Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 145275198
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
(1691 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 3603 0.0
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 1419 0.0
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens] 799 0.0
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 306 1e-82
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 295 2e-79
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 286 1e-76
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 285 2e-76
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 285 2e-76
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 282 2e-75
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 265 2e-70
gi|145309328 papilin [Homo sapiens] 261 4e-69
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 247 6e-65
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 245 2e-64
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 245 2e-64
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 245 3e-64
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 231 3e-60
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 229 1e-59
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 214 6e-55
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 208 4e-53
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 208 4e-53
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 200 1e-50
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 199 1e-50
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 199 2e-50
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 177 8e-44
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa... 176 1e-43
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 162 3e-39
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 155 2e-37
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s... 151 5e-36
gi|223718260 ADAMTS-like 2 precursor [Homo sapiens] 138 5e-32
gi|41281450 ADAMTS-like 2 precursor [Homo sapiens] 138 5e-32
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 3603 bits (9344), Expect = 0.0
Identities = 1691/1691 (100%), Positives = 1691/1691 (100%)
Query: 1 MASWTSPWWVLIGMVFMHSPLPQTTAEKSPGAYFLPEFALSPQGSFLEDTTGEQFLTYRY 60
MASWTSPWWVLIGMVFMHSPLPQTTAEKSPGAYFLPEFALSPQGSFLEDTTGEQFLTYRY
Sbjct: 1 MASWTSPWWVLIGMVFMHSPLPQTTAEKSPGAYFLPEFALSPQGSFLEDTTGEQFLTYRY 60
Query: 61 DDQTSRNTRSDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSN 120
DDQTSRNTRSDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSN
Sbjct: 61 DDQTSRNTRSDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSN 120
Query: 121 HDCPPDAEDFRAQQCSAYNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKV 180
HDCPPDAEDFRAQQCSAYNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKV
Sbjct: 121 HDCPPDAEDFRAQQCSAYNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKV 180
Query: 181 LDGTRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSP 240
LDGTRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSP
Sbjct: 181 LDGTRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSP 240
Query: 241 EKREENVIAVPLGSRSVRITVKGPAHLFIESKTLQGSKGEHSFNSPGVFLVENTTVEFQR 300
EKREENVIAVPLGSRSVRITVKGPAHLFIESKTLQGSKGEHSFNSPGVFLVENTTVEFQR
Sbjct: 241 EKREENVIAVPLGSRSVRITVKGPAHLFIESKTLQGSKGEHSFNSPGVFLVENTTVEFQR 300
Query: 301 GSERQTFKIPGPLMADFIFKTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQ 360
GSERQTFKIPGPLMADFIFKTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQ
Sbjct: 301 GSERQTFKIPGPLMADFIFKTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQ 360
Query: 361 LNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLP 420
LNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLP
Sbjct: 361 LNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLP 420
Query: 421 RWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCP 480
RWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCP
Sbjct: 421 RWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCP 480
Query: 481 KWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEK 540
KWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEK
Sbjct: 481 KWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEK 540
Query: 541 SPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQT 600
SPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQT
Sbjct: 541 SPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQT 600
Query: 601 ETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATC 660
ETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATC
Sbjct: 601 ETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATC 660
Query: 661 VGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCG 720
VGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCG
Sbjct: 661 VGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCG 720
Query: 721 VGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQ 780
VGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQ
Sbjct: 721 VGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQ 780
Query: 781 NRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQ 840
NRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQ
Sbjct: 781 NRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQ 840
Query: 841 RRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQMPECSKIKSEMKTKLGEQGPQILS 900
RRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQMPECSKIKSEMKTKLGEQGPQILS
Sbjct: 841 RRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQMPECSKIKSEMKTKLGEQGPQILS 900
Query: 901 VQRVYIQTREEKRINLTIGSRAYLLPNTSVIIKCPVRRFQKSLIQWEKDGRCLQNSKRLG 960
VQRVYIQTREEKRINLTIGSRAYLLPNTSVIIKCPVRRFQKSLIQWEKDGRCLQNSKRLG
Sbjct: 901 VQRVYIQTREEKRINLTIGSRAYLLPNTSVIIKCPVRRFQKSLIQWEKDGRCLQNSKRLG 960
Query: 961 ITKSGSLKIHGLAAPDIGVYRCIAGSAQETVVLKLIGTDNRLIARPALREPMREYPGMDH 1020
ITKSGSLKIHGLAAPDIGVYRCIAGSAQETVVLKLIGTDNRLIARPALREPMREYPGMDH
Sbjct: 961 ITKSGSLKIHGLAAPDIGVYRCIAGSAQETVVLKLIGTDNRLIARPALREPMREYPGMDH 1020
Query: 1021 SEANSLGVTWHKMRQMWNNKNDLYLDDDHISNQPFLRALLGHCSNSAGSTNSWELKNKQF 1080
SEANSLGVTWHKMRQMWNNKNDLYLDDDHISNQPFLRALLGHCSNSAGSTNSWELKNKQF
Sbjct: 1021 SEANSLGVTWHKMRQMWNNKNDLYLDDDHISNQPFLRALLGHCSNSAGSTNSWELKNKQF 1080
Query: 1081 EAAVKQGAYSMDTAQFDELIRNMSQLMETGEVSDDLASQLIYQLVAELAKAQPTHMQWRG 1140
EAAVKQGAYSMDTAQFDELIRNMSQLMETGEVSDDLASQLIYQLVAELAKAQPTHMQWRG
Sbjct: 1081 EAAVKQGAYSMDTAQFDELIRNMSQLMETGEVSDDLASQLIYQLVAELAKAQPTHMQWRG 1140
Query: 1141 IQEETPPAAQLRGETGSVSQSSHAKNSGKLTFKPKGPVLMRQSQPPSISFNKTINSRIGN 1200
IQEETPPAAQLRGETGSVSQSSHAKNSGKLTFKPKGPVLMRQSQPPSISFNKTINSRIGN
Sbjct: 1141 IQEETPPAAQLRGETGSVSQSSHAKNSGKLTFKPKGPVLMRQSQPPSISFNKTINSRIGN 1200
Query: 1201 TVYITKRTEVINILCDLITPSEATYTWTKDGTLLQPSVKIILDGTGKIQIQNPTRKEQGI 1260
TVYITKRTEVINILCDLITPSEATYTWTKDGTLLQPSVKIILDGTGKIQIQNPTRKEQGI
Sbjct: 1201 TVYITKRTEVINILCDLITPSEATYTWTKDGTLLQPSVKIILDGTGKIQIQNPTRKEQGI 1260
Query: 1261 YECSVANHLGSDVESSSVLYAEAPVILSVERNITKPEHNHLSVVVGGIVEAALGANVTIR 1320
YECSVANHLGSDVESSSVLYAEAPVILSVERNITKPEHNHLSVVVGGIVEAALGANVTIR
Sbjct: 1261 YECSVANHLGSDVESSSVLYAEAPVILSVERNITKPEHNHLSVVVGGIVEAALGANVTIR 1320
Query: 1321 CPVKGVPQPNITWLKRGGSLSGNVSLLFNGSLLLQNVSLENEGTYVCIATNALGKAVATS 1380
CPVKGVPQPNITWLKRGGSLSGNVSLLFNGSLLLQNVSLENEGTYVCIATNALGKAVATS
Sbjct: 1321 CPVKGVPQPNITWLKRGGSLSGNVSLLFNGSLLLQNVSLENEGTYVCIATNALGKAVATS 1380
Query: 1381 VLHLLERRWPESRIVFLQGHKKYILQATNTRTNSNDPTGEPPPQEPFWEPGNWSHCSATC 1440
VLHLLERRWPESRIVFLQGHKKYILQATNTRTNSNDPTGEPPPQEPFWEPGNWSHCSATC
Sbjct: 1381 VLHLLERRWPESRIVFLQGHKKYILQATNTRTNSNDPTGEPPPQEPFWEPGNWSHCSATC 1440
Query: 1441 GHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARWFTSVWSQCSVSCG 1500
GHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARWFTSVWSQCSVSCG
Sbjct: 1441 GHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARWFTSVWSQCSVSCG 1500
Query: 1501 EGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPCVQWEPGNRCPGRCMGR 1560
EGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPCVQWEPGNRCPGRCMGR
Sbjct: 1501 EGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPCVQWEPGNRCPGRCMGR 1560
Query: 1561 AVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGACDVCWHTGPWKPCTAACGRGFQSR 1620
AVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGACDVCWHTGPWKPCTAACGRGFQSR
Sbjct: 1561 AVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGACDVCWHTGPWKPCTAACGRGFQSR 1620
Query: 1621 KVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSCDRDCTDTTHYCMFVKHLNLCSLDRY 1680
KVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSCDRDCTDTTHYCMFVKHLNLCSLDRY
Sbjct: 1621 KVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSCDRDCTDTTHYCMFVKHLNLCSLDRY 1680
Query: 1681 KQRCCQSCQEG 1691
KQRCCQSCQEG
Sbjct: 1681 KQRCCQSCQEG 1691
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 1419 bits (3673), Expect = 0.0
Identities = 740/1751 (42%), Positives = 1002/1751 (57%), Gaps = 139/1751 (7%)
Query: 64 TSRNTRSDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDC 123
+SR RS+ED+DG WDAWG WS+CSRTCGGGASYSLRRCL+ ++CEG+NIRY+TCSN DC
Sbjct: 22 SSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDC 81
Query: 124 PPDAEDFRAQQCSAYNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLDG 183
PP+A DFRAQQCSA+NDV++ G +YEWLP NDP PC+LKC A+G LVVELAPKVLDG
Sbjct: 82 PPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDG 141
Query: 184 TRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKR 243
TRC T+SLDMCISG+CQ VGCD QLGS KEDNCGVC GDGSTCRLVRGQ KS +S K
Sbjct: 142 TRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKS 201
Query: 244 EENVIAVPLGSRSVRITVKGPAHLFIESKTLQGSKGEHSFNSPGVFLVENTTVEFQRGSE 303
++ V+A+P GSR +R+ +KGP HL++E+KTLQG+KGE+S +S G FLV+N++V+FQ+ +
Sbjct: 202 DDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDFQKFPD 261
Query: 304 RQTFKIPGPLMADFIFKTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQLNS 363
++ ++ GPL ADFI K R + + DS VQF FYQPI H+WR+TDFFPC+ TCGGGYQL S
Sbjct: 262 KEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTS 321
Query: 364 AECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWE 423
AEC D+R RVV D YCHYYPEN+KPKPKL+EC++DPCP+SDG+K+IMPYD + PLPRWE
Sbjct: 322 AECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIMPYDLYHPLPRWE 381
Query: 424 HNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPKWI 483
PWTACS SCGGGIQ R+ CVEE + G + VEEWKCMY PK + Q CN+FDCPKW+
Sbjct: 382 ATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPKWL 441
Query: 484 AMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPV 543
A EWS CTVTCG+GLRYRVVLCI+HRG H GGC+P+ K HIKEEC++P PCYKPKEK PV
Sbjct: 442 AQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIVPTPCYKPKEKLPV 501
Query: 544 EAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETE 603
EAKLPW KQAQELEE +EEP+FIPE WSAC+ TCG G QVR V+C+VLL+F+Q+ +
Sbjct: 502 EAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVAD 561
Query: 604 LPEEECEGPKLPTERPCLLEAC-----DESPASRELDIPLPEDSETTYDWEYAGFTPCTA 658
LP +ECEGPK ++R C C + +P + +D + YDWEY GFT C+
Sbjct: 562 LPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSE 621
Query: 659 TCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSAT 718
+C GG QEA+ CL+ QT++ ++LC RPP + ++CN +PCP RW +G W PCS T
Sbjct: 622 SCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLT 681
Query: 719 CGVGIQTRDVYCLH-----PGETPAPPEE-CRDEKPHALQACNQFDCPPGWHIEEWQQCS 772
CGVG+QTRDV+C H ET +E CR KP +QACN+F+CPP W+ +WQ CS
Sbjct: 682 CGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCS 741
Query: 773 RTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCS 832
RTCGGG Q R V C+Q + DGSFL L + C K + ++C + DCP + DW++CS
Sbjct: 742 RTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDDCPSEWLLSDWTECS 801
Query: 833 VSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQMPECSKIKSEMKTKLG 892
SCG G Q R +C+++ G ++ +C LP +R C + C++ TK
Sbjct: 802 TSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCMLATCAR-PGRPSTK-- 858
Query: 893 EQGPQILSVQRVYIQTREEKRINLTIGSRAYLLPNTSVIIKCPVRRFQKSLIQWEKDGRC 952
P I + ++VYIQTR +++++ +G AYLLP T+V+++CP RR +K LI WEKDG+
Sbjct: 859 -HSPHIAAARKVYIQTRRQRKLHFVVGGFAYLLPKTAVVLRCPARRVRKPLITWEKDGQH 917
Query: 953 LQNSKRLGITKSGSLKIHGLAAPDIGVYRCIAGSAQETVVLKLIGTDNRLIARP------ 1006
L +S + + G LKIH L D GVY C AG A+E V+KLIG + +L+ARP
Sbjct: 918 LISSTHVTVAPFGYLKIHRLKPSDAGVYTCSAGPAREHFVIKLIGGNRKLVARPLSPRSE 977
Query: 1007 ----ALREPMREYPGMDHSEANSLGVTWHKMRQMWNNKNDLYLDDDHISNQPFLRALLGH 1062
A R+ + H N + K + N DD +S G
Sbjct: 978 EEVLAGRKGGPKEALQTHKHQNGIFSNGSKAEKRGLAANPGSRYDDLVSRLLEQGGWPGE 1037
Query: 1063 C-----SNSAGSTNSWELKNKQFEAAVKQGAYSMDTAQ--FDELIRNMSQLMETGEVSDD 1115
+ + N+ ++ E + ++M T Q D+++ N+SQ E E+ D
Sbjct: 1038 LLASWEAQDSAERNTTSEEDPGAEQVLLHLPFTMVTEQRRLDDILGNLSQQPE--ELRDL 1095
Query: 1116 LASQLIYQLVAELAKAQPTHM-------QWRGIQEETPPAAQLRGETGSVSQSSHAKNSG 1168
+ L+ QL E+ ++ H + R P + G + S+ SS G
Sbjct: 1096 YSKHLVAQLAQEIFRSHLEHQDTLLKPSERRTSPVTLSPHKHVSGFSSSLRTSSTGDAGG 1155
Query: 1169 KLTFKPKGPVLMRQSQPPSISFNKTINSRIGNTVYITKRTEVINILCDLITPSEATYTWT 1228
+ P ++R+ + + +G TV + T + + C+ I T +W
Sbjct: 1156 GSRRPHRKPTILRKISAAQQLSASEVVTHLGQTVALASGTLSVLLHCEAIGHPRPTISWA 1215
Query: 1229 KDGTLLQPSVKIILDGTGKIQIQNPTRKEQGIYECSVANHLGSDVESSSVLYAEAPVILS 1288
++G +Q S +I+L +QI P + G Y C+ N LG D S +V A P++ +
Sbjct: 1216 RNGEEVQFSDRILLQPDDSLQILAPVEADVGFYTCNATNALGYDSVSIAVTLAGKPLVKT 1275
Query: 1289 VERNITKPEHNHLSVVVGGIVEAALGANVTIRCPVKGVPQPNITWLKRGGSLSGNVSLLF 1348
+ E ++V +G ++ G NVTI C V GVP+ +TW + L G+ L
Sbjct: 1276 SRMTVINTEKPAVTVDIGSTIKTVQGVNVTINCQVAGVPEAEVTWFRNKSKL-GSPHHLH 1334
Query: 1349 NGSLLLQNVSLENEGTYVCIATNALGKAVATSVLHLLERRWPESRIVFLQGHKKYILQAT 1408
GSLLL NVS ++G Y C A N G+ ++ L +L+ +++ ++ +L AT
Sbjct: 1335 EGSLLLTNVSSSDQGLYSCRAANLHGELTESTQLLILDPPQVPTQLEDIRA----LLAAT 1390
Query: 1409 NTRTNSNDPTGEPPPQEPFWEPGN-----------------WSH-------CSATCGHLG 1444
N P + +PGN W H + H+
Sbjct: 1391 G--PNLPSVLTSPLGTQLVLDPGNSALLGCPIKGHPVPNITWFHGGQPIVTATGLTHHIL 1448
Query: 1445 ARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARWFTSVWSQCSVSCG-EGY 1503
A Q Q +G E C + + ++ W + CS SCG G
Sbjct: 1449 AAGQILQVANLSGGSQGEFSCLAQNEAGVLMQKASLVIQDYWWSVDRLATCSASCGNRGV 1508
Query: 1504 HSRQVTC--KRTKAN-----GTVQ-VVSPRACAPKDRP---------------------- 1533
++ C T+ N G V+ V P AC +D P
Sbjct: 1509 QQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWMVTSWSACTRSCGGGVQTR 1568
Query: 1534 -----------------------LGRKPCFGHPC-----VQW--EPGNRCPGRCMGRAVR 1563
+ ++P C V+W +C G C+G +
Sbjct: 1569 RVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCVEWAFSSWGQCNGPCIGPHLA 1628
Query: 1564 MQQRHTACQHNSS----DSNCDDRKRPTLRRNCTSGACDVCWHTGPWKPCTAACGR-GFQ 1618
+Q R CQ C RP +NC S AC V W W CTA CG GFQ
Sbjct: 1629 VQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQ 1688
Query: 1619 SRKVDCIHTRSCKPVAKRHCVQKKKPISWRHC-LGPSCDRDCTDTTHYCMFVKHLNLCSL 1677
SR+V+C+H R+ K V + C +P +W+ C + P + +C DTT YC VK L LC L
Sbjct: 1689 SRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPCENMECRDTTRYCEKVKQLKLCQL 1748
Query: 1678 DRYKQRCCQSC 1688
++K RCC +C
Sbjct: 1749 SQFKSRCCGTC 1759
>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
Length = 525
Score = 799 bits (2063), Expect = 0.0
Identities = 347/504 (68%), Positives = 417/504 (82%)
Query: 64 TSRNTRSDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDC 123
+SR RS+ED+DG WDAWG WS+CSRTCGGGASYSLRRCL+ ++CEG+NIRY+TCSN DC
Sbjct: 22 SSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDC 81
Query: 124 PPDAEDFRAQQCSAYNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLDG 183
PP+A DFRAQQCSA+NDV++ G +YEWLP NDP PC+LKC A+G LVVELAPKVLDG
Sbjct: 82 PPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDG 141
Query: 184 TRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKR 243
TRC T+SLDMCISG+CQ VGCD QLGS KEDNCGVC GDGSTCRLVRGQ KS +S K
Sbjct: 142 TRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKS 201
Query: 244 EENVIAVPLGSRSVRITVKGPAHLFIESKTLQGSKGEHSFNSPGVFLVENTTVEFQRGSE 303
++ V+A+P GSR +R+ +KGP HL++E+KTLQG+KGE+S +S G FLV+N++V+FQ+ +
Sbjct: 202 DDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDFQKFPD 261
Query: 304 RQTFKIPGPLMADFIFKTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQLNS 363
++ ++ GPL ADFI K R + + DS VQF FYQPI H+WR+TDFFPC+ TCGGGYQL S
Sbjct: 262 KEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTS 321
Query: 364 AECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWE 423
AEC D+R RVV D YCHYYPEN+KPKPKL+EC++DPCP+SDG+K+IMPYD + PLPRWE
Sbjct: 322 AECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIMPYDLYHPLPRWE 381
Query: 424 HNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPKWI 483
PWTACS SCGGGIQ R+ CVEE + G + VEEWKCMY PK + Q CN+FDCPKW+
Sbjct: 382 ATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPKWL 441
Query: 484 AMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPV 543
A EWS CTVTCG+GLRYRVVLCI+HRG H GGC+P+ K HIKEEC++P PCYKPKEK PV
Sbjct: 442 AQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIVPTPCYKPKEKLPV 501
Query: 544 EAKLPWLKQAQELEETRIATEEPT 567
EAKLPW KQAQELEE +EEP+
Sbjct: 502 EAKLPWFKQAQELEEGAAVSEEPS 525
Score = 99.8 bits (247), Expect = 2e-20
Identities = 58/164 (35%), Positives = 75/164 (45%), Gaps = 26/164 (15%)
Query: 648 WEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVH---RPPAMSQACNTEPCP 704
W F PC+ATC GG+Q A C +++ + V D C +P Q CN +PCP
Sbjct: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
Query: 705 -----------------PRWHVGSWGPCSATCGVGIQTRDVYCLH---PGETPAPPE-EC 743
PRW W CS++CG GIQ+R V C+ G + E +C
Sbjct: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
Query: 744 R-DEKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTC 786
K Q CN FDCP W +EW C+ TCG G + R V C
Sbjct: 421 MYTPKMPIAQPCNIFDCPK-WLAQEWSPCTVTCGQGLRYRVVLC 463
Score = 82.8 bits (203), Expect = 3e-15
Identities = 57/172 (33%), Positives = 74/172 (43%), Gaps = 29/172 (16%)
Query: 701 EPCPPRWHVGSWGPCSATCGVGIQTRDVYC--LHPGETPAP------PEECRDEKPHALQ 752
+P RW + PCSATCG G Q C L A PE + KP LQ
Sbjct: 295 QPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKP-KPK-LQ 352
Query: 753 ACNQFDCP-----------------PGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSF 795
CN CP P W W CS +CGGG Q+R V+C + G
Sbjct: 353 ECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHV 412
Query: 796 LNLSDELCQ-GPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVC 846
++ + C PK + C DCP LA +WS C+V+CG G++ R +C
Sbjct: 413 TSVEEWKCMYTPKMPIAQPCNIFDCPKWLA-QEWSPCTVTCGQGLRYRVVLC 463
Score = 73.2 bits (178), Expect = 2e-12
Identities = 58/193 (30%), Positives = 85/193 (44%), Gaps = 29/193 (15%)
Query: 576 CSTTCGPGVQVREVKCRVLLTFTQTETEL----PEEECEGPKLPTERPCLLEACDESPAS 631
CS TCG G Q+ +C L + + PE PKL + C L+ C S
Sbjct: 309 CSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKL---QECNLDPCPASDGY 365
Query: 632 REL---DI--PLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQ---QTVNDS 683
+++ D+ PLP WE +T C+++C GG Q C+ Q +V +
Sbjct: 366 KQIMPYDLYHPLPR-------WEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEW 418
Query: 684 LCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCL-HPGETPAPPEE 742
C + P ++Q CN CP +W W PC+ TCG G++ R V C+ H G
Sbjct: 419 KCMYTPKMP-IAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTG---G 473
Query: 743 CRDE-KPHALQAC 754
C + KPH + C
Sbjct: 474 CSPKTKPHIKEEC 486
Score = 68.9 bits (167), Expect = 4e-11
Identities = 46/135 (34%), Positives = 67/135 (49%), Gaps = 18/135 (13%)
Query: 1426 PFWEPGNWSHCSATCGHLGARIQRPQCVMANGQ----EVSEALCDHLQK-PLAGFEPCNI 1480
P WE W+ CS++CG G + + CV + Q V E C + K P+A +PCNI
Sbjct: 378 PRWEATPWTACSSSCGG-GIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIA--QPCNI 434
Query: 1481 RDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCF 1540
DCP +W WS C+V+CG+G R V C + T C+PK +P ++ C
Sbjct: 435 FDCP-KWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHT------GGCSPKTKPHIKEECI 487
Query: 1541 -GHPCVQWEPGNRCP 1554
PC ++P + P
Sbjct: 488 VPTPC--YKPKEKLP 500
Score = 64.7 bits (156), Expect = 7e-10
Identities = 46/188 (24%), Positives = 74/188 (39%), Gaps = 25/188 (13%)
Query: 1428 WEPGNWSHCSATCGHLGARIQRPQCV-MANGQEVSEALCDHLQ---KPLAGFEPCNIRDC 1483
W ++ CSATCG G ++ +C + + + V++ C + KP + CN+ C
Sbjct: 301 WRETDFFPCSATCGG-GYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPC 359
Query: 1484 PA-----------------RWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRA 1526
PA RW + W+ CS SCG G SR V+C G V V
Sbjct: 360 PASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWK 419
Query: 1527 CAPKDRPLGRKPCFGHPCVQW--EPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRK 1584
C + +PC C +W + + C C G+ +R + C +
Sbjct: 420 CMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTC-GQGLRYRVVLCIDHRGMHTGGCSPKT 478
Query: 1585 RPTLRRNC 1592
+P ++ C
Sbjct: 479 KPHIKEEC 486
Score = 59.3 bits (142), Expect = 3e-08
Identities = 49/189 (25%), Positives = 67/189 (35%), Gaps = 44/189 (23%)
Query: 1486 RWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRAC---------APKDRPLGR 1536
RW + + CS +CG GY C ++N +VV+ + C PK +
Sbjct: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSN---RVVADQYCHYYPENIKPKPKLQECNL 356
Query: 1537 KPC-------------FGHPCVQWE--PGNRCPGRCMGRAVRMQQRHTACQHNSSDSN-- 1579
PC HP +WE P C C G +Q R +C +
Sbjct: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGG---IQSRAVSCVEEDIQGHVT 413
Query: 1580 ------CDDRKRPTLRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCI-----HTR 1628
C + + + C C W W PCT CG+G + R V CI HT
Sbjct: 414 SVEEWKCMYTPKMPIAQPCNIFDCPK-WLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTG 472
Query: 1629 SCKPVAKRH 1637
C P K H
Sbjct: 473 GCSPKTKPH 481
Score = 58.9 bits (141), Expect = 4e-08
Identities = 51/224 (22%), Positives = 84/224 (37%), Gaps = 32/224 (14%)
Query: 481 KWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEK 540
+W ++ C+ TCG G + C + R V H E + P P +
Sbjct: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVA---DQYCHYYPENIKPKPKLQECNL 356
Query: 541 SPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQT 600
P A + +++ + P + PW+ACS++CG G+Q R V C V
Sbjct: 357 DPCPASDGY----KQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSC-VEEDIQGH 411
Query: 601 ETELPEEEC-EGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTAT 659
T + E +C PK+P +PC + C + W ++PCT T
Sbjct: 412 VTSVEEWKCMYTPKMPIAQPCNIFDCPK--------------------WLAQEWSPCTVT 451
Query: 660 CVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPC 703
C G + + +C+ + T C +P + PC
Sbjct: 452 CGQGLRYRVVLCIDHRGMHTGG---CSPKTKPHIKEECIVPTPC 492
Score = 54.3 bits (129), Expect = 1e-06
Identities = 38/143 (26%), Positives = 54/143 (37%), Gaps = 27/143 (18%)
Query: 763 WHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQ------GPKASSHKSCAR 816
W ++ CS TCGGG Q C L ++ ++D+ C PK + C
Sbjct: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRV---VADQYCHYYPENIKPKPKLQE-CNL 356
Query: 817 TDCP-----------------PHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLS 859
CP P W+ CS SCG GIQ R C +G +
Sbjct: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVE 416
Query: 860 EMMCRDLPGLPLVRSCQMPECSK 882
E C P +P+ + C + +C K
Sbjct: 417 EWKCMYTPKMPIAQPCNIFDCPK 439
Score = 41.6 bits (96), Expect = 0.007
Identities = 21/65 (32%), Positives = 30/65 (46%), Gaps = 12/65 (18%)
Query: 768 WQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGD 827
W +CSRTCGGG C LS + C+G + +++C+ DCPP
Sbjct: 42 WSECSRTCGGGASYSLRRC-----------LSSKSCEG-RNIRYRTCSNVDCPPEAGDFR 89
Query: 828 WSKCS 832
+CS
Sbjct: 90 AQQCS 94
Score = 36.6 bits (83), Expect = 0.21
Identities = 14/38 (36%), Positives = 21/38 (55%)
Query: 1601 WHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHC 1638
W + PC+A CG G+Q +C RS + VA ++C
Sbjct: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYC 338
Score = 31.2 bits (69), Expect = 8.9
Identities = 20/63 (31%), Positives = 25/63 (39%), Gaps = 8/63 (12%)
Query: 710 GSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQ 769
G W CS TCG G CL + C + + + C+ DCPP Q
Sbjct: 40 GPWSECSRTCGGGASYSLRRCL-------SSKSC-EGRNIRYRTCSNVDCPPEAGDFRAQ 91
Query: 770 QCS 772
QCS
Sbjct: 92 QCS 94
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 306 bits (783), Expect = 1e-82
Identities = 256/929 (27%), Positives = 363/929 (39%), Gaps = 192/929 (20%)
Query: 75 DGNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPPDAE 128
+G W W +S CSRTCGGG + RRC G C G+ +++++C+ CP +
Sbjct: 556 NGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQ 615
Query: 129 DFRAQQCSAYN----DVQYQGHYYEWLPRYNDPAAP--CALKCHAQGQNLVVELAPKVLD 182
DFR +QCS +N D+ WLPRY+ C L C G N L V D
Sbjct: 616 DFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVED 675
Query: 183 GTRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQ-SKSHVSPE 241
GT C T++ D+C+ G C A GCD L S+AK D CGVC GD S+C+ + G + SH
Sbjct: 676 GTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNSSHYG-- 733
Query: 242 KREENVIAVPLGSRSVRITVKGPAHLFIES-KTLQGSKGEHSFNSPGVFLVENTTVEFQR 300
V+ +P G+ +V I + +S L ++G FN G FL+ + E
Sbjct: 734 --YNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNFLFN--GNFLLSTSKKEINV 789
Query: 301 GSERQTFKIPGPLMADFIFKTRYTAAKDSVVQFF----FYQPISHQ------WRQTDFFP 350
R + G A + K+ ++Q Y P H ++D F
Sbjct: 790 QGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIPLEERSDMFT 849
Query: 351 ---------CTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMD-- 399
CT C G Q + C+ VV D C + P P + C+ D
Sbjct: 850 WDPYGPWEGCTKMC-QGLQRRNITCIHKSDHSVVSDKECDHLP---LPSFVTQSCNTDCE 905
Query: 400 ---------PCPS--SDGFKEI----MPY----------------DHFQP---------- 418
C S G++ + M Y D +P
Sbjct: 906 LRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNC 965
Query: 419 -LPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLF 477
RW ++ W+ CS SCGGG + R C+ H ++ + +C + + CN F
Sbjct: 966 VFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGH----RLADNECQELSR-VTRENCNEF 1020
Query: 478 DCPKWIAMEWSQCTVTCGRGLRYRVVLC---INHRGEHVGGCNPQLKLHIKEECVIPIPC 534
CP W A EWS+C VTCG+G + R V C ++H + G CN
Sbjct: 1021 SCPSWAASEWSECLVTCGKGTKQRQVWCQLNVDHLSD--GFCNSST-------------- 1064
Query: 535 YKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVL 594
KP+ SP E Q PW C+TTCG G Q+R+VKC
Sbjct: 1065 -KPESLSPCELHTCASWQV-----------------GPWGPCTTTCGHGYQMRDVKCVNE 1106
Query: 595 LTFTQTETELPEEECEGPKLPTER-PCLLEACDESPASRELDIPLPEDSETTYDWEYAGF 653
L L + EC P++R C+L C +P + W + +
Sbjct: 1107 L----ASAVLEDTECHEASRPSDRQSCVLTPCSFISKLETALLPTVLIKKMA-QWRHGSW 1161
Query: 654 TPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWG 713
TPC+ +C G Q C + ++S C + R PA C T PC W G W
Sbjct: 1162 TPCSVSCGRGTQARYVSC-RDALDRIADESYCAHLPR-PAEIWDCFT-PC-GEWQAGDWS 1217
Query: 714 PCSATCGVGIQTRDVYCLHPGETPAPPEECRDE-KPHALQACNQFDCPPG---------- 762
PCSA+CG G TR V C++ + P C E +P Q C+ CPP
Sbjct: 1218 PCSASCGHGKTTRQVLCMNYHQ-PIDENYCDPEVRPLMEQECSLAACPPAHSHFPSSPVQ 1276
Query: 763 -------------------------------WHIEEWQQCSRTCGGGTQNRRVTCRQLLT 791
W W CS +C GG Q+R V C+
Sbjct: 1277 PSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQD--E 1334
Query: 792 DGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAA 851
+G + D + P+ + C C P G+W +CS +CG GI+ R +CQ
Sbjct: 1335 NGQSASYCDAASKPPEL---QQCGPGPC-PQWNYGNWGECSQTCGGGIKSRLVICQFPNG 1390
Query: 852 KGRRIPLSEMMCRDLPGLPLVRSCQMPEC 880
+ L + C + P V C M C
Sbjct: 1391 Q----ILEDHNCEIVNKPPSVIQCHMHAC 1415
Score = 233 bits (594), Expect = 1e-60
Identities = 161/559 (28%), Positives = 247/559 (44%), Gaps = 65/559 (11%)
Query: 343 WRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCP 402
W+ + PCT TCG GYQ+ +CV+ V+ D CH E +P + + C + PC
Sbjct: 1080 WQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECH---EASRPSDR-QSCVLTPCS 1135
Query: 403 SSDGFKE-IMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWK 461
+ ++P + + +W H WT CSVSCG G Q R C + +E
Sbjct: 1136 FISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDR----IADESY 1191
Query: 462 CMYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCIN-HRGEHVGGCNPQL 520
C + P+P + C C +W A +WS C+ +CG G R VLC+N H+ C+P++
Sbjct: 1192 CAHLPRPAEIWDC-FTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEV 1250
Query: 521 KLHIKEECVIPI--PCYKPKEKSPVEAKLPW---LKQAQELEETRIATEEPT-----FIP 570
+ +++EC + P + SPV+ L Q+LE+ P+ +
Sbjct: 1251 RPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRT 1310
Query: 571 EPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPA 630
PW +CS++C G+Q R V C Q E C+ P E L+ C P
Sbjct: 1311 GPWGSCSSSCSGGLQHRAVVC-------QDENGQSASYCDAASKPPE----LQQCGPGPC 1359
Query: 631 SRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHR 690
+ W Y + C+ TC GG + + +C Q + D C++V++
Sbjct: 1360 PQ---------------WNYGNWGECSQTCGGGIKSRLVIC-QFPNGQILEDHNCEIVNK 1403
Query: 691 PPAMSQACNTEPCPP--RWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRD-EK 747
PP++ Q C+ CP WH W CSA+CG G + R+V+C+ + C +K
Sbjct: 1404 PPSVIQ-CHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQK 1462
Query: 748 PHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELC-QGP 806
P +AC C P W W +CS TCG G Q R V CR L G + +E+C Q
Sbjct: 1463 PPTHKACRSVRC-PSWKANSWNECSVTCGSGVQQRDVYCR-LKGVGQVV---EEMCDQST 1517
Query: 807 KASSHKSCARTDCPPHLAVGDWS-KCSVSCGVGIQRRKQVCQRLAAKGRRI-PLSEMMCR 864
+ S + C DC H + CS SC RK QR+ +I ++E++
Sbjct: 1518 RPCSQRRCWSQDCVQHKGMERGRLNCSTSC-----ERKDSHQRMECTDNQIRQVNEIVYN 1572
Query: 865 DLPGLPLVRSCQMPECSKI 883
++C+ P C+ I
Sbjct: 1573 SSTISLTSKNCRNPPCNYI 1591
Score = 199 bits (507), Expect = 1e-50
Identities = 169/622 (27%), Positives = 247/622 (39%), Gaps = 121/622 (19%)
Query: 342 QWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPC 401
+W +++ C+ +CGGG + + C++ R+ D+ C + + C+ C
Sbjct: 969 RWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLA-DNECQELSRVTR-----ENCNEFSC 1022
Query: 402 PSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWK 461
PS W + W+ C V+CG G ++R C H + +
Sbjct: 1023 PS------------------WAASEWSECLVTCGKGTKQRQVWCQLNVDH-----LSDGF 1059
Query: 462 CMYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHV---GGCNP 518
C + KP+ + C L C W W CT TCG G + R V C+N V C+
Sbjct: 1060 CNSSTKPESLSPCELHTCASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHE 1119
Query: 519 QLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEET------------------- 559
+ ++ CV+ + K ++ + + K AQ +
Sbjct: 1120 ASRPSDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSC 1179
Query: 560 -----RIATEEP-TFIPEP-----------------WSACSTTCGPGVQVREVKCRVLLT 596
RIA E +P P WS CS +CG G R+V C +
Sbjct: 1180 RDALDRIADESYCAHLPRPAEIWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLC---MN 1236
Query: 597 FTQTETELPEEECEGPKLPT-ERPCLLEACD-------ESPA--SRELDIPLP-----ED 641
+ Q + E C+ P E+ C L AC SP S L LP ED
Sbjct: 1237 YHQP---IDENYCDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLED 1293
Query: 642 SETTY--------DWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPA 693
+E W + C+++C GG Q VC Q + + S CD +PP
Sbjct: 1294 NENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVC---QDENGQSASYCDAASKPPE 1350
Query: 694 MSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECR-DEKPHALQ 752
+ Q C PCP +W+ G+WG CS TCG GI++R V C P C KP ++
Sbjct: 1351 LQQ-CGPGPCP-QWNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVI 1408
Query: 753 ACNQFDCPP--GWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELC-QGPKAS 809
C+ CP WH E W CS +CG G + R V C D L D C Q K
Sbjct: 1409 QCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFC----IDQFQRKLEDTNCSQVQKPP 1464
Query: 810 SHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGL 869
+HK+C CP A W++CSV+CG G+Q+R C RL G+ + E MC
Sbjct: 1465 THKACRSVRCPSWKA-NSWNECSVTCGSGVQQRDVYC-RLKGVGQVV---EEMCDQSTRP 1519
Query: 870 PLVRSCQMPECSKIKSEMKTKL 891
R C +C + K + +L
Sbjct: 1520 CSQRRCWSQDCVQHKGMERGRL 1541
Score = 133 bits (335), Expect = 1e-30
Identities = 124/501 (24%), Positives = 186/501 (37%), Gaps = 119/501 (23%)
Query: 341 HQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDP 400
+QWR + C+ +C GG Q + C D + YC + P+L++C P
Sbjct: 1306 NQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSA---SYC----DAASKPPELQQCGPGP 1358
Query: 401 CPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEW 460
CP +W + W CS +CGGGI+ R +C + +G+IL E+
Sbjct: 1359 CP------------------QWNYGNWGECSQTCGGGIKSRLVIC--QFPNGQIL--EDH 1396
Query: 461 KCMYAPKPKVMQTCNLFDCP---KWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCN 517
C KP + C++ CP W W+ C+ +CG+G +YR V CI+
Sbjct: 1397 NCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQF-------- 1448
Query: 518 PQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACS 577
Q KL + P P K+ + P K W+ CS
Sbjct: 1449 -QRKLEDTNCSQVQKP---PTHKACRSVRCPSWK------------------ANSWNECS 1486
Query: 578 TTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLP-TERPCLLEACDESPASRELDI 636
TCG GVQ R+V CR+ + ++ EE C+ P ++R C + C +
Sbjct: 1487 VTCGSGVQQRDVYCRL-----KGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGMER--- 1538
Query: 637 PLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQ 696
G C+ +C C Q +Q VN+ + + S+
Sbjct: 1539 ---------------GRLNCSTSCERKDSHQRMECTDNQIRQ-VNEIVYNS-STISLTSK 1581
Query: 697 ACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQ 756
C PC C+ CG + R YC E P+ + K H L+
Sbjct: 1582 NCRNPPCNYIVVTADSSQCANNCGFSYRQRITYCT---EIPS----TKKHKLHRLRPIVY 1634
Query: 757 FDCP-----------------PGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLS 799
+CP W + +W +CS TCG G R+V C + G LS
Sbjct: 1635 QECPVVPSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKC--ITKHG----LS 1688
Query: 800 DELCQGP-KASSHKSCARTDC 819
+LC K + K C DC
Sbjct: 1689 SDLCLNHLKPGAQKKCYANDC 1709
Score = 121 bits (304), Expect = 5e-27
Identities = 93/328 (28%), Positives = 141/328 (42%), Gaps = 46/328 (14%)
Query: 572 PWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPAS 631
PW C+ C G+Q R + C + + ++EC+ LP+ + ++C+
Sbjct: 855 PWEGCTKMC-QGLQRRNITC----IHKSDHSVVSDKECDHLPLPS---FVTQSCNTDCEL 906
Query: 632 RELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLH--IQTQQTV--NDSLCDM 687
R W G + C++ C G++ C+ I QTV +D C
Sbjct: 907 R---------------WHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGD 951
Query: 688 VHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEK 747
+PP + C+ RWH W CS +CG G ++R+ YC++ EC++
Sbjct: 952 QLKPPTQ-ELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELS 1010
Query: 748 PHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPK 807
+ CN+F C P W EW +C TCG GT+ R+V C QL D +LSD C
Sbjct: 1011 RVTRENCNEFSC-PSWAASEWSECLVTCGKGTKQRQVWC-QLNVD----HLSDGFCN--- 1061
Query: 808 ASSHKSCARTDCPPHLA----VGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMC 863
SS K + + C H VG W C+ +CG G Q R C A L + C
Sbjct: 1062 -SSTKPESLSPCELHTCASWQVGPWGPCTTTCGHGYQMRDVKCVNELASA---VLEDTEC 1117
Query: 864 RDLPGLPLVRSCQMPECSKIKSEMKTKL 891
+ +SC + CS I S+++T L
Sbjct: 1118 HEASRPSDRQSCVLTPCSFI-SKLETAL 1144
Score = 107 bits (267), Expect = 1e-22
Identities = 74/265 (27%), Positives = 106/265 (40%), Gaps = 42/265 (15%)
Query: 1420 EPPPQE--------PFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKP 1471
+PP QE W WS CS +CG G R + C+ G +++ C L +
Sbjct: 954 KPPTQELCHGNCVFTRWHYSEWSQCSRSCGG-GERSRESYCMNNFGHRLADNECQELSRV 1012
Query: 1472 LAGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKD 1531
E CN CP+ W S WS+C V+CG+G RQV C+ V +S C
Sbjct: 1013 TR--ENCNEFSCPS-WAASEWSECLVTCGKGTKQRQVWCQLN-----VDHLSDGFCNSST 1064
Query: 1532 RPLGRKPCFGHPCVQWE--PGNRCPGRCMGRAVRMQQRHTACQHNSS---DSNCDDRKRP 1586
+P PC H C W+ P C C G +M+ + S+ D+ C + RP
Sbjct: 1065 KPESLSPCELHTCASWQVGPWGPCTTTC-GHGYQMRDVKCVNELASAVLEDTECHEASRP 1123
Query: 1587 TLRRNCTSGACDVC------------------WHTGPWKPCTAACGRGFQSRKVDCIHTR 1628
+ R++C C W G W PC+ +CGRG Q+R V C
Sbjct: 1124 SDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDAL 1183
Query: 1629 SCKPVAKRHCVQKKKPISWRHCLGP 1653
+ + +C +P C P
Sbjct: 1184 D-RIADESYCAHLPRPAEIWDCFTP 1207
Score = 106 bits (264), Expect = 2e-22
Identities = 79/268 (29%), Positives = 106/268 (39%), Gaps = 33/268 (12%)
Query: 1428 WEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARW 1487
W G W CS++C G + + C NGQ S + CD KP + C CP +W
Sbjct: 1308 WRTGPWGSCSSSCSG-GLQHRAVVCQDENGQ--SASYCDAASKP-PELQQCGPGPCP-QW 1362
Query: 1488 FTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPC--- 1544
W +CS +CG G SR V C+ NG Q++ C ++P C H C
Sbjct: 1363 NYGNWGECSQTCGGGIKSRLVICQ--FPNG--QILEDHNCEIVNKPPSVIQCHMHACPAD 1418
Query: 1545 VQW--EPGNRCPGRC-MGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGACDVCW 1601
V W EP C C GR R Q D+NC ++P + C S C W
Sbjct: 1419 VSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCP-SW 1477
Query: 1602 HTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSCDRDCTD 1661
W C+ CG G Q R V C + V + C Q +P S R C C
Sbjct: 1478 KANSWNECSVTCGSGVQQRDVYC-RLKGVGQVVEEMCDQSTRPCSQRRCWSQDC------ 1530
Query: 1662 TTHYCMFVKHLNLCSLDRYKQRCCQSCQ 1689
V+H ++R + C SC+
Sbjct: 1531 -------VQHK---GMERGRLNCSTSCE 1548
Score = 105 bits (263), Expect = 3e-22
Identities = 80/277 (28%), Positives = 107/277 (38%), Gaps = 62/277 (22%)
Query: 1428 WEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPA-- 1485
W+ G+WS CSA+CGH + R M Q + E CD +PL E C++ CP
Sbjct: 1211 WQAGDWSPCSASCGH--GKTTRQVLCMNYHQPIDENYCDPEVRPLMEQE-CSLAACPPAH 1267
Query: 1486 ---------------------------------------RWFTSVWSQCSVSCGEGYHSR 1506
+W T W CS SC G R
Sbjct: 1268 SHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHR 1327
Query: 1507 QVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPCVQWEPGN--RCPGRCMGRAVRM 1564
V C+ NG S C +P + C PC QW GN C C G +
Sbjct: 1328 AVVCQ--DENGQ----SASYCDAASKPPELQQCGPGPCPQWNYGNWGECSQTCGGG---I 1378
Query: 1565 QQRHTACQHNSS----DSNCDDRKRPTLRRNCTSGAC--DVCWHTGPWKPCTAACGRGFQ 1618
+ R CQ + D NC+ +P C AC DV WH PW C+A+CG+G +
Sbjct: 1379 KSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRK 1438
Query: 1619 SRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSC 1655
