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Search of human proteins with 166295194
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|166295194 checkpoint kinase 1 [Homo sapiens]
(476 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|166295196 checkpoint kinase 1 [Homo sapiens] 978 0.0
gi|166295194 checkpoint kinase 1 [Homo sapiens] 978 0.0
gi|166295192 checkpoint kinase 1 [Homo sapiens] 978 0.0
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 174 2e-43
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 174 2e-43
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 174 2e-43
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 174 2e-43
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 174 2e-43
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 167 2e-41
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 167 2e-41
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 167 2e-41
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 167 2e-41
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 167 2e-41
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 166 4e-41
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 164 2e-40
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 163 4e-40
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 160 2e-39
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 160 2e-39
gi|116256471 SNF1-like kinase [Homo sapiens] 159 5e-39
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 157 2e-38
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 155 1e-37
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 154 2e-37
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa... 151 1e-36
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub... 150 3e-36
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 148 9e-36
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 144 1e-34
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 144 1e-34
gi|149589021 doublecortin-like kinase 3 [Homo sapiens] 142 7e-34
gi|54112407 protein kinase CHK2 isoform c [Homo sapiens] 140 3e-33
gi|6005850 protein kinase CHK2 isoform a [Homo sapiens] 140 3e-33
>gi|166295196 checkpoint kinase 1 [Homo sapiens]
Length = 476
Score = 978 bits (2529), Expect = 0.0
Identities = 476/476 (100%), Positives = 476/476 (100%)
Query: 1 MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK 60
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
Sbjct: 1 MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK 60
Query: 61 MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY 120
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
Sbjct: 61 MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY 120
Query: 121 LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK 180
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
Sbjct: 121 LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK 180
Query: 181 RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA 240
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
Sbjct: 181 RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA 240
Query: 241 LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF 300
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
Sbjct: 241 LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF 300
Query: 301 SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL 360
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
Sbjct: 301 SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL 360
Query: 361 GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR 420
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
Sbjct: 361 GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR 420
Query: 421 NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT 476
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
Sbjct: 421 NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT 476
>gi|166295194 checkpoint kinase 1 [Homo sapiens]
Length = 476
Score = 978 bits (2529), Expect = 0.0
Identities = 476/476 (100%), Positives = 476/476 (100%)
Query: 1 MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK 60
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
Sbjct: 1 MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK 60
Query: 61 MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY 120
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
Sbjct: 61 MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY 120
Query: 121 LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK 180
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
Sbjct: 121 LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK 180
Query: 181 RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA 240
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
