Search of human proteins with 89191861

Search of human proteins with 89191861

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
         (400 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]             808   0.0  
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]             727   0.0  
gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]         391   e-109
gi|4503385 dopamine receptor D2 isoform long [Homo sapiens]           384   e-106
gi|32483397 dopamine receptor D4 [Homo sapiens]                       256   3e-68
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa...   209   3e-54
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap...   195   5e-50
gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]              194   1e-49
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]                192   3e-49
gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens]               191   8e-49
gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens]               191   8e-49
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]    188   6e-48
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]    188   6e-48
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]    188   6e-48
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]    188   6e-48
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]                187   1e-47
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]   184   2e-46
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]   184   2e-46
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]    184   2e-46
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap...   182   4e-46
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa...   181   8e-46
gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo sap...   171   8e-43
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap...   166   3e-41
gi|4557265 beta-1-adrenergic receptor [Homo sapiens]                  165   8e-41
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]               155   5e-38
gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]            155   5e-38
gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo s...   154   2e-37
gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi...   147   2e-35
gi|194018562 histamine receptor H3 [Homo sapiens]                     137   2e-32
gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens]         137   2e-32

>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
          Length = 400

 Score =  808 bits (2086), Expect = 0.0
 Identities = 400/400 (100%), Positives = 400/400 (100%)

Query: 1   MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL 60
           MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
Sbjct: 1   MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL 60

Query: 61  QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN 120
           QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
Sbjct: 61  QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN 120

Query: 121 LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV 180
           LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
Sbjct: 121 LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV 180

Query: 181 CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ 240
           CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
Sbjct: 181 CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ 240

Query: 241 QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK 300
           QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
Sbjct: 241 QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK 300

Query: 301 LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV 360
           LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
Sbjct: 301 LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV 360

Query: 361 SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 400
           SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
Sbjct: 361 SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 400


>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
          Length = 367

 Score =  727 bits (1877), Expect = 0.0
 Identities = 366/400 (91%), Positives = 367/400 (91%), Gaps = 33/400 (8%)

Query: 1   MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL 60
           MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
Sbjct: 1   MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL 60

Query: 61  QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN 120
           QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
Sbjct: 61  QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN 120

Query: 121 LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV 180
           LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
Sbjct: 121 LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV 180

Query: 181 CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ 240
           CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
Sbjct: 181 CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ 240

Query: 241 QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK 300
           QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSL              
Sbjct: 241 QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSL-------------- 286

Query: 301 LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV 360
                              +PLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
Sbjct: 287 -------------------MPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV 327

Query: 361 SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 400
           SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
Sbjct: 328 SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367


>gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
          Length = 414

 Score =  391 bits (1004), Expect = e-109
 Identities = 221/399 (55%), Positives = 268/399 (67%), Gaps = 24/399 (6%)

Query: 19  NSTGASQARPHA-YYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLL 77
           N +     RPH  YYA     LI  IVFGN LVCMAV +E+ALQTTTNYL+VSLAVADLL
Sbjct: 23  NGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLL 82

Query: 78  VATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVH 137
           VATLVMPWVVYLEV  G W FSRI CD+FVTLDVMMCTASILNLCAISIDRYTAV MP+ 
Sbjct: 83  VATLVMPWVVYLEVV-GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPML 141

Query: 138 YQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSF 197
           Y   T  SS RRV +MI+ VWVL+F +SCPLLFG N   D   C I+NP FV+YSS+VSF
Sbjct: 142 Y--NTRYSSKRRVTVMISIVWVLSFTISCPLLFGLN-NADQNECIIANPAFVVYSSIVSF 198

Query: 198 YLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYS 257
           Y+PF VT+LVY +IY+VL+ RRRKR+ T+++S+        P +  +     LE++   S
Sbjct: 199 YVPFIVTLLVYIKIYIVLR-RRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSS 257

Query: 258 ICQDTALGGPGFQERGGELKREEKTRNSLSPT--------------IAPKLS--LEVRKL 301
                            +L   + + + L  T                PK++   E++ +
Sbjct: 258 TSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTM 317

Query: 302 SNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVS 361
            NG+  TSLK    +      +EKKATQM+AIVLG FI+CWLPFF+TH+LN HC  C++ 
Sbjct: 318 PNGKTRTSLKTMSRRKLS-QQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD-CNIP 375

Query: 362 PELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 400
           P LYSA TWLGYVNSA+NP+IYTTFNIEFRKAFLKIL C
Sbjct: 376 PVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 414


>gi|4503385 dopamine receptor D2 isoform long [Homo sapiens]
          Length = 443

 Score =  384 bits (985), Expect = e-106
 Identities = 228/434 (52%), Positives = 272/434 (62%), Gaps = 65/434 (14%)

Query: 19  NSTGASQARPHA-YYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLL 77
           N +     RPH  YYA     LI  IVFGN LVCMAV +E+ALQTTTNYL+VSLAVADLL
Sbjct: 23  NGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLL 82

Query: 78  VATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVH 137
           VATLVMPWVVYLEV  G W FSRI CD+FVTLDVMMCTASILNLCAISIDRYTAV MP+ 
Sbjct: 83  VATLVMPWVVYLEVV-GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPML 141