R+V CI K + +C Q +KP + + C C
Sbjct: 1439 YREVFCIDQFQRK-LEDTNCSQVQKPPTHKACRSVRC 1474
Score = 104 bits (259), Expect = 8e-22
Identities = 69/254 (27%), Positives = 106/254 (41%), Gaps = 37/254 (14%)
Query: 1426 PFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPA 1485
P W WS C TCG G + ++ C + N +S+ C+ KP PC + C A
Sbjct: 1023 PSWAASEWSECLVTCGK-GTKQRQVWCQL-NVDHLSDGFCNSSTKP-ESLSPCELHTC-A 1078
Query: 1486 RWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPC- 1544
W W C+ +CG GY R V C A+ V+ C RP R+ C PC
Sbjct: 1079 SWQVGPWGPCTTTCGHGYQMRDVKCVNELASA---VLEDTECHEASRPSDRQSCVLTPCS 1135
Query: 1545 ------------------VQWEPGNRCP-GRCMGRAVRMQQRHTACQHN----SSDSNCD 1581
QW G+ P GR Q R+ +C+ + +S C
Sbjct: 1136 FISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGT--QARYVSCRDALDRIADESYCA 1193
Query: 1582 DRKRPTLRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQK 1641
RP +C + + W G W PC+A+CG G +R+V C++ +P+ + +C +
Sbjct: 1194 HLPRPAEIWDCFTPCGE--WQAGDWSPCSASCGHGKTTRQVLCMNYH--QPIDENYCDPE 1249
Query: 1642 KKPISWRHCLGPSC 1655
+P+ + C +C
Sbjct: 1250 VRPLMEQECSLAAC 1263
Score = 92.8 bits (229), Expect = 2e-18
Identities = 72/239 (30%), Positives = 98/239 (41%), Gaps = 23/239 (9%)
Query: 1428 WEPGNWSHCSATCGHLGARIQRPQCV---MANGQ--EVSEALC-DHLQKPLAGFEPCNIR 1481
W S CS+ CG G R C+ + GQ +V + C D L+ P E C+
Sbjct: 908 WHVIGKSECSSQCGQ-GYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQ--ELCHGN 964
Query: 1482 DCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFG 1541
RW S WSQCS SCG G SR+ C N ++ C R + R+ C
Sbjct: 965 CVFTRWHYSEWSQCSRSCGGGERSRESYCM----NNFGHRLADNECQELSR-VTRENCNE 1019
Query: 1542 HPCVQWEPG--NRCPGRCMGRAVRMQQRHTACQHNS---SDSNCDDRKRPTLRRNCTSGA 1596
C W + C C G+ + QR CQ N SD C+ +P C
Sbjct: 1020 FSCPSWAASEWSECLVTC-GKGTK--QRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHT 1076
Query: 1597 CDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSC 1655
C W GPW PCT CG G+Q R V C++ + + C + +P + C+ C
Sbjct: 1077 C-ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPC 1134
Score = 90.9 bits (224), Expect = 9e-18
Identities = 68/244 (27%), Positives = 102/244 (41%), Gaps = 30/244 (12%)
Query: 1400 HKKYILQATNTRTNSNDPTGEPPPQE--------PFWEPGNWSHCSATCGHLGARIQRPQ 1451
H+ + Q N ++ S PP+ P W GNW CS TCG G + +
Sbjct: 1326 HRAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNWGECSQTCGG-GIKSRLVI 1384
Query: 1452 CVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPA--RWFTSVWSQCSVSCGEGYHSRQVT 1509
C NGQ + + C+ + KP + + C++ CPA W W+ CS SCG+G R+V
Sbjct: 1385 CQFPNGQILEDHNCEIVNKPPSVIQ-CHMHACPADVSWHQEPWTSCSASCGKGRKYREVF 1443
Query: 1510 CKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPCVQWEPG--NRCPGRCMGRAVRMQQR 1567
C + + + C+ +P K C C W+ N C C G V QQR
Sbjct: 1444 C----IDQFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKANSWNECSVTC-GSGV--QQR 1496
Query: 1568 HTACQHNS----SDSNCDDRKRPTLRRNCTSGACDVCWHTGPWK---PCTAACGRGFQSR 1620
C+ + CD RP +R C S C H G + C+ +C R +
Sbjct: 1497 DVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDC--VQHKGMERGRLNCSTSCERKDSHQ 1554
Query: 1621 KVDC 1624
+++C
Sbjct: 1555 RMEC 1558
Score = 90.1 bits (222), Expect = 2e-17
Identities = 68/239 (28%), Positives = 100/239 (41%), Gaps = 22/239 (9%)
Query: 1428 WEP-GNWSHCSATCGHLGARIQRPQCVMANGQEV-SEALCDHLQKPLAGFEPCNIRDCPA 1485
W+P G W C+ C L R C+ + V S+ CDHL P + CN DC
Sbjct: 850 WDPYGPWEGCTKMCQGLQRR--NITCIHKSDHSVVSDKECDHLPLPSFVTQSCNT-DCEL 906
Query: 1486 RWFTSVWSQCSVSCGEGYHSRQVTC-KRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPC 1544
RW S+CS CG+GY + + C K + G V C + +P ++ C G+ C
Sbjct: 907 RWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGN-C 965
Query: 1545 V----QWEPGNRCPGRCMGRAVRMQQRHTACQ----HNSSDSNCDDRKRPTLRRNCTSGA 1596
V + ++C C G + R + C H +D+ C + R T R NC +
Sbjct: 966 VFTRWHYSEWSQCSRSCGGGE---RSRESYCMNNFGHRLADNECQELSRVT-RENCNEFS 1021
Query: 1597 CDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSC 1655
C W W C CG+G + R+V C + ++ C KP S C +C
Sbjct: 1022 CP-SWAASEWSECLVTCGKGTKQRQVWC--QLNVDHLSDGFCNSSTKPESLSPCELHTC 1077
Score = 89.4 bits (220), Expect = 3e-17
Identities = 68/270 (25%), Positives = 111/270 (41%), Gaps = 21/270 (7%)
Query: 1391 ESRIVFLQGHKKYILQATNTRTNSNDPTG-----EPPPQEPFWEPGNWSHCSATCGHLGA 1445
+SR+V Q IL+ N + P+ P + W W+ CSA+CG G
Sbjct: 1379 KSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGK-GR 1437
Query: 1446 RIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHS 1505
+ + C+ +++ + C +QKP + C CP+ W + W++CSV+CG G
Sbjct: 1438 KYREVFCIDQFQRKLEDTNCSQVQKPPT-HKACRSVRCPS-WKANSWNECSVTCGSGVQQ 1495
Query: 1506 RQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPCVQWEPGNR----CPGRCMGRA 1561
R V C + G QVV C RP ++ C+ CVQ + R C C +
Sbjct: 1496 RDVYC---RLKGVGQVVE-EMCDQSTRPCSQRRCWSQDCVQHKGMERGRLNCSTSCERKD 1551
Query: 1562 VRMQQRHTACQHNSSDSNCDDRKRPTL-RRNCTSGACDVCWHTGPWKPCTAACGRGFQSR 1620
+ T Q + + +L +NC + C+ T C CG ++ R
Sbjct: 1552 SHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTADSSQCANNCGFSYRQR 1611
Query: 1621 KVDCIHTRSCKPVAKRHCVQKKKPISWRHC 1650
C P K+H + + +PI ++ C
Sbjct: 1612 ITYCTEI----PSTKKHKLHRLRPIVYQEC 1637
Score = 76.3 bits (186), Expect = 2e-13
Identities = 78/350 (22%), Positives = 128/350 (36%), Gaps = 77/350 (22%)
Query: 329 SVVQFFFYQ-PISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENV 387
SV+Q + P W Q + C+ +CG G + C+D + +R + D C V
Sbjct: 1406 SVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCID-QFQRKLEDTNC----SQV 1460
Query: 388 KPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVE 447
+ P K C CPS W+ N W CSV+CG G+Q+R C
Sbjct: 1461 QKPPTHKACRSVRCPS------------------WKANSWNECSVTCGSGVQQRDVYCRL 1502
Query: 448 ESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPKWIAMEWSQ--CTVTCGRGLRYRVVLC 505
+ + QV E C + +P + C DC + ME + C+ +C R ++ + C
Sbjct: 1503 KG----VGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGMERGRLNCSTSCERKDSHQRMEC 1558
Query: 506 INHRGEHVGGC--NPQLKLHIKEECVIPIPC-----------------YKPKEKSPVEAK 546
+++ V N + C P PC + +++ +
Sbjct: 1559 TDNQIRQVNEIVYNSSTISLTSKNCRNP-PCNYIVVTADSSQCANNCGFSYRQRITYCTE 1617
Query: 547 LPWLKQAQELEETRIATEEPTFIPE-------------------PWSACSTTCGPGVQVR 587
+P K+ + I +E +P WS CS TCG G+ R
Sbjct: 1618 IPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKR 1677
Query: 588 EVKCRVLLTFTQTETELPEEECEGPKLP-TERPCLLEACDESPASRELDI 636
+VKC T+ L + C P ++ C C +E+ +
Sbjct: 1678 QVKC-------ITKHGLSSDLCLNHLKPGAQKKCYANDCKSFTTCKEIQV 1720
Score = 50.8 bits (120), Expect = 1e-05
Identities = 35/144 (24%), Positives = 52/144 (36%), Gaps = 29/144 (20%)
Query: 1549 PGNRCPGRCMGRAVRMQQRHTACQHNS-----SDSNCDDRKRPTLRRNCTSGACDVCWHT 1603
P C C G +Q+R+ C H S SD CD P+ + C++ WH
Sbjct: 855 PWEGCTKMCQG----LQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTDCELRWHV 910
Query: 1604 GPWKPCTAACGRGFQSRKVDC----IHTRSCKPVAKRHCVQKKKP------------ISW 1647
C++ CG+G+++ + C IH V +C + KP W
Sbjct: 911 IGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVFTRW 970
Query: 1648 RHCLGPSCDRDC----TDTTHYCM 1667
+ C R C YCM
Sbjct: 971 HYSEWSQCSRSCGGGERSRESYCM 994
Score = 41.2 bits (95), Expect = 0.009
Identities = 59/242 (24%), Positives = 78/242 (32%), Gaps = 53/242 (21%)
Query: 620 CLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEA--IAVCLHIQTQ 677
CLL+ DE + ++P Y G C G Q I +C+H+
Sbjct: 462 CLLDKPDEEIYNLPSELP---------GSRYDGNKQCELAFGPGSQMCPHINICMHLWCT 512
Query: 678 QTVN-DSLCDMVHRPPAMSQACN--------------TEPCPPRWHVGSWGP---CSATC 719
T C H PPA C TE P G W P CS TC
Sbjct: 513 STEKLHKGCFTQHVPPADGTDCGPGMHCRHGLCVNKETETRPVNGEWGPWEPYSSCSRTC 572
Query: 720 GVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQQCS------- 772
G GI++ C P E C + ++CN CP G +QCS
Sbjct: 573 GGGIESATRRCNRP-EPRNGGNYCVGRR-MKFRSCNTDSCPKGTQDFREKQCSDFNGKHL 630
Query: 773 -------------RTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPK--ASSHKSCART 817
R G GT++R Q+ F L D + G +H C +
Sbjct: 631 DISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVEDGTPCGTETHDICVQG 690
Query: 818 DC 819
C
Sbjct: 691 QC 692
Score = 40.4 bits (93), Expect = 0.015
Identities = 21/60 (35%), Positives = 28/60 (46%), Gaps = 6/60 (10%)
Query: 1485 ARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPC 1544
A W WS+CSV+CG G RQV C T +S C +P +K C+ + C
Sbjct: 1656 ATWKVGKWSKCSVTCGIGIMKRQVKCI------TKHGLSSDLCLNHLKPGAQKKCYANDC 1709
Score = 38.9 bits (89), Expect = 0.043
Identities = 26/78 (33%), Positives = 31/78 (39%), Gaps = 11/78 (14%)
Query: 60 YDDQTSRNTRSDEDKDGNWDAW--GDWSDCSRTCGGGASYSLRRC-------LTGRNCEG 110
Y D S+ + G W G+W +CS+TCGGG L C L NCE
Sbjct: 1341 YCDAASKPPELQQCGPGPCPQWNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCEI 1400
Query: 111 QNIRYKT--CSNHDCPPD 126
N C H CP D
Sbjct: 1401 VNKPPSVIQCHMHACPAD 1418
Score = 33.1 bits (74), Expect = 2.3
Identities = 21/76 (27%), Positives = 28/76 (36%), Gaps = 14/76 (18%)
Query: 82 GDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQCSAY--- 138
G WS CS TCG G +C+T C NH P + A C ++
Sbjct: 1661 GKWSKCSVTCGIGIMKRQVKCITKHGLSSD-----LCLNHLKPGAQKKCYANDCKSFTTC 1715
Query: 139 ------NDVQYQGHYY 148
N ++ G YY
Sbjct: 1716 KEIQVKNHIRKDGDYY 1731
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 295 bits (756), Expect = 2e-79
Identities = 244/914 (26%), Positives = 369/914 (40%), Gaps = 170/914 (18%)
Query: 75 DGNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPPDAE 128
DG+W +W + CSRTCGGG ++R C G+ C G+ +++K+C+ C
Sbjct: 588 DGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKR 647
Query: 129 DFRAQQCSAYNDVQYQGH----YYEWLPRYNDPAAP--CALKCHAQGQNLVVELAPKVLD 182
DFR +QC+ ++ + + W+P+Y+ C L C G +L +V+D
Sbjct: 648 DFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVID 707
Query: 183 GTRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEK 242
GT C D+ D+C+ G+C+ GCD L S A+ D CGVC GD S+C+ V G +
Sbjct: 708 GTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKTVAGTFNT---VHY 764
Query: 243 REENVIAVPLGSRSVRITVKGPAHLFIESK------TLQGSKGEHSFNSPGVFL------ 290
V+ +P G+ ++ + H F L SKGE N V
Sbjct: 765 GYNTVVRIPAGATNIDVR----QHSFSGETDDDNYLALSSSKGEFLLNGNFVVTMAKREI 820
Query: 291 -VENTTVEFQRGSE------RQTFKIPGPLMADFIF-------KTRYT---AAKDSVVQF 333
+ N VE+ GSE T +I L+ + RY+ +D QF
Sbjct: 821 RIGNAVVEYS-GSETAVERINSTDRIEQELLLQVLSVGKLYNPDVRYSFNIPIEDKPQQF 879
Query: 334 FFYQPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKL 393
++ SH Q PC G + C + V D C P+ P
Sbjct: 880 YWN---SHGPWQACSKPCQ-----GERKRKLVCTRESDQLTVSDQRCDRLPQ---PGHIT 928
Query: 394 KECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEES-MHG 452
+ C D C RW + CS CG G + C + S + G
Sbjct: 929 EPCGTD-CDL-----------------RWHVASRSECSAQCGLGYRTLDIYCAKYSRLDG 970
Query: 453 EILQVEEWKCMYAPKPKVMQTCNLFDCPK--WIAMEWSQCTVTCGRGLRYRVVLCINHRG 510
+ +V++ C PKP + C+ +C W W++C+ +C G + R +C+N R
Sbjct: 971 KTEKVDDGFCSSHPKPSNREKCS-GECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRN 1029
Query: 511 EHV--GGCNPQLKLHIKEECVIPIPCYKPKEKSPV--------EAKLPWLKQAQELEETR 560
+ + C Q K+ I+ P P +K + S + + W + ++ R
Sbjct: 1030 DVLDDSKCTHQEKVTIQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDR 1089
Query: 561 IATEE--PTFI-----PE-------PWSACSTTCGPGVQVREVKCRVLLTFTQTETELPE 606
+ E PT + PE PW CS TCG G Q+R VKC ++ T+ + +
Sbjct: 1090 MCDPETKPTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKC-IIGTYMSV---VDD 1145
Query: 607 EECEGPKLPTE-RPCLLEACDESPASRELDIPLPEDSETTY-----DWEYAGFTPCTATC 660
+C PT+ + C L +C PA+ PE +TY W + +TPC+ATC
Sbjct: 1146 NDCNAATRPTDTQDCELPSCHPPPAA-------PETRRSTYSAPRTQWRFGSWTPCSATC 1198
Query: 661 VGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCG 720
G + C + ++S C + RP A + C+ PC +W W CS TCG
Sbjct: 1199 GKGTRMRYVSC-RDENGSVADESACATLPRPVA-KEECSVTPC-GQWKALDWSSCSVTCG 1255
Query: 721 VGIQTRDVYCLHPGETPAPPEEC-RDEKPHALQACNQFDCPP------------------ 761
G TR V C++ + EC +D P Q C+ CP
Sbjct: 1256 QGRATRQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYR 1315
Query: 762 ---------------GWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGP 806
W W CS TC GG+Q R V C+ +G N + +
Sbjct: 1316 PRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQD--ENGYTAN---DCVERI 1370
Query: 807 KASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDL 866
K ++C C P A G+W +C+ CG GI+ R VCQR + G R P ++ C L
Sbjct: 1371 KPDEQRACESGPC-PQWAYGNWGECTKLCGGGIRTRLVVCQR--SNGERFP--DLSCEIL 1425
Query: 867 PGLPLVRSCQMPEC 880
P C C
Sbjct: 1426 DKPPDREQCNTHAC 1439
Score = 225 bits (574), Expect = 2e-58
Identities = 152/526 (28%), Positives = 228/526 (43%), Gaps = 64/526 (12%)
Query: 337 QPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPK-LKE 395
QP W+ + C+VTCG GYQL + +C+ VV D+ C N +P ++
Sbjct: 1105 QPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDC-----NAATRPTDTQD 1159
Query: 396 CSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEIL 455
C + C E + P +W WT CS +CG G + R C +E+ G +
Sbjct: 1160 CELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDEN--GSV- 1216
Query: 456 QVEEWKCMYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHV-- 513
+E C P+P + C++ C +W A++WS C+VTCG+G R V+C+N+ +HV
Sbjct: 1217 -ADESACATLPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNY-SDHVID 1274
Query: 514 -GGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFI--- 569
C+ ++C + PC +++P ++ L E R A+ T +
Sbjct: 1275 RSECDQDYIPETDQDCSMS-PC---PQRTP-DSGLAQHPFQNEDYRPRSASPSRTHVLGG 1329
Query: 570 ----PEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEAC 625
PW ACS+TC G Q R V C Q E +C P E+ AC
Sbjct: 1330 NQWRTGPWGACSSTCAGGSQRRVVVC-------QDENGYTANDCVERIKPDEQ----RAC 1378
Query: 626 DESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLC 685
+ P + W Y + CT C GG + + VC + D C
Sbjct: 1379 ESGPCPQ---------------WAYGNWGECTKLCGGGIRTRLVVCQR-SNGERFPDLSC 1422
Query: 686 DMVHRPPAMSQACNTEPCP--PRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEEC 743
+++ +PP Q CNT CP W G W CS +CG G + R+VYC+ + + C
Sbjct: 1423 EILDKPPDREQ-CNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYC 1481
Query: 744 RD-EKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDEL 802
+ KPH + C CP W W QCS +CG G Q R V C+ G+ +
Sbjct: 1482 KHLAKPHGHRKCRGGRCPK-WKAGAWSQCSVSCGRGVQQRHVGCQ----IGTHKIARETE 1536
Query: 803 CQG-PKASSHKSCARTDCPPHL-AVGDWSKCSVSCGVGIQRRKQVC 846
C + S + C CP + +W +C+ +CG G + RK VC
Sbjct: 1537 CNPYTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVC 1582
Score = 213 bits (541), Expect = 2e-54
Identities = 172/602 (28%), Positives = 239/602 (39%), Gaps = 112/602 (18%)
Query: 343 WRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCP 402
WR + + C+ +C GG Q A CV+ R V+ D C + + K ++ CS PCP
Sbjct: 1001 WRYSAWTECSKSCDGGTQRRRAICVNTR-NDVLDDSKCTH-----QEKVTIQRCSEFPCP 1054
Query: 403 SSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKC 462
+W+ W+ C V+CG G + R C GE ++ + C
Sbjct: 1055 ------------------QWKSGDWSECLVTCGKGHKHRQVWC----QFGED-RLNDRMC 1091
Query: 463 MYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHV---GGCNPQ 519
KP MQTC +C W A W QC+VTCG+G + R V CI V CN
Sbjct: 1092 DPETKPTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAA 1151
Query: 520 LKLHIKEECVIPIPCYKP------KEKSPVEAKLPWL----------------------- 550
+ ++C +P C+ P + + + W
Sbjct: 1152 TRPTDTQDCELP-SCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCR 1210
Query: 551 -KQAQELEETRIAT-------EEPTFIP------EPWSACSTTCGPGVQVREVKCRVLLT 596
+ +E+ AT EE + P WS+CS TCG G R+V C
Sbjct: 1211 DENGSVADESACATLPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQVMC----- 1265
Query: 597 FTQTETELPEEECEGPKLP-TERPCLLEACD---------ESPASRELDIPLPEDSETTY 646
++ + EC+ +P T++ C + C + P E P T+
Sbjct: 1266 VNYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTH 1325
Query: 647 -----DWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTE 701
W + C++TC GG Q + VC + T ND + P +AC +
Sbjct: 1326 VLGGNQWRTGPWGACSSTCAGGSQRRVVVC-QDENGYTANDC---VERIKPDEQRACESG 1381
Query: 702 PCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRD-EKPHALQACNQFDCP 760
PC P+W G+WG C+ CG GI+TR V C P C +KP + CN CP
Sbjct: 1382 PC-PQWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACP 1440
Query: 761 --PGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTD 818
W W CS +CG G + R V C + DGS L SD K H+ C
Sbjct: 1441 HDAAWSTGPWSSCSVSCGRGHKQRNVYC--MAKDGSHLE-SDYCKHLAKPHGHRKCRGGR 1497
Query: 819 CPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQMP 878
CP A G WS+CSVSCG G+Q+R CQ K R E C R CQ P
Sbjct: 1498 CPKWKA-GAWSQCSVSCGRGVQQRHVGCQIGTHKIAR----ETECNPYTRPESERDCQGP 1552
Query: 879 EC 880
C
Sbjct: 1553 RC 1554
Score = 202 bits (514), Expect = 2e-51
Identities = 151/570 (26%), Positives = 228/570 (40%), Gaps = 94/570 (16%)
Query: 342 QWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCH--YYPENVKPKPKLKECSMD 399
QW+ D+ C+VTCG G CV+ V+ C Y PE + +CSM
Sbjct: 1241 QWKALDWSSCSVTCGQGRATRQVMCVNYS-DHVIDRSECDQDYIPETDQ------DCSMS 1293
Query: 400 PCP--SSDGFKEIMPYDHFQPLPR--------------WEHNPWTACSVSCGGGIQRRSF 443
PCP + D P+ + PR W PW ACS +C GG QRR
Sbjct: 1294 PCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVV 1353
Query: 444 VCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVV 503
VC +E+ + C+ KP + C CP+W W +CT CG G+R R+V
Sbjct: 1354 VCQDENGYTAN------DCVERIKPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLV 1407
Query: 504 LCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIAT 563
+C GE P L I + KP ++ E T
Sbjct: 1408 VCQRSNGERF----PDLSCEILD---------KPPDR--------------EQCNTHACP 1440
Query: 564 EEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPT-ERPCLL 622
+ + PWS+CS +CG G + R V C + + L + C+ P R C
Sbjct: 1441 HDAAWSTGPWSSCSVSCGRGHKQRNVYC-----MAKDGSHLESDYCKHLAKPHGHRKCRG 1495
Query: 623 EACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVND 682
C + W+ ++ C+ +C G Q+ C I T + +
Sbjct: 1496 GRCPK--------------------WKAGAWSQCSVSCGRGVQQRHVGC-QIGTHKIARE 1534
Query: 683 SLCDMVHRPPAMSQACNTEPCPP-RWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPE 741
+ C+ RP + + C CP W W C+ TCG G + R V C+ +
Sbjct: 1535 TECNPYTRPES-ERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGA 1593
Query: 742 ECR-DEKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSD 800
C ++P ++C+ C W EW +CS TCG G + R V+C ++ T S
Sbjct: 1594 RCDVSKRPVDRESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSY 1653
Query: 801 EL---CQGPKASSHKSCARTDCPPHLA--VGDWSKCSVSCGVGIQRRKQVCQRLAAKGRR 855
+ C G + S C DCP VG+W CSVSCGVG+ +R C +
Sbjct: 1654 QTTINCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSH 1713
Query: 856 IPLSEMMCRDLPGLPLVRSCQMPE-CSKIK 884
+ +++ + V +C++P+ C ++K
Sbjct: 1714 LCHTDLKPEERKTCRNVYNCELPQNCKEVK 1743
Score = 133 bits (334), Expect = 2e-30
Identities = 78/253 (30%), Positives = 119/253 (47%), Gaps = 18/253 (7%)
Query: 635 DIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAM 694
+IP+ + + Y + + C+ C G + + VC Q TV+D CD + +P +
Sbjct: 869 NIPIEDKPQQFYWNSHGPWQACSKPCQGERKRKL-VCTRESDQLTVSDQRCDRLPQPGHI 927
Query: 695 SQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRD------EKP 748
++ C T+ C RWHV S CSA CG+G +T D+YC E+ D KP
Sbjct: 928 TEPCGTD-CDLRWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKP 986
Query: 749 HALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKA 808
+ C+ GW W +CS++C GGTQ RR C D L D C +
Sbjct: 987 SNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRND----VLDDSKCTHQEK 1042
Query: 809 SSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPG 868
+ + C+ CP + GDWS+C V+CG G + R+ CQ + L++ MC
Sbjct: 1043 VTIQRCSEFPCPQWKS-GDWSECLVTCGKGHKHRQVWCQFGEDR-----LNDRMCDPETK 1096
Query: 869 LPLVRSCQMPECS 881
+++CQ PEC+
Sbjct: 1097 PTSMQTCQQPECA 1109
Score = 132 bits (331), Expect = 4e-30
Identities = 94/312 (30%), Positives = 127/312 (40%), Gaps = 31/312 (9%)
Query: 1391 ESRIVFLQGHKKYILQATNTRTNSNDPTGEPPPQEPFWEPGNWSHCSATCGHLGARIQRP 1450
+ R+V Q Y R ++ P W GNW C+ CG G R +
Sbjct: 1349 QRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWAYGNWGECTKLCGG-GIRTRLV 1407
Query: 1451 QCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCP--ARWFTSVWSQCSVSCGEGYHSRQV 1508
C +NG+ + C+ L KP E CN CP A W T WS CSVSCG G+ R V
Sbjct: 1408 VCQRSNGERFPDLSCEILDKP-PDREQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNV 1466
Query: 1509 TCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPCVQWEPG--NRCPGRCMGRAVRMQQ 1566
C + + C +P G + C G C +W+ G ++C C GR V QQ
Sbjct: 1467 YCMAKDGSH----LESDYCKHLAKPHGHRKCRGGRCPKWKAGAWSQCSVSC-GRGV--QQ 1519
Query: 1567 RHTACQHN----SSDSNCDDRKRPTLRRNCTSGACDV-CWHTGPWKPCTAACGRGFQSRK 1621
RH CQ + ++ C+ RP R+C C + W W+ CT CG G + RK
Sbjct: 1520 RHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRK 1579
Query: 1622 VDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSCDRDCTDTTHYCMFVKHLNLCSL---D 1678
V C+ V C K+P+ C C+ Y + CS+
Sbjct: 1580 VVCVDDNK-NEVHGARCDVSKRPVDRESCSLQPCE--------YVWITGEWSECSVTCGK 1630
Query: 1679 RYKQRCCQSCQE 1690
YKQR SC E
Sbjct: 1631 GYKQRLV-SCSE 1641
Score = 126 bits (316), Expect = 2e-28
Identities = 80/264 (30%), Positives = 109/264 (41%), Gaps = 37/264 (14%)
Query: 1423 PQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRD 1482
P + W G WS CS +CG G + + C+ +G + C HL KP G C
Sbjct: 1440 PHDAAWSTGPWSSCSVSCGR-GHKQRNVYCMAKDGSHLESDYCKHLAKP-HGHRKCRGGR 1497
Query: 1483 CPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGH 1542
CP +W WSQCSVSCG G R V C+ GT ++ C P RP + C G
Sbjct: 1498 CP-KWKAGAWSQCSVSCGRGVQQRHVGCQI----GTHKIARETECNPYTRPESERDCQGP 1552
Query: 1543 PCVQW----EPGNRCPGRCMGRAVRMQQRHTACQHNSSD----SNCDDRKRPTLRRNCTS 1594
C + E C C G R R C ++ + + CD KRP R +C+
Sbjct: 1553 RCPLYTWRAEEWQECTKTC-GEGSRY--RKVVCVDDNKNEVHGARCDVSKRPVDRESCSL 1609
Query: 1595 GACDVCWHTGPWKPCTAACGRGFQSRKVDC-----------------IHTRSCKPVAKRH 1637
C+ W TG W C+ CG+G++ R V C I+ +P +
Sbjct: 1610 QPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHP 1669
Query: 1638 CVQKKKPIS--WRHCLGPSCDRDC 1659
C + P+S WR SC C
Sbjct: 1670 CYLRDCPVSATWRVGNWGSCSVSC 1693
Score = 107 bits (266), Expect = 1e-22
Identities = 73/246 (29%), Positives = 109/246 (44%), Gaps = 20/246 (8%)
Query: 1420 EPPPQEPFWEP-GNWSHCSATCGHLGARIQRPQCVMANGQ-EVSEALCDHLQKPLAGFEP 1477
E PQ+ +W G W CS C G R ++ C + Q VS+ CD L +P EP
Sbjct: 873 EDKPQQFYWNSHGPWQACSKPCQ--GERKRKLVCTRESDQLTVSDQRCDRLPQPGHITEP 930
Query: 1478 CNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTC-KRTKANGTVQVVSPRACAPKDRPLGR 1536
C DC RW + S+CS CG GY + + C K ++ +G + V C+ +P R
Sbjct: 931 CGT-DCDLRWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNR 989
Query: 1537 KPCFGHPCV---QWEPGNRCPGRCMGRAVRMQQRHTACQHNSS----DSNCDDRKRPTLR 1589
+ C G ++ C C G Q+R C + + DS C +++ T++
Sbjct: 990 EKCSGECNTGGWRYSAWTECSKSCDGGT---QRRRAICVNTRNDVLDDSKCTHQEKVTIQ 1046
Query: 1590 RNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRH 1649
R C+ C W +G W C CG+G + R+V C + R C + KP S +
Sbjct: 1047 R-CSEFPCPQ-WKSGDWSECLVTCGKGHKHRQVWCQFGED--RLNDRMCDPETKPTSMQT 1102
Query: 1650 CLGPSC 1655
C P C
Sbjct: 1103 CQQPEC 1108
Score = 107 bits (266), Expect = 1e-22
Identities = 91/318 (28%), Positives = 122/318 (38%), Gaps = 78/318 (24%)
Query: 1417 PTGEPPPQEPF------------WEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEAL 1464
P+ PPP P W G+W+ CSATCG G R++ C NG E+
Sbjct: 1163 PSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGK-GTRMRYVSCRDENGSVADESA 1221
Query: 1465 CDHLQKPLAGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSP 1524
C L +P+A E C++ C +W WS CSV+CG+G +RQV C N + V+
Sbjct: 1222 CATLPRPVAK-EECSVTPC-GQWKALDWSSCSVTCGQGRATRQVMC----VNYSDHVIDR 1275
Query: 1525 RACAPKDRPLGRKPCFGHPCVQWEP----------------------------GNR---- 1552
C P + C PC Q P GN+
Sbjct: 1276 SECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTG 1335
Query: 1553 ----CPGRCMGRAVRMQQRHTACQHNS--SDSNCDDRKRPTLRRNCTSGACDVCWHTGPW 1606
C C G + Q+R CQ + + ++C +R +P +R C SG C W G W
Sbjct: 1336 PWGACSSTCAGGS---QRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQ-WAYGNW 1391
Query: 1607 KPCTAACGRGFQSRKVDCIHTR-------SC----KPVAKRHCVQKKKPISWRHCLGP-- 1653
CT CG G ++R V C + SC KP + C P GP
Sbjct: 1392 GECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACPHDAAWSTGPWS 1451
Query: 1654 ----SCDRDCTDTTHYCM 1667
SC R YCM
Sbjct: 1452 SCSVSCGRGHKQRNVYCM 1469
Score = 99.8 bits (247), Expect = 2e-20
Identities = 69/238 (28%), Positives = 98/238 (41%), Gaps = 21/238 (8%)
Query: 1428 WEPGNWSHCSATCGHLGARIQRPQCVM-----ANGQEVSEALCDHLQKPLAGFEPCNIRD 1482
W + S CSA CG LG R C ++V + C KP + E C+
Sbjct: 939 WHVASRSECSAQCG-LGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKP-SNREKCSGEC 996
Query: 1483 CPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGH 1542
W S W++CS SC G R+ C T+ + V+ C +++ ++ C
Sbjct: 997 NTGGWRYSAWTECSKSCDGGTQRRRAICVNTRND----VLDDSKCTHQEKVTIQR-CSEF 1051
Query: 1543 PCVQWEPGN--RCPGRCMGRAVRMQQRHTACQHNS---SDSNCDDRKRPTLRRNCTSGAC 1597
PC QW+ G+ C C G+ + R CQ +D CD +PT + C C
Sbjct: 1052 PCPQWKSGDWSECLVTC-GKGHK--HRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPEC 1108
Query: 1598 DVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSC 1655
W GPW C+ CG+G+Q R V CI V C +P + C PSC
Sbjct: 1109 -ASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSC 1165
Score = 97.8 bits (242), Expect = 8e-20
Identities = 68/262 (25%), Positives = 107/262 (40%), Gaps = 51/262 (19%)
Query: 1428 WEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARW 1487
W W+ CS +C G + +R CV + ++ C H +K + C+ CP +W
Sbjct: 1001 WRYSAWTECSKSCDG-GTQRRRAICVNTRNDVLDDSKCTHQEK--VTIQRCSEFPCP-QW 1056
Query: 1488 FTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPCVQW 1547
+ WS+C V+CG+G+ RQV C+ + ++ R C P+ +P + C C W
Sbjct: 1057 KSGDWSECLVTCGKGHKHRQVWCQFGEDR-----LNDRMCDPETKPTSMQTCQQPECASW 1111
Query: 1548 EPG--NRCPGRCMGRAVRMQQRHTACQHNS-----SDSNCDDRKRPTLRRNCTSGACD-- 1598
+ G +C C Q R C + D++C+ RPT ++C +C
Sbjct: 1112 QAGPWGQCSVTC---GQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPP 1168
Query: 1599 ---------------VCWHTGPWKPCTAACGRGFQSRKVDC-------IHTRSC----KP 1632
W G W PC+A CG+G + R V C +C +P
Sbjct: 1169 PAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRP 1228
Query: 1633 VAKRHC----VQKKKPISWRHC 1650
VAK C + K + W C
Sbjct: 1229 VAKEECSVTPCGQWKALDWSSC 1250
Score = 97.4 bits (241), Expect = 1e-19
Identities = 75/238 (31%), Positives = 100/238 (42%), Gaps = 25/238 (10%)
Query: 1428 WEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARW 1487
W G W CS+TC G++ + C NG ++ C KP C CP +W
Sbjct: 1332 WRTGPWGACSSTCAG-GSQRRVVVCQDENGYTAND--CVERIKPDEQ-RACESGPCP-QW 1386
Query: 1488 FTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPC--- 1544
W +C+ CG G +R V C+R +NG + +C D+P R+ C H C
Sbjct: 1387 AYGNWGECTKLCGGGIRTRLVVCQR--SNG--ERFPDLSCEILDKPPDREQCNTHACPHD 1442
Query: 1545 VQWE--PGNRCPGRCMGRAVRMQQRHTAC-----QHNSSDSNCDDRKRPTLRRNCTSGAC 1597
W P + C C GR +QR+ C H SD C +P R C G C
Sbjct: 1443 AAWSTGPWSSCSVSC-GRG--HKQRNVYCMAKDGSHLESD-YCKHLAKPHGHRKCRGGRC 1498
Query: 1598 DVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSC 1655
W G W C+ +CGRG Q R V C + K + C +P S R C GP C
Sbjct: 1499 PK-WKAGAWSQCSVSCGRGVQQRHVGC-QIGTHKIARETECNPYTRPESERDCQGPRC 1554
Score = 96.3 bits (238), Expect = 2e-19
Identities = 84/332 (25%), Positives = 121/332 (36%), Gaps = 74/332 (22%)
Query: 1389 WPESRIVFLQGHK--KYILQATNTRTNSN--DPTGEPP-------PQEPFWEPGNWSHCS 1437
W E + +GHK + Q R N DP +P P+ W+ G W CS
Sbjct: 1061 WSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPECASWQAGPWGQCS 1120
Query: 1438 ATCGHLGARIQRPQCVMANGQE-VSEALCDHLQKPLAGFEPCNIRDC---PA-------- 1485
TCG G +++ +C++ V + C+ +P + C + C PA
Sbjct: 1121 VTCGQ-GYQLRAVKCIIGTYMSVVDDNDCNAATRP-TDTQDCELPSCHPPPAAPETRRST 1178
Query: 1486 ------RWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPC 1539
+W W+ CS +CG+G R V+C+ NG+ V ACA RP+ ++ C
Sbjct: 1179 YSAPRTQWRFGSWTPCSATCGKGTRMRYVSCR--DENGS--VADESACATLPRPVAKEEC 1234
Query: 1540 FGHPCVQWE--PGNRCPGRC-MGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGA 1596
PC QW+ + C C GRA R H S CD P ++C+
Sbjct: 1235 SVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSP 1294
Query: 1597 CDV---------------------------------CWHTGPWKPCTAACGRGFQSRKVD 1623
C W TGPW C++ C G Q R V
Sbjct: 1295 CPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVV 1354
Query: 1624 CIHTRSCKPVAKRHCVQKKKPISWRHCLGPSC 1655
C + CV++ KP R C C
Sbjct: 1355 C---QDENGYTANDCVERIKPDEQRACESGPC 1383
Score = 69.3 bits (168), Expect = 3e-11
Identities = 92/411 (22%), Positives = 145/411 (35%), Gaps = 75/411 (18%)
Query: 80 AWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQCSAYN 139
A+G+W +C++ CGGG L C + G+ +C D PPD E C
Sbjct: 1387 AYGNWGECTKLCGGGIRTRLVVC---QRSNGERFPDLSCEILDKPPDREQCNTHACP--- 1440
Query: 140 DVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLDGTRCNTDSLDMCISGI- 198
H W P + C++ C + V K DG+ +D
Sbjct: 1441 ------HDAAWS---TGPWSSCSVSCGRGHKQRNVYCMAK--DGSHLESDYCKHLAKPHG 1489
Query: 199 ---CQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKREENVIAVPLGSR 255
C+ C + + C V G G R V Q +H + E N P R
Sbjct: 1490 HRKCRGGRCPKWKAGAWSQ--CSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESER 1547
Query: 256 SVRITVKGPAHLFIESKTLQGSK--GEHSFNSPGVFLVENTTVEFQRGSERQTFKIPGPL 313
+ + P + + + + +K GE S V + +N G+ K P
Sbjct: 1548 DCQ-GPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEV--HGARCDVSKRP--- 1601
Query: 314 MADFIFKTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKR 373
++S QP + W ++ C+VTCG GY+ C +I +
Sbjct: 1602 -----------VDRESCS----LQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGK 1646
Query: 374 VVPDHYCHYYPENVK----PKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTA 429
++Y + Y + P + C + CP S W W +
Sbjct: 1647 ---ENYEYSYQTTINCPGTQPPSVHPCYLRDCPVS---------------ATWRVGNWGS 1688
Query: 430 CSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTC-NLFDC 479
CSVSCG G+ +RS C+ L C KP+ +TC N+++C
Sbjct: 1689 CSVSCGVGVMQRSVQCLTNEDQPSHL------CHTDLKPEERKTCRNVYNC 1733
Score = 59.7 bits (143), Expect = 2e-08
Identities = 38/97 (39%), Positives = 43/97 (44%), Gaps = 12/97 (12%)
Query: 1423 PQEPFWEPGNWSHCSATCGHLGARIQRPQCV-MANGQEVSEAL------CDHLQKPLAGF 1475
P E W G WS CS TCG G + + C + G+E E C Q P
Sbjct: 1611 PCEYVWITGEWSECSVTCGK-GYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPP--SV 1667
Query: 1476 EPCNIRDCP--ARWFTSVWSQCSVSCGEGYHSRQVTC 1510
PC +RDCP A W W CSVSCG G R V C
Sbjct: 1668 HPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQC 1704
Score = 42.7 bits (99), Expect = 0.003
Identities = 31/136 (22%), Positives = 45/136 (33%), Gaps = 25/136 (18%)
Query: 1549 PGNRCPGRCMGRAVRMQQRHTACQHNS-----SDSNCDDRKRPTLRRNCTSGACDVCWHT 1603
P C C G ++R C S SD CD +P CD+ WH
Sbjct: 886 PWQACSKPCQGE----RKRKLVCTRESDQLTVSDQRCDRLPQPGHITEPCGTDCDLRWHV 941
Query: 1604 GPWKPCTAACGRGFQSRKVDC------------IHTRSC----KPVAKRHCVQKKKPISW 1647
C+A CG G+++ + C + C KP + C + W
Sbjct: 942 ASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGW 1001
Query: 1648 RHCLGPSCDRDCTDTT 1663
R+ C + C T
Sbjct: 1002 RYSAWTECSKSCDGGT 1017
Score = 35.4 bits (80), Expect = 0.47
Identities = 20/69 (28%), Positives = 30/69 (43%), Gaps = 9/69 (13%)
Query: 64 TSRNTRSDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRN-------CEGQ-NIRY 115
++R S E G W + W++CS++C GG C+ RN C Q +
Sbjct: 987 SNREKCSGECNTGGW-RYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTI 1045
Query: 116 KTCSNHDCP 124
+ CS CP
Sbjct: 1046 QRCSEFPCP 1054
Score = 32.7 bits (73), Expect = 3.1
Identities = 26/94 (27%), Positives = 38/94 (40%), Gaps = 14/94 (14%)
Query: 52 GEQFLTYRYDDQTSRN--TRSDEDKDGN--------WDAWGDWSDCSRTCGGGASYSLRR 101
G Q T++ +T N TR + ++D W A +W +C++TCG G+ Y
Sbjct: 1523 GCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTWRA-EEWQECTKTCGEGSRYRKVV 1581
Query: 102 CLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQC 135
C+ E R C P D E Q C
Sbjct: 1582 CVDDNKNEVHGAR---CDVSKRPVDRESCSLQPC 1612
Score = 31.6 bits (70), Expect = 6.8
Identities = 23/73 (31%), Positives = 36/73 (49%), Gaps = 11/73 (15%)
Query: 632 RELDIPLPEDSETTYDW-EYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHR 690
+E+D+P+ + S W ++ F C+ TC GG + AI C + + C V R
Sbjct: 580 KEMDVPVTDGS-----WGSWSPFGTCSRTCGGGIKTAIRECNRPEPKN--GGKYC--VGR 630
Query: 691 PPAMSQACNTEPC 703
++CNTEPC
Sbjct: 631 RMKF-KSCNTEPC 642
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 286 bits (732), Expect = 1e-76
Identities = 199/665 (29%), Positives = 284/665 (42%), Gaps = 112/665 (16%)
Query: 76 GNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPPDAED 129
G W AW WS+CSRTCGGG + R C G C G + Y+ C+ + C ++ D
Sbjct: 590 GQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLD 649
Query: 130 FRAQQCSAYNDVQYQGHYYEWLPRYN-DPAAPCALKCHAQGQNLVVELAPKVLDGTRCNT 188
FRAQQC+ YN ++G +Y+W P + C L C A+ ++ KV DGT C+
Sbjct: 650 FRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSP 709
Query: 189 DSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKREE--N 246
+ D+CI G+C+ VGCD +LGS A D CGVC GD STC+ +G +++ K E
Sbjct: 710 NKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKG---LYLNQHKANEYYP 766
Query: 247 VIAVPLGSRSVRITVKGPAHLFIESKTLQGS---KGEHSFNSPGVFLVENTTVEFQRGSE 303
V+ +P G+RS+ I + ++ ++L G S + PG F TT E+QR
Sbjct: 767 VVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFN 826
Query: 304 R-QTFKIPGPLMADFIFKTRYTAAKDSVVQFFFYQPI-----------SHQWRQTDFFPC 351
R + PGP +F+ + + + ++ W C
Sbjct: 827 RPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQ-SEC 885
Query: 352 TVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIM 411
+V+CGGGY A C+ + V +C KP + K C+ CP+
Sbjct: 886 SVSCGGGYINVKAICLRDQ-NTQVNSSFC---SAKTKPVTEPKICNAFSCPA-------- 933
Query: 412 PYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVM 471
W W+ CS +C GG Q R CV++ + V C + P +
Sbjct: 934 ---------YWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVS-TPTQV 983
Query: 472 QTCNLFDC-PKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHV--GGCNPQLKLHIKEEC 528
Q CN C P+W WSQC+ TCGRG+R R +LC E + C + ++E C
Sbjct: 984 QACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGC 1043
Query: 529 VIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVRE 588
V+ + P ++L W + WS CS TCG GV+ RE
Sbjct: 1044 VL--------GRCPKNSRLQW-------------------VASSWSECSATCGLGVRKRE 1076
Query: 589 VKCR------VLLTFTQTETELPEEECEG---PKLPTERPCLLEACDESPASRELDIPLP 639
+KC L+TF PE C P L E C AC P
Sbjct: 1077 MKCSEKGFQGKLITF-------PERRCRNIKKPNLDLEETCNRRACPAHPV--------- 1120
Query: 640 EDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACN 699
W + CT TC GG Q C+ QQ S C ++H+ P + +ACN
Sbjct: 1121 --YNMVAGWYSLPWQQCTVTCGGGVQTRSVHCV----QQGRPSSSC-LLHQKPPVLRACN 1173
Query: 700 TEPCP 704
T CP
Sbjct: 1174 TNFCP 1178
Score = 133 bits (335), Expect = 1e-30
Identities = 93/343 (27%), Positives = 138/343 (40%), Gaps = 59/343 (17%)
Query: 562 ATEEPTFIPEPWSA----CSTTCGPG-VQVREVKCRVLLTFTQTETELPEEECEGPKLPT 616
AT+ P + WS CS +CG G + V+ + R T++ C P
Sbjct: 870 ATKRPAYT---WSIVQSECSVSCGGGYINVKAICLR------DQNTQVNSSFCSAKTKPV 920
Query: 617 ERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLH--- 673
P + A PA W ++ C+ C GG Q C+
Sbjct: 921 TEPKICNAFS-CPAY----------------WMPGEWSTCSKACAGGQQSRKIQCVQKKP 963
Query: 674 IQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHP 733
Q ++ V SLC + P QACN+ CPP+W +G W CS TCG G++ R++ C
Sbjct: 964 FQKEEAVLHSLCPV--STPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGS 1021
Query: 734 GETPAPPEECRD-EKPHALQACNQFDCPPG----WHIEEWQQCSRTCGGGTQNRRVTCRQ 788
P +C +P + C CP W W +CS TCG G + R + C +
Sbjct: 1022 AAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSE 1081
Query: 789 LLTDGSFLNLSDELCQG---PKASSHKSCARTDCPPH----LAVG----DWSKCSVSCGV 837
G + + C+ P ++C R CP H + G W +C+V+CG
Sbjct: 1082 KGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGG 1141
Query: 838 GIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQMPEC 880
G+Q R C +GR P S + P P++R+C C
Sbjct: 1142 GVQTRSVHC---VQQGR--PSSSCLLHQKP--PVLRACNTNFC 1177
Score = 125 bits (314), Expect = 3e-28
Identities = 100/347 (28%), Positives = 142/347 (40%), Gaps = 69/347 (19%)
Query: 430 CSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVM-QTCNLFDCPK-WIAMEW 487
CSVSCGGG +C+ + + QV C KP + CN F CP W+ EW
Sbjct: 885 CSVSCGGGYINVKAICLRD----QNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEW 940
Query: 488 SQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKL 547
S C+ C G + R + C+ Q K KEE V+ C PV
Sbjct: 941 STCSKACAGGQQSRKIQCV------------QKKPFQKEEAVLHSLC-------PVSTPT 981
Query: 548 PWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEE 607
+++ P + PWS CS TCG GV+ RE+ C+ T LPE
Sbjct: 982 -------QVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAET-----LPES 1029
Query: 608 ECEG-PKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQE 666
+C P+ + C+L C P++S W + ++ C+ATC G ++
Sbjct: 1030 QCTSLPRPELQEGCVLGRC-------------PKNSRL--QWVASSWSECSATCGLGVRK 1074
Query: 667 AIAVCLHIQTQQ---TVNDSLCDMVHRPPA-MSQACNTEPCPPR--------WHVGSWGP 714
C Q T + C + +P + + CN CP W+ W
Sbjct: 1075 REMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQ 1134
Query: 715 CSATCGVGIQTRDVYCLHPGETPAPPEECR-DEKPHALQACNQFDCP 760
C+ TCG G+QTR V+C+ G P C +KP L+ACN CP
Sbjct: 1135 CTVTCGGGVQTRSVHCVQQGR---PSSSCLLHQKPPVLRACNTNFCP 1178
Score = 120 bits (300), Expect = 1e-26
Identities = 93/334 (27%), Positives = 139/334 (41%), Gaps = 59/334 (17%)
Query: 1401 KKYILQATNTRTNSNDPTGEPPP-QEP----------FWEPGNWSHCSATCGHLGARIQR 1449
K L+ NT+ NS+ + + P EP +W PG WS CS C G + ++
Sbjct: 897 KAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAG-GQQSRK 955
Query: 1450 PQCVMANGQEVSEALCDHLQKPLAG---FEPCNIRDCPARWFTSVWSQCSVSCGEGYHSR 1506
QCV + EA+ H P++ + CN CP +W WSQCS +CG G R
Sbjct: 956 IQCVQKKPFQKEEAVL-HSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKR 1014
Query: 1507 QVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPC-----VQWEPGN--RCPGRCMG 1559
++ CK + A + + C RP ++ C C +QW + C C G
Sbjct: 1015 ELLCKGSAA----ETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATC-G 1069
