Guide to the Human Genome
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Search of human proteins with 18677720

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
sapiens]
         (421 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ...   880   0.0  
gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo ...   547   e-156
gi|8923881 WD SOCS-box protein 2 [Homo sapiens]                       394   e-110
gi|113865883 WD repeat domain 38 [Homo sapiens]                       132   6e-31
gi|16554629 WD repeat domain 5 [Homo sapiens]                         117   3e-26
gi|16554627 WD repeat domain 5 [Homo sapiens]                         117   3e-26
gi|23199987 WD repeat domain 5B [Homo sapiens]                        110   2e-24
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     96   5e-20
gi|26665869 WD repeat domain 51B [Homo sapiens]                        96   5e-20
gi|32189425 WD repeat domain 69 [Homo sapiens]                         93   4e-19
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]            92   9e-19
gi|13376840 WD repeat domain 61 [Homo sapiens]                         91   2e-18
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H...    90   4e-18
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H...    90   4e-18
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho...    90   4e-18
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho...    90   4e-18
gi|21071067 TBP-associated factor 5 [Homo sapiens]                     89   7e-18
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...    89   1e-17
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     88   2e-17
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             86   5e-17
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             86   5e-17
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             86   5e-17
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]    84   3e-16
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [...    83   4e-16
gi|5803221 WD repeat-containing protein 3 [Homo sapiens]               82   1e-15
gi|48928050 F-box and WD repeat domain containing 11 isoform C [...    81   2e-15
gi|148536855 coatomer protein complex, subunit alpha isoform 1 [...    81   2e-15
gi|148536853 coatomer protein complex, subunit alpha isoform 2 [...    81   2e-15
gi|48928048 F-box and WD repeat domain containing 11 isoform A [...    81   2e-15
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa...    81   2e-15

>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
           sapiens]
          Length = 421

 Score =  880 bits (2275), Expect = 0.0
 Identities = 421/421 (100%), Positives = 421/421 (100%)

Query: 1   MASFPPRVNEKEIVRLRTIGELLAPAAPFDKKCGRENWTVAFAPDGSYFAWSQGHRTVKL 60
           MASFPPRVNEKEIVRLRTIGELLAPAAPFDKKCGRENWTVAFAPDGSYFAWSQGHRTVKL
Sbjct: 1   MASFPPRVNEKEIVRLRTIGELLAPAAPFDKKCGRENWTVAFAPDGSYFAWSQGHRTVKL 60

Query: 61  VPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVP 120
           VPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVP
Sbjct: 61  VPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVP 120

Query: 121 EKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAP 180
           EKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAP
Sbjct: 121 EKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAP 180

Query: 181 DGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFL 240
           DGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFL
Sbjct: 181 DGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFL 240

Query: 241 WNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPP 300
           WNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPP
Sbjct: 241 WNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPP 300

Query: 301 PTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFS 360
           PTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFS
Sbjct: 301 PTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFS 360

Query: 361 TDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR 420
           TDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR
Sbjct: 361 TDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR 420

Query: 421 I 421
           I
Sbjct: 421 I 421


>gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo
           sapiens]
          Length = 275

 Score =  547 bits (1410), Expect = e-156
 Identities = 262/262 (100%), Positives = 262/262 (100%)

Query: 160 GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYS 219
           GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYS
Sbjct: 14  GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYS 73

Query: 220 CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTR 279
           CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTR
Sbjct: 74  CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTR 133

Query: 280 VYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR 339
           VYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR
Sbjct: 134 VYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR 193

Query: 340 IDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVM 399
           IDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVM
Sbjct: 194 IDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVM 253

Query: 400 PTQEVQELPIPSKLLEFLSYRI 421
           PTQEVQELPIPSKLLEFLSYRI
Sbjct: 254 PTQEVQELPIPSKLLEFLSYRI 275



 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 75/295 (25%), Positives = 114/295 (38%), Gaps = 75/295 (25%)

Query: 1   MASFPPRVNEKEIVRLRTIGELLAPAAPFDKKCGRENWTVAFAPDGSYFAWSQGHRTVKL 60
           MASFPPRVNEKEI      G+LL       +        + FAPDGS    S        
Sbjct: 1   MASFPPRVNEKEI------GKLLLNLVDHTEVVR----DLTFAPDGSLILVS-------- 42

Query: 61  VPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVP 120
                             +   +LR+     DG      R H     + V+S AF     
Sbjct: 43  -----------------ASRDKTLRVWDLKDDGNMMKVLRGH----QNWVYSCAFSPD-- 79

Query: 121 EKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAP 180
                               +L + G +   + +W++    ++  L  H   V    F+P
Sbjct: 80  ------------------SSMLCSVGASKA-VFLWNMDKYTMIRKLEGHHHDVVACDFSP 120

Query: 181 DGSLILVSASRDKTLRVWDLKDDGNMMK----------VLRGHQN--WVYSCAFSPDSSM 228
           DG+L L +AS D  + +WD  +   +M+          +  G  N  WV S +FS D   
Sbjct: 121 DGAL-LATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLH 179

Query: 229 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIW 283
           + S+   K V  W +D+   ++       + + C FS DG++LA  ++D  VY W
Sbjct: 180 VASLADDKMVRFWRIDEDYPVQ--VAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 232


>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
          Length = 404

 Score =  394 bits (1013), Expect = e-110
 Identities = 205/400 (51%), Positives = 260/400 (65%), Gaps = 12/400 (3%)

Query: 23  LAPAAP--FDKKCGRENWTVAFAPDGSYFAWSQGHRTVKLVPWSQCLQNFLLHGTKNVTN 80
           L P  P  FD K   E W+VAF+PDGS+FAWSQGH  VKL+PW    + F+  G +  + 
Sbjct: 13  LKPGRPHQFDWKSSCETWSVAFSPDGSWFAWSQGHCIVKLIPWP-LEEQFIPKGFEAKSR 71

Query: 81  SSSLRLPRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQ 140
           SS      +N   G +  P+E  +DCG IVW LAF S  P   SR +    H        
Sbjct: 72  SS------KNETKG-RGSPKEKTLDCGQIVWGLAF-SPWPSPPSRKLWARHHPQVPDVSC 123

Query: 141 LLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDL 200
           L+LATGLN+G+IKIW+V TG LLLNL  H +VVRDL+F P GSLILVSASRDKTLR+WDL
Sbjct: 124 LVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDL 183

Query: 201 KDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVV 260
              G  ++VL GH  WVY C+ SPD SMLCS    K+VFLW+M  YT+IRKLEGH   VV
Sbjct: 184 NKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVV 243

Query: 261 ACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFS 320
           +CDFSPD ALL TASYDT V +WDP+ G+ L    H    P  +     +   +RSV FS
Sbjct: 244 SCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPA-MDDSDVHISSLRSVCFS 302

Query: 321 HDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWAT 380
            +GL++A++ADD+++R W ++   P+  AP++NGLCC F   G V+A GT DG V FW  
Sbjct: 303 PEGLYLATVADDRLLRIWALELKTPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFWTA 362

Query: 381 PRQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR 420
           PR + SL+HLCR ++R  + T +V  LPIP K+ EFL+YR
Sbjct: 363 PRVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 402


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score =  132 bits (332), Expect = 6e-31
 Identities = 91/270 (33%), Positives = 134/270 (49%), Gaps = 35/270 (12%)

Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
           F  D  +L TG  +G +  W+  +G+LL  L  HT  V+   F+PDG L   SAS D T+
Sbjct: 29  FSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF-ASASCDCTV 87

Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
           R+WD+      ++VL+GHQ  V + +FSPDS  L S G  K V LW++    M+R L GH
Sbjct: 88  RLWDVAR-AKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGH 146

Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWD--------------PHNGDI---------LM 292
              + + DFSP    LAT S+D+ V+IWD               H+ +I         L+
Sbjct: 147 RDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLL 206

Query: 293 EFG------HLFPPPTP--IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDY 344
             G      H++ P T   +     +  WV+S++FS D L +AS    +MV+ W  +   
Sbjct: 207 ASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGK 266

Query: 345 PVQV--APLSNGLCCAFSTDGSVLAAGTHD 372
            ++     L     CAF+ DG +L +G  D
Sbjct: 267 CLETLKGVLDVAHTCAFTPDGKILVSGAAD 296



 Score = 86.3 bits (212), Expect = 5e-17
 Identities = 64/224 (28%), Positives = 104/224 (46%), Gaps = 14/224 (6%)

Query: 105 DCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLL 164
           DC   +W +A    +   +    ++E     F  D   LA+G  + R+ +WDV +G++L 
Sbjct: 84  DCTVRLWDVARAKCLRVLKGHQRSVE--TVSFSPDSRQLASGGWDKRVMLWDVQSGQMLR 141

Query: 165 NLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLK--DDGNMMKVLRGHQNWVYSCAF 222
            LV H + ++   F+P  +  L + S D T+ +WDL+        + L GH   + SC  
Sbjct: 142 LLVGHRDSIQSSDFSPTVNC-LATGSWDSTVHIWDLRMVTPAVSHQALEGHSANI-SCLC 199

Query: 223 SPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYI 282
              S +L S    K + +W     +++ +L+GH   V +  FSPD   LA+A Y   V +
Sbjct: 200 YSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKV 259

Query: 283 WDPHNGDIL------MEFGH--LFPPPTPIFAGGANDRWVRSVS 318
           WD + G  L      ++  H   F P   I   GA D+  R +S
Sbjct: 260 WDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQIS 303



 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 58/186 (31%), Positives = 78/186 (41%), Gaps = 17/186 (9%)

Query: 207 MKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSP 266
           +K    H   V S AFSPD  ML +      V+ W      ++ +L GH   V  C FSP
Sbjct: 14  VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73

Query: 267 DGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLH 325
           DG L A+AS D  V +WD      L    GH               R V +VSFS D   
Sbjct: 74  DGHLFASASCDCTVRLWDVARAKCLRVLKGH--------------QRSVETVSFSPDSRQ 119

Query: 326 VASLADDKMVRFWRIDEDYPVQ--VAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQ 383
           +AS   DK V  W +     ++  V    +     FS   + LA G+ D +V+ W     
Sbjct: 120 LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV 179

Query: 384 VPSLQH 389
            P++ H
Sbjct: 180 TPAVSH 185



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 67/241 (27%), Positives = 109/241 (45%), Gaps = 20/241 (8%)

Query: 42  FAPDGSYFAWSQGHRTVKL--VPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKP 99
           F+PDG  FA +    TV+L  V  ++CL+    H  ++V   S     RQ + GG   + 
Sbjct: 71  FSPDGHLFASASCDCTVRLWDVARAKCLRVLKGH-QRSVETVSFSPDSRQLASGGWDKRV 129

Query: 100 REHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYT 159
                    ++W +  G  +        +I+     F      LATG  +  + IWD+  
Sbjct: 130 ---------MLWDVQSGQMLRLLVGHRDSIQ--SSDFSPTVNCLATGSWDSTVHIWDLRM 178

Query: 160 GKLLLN---LVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNW 216
               ++   L  H+  +  L ++  G  +L S S DKT+ +W      +++  L+GH  W
Sbjct: 179 VTPAVSHQALEGHSANISCLCYSASG--LLASGSWDKTIHIWK-PTTSSLLIQLKGHVTW 235

Query: 217 VYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASY 276
           V S AFSPD   L S G S+ V +W+ +    +  L+G       C F+PDG +L + + 
Sbjct: 236 VKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAA 295

Query: 277 D 277
           D
Sbjct: 296 D 296


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  117 bits (292), Expect = 3e-26
 Identities = 74/249 (29%), Positives = 121/249 (48%), Gaps = 19/249 (7%)

Query: 135 RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKT 194
           +F  +   LA+   +  IKIW  Y GK    +  H   + D+ ++ D +L LVSAS DKT
Sbjct: 52  KFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL-LVSASDDKT 110

Query: 195 LRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEG 254
           L++WD+   G  +K L+GH N+V+ C F+P S+++ S    ++V +W++     ++ L  
Sbjct: 111 LKIWDVSS-GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPA 169

Query: 255 HHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWV 314
           H   V A  F+ DG+L+ ++SYD    IWD  +G  L        PP            V
Sbjct: 170 HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP------------V 217

Query: 315 RSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQV-APLSNGLCCAFS----TDGSVLAAG 369
             V FS +G ++ +   D  ++ W   +   ++      N   C F+    T G  + +G
Sbjct: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSG 277

Query: 370 THDGSVYFW 378
           + D  VY W
Sbjct: 278 SEDNLVYIW 286



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 66/227 (29%), Positives = 105/227 (46%), Gaps = 32/227 (14%)

Query: 162 LLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCA 221
           L   L  HT+ V  + F+P+G   L S+S DK +++W    DG   K + GH+  +   A
Sbjct: 37  LKFTLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAY-DGKFEKTISGHKLGISDVA 94

Query: 222 FSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVY 281
           +S DS++L S    K + +W++     ++ L+GH + V  C+F+P   L+ + S+D  V 
Sbjct: 95  WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154

Query: 282 IWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW--- 338
           IWD   G  L                 A+   V +V F+ DG  + S + D + R W   
Sbjct: 155 IWDVKTGKCLKTL-------------PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201

Query: 339 -------RIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378
                   ID+D P    P+S      FS +G  + A T D ++  W
Sbjct: 202 SGQCLKTLIDDDNP----PVS---FVKFSPNGKYILAATLDNTLKLW 241



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 46/155 (29%), Positives = 80/155 (51%), Gaps = 10/155 (6%)

Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEV-VRDLTFAPDGSLILVSASRDKT 194
           F +D  L+ +   +G  +IWD  +G+ L  L+D     V  + F+P+G  IL +A+ D T
Sbjct: 179 FNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYIL-AATLDNT 237

Query: 195 LRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDS----SMLCSVGASKAVFLWNMDKYTMIR 250
           L++WD    G  +K   GH+N  Y C F+  S      + S      V++WN+    +++
Sbjct: 238 LKLWDYSK-GKCLKTYTGHKNEKY-CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ 295

Query: 251 KLEGHHHDVVACDFSPDGALLATASY--DTRVYIW 283
           KL+GH   V++    P   ++A+A+   D  + +W
Sbjct: 296 KLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 46/174 (26%), Positives = 72/174 (41%), Gaps = 17/174 (9%)

Query: 210 LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGA 269
           L GH   V S  FSP+   L S  A K + +W        + + GH   +    +S D  
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100

Query: 270 LLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVAS 328
           LL +AS D  + IWD  +G  L    GH                +V   +F+     + S
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGH--------------SNYVFCCNFNPQSNLIVS 146

Query: 329 LADDKMVRFWRIDEDYPVQVAPLSNGLCCA--FSTDGSVLAAGTHDGSVYFWAT 380
            + D+ VR W +     ++  P  +    A  F+ DGS++ + ++DG    W T
Sbjct: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 36/136 (26%), Positives = 61/136 (44%), Gaps = 17/136 (12%)

Query: 246 YTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPI 304
           Y +   L GH   V +  FSP+G  LA++S D  + IW  ++G       GH        
Sbjct: 35  YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKL------ 88

Query: 305 FAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTD 362
              G +D     V++S D   + S +DDK ++ W +     ++     +    CC F+  
Sbjct: 89  ---GISD-----VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ 140