Query: 138 YQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSF 197
           Y   T  SS RRV +MI+ VWVL+F +SCPLLFG N   D   C I+NP FV+YSS+VSF
Sbjct: 142 Y--NTRYSSKRRVTVMISIVWVLSFTISCPLLFGLN-NADQNECIIANPAFVVYSSIVSF 198

Query: 198 YLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYS 257
           Y+PF VT+LVY +IY+VL+ RRRKR+ T+++S+        P +     P  ++L     
Sbjct: 199 YVPFIVTLLVYIKIYIVLR-RRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKL----- 252

Query: 258 ICQDTALGGPGF---------QERGGELKRE--------EKTRNSLSPTIAPKLSL---- 296
            C         F           R  EL+ E        E+TR S  P    +L+L    
Sbjct: 253 -CTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPS 311

Query: 297 ------------------------------EVRKLSNGRLSTSLKLGPLQPRGVPLREKK 326
                                         E++ + NG+  TSLK    +      +EKK
Sbjct: 312 HHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLS-QQKEKK 370

Query: 327 ATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTF 386
           ATQM+AIVLG FI+CWLPFF+TH+LN HC  C++ P LYSA TWLGYVNSA+NP+IYTTF
Sbjct: 371 ATQMLAIVLGVFIICWLPFFITHILNIHCD-CNIPPVLYSAFTWLGYVNSAVNPIIYTTF 429

Query: 387 NIEFRKAFLKILSC 400
           NIEFRKAFLKIL C
Sbjct: 430 NIEFRKAFLKILHC 443


>gi|32483397 dopamine receptor D4 [Homo sapiens]
          Length = 419

 Score =  256 bits (653), Expect = 3e-68
 Identities = 160/415 (38%), Positives = 212/415 (51%), Gaps = 52/415 (12%)

Query: 16  GAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVAD 75
           GA     A  A   A   +    LI A++ GN LVC++V  ERALQT TN  +VSLA AD
Sbjct: 21  GASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAAD 80

Query: 76  LLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMP 135
           LL+A LV+P  VY EV GG W  S   CD  + +DVM+CTASI NLCAIS+DR+ AV +P
Sbjct: 81  LLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVP 140

Query: 136 VHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTT--GDPTVCSISNPDFVIYSS 193
           + Y     Q   RR  L+I A W+L+ AV+ P+L G N     DP VC + + D+V+YSS
Sbjct: 141 LRYNR---QGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSS 197

Query: 194 VVSFYLPFGVTVLVYARIYVVLKQ---RRRKRILTRQ----------------------- 227
           V SF+LP  + +L+Y   +  L++    RR ++  R                        
Sbjct: 198 VCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDP 257

Query: 228 -NSQCNSVRPGFPQQTLSPDPAHLELKRYYSIC-QDTALGGPGF--QERGGELKREEKTR 283
               C    PG P+    PD A          C  D A   PG      G      +  R
Sbjct: 258 CGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVR 317

Query: 284 NSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWL 343
            +  P   P+   + R+    +++               RE+KA +++ +V+GAF++CW 
Sbjct: 318 AAALP---PQTPPQTRRRRRAKITG--------------RERKAMRVLPVVVGAFLLCWT 360

Query: 344 PFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKIL 398
           PFF+ H+    C  C V P L SA TWLGYVNSALNPVIYT FN EFR  F K L
Sbjct: 361 PFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKAL 415


>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
           sapiens]
          Length = 422

 Score =  209 bits (533), Expect = 3e-54
 Identities = 134/411 (32%), Positives = 205/411 (49%), Gaps = 46/411 (11%)

Query: 19  NSTGASQARP--HAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADL 76
           N+TG S          +L    LI   V GN  V  A+  ER+LQ   NYL+ SLAV DL
Sbjct: 24  NTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDL 83

Query: 77  LVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPV 136
           +V+ LV+P     +V    W   ++ CD+F+ LDV+ CT+SIL+LCAI++DRY A+  P+
Sbjct: 84  MVSVLVLPMAALYQVLNK-WTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPI 142

Query: 137 HYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNT---TGDPTVCSIS-NPDFVIYS 192
            Y     + + RR A +I+  W++ F +S P + G+ T     DP  C+IS +  + IYS
Sbjct: 143 DY---VNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYS 199

Query: 193 SVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAH--- 249
           +  +FY+P  + +++Y RI+   + R RK +   + +  ++     P    +P P     
Sbjct: 200 TFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASP----APQPKKSVN 255

Query: 250 -----------LELKRYYSICQDTAL--GGPGFQ------ERGGELKREEKTRNSLSPTI 290
                      +E K   ++C + A+  G  G         R G  K      +   PT 
Sbjct: 256 GESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTP 315

Query: 291 APKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHV 350
               S E +   N      + L          RE+K  + + I++G FI+CWLPFF+  +
Sbjct: 316 CAPASFERKNERNAEAKRKMALA---------RERKTVKTLGIIMGTFILCWLPFFIVAL 366

Query: 351 LNTHCQ-TCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 400
           +   C+ +CH+   L +   WLGY NS LNPVIY  FN +F+ AF KI+ C
Sbjct: 367 VLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKC 417


>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
           sapiens]
          Length = 377

 Score =  195 bits (496), Expect = 5e-50
 Identities = 127/373 (34%), Positives = 189/373 (50%), Gaps = 50/373 (13%)

