NG++L HL P + Sbjct: 1104 DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL----HLCAPLSE 1159 Query: 304 IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRI 340 A + WV + FS DG + S +++W + Sbjct: 1160 EGA-ATHGGWVTDLCFSPDGKMLISAGG--YIKWWNV 1193 Score = 84.0 bits (206), Expect = 2e-16 Identities = 66/249 (26%), Positives = 104/249 (41%), Gaps = 42/249 (16%) Query: 110 VWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDH 169 +W+ G V + F LLLATG ++ +K+WD+ + + H Sbjct: 672 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 731 Query: 170 TEVVRDLTFAPDGSLILVSASRDKTLRVWD------------------LKDDGNMMKVLR 211 T V F+PD L L S S D TL++WD L+D M+V+ Sbjct: 732 TNSVNHCRFSPDDKL-LASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI- 789 Query: 212 GHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLE-GHHHDVVACDFSPDGAL 270 V C++S D + + V A +FL+++ ++ ++ GHH + CDFSP L Sbjct: 790 -----VKCCSWSADGARI-MVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHL 843 Query: 271 LATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASL 329 A V +W+ + + + GHL WV V FS DG + Sbjct: 844 AVVALSQYCVELWNTDSRSKVADCRGHL--------------SWVHGVMFSPDGSSFLTS 889 Query: 330 ADDKMVRFW 338 +DD+ +R W Sbjct: 890 SDDQTIRLW 898 Score = 72.8 bits (177), Expect = 6e-13 Identities = 46/163 (28%), Positives = 79/163 (48%), Gaps = 15/163 (9%) Query: 135 RFGQDQLLLATGLNNGRIKIWDVYTG---------KLLLNLVDHTE----VVRDLTFAPD 181 RF D LLA+ +G +K+WD + + LNL D E +V+ +++ D Sbjct: 739 RFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSAD 798 Query: 182 GSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLW 241 G+ I+V+A + ++D+ G + ++ GH + + C FSP + + + V LW Sbjct: 799 GARIMVAAKNK--IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELW 856 Query: 242 NMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 284 N D + + GH V FSPDG+ T+S D + +W+ Sbjct: 857 NTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 899 Score = 65.5 bits (158), Expect = 9e-11 Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 17/174 (9%) Query: 209 VLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDG 268 V+R H + VY FS D + S GA K + ++ + + +++ H +V+ C FS D Sbjct: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658 Query: 269 ALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLH--V 326 +AT S D +V IW+ G+++ + + V F++ H + Sbjct: 659 RFIATCSVDKKVKIWNSMTGELVHTYDE-------------HSEQVNCCHFTNSSHHLLL 705 Query: 327 ASLADDKMVRFWRID--EDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378 A+ + D ++ W ++ E ++ C FS D +LA+ + DG++ W Sbjct: 706 ATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 759 Score = 64.7 bits (156), Expect = 2e-10 Identities = 57/214 (26%), Positives = 86/214 (40%), Gaps = 34/214 (15%) Query: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 228 HT+ V F+ DG I S DKTL+V+ + G + ++ H++ V CAFS D Sbjct: 603 HTDAVYHACFSEDGQRI-ASCGADKTLQVFKA-ETGEKLLEIKAHEDEVLCCAFSTDDRF 660 Query: 229 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDF--SPDGALLATASYDTRVYIWDPH 286 + + K V +WN ++ + H V C F S LLAT S D + +WD + Sbjct: 661 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720 Query: 287 NGDIL-MEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW---RIDE 342 + FGH V FS D +AS + D ++ W +E Sbjct: 721 QKECRNTMFGH--------------TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE 766 Query: 343 DYPVQVAPLSNGL------------CCAFSTDGS 364 + V L CC++S DG+ Sbjct: 767 RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGA 800 Score = 44.7 bits (104), Expect = 2e-04 Identities = 26/96 (27%), Positives = 48/96 (50%), Gaps = 3/96 (3%) Query: 151 RIKIWDVYTGKLLLNL-VDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKV 209 +I ++D++T LL + H ++ F+P L +V+ S+ + +W+ D + + Sbjct: 809 KIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQ-YCVELWNT-DSRSKVAD 866 Query: 210 LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDK 245 RGH +WV+ FSPD S + + + LW K Sbjct: 867 CRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKK 902 >gi|21071067 TBP-associated factor 5 [Homo sapiens] Length = 800 Score = 89.0 bits (219), Expect = 7e-18 Identities = 78/271 (28%), Positives = 114/271 (42%), Gaps = 44/271 (16%) Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198 D L+A G + +++W V KL R + A D SLI S D R+ Sbjct: 481 DSSLIAGGFADSTVRVWSVTPKKL-----------RSVKQASDLSLI-DKESDDVLERIM 528 Query: 199 DLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHD 258 D K + +K+L GH VY +FSPD + L S V LW++ +T + +GH++ Sbjct: 529 DEKT-ASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYP 587 Query: 259 VVACDFSPDGALLATASYDTRVYIW-DPHNGDILMEFGHL-------FPPPTPIFAGGAN 310 V FSP G + +D +W H + + GHL F P + A G+ Sbjct: 588 VWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSA 647 Query: 311 DRWVR---------------------SVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVA 349 DR VR S++FS +G +A+ A D V W I V Sbjct: 648 DRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL 707 Query: 350 PLSNGLCCA--FSTDGSVLAAGTHDGSVYFW 378 C+ FS DG +LA+G+ D +V W Sbjct: 708 KGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738 Score = 85.5 bits (210), Expect = 8e-17 Identities = 60/204 (29%), Positives = 93/204 (45%), Gaps = 17/204 (8%) Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195 F D+ L + +G +++W + T L+ H V D F+P G VS D+ Sbjct: 551 FSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYG-YYFVSGGHDRVA 609 Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255 R+W D +++ GH V F P+S+ + + A + V LW++ +R GH Sbjct: 610 RLW-ATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGH 668 Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWV 314 + + FSP+G LAT + D RV +WD +G ++ E GH V Sbjct: 669 KGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGH--------------TDTV 714 Query: 315 RSVSFSHDGLHVASLADDKMVRFW 338 S+ FS DG +AS + D VR W Sbjct: 715 CSLRFSRDGEILASGSMDNTVRLW 738 Score = 60.1 bits (144), Expect = 4e-09 Identities = 35/111 (31%), Positives = 55/111 (49%), Gaps = 2/111 (1%) Query: 135 RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKT 194 RF + +ATG + +++WDV G + H + LTF+P+G + A+ + Sbjct: 634 RFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRV 693 Query: 195 LRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDK 245 L +WD+ G M+ L+GH + V S FS D +L S V LW+ K Sbjct: 694 L-LWDI-GHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIK 742 Score = 56.2 bits (134), Expect = 5e-08 Identities = 28/68 (41%), Positives = 39/68 (57%), Gaps = 1/68 (1%) Query: 132 HRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASR 191 H F + LATG +GR+ +WD+ G ++ L HT+ V L F+ DG IL S S Sbjct: 673 HSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGE-ILASGSM 