Query: 363 GSVLAAGTHDGSVYFW 378
            +++ +G+ D SV  W
Sbjct: 141 SNLIVSGSFDESVRIW 156


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  117 bits (292), Expect = 3e-26
 Identities = 74/249 (29%), Positives = 121/249 (48%), Gaps = 19/249 (7%)

Query: 135 RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKT 194
           +F  +   LA+   +  IKIW  Y GK    +  H   + D+ ++ D +L LVSAS DKT
Sbjct: 52  KFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL-LVSASDDKT 110

Query: 195 LRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEG 254
           L++WD+   G  +K L+GH N+V+ C F+P S+++ S    ++V +W++     ++ L  
Sbjct: 111 LKIWDVSS-GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPA 169

Query: 255 HHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWV 314
           H   V A  F+ DG+L+ ++SYD    IWD  +G  L        PP            V
Sbjct: 170 HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP------------V 217

Query: 315 RSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQV-APLSNGLCCAFS----TDGSVLAAG 369
             V FS +G ++ +   D  ++ W   +   ++      N   C F+    T G  + +G
Sbjct: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSG 277

Query: 370 THDGSVYFW 378
           + D  VY W
Sbjct: 278 SEDNLVYIW 286



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 66/227 (29%), Positives = 105/227 (46%), Gaps = 32/227 (14%)

Query: 162 LLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCA 221
           L   L  HT+ V  + F+P+G   L S+S DK +++W    DG   K + GH+  +   A
Sbjct: 37  LKFTLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAY-DGKFEKTISGHKLGISDVA 94

Query: 222 FSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVY 281
           +S DS++L S    K + +W++     ++ L+GH + V  C+F+P   L+ + S+D  V 
Sbjct: 95  WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154

Query: 282 IWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW--- 338
           IWD   G  L                 A+   V +V F+ DG  + S + D + R W   
Sbjct: 155 IWDVKTGKCLKTL-------------PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201

Query: 339 -------RIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378
                   ID+D P    P+S      FS +G  + A T D ++  W
Sbjct: 202 SGQCLKTLIDDDNP----PVS---FVKFSPNGKYILAATLDNTLKLW 241



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 46/155 (29%), Positives = 80/155 (51%), Gaps = 10/155 (6%)

Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEV-VRDLTFAPDGSLILVSASRDKT 194
           F +D  L+ +   +G  +IWD  +G+ L  L+D     V  + F+P+G  IL +A+ D T
Sbjct: 179 FNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYIL-AATLDNT 237

Query: 195 LRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDS----SMLCSVGASKAVFLWNMDKYTMIR 250
           L++WD    G  +K   GH+N  Y C F+  S      + S      V++WN+    +++
Sbjct: 238 LKLWDYSK-GKCLKTYTGHKNEKY-CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ 295

Query: 251 KLEGHHHDVVACDFSPDGALLATASY--DTRVYIW 283
           KL+GH   V++    P   ++A+A+   D  + +W
Sbjct: 296 KLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 46/174 (26%), Positives = 72/174 (41%), Gaps = 17/174 (9%)

Query: 210 LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGA 269
           L GH   V S  FSP+   L S  A K + +W        + + GH   +    +S D  
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100

Query: 270 LLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVAS 328
           LL +AS D  + IWD  +G  L    GH                +V   +F+     + S
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGH--------------SNYVFCCNFNPQSNLIVS 146

Query: 329 LADDKMVRFWRIDEDYPVQVAPLSNGLCCA--FSTDGSVLAAGTHDGSVYFWAT 380
            + D+ VR W +     ++  P  +    A  F+ DGS++ + ++DG    W T
Sbjct: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 36/136 (26%), Positives = 61/136 (44%), Gaps = 17/136 (12%)

Query: 246 YTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPI 304
           Y +   L GH   V +  FSP+G  LA++S D  + IW  ++G       GH        
Sbjct: 35  YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKL------ 88

Query: 305 FAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTD 362
              G +D     V++S D   + S +DDK ++ W +     ++     +    CC F+  
Sbjct: 89  ---GISD-----VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ 140

Query: 363 GSVLAAGTHDGSVYFW 378
            +++ +G+ D SV  W
Sbjct: 141 SNLIVSGSFDESVRIW 156


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score =  110 bits (275), Expect = 2e-24
 Identities = 73/249 (29%), Positives = 115/249 (46%), Gaps = 19/249 (7%)

Query: 135 RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKT 194
           +F  +   LA+   +  I IW  Y GK    L  H   + D+ ++ D S  LVSAS DKT
Sbjct: 48  KFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSR-LVSASDDKT 106

Query: 195 LRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEG 254
           L++WD++  G  +K L+GH N+V+ C F+P S+++ S    + V +W +     ++ L  
Sbjct: 107 LKLWDVRS-GKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSA 165

Query: 255 HHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWV 314
           H   V A  F+  G+L+ + SYD    IWD  +G  L        PP            V
Sbjct: 166 HSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPP------------V 213

Query: 315 RSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQV-APLSNGLCCAFS----TDGSVLAAG 369
             V FS +G ++ +   D  ++ W       ++      N   C F+    T G  + +G
Sbjct: 214 SFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSG 273

Query: 370 THDGSVYFW 378
           + D  VY W
Sbjct: 274 SEDNLVYIW 282



 Score = 79.0 bits (193), Expect = 8e-15
 Identities = 62/241 (25%), Positives = 107/241 (44%), Gaps = 17/241 (7%)

Query: 109 IVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVD 168
           I+W    G    EK     N+E     +  D   L +  ++  +K+WDV +GK L  L  
Sbjct: 66  IIWGAYDGKY--EKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKG 123

Query: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 228
           H+  V    F P  +LI +S S D+T+++W++K  G  +K L  H + V +  F+   S+
Sbjct: 124 HSNYVFCCNFNPPSNLI-ISGSFDETVKIWEVK-TGKCLKTLSAHSDPVSAVHFNCSGSL 181

Query: 229 LCSVGASKAVFLWNMDKYTMIRKL-EGHHHDVVACDFSPDGALLATASYDTRVYIWDPHN 287
           + S        +W+      ++ L +  +  V    FSP+G  + TA+ D  + +WD   
Sbjct: 182 IVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSR 241

Query: 288 GDILMEFGHLFPPPTPIFAGGANDRWVRSVSFS-HDGLHVASLADDKMVRFWRIDEDYPV 346
           G  L             + G  N+++    +FS   G  + S ++D +V  W +     V
Sbjct: 242 GRCL-----------KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 290

Query: 347 Q 347
           Q
Sbjct: 291 Q 291



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 47/149 (31%), Positives = 78/149 (52%), Gaps = 10/149 (6%)

Query: 142 LLATGLNNGRIKIWDVYTGKLLLNLVDHTEV-VRDLTFAPDGSLILVSASRDKTLRVWDL 200
           L+ +G  +G  +IWD  +G+ L  LVD     V  + F+P+G  IL +A+ D TL++WD 
Sbjct: 181 LIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYIL-TATLDNTLKLWDY 239

Query: 201 KDDGNMMKVLRGHQNWVYSCAFSPDS----SMLCSVGASKAVFLWNMDKYTMIRKLEGHH 256
              G  +K   GH+N  Y C F+  S      + S      V++WN+    +++KL+GH 
Sbjct: 240 SR-GRCLKTYTGHKNEKY-CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT 297

Query: 257 HDVVACDFSPDGALLATASY--DTRVYIW 283
             V++    P   L+A+A+   D  + +W
Sbjct: 298 DVVISAACHPTENLIASAALENDKTIKLW 326



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 41/172 (23%), Positives = 72/172 (41%), Gaps = 17/172 (9%)

Query: 210 LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGA 269
           L GH   V S  FSP+   L S  A + + +W        + L GH+ ++    +S D +
Sbjct: 37  LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSS 96

Query: 270 LLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVAS 328
            L +AS D  + +WD  +G  L    GH                +V   +F+     + S
Sbjct: 97  RLVSASDDKTLKLWDVRSGKCLKTLKGH--------------SNYVFCCNFNPPSNLIIS 142

Query: 329 LADDKMVRFWRIDEDYPVQVAPLSNGLCCA--FSTDGSVLAAGTHDGSVYFW 378
            + D+ V+ W +     ++     +    A  F+  GS++ +G++DG    W
Sbjct: 143 GSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 33/136 (24%), Positives = 61/136 (44%), Gaps = 17/136 (12%)

Query: 246 YTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILME-FGHLFPPPTPI 304
           Y +   L GH   V +  FSP+G  LA++S D  + IW  ++G      +GH        
Sbjct: 31  YALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGH-------- 82

Query: 305 FAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTD 362
                 +  +  V++S D   + S +DDK ++ W +     ++     +    CC F+  
Sbjct: 83  ------NLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPP 136

Query: 363 GSVLAAGTHDGSVYFW 378
            +++ +G+ D +V  W
Sbjct: 137 SNLIISGSFDETVKIW 152


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 96.3 bits (238), Expect = 5e-20
 Identities = 71/245 (28%), Positives = 112/245 (45%), Gaps = 20/245 (8%)

Query: 142 LLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLK 201
           LLATG ++ R+ +W +     +++L  HT  V  +       LI V+ S+  ++RVWDL 
Sbjct: 35  LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI-VAGSQSGSIRVWDL- 92

Query: 202 DDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVA 261
           +   +++ L GH+  + S  F P    + S      + LW++ +   + +  GH   V  
Sbjct: 93  EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRC 152

Query: 262 CDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFS 320
             FSPDG  LA+A+ D  V +WD   G ++ EF GH  P              V  V F 
Sbjct: 153 LRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGP--------------VNVVEFH 198

Query: 321 HDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDG-SVYF 377
            +   +AS + D+ +RFW +++   V       G      F+ DG  L +G  D   VY 
Sbjct: 199 PNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYG 258

Query: 378 WATPR 382
           W   R
Sbjct: 259 WEPER 263



 Score = 89.7 bits (221), Expect = 4e-18
 Identities = 63/230 (27%), Positives = 100/230 (43%), Gaps = 17/230 (7%)

Query: 105 DCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLL 164
           DC   +WS+   + +         +E    R    + L+  G  +G I++WD+   K+L 
Sbjct: 42  DCRVNLWSINKPNCIMSLTGHTSPVE--SVRLNTPEELIVAGSQSGSIRVWDLEAAKILR 99

Query: 165 NLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSP 224
            L+ H   +  L F P G  +  S S+D  +++WD++  G + +  RGH   V    FSP
Sbjct: 100 TLMGHKANICSLDFHPYGEFV-ASGSQDTNIKLWDIRRKGCVFR-YRGHSQAVRCLRFSP 157

Query: 225 DSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 284
           D   L S      V LW++    M+ +  GH   V   +F P+  LLA+ S D  +  WD
Sbjct: 158 DGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217

Query: 285 PHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKM 334
                ++     +   P P          VRSV F+ DG  + S   D +
Sbjct: 218 LEKFQVV---SCIEGEPGP----------VRSVLFNPDGCCLYSGCQDSL 254



 Score = 34.3 bits (77), Expect = 0.22
 Identities = 37/142 (26%), Positives = 52/142 (36%), Gaps = 31/142 (21%)

Query: 268 GALLATASYDTRVYIWDPHNGDILMEF-GHLFP-------PPTPIFAGGANDRWVR---- 315
           G LLAT   D RV +W  +  + +M   GH  P        P  +   G+    +R    
Sbjct: 33  GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDL 92

Query: 316 -----------------SVSFSHDGLHVASLADDKMVRFWRIDEDYPV-QVAPLSNGL-C 356
                            S+ F   G  VAS + D  ++ W I     V +    S  + C
Sbjct: 93  EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRC 152

Query: 357 CAFSTDGSVLAAGTHDGSVYFW 378
             FS DG  LA+   D +V  W
Sbjct: 153 LRFSPDGKWLASAADDHTVKLW 174



 Score = 31.2 bits (69), Expect = 1.8
 Identities = 26/91 (28%), Positives = 44/91 (48%), Gaps = 8/91 (8%)

Query: 110 VWSLAFGSSVPEKQSRC--VNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLV 167
           +W L  G  + E       VN+      F  ++ LLA+G ++  I+ WD+   +++  + 
Sbjct: 173 LWDLTAGKMMSEFPGHTGPVNV----VEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIE 228

Query: 168 DHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198
                VR + F PDG   L S  +D +LRV+
Sbjct: 229 GEPGPVRSVLFNPDG-CCLYSGCQD-SLRVY 257


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score = 96.3 bits (238), Expect = 5e-20
 Identities = 68/235 (28%), Positives = 106/235 (45%), Gaps = 17/235 (7%)

Query: 143 LATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKD 202
           LAT   +  + +W+          V H +VV  + F+P G+L L SASRD+T+R+W + D
Sbjct: 33  LATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNL-LASASRDRTVRLW-IPD 90

Query: 203 DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVAC 262
                   + H   V S  FS D   L +    K++ +W+M +   +  L  H H V   
Sbjct: 91  KRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCA 150

Query: 263 DFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHD 322
            FSPDG L+ + S D  + IWD  N   +  F            G AN      V F+  
Sbjct: 151 KFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSD--------SVGFAN-----FVDFNPS 197

Query: 323 GLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSV 375
           G  +AS   D+ V+ W +  +  +Q   + +G   C +F   G+ L   + DG++
Sbjct: 198 GTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTL 252



 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 72/233 (30%), Positives = 104/233 (44%), Gaps = 26/233 (11%)

Query: 119 VPEKQSRCVNIEWHR-----FRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVV 173
           +P+K+ +    + H        F  D   LAT   +  IK+W +Y  + L +L  HT  V
Sbjct: 88  IPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWV 147

Query: 174 RDLTFAPDGSLILVSASRDKTLRVWDL--KDDGNMMKVLRGHQNWVYSCAFSPDSSMLCS 231
           R   F+PDG LI VS S DKT+++WD   K   N      G  N+V    F+P  + + S
Sbjct: 148 RCAKFSPDGRLI-VSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFV---DFNPSGTCIAS 203

Query: 232 VGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDIL 291
            G+ + V +W++    +++  + H   V    F P G  L TAS D  + I D   G ++
Sbjct: 204 AGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLI 263

Query: 292 MEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDED 343
               GH  P              V +VSFS  G   AS   D  V  WR + D
Sbjct: 264 YTLQGHTGP--------------VFTVSFSKGGELFASGGADTQVLLWRTNFD 302



 Score = 86.7 bits (213), Expect = 4e-17
 Identities = 60/212 (28%), Positives = 92/212 (43%), Gaps = 17/212 (8%)

Query: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 228
           H   +  L  +P+G   L +AS D  L +W+ K      + + GH++ V S  FSP  ++
Sbjct: 17  HKAAITSLDLSPNGKQ-LATASWDTFLMLWNFKPHARAYRYV-GHKDVVTSVQFSPHGNL 74

Query: 229 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNG 288
           L S    + V LW  DK     + + H   V + DFS DG  LATAS D  + +W  +  
Sbjct: 75  LASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQ 134

Query: 289 DILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQV 348
             L             ++   +  WVR   FS DG  + S ++DK ++ W       V  
Sbjct: 135 RFL-------------YSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181