Query: 1560 RAVRMQQRHTACQHNS--------SDSNCDDRKRPTL--RRNCTSGACDVC--------W 1601
VR +R C + C + K+P L C AC W
Sbjct: 1070 LGVR--KREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGW 1127
Query: 1602 HTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSC------ 1655
++ PW+ CT CG G Q+R V C+ + +P + C+ +KP R C C
Sbjct: 1128 YSLPWQQCTVTCGGGVQTRSVHCV--QQGRPSSS--CLLHQKPPVLRACNTNFCPAPEKR 1183
Query: 1656 -DRDCTDTTHYCMFVKHLNLCSLDRYKQRCCQSC 1688
D C D ++C V +C+ Y ++CC+SC
Sbjct: 1184 EDPSCVDFFNWCHLVPQHGVCNHKFYGKQCCKSC 1217
Score = 99.8 bits (247), Expect = 2e-20
Identities = 53/170 (31%), Positives = 76/170 (44%), Gaps = 6/170 (3%)
Query: 715 CSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQA--CNQFDCPPGWHIEEWQQCS 772
CS +CG G CL T C + + CN F CP W EW CS
Sbjct: 885 CSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCS 944
Query: 773 RTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCS 832
+ C GG Q+R++ C Q + LC + ++C CPP ++G WS+CS
Sbjct: 945 KACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCS 1004
Query: 833 VSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQMPECSK 882
+CG G+++R+ +C+ AA+ L E C LP L C + C K
Sbjct: 1005 KTCGRGVRKRELLCKGSAAE----TLPESQCTSLPRPELQEGCVLGRCPK 1050
Score = 73.9 bits (180), Expect = 1e-12
Identities = 54/199 (27%), Positives = 84/199 (42%), Gaps = 15/199 (7%)
Query: 1468 LQKPLAGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRAC 1527
L K + G P R PA ++ V S+CSVSCG GY + + C R + V+ C
Sbjct: 860 LPKVMNGTPPATKR--PAYTWSIVQSECSVSCGGGYINVKAICLRDQNT----QVNSSFC 913
Query: 1528 APKDRPLGR-KPCFGHPC-VQWEPG------NRCPGRCMGRAVRMQQRHTACQHNSSDSN 1579
+ K +P+ K C C W PG C G R ++ Q+ + + +
Sbjct: 914 SAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHS 973
Query: 1580 CDDRKRPTLRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCV 1639
PT + C S AC W GPW C+ CGRG + R++ C + + + + C
Sbjct: 974 LCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLC-KGSAAETLPESQCT 1032
Query: 1640 QKKKPISWRHCLGPSCDRD 1658
+P C+ C ++
Sbjct: 1033 SLPRPELQEGCVLGRCPKN 1051
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 285 bits (730), Expect = 2e-76
Identities = 183/583 (31%), Positives = 272/583 (46%), Gaps = 91/583 (15%)
Query: 72 EDKDGNWDAWGDWSDCSRTCGGGASYSLRRC------LTGRNCEGQNIRYKTCSNHDCPP 125
E DG W W W DCSRTCGGG S S R C + G+ C G+ R+++C+ DCPP
Sbjct: 544 EGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPP 603
Query: 126 DAEDFRAQQCSAYNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLDGTR 185
++DFR QCS ++ + ++G +Y+W C+L C A+G N E A V+DGT
Sbjct: 604 GSQDFREVQCSEFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTP 663
Query: 186 CNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKREE 245
C D++D+C+SG C+ VGCDR LGS+ +ED C VC GDGS C + G S SP E
Sbjct: 664 CRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVF-SPASPGAGYE 722
Query: 246 NVIAVPLGSRSVRITVK----GPAHLFI----ESKTLQGSKGEHSFNSPGVFLVENTTVE 297
+V+ +P G SV I ++ +HL + ES L+G G P + TT +
Sbjct: 723 DVVWIPKG--SVHIFIQDLNLSLSHLALKGDQESLLLEGLPGT---PQPHRLPLAGTTFQ 777
Query: 298 FQRGSER-QTFKIPGPLMADFIFKTRYTAAKDSVVQFFFYQPIS------HQWRQTDFFP 350
++G ++ Q+ + GP+ A I + +++ F PI+ + W +
Sbjct: 778 LRQGPDQVQSLEALGPINASLIVMV-LARTELPALRYRFNAPIARDSLPPYSWHYAPWTK 836
Query: 351 CTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEI 410
C+ C GG Q+ + EC + V HYC + + K + + C+ +PCP
Sbjct: 837 CSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPK---RQRACNTEPCP-------- 885
Query: 411 MPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKV 470
P W W+ CS SC G++ RS VC E +++ C P+P V
Sbjct: 886 ---------PDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACP-QPRPPV 935
Query: 471 MQTCNLFDC-PKWIAMEWSQCTVTCGRGLRYRVVLC--INHRGEHVGGCNPQLKLHIKEE 527
++ C+ C P+W A++WS+CT +CG GLR+RVVLC +HR
Sbjct: 936 LEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHR------------------ 977
Query: 528 CVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVR 587
+P P K P + + ++ W CS CG G + R
Sbjct: 978 ATLPPAHCSPAAKPPATMRCNLRR-----------CPPARWVAGEWGECSAQCGVGQRQR 1026
Query: 588 EVKCRVLLTFTQTETELPEEEC-EGPKLPTERPCLLEACDESP 629
V+C + T EC E + PT + C EA +SP
Sbjct: 1027 SVRC-------TSHTGQASHECTEALRPPTTQQC--EAKCDSP 1060
Score = 145 bits (367), Expect = 2e-34
Identities = 76/226 (33%), Positives = 103/226 (45%), Gaps = 8/226 (3%)
Query: 627 ESPASR-ELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLC 685
E PA R + P+ DS Y W YA +T C+A C GG Q C + V C
Sbjct: 807 ELPALRYRFNAPIARDSLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYC 866
Query: 686 DMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLH----PGETPAPPE 741
+ P +ACNTEPCPP W VG+W CS +C G+++R V C E
Sbjct: 867 SAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDS 926
Query: 742 ECRDEKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDE 801
C +P L+AC+ CPP W +W +C+ +CG G ++R V C+ D
Sbjct: 927 ACPQPRPPVLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKS--ADHRATLPPAH 984
Query: 802 LCQGPKASSHKSCARTDCPP-HLAVGDWSKCSVSCGVGIQRRKQVC 846
K + C CPP G+W +CS CGVG ++R C
Sbjct: 985 CSPAAKPPATMRCNLRRCPPARWVAGEWGECSAQCGVGQRQRSVRC 1030
Score = 112 bits (279), Expect = 4e-24
Identities = 57/180 (31%), Positives = 82/180 (45%), Gaps = 6/180 (3%)
Query: 704 PPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPA-PPEEC--RDEKPHALQACNQFDCP 760
P WH W CSA C G Q + V C + ++ A P C + P +ACN CP
Sbjct: 826 PYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCP 885
Query: 761 PGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCP 820
P W + W CSR+C G ++R V C++ ++ L D C P+ ++C CP
Sbjct: 886 PDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCP 945
Query: 821 PHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQMPEC 880
P A DWS+C+ SCG G++ R +C+ + R L C P C + C
Sbjct: 946 PEWAALDWSECTPSCGPGLRHRVVLCK---SADHRATLPPAHCSPAAKPPATMRCNLRRC 1002
Score = 108 bits (271), Expect = 3e-23
Identities = 84/306 (27%), Positives = 119/306 (38%), Gaps = 33/306 (10%)
Query: 1405 LQATNTRTNSNDPTGEPPPQEPFWEPGNWSHCSATCGHLGARIQRPQCV-MANGQEVSEA 1463
L A R N+ PP W W+ CSA C G+++Q +C + V+
Sbjct: 808 LPALRYRFNAPIARDSLPPYS--WHYAPWTKCSAQCAG-GSQVQAVECRNQLDSSAVAPH 864
Query: 1464 LCDHLQKPLAGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVS 1523
C K CN CP W WS CS SC G SR V C+R + + +
Sbjct: 865 YCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALD 924
Query: 1524 PRACAPKDRPLGRKPCFGHPC-VQWE--PGNRCPGRCMGRAVRMQQRHTACQ---HNSS- 1576
AC P+ RP + C G C +W + C C ++ R C+ H ++
Sbjct: 925 DSAC-PQPRPPVLEACHGPTCPPEWAALDWSECTPSC---GPGLRHRVVLCKSADHRATL 980
Query: 1577 -DSNCDDRKRPTLRRNCTSGACDVC-WHTGPWKPCTAACGRGFQSRKVDCI-HTRSCKPV 1633
++C +P C C W G W C+A CG G + R V C HT
Sbjct: 981 PPAHCSPAAKPPATMRCNLRRCPPARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQ---- 1036
Query: 1634 AKRHCVQKKKPISWRHCLGPSCD--------RDCTDTTH--YCMFVKHLNLCSLDRYKQR 1683
A C + +P + + C CD +C D YC V CS ++Q
Sbjct: 1037 ASHECTEALRPPTTQQC-EAKCDSPTPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQM 1095
Query: 1684 CCQSCQ 1689
CC++CQ
Sbjct: 1096 CCKTCQ 1101
Score = 82.8 bits (203), Expect = 3e-15
Identities = 92/365 (25%), Positives = 129/365 (35%), Gaps = 100/365 (27%)
Query: 422 WEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPK 481
W + PWT CS C GG Q ++ C + + + ++ PK + CN CP
Sbjct: 829 WHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAV--APHYCSAHSKLPKRQRACNTEPCPP 886
Query: 482 -WIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEK 540
W+ WS C+ +C G+R R V+C Q ++ EE + P+ +
Sbjct: 887 DWVVGNWSLCSRSCDAGVRSRSVVC-------------QRRVSAAEEKALDDSAC-PQPR 932
Query: 541 SPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQT 600
PV LE T P + WS C+ +CGPG++ R V C+
Sbjct: 933 PPV------------LEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCK----SADH 976
Query: 601 ETELPEEECE-GPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTAT 659
LP C K P C L C P +R W + C+A
Sbjct: 977 RATLPPAHCSPAAKPPATMRCNLRRC---PPAR---------------WVAGEWGECSAQ 1018
Query: 660 C-VGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSAT 718
C VG Q ++ H T Q ++ C RPP Q C A
Sbjct: 1019 CGVGQRQRSVRCTSH--TGQASHE--CTEALRPPTTQQ------------------CEAK 1056
Query: 719 CGVGIQTRDVYCLHPGETPAP---PEECRDEKPHA---LQACNQFDCPPGWHIEEWQQCS 772
C ++P P PEEC+D A L QF C + Q C
Sbjct: 1057 C---------------DSPTPGDGPEECKDVNKVAYCPLVLKFQF-CSRAYF---RQMCC 1097
Query: 773 RTCGG 777
+TC G
Sbjct: 1098 KTCQG 1102
Score = 43.1 bits (100), Expect = 0.002
Identities = 22/61 (36%), Positives = 29/61 (47%), Gaps = 2/61 (3%)
Query: 712 WGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQQC 771
WG CS TCG G+ + +C P T + + H ++CN DCPPG QC
Sbjct: 556 WGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRH--RSCNTDDCPPGSQDFREVQC 613
Query: 772 S 772
S
Sbjct: 614 S 614
Score = 40.8 bits (94), Expect = 0.011
Identities = 20/54 (37%), Positives = 25/54 (46%), Gaps = 6/54 (11%)
Query: 768 WQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPP 821
W CSRTCGGG + C D + + C G + H+SC DCPP
Sbjct: 556 WGDCSRTCGGGVSSSSRHC-----DSPRPTIGGKYCLGER-RRHRSCNTDDCPP 603
Score = 32.0 bits (71), Expect = 5.2
Identities = 30/112 (26%), Positives = 43/112 (38%), Gaps = 28/112 (25%)
Query: 1556 RCMGRAVRMQQRHTACQHNSSDSN-CDDRKRPTLRRNCTSGACDVCWHTGPWKP---CTA 1611
RC+ ++ + T CQ ++ D C KR + D W GPW P C+
Sbjct: 507 RCITNSIPAAEG-TLCQTHTIDKGWC--YKRVCVPFGSRPEGVDGAW--GPWTPWGDCSR 561
Query: 1612 ACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGP-----SCDRD 1658
CG G S + RHC + I ++CLG SC+ D
Sbjct: 562 TCGGGVSS--------------SSRHCDSPRPTIGGKYCLGERRRHRSCNTD 599
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif, 6
preproprotein [Homo sapiens]
Length = 1117
Score = 285 bits (730), Expect = 2e-76
Identities = 175/579 (30%), Positives = 273/579 (47%), Gaps = 80/579 (13%)
Query: 75 DGNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPPDAE 128
DG W W W +CSRTCGGG S SLR C + G+ C G+ RY++C+ CP +
Sbjct: 558 DGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSR 617
Query: 129 DFRAQQCSAYNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLDGTRCNT 188
DFR +QC+ ++++ ++G YY W P PCAL C A+G N E AP V+DGT+CN
Sbjct: 618 DFREKQCADFDNMPFRGKYYNWKPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQCNA 677
Query: 189 DSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKREENVI 248
DSLD+CI+G C+ VGCD LGS+A+ED C VC GDGSTC + G + P V+
Sbjct: 678 DSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSL-PRGGYMEVV 736
Query: 249 AVPLGSRSVRITVKGPAHLFIESKTLQGS----KGEHSFNSPGVFLVENTTVEFQRGS-E 303
+P GS + + + +I K+ +G G + + P F V T ++R + E
Sbjct: 737 QIPRGSVHIEVREVAMSKNYIALKS-EGDDYYINGAWTIDWPRKFDVAGTAFHYKRPTDE 795
Query: 304 RQTFKIPGPLMADFIFKTRYTAAKDSVVQFFFYQPISH----------QWRQTDFFPCTV 353
++ + GP + I ++ +++ F PI+ W + C+
Sbjct: 796 PESLEALGPTSENLIVMV-LLQEQNLGIRYKFNVPITRTGSGDNEVGFTWNHQPWSECSA 854
Query: 354 TCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPY 413
TC GG Q C + +V ++YC P++ KP + C+ +PCP
Sbjct: 855 TCAGGVQRQEVVCKRLDDNSIVQNNYCD--PDS-KPPENQRACNTEPCP----------- 900
Query: 414 DHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQT 473
P W W CS +C GG++ R+ +C+ + E ++ C+ +P +
Sbjct: 901 ------PEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCL-THRPVEKEP 953
Query: 474 CNLFDC-PKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPI 532
CN C P+W+A++WS+CT CG G ++R+VLC + +
Sbjct: 954 CNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSS----------------------DL 991
Query: 533 PCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCR 592
P + P E+K P + + P ++ W CS CG G Q+R V+C
Sbjct: 992 SKTFPAAQCPEESKPP-----VRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQC- 1045
Query: 593 VLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPAS 631
L++T + + E + P+ + C CD +P S
Sbjct: 1046 --LSYT---GQASSDCLETVRPPSMQQC-ESKCDSTPIS 1078
Score = 151 bits (382), Expect = 5e-36
Identities = 88/266 (33%), Positives = 121/266 (45%), Gaps = 42/266 (15%)
Query: 613 KLPTERPCLLEACDESPASREL-----------------DIPLPE----DSETTYDWEYA 651
K PT+ P LEA P S L ++P+ D+E + W +
Sbjct: 790 KRPTDEPESLEAL--GPTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEVGFTWNHQ 847
Query: 652 GFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGS 711
++ C+ATC GG Q VC + V ++ CD +PP +ACNTEPCPP W +G
Sbjct: 848 PWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGD 907
Query: 712 WGPCSATCGVGIQTRDVYCLHPGETPAPPEE-------CRDEKPHALQACNQFDCPPGWH 764
W CS TC G++TR V C+ P EE C +P + CN CPP W
Sbjct: 908 WLECSKTCDGGMRTRAVLCI---RKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWV 964
Query: 765 IEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASS---HKSCARTDC-P 820
+W +C+ CG G ++R V C+ S L+ + Q P+ S C+ C P
Sbjct: 965 ALDWSECTPKCGPGFKHRIVLCK-----SSDLSKTFPAAQCPEESKPPVRIRCSLGRCPP 1019
Query: 821 PHLAVGDWSKCSVSCGVGIQRRKQVC 846
P GDW +CS CG+G Q R C
Sbjct: 1020 PRWVTGDWGQCSAQCGLGQQMRTVQC 1045
Score = 123 bits (308), Expect = 2e-27
Identities = 85/285 (29%), Positives = 117/285 (41%), Gaps = 36/285 (12%)
Query: 1428 WEPGNWSHCSATCGHLGARIQRPQCV---MANGQEVSEALCDHLQKPLAGFEPCNIRDCP 1484
W WS CSATC +QR + V + + V CD KP CN CP
Sbjct: 844 WNHQPWSECSATCA---GGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCP 900
Query: 1485 ARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPC 1544
WF W +CS +C G +R V C R + + C RP+ ++PC C
Sbjct: 901 PEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCL-THRPVEKEPCNNQSC 959
Query: 1545 -VQWE--PGNRCPGRCMGRAVRMQQRHTACQHNSSD-------SNCDDRKRPTLRRNCTS 1594
QW + C +C + R C+ SSD + C + +P +R C+
Sbjct: 960 PPQWVALDWSECTPKC---GPGFKHRIVLCK--SSDLSKTFPAAQCPEESKPPVRIRCSL 1014
Query: 1595 GAC-DVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGP 1653
G C W TG W C+A CG G Q R V C+ S A C++ +P S + C
Sbjct: 1015 GRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCL---SYTGQASSDCLETVRPPSMQQC-ES 1070
Query: 1654 SCD-------RDCTDTTH--YCMFVKHLNLCSLDRYKQRCCQSCQ 1689
CD +C D YC V CS ++Q CC++CQ
Sbjct: 1071 KCDSTPISNTEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQ 1115
Score = 107 bits (267), Expect = 1e-22
Identities = 70/226 (30%), Positives = 98/226 (43%), Gaps = 29/226 (12%)
Query: 567 TFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACD 626
T+ +PWS CS TC GVQ +EV C+ L + + C+ P E AC+
Sbjct: 843 TWNHQPWSECSATCAGGVQRQEVVCKRL----DDNSIVQNNYCDPDSKPPENQ---RACN 895
Query: 627 ESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLH---IQTQQTVNDS 683
P E W + C+ TC GG + +C+ ++T++ S
Sbjct: 896 TEPCPPE--------------WFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYS 941
Query: 684 LCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPA-PPEE 742
C + HR P + CN + CPP+W W C+ CG G + R V C + P +
Sbjct: 942 GC-LTHR-PVEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQ 999
Query: 743 CRDE-KPHALQACNQFDC-PPGWHIEEWQQCSRTCGGGTQNRRVTC 786
C +E KP C+ C PP W +W QCS CG G Q R V C
Sbjct: 1000 CPEESKPPVRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQC 1045
Score = 97.8 bits (242), Expect = 8e-20
Identities = 56/193 (29%), Positives = 81/193 (41%), Gaps = 20/193 (10%)
Query: 707 WHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRD---EKPHALQACNQFDCPPGW 763
W+ W CSATC G+Q ++V C + D + P +ACN CPP W
Sbjct: 844 WNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEW 903
Query: 764 HIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHL 823
I +W +CS+TC GG + R V C + + L C + + C CPP
Sbjct: 904 FIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQW 963
Query: 824 AVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQMPECSKI 883
DWS+C+ CG G + R +C+ S + + P + Q PE SK
Sbjct: 964 VALDWSECTPKCGPGFKHRIVLCK-----------SSDLSKTFP------AAQCPEESKP 1006
Query: 884 KSEMKTKLGEQGP 896
++ LG P
Sbjct: 1007 PVRIRCSLGRCPP 1019
Score = 86.7 bits (213), Expect = 2e-16
Identities = 74/299 (24%), Positives = 115/299 (38%), Gaps = 61/299 (20%)
Query: 482 WIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKS 541
W WS+C+ TC G++ + V+C + + ++ P K
Sbjct: 844 WNHQPWSECSATCAGGVQRQEVVC----------------KRLDDNSIVQNNYCDPDSKP 887
Query: 542 PVEAKLPWLKQAQELEETRIATEEPT----FIPEPWSACSTTCGPGVQVREVKCRVLLTF 597
P E R EP FI + W CS TC G++ R V C +
Sbjct: 888 P--------------ENQRACNTEPCPPEWFIGD-WLECSKTCDGGMRTRAVLCIRKIGP 932
Query: 598 TQTETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCT 657
++ ET L C + + PC ++C W ++ CT
Sbjct: 933 SEEET-LDYSGCLTHRPVEKEPCNNQSCPPQ-------------------WVALDWSECT 972
Query: 658 ATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPP-RWHVGSWGPCS 716
C G + I +C +T + C +PP + C+ CPP RW G WG CS
Sbjct: 973 PKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIR-CSLGRCPPPRWVTGDWGQCS 1031
Query: 717 ATCGVGIQTRDVYCLHPGETPAPPEECRDE-KPHALQAC-NQFDCPPGWHIEEWQQCSR 773
A CG+G Q R V CL T +C + +P ++Q C ++ D P + EE + ++
Sbjct: 1032 AQCGLGQQMRTVQCL--SYTGQASSDCLETVRPPSMQQCESKCDSTPISNTEECKDVNK 1088
Score = 36.2 bits (82), Expect = 0.28
Identities = 33/126 (26%), Positives = 43/126 (34%), Gaps = 23/126 (18%)
Query: 712 WGPCSATCGVGIQTRDVYCLHPGET------PAPPEECRDEKPHALQACNQFDCPP---- 761
+G S C G R+++CL PA C Q DC P
Sbjct: 494 YGATSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTW 553
Query: 762 ------GWHIEE-WQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSC 814
GW W +CSRTCGGG + C G + C G + ++SC
Sbjct: 554 PQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSG-----GGKYCLGER-KRYRSC 607
Query: 815 ARTDCP 820
CP
Sbjct: 608 NTDPCP 613
Score = 34.3 bits (77), Expect = 1.1
Identities = 16/59 (27%), Positives = 21/59 (35%)
Query: 1586 PTLRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKP 1644
P R W+ PW C+A C G Q ++V C V +C KP
Sbjct: 829 PITRTGSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKP 887
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1 motif,
16 preproprotein [Homo sapiens]
Length = 1224
Score = 282 bits (722), Expect = 2e-75
Identities = 211/678 (31%), Positives = 300/678 (44%), Gaps = 104/678 (15%)
Query: 59 RYDDQTSRNTRSDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQN 112
+Y D+ + T G+W W WS CSRTCGGG S+ R C G+ CEG
Sbjct: 576 KYGDEGPKPTH------GHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGST 629
Query: 113 IRYKTCSNHDCPPDAEDFRAQQCSAYNDVQYQGHYYEWLPRYN-DPAAPCALKCHAQGQN 171
K C++ CP D+ DFRA QC+ +N +++G +Y+W P + C L C A+G +
Sbjct: 630 RTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKLYCIAEGFD 689
Query: 172 LVVELAPKVLDGTRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVR 231
L+ KV DGT C+ DS ++CI GIC+ VGCD LGS+A ED CGVC G+ S C + R
Sbjct: 690 FFFSLSNKVKDGTPCSEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHR 749
Query: 232 GQSKSHVSPEKREENVIAVPLGSRSVRITVKGPAHLFIESKTLQGS---KGEHSFNSPGV 288
G H + +++ +P G+RS+RI + +I + G + + PG
Sbjct: 750 GLYTKH-HHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHWTVDWPGR 808
Query: 289 FLVENTTVEFQRG-SERQTFKIPGP----LMADFIFKTR-------YTAAKDSVVQFFFY 336
+ TT +++R +E + GP L+ + +F+ R Y+ + +
Sbjct: 809 YKFSGTTFDYRRSYNEPENLIATGPTNETLIVELLFQGRNPGVAWEYSMPRLGTEKQPPA 868
Query: 337 QPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKEC 396
QP S+ W C+V+CGGG Q+ E LK V +C+ +P L C
Sbjct: 869 QP-SYTWAIVR-SECSVSCGGG-QMTVREGCYRDLKFQVNMSFCN---PKTRPVTGLVPC 922
Query: 397 SMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQ 456
+ CP P W W+ACS +CGGG Q R C +H +
Sbjct: 923 KVSACP-----------------PSWSVGNWSACSRTCGGGAQSRPVQCTRR-VHYDSEP 964
Query: 457 VEEWKCMYAPKPKVMQTCNLFDC-PKWIAMEWSQCTVTCGRGLRYRVVLC----INHRGE 511
V C P P Q CN C P W A W++C+ TCG+G R R V C + R +
Sbjct: 965 VPASLCP-QPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQ 1023
Query: 512 HV--GGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFI 569
+ C + K + E C++ C+KPK KL WL A
Sbjct: 1024 LLPDAVCTSEPKPRMHEACLLQ-RCHKPK-------KLQWLVSA---------------- 1059
Query: 570 PEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECE---GPKLPTERPCLLEACD 626
WS CS TC G Q R +KC + EL ++C P L ER C C
Sbjct: 1060 ---WSQCSVTCERGTQKRFLKCAEKYV-SGKYRELASKKCSHLPKPSLELERACAPLPCP 1115
Query: 627 ESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCD 686
P P + W + ++ CTA+C GG Q CL S C
Sbjct: 1116 RHP-------PFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPA----SGC- 1163
Query: 687 MVHRPPAMSQACNTEPCP 704
++H+ P+ S ACNT CP
Sbjct: 1164 LLHQKPSASLACNTHFCP 1181
Score = 147 bits (370), Expect = 1e-34
Identities = 86/251 (34%), Positives = 110/251 (43%), Gaps = 12/251 (4%)
Query: 642 SETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTE 701
++ +Y W + C+ +C GG C Q VN S C+ RP C
Sbjct: 868 AQPSYTWAIVR-SECSVSCGGGQMTVREGCYRDLKFQ-VNMSFCNPKTRPVTGLVPCKVS 925
Query: 702 PCPPRWHVGSWGPCSATCGVGIQTRDVYC---LHPGETPAPPEECRDEKPHALQACNQFD 758
CPP W VG+W CS TCG G Q+R V C +H P P C P + QACN
Sbjct: 926 ACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQS 985
Query: 759 CPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQG-PKASSHKSCART 817
CPP W W +CS TCG G + R V C+ L D +C PK H++C
Sbjct: 986 CPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQ 1045
Query: 818 DC--PPHL--AVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDL--PGLPL 871
C P L V WS+CSV+C G Q+R C G+ L+ C L P L L
Sbjct: 1046 RCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLEL 1105
Query: 872 VRSCQMPECSK 882
R+C C +
Sbjct: 1106 ERACAPLPCPR 1116
Score = 130 bits (327), Expect = 1e-29
Identities = 83/300 (27%), Positives = 132/300 (44%), Gaps = 42/300 (14%)
Query: 1426 PFWEPGNWSHCSATCGHLGARIQRPQC---VMANGQEVSEALCDHLQKPLAGFEPCNIRD 1482
P W GNWS CS TCG GA+ + QC V + + V +LC Q + + CN +
Sbjct: 929 PSWSVGNWSACSRTCGG-GAQSRPVQCTRRVHYDSEPVPASLCP--QPAPSSRQACNSQS 985
Query: 1483 CPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGH 1542
CP W W++CS +CG+G+ R V CK T + Q++ C + +P + C
Sbjct: 986 CPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQ 1045
Query: 1543 PC-----VQW--EPGNRCPGRC----MGRAVRMQQRHTACQHNS-SDSNCDDRKRPT--L 1588
C +QW ++C C R ++ +++ + ++ + C +P+ L
Sbjct: 1046 RCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLEL 1105
Query: 1589 RRNC------------TSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKR 1636
R C +G W PW CTA+CG G Q+R V C+ +P +
Sbjct: 1106 ERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCL--AGGRPAS-- 1161
Query: 1637 HCVQKKKPISWRHCLGPSC------DRDCTDTTHYCMFVKHLNLCSLDRYKQRCCQSCQE 1690
C+ +KP + C C D C D H+C V +CS Y ++CC++C +
Sbjct: 1162 GCLLHQKPSASLACNTHFCPIAEKKDAFCKDYFHWCYLVPQHGMCSHKFYGKQCCKTCSK 1221
Score = 124 bits (310), Expect = 1e-27
Identities = 97/333 (29%), Positives = 131/333 (39%), Gaps = 70/333 (21%)
Query: 553 AQELEETRIATEE--PTFIPEPW----SACSTTCGPGVQV------REVKCRVLLTFTQT 600
A E R+ TE+ P W S CS +CG G R++K +V ++F
Sbjct: 852 AWEYSMPRLGTEKQPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDLKFQVNMSFCNP 911
Query: 601 ETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATC 660
+T + PC + AC S W ++ C+ TC
Sbjct: 912 KTR---------PVTGLVPCKVSACPPS-------------------WSVGNWSACSRTC 943
Query: 661 VGGHQEAIAVC---LHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSA 717
GG Q C +H ++ V SLC P+ QACN++ CPP W G W CS
Sbjct: 944 GGGAQSRPVQCTRRVHYDSEP-VPASLCPQP--APSSRQACNSQSCPPAWSAGPWAECSH 1000
Query: 718 TCGVGIQTRDVYCLHPGETPA----PPEECRDE-KPHALQACNQFDCPPG----WHIEEW 768
TCG G + R V C + P C E KP +AC C W + W
Sbjct: 1001 TCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSAW 1060
Query: 769 QQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQG---PKASSHKSCARTDCPPH--- 822
QCS TC GTQ R + C + G + L+ + C P ++CA CP H
Sbjct: 1061 SQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPF 1120
Query: 823 LAVGD---------WSKCSVSCGVGIQRRKQVC 846
A G WS+C+ SCG G+Q R C
Sbjct: 1121 AAAGPSRGSWFASPWSQCTASCGGGVQTRSVQC 1153
Score = 109 bits (272), Expect = 3e-23
Identities = 95/352 (26%), Positives = 134/352 (38%), Gaps = 72/352 (20%)
Query: 430 CSVSCGGGIQRRSFVCVEESMHGEI-LQVEEWKCMYAPKPKV-MQTCNLFDCP-KWIAME 486
CSVSCGGG + V E + ++ QV C +P + C + CP W
Sbjct: 881 CSVSCGGGQ-----MTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGN 935
Query: 487 WSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAK 546
WS C+ TCG G + R V C ++H E V C +P S
Sbjct: 936 WSACSRTCGGGAQSRPVQCTR-------------RVHYDSEPVPASLCPQPAPSS----- 977
Query: 547 LPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPE 606
+QA + P + PW+ CS TCG G + R V C+ + + LP+
Sbjct: 978 ----RQACNSQSC-----PPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQL-LPD 1027
Query: 607 EECEG-PKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQ 665
C PK CLL+ C + + W + ++ C+ TC G Q
Sbjct: 1028 AVCTSEPKPRMHEACLLQRCHKPKKLQ---------------WLVSAWSQCSVTCERGTQ 1072
Query: 666 EAIAVCLHIQTQ---QTVNDSLCDMVHRPPA-MSQACNTEPCPPR------------WHV 709
+ C + + C + +P + +AC PCP W
Sbjct: 1073 KRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFA 1132
Query: 710 GSWGPCSATCGVGIQTRDVYCLHPGETPAPPEEC-RDEKPHALQACNQFDCP 760
W C+A+CG G+QTR V CL G P C +KP A ACN CP
Sbjct: 1133 SPWSQCTASCGGGVQTRSVQCLAGGR---PASGCLLHQKPSASLACNTHFCP 1181
Score = 102 bits (253), Expect = 4e-21
Identities = 74/250 (29%), Positives = 104/250 (41%), Gaps = 17/250 (6%)
Query: 642 SETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTE 701
S TT+D+ + P G E + V L Q + N + P TE
Sbjct: 812 SGTTFDYRRSYNEPENLIATGPTNETLIVELLFQGR---NPGVAWEYSMP-----RLGTE 863
Query: 702 PCPPRWHVGSWG----PCSATCGVGIQTRDVYCLHPGETPAPPEECRDE-KP-HALQACN 755
PP +W CS +CG G T C + C + +P L C
Sbjct: 864 KQPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCK 923
Query: 756 QFDCPPGWHIEEWQQCSRTCGGGTQNRRVTC-RQLLTDGSFLNLSDELCQGPKASSHKSC 814
CPP W + W CSRTCGGG Q+R V C R++ D + S LC P SS ++C
Sbjct: 924 VSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPAS--LCPQPAPSSRQAC 981
Query: 815 ARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRS 874
CPP + G W++CS +CG G ++R C+ R L + +C P + +
Sbjct: 982 NSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEA 1041
Query: 875 CQMPECSKIK 884
C + C K K
Sbjct: 1042 CLLQRCHKPK 1051
Score = 93.2 bits (230), Expect = 2e-18
Identities = 68/249 (27%), Positives = 98/249 (39%), Gaps = 31/249 (12%)
Query: 1418 TGEPPPQEPFWEPGNW----SHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLA 1473
T + PP +P + W S CS +CG G R C +V+ + C+ +P+
Sbjct: 862 TEKQPPAQPSY---TWAIVRSECSVSCGG-GQMTVREGCYRDLKFQVNMSFCNPKTRPVT 917
Query: 1474 GFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRP 1533
G PC + CP W WS CS +CG G SR V C R + V P + P+ P
Sbjct: 918 GLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPV--PASLCPQPAP 975
Query: 1534 LGRKPCFGHPC-VQWE--PGNRCPGRCMGRAVRMQQRHTACQHNS--------SDSNCDD 1582
R+ C C W P C C G+ R +R AC+ + D+ C
Sbjct: 976 SSRQACNSQSCPPAWSAGPWAECSHTC-GKGWR--KRAVACKSTNPSARAQLLPDAVCTS 1032
Query: 1583 RKRPTLRRNCTSGAC----DVCWHTGPWKPCTAACGRGFQSRKVDCIH---TRSCKPVAK 1635
+P + C C + W W C+ C RG Q R + C + + +A
Sbjct: 1033 EPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELAS 1092
Query: 1636 RHCVQKKKP 1644
+ C KP
Sbjct: 1093 KKCSHLPKP 1101
Score = 86.7 bits (213), Expect = 2e-16
Identities = 76/325 (23%), Positives = 116/325 (35%), Gaps = 76/325 (23%)
Query: 488 SQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKL 547
S+C+V+CG G + + GC LK + P + PV +
Sbjct: 879 SECSVSCGGGQ-----MTVRE------GCYRDLKFQVNMSFCNP-------KTRPVTGLV 920
Query: 548 PWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEE 607
P +++ P++ WSACS TCG G Q R V+C + + +P
Sbjct: 921 P----------CKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEP--VPAS 968
Query: 608 ECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEA 667
C P + + C ++C + W + C+ TC G ++
Sbjct: 969 LCPQPAPSSRQACNSQSCPPA-------------------WSAGPWAECSHTCGKGWRKR 1009
Query: 668 IAVCLHIQTQ---QTVNDSLCDMVHRPPAMSQACNTEPCPP----RWHVGSWGPCSATCG 720
C Q + D++C +P M +AC + C +W V +W CS TC
Sbjct: 1010 AVACKSTNPSARAQLLPDAVCTSEPKP-RMHEACLLQRCHKPKKLQWLVSAWSQCSVTCE 1068
Query: 721 VGIQTRDVYCLHPGETPAPPEECRDEKPHALQ-------ACNQFDCPP------------ 761
G Q R + C + E + H + AC CP
Sbjct: 1069 RGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRG 1128
Query: 762 GWHIEEWQQCSRTCGGGTQNRRVTC 786
W W QC+ +CGGG Q R V C
Sbjct: 1129 SWFASPWSQCTASCGGGVQTRSVQC 1153
Score = 38.9 bits (89), Expect = 0.043
Identities = 18/50 (36%), Positives = 24/50 (48%), Gaps = 2/50 (4%)
Query: 711 SWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCP 760
SW PCS TCG G+ R C +P P+ + + L+ CN CP
Sbjct: 594 SWSPCSRTCGGGVSHRSRLCTNP--KPSHGGKFCEGSTRTLKLCNSQKCP 641
Score = 36.2 bits (82), Expect = 0.28
Identities = 24/68 (35%), Positives = 30/68 (44%), Gaps = 5/68 (7%)
Query: 1417 PTGEPPPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFE 1476
P P W WS C+A+CG G + + QC +A G+ S L QKP A
Sbjct: 1119 PFAAAGPSRGSWFASPWSQCTASCGG-GVQTRSVQC-LAGGRPASGCLLH--QKPSASL- 1173
Query: 1477 PCNIRDCP 1484
CN CP
Sbjct: 1174 ACNTHFCP 1181
Score = 31.6 bits (70), Expect = 6.8
Identities = 11/19 (57%), Positives = 12/19 (63%)
Query: 768 WQQCSRTCGGGTQNRRVTC 786
W CSRTCGGG +R C
Sbjct: 595 WSPCSRTCGGGVSHRSRLC 613
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1 motif,
19 preproprotein [Homo sapiens]
Length = 1207
Score = 265 bits (678), Expect = 2e-70
Identities = 182/594 (30%), Positives = 261/594 (43%), Gaps = 104/594 (17%)
Query: 64 TSRNTRSDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRC----LTGRNCEGQNIRYKTCS 119
TSR T + E G W W S CSRTC G S R+C R+C G +Y+ C
Sbjct: 626 TSR-TSAPEHLAGEWSLW---SPCSRTCSAGISSRERKCPGLDSEARDCNGPRKQYRICE 681
Query: 120 NHDCPPDAEDFRAQQCSAYN-DVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAP 178
N CP FR QC AY+ H +W D PCAL C G+ + L+
Sbjct: 682 NPPCPAGLPGFRDWQCQAYSVRTSSPKHILQW-QAVLDEEKPCALFCSPVGKEQPILLSE 740
Query: 179 KVLDGTRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHV 238
KV+DGT C LD+C +G CQ VGCD LGS A+ED+CGVC G+G +C++++G +H
Sbjct: 741 KVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDF-NHT 799
Query: 239 SPEKREENVIAVPLGSRSVRITVKGPAHLFIESKTLQGSKGEHSFNS------PGVFLVE 292
E V+ +P G+R +++ + PAH ++ + G+ S NS G F +
Sbjct: 800 RGAGYVE-VLVIPAGARRIKVVEEKPAHSYLALR----DAGKQSINSDWKIEHSGAFNLA 854
Query: 293 NTTVEFQRGSERQTFKIPGPLMA------------DFIFKTRYTAAKDSVVQ---FFFYQ 337
TTV + R + GP A ++ YT D + + +
Sbjct: 855 GTTVHYVRRGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPENQSSKAPE 914
Query: 338 PISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKR--VVPDHYCHYYPENVKPKPKLKE 395
P+ W T + C TCGGG + + C I K +V + C Y KP+P++++
Sbjct: 915 PL-FMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYL---TKPEPQIRK 970
Query: 396 CSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEIL 455
C+ PC + RW WT CS +CG G+Q R C ++ +G ++
Sbjct: 971 CNEQPCQT-----------------RWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLI 1013
Query: 456 QVEEWKCMYAPKPKVMQTCNLFDC-PKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVG 514
+ E C+ PKP Q C DC W A WS+C+V CG+G+R+R V C N R + V
Sbjct: 1014 RARERDCI-GPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKKCVL 1072
Query: 515 GCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWS 574
P+ E+C CY + WS
Sbjct: 1073 STRPR----EAEDCEDYSKCY-------------------------------VWRMGDWS 1097
Query: 575 ACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTE-RPCLLEACDE 627
CS TCG G+Q R ++C +T EC + P RPC L+ C+E
Sbjct: 1098 KCSITCGKGMQSRVIQCMHKITGRH------GNECFSSEKPAAYRPCHLQPCNE 1145
Score = 142 bits (359), Expect = 2e-33
Identities = 97/345 (28%), Positives = 142/345 (41%), Gaps = 48/345 (13%)
Query: 1375 KAVATSVLHLLERRWPESRIVFLQGHKKYILQATNTRTNSNDPTGEPPPQEPFWEPGNWS 1434
K T+ LHLL + + H +Y + + N + EP W +W
Sbjct: 872 KGPTTAPLHLLVLLFQDQNYGL---HYEYTIPSDPLPENQSSKAPEPLFM---WTHTSWE 925
Query: 1435 HCSATCGHLGARIQRPQCVMANGQEVS---EALCDHLQKPLAGFEPCNIRDCPARWFTSV 1491
C ATCG G R C + +S C +L KP CN + C RW +
Sbjct: 926 DCDATCGG-GERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTE 984
Query: 1492 WSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRAC-APKDRPLGRKPCFGHPCVQ-WEP 1549
W+ CS +CG+G SRQV C + +NGT+ R C PK P + C G C+ WE
Sbjct: 985 WTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPK--PASAQRCEGQDCMTVWEA 1042
Query: 1550 G--NRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGACDVCWHTGPWK 1607
G + C +C G+ + RH + + C RP +C + W G W
Sbjct: 1043 GVWSECSVKC-GKGI----RHRTVRCTNPRKKCVLSTRPREAEDCEDYSKCYVWRMGDWS 1097
Query: 1608 PCTAACGRGFQSRKVDCIHTRSCKPVAKRH---CVQKKKPISWRHCLGPSCDRDCTDTT- 1663
C+ CG+G QSR + C+H + RH C +KP ++R C C+ T
Sbjct: 1098 KCSITCGKGMQSRVIQCMH-----KITGRHGNECFSSEKPAAYRPCHLQPCNEKINVNTI 1152
Query: 1664 ------------------HYCMFVKHLNLCSLDRYKQRCCQSCQE 1690
YC ++ NLC R+ QRCC++C++
Sbjct: 1153 TSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETCRD 1197
Score = 123 bits (308), Expect = 2e-27
Identities = 70/221 (31%), Positives = 99/221 (44%), Gaps = 20/221 (9%)
Query: 637 PLPEDS-----ETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQT--VNDSLCDMVH 689
PLPE+ E + W + + C ATC GG ++ C I ++ V++ C +
Sbjct: 903 PLPENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLT 962
Query: 690 RPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYC---LHPGE-TPAPPEECRD 745
+P + CN +PC RW + W PCS TCG G+Q+R V C L G A +C
Sbjct: 963 KPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIG 1022
Query: 746 EKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQG 805
KP + Q C DC W W +CS CG G ++R V C N +
Sbjct: 1023 PKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRC---------TNPRKKCVLS 1073
Query: 806 PKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVC 846
+ + C +GDWSKCS++CG G+Q R C
Sbjct: 1074 TRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQC 1114
Score = 101 bits (252), Expect = 5e-21
Identities = 70/263 (26%), Positives = 106/263 (40%), Gaps = 41/263 (15%)
Query: 565 EPTFI--PEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLL 622
EP F+ W C TCG G + V C +++ + + + E+C K T+ +
Sbjct: 914 EPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMS--KNISIVDNEKC---KYLTKPEPQI 968
Query: 623 EACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVND 682
C+E P W +TPC+ TC G Q C TQQ N
Sbjct: 969 RKCNEQPCQTR--------------WMMTEWTPCSRTCGKGMQSRQVAC----TQQLSNG 1010
Query: 683 SLC-----DMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETP 737
+L D + PA +Q C + C W G W CS CG GI+ R V C +P +
Sbjct: 1011 TLIRARERDCIGPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRK-- 1068
Query: 738 APPEEC-RDEKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFL 796
+C +P + C + W + +W +CS TCG G Q+R + C +T
Sbjct: 1069 ----KCVLSTRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITG---- 1120
Query: 797 NLSDELCQGPKASSHKSCARTDC 819
+E K ++++ C C
Sbjct: 1121 RHGNECFSSEKPAAYRPCHLQPC 1143
Score = 81.6 bits (200), Expect = 6e-15
Identities = 68/279 (24%), Positives = 105/279 (37%), Gaps = 55/279 (19%)
Query: 482 WIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKS 541
W W C TCG G R V C +++ + + ++ + P P + +
Sbjct: 919 WTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTK----PEPQIRKCNEQ 974
Query: 542 PVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTE 601
P + + W+ TE W+ CS TCG G+Q R+V C L+ T
Sbjct: 975 PCQTR--WMM-----------TE--------WTPCSRTCGKGMQSRQVACTQQLS-NGTL 1012
Query: 602 TELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCV 661
E +C GPK + + C E + WE ++ C+ C
Sbjct: 1013 IRARERDCIGPKPASAQRC-------------------EGQDCMTVWEAGVWSECSVKCG 1053
Query: 662 GGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGV 721
G + C + + + C + RP + C W +G W CS TCG
Sbjct: 1054 KGIRHRTVRCTNPRKK-------CVLSTRPREAEDCEDYSKCYV-WRMGDWSKCSITCGK 1105
Query: 722 GIQTRDVYCLHPGETPAPPEEC-RDEKPHALQACNQFDC 759
G+Q+R + C+H T EC EKP A + C+ C
Sbjct: 1106 GMQSRVIQCMHK-ITGRHGNECFSSEKPAAYRPCHLQPC 1143
Score = 58.5 bits (140), Expect = 5e-08
Identities = 36/139 (25%), Positives = 62/139 (44%), Gaps = 11/139 (7%)
Query: 763 WHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQ---GPKASSHKSCARTDC 819
W W+ C TCGGG + V+C ++++ + + +E C+ P+ K C C
Sbjct: 919 WTHTSWEDCDATCGGGERKTTVSCTKIMSKNISI-VDNEKCKYLTKPEPQIRK-CNEQPC 976
Query: 820 PPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQMPE 879
+ +W+ CS +CG G+Q R+ C + + G I E C P + C+ +
Sbjct: 977 QTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIG-PKPASAQRCEGQD 1035
Query: 880 C-----SKIKSEMKTKLGE 893
C + + SE K G+
Sbjct: 1036 CMTVWEAGVWSECSVKCGK 1054
Score = 35.8 bits (81), Expect = 0.36
Identities = 65/252 (25%), Positives = 97/252 (38%), Gaps = 41/252 (16%)
Query: 815 ARTDCPPHLAVGDWS---KCSVSCGVGIQRRKQVCQRLAAKGRRI--PLSE-MMCRDLP- 867
+RT P HLA G+WS CS +C GI R++ C L ++ R P + +C + P
Sbjct: 627 SRTSAPEHLA-GEWSLWSPCSRTCSAGISSRERKCPGLDSEARDCNGPRKQYRICENPPC 685
Query: 868 --GLPLVRSCQMPECSKIKSEMKTKLGEQGPQILSVQRVYIQTREEKRINLTIGSRAYLL 925
GLP R Q S S K IL Q V + + +G +L
Sbjct: 686 PAGLPGFRDWQCQAYSVRTSSPK--------HILQWQAVLDEEKPCALFCSPVGKEQPIL 737
Query: 926 PNTSV----------IIKCPVRRFQK--------SLIQWEKDGRCLQNSKRLGITKSGSL 967
+ V + C R QK SL + + G C N K I K
Sbjct: 738 LSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDFN 797
Query: 968 KIHGLAAPDIGVYRCIAGSAQETVVLKLIGTDNRLIARPALREPMREYPGMDHSEA-NSL 1026
G ++ V I A+ V++ + L R A ++ + ++HS A N
Sbjct: 798 HTRGAGYVEVLV---IPAGARRIKVVEEKPAHSYLALRDAGKQSINSDWKIEHSGAFNLA 854
Query: 1027 GVTWHKMRQ-MW 1037
G T H +R+ +W
Sbjct: 855 GTTVHYVRRGLW 866
Score = 33.9 bits (76), Expect = 1.4
Identities = 22/76 (28%), Positives = 30/76 (39%), Gaps = 8/76 (10%)
Query: 698 CNTEPCPPRWHVGSWG---PCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQAC 754
C + P G W PCS TC GI +R+ C PG + +C + + C
Sbjct: 625 CTSRTSAPEHLAGEWSLWSPCSRTCSAGISSRERKC--PG-LDSEARDCNGPRKQ-YRIC 680
Query: 755 NQFDCPPGW-HIEEWQ 769
CP G +WQ
Sbjct: 681 ENPPCPAGLPGFRDWQ 696
Score = 33.1 bits (74), Expect = 2.3
Identities = 19/62 (30%), Positives = 25/62 (40%), Gaps = 9/62 (14%)
Query: 768 WQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHL-AVG 826
W CSRTC G +R C L ++ C GP+ ++ C CP L