Query: 33  ALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVT 92
           A+    + LA V  N  V   +L  R L T  NYL+ SLA  DLLV+ LVMP  +   +T
Sbjct: 42  AVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTIT 101

Query: 93  GGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVAL 152
              WNF +I CD++++ D+  CTASIL+LC I++DRY A+   + Y   + + +    A 
Sbjct: 102 H-TWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEY---SKRRTAGHAAT 157

Query: 153 MITAVWVLAFAVSCPLLFGFNTTG----DPTVCSISNPDFVIYSSVVSFYLPFGVTVLVY 208
           MI  VW ++  +S P LF             + + S   + IYS+  +FY+P  + +++Y
Sbjct: 158 MIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILY 217

Query: 209 ARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPG 268
            RIY    +  R RIL                     +P  L  KR+ +    T   G  
Sbjct: 218 GRIY----RAARNRIL---------------------NPPSLYGKRFTTAHLITGSAGSS 252

Query: 269 FQERGGELKREEKTRNSLSPTI--APKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKK 326
                  L  E  + ++ SP      K+ L    L   R+S +             RE+K
Sbjct: 253 LCSLNSSL-HEGHSHSAGSPLFFNHVKIKLADSALERKRISAA-------------RERK 298

Query: 327 ATQMVAIVLGAFIVCWLPFFLTHVLNTHCQ-TCHVSPELYSATTWLGYVNSALNPVIYTT 385
           AT+++ I+LGAFI+CWLPFF+  ++   C+ +C + P L+   TWLGY+NS +NP+IYT 
Sbjct: 299 ATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTV 358

Query: 386 FNIEFRKAFLKIL 398
           FN EFR+AF KI+
Sbjct: 359 FNEEFRQAFQKIV 371


>gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]
          Length = 465

 Score =  194 bits (493), Expect = 1e-49
 Identities = 153/456 (33%), Positives = 219/456 (48%), Gaps = 73/456 (16%)

Query: 1   MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCA-----LILAIVFGNGLVCMAVL 55
           M SL   +G+ ++  G E   G ++A P++             L+L  VFGN LV +AV 
Sbjct: 16  MGSLQPDAGNASWN-GTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVF 74

Query: 56  KERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCT 115
             RAL+   N  +VSLA AD+LVATLV+P+ +  EV G  W F +  C++++ LDV+ CT
Sbjct: 75  TSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMG-YWYFGKAWCEIYLALDVLFCT 133

Query: 116 ASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTT 175
           +SI++LCAIS+DRY ++   + Y     + + RR+  +I  VWV++  +S P L      
Sbjct: 134 SSIVHLCAISLDRYWSITQAIEYNL---KRTPRRIKAIIITVWVISAVISFPPLISIEKK 190

Query: 176 G--------DPTVCSISNPD-FVIYSSVVSFYLPFGVTVLVYARIYVVLKQR-------- 218
           G        +P  C I++   +VI S + SF+ P  + +LVY RIY + K+R        
Sbjct: 191 GGGGGPQPAEPR-CEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRR 249

Query: 219 -------------RRKRILTRQNS-------------QCNSVRPGFPQQTLSPDPAHLEL 252
                        RR   L  + S             Q N   PG P      D   L+L
Sbjct: 250 GPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGA-PGEPAPAGPRDTDALDL 308

Query: 253 KRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKL 312
           +   S        GP   ERG   K + +     +  + P  SL  R      + T    
Sbjct: 309 EESSSSDHAERPPGPRRPERGPRGKGKAR-----ASQVKPGDSLPRRGPGATGIGTP-AA 362

Query: 313 GPLQP----------RGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSP 362
           GP +           RG   REK+ T ++A+V+G F+VCW PFF T+ L      C V  
Sbjct: 363 GPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLT--AVGCSVPR 420

Query: 363 ELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKIL 398
            L+    W GY NS+LNPVIYT FN +FR+AF KIL
Sbjct: 421 TLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKIL 456


>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
          Length = 572

 Score =  192 bits (489), Expect = 3e-49
 Identities = 127/366 (34%), Positives = 181/366 (49%), Gaps = 54/366 (14%)

Query: 38  ALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWN 97
           A IL  V GN LV ++V   R LQT TNY +V+LAVADLL++  V+P+   +EV G  W 
Sbjct: 105 AFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLG-FWA 163

Query: 98  FSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAV 157
           F R  CDV+  +DV+ CTASIL+LC IS+DRY  V   + Y     +   R+ A ++  +
Sbjct: 164 FGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTE---RKAAAILALL 220

Query: 158 WVLAFAVSCPLLFGFN--TTGDPTVCSISNP-DFVIYSSVVSFYLPFGVTVLVYARIYVV 214
           WV+A  VS   L G+      D   C I+    + ++SSV SFYLP  V V++Y R+YVV
Sbjct: 221 WVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVV 280

Query: 215 LKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGG 274
            +   R            S+  G  ++        L +      C+  A G  G      
Sbjct: 281 ARSTTR------------SLEAGVKRERGKASEVVLRIH-----CRGAATGADG------ 317

Query: 275 ELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIV 334
                   R++   T    LS+ + K S                    REKKA + +AIV
Sbjct: 318 ----AHGMRSAKGHTFRSSLSVRLLKFS--------------------REKKAAKTLAIV 353

Query: 335 LGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAF 394
           +G F++CW PFF    L +       S  ++    WLGY NS +NP+IY   + EF++AF
Sbjct: 354 VGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAF 413