Query: 349 APLSNGLC--CAFSTDGSVLAAGTHDGSVYFW 378
              S G      F+  G+ +A+   D +V  W
Sbjct: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVW 213



 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 51/182 (28%), Positives = 84/182 (46%), Gaps = 17/182 (9%)

Query: 202 DDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVA 261
           +D  + +  +GH+  + S   SP+   L +      + LWN   +    +  GH   V +
Sbjct: 6   EDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTS 65

Query: 262 CDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFS 320
             FSP G LLA+AS D  V +W P       EF  H  P              VRSV FS
Sbjct: 66  VQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAP--------------VRSVDFS 111

Query: 321 HDGLHVASLADDKMVRFWRI-DEDYPVQVAPLSNGLCCA-FSTDGSVLAAGTHDGSVYFW 378
            DG  +A+ ++DK ++ W +  + +   +   ++ + CA FS DG ++ + + D ++  W
Sbjct: 112 ADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW 171

Query: 379 AT 380
            T
Sbjct: 172 DT 173



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 43/139 (30%), Positives = 64/139 (46%), Gaps = 21/139 (15%)

Query: 250 RKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGA 309
           R  +GH   + + D SP+G  LATAS+DT + +W+             F P    +    
Sbjct: 12  RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWN-------------FKPHARAYRYVG 58

Query: 310 NDRWVRSVSFSHDGLHVASLADDKMVRFWRIDE-----DYPVQVAPLSNGLCCAFSTDGS 364
           +   V SV FS  G  +AS + D+ VR W  D+     ++    AP+ +     FS DG 
Sbjct: 59  HKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRS---VDFSADGQ 115

Query: 365 VLAAGTHDGSVYFWATPRQ 383
            LA  + D S+  W+  RQ
Sbjct: 116 FLATASEDKSIKVWSMYRQ 134


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score = 93.2 bits (230), Expect = 4e-19
 Identities = 85/342 (24%), Positives = 137/342 (40%), Gaps = 28/342 (8%)

Query: 40  VAFAPDGSYFAWSQGHRTVKLVPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKP 99
           VA    GS F      RT KL   +   +   L G +NV  + +      N+  G K   
Sbjct: 98  VALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAF-----NNPYGDKIAT 152

Query: 100 REHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYT 159
                 C   +WS+  G      +     I      F     L+ATG  +   K+WD+  
Sbjct: 153 GSFDKTCK--LWSVETGKCYHTFRGHTAEIVC--LSFNPQSTLVATGSMDTTAKLWDIQN 208

Query: 160 GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYS 219
           G+ +  L  H+  +  L+F   G  I ++ S D T+ VWD  D G  + +L GH   + S
Sbjct: 209 GEEVYTLRGHSAEIISLSFNTSGDRI-ITGSFDHTVVVWD-ADTGRKVNILIGHCAEISS 266

Query: 220 CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTR 279
            +F+ D S++ +    K   LW+      +  L GH  +++   F   G L+ATAS D  
Sbjct: 267 ASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGT 326

Query: 280 VYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW 338
             I+       + +  GH              +  +  +SF+  G H+ + + DK  R W
Sbjct: 327 ARIFSAATRKCIAKLEGH--------------EGEISKISFNPQGNHLLTGSSDKTARIW 372

Query: 339 RIDEDYPVQV--APLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378
                  +QV          CAF+  G+++  G+ D +   W
Sbjct: 373 DAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414



 Score = 82.0 bits (201), Expect = 9e-16
 Identities = 59/230 (25%), Positives = 98/230 (42%), Gaps = 17/230 (7%)

Query: 110 VWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDH 169
           +W +  G  V   +     I    F    D+++  TG  +  + +WD  TG+ +  L+ H
Sbjct: 203 LWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII--TGSFDHTVVVWDADTGRKVNILIGH 260

Query: 170 TEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSML 229
              +   +F  D SLIL + S DKT ++WD  + G  +  L GH + +    F     ++
Sbjct: 261 CAEISSASFNWDCSLIL-TGSMDKTCKLWDATN-GKCVATLTGHDDEILDSCFDYTGKLI 318

Query: 230 CSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGD 289
            +  A     +++      I KLEGH  ++    F+P G  L T S D    IWD   G 
Sbjct: 319 ATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQ 378

Query: 290 ILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR 339
            L            +  G  ++  + S +F++ G  V + + D   R WR
Sbjct: 379 CLQ-----------VLEGHTDE--IFSCAFNYKGNIVITGSKDNTCRIWR 415



 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 60/251 (23%), Positives = 107/251 (42%), Gaps = 24/251 (9%)

Query: 145 TGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDG 204
           TG  +   K+WD  +G+ L  L  H  VV  + F       + + S DKT ++W + + G
Sbjct: 109 TGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSV-ETG 167

Query: 205 NMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDF 264
                 RGH   +   +F+P S+++ +        LW++     +  L GH  ++++  F
Sbjct: 168 KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSF 227

Query: 265 SPDGALLATASYDTRVYIWDPHNG-DILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDG 323
           +  G  + T S+D  V +WD   G  + +  GH                 + S SF+ D 
Sbjct: 228 NTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAE--------------ISSASFNWDC 273

Query: 324 LHVASLADDKMVRFWRIDEDYPVQVAPLSNG----LCCAFSTDGSVLAAGTHDGS--VYF 377
             + + + DK  + W  D      VA L+      L   F   G ++A  + DG+  ++ 
Sbjct: 274 SLILTGSMDKTCKLW--DATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFS 331

Query: 378 WATPRQVPSLQ 388
            AT + +  L+
Sbjct: 332 AATRKCIAKLE 342



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 42/178 (23%), Positives = 72/178 (40%), Gaps = 20/178 (11%)

Query: 206 MMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDF- 264
           + KVL+ H   + + A +   S   +    +   LW+      +  LEGH + V A  F 
Sbjct: 84  LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143

Query: 265 SPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDG 323
           +P G  +AT S+D    +W    G     F GH                 +  +SF+   
Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAE--------------IVCLSFNPQS 189

Query: 324 LHVASLADDKMVRFWRI---DEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378
             VA+ + D   + W I   +E Y ++    +  +  +F+T G  +  G+ D +V  W
Sbjct: 190 TLVATGSMDTTAKLWDIQNGEEVYTLR-GHSAEIISLSFNTSGDRIITGSFDHTVVVW 246



 Score = 33.1 bits (74), Expect = 0.49
 Identities = 26/135 (19%), Positives = 56/135 (41%), Gaps = 14/135 (10%)

Query: 246 YTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIF 305
           + + + L+ H   +     +  G+   T SYD    +WD  +G+   E   L      ++
Sbjct: 82  FYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGE---ELNTLEGHRNVVY 138

Query: 306 AGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRID--EDYPVQVAPLSNGLCCAFSTDG 363
           A   N+ +         G  +A+ + DK  + W ++  + Y       +  +C +F+   
Sbjct: 139 AIAFNNPY---------GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQS 189

Query: 364 SVLAAGTHDGSVYFW 378
           +++A G+ D +   W
Sbjct: 190 TLVATGSMDTTAKLW 204


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score = 92.0 bits (227), Expect = 9e-19
 Identities = 95/379 (25%), Positives = 147/379 (38%), Gaps = 91/379 (24%)

Query: 39  TVAFAPDGSYFAWSQGHRTVKLVPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNK 98
           +VAF+P G Y A   G  TV+    S    +F   G ++   S S     +    G KN 
Sbjct: 119 SVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKN- 177

Query: 99  PREHIIDCGDIV-WSLAFGSSVPEKQSR----CVNIEWHRFRFGQDQLLLATGLNNGRIK 153
                   G I+ W  + G  V    +        + W       +   +A+   +G ++
Sbjct: 178 --------GQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVR 229

Query: 154 IWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGH 213
           IWD   G+    L  HT+ V  L +  DG  +L SAS+D+T++VW    DG + + L+GH
Sbjct: 230 IWDTTAGRCERILTGHTQSVTCLRWGGDG--LLYSASQDRTIKVW-RAHDGVLCRTLQGH 286

Query: 214 QNWVYSCAFSPDSSM------------------------------------------LCS 231
            +WV + A S D ++                                          L S
Sbjct: 287 GHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVS 346

Query: 232 VGASKAVFLWN--MDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGD 289
                 +FLW+   DK  + R + GH   +    FSPD  ++A+AS+D  + +WD   G 
Sbjct: 347 GSDDFTLFLWSPAEDKKPLTR-MTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGK 405

Query: 290 ILMEF-GHL-------FPPPTPIFAGGANDR----W-----------------VRSVSFS 320
            L    GH+       +   + +   G++D     W                 V +V +S
Sbjct: 406 YLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWS 465

Query: 321 HDGLHVASLADDKMVRFWR 339
            DG  VAS   DK +R WR
Sbjct: 466 PDGQRVASGGKDKCLRIWR 484



 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 58/230 (25%), Positives = 90/230 (39%), Gaps = 42/230 (18%)

Query: 160 GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYS 219
           GK L +    TE V D+ + P     + + +R                  L GH   V S
Sbjct: 74  GKTLESQAVETEKVLDIIYQPQAIFRVRAVTR--------------CTSSLEGHSEAVIS 119

Query: 220 CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTR 279
            AFSP    L S      V  W++   T     +GH H V++  +SPDG  LA+   + +
Sbjct: 120 VAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQ 179

Query: 280 VYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSF-----SHDGLHVASLADDKM 334
           + +WDP  G    + G              + +W+  +S+     + +  +VAS + D  
Sbjct: 180 ILLWDPSTG---KQVGRTL---------AGHSKWITGLSWEPLHANPECRYVASSSKDGS 227

Query: 335 VRFW--------RIDEDYPVQVAPL---SNGLCCAFSTDGSVLAAGTHDG 373
           VR W        RI   +   V  L    +GL  + S D ++     HDG
Sbjct: 228 VRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDG 277


>gi|13376840 WD repeat domain 61 [Homo sapiens]
          Length = 305

 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 49/149 (32%), Positives = 82/149 (55%), Gaps = 2/149 (1%)

Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
           +  D   LA+G  +G I I+D+ TGKLL  L  H   +R LTF+PD  L LV+AS D  +
Sbjct: 156 YSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQL-LVTASDDGYI 214

Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
           +++D++   N+   L GH +WV + AF PD +   S  + K+V +W++   T +     H
Sbjct: 215 KIYDVQH-ANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDH 273

Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWD 284
              V    ++ +G+ + +   D  ++I+D
Sbjct: 274 QDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 59/260 (22%), Positives = 109/260 (41%), Gaps = 42/260 (16%)

Query: 108 DIVWSLAFGSSVPEKQSRCV----------------------NIEWHRFRFGQDQL---- 141
           D +WS+A+G++  E     V                      ++E H+       +    
Sbjct: 17  DAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTL 76

Query: 142 -LLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDL 200
            + A+   +  I++WD+  GK + ++         L F+PD S  L + +    + ++ +
Sbjct: 77  PIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPD-SQYLATGTHVGKVNIFGV 135

Query: 201 KDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVV 260
            + G     L     ++ S A+SPD   L S      + ++++    ++  LEGH   + 
Sbjct: 136 -ESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIR 194

Query: 261 ACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFS 320
           +  FSPD  LL TAS D  + I+D  + ++               +G A+  WV +V+F 
Sbjct: 195 SLTFSPDSQLLVTASDDGYIKIYDVQHANL-----------AGTLSGHAS--WVLNVAFC 241

Query: 321 HDGLHVASLADDKMVRFWRI 340
            D  H  S + DK V+ W +
Sbjct: 242 PDDTHFVSSSSDKSVKVWDV 261



 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 42/181 (23%), Positives = 79/181 (43%), Gaps = 23/181 (12%)

Query: 204 GNMMKVLRGHQNWVYSCAF------SPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHH 257
           G + K  + H + ++S A+      + ++ +  S+     V+ W  ++  +   LEGH  
Sbjct: 6   GILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQL 65

Query: 258 DVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSV 317
            VV+ D S    + A++S D  + +WD  NG  +                G  D W  ++
Sbjct: 66  GVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSID-----------AGPVDAW--TL 112

Query: 318 SFSHDGLHVASLADDKMVRFWRID---EDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGS 374
           +FS D  ++A+      V  + ++   ++Y +        L  A+S DG  LA+G  DG 
Sbjct: 113 AFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRG-KFILSIAYSPDGKYLASGAIDGI 171

Query: 375 V 375
           +
Sbjct: 172 I 172


>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
            sapiens]
          Length = 1205

 Score = 89.7 bits (221), Expect = 4e-18
 Identities = 87/337 (25%), Positives = 141/337 (41%), Gaps = 42/337 (12%)

Query: 34   GRENWT--VAFAPDGSYFAWSQGHRTVKLVPWSQCLQN------------FLLHGTKNVT 79
            G  +W   V F+PDGS F  S   +T++L    +  +N            F  +    + 
Sbjct: 837  GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 896

Query: 80   NSSSLRLPRQNSDGGQKNKPREHIIDC---GDIVWSLAFG-------------SSVPEKQ 123
                 RL   N   GQ +   E  + C      +  +AFG             + + + +
Sbjct: 897  VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 956

Query: 124  SRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGS 183
             +     WH  +F  D+  L +  ++  I++W+    K +  L  H E V+D     +  
Sbjct: 957  FQHKKTVWH-IQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSR 1014

Query: 184  LILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNM 243
            L+  S S D T++VW++   GN  K    HQ  V SC  S D++   S  A K   +W+ 
Sbjct: 1015 LL--SWSFDGTVKVWNI-ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSF 1071

Query: 244  DKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTP 303
            D    + +L GH+  V    FS D  LLAT   +  + IW+  NG++L    HL  P + 
Sbjct: 1072 DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL----HLCAPLSE 1127

Query: 304  IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRI 340
              A   +  WV  + FS DG  + S      +++W +
Sbjct: 1128 EGA-ATHGGWVTDLCFSPDGKMLISAGG--YIKWWNV 1161



 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 79/286 (27%), Positives = 124/286 (43%), Gaps = 43/286 (15%)

Query: 76  KNVTNSSSLRLPRQNSDGGQK---NKPREHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWH 132
           KN+TN S L + R ++D       ++  + I  CG       F +   EK    + I+ H
Sbjct: 601 KNITNLSRL-VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEK---LLEIKAH 656

Query: 133 RFR-----FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDG-SLIL 186
                   F  D   +AT   + ++KIW+  TG+L+    +H+E V    F      L+L
Sbjct: 657 EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLL 716

Query: 187 VSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLW----- 241
            + S D  L++WDL +       + GH N V  C FSPD  +L S  A   + LW     
Sbjct: 717 ATGSSDCFLKLWDL-NQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSA 775

Query: 242 NMDKYTMIRK----LEGHHHD----VVACDFSPDGALLATASYDTRVYIWDPHNGDILME 293
           N  K   +++    LE    D    V  C +S DGA +  A+   ++++W+  +   + +
Sbjct: 776 NERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSKVAD 834

Query: 294 F-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW 338
             GHL               WV  V FS DG    + +DD+ +R W
Sbjct: 835 CRGHL--------------SWVHGVMFSPDGSSFLTSSDDQTIRLW 866