Sbjct: 181 RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA 240
Query: 241 LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF 300
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
Sbjct: 241 LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF 300
Query: 301 SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL 360
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
Sbjct: 301 SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL 360
Query: 361 GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR 420
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
Sbjct: 361 GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR 420
Query: 421 NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT 476
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
Sbjct: 421 NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT 476
>gi|166295192 checkpoint kinase 1 [Homo sapiens]
Length = 476
Score = 978 bits (2529), Expect = 0.0
Identities = 476/476 (100%), Positives = 476/476 (100%)
Query: 1 MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK 60
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
Sbjct: 1 MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK 60
Query: 61 MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY 120
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
Sbjct: 61 MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY 120
Query: 121 LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK 180
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
Sbjct: 121 LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK 180
Query: 181 RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA 240
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
Sbjct: 181 RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA 240
Query: 241 LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF 300
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
Sbjct: 241 LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF 300
Query: 301 SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL 360
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
Sbjct: 301 SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL 360
Query: 361 GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR 420
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
Sbjct: 361 GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR 420
Query: 421 NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT 476
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
Sbjct: 421 NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT 476
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 174 bits (440), Expect = 2e-43
Identities = 99/264 (37%), Positives = 154/264 (58%), Gaps = 7/264 (2%)
Query: 4 PFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCP-ENIKKEICINKML 62
P + ++ L++T+G+G + +V+LA + +T + VAVKI+D + + + +E+ I K+L
Sbjct: 48 PHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVL 107
Query: 63 NHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLH 122
NH N+VK + YL +EY SGGE+FD + M E +A+ F Q+++ V Y H
Sbjct: 108 NHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 167
Query: 123 GIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRR 182
I HRD+K ENLLLD N+KI+DFG + F + N+ L+ CG+ PY APEL + +
Sbjct: 168 QKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK---LDTFCGSPPYAAPELFQGK 224
Query: 183 EFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALL 242
++ VDVWS G++L +++G LP+D + +E + + Y P+ LL
Sbjct: 225 KYDGPEVDVWSLGVILYTLVSGSLPFD--GQNLKELRERVLRGKYRIPFYMSTDCE-NLL 281
Query: 243 HKILVENPSARITIPDIKKDRWYN 266
K L+ NPS R T+ I KDRW N
Sbjct: 282 KKFLILNPSKRGTLEQIMKDRWMN 305
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 174 bits (440), Expect = 2e-43
Identities = 99/264 (37%), Positives = 154/264 (58%), Gaps = 7/264 (2%)
Query: 4 PFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCP-ENIKKEICINKML 62
P + ++ L++T+G+G + +V+LA + +T + VAVKI+D + + + +E+ I K+L
Sbjct: 48 PHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVL 107
Query: 63 NHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLH 122
NH N+VK + YL +EY SGGE+FD + M E +A+ F Q+++ V Y H
Sbjct: 108 NHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 167
Query: 123 GIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRR 182
I HRD+K ENLLLD N+KI+DFG + F + N+ L+ CG+ PY APEL + +
Sbjct: 168 QKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK---LDTFCGSPPYAAPELFQGK 224
Query: 183 EFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALL 242
++ VDVWS G++L +++G LP+D + +E + + Y P+ LL
Sbjct: 225 KYDGPEVDVWSLGVILYTLVSGSLPFD--GQNLKELRERVLRGKYRIPFYMSTDCE-NLL 281
Query: 243 HKILVENPSARITIPDIKKDRWYN 266
K L+ NPS R T+ I KDRW N
Sbjct: 282 KKFLILNPSKRGTLEQIMKDRWMN 305
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 174 bits (440), Expect = 2e-43