Sbjct: 642 WSPCSRTCSAGISSRERKCPGLDSEA-------RDCNGPR-KQYRICENPPCPAGLPGFR 693
Query: 827 DW 828
DW
Sbjct: 694 DW 695
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 261 bits (667), Expect = 4e-69
Identities = 169/585 (28%), Positives = 250/585 (42%), Gaps = 106/585 (18%)
Query: 78 WDAWGDWSDCSRTCGGGASYSLRRCLT-----GRNCEGQNIRYKTCSNHDCPPDAEDFRA 132
W W WS CSRTCGGG S+ R C + G +C G +++C CP A DFRA
Sbjct: 29 WGPWSQWSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPARSHRSCRTESCPDGARDFRA 88
Query: 133 QQCSAYNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLDGTRCNTDSLD 192
+QC+ ++ ++QG Y WLP Y+ P C L C +G+N + V+DGT C D
Sbjct: 89 EQCAEFDGAEFQGRRYRWLPYYSAPNK-CELNCIPKGENFYYKHREAVVDGTPCEPGKRD 147
Query: 193 MCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKREENVIAVPL 252
+C+ G C+ VGCD +L S+ +ED C C GDG+TC V G ++
Sbjct: 148 VCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDANDL------------- 194
Query: 253 GSRSVRITVKGPAHLFIESKTLQGSKGEHSFNSPGVFLVENTTVEFQRGSE----RQTFK 308
SR+V+ V+G +L G + + +T + ++RG+E +
Sbjct: 195 -SRAVK-NVRGEYYL----------NGHWTIEAARALPAASTILHYERGAEGDLAPERLH 242
Query: 309 IPGPLMADFIFKTRYTAAKDSVVQFFFYQPI-----SHQWRQTDFFPCTVTCGGGYQLNS 363
GP + + + + V + ++ P+ W + C+ CGGG+Q
Sbjct: 243 ARGPTSEPLVIEL-ISQEPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQSRL 301
Query: 364 AEC-VDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRW 422
C +D PDH C P +P + + C++ PCP + RW
Sbjct: 302 VFCTID---HEAYPDHMCQRQP---RPADR-RSCNLHPCPET---------------KRW 339
Query: 423 EHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAP-KPKVMQTCNLFDCPK 481
+ PW CS SCGGG Q RS C+ G VEE +C P KP +Q CNL C
Sbjct: 340 KAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAA 399
Query: 482 WIAMEWSQCTVTCGRGLRYRVVLCINHRGE--HVGGCNPQLKLHIKEECVIPIPCYKPKE 539
W W +C+V+CG G+R R V C RG H C+ + + + E CV E
Sbjct: 400 WSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCV--------HE 451
Query: 540 KSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQ 599
P+ + W + T W CS +C G + R+V C +
Sbjct: 452 DCPLLSDQAW----------HVGT---------WGLCSKSCSSGTRRRQVICAI------ 486
Query: 600 TETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSET 644
P C L +P +E C+ P ++P +D T
Sbjct: 487 ----GPPSHC--GSLQHSKPVDVEPCNTQPCHLPQEVPSMQDVHT 525
Score = 137 bits (345), Expect = 9e-32
Identities = 138/499 (27%), Positives = 193/499 (38%), Gaps = 79/499 (15%)
Query: 400 PCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEE 459
P P S K D + P W W+ CS +CGGG+ R C + G
Sbjct: 13 PAPGSSAPKVRRQSDTWGP---WSQ--WSPCSRTCGGGVSFRERPCYSQRRDGGS----- 62
Query: 460 WKCMYAPKPKVMQTCNLFDCPKWIA-MEWSQCTVTCG---RGLRYRVVLCINHRGEHVGG 515
C+ + ++C CP QC G +G RYR + + +
Sbjct: 63 -SCVGPARSH--RSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPYYSAPNKCELN 119
Query: 516 CNPQ---LKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEP 572
C P+ +E V PC K V+ + EL+ ++ +E +
Sbjct: 120 CIPKGENFYYKHREAVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSK---QEDKCLR-- 174
Query: 573 WSACSTTCGPGV----------QVREVKCRVLLT---FTQTETELP--------EEECEG 611
TTC P V+ V+ L + LP E EG
Sbjct: 175 CGGDGTTCYPVAGTFDANDLSRAVKNVRGEYYLNGHWTIEAARALPAASTILHYERGAEG 234
Query: 612 P--------KLPTERPCLLEACDESP---ASRELDIPLPEDSETTYDWEYAGFTPCTATC 660
+ PT P ++E + P E +PL S + W + ++ C+A C
Sbjct: 235 DLAPERLHARGPTSEPLVIELISQEPNPGVHYEYHLPLRRPSPG-FSWSHGSWSDCSAEC 293
Query: 661 VGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPP--RWHVGSWGPCSAT 718
GGHQ + C + D +C RP A ++CN PCP RW G W PCSA+
Sbjct: 294 GGGHQSRLVFCTI--DHEAYPDHMCQRQPRP-ADRRSCNLHPCPETKRWKAGPWAPCSAS 350
Query: 719 CGVGIQTRDVYCLHPG----ETPAPPEECR--DEKPHALQACNQFDCPPGWHIEEWQQCS 772
CG G Q+R VYC+ + EC KP A+QACN C W E W +CS
Sbjct: 351 CGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC-AAWSPEPWGECS 409
Query: 773 RTCGGGTQNRRVTCRQLLTDGSFLNLSD-ELCQGPKASSHKSCARTDCP----PHLAVGD 827
+CG G + R VTCR GS L+ + L P + + C DCP VG
Sbjct: 410 VSCGVGVRKRSVTCRG--ERGSLLHTAACSLEDRPPLT--EPCVHEDCPLLSDQAWHVGT 465
Query: 828 WSKCSVSCGVGIQRRKQVC 846
W CS SC G +RR+ +C
Sbjct: 466 WGLCSKSCSSGTRRRQVIC 484
Score = 101 bits (251), Expect = 7e-21
Identities = 83/301 (27%), Positives = 114/301 (37%), Gaps = 65/301 (21%)
Query: 413 YDHFQPLPR------WEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAP 466
Y++ PL R W H W+ CS CGGG Q R C + + C P
Sbjct: 266 YEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQSRLVFCTIDHE-----AYPDHMCQRQP 320
Query: 467 KPKVMQTCNLFDCP---KWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLH 523
+P ++CNL CP +W A W+ C+ +CG G + R V CI+ G +
Sbjct: 321 RPADRRSCNLHPCPETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGI---------- 370
Query: 524 IKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPG 583
+E V C K P QA L+ + PEPW CS +CG G
Sbjct: 371 --QEAVEEAECAGLPGKPPAI-------QACNLQRCA------AWSPEPWGECSVSCGVG 415
Query: 584 VQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSE 643
V+ R V CR + + L C +RP L E C D PL D
Sbjct: 416 VRKRSVTCR-----GERGSLLHTAACS----LEDRPPLTEPCVHE------DCPLLSDQA 460
Query: 644 TTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLC-DMVHRPPAMSQACNTEP 702
W + C+ +C G + +C S C + H P + CNT+P
Sbjct: 461 ----WHVGTWGLCSKSCSSGTRRRQVICA------IGPPSHCGSLQHSKPVDVEPCNTQP 510
Query: 703 C 703
C
Sbjct: 511 C 511
Score = 101 bits (251), Expect = 7e-21
Identities = 69/241 (28%), Positives = 94/241 (39%), Gaps = 23/241 (9%)
Query: 1428 WEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPA-- 1485
W G+WS CSA CG G R + + + +C +P A CN+ CP
Sbjct: 281 WSHGSWSDCSAECG--GGHQSRLVFCTIDHEAYPDHMCQRQPRP-ADRRSCNLHPCPETK 337
Query: 1486 RWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAP-KDRPLGRKPCFGHPC 1544
RW W+ CS SCG G SR V C + G + V CA +P + C C
Sbjct: 338 RWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC 397
Query: 1545 VQW--EPGNRCPGRCMGRAVRMQQRHTACQHNSSD----SNCDDRKRPTLRRNCTSGAC- 1597
W EP C C V +++R C+ + C RP L C C
Sbjct: 398 AAWSPEPWGECSVSC---GVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCP 454
Query: 1598 ---DVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPS 1654
D WH G W C+ +C G + R+V C + P + +Q KP+ C
Sbjct: 455 LLSDQAWHVGTWGLCSKSCSSGTRRRQVIC----AIGPPSHCGSLQHSKPVDVEPCNTQP 510
Query: 1655 C 1655
C
Sbjct: 511 C 511
Score = 93.2 bits (230), Expect = 2e-18
Identities = 60/187 (32%), Positives = 89/187 (47%), Gaps = 15/187 (8%)
Query: 707 WHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEEC-RDEKPHALQACNQFDCPPG--W 763
W GSW CSA CG G Q+R V+C E P C R +P ++CN CP W
Sbjct: 281 WSHGSWSDCSAECGGGHQSRLVFCTIDHEA-YPDHMCQRQPRPADRRSCNLHPCPETKRW 339
Query: 764 HIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLN--LSDELCQG--PKASSHKSCARTDC 819
W CS +CGGG+Q+R V C + +DG+ + + + C G K + ++C C
Sbjct: 340 KAGPWAPCSASCGGGSQSRSVYC--ISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC 397
Query: 820 PPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQMPE 879
+ W +CSVSCGVG+++R C+ +G + + D P PL C +
Sbjct: 398 AAW-SPEPWGECSVSCGVGVRKRSVTCR--GERGSLLHTAACSLEDRP--PLTEPCVHED 452
Query: 880 CSKIKSE 886
C + +
Sbjct: 453 CPLLSDQ 459
Score = 53.9 bits (128), Expect = 1e-06
Identities = 34/90 (37%), Positives = 40/90 (44%), Gaps = 10/90 (11%)
Query: 1543 PCVQWEPGN--RCPGRCMGRAVRMQQRHTAC--QHNS-SDSNCDDRKRPTLRRNCTSGAC 1597
P W G+ C C G Q R C H + D C + RP RR+C C
Sbjct: 277 PGFSWSHGSWSDCSAECGGGH---QSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPC 333
Query: 1598 DVC--WHTGPWKPCTAACGRGFQSRKVDCI 1625
W GPW PC+A+CG G QSR V CI
Sbjct: 334 PETKRWKAGPWAPCSASCGGGSQSRSVYCI 363
Score = 46.2 bits (108), Expect = 3e-04
Identities = 25/89 (28%), Positives = 46/89 (51%), Gaps = 11/89 (12%)
Query: 1308 IVEAALGANVTIRCPVKGVPQPNITWLKRGGSLSG-NVSLLFNGSLLLQNVSLENEGTYV 1366
+V+A+ G + + C +G P P I W + G +S L +GSL++ V++E+ G Y
Sbjct: 1025 VVDASPGQRIRMTCRAEGFPPPAIEWQRDGQPVSSPRHQLQPDGSLVISRVAVEDGGFYT 1084
Query: 1367 CIATNALGKAVATSVLHLLERRWPESRIV 1395
C+A N + ++RW + R++
Sbjct: 1085 CVAFNGQDR----------DQRWVQLRVL 1103
Score = 45.1 bits (105), Expect = 6e-04
Identities = 32/102 (31%), Positives = 49/102 (48%), Gaps = 5/102 (4%)
Query: 930 VIIKCPVRRFQKSLIQWEKDGRCLQNSKRLGITKSGSLKIHGLAAPDIGVYRCIA---GS 986
V + C +S W+KDG+ + +S R + GSL IH L A D G Y C + G
Sbjct: 900 VRLSCSDDTAPESQAAWQKDGQPI-SSDRHRLQFDGSLIIHPLQAEDAGTYSCGSTRPGR 958
Query: 987 AQETVVLKLIGTDNRLIARPAL-REPMREYPGMDHSEANSLG 1027
+ + L++IG D +++ L R P P D +A + G
Sbjct: 959 DSQKIQLRIIGGDMAVLSEAELSRFPQPRDPAQDFGQAGAAG 1000
Score = 43.1 bits (100), Expect = 0.002
Identities = 25/71 (35%), Positives = 38/71 (53%), Gaps = 1/71 (1%)
Query: 1301 LSVVVGGIVEAALGANVTIRCPVKGVPQPNITWLKRGGSLSGN-VSLLFNGSLLLQNVSL 1359
L+ V +V+AALG V + C P+ W K G +S + L F+GSL++ +
Sbjct: 884 LAGVEPSLVQAALGQLVRLSCSDDTAPESQAAWQKDGQPISSDRHRLQFDGSLIIHPLQA 943
Query: 1360 ENEGTYVCIAT 1370
E+ GTY C +T
Sbjct: 944 EDAGTYSCGST 954
Score = 38.5 bits (88), Expect = 0.056
Identities = 23/76 (30%), Positives = 39/76 (51%), Gaps = 5/76 (6%)
Query: 926 PNTSVIIKCPVRRFQKSLIQWEKDGRCLQNSKRLGITKSGSLKIHGLAAPDIGVYRCIAG 985
P + + C F I+W++DG+ + +S R + GSL I +A D G Y C+A
Sbjct: 1030 PGQRIRMTCRAEGFPPPAIEWQRDGQPV-SSPRHQLQPDGSLVISRVAVEDGGFYTCVAF 1088
Query: 986 SAQET----VVLKLIG 997
+ Q+ V L+++G
Sbjct: 1089 NGQDRDQRWVQLRVLG 1104
Score = 38.1 bits (87), Expect = 0.073
Identities = 31/130 (23%), Positives = 47/130 (36%), Gaps = 26/130 (20%)
Query: 1490 SVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSP----RACAPKDRPLGRKPCFGHPCV 1545
S WS CS +CG G R+ C + +G V P R+C + P G + C
Sbjct: 33 SQWSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPARSHRSCRTESCPDGARDFRAEQCA 92
Query: 1546 Q------------WEP----GNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLR 1589
+ W P N+C C+ + +H + + C+ KR
Sbjct: 93 EFDGAEFQGRRYRWLPYYSAPNKCELNCIPKGENFYYKHREAVVDGTP--CEPGKRDV-- 148
Query: 1590 RNCTSGACDV 1599
C G+C V
Sbjct: 149 --CVDGSCRV 156
Score = 32.7 bits (73), Expect = 3.1
Identities = 34/146 (23%), Positives = 53/146 (36%), Gaps = 21/146 (14%)
Query: 1227 WTKDGTLLQPSVKIILDGTGKIQIQNPTRKEQGIYECSVANHLGSDVESSSVLYAEAPVI 1286
W +DG + S + L G + I ++ G Y C N D + I
Sbjct: 1050 WQRDGQPVS-SPRHQLQPDGSLVISRVAVEDGGFYTCVAFNGQDRDQRWVQLRVLGELTI 1108
Query: 1287 LSVERNITKPEHNHLSVVVGGIVEAALGANVTIRCPVKGVPQPNITWLKRGGSLSGN--- 1343
+ +T PE G + C V G NI W + G + +
Sbjct: 1109 SGLPPTVTVPE----------------GDTARLLCVVAG-ESVNIRWSRNGLPVQADGHR 1151
Query: 1344 VSLLFNGSLLLQNVSLENEGTYVCIA 1369
V +G+LL+ N+ +EG+Y C A
Sbjct: 1152 VHQSPDGTLLIYNLRARDEGSYTCSA 1177
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1 motif,
17 preproprotein [Homo sapiens]
Length = 1095
Score = 247 bits (631), Expect = 6e-65
Identities = 171/609 (28%), Positives = 244/609 (40%), Gaps = 125/609 (20%)
Query: 72 EDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPP 125
E DG+W WG WS CSRTCG GA + R+C G +C G ++ + C N CP
Sbjct: 540 EHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPK 599
Query: 126 DAEDFRAQQCSAYNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLDGTR 185
FR QQC A++ + + +D PC L C G+ + +A +VLDGT
Sbjct: 600 GLPSFRDQQCQAHDRLSPKKKGLLTAVVVDDK--PCELYCSPLGKESPLLVADRVLDGTP 657
Query: 186 CNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKREE 245
C D+C+ G CQ +GCD +GS AKED CGVC+GDG TC LV+G SH
Sbjct: 658 CGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDF-SH-------- 708
Query: 246 NVIAVPLGSRSVRITVKGPAHLFIESKTLQGSKGEHSFNSPGVFLVENTTVEFQRGSERQ 305
+R + G + + PG F + TTV + R +
Sbjct: 709 --------ARGTALKDSGKGSI----------NSDWKIELPGEFQIAGTTVRYVRRGLWE 750
Query: 306 TFKIPGPLMADFIFKTRYTAAKDSVVQFFFYQPISHQ----------------WRQTDFF 349
GP +D + + + P++ W + +
Sbjct: 751 KISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQSEPEKPQDSLFIWTHSGWE 810
Query: 350 PCTVTCGGGYQLNSAECVDI--RLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGF 407
C+V CGGG + C I + +V D C P+ +P+P+++ C++ PC S
Sbjct: 811 GCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDC---PQASRPEPQVRRCNLHPCQS---- 863
Query: 408 KEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPK 467
RW PW+ CS +C G Q R CV + +G + C P+
Sbjct: 864 -------------RWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCP-GPR 909
Query: 468 PKVMQTCNLFDCPK-WIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKE 526
P +Q+C DC W A EWSQC+ +CG+G+ R V C N +G+ C+ + +E
Sbjct: 910 PAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGK----CDASTRPRAEE 965
Query: 527 ECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQV 586
C CY+ K WS CS+TCG G+Q
Sbjct: 966 ACEDYSGCYEWKTGD-------------------------------WSTCSSTCGKGLQS 994
Query: 587 REVKCRVLLTFTQTETELPEEECEGPKLPTE-RPCLLEACDE--------SPASRELDIP 637
R V+C +T EC P R C E C++ SP L
Sbjct: 995 RVVQCMHKVTGRH------GSECPALSKPAPYRQCYQEVCNDRINANTITSPRLAALTYK 1048
Query: 638 LPEDSETTY 646
D T Y
Sbjct: 1049 CTRDQWTVY 1057
Score = 150 bits (378), Expect = 1e-35
Identities = 100/319 (31%), Positives = 135/319 (42%), Gaps = 41/319 (12%)
Query: 1400 HKKYILQATNTRTNSNDPTGEPPPQEPF-WEPGNWSHCSATCGHLGAR--IQRPQCVMAN 1456
H +Y + T N ++P E P F W W CS CG R + + V
Sbjct: 777 HYEYTVPVNRTAENQSEP--EKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKT 834
Query: 1457 GQEVSEALCDHLQKPLAGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKAN 1516
V+++ C +P CN+ C +RW WS CS +C +G+ R+VTC N
Sbjct: 835 TTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQN 894
Query: 1517 GTVQVVSPRACAPKDRPLGRKPCFGHPCVQ-WEPG--NRCPGRCMGRAVRMQQRHTACQH 1573
GT P C P RP + C G C+ WE ++C C G+ V +R AC
Sbjct: 895 GTHVATRPLYC-PGPRPAAVQSCEGQDCLSIWEASEWSQCSASC-GKGV--WKRTVAC-- 948
Query: 1574 NSSDSNCDDRKRPTLRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPV 1633
+S CD RP C + W TG W C++ CG+G QSR V C+H V
Sbjct: 949 TNSQGKCDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMH-----KV 1003
Query: 1634 AKRH---CVQKKKPISWRHCLGPSC-DR----------------DCT--DTTHYCMFVKH 1671
RH C KP +R C C DR CT T YC ++
Sbjct: 1004 TGRHGSECPALSKPAPYRQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTVYCRVIRE 1063
Query: 1672 LNLCSLDRYKQRCCQSCQE 1690
NLC R+ QRCCQ+C++
Sbjct: 1064 KNLCQDMRWYQRCCQTCRD 1082
Score = 138 bits (347), Expect = 5e-32
Identities = 77/216 (35%), Positives = 99/216 (45%), Gaps = 21/216 (9%)
Query: 639 PEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQT--VNDSLCDMVHRPPAMSQ 696
P+DS + W ++G+ C+ C GG + I C I + T VNDS C RP +
Sbjct: 797 PQDS--LFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVR 854
Query: 697 ACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHP----GETPAPPEECRDEKPHALQ 752
CN PC RW G W PCSATC G Q R+V C++ P C +P A+Q
Sbjct: 855 RCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQ 914
Query: 753 ACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTC--RQLLTDGSFLNLSDELCQGPKASS 810
+C DC W EW QCS +CG G R V C Q D S ++E C+
Sbjct: 915 SCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTRPRAEEACE-----D 969
Query: 811 HKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVC 846
+ C GDWS CS +CG G+Q R C
Sbjct: 970 YSGCY------EWKTGDWSTCSSTCGKGLQSRVVQC 999
Score = 90.1 bits (222), Expect = 2e-17
Identities = 111/425 (26%), Positives = 160/425 (37%), Gaps = 47/425 (11%)
Query: 487 WSQCTVTCGRGLRYRVVLCINHR----GEHVGGCNPQLKLHIKEECVIPIPCYK------ 536
WS C+ TCG G R+R C N G H G + + + C +P ++
Sbjct: 552 WSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQA 611
Query: 537 -----PKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREV-- 589
PK+K + A + K EL + + E P + + T CGP V
Sbjct: 612 HDRLSPKKKGLLTAVVVDDKPC-ELYCSPLGKESPLLVADR-VLDGTPCGPYETDLCVHG 669
Query: 590 KCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDW- 648
KC+ + + E+ C G + C L D S A R + DW
Sbjct: 670 KCQKIGCDGIIGSAAKEDRC-GVCSGDGKTCHLVKGDFSHA-RGTALKDSGKGSINSDWK 727
Query: 649 -EYAGFTPCTATCVG----GHQEAIA------VCLHIQTQQTVN-DSLCDMVHRPPAMSQ 696
E G T V G E I+ + LH+ + D + P
Sbjct: 728 IELPGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRT 787
Query: 697 ACN-TEPCPPR-----WHVGSWGPCSATCGVGIQTRDVYC---LHPGETPAPPEEC-RDE 746
A N +EP P+ W W CS CG G + V C ++ T +C +
Sbjct: 788 AENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQAS 847
Query: 747 KPHA-LQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQG 805
+P ++ CN C W W CS TC G Q+R VTC L +G+ + C G
Sbjct: 848 RPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPG 907
Query: 806 PKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAK--GRRIPLSEMMC 863
P+ ++ +SC DC +WS+CS SCG G+ +R C K P +E C
Sbjct: 908 PRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTRPRAEEAC 967
Query: 864 RDLPG 868
D G
Sbjct: 968 EDYSG 972
Score = 85.5 bits (210), Expect = 4e-16
Identities = 74/279 (26%), Positives = 102/279 (36%), Gaps = 55/279 (19%)
Query: 482 WIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKS 541
W W C+V CG G R +V C N L +C P+
Sbjct: 804 WTHSGWEGCSVQCGGGERRTIVSCTRI-------VNKTTTLVNDSDC--------PQASR 848
Query: 542 PVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTE 601
P ++ + + ++ PWS CS TC G Q REV C L T
Sbjct: 849 P----------EPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQ-NGTH 897
Query: 602 TELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCV 661
C GP RP +++C E + WE + ++ C+A+C
Sbjct: 898 VATRPLYCPGP-----RPAAVQSC--------------EGQDCLSIWEASEWSQCSASCG 938
Query: 662 GGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGV 721
G + C + Q + CD RP A +AC W G W CS+TCG
Sbjct: 939 KGVWKRTVACTNSQGK-------CDASTRPRA-EEACEDYSGCYEWKTGDWSTCSSTCGK 990
Query: 722 GIQTRDVYCLHPGETPAPPEECRD-EKPHALQACNQFDC 759
G+Q+R V C+H T EC KP + C Q C
Sbjct: 991 GLQSRVVQCMHK-VTGRHGSECPALSKPAPYRQCYQEVC 1028
Score = 37.4 bits (85), Expect = 0.12
Identities = 21/62 (33%), Positives = 25/62 (40%), Gaps = 2/62 (3%)
Query: 710 GSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQ 769
G+W CS TCG G + R C +P P HA+ C CP G Q
Sbjct: 550 GAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAV--CENLPCPKGLPSFRDQ 607
Query: 770 QC 771
QC
Sbjct: 608 QC 609
Score = 34.7 bits (78), Expect = 0.81
Identities = 39/148 (26%), Positives = 52/148 (35%), Gaps = 40/148 (27%)
Query: 1428 WEP-GNWSHCSATCGHLGARIQRPQC---------VMANGQEVSEALCDHLQKPLAGFEP 1477
W P G WS CS TCG GAR ++ +C G V A+C++L P G
Sbjct: 546 WSPWGAWSMCSRTCG-TGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCP-KGLPS 603
Query: 1478 CNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRK 1537
+ C A H R + K T VV + C PLG++
Sbjct: 604 FRDQQCQA------------------HDR--LSPKKKGLLTAVVVDDKPCELYCSPLGKE 643
Query: 1538 PCF--------GHPCVQWEPGNRCPGRC 1557
G PC +E G+C
Sbjct: 644 SPLLVADRVLDGTPCGPYETDLCVHGKC 671
Score = 33.5 bits (75), Expect = 1.8
Identities = 39/155 (25%), Positives = 55/155 (35%), Gaps = 27/155 (17%)
Query: 761 PGWHIEEWQQCSRTCGGGTQNRR----VTCRQLLT----DGSFLNLSDELCQGPKASSHK 812
PG H +QC G R + C L D S D G + + K
Sbjct: 466 PGMHYSANEQCQILFGMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADK 525
Query: 813 SCARTDC------PPHL-----AVGDWSKCSVSCGVGIQRRKQVCQR--LAAKGRRIP-- 857
C +C P H+ G WS CS +CG G + R++ C G P
Sbjct: 526 WCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGA 585
Query: 858 -LSEMMCRDLP---GLPLVRSCQMPECSKIKSEMK 888
+ +C +LP GLP R Q ++ + K
Sbjct: 586 SVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKK 620
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 245 bits (626), Expect = 2e-64
Identities = 219/809 (27%), Positives = 331/809 (40%), Gaps = 114/809 (14%)
Query: 76 GNWDAWGDWSDCSRTCGGGASYSLRRC------LTGRNCEGQNIRYKTCSNHDCPPDAED 129
G W +WG S CSR+CGGG R+C GR C G +++ + C+ C +
Sbjct: 354 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLE 413
Query: 130 FRAQQCSAYNDVQYQGH-----YYEW---LPRYNDPAAPCALKCHAQGQNLVVELAPKVL 181
F +QQC+ + + +Y W +P ++ A C C A G++ +++ L
Sbjct: 414 FMSQQCARTDGQPLRSSPGGASFYHWGAAVP-HSQGDALCRHMCRAIGESFIMKRGDSFL 472
Query: 182 DGTRC------NTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTC-----RLV 230
DGTRC +L +C+SG C+ GCD ++ S D C VC GD STC
Sbjct: 473 DGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFT 532
Query: 231 RGQSKSHVSPEKREENVIAVPLGSRSVRITVKGPAHLFIE--SKTLQGSKGEHSFNSPGV 288
G+++ +V+ N+ +V + + T HL + + + K S N+
Sbjct: 533 AGRAREYVTFLTVTPNLTSVYIANHRPLFT-----HLAVRIGGRYVVAGKMSISPNTTYP 587
Query: 289 FLVENTTVEFQ------RGSERQTFKIPGPLM--ADFIFKTRYTAAKDSV----VQFFFY 336
L+E+ VE++ R + +I GPL AD RY ++ + F ++
Sbjct: 588 SLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYF 647
Query: 337 QPISHQ---WRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKL 393
QP Q W PC+V+CG G + + C+D K +V C + +P
Sbjct: 648 QPKPRQAWVWAAVR-GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQ---GSQQPPAWP 703
Query: 394 KECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGE 453
+ C ++PCP P W + CS SCGGG++ R CVE G
Sbjct: 704 EACVLEPCP-----------------PYWAVGDFGPCSASCGGGLRERPVRCVE--AQGS 744
Query: 454 ILQ-VEEWKCMY-APKPKV-MQTCNLFDCP-KWIAMEWSQCTVTCGRGLRYRVVLCINHR 509
+L+ + +C A +P V ++TCN CP +W E S CT G GL C+
Sbjct: 745 LLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCV-PG 803
Query: 510 GEHVGGCNPQLKLHIKEECVIPIPCYK---PKEKSPVEAKLPWLKQAQELEETRIATEEP 566
+ + + + E+ P PC P ++A K R +
Sbjct: 804 ADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAA 863
Query: 567 TFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACD 626
+CS +CG G+ ++ R L + + EE C P R E C
Sbjct: 864 HVWTPAAGSCSVSCGRGL----MELRFLCMDSALRVPVQEELCGLASKPGSR---REVCQ 916
Query: 627 ESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHI----QTQQTVND 682
P W+Y C+ +C G I C ++ + D
Sbjct: 917 AVPCPAR--------------WQYK-LAACSVSCGRGVVRRILYCARAHGEDDGEEILLD 961
Query: 683 SLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYC--LHPGETPAPP 740
+ C + RP +AC+ EPCPPRW V S GPCSA+CG+G R V C L G+
Sbjct: 962 TQCQGLPRPEP-QEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVD 1020
Query: 741 EECRDE--KPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNL 798
E +P A C DC WH+ W +CS +CG G Q RR TC L + +
Sbjct: 1021 EAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTC---LGPQAQAPV 1077
Query: 799 SDELCQG-PKASSHKSCARTDCPPHLAVG 826
+ CQ PK + + C C A G
Sbjct: 1078 PADFCQHLPKPVTVRGCWAGPCVGQGACG 1106
Score = 171 bits (432), Expect = 7e-42
Identities = 139/503 (27%), Positives = 206/503 (40%), Gaps = 82/503 (16%)
Query: 413 YDHFQPLPRWEHNPWTA----CSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKP 468
+ +FQP PR + W A CSVSCG G++ ++ C++++ VE +C + +P
Sbjct: 644 FTYFQPKPR-QAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKE---LVETVQCQGSQQP 699
Query: 469 KVM-QTCNLFDCPK-WIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKE 526
+ C L CP W ++ C+ +CG GLR R V C+ +G +
Sbjct: 700 PAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLL------------- 746
Query: 527 ECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPW-----SACSTTCG 581
K P + + A LE T P P W S+C++ G
Sbjct: 747 -----------KTLPPARCRAGAQQPAVALE-----TCNPQPCPARWEVSEPSSCTSAGG 790
Query: 582 PGVQVREVKCRVLLTFTQTETELPEEECEGP-----KLPTERPCLLEAC-------DESP 629
G+ + C L EGP KLP PC+ +C D +
Sbjct: 791 AGLALENETC------VPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATS 844
Query: 630 ASRELDIP---LPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCD 686
A + P + ++ + W A + C+ +C G E +C+ + V + LC
Sbjct: 845 AGEKAPSPWGSIRTGAQAAHVWTPAAGS-CSVSCGRGLMELRFLCMDSALRVPVQEELCG 903
Query: 687 MVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHP-----GETPAPPE 741
+ +P + + C PCP RW CS +CG G+ R +YC GE
Sbjct: 904 LASKPGSRREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDT 962
Query: 742 ECRD-EKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSD 800
+C+ +P +AC+ CPP W + CS +CG GT R V C QL G + + +
Sbjct: 963 QCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQL-DQGQDVEVDE 1021
Query: 801 ELCQG---PKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIP 857
C P+AS C DC VG W +CSVSCG GIQRR+ C A+ P
Sbjct: 1022 AACAALVRPEASV--PCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQA---P 1076
Query: 858 LSEMMCRDLPGLPLVRSCQMPEC 880
+ C+ LP VR C C
Sbjct: 1077 VPADFCQHLPKPVTVRGCWAGPC 1099
Score = 101 bits (251), Expect = 7e-21
Identities = 113/477 (23%), Positives = 161/477 (33%), Gaps = 145/477 (30%)
Query: 337 QPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIR--LKRVVPDHYCHYYPENVKPKPKLK 394
+P W DF PC+ +CGGG + CV+ + L + +P C + +P L+
Sbjct: 709 EPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQ--QPAVALE 766
Query: 395 ECSMDPC----------------------------PSSDGFKEIMP-----YDHFQPLPR 421
C+ PC P +DG + + D P P
Sbjct: 767 TCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPE 826
Query: 422 ----------WEH-----------NPWTA-----------------CSVSCGGGIQRRSF 443
W H +PW + CSVSCG G+ F
Sbjct: 827 PCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRF 886
Query: 444 VCVEESMHGEILQVEEWKCMYAPKP-KVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRV 502
+C++ ++ + V+E C A KP + C CP + + C+V+CGRG+ R+
Sbjct: 887 LCMDSALR---VPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRI 943
Query: 503 VLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIA 562
+ C GE G EE ++ C P EA
Sbjct: 944 LYCARAHGEDDG-----------EEILLDTQCQGLPRPEPQEA----------------C 976
Query: 563 TEEPTFIPEPWSA-----CSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLP-T 616
+ EP P W CS +CG G R V C V L Q + E+ E C P
Sbjct: 977 SLEP--CPPRWKVMSLGPCSASCGLGTARRSVAC-VQLDQGQ-DVEVDEAACAALVRPEA 1032
Query: 617 ERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQT 676
PCL+ C TY W + C+ +C G Q CL Q
Sbjct: 1033 SVPCLIADC-------------------TYRWHVGTWMECSVSCGDGIQRRRDTCLGPQA 1073
Query: 677 QQTVNDSLCDMVHRP---------PAMSQ-ACNTEPCPPRWHVGSWGPCSATCGVGI 723
Q V C + +P P + Q AC + P + GP A C V I
Sbjct: 1074 QAPVPADFCQHLPKPVTVRGCWAGPCVGQGACGRQHLEPTGTIDMRGPGQADCAVAI 1130
Score = 93.6 bits (231), Expect = 1e-18
Identities = 70/237 (29%), Positives = 95/237 (40%), Gaps = 12/237 (5%)
Query: 1428 WEPGNWSHCSATCGHLGARIQRPQCV-MANGQEVSEALCDHLQKPLAGFEPCNIRDCPAR 1486
W P S CS +CG G R C+ A V E LC KP + E C CPAR
Sbjct: 866 WTPAAGS-CSVSCGR-GLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPAR 923
Query: 1487 WFTSVWSQCSVSCGEGYHSRQVTCKRTKANGT-VQVVSPRACAPKDRPLGRKPCFGHPCV 1545
W + + CSVSCG G R + C R +++ C RP ++ C PC
Sbjct: 924 WQYKL-AACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCP 982
Query: 1546 -QWEPGNR--CPGRC----MGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGACD 1598
+W+ + C C R+V Q ++ C RP C C
Sbjct: 983 PRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCT 1042
Query: 1599 VCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSC 1655
WH G W C+ +CG G Q R+ C+ ++ PV C KP++ R C C
Sbjct: 1043 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1099
Score = 68.6 bits (166), Expect = 5e-11
Identities = 64/238 (26%), Positives = 92/238 (38%), Gaps = 32/238 (13%)
Query: 1423 PQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANG---QEVSEALCDH-LQKPLAGFEPC 1478
P P+W G++ CSA+CG G R + +CV A G + + A C Q+P E C
Sbjct: 710 PCPPYWAVGDFGPCSASCGG-GLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETC 768
Query: 1479 NIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKP 1538
N + CPARW S S C+ + G G TC A+G V+ + ++ +P
Sbjct: 769 NPQPCPARWEVSEPSSCTSAGGAGLALENETCV-PGADGLEAPVTEGPGSVDEKLPAPEP 827
Query: 1539 CFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGACD 1598
C G C PG D+ K P+ + +GA
Sbjct: 828 CVGMSC---PPG----------------------WGHLDATSAGEKAPSPWGSIRTGAQA 862
Query: 1599 VCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRH-CLGPSC 1655
T C+ +CGRG + C+ + PV + C KP S R C C
Sbjct: 863 AHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPC 920
Score = 62.0 bits (149), Expect = 5e-09
Identities = 75/310 (24%), Positives = 103/310 (33%), Gaps = 52/310 (16%)
Query: 1393 RIVFLQGHKKYILQATNTRTNSNDP-----TGEPPPQEPFWEPGNWSHCSATCGHLGARI 1447
R V QG L R + P T P P WE S C++ G G +
Sbjct: 737 RCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSA-GGAGLAL 795
Query: 1448 QRPQCVM-ANGQE--VSEALCDHLQKPLAGFEPCNIRDCPARW----------------- 1487
+ CV A+G E V+E + + L EPC CP W
Sbjct: 796 ENETCVPGADGLEAPVTEGP-GSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWG 854
Query: 1488 -----------FTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGR 1536
+T CSVSCG G + C + VQ C +P R
Sbjct: 855 SIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQ---EELCGLASKPGSR 911
Query: 1537 KP-CFGHPC-VQWEPGNRCPGRCMGRAVRMQQRHTACQHNSS-------DSNCDDRKRPT 1587
+ C PC +W+ GR V + + A H D+ C RP
Sbjct: 912 REVCQAVPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPE 971
Query: 1588 LRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVA--KRHCVQKKKPI 1645
+ C+ C W PC+A+CG G R V C+ + V + C +P
Sbjct: 972 PQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPE 1031
Query: 1646 SWRHCLGPSC 1655
+ CL C
Sbjct: 1032 ASVPCLIADC 1041
Score = 36.6 bits (83), Expect = 0.21
Identities = 14/43 (32%), Positives = 20/43 (46%)
Query: 1586 PTLRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTR 1628
P C C W G + PC+A+CG G + R V C+ +
Sbjct: 700 PAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQ 742
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 245 bits (626), Expect = 2e-64
Identities = 219/809 (27%), Positives = 331/809 (40%), Gaps = 114/809 (14%)
Query: 76 GNWDAWGDWSDCSRTCGGGASYSLRRC------LTGRNCEGQNIRYKTCSNHDCPPDAED 129
G W +WG S CSR+CGGG R+C GR C G +++ + C+ C +
Sbjct: 385 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLE 444
Query: 130 FRAQQCSAYNDVQYQGH-----YYEW---LPRYNDPAAPCALKCHAQGQNLVVELAPKVL 181
F +QQC+ + + +Y W +P ++ A C C A G++ +++ L
Sbjct: 445 FMSQQCARTDGQPLRSSPGGASFYHWGAAVP-HSQGDALCRHMCRAIGESFIMKRGDSFL 503
Query: 182 DGTRC------NTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTC-----RLV 230
DGTRC +L +C+SG C+ GCD ++ S D C VC GD STC
Sbjct: 504 DGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFT 563
Query: 231 RGQSKSHVSPEKREENVIAVPLGSRSVRITVKGPAHLFIE--SKTLQGSKGEHSFNSPGV 288
G+++ +V+ N+ +V + + T HL + + + K S N+
Sbjct: 564 AGRAREYVTFLTVTPNLTSVYIANHRPLFT-----HLAVRIGGRYVVAGKMSISPNTTYP 618
Query: 289 FLVENTTVEFQ------RGSERQTFKIPGPLM--ADFIFKTRYTAAKDSV----VQFFFY 336
L+E+ VE++ R + +I GPL AD RY ++ + F ++
Sbjct: 619 SLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYF 678
Query: 337 QPISHQ---WRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKL 393
QP Q W PC+V+CG G + + C+D K +V C + +P
Sbjct: 679 QPKPRQAWVWAAVR-GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQ---GSQQPPAWP 734
Query: 394 KECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGE 453
+ C ++PCP P W + CS SCGGG++ R CVE G
Sbjct: 735 EACVLEPCP-----------------PYWAVGDFGPCSASCGGGLRERPVRCVE--AQGS 775
Query: 454 ILQ-VEEWKCMY-APKPKV-MQTCNLFDCP-KWIAMEWSQCTVTCGRGLRYRVVLCINHR 509
+L+ + +C A +P V ++TCN CP +W E S CT G GL C+
Sbjct: 776 LLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCV-PG 834
Query: 510 GEHVGGCNPQLKLHIKEECVIPIPCYK---PKEKSPVEAKLPWLKQAQELEETRIATEEP 566
+ + + + E+ P PC P ++A K R +
Sbjct: 835 ADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAA 894
Query: 567 TFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACD 626
+CS +CG G+ ++ R L + + EE C P R E C
Sbjct: 895 HVWTPAAGSCSVSCGRGL----MELRFLCMDSALRVPVQEELCGLASKPGSR---REVCQ 947
Query: 627 ESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHI----QTQQTVND 682
P W+Y C+ +C G I C ++ + D
Sbjct: 948 AVPCPAR--------------WQYK-LAACSVSCGRGVVRRILYCARAHGEDDGEEILLD 992
Query: 683 SLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYC--LHPGETPAPP 740
+ C + RP +AC+ EPCPPRW V S GPCSA+CG+G R V C L G+
Sbjct: 993 TQCQGLPRPEP-QEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVD 1051
Query: 741 EECRDE--KPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNL 798
E +P A C DC WH+ W +CS +CG G Q RR TC L + +
Sbjct: 1052 EAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTC---LGPQAQAPV 1108
Query: 799 SDELCQG-PKASSHKSCARTDCPPHLAVG 826
+ CQ PK + + C C A G
Sbjct: 1109 PADFCQHLPKPVTVRGCWAGPCVGQGACG 1137
Score = 171 bits (432), Expect = 7e-42
Identities = 139/503 (27%), Positives = 206/503 (40%), Gaps = 82/503 (16%)
Query: 413 YDHFQPLPRWEHNPWTA----CSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKP 468
+ +FQP PR + W A CSVSCG G++ ++ C++++ VE +C + +P
Sbjct: 675 FTYFQPKPR-QAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKE---LVETVQCQGSQQP 730
Query: 469 KVM-QTCNLFDCPK-WIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKE 526
+ C L CP W ++ C+ +CG GLR R V C+ +G +
Sbjct: 731 PAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLL------------- 777
Query: 527 ECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPW-----SACSTTCG 581
K P + + A LE T P P W S+C++ G
Sbjct: 778 -----------KTLPPARCRAGAQQPAVALE-----TCNPQPCPARWEVSEPSSCTSAGG 821
Query: 582 PGVQVREVKCRVLLTFTQTETELPEEECEGP-----KLPTERPCLLEAC-------DESP 629
G+ + C L EGP KLP PC+ +C D +
Sbjct: 822 AGLALENETC------VPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATS 875
Query: 630 ASRELDIP---LPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCD 686
A + P + ++ + W A + C+ +C G E +C+ + V + LC
Sbjct: 876 AGEKAPSPWGSIRTGAQAAHVWTPAAGS-CSVSCGRGLMELRFLCMDSALRVPVQEELCG 934
Query: 687 MVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHP-----GETPAPPE 741
+ +P + + C PCP RW CS +CG G+ R +YC GE
Sbjct: 935 LASKPGSRREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDT 993
Query: 742 ECRD-EKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSD 800
+C+ +P +AC+ CPP W + CS +CG GT R V C QL G + + +
Sbjct: 994 QCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQL-DQGQDVEVDE 1052
Query: 801 ELCQG---PKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIP 857
C P+AS C DC VG W +CSVSCG GIQRR+ C A+ P
Sbjct: 1053 AACAALVRPEASV--PCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQA---P 1107
Query: 858 LSEMMCRDLPGLPLVRSCQMPEC 880
+ C+ LP VR C C
Sbjct: 1108 VPADFCQHLPKPVTVRGCWAGPC 1130
Score = 101 bits (251), Expect = 7e-21
Identities = 113/477 (23%), Positives = 161/477 (33%), Gaps = 145/477 (30%)
Query: 337 QPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIR--LKRVVPDHYCHYYPENVKPKPKLK 394
+P W DF PC+ +CGGG + CV+ + L + +P C + +P L+
Sbjct: 740 EPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQ--QPAVALE 797
Query: 395 ECSMDPC----------------------------PSSDGFKEIMP-----YDHFQPLPR 421
C+ PC P +DG + + D P P
Sbjct: 798 TCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPE 857
Query: 422 ----------WEH-----------NPWTA-----------------CSVSCGGGIQRRSF 443
W H +PW + CSVSCG G+ F
Sbjct: 858 PCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRF 917
Query: 444 VCVEESMHGEILQVEEWKCMYAPKP-KVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRV 502
+C++ ++ + V+E C A KP + C CP + + C+V+CGRG+ R+
Sbjct: 918 LCMDSALR---VPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRI 974
Query: 503 VLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIA 562
+ C GE G EE ++ C P EA
Sbjct: 975 LYCARAHGEDDG-----------EEILLDTQCQGLPRPEPQEA----------------C 1007
Query: 563 TEEPTFIPEPWSA-----CSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLP-T 616
+ EP P W CS +CG G R V C V L Q + E+ E C P
Sbjct: 1008 SLEP--CPPRWKVMSLGPCSASCGLGTARRSVAC-VQLDQGQ-DVEVDEAACAALVRPEA 1063
Query: 617 ERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQT 676
PCL+ C TY W + C+ +C G Q CL Q
Sbjct: 1064 SVPCLIADC-------------------TYRWHVGTWMECSVSCGDGIQRRRDTCLGPQA 1104
Query: 677 QQTVNDSLCDMVHRP---------PAMSQ-ACNTEPCPPRWHVGSWGPCSATCGVGI 723
Q V C + +P P + Q AC + P + GP A C V I
Sbjct: 1105 QAPVPADFCQHLPKPVTVRGCWAGPCVGQGACGRQHLEPTGTIDMRGPGQADCAVAI 1161
Score = 93.6 bits (231), Expect = 1e-18
Identities = 70/237 (29%), Positives = 95/237 (40%), Gaps = 12/237 (5%)
Query: 1428 WEPGNWSHCSATCGHLGARIQRPQCV-MANGQEVSEALCDHLQKPLAGFEPCNIRDCPAR 1486
W P S CS +CG G R C+ A V E LC KP + E C CPAR
Sbjct: 897 WTPAAGS-CSVSCGR-GLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPAR 954
Query: 1487 WFTSVWSQCSVSCGEGYHSRQVTCKRTKANGT-VQVVSPRACAPKDRPLGRKPCFGHPCV 1545
W + + CSVSCG G R + C R +++ C RP ++ C PC
Sbjct: 955 WQYKL-AACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCP 1013
Query: 1546 -QWEPGNR--CPGRC----MGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGACD 1598
+W+ + C C R+V Q ++ C RP C C
Sbjct: 1014 PRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCT 1073
Query: 1599 VCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSC 1655
WH G W C+ +CG G Q R+ C+ ++ PV C KP++ R C C
Sbjct: 1074 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 68.6 bits (166), Expect = 5e-11
Identities = 64/238 (26%), Positives = 92/238 (38%), Gaps = 32/238 (13%)
Query: 1423 PQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANG---QEVSEALCDH-LQKPLAGFEPC 1478
P P+W G++ CSA+CG G R + +CV A G + + A C Q+P E C
Sbjct: 741 PCPPYWAVGDFGPCSASCGG-GLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETC 799
Query: 1479 NIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKP 1538
N + CPARW S S C+ + G G TC A+G V+ + ++ +P
Sbjct: 800 NPQPCPARWEVSEPSSCTSAGGAGLALENETCV-PGADGLEAPVTEGPGSVDEKLPAPEP 858
Query: 1539 CFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGACD 1598
C G C PG D+ K P+ + +GA
Sbjct: 859 CVGMSC---PPG----------------------WGHLDATSAGEKAPSPWGSIRTGAQA 893
Query: 1599 VCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRH-CLGPSC 1655
T C+ +CGRG + C+ + PV + C KP S R C C
Sbjct: 894 AHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPC 951
Score = 62.0 bits (149), Expect = 5e-09
Identities = 75/310 (24%), Positives = 103/310 (33%), Gaps = 52/310 (16%)
Query: 1393 RIVFLQGHKKYILQATNTRTNSNDP-----TGEPPPQEPFWEPGNWSHCSATCGHLGARI 1447
R V QG L R + P T P P WE S C++ G G +
Sbjct: 768 RCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSA-GGAGLAL 826
Query: 1448 QRPQCVM-ANGQE--VSEALCDHLQKPLAGFEPCNIRDCPARW----------------- 1487
+ CV A+G E V+E + + L EPC CP W
Sbjct: 827 ENETCVPGADGLEAPVTEGP-GSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWG 885