731 Query: 192 DKTLRVWD 199 D T+R+WD Sbjct: 732 DNTVRLWD 739 Score = 30.8 bits (68), Expect = 2.4 Identities = 39/170 (22%), Positives = 57/170 (33%), Gaps = 44/170 (25%) Query: 246 YTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIW-------------------DPH 286 YT + +G + A D + D +L+A D+ V +W D Sbjct: 464 YTFLNAYQG----LTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKE 519 Query: 287 NGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRID---- 341 + D+L I G + V SFS D ++ S ++D VR W + Sbjct: 520 SDDVLERIMDEKTASELKILYGHSGP--VYGASFSPDRNYLLSSSEDGTVRLWSLQTFTC 577 Query: 342 ------EDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVP 385 +YPV FS G +G HD WAT P Sbjct: 578 LVGYKGHNYPVWDTQ--------FSPYGYYFVSGGHDRVARLWATDHYQP 619 Score = 30.4 bits (67), Expect = 3.1 Identities = 34/160 (21%), Positives = 61/160 (38%), Gaps = 18/160 (11%) Query: 42 FAPDGSYFAWSQGHRTVKL--VPWSQCLQNFLLHG--TKNVTNSSSLRLPRQNSDGGQKN 97 F P+ +Y A RTV+L V C++ F H ++T S + R + G+ Sbjct: 635 FHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRV- 693 Query: 98 KPREHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDV 157 ++W + G V E + + RF +D +LA+G + +++WD Sbjct: 694 -----------LLWDIGHGLMVGELKGHTDTV--CSLRFSRDGEILASGSMDNTVRLWDA 740 Query: 158 YTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRV 197 L D T + + +L+ K+ V Sbjct: 741 IKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPV 780 >gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit [Homo sapiens] Length = 410 Score = 88.6 bits (218), Expect = 1e-17 Identities = 54/174 (31%), Positives = 84/174 (48%), Gaps = 17/174 (9%) Query: 166 LVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPD 225 L H V + F P S ++VSAS D T++VWD + G+ + L+GH + V +F Sbjct: 104 LSGHRSPVTRVIFHPVFS-VMVSASEDATIKVWDY-ETGDFERTLKGHTDSVQDISFDHS 161 Query: 226 SSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDP 285 +L S A + LW+ + IR + GH H+V + P+G + +AS D + +W+ Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEV 221 Query: 286 HNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW 338 G + F GH WVR V + DG +AS ++D+ VR W Sbjct: 222 QTGYCVKTFTGH--------------REWVRMVRPNQDGTLIASCSNDQTVRVW 261 Score = 85.1 bits (209), Expect = 1e-16 Identities = 62/224 (27%), Positives = 94/224 (41%), Gaps = 37/224 (16%) Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195 F LLA+ + IK+WD + + + H V + P+G I VSASRDKT+ Sbjct: 158 FDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHI-VSASRDKTI 216 Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255 ++W+++ G +K GH+ WV + D +++ S + V +W + +L H Sbjct: 217 KMWEVQT-GYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREH 275 Query: 256 HHDVVACDFSPD--------------------GALLATASYDTRVYIWDPHNGDILMEF- 294 H V ++P+ G L + S D + +WD G LM Sbjct: 276 EHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLV 335 Query: 295 GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW 338 GH D WVR V F G + S ADDK +R W Sbjct: 336 GH--------------DNWVRGVLFHSGGKFILSCADDKTLRVW 365 Score = 83.2 bits (204), Expect = 4e-16 Identities = 50/175 (28%), Positives = 78/175 (44%), Gaps = 21/175 (12%) Query: 130 EWHRF-RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSL---- 184 EW R R QD L+A+ N+ +++W V T + L +H VV +++AP+ S Sbjct: 235 EWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSIS 294 Query: 185 ---------------ILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSML 229 L+S SRDKT+++WD+ G + L GH NWV F + Sbjct: 295 EATGSETKKSGKPGPFLLSGSRDKTIKMWDVST-GMCLMTLVGHDNWVRGVLFHSGGKFI 353 Query: 230 CSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 284 S K + +W+ ++ L H H V + DF + T S D V +W+ Sbjct: 354 LSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408 Score = 59.3 bits (142), Expect = 6e-09 Identities = 43/172 (25%), Positives = 73/172 (42%), Gaps = 17/172 (9%) Query: 210 LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGA 269 L GH++ V F P S++ S + +W+ + R L+GH V F G Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163 Query: 270 LLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVAS 328 LLA+ S D + +WD + + GH D V SV+ +G H+ S Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGH--------------DHNVSSVAIMPNGDHIVS 209 Query: 329 LADDKMVRFWRIDEDYPVQVAPLSNGLCCAF--STDGSVLAAGTHDGSVYFW 378 + DK ++ W + Y V+ + DG+++A+ ++D +V W Sbjct: 210 ASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 261 Score = 58.5 bits (140), Expect = 1e-08 Identities = 50/207 (24%), Positives = 85/207 (41%), Gaps = 35/207 (16%) Query: 152 IKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLR 211 IK+W+V TG + H E VR + DG+LI S S D+T+RVW + LR Sbjct: 216 IKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLI-ASCSNDQTVRVWVVATK-ECKAELR 273 Query: 212 GHQNWVYSCAFSPDSS--------------------MLCSVGASKAVFLWNMDKYTMIRK 251 H++ V +++P+SS L S K + +W++ + Sbjct: 274 EHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMT 333 Query: 252 LEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGAND 311 L GH + V F G + + + D + +WD N + A++ Sbjct: 334 LVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTL-------------NAHE 380 Query: 312 RWVRSVSFSHDGLHVASLADDKMVRFW 338 +V S+ F +V + + D+ V+ W Sbjct: 381 HFVTSLDFHKTAPYVVTGSVDQTVKVW 407 >gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] Length = 589 Score = 87.8 bits (216), Expect = 2e-17 Identities = 48/147 (32%), Positives = 78/147 (53%), Gaps = 2/147 (1%) Query: 141 LLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDL 200 L A+G ++ ++W L H V + F P+ + L + S DKT+R+W Sbjct: 397 LYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNY-LATGSTDKTVRLWSA 455 Query: 201 KDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVV 260 + GN +++ GH+ V S AFSP+ L S G + + LW++ T+ ++L GH ++ Sbjct: 456 QQ-GNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNIT 514 Query: 261 ACDFSPDGALLATASYDTRVYIWDPHN 287 + FSPD L+A+AS D V +WD N Sbjct: 515 SLTFSPDSGLIASASMDNSVRVWDIRN 541 Score = 83.2 bits (204), Expect = 4e-16 Identities = 75/273 (27%), Positives = 111/273 (40%), Gaps = 47/273 (17%) Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198 D LLA G +N IK+W + + KL H V + A D L Sbjct: 279 DSKLLAAGFDNSCIKLWSLRSKKLKSE--PHQVDVSRIHLACD------------ILEEE 324 Query: 199 DLKDD--GNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHH 256 D +DD G MK+LRGH VYS F DSS L S ++ W++ +T +GH Sbjct: 325 DDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHA 384 Query: 257 HDVVACDFSPDGALLATASYDTRVYIWD-PHNGDILMEFGHL-------FPPPTPIFAGG 308 + V D SP A+ S+D +W + + GHL F P + A G Sbjct: 385 YPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATG 444 Query: 309 ANDRWVR---------------------SVSFSHDGLHVASLADDKMVRFWRIDED--YP 345 + D+ VR