Identities = 99/264 (37%), Positives = 154/264 (58%), Gaps = 7/264 (2%)
Query: 4 PFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCP-ENIKKEICINKML 62
P + ++ L++T+G+G + +V+LA + +T + VAVKI+D + + + +E+ I K+L
Sbjct: 48 PHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVL 107
Query: 63 NHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLH 122
NH N+VK + YL +EY SGGE+FD + M E +A+ F Q+++ V Y H
Sbjct: 108 NHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 167
Query: 123 GIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRR 182
I HRD+K ENLLLD N+KI+DFG + F + N+ L+ CG+ PY APEL + +
Sbjct: 168 QKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK---LDTFCGSPPYAAPELFQGK 224
Query: 183 EFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALL 242
++ VDVWS G++L +++G LP+D + +E + + Y P+ LL
Sbjct: 225 KYDGPEVDVWSLGVILYTLVSGSLPFD--GQNLKELRERVLRGKYRIPFYMSTDCE-NLL 281
Query: 243 HKILVENPSARITIPDIKKDRWYN 266
K L+ NPS R T+ I KDRW N
Sbjct: 282 KKFLILNPSKRGTLEQIMKDRWMN 305
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 174 bits (440), Expect = 2e-43
Identities = 99/264 (37%), Positives = 154/264 (58%), Gaps = 7/264 (2%)
Query: 4 PFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCP-ENIKKEICINKML 62
P + ++ L++T+G+G + +V+LA + +T + VAVKI+D + + + +E+ I K+L
Sbjct: 48 PHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVL 107
Query: 63 NHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLH 122
NH N+VK + YL +EY SGGE+FD + M E +A+ F Q+++ V Y H
Sbjct: 108 NHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 167
Query: 123 GIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRR 182
I HRD+K ENLLLD N+KI+DFG + F + N+ L+ CG+ PY APEL + +
Sbjct: 168 QKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK---LDTFCGSPPYAAPELFQGK 224
Query: 183 EFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALL 242
++ VDVWS G++L +++G LP+D + +E + + Y P+ LL
Sbjct: 225 KYDGPEVDVWSLGVILYTLVSGSLPFD--GQNLKELRERVLRGKYRIPFYMSTDCE-NLL 281
Query: 243 HKILVENPSARITIPDIKKDRWYN 266
K L+ NPS R T+ I KDRW N
Sbjct: 282 KKFLILNPSKRGTLEQIMKDRWMN 305
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 174 bits (440), Expect = 2e-43
Identities = 99/264 (37%), Positives = 154/264 (58%), Gaps = 7/264 (2%)
Query: 4 PFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCP-ENIKKEICINKML 62
P + ++ L++T+G+G + +V+LA + +T + VAVKI+D + + + +E+ I K+L
Sbjct: 15 PHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVL 74
Query: 63 NHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLH 122
NH N+VK + YL +EY SGGE+FD + M E +A+ F Q+++ V Y H
Sbjct: 75 NHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 134
Query: 123 GIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRR 182
I HRD+K ENLLLD N+KI+DFG + F + N+ L+ CG+ PY APEL + +
Sbjct: 135 QKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK---LDTFCGSPPYAAPELFQGK 191
Query: 183 EFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALL 242
++ VDVWS G++L +++G LP+D + +E + + Y P+ LL
Sbjct: 192 KYDGPEVDVWSLGVILYTLVSGSLPFD--GQNLKELRERVLRGKYRIPFYMSTDCE-NLL 248
Query: 243 HKILVENPSARITIPDIKKDRWYN 266
K L+ NPS R T+ I KDRW N
Sbjct: 249 KKFLILNPSKRGTLEQIMKDRWMN 272
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 167 bits (423), Expect = 2e-41
Identities = 98/264 (37%), Positives = 151/264 (57%), Gaps = 7/264 (2%)
Query: 4 PFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCP-ENIKKEICINKML 62
P + ++ L +T+G+G + +V+LA + +T VAVKI+D + + + +E+ I K+L
Sbjct: 55 PHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKIL 114
Query: 63 NHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLH 122
NH N+VK + YL +EY SGGE+FD + M E +A+ F Q+++ V Y H
Sbjct: 115 NHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 174
Query: 123 GIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRR 182
I HRD+K ENLLLD N+KI+DFG + F N+ L+ CG+ PY APEL + +
Sbjct: 175 QKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNK---LDTFCGSPPYAAPELFQGK 231
Query: 183 EFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALL 242
++ VDVWS G++L +++G LP+D + +E + + Y P+ LL
Sbjct: 232 KYDGPEVDVWSLGVILYTLVSGSLPFD--GQNLKELRERVLRGKYRIPFYMSTDCE-NLL 288
Query: 243 HKILVENPSARITIPDIKKDRWYN 266
K+LV NP R ++ I KDRW N
Sbjct: 289 KKLLVLNPIKRGSLEQIMKDRWMN 312
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 167 bits (423), Expect = 2e-41
Identities = 98/276 (35%), Positives = 155/276 (56%), Gaps = 7/276 (2%)
Query: 4 PFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCP-ENIKKEICINKML 62
P + ++ L++T+G+G + +V+LA + +T VA+KI+D + + + +E+ I K+L
Sbjct: 51 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKIL 110
Query: 63 NHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLH 122
NH N+VK + YL +EY SGGE+FD + M E +A+ F Q+++ V Y H
Sbjct: 111 NHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCH 170