Query: 1488 -----------FTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGR 1536
+T CSVSCG G + C + VQ C +P R
Sbjct: 886 SIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQ---EELCGLASKPGSR 942
Query: 1537 KP-CFGHPC-VQWEPGNRCPGRCMGRAVRMQQRHTACQHNSS-------DSNCDDRKRPT 1587
+ C PC +W+ GR V + + A H D+ C RP
Sbjct: 943 REVCQAVPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPE 1002
Query: 1588 LRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVA--KRHCVQKKKPI 1645
+ C+ C W PC+A+CG G R V C+ + V + C +P
Sbjct: 1003 PQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPE 1062
Query: 1646 SWRHCLGPSC 1655
+ CL C
Sbjct: 1063 ASVPCLIADC 1072
Score = 36.6 bits (83), Expect = 0.21
Identities = 14/43 (32%), Positives = 20/43 (46%)
Query: 1586 PTLRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTR 1628
P C C W G + PC+A+CG G + R V C+ +
Sbjct: 731 PAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQ 773
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 245 bits (625), Expect = 3e-64
Identities = 210/768 (27%), Positives = 317/768 (41%), Gaps = 110/768 (14%)
Query: 76 GNWDAWGDWSDCSRTCGGGASYSLRRC------LTGRNCEGQNIRYKTCSNHDCPPDAED 129
G W +WG S CSR+CGGG R+C GR C G +++ + C+ C +
Sbjct: 385 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLE 444
Query: 130 FRAQQCSAYNDVQYQGH-----YYEW---LPRYNDPAAPCALKCHAQGQNLVVELAPKVL 181
F +QQC+ + + +Y W +P ++ A C C A G++ +++ L
Sbjct: 445 FMSQQCARTDGQPLRSSPGGASFYHWGAAVP-HSQGDALCRHMCRAIGESFIMKRGDSFL 503
Query: 182 DGTRC------NTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTC-----RLV 230
DGTRC +L +C+SG C+ GCD ++ S D C VC GD STC
Sbjct: 504 DGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFT 563
Query: 231 RGQSKSHVSPEKREENVIAVPLGSRSVRITVKGPAHLFIE--SKTLQGSKGEHSFNSPGV 288
G+++ +V+ N+ +V + + T HL + + + K S N+
Sbjct: 564 AGRAREYVTFLTVTPNLTSVYIANHRPLFT-----HLAVRIGGRYVVAGKMSISPNTTYP 618
Query: 289 FLVENTTVEFQ------RGSERQTFKIPGPLM--ADFIFKTRYTAAKDSV----VQFFFY 336
L+E+ VE++ R + +I GPL AD RY ++ + F ++
Sbjct: 619 SLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYF 678
Query: 337 QPISHQ---WRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKL 393
QP Q W PC+V+CG G + + C+D K +V C + +P
Sbjct: 679 QPKPRQAWVWAAVR-GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQ---GSQQPPAWP 734
Query: 394 KECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGE 453
+ C ++PCP P W + CS SCGGG++ R CVE G
Sbjct: 735 EACVLEPCP-----------------PYWAVGDFGPCSASCGGGLRERPVRCVE--AQGS 775
Query: 454 ILQ-VEEWKCMY-APKPKV-MQTCNLFDCP-KWIAMEWSQCTVTCGRGLRYRVVLCINHR 509
+L+ + +C A +P V ++TCN CP +W E S CT G GL C+
Sbjct: 776 LLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCV-PG 834
Query: 510 GEHVGGCNPQLKLHIKEECVIPIPCYK---PKEKSPVEAKLPWLKQAQELEETRIATEEP 566
+ + + + E+ P PC P ++A K R +
Sbjct: 835 ADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAA 894
Query: 567 TFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACD 626
+CS +CG G+ ++ R L + + EE C P R E C
Sbjct: 895 HVWTPAAGSCSVSCGRGL----MELRFLCMDSALRVPVQEELCGLASKPGSR---REVCQ 947
Query: 627 ESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHI----QTQQTVND 682
P W+Y C+ +C G I C ++ + D
Sbjct: 948 AVPCPAR--------------WQYK-LAACSVSCGRGVVRRILYCARAHGEDDGEEILLD 992
Query: 683 SLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYC--LHPGETPAPP 740
+ C + RP +AC+ EPCPPRW V S GPCSA+CG+G R V C L G+
Sbjct: 993 TQCQGLPRPEP-QEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVD 1051
Query: 741 EECRDE--KPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTC 786
E +P A C DC WH+ W +CS +CG G Q RR TC
Sbjct: 1052 EAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTC 1099
Score = 171 bits (432), Expect = 7e-42
Identities = 139/503 (27%), Positives = 206/503 (40%), Gaps = 82/503 (16%)
Query: 413 YDHFQPLPRWEHNPWTA----CSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKP 468
+ +FQP PR + W A CSVSCG G++ ++ C++++ VE +C + +P
Sbjct: 675 FTYFQPKPR-QAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKE---LVETVQCQGSQQP 730
Query: 469 KVM-QTCNLFDCPK-WIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKE 526
+ C L CP W ++ C+ +CG GLR R V C+ +G +
Sbjct: 731 PAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLL------------- 777
Query: 527 ECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPW-----SACSTTCG 581
K P + + A LE T P P W S+C++ G
Sbjct: 778 -----------KTLPPARCRAGAQQPAVALE-----TCNPQPCPARWEVSEPSSCTSAGG 821
Query: 582 PGVQVREVKCRVLLTFTQTETELPEEECEGP-----KLPTERPCLLEAC-------DESP 629
G+ + C L EGP KLP PC+ +C D +
Sbjct: 822 AGLALENETC------VPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATS 875
Query: 630 ASRELDIP---LPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCD 686
A + P + ++ + W A + C+ +C G E +C+ + V + LC
Sbjct: 876 AGEKAPSPWGSIRTGAQAAHVWTPAAGS-CSVSCGRGLMELRFLCMDSALRVPVQEELCG 934
Query: 687 MVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHP-----GETPAPPE 741
+ +P + + C PCP RW CS +CG G+ R +YC GE
Sbjct: 935 LASKPGSRREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDT 993
Query: 742 ECRD-EKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSD 800
+C+ +P +AC+ CPP W + CS +CG GT R V C QL G + + +
Sbjct: 994 QCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQL-DQGQDVEVDE 1052
Query: 801 ELCQG---PKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIP 857
C P+AS C DC VG W +CSVSCG GIQRR+ C A+ P
Sbjct: 1053 AACAALVRPEASV--PCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQA---P 1107
Query: 858 LSEMMCRDLPGLPLVRSCQMPEC 880
+ C+ LP VR C C
Sbjct: 1108 VPADFCQHLPKPVTVRGCWAGPC 1130
Score = 95.9 bits (237), Expect = 3e-19
Identities = 105/447 (23%), Positives = 152/447 (34%), Gaps = 136/447 (30%)
Query: 337 QPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIR--LKRVVPDHYCHYYPENVKPKPKLK 394
+P W DF PC+ +CGGG + CV+ + L + +P C + +P L+
Sbjct: 740 EPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQ--QPAVALE 797
Query: 395 ECSMDPC----------------------------PSSDGFKEIMP-----YDHFQPLPR 421
C+ PC P +DG + + D P P
Sbjct: 798 TCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPE 857
Query: 422 ----------WEH-----------NPWTA-----------------CSVSCGGGIQRRSF 443
W H +PW + CSVSCG G+ F
Sbjct: 858 PCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRF 917
Query: 444 VCVEESMHGEILQVEEWKCMYAPKP-KVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRV 502
+C++ ++ + V+E C A KP + C CP + + C+V+CGRG+ R+
Sbjct: 918 LCMDSALR---VPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRI 974
Query: 503 VLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIA 562
+ C GE G EE ++ C P EA
Sbjct: 975 LYCARAHGEDDG-----------EEILLDTQCQGLPRPEPQEA----------------C 1007
Query: 563 TEEPTFIPEPWSA-----CSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLP-T 616
+ EP P W CS +CG G R V C V L Q + E+ E C P
Sbjct: 1008 SLEP--CPPRWKVMSLGPCSASCGLGTARRSVAC-VQLDQGQ-DVEVDEAACAALVRPEA 1063
Query: 617 ERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQT 676
PCL+ C TY W + C+ +C G Q CL Q
Sbjct: 1064 SVPCLIADC-------------------TYRWHVGTWMECSVSCGDGIQRRRDTCLGPQA 1104
Query: 677 QQTVNDSLCDMVHRPPAMSQACNTEPC 703
Q V C + +P + + C PC
Sbjct: 1105 QAPVPADFCQHLPKPVTV-RGCWAGPC 1130
Score = 93.6 bits (231), Expect = 1e-18
Identities = 70/237 (29%), Positives = 95/237 (40%), Gaps = 12/237 (5%)
Query: 1428 WEPGNWSHCSATCGHLGARIQRPQCV-MANGQEVSEALCDHLQKPLAGFEPCNIRDCPAR 1486
W P S CS +CG G R C+ A V E LC KP + E C CPAR
Sbjct: 897 WTPAAGS-CSVSCGR-GLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPAR 954
Query: 1487 WFTSVWSQCSVSCGEGYHSRQVTCKRTKANGT-VQVVSPRACAPKDRPLGRKPCFGHPCV 1545
W + + CSVSCG G R + C R +++ C RP ++ C PC
Sbjct: 955 WQYKL-AACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCP 1013
Query: 1546 -QWEPGNR--CPGRC----MGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGACD 1598
+W+ + C C R+V Q ++ C RP C C
Sbjct: 1014 PRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCT 1073
Query: 1599 VCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSC 1655
WH G W C+ +CG G Q R+ C+ ++ PV C KP++ R C C
Sbjct: 1074 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 68.6 bits (166), Expect = 5e-11
Identities = 64/238 (26%), Positives = 92/238 (38%), Gaps = 32/238 (13%)
Query: 1423 PQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANG---QEVSEALCDH-LQKPLAGFEPC 1478
P P+W G++ CSA+CG G R + +CV A G + + A C Q+P E C
Sbjct: 741 PCPPYWAVGDFGPCSASCGG-GLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETC 799
Query: 1479 NIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKP 1538
N + CPARW S S C+ + G G TC A+G V+ + ++ +P
Sbjct: 800 NPQPCPARWEVSEPSSCTSAGGAGLALENETCV-PGADGLEAPVTEGPGSVDEKLPAPEP 858
Query: 1539 CFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGACD 1598
C G C PG D+ K P+ + +GA
Sbjct: 859 CVGMSC---PPG----------------------WGHLDATSAGEKAPSPWGSIRTGAQA 893
Query: 1599 VCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRH-CLGPSC 1655
T C+ +CGRG + C+ + PV + C KP S R C C
Sbjct: 894 AHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPC 951
Score = 62.0 bits (149), Expect = 5e-09
Identities = 75/310 (24%), Positives = 103/310 (33%), Gaps = 52/310 (16%)
Query: 1393 RIVFLQGHKKYILQATNTRTNSNDP-----TGEPPPQEPFWEPGNWSHCSATCGHLGARI 1447
R V QG L R + P T P P WE S C++ G G +
Sbjct: 768 RCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSA-GGAGLAL 826
Query: 1448 QRPQCVM-ANGQE--VSEALCDHLQKPLAGFEPCNIRDCPARW----------------- 1487
+ CV A+G E V+E + + L EPC CP W
Sbjct: 827 ENETCVPGADGLEAPVTEGP-GSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWG 885
Query: 1488 -----------FTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGR 1536
+T CSVSCG G + C + VQ C +P R
Sbjct: 886 SIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQ---EELCGLASKPGSR 942
Query: 1537 KP-CFGHPC-VQWEPGNRCPGRCMGRAVRMQQRHTACQHNSS-------DSNCDDRKRPT 1587
+ C PC +W+ GR V + + A H D+ C RP
Sbjct: 943 REVCQAVPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPE 1002
Query: 1588 LRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVA--KRHCVQKKKPI 1645
+ C+ C W PC+A+CG G R V C+ + V + C +P
Sbjct: 1003 PQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPE 1062
Query: 1646 SWRHCLGPSC 1655
+ CL C
Sbjct: 1063 ASVPCLIADC 1072
Score = 36.6 bits (83), Expect = 0.21
Identities = 14/43 (32%), Positives = 20/43 (46%)
Query: 1586 PTLRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTR 1628
P C C W G + PC+A+CG G + R V C+ +
Sbjct: 731 PAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQ 773
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif,
7 preproprotein [Homo sapiens]
Length = 1686
Score = 231 bits (590), Expect = 3e-60
Identities = 147/464 (31%), Positives = 209/464 (45%), Gaps = 49/464 (10%)
Query: 72 EDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPP 125
E DG W W WS CSR+CG G + R+C GR C G+ R++ C+ CP
Sbjct: 535 EAVDGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPA 594
Query: 126 DAEDFRAQQCSAYNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLDGTR 185
FR QCS ++ + Y+G + W+P ND PC L C + +L V+DGT
Sbjct: 595 GRPSFRHVQCSHFDAMLYKGQLHTWVPVVND-VNPCELHCRPANEYFAEKLRDAVVDGTP 653
Query: 186 CNT--DSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKR 243
C S D+CI+GIC+ VGCD ++ S A ED CGVC G+GSTC V G + +
Sbjct: 654 CYQVRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEE--AEGLG 711
Query: 244 EENVIAVPLGSRSVRITVKGPAHLFIESKTLQGSK----GEHSFNSPGVFLVENTTVEFQ 299
+V +P G+R +RI A F+ ++ K G + G + V TT +
Sbjct: 712 YVDVGLIPAGAREIRIQEVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYA 771
Query: 300 RGSERQTFKIPGPLMADFIFKTRYTAAKDSV-VQFFFYQ---------PISHQWRQTDFF 349
R + PGP + + + V ++ ++ P W +
Sbjct: 772 RRGNWENLTSPGPTKEPVWIQLLFQESNPGVHYEYTIHREAGGHDEVPPPVFSWHYGPWT 831
Query: 350 PCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKE 409
CTVTCG G Q + C++ R V + +C +P + ++CS PCP+
Sbjct: 832 KCTVTCGRGVQRQNVYCLE-RQAGPVDEEHCDPLG---RPDDQQRKCSEQPCPA------ 881
Query: 410 IMPYDHFQPLPRWEHNPWTACSVSCG-GGIQRRSFVCVEESMHGEILQVEEWKCMYAPKP 468
RW W CS SCG GG+ RR+ +C+ E +E C + P+P
Sbjct: 882 -----------RWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRP 930
Query: 469 KVMQTCNL-FDCP-KWIAMEWSQCTVTCGRGLRYRVVLCINHRG 510
CN CP W WSQC+VTCG G + R VLC N G
Sbjct: 931 PTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTG 974
Score = 129 bits (323), Expect = 3e-29
Identities = 89/285 (31%), Positives = 125/285 (43%), Gaps = 37/285 (12%)
Query: 1422 PPQEPF------WEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGF 1475
PP +P W+ GNWS CS TCG LGA + +C ++ C +P
Sbjct: 1403 PPADPLVVRNAGWQAGNWSECSTTCG-LGAVWRPVRCSSGRDED-----CAPAGRPQPA- 1455
Query: 1476 EPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKD-RPL 1534
C++R C A W + WS+CS SCG G R V C T+ ++ + P C P +P
Sbjct: 1456 RRCHLRPC-ATWHSGNWSKCSRSCGGGSSVRDVQCVDTR---DLRPLRPFHCQPGPAKPP 1511
Query: 1535 GRKPCFGHPCVQWEPGN--RCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNC 1592
+PC PC+ W + C C G QQR C C++ RP R C
Sbjct: 1512 AHRPCGAQPCLSWYTSSWRECSEACGGGE---QQRLVTCPEPGL---CEEALRPNTTRPC 1565
Query: 1593 TSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVA-KRHCVQKKKPISWRHC- 1650
+ C W GPW C+ CG G Q R V C++T++ P C + P S R C
Sbjct: 1566 NTHPCTQ-WVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCG 1624
Query: 1651 -------LGPSCDRDCTDTTHYCMFVKHLNLCSLDRYKQRCCQSC 1688
P C+RD + +C ++ L C L + +CC+SC
Sbjct: 1625 TEDCEPVEPPRCERDRL-SFGFCETLRLLGRCQLPTIRTQCCRSC 1668
Score = 108 bits (271), Expect = 3e-23
Identities = 65/175 (37%), Positives = 85/175 (48%), Gaps = 12/175 (6%)
Query: 707 WHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRD-EKPHALQ-ACNQFDCPPGWH 764
WH G W C+ TCG G+Q ++VYCL P E C +P Q C++ CP W
Sbjct: 825 WHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWW 884
Query: 765 IEEWQQCSRTCG-GGTQNRRVTCRQLLTDGSFLNLSDELCQG-PKASSHKSCAR-TDCPP 821
EWQ CS +CG GG R V C + + L C+ P+ + C R CP
Sbjct: 885 AGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPA 944
Query: 822 HLAVGDWSKCSVSCGVGIQRRKQVCQR---LAAKGRRIPLSEMMCRDLPGLPLVR 873
AVG+WS+CSV+CG G QRR +C + + P SE+ C LPL R
Sbjct: 945 TWAVGNWSQCSVTCGEGTQRRNVLCTNDTGVPCDEAQQPASEVTC----SLPLCR 995
Score = 104 bits (260), Expect = 6e-22
Identities = 54/148 (36%), Positives = 71/148 (47%), Gaps = 8/148 (5%)
Query: 646 YDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPP 705
+ W Y +T CT TC G Q CL Q V++ CD + RP + C+ +PCP
Sbjct: 823 FSWHYGPWTKCTVTCGRGVQRQNVYCLERQA-GPVDEEHCDPLGRPDDQQRKCSEQPCPA 881
Query: 706 RWHVGSWGPCSATCGV-GIQTRDVYCLH----PGETPAPPEECRD-EKPHALQACNQ-FD 758
RW G W CS++CG G+ R V C+ ++ P C +P CN+
Sbjct: 882 RWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVP 941
Query: 759 CPPGWHIEEWQQCSRTCGGGTQNRRVTC 786
CP W + W QCS TCG GTQ R V C
Sbjct: 942 CPATWAVGNWSQCSVTCGEGTQRRNVLC 969
Score = 101 bits (252), Expect = 5e-21
Identities = 82/289 (28%), Positives = 112/289 (38%), Gaps = 82/289 (28%)
Query: 482 WIAMEWSQCTVTCGRGLRYRVVLCINHRGEH---VGGCNPQLKLHIKEECVIPIPCYKPK 538
W A WS+C+ TCG G +R V C + R E G P + H++ PC
Sbjct: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGRDEDCAPAGRPQPARRCHLR-------PC---- 1463
Query: 539 EKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFT 598
T+ WS CS +CG G VR+V+C T
Sbjct: 1464 ---------------------------ATWHSGNWSKCSRSCGGGSSVRDVQC----VDT 1492
Query: 599 QTETELPEEECE-GP-KLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPC 656
+ L C+ GP K P RPC + C W + + C
Sbjct: 1493 RDLRPLRPFHCQPGPAKPPAHRPCGAQPC--------------------LSWYTSSWREC 1532
Query: 657 TATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCS 716
+ C GG Q+ + C LC+ RP ++ CNT PC +W VG WG CS
Sbjct: 1533 SEACGGGEQQRLVTC--------PEPGLCEEALRPNT-TRPCNTHPCT-QWVVGPWGQCS 1582
Query: 717 ATCGVGIQTRDVYCLHPGETPAPPE---ECRDEK-PHALQACNQFDCPP 761
CG G+Q R V C++ +T P E +C E P + + C DC P
Sbjct: 1583 GPCGGGVQRRLVKCVNT-QTGLPEEDSDQCGHEAWPESSRPCGTEDCEP 1630
Score = 100 bits (250), Expect = 9e-21
Identities = 76/282 (26%), Positives = 112/282 (39%), Gaps = 36/282 (12%)
Query: 569 IPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDES 628
+PEP + GP Q + V L+ T + ++P +P +
Sbjct: 1347 MPEP----ALNPGPKGQPESLSPEVPLSSRLLSTPAWDSPANSHRVPETQPLAPSLAEAG 1402
Query: 629 PASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMV 688
P + L + W+ ++ C+ TC G C + D C
Sbjct: 1403 PPADPLVV-------RNAGWQAGNWSECSTTCGLGAVWRPVRC------SSGRDEDCAPA 1449
Query: 689 HRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGET-PAPPEECRD-- 745
RP ++ C+ PC WH G+W CS +CG G RDV C+ + P P C+
Sbjct: 1450 GRPQP-ARRCHLRPCAT-WHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGP 1507
Query: 746 EKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELC-Q 804
KP A + C C W+ W++CS CGGG Q R VTC + LC +
Sbjct: 1508 AKPPAHRPCGAQPCL-SWYTSSWRECSEACGGGEQQRLVTCPE-----------PGLCEE 1555
Query: 805 GPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVC 846
+ ++ + C C VG W +CS CG G+QRR C
Sbjct: 1556 ALRPNTTRPCNTHPC-TQWVVGPWGQCSGPCGGGVQRRLVKC 1596
Score = 95.1 bits (235), Expect = 5e-19
Identities = 64/194 (32%), Positives = 83/194 (42%), Gaps = 12/194 (6%)
Query: 1420 EPPPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCN 1479
E PP W G W+ C+ TCG G + Q C+ V E CD L +P C+
Sbjct: 817 EVPPPVFSWHYGPWTKCTVTCGR-GVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCS 875
Query: 1480 IRDCPARWFTSVWSQCSVSCGEGYHSRQ-VTCKRTKANGTVQVVSPRACAPKDRPLGRKP 1538
+ CPARW+ W CS SCG G SR+ V C R+ + P AC RP P
Sbjct: 876 EQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETP 935
Query: 1539 CFGH-PC-VQWEPGN--RCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTS 1594
C H PC W GN +C C Q+R+ C N + CD+ ++P C+
Sbjct: 936 CNRHVPCPATWAVGNWSQCSVTC---GEGTQRRNVLCT-NDTGVPCDEAQQPASEVTCSL 991
Query: 1595 GACDVCWHTGPWKP 1608
C W G P
Sbjct: 992 PLCR--WPLGTLGP 1003
Score = 91.3 bits (225), Expect = 7e-18
Identities = 49/165 (29%), Positives = 71/165 (43%), Gaps = 32/165 (19%)
Query: 343 WRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCP 402
W ++ C+ +CGGG + +CVD R R + +C P KP P + C PC
Sbjct: 1466 WHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQ--PGPAKP-PAHRPCGAQPCL 1522
Query: 403 SSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKC 462
S W + W CS +CGGG Q+R C E + C
Sbjct: 1523 S------------------WYTSSWRECSEACGGGEQQRLVTCPEPGL-----------C 1553
Query: 463 MYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCIN 507
A +P + CN C +W+ W QC+ CG G++ R+V C+N
Sbjct: 1554 EEALRPNTTRPCNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKCVN 1598
Score = 87.4 bits (215), Expect = 1e-16
Identities = 73/289 (25%), Positives = 103/289 (35%), Gaps = 79/289 (27%)
Query: 343 WRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCP 402
W+ ++ C+ TCG G C R + P +P+P + C + PC
Sbjct: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGRDEDCAPAG---------RPQPA-RRCHLRPCA 1464
Query: 403 SSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKC 462
+ W W+ CS SCGGG R CV+ ++ + + C
Sbjct: 1465 T------------------WHSGNWSKCSRSCGGGSSVRDVQCVDTR---DLRPLRPFHC 1503
Query: 463 MYAP-KPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLK 521
P KP + C C W W +C+ CG G + R+V C G C L+
Sbjct: 1504 QPGPAKPPAHRPCGAQPCLSWYTSSWRECSEACGGGEQQRLVTC-----PEPGLCEEALR 1558
Query: 522 LHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCG 581
+ C PC + ++ PW CS CG
Sbjct: 1559 PNTTRPCNTH-PCTQ-------------------------------WVVGPWGQCSGPCG 1586
Query: 582 PGVQVREVKCRVLLTFTQTETELPEE---ECEGPKLP-TERPCLLEACD 626
GVQ R VKC T+T LPEE +C P + RPC E C+
Sbjct: 1587 GGVQRRLVKC------VNTQTGLPEEDSDQCGHEAWPESSRPCGTEDCE 1629
Score = 80.1 bits (196), Expect = 2e-14
Identities = 49/177 (27%), Positives = 74/177 (41%), Gaps = 28/177 (15%)
Query: 572 PWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPAS 631
PW+ C+ TCG GVQ + V C + + EE C+ P ++ C E P
Sbjct: 829 PWTKCTVTCGRGVQRQNVYC-----LERQAGPVDEEHCDPLGRPDDQQ---RKCSEQPCP 880
Query: 632 RELDIPLPEDSETTYDWEYAGFTPCTATC-VGGHQEAIAVCLH---IQTQQTVNDSLCDM 687
W + C+++C GG +C+ + Q + C+
Sbjct: 881 AR--------------WWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEH 926
Query: 688 VHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECR 744
+ RPP + PCP W VG+W CS TCG G Q R+V C + +T P +E +
Sbjct: 927 LPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTN--DTGVPCDEAQ 981
Score = 62.4 bits (150), Expect = 4e-09
Identities = 47/180 (26%), Positives = 65/180 (36%), Gaps = 21/180 (11%)
Query: 1487 WFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGR-KPCFGHPC- 1544
W W++C+V+CG G + V C +A V C P RP + + C PC
Sbjct: 825 WHYGPWTKCTVTCGRGVQRQNVYCLERQAGP----VDEEHCDPLGRPDDQQRKCSEQPCP 880
Query: 1545 VQWEPGN--RCPGRC----MGRAVRMQQRHTACQHNSS--DSNCDDRKRPTLRRNCTSGA 1596
+W G C C + R + R S+ C+ RP C
Sbjct: 881 ARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHV 940
Query: 1597 -CDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSC 1655
C W G W C+ CG G Q R V C + C + ++P S C P C
Sbjct: 941 PCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTGVP------CDEAQQPASEVTCSLPLC 994
Score = 43.9 bits (102), Expect = 0.001
Identities = 29/93 (31%), Positives = 44/93 (47%), Gaps = 11/93 (11%)
Query: 1543 PCVQWE--PGNRCPGRCMGRAVRMQQRHTACQHNSS----DSNCDDRKRPT-LRRNCTSG 1595
P W P +C C GR V Q+++ C + + +CD RP +R C+
Sbjct: 821 PVFSWHYGPWTKCTVTC-GRGV--QRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQ 877
Query: 1596 ACDVCWHTGPWKPCTAACGRGFQSRK-VDCIHT 1627
C W G W+ C+++CG G SR+ V CI +
Sbjct: 878 PCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRS 910
Score = 39.3 bits (90), Expect = 0.033
Identities = 84/363 (23%), Positives = 123/363 (33%), Gaps = 85/363 (23%)
Query: 573 WSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPASR 632
WS CS +CG GVQ E +C TQ + C G + R C L+AC PA R
Sbjct: 547 WSICSRSCGMGVQSAERQC------TQPTPKYKGRYCVGER-KRFRLCNLQAC---PAGR 596
Query: 633 ---------ELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQ-------EAI---AVCLH 673
D L + T+ PC C ++ +A+ C
Sbjct: 597 PSFRHVQCSHFDAMLYKGQLHTWVPVVNDVNPCELHCRPANEYFAEKLRDAVVDGTPCYQ 656
Query: 674 IQTQQTV------NDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRD 727
++ + + + CD AM C C G+ C G +
Sbjct: 657 VRASRDLCINGICKNVGCDFEIDSGAMEDRCGV--CH-----GNGSTCHTVSGTFEEAEG 709
Query: 728 VYCLHPGETPAPPEECRDEKPHALQACN----------QFDCPPGWHIEEWQQCSRTCG- 776
+ + G PA E R ++ +A N ++ GW I +W + G
Sbjct: 710 LGYVDVGLIPAGAREIRIQE--VAEAANFLALRSEDPEKYFLNGGWTI-QWNGDYQVAGT 766
Query: 777 -------GGTQN-------RRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPH 822
G +N + QLL S + E +A H + PP
Sbjct: 767 TFTYARRGNWENLTSPGPTKEPVWIQLLFQESNPGVHYEYTIHREAGGH-----DEVPPP 821
Query: 823 L---AVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLP--LVRSCQM 877
+ G W+KC+V+CG G+QR+ C A P+ E C L G P R C
Sbjct: 822 VFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAG----PVDEEHCDPL-GRPDDQQRKCSE 876
Query: 878 PEC 880
C
Sbjct: 877 QPC 879
Score = 39.3 bits (90), Expect = 0.033
Identities = 21/62 (33%), Positives = 30/62 (48%), Gaps = 14/62 (22%)
Query: 74 KDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQ 133
++ W A G+WS+CS TCG GA + RC +GR + DC P A+
Sbjct: 1411 RNAGWQA-GNWSECSTTCGLGAVWRPVRCSSGR-------------DEDCAPAGRPQPAR 1456
Query: 134 QC 135
+C
Sbjct: 1457 RC 1458
Score = 37.0 bits (84), Expect = 0.16
Identities = 25/77 (32%), Positives = 31/77 (40%), Gaps = 9/77 (11%)
Query: 1411 RTNSNDPTGEPPPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQK 1470
R + P P W GNWS CS TCG G + + C G CD Q+
Sbjct: 929 RPPTETPCNRHVPCPATWAVGNWSQCSVTCGE-GTQRRNVLCTNDTG-----VPCDEAQQ 982
Query: 1471 PLAGFEPCNIRDCPARW 1487
P A C++ C RW
Sbjct: 983 P-ASEVTCSLPLC--RW 996
Score = 34.7 bits (78), Expect = 0.81
Identities = 21/63 (33%), Positives = 29/63 (46%), Gaps = 4/63 (6%)
Query: 711 SWGPCSATCGVGIQTRDVYCLHPGETPA-PPEECRDEKPHALQACNQFDCPPGWHIEEWQ 769
+W CS +CG+G+Q+ + C P TP C E+ + CN CP G
Sbjct: 546 AWSICSRSCGMGVQSAERQCTQP--TPKYKGRYCVGERKR-FRLCNLQACPAGRPSFRHV 602
Query: 770 QCS 772
QCS
Sbjct: 603 QCS 605
Score = 34.3 bits (77), Expect = 1.1
Identities = 13/26 (50%), Positives = 19/26 (73%)
Query: 82 GDWSDCSRTCGGGASYSLRRCLTGRN 107
G+WS CSR+CGGG+S +C+ R+
Sbjct: 1469 GNWSKCSRSCGGGSSVRDVQCVDTRD 1494
Score = 31.6 bits (70), Expect = 6.8
Identities = 16/43 (37%), Positives = 20/43 (46%), Gaps = 4/43 (9%)
Query: 84 WSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKT---CSNHDC 123
W +CS CGGG L C CE + +R T C+ H C
Sbjct: 1529 WRECSEACGGGEQQRLVTCPEPGLCE-EALRPNTTRPCNTHPC 1570
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 229 bits (585), Expect = 1e-59
Identities = 145/469 (30%), Positives = 218/469 (46%), Gaps = 53/469 (11%)
Query: 69 RSDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRC------LTGRNCEGQNIRYKTCSNHD 122
+ E G W W WS CSRTCG G + R C G+ C G+ RY+ C+ H
Sbjct: 536 KKPESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHP 595
Query: 123 CPPDAEDFRAQQCSAYNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLD 182
C +A FR QCS ++ V Y+ Y W P +N PA PC L C ++ V+D
Sbjct: 596 CRSEAPTFRQMQCSEFDTVPYKNELYHWFPIFN-PAHPCELYCRPIDGQFSEKMLDAVID 654
Query: 183 GTRC--NTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSP 240
GT C +S ++CI+GIC+ VGCD ++ SNA ED CGVC GDGS+C+ VR K
Sbjct: 655 GTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQ--KE 712
Query: 241 EKREENVIAVPLGSRSVRITVKGPAHLFIESKTLQGSK----GEHSFNSPGVFLVENTTV 296
++ +P G+R +R+ A F+ ++ K G G + + T
Sbjct: 713 GSGYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVF 772
Query: 297 EFQRGSERQTFKIPGP----LMADFIF-------KTRYTAAKDSVVQFFFYQPISHQWRQ 345
++ R + + GP + +F K YT KD + Q + W+
Sbjct: 773 QYDRKGDLEKLMATGPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDNDVEQQ--MYFWQY 830
Query: 346 TDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSD 405
+ C+VTCG G + +A C+ + + +V +C PE +P + K+C CP
Sbjct: 831 GHWTECSVTCGTGIRRQTAHCIK-KGRGMVKATFCD--PE-TQPNGRQKKCHEKACP--- 883
Query: 406 GFKEIMPYDHFQPLPRWEHNPWTACSVSCG-GGIQRRSFVCVEESMHGEILQVEEWKCMY 464
PRW W ACS +CG G ++R+ +C+ ++M + + C +
Sbjct: 884 --------------PRWWAGEWEACSATCGPHGEKKRTVLCI-QTMVSDEQALPPTDCQH 928
Query: 465 APKPKVMQTCNL-FDCPK-WIAMEWSQCTVTCGRGLRYRVVLCINHRGE 511
KPK + +CN CP W WS+C+V+CG G+R R V C + E
Sbjct: 929 LLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDE 977
Score = 127 bits (318), Expect = 1e-28
Identities = 84/275 (30%), Positives = 126/275 (45%), Gaps = 30/275 (10%)
Query: 1428 WEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARW 1487
W GNWS CS TCG LGA +R +C + C +Q+P + C++R C A W
Sbjct: 1317 WIVGNWSECSTTCG-LGAYWRRVECSTQMDSD-----CAAIQRPDPA-KRCHLRPC-AGW 1368
Query: 1488 FTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPCVQW 1547
WS+CS +C G+ R++ C ++ + ++ + A PL C PC W
Sbjct: 1369 KVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMS-CNPEPCEAW 1427
Query: 1548 --EPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGACDVC-WHTG 1604
EP ++C C G +Q+R C CD KRPT +C C C W TG
Sbjct: 1428 QVEPWSQCSRSCGGG---VQERGVFCPGGL----CDWTKRPTSTMSCNEHLC--CHWATG 1478
Query: 1605 PWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCV--QKKKPISWRHCLGPSCDRD---- 1658
W C+ +CG GFQ R V C+ + K + C+ K +P ++ C +C +
Sbjct: 1479 NWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADLL 1538
Query: 1659 CTD---TTHYCMFVKHLNLCSLDRYKQRCCQSCQE 1690
CT + +C +K + CS+ + CC SC +
Sbjct: 1539 CTKDKLSASFCQTLKAMKKCSVPTVRAECCFSCPQ 1573
Score = 111 bits (278), Expect = 5e-24
Identities = 67/198 (33%), Positives = 94/198 (47%), Gaps = 17/198 (8%)
Query: 646 YDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPP 705
Y W+Y +T C+ TC G + A C+ + + V + CD +P + C+ + CPP
Sbjct: 826 YFWQYGHWTECSVTCGTGIRRQTAHCIK-KGRGMVKATFCDPETQPNGRQKKCHEKACPP 884
Query: 706 RWHVGSWGPCSATCGV-GIQTRDVYCLH---PGETPAPPEECRD-EKPHALQACNQ-FDC 759
RW G W CSATCG G + R V C+ E PP +C+ KP L +CN+ C
Sbjct: 885 RWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILC 944
Query: 760 PPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQ-GPKASSHKSCARTD 818
P W + W +CS +CGGG + R VTC + DE C K +S C
Sbjct: 945 PSDWTVGNWSECSVSCGGGVRIRSVTCAK---------NHDEPCDVTRKPNSRALCGLQQ 995
Query: 819 CPPHLAVGDWSKCSVSCG 836
CP V +K ++S G
Sbjct: 996 CPSSRRVLKPNKGTISNG 1013
Score = 110 bits (274), Expect = 2e-23
Identities = 74/248 (29%), Positives = 102/248 (41%), Gaps = 28/248 (11%)
Query: 648 WEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRW 707
W ++ C+ TC G C T DS C + RP ++ C+ PC W
Sbjct: 1317 WIVGNWSECSTTCGLGAYWRRVEC------STQMDSDCAAIQRPDP-AKRCHLRPCAG-W 1368
Query: 708 HVGSWGPCSATCGVGIQTRDVYCL----HPGETPAPPEECRDEKPHALQACNQFDCPPGW 763
VG+W CS C G + R++ C+ H P + P +CN C W
Sbjct: 1369 KVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCE-AW 1427
Query: 764 HIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHL 823
+E W QCSR+CGGG Q R V C L D + S C + H C H
Sbjct: 1428 QVEPWSQCSRSCGGGVQERGVFCPGGLCDWTKRPTSTMSC-----NEHLCC-------HW 1475
Query: 824 AVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRI-PLSEMMCRDLPGLPLVRSCQMPECSK 882
A G+W CS SCG G Q+R C + ++G + + +C P P + C C K
Sbjct: 1476 ATGNWDLCSTSCGGGFQKRTVQC--VPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKK 1533
Query: 883 IKSEMKTK 890
+ TK
Sbjct: 1534 SADLLCTK 1541
Score = 97.1 bits (240), Expect = 1e-19
Identities = 56/153 (36%), Positives = 73/153 (47%), Gaps = 18/153 (11%)
Query: 707 WHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDE-KPHALQA-CNQFDCPPGWH 764
W G W CS TCG GI+ + +C+ G C E +P+ Q C++ CPP W
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWW 887
Query: 765 IEEWQQCSRTCGG-GTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHK-------SCAR 816
EW+ CS TCG G + R V C Q + +SDE P H SC R
Sbjct: 888 AGEWEACSATCGPHGEKKRTVLCIQTM-------VSDEQALPPTDCQHLLKPKTLLSCNR 940
Query: 817 TD-CPPHLAVGDWSKCSVSCGVGIQRRKQVCQR 848
CP VG+WS+CSVSCG G++ R C +
Sbjct: 941 DILCPSDWTVGNWSECSVSCGGGVRIRSVTCAK 973
Score = 85.1 bits (209), Expect = 5e-16
Identities = 44/168 (26%), Positives = 68/168 (40%), Gaps = 32/168 (19%)
Query: 343 WRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCP 402
W+ ++ C+ C GG+++ +CVD R R + +C + P P C+ +PC
Sbjct: 1368 WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGI--PPPLSMSCNPEPCE 1425
Query: 403 SSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKC 462
+ W+ PW+ CS SCGGG+Q R C C
Sbjct: 1426 A------------------WQVEPWSQCSRSCGGGVQERGVFC------------PGGLC 1455
Query: 463 MYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRG 510
+ +P +CN C W W C+ +CG G + R V C+ G
Sbjct: 1456 DWTKRPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEG 1503
Score = 80.5 bits (197), Expect = 1e-14
Identities = 69/284 (24%), Positives = 99/284 (34%), Gaps = 71/284 (25%)
Query: 422 WEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPK 481
W W+ CS +CG G R C + + C +P + C+L C
Sbjct: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQM---------DSDCAAIQRPDPAKRCHLRPCAG 1367
Query: 482 WIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKS 541
W WS+C+ C G + R + C++ R P H + IP P
Sbjct: 1368 WKVGNWSKCSRNCSGGFKIREIQCVDSRDHR--NLRP---FHCQFLAGIPPPLSMSCNPE 1422
Query: 542 PVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTE 601
P EA + EPWS CS +CG GVQ R V C
Sbjct: 1423 PCEA----------------------WQVEPWSQCSRSCGGGVQERGVFC---------- 1450
Query: 602 TELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCV 661
P C+ T+RP +C+E W + C+ +C
Sbjct: 1451 ---PGGLCDW----TKRPTSTMSCNE---------------HLCCHWATGNWDLCSTSCG 1488
Query: 662 GGHQEAIAVCLHIQTQQTVNDS--LCDMVHRPPAMSQACNTEPC 703
GG Q+ C+ + +T + LCD RPP + CN + C
Sbjct: 1489 GGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKK-CNQQAC 1531
Score = 80.1 bits (196), Expect = 2e-14
Identities = 55/176 (31%), Positives = 72/176 (40%), Gaps = 11/176 (6%)
Query: 1427 FWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPAR 1486
FW+ G+W+ CS TCG G R Q C+ V CD +P + C+ + CP R
Sbjct: 827 FWQYGHWTECSVTCG-TGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPR 885
Query: 1487 WFTSVWSQCSVSCG-EGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPCV 1545
W+ W CS +CG G R V C +T + Q + P C +P C
Sbjct: 886 WWAGEWEACSATCGPHGEKKRTVLCIQTMVSDE-QALPPTDCQHLLKPKTLLSCNRDILC 944
Query: 1546 --QWEPGN--RCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGAC 1597
W GN C C G VR+ R C N D CD ++P R C C
Sbjct: 945 PSDWTVGNWSECSVSC-GGGVRI--RSVTCAKN-HDEPCDVTRKPNSRALCGLQQC 996
Score = 73.9 bits (180), Expect = 1e-12
Identities = 64/231 (27%), Positives = 96/231 (41%), Gaps = 46/231 (19%)
Query: 408 KEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPK 467
K+ + D Q + W++ WT CSV+CG GI+R++ C+++ V+ C +
Sbjct: 814 KDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRG----MVKATFCDPETQ 869
Query: 468 PKVMQT-CNLFDCP-KWIAMEWSQCTVTCG-RGLRYRVVLCINHRGEHVGGCNPQLKLHI 524
P Q C+ CP +W A EW C+ TCG G + R VLCI +
Sbjct: 870 PNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQ-------------TMVS 916
Query: 525 KEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGV 584
E+ + P C LK L R + WS CS +CG GV
Sbjct: 917 DEQALPPTDCQH------------LLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGV 964
Query: 585 QVREVKCRVLLTFTQTETELPEEECEGPKLPTERP-CLLEACDESPASREL 634
++R V C + +E C+ + P R C L+ C P+SR +
Sbjct: 965 RIRSVTC----------AKNHDEPCDVTRKPNSRALCGLQQC---PSSRRV 1002
Score = 72.0 bits (175), Expect = 5e-12
Identities = 72/294 (24%), Positives = 105/294 (35%), Gaps = 78/294 (26%)
Query: 340 SHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMD 399
S W ++ C+ TCG G EC D C +P P K C +
Sbjct: 1314 SAHWIVGNWSECSTTCGLGAYWRRVEC------STQMDSDCAAIQ---RPDPA-KRCHLR 1363
Query: 400 PCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEE 459
PC W+ W+ CS +C GG + R CV+ H +
Sbjct: 1364 PCAG------------------WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNL---RP 1402
Query: 460 WKCMYAP--KPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCN 517
+ C + P + +CN C W WSQC+ +CG G++ R V C G C+
Sbjct: 1403 FHCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFCPG------GLCD 1456
Query: 518 PQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACS 577
+ C + C+ W AT W CS
Sbjct: 1457 WTKRPTSTMSCNEHLCCH-------------W------------ATGN-------WDLCS 1484
Query: 578 TTCGPGVQVREVKCRVLLTFTQTETELPEEEC---EGPKLPTERPCLLEACDES 628
T+CG G Q R V+C V +TE +++C P+ P + C +AC +S
Sbjct: 1485 TSCGGGFQKRTVQC-VPSEGNKTE---DQDQCLCDHKPRPPEFKKCNQQACKKS 1534
Score = 69.7 bits (169), Expect = 2e-11
Identities = 38/92 (41%), Positives = 48/92 (52%), Gaps = 7/92 (7%)
Query: 1426 PFWEPGNWSHCSATCGHLGARIQRPQCV---MANGQEVSEALCDHLQKPLAGFEPCNIRD 1482
P W G W CSATCG G + + C+ +++ Q + C HL KP CN RD
Sbjct: 884 PRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKT-LLSCN-RD 941
Query: 1483 --CPARWFTSVWSQCSVSCGEGYHSRQVTCKR 1512
CP+ W WS+CSVSCG G R VTC +
Sbjct: 942 ILCPSDWTVGNWSECSVSCGGGVRIRSVTCAK 973
Score = 67.4 bits (163), Expect = 1e-10
Identities = 52/198 (26%), Positives = 75/198 (37%), Gaps = 43/198 (21%)
Query: 573 WSACSTTCGPGVQVREVKC------RVLLTFTQTETELPEEECEGPKLPTERPCLLEACD 626
W+ CS TCG G++ + C V TF ET+ P ++ C +AC
Sbjct: 833 WTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQ-PNGR--------QKKCHEKACP 883
Query: 627 ESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQT----QQTVND 682
W + C+ATC G H E L IQT +Q +
Sbjct: 884 PR-------------------WWAGEWEACSATC-GPHGEKKRTVLCIQTMVSDEQALPP 923
Query: 683 SLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEE 742
+ C + +P + CP W VG+W CS +CG G++ R V C + P
Sbjct: 924 TDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDEPCDV-- 981
Query: 743 CRDEKPHALQACNQFDCP 760
KP++ C CP
Sbjct: 982 --TRKPNSRALCGLQQCP 997
Score = 60.8 bits (146), Expect = 1e-08
Identities = 49/178 (27%), Positives = 71/178 (39%), Gaps = 20/178 (11%)
Query: 1487 WFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGR-KPCFGHPCV 1545
W W++CSV+CG G + C + K G V+ C P+ +P GR K C C
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIK-KGRGMVKATF---CDPETQPNGRQKKCHEKACP 883
Query: 1546 -QWEPGN--RCPGRC-----MGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGA- 1596
+W G C C R V Q + + ++C +P +C
Sbjct: 884 PRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDIL 943
Query: 1597 CDVCWHTGPWKPCTAACGRGFQSRKVDCI--HTRSC----KPVAKRHCVQKKKPISWR 1648
C W G W C+ +CG G + R V C H C KP ++ C ++ P S R
Sbjct: 944 CPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDEPCDVTRKPNSRALCGLQQCPSSRR 1001
Score = 38.5 bits (88), Expect = 0.056
Identities = 20/58 (34%), Positives = 29/58 (50%), Gaps = 10/58 (17%)
Query: 789 LLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVC 846
L+T+G LN AS++K H VG+WS+CS +CG+G R+ C
Sbjct: 1293 LITEGFLLN----------ASNYKQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVEC 1340
Score = 34.7 bits (78), Expect = 0.81
Identities = 26/79 (32%), Positives = 32/79 (40%), Gaps = 20/79 (25%)
Query: 701 EPCPPRWHVGSWGP---CSATCGVGIQTRDVYCLHP----------GETP----APPEEC 743
E P W G W P CS TCG G+Q+ + C +P GE C
Sbjct: 539 ESIPGGW--GRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPC 596
Query: 744 RDEKPHALQ-ACNQFDCPP 761
R E P Q C++FD P
Sbjct: 597 RSEAPTFRQMQCSEFDTVP 615
Score = 34.7 bits (78), Expect = 0.81
Identities = 22/64 (34%), Positives = 29/64 (45%), Gaps = 8/64 (12%)
Query: 572 PWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEAC-DESPA 630
PWS CS TCG GVQ E C E + + C G + R C + C E+P
Sbjct: 550 PWSHCSRTCGAGVQSAERLC------NNPEPKFGGKYCTGER-KRYRLCNVHPCRSEAPT 602
Query: 631 SREL 634
R++
Sbjct: 603 FRQM 606
Score = 34.3 bits (77), Expect = 1.1
Identities = 16/62 (25%), Positives = 27/62 (43%)
Query: 80 AWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQCSAYN 139
A G+W CS +CGGG +C+ + ++ C + PP+ + Q C
Sbjct: 1476 ATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSA 1535
Query: 140 DV 141
D+
Sbjct: 1536 DL 1537
Score = 33.5 bits (75), Expect = 1.8
Identities = 21/77 (27%), Positives = 29/77 (37%), Gaps = 7/77 (9%)