Query: 395 LKILSC 400
           L++L C
Sbjct: 414 LRLLRC 419


>gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens]
          Length = 462

 Score =  191 bits (486), Expect = 8e-49
 Identities = 144/427 (33%), Positives = 207/427 (48%), Gaps = 48/427 (11%)

Query: 16  GAENSTGASQARPHAYYALSYCA--------LILAIVFGNGLVCMAVLKERALQTTTNYL 67
           G  N++GAS   P   Y+    A        LI+  V GN LV +AVL  RAL+   N  
Sbjct: 30  GVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLF 89

Query: 68  VVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISID 127
           +VSLA AD+LVATLVMP+ +  E+    W F ++ C V++ LDV+ CT+SI++LCAIS+D
Sbjct: 90  LVSLASADILVATLVMPFSLANELMA-YWYFGQVWCGVYLALDVLFCTSSIVHLCAISLD 148

Query: 128 RYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV---CSIS 184
           RY +V   V Y     + + RRV   I AVW+++  +S P L       D      C ++
Sbjct: 149 RYWSVTQAVEYNL---KRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLN 205

Query: 185 NPDFVIYSSVV-SFYLPFGVTVLVYARIYVVLKQRRR----KRILTRQNSQCNSVRPGFP 239
           +  + I SS + SF+ P  +  LVYARIY V K R R    KR     +    +   G  
Sbjct: 206 DETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLG 265

Query: 240 QQT-------LSPDPAHLELKRYYSICQDT----ALGGPGFQERGGELKREEKTRNSLSP 288
                      +P PA +E     +  +      AL   G +  G E            P
Sbjct: 266 AAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGP 325

Query: 289 TIAPKLSLEVRKL--SNGRLSTS--------------LKLGPLQPRGVPLREKKATQMVA 332
             A   +L   +     GRLS +               +    + +    REK+ T ++A
Sbjct: 326 GAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLA 385

Query: 333 IVLGAFIVCWLPFFLTHVLNTHC-QTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFR 391
           +V+G F++CW PFF ++ L   C + C V   L+    W+GY NS+LNPVIYT FN +FR
Sbjct: 386 VVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFR 445

Query: 392 KAFLKIL 398
           ++F  IL
Sbjct: 446 RSFKHIL 452


>gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens]
          Length = 450

 Score =  191 bits (486), Expect = 8e-49
 Identities = 135/433 (31%), Positives = 211/433 (48%), Gaps = 68/433 (15%)

Query: 30  AYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYL 89
           A  A +   LIL  +FGN LV +AVL  R+L+   N  +VSLA AD+LVATL++P+ +  
Sbjct: 13  AAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLAN 72

Query: 90  EVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRR 149
           E+ G  W F R  C+V++ LDV+ CT+SI++LCAIS+DRY AV   + Y     + + RR
Sbjct: 73  ELLG-YWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEY---NSKRTPRR 128

Query: 150 VALMITAVWVLAFAVSCPLLF-----GFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVT 204
           +  +I  VW++A  +S P L      G    G P         +++ SS+ SF+ P  + 
Sbjct: 129 IKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIM 188

Query: 205 VLVYARIYVVLKQRRRK---------------------------------RILTRQNSQC 231
           +LVY RIY++ K+  R+                                  + + +    
Sbjct: 189 ILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNG 248

Query: 232 NSVRPGFPQQTLSP-DPAHLELKRYYSICQDTALG------GPGFQERGGELKREEKTRN 284
           +S   G  ++  +P D     L   ++   ++  G      G   ++   E + EE+   
Sbjct: 249 HSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEE 308

Query: 285 SLSPTIAP-----KLSLEVRKLSNGRLSTSLKLGPLQPRGVP-------------LREKK 326
              P   P       S  +++    R+  +L+   L  RGV               REK+
Sbjct: 309 ECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKR 368

Query: 327 ATQMVAIVLGAFIVCWLPFFLTHVLNTHC-QTCHVSPELYSATTWLGYVNSALNPVIYTT 385
            T ++A+V+G F++CW PFF ++ L   C + C V   L+    W+GY NS+LNPVIYT 
Sbjct: 369 FTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTI 428

Query: 386 FNIEFRKAFLKIL 398
           FN +FR+AF +IL
Sbjct: 429 FNQDFRRAFRRIL 441


>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
          Length = 455

 Score =  188 bits (478), Expect = 6e-48
 Identities = 121/363 (33%), Positives = 181/363 (49%), Gaps = 60/363 (16%)

Query: 39  LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
           LIL  V GN LV ++V   R L + T+Y +V+LAVADLL+ + V+P+    EV G  W F
Sbjct: 36  LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAF 94

Query: 99  SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
            R+ C+++  +DV+ CTASI+ LC ISIDRY  V  P+ Y     Q   RR  + +  VW
Sbjct: 95  GRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ---RRGLMALLCVW 151

Query: 159 VLAFAVSCPLLFGFNTTG--DPTVCSIS-NPDFVIYSSVVSFYLPFGVTVLVYARIYVVL 215
            L+  +S   LFG+      D T+C I+  P +V++S++ SFYLP  + +++Y R+YVV 
Sbjct: 152 ALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVA 211

Query: 216 KQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGE 275
           K+  R             ++ G        +   L + R     ++   GG G       
Sbjct: 212 KRESR------------GLKSGLKTDKSDSEQVTLRIHR-----KNAPAGGSGM------ 248