S++FS +G ++AS +D+ ++ W + Y Sbjct: 445 STDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYK 504 Query: 346 VQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378 N FS D ++A+ + D SV W Sbjct: 505 ELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537 Score = 83.2 bits (204), Expect = 4e-16 Identities = 63/210 (30%), Positives = 94/210 (44%), Gaps = 15/210 (7%) Query: 135 RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKT 194 RF D L + + I+ WD+ + + H V DL +P SL S S D+T Sbjct: 349 RFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPY-SLYFASGSHDRT 407 Query: 195 LRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEG 254 R+W D +++ GH V F P+S+ L + K V LW+ + +R G Sbjct: 408 ARLWSF-DRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTG 466 Query: 255 HHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWV 314 H V++ FSP+G LA+A D R+ +WD +G + E G D + Sbjct: 467 HRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL------------RGHTDN-I 513 Query: 315 RSVSFSHDGLHVASLADDKMVRFWRIDEDY 344 S++FS D +AS + D VR W I Y Sbjct: 514 TSLTFSPDSGLIASASMDNSVRVWDIRNTY 543 >gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] Length = 369 Score = 86.3 bits (212), Expect = 5e-17 Identities = 62/209 (29%), Positives = 93/209 (44%), Gaps = 17/209 (8%) Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195 F D T ++ +K+W + K L +L H VR F+PDG LI VSAS DKT+ Sbjct: 73 FCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLI-VSASDDKTV 131 Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255 ++WD K + H +V F P + + + G V +W++ + +++ + H Sbjct: 132 KLWD-KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLH 190 Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWV 314 V F P G L TAS D+ + I D G +L GH P T Sbjct: 191 SAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATT------------ 238 Query: 315 RSVSFSHDGLHVASLADDKMVRFWRIDED 343 V+FS G + AS D+ V W+ + D Sbjct: 239 --VAFSRTGEYFASGGSDEQVMVWKSNFD 265 Score = 82.0 bits (201), Expect = 9e-16 Identities = 69/263 (26%), Positives = 98/263 (37%), Gaps = 22/263 (8%) Query: 123 QSRCVNIEWHR-----FRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLT 177 QSR H+ F LLA+G + ++IW HT VR + Sbjct: 13 QSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVH 72 Query: 178 FAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKA 237 F DG V+AS DKT++VW + L H NWV FSPD ++ S K Sbjct: 73 FCSDGQSF-VTASDDKTVKVWATHRQKFLFS-LSQHINWVRCAKFSPDGRLIVSASDDKT 130 Query: 238 VFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHL 297 V LW+ + H V DF P G +A A D V +WD +L + Sbjct: 131 VKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY--- 187 Query: 298 FPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--L 355 + V +SF G ++ + + D ++ + E + G Sbjct: 188 ----------QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 237 Query: 356 CCAFSTDGSVLAAGTHDGSVYFW 378 AFS G A+G D V W Sbjct: 238 TVAFSRTGEYFASGGSDEQVMVW 260 Score = 60.8 bits (146), Expect = 2e-09 Identities = 42/143 (29%), Positives = 66/143 (46%), Gaps = 15/143 (10%) Query: 238 VFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHL 297 + +W+M + + GH V +FSP G LLA+ S D V IW P+ Sbjct: 5 LMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPN----------- 53 Query: 298 FPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRID-EDYPVQVAPLSNGLC 356 + +F A+ VRSV F DG + +DDK V+ W + + ++ N + Sbjct: 54 VKGESTVFR--AHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVR 111 Query: 357 CA-FSTDGSVLAAGTHDGSVYFW 378 CA FS DG ++ + + D +V W Sbjct: 112 CAKFSPDGRLIVSASDDKTVKLW 134 Score = 33.9 bits (76), Expect = 0.28 Identities = 24/72 (33%), Positives = 33/72 (45%), Gaps = 2/72 (2%) Query: 314 VRSVSFSHDGLHVASLADDKMVRFW--RIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTH 371 V V+FS G +AS + DK VR W + + V A + F +DG + Sbjct: 26 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 85 Query: 372 DGSVYFWATPRQ 383 D +V WAT RQ Sbjct: 86 DKTVKVWATHRQ 97 >gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] Length = 359 Score = 86.3 bits (212), Expect = 5e-17 Identities = 62/209 (29%), Positives = 93/209 (44%), Gaps = 17/209 (8%) Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195 F D T ++ +K+W + K L +L H VR F+PDG LI VSAS DKT+ Sbjct: 111 FCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLI-VSASDDKTV 169 Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255 ++WD K + H +V F P + + + G V +W++ + +++ + H Sbjct: 170 KLWD-KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLH 228 Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWV 314 V F P G L TAS D+ + I D G +L GH P T Sbjct: 229 SAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATT------------ 276 Query: 315 RSVSFSHDGLHVASLADDKMVRFWRIDED 343 V+FS G + AS D+ V W+ + D Sbjct: 277 --VAFSRTGEYFASGGSDEQVMVWKSNFD 303 Score = 82.0 bits (201), Expect = 9e-16 Identities = 69/263 (26%), Positives = 98/263 (37%), Gaps = 22/263 (8%) Query: 123 QSRCVNIEWHR-----FRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLT 177 QSR H+ F LLA+G + ++IW HT VR + Sbjct: 51 QSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVH 110 Query: 178 FAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKA 237 F DG V+AS DKT++VW + L H NWV FSPD ++ S K Sbjct: 111 FCSDGQSF-VTASDDKTVKVWATHRQKFLFS-LSQHINWVRCAKFSPDGRLIVSASDDKT 168 Query: 238 VFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHL 297 V LW+ + H V DF P G +A A D V +WD +L + Sbjct: 169 VKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY--- 225 Query: 298 FPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--L 355 + V +SF G ++ + + D ++ + E + G Sbjct: 226 ----------QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 275 Query: 356 CCAFSTDGSVLAAGTHDGSVYFW 378 AFS G A+G D V W Sbjct: 276 TVAFSRTGEYFASGGSDEQVMVW 298 Score = 78.6 bits (192), Expect = 1e-14 Identities = 65/238 (27%), Positives = 100/238 (42%), Gaps = 23/238 (9%) Query: 143 LATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKD 202 LA+G + + +W + H + V + F+P G L L S SRDKT+R+W Sbjct: 34 LASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL-LASGSRDKTVRIWVPNV 92 Query: 203 DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVAC 262 G V R H V S F D + K V +W + + L H + V Sbjct: 93 KGE-STVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCA 151 Query: 263 DFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHD 322 FSPDG L+ +AS D V +WD + + + + GG +V V F Sbjct: 152 KFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE---------HGG----FVTYVDFHPS 198 Query: 323 GLHVASLADDKMVRFW-----RIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSV 375 G +A+ D V+ W R+ + Y + A + NGL +F G+ L + D ++ Sbjct: 199 GTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAV-NGL--SFHPSGNYLITASSDSTL 253 Score = 73.2 bits (178), Expect = 4e-13 Identities = 50/179 (27%), Positives = 83/179 (46%), Gaps = 15/179 (8%) Query: 202 DDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVA 261 +D ++ + +GH++ V FS ++ L S + +W+M + + GH V Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66 Query: 262 CDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSH 321 +FSP G LLA+ S D V IW P+ + +F A+ VRSV F Sbjct: 67 VNFSPSGHLLASGSRDKTVRIWVPN-----------VKGESTVFR--AHTATVRSVHFCS 113 Query: 322 DGLHVASLADDKMVRFWRID-EDYPVQVAPLSNGLCCA-FSTDGSVLAAGTHDGSVYFW 378 DG + +DDK V+ W + + ++ N + CA FS DG ++ + + D +V W Sbjct: 114 DGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172 Score = 47.0 bits (110), Expect = 3e-05 Identities = 40/136 (29%), Positives = 56/136 (41%), Gaps = 15/136 (11%) Query: 250 RKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGA 309 R +GH V DFS + LA+ S D+ + +W H+ P G Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVW------------HMKPQSRAYRFTGH 60 Query: 310 NDRWVRSVSFSHDGLHVASLADDKMVRFW--RIDEDYPVQVAPLSNGLCCAFSTDGSVLA 367 D V V+FS G +AS + DK VR W + + V A + F +DG Sbjct: 61 KDA-VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 119 Query: 368 AGTHDGSVYFWATPRQ 383 + D +V WAT RQ Sbjct: 120 TASDDKTVKVWATHRQ 135 >gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] Length = 407 Score = 86.3 bits (212), Expect = 5e-17 Identities = 62/209 (29%), Positives = 93/209 (44%), Gaps = 17/209 (8%) Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195 F D T ++ +K+W + K L +L H VR F+PDG LI VSAS DKT+ Sbjct: 111 FCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLI-VSASDDKTV 169 Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255 ++WD K + H +V F P + + + G V +W++ + +++ + H Sbjct: 170 KLWD-KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLH 228 Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWV 314 V F P G L TAS D+ + I D G +L GH P T Sbjct: 229 SAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATT------------ 276 Query: 315 RSVSFSHDGLHVASLADDKMVRFWRIDED 343 V+FS G + AS D+ V W+ + D Sbjct: 277 --VAFSRTGEYFASGGSDEQVMVWKSNFD 303 Score = 82.0 bits (201), Expect = 9e-16 Identities = 69/263 (26%), Positives = 98/263 (37%), Gaps = 22/263 (8%) Query: 123 QSRCVNIEWHR-----FRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLT 177 QSR H+ F LLA+G + ++IW HT VR + Sbjct: 51 QSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVH 110 Query: 178 FAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKA 237 F DG V+AS DKT++VW + L H NWV FSPD ++ S K Sbjct: 111 FCSDGQSF-VTASDDKTVKVWATHRQKFLFS-LSQHINWVRCAKFSPDGRLIVSASDDKT 168 Query: 238 VFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHL 297 V LW+ + H V DF P G +A A D V +WD +L + Sbjct: 169 VKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY--- 225 Query: 298 FPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--L 355 + V +SF G ++ + + D ++ + E + G Sbjct: 226 ----------QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 275 Query: 356 CCAFSTDGSVLAAGTHDGSVYFW 378 AFS G A+G D V W Sbjct: 276 TVAFSRTGEYFASGGSDEQVMVW 298 Score = 78.6 bits (192), Expect = 1e-14 Identities = 65/238 (27%), Positives = 100/238 (42%), Gaps = 23/238 (9%) Query: 143 LATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKD 202 LA+G + + +W + H + V + F+P G L L S SRDKT+R+W Sbjct: 34 LASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL-LASGSRDKTVRIWVPNV 92 Query: 203 DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVAC 262 G V R H V S F D + K V +W + + L H + V Sbjct: 93 KGE-STVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCA 151 Query: 263 DFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHD 322 FSPDG L+ +AS D V +WD + + + + GG +V V F Sbjct: 152 KFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE---------HGG----FVTYVDFHPS 198 Query: 323 GLHVASLADDKMVRFW-----RIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSV 375 G +A+ D V+ W R+ + Y + A + NGL +F G+ L + D ++ Sbjct: 199 GTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAV-NGL--SFHPSGNYLITASSDSTL 253 Score = 73.2 bits (178), Expect = 4e-13 Identities = 50/179 (27%), Positives = 83/179 (46%), Gaps = 15/179 (8%) Query: 202 DDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVA 261 +D ++ + +GH++ V FS ++ L S + +W+M + + GH V Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66 Query: 262 CDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSH 321 +FSP G LLA+ S D V IW P+ + +F A+ VRSV F Sbjct: 67 VNFSPSGHLLASGSRDKTVRIWVPN-----------VKGESTVFR--AHTATVRSVHFCS 113 Query: 322 DGLHVASLADDKMVRFWRID-EDYPVQVAPLSNGLCCA-FSTDGSVLAAGTHDGSVYFW 378 DG + +DDK V+ W + + ++ N + CA FS DG ++ + + D +V W Sbjct: 114 DGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172 Score = 47.0 bits (110), Expect = 3e-05 Identities = 40/136 (29%), Positives = 56/136 (41%), Gaps = 15/136 (11%) Query: 250 RKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGA 309 R +GH V DFS + LA+ S D+ + +W H+ P G Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVW------------HMKPQSRAYRFTGH 60 Query: 310 NDRWVRSVSFSHDGLHVASLADDKMVRFW--RIDEDYPVQVAPLSNGLCCAFSTDGSVLA 367 D V V+FS G +AS + DK VR W + + V A + F +DG Sbjct: 61 KDA-VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 119 Query: 368 AGTHDGSVYFWATPRQ 383 + D +V WAT RQ Sbjct: 120 TASDDKTVKVWATHRQ 135 >gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] Length = 357 Score = 83.6 bits (205), Expect = 3e-16 Identities = 71/241 (29%), Positives = 109/241 (45%), Gaps = 28/241 (11%) Query: 152 IKIWDVYTG-KLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVL 210 I +W+VY L H+ V +L + DGS+ L SAS DKT+ VWD + G +K L Sbjct: 90 ILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM-LFSASTDKTVAVWD-SETGERVKRL 147 Query: 211 RGHQNWVYSCAFSPDSSMLCSVGASKA-VFLWNMDKYTMIRKLEGHHHDVVACDFSPDGA 269 +GH ++V SC + L G+ V LW++ K I+ + + + V+A F+ Sbjct: 148 KGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSD 206 Query: 270 LLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASL 329 + + D + +WD + T G A+ V +S S +G ++ S Sbjct: 207 QIISGGIDNDIKVWDLRQNKL-----------TYTMRGHADS--VTGLSLSSEGSYLLSN 253 Query: 330 ADDKMVRFWRIDEDYPVQVAPL----------SNGLCCAFSTDGSVLAAGTHDGSVYFWA 379 A D VR W + P + N L C++S DGS +AAG+ D VY W Sbjct: 254 AMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWD 313 Query: 380 T 380 T Sbjct: 314 T 314 Score = 77.4 bits (189), Expect = 2e-14 Identities = 43/148 (29%), Positives = 81/148 (54%), Gaps = 9/148 (6%) Query: 142 LLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLK 201 +++ G++N IK+WD+ KL + H + V L+ + +GS +L +A D T+RVWD++ Sbjct: 208 