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 55/193 (28%), Positives = 83/193 (43%), Gaps = 26/193 (13%)

Query: 110 VWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDH 169
           +W+   G  V         +    F      LLLATG ++  +K+WD+   +    +  H
Sbjct: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742

Query: 170 TEVVRDLTFAPDGSLILVSASRDKTLRVWD------------------LKDDGNMMKVLR 211
           T  V    F+PD  L L S S D TL++WD                  L+D    M+V+ 
Sbjct: 743 TNSVNHCRFSPDDKL-LASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI- 800

Query: 212 GHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALL 271
                V  C++S D + +  V A   +FLWN D  + +    GH   V    FSPDG+  
Sbjct: 801 -----VKCCSWSADGARIM-VAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 854

Query: 272 ATASYDTRVYIWD 284
            T+S D  + +W+
Sbjct: 855 LTSSDDQTIRLWE 867



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 69/284 (24%), Positives = 118/284 (41%), Gaps = 19/284 (6%)

Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
           F +D   +A+   +  ++++   TG+ LL +  H + V    F+ D   I  + S DK +
Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFI-ATCSVDKKV 681

Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFL--WNMDKYTMIRKLE 253
           ++W+    G ++     H   V  C F+  S  L     S   FL  W++++      + 
Sbjct: 682 KIWNSMT-GELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMF 740

Query: 254 GHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGD------ILMEFGHLFPPPTPIFAG 307
           GH + V  C FSPD  LLA+ S D  + +WD  + +      +   F +L  P   +   
Sbjct: 741 GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM--- 797

Query: 308 GANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAP--LSNGLCCAFSTDGSV 365
              +  V+  S+S DG  +   A +K+   W  D    V      LS      FS DGS 
Sbjct: 798 ---EVIVKCCSWSADGARIMVAAKNKIF-LWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 853

Query: 366 LAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVMPTQEVQELPI 409
               + D ++  W T +   +   + +  +  V    EV  L +
Sbjct: 854 FLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAV 897



 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 59/230 (25%), Positives = 92/230 (40%), Gaps = 35/230 (15%)

Query: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 228
           HT+ V    F+ DG  I  S   DKTL+V+   + G  +  ++ H++ V  CAFS D   
Sbjct: 614 HTDAVYHACFSEDGQRI-ASCGADKTLQVFKA-ETGEKLLEIKAHEDEVLCCAFSTDDRF 671

Query: 229 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDF--SPDGALLATASYDTRVYIWDPH 286
           + +    K V +WN     ++   + H   V  C F  S    LLAT S D  + +WD +
Sbjct: 672 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 731

Query: 287 NGDIL-MEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW---RIDE 342
             +     FGH                 V    FS D   +AS + D  ++ W     +E
Sbjct: 732 QKECRNTMFGH--------------TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE 777

Query: 343 DYPVQVAPLSNGL------------CCAFSTDGSVLAAGTHDGSVYFWAT 380
              + V      L            CC++S DG+ +     +  ++ W T
Sbjct: 778 RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN-KIFLWNT 826



 Score = 65.5 bits (158), Expect = 9e-11
 Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 17/174 (9%)

Query: 209 VLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDG 268
           V+R H + VY   FS D   + S GA K + ++  +    + +++ H  +V+ C FS D 
Sbjct: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669

Query: 269 ALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLH--V 326
             +AT S D +V IW+   G+++  +               +   V    F++   H  +
Sbjct: 670 RFIATCSVDKKVKIWNSMTGELVHTYDE-------------HSEQVNCCHFTNSSHHLLL 716

Query: 327 ASLADDKMVRFWRID--EDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378
           A+ + D  ++ W ++  E         ++   C FS D  +LA+ + DG++  W
Sbjct: 717 ATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 770


>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
            sapiens]
          Length = 1248

 Score = 89.7 bits (221), Expect = 4e-18
 Identities = 87/337 (25%), Positives = 141/337 (41%), Gaps = 42/337 (12%)

Query: 34   GRENWT--VAFAPDGSYFAWSQGHRTVKLVPWSQCLQN------------FLLHGTKNVT 79
            G  +W   V F+PDGS F  S   +T++L    +  +N            F  +    + 
Sbjct: 880  GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 939

Query: 80   NSSSLRLPRQNSDGGQKNKPREHIIDC---GDIVWSLAFG-------------SSVPEKQ 123
                 RL   N   GQ +   E  + C      +  +AFG             + + + +
Sbjct: 940  VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 999

Query: 124  SRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGS 183
             +     WH  +F  D+  L +  ++  I++W+    K +  L  H E V+D     +  
Sbjct: 1000 FQHKKTVWH-IQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSR 1057

Query: 184  LILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNM 243
            L+  S S D T++VW++   GN  K    HQ  V SC  S D++   S  A K   +W+ 
Sbjct: 1058 LL--SWSFDGTVKVWNI-ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSF 1114

Query: 244  DKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTP 303
            D    + +L GH+  V    FS D  LLAT   +  + IW+  NG++L    HL  P + 
Sbjct: 1115 DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL----HLCAPLSE 1170

Query: 304  IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRI 340
              A   +  WV  + FS DG  + S      +++W +
Sbjct: 1171 EGA-ATHGGWVTDLCFSPDGKMLISAGG--YIKWWNV 1204



 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 66/249 (26%), Positives = 104/249 (41%), Gaps = 42/249 (16%)

Query: 110 VWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDH 169
           +W+   G  V         +    F      LLLATG ++  +K+WD+   +    +  H
Sbjct: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742

Query: 170 TEVVRDLTFAPDGSLILVSASRDKTLRVWD------------------LKDDGNMMKVLR 211
           T  V    F+PD  L L S S D TL++WD                  L+D    M+V+ 
Sbjct: 743 TNSVNHCRFSPDDKL-LASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI- 800

Query: 212 GHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLE-GHHHDVVACDFSPDGAL 270
                V  C++S D + +  V A   +FL+++    ++ ++  GHH  +  CDFSP   L
Sbjct: 801 -----VKCCSWSADGARI-MVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHL 854

Query: 271 LATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASL 329
              A     V +W+  +   + +  GHL               WV  V FS DG    + 
Sbjct: 855 AVVALSQYCVELWNTDSRSKVADCRGHL--------------SWVHGVMFSPDGSSFLTS 900

Query: 330 ADDKMVRFW 338
           +DD+ +R W
Sbjct: 901 SDDQTIRLW 909



 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 46/163 (28%), Positives = 79/163 (48%), Gaps = 15/163 (9%)

Query: 135 RFGQDQLLLATGLNNGRIKIWDVYTG---------KLLLNLVDHTE----VVRDLTFAPD 181
           RF  D  LLA+   +G +K+WD  +          +  LNL D  E    +V+  +++ D
Sbjct: 750 RFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSAD 809

Query: 182 GSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLW 241
           G+ I+V+A     + ++D+   G + ++  GH + +  C FSP + +     +   V LW
Sbjct: 810 GARIMVAAKNK--IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELW 867

Query: 242 NMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 284
           N D  + +    GH   V    FSPDG+   T+S D  + +W+
Sbjct: 868 NTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 910



 Score = 65.5 bits (158), Expect = 9e-11
 Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 17/174 (9%)

Query: 209 VLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDG 268
           V+R H + VY   FS D   + S GA K + ++  +    + +++ H  +V+ C FS D 
Sbjct: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669

Query: 269 ALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLH--V 326
             +AT S D +V IW+   G+++  +               +   V    F++   H  +
Sbjct: 670 RFIATCSVDKKVKIWNSMTGELVHTYDE-------------HSEQVNCCHFTNSSHHLLL 716

Query: 327 ASLADDKMVRFWRID--EDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378
           A+ + D  ++ W ++  E         ++   C FS D  +LA+ + DG++  W
Sbjct: 717 ATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 770



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 57/214 (26%), Positives = 86/214 (40%), Gaps = 34/214 (15%)

Query: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 228
           HT+ V    F+ DG  I  S   DKTL+V+   + G  +  ++ H++ V  CAFS D   
Sbjct: 614 HTDAVYHACFSEDGQRI-ASCGADKTLQVFKA-ETGEKLLEIKAHEDEVLCCAFSTDDRF 671

Query: 229 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDF--SPDGALLATASYDTRVYIWDPH 286
           + +    K V +WN     ++   + H   V  C F  S    LLAT S D  + +WD +
Sbjct: 672 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 731

Query: 287 NGDIL-MEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW---RIDE 342
             +     FGH                 V    FS D   +AS + D  ++ W     +E
Sbjct: 732 QKECRNTMFGH--------------TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE 777

Query: 343 DYPVQVAPLSNGL------------CCAFSTDGS 364
              + V      L            CC++S DG+
Sbjct: 778 RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGA 811



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 26/96 (27%), Positives = 48/96 (50%), Gaps = 3/96 (3%)

Query: 151 RIKIWDVYTGKLLLNL-VDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKV 209
           +I ++D++T  LL  +   H   ++   F+P   L +V+ S+   + +W+  D  + +  
Sbjct: 820 KIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQ-YCVELWNT-DSRSKVAD 877

Query: 210 LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDK 245
            RGH +WV+   FSPD S   +    + + LW   K
Sbjct: 878 CRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKK 913


>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
            sapiens]
          Length = 1194

 Score = 89.7 bits (221), Expect = 4e-18
 Identities = 87/337 (25%), Positives = 141/337 (41%), Gaps = 42/337 (12%)

Query: 34   GRENWT--VAFAPDGSYFAWSQGHRTVKLVPWSQCLQN------------FLLHGTKNVT 79
            G  +W   V F+PDGS F  S   +T++L    +  +N            F  +    + 
Sbjct: 826  GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 885

Query: 80   NSSSLRLPRQNSDGGQKNKPREHIIDC---GDIVWSLAFG-------------SSVPEKQ 123
                 RL   N   GQ +   E  + C      +  +AFG             + + + +
Sbjct: 886  VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 945

Query: 124  SRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGS 183
             +     WH  +F  D+  L +  ++  I++W+    K +  L  H E V+D     +  
Sbjct: 946  FQHKKTVWH-IQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSR 1003

Query: 184  LILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNM 243
            L+  S S D T++VW++   GN  K    HQ  V SC  S D++   S  A K   +W+ 
Sbjct: 1004 LL--SWSFDGTVKVWNI-ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSF 1060

Query: 244  DKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTP 303
            D    + +L GH+  V    FS D  LLAT   +  + IW+  NG++L    HL  P + 
Sbjct: 1061 DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL----HLCAPLSE 1116

Query: 304  IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRI 340
              A   +  WV  + FS DG  + S      +++W +
Sbjct: 1117 EGA-ATHGGWVTDLCFSPDGKMLISAGG--YIKWWNV 1150



 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 79/286 (27%), Positives = 124/286 (43%), Gaps = 43/286 (15%)

Query: 76  KNVTNSSSLRLPRQNSDGGQK---NKPREHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWH 132
           KN+TN S L + R ++D       ++  + I  CG       F +   EK    + I+ H
Sbjct: 590 KNITNLSRL-VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEK---LLEIKAH 645

Query: 133 RFR-----FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDG-SLIL 186
                   F  D   +AT   + ++KIW+  TG+L+    +H+E V    F      L+L
Sbjct: 646 EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLL 705

Query: 187 VSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLW----- 241
            + S D  L++WDL +       + GH N V  C FSPD  +L S  A   + LW     
Sbjct: 706 ATGSSDCFLKLWDL-NQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSA 764

Query: 242 NMDKYTMIRK----LEGHHHD----VVACDFSPDGALLATASYDTRVYIWDPHNGDILME 293
           N  K   +++    LE    D    V  C +S DGA +  A+   ++++W+  +   + +
Sbjct: 765 NERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSKVAD 823

Query: 294 F-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW 338
             GHL               WV  V FS DG    + +DD+ +R W
Sbjct: 824 CRGHL--------------SWVHGVMFSPDGSSFLTSSDDQTIRLW 855



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 55/193 (28%), Positives = 83/193 (43%), Gaps = 26/193 (13%)

Query: 110 VWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDH 169
           +W+   G  V         +    F      LLLATG ++  +K+WD+   +    +  H
Sbjct: 672 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 731

Query: 170 TEVVRDLTFAPDGSLILVSASRDKTLRVWD------------------LKDDGNMMKVLR 211
           T  V    F+PD  L L S S D TL++WD                  L+D    M+V+ 
Sbjct: 732 TNSVNHCRFSPDDKL-LASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI- 789

Query: 212 GHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALL 271
                V  C++S D + +  V A   +FLWN D  + +    GH   V    FSPDG+  
Sbjct: 790 -----VKCCSWSADGARIM-VAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 843

Query: 272 ATASYDTRVYIWD 284
            T+S D  + +W+
Sbjct: 844 LTSSDDQTIRLWE 856



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 69/284 (24%), Positives = 118/284 (41%), Gaps = 19/284 (6%)

Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
           F +D   +A+   +  ++++   TG+ LL +  H + V    F+ D   I  + S DK +
Sbjct: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFI-ATCSVDKKV 670

Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFL--WNMDKYTMIRKLE 253
           ++W+    G ++     H   V  C F+  S  L     S   FL  W++++      + 
Sbjct: 671 KIWNSMT-GELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMF 729

Query: 254 GHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGD------ILMEFGHLFPPPTPIFAG 307
           GH + V  C FSPD  LLA+ S D  + +WD  + +      +   F +L  P   +   
Sbjct: 730 GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM--- 786

Query: 308 GANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAP--LSNGLCCAFSTDGSV 365
              +  V+  S+S DG  +   A +K+   W  D    V      LS      FS DGS 
Sbjct: 787 ---EVIVKCCSWSADGARIMVAAKNKIF-LWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 842

Query: 366 LAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVMPTQEVQELPI 409
               + D ++  W T +   +   + +  +  V    EV  L +
Sbjct: 843 FLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAV 886



 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 59/230 (25%), Positives = 92/230 (40%), Gaps = 35/230 (15%)

Query: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 228
           HT+ V    F+ DG  I  S   DKTL+V+   + G  +  ++ H++ V  CAFS D   
Sbjct: 603 HTDAVYHACFSEDGQRI-ASCGADKTLQVFKA-ETGEKLLEIKAHEDEVLCCAFSTDDRF 660

Query: 229 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDF--SPDGALLATASYDTRVYIWDPH 286
           + +    K V +WN     ++   + H   V  C F  S    LLAT S D  + +WD +
Sbjct: 661 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720

Query: 287 NGDIL-MEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW---RIDE 342
             +     FGH                 V    FS D   +AS + D  ++ W     +E
Sbjct: 721 QKECRNTMFGH--------------TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE 766

Query: 343 DYPVQVAPLSNGL------------CCAFSTDGSVLAAGTHDGSVYFWAT 380
              + V      L            CC++S DG+ +     +  ++ W T
Sbjct: 767 RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN-KIFLWNT 815



 Score = 65.5 bits (158), Expect = 9e-11
 Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 17/174 (9%)

Query: 209 VLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDG 268
           V+R H + VY   FS D   + S GA K + ++  +    + +++ H  +V+ C FS D 
Sbjct: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658