Query: 1590 RNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRH 1649
+ T+G W G W C+ CG G R+V+C T+ A K R
Sbjct: 1306 KQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVEC-STQMDSDCAAIQRPDPAKRCHLRP 1364
Query: 1650 CLG------PSCDRDCT 1660
C G C R+C+
Sbjct: 1365 CAGWKVGNWSKCSRNCS 1381
Score = 32.7 bits (73), Expect = 3.1
Identities = 22/78 (28%), Positives = 30/78 (38%), Gaps = 25/78 (32%)
Query: 1428 WEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAG---------FEPC 1478
W P WSHCS TCG G + +E LC++ + G + C
Sbjct: 548 WSP--WSHCSRTCG--------------AGVQSAERLCNNPEPKFGGKYCTGERKRYRLC 591
Query: 1479 NIRDCPARWFTSVWSQCS 1496
N+ C + T QCS
Sbjct: 592 NVHPCRSEAPTFRQMQCS 609
Score = 32.0 bits (71), Expect = 5.2
Identities = 13/28 (46%), Positives = 14/28 (50%), Gaps = 1/28 (3%)
Query: 760 PPGW-HIEEWQQCSRTCGGGTQNRRVTC 786
P GW W CSRTCG G Q+ C
Sbjct: 542 PGGWGRWSPWSHCSRTCGAGVQSAERLC 569
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif, 3
proprotein [Homo sapiens]
Length = 1205
Score = 214 bits (545), Expect = 6e-55
Identities = 146/486 (30%), Positives = 213/486 (43%), Gaps = 62/486 (12%)
Query: 70 SDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDC 123
+ + +DGNW +W + CSRTCG G + R+C G++C G N Y+ C+ +C
Sbjct: 546 NQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEEC 605
Query: 124 PPDAEDFRAQQCSAYND-VQYQGHYYEWLP-RYNDPAAPCALKCHAQGQNLVVELAPKVL 181
EDFRAQQC N +YQ + WLP + DP C L C ++ V + V
Sbjct: 606 QKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVH 665
Query: 182 DGTRCN-TDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSP 240
DGT C+ D +C+ G C VGCD+++GSN ED CGVC GD S CR V+G +P
Sbjct: 666 DGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTR--TP 723
Query: 241 EKREE-NVIAVPLGSRSVRI--TVKGPAHLFIESKT----LQGSKGEHSFNSPGVFLVEN 293
K + +P G+R V I P L I+++ + KGE + F+
Sbjct: 724 RKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEA--KSRTFIDLG 781
Query: 294 TTVEFQRGSERQTFKIPGPLMADFI-------------FKTRYTAAKDSVVQFFFYQPI- 339
++ + ++ GPL I +Y +DSV I
Sbjct: 782 VEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQ 841
Query: 340 ----SHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKE 395
+ +W + C+ CGGG+Q C ++V +C N KPKP +
Sbjct: 842 EELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCE---ANKKPKPIRRM 898
Query: 396 CSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCG-GGIQRRSFVCVEESMHGEI 454
C++ C P W W C+ +CG G Q R+ C++ + G
Sbjct: 899 CNIQECTH----------------PLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTN 942
Query: 455 LQVEEWKCMYAPKPKVMQTCNLFDCP-KWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHV 513
V CM +P+ + CN CP +W WS+C+VTCG G R VLC G+H
Sbjct: 943 RSVHSKYCM-GDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLC--RAGDHC 999
Query: 514 GGCNPQ 519
G P+
Sbjct: 1000 DGEKPE 1005
Score = 105 bits (262), Expect = 4e-22
Identities = 57/191 (29%), Positives = 84/191 (43%), Gaps = 17/191 (8%)
Query: 645 TYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCP 704
T++W ++ C+ C GG Q C + V+ S C+ +P + + CN + C
Sbjct: 846 TFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECT 905
Query: 705 -PRWHVGSWGPCSATCG-VGIQTRDVYCLHP----GETPAPPEECRDEKPHALQACNQFD 758
P W W C+ TCG G Q R V CL P + C ++P + + CN+
Sbjct: 906 HPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVP 965
Query: 759 CPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTD 818
CP W W +CS TCG GT+ R+V CR + + C G K S ++C
Sbjct: 966 CPAQWKTGPWSECSVTCGEGTEVRQVLCR-----------AGDHCDGEKPESVRACQLPP 1014
Query: 819 CPPHLAVGDWS 829
C +GD S
Sbjct: 1015 CNDEPCLGDKS 1025
Score = 102 bits (254), Expect = 3e-21
Identities = 60/180 (33%), Positives = 85/180 (47%), Gaps = 17/180 (9%)
Query: 707 WHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEE-CR-DEKPHALQA-CNQFDCP-PG 762
W + SW CS CG G Q C + C ++KP ++ CN +C P
Sbjct: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPL 908
Query: 763 WHIEEWQQCSRTCGG-GTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPP 821
W EEW+ C++TCG G Q R V C Q L DG+ ++ + C G + S + C R CP
Sbjct: 909 WVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPA 968
Query: 822 HLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQMPECS 881
G WS+CSV+CG G + R+ +C+ P S VR+CQ+P C+
Sbjct: 969 QWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPES------------VRACQLPPCN 1016
Score = 94.4 bits (233), Expect = 9e-19
Identities = 81/296 (27%), Positives = 112/296 (37%), Gaps = 73/296 (24%)
Query: 1402 KYILQATNTRT-NSNDPTGEPPPQEPF-WEPGNWSHCSATCGHLGARIQRPQCVM-ANGQ 1458
KYI+ + T NSN+ E + F W +WS CS CG G + + C ++ +
Sbjct: 823 KYIIHEDSVPTINSNNVIQEE--LDTFEWALKSWSQCSKPCGG-GFQYTKYGCRRKSDNK 879
Query: 1459 EVSEALCDHLQKPLAGFEPCNIRDCP-ARWFTSVWSQCSVSCGE-GYHSRQVTCKRTKAN 1516
V + C+ +KP CNI++C W W C+ +CG GY R V C + +
Sbjct: 880 MVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLD 939
Query: 1517 GTVQVVSPRACAPKDRPLGRKPCFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTACQHNSS 1576
GT +R + K C G
Sbjct: 940 GT------------NRSVHSKYCMGD---------------------------------- 953
Query: 1577 DSNCDDRKRPTLRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKR 1636
RP RR C C W TGPW C+ CG G + R+V C A
Sbjct: 954 --------RPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLC--------RAGD 997
Query: 1637 HCVQKKKPISWRHCLGPSC-DRDCT-DTTHYCMFVKHLNLCSLDRYKQRCCQSCQE 1690
HC +KP S R C P C D C D + +C CS+ Y + CC+SC +
Sbjct: 998 HC-DGEKPESVRACQLPPCNDEPCLGDKSIFCQMEVLARYCSIPGYNKLCCESCSK 1052
Score = 79.0 bits (193), Expect = 4e-14
Identities = 58/194 (29%), Positives = 80/194 (41%), Gaps = 39/194 (20%)
Query: 573 WSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEE-CEGPKLPT--ERPCLLEACDESP 629
WS CS CG G Q + CR +++ ++ CE K P R C ++ C
Sbjct: 854 WSQCSKPCGGGFQYTKYGCR-----RKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPL 908
Query: 630 ASRELDIPLPEDSETTYDWEYAGFTPCTATC-VGGHQEAIAVCLHIQ---TQQTVNDSLC 685
E +WE+ CT TC G+Q CL T ++V+ C
Sbjct: 909 WVAE-------------EWEH-----CTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYC 950
Query: 686 DMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRD 745
M RP + + CN PCP +W G W CS TCG G + R V C + C
Sbjct: 951 -MGDRPESR-RPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLC-------RAGDHCDG 1001
Query: 746 EKPHALQACNQFDC 759
EKP +++AC C
Sbjct: 1002 EKPESVRACQLPPC 1015
Score = 58.9 bits (141), Expect = 4e-08
Identities = 67/290 (23%), Positives = 101/290 (34%), Gaps = 73/290 (25%)
Query: 478 DCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKP 537
D +W WSQC+ CG G +Y C + + V C
Sbjct: 845 DTFEWALKSWSQCSKPCGGGFQYTKYGC---------------RRKSDNKMVHRSFCEAN 889
Query: 538 KEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCG-PGVQVREVKCRVLLT 596
K+ P+ ++ ++E P ++ E W C+ TCG G Q+R V+C L
Sbjct: 890 KKPKPI-------RRMCNIQECT----HPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPL- 937
Query: 597 FTQTETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPC 656
T + + C G + + RPC C PA W+ ++ C
Sbjct: 938 LDGTNRSVHSKYCMGDRPESRRPCNRVPC---PA----------------QWKTGPWSEC 978
Query: 657 TATCVGGHQEAIAVCL---HIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWG 713
+ TC G + +C H ++ + C + PP CN EPC G
Sbjct: 979 SVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQL---PP-----CNDEPC--------LG 1022
Query: 714 PCSATCGVGIQTRDVYCLHPGETPAPPEECRDEK-----PHALQACNQFD 758
S C + + R YC PG E C P+ L+A D
Sbjct: 1023 DKSIFCQMEVLAR--YCSIPGYNKLCCESCSKRSSTLPPPYLLEAAETHD 1070
Score = 32.3 bits (72), Expect = 4.0
Identities = 21/67 (31%), Positives = 28/67 (41%), Gaps = 5/67 (7%)
Query: 710 GSW---GPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIE 766
GSW G CS TCG G++ R C +P P + Q CN +C +
Sbjct: 555 GSWTKFGSCSRTCGTGVRFRTRQCNNP--MPINGGQDCPGVNFEYQLCNTEECQKHFEDF 612
Query: 767 EWQQCSR 773
QQC +
Sbjct: 613 RAQQCQQ 619
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 208 bits (529), Expect = 4e-53
Identities = 153/542 (28%), Positives = 235/542 (43%), Gaps = 79/542 (14%)
Query: 74 KDGNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPPDA 127
+DG W +W + CSR+CGGG R C GR C G Y+ C++ +CP
Sbjct: 551 QDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTY 610
Query: 128 EDFRAQQCSAYNDVQ-YQGHYYEWLP-RYNDPAAPCALKCHAQGQNLVVELAPKVLDGTR 185
EDFRAQQC+ N +Q + W+P +D A C L C + VV + V DGTR
Sbjct: 611 EDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTR 670
Query: 186 CN-TDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKRE 244
C+ D +C G C VGCD+++GS +D CGVC GD S CR V+G + S +
Sbjct: 671 CSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKG-TLGKASKQAGA 729
Query: 245 ENVIAVPLGSRSVRITV--KGPAHLFIESKTLQGSKGEHSFNSPGVFLVENT----TVEF 298
++ +P G+R ++I K P + ++++ G N G T +E+
Sbjct: 730 LKLVQIPAGARHIQIEALEKSPHRIVVKNQV----TGSFILNPKGKEATSRTFTAMGLEW 785
Query: 299 QRGSE--RQTFKIPGPL---MADFIFKTRYTAAKDSVV-QFFFYQPI------------- 339
+ E +++ K GPL +A + S+ ++ ++ +
Sbjct: 786 EDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEE 845
Query: 340 --SHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECS 397
+++W + PC+ CGGG Q C R +V H C + +PKP + C+
Sbjct: 846 MDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDH---KKRPKPIRRRCN 902
Query: 398 MDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGG-GIQRRSFVCVEESMHGEILQ 456
PC P W W ACS SCG G+Q R C+ +G +
Sbjct: 903 QHPCSQ----------------PVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNG-THK 945
Query: 457 VEEWKCMYAPKPKVMQTCNLFDCP-KWIAMEWSQCTVTCGRGLRYRVVLCINHRGE--HV 513
V K +P+ + C CP +W WSQC+ TCG G++ R V+C + H
Sbjct: 946 VMPAKACAGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHC 1005
Query: 514 GGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKL--------PWLKQAQELEE-TRIATE 564
G P + C +P C + S V A + W+ Q++ L +I++
Sbjct: 1006 EGDRPD----TVQVCSLP-ACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISST 1060
Query: 565 EP 566
EP
Sbjct: 1061 EP 1062
Score = 118 bits (296), Expect = 4e-26
Identities = 62/181 (34%), Positives = 86/181 (47%), Gaps = 13/181 (7%)
Query: 645 TYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPC- 703
TY+W + PC+ C GG Q C + V LCD RP + + CN PC
Sbjct: 848 TYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCS 907
Query: 704 PPRWHVGSWGPCSATCG-VGIQTRDVYCLHP----GETPAPPEECRDEKPHALQACNQFD 758
P W WG CS +CG +G+QTR + CL P P + C ++P A + C +
Sbjct: 908 QPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVP 967
Query: 759 CPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTD 818
CP W + W QCS TCG G Q R+V CR T+ + L C+G + + + C+
Sbjct: 968 CPAQWRLGAWSQCSATCGEGIQQRQVVCR---TNANSLG----HCEGDRPDTVQVCSLPA 1020
Query: 819 C 819
C
Sbjct: 1021 C 1021
Score = 103 bits (256), Expect = 2e-21
Identities = 53/146 (36%), Positives = 72/146 (49%), Gaps = 5/146 (3%)
Query: 707 WHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHAL---QACNQFDCP-PG 762
W + SW PCS CG GIQ C + D K + CNQ C P
Sbjct: 851 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPV 910
Query: 763 WHIEEWQQCSRTCGG-GTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPP 821
W EEW CSR+CG G Q R + C L++G+ + + C G + + + C R CP
Sbjct: 911 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPA 970
Query: 822 HLAVGDWSKCSVSCGVGIQRRKQVCQ 847
+G WS+CS +CG GIQ+R+ VC+
Sbjct: 971 QWRLGAWSQCSATCGEGIQQRQVVCR 996
Score = 77.4 bits (189), Expect = 1e-13
Identities = 48/119 (40%), Positives = 59/119 (49%), Gaps = 15/119 (12%)
Query: 1422 PPQEPFWEPGNWSHCSATCGHLGARIQRPQCVM--ANG-QEVSEALCDHLQKPLAGFEPC 1478
P +P W W CS +CG LG + + QC++ +NG +V A +P A PC
Sbjct: 905 PCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEAR-RPC 963
Query: 1479 NIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANG----------TVQVVSPRAC 1527
CPA+W WSQCS +CGEG RQV C RT AN TVQV S AC
Sbjct: 964 LRVPCPAQWRLGAWSQCSATCGEGIQQRQVVC-RTNANSLGHCEGDRPDTVQVCSLPAC 1021
Score = 72.0 bits (175), Expect = 5e-12
Identities = 55/189 (29%), Positives = 75/189 (39%), Gaps = 22/189 (11%)
Query: 1487 WFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLG-RKPCFGHPCV 1545
W W+ CS +CG G + C+R + + VQ C K RP R+ C HPC
Sbjct: 851 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQ---RHLCDHKKRPKPIRRRCNQHPCS 907
Query: 1546 Q--W--EPGNRCPGRCMGRAVRMQQRHTAC-------QHNSSDSNCDDRKRPTLRRNCTS 1594
Q W E C C V Q R C H + RP RR C
Sbjct: 908 QPVWVTEEWGACSRSCGKLGV--QTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLR 965
Query: 1595 GACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPS 1654
C W G W C+A CG G Q R+V C + + HC + +P + + C P+
Sbjct: 966 VPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNAN----SLGHC-EGDRPDTVQVCSLPA 1020
Query: 1655 CDRDCTDTT 1663
C + ++T
Sbjct: 1021 CGGNHQNST 1029
Score = 72.0 bits (175), Expect = 5e-12
Identities = 63/249 (25%), Positives = 95/249 (38%), Gaps = 48/249 (19%)
Query: 573 WSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPASR 632
W+ CS CG G+Q + CR + L C+ K P + C++ P S+
Sbjct: 856 WAPCSKACGGGIQFTKYGCRRRRDHHMVQRHL----CDHKKRPKP---IRRRCNQHPCSQ 908
Query: 633 ELDIPLPEDSETTYDWEYAGFTPCTATC--VGGHQEAIAVCLHIQ--TQQTVNDSLCDMV 688
+ W + C+ +C +G I L + T + + C
Sbjct: 909 PV-------------WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKAC--A 953
Query: 689 HRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKP 748
P + C PCP +W +G+W CSATCG GIQ R V C + C ++P
Sbjct: 954 GDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLG---HCEGDRP 1010
Query: 749 HALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNR--RVTCRQLLT-DGSFLNLSDELCQG 805
+Q C+ CGG QN R +L T +G ++ S+ L
Sbjct: 1011 DTVQVCS----------------LPACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPI 1054
Query: 806 PKASSHKSC 814
K SS + C
Sbjct: 1055 NKISSTEPC 1063
Score = 70.9 bits (172), Expect = 1e-11
Identities = 68/304 (22%), Positives = 110/304 (36%), Gaps = 81/304 (26%)
Query: 478 DCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKP 537
D +W W+ C+ CG G+++ C R H+ ++ H+ C
Sbjct: 847 DTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHM------VQRHL---------CDHK 891
Query: 538 KEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGP-GVQVREVKCRVLLT 596
K P+ + + +P ++ E W ACS +CG GVQ R ++C + L+
Sbjct: 892 KRPKPIRRRC-----------NQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLS 940
Query: 597 FTQTETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPC 656
T +P + C G + RPCL C PA W ++ C
Sbjct: 941 -NGTHKVMPAKACAGDRPEARRPCLRVPC---PA----------------QWRLGAWSQC 980
Query: 657 TATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPR---------- 706
+ATC G Q+ VC +T +SL P Q C+ C
Sbjct: 981 SATCGEGIQQRQVVC------RTNANSLGHCEGDRPDTVQVCSLPACGGNHQNSTVRADV 1034
Query: 707 WHVGS----WGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKP--HALQACNQFDCP 760
W +G+ W P S LHP + E C ++ ++ +++
Sbjct: 1035 WELGTPEGQWVPQSEP------------LHPINKISSTEPCTGDRSVFCQMEVLDRYCSI 1082
Query: 761 PGWH 764
PG+H
Sbjct: 1083 PGYH 1086
Score = 50.1 bits (118), Expect = 2e-05
Identities = 33/115 (28%), Positives = 48/115 (41%), Gaps = 17/115 (14%)
Query: 1580 CDDRKRPT-LRRNCTSGACDV-CWHTGPWKPCTAACGR-GFQSRKVDCI----------- 1625
CD +KRP +RR C C W T W C+ +CG+ G Q+R + C+
Sbjct: 888 CDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVM 947
Query: 1626 HTRSC---KPVAKRHCVQKKKPISWRHCLGPSCDRDCTDTTHYCMFVKHLNLCSL 1677
++C +P A+R C++ P WR C C + V N SL
Sbjct: 948 PAKACAGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSL 1002
Score = 34.7 bits (78), Expect = 0.81
Identities = 19/62 (30%), Positives = 30/62 (48%), Gaps = 2/62 (3%)
Query: 712 WGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQQC 771
+G CS +CG G+++R C +P +PA Q CN +CP + QQC
Sbjct: 561 FGSCSRSCGGGVRSRSRSCNNP--SPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQC 618
Query: 772 SR 773
++
Sbjct: 619 AK 620
Score = 32.0 bits (71), Expect = 5.2
Identities = 34/139 (24%), Positives = 49/139 (35%), Gaps = 46/139 (33%)
Query: 715 CSATCGVGIQT----------RDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPG-- 762
C G G QT + ++C HP P C+ +K L +C PG
Sbjct: 482 CRFDFGSGYQTCLAFRTFEPCKQLWCSHPDN----PYFCKTKKGPPLDGT---ECAPGKW 534
Query: 763 -------WHIEE-----------WQQ---CSRTCGGGTQNRRVTCRQLLTDGSFLNLSDE 801
W E W + CSR+CGGG ++R +C +
Sbjct: 535 CFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSC-----NNPSPAYGGR 589
Query: 802 LCQGPKASSHKSCARTDCP 820
LC GP ++ C +CP
Sbjct: 590 LCLGP-MFEYQVCNSEECP 607
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 208 bits (529), Expect = 4e-53
Identities = 153/542 (28%), Positives = 235/542 (43%), Gaps = 79/542 (14%)
Query: 74 KDGNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPPDA 127
+DG W +W + CSR+CGGG R C GR C G Y+ C++ +CP
Sbjct: 554 QDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTY 613
Query: 128 EDFRAQQCSAYNDVQ-YQGHYYEWLP-RYNDPAAPCALKCHAQGQNLVVELAPKVLDGTR 185
EDFRAQQC+ N +Q + W+P +D A C L C + VV + V DGTR
Sbjct: 614 EDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTR 673
Query: 186 CN-TDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKRE 244
C+ D +C G C VGCD+++GS +D CGVC GD S CR V+G + S +
Sbjct: 674 CSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKG-TLGKASKQAGA 732
Query: 245 ENVIAVPLGSRSVRITV--KGPAHLFIESKTLQGSKGEHSFNSPGVFLVENT----TVEF 298
++ +P G+R ++I K P + ++++ G N G T +E+
Sbjct: 733 LKLVQIPAGARHIQIEALEKSPHRIVVKNQV----TGSFILNPKGKEATSRTFTAMGLEW 788
Query: 299 QRGSE--RQTFKIPGPL---MADFIFKTRYTAAKDSVV-QFFFYQPI------------- 339
+ E +++ K GPL +A + S+ ++ ++ +
Sbjct: 789 EDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEE 848
Query: 340 --SHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECS 397
+++W + PC+ CGGG Q C R +V H C + +PKP + C+
Sbjct: 849 MDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDH---KKRPKPIRRRCN 905
Query: 398 MDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGG-GIQRRSFVCVEESMHGEILQ 456
PC P W W ACS SCG G+Q R C+ +G +
Sbjct: 906 QHPCSQ----------------PVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNG-THK 948
Query: 457 VEEWKCMYAPKPKVMQTCNLFDCP-KWIAMEWSQCTVTCGRGLRYRVVLCINHRGE--HV 513
V K +P+ + C CP +W WSQC+ TCG G++ R V+C + H
Sbjct: 949 VMPAKACAGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHC 1008
Query: 514 GGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKL--------PWLKQAQELEE-TRIATE 564
G P + C +P C + S V A + W+ Q++ L +I++
Sbjct: 1009 EGDRPD----TVQVCSLP-ACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISST 1063
Query: 565 EP 566
EP
Sbjct: 1064 EP 1065
Score = 118 bits (296), Expect = 4e-26
Identities = 62/181 (34%), Positives = 86/181 (47%), Gaps = 13/181 (7%)
Query: 645 TYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPC- 703
TY+W + PC+ C GG Q C + V LCD RP + + CN PC
Sbjct: 851 TYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCS 910
Query: 704 PPRWHVGSWGPCSATCG-VGIQTRDVYCLHP----GETPAPPEECRDEKPHALQACNQFD 758
P W WG CS +CG +G+QTR + CL P P + C ++P A + C +
Sbjct: 911 QPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVP 970
Query: 759 CPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTD 818
CP W + W QCS TCG G Q R+V CR T+ + L C+G + + + C+
Sbjct: 971 CPAQWRLGAWSQCSATCGEGIQQRQVVCR---TNANSLG----HCEGDRPDTVQVCSLPA 1023
Query: 819 C 819
C
Sbjct: 1024 C 1024
Score = 103 bits (256), Expect = 2e-21
Identities = 53/146 (36%), Positives = 72/146 (49%), Gaps = 5/146 (3%)
Query: 707 WHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHAL---QACNQFDCP-PG 762
W + SW PCS CG GIQ C + D K + CNQ C P
Sbjct: 854 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPV 913
Query: 763 WHIEEWQQCSRTCGG-GTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPP 821
W EEW CSR+CG G Q R + C L++G+ + + C G + + + C R CP
Sbjct: 914 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPA 973
Query: 822 HLAVGDWSKCSVSCGVGIQRRKQVCQ 847
+G WS+CS +CG GIQ+R+ VC+
Sbjct: 974 QWRLGAWSQCSATCGEGIQQRQVVCR 999
Score = 77.4 bits (189), Expect = 1e-13
Identities = 48/119 (40%), Positives = 59/119 (49%), Gaps = 15/119 (12%)
Query: 1422 PPQEPFWEPGNWSHCSATCGHLGARIQRPQCVM--ANG-QEVSEALCDHLQKPLAGFEPC 1478
P +P W W CS +CG LG + + QC++ +NG +V A +P A PC
Sbjct: 908 PCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEAR-RPC 966
Query: 1479 NIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANG----------TVQVVSPRAC 1527
CPA+W WSQCS +CGEG RQV C RT AN TVQV S AC
Sbjct: 967 LRVPCPAQWRLGAWSQCSATCGEGIQQRQVVC-RTNANSLGHCEGDRPDTVQVCSLPAC 1024
Score = 72.0 bits (175), Expect = 5e-12
Identities = 55/189 (29%), Positives = 75/189 (39%), Gaps = 22/189 (11%)
Query: 1487 WFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLG-RKPCFGHPCV 1545
W W+ CS +CG G + C+R + + VQ C K RP R+ C HPC
Sbjct: 854 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQ---RHLCDHKKRPKPIRRRCNQHPCS 910
Query: 1546 Q--W--EPGNRCPGRCMGRAVRMQQRHTAC-------QHNSSDSNCDDRKRPTLRRNCTS 1594
Q W E C C V Q R C H + RP RR C
Sbjct: 911 QPVWVTEEWGACSRSCGKLGV--QTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLR 968
Query: 1595 GACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPS 1654
C W G W C+A CG G Q R+V C + + HC + +P + + C P+
Sbjct: 969 VPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNAN----SLGHC-EGDRPDTVQVCSLPA 1023
Query: 1655 CDRDCTDTT 1663
C + ++T
Sbjct: 1024 CGGNHQNST 1032
Score = 72.0 bits (175), Expect = 5e-12
Identities = 63/249 (25%), Positives = 95/249 (38%), Gaps = 48/249 (19%)
Query: 573 WSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPASR 632
W+ CS CG G+Q + CR + L C+ K P + C++ P S+
Sbjct: 859 WAPCSKACGGGIQFTKYGCRRRRDHHMVQRHL----CDHKKRPKP---IRRRCNQHPCSQ 911
Query: 633 ELDIPLPEDSETTYDWEYAGFTPCTATC--VGGHQEAIAVCLHIQ--TQQTVNDSLCDMV 688
+ W + C+ +C +G I L + T + + C
Sbjct: 912 PV-------------WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKAC--A 956
Query: 689 HRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKP 748
P + C PCP +W +G+W CSATCG GIQ R V C + C ++P
Sbjct: 957 GDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLG---HCEGDRP 1013
Query: 749 HALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNR--RVTCRQLLT-DGSFLNLSDELCQG 805
+Q C+ CGG QN R +L T +G ++ S+ L
Sbjct: 1014 DTVQVCS----------------LPACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPI 1057
Query: 806 PKASSHKSC 814
K SS + C
Sbjct: 1058 NKISSTEPC 1066
Score = 70.9 bits (172), Expect = 1e-11
Identities = 68/304 (22%), Positives = 110/304 (36%), Gaps = 81/304 (26%)
Query: 478 DCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKP 537
D +W W+ C+ CG G+++ C R H+ ++ H+ C
Sbjct: 850 DTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHM------VQRHL---------CDHK 894
Query: 538 KEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGP-GVQVREVKCRVLLT 596
K P+ + + +P ++ E W ACS +CG GVQ R ++C + L+
Sbjct: 895 KRPKPIRRRC-----------NQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLS 943
Query: 597 FTQTETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPC 656
T +P + C G + RPCL C PA W ++ C
Sbjct: 944 -NGTHKVMPAKACAGDRPEARRPCLRVPC---PA----------------QWRLGAWSQC 983
Query: 657 TATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPR---------- 706
+ATC G Q+ VC +T +SL P Q C+ C
Sbjct: 984 SATCGEGIQQRQVVC------RTNANSLGHCEGDRPDTVQVCSLPACGGNHQNSTVRADV 1037
Query: 707 WHVGS----WGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKP--HALQACNQFDCP 760
W +G+ W P S LHP + E C ++ ++ +++
Sbjct: 1038 WELGTPEGQWVPQSEP------------LHPINKISSTEPCTGDRSVFCQMEVLDRYCSI 1085
Query: 761 PGWH 764
PG+H
Sbjct: 1086 PGYH 1089
Score = 50.1 bits (118), Expect = 2e-05
Identities = 33/115 (28%), Positives = 48/115 (41%), Gaps = 17/115 (14%)
Query: 1580 CDDRKRPT-LRRNCTSGACDV-CWHTGPWKPCTAACGR-GFQSRKVDCI----------- 1625
CD +KRP +RR C C W T W C+ +CG+ G Q+R + C+
Sbjct: 891 CDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVM 950
Query: 1626 HTRSC---KPVAKRHCVQKKKPISWRHCLGPSCDRDCTDTTHYCMFVKHLNLCSL 1677
++C +P A+R C++ P WR C C + V N SL
Sbjct: 951 PAKACAGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSL 1005
Score = 34.7 bits (78), Expect = 0.81
Identities = 19/62 (30%), Positives = 30/62 (48%), Gaps = 2/62 (3%)
Query: 712 WGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQQC 771
+G CS +CG G+++R C +P +PA Q CN +CP + QQC
Sbjct: 564 FGSCSRSCGGGVRSRSRSCNNP--SPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQC 621
Query: 772 SR 773
++
Sbjct: 622 AK 623
Score = 32.0 bits (71), Expect = 5.2
Identities = 34/139 (24%), Positives = 49/139 (35%), Gaps = 46/139 (33%)
Query: 715 CSATCGVGIQT----------RDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPG-- 762
C G G QT + ++C HP P C+ +K L +C PG
Sbjct: 485 CRFDFGSGYQTCLAFRTFEPCKQLWCSHPDN----PYFCKTKKGPPLDGT---ECAPGKW 537
Query: 763 -------WHIEE-----------WQQ---CSRTCGGGTQNRRVTCRQLLTDGSFLNLSDE 801
W E W + CSR+CGGG ++R +C +
Sbjct: 538 CFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSC-----NNPSPAYGGR 592
Query: 802 LCQGPKASSHKSCARTDCP 820
LC GP ++ C +CP
Sbjct: 593 LCLGP-MFEYQVCNSEECP 610
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
type) with thrombospondin type 1 motif, 15 preproprotein
[Homo sapiens]
Length = 950
Score = 200 bits (508), Expect = 1e-50
Identities = 144/484 (29%), Positives = 210/484 (43%), Gaps = 73/484 (15%)
Query: 75 DGNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPPDA- 127
DG+W W + CSRTCGGG + R+C G+ CEG ++Y++C+ CP A
Sbjct: 516 DGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSAS 575
Query: 128 -EDFRAQQCSAYNDVQYQGHYYE----WLPRYN--DPAAPCALKCHAQGQNLVVELAPKV 180
+ FR +QC A+N + + W+P+Y+ P C L C A G LAPKV
Sbjct: 576 GKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKV 635
Query: 181 LDGTRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSP 240
+DGT C+ DS +C+ G C GCD LGS + D CGVC GD +C+ V G P
Sbjct: 636 VDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGL---FTKP 692
Query: 241 EKREENVIAVPLGSRSVRITVKGPAHLFIESK--TLQGSKGEHSFNSPGVFLVENTTVEF 298
V+A+P G+ S+ I +G L + L+ S+G++ N G F+V
Sbjct: 693 MHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLN--GHFVVS------ 744
Query: 299 QRGSERQTFKIPGPLMADFIFKTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGG 358
+ + + G L+ RY+ +V +PI P TV
Sbjct: 745 ---AVERDLVVKGSLL-------RYSGTGTAVESLQASRPILE--------PLTVEV--- 783
Query: 359 YQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHF-- 416
L+ + R++ Y Y P+ +P+ DP S ++ +
Sbjct: 784 --LSVGKMTPPRVR------YSFYLPK--EPREDKSSHPKDPRGPSVLHNSVLSLSNQVE 833
Query: 417 ----QPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQ 472
+P RW W CS SCG G+Q+R+ C G Q C A +P Q
Sbjct: 834 QPDDRPPARWVAGSWGPCSASCGSGLQKRAVDC-----RGSAGQRTVPACDAAHRPVETQ 888
Query: 473 TCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVG--GCNPQLKLHIKEECVI 530
C CP W WS C+ +CGRG + R + C+ H G + CN K + CV+
Sbjct: 889 ACGE-PCPTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVL 947
Query: 531 PIPC 534
PC
Sbjct: 948 R-PC 950
Score = 73.9 bits (180), Expect = 1e-12
Identities = 35/83 (42%), Positives = 43/83 (51%), Gaps = 2/83 (2%)
Query: 704 PPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGW 763
P RW GSWGPCSA+CG G+Q R V C P +P QAC + CP W
Sbjct: 840 PARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGE-PCPT-W 897
Query: 764 HIEEWQQCSRTCGGGTQNRRVTC 786
+ W CS++CG G Q R + C
Sbjct: 898 ELSAWSPCSKSCGRGFQRRSLKC 920
Score = 72.8 bits (177), Expect = 3e-12
Identities = 49/152 (32%), Positives = 66/152 (43%), Gaps = 7/152 (4%)
Query: 604 LPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGG 663
LP+E E + P S S + P+D W + PC+A+C G
Sbjct: 800 LPKEPREDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPPAR-WVAGSWGPCSASCGSG 858
Query: 664 HQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGI 723
Q+ C Q+TV CD HRP +QAC EPCP W + +W PCS +CG G
Sbjct: 859 LQKRAVDCRGSAGQRTV--PACDAAHRP-VETQACG-EPCPT-WELSAWSPCSKSCGRGF 913
Query: 724 QTRDVYCLHPGETPAPPEECR-DEKPHALQAC 754
Q R + C+ G ++C KP L C
Sbjct: 914 QRRSLKCVGHGGRLLARDQCNLHRKPQELDFC 945
Score = 57.4 bits (137), Expect = 1e-07
Identities = 35/97 (36%), Positives = 45/97 (46%), Gaps = 14/97 (14%)
Query: 1417 PTGEPPPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPL---A 1473
P PP + W G+W CSA+CG G + + C + GQ A CD +P+ A
Sbjct: 835 PDDRPPAR---WVAGSWGPCSASCGS-GLQKRAVDCRGSAGQRTVPA-CDAAHRPVETQA 889
Query: 1474 GFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTC 1510
EPC W S WS CS SCG G+ R + C
Sbjct: 890 CGEPC------PTWELSAWSPCSKSCGRGFQRRSLKC 920
Score = 54.3 bits (129), Expect = 1e-06
Identities = 34/103 (33%), Positives = 42/103 (40%), Gaps = 19/103 (18%)
Query: 1484 PARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHP 1543
PARW W CS SCG G R V C+ + TV AC RP+ + C G P
Sbjct: 840 PARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVP-----ACDAAHRPVETQAC-GEP 893
Query: 1544 CVQWE-----PGNRCPGR--------CMGRAVRMQQRHTACQH 1573
C WE P ++ GR C+G R+ R H
Sbjct: 894 CPTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLH 936
Score = 52.0 bits (123), Expect = 5e-06
Identities = 32/90 (35%), Positives = 35/90 (38%), Gaps = 7/90 (7%)
Query: 758 DCPPG-WHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCAR 816
D PP W W CS +CG G Q R V CR GS + C
Sbjct: 837 DRPPARWVAGSWGPCSASCGSGLQKRAVDCR-----GSAGQRTVPACDAAHRPVETQACG 891
Query: 817 TDCPPHLAVGDWSKCSVSCGVGIQRRKQVC 846
CP + WS CS SCG G QRR C
Sbjct: 892 EPCPT-WELSAWSPCSKSCGRGFQRRSLKC 920
Score = 49.3 bits (116), Expect = 3e-05
Identities = 38/145 (26%), Positives = 58/145 (40%), Gaps = 21/145 (14%)
Query: 1516 NGTVQVVSPRACAPKDRPLGRKPCFGHPCVQWEPGN--RCPGRCMGRAVRMQQRHTACQH 1573
+ +V +S + P DRP R W G+ C C +Q+R C+
Sbjct: 822 HNSVLSLSNQVEQPDDRPPAR----------WVAGSWGPCSASC---GSGLQKRAVDCRG 868
Query: 1574 NSSDSN---CDDRKRPTLRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSC 1630
++ CD RP + C G W W PC+ +CGRGFQ R + C+
Sbjct: 869 SAGQRTVPACDAAHRPVETQAC--GEPCPTWELSAWSPCSKSCGRGFQRRSLKCV-GHGG 925
Query: 1631 KPVAKRHCVQKKKPISWRHCLGPSC 1655
+ +A+ C +KP C+ C
Sbjct: 926 RLLARDQCNLHRKPQELDFCVLRPC 950
Score = 46.6 bits (109), Expect = 2e-04
Identities = 37/147 (25%), Positives = 52/147 (35%), Gaps = 40/147 (27%)
Query: 481 KWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEK 540
+W+A W C+ +CG GL+ R V C G+
Sbjct: 842 RWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRT--------------------------- 874
Query: 541 SPVEAKLPWLKQAQELEETRIATEE-PTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQ 599
+P A ET+ E PT+ WS CS +CG G Q R +KC
Sbjct: 875 ------VPACDAAHRPVETQACGEPCPTWELSAWSPCSKSCGRGFQRRSLKC-----VGH 923
Query: 600 TETELPEEECEGPKLPTERP-CLLEAC 625
L ++C + P E C+L C
Sbjct: 924 GGRLLARDQCNLHRKPQELDFCVLRPC 950
Score = 46.2 bits (108), Expect = 3e-04
Identities = 35/131 (26%), Positives = 50/131 (38%), Gaps = 28/131 (21%)
Query: 573 WSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPASR 632
W CS +CG G+Q R V CR + + C+ RP +AC E
Sbjct: 848 WGPCSASCGSGLQKRAVDCR------GSAGQRTVPACDA----AHRPVETQACGE----- 892
Query: 633 ELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPP 692
P P WE + ++PC+ +C G Q C+ + D C++ HR P
Sbjct: 893 ----PCP-------TWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQ-CNL-HRKP 939
Query: 693 AMSQACNTEPC 703
C PC
Sbjct: 940 QELDFCVLRPC 950
Score = 38.9 bits (89), Expect = 0.043
Identities = 23/67 (34%), Positives = 34/67 (50%), Gaps = 9/67 (13%)
Query: 339 ISHQWRQTD-FFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECS 397
+ W + D + PC+ TCGGG QL +C + YC E V + K + C+
Sbjct: 515 VDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPAN--GGKYC----EGV--RVKYRSCN 566
Query: 398 MDPCPSS 404
++PCPSS
Sbjct: 567 LEPCPSS 573
Score = 35.8 bits (81), Expect = 0.36
Identities = 28/85 (32%), Positives = 36/85 (42%), Gaps = 12/85 (14%)
Query: 710 GSW------GPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCP--- 760
GSW GPCS TCG G+Q C +P TPA + + ++CN CP
Sbjct: 517 GSWAKWDPYGPCSRTCGGGVQLARRQCTNP--TPANGGKYCEGVRVKYRSCNLEPCPSSA 574
Query: 761 PGWHIEEWQQCSRTCGGGTQNRRVT 785
G E +QC G R+T
Sbjct: 575 SGKSFRE-EQCEAFNGYNHSTNRLT 598
Score = 34.3 bits (77), Expect = 1.1
Identities = 16/38 (42%), Positives = 20/38 (52%), Gaps = 1/38 (2%)
Query: 820 PPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIP 857
P G W CS SCG G+Q+R C R +A R +P
Sbjct: 840 PARWVAGSWGPCSASCGSGLQKRAVDC-RGSAGQRTVP 876
Score = 33.9 bits (76), Expect = 1.4
Identities = 20/62 (32%), Positives = 29/62 (46%), Gaps = 7/62 (11%)
Query: 571 EPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPA 630
+P+ CS TCG GVQ+ +C T + CEG ++ R C LE C S +
Sbjct: 523 DPYGPCSRTCGGGVQLARRQC------TNPTPANGGKYCEGVRV-KYRSCNLEPCPSSAS 575
Query: 631 SR 632
+
Sbjct: 576 GK 577
Score = 32.7 bits (73), Expect = 3.1
Identities = 30/103 (29%), Positives = 40/103 (38%), Gaps = 25/103 (24%)
Query: 1534 LGRKPCFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCT 1593
+G KPC P +Q+ C G+ G+ V Q RH +S C + K C
Sbjct: 454 VGSKPC---PYMQYCTKLWCTGKAKGQMV-CQTRHFPWADGTS---CGEGKL------CL 500
Query: 1594 SGAC-----------DVCWHT-GPWKPCTAACGRGFQSRKVDC 1624
GAC D W P+ PC+ CG G Q + C
Sbjct: 501 KGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQC 543
Score = 32.0 bits (71), Expect = 5.2
Identities = 19/50 (38%), Positives = 26/50 (52%), Gaps = 6/50 (12%)
Query: 771 CSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCP 820
CSRTCGGG Q R C T+ + N + C+G + ++SC CP
Sbjct: 528 CSRTCGGGVQLARRQC----TNPTPAN-GGKYCEGVRV-KYRSCNLEPCP 571
Score = 31.6 bits (70), Expect = 6.8
Identities = 20/80 (25%), Positives = 34/80 (42%), Gaps = 4/80 (5%)
Query: 32 AYFLPEFALSPQGSFLEDTTGEQFLTYRYDDQTSRNTRSDEDKDGNWDAWGDWSDCSRTC 91
+++LP+ + S +D G L +++ + D+ W A G W CS +C
Sbjct: 797 SFYLPKEPREDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPPARWVA-GSWGPCSASC 855
Query: 92 GGGASYSLRRCLTGRNCEGQ 111
G G +R + R GQ
Sbjct: 856 GSGLQ---KRAVDCRGSAGQ 872
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
1 preproprotein [Homo sapiens]
Length = 967
Score = 199 bits (507), Expect = 1e-50
Identities = 133/465 (28%), Positives = 206/465 (44%), Gaps = 90/465 (19%)
Query: 76 GNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPPD-AE 128
G+W WG W DCSRTCGGG Y++R C G+ CEG+ +RY++C+ DCP + +
Sbjct: 560 GSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGK 619
Query: 129 DFRAQQCSAYNDVQY----QGHYYEWLPRYN--DPAAPCALKCHAQGQNLVVELAPKVLD 182
FR +QC A+N+ G EW+P+Y P C L C A+G L PKV+D
Sbjct: 620 TFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVD 679
Query: 183 GTRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEK 242
GT C+ DS +C+ G C GCDR + S K D CGVC G+GSTC+ + G S S +
Sbjct: 680 GTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISG---SVTSAKP 736
Query: 243 REENVIAVPLGSRSVRITVKGPAHLFIESKTLQGSKGEHSF----NSPGVFLVENTTVEF 298
++I +P G+ ++ + + + +GS+ SF + G +++ ++
Sbjct: 737 GYHDIITIPTGATNIEV----------KQRNQRGSRNNGSFLAIKAADGTYILNG---DY 783
Query: 299 QRGSERQTFKIPGPLMADFIFKTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGG 358
+ Q G ++ RY+ + ++ + + P+ P T+
Sbjct: 784 TLSTLEQDIMYKGVVL-------RYSGSSAALERIRSFSPLKE--------PLTIQV--- 825
Query: 359 YQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQP 418
L + ++K Y VK K + F I +
Sbjct: 826 --LTVGNALRPKIK----------YTYFVKKK-------------KESFNAIPTFS---- 856
Query: 419 LPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFD 478
W W CS SC G QRR C ++G+ +C KP + C
Sbjct: 857 --AWVIEEWGECSKSCELGWQRRLVEC--RDINGQPAS----ECAKEVKPASTRPCADHP 908
Query: 479 CPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVG--GCNPQLK 521
CP+W EWS C+ TCG+G + R + C++H G + C+P K
Sbjct: 909 CPQWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKK 953
Score = 70.9 bits (172), Expect = 1e-11
Identities = 45/127 (35%), Positives = 57/127 (44%), Gaps = 10/127 (7%)
Query: 696 QACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDE-KPHALQAC 754
++ N P W + WG CS +C +G Q R V C PA EC E KP + + C
Sbjct: 847 ESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPA--SECAKEVKPASTRPC 904
Query: 755 NQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSH--K 812
CP W + EW CS+TCG G + R + C L DG LS E C K H
Sbjct: 905 ADHPCPQ-WQLGEWSSCSKTCGKGYKKRSLKC--LSHDGGV--LSHESCDPLKKPKHFID 959
Query: 813 SCARTDC 819
C +C
Sbjct: 960 FCTMAEC 966
Score = 62.0 bits (149), Expect = 5e-09
Identities = 43/120 (35%), Positives = 59/120 (49%), Gaps = 11/120 (9%)
Query: 763 WHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPH 822
W IEEW +CS++C G Q R V CR + +G + E + K +S + CA C P
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDI--NG---QPASECAKEVKPASTRPCADHPC-PQ 911
Query: 823 LAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDL-PGLPLVRSCQMPECS 881
+G+WS CS +CG G ++R C L+ G LS C L + C M ECS
Sbjct: 912 WQLGEWSSCSKTCGKGYKKRSLKC--LSHDGG--VLSHESCDPLKKPKHFIDFCTMAECS 967
Score = 59.3 bits (142), Expect = 3e-08
Identities = 37/106 (34%), Positives = 48/106 (45%), Gaps = 9/106 (8%)
Query: 1428 WEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARW 1487
W W CS +C LG + + +C NGQ SE C KP A PC CP +W
Sbjct: 858 WVIEEWGECSKSC-ELGWQRRLVECRDINGQPASE--CAKEVKP-ASTRPCADHPCP-QW 912
Query: 1488 FTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRP 1533
WS CS +CG+GY R + C V+S +C P +P
Sbjct: 913 QLGEWSSCSKTCGKGYKKRSLKCLSHDGG----VLSHESCDPLKKP 954
Score = 55.8 bits (133), Expect = 3e-07
Identities = 35/114 (30%), Positives = 49/114 (42%), Gaps = 7/114 (6%)
Query: 648 WEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRW 707
W + C+ +C G Q + C I Q S C +P A ++ C PCP +W
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPA---SECAKEVKP-ASTRPCADHPCP-QW 912
Query: 708 HVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRD-EKP-HALQACNQFDC 759
+G W CS TCG G + R + CL E C +KP H + C +C
Sbjct: 913 QLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAEC 966
Score = 53.1 bits (126), Expect = 2e-06
Identities = 31/106 (29%), Positives = 46/106 (43%), Gaps = 15/106 (14%)
Query: 1487 WFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPCVQ 1546