IISGGIDND-IKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAM-DNTVRVWDVR 265 Query: 202 DDGNMMKVLRGHQNWVYS-------CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEG 254 + ++ Q V++ C++SPD S + + A + V++W+ ++ KL G Sbjct: 266 PFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPG 325 Query: 255 HHHDVVACDFSPDGALLATASYDTRVYI 282 H + F PD ++ +AS D R+Y+ Sbjct: 326 HAGSINEVAFHPDEPIIISASSDKRLYM 353 Score = 67.8 bits (164), Expect = 2e-11 Identities = 55/251 (21%), Positives = 104/251 (41%), Gaps = 25/251 (9%) Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195 + D +L + + + +WD TG+ + L HT V A G ++ + S D T+ Sbjct: 117 YNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTV 176 Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255 ++WD++ + +Q V + F+ S + S G + +W++ + + + GH Sbjct: 177 KLWDIRKKAAIQTFQNTYQ--VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGH 234 Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPP---TPIFAGGAN-- 310 V S +G+ L + + D V +WD F P IF G + Sbjct: 235 ADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRP----------FAPKERCVKIFQGNVHNF 284 Query: 311 DRWVRSVSFSHDGLHVASLADDKMVRFW-----RIDEDYPVQVAPLSNGLCCAFSTDGSV 365 ++ + S+S DG +A+ + D+ V W RI P ++ AF D + Sbjct: 285 EKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINE---VAFHPDEPI 341 Query: 366 LAAGTHDGSVY 376 + + + D +Y Sbjct: 342 IISASSDKRLY 352 Score = 35.4 bits (80), Expect = 0.098 Identities = 19/69 (27%), Positives = 36/69 (52%), Gaps = 1/69 (1%) Query: 133 RFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRD 192 R + D +A G + + +WD + ++L L H + ++ F PD I++SAS D Sbjct: 290 RCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPD-EPIIISASSD 348 Query: 193 KTLRVWDLK 201 K L + +++ Sbjct: 349 KRLYMGEIQ 357 >gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [Homo sapiens] Length = 340 Score = 83.2 bits (204), Expect = 4e-16 Identities = 65/256 (25%), Positives = 110/256 (42%), Gaps = 22/256 (8%) Query: 132 HRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASR 191 + +G D LL + +G++ IWD YT + + + V +AP G+ + Sbjct: 59 YAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYV-ACGGL 117 Query: 192 DKTLRVWDLKD-DGN--MMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTM 248 D +++LK +GN + + L GH ++ C F DS ++ S G + LW+++ Sbjct: 118 DNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCA-LWDIETAQQ 176 Query: 249 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGG 308 GH DV++ SPD + + D +WD +G F G Sbjct: 177 TTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQS-----------FTGH 225 Query: 309 ANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLC----CAFSTDGS 364 +D + +VSF +G A+ +DD R + + D + + N +C AFS G Sbjct: 226 VSD--INAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGR 283 Query: 365 VLAAGTHDGSVYFWAT 380 +L AG D + W T Sbjct: 284 LLLAGYDDFNCNVWDT 299 Score = 55.1 bits (131), Expect = 1e-07 Identities = 39/149 (26%), Positives = 66/149 (44%), Gaps = 6/149 (4%) Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198 D +G + K+WD+ G + H + ++F P+G + S D T R++ Sbjct: 195 DMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNG-YAFATGSDDATCRLF 253 Query: 199 DLKDDGNMMKVLRGHQN---WVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255 DL+ D ++ L H N + S AFS +L + +W+ K L GH Sbjct: 254 DLRADQELL--LYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGH 311 Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWD 284 + V + DG +AT S+D+ + IW+ Sbjct: 312 DNRVSCLGVTDDGMAVATGSWDSFLRIWN 340 Score = 37.7 bits (86), Expect = 0.020 Identities = 34/141 (24%), Positives = 54/141 (38%), Gaps = 30/141 (21%) Query: 242 NMDKYTMI-----RKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGH 296 NMD I R L GH + A + D LL +AS D ++ IWD + + + H Sbjct: 36 NMDSVGRIQMRTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKM----H 91 Query: 297 LFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW---------RIDEDYPVQ 347 P WV + +++ G +VA D + + R+ + P Sbjct: 92 AIP---------LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGH 142 Query: 348 VAPLSNGLCCAFSTDGSVLAA 368 LS CC F D ++ + Sbjct: 143 TGYLS---CCRFLDDSQIVTS 160 Score = 29.6 bits (65), Expect = 5.4 Identities = 18/64 (28%), Positives = 27/64 (42%), Gaps = 1/64 (1%) Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195 F + LL G ++ +WD G L H V L DG + + + S D L Sbjct: 278 FSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDG-MAVATGSWDSFL 336 Query: 196 RVWD 199 R+W+ Sbjct: 337 RIWN 340 >gi|5803221 WD repeat-containing protein 3 [Homo sapiens] Length = 943 Score = 81.6 bits (200), Expect = 1e-15 Identities = 48/158 (30%), Positives = 82/158 (51%), Gaps = 2/158 (1%) Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195 + +Q LLA L + +KI+ V T K L+L H V + + DG+LI + S D+ + Sbjct: 557 YSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALI-ATGSADRNV 615 Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255 ++W L D G+ K L H + V F P S + + G + W+ DK+ I+ LEGH Sbjct: 616 KIWGL-DFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGH 674 Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILME 293 H ++ SP G + ++S+D + +W+ +++E Sbjct: 675 HQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILE 712 Score = 72.8 bits (177), Expect = 6e-13 Identities = 62/250 (24%), Positives = 106/250 (42%), Gaps = 26/250 (10%) Query: 146 GLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWD---LKD 202 G G+++++D+ +G LL + H + ++ +PD V+ DK+++ WD +KD Sbjct: 472 GTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPD-QRGFVTGGADKSVKFWDFELVKD 530 Query: 203 DGNMMKVLRGHQNW-------VYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255 + + K L Q V ++SP+ +L V ++ +D L GH Sbjct: 531 ENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGH 590 Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVR 315 V+ D S DGAL+AT S D V IW GD +FA + +++ Sbjct: 591 KLPVICMDISHDGALIATGSADRNVKIWGLDFGDC----------HKSLFAHDDSVMYLQ 640 Query: 316 SVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDG 373 V SH + D ++ W D+ +Q + C A S G + + +HD Sbjct: 641 FVPKSH---LFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDK 697 Query: 374 SVYFWATPRQ 383 S+ W R+ Sbjct: 698 SLRLWERTRE 707 Score = 60.5 bits (145), Expect = 3e-09 Identities = 36/146 (24%), Positives = 70/146 (47%), Gaps = 2/146 (1%) Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198 D L LA G +G I+I+ + +G+ + H + L + G L S S+D + VW Sbjct: 76 DGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGR-LASGSKDTDIIVW 134 Query: 199 DLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHD 258 D+ ++ + + L+GH++ + F + ++L + G V W++D + + GH + Sbjct: 135 DVINESGLYR-LKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTE 193 Query: 259 