Query: 123 GIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRR 182
I HRD+K ENLLLD N+KI+DFG + F + L+ CG+ PY APEL + +
Sbjct: 171 QKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGK---LDTFCGSPPYAAPELFQGK 227
Query: 183 EFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALL 242
++ VDVWS G++L +++G LP+D + +E + + Y P+ LL
Sbjct: 228 KYDGPEVDVWSLGVILYTLVSGSLPFD--GQNLKELRERVLRGKYRIPFYMSTDCE-NLL 284
Query: 243 HKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRV 278
+ LV NP R T+ I KDRW N ++ +P V
Sbjct: 285 KRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFV 320
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 167 bits (423), Expect = 2e-41
Identities = 98/276 (35%), Positives = 155/276 (56%), Gaps = 7/276 (2%)
Query: 4 PFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCP-ENIKKEICINKML 62
P + ++ L++T+G+G + +V+LA + +T VA+KI+D + + + +E+ I K+L
Sbjct: 51 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKIL 110
Query: 63 NHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLH 122
NH N+VK + YL +EY SGGE+FD + M E +A+ F Q+++ V Y H
Sbjct: 111 NHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCH 170
Query: 123 GIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRR 182
I HRD+K ENLLLD N+KI+DFG + F + L+ CG+ PY APEL + +
Sbjct: 171 QKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGK---LDTFCGSPPYAAPELFQGK 227
Query: 183 EFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALL 242
++ VDVWS G++L +++G LP+D + +E + + Y P+ LL
Sbjct: 228 KYDGPEVDVWSLGVILYTLVSGSLPFD--GQNLKELRERVLRGKYRIPFYMSTDCE-NLL 284
Query: 243 HKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRV 278
+ LV NP R T+ I KDRW N ++ +P V
Sbjct: 285 KRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFV 320
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 167 bits (423), Expect = 2e-41
Identities = 98/276 (35%), Positives = 155/276 (56%), Gaps = 7/276 (2%)
Query: 4 PFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCP-ENIKKEICINKML 62
P + ++ L++T+G+G + +V+LA + +T VA+KI+D + + + +E+ I K+L
Sbjct: 51 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKIL 110
Query: 63 NHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLH 122
NH N+VK + YL +EY SGGE+FD + M E +A+ F Q+++ V Y H
Sbjct: 111 NHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCH 170
Query: 123 GIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRR 182
I HRD+K ENLLLD N+KI+DFG + F + L+ CG+ PY APEL + +
Sbjct: 171 QKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGK---LDTFCGSPPYAAPELFQGK 227
Query: 183 EFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALL 242
++ VDVWS G++L +++G LP+D + +E + + Y P+ LL
Sbjct: 228 KYDGPEVDVWSLGVILYTLVSGSLPFD--GQNLKELRERVLRGKYRIPFYMSTDCE-NLL 284
Query: 243 HKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRV 278
+ LV NP R T+ I KDRW N ++ +P V
Sbjct: 285 KRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFV 320
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 167 bits (423), Expect = 2e-41
Identities = 98/276 (35%), Positives = 155/276 (56%), Gaps = 7/276 (2%)
Query: 4 PFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCP-ENIKKEICINKML 62
P + ++ L++T+G+G + +V+LA + +T VA+KI+D + + + +E+ I K+L
Sbjct: 51 PHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKIL 110
Query: 63 NHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLH 122
NH N+VK + YL +EY SGGE+FD + M E +A+ F Q+++ V Y H
Sbjct: 111 NHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCH 170
Query: 123 GIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRR 182
I HRD+K ENLLLD N+KI+DFG + F + L+ CG+ PY APEL + +
Sbjct: 171 QKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGK---LDTFCGSPPYAAPELFQGK 227
Query: 183 EFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALL 242
++ VDVWS G++L +++G LP+D + +E + + Y P+ LL
Sbjct: 228 KYDGPEVDVWSLGVILYTLVSGSLPFD--GQNLKELRERVLRGKYRIPFYMSTDCE-NLL 284
Query: 243 HKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRV 278
+ LV NP R T+ I KDRW N ++ +P V
Sbjct: 285 KRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFV 320
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 166 bits (420), Expect = 4e-41
Identities = 95/266 (35%), Positives = 153/266 (57%), Gaps = 11/266 (4%)
Query: 4 PFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKK---EICINK 60
P V ++ L++T+G+G + +V+LA + +T VA+KI+D + P +++K E+ I K
Sbjct: 54 PHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN--PSSLQKLFREVRIMK 111
Query: 61 MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY 120
LNH N+VK + YL +EY S GE+FD + M E +A+ F Q+++ V Y
Sbjct: 112 GLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHY 171
Query: 121 LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK 180
H I HRD+K ENLLLD N+KI+DFG + F ++ L+ CG+ PY APEL +