Query: 276 LKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVL 335
                KT+           S+ + K S                    REKKA + + IV+
Sbjct: 249 --ASAKTKT--------HFSVRLLKFS--------------------REKKAAKTLGIVV 278

Query: 336 GAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFL 395
           G F++CWLPFFL   + +       S  ++    WLGY+NS +NP+IY   + EF+KAF 
Sbjct: 279 GCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQ 338

Query: 396 KIL 398
            +L
Sbjct: 339 NVL 341


>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
          Length = 466

 Score =  188 bits (478), Expect = 6e-48
 Identities = 121/363 (33%), Positives = 181/363 (49%), Gaps = 60/363 (16%)

Query: 39  LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
           LIL  V GN LV ++V   R L + T+Y +V+LAVADLL+ + V+P+    EV G  W F
Sbjct: 36  LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAF 94

Query: 99  SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
            R+ C+++  +DV+ CTASI+ LC ISIDRY  V  P+ Y     Q   RR  + +  VW
Sbjct: 95  GRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ---RRGLMALLCVW 151

Query: 159 VLAFAVSCPLLFGFNTTG--DPTVCSIS-NPDFVIYSSVVSFYLPFGVTVLVYARIYVVL 215
            L+  +S   LFG+      D T+C I+  P +V++S++ SFYLP  + +++Y R+YVV 
Sbjct: 152 ALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVA 211

Query: 216 KQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGE 275
           K+  R             ++ G        +   L + R     ++   GG G       
Sbjct: 212 KRESR------------GLKSGLKTDKSDSEQVTLRIHR-----KNAPAGGSGM------ 248

Query: 276 LKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVL 335
                KT+           S+ + K S                    REKKA + + IV+
Sbjct: 249 --ASAKTKT--------HFSVRLLKFS--------------------REKKAAKTLGIVV 278

Query: 336 GAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFL 395
           G F++CWLPFFL   + +       S  ++    WLGY+NS +NP+IY   + EF+KAF 
Sbjct: 279 GCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQ 338

Query: 396 KIL 398
            +L
Sbjct: 339 NVL 341


>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
          Length = 475

 Score =  188 bits (478), Expect = 6e-48
 Identities = 121/363 (33%), Positives = 181/363 (49%), Gaps = 60/363 (16%)

Query: 39  LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
           LIL  V GN LV ++V   R L + T+Y +V+LAVADLL+ + V+P+    EV G  W F
Sbjct: 36  LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAF 94

Query: 99  SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
            R+ C+++  +DV+ CTASI+ LC ISIDRY  V  P+ Y     Q   RR  + +  VW
Sbjct: 95  GRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ---RRGLMALLCVW 151

Query: 159 VLAFAVSCPLLFGFNTTG--DPTVCSIS-NPDFVIYSSVVSFYLPFGVTVLVYARIYVVL 215
            L+  +S   LFG+      D T+C I+  P +V++S++ SFYLP  + +++Y R+YVV 
Sbjct: 152 ALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVA 211

Query: 216 KQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGE 275
           K+  R             ++ G        +   L + R     ++   GG G       
Sbjct: 212 KRESR------------GLKSGLKTDKSDSEQVTLRIHR-----KNAPAGGSGM------ 248

Query: 276 LKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVL 335
                KT+           S+ + K S                    REKKA + + IV+
Sbjct: 249 --ASAKTKT--------HFSVRLLKFS--------------------REKKAAKTLGIVV 278

Query: 336 GAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFL 395
           G F++CWLPFFL   + +       S  ++    WLGY+NS +NP+IY   + EF+KAF 
Sbjct: 279 GCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQ 338

Query: 396 KIL 398
            +L
Sbjct: 339 NVL 341


>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
          Length = 429

 Score =  188 bits (478), Expect = 6e-48
 Identities = 121/363 (33%), Positives = 181/363 (49%), Gaps = 60/363 (16%)

Query: 39  LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
           LIL  V GN LV ++V   R L + T+Y +V+LAVADLL+ + V+P+    EV G  W F
Sbjct: 36  LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAF 94

Query: 99  SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
            R+ C+++  +DV+ CTASI+ LC ISIDRY  V  P+ Y     Q   RR  + +  VW
Sbjct: 95  GRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ---RRGLMALLCVW 151

Query: 159 VLAFAVSCPLLFGFNTTG--DPTVCSIS-NPDFVIYSSVVSFYLPFGVTVLVYARIYVVL 215
            L+  +S   LFG+      D T+C I+  P +V++S++ SFYLP  + +++Y R+YVV 
Sbjct: 152 ALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVA 211

Query: 216 KQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGE 275
           K+  R             ++ G        +   L + R     ++   GG G       
Sbjct: 212 KRESR------------GLKSGLKTDKSDSEQVTLRIHR-----KNAPAGGSGM------ 248

Query: 276 LKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVL 335
                KT+           S+ + K S                    REKKA + + IV+
Sbjct: 249 --ASAKTKT--------HFSVRLLKFS--------------------REKKAAKTLGIVV 278

Query: 336 GAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFL 395
           G F++CWLPFFL   + +       S  ++    WLGY+NS +NP+IY   + EF+KAF 
Sbjct: 279 GCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQ 338