Query: 269 ALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLH--V 326
             +AT S D +V IW+   G+++  +               +   V    F++   H  +
Sbjct: 659 RFIATCSVDKKVKIWNSMTGELVHTYDE-------------HSEQVNCCHFTNSSHHLLL 705

Query: 327 ASLADDKMVRFWRID--EDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378
           A+ + D  ++ W ++  E         ++   C FS D  +LA+ + DG++  W
Sbjct: 706 ATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 759


>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
            sapiens]
          Length = 1237

 Score = 89.7 bits (221), Expect = 4e-18
 Identities = 87/337 (25%), Positives = 141/337 (41%), Gaps = 42/337 (12%)

Query: 34   GRENWT--VAFAPDGSYFAWSQGHRTVKLVPWSQCLQN------------FLLHGTKNVT 79
            G  +W   V F+PDGS F  S   +T++L    +  +N            F  +    + 
Sbjct: 869  GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 928

Query: 80   NSSSLRLPRQNSDGGQKNKPREHIIDC---GDIVWSLAFG-------------SSVPEKQ 123
                 RL   N   GQ +   E  + C      +  +AFG             + + + +
Sbjct: 929  VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 988

Query: 124  SRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGS 183
             +     WH  +F  D+  L +  ++  I++W+    K +  L  H E V+D     +  
Sbjct: 989  FQHKKTVWH-IQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSR 1046

Query: 184  LILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNM 243
            L+  S S D T++VW++   GN  K    HQ  V SC  S D++   S  A K   +W+ 
Sbjct: 1047 LL--SWSFDGTVKVWNI-ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSF 1103

Query: 244  DKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTP 303
            D    + +L GH+  V    FS D  LLAT   +  + IW+  NG++L    HL  P + 
Sbjct: 1104 DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL----HLCAPLSE 1159

Query: 304  IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRI 340
              A   +  WV  + FS DG  + S      +++W +
Sbjct: 1160 EGA-ATHGGWVTDLCFSPDGKMLISAGG--YIKWWNV 1193



 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 66/249 (26%), Positives = 104/249 (41%), Gaps = 42/249 (16%)

Query: 110 VWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDH 169
           +W+   G  V         +    F      LLLATG ++  +K+WD+   +    +  H
Sbjct: 672 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 731

Query: 170 TEVVRDLTFAPDGSLILVSASRDKTLRVWD------------------LKDDGNMMKVLR 211
           T  V    F+PD  L L S S D TL++WD                  L+D    M+V+ 
Sbjct: 732 TNSVNHCRFSPDDKL-LASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI- 789

Query: 212 GHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLE-GHHHDVVACDFSPDGAL 270
                V  C++S D + +  V A   +FL+++    ++ ++  GHH  +  CDFSP   L
Sbjct: 790 -----VKCCSWSADGARI-MVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHL 843

Query: 271 LATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASL 329
              A     V +W+  +   + +  GHL               WV  V FS DG    + 
Sbjct: 844 AVVALSQYCVELWNTDSRSKVADCRGHL--------------SWVHGVMFSPDGSSFLTS 889

Query: 330 ADDKMVRFW 338
           +DD+ +R W
Sbjct: 890 SDDQTIRLW 898



 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 46/163 (28%), Positives = 79/163 (48%), Gaps = 15/163 (9%)

Query: 135 RFGQDQLLLATGLNNGRIKIWDVYTG---------KLLLNLVDHTE----VVRDLTFAPD 181
           RF  D  LLA+   +G +K+WD  +          +  LNL D  E    +V+  +++ D
Sbjct: 739 RFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSAD 798

Query: 182 GSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLW 241
           G+ I+V+A     + ++D+   G + ++  GH + +  C FSP + +     +   V LW
Sbjct: 799 GARIMVAAKNK--IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELW 856

Query: 242 NMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 284
           N D  + +    GH   V    FSPDG+   T+S D  + +W+
Sbjct: 857 NTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 899



 Score = 65.5 bits (158), Expect = 9e-11
 Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 17/174 (9%)

Query: 209 VLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDG 268
           V+R H + VY   FS D   + S GA K + ++  +    + +++ H  +V+ C FS D 
Sbjct: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658

Query: 269 ALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLH--V 326
             +AT S D +V IW+   G+++  +               +   V    F++   H  +
Sbjct: 659 RFIATCSVDKKVKIWNSMTGELVHTYDE-------------HSEQVNCCHFTNSSHHLLL 705

Query: 327 ASLADDKMVRFWRID--EDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378
           A+ + D  ++ W ++  E         ++   C FS D  +LA+ + DG++  W
Sbjct: 706 ATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 759



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 57/214 (26%), Positives = 86/214 (40%), Gaps = 34/214 (15%)

Query: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 228
           HT+ V    F+ DG  I  S   DKTL+V+   + G  +  ++ H++ V  CAFS D   
Sbjct: 603 HTDAVYHACFSEDGQRI-ASCGADKTLQVFKA-ETGEKLLEIKAHEDEVLCCAFSTDDRF 660

Query: 229 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDF--SPDGALLATASYDTRVYIWDPH 286
           + +    K V +WN     ++   + H   V  C F  S    LLAT S D  + +WD +
Sbjct: 661 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720

Query: 287 NGDIL-MEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW---RIDE 342
             +     FGH                 V    FS D   +AS + D  ++ W     +E
Sbjct: 721 QKECRNTMFGH--------------TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE 766

Query: 343 DYPVQVAPLSNGL------------CCAFSTDGS 364
              + V      L            CC++S DG+
Sbjct: 767 RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGA 800



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 26/96 (27%), Positives = 48/96 (50%), Gaps = 3/96 (3%)

Query: 151 RIKIWDVYTGKLLLNL-VDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKV 209
           +I ++D++T  LL  +   H   ++   F+P   L +V+ S+   + +W+  D  + +  
Sbjct: 809 KIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQ-YCVELWNT-DSRSKVAD 866

Query: 210 LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDK 245
            RGH +WV+   FSPD S   +    + + LW   K
Sbjct: 867 CRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKK 902


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 89.0 bits (219), Expect = 7e-18
 Identities = 78/271 (28%), Positives = 114/271 (42%), Gaps = 44/271 (16%)

Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198
           D  L+A G  +  +++W V   KL           R +  A D SLI    S D   R+ 
Sbjct: 481 DSSLIAGGFADSTVRVWSVTPKKL-----------RSVKQASDLSLI-DKESDDVLERIM 528

Query: 199 DLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHD 258
           D K   + +K+L GH   VY  +FSPD + L S      V LW++  +T +   +GH++ 
Sbjct: 529 DEKT-ASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYP 587

Query: 259 VVACDFSPDGALLATASYDTRVYIW-DPHNGDILMEFGHL-------FPPPTPIFAGGAN 310
           V    FSP G    +  +D    +W   H   + +  GHL       F P +   A G+ 
Sbjct: 588 VWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSA 647

Query: 311 DRWVR---------------------SVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVA 349
           DR VR                     S++FS +G  +A+ A D  V  W I     V   
Sbjct: 648 DRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL 707

Query: 350 PLSNGLCCA--FSTDGSVLAAGTHDGSVYFW 378
                  C+  FS DG +LA+G+ D +V  W
Sbjct: 708 KGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738



 Score = 85.5 bits (210), Expect = 8e-17
 Identities = 60/204 (29%), Positives = 93/204 (45%), Gaps = 17/204 (8%)

Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
           F  D+  L +   +G +++W + T   L+    H   V D  F+P G    VS   D+  
Sbjct: 551 FSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYG-YYFVSGGHDRVA 609

Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
           R+W   D    +++  GH   V    F P+S+ + +  A + V LW++     +R   GH
Sbjct: 610 RLW-ATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGH 668

Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWV 314
              + +  FSP+G  LAT + D RV +WD  +G ++ E  GH                 V
Sbjct: 669 KGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGH--------------TDTV 714

Query: 315 RSVSFSHDGLHVASLADDKMVRFW 338
            S+ FS DG  +AS + D  VR W
Sbjct: 715 CSLRFSRDGEILASGSMDNTVRLW 738



 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 35/111 (31%), Positives = 55/111 (49%), Gaps = 2/111 (1%)

Query: 135 RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKT 194
           RF  +   +ATG  +  +++WDV  G  +     H   +  LTF+P+G  +   A+  + 
Sbjct: 634 RFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRV 693

Query: 195 LRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDK 245
           L +WD+   G M+  L+GH + V S  FS D  +L S      V LW+  K
Sbjct: 694 L-LWDI-GHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIK 742



 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 28/68 (41%), Positives = 39/68 (57%), Gaps = 1/68 (1%)

Query: 132 HRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASR 191
           H   F  +   LATG  +GR+ +WD+  G ++  L  HT+ V  L F+ DG  IL S S 
Sbjct: 673 HSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGE-ILASGSM 731

Query: 192 DKTLRVWD 199
           D T+R+WD
Sbjct: 732 DNTVRLWD 739



 Score = 30.8 bits (68), Expect = 2.4
 Identities = 39/170 (22%), Positives = 57/170 (33%), Gaps = 44/170 (25%)

Query: 246 YTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIW-------------------DPH 286
           YT +   +G    + A D + D +L+A    D+ V +W                   D  
Sbjct: 464 YTFLNAYQG----LTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKE 519

Query: 287 NGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRID---- 341
           + D+L             I  G +    V   SFS D  ++ S ++D  VR W +     
Sbjct: 520 SDDVLERIMDEKTASELKILYGHSGP--VYGASFSPDRNYLLSSSEDGTVRLWSLQTFTC 577

Query: 342 ------EDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVP 385
                  +YPV            FS  G    +G HD     WAT    P
Sbjct: 578 LVGYKGHNYPVWDTQ--------FSPYGYYFVSGGHDRVARLWATDHYQP 619



 Score = 30.4 bits (67), Expect = 3.1
 Identities = 34/160 (21%), Positives = 61/160 (38%), Gaps = 18/160 (11%)

Query: 42  FAPDGSYFAWSQGHRTVKL--VPWSQCLQNFLLHG--TKNVTNSSSLRLPRQNSDGGQKN 97
           F P+ +Y A     RTV+L  V    C++ F  H     ++T S + R     +  G+  
Sbjct: 635 FHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRV- 693

Query: 98  KPREHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDV 157
                      ++W +  G  V E +     +     RF +D  +LA+G  +  +++WD 
Sbjct: 694 -----------LLWDIGHGLMVGELKGHTDTV--CSLRFSRDGEILASGSMDNTVRLWDA 740

Query: 158 YTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRV 197
                 L   D T     +    +   +L+     K+  V
Sbjct: 741 IKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPV 780


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 54/174 (31%), Positives = 84/174 (48%), Gaps = 17/174 (9%)

Query: 166 LVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPD 225
           L  H   V  + F P  S ++VSAS D T++VWD  + G+  + L+GH + V   +F   
Sbjct: 104 LSGHRSPVTRVIFHPVFS-VMVSASEDATIKVWDY-ETGDFERTLKGHTDSVQDISFDHS 161

Query: 226 SSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDP 285
             +L S  A   + LW+   +  IR + GH H+V +    P+G  + +AS D  + +W+ 
Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEV 221

Query: 286 HNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW 338
             G  +  F GH                WVR V  + DG  +AS ++D+ VR W
Sbjct: 222 QTGYCVKTFTGH--------------REWVRMVRPNQDGTLIASCSNDQTVRVW 261



 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 62/224 (27%), Positives = 94/224 (41%), Gaps = 37/224 (16%)

Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
           F     LLA+   +  IK+WD    + +  +  H   V  +   P+G  I VSASRDKT+
Sbjct: 158 FDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHI-VSASRDKTI 216

Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
           ++W+++  G  +K   GH+ WV     + D +++ S    + V +W +       +L  H
Sbjct: 217 KMWEVQT-GYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREH 275

Query: 256 HHDVVACDFSPD--------------------GALLATASYDTRVYIWDPHNGDILMEF- 294
            H V    ++P+                    G  L + S D  + +WD   G  LM   
Sbjct: 276 EHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLV 335

Query: 295 GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW 338
           GH              D WVR V F   G  + S ADDK +R W
Sbjct: 336 GH--------------DNWVRGVLFHSGGKFILSCADDKTLRVW 365



 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 50/175 (28%), Positives = 78/175 (44%), Gaps = 21/175 (12%)

Query: 130 EWHRF-RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSL---- 184
           EW R  R  QD  L+A+  N+  +++W V T +    L +H  VV  +++AP+ S     
Sbjct: 235 EWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSIS 294

Query: 185 ---------------ILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSML 229
                           L+S SRDKT+++WD+   G  +  L GH NWV    F      +
Sbjct: 295 EATGSETKKSGKPGPFLLSGSRDKTIKMWDVST-GMCLMTLVGHDNWVRGVLFHSGGKFI 353

Query: 230 CSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 284
            S    K + +W+      ++ L  H H V + DF      + T S D  V +W+
Sbjct: 354 LSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408



 Score = 59.3 bits (142), Expect = 6e-09
 Identities = 43/172 (25%), Positives = 73/172 (42%), Gaps = 17/172 (9%)

Query: 210 LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGA 269
           L GH++ V    F P  S++ S      + +W+ +     R L+GH   V    F   G 
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163

Query: 270 LLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVAS 328
           LLA+ S D  + +WD    + +    GH              D  V SV+   +G H+ S
Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGH--------------DHNVSSVAIMPNGDHIVS 209

Query: 329 LADDKMVRFWRIDEDYPVQVAPLSNGLCCAF--STDGSVLAAGTHDGSVYFW 378
            + DK ++ W +   Y V+              + DG+++A+ ++D +V  W
Sbjct: 210 ASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 261



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 50/207 (24%), Positives = 85/207 (41%), Gaps = 35/207 (16%)

Query: 152 IKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLR 211
           IK+W+V TG  +     H E VR +    DG+LI  S S D+T+RVW +         LR
Sbjct: 216 IKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLI-ASCSNDQTVRVWVVATK-ECKAELR 273

Query: 212 GHQNWVYSCAFSPDSS--------------------MLCSVGASKAVFLWNMDKYTMIRK 251
            H++ V   +++P+SS                     L S    K + +W++     +  
Sbjct: 274 EHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMT 333

Query: 252 LEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGAND 311
           L GH + V    F   G  + + + D  + +WD  N   +                 A++
Sbjct: 334 LVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTL-------------NAHE 380

Query: 312 RWVRSVSFSHDGLHVASLADDKMVRFW 338
            +V S+ F     +V + + D+ V+ W
Sbjct: 381 HFVTSLDFHKTAPYVVTGSVDQTVKVW 407


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 48/147 (32%), Positives = 78/147 (53%), Gaps = 2/147 (1%)

Query: 141 LLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDL 200
           L  A+G ++   ++W       L     H   V  + F P+ +  L + S DKT+R+W  
Sbjct: 397 LYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNY-LATGSTDKTVRLWSA 455

Query: 201 KDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVV 260
           +  GN +++  GH+  V S AFSP+   L S G  + + LW++   T+ ++L GH  ++ 
Sbjct: 456 QQ-GNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNIT 514

Query: 261 ACDFSPDGALLATASYDTRVYIWDPHN 287
           +  FSPD  L+A+AS D  V +WD  N
Sbjct: 515 SLTFSPDSGLIASASMDNSVRVWDIRN 541