Sbjct: 172 CHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSK---LDTFCGSPPYAAPELFQ 228
Query: 181 RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA 240
+++ VD+WS G++L +++G LP+D + +E + + Y P+ +
Sbjct: 229 GKKYDGPEVDIWSLGVILYTLVSGSLPFD--GHNLKELRERVLRGKYRVPFYMSTDCE-S 285
Query: 241 LLHKILVENPSARITIPDIKKDRWYN 266
+L + LV NP+ R T+ I KD+W N
Sbjct: 286 ILRRFLVLNPAKRCTLEQIMKDKWIN 311
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 164 bits (415), Expect = 2e-40
Identities = 111/378 (29%), Positives = 195/378 (51%), Gaps = 22/378 (5%)
Query: 9 WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKR--AVDCPENIKKEICINKMLNHEN 66
+D+ TLG+G + V+L +R+T+ VA+KI+D + AV+ E I +E+ I KML+H +
Sbjct: 20 YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNL-EKIYREVQIMKMLDHPH 78
Query: 67 VVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGI 126
++K Y ++ YL EY GE+FD + + E +A+R F Q+++ V Y HG I
Sbjct: 79 IIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKI 138
Query: 127 THRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHA 186
HRD+K ENLLLD N+KI+DFG F+ LL CG+ PY APE+ + +++
Sbjct: 139 VHRDLKAENLLLDNNMNIKIADFGFGNFFKSG---ELLATWCGSPPYAAPEVFEGQQYEG 195
Query: 187 EPVDVWSCGIVLTAMLAGELPWDQPSDSC--QEYSDWKEKKTYLNPWKKIDSAPLALLHK 244
+D+WS G+VL ++ G LP+D P+ Q + + + Y + L+ +
Sbjct: 196 PQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYF-----MSEDCEHLIRR 250
Query: 245 ILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPS--GFSKHIQSNLDFSP 302
+LV +PS R+TI IK+ +W ++ +RP + PS F++ + +
Sbjct: 251 MLVLDPSKRLTIAQIKEHKW--MLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLG 308
Query: 303 VNSASSEENVKYSSSQPEPRTGLSLWDTSPSY-----IDKLVQGISFSQPTCPDHMLLNS 357
++ + E+++ S L + S+ +++ + G T + + +
Sbjct: 309 IDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKA 368
Query: 358 QLLGTPGSSQNPWQRLVK 375
Q +G P + +P RL++
Sbjct: 369 QTVGLPVTMHSPNMRLLR 386
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 163 bits (412), Expect = 4e-40
Identities = 90/262 (34%), Positives = 155/262 (59%), Gaps = 7/262 (2%)
Query: 5 FVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCP-ENIKKEICINKMLN 63
+V + L +TLG+G G V+L V+ +T + VA+KIV+ ++ + +++EI I K++
Sbjct: 30 YVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIE 89
Query: 64 HENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG 123
H +V+K + YL LE+ SGGELFD + + +A++FF Q+++ + + H
Sbjct: 90 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHS 149
Query: 124 IGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRRE 183
I HRD+KPENLLLDE++N++I+DFG+A++ + LL CG+ Y PE++K +
Sbjct: 150 YSICHRDLKPENLLLDEKNNIRIADFGMASL---QVGDSLLETSCGSPHYACPEVIKGEK 206
Query: 184 FHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLH 243
+ D+WSCG++L A+L G LP+D D+ ++ + K K+ + I +LL
Sbjct: 207 YDGRRADMWSCGVILFALLVGALPFD--DDNLRQLLE-KVKRGVFHMPHFIPPDCQSLLR 263
Query: 244 KILVENPSARITIPDIKKDRWY 265
++ P R+++ I+K WY
Sbjct: 264 GMIEVEPEKRLSLEQIQKHPWY 285
>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
Length = 668
Score = 160 bits (406), Expect = 2e-39
Identities = 91/262 (34%), Positives = 156/262 (59%), Gaps = 7/262 (2%)
Query: 5 FVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCP-ENIKKEICINKMLN 63
+V + L +TLG+G G V+L V+ VT + VA+KIV+ ++ + +++EI I K++
Sbjct: 15 YVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIE 74
Query: 64 HENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG 123
H +V+K + YL LE+ SGGELFD + + +A++FF Q+++ + + H
Sbjct: 75 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHS 134
Query: 124 IGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRRE 183
I HRD+KPENLLLDE++N++I+DFG+A++ + LL CG+ Y PE+++ +
Sbjct: 135 HSICHRDLKPENLLLDEKNNIRIADFGMASL---QVGDSLLETSCGSPHYACPEVIRGEK 191
Query: 184 FHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLH 243
+ DVWSCG++L A+L G LP+D D+ ++ + K K+ + I +LL
Sbjct: 192 YDGRKADVWSCGVILFALLVGALPFD--DDNLRQLLE-KVKRGVFHMPHFIPPDCQSLLR 248
Query: 244 KILVENPSARITIPDIKKDRWY 265
++ + + R+T+ I+K WY
Sbjct: 249 GMIEVDAARRLTLEHIQKHIWY 270
>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
Length = 651
Score = 160 bits (406), Expect = 2e-39
Identities = 94/272 (34%), Positives = 147/272 (54%), Gaps = 8/272 (2%)
Query: 9 WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVV 68
++L +T+G G + +V+LA + +T E VA+KI+D IK EI K L H+++
Sbjct: 11 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHIC 70
Query: 69 KFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITH 128
+ Y N ++ LEYC GGELFD I + E + + F Q+++ V Y+H G H
Sbjct: 71 QLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAH 130
Query: 129 RDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEP 188
RD+KPENLL DE LK+ DFGL + N++ L CG+L Y APEL++ + +
Sbjct: 131 RDLKPENLLFDEYHKLKLIDFGLCAKPK-GNKDYHLQTCCGSLAYAAPELIQGKSYLGSE 189
Query: 189 VDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVE 248