Query: 396 KIL 398
            +L
Sbjct: 339 NVL 341


>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
          Length = 520

 Score =  187 bits (476), Expect = 1e-47
 Identities = 125/366 (34%), Positives = 188/366 (51%), Gaps = 57/366 (15%)

Query: 38  ALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWN 97
           A IL  + GN LV ++V   R L+T TNY +V+LA+ADLL++  V+P+   LEV G  W 
Sbjct: 54  AFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLG-YWV 112

Query: 98  FSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAV 157
             RI CD++  +DV+ CTASIL+LCAISIDRY  V   + Y     +   R+  L + +V
Sbjct: 113 LGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTR---RKAILALLSV 169

Query: 158 WVLAFAVSCPLLFGFN--TTGDPTVCSIS-NPDFVIYSSVVSFYLPFGVTVLVYARIYVV 214
           WVL+  +S   L G+      D   C ++  P + ++SS+ SFY+P  V +++Y R+Y+V
Sbjct: 170 WVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIV 229

Query: 215 LKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGG 274
            K+       T +N +   ++     + L+     +  K ++   +DT            
Sbjct: 230 AKR-------TTKNLEAGVMKEMSNSKELT---LRIHSKNFH---EDT------------ 264

Query: 275 ELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIV 334
                              LS    K  N R S ++KL          REKKA + + IV
Sbjct: 265 -------------------LSSTKAKGHNPRSSIAVKLFKFS------REKKAAKTLGIV 299

Query: 335 LGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAF 394
           +G FI+CWLPFF+   L +   T      ++    WLGY NS LNP+IY   + EF++AF
Sbjct: 300 VGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAF 359

Query: 395 LKILSC 400
           ++IL C
Sbjct: 360 VRILGC 365


>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
          Length = 432

 Score =  184 bits (466), Expect = 2e-46
 Identities = 129/367 (35%), Positives = 181/367 (49%), Gaps = 61/367 (16%)

Query: 39  LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
           + L  + GN LV ++V   + L+  +NYL+VSLA+ADL VA  VMP+V   ++ GG W F
Sbjct: 91  ITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIF 150

Query: 99  SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
               C+VF+ +DVM CTASI+ LC ISIDRY  +  P+ Y     + + + +A MI +VW
Sbjct: 151 GHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTY---PVRQNGKCMAKMILSVW 207

Query: 159 VLAFAVSCPLLFGF-NTTGDPTVCSISNP-DFVIYSSVVSFYLPFGVTVLVYARIYVVLK 216
           +L+ +++ P LFG+     D  VC IS    + IYS+ V+FY+P  V + +Y +IY   +
Sbjct: 208 LLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAAR 267

Query: 217 QRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGEL 276
           +   K              PGFP+  + PD                AL G          
Sbjct: 268 KSAAKHKF-----------PGFPR--VEPDSV-------------IALNG---------- 291

Query: 277 KREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLG 336
                           KL  EV + +N  LS  LK    +   +  RE+KA   + I++G
Sbjct: 292 --------------IVKLQKEVEECAN--LSRLLK-HERKNISIFKREQKAATTLGIIVG 334

Query: 337 AFIVCWLPFFLTHVLNTH-CQT-CHVSPELYSAT-TWLGYVNSALNPVIYTTFNIEFRKA 393
           AF VCWLPFFL        C T C   P     T  WLGY NS +NP IY  FN + R  
Sbjct: 335 AFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTT 394

Query: 394 FLKILSC 400
           +  +L C
Sbjct: 395 YRSLLQC 401


>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
          Length = 479

 Score =  184 bits (466), Expect = 2e-46
 Identities = 129/367 (35%), Positives = 181/367 (49%), Gaps = 61/367 (16%)

Query: 39  LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
           + L  + GN LV ++V   + L+  +NYL+VSLA+ADL VA  VMP+V   ++ GG W F
Sbjct: 91  ITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIF 150

Query: 99  SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
               C+VF+ +DVM CTASI+ LC ISIDRY  +  P+ Y     + + + +A MI +VW
Sbjct: 151 GHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTY---PVRQNGKCMAKMILSVW 207

Query: 159 VLAFAVSCPLLFGF-NTTGDPTVCSISNP-DFVIYSSVVSFYLPFGVTVLVYARIYVVLK 216
           +L+ +++ P LFG+     D  VC IS    + IYS+ V+FY+P  V + +Y +IY   +
Sbjct: 208 LLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAAR 267

Query: 217 QRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGEL 276
           +   K              PGFP+  + PD                AL G          
Sbjct: 268 KSAAKHKF-----------PGFPR--VEPDSV-------------IALNG---------- 291

Query: 277 KREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLG 336
                           KL  EV + +N  LS  LK    +   +  RE+KA   + I++G
Sbjct: 292 --------------IVKLQKEVEECAN--LSRLLK-HERKNISIFKREQKAATTLGIIVG 334

Query: 337 AFIVCWLPFFLTHVLNTH-CQT-CHVSPELYSAT-TWLGYVNSALNPVIYTTFNIEFRKA 393
           AF VCWLPFFL        C T C   P     T  WLGY NS +NP IY  FN + R  
Sbjct: 335 AFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTT 394

Query: 394 FLKILSC 400
           +  +L C
Sbjct: 395 YRSLLQC 401


>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
          Length = 445

 Score =  184 bits (466), Expect = 2e-46
 Identities = 129/367 (35%), Positives = 181/367 (49%), Gaps = 61/367 (16%)