 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 75/273 (27%), Positives = 111/273 (40%), Gaps = 47/273 (17%)

Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198
           D  LLA G +N  IK+W + + KL      H   V  +  A D             L   
Sbjct: 279 DSKLLAAGFDNSCIKLWSLRSKKLKSE--PHQVDVSRIHLACD------------ILEEE 324

Query: 199 DLKDD--GNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHH 256
           D +DD  G  MK+LRGH   VYS  F  DSS L S     ++  W++  +T     +GH 
Sbjct: 325 DDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHA 384

Query: 257 HDVVACDFSPDGALLATASYDTRVYIWD-PHNGDILMEFGHL-------FPPPTPIFAGG 308
           + V   D SP     A+ S+D    +W       + +  GHL       F P +   A G
Sbjct: 385 YPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATG 444

Query: 309 ANDRWVR---------------------SVSFSHDGLHVASLADDKMVRFWRIDED--YP 345
           + D+ VR                     S++FS +G ++AS  +D+ ++ W +     Y 
Sbjct: 445 STDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYK 504

Query: 346 VQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378
                  N     FS D  ++A+ + D SV  W
Sbjct: 505 ELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537



 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 63/210 (30%), Positives = 94/210 (44%), Gaps = 15/210 (7%)

Query: 135 RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKT 194
           RF  D   L +   +  I+ WD+ +    +    H   V DL  +P  SL   S S D+T
Sbjct: 349 RFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPY-SLYFASGSHDRT 407

Query: 195 LRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEG 254
            R+W   D    +++  GH   V    F P+S+ L +    K V LW+  +   +R   G
Sbjct: 408 ARLWSF-DRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTG 466

Query: 255 HHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWV 314
           H   V++  FSP+G  LA+A  D R+ +WD  +G +  E              G  D  +
Sbjct: 467 HRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL------------RGHTDN-I 513

Query: 315 RSVSFSHDGLHVASLADDKMVRFWRIDEDY 344
            S++FS D   +AS + D  VR W I   Y
Sbjct: 514 TSLTFSPDSGLIASASMDNSVRVWDIRNTY 543


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 86.3 bits (212), Expect = 5e-17
 Identities = 62/209 (29%), Positives = 93/209 (44%), Gaps = 17/209 (8%)

Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
           F  D     T  ++  +K+W  +  K L +L  H   VR   F+PDG LI VSAS DKT+
Sbjct: 73  FCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLI-VSASDDKTV 131

Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
           ++WD K     +     H  +V    F P  + + + G    V +W++  + +++  + H
Sbjct: 132 KLWD-KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLH 190

Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWV 314
              V    F P G  L TAS D+ + I D   G +L    GH  P  T            
Sbjct: 191 SAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATT------------ 238

Query: 315 RSVSFSHDGLHVASLADDKMVRFWRIDED 343
             V+FS  G + AS   D+ V  W+ + D
Sbjct: 239 --VAFSRTGEYFASGGSDEQVMVWKSNFD 265



 Score = 82.0 bits (201), Expect = 9e-16
 Identities = 69/263 (26%), Positives = 98/263 (37%), Gaps = 22/263 (8%)

Query: 123 QSRCVNIEWHR-----FRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLT 177
           QSR      H+       F     LLA+G  +  ++IW             HT  VR + 
Sbjct: 13  QSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVH 72

Query: 178 FAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKA 237
           F  DG    V+AS DKT++VW       +   L  H NWV    FSPD  ++ S    K 
Sbjct: 73  FCSDGQSF-VTASDDKTVKVWATHRQKFLFS-LSQHINWVRCAKFSPDGRLIVSASDDKT 130

Query: 238 VFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHL 297
           V LW+      +     H   V   DF P G  +A A  D  V +WD     +L  +   
Sbjct: 131 VKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY--- 187

Query: 298 FPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--L 355
                       +   V  +SF   G ++ + + D  ++   + E   +       G   
Sbjct: 188 ----------QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 237

Query: 356 CCAFSTDGSVLAAGTHDGSVYFW 378
             AFS  G   A+G  D  V  W
Sbjct: 238 TVAFSRTGEYFASGGSDEQVMVW 260



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 42/143 (29%), Positives = 66/143 (46%), Gaps = 15/143 (10%)

Query: 238 VFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHL 297
           + +W+M   +   +  GH   V   +FSP G LLA+ S D  V IW P+           
Sbjct: 5   LMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPN----------- 53

Query: 298 FPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRID-EDYPVQVAPLSNGLC 356
               + +F   A+   VRSV F  DG    + +DDK V+ W    + +   ++   N + 
Sbjct: 54  VKGESTVFR--AHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVR 111

Query: 357 CA-FSTDGSVLAAGTHDGSVYFW 378
           CA FS DG ++ + + D +V  W
Sbjct: 112 CAKFSPDGRLIVSASDDKTVKLW 134



 Score = 33.9 bits (76), Expect = 0.28
 Identities = 24/72 (33%), Positives = 33/72 (45%), Gaps = 2/72 (2%)

Query: 314 VRSVSFSHDGLHVASLADDKMVRFW--RIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTH 371
           V  V+FS  G  +AS + DK VR W   +  +  V  A  +      F +DG      + 
Sbjct: 26  VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 85

Query: 372 DGSVYFWATPRQ 383
           D +V  WAT RQ
Sbjct: 86  DKTVKVWATHRQ 97


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 86.3 bits (212), Expect = 5e-17
 Identities = 62/209 (29%), Positives = 93/209 (44%), Gaps = 17/209 (8%)

Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
           F  D     T  ++  +K+W  +  K L +L  H   VR   F+PDG LI VSAS DKT+
Sbjct: 111 FCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLI-VSASDDKTV 169

Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
           ++WD K     +     H  +V    F P  + + + G    V +W++  + +++  + H
Sbjct: 170 KLWD-KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLH 228

Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWV 314
              V    F P G  L TAS D+ + I D   G +L    GH  P  T            
Sbjct: 229 SAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATT------------ 276

Query: 315 RSVSFSHDGLHVASLADDKMVRFWRIDED 343
             V+FS  G + AS   D+ V  W+ + D
Sbjct: 277 --VAFSRTGEYFASGGSDEQVMVWKSNFD 303



 Score = 82.0 bits (201), Expect = 9e-16
 Identities = 69/263 (26%), Positives = 98/263 (37%), Gaps = 22/263 (8%)

Query: 123 QSRCVNIEWHR-----FRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLT 177
           QSR      H+       F     LLA+G  +  ++IW             HT  VR + 
Sbjct: 51  QSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVH 110

Query: 178 FAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKA 237
           F  DG    V+AS DKT++VW       +   L  H NWV    FSPD  ++ S    K 
Sbjct: 111 FCSDGQSF-VTASDDKTVKVWATHRQKFLFS-LSQHINWVRCAKFSPDGRLIVSASDDKT 168

Query: 238 VFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHL 297
           V LW+      +     H   V   DF P G  +A A  D  V +WD     +L  +   
Sbjct: 169 VKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY--- 225

Query: 298 FPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--L 355
                       +   V  +SF   G ++ + + D  ++   + E   +       G   
Sbjct: 226 ----------QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 275

Query: 356 CCAFSTDGSVLAAGTHDGSVYFW 378
             AFS  G   A+G  D  V  W
Sbjct: 276 TVAFSRTGEYFASGGSDEQVMVW 298



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 65/238 (27%), Positives = 100/238 (42%), Gaps = 23/238 (9%)

Query: 143 LATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKD 202
           LA+G  +  + +W +           H + V  + F+P G L L S SRDKT+R+W    
Sbjct: 34  LASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL-LASGSRDKTVRIWVPNV 92

Query: 203 DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVAC 262
            G    V R H   V S  F  D     +    K V +W   +   +  L  H + V   
Sbjct: 93  KGE-STVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCA 151

Query: 263 DFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHD 322
            FSPDG L+ +AS D  V +WD  + + +  +            GG    +V  V F   
Sbjct: 152 KFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE---------HGG----FVTYVDFHPS 198

Query: 323 GLHVASLADDKMVRFW-----RIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSV 375
           G  +A+   D  V+ W     R+ + Y +  A + NGL  +F   G+ L   + D ++
Sbjct: 199 GTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAV-NGL--SFHPSGNYLITASSDSTL 253



 Score = 73.2 bits (178), Expect = 4e-13
 Identities = 50/179 (27%), Positives = 83/179 (46%), Gaps = 15/179 (8%)

Query: 202 DDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVA 261
           +D ++ +  +GH++ V    FS ++  L S      + +W+M   +   +  GH   V  
Sbjct: 7   EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66

Query: 262 CDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSH 321
            +FSP G LLA+ S D  V IW P+               + +F   A+   VRSV F  
Sbjct: 67  VNFSPSGHLLASGSRDKTVRIWVPN-----------VKGESTVFR--AHTATVRSVHFCS 113

Query: 322 DGLHVASLADDKMVRFWRID-EDYPVQVAPLSNGLCCA-FSTDGSVLAAGTHDGSVYFW 378
           DG    + +DDK V+ W    + +   ++   N + CA FS DG ++ + + D +V  W
Sbjct: 114 DGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 40/136 (29%), Positives = 56/136 (41%), Gaps = 15/136 (11%)

Query: 250 RKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGA 309
           R  +GH   V   DFS +   LA+ S D+ + +W            H+ P        G 
Sbjct: 13  RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVW------------HMKPQSRAYRFTGH 60

Query: 310 NDRWVRSVSFSHDGLHVASLADDKMVRFW--RIDEDYPVQVAPLSNGLCCAFSTDGSVLA 367
            D  V  V+FS  G  +AS + DK VR W   +  +  V  A  +      F +DG    
Sbjct: 61  KDA-VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 119

Query: 368 AGTHDGSVYFWATPRQ 383
             + D +V  WAT RQ
Sbjct: 120 TASDDKTVKVWATHRQ 135


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 86.3 bits (212), Expect = 5e-17
 Identities = 62/209 (29%), Positives = 93/209 (44%), Gaps = 17/209 (8%)

Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
           F  D     T  ++  +K+W  +  K L +L  H   VR   F+PDG LI VSAS DKT+
Sbjct: 111 FCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLI-VSASDDKTV 169

Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
           ++WD K     +     H  +V    F P  + + + G    V +W++  + +++  + H
Sbjct: 170 KLWD-KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLH 228

Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWV 314
              V    F P G  L TAS D+ + I D   G +L    GH  P  T            
Sbjct: 229 SAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATT------------ 276

Query: 315 RSVSFSHDGLHVASLADDKMVRFWRIDED 343
             V+FS  G + AS   D+ V  W+ + D
Sbjct: 277 --VAFSRTGEYFASGGSDEQVMVWKSNFD 303



 Score = 82.0 bits (201), Expect = 9e-16
 Identities = 69/263 (26%), Positives = 98/263 (37%), Gaps = 22/263 (8%)

Query: 123 QSRCVNIEWHR-----FRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLT 177
           QSR      H+       F     LLA+G  +  ++IW             HT  VR + 
Sbjct: 51  QSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVH 110

Query: 178 FAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKA 237
           F  DG    V+AS DKT++VW       +   L  H NWV    FSPD  ++ S    K 
Sbjct: 111 FCSDGQSF-VTASDDKTVKVWATHRQKFLFS-LSQHINWVRCAKFSPDGRLIVSASDDKT 168

Query: 238 VFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHL 297
           V LW+      +     H   V   DF P G  +A A  D  V +WD     +L  +   
Sbjct: 169 VKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY--- 225

Query: 298 FPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--L 355
                       +   V  +SF   G ++ + + D  ++   + E   +       G   
Sbjct: 226 ----------QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 275

Query: 356 CCAFSTDGSVLAAGTHDGSVYFW 378
             AFS  G   A+G  D  V  W
Sbjct: 276 TVAFSRTGEYFASGGSDEQVMVW 298



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 65/238 (27%), Positives = 100/238 (42%), Gaps = 23/238 (9%)

Query: 143 LATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKD 202
           LA+G  +  + +W +           H + V  + F+P G L L S SRDKT+R+W    
Sbjct: 34  LASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL-LASGSRDKTVRIWVPNV 92

Query: 203 DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVAC 262
            G    V R H   V S  F  D     +    K V +W   +   +  L  H + V   
Sbjct: 93  KGE-STVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCA 151

Query: 263 DFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHD 322
            FSPDG L+ +AS D  V +WD  + + +  +            GG    +V  V F   
Sbjct: 152 KFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE---------HGG----FVTYVDFHPS 198

Query: 323 GLHVASLADDKMVRFW-----RIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSV 375
           G  +A+   D  V+ W     R+ + Y +  A + NGL  +F   G+ L   + D ++
Sbjct: 199 GTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAV-NGL--SFHPSGNYLITASSDSTL 253



 Score = 73.2 bits (178), Expect = 4e-13
 Identities = 50/179 (27%), Positives = 83/179 (46%), Gaps = 15/179 (8%)

Query: 202 DDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVA 261
           +D ++ +  +GH++ V    FS ++  L S      + +W+M   +   +  GH   V  
Sbjct: 7   EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66

Query: 262 CDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSH 321
            +FSP G LLA+ S D  V IW P+               + +F   A+   VRSV F  
Sbjct: 67  VNFSPSGHLLASGSRDKTVRIWVPN-----------VKGESTVFR--AHTATVRSVHFCS 113

Query: 322 DGLHVASLADDKMVRFWRID-EDYPVQVAPLSNGLCCA-FSTDGSVLAAGTHDGSVYFW 378
           DG    + +DDK V+ W    + +   ++   N + CA FS DG ++ + + D +V  W
Sbjct: 114 DGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 40/136 (29%), Positives = 56/136 (41%), Gaps = 15/136 (11%)

Query: 250 RKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGA 309
           R  +GH   V   DFS +   LA+ S D+ + +W            H+ P        G 
Sbjct: 13  RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVW------------HMKPQSRAYRFTGH 60

Query: 310 NDRWVRSVSFSHDGLHVASLADDKMVRFW--RIDEDYPVQVAPLSNGLCCAFSTDGSVLA 367
            D  V  V+FS  G  +AS + DK VR W   +  +  V  A  +      F +DG    
Sbjct: 61  KDA-VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 119

Query: 368 AGTHDGSVYFWATPRQ 383
             + D +V  WAT RQ
Sbjct: 120 TASDDKTVKVWATHRQ 135


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 71/241 (29%), Positives = 109/241 (45%), Gaps = 28/241 (11%)

Query: 152 IKIWDVYTG-KLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVL 210
           I +W+VY        L  H+  V +L +  DGS+ L SAS DKT+ VWD  + G  +K L
Sbjct: 90  ILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM-LFSASTDKTVAVWD-SETGERVKRL 147

Query: 211 RGHQNWVYSCAFSPDSSMLCSVGASKA-VFLWNMDKYTMIRKLEGHHHDVVACDFSPDGA 269
           +GH ++V SC  +     L   G+    V LW++ K   I+  + + + V+A  F+    
Sbjct: 148 KGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSD 206