W W +CS SC G+ R V C+ + CA + +P +PC HPC Q
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPASE------CAKEVKPASTRPCADHPCPQ 911
Query: 1547 WEPG--NRCPGRCMGRAVRMQQRHTACQHNS----SDSNCDDRKRP 1586
W+ G + C C G+ + +R C + S +CD K+P
Sbjct: 912 WQLGEWSSCSKTC-GKGYK--KRSLKCLSHDGGVLSHESCDPLKKP 954
Score = 46.2 bits (108), Expect = 3e-04
Identities = 25/77 (32%), Positives = 38/77 (49%), Gaps = 3/77 (3%)
Query: 1407 ATNTRTNSNDPTGEPPPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCD 1466
A + S P + P P W+ G WS CS TCG G + + +C+ +G +S CD
Sbjct: 893 AKEVKPASTRPCADHPC--PQWQLGEWSSCSKTCGK-GYKKRSLKCLSHDGGVLSHESCD 949
Query: 1467 HLQKPLAGFEPCNIRDC 1483
L+KP + C + +C
Sbjct: 950 PLKKPKHFIDFCTMAEC 966
Score = 42.7 bits (99), Expect = 0.003
Identities = 37/142 (26%), Positives = 54/142 (38%), Gaps = 32/142 (22%)
Query: 566 PTF---IPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLP-TERPCL 621
PTF + E W CS +C G Q R V+CR + P EC P + RPC
Sbjct: 853 PTFSAWVIEEWGECSKSCELGWQRRLVECRDI-------NGQPASECAKEVKPASTRPC- 904
Query: 622 LEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVN 681
D P P+ W+ ++ C+ TC G+++ CL +
Sbjct: 905 ------------ADHPCPQ-------WQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSH 945
Query: 682 DSLCDMVHRPPAMSQACNTEPC 703
+S CD + +P C C
Sbjct: 946 ES-CDPLKKPKHFIDFCTMAEC 966
Score = 42.7 bits (99), Expect = 0.003
Identities = 22/80 (27%), Positives = 33/80 (41%), Gaps = 10/80 (12%)
Query: 1565 QQRHTACQ--HNSSDSNCDDRKRPTLRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKV 1622
Q+R C+ + S C +P R C C W G W C+ CG+G++ R +
Sbjct: 875 QRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQ-WQLGEWSSCSKTCGKGYKKRSL 933
Query: 1623 DC-------IHTRSCKPVAK 1635
C + SC P+ K
Sbjct: 934 KCLSHDGGVLSHESCDPLKK 953
Score = 37.7 bits (86), Expect = 0.095
Identities = 20/53 (37%), Positives = 24/53 (45%), Gaps = 6/53 (11%)
Query: 768 WQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCP 820
W CSRTCGGG Q C D + C+G K ++SC DCP
Sbjct: 568 WGDCSRTCGGGVQYTMREC-----DNPVPKNGGKYCEG-KRVRYRSCNLEDCP 614
Score = 37.0 bits (84), Expect = 0.16
Identities = 19/53 (35%), Positives = 26/53 (49%), Gaps = 6/53 (11%)
Query: 710 GSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECR--DEKPHALQACNQFDCP 760
G WG CS TCG G+Q Y + + P P + + K ++CN DCP
Sbjct: 566 GPWGDCSRTCGGGVQ----YTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCP 614
Score = 34.3 bits (77), Expect = 1.1
Identities = 17/55 (30%), Positives = 23/55 (41%), Gaps = 3/55 (5%)
Query: 1601 WHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSC 1655
W W C+ +C G+Q R V+C R C ++ KP S R C C
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVEC---RDINGQPASECAKEVKPASTRPCADHPC 909
Score = 33.5 bits (75), Expect = 1.8
Identities = 20/60 (33%), Positives = 29/60 (48%), Gaps = 13/60 (21%)
Query: 572 PWSACSTTCGPGVQVREVKCRVLLTFTQTETELPE---EECEGPKLPTERPCLLEACDES 628
PW CS TCG GVQ T + + +P+ + CEG ++ R C LE C ++
Sbjct: 567 PWGDCSRTCGGGVQ---------YTMRECDNPVPKNGGKYCEGKRV-RYRSCNLEDCPDN 616
Score = 32.7 bits (73), Expect = 3.1
Identities = 16/49 (32%), Positives = 25/49 (51%), Gaps = 3/49 (6%)
Query: 82 GDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDF 130
G+WS CS+TCG G +CL+ +G + +++C P DF
Sbjct: 915 GEWSSCSKTCGKGYKKRSLKCLSH---DGGVLSHESCDPLKKPKHFIDF 960
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 199 bits (506), Expect = 2e-50
Identities = 138/465 (29%), Positives = 202/465 (43%), Gaps = 55/465 (11%)
Query: 74 KDGNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPPDA 127
+DG+W AW + CSRTCG G + R+C GR C G ++ CS DCP
Sbjct: 560 RDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSL 619
Query: 128 EDFRAQQCSAYNDVQYQGH-YYEWLPR-YNDPAAPCALKCHAQGQNLVVELAPKVLDGTR 185
DFR +QC ++ G + WLP + D C L C ++ VV + V DGTR
Sbjct: 620 ADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYCESRETGEVVSMKRMVHDGTR 679
Query: 186 CN-TDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKRE 244
C+ D+ +C+ G C+ VGCD +GS+ +ED CGVC GD S C++V+G SP+K
Sbjct: 680 CSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTR--SPKKHG 737
Query: 245 E-NVIAVPLGSRSVRITVKGPAHLFIESKTLQGSK----GEHSFN-SPGVFLVENTTVEF 298
+ +P G+R + I + K L+ K E+ + S F+ E+
Sbjct: 738 YIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGVEWEY 797
Query: 299 QRGSERQTFKIPGPLMADFI------------FKTRYTAAKDSV----VQFFFYQPISHQ 342
+ R+T + GPL +Y +DS+ + ++
Sbjct: 798 RDEDGRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYE 857
Query: 343 WRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCP 402
W + PC+ CGGG Q C ++V +C KPK + C+ C
Sbjct: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALS---KPKAIRRACNPQECS 914
Query: 403 SSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCG-GGIQRRSFVCVEESMHGEILQVEEWK 461
P W W CS +CG G+Q RS C++ V
Sbjct: 915 Q----------------PVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKH 958
Query: 462 CMYAPKPKVMQTCNLFDCP-KWIAMEWSQCTVTCGRGLRYRVVLC 505
C A +P+ + C+ CP +W A WSQC+VTCG G + R VLC
Sbjct: 959 CNDA-RPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLC 1002
Score = 93.6 bits (231), Expect = 1e-18
Identities = 55/152 (36%), Positives = 74/152 (48%), Gaps = 17/152 (11%)
Query: 707 WHVGSWGPCSATCGVGIQTRDVYC--------LHPGETPAPPEECRDEKPHALQ-ACNQF 757
W + W PCS CG G Q C +H G A KP A++ ACN
Sbjct: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAAL------SKPKAIRRACNPQ 911
Query: 758 DCP-PGWHIEEWQQCSRTCGG-GTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCA 815
+C P W EW+ CS+TCG G Q R V C Q L D + ++ + C + S ++C+
Sbjct: 912 ECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACS 971
Query: 816 RTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQ 847
R CP G WS+CSV+CG G Q R +C+
Sbjct: 972 RELCPGRWRAGPWSQCSVTCGNGTQERPVLCR 1003
Score = 78.6 bits (192), Expect = 5e-14
Identities = 67/246 (27%), Positives = 96/246 (39%), Gaps = 54/246 (21%)
Query: 1487 WFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLG-RKPCFGHPCV 1545
W WS CS CG G + C+R + ++V CA +P R+ C C
Sbjct: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDH---KMVHRGFCAALSKPKAIRRACNPQECS 914
Query: 1546 Q-------WEPGNRCPGRC--MGRAVR-MQQRHTACQHNSSDSNCDDRKRPTLRRNCTSG 1595
Q WEP ++ GR R+VR +Q H + +C+D RP RR C+
Sbjct: 915 QPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDA-RPESRRACSRE 973
Query: 1596 ACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHC-LGPS 1654
C W GPW C+ CG G Q R V C + Q+++P + R C LGP
Sbjct: 974 LCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGIC-----QEERPETARTCRLGP- 1027
Query: 1655 CDRDCTDTTHYCMFVKHLN--------------------------------LCSLDRYKQ 1682
C R+ +D + V+ L+ CS+ Y +
Sbjct: 1028 CPRNISDPSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYCSIPGYNK 1087
Query: 1683 RCCQSC 1688
CC+SC
Sbjct: 1088 LCCKSC 1093
Score = 78.2 bits (191), Expect = 6e-14
Identities = 61/209 (29%), Positives = 84/209 (40%), Gaps = 32/209 (15%)
Query: 556 LEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLP 615
LEE + E + + WS CS CG G Q + CR L C P
Sbjct: 849 LEEDSVVYE---WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGF----CAALSKP 901
Query: 616 TERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVG-GHQEAIAVC--- 671
+ AC+ S+ + + T +WE PC+ TC G Q C
Sbjct: 902 K---AIRRACNPQECSQPVWV--------TGEWE-----PCSQTCGRTGMQVRSVRCIQP 945
Query: 672 LHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCL 731
LH T ++V+ C+ P +AC+ E CP RW G W CS TCG G Q R V C
Sbjct: 946 LHDNTTRSVHAKHCNDAR--PESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCR 1003
Query: 732 HPGETPAPPEECRDEKPHALQACNQFDCP 760
++ C++E+P + C CP
Sbjct: 1004 TADDSFG---ICQEERPETARTCRLGPCP 1029
Score = 66.6 bits (161), Expect = 2e-10
Identities = 37/129 (28%), Positives = 55/129 (42%), Gaps = 17/129 (13%)
Query: 1423 PQE---PFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEAL----CDHLQKPLAGF 1475
PQE P W G W CS TCG G +++ +C+ + ++ C+ +
Sbjct: 910 PQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESR-- 967
Query: 1476 EPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLG 1535
C+ CP RW WSQCSV+CG G R V C+ + + ++RP
Sbjct: 968 RACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGI--------CQEERPET 1019
Query: 1536 RKPCFGHPC 1544
+ C PC
Sbjct: 1020 ARTCRLGPC 1028
Score = 37.7 bits (86), Expect = 0.095
Identities = 34/113 (30%), Positives = 43/113 (38%), Gaps = 13/113 (11%)
Query: 65 SRNTRSDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCP 124
SR S E G W A G WS CS TCG G C T + G + P
Sbjct: 966 SRRACSRELCPGRWRA-GPWSQCSVTCGNGTQERPVLCRTADDSFG-------ICQEERP 1017
Query: 125 PDAEDFRAQQCSA-YNDVQYQGHYYEWLPRYNDPAAP---CALKCHAQGQNLV 173
A R C +D + + +WL R DP +P + K H QG +
Sbjct: 1018 ETARTCRLGPCPRNISDPSKKSYVVQWLSR-PDPDSPIRKISSKGHCQGDKSI 1069
Score = 35.8 bits (81), Expect = 0.36
Identities = 21/65 (32%), Positives = 29/65 (44%), Gaps = 5/65 (7%)
Query: 710 GSWGP---CSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIE 766
G+W P CS TCG G++ R C +P PA + Q C++ DCP
Sbjct: 565 GAWSPFGSCSRTCGTGVKFRTRQCDNP--HPANGGRTCSGLAYDFQLCSRQDCPDSLADF 622
Query: 767 EWQQC 771
+QC
Sbjct: 623 REEQC 627
Score = 32.0 bits (71), Expect = 5.2
Identities = 32/121 (26%), Positives = 41/121 (33%), Gaps = 35/121 (28%)
Query: 726 RDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIEE------------------ 767
+ ++C HP P C+ +K L C PG H +
Sbjct: 513 KQLWCSHPDN----PYFCKTKKGPPLDGTM---CAPGKHCFKGHCIWLTPDILKRDGSWG 565
Query: 768 -WQ---QCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHL 823
W CSRTCG G + R C D C G A + C+R DCP L
Sbjct: 566 AWSPFGSCSRTCGTGVKFRTRQC-----DNPHPANGGRTCSG-LAYDFQLCSRQDCPDSL 619
Query: 824 A 824
A
Sbjct: 620 A 620
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 177 bits (449), Expect = 8e-44
Identities = 110/342 (32%), Positives = 162/342 (47%), Gaps = 54/342 (15%)
Query: 75 DGNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPPDAE 128
DG W WG W +CSRTCGGG +S R C GR C G+ +Y++C +CPPD +
Sbjct: 526 DGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGK 585
Query: 129 DFRAQQCSAYNDVQY---QGHYYEWLPRYN--DPAAPCALKCHAQGQNLVVELAPKVLDG 183
FR QQC YN Y G+ +W+P+Y P C L C A+G++ KV+DG
Sbjct: 586 SFREQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDG 645
Query: 184 TRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKR 243
T C ++L +C+ G C GCD + S K D CGVC G G++CR V G ++P
Sbjct: 646 TLCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGS----LTPTNY 701
Query: 244 EEN-VIAVPLGSRSVRITVKGPAHLFIESK----TLQGSKGEHSFNS-------PGVFLV 291
N ++ +P G + I VK +H +++ L+ + G++ N LV
Sbjct: 702 GYNDIVTIPAG--ATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILV 759
Query: 292 ENTTVEFQRG----SERQTFK-IPGPLMADFIF--------KTRYTAAKDSVVQFF---- 334
+ T +++ Q+F+ +P PL + K +YT + V F
Sbjct: 760 KGTILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVPNDVDFSMQSS 819
Query: 335 -------FYQPISH-QWRQTDFFPCTVTCGGGYQLNSAECVD 368
QP+ H QW D+ C+ TCG G+Q + EC D
Sbjct: 820 KERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRD 861
Score = 41.6 bits (96), Expect = 0.007
Identities = 39/128 (30%), Positives = 48/128 (37%), Gaps = 26/128 (20%)
Query: 698 CNTEPCPPRWHV--GSWGPCSAT-CGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQAC 754
C+T+ P H GS T CG G + CL P EE KP A
Sbjct: 477 CHTDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCL-------PEEEVERPKPVA---- 525
Query: 755 NQFDCPPGWHI-EEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKS 813
GW W +CSRTCGGG Q C+ C G +A ++S
Sbjct: 526 -----DGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQN-----GGRYCLGRRA-KYQS 574
Query: 814 CARTDCPP 821
C +CPP
Sbjct: 575 CHTEECPP 582
Score = 41.6 bits (96), Expect = 0.007
Identities = 17/48 (35%), Positives = 26/48 (54%)
Query: 481 KWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEEC 528
+W+ +WS+C+ TCG G + R V C + G+ CN LK + C
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPC 882
Score = 40.8 bits (94), Expect = 0.011
Identities = 21/56 (37%), Positives = 27/56 (48%), Gaps = 3/56 (5%)
Query: 706 RWHVGSWGPCSATCGVGIQTRDVYCLHP-GETPAPPEECRDEKPHALQACNQFDCP 760
+W +G W CS+TCG G Q R V C P G+ A + KP + C CP
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKAL--KPEDAKPCESQLCP 888
Score = 40.4 bits (93), Expect = 0.015
Identities = 20/60 (33%), Positives = 28/60 (46%), Gaps = 6/60 (10%)
Query: 1485 ARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPC 1544
A+W WS+CS +CG G+ R V C+ +G +A P+D KPC C
Sbjct: 834 AQWVLGDWSECSSTCGAGWQRRTVECR--DPSGQASATCNKALKPED----AKPCESQLC 887
Score = 39.3 bits (90), Expect = 0.033
Identities = 22/64 (34%), Positives = 28/64 (43%), Gaps = 2/64 (3%)
Query: 710 GSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQ 769
G WG CS TCG G+Q C P E C + Q+C+ +CPP Q
Sbjct: 533 GPWGECSRTCGGGVQFSHRECKDP-EPQNGGRYCLGRRAK-YQSCHTEECPPDGKSFREQ 590
Query: 770 QCSR 773
QC +
Sbjct: 591 QCEK 594
Score = 37.4 bits (85), Expect = 0.12
Identities = 21/57 (36%), Positives = 31/57 (54%), Gaps = 4/57 (7%)
Query: 1428 WEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCP 1484
W G+WS CS+TCG G + + +C +GQ + A C+ KP +PC + CP
Sbjct: 836 WVLGDWSECSSTCG-AGWQRRTVECRDPSGQ--ASATCNKALKP-EDAKPCESQLCP 888
Score = 37.4 bits (85), Expect = 0.12
Identities = 13/25 (52%), Positives = 16/25 (64%)
Query: 763 WHIEEWQQCSRTCGGGTQNRRVTCR 787
W + +W +CS TCG G Q R V CR
Sbjct: 836 WVLGDWSECSSTCGAGWQRRTVECR 860
Score = 37.0 bits (84), Expect = 0.16
Identities = 18/55 (32%), Positives = 24/55 (43%), Gaps = 3/55 (5%)
Query: 1601 WHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSC 1655
W G W C++ CG G+Q R V+C R A C + KP + C C
Sbjct: 836 WVLGDWSECSSTCGAGWQRRTVEC---RDPSGQASATCNKALKPEDAKPCESQLC 887
Score = 35.0 bits (79), Expect = 0.62
Identities = 13/23 (56%), Positives = 17/23 (73%)
Query: 825 VGDWSKCSVSCGVGIQRRKQVCQ 847
+GDWS+CS +CG G QRR C+
Sbjct: 838 LGDWSECSSTCGAGWQRRTVECR 860
Score = 33.5 bits (75), Expect = 1.8
Identities = 13/20 (65%), Positives = 15/20 (75%)
Query: 573 WSACSTTCGPGVQVREVKCR 592
WS CS+TCG G Q R V+CR
Sbjct: 841 WSECSSTCGAGWQRRTVECR 860
Score = 31.2 bits (69), Expect = 8.9
Identities = 11/21 (52%), Positives = 13/21 (61%)
Query: 572 PWSACSTTCGPGVQVREVKCR 592
PW CS TCG GVQ +C+
Sbjct: 534 PWGECSRTCGGGVQFSHRECK 554
>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
Length = 1018
Score = 176 bits (447), Expect = 1e-43
Identities = 118/427 (27%), Positives = 182/427 (42%), Gaps = 82/427 (19%)
Query: 341 HQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDP 400
H W+Q C+ TCG G Q CV P+ YC ++KP P+ + C++ P
Sbjct: 619 HNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYC---DSSMKPTPEEEPCNIFP 675
Query: 401 CPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEW 460
CP+ W+ W+ CS +CG G+Q R +C + L V+ +
Sbjct: 676 CPAF-----------------WDIGEWSECSKTCGLGMQHRQVLC-RQVYANRSLTVQPY 717
Query: 461 KCMYAPKPKVMQTCNLFDCPKW-IAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGG--CN 517
+C + KP+ TC L C +W I +W+ C+V CG G R R V C+++ G+ V CN
Sbjct: 718 RCQHLEKPETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECN 777
Query: 518 PQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACS 577
+L+ + E C + PC K W F+ E CS
Sbjct: 778 MKLRPNDIENCDMG-PCAK-----------SW------------------FLTEWSERCS 807
Query: 578 TTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPASRELDIP 637
CG GV+ R V C T + LP E C RP CD P + ++
Sbjct: 808 AECGAGVRTRSVVC-----MTNHVSSLPLEGC-----GNNRPAEATPCDNGPCTGKV--- 854
Query: 638 LPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCL--HIQTQQTVNDSLCDMVHRPPAMS 695
+W ++ C+ C G Q+ +C+ + T + ++ S C + +PP+
Sbjct: 855 ---------EWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPS-Q 904
Query: 696 QACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDE-KPHALQAC 754
Q+C+ +PC +W W CS +C G + R+V CL T + C + KP ++C
Sbjct: 905 QSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLS--NLCDPQLKPEERESC 962
Query: 755 NQFDCPP 761
N DC P
Sbjct: 963 NPQDCVP 969
Score = 161 bits (407), Expect = 6e-39
Identities = 138/475 (29%), Positives = 191/475 (40%), Gaps = 87/475 (18%)
Query: 376 PDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCG 435
PD + + P+N+ P P P DH W+ T CS +CG
Sbjct: 594 PDRFSPHRPDNLVP----------PAPQPPRRSR----DH-----NWKQLGTTECSTTCG 634
Query: 436 GGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQT-CNLFDCPK-WIAMEWSQCTVT 493
G Q F CV S H E E C + KP + CN+F CP W EWS+C+ T
Sbjct: 635 KGSQYPIFRCVHRSTHEE---APESYCDSSMKPTPEEEPCNIFPCPAFWDIGEWSECSKT 691
Query: 494 CGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQA 553
CG G+++R VLC P H++ KP+ S + K+
Sbjct: 692 CGLGMQHRQVLCRQVYANRSLTVQPYRCQHLE----------KPETTSTCQLKI------ 735
Query: 554 QELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPK 613
E +I T+ W++CS CG G + R+VKC + + +EEC
Sbjct: 736 --CSEWQIRTD--------WTSCSVPCGVGQRTRDVKC-----VSNIGDVVDDEECNMKL 780
Query: 614 LPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLH 673
P + +E CD P ++ L E SE C+A C G + VC+
Sbjct: 781 RPND----IENCDMGPCAKSWF--LTEWSER-----------CSAECGAGVRTRSVVCM- 822
Query: 674 IQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPR--WHVGSWGPCSATCGVGIQTRDVYCL 731
T + L + PA + C+ PC + W GSW CS CG G Q R+V C+
Sbjct: 823 --TNHVSSLPLEGCGNNRPAEATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICV 880
Query: 732 HPGETP---APPEECRD-EKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCR 787
P EC EKP + Q+C+ C W EW CS++C GG + R V C
Sbjct: 881 RKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRC- 939
Query: 788 QLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRR 842
L D + NL D K +SC DC P + K +C V +Q R
Sbjct: 940 -LSDDMTLSNLCDPQL---KPEERESCNPQDCVPEVDENCKDK-YYNCNVVVQAR 989
Score = 131 bits (330), Expect = 5e-30
Identities = 106/376 (28%), Positives = 147/376 (39%), Gaps = 68/376 (18%)
Query: 482 WIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGG----CNPQLKLHIKEECVIPIPCYKP 537
W + ++C+ TCG+G +Y + C+ HR H C+ +K +EE PC
Sbjct: 621 WKQLGTTECSTTCGKGSQYPIFRCV-HRSTHEEAPESYCDSSMKPTPEEEPCNIFPC--- 676
Query: 538 KEKSPVEAKLPWLKQAQELEETRIATEEPTF--IPEPWSACSTTCGPGVQVREVKCRVLL 595
P F I E WS CS TCG G+Q R+V CR +
Sbjct: 677 ----------------------------PAFWDIGE-WSECSKTCGLGMQHRQVLCRQV- 706
Query: 596 TFTQTETELPEEECEGPKLP-TERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFT 654
+ + C+ + P T C L+ C E + DW T
Sbjct: 707 -YANRSLTVQPYRCQHLEKPETTSTCQLKICSEW--------------QIRTDW-----T 746
Query: 655 PCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGP 714
C+ C G + C+ V+D C+M RP + C+ PC W + W
Sbjct: 747 SCSVPCGVGQRTRDVKCVS-NIGDVVDDEECNMKLRPNDIEN-CDMGPCAKSWFLTEWSE 804
Query: 715 -CSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPG--WHIEEWQQC 771
CSA CG G++TR V C+ + P E C + +P C+ C W W QC
Sbjct: 805 RCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPAEATPCDNGPCTGKVEWFAGSWSQC 864
Query: 772 SRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQG-PKASSHKSCARTDCPPHLAVGDWSK 830
S CG GTQ R V C + D +F L C K S +SC C +WS
Sbjct: 865 SIECGSGTQQREVICVRKNAD-TFEVLDPSECSFLEKPPSQQSCHLKPCGAKWFSTEWSM 923
Query: 831 CSVSCGVGIQRRKQVC 846
CS SC G + R+ C
Sbjct: 924 CSKSCQGGFRVREVRC 939
Score = 128 bits (321), Expect = 5e-29
Identities = 69/218 (31%), Positives = 108/218 (49%), Gaps = 5/218 (2%)
Query: 90 TCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQCSAYNDVQYQGHYYE 149
T G S+S T +C G +YK C+ + CP + R QC++YN+ + G +YE
Sbjct: 273 THGATQSFSQPARSTAISCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMGRFYE 332
Query: 150 WLPRYNDPA-APCALKCHAQGQNLVVELAPKVLDGTRCNTDSLDMCISGICQAVGCDRQL 208
W P C L C A G V A KV+DGT C+ + +C+SG C+++GCD L
Sbjct: 333 WEPFAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYL 392
Query: 209 GSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKREENVIAVPLGSRSVRITVKGPAHLF 268
GS+ D CGVC GD + C++V G K H V+ +P G+ + IT ++ +
Sbjct: 393 GSDKVVDKCGVCGGDNTGCQVVSGVFK-HALTSLGYHRVVEIPEGATKINITEMYKSNNY 451
Query: 269 IESKTLQGS---KGEHSFNSPGVFLVENTTVEFQRGSE 303
+ ++ G G + + PG + T ++R +E
Sbjct: 452 LALRSRSGRSIINGNWAIDRPGKYEGGGTMFTYKRPNE 489
Score = 128 bits (321), Expect = 5e-29
Identities = 91/314 (28%), Positives = 130/314 (41%), Gaps = 39/314 (12%)
Query: 576 CSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPT--ERPCLLEACDESPASRE 633
CSTTCG G Q +C T E PE C+ PT E PC + C PA
Sbjct: 629 CSTTCGKGSQYPIFRC----VHRSTHEEAPESYCDSSMKPTPEEEPCNIFPC---PAF-- 679
Query: 634 LDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQ--TVNDSLCDMVHRP 691
W+ ++ C+ TC G Q +C + + TV C + +P
Sbjct: 680 --------------WDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKP 725
Query: 692 PAMSQACNTEPCPPRWHVGS-WGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDE-KPH 749
S C + C W + + W CS CGVG +TRDV C+ EEC + +P+
Sbjct: 726 ETTS-TCQLKICS-EWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPN 783
Query: 750 ALQACNQFDCPPGWHIEEW-QQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKA 808
++ C+ C W + EW ++CS CG G + R V C +L E C +
Sbjct: 784 DIENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMT----NHVSSLPLEGCGNNRP 839
Query: 809 SSHKSCARTDCPPHLA--VGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDL 866
+ C C + G WS+CS+ CG G Q+R+ +C R A + L C L
Sbjct: 840 AEATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEV-LDPSECSFL 898
Query: 867 PGLPLVRSCQMPEC 880
P +SC + C
Sbjct: 899 EKPPSQQSCHLKPC 912
Score = 123 bits (308), Expect = 2e-27
Identities = 70/217 (32%), Positives = 96/217 (44%), Gaps = 12/217 (5%)
Query: 637 PLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQ 696
P P ++W+ G T C+ TC G Q I C+H T + +S CD +P +
Sbjct: 610 PQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEE 669
Query: 697 ACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLH---PGETPAPPEECRD-EKPHALQ 752
CN PCP W +G W CS TCG+G+Q R V C P C+ EKP
Sbjct: 670 PCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTS 729
Query: 753 ACNQFDCPPGWHIE-EWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGP-KASS 810
C C W I +W CS CG G + R V C + D + DE C + +
Sbjct: 730 TCQLKICSE-WQIRTDWTSCSVPCGVGQRTRDVKCVSNIGD----VVDDEECNMKLRPND 784
Query: 811 HKSCARTDCPPHLAVGDWS-KCSVSCGVGIQRRKQVC 846
++C C + +WS +CS CG G++ R VC
Sbjct: 785 IENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVC 821
Score = 119 bits (297), Expect = 3e-26
Identities = 77/275 (28%), Positives = 119/275 (43%), Gaps = 32/275 (11%)
Query: 1432 NWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARWFTSV 1491
+W+ CS CG +G R + +CV G V + C+ +P E C++ C WF +
Sbjct: 744 DWTSCSVPCG-VGQRTRDVKCVSNIGDVVDDEECNMKLRP-NDIENCDMGPCAKSWFLTE 801
Query: 1492 WSQ-CSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPC---VQW 1547
WS+ CS CG G +R V C + P +RP PC PC V+W
Sbjct: 802 WSERCSAECGAGVRTRSVVCMTNHVSSL-----PLEGCGNNRPAEATPCDNGPCTGKVEW 856
Query: 1548 EPGN--RCPGRCMGRAVRMQQRHTACQHNSSD-------SNCDDRKRPTLRRNCTSGACD 1598
G+ +C C QQR C ++D S C ++P +++C C
Sbjct: 857 FAGSWSQCSIECGSGT---QQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCG 913
Query: 1599 VCWHTGPWKPCTAACGRGFQSRKVDCIH-----TRSCKPVAKRHCVQKKKPISWRHCLGP 1653
W + W C+ +C GF+ R+V C+ + C P K ++++ + + C+ P
Sbjct: 914 AKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLK---PEERESCNPQDCV-P 969
Query: 1654 SCDRDCTDTTHYCMFVKHLNLCSLDRYKQRCCQSC 1688
D +C D + C V LC + YK CC SC
Sbjct: 970 EVDENCKDKYYNCNVVVQARLCVYNYYKTACCASC 1004
Score = 114 bits (285), Expect = 8e-25
Identities = 69/217 (31%), Positives = 99/217 (45%), Gaps = 10/217 (4%)
Query: 1417 PTGEPP--PQEPFWEPGNWSHCSATCGHLGARIQRPQCV-MANGQEVSEALCDHLQKPLA 1473
P +PP ++ W+ + CS TCG G++ +CV + +E E+ CD KP
Sbjct: 608 PAPQPPRRSRDHNWKQLGTTECSTTCGK-GSQYPIFRCVHRSTHEEAPESYCDSSMKPTP 666
Query: 1474 GFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRP 1533
EPCNI CPA W WS+CS +CG G RQV C++ AN ++ V P C ++P
Sbjct: 667 EEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSL-TVQPYRCQHLEKP 725
Query: 1534 LGRKPCFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTACQHN----SSDSNCDDRKRPTLR 1589
C C +W+ + V + R C N D C+ + RP
Sbjct: 726 ETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDI 785
Query: 1590 RNCTSGACDVCWHTGPW-KPCTAACGRGFQSRKVDCI 1625
NC G C W W + C+A CG G ++R V C+
Sbjct: 786 ENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCM 822
Score = 72.0 bits (175), Expect = 5e-12
Identities = 46/156 (29%), Positives = 72/156 (46%), Gaps = 14/156 (8%)
Query: 1428 WEPGNWSHCSATCGHLGARIQRPQCVMANG---QEVSEALCDHLQKPLAGFEPCNIRDCP 1484
W G+WS CS CG G + + CV N + + + C L+KP + + C+++ C
Sbjct: 856 WFAGSWSQCSIECGS-GTQQREVICVRKNADTFEVLDPSECSFLEKPPSQ-QSCHLKPCG 913
Query: 1485 ARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPC 1544
A+WF++ WS CS SC G+ R+V C + + C P+ +P R+ C C
Sbjct: 914 AKWFSTEWSMCSKSCQGGFRVREVRCL------SDDMTLSNLCDPQLKPEERESCNPQDC 967
Query: 1545 VQWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNC 1580
V E C + V +Q R C +N + C
Sbjct: 968 VP-EVDENCKDKYYNCNVVVQAR--LCVYNYYKTAC 1000
Score = 58.5 bits (140), Expect = 5e-08
Identities = 38/146 (26%), Positives = 59/146 (40%), Gaps = 17/146 (11%)
Query: 737 PAPPEECRDEKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFL 796
P PP RD W +CS TCG G+Q C T
Sbjct: 610 PQPPRRSRDHN---------------WKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAP 654
Query: 797 NLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRI 856
+ P + C CP +G+WS+CS +CG+G+Q R+ +C+++ A R +
Sbjct: 655 ESYCDSSMKP-TPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYA-NRSL 712
Query: 857 PLSEMMCRDLPGLPLVRSCQMPECSK 882
+ C+ L +CQ+ CS+
Sbjct: 713 TVQPYRCQHLEKPETTSTCQLKICSE 738
Score = 42.4 bits (98), Expect = 0.004
Identities = 16/28 (57%), Positives = 17/28 (60%)
Query: 76 GNWDAWGDWSDCSRTCGGGASYSLRRCL 103
G W AWG WS CSR+C GG R CL
Sbjct: 54 GVWGAWGPWSACSRSCSGGVMEQTRPCL 81
Score = 40.0 bits (92), Expect = 0.019
Identities = 62/298 (20%), Positives = 106/298 (35%), Gaps = 45/298 (15%)
Query: 78 WDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQCSA 137
WD G+WS+CS+TCG G + C ++ C + + P + + CS
Sbjct: 680 WDI-GEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICS- 737
Query: 138 YNDVQYQGHYYEWLPR--YNDPAAPCALKCHAQGQNLVVELAPKVLDGTRCNTDSLDMCI 195
EW R + + PC + + V + V+D CN I
Sbjct: 738 -----------EWQIRTDWTSCSVPCGVGQRTRDVKCVSNIG-DVVDDEECNMKLRPNDI 785
Query: 196 SGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKREENVIAVPL--- 252
C C + + C G G R V + +HVS ++PL
Sbjct: 786 EN-CDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMT-NHVS---------SLPLEGC 834
Query: 253 -GSRSVRITV--KGPAHLFIESKTLQGSKGEHSFNSPGVFLVENTTVEFQRGSERQTFKI 309
+R T GP +E GS + S G + + ++ ++ TF++
Sbjct: 835 GNNRPAEATPCDNGPCTGKVE--WFAGSWSQCSIEC-GSGTQQREVICVRKNAD--TFEV 889
Query: 310 PGPLMADFIFKTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQLNSAECV 367
P F+ K Q +P +W T++ C+ +C GG+++ C+
Sbjct: 890 LDPSECSFL-------EKPPSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCL 940
Score = 34.3 bits (77), Expect = 1.1
Identities = 22/69 (31%), Positives = 32/69 (46%), Gaps = 4/69 (5%)
Query: 74 KDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCP-PDAEDFRA 132
+D NW G ++CS TCG G+ Y + RC+ E Y C + P P+ E
Sbjct: 617 RDHNWKQLGT-TECSTTCGKGSQYPIFRCVHRSTHEEAPESY--CDSSMKPTPEEEPCNI 673
Query: 133 QQCSAYNDV 141
C A+ D+
Sbjct: 674 FPCPAFWDI 682
Score = 32.0 bits (71), Expect = 5.2
Identities = 11/24 (45%), Positives = 16/24 (66%)
Query: 426 PWTACSVSCGGGIQRRSFVCVEES 449
PW+ACS SC GG+ ++ C+ S
Sbjct: 61 PWSACSRSCSGGVMEQTRPCLPRS 84
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 162 bits (410), Expect = 3e-39
Identities = 117/427 (27%), Positives = 173/427 (40%), Gaps = 87/427 (20%)
Query: 76 GNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPPDAED 129
GNW +WG W CSR+CGGG ++ R C GR C G+ Y++CS CPP+ +
Sbjct: 568 GNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKS 627
Query: 130 FRAQQCSAYNDVQYQGH----YYEWLPRYND--PAAPCALKCHAQGQNLVVELAPKVLDG 183
FR +QC A N Q + EW+P+Y PA C L C A+G V +PKV DG
Sbjct: 628 FRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDG 687
Query: 184 TRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKR 243
T C S +C+ G C GCD +GS + D CGVC GD S+C + G + K
Sbjct: 688 TECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVG---TFNKKSKG 744
Query: 244 EENVIAVPLGSRSVRI---TVKGPAHLFIESKTLQGSKGEHSFN-------SPGVFLVEN 293
+V+ +P G+ +++ K F L+ GE+ N S + +
Sbjct: 745 YTDVVRIPEGATHIKVRQFKAKDQTR-FTAYLALKKKNGEYLINGKYMISTSETIIDING 803
Query: 294 TTVEFQRGSERQTFKIPGPLMADFIFKTRYTAAKD-SVVQFFFYQPISHQWRQTDFFPCT 352
T + + S R DF+ Y+A K+ +VQ P
Sbjct: 804 TVMNYSGWSHRD----------DFLHGMGYSATKEILIVQILATDP-------------- 839
Query: 353 VTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMP 412
+ +D+R VP K PK+ +S G ++
Sbjct: 840 -----------TKPLDVRYSFFVPK----------KSTPKVNSV------TSHGSNKVGS 872
Query: 413 YDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQ 472
+ P+W PW ACS +C G R+ C + + + C + +P +
Sbjct: 873 H---TSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGN------RKLAKGCPLSQRPSAFK 923
Query: 473 TCNLFDC 479
C L C
Sbjct: 924 QCLLKKC 930
Score = 40.0 bits (92), Expect = 0.019
Identities = 23/69 (33%), Positives = 30/69 (43%), Gaps = 6/69 (8%)
Query: 710 GSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECR--DEKPHALQACNQFDCPPGWHIEE 767
GSWG CS +CG G+Q +C PAP R K ++C+ CPP
Sbjct: 574 GSWGQCSRSCGGGVQFAYRHC----NNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFR 629
Query: 768 WQQCSRTCG 776
+QC G
Sbjct: 630 HEQCEAKNG 638
Score = 38.1 bits (87), Expect = 0.073
Identities = 16/55 (29%), Positives = 26/55 (47%), Gaps = 3/55 (5%)
Query: 1601 WHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSC 1655
W TGPW C+ C G+ +R V C + + C ++P +++ CL C
Sbjct: 879 WVTGPWLACSRTCDTGWHTRTVQC---QDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
Score = 36.2 bits (82), Expect = 0.28
Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 6/55 (10%)
Query: 768 WQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPH 822
W QCSR+CGGG Q C + C G K + ++SC+ CPP+
Sbjct: 576 WGQCSRSCGGGVQFAYRHCNNPAPRN-----NGRYCTG-KRAIYRSCSLMPCPPN 624
Score = 36.2 bits (82), Expect = 0.28
Identities = 18/59 (30%), Positives = 27/59 (45%), Gaps = 6/59 (10%)
Query: 1486 RWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPC 1544
+W T W CS +C G+H+R V C+ +G ++ + C RP K C C
Sbjct: 878 QWVTGPWLACSRTCDTGWHTRTVQCQ----DGNRKLA--KGCPLSQRPSAFKQCLLKKC 930
Score = 35.4 bits (80), Expect = 0.47
Identities = 13/30 (43%), Positives = 18/30 (60%)
Query: 563 TEEPTFIPEPWSACSTTCGPGVQVREVKCR 592
T +P ++ PW ACS TC G R V+C+
Sbjct: 874 TSQPQWVTGPWLACSRTCDTGWHTRTVQCQ 903
Score = 33.9 bits (76), Expect = 1.4
Identities = 13/26 (50%), Positives = 14/26 (53%)
Query: 705 PRWHVGSWGPCSATCGVGIQTRDVYC 730
P+W G W CS TC G TR V C
Sbjct: 877 PQWVTGPWLACSRTCDTGWHTRTVQC 902
Score = 31.6 bits (70), Expect = 6.8
Identities = 13/51 (25%), Positives = 23/51 (45%)
Query: 480 PKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVI 530
P+W+ W C+ TC G R V C + + GC + ++C++
Sbjct: 877 PQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLL 927
Score = 31.2 bits (69), Expect = 8.9
Identities = 19/59 (32%), Positives = 24/59 (40%), Gaps = 5/59 (8%)
Query: 761 PGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDC 819
P W W CSRTC G R V C+ DG+ L+ + S+ K C C
Sbjct: 877 PQWVTGPWLACSRTCDTGWHTRTVQCQ----DGN-RKLAKGCPLSQRPSAFKQCLLKKC 930
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 155 bits (393), Expect = 2e-37
Identities = 86/219 (39%), Positives = 113/219 (51%), Gaps = 21/219 (9%)
Query: 76 GNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPP-DAE 128
G W WG W DCSRTCGGG +S R C G+ CEG+ R+++C+ DCP A
Sbjct: 521 GGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSAL 580
Query: 129 DFRAQQCSAYND-----VQYQGHYYEWLPRYND--PAAPCALKCHAQGQNLVVELAPKVL 181
FR +QC+AYN + G +W+PRY P C L C AQ L P+V+
Sbjct: 581 TFREEQCAAYNHRTDLFKSFPGPM-DWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVV 639
Query: 182 DGTRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPE 241
DGT C+ DS +C+ G C GCDR +GS K D C VC GDGS C QS S
Sbjct: 640 DGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGC---SKQSGSFRKFR 696
Query: 242 KREENVIAVPLGSRSVRITVKG-PAH--LFIESKTLQGS 277
NV+ +P G+ + + +G P H +++ K GS
Sbjct: 697 YGYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGS 735
Score = 43.5 bits (101), Expect = 0.002
Identities = 37/122 (30%), Positives = 45/122 (36%), Gaps = 24/122 (19%)
Query: 655 PCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPC----------- 703
PC A GH A+C QT + D PA QAC C
Sbjct: 466 PCAALWCSGHLNGHAMC------QTKHSPWADGTPCGPA--QACMGGRCLHMDQLQDFNI 517
Query: 704 PPRWHVGSWGP---CSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCP 760
P G WGP CS TCG G+Q C P P + + + ++CN DCP
Sbjct: 518 PQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRP--VPRNGGKYCEGRRTRFRSCNTEDCP 575
Query: 761 PG 762
G
Sbjct: 576 TG 577
Score = 37.4 bits (85), Expect = 0.12
Identities = 36/144 (25%), Positives = 52/144 (36%), Gaps = 19/144 (13%)
Query: 682 DSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPA-PP 740
D C + P + PC W CS + + TP P
Sbjct: 446 DRQCQLTFGPDSRHCPQLPPPCAALW-------CSGHLNGHAMCQTKHSPWADGTPCGPA 498
Query: 741 EECRDEKPHALQACNQFDCPP--GWHI-EEWQQCSRTCGGGTQ-NRRVTCRQLLTDGSFL 796
+ C + + F+ P GW W CSRTCGGG Q + R R + +G
Sbjct: 499 QACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGG-- 556
Query: 797 NLSDELCQGPKASSHKSCARTDCP 820
+ C+G + + +SC DCP
Sbjct: 557 ----KYCEG-RRTRFRSCNTEDCP 575
Score = 32.7 bits (73), Expect = 3.1
Identities = 23/66 (34%), Positives = 25/66 (37%), Gaps = 12/66 (18%)
Query: 1423 PQEPFWEP-GNWSHCSATCGHLGARIQRPQC---VMANGQEVSEALCDHLQKPLAGFEPC 1478
PQ W P G W CS TCG G + C V NG + E F C
Sbjct: 518 PQAGGWGPWGPWGDCSRTCGG-GVQFSSRDCTRPVPRNGGKYCEG-------RRTRFRSC 569
Query: 1479 NIRDCP 1484
N DCP
Sbjct: 570 NTEDCP 575
Score = 31.6 bits (70), Expect = 6.8
Identities = 18/64 (28%), Positives = 27/64 (42%), Gaps = 7/64 (10%)
Query: 426 PWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPKWIAM 485
PW CS +CGGG+Q S C E + + ++CN DCP A+
Sbjct: 528 PWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRF-------RSCNTEDCPTGSAL 580
Query: 486 EWSQ 489
+ +
Sbjct: 581 TFRE 584
Score = 31.2 bits (69), Expect = 8.9
Identities = 30/103 (29%), Positives = 36/103 (34%), Gaps = 21/103 (20%)
Query: 572 PWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEAC------ 625
PW CS TCG GVQ C T+ + CEG + R C E C
Sbjct: 528 PWGDCSRTCGGGVQFSSRDC------TRPVPRNGGKYCEG-RRTRFRSCNTEDCPTGSAL 580
Query: 626 ---DESPASRELDIPLPEDSETTYDW--EYAGFTP---CTATC 660
+E A+ L + DW Y G P C TC
Sbjct: 581 TFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTC 623
Score = 31.2 bits (69), Expect = 8.9
Identities = 19/72 (26%), Positives = 32/72 (44%), Gaps = 18/72 (25%)
Query: 351 CTVTCGGGYQLNSAECVDIRLKRVVPDH---YCHYYPENVKPKPKLKECSMDPCPSSDGF 407
C+ TCGGG Q +S +C R VP + YC + + + C+ + CP+
Sbjct: 532 CSRTCGGGVQFSSRDCT-----RPVPRNGGKYCE------GRRTRFRSCNTEDCPTGSAL 580
Query: 408 ----KEIMPYDH 415
++ Y+H
Sbjct: 581 TFREEQCAAYNH 592
>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
sapiens]
Length = 1074
Score = 151 bits (382), Expect = 5e-36
Identities = 119/428 (27%), Positives = 165/428 (38%), Gaps = 81/428 (18%)
Query: 343 WRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCP 402
W++ C+ +CG G C+ + + C +P + C PCP
Sbjct: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSC---AAGARPPASPEPCHGTPCP 724
Query: 403 SSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKC 462
P WE WT+CS SCG G Q R C +E G V +C
Sbjct: 725 -----------------PYWEAGEWTSCSRSCGPGTQHRQLQCRQE-FGGGGSSVPPERC 766
Query: 463 MYAPKPKVMQTCNLFDCPKW-IAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLK 521
+ P+P + Q+C L C W + WSQC+V CGRG R R V C+ + G+ V
Sbjct: 767 GHLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVS------- 819
Query: 522 LHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSA-CSTTC 580
++EC P Q E + + WS+ CS C
Sbjct: 820 ---EQECASGPP------------------QPPSREACDMGPCTTAWFHSDWSSKCSAEC 858
Query: 581 GPGVQVREVKC---RVLLTFTQTETELPEEECEGPKLPT-ERPCLLEACDESPASRELDI 636
G G+Q R V C L Q E G PT RP + AC P R
Sbjct: 859 GTGIQRRSVVCLGSGAALGPGQGEAGAG----TGQSCPTGSRPPDMRACSLGPCER---- 910
Query: 637 PLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCL-HIQTQQTV-NDSLCDMVHRPPAM 694
T+ W + C++ C G Q +C+ + T+ V + S C + RPPA+
Sbjct: 911 --------TWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPAL 962
Query: 695 SQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGE---TPAPPEECRDEKPHAL 751
Q C + C RW W PCS +C G QTR+V CL + T PP+ +P
Sbjct: 963 -QPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQ----LRPSRK 1017
Query: 752 QACNQFDC 759
+ CN C
Sbjct: 1018 RPCNSQPC 1025
Score = 150 bits (380), Expect = 8e-36
Identities = 119/387 (30%), Positives = 156/387 (40%), Gaps = 71/387 (18%)
Query: 418 PLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVM-QTCNL 476
P W+ +ACS SCG G+ R F+C+ E+ +E C +P + C+
Sbjct: 664 PAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEEL---DERSCAAGARPPASPEPCHG 720
Query: 477 FDCPK-WIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCY 535
CP W A EW+ C+ +CG G ++R + C R E GG + V P C
Sbjct: 721 TPCPPYWEAGEWTSCSRSCGPGTQHRQLQC---RQEFGGGGSS----------VPPERC- 766
Query: 536 KPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLL 595
LP Q + E + PWS CS CG G + R+V+C
Sbjct: 767 ---------GHLPRPNITQSCQLRLCGHWE---VGSPWSQCSVRCGRGQRSRQVRC---- 810
Query: 596 TFTQTETELPEEEC-EGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFT 654
E+ E+EC GP P R EACD P T W ++ ++
Sbjct: 811 -VGNNGDEVSEQECASGPPQPPSR----EACDMGPC--------------TTAWFHSDWS 851
Query: 655 P-CTATCVGGHQEAIAVCLHIQTQQTVNDS--------LCDMVHRPPAMSQACNTEPCPP 705
C+A C G Q VCL C RPP M +AC+ PC
Sbjct: 852 SKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDM-RACSLGPCER 910