DVWS GI+L ++ G LP+D + Y K + W + + + LL ++L
Sbjct: 190 ADVWSMGILLYVLMCGFLPFDD-DNVMALYKKIMRGKYDVPKW--LSPSSILLLQQMLQV 246
Query: 249 NPSARITIPDIKKDRW----YNKPLKKGAKRP 276
+P RI++ ++ W YN P++ +K P
Sbjct: 247 DPKKRISMKNLLNHPWIMQDYNYPVEWQSKNP 278
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 159 bits (402), Expect = 5e-39
Identities = 93/312 (29%), Positives = 170/312 (54%), Gaps = 12/312 (3%)
Query: 9 WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCP-ENIKKEICINKMLNHENV 67
+D+ +TLG+G + V+LA +RVT+ VA+KI+D R E I +E+ + K+LNH ++
Sbjct: 27 YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHI 86
Query: 68 VKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGIT 127
+K Y ++ Y+ E+ GE+FD + + + E +A++ F Q+++ V Y H I
Sbjct: 87 IKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIV 146
Query: 128 HRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAE 187
HRD+K ENLLLD ++K++DFG ++ L+ CG+ PY APE+ + +E+
Sbjct: 147 HRDLKTENLLLDGNMDIKLADFGFGNFYKSGEP---LSTWCGSPPYAAPEVFEGKEYEGP 203
Query: 188 PVDVWSCGIVLTAMLAGELPWDQPS--DSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKI 245
+D+WS G+VL ++ G LP+D P+ Q + + + + + +L+ ++
Sbjct: 204 QLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFF-----MSQDCESLIRRM 258
Query: 246 LVENPSARITIPDIKKDRWYN-KPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVN 304
LV +P+ RITI I++ RW +P G P ++ + + + + + V+
Sbjct: 259 LVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVD 318
Query: 305 SASSEENVKYSS 316
+ E+++ SS
Sbjct: 319 RQRTVESLQNSS 330
>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
Length = 559
Score = 157 bits (398), Expect = 2e-38
Identities = 94/266 (35%), Positives = 150/266 (56%), Gaps = 14/266 (5%)
Query: 11 LVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMK--RAVDCPENIKKEICINKMLNHENVV 68
L TLG G +G+V++ + +T VAVKI++ + R++D I++EI K+ H +++
Sbjct: 29 LGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHII 88
Query: 69 KFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITH 128
K Y + ++ +EY SGGELFD I + + E +++R F Q+++GV Y H + H
Sbjct: 89 KLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVH 148
Query: 129 RDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEP 188
RD+KPEN+LLD N KI+DFGL+ + + L CG+ Y APE++ R +
Sbjct: 149 RDLKPENVLLDAHMNAKIADFGLSNMM---SDGEFLRTSCGSPNYAAPEVISGRLYAGPE 205
Query: 189 VDVWSCGIVLTAMLAGELPWDQ---PSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKI 245
VD+WS G++L A+L G LP+D P+ + YLNP + ++LL +
Sbjct: 206 VDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNP------SVISLLKHM 259
Query: 246 LVENPSARITIPDIKKDRWYNKPLKK 271
L +P R TI DI++ W+ + L K
Sbjct: 260 LQVDPMKRATIKDIREHEWFKQDLPK 285
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 155 bits (391), Expect = 1e-37
Identities = 95/265 (35%), Positives = 146/265 (55%), Gaps = 16/265 (6%)
Query: 11 LVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMK--RAVDCPENIKKEICINKMLNHENVV 68
L TLG G +G+V++ +++T VAVKI++ + R++D IK+EI K+ H +++
Sbjct: 18 LGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHII 77
Query: 69 KFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITH 128
K Y ++ +EY SGGELFD I + E +A+R F Q+++ V Y H + H
Sbjct: 78 KLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVH 137
Query: 129 RDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEP 188
RD+KPEN+LLD N KI+DFGL+ + + L CG+ Y APE++ R +
Sbjct: 138 RDLKPENVLLDAHMNAKIADFGLSNMM---SDGEFLRTSCGSPNYAAPEVISGRLYAGPE 194
Query: 189 VDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKK----TYLNPWKKIDSAPLALLHK 244
VD+WSCG++L A+L G LP+D E+ KK + P S L+H
Sbjct: 195 VDIWSCGVILYALLCGTLPFD------DEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHM 248
Query: 245 ILVENPSARITIPDIKKDRWYNKPL 269
+ V+ P R TI DI++ W+ + L
Sbjct: 249 LQVD-PLKRATIKDIREHEWFKQDL 272
>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
Length = 1263
Score = 154 bits (389), Expect = 2e-37
Identities = 93/259 (35%), Positives = 146/259 (56%), Gaps = 11/259 (4%)
Query: 9 WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKK---EICINKMLNHE 65
+++ +T+G+G + V+ A + VT+ VA+KI+D K +D EN+KK E+ I KML H
Sbjct: 8 YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIID-KTQLD-EENLKKIFREVQIMKMLCHP 65
Query: 66 NVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIG 125
++++ Y + YL EY SGGE+FD + M E +A+R F Q++ V + H
Sbjct: 66 HIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN 125
Query: 126 ITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFH 185
I HRD+K ENLLLD N+KI+DFG + +F +LL CG+ PY APEL + +E+
Sbjct: 126 IVHRDLKAENLLLDANLNIKIADFGFSNLF---TPGQLLKTWCGSPPYAAPELFEGKEYD 182
Query: 186 AEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKI 245
VD+WS G+VL ++ G LP+D + Q + P+ + H +
Sbjct: 183 GPKVDIWSLGVVLYVLVCGALPFD--GSTLQNLRARVLSGKFRIPFFMSTECEHLIRH-M 239