Query: 39  LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
           + L  + GN LV ++V   + L+  +NYL+VSLA+ADL VA  VMP+V   ++ GG W F
Sbjct: 91  ITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIF 150

Query: 99  SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
               C+VF+ +DVM CTASI+ LC ISIDRY  +  P+ Y     + + + +A MI +VW
Sbjct: 151 GHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTY---PVRQNGKCMAKMILSVW 207

Query: 159 VLAFAVSCPLLFGF-NTTGDPTVCSISNP-DFVIYSSVVSFYLPFGVTVLVYARIYVVLK 216
           +L+ +++ P LFG+     D  VC IS    + IYS+ V+FY+P  V + +Y +IY   +
Sbjct: 208 LLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAAR 267

Query: 217 QRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGEL 276
           +   K              PGFP+  + PD                AL G          
Sbjct: 268 KSAAKHKF-----------PGFPR--VEPDSV-------------IALNG---------- 291

Query: 277 KREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLG 336
                           KL  EV + +N  LS  LK    +   +  RE+KA   + I++G
Sbjct: 292 --------------IVKLQKEVEECAN--LSRLLK-HERKNISIFKREQKAATTLGIIVG 334

Query: 337 AFIVCWLPFFLTHVLNTH-CQT-CHVSPELYSAT-TWLGYVNSALNPVIYTTFNIEFRKA 393
           AF VCWLPFFL        C T C   P     T  WLGY NS +NP IY  FN + R  
Sbjct: 335 AFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTT 394

Query: 394 FLKILSC 400
           +  +L C
Sbjct: 395 YRSLLQC 401


>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
           sapiens]
          Length = 390

 Score =  182 bits (463), Expect = 4e-46
 Identities = 120/367 (32%), Positives = 182/367 (49%), Gaps = 48/367 (13%)

Query: 39  LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
           + LA    N  V   V + R L T  NYL+ SLAV DLLV+ LVMP      VTG  W  
Sbjct: 59  ITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGR-WTL 117

Query: 99  SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
            ++ CD +++ D+  CTASIL+LC I++DRY A+   V Y   + + + +R A+MI  VW
Sbjct: 118 GQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEY---SAKRTPKRAAVMIALVW 174

Query: 159 VLAFAVSCPLLFGFNTTGDPTVCS-ISNPD---FVIYSSVVSFYLPFGVTVLVYARIYVV 214
           V + ++S P  F      +  V   + N D   + +YS+V +FY P  + + +Y RIYV 
Sbjct: 175 VFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVE 234

Query: 215 LKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGG--PGFQER 272
            + R  K+   R   +          Q ++  P         S    T++    P     
Sbjct: 235 ARSRILKQTPNRTGKRLTRA------QLITDSPG--------STSSVTSINSRVPDVPSE 280

Query: 273 GGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVA 332
            G      + +  +S  +     LE +KL                  +  RE+KAT+ + 
Sbjct: 281 SGSPVYVNQVKVRVSDAL-----LEKKKL------------------MAARERKATKTLG 317

Query: 333 IVLGAFIVCWLPFFLTHVLNTHCQ-TCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFR 391
           I+LGAFIVCWLPFF+  ++   C+  C     ++   TWLGY+NS +NP+IYT  N +F+
Sbjct: 318 IILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFK 377

Query: 392 KAFLKIL 398
           +AF K++
Sbjct: 378 QAFHKLI 384


>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
           sapiens]
          Length = 366

 Score =  181 bits (460), Expect = 8e-46
 Identities = 119/373 (31%), Positives = 184/373 (49%), Gaps = 40/373 (10%)

Query: 33  ALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPW-VVYLEV 91
           +L+   L L     N LV  A++  R L    NYL+ SLAV D LVA LVMP+ +VY  +
Sbjct: 27  SLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVY--I 84

Query: 92  TGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVA 151
               W   ++ CD+++++D+  CT SIL+L AI++DRY A+   V Y     + + +   
Sbjct: 85  VRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYAR---KRTPKHAG 141

Query: 152 LMITAVWVLAFAVSCPLLF-GFNTTGDPTVCSISNPDFV--IYSSVVSFYLPFGVTVLVY 208
           +MIT VW+++  +S P LF     T     C I +   V  IYS+  +FY+P  + +++Y
Sbjct: 142 IMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILY 201

Query: 209 ARIYVVLKQRRRKRILTR-QNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGP 267
            +IY   K    KR  +R    + N        Q L             S   + +L  P
Sbjct: 202 YKIYRAAKTLYHKRQASRIAKEEVNG-------QVLLESGEKSTKSVSTSYVLEKSLSDP 254

Query: 268 GFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKA 327
                  +  +   T  SL      + S   +K+S                    RE+KA
Sbjct: 255 -----STDFDKIHSTVRSLRSEFKHEKSWRRQKISG------------------TRERKA 291

Query: 328 TQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFN 387
              + ++LGAF++CWLPFF+  ++   C  C +S E+ +   WLGY+NS +NP+IYT FN
Sbjct: 292 ATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFN 351

Query: 388 IEFRKAFLKILSC 400
            +F+KAF K++ C
Sbjct: 352 EDFKKAFQKLVRC 364


>gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo
           sapiens]
          Length = 458

 Score =  171 bits (434), Expect = 8e-43
 Identities = 116/379 (30%), Positives = 190/379 (50%), Gaps = 61/379 (16%)