Query: 706 --RWHVGSWGPCSATCGVGIQTRDVYCLHPGETP---APPEECRD-EKPHALQACNQFDC 759
RW+ G WG CS+ CG G Q RD+ C+ T P C +P ALQ C C
Sbjct: 911 TWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQAC 970
Query: 760 PPGWHIEEWQQCSRTCGGGTQNRRVTC 786
W W CSR+C GGTQ R V C
Sbjct: 971 QDRWFSTPWSPCSRSCQGGTQTREVQC 997
Score = 137 bits (345), Expect = 9e-32
Identities = 89/284 (31%), Positives = 117/284 (41%), Gaps = 30/284 (10%)
Query: 1428 WEPGN-WSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPAR 1486
WE G+ WS CS CG G R ++ +CV NG EVSE C E C++ C
Sbjct: 786 WEVGSPWSQCSVRCGR-GQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTA 844
Query: 1487 WFTSVWS-QCSVSCGEGYHSRQVTCKRTKA-----NGTVQVVSPRACAPKDRPLGRKPCF 1540
WF S WS +CS CG G R V C + A G + ++C RP + C
Sbjct: 845 WFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACS 904
Query: 1541 GHPCVQ-WE----PGNRCPGRCMGRAVRMQQRHTACQHN-------SSDSNCDDRKRPTL 1588
PC + W P C C Q+R C +S SNC RP
Sbjct: 905 LGPCERTWRWYTGPWGECSSECGSGT---QRRDIICVSKLGTEFNVTSPSNCSHLPRPPA 961
Query: 1589 RRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWR 1648
+ C AC W + PW PC+ +C G Q+R+V C+ T C + +P R
Sbjct: 962 LQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQ---TLSTRCPPQLRPSRKR 1018
Query: 1649 HCLGPSC----DRDCTDTTHYCMFVKHLNLCSLDRYKQRCCQSC 1688
C C D C D++ +C V LC Y CC+SC
Sbjct: 1019 PCNSQPCSQRPDDQCKDSSPHCPLVVQARLCVYPYYTATCCRSC 1062
Score = 129 bits (324), Expect = 2e-29
Identities = 88/293 (30%), Positives = 128/293 (43%), Gaps = 28/293 (9%)
Query: 610 EGPKLPTERPCLLEACDESPASRELDIP---------LPEDSETTYDWEYAGFTPCTATC 660
E P P RP A R++ IP P S Y W+ G + C+A+C
Sbjct: 626 EPPLAPAPRP----ARTPGTLQRQVRIPQMPAPPHPRTPLGSPAAY-WKRVGHSACSASC 680
Query: 661 VGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCG 720
G I +C+ ++ + +++ C RPPA + C+ PCPP W G W CS +CG
Sbjct: 681 GKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCG 740
Query: 721 VGIQTRDVYCLHP---GETPAPPEECRD-EKPHALQACNQFDCPPGWHI-EEWQQCSRTC 775
G Q R + C G + PPE C +P+ Q+C C W + W QCS C
Sbjct: 741 PGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC-GHWEVGSPWSQCSVRC 799
Query: 776 GGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDW-SKCSVS 834
G G ++R+V C + +G ++ + P+ S ++C C DW SKCS
Sbjct: 800 GRGQRSRQVRC--VGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWSSKCSAE 857
Query: 835 CGVGIQRRKQVCQRLAA-----KGRRIPLSEMMCRDLPGLPLVRSCQMPECSK 882
CG GIQRR VC A +G + C P +R+C + C +
Sbjct: 858 CGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCER 910
Score = 122 bits (306), Expect = 3e-27
Identities = 64/197 (32%), Positives = 97/197 (49%), Gaps = 5/197 (2%)
Query: 108 CEGQNIRYKTCSNHDCPPDAEDFRAQQCSAYNDVQYQGHYYEWLPRYNDPAAP-CALKCH 166
C G++ + + CS CPP+ D RA QC+A+N ++ G Y+W P + C L C
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
Query: 167 AQGQNLVVELAPKVLDGTRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGST 226
+G V KV DGT C + D+C++G C + GCD LGS + D CGVC GD ST
Sbjct: 424 PRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDST 483
Query: 227 CRLVRGQSKSHVSPEKREENVIAVPLGSRSVRITVKGPAHLFIESKTLQGS---KGEHSF 283
CRLV G P + ++ +P G+ ++I P+ ++ + G G +
Sbjct: 484 CRLVSGNLTDRGGP-LGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAV 542
Query: 284 NSPGVFLVENTTVEFQR 300
+ PG + T + R
Sbjct: 543 DPPGSYRAGGTVFRYNR 559
Score = 112 bits (280), Expect = 3e-24
Identities = 97/387 (25%), Positives = 139/387 (35%), Gaps = 79/387 (20%)
Query: 482 WIAMEWSQCTVTCGRGLRYRVVLCINHR-GEHV------GGCNPQLKLHIKEECVIPIPC 534
W + S C+ +CG+G+ + LCI+ GE + G P P PC
Sbjct: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPAS---------PEPC 718
Query: 535 YKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVL 594
+ P +A E W++CS +CGPG Q R+++CR
Sbjct: 719 HG--------TPCPPYWEAGE-----------------WTSCSRSCGPGTQHRQLQCR-- 751
Query: 595 LTFTQTETELPEEEC-EGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAG- 652
F + +P E C P+ + C L C WE
Sbjct: 752 QEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGH--------------------WEVGSP 791
Query: 653 FTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSW 712
++ C+ C G + C+ V++ C P +AC+ PC W W
Sbjct: 792 WSQCSVRCGRGQRSRQVRCVG-NNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDW 850
Query: 713 -GPCSATCGVGIQTRDVYCLHPGETPAP---------PEEC-RDEKPHALQACNQFDCPP 761
CSA CG GIQ R V CL G P + C +P ++AC+ C
Sbjct: 851 SSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCER 910
Query: 762 --GWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDC 819
W+ W +CS CG GTQ R + C L + P+ + + C C
Sbjct: 911 TWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQAC 970
Query: 820 PPHLAVGDWSKCSVSCGVGIQRRKQVC 846
WS CS SC G Q R+ C
Sbjct: 971 QDRWFSTPWSPCSRSCQGGTQTREVQC 997
Score = 108 bits (269), Expect = 6e-23
Identities = 85/281 (30%), Positives = 111/281 (39%), Gaps = 44/281 (15%)
Query: 1417 PTGEPPPQEPFWEPGNWSHCSATCGHLGARIQRP--QCVMA-NGQEVSEALCDHLQKPLA 1473
P G P +W+ S CSA+CG + RP C+ +G+E+ E C +P A
Sbjct: 660 PLGSPAA---YWKRVGHSACSASCGK---GVWRPIFLCISRESGEELDERSCAAGARPPA 713
Query: 1474 GFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRP 1533
EPC+ CP W W+ CS SCG G RQ+ C R + G V P C RP
Sbjct: 714 SPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQC-RQEFGGGGSSVPPERCGHLPRP 772
Query: 1534 LGRKPCFGHPCVQWE---PGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDR-----KR 1585
+ C C WE P ++C RC GR R R C N+ D + +
Sbjct: 773 NITQSCQLRLCGHWEVGSPWSQCSVRC-GRGQR--SRQVRCVGNNGDEVSEQECASGPPQ 829
Query: 1586 PTLRRNCTSGACDVCWHTGPW-KPCTAACGRGFQSRKVDCIHT----------------R 1628
P R C G C W W C+A CG G Q R V C+ + +
Sbjct: 830 PPSREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQ 889
Query: 1629 SC----KPVAKRHCVQKKKPISWRHCLGP--SCDRDCTDTT 1663
SC +P R C +WR GP C +C T
Sbjct: 890 SCPTGSRPPDMRACSLGPCERTWRWYTGPWGECSSECGSGT 930
Score = 103 bits (257), Expect = 1e-21
Identities = 92/328 (28%), Positives = 124/328 (37%), Gaps = 52/328 (15%)
Query: 574 SACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPASRE 633
SACS +CG GV + L ++ EL E C P P E C +P
Sbjct: 674 SACSASCGKGVW----RPIFLCISRESGEELDERSCAAGARPPASP---EPCHGTPCPPY 726
Query: 634 LDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHI--QTQQTVNDSLCDMVHRP 691
WE +T C+ +C G Q C +V C + R
Sbjct: 727 --------------WEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPR- 771
Query: 692 PAMSQACNTEPCPPRWHVGS-WGPCSATCGVGIQTRDVYCLHPGETPAPPEECRD--EKP 748
P ++Q+C C W VGS W CS CG G ++R V C+ +EC +P
Sbjct: 772 PNITQSCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQP 830
Query: 749 HALQACNQFDCPPGWHIEEW-QQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPK 807
+ +AC+ C W +W +CS CG G Q R V C L G+ L QG
Sbjct: 831 PSREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVC---LGSGAALGPG----QGEA 883
Query: 808 -ASSHKSCARTDCPPHLA--------------VGDWSKCSVSCGVGIQRRKQVCQRLAAK 852
A + +SC PP + G W +CS CG G QRR +C
Sbjct: 884 GAGTGQSCPTGSRPPDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGT 943
Query: 853 GRRIPLSEMMCRDLPGLPLVRSCQMPEC 880
+ S C LP P ++ CQ C
Sbjct: 944 EFNV-TSPSNCSHLPRPPALQPCQGQAC 970
Score = 96.7 bits (239), Expect = 2e-19
Identities = 99/418 (23%), Positives = 154/418 (36%), Gaps = 89/418 (21%)
Query: 338 PISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLK-----RVVPDHYCHYYPE-NVKPKP 391
P W ++ C+ +CG G Q +C R + VP C + P N+
Sbjct: 722 PCPPYWEAGEWTSCSRSCGPGTQHRQLQC---RQEFGGGGSSVPPERCGHLPRPNITQSC 778
Query: 392 KLKECSMDPCPSSDGFKEIMPYDHFQPLPRWE-HNPWTACSVSCGGGIQRRSFVCVEESM 450
+L+ C WE +PW+ CSV CG G + R CV +
Sbjct: 779 QLRLCG-----------------------HWEVGSPWSQCSVRCGRGQRSRQVRCVGNN- 814
Query: 451 HGEILQVEEWKCMYAP-KPKVMQTCNLFDCPK-WIAMEWS-QCTVTCGRGLRYRVVLCIN 507
G+ +V E +C P +P + C++ C W +WS +C+ CG G++ R V+C+
Sbjct: 815 -GD--EVSEQECASGPPQPPSREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLG 871
Query: 508 HRGEHVGGCNPQLKLHIKEECVIPI--PCYKPKEKSPVEAKLPWLKQAQELEETRIATEE 565
G +G + + C P + P E W
Sbjct: 872 S-GAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCERTWRWYTG------------- 917
Query: 566 PTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEAC 625
PW CS+ CG G Q R++ C V T+ P P+ P +PC +AC
Sbjct: 918 ------PWGECSSECGSGTQRRDIIC-VSKLGTEFNVTSPSNCSHLPRPPALQPCQGQAC 970
Query: 626 DESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLC 685
+ W ++PC+ +C GG Q CL T QT++
Sbjct: 971 QDR-------------------WFSTPWSPCSRSCQGGTQTREVQCL--STNQTLSTRCP 1009
Query: 686 DMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEEC 743
+ P+ + CN++PC R S C + +Q R C++P T C
Sbjct: 1010 PQLR--PSRKRPCNSQPCSQR-PDDQCKDSSPHCPLVVQAR--LCVYPYYTATCCRSC 1062
Score = 43.5 bits (101), Expect = 0.002
Identities = 73/363 (20%), Positives = 122/363 (33%), Gaps = 77/363 (21%)
Query: 78 WDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQCSA 137
W+A G+W+ CSR+CG G + +C G ++ + C + P + + + C
Sbjct: 727 WEA-GEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC-- 783
Query: 138 YNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQ---------NLVVELAPKVLDGTRCNT 188
GH+ P + C+++C +GQ N E++ +
Sbjct: 784 -------GHW-----EVGSPWSQCSVRC-GRGQRSRQVRCVGNNGDEVSEQECASGPPQP 830
Query: 189 DSLDMCISGICQAV--------GCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSP 240
S + C G C C + G+ + + VC G G+ +G++ +
Sbjct: 831 PSREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSV-VCLGSGAALGPGQGEAGAGTGQ 889
Query: 241 EKREENVIAVPLGSR--SVRITVKGPAHLFIESKTLQGSKGEHSFNSPG------VFLVE 292
+ P GSR +R GP T G GE S + V
Sbjct: 890 --------SCPTGSRPPDMRACSLGPCERTWRWYT--GPWGECSSECGSGTQRRDIICVS 939
Query: 293 NTTVEFQRGSERQTFKIPGPLMADFIFKTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCT 352
EF S +P P +Q Q +W T + PC+
Sbjct: 940 KLGTEFNVTSPSNCSHLPRP----------------PALQPCQGQACQDRWFSTPWSPCS 983
Query: 353 VTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPS--SDGFKEI 410
+C GG Q +C+ P ++P K + C+ PC D K+
Sbjct: 984 RSCQGGTQTREVQCLSTN------QTLSTRCPPQLRPSRK-RPCNSQPCSQRPDDQCKDS 1036
Query: 411 MPY 413
P+
Sbjct: 1037 SPH 1039
Score = 35.4 bits (80), Expect = 0.47
Identities = 12/20 (60%), Positives = 15/20 (75%)
Query: 828 WSKCSVSCGVGIQRRKQVCQ 847
W+ CS CGVG+QRR + CQ
Sbjct: 53 WASCSQPCGVGVQRRSRTCQ 72
Score = 34.3 bits (77), Expect = 1.1
Identities = 12/35 (34%), Positives = 16/35 (45%)
Query: 68 TRSDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRC 102
T + +G W W W+ CS+ CG G R C
Sbjct: 37 TEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTC 71
Score = 33.1 bits (74), Expect = 2.3
Identities = 23/54 (42%), Positives = 24/54 (44%), Gaps = 15/54 (27%)
Query: 710 GSWGP------CSATCGVGIQTRDVYC------LHPGETPAPPEECRDEKPHAL 751
G WGP CS CGVG+Q R C LHP P PP R P AL
Sbjct: 45 GVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQLHP-SLPLPPRPPR--HPEAL 95
Score = 32.0 bits (71), Expect = 5.2
Identities = 19/54 (35%), Positives = 24/54 (44%), Gaps = 4/54 (7%)
Query: 76 GNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTC-SNHDCPPDAE 128
G+W+ WS CS CG G RC+ G N G + + C S PP E
Sbjct: 784 GHWEVGSPWSQCSVRCGRGQRSRQVRCV-GNN--GDEVSEQECASGPPQPPSRE 834
>gi|223718260 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 138 bits (347), Expect = 5e-32
Identities = 82/250 (32%), Positives = 117/250 (46%), Gaps = 38/250 (15%)
Query: 78 WDAWGDWSDCSRTCGGGASYSLRRCLT----------GRNCEGQNIRYKTCSNHDCPPDA 127
W W W+ CSR+CGGG + R CL R C G + RY+ C +CPPD
Sbjct: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
Query: 128 EDFRAQQCSAYNDVQYQGHYYEWLPRYND-----PAAPCALKC-HAQGQNLVVELAPKVL 181
FR +QC ++N Y G ++W P Y D + PC L C GQ +L
Sbjct: 110 RSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQR---QLMVPAR 166
Query: 182 DGTRCN-TDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSP 240
DGT C TD +C+SG C+ +GCD L S D CG+C GDGS+C +HV+
Sbjct: 167 DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSC--------THVTG 218
Query: 241 EKREEN-------VIAVPLGSRSVRITVKGPAHLFIESKTLQG---SKGEHSFNSPGVFL 290
R+ N V +P G+R ++I + + + G G + +SP F
Sbjct: 219 NYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFN 278
Query: 291 VENTTVEFQR 300
+ T V+++R
Sbjct: 279 IAGTVVKYRR 288
Score = 138 bits (347), Expect = 5e-32
Identities = 100/374 (26%), Positives = 148/374 (39%), Gaps = 62/374 (16%)
Query: 478 DCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKP 537
D +W C+ TC G+ +C+ + G V
Sbjct: 564 DMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEV------------------------ 599
Query: 538 KEKSPVEAKLPWLKQAQELEETRIATE-EPTFIPEPWSACSTTCGPGVQVREVKCRVLLT 596
+ S +A L + + + E E +P + WS CS TCG G Q R V+C +L+
Sbjct: 600 -DDSYCDA----LTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLS 654
Query: 597 FTQTETELPEEECEGPKL--PTERP-CLLEACDESPASRELDIPLPEDSETTYDWEYAGF 653
++ + + CE + P ER C AC WE + +
Sbjct: 655 -PGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQ-------------------WEMSEW 694
Query: 654 TPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWG 713
+ CTA C E V I+ + ++ LCD RP + C PC +W V WG
Sbjct: 695 SECTAKC----GERSVVTRDIRCSE--DEKLCDPNTRPVG-EKNCTGPPCDRQWTVSDWG 747
Query: 714 PCSATCGVGIQTRDVYCLHPGETPAPPEECRDE-KPHALQACNQFDCPPGWHIEEWQQCS 772
PCS +CG G R VYC P +C+ E KP A+ C +CP W ++W++C+
Sbjct: 748 PCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCN 807
Query: 773 RTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCS 832
TCG G + R V C +L E K +C C WS+C+
Sbjct: 808 TTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWY-TSPWSECT 866
Query: 833 VSCGVGIQRRKQVC 846
+CGVG++ R C
Sbjct: 867 KTCGVGVRMRDVKC 880
Score = 130 bits (326), Expect = 1e-29
Identities = 83/242 (34%), Positives = 109/242 (45%), Gaps = 11/242 (4%)
Query: 1419 GEPPPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPC 1478
G P W+ + CSATC G CV +G EV ++ CD L +P E C
Sbjct: 559 GVSPADMYRWKLSSHEPCSATCT-TGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFC 617
Query: 1479 NIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRAC--APKDRPLGR 1536
R+C RW TS WS+CS +CGEGY R V C + + G V C A RP R
Sbjct: 618 AGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEER 677
Query: 1537 KPCFGHPC-VQWEPG--NRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCT 1593
K C C QWE + C +C R+V R C + + CD RP +NCT
Sbjct: 678 KTCRNPACGPQWEMSEWSECTAKCGERSV--VTRDIRC--SEDEKLCDPNTRPVGEKNCT 733
Query: 1594 SGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGP 1653
CD W W PC+ +CG+G R V C T + V + C + KP++ C
Sbjct: 734 GPPCDRQWTVSDWGPCSGSCGQGRTIRHVYC-KTSDGRVVPESQCQMETKPLAIHPCGDK 792
Query: 1654 SC 1655
+C
Sbjct: 793 NC 794
Score = 126 bits (316), Expect = 2e-28
Identities = 114/453 (25%), Positives = 171/453 (37%), Gaps = 106/453 (23%)
Query: 320 KTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRV-VPDH 378
+TR A K V Y+ W+ + PC+ TC G A CV R V V D
Sbjct: 550 RTRPKARKQGVSPADMYR-----WKLSSHEPCSATCTTGVMSAYAMCV--RYDGVEVDDS 602
Query: 379 YCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGI 438
YC +P+P + C+ C PRWE + W+ CS +CG G
Sbjct: 603 YCDAL---TRPEPVHEFCAGRECQ-----------------PRWETSSWSECSRTCGEGY 642
Query: 439 QRRSFVC-------VEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDC-PKWIAMEWSQC 490
Q R C + S++ ++ + E A +P+ +TC C P+W EWS+C
Sbjct: 643 QFRVVRCWKMLSPGFDSSVYSDLCEAAE-----AVRPEERKTCRNPACGPQWEMSEWSEC 697
Query: 491 TVTCG-RGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPW 549
T CG R + R + C E C+P + ++ C P PC
Sbjct: 698 TAKCGERSVVTRDIRC----SEDEKLCDPNTRPVGEKNCTGP-PC--------------- 737
Query: 550 LKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEEC 609
+ + W CS +CG G +R V C+ T +PE +C
Sbjct: 738 ---------------DRQWTVSDWGPCSGSCGQGRTIRHVYCK-----TSDGRVVPESQC 777
Query: 610 EGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIA 669
+ +P + C D W + C TC G ++ +
Sbjct: 778 Q----METKPLAIHPCG--------------DKNCPAHWLAQDWERCNTTCGRGVKKRLV 819
Query: 670 VCLHIQT--QQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRD 727
+C+ + QT + C + +PP S C PC +W+ W C+ TCGVG++ RD
Sbjct: 820 LCMELANGKPQTRSGPECGLAKKPPEES-TCFERPC-FKWYTSPWSECTKTCGVGVRMRD 877
Query: 728 VYCLHPGETPAPPEECRDEKPHALQACNQFDCP 760
V C + + KP QAC+ CP
Sbjct: 878 VKCYQGTDIVRGCDPL--VKPVGRQACDLQPCP 908
Score = 123 bits (308), Expect = 2e-27
Identities = 72/230 (31%), Positives = 101/230 (43%), Gaps = 20/230 (8%)
Query: 646 YDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPP 705
Y W+ + PC+ATC G A A+C+ + V+DS CD + RP + + C C P
Sbjct: 566 YRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE-VDDSYCDALTRPEPVHEFCAGRECQP 624
Query: 706 RWHVGSWGPCSATCGVGIQTRDVYC---LHPG-ETPAPPEECRDE---KPHALQACNQFD 758
RW SW CS TCG G Q R V C L PG ++ + C +P + C
Sbjct: 625 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
Query: 759 CPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQ-GPKASSHKSCART 817
C P W + EW +C+ CG R ++T + ++LC + K+C
Sbjct: 685 CGPQWEMSEWSECTAKCGE---------RSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGP 735
Query: 818 DCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLP 867
C V DW CS SCG G R C+ + GR +P S+ P
Sbjct: 736 PCDRQWTVSDWGPCSGSCGQGRTIRHVYCK--TSDGRVVPESQCQMETKP 783
Score = 116 bits (291), Expect = 2e-25
Identities = 92/375 (24%), Positives = 149/375 (39%), Gaps = 66/375 (17%)
Query: 421 RWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPK-VMQTCNLFDC 479
RW+ + CS +C G+ +CV + ++V++ C +P+ V + C +C
Sbjct: 567 RWKLSSHEPCSATCTTGVMSAYAMCVRY----DGVEVDDSYCDALTRPEPVHEFCAGREC 622
Query: 480 -PKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPK 538
P+W WS+C+ TCG G ++RVV C +P + + +P+
Sbjct: 623 QPRWETSSWSECSRTCGEGYQFRVVRCWKM-------LSPGFDSSVYSDLCEAAEAVRPE 675
Query: 539 EKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGP-GVQVREVKCRVLLTF 597
E+ + P E+ E WS C+ CG V R+++C
Sbjct: 676 ERKT--CRNPACGPQWEMSE--------------WSECTAKCGERSVVTRDIRCSE---- 715
Query: 598 TQTETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCT 657
E+ C+ P RP + C P R+ W + + PC+
Sbjct: 716 -------DEKLCD----PNTRPVGEKNCTGPPCDRQ--------------WTVSDWGPCS 750
Query: 658 ATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSA 717
+C G C + V +S C M +P A+ C + CP W W C+
Sbjct: 751 GSCGQGRTIRHVYC-KTSDGRVVPESQCQMETKPLAI-HPCGDKNCPAHWLAQDWERCNT 808
Query: 718 TCGVGIQTRDVYCLHPG----ETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQQCSR 773
TCG G++ R V C+ +T + PE +KP C + C W+ W +C++
Sbjct: 809 TCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFK-WYTSPWSECTK 867
Query: 774 TCGGGTQNRRVTCRQ 788
TCG G + R V C Q
Sbjct: 868 TCGVGVRMRDVKCYQ 882
Score = 115 bits (287), Expect = 5e-25
Identities = 86/288 (29%), Positives = 111/288 (38%), Gaps = 43/288 (14%)
Query: 1422 PPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIR 1481
P P WE WS C+A CG + +C E LCD +P+ G + C
Sbjct: 683 PACGPQWEMSEWSECTAKCGERSVVTRDIRC------SEDEKLCDPNTRPV-GEKNCTGP 735
Query: 1482 DCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFG 1541
C +W S W CS SCG+G R V CK + +VV C + +PL PC
Sbjct: 736 PCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDG----RVVPESQCQMETKPLAIHPCGD 791
Query: 1542 HPC-VQW--EPGNRCPGRCMGRAVRMQQRHTACQH-------NSSDSNCDDRKRPTLRRN 1591
C W + RC C GR V+ +R C S C K+P
Sbjct: 792 KNCPAHWLAQDWERCNTTC-GRGVK--KRLVLCMELANGKPQTRSGPECGLAKKPPEEST 848
Query: 1592 CTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIH----TRSCKPVAKRHCVQKKKPISW 1647
C C W+T PW CT CG G + R V C R C P+ K P+
Sbjct: 849 CFERPC-FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVK--------PVGR 899
Query: 1648 RHCLGPSC-----DRDCTDTTHY-CMFVKHLNLCSLDRYKQRCCQSCQ 1689
+ C C D C D C +NLC Y + CC+SC+
Sbjct: 900 QACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCR 947
Score = 107 bits (267), Expect = 1e-22
Identities = 77/233 (33%), Positives = 97/233 (41%), Gaps = 27/233 (11%)
Query: 1417 PTGEP----PPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPL 1472
P GE PP + W +W CS +CG G I+ C ++G+ V E+ C KPL
Sbjct: 726 PVGEKNCTGPPCDRQWTVSDWGPCSGSCGQ-GRTIRHVYCKTSDGRVVPESQCQMETKPL 784
Query: 1473 AGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDR 1532
A PC ++CPA W W +C+ +CG G R V C ANG Q S C +
Sbjct: 785 A-IHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMEL-ANGKPQTRSGPECGLAKK 842
Query: 1533 PLGRKPCFGHPCVQW--EPGNRCPGRCMGRAVRMQQRHTAC-QHNSSDSNCDDRKRPTLR 1589
P CF PC +W P + C C G VRM R C Q CD +P R
Sbjct: 843 PPEESTCFERPCFKWYTSPWSECTKTC-GVGVRM--RDVKCYQGTDIVRGCDPLVKPVGR 899
Query: 1590 RNCTSGAC-----DVCWHTGPWKPCTAA-----CGRGFQSRKVDCIHTRSCKP 1632
+ C C D P C A CG + S K C RSC+P
Sbjct: 900 QACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYS-KACC---RSCRP 948
Score = 89.4 bits (220), Expect = 3e-17
Identities = 60/204 (29%), Positives = 90/204 (44%), Gaps = 27/204 (13%)
Query: 338 PISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKP-KLKEC 396
P QW +D+ PC+ +CG G + C RVVP+ C ++ KP + C
Sbjct: 736 PCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSD-GRVVPESQCQ-----METKPLAIHPC 789
Query: 397 SMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQ 456
CP+ W W C+ +CG G+++R +C+E + +G+
Sbjct: 790 GDKNCPA-----------------HWLAQDWERCNTTCGRGVKKRLVLCMELA-NGKPQT 831
Query: 457 VEEWKCMYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGC 516
+C A KP TC C KW WS+CT TCG G+R R V C + V GC
Sbjct: 832 RSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGT-DIVRGC 890
Query: 517 NPQLKLHIKEECVI-PIPCYKPKE 539
+P +K ++ C + P P P +
Sbjct: 891 DPLVKPVGRQACDLQPCPTEPPDD 914
Score = 58.9 bits (141), Expect = 4e-08
Identities = 52/187 (27%), Positives = 72/187 (38%), Gaps = 23/187 (12%)
Query: 1486 RWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLG-RKPCFGHPC 1544
RW S CS +C G S C R V C RP + C G C
Sbjct: 567 RWKLSSHEPCSATCTTGVMSAYAMCVRYDG----VEVDDSYCDALTRPEPVHEFCAGREC 622
Query: 1545 V-QWEPGN--RCPGRC----MGRAVRMQQRHTACQHNSSDSN-CD--DRKRPTLRRNCTS 1594
+WE + C C R VR + + +S S+ C+ + RP R+ C +
Sbjct: 623 QPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRN 682
Query: 1595 GACDVCWHTGPWKPCTAACG-RGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGP 1653
AC W W CTA CG R +R + C ++ C +P+ ++C GP
Sbjct: 683 PACGPQWEMSEWSECTAKCGERSVVTRDIRCSED-------EKLCDPNTRPVGEKNCTGP 735
Query: 1654 SCDRDCT 1660
CDR T
Sbjct: 736 PCDRQWT 742
Score = 36.6 bits (83), Expect = 0.21
Identities = 23/75 (30%), Positives = 30/75 (40%), Gaps = 16/75 (21%)
Query: 78 WDAWGDWSDCSRTCGGGASYSLRRC-----------LTGRNCEGQNI----RYKTCSNHD 122
W+ WS+CSRTCG G + + RC + CE KTC N
Sbjct: 626 WET-SSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
Query: 123 CPPDAEDFRAQQCSA 137
C P E +C+A
Sbjct: 685 CGPQWEMSEWSECTA 699
Score = 35.0 bits (79), Expect = 0.62
Identities = 17/62 (27%), Positives = 25/62 (40%), Gaps = 2/62 (3%)
Query: 712 WGPCSATCGVGIQTRDVYCLHP--GETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQ 769
W CS +CG G+ +++ +CL P P Q C +CPP +
Sbjct: 56 WTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREE 115
Query: 770 QC 771
QC
Sbjct: 116 QC 117
Score = 35.0 bits (79), Expect = 0.62
Identities = 21/76 (27%), Positives = 32/76 (42%), Gaps = 11/76 (14%)
Query: 84 WSDCSRTCGGGASYSLRRCLTG----RNCEG--QNIRYKTCSNHDCPPDAEDFRAQ---- 133
WS+C++TCG G +C G R C+ + + + C CP + D Q
Sbjct: 862 WSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPG 921
Query: 134 -QCSAYNDVQYQGHYY 148
C+ V GH+Y
Sbjct: 922 TNCALAIKVNLCGHWY 937
Score = 33.1 bits (74), Expect = 2.3
Identities = 17/55 (30%), Positives = 26/55 (47%), Gaps = 2/55 (3%)
Query: 767 EWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPP 821
+W CSR+CGGG ++ C Q S + C G + ++ C +CPP
Sbjct: 55 KWTACSRSCGGGVTSQERHCLQQRRK-SVPGPGNRTCTG-TSKRYQLCRVQECPP 107
Score = 32.7 bits (73), Expect = 3.1
Identities = 12/26 (46%), Positives = 17/26 (65%)
Query: 423 EHNPWTACSVSCGGGIQRRSFVCVEE 448
E WTACS SCGGG+ + C+++
Sbjct: 52 EWTKWTACSRSCGGGVTSQERHCLQQ 77
Score = 31.6 bits (70), Expect = 6.8
Identities = 23/95 (24%), Positives = 34/95 (35%), Gaps = 16/95 (16%)
Query: 71 DEDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDF 130
D++ +W A DW C+ TCG G L C+ N + Q C PP+
Sbjct: 791 DKNCPAHWLAQ-DWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTC 849
Query: 131 RAQQCSAYNDVQYQGHYYEWLPRYNDPAAPCALKC 165
+ C ++W Y P + C C
Sbjct: 850 FERPC------------FKW---YTSPWSECTKTC 869
>gi|41281450 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 138 bits (347), Expect = 5e-32
Identities = 82/250 (32%), Positives = 117/250 (46%), Gaps = 38/250 (15%)
Query: 78 WDAWGDWSDCSRTCGGGASYSLRRCLT----------GRNCEGQNIRYKTCSNHDCPPDA 127
W W W+ CSR+CGGG + R CL R C G + RY+ C +CPPD
Sbjct: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
Query: 128 EDFRAQQCSAYNDVQYQGHYYEWLPRYND-----PAAPCALKC-HAQGQNLVVELAPKVL 181
FR +QC ++N Y G ++W P Y D + PC L C GQ +L
Sbjct: 110 RSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQR---QLMVPAR 166
Query: 182 DGTRCN-TDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSP 240
DGT C TD +C+SG C+ +GCD L S D CG+C GDGS+C +HV+
Sbjct: 167 DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSC--------THVTG 218
Query: 241 EKREEN-------VIAVPLGSRSVRITVKGPAHLFIESKTLQG---SKGEHSFNSPGVFL 290
R+ N V +P G+R ++I + + + G G + +SP F
Sbjct: 219 NYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFN 278
Query: 291 VENTTVEFQR 300
+ T V+++R
Sbjct: 279 IAGTVVKYRR 288
Score = 138 bits (347), Expect = 5e-32
Identities = 100/374 (26%), Positives = 148/374 (39%), Gaps = 62/374 (16%)
Query: 478 DCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKP 537
D +W C+ TC G+ +C+ + G V
Sbjct: 564 DMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEV------------------------ 599
Query: 538 KEKSPVEAKLPWLKQAQELEETRIATE-EPTFIPEPWSACSTTCGPGVQVREVKCRVLLT 596
+ S +A L + + + E E +P + WS CS TCG G Q R V+C +L+
Sbjct: 600 -DDSYCDA----LTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLS 654
Query: 597 FTQTETELPEEECEGPKL--PTERP-CLLEACDESPASRELDIPLPEDSETTYDWEYAGF 653
++ + + CE + P ER C AC WE + +
Sbjct: 655 -PGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQ-------------------WEMSEW 694
Query: 654 TPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWG 713
+ CTA C E V I+ + ++ LCD RP + C PC +W V WG
Sbjct: 695 SECTAKC----GERSVVTRDIRCSE--DEKLCDPNTRPVG-EKNCTGPPCDRQWTVSDWG 747
Query: 714 PCSATCGVGIQTRDVYCLHPGETPAPPEECRDE-KPHALQACNQFDCPPGWHIEEWQQCS 772
PCS +CG G R VYC P +C+ E KP A+ C +CP W ++W++C+
Sbjct: 748 PCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCN 807
Query: 773 RTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCS 832
TCG G + R V C +L E K +C C WS+C+
Sbjct: 808 TTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWY-TSPWSECT 866
Query: 833 VSCGVGIQRRKQVC 846
+CGVG++ R C
Sbjct: 867 KTCGVGVRMRDVKC 880
Score = 130 bits (326), Expect = 1e-29
Identities = 83/242 (34%), Positives = 109/242 (45%), Gaps = 11/242 (4%)
Query: 1419 GEPPPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPC 1478
G P W+ + CSATC G CV +G EV ++ CD L +P E C
Sbjct: 559 GVSPADMYRWKLSSHEPCSATCT-TGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFC 617
Query: 1479 NIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRAC--APKDRPLGR 1536
R+C RW TS WS+CS +CGEGY R V C + + G V C A RP R
Sbjct: 618 AGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEER 677
Query: 1537 KPCFGHPC-VQWEPG--NRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCT 1593
K C C QWE + C +C R+V R C + + CD RP +NCT
Sbjct: 678 KTCRNPACGPQWEMSEWSECTAKCGERSV--VTRDIRC--SEDEKLCDPNTRPVGEKNCT 733
Query: 1594 SGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGP 1653
CD W W PC+ +CG+G R V C T + V + C + KP++ C
Sbjct: 734 GPPCDRQWTVSDWGPCSGSCGQGRTIRHVYC-KTSDGRVVPESQCQMETKPLAIHPCGDK 792
Query: 1654 SC 1655
+C
Sbjct: 793 NC 794
Score = 126 bits (316), Expect = 2e-28
Identities = 114/453 (25%), Positives = 171/453 (37%), Gaps = 106/453 (23%)
Query: 320 KTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRV-VPDH 378
+TR A K V Y+ W+ + PC+ TC G A CV R V V D
Sbjct: 550 RTRPKARKQGVSPADMYR-----WKLSSHEPCSATCTTGVMSAYAMCV--RYDGVEVDDS 602
Query: 379 YCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGI 438
YC +P+P + C+ C PRWE + W+ CS +CG G
Sbjct: 603 YCDAL---TRPEPVHEFCAGRECQ-----------------PRWETSSWSECSRTCGEGY 642
Query: 439 QRRSFVC-------VEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDC-PKWIAMEWSQC 490
Q R C + S++ ++ + E A +P+ +TC C P+W EWS+C
Sbjct: 643 QFRVVRCWKMLSPGFDSSVYSDLCEAAE-----AVRPEERKTCRNPACGPQWEMSEWSEC 697
Query: 491 TVTCG-RGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPW 549
T CG R + R + C E C+P + ++ C P PC
Sbjct: 698 TAKCGERSVVTRDIRC----SEDEKLCDPNTRPVGEKNCTGP-PC--------------- 737
Query: 550 LKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEEC 609
+ + W CS +CG G +R V C+ T +PE +C
Sbjct: 738 ---------------DRQWTVSDWGPCSGSCGQGRTIRHVYCK-----TSDGRVVPESQC 777
Query: 610 EGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIA 669
+ +P + C D W + C TC G ++ +
Sbjct: 778 Q----METKPLAIHPCG--------------DKNCPAHWLAQDWERCNTTCGRGVKKRLV 819
Query: 670 VCLHIQT--QQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRD 727
+C+ + QT + C + +PP S C PC +W+ W C+ TCGVG++ RD
Sbjct: 820 LCMELANGKPQTRSGPECGLAKKPPEES-TCFERPC-FKWYTSPWSECTKTCGVGVRMRD 877
Query: 728 VYCLHPGETPAPPEECRDEKPHALQACNQFDCP 760
V C + + KP QAC+ CP
Sbjct: 878 VKCYQGTDIVRGCDPL--VKPVGRQACDLQPCP 908
Score = 123 bits (308), Expect = 2e-27
Identities = 72/230 (31%), Positives = 101/230 (43%), Gaps = 20/230 (8%)
Query: 646 YDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPP 705
Y W+ + PC+ATC G A A+C+ + V+DS CD + RP + + C C P
Sbjct: 566 YRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE-VDDSYCDALTRPEPVHEFCAGRECQP 624
Query: 706 RWHVGSWGPCSATCGVGIQTRDVYC---LHPG-ETPAPPEECRDE---KPHALQACNQFD 758
RW SW CS TCG G Q R V C L PG ++ + C +P + C
Sbjct: 625 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
Query: 759 CPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQ-GPKASSHKSCART 817
C P W + EW +C+ CG R ++T + ++LC + K+C
Sbjct: 685 CGPQWEMSEWSECTAKCGE---------RSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGP 735
Query: 818 DCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLP 867
C V DW CS SCG G R C+ + GR +P S+ P
Sbjct: 736 PCDRQWTVSDWGPCSGSCGQGRTIRHVYCK--TSDGRVVPESQCQMETKP 783
Score = 116 bits (291), Expect = 2e-25
Identities = 92/375 (24%), Positives = 149/375 (39%), Gaps = 66/375 (17%)
Query: 421 RWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPK-VMQTCNLFDC 479
RW+ + CS +C G+ +CV + ++V++ C +P+ V + C +C
Sbjct: 567 RWKLSSHEPCSATCTTGVMSAYAMCVRY----DGVEVDDSYCDALTRPEPVHEFCAGREC 622
Query: 480 -PKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPK 538
P+W WS+C+ TCG G ++RVV C +P + + +P+
Sbjct: 623 QPRWETSSWSECSRTCGEGYQFRVVRCWKM-------LSPGFDSSVYSDLCEAAEAVRPE 675
Query: 539 EKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGP-GVQVREVKCRVLLTF 597
E+ + P E+ E WS C+ CG V R+++C
Sbjct: 676 ERKT--CRNPACGPQWEMSE--------------WSECTAKCGERSVVTRDIRCSE---- 715
Query: 598 TQTETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCT 657
E+ C+ P RP + C P R+ W + + PC+
Sbjct: 716 -------DEKLCD----PNTRPVGEKNCTGPPCDRQ--------------WTVSDWGPCS 750
Query: 658 ATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSA 717
+C G C + V +S C M +P A+ C + CP W W C+
Sbjct: 751 GSCGQGRTIRHVYC-KTSDGRVVPESQCQMETKPLAI-HPCGDKNCPAHWLAQDWERCNT 808
Query: 718 TCGVGIQTRDVYCLHPG----ETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQQCSR 773
TCG G++ R V C+ +T + PE +KP C + C W+ W +C++
Sbjct: 809 TCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFK-WYTSPWSECTK 867
Query: 774 TCGGGTQNRRVTCRQ 788
TCG G + R V C Q
Sbjct: 868 TCGVGVRMRDVKCYQ 882
Score = 115 bits (287), Expect = 5e-25
Identities = 86/288 (29%), Positives = 111/288 (38%), Gaps = 43/288 (14%)
Query: 1422 PPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIR 1481
P P WE WS C+A CG + +C E LCD +P+ G + C
Sbjct: 683 PACGPQWEMSEWSECTAKCGERSVVTRDIRC------SEDEKLCDPNTRPV-GEKNCTGP 735
Query: 1482 DCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFG 1541
C +W S W CS SCG+G R V CK + +VV C + +PL PC
Sbjct: 736 PCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDG----RVVPESQCQMETKPLAIHPCGD 791
Query: 1542 HPC-VQW--EPGNRCPGRCMGRAVRMQQRHTACQH-------NSSDSNCDDRKRPTLRRN 1591
C W + RC C GR V+ +R C S C K+P
Sbjct: 792 KNCPAHWLAQDWERCNTTC-GRGVK--KRLVLCMELANGKPQTRSGPECGLAKKPPEEST 848
Query: 1592 CTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIH----TRSCKPVAKRHCVQKKKPISW 1647
C C W+T PW CT CG G + R V C R C P+ K P+
Sbjct: 849 CFERPC-FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVK--------PVGR 899
Query: 1648 RHCLGPSC-----DRDCTDTTHY-CMFVKHLNLCSLDRYKQRCCQSCQ 1689
+ C C D C D C +NLC Y + CC+SC+
Sbjct: 900 QACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCR 947
Score = 107 bits (267), Expect = 1e-22
Identities = 77/233 (33%), Positives = 97/233 (41%), Gaps = 27/233 (11%)
Query: 1417 PTGEP----PPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPL 1472
P GE PP + W +W CS +CG G I+ C ++G+ V E+ C KPL
Sbjct: 726 PVGEKNCTGPPCDRQWTVSDWGPCSGSCGQ-GRTIRHVYCKTSDGRVVPESQCQMETKPL 784
Query: 1473 AGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDR 1532
A PC ++CPA W W +C+ +CG G R V C ANG Q S C +
Sbjct: 785 A-IHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMEL-ANGKPQTRSGPECGLAKK 842
Query: 1533 PLGRKPCFGHPCVQW--EPGNRCPGRCMGRAVRMQQRHTAC-QHNSSDSNCDDRKRPTLR 1589
P CF PC +W P + C C G VRM R C Q CD +P R
Sbjct: 843 PPEESTCFERPCFKWYTSPWSECTKTC-GVGVRM--RDVKCYQGTDIVRGCDPLVKPVGR 899
Query: 1590 RNCTSGAC-----DVCWHTGPWKPCTAA-----CGRGFQSRKVDCIHTRSCKP 1632
+ C C D P C A CG + S K C RSC+P
Sbjct: 900 QACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYS-KACC---RSCRP 948
Score = 89.4 bits (220), Expect = 3e-17
Identities = 60/204 (29%), Positives = 90/204 (44%), Gaps = 27/204 (13%)
Query: 338 PISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKP-KLKEC 396
P QW +D+ PC+ +CG G + C RVVP+ C ++ KP + C
Sbjct: 736 PCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSD-GRVVPESQCQ-----METKPLAIHPC 789
Query: 397 SMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQ 456
CP+ W W C+ +CG G+++R +C+E + +G+
Sbjct: 790 GDKNCPA-----------------HWLAQDWERCNTTCGRGVKKRLVLCMELA-NGKPQT 831
Query: 457 VEEWKCMYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGC 516
+C A KP TC C KW WS+CT TCG G+R R V C + V GC
Sbjct: 832 RSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGT-DIVRGC 890
Query: 517 NPQLKLHIKEECVI-PIPCYKPKE 539
+P +K ++ C + P P P +
Sbjct: 891 DPLVKPVGRQACDLQPCPTEPPDD 914
Score = 58.9 bits (141), Expect = 4e-08
Identities = 52/187 (27%), Positives = 72/187 (38%), Gaps = 23/187 (12%)
Query: 1486 RWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLG-RKPCFGHPC 1544
RW S CS +C G S C R V C RP + C G C
Sbjct: 567 RWKLSSHEPCSATCTTGVMSAYAMCVRYDG----VEVDDSYCDALTRPEPVHEFCAGREC 622
Query: 1545 V-QWEPGN--RCPGRC----MGRAVRMQQRHTACQHNSSDSN-CD--DRKRPTLRRNCTS 1594
+WE + C C R VR + + +S S+ C+ + RP R+ C +
Sbjct: 623 QPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRN 682
Query: 1595 GACDVCWHTGPWKPCTAACG-RGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGP 1653
AC W W CTA CG R +R + C ++ C +P+ ++C GP
Sbjct: 683 PACGPQWEMSEWSECTAKCGERSVVTRDIRCSED-------EKLCDPNTRPVGEKNCTGP 735
Query: 1654 SCDRDCT 1660
CDR T
Sbjct: 736 PCDRQWT 742
Score = 36.6 bits (83), Expect = 0.21
Identities = 23/75 (30%), Positives = 30/75 (40%), Gaps = 16/75 (21%)
Query: 78 WDAWGDWSDCSRTCGGGASYSLRRC-----------LTGRNCEGQNI----RYKTCSNHD 122
W+ WS+CSRTCG G + + RC + CE KTC N
Sbjct: 626 WET-SSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
Query: 123 CPPDAEDFRAQQCSA 137
C P E +C+A
Sbjct: 685 CGPQWEMSEWSECTA 699
Score = 35.0 bits (79), Expect = 0.62
Identities = 17/62 (27%), Positives = 25/62 (40%), Gaps = 2/62 (3%)
Query: 712 WGPCSATCGVGIQTRDVYCLHP--GETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQ 769
W CS +CG G+ +++ +CL P P Q C +CPP +
Sbjct: 56 WTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREE 115
Query: 770 QC 771
QC
Sbjct: 116 QC 117
Score = 35.0 bits (79), Expect = 0.62
Identities = 21/76 (27%), Positives = 32/76 (42%), Gaps = 11/76 (14%)
Query: 84 WSDCSRTCGGGASYSLRRCLTG----RNCEG--QNIRYKTCSNHDCPPDAEDFRAQ---- 133
WS+C++TCG G +C G R C+ + + + C CP + D Q
Sbjct: 862 WSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPG 921
Query: 134 -QCSAYNDVQYQGHYY 148
C+ V GH+Y
Sbjct: 922 TNCALAIKVNLCGHWY 937
Score = 33.1 bits (74), Expect = 2.3
Identities = 17/55 (30%), Positives = 26/55 (47%), Gaps = 2/55 (3%)
Query: 767 EWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPP 821
+W CSR+CGGG ++ C Q S + C G + ++ C +CPP
Sbjct: 55 KWTACSRSCGGGVTSQERHCLQQRRK-SVPGPGNRTCTG-TSKRYQLCRVQECPP 107
Score = 32.7 bits (73), Expect = 3.1
Identities = 12/26 (46%), Positives = 17/26 (65%)
Query: 423 EHNPWTACSVSCGGGIQRRSFVCVEE 448
E WTACS SCGGG+ + C+++
Sbjct: 52 EWTKWTACSRSCGGGVTSQERHCLQQ 77
Score = 31.6 bits (70), Expect = 6.8
Identities = 23/95 (24%), Positives = 34/95 (35%), Gaps = 16/95 (16%)
Query: 71 DEDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDF 130
D++ +W A DW C+ TCG G L C+ N + Q C PP+
Sbjct: 791 DKNCPAHWLAQ-DWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTC 849
Query: 131 RAQQCSAYNDVQYQGHYYEWLPRYNDPAAPCALKC 165
+ C ++W Y P + C C
Sbjct: 850 FERPC------------FKW---YTSPWSECTKTC 869
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.440
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 78,457,334
Number of Sequences: 37866
Number of extensions: 4136160
Number of successful extensions: 17497
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 196
Number of HSP's successfully gapped in prelim test: 234
Number of HSP's that attempted gapping in prelim test: 10206
Number of HSP's gapped (non-prelim): 3983
length of query: 1691
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1575
effective length of database: 13,855,062
effective search space: 21821722650
effective search space used: 21821722650
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.