Query: 270 LLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASL 329
            + +   D  + +WD     +           T    G A+   V  +S S +G ++ S 
Sbjct: 207 QIISGGIDNDIKVWDLRQNKL-----------TYTMRGHADS--VTGLSLSSEGSYLLSN 253

Query: 330 ADDKMVRFWRIDEDYPVQVAPL----------SNGLCCAFSTDGSVLAAGTHDGSVYFWA 379
           A D  VR W +    P +               N L C++S DGS +AAG+ D  VY W 
Sbjct: 254 AMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWD 313

Query: 380 T 380
           T
Sbjct: 314 T 314



 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 43/148 (29%), Positives = 81/148 (54%), Gaps = 9/148 (6%)

Query: 142 LLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLK 201
           +++ G++N  IK+WD+   KL   +  H + V  L+ + +GS +L +A  D T+RVWD++
Sbjct: 208 IISGGIDND-IKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAM-DNTVRVWDVR 265

Query: 202 DDGNMMKVLRGHQNWVYS-------CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEG 254
                 + ++  Q  V++       C++SPD S + +  A + V++W+     ++ KL G
Sbjct: 266 PFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPG 325

Query: 255 HHHDVVACDFSPDGALLATASYDTRVYI 282
           H   +    F PD  ++ +AS D R+Y+
Sbjct: 326 HAGSINEVAFHPDEPIIISASSDKRLYM 353



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 55/251 (21%), Positives = 104/251 (41%), Gaps = 25/251 (9%)

Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
           +  D  +L +   +  + +WD  TG+ +  L  HT  V     A  G  ++ + S D T+
Sbjct: 117 YNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTV 176

Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
           ++WD++    +      +Q  V +  F+  S  + S G    + +W++ +  +   + GH
Sbjct: 177 KLWDIRKKAAIQTFQNTYQ--VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGH 234

Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPP---TPIFAGGAN-- 310
              V     S +G+ L + + D  V +WD             F P      IF G  +  
Sbjct: 235 ADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRP----------FAPKERCVKIFQGNVHNF 284

Query: 311 DRWVRSVSFSHDGLHVASLADDKMVRFW-----RIDEDYPVQVAPLSNGLCCAFSTDGSV 365
           ++ +   S+S DG  +A+ + D+ V  W     RI    P     ++     AF  D  +
Sbjct: 285 EKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINE---VAFHPDEPI 341

Query: 366 LAAGTHDGSVY 376
           + + + D  +Y
Sbjct: 342 IISASSDKRLY 352



 Score = 35.4 bits (80), Expect = 0.098
 Identities = 19/69 (27%), Positives = 36/69 (52%), Gaps = 1/69 (1%)

Query: 133 RFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRD 192
           R  +  D   +A G  +  + +WD  + ++L  L  H   + ++ F PD   I++SAS D
Sbjct: 290 RCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPD-EPIIISASSD 348

Query: 193 KTLRVWDLK 201
           K L + +++
Sbjct: 349 KRLYMGEIQ 357


>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
           [Homo sapiens]
          Length = 340

 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 65/256 (25%), Positives = 110/256 (42%), Gaps = 22/256 (8%)

Query: 132 HRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASR 191
           +   +G D  LL +   +G++ IWD YT   +  +   +  V    +AP G+ +      
Sbjct: 59  YAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYV-ACGGL 117

Query: 192 DKTLRVWDLKD-DGN--MMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTM 248
           D    +++LK  +GN  + + L GH  ++  C F  DS ++ S G +    LW+++    
Sbjct: 118 DNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCA-LWDIETAQQ 176

Query: 249 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGG 308
                GH  DV++   SPD     + + D    +WD  +G                F G 
Sbjct: 177 TTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQS-----------FTGH 225

Query: 309 ANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLC----CAFSTDGS 364
            +D  + +VSF  +G   A+ +DD   R + +  D  + +    N +C     AFS  G 
Sbjct: 226 VSD--INAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGR 283

Query: 365 VLAAGTHDGSVYFWAT 380
           +L AG  D +   W T
Sbjct: 284 LLLAGYDDFNCNVWDT 299



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 39/149 (26%), Positives = 66/149 (44%), Gaps = 6/149 (4%)

Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198
           D     +G  +   K+WD+  G    +   H   +  ++F P+G     + S D T R++
Sbjct: 195 DMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNG-YAFATGSDDATCRLF 253

Query: 199 DLKDDGNMMKVLRGHQN---WVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
           DL+ D  ++  L  H N    + S AFS    +L +        +W+  K      L GH
Sbjct: 254 DLRADQELL--LYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGH 311

Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWD 284
            + V     + DG  +AT S+D+ + IW+
Sbjct: 312 DNRVSCLGVTDDGMAVATGSWDSFLRIWN 340



 Score = 37.7 bits (86), Expect = 0.020
 Identities = 34/141 (24%), Positives = 54/141 (38%), Gaps = 30/141 (21%)

Query: 242 NMDKYTMI-----RKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGH 296
           NMD    I     R L GH   + A  +  D  LL +AS D ++ IWD +  + +    H
Sbjct: 36  NMDSVGRIQMRTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKM----H 91

Query: 297 LFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW---------RIDEDYPVQ 347
             P             WV + +++  G +VA    D +   +         R+  + P  
Sbjct: 92  AIP---------LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGH 142

Query: 348 VAPLSNGLCCAFSTDGSVLAA 368
              LS   CC F  D  ++ +
Sbjct: 143 TGYLS---CCRFLDDSQIVTS 160



 Score = 29.6 bits (65), Expect = 5.4
 Identities = 18/64 (28%), Positives = 27/64 (42%), Gaps = 1/64 (1%)

Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
           F +   LL  G ++    +WD   G     L  H   V  L    DG + + + S D  L
Sbjct: 278 FSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDG-MAVATGSWDSFL 336

Query: 196 RVWD 199
           R+W+
Sbjct: 337 RIWN 340


>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
          Length = 943

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 48/158 (30%), Positives = 82/158 (51%), Gaps = 2/158 (1%)

Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
           +  +Q LLA  L +  +KI+ V T K  L+L  H   V  +  + DG+LI  + S D+ +
Sbjct: 557 YSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALI-ATGSADRNV 615

Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
           ++W L D G+  K L  H + V    F P S +  + G    +  W+ DK+  I+ LEGH
Sbjct: 616 KIWGL-DFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGH 674

Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILME 293
           H ++     SP G  + ++S+D  + +W+     +++E
Sbjct: 675 HQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILE 712



 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 62/250 (24%), Positives = 106/250 (42%), Gaps = 26/250 (10%)

Query: 146 GLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWD---LKD 202
           G   G+++++D+ +G LL  +  H   +  ++ +PD     V+   DK+++ WD   +KD
Sbjct: 472 GTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPD-QRGFVTGGADKSVKFWDFELVKD 530

Query: 203 DGNMMKVLRGHQNW-------VYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
           + +  K L   Q         V   ++SP+  +L        V ++ +D       L GH
Sbjct: 531 ENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGH 590

Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVR 315
              V+  D S DGAL+AT S D  V IW    GD              +FA   +  +++
Sbjct: 591 KLPVICMDISHDGALIATGSADRNVKIWGLDFGDC----------HKSLFAHDDSVMYLQ 640

Query: 316 SVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDG 373
            V  SH      +   D  ++ W  D+   +Q     +    C A S  G  + + +HD 
Sbjct: 641 FVPKSH---LFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDK 697

Query: 374 SVYFWATPRQ 383
           S+  W   R+
Sbjct: 698 SLRLWERTRE 707



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 36/146 (24%), Positives = 70/146 (47%), Gaps = 2/146 (1%)

Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198
           D L LA G  +G I+I+ + +G+  +    H   +  L +   G   L S S+D  + VW
Sbjct: 76  DGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGR-LASGSKDTDIIVW 134

Query: 199 DLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHD 258
           D+ ++  + + L+GH++ +    F  + ++L + G    V  W++D     + + GH  +
Sbjct: 135 DVINESGLYR-LKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTE 193

Query: 259 VVACDFSPDGALLATASYDTRVYIWD 284
           V       +   L T + D+ + +WD
Sbjct: 194 VWGLVLLSEEKRLITGASDSELRVWD 219



 Score = 52.4 bits (124), Expect = 8e-07
 Identities = 33/115 (28%), Positives = 53/115 (46%), Gaps = 2/115 (1%)

Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198
           D  L+ATG  +  +KIW +  G    +L  H + V  L F P   L   +A +D  ++ W
Sbjct: 602 DGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFF-TAGKDHKIKQW 660

Query: 199 DLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLE 253
           D  D    ++ L GH   ++  A SP    + S    K++ LW   +  +I + E
Sbjct: 661 DA-DKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILEEE 714



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 35/132 (26%), Positives = 61/132 (46%), Gaps = 4/132 (3%)

Query: 154 IWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWD-LKDDGNMMKVLRG 212
           IWD+  G+ +L L    + V  L  +PDG L L     D ++R++  L  +GN+     G
Sbjct: 49  IWDLRKGEKILILQGLKQEVTCLCPSPDG-LHLAVGYEDGSIRIFSLLSGEGNV--TFNG 105

Query: 213 HQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLA 272
           H+  + +  +      L S      + +W++   + + +L+GH   +    F  +  LL 
Sbjct: 106 HKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLV 165

Query: 273 TASYDTRVYIWD 284
           T+  DT V  WD
Sbjct: 166 TSGKDTMVKWWD 177



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 25/101 (24%), Positives = 48/101 (47%), Gaps = 2/101 (1%)

Query: 143 LATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKD 202
           LA+G  +  I +WDV     L  L  H + +    F  + +L LV++ +D  ++ WDL D
Sbjct: 122 LASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNL-LVTSGKDTMVKWWDL-D 179

Query: 203 DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNM 243
             +  K + GH+  V+      +   L +  +   + +W++
Sbjct: 180 TQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220



 Score = 35.4 bits (80), Expect = 0.098
 Identities = 33/148 (22%), Positives = 57/148 (38%), Gaps = 14/148 (9%)

Query: 197 VWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHH 256
           +WDL+  G  + +L+G +  V     SPD   L       ++ ++++          GH 
Sbjct: 49  IWDLRK-GEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHK 107

Query: 257 HDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRS 316
             +    +   G  LA+ S DT + +WD  N   L                G  D   ++
Sbjct: 108 AAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRL------------KGHKDAITQA 155

Query: 317 VSFSHDGLHVASLADDKMVRFWRIDEDY 344
           +      L V S   D MV++W +D  +
Sbjct: 156 LFLREKNLLVTS-GKDTMVKWWDLDTQH 182



 Score = 33.5 bits (75), Expect = 0.37
 Identities = 20/65 (30%), Positives = 31/65 (47%), Gaps = 1/65 (1%)

Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
           F +++ LL T   +  +K WD+ T      +V H   V  L    +   ++  AS D  L
Sbjct: 157 FLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGAS-DSEL 215

Query: 196 RVWDL 200
           RVWD+
Sbjct: 216 RVWDI 220



 Score = 31.6 bits (70), Expect = 1.4
 Identities = 22/67 (32%), Positives = 34/67 (50%), Gaps = 1/67 (1%)

Query: 231 SVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDI 290
           +V A + VF+W++ K   I  L+G   +V     SPDG  LA    D  + I+   +G+ 
Sbjct: 40  AVPACEHVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEG 99

Query: 291 LMEF-GH 296
            + F GH
Sbjct: 100 NVTFNGH 106


>gi|48928050 F-box and WD repeat domain containing 11 isoform C
           [Homo sapiens]
          Length = 542

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 65/270 (24%), Positives = 114/270 (42%), Gaps = 35/270 (12%)

Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198
           D+ ++ TG ++  +++WDV TG++L  L+ H E V  L F+   + ++V+ S+D+++ VW
Sbjct: 289 DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS---NGLMVTCSKDRSIAVW 345

Query: 199 DLKD--DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHH 256
           D+    D  + +VL GH+  V    F  D   + S    + + +W+      +R L GH 
Sbjct: 346 DMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHK 403

Query: 257 HDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVR 315
             +    +     L+ + S D  + +WD   G  L    GH              +  VR
Sbjct: 404 RGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGH--------------EELVR 447

Query: 316 SVSFSHDGLHVASLADDKMVRFW----RIDEDYPVQVAPL-----SNGLCCAFSTDGSVL 366
            + F  D   + S A D  ++ W     +D   P     L      +G       D   +
Sbjct: 448 CIRF--DNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQI 505

Query: 367 AAGTHDGSVYFWATPRQVPSLQHLCRMSIR 396
            + +HD ++  W      PS Q+  R   R
Sbjct: 506 ISSSHDDTILIWDFLNVPPSAQNETRSPSR 535



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 65/243 (26%), Positives = 100/243 (41%), Gaps = 26/243 (10%)

Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198
           D   + +GL +  IKIWD  + + L  L  HT  V  L +      ++V+ S D T+RVW
Sbjct: 249 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY---DERVIVTGSSDSTVRVW 305

Query: 199 DLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMI---RKLEGH 255
           D+ + G ++  L  H   V    FS    + CS   S AV  W+M   T I   R L GH
Sbjct: 306 DV-NTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAV--WDMASATDITLRRVLVGH 362

Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVR 315
              V   DF  D   + +AS D  + +W     + +                  + R + 
Sbjct: 363 RAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTL-------------NGHKRGIA 407

Query: 316 SVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSV 375
            + +  D L V S + D  +R W I+    ++V      L      D   + +G +DG +
Sbjct: 408 CLQY-RDRL-VVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKI 465

Query: 376 YFW 378
             W
Sbjct: 466 KVW 468



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 43/164 (26%), Positives = 64/164 (39%), Gaps = 26/164 (15%)

Query: 45  DGSYFAWSQGHRTVKLVPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKPREHII 104
           D  Y   + G RT+K+   S C     L+G K        R  R    G   N  R   I
Sbjct: 372 DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR-DRLVVSGSSDNTIRLWDI 430

Query: 105 DCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTG---- 160
           +CG  +  L       E+  RC+           D   + +G  +G+IK+WD+       
Sbjct: 431 ECGACLRVL----EGHEELVRCIRF---------DNKRIVSGAYDGKIKVWDLQAALDPR 477

Query: 161 -----KLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWD 199
                  L  LV+H+  V  L F       ++S+S D T+ +WD
Sbjct: 478 APASTLCLRTLVEHSGRVFRLQF---DEFQIISSSHDDTILIWD 518


>gi|148536855 coatomer protein complex, subunit alpha isoform 1
           [Homo sapiens]
          Length = 1233

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 66/259 (25%), Positives = 111/259 (42%), Gaps = 29/259 (11%)

Query: 143 LATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKD 202
           + T L+NG I++WD     L+    +H   VR + F     L  VS   D  ++VW+ K 
Sbjct: 24  ILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLF-VSGGDDYKIKVWNYKL 82

Query: 203 DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVAC 262
              +  +L GH +++ +  F  +   + S    + + +WN    T +  L GH+H V+  
Sbjct: 83  RRCLFTLL-GHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCA 141

Query: 263 DFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPP--------TPIFAGGANDRWV 314
            F P   L+ +AS D  V +WD       +   +L P          T +   G  D  V
Sbjct: 142 QFHPTEDLVVSASLDQTVRVWDISG----LRKKNLSPGAVESDVRGITGVDLFGTTDAVV 197