Query: 246 LVENPSARITIPDIKKDRW 264
LV +P+ R+++ I K +W
Sbjct: 240 LVLDPNKRLSMEQICKHKW 258
>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
sapiens]
Length = 714
Score = 151 bits (382), Expect = 1e-36
Identities = 88/258 (34%), Positives = 143/258 (55%), Gaps = 8/258 (3%)
Query: 15 LGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVD---CPENIKKEICINKMLNHENVVKFY 71
LGEG++ +V+ ++ +T E VA+K++D KRA +N+++E I +M+ H N+ +
Sbjct: 68 LGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLL 127
Query: 72 GHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDI 131
N YL +E C GG L +I + E +A+R+ QL++ V +LH G+ HRD+
Sbjct: 128 DILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDL 187
Query: 132 KPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDV 191
K ENLLLDE +N+K+ DFGL+ + CG+ Y APELL R+++ +DV
Sbjct: 188 KIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKY-GPKIDV 246
Query: 192 WSCGIVLTAMLAGELPWD-QPSDSCQEYSDWKEKKTYLNPW-KKIDSAPLALLHKILVEN 249
WS G+ + AML G LP+ +P Y +K+ +NP ++ + ++ L +L +
Sbjct: 247 WSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKE--MNPLPTQLSTGAISFLRSLLEPD 304
Query: 250 PSARITIPDIKKDRWYNK 267
P R I +RW N+
Sbjct: 305 PVKRPNIQQALANRWLNE 322
>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 2 [Homo sapiens]
Length = 574
Score = 150 bits (378), Expect = 3e-36
Identities = 95/281 (33%), Positives = 152/281 (54%), Gaps = 29/281 (10%)
Query: 11 LVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMK--RAVDCPENIKKEICINKMLNHENVV 68
L TLG G +G+V++ + +T VAVKI++ + R++D I++EI K+ H +++
Sbjct: 29 LGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHII 88
Query: 69 KFYGHRREGNIQYLFLEYCSGGELFDRI-----EPDIG----------MPEPDAQRFFHQ 113
K Y + ++ +EY SGGELFD I + D+ + E +++R F Q
Sbjct: 89 KLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESRRLFQQ 148
Query: 114 LMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPY 173
+++GV Y H + HRD+KPEN+LLD N KI+DFGL+ + + L CG+ Y
Sbjct: 149 ILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM---SDGEFLRTSCGSPNY 205
Query: 174 VAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQ---PSDSCQEYSDWKEKKTYLNP 230
APE++ R + VD+WS G++L A+L G LP+D P+ + YLNP
Sbjct: 206 AAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNP 265
Query: 231 WKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKK 271
+ ++LL +L +P R TI DI++ W+ + L K
Sbjct: 266 ------SVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPK 300
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 148 bits (374), Expect = 9e-36
Identities = 84/262 (32%), Positives = 145/262 (55%), Gaps = 13/262 (4%)
Query: 9 WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPE--NIKKEICINKMLNHEN 66
++L +TLG+G YG+V+ A R + VA+K + + D + +I++EI I LNH +
Sbjct: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Query: 67 VVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGI 126
++ Y + + +EY S GEL+D I + E + + FF Q+++ V Y H G+
Sbjct: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174
Query: 127 THRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHA 186
HRD+K EN+LLD+ N+KI+DFGL+ +++ +++ L CG+ Y +PE++ R +
Sbjct: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQ---KDKFLQTFCGSPLYASPEIVNGRPYRG 231
Query: 187 EPVDVWSCGIVLTAMLAGELPWD--QPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHK 244
VD W+ G++L ++ G +P+D + ++ S + Y P + D+ L+
Sbjct: 232 PEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGE----YREPTQPSDAR--GLIRW 285
Query: 245 ILVENPSARITIPDIKKDRWYN 266
+L+ NP R TI DI W N
Sbjct: 286 MLMVNPDRRATIEDIANHWWVN 307
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 144 bits (364), Expect = 1e-34
Identities = 87/260 (33%), Positives = 135/260 (51%), Gaps = 8/260 (3%)
Query: 9 WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVV 68
++ +TLG GA+ EV LA + T + AVK + K +I+ EI + + + HEN+V
Sbjct: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIV 82
Query: 69 KFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITH 128
N YL ++ SGGELFDRI E DA Q++ V YLH +GI H
Sbjct: 83 ALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVH 142
Query: 129 RDIKPENLLL---DERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFH 185
RD+KPENLL DE + ISDFGL+ + + +++ CGT YVAPE+L ++ +
Sbjct: 143 RDLKPENLLYYSQDEESKIMISDFGLS---KMEGKGDVMSTACGTPGYVAPEVLAQKPY- 198
Query: 186 AEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNP-WKKIDSAPLALLHK 244
++ VD WS G++ +L G P+ +DS K + + +P W I + +
Sbjct: 199 SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRN 258
Query: 245 ILVENPSARITIPDIKKDRW 264
++ ++P+ R T + W
Sbjct: 259 LMEKDPNKRYTCEQAARHPW 278
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 144 bits (364), Expect = 1e-34
Identities = 87/260 (33%), Positives = 135/260 (51%), Gaps = 8/260 (3%)
Query: 9 WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVV 68