VVACDFSPDGALLATASYDTRVYIWD 284 V + L T + D+ + +WD Sbjct: 194 VWGLVLLSEEKRLITGASDSELRVWD 219 Score = 52.4 bits (124), Expect = 8e-07 Identities = 33/115 (28%), Positives = 53/115 (46%), Gaps = 2/115 (1%) Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198 D L+ATG + +KIW + G +L H + V L F P L +A +D ++ W Sbjct: 602 DGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFF-TAGKDHKIKQW 660 Query: 199 DLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLE 253 D D ++ L GH ++ A SP + S K++ LW + +I + E Sbjct: 661 DA-DKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILEEE 714 Score = 47.8 bits (112), Expect = 2e-05 Identities = 35/132 (26%), Positives = 61/132 (46%), Gaps = 4/132 (3%) Query: 154 IWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWD-LKDDGNMMKVLRG 212 IWD+ G+ +L L + V L +PDG L L D ++R++ L +GN+ G Sbjct: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDG-LHLAVGYEDGSIRIFSLLSGEGNV--TFNG 105 Query: 213 HQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLA 272 H+ + + + L S + +W++ + + +L+GH + F + LL Sbjct: 106 HKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLV 165 Query: 273 TASYDTRVYIWD 284 T+ DT V WD Sbjct: 166 TSGKDTMVKWWD 177 Score = 42.0 bits (97), Expect = 0.001 Identities = 25/101 (24%), Positives = 48/101 (47%), Gaps = 2/101 (1%) Query: 143 LATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKD 202 LA+G + I +WDV L L H + + F + +L LV++ +D ++ WDL D Sbjct: 122 LASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNL-LVTSGKDTMVKWWDL-D 179 Query: 203 DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNM 243 + K + GH+ V+ + L + + + +W++ Sbjct: 180 TQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220 Score = 35.4 bits (80), Expect = 0.098 Identities = 33/148 (22%), Positives = 57/148 (38%), Gaps = 14/148 (9%) Query: 197 VWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHH 256 +WDL+ G + +L+G + V SPD L ++ ++++ GH Sbjct: 49 IWDLRK-GEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHK 107 Query: 257 HDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRS 316 + + G LA+ S DT + +WD N L G D ++ Sbjct: 108 AAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRL------------KGHKDAITQA 155 Query: 317 VSFSHDGLHVASLADDKMVRFWRIDEDY 344 + L V S D MV++W +D + Sbjct: 156 LFLREKNLLVTS-GKDTMVKWWDLDTQH 182 Score = 33.5 bits (75), Expect = 0.37 Identities = 20/65 (30%), Positives = 31/65 (47%), Gaps = 1/65 (1%) Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195 F +++ LL T + +K WD+ T +V H V L + ++ AS D L Sbjct: 157 FLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGAS-DSEL 215 Query: 196 RVWDL 200 RVWD+ Sbjct: 216 RVWDI 220 Score = 31.6 bits (70), Expect = 1.4 Identities = 22/67 (32%), Positives = 34/67 (50%), Gaps = 1/67 (1%) Query: 231 SVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDI 290 +V A + VF+W++ K I L+G +V SPDG LA D + I+ +G+ Sbjct: 40 AVPACEHVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEG 99 Query: 291 LMEF-GH 296 + F GH Sbjct: 100 NVTFNGH 106 >gi|48928050 F-box and WD repeat domain containing 11 isoform C [Homo sapiens] Length = 542 Score = 81.3 bits (199), Expect = 2e-15 Identities = 65/270 (24%), Positives = 114/270 (42%), Gaps = 35/270 (12%) Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198 D+ ++ TG ++ +++WDV TG++L L+ H E V L F+ + ++V+ S+D+++ VW Sbjct: 289 DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS---NGLMVTCSKDRSIAVW 345 Query: 199 DLKD--DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHH 256 D+ D + +VL GH+ V F D + S + + +W+ +R L GH Sbjct: 346 DMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHK 403 Query: 257 HDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVR 315 + + L+ + S D + +WD G L GH + VR Sbjct: 404 RGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGH--------------EELVR 447 Query: 316 SVSFSHDGLHVASLADDKMVRFW----RIDEDYPVQVAPL-----SNGLCCAFSTDGSVL 366 + F D + S A D ++ W +D P L +G D + Sbjct: 448 CIRF--DNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQI 505 Query: 367 AAGTHDGSVYFWATPRQVPSLQHLCRMSIR 396 + +HD ++ W PS Q+ R R Sbjct: 506 ISSSHDDTILIWDFLNVPPSAQNETRSPSR 535 Score = 67.8 bits (164), Expect = 2e-11 Identities = 65/243 (26%), Positives = 100/243 (41%), Gaps = 26/243 (10%) Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198 D + +GL + IKIWD + + L L HT V L + ++V+ S D T+RVW Sbjct: 249 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY---DERVIVTGSSDSTVRVW 305 Query: 199 DLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMI---RKLEGH 255 D+ + G ++ L H V FS + CS S AV W+M T I R L GH Sbjct: 306 DV-NTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAV--WDMASATDITLRRVLVGH 362 Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVR 315 V DF D + +AS D + +W + + + R + Sbjct: 363 RAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTL-------------NGHKRGIA 407 Query: 316 SVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSV 375 + + D L V S + D +R W I+ ++V L D + +G +DG + Sbjct: 408 CLQY-RDRL-VVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKI 465 Query: 376 YFW 378 W Sbjct: 466 KVW 468 Score = 41.2 bits (95), Expect = 0.002 Identities = 43/164 (26%), Positives = 64/164 (39%), Gaps = 26/164 (15%) Query: 45 DGSYFAWSQGHRTVKLVPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKPREHII 104 D Y + G RT+K+ S C L+G K R R G N R I Sbjct: 372 DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR-DRLVVSGSSDNTIRLWDI 430 Query: 105 DCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTG---- 160 +CG + L E+ RC+ D + +G +G+IK+WD+ Sbjct: 431 ECGACLRVL----EGHEELVRCIRF---------DNKRIVSGAYDGKIKVWDLQAALDPR 477 Query: 161 -----KLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWD 199 L LV+H+ V L F ++S+S D T+ +WD Sbjct: 478 APASTLCLRTLVEHSGRVFRLQF---DEFQIISSSHDDTILIWD 518 >gi|148536855 coatomer protein complex, subunit alpha isoform 1 [Homo sapiens] Length = 1233 Score = 81.3 bits (199), Expect = 2e-15 Identities = 66/259 (25%), Positives = 111/259 (42%), Gaps = 29/259 (11%) Query: 143 LATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKD 202 + T L+NG I++WD L+ +H VR + F L VS D ++VW+ K Sbjct: 24 ILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLF-VSGGDDYKIKVWNYKL 82 Query: 203 DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVAC 262 + +L GH +++ + F + + S + + +WN T + L GH+H V+ Sbjct: 83 RRCLFTLL-GHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCA 141 Query: 263 DFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPP--------TPIFAGGANDRWV 314 F P L+ +AS D V +WD + +L P T + G D V Sbjct: 142 QFHPTEDLVVSASLDQTVRVWDISG----LRKKNLSPGAVESDVRGITGVDLFGTTDAVV 197 Query: 315 RSVSFSHD-GLH----------VASLADDKMVRFWRIDEDYPVQV----APLSNGLCCAF 