Query: 315 RSVSFSHD-GLH----------VASLADDKMVRFWRIDEDYPVQV----APLSNGLCCAF 359
           + V   HD G++          + S ADD+ V+ WR++E    +V       +N  C  F
Sbjct: 198 KHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVF 257

Query: 360 STDGSVLAAGTHDGSVYFW 378
                ++ + + D S+  W
Sbjct: 258 HPRQELILSNSEDKSIRVW 276



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 42/162 (25%), Positives = 65/162 (40%), Gaps = 30/162 (18%)

Query: 152 IKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKD--------- 202
           I++W+  +   +  L  H   V    F P   L+ VSAS D+T+RVWD+           
Sbjct: 117 IRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLV-VSASLDQTVRVWDISGLRKKNLSPG 175

Query: 203 ------------------DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMD 244
                             D  +  VL GH   V   AF P   ++ S    + V +W M+
Sbjct: 176 AVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235

Query: 245 --KYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 284
             K   +    GH+++V    F P   L+ + S D  + +WD
Sbjct: 236 ESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWD 277



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 35/165 (21%), Positives = 62/165 (37%), Gaps = 17/165 (10%)

Query: 217 VYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASY 276
           V   +F P    + +   +  + LW+    T+I K + H   V   DF     L  +   
Sbjct: 12  VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGD 71

Query: 277 DTRVYIWDPHNGDILME-FGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMV 335
           D ++ +W+      L    GHL               ++R+  F H+   + S +DD+ +
Sbjct: 72  DYKIKVWNYKLRRCLFTLLGHL--------------DYIRTTFFHHEYPWILSASDDQTI 117

Query: 336 RFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW 378
           R W       V V    N   +C  F     ++ + + D +V  W
Sbjct: 118 RVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVW 162



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 25/92 (27%), Positives = 41/92 (44%), Gaps = 2/92 (2%)

Query: 166 LVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNM-MKVLRGHQNWVYSCAFSP 224
           L  H   V    F P   LI VS + D+ +++W + +     +   RGH N V    F P
Sbjct: 201 LEGHDRGVNWAAFHPTMPLI-VSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHP 259

Query: 225 DSSMLCSVGASKAVFLWNMDKYTMIRKLEGHH 256
              ++ S    K++ +W+M K T ++     H
Sbjct: 260 RQELILSNSEDKSIRVWDMSKRTGVQTFRRDH 291



 Score = 35.4 bits (80), Expect = 0.098
 Identities = 53/198 (26%), Positives = 79/198 (39%), Gaps = 26/198 (13%)

Query: 38  WTVAFAPDGSYFAWSQGHRTVKLV-----PWSQCLQNFLLHGTKNVTNSSSL-RLPRQNS 91
           W ++ + D +   W+   RT   V      +  C Q    H T+++  S+SL +  R   
Sbjct: 107 WILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQ---FHPTEDLVVSASLDQTVRVWD 163

Query: 92  DGGQKNK---PREHIIDCGDIVWSLAFGSS------VPEKQSRCVNIEWHRFRFGQDQLL 142
             G + K   P     D   I     FG++      V E   R VN  W  F       L
Sbjct: 164 ISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVN--WAAFH--PTMPL 219

Query: 143 LATGLNNGRIKIWDVYTGKL--LLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDL 200
           + +G ++ ++KIW +   K   +     H   V    F P   LIL S S DK++RVWD+
Sbjct: 220 IVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELIL-SNSEDKSIRVWDM 278

Query: 201 KDDGNMMKVLRGHQN-WV 217
                +    R H   WV
Sbjct: 279 SKRTGVQTFRRDHDRFWV 296


>gi|148536853 coatomer protein complex, subunit alpha isoform 2
           [Homo sapiens]
          Length = 1224

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 66/259 (25%), Positives = 111/259 (42%), Gaps = 29/259 (11%)

Query: 143 LATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKD 202
           + T L+NG I++WD     L+    +H   VR + F     L  VS   D  ++VW+ K 
Sbjct: 24  ILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLF-VSGGDDYKIKVWNYKL 82

Query: 203 DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVAC 262
              +  +L GH +++ +  F  +   + S    + + +WN    T +  L GH+H V+  
Sbjct: 83  RRCLFTLL-GHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCA 141

Query: 263 DFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPP--------TPIFAGGANDRWV 314
            F P   L+ +AS D  V +WD       +   +L P          T +   G  D  V
Sbjct: 142 QFHPTEDLVVSASLDQTVRVWDISG----LRKKNLSPGAVESDVRGITGVDLFGTTDAVV 197

Query: 315 RSVSFSHD-GLH----------VASLADDKMVRFWRIDEDYPVQV----APLSNGLCCAF 359
           + V   HD G++          + S ADD+ V+ WR++E    +V       +N  C  F
Sbjct: 198 KHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVF 257

Query: 360 STDGSVLAAGTHDGSVYFW 378
                ++ + + D S+  W
Sbjct: 258 HPRQELILSNSEDKSIRVW 276



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 42/162 (25%), Positives = 65/162 (40%), Gaps = 30/162 (18%)

Query: 152 IKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKD--------- 202
           I++W+  +   +  L  H   V    F P   L+ VSAS D+T+RVWD+           
Sbjct: 117 IRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLV-VSASLDQTVRVWDISGLRKKNLSPG 175

Query: 203 ------------------DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMD 244
                             D  +  VL GH   V   AF P   ++ S    + V +W M+
Sbjct: 176 AVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235

Query: 245 --KYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 284
             K   +    GH+++V    F P   L+ + S D  + +WD
Sbjct: 236 ESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWD 277



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 35/165 (21%), Positives = 62/165 (37%), Gaps = 17/165 (10%)

Query: 217 VYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASY 276
           V   +F P    + +   +  + LW+    T+I K + H   V   DF     L  +   
Sbjct: 12  VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGD 71

Query: 277 DTRVYIWDPHNGDILME-FGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMV 335
           D ++ +W+      L    GHL               ++R+  F H+   + S +DD+ +
Sbjct: 72  DYKIKVWNYKLRRCLFTLLGHL--------------DYIRTTFFHHEYPWILSASDDQTI 117

Query: 336 RFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW 378
           R W       V V    N   +C  F     ++ + + D +V  W
Sbjct: 118 RVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVW 162



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 25/92 (27%), Positives = 41/92 (44%), Gaps = 2/92 (2%)

Query: 166 LVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNM-MKVLRGHQNWVYSCAFSP 224
           L  H   V    F P   LI VS + D+ +++W + +     +   RGH N V    F P
Sbjct: 201 LEGHDRGVNWAAFHPTMPLI-VSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHP 259

Query: 225 DSSMLCSVGASKAVFLWNMDKYTMIRKLEGHH 256
              ++ S    K++ +W+M K T ++     H
Sbjct: 260 RQELILSNSEDKSIRVWDMSKRTGVQTFRRDH 291



 Score = 35.4 bits (80), Expect = 0.098
 Identities = 53/198 (26%), Positives = 79/198 (39%), Gaps = 26/198 (13%)

Query: 38  WTVAFAPDGSYFAWSQGHRTVKLV-----PWSQCLQNFLLHGTKNVTNSSSL-RLPRQNS 91
           W ++ + D +   W+   RT   V      +  C Q    H T+++  S+SL +  R   
Sbjct: 107 WILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQ---FHPTEDLVVSASLDQTVRVWD 163

Query: 92  DGGQKNK---PREHIIDCGDIVWSLAFGSS------VPEKQSRCVNIEWHRFRFGQDQLL 142
             G + K   P     D   I     FG++      V E   R VN  W  F       L
Sbjct: 164 ISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVN--WAAFH--PTMPL 219

Query: 143 LATGLNNGRIKIWDVYTGKL--LLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDL 200
           + +G ++ ++KIW +   K   +     H   V    F P   LIL S S DK++RVWD+
Sbjct: 220 IVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELIL-SNSEDKSIRVWDM 278

Query: 201 KDDGNMMKVLRGHQN-WV 217
                +    R H   WV
Sbjct: 279 SKRTGVQTFRRDHDRFWV 296


>gi|48928048 F-box and WD repeat domain containing 11 isoform A
           [Homo sapiens]
          Length = 508

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 65/270 (24%), Positives = 114/270 (42%), Gaps = 35/270 (12%)

Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198
           D+ ++ TG ++  +++WDV TG++L  L+ H E V  L F+   + ++V+ S+D+++ VW
Sbjct: 255 DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS---NGLMVTCSKDRSIAVW 311

Query: 199 DLKD--DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHH 256
           D+    D  + +VL GH+  V    F  D   + S    + + +W+      +R L GH 
Sbjct: 312 DMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHK 369

Query: 257 HDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVR 315
             +    +     L+ + S D  + +WD   G  L    GH              +  VR
Sbjct: 370 RGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGH--------------EELVR 413

Query: 316 SVSFSHDGLHVASLADDKMVRFW----RIDEDYPVQVAPL-----SNGLCCAFSTDGSVL 366
            + F  D   + S A D  ++ W     +D   P     L      +G       D   +
Sbjct: 414 CIRF--DNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQI 471

Query: 367 AAGTHDGSVYFWATPRQVPSLQHLCRMSIR 396
            + +HD ++  W      PS Q+  R   R
Sbjct: 472 ISSSHDDTILIWDFLNVPPSAQNETRSPSR 501



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 65/243 (26%), Positives = 100/243 (41%), Gaps = 26/243 (10%)

Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198
           D   + +GL +  IKIWD  + + L  L  HT  V  L +      ++V+ S D T+RVW
Sbjct: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY---DERVIVTGSSDSTVRVW 271

Query: 199 DLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMI---RKLEGH 255
           D+ + G ++  L  H   V    FS    + CS   S AV  W+M   T I   R L GH
Sbjct: 272 DV-NTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAV--WDMASATDITLRRVLVGH 328

Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVR 315
              V   DF  D   + +AS D  + +W     + +                  + R + 
Sbjct: 329 RAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTL-------------NGHKRGIA 373

Query: 316 SVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSV 375
            + +  D L V S + D  +R W I+    ++V      L      D   + +G +DG +
Sbjct: 374 CLQY-RDRL-VVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKI 431

Query: 376 YFW 378
             W
Sbjct: 432 KVW 434



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 43/164 (26%), Positives = 64/164 (39%), Gaps = 26/164 (15%)

Query: 45  DGSYFAWSQGHRTVKLVPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKPREHII 104
           D  Y   + G RT+K+   S C     L+G K        R  R    G   N  R   I
Sbjct: 338 DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR-DRLVVSGSSDNTIRLWDI 396

Query: 105 DCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTG---- 160
           +CG  +  L       E+  RC+           D   + +G  +G+IK+WD+       
Sbjct: 397 ECGACLRVL----EGHEELVRCIRF---------DNKRIVSGAYDGKIKVWDLQAALDPR 443

Query: 161 -----KLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWD 199
                  L  LV+H+  V  L F       ++S+S D T+ +WD
Sbjct: 444 APASTLCLRTLVEHSGRVFRLQF---DEFQIISSSHDDTILIWD 484


>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
           sapiens]
          Length = 472

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 45/180 (25%), Positives = 81/180 (45%), Gaps = 20/180 (11%)

Query: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 228
           HT  +    F PD   +  S S D+ +++WD+     ++ + + H N + +C F+     
Sbjct: 229 HTRSITSCCFDPDSQRV-ASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHF 287

Query: 229 LCSVGASKAVFLWNM------DKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYI 282
           LC+    K + +WN+      +    +  ++GH   V +C F+ D + L +  +D  V I
Sbjct: 288 LCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAI 347

Query: 283 WDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDE 342
           WD   G               +   G ND WV  V+ S++   + S + D+ +R W I+E
Sbjct: 348 WDVAEG------------YRKLSLKGHND-WVMDVAISNNKKWILSASKDRTMRLWNIEE 394



 Score = 65.9 bits (159), Expect = 7e-11
 Identities = 41/139 (29%), Positives = 73/139 (52%), Gaps = 7/139 (5%)

Query: 152 IKIWDVYTGKLLLNLVD-HTEVVRDLTFAPDGSLILVSASRDKTLRVWDL-----KDDGN 205
           IKIWDV +   LL +   H+  + +  F   G  +  S S DK L++W++     ++ G 
Sbjct: 254 IKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTS-SWDKNLKIWNVHTGEFRNCGA 312

Query: 206 MMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFS 265
            + +++GH+  V SC F+ DSS L S G  + V +W++ +      L+GH+  V+    S
Sbjct: 313 CVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAIS 372

Query: 266 PDGALLATASYDTRVYIWD 284
            +   + +AS D  + +W+
Sbjct: 373 NNKKWILSASKDRTMRLWN 391



 Score = 55.8 bits (133), Expect = 7e-08
 Identities = 36/119 (30%), Positives = 54/119 (45%), Gaps = 13/119 (10%)

Query: 252 LEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGAND 311
           L GH H V  C F  D   L + SYD  V +WDP +G ++ +F H   P  P+       
Sbjct: 98  LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEH--RPKAPVV------ 149

Query: 312 RWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPV-QVAPLSNGLCCAFSTDGSVLAAG 369
                 S + D   V + + DK VR W ++    + +V   +  + C FS DG  + +G
Sbjct: 150 ----ECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSG 204



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 49/205 (23%), Positives = 78/205 (38%), Gaps = 34/205 (16%)

Query: 208 KVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH-HHDVVACDFSP 266
           K+L GH++ V +C F  D + L S      V LW+    +++R  E      VV C  + 
Sbjct: 96  KILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITG 155

Query: 267 DGALLATASYDTRVYIWDPHNGDILMEFGH-------LFPPPTPIFAGG----------- 308
           D + +  ASYD  V  WD   G +L +  +        F P       G           
Sbjct: 156 DSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMD 215

Query: 309 ---------ANDRWVRSVS---FSHDGLHVASLADDKMVRFWRIDEDYPVQVAPL--SNG 354
                      D   RS++   F  D   VAS++ D+ ++ W +     +       SN 
Sbjct: 216 AENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNA 275

Query: 355 LC-CAFSTDGSVLAAGTHDGSVYFW 378
           +  C F+  G  L   + D ++  W
Sbjct: 276 ISNCCFTFSGHFLCTSSWDKNLKIW 300



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 24/76 (31%), Positives = 44/76 (57%), Gaps = 1/76 (1%)

Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
           F +D   L +G  +  + IWDV  G   L+L  H + V D+  + +   IL SAS+D+T+
Sbjct: 329 FARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWIL-SASKDRTM 387

Query: 196 RVWDLKDDGNMMKVLR 211
           R+W++++   +  V++
Sbjct: 388 RLWNIEEIDEIPLVIK 403


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.444 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,993,736
Number of Sequences: 37866
Number of extensions: 810764
Number of successful extensions: 4499
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 240
Number of HSP's successfully gapped in prelim test: 111
Number of HSP's that attempted gapping in prelim test: 1616
Number of HSP's gapped (non-prelim): 1540
length of query: 421
length of database: 18,247,518
effective HSP length: 105
effective length of query: 316
effective length of database: 14,271,588
effective search space: 4509821808
effective search space used: 4509821808
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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