++ +TLG GA+ EV LA + T + AVK + K +I+ EI + + + HEN+V
Sbjct: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIV 82
Query: 69 KFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITH 128
N YL ++ SGGELFDRI E DA Q++ V YLH +GI H
Sbjct: 83 ALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVH 142
Query: 129 RDIKPENLLL---DERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFH 185
RD+KPENLL DE + ISDFGL+ + + +++ CGT YVAPE+L ++ +
Sbjct: 143 RDLKPENLLYYSQDEESKIMISDFGLS---KMEGKGDVMSTACGTPGYVAPEVLAQKPY- 198
Query: 186 AEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNP-WKKIDSAPLALLHK 244
++ VD WS G++ +L G P+ +DS K + + +P W I + +
Sbjct: 199 SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRN 258
Query: 245 ILVENPSARITIPDIKKDRW 264
++ ++P+ R T + W
Sbjct: 259 LMEKDPNKRYTCEQAARHPW 278
>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
Length = 648
Score = 142 bits (358), Expect = 7e-34
Identities = 89/259 (34%), Positives = 135/259 (52%), Gaps = 13/259 (5%)
Query: 13 QTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYG 72
+ +G+G + V+ +R T +A A+KI+D R + + EI I + L+H N+VK +
Sbjct: 360 RVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILIIQSLSHPNIVKLHE 419
Query: 73 HRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIK 132
YL LEY GG+LFD I + PEPDA L +V++H I HRD+K
Sbjct: 420 VYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHDKSIVHRDLK 479
Query: 133 PENLLL----DERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEP 188
PENLL+ D+ LK++DFGLA + R + +CGT YVAPE+L + + E
Sbjct: 480 PENLLVQRNEDKSTTLKLADFGLA-----KHVVRPIFTVCGTPTYVAPEILSEKGYGLE- 533
Query: 189 VDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKE--KKTYLNP-WKKIDSAPLALLHKI 245
VD+W+ G++L +L G P+ P E + + +L P W I A L+ ++
Sbjct: 534 VDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVSRL 593
Query: 246 LVENPSARITIPDIKKDRW 264
LV +P R T + + W
Sbjct: 594 LVVDPKKRYTAHQVLQHPW 612
>gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]
Length = 586
Score = 140 bits (352), Expect = 3e-33
Identities = 90/272 (33%), Positives = 140/272 (51%), Gaps = 18/272 (6%)
Query: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMK-------RAVDCPENIKKEICIN 59
+++ + +TLG GA GEV+LA R T + VA+KI+ + R D N++ EI I
Sbjct: 261 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 320
Query: 60 KMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVV 119
K LNH ++K + Y+ LE GGELFD++ + + E + +F+Q++ V
Sbjct: 321 KKLNHPCIIKIKNFF-DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 379
Query: 120 YLHGIGITHRDIKPENLLLDERDN---LKISDFGLATVFRYNNRERLLNKMCGTLPYVAP 176
YLH GI HRD+KPEN+LL ++ +KI+DFG + + L+ +CGT Y+AP
Sbjct: 380 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKIL---GETSLMRTLCGTPTYLAP 436
Query: 177 ELLKR--REFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNP--WK 232
E+L + VD WS G++L L+G P+ + K P W
Sbjct: 437 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 496
Query: 233 KIDSAPLALLHKILVENPSARITIPDIKKDRW 264
++ L L+ K+LV +P AR T + + W
Sbjct: 497 EVSEKALDLVKKLLVVDPKARFTTEEALRHPW 528
>gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]
Length = 543
Score = 140 bits (352), Expect = 3e-33
Identities = 90/272 (33%), Positives = 140/272 (51%), Gaps = 18/272 (6%)
Query: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMK-------RAVDCPENIKKEICIN 59
+++ + +TLG GA GEV+LA R T + VA+KI+ + R D N++ EI I
Sbjct: 218 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 277
Query: 60 KMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVV 119
K LNH ++K + Y+ LE GGELFD++ + + E + +F+Q++ V
Sbjct: 278 KKLNHPCIIKIKNFF-DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 336
Query: 120 YLHGIGITHRDIKPENLLLDERDN---LKISDFGLATVFRYNNRERLLNKMCGTLPYVAP 176
YLH GI HRD+KPEN+LL ++ +KI+DFG + + L+ +CGT Y+AP
Sbjct: 337 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKIL---GETSLMRTLCGTPTYLAP 393
Query: 177 ELLKR--REFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNP--WK 232
E+L + VD WS G++L L+G P+ + K P W
Sbjct: 394 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 453
Query: 233 KIDSAPLALLHKILVENPSARITIPDIKKDRW 264
++ L L+ K+LV +P AR T + + W
Sbjct: 454 EVSEKALDLVKKLLVVDPKARFTTEEALRHPW 485
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,988,679
Number of Sequences: 37866
Number of extensions: 886360
Number of successful extensions: 4270
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 713
Number of HSP's successfully gapped in prelim test: 97
Number of HSP's that attempted gapping in prelim test: 2009
Number of HSP's gapped (non-prelim): 927
length of query: 476
length of database: 18,247,518
effective HSP length: 106
effective length of query: 370
effective length of database: 14,233,722
effective search space: 5266477140
effective search space used: 5266477140
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.