359 + V HD G++ + S ADD+ V+ WR++E +V +N C F Sbjct: 198 KHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVF 257 Query: 360 STDGSVLAAGTHDGSVYFW 378 ++ + + D S+ W Sbjct: 258 HPRQELILSNSEDKSIRVW 276 Score = 56.6 bits (135), Expect = 4e-08 Identities = 42/162 (25%), Positives = 65/162 (40%), Gaps = 30/162 (18%) Query: 152 IKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKD--------- 202 I++W+ + + L H V F P L+ VSAS D+T+RVWD+ Sbjct: 117 IRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLV-VSASLDQTVRVWDISGLRKKNLSPG 175 Query: 203 ------------------DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMD 244 D + VL GH V AF P ++ S + V +W M+ Sbjct: 176 AVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235 Query: 245 --KYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 284 K + GH+++V F P L+ + S D + +WD Sbjct: 236 ESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWD 277 Score = 40.0 bits (92), Expect = 0.004 Identities = 35/165 (21%), Positives = 62/165 (37%), Gaps = 17/165 (10%) Query: 217 VYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASY 276 V +F P + + + + LW+ T+I K + H V DF L + Sbjct: 12 VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGD 71 Query: 277 DTRVYIWDPHNGDILME-FGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMV 335 D ++ +W+ L GHL ++R+ F H+ + S +DD+ + Sbjct: 72 DYKIKVWNYKLRRCLFTLLGHL--------------DYIRTTFFHHEYPWILSASDDQTI 117 Query: 336 RFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW 378 R W V V N +C F ++ + + D +V W Sbjct: 118 RVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVW 162 Score = 40.0 bits (92), Expect = 0.004 Identities = 25/92 (27%), Positives = 41/92 (44%), Gaps = 2/92 (2%) Query: 166 LVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNM-MKVLRGHQNWVYSCAFSP 224 L H V F P LI VS + D+ +++W + + + RGH N V F P Sbjct: 201 LEGHDRGVNWAAFHPTMPLI-VSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHP 259 Query: 225 DSSMLCSVGASKAVFLWNMDKYTMIRKLEGHH 256 ++ S K++ +W+M K T ++ H Sbjct: 260 RQELILSNSEDKSIRVWDMSKRTGVQTFRRDH 291 Score = 35.4 bits (80), Expect = 0.098 Identities = 53/198 (26%), Positives = 79/198 (39%), Gaps = 26/198 (13%) Query: 38 WTVAFAPDGSYFAWSQGHRTVKLV-----PWSQCLQNFLLHGTKNVTNSSSL-RLPRQNS 91 W ++ + D + W+ RT V + C Q H T+++ S+SL + R Sbjct: 107 WILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQ---FHPTEDLVVSASLDQTVRVWD 163 Query: 92 DGGQKNK---PREHIIDCGDIVWSLAFGSS------VPEKQSRCVNIEWHRFRFGQDQLL 142 G + K P D I FG++ V E R VN W F L Sbjct: 164 ISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVN--WAAFH--PTMPL 219 Query: 143 LATGLNNGRIKIWDVYTGKL--LLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDL 200 + +G ++ ++KIW + K + H V F P LIL S S DK++RVWD+ Sbjct: 220 IVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELIL-SNSEDKSIRVWDM 278 Query: 201 KDDGNMMKVLRGHQN-WV 217 + R H WV Sbjct: 279 SKRTGVQTFRRDHDRFWV 296 >gi|148536853 coatomer protein complex, subunit alpha isoform 2 [Homo sapiens] Length = 1224 Score = 81.3 bits (199), Expect = 2e-15 Identities = 66/259 (25%), Positives = 111/259 (42%), Gaps = 29/259 (11%) Query: 143 LATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKD 202 + T L+NG I++WD L+ +H VR + F L VS D ++VW+ K Sbjct: 24 ILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLF-VSGGDDYKIKVWNYKL 82 Query: 203 DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVAC 262 + +L GH +++ + F + + S + + +WN T + L GH+H V+ Sbjct: 83 RRCLFTLL-GHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCA 141 Query: 263 DFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPP--------TPIFAGGANDRWV 314 F P L+ +AS D V +WD + +L P T + G D V Sbjct: 142 QFHPTEDLVVSASLDQTVRVWDISG----LRKKNLSPGAVESDVRGITGVDLFGTTDAVV 197 Query: 315 RSVSFSHD-GLH----------VASLADDKMVRFWRIDEDYPVQV----APLSNGLCCAF 359 + V HD G++ + S ADD+ V+ WR++E +V +N C F Sbjct: 198 KHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVF 257 Query: 360 STDGSVLAAGTHDGSVYFW 378 ++ + + D S+ W Sbjct: 258 HPRQELILSNSEDKSIRVW 276 Score = 56.6 bits (135), Expect = 4e-08 Identities = 42/162 (25%), Positives = 65/162 (40%), Gaps = 30/162 (18%) Query: 152 IKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKD--------- 202 I++W+ + + L H V F P L+ VSAS D+T+RVWD+ Sbjct: 117 IRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLV-VSASLDQTVRVWDISGLRKKNLSPG 175 Query: 203 ------------------DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMD 244 D + VL GH V AF P ++ S + V +W M+ Sbjct: 176 AVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235 Query: 245 --KYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 284 K + GH+++V F P L+ + S D + +WD Sbjct: 236 ESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWD 277 Score = 40.0 bits (92), Expect = 0.004 Identities = 35/165 (21%), Positives = 62/165 (37%), Gaps = 17/165 (10%) Query: 217 VYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASY 276 V +F P + + + + LW+ T+I K + H V DF L + Sbjct: 12 VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGD 71 Query: 277 DTRVYIWDPHNGDILME-FGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMV 335 D ++ +W+ L GHL ++R+ F H+ + S +DD+ + Sbjct: 72 DYKIKVWNYKLRRCLFTLLGHL--------------DYIRTTFFHHEYPWILSASDDQTI 117 Query: 336 RFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW 378 R W V V N +C F ++ + + D +V W Sbjct: 118 RVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVW 162 Score = 40.0 bits (92), Expect = 0.004 Identities = 25/92 (27%), Positives = 41/92 (44%), Gaps = 2/92 (2%) Query: 166 LVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNM-MKVLRGHQNWVYSCAFSP 224 L H V F P LI VS + D+ +++W + + + RGH N V F P Sbjct: 201 LEGHDRGVNWAAFHPTMPLI-VSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHP 259 Query: 225 DSSMLCSVGASKAVFLWNMDKYTMIRKLEGHH 256 ++ S K++ +W+M K T ++ H Sbjct: 260 RQELILSNSEDKSIRVWDMSKRTGVQTFRRDH 291 Score = 35.4 bits (80), Expect = 0.098 Identities = 53/198 (26%), Positives = 79/198 (39%), Gaps = 26/198 (13%) Query: 38 WTVAFAPDGSYFAWSQGHRTVKLV-----PWSQCLQNFLLHGTKNVTNSSSL-RLPRQNS 91 W ++ + D + W+ RT V + C Q H T+++ S+SL + R Sbjct: 107 WILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQ---FHPTEDLVVSASLDQTVRVWD 163 Query: 92 DGGQKNK---PREHIIDCGDIVWSLAFGSS------VPEKQSRCVNIEWHRFRFGQDQLL 142 G + K P D I FG++ V E R VN W F L Sbjct: 164 ISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVN--WAAFH--PTMPL 219 Query: 143 LATGLNNGRIKIWDVYTGKL--LLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDL 200 + +G ++ ++KIW + K + H V F P LIL S S DK++RVWD+ Sbjct: 220 IVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELIL-SNSEDKSIRVWDM 278 Query: 201 KDDGNMMKVLRGHQN-WV 217 + R H WV Sbjct: 279 SKRTGVQTFRRDHDRFWV 296 >gi|48928048 F-box and WD repeat domain containing 11 isoform A [Homo sapiens] Length = 508 Score = 81.3 bits (199), Expect = 2e-15 Identities = 65/270 (24%), Positives = 114/270 (42%), Gaps = 35/270 (12%) Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198 D+ ++ TG ++ +++WDV TG++L L+ H E V L F+ + ++V+ S+D+++ VW Sbjct: 255 DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS---NGLMVTCSKDRSIAVW 311 Query: 199 DLKD--DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHH 256 D+ D + +VL GH+ V F D + S + + +W+ +R L GH Sbjct: 312 DMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHK 369 Query: 257 HDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVR 315 + + L+ + S D + +WD G L GH + VR Sbjct: 370 RGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGH--------------EELVR 413 Query: 316 SVSFSHDGLHVASLADDKMVRFW----RIDEDYPVQVAPL-----SNGLCCAFSTDGSVL 366 + F D + S A D ++ W +D P L +G D + Sbjct: 414 CIRF--DNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQI 471 Query: 367 AAGTHDGSVYFWATPRQVPSLQHLCRMSIR 396 + +HD ++ W PS Q+ R R Sbjct: 472 ISSSHDDTILIWDFLNVPPSAQNETRSPSR 501 Score = 67.8 bits (164), Expect = 2e-11 Identities = 65/243 (26%), Positives = 100/243 (41%), Gaps = 26/243 (10%) Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198 D + +GL + IKIWD + + L L HT V L + ++V+ S D T+RVW Sbjct: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY---DERVIVTGSSDSTVRVW 271 Query: 199 DLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMI---RKLEGH 255 D+ + G ++ L H V FS + CS S AV W+M T I R L GH Sbjct: 272 DV-NTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAV--WDMASATDITLRRVLVGH 328 Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVR 315 V DF D + +AS D + +W + + + R + Sbjct: 329 RAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTL-------------NGHKRGIA 373 Query: 316 SVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSV 375 + + D L V S + D +R W I+ ++V L D + +G +DG + Sbjct: 374 CLQY-RDRL-VVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKI 431 Query: 376 YFW 378 W Sbjct: 432 KVW 434 Score = 41.2 bits (95), Expect = 0.002 Identities = 43/164 (26%), Positives = 64/164 (39%), Gaps = 26/164 (15%) Query: 45 DGSYFAWSQGHRTVKLVPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKPREHII 104 D Y + G RT+K+ S C L+G K R R G N R I Sbjct: 338 DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR-DRLVVSGSSDNTIRLWDI 396 Query: 105 DCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTG---- 160 +CG + L E+ RC+ D + +G +G+IK+WD+ Sbjct: 397 ECGACLRVL----EGHEELVRCIRF---------DNKRIVSGAYDGKIKVWDLQAALDPR 443 Query: 161 -----KLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWD 199 L LV+H+ V L F ++S+S D T+ +WD Sbjct: 444 APASTLCLRTLVEHSGRVFRLQF---DEFQIISSSHDDTILIWD 484 >gi|102470001 PQQ repeat and WD repeat domain containing [Homo sapiens] Length = 472 Score = 81.3 bits (199), Expect = 2e-15 Identities = 45/180 (25%), Positives = 81/180 (45%), Gaps = 20/180 (11%) Query: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 228 HT + F PD + S S D+ +++WD+ ++ + + H N + +C F+ Sbjct: 229 HTRSITSCCFDPDSQRV-ASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHF 287 Query: 229 LCSVGASKAVFLWNM------DKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYI 282 LC+ K + +WN+ + + ++GH V +C F+ D + L + +D V I Sbjct: 288 LCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAI 347 Query: 283 WDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDE 342 WD G + G ND WV V+ S++ + S + D+ +R W I+E Sbjct: 348 WDVAEG------------YRKLSLKGHND-WVMDVAISNNKKWILSASKDRTMRLWNIEE 394 Score = 65.9 bits (159), Expect = 7e-11 Identities = 41/139 (29%), Positives = 73/139 (52%), Gaps = 7/139 (5%) Query: 152 IKIWDVYTGKLLLNLVD-HTEVVRDLTFAPDGSLILVSASRDKTLRVWDL-----KDDGN 205 IKIWDV + LL + H+ + + F G + S S DK L++W++ ++ G Sbjct: 254 IKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTS-SWDKNLKIWNVHTGEFRNCGA 312 Query: 206 MMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFS 265 + +++GH+ V SC F+ DSS L S G + V +W++ + L+GH+ V+ S Sbjct: 313 CVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAIS 372 Query: 266 PDGALLATASYDTRVYIWD 284 + + +AS D + +W+ Sbjct: 373 NNKKWILSASKDRTMRLWN 391 Score = 55.8 bits (133), Expect = 7e-08 Identities = 36/119 (30%), Positives = 54/119 (45%), Gaps = 13/119 (10%) Query: 252 LEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGAND 311 L GH H V C F D L + SYD V +WDP +G ++ +F H P P+ Sbjct: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEH--RPKAPVV------ 149 Query: 312 RWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPV-QVAPLSNGLCCAFSTDGSVLAAG 369 S + D V + + DK VR W ++ + +V + + C FS DG + +G Sbjct: 150 ----ECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSG 204 Score = 54.3 bits (129), Expect = 2e-07 Identities = 49/205 (23%), Positives = 78/205 (38%), Gaps = 34/205 (16%) Query: 208 KVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH-HHDVVACDFSP 266 K+L GH++ V +C F D + L S V LW+ +++R E VV C + Sbjct: 96 KILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITG 155 Query: 267 DGALLATASYDTRVYIWDPHNGDILMEFGH-------LFPPPTPIFAGG----------- 308 D + + ASYD V WD G +L + + F P G Sbjct: 156 DSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMD 215 Query: 309 ---------ANDRWVRSVS---FSHDGLHVASLADDKMVRFWRIDEDYPVQVAPL--SNG 354 D RS++ F D VAS++ D+ ++ W + + SN Sbjct: 216 AENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNA 275 Query: 355 LC-CAFSTDGSVLAAGTHDGSVYFW 378 + C F+ G L + D ++ W Sbjct: 276 ISNCCFTFSGHFLCTSSWDKNLKIW 300 Score = 44.7 bits (104), Expect = 2e-04 Identities = 24/76 (31%), Positives = 44/76 (57%), Gaps = 1/76 (1%) Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195 F +D L +G + + IWDV G L+L H + V D+ + + IL SAS+D+T+ Sbjct: 329 FARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWIL-SASKDRTM 387 Query: 196 RVWDLKDDGNMMKVLR 211 R+W++++ + V++ Sbjct: 388 RLWNIEEIDEIPLVIK 403 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.322 0.137 0.444 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 17,993,736 Number of Sequences: 37866 Number of extensions: 810764 Number of successful extensions: 4499 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 240 Number of HSP's successfully gapped in prelim test: 111 Number of HSP's that attempted gapping in prelim test: 1616 Number of HSP's gapped (non-prelim): 1540 length of query: 421 length of database: 18,247,518 effective HSP length: 105 effective length of query: 316 effective length of database: 14,271,588 effective search space: 4509821808 effective search space used: 4509821808 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.