Query: 33  ALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVT 92
           ALS   +I+  + GN LV MAV  E+ L   TNY ++SLA+AD+LV  LVMP  +   + 
Sbjct: 57  ALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILY 116

Query: 93  GGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVAL 152
             VW   R  C V+++LDV+  TASI++LCAIS+DRY A+  P+ +     ++   +  +
Sbjct: 117 DYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRT---KAIM 173

Query: 153 MITAVWVLAFAVSCPL-LFGFNTTG----DPTVCSISNPDFVIYSSVVSFYLPFGVTVLV 207
            I  VW ++  VS P+ + G         + T C +++P+FV+  S V+F++P  + V+ 
Sbjct: 174 KIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVIT 233

Query: 208 YARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGP 267
           Y     VL  RR+  +L   +++               +P  L L       ++TA    
Sbjct: 234 YCLTIYVL--RRQALMLLHGHTE---------------EPPGLSLDFLKCCKRNTA---- 272

Query: 268 GFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPL---RE 324
                      EE + N      A +   + R+                PRG       E
Sbjct: 273 ----------EEENSANPNQDQNARRRKKKERR----------------PRGTMQAINNE 306

Query: 325 KKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQ-TCH--VSPELYSATTWLGYVNSALNPV 381
           +KA++++ IV   F++ W PFF+T++L+  C+ +C+  +  +L +   W+GYV S +NP+
Sbjct: 307 RKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPL 366

Query: 382 IYTTFNIEFRKAFLKILSC 400
           +YT FN  +R+AF   L C
Sbjct: 367 VYTLFNKIYRRAFSNYLRC 385


>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
           sapiens]
          Length = 365

 Score =  166 bits (421), Expect = 3e-41
 Identities = 117/375 (31%), Positives = 185/375 (49%), Gaps = 74/375 (19%)

Query: 47  NGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPW-VVYLEVTGGVWNFSRICCDV 105
           N  V MA+   + L    NYL+ SLAV DLLVA LVMP  ++Y+ +    W      C+V
Sbjct: 40  NLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMDR--WKLGYFLCEV 97

Query: 106 FVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVS 165
           ++++D+  CT SIL+LC I++DRY A+   + Y     + + +R ALMI  VW ++  +S
Sbjct: 98  WLSVDMTCCTCSILHLCVIALDRYWAITNAIEYAR---KRTAKRAALMILTVWTISIFIS 154

Query: 166 CPLLFGFN---TTGDPTVCSISNPD--FVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRR 220
            P LF  +    +  P+ C+I +    + IYS++ +FY+P  + +++Y RIY   K   +
Sbjct: 155 MPPLFWRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQ 214

Query: 221 KRILTR---------QNS--QCNSVRPGFPQQTLSPDPAHLELKRYYSICQ----DTALG 265
           KR  +R         QNS   C   +        + DP   E +++++  +    D  L 
Sbjct: 215 KRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPT-TEFEKFHASIRIPPFDNDLD 273

Query: 266 GPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREK 325
            PG              R  +S T                                 RE+
Sbjct: 274 HPG-------------ERQQISST---------------------------------RER 287

Query: 326 KATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTT 385
           KA +++ ++LGAFI+ WLPFF+  ++        VS E+    TWLGYVNS +NP++YT+
Sbjct: 288 KAARILGLILGAFILSWLPFFIKELI-VGLSIYTVSSEVADFLTWLGYVNSLINPLLYTS 346

Query: 386 FNIEFRKAFLKILSC 400
           FN +F+ AF K++ C
Sbjct: 347 FNEDFKLAFKKLIRC 361


>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
          Length = 477

 Score =  165 bits (417), Expect = 8e-41
 Identities = 122/374 (32%), Positives = 182/374 (48%), Gaps = 60/374 (16%)

Query: 39  LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
           ++L IV GN LV +A+ K   LQT TN  ++SLA ADL++  LV+P+   + V  G W +
Sbjct: 68  IVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATI-VVWGRWEY 126

Query: 99  SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
               C+++ ++DV+  TASI  LC I++DRY A+  P  YQ    ++  R    ++  VW
Sbjct: 127 GSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARG---LVCTVW 183

Query: 159 VLAFAVS-CPLLFGF---------NTTGDPTVCS-ISNPDFVIYSSVVSFYLPFGVTVLV 207
            ++  VS  P+L  +             DP  C  ++N  + I SSVVSFY+P  +   V
Sbjct: 184 AISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFV 243

Query: 208 YARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGP 267
           Y R++   +++ +K     +       RP  P  +  P PA                  P
Sbjct: 244 YLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPA----------------PPP 287

Query: 268 GFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQP-RGVPLREKK 326
           G              R + +   AP        L+NGR       G  +P R V LRE+K
Sbjct: 288 G------------PPRPAAAAATAP--------LANGR------AGKRRPSRLVALREQK 321

Query: 327 ATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTF 386
           A + + I++G F +CWLPFFL +V+    +   V   L+    WLGY NSA NP+IY   
Sbjct: 322 ALKTLGIIMGVFTLCWLPFFLANVVKAFHREL-VPDRLFVFFNWLGYANSAFNPIIYCR- 379

Query: 387 NIEFRKAFLKILSC 400
           + +FRKAF  +L C
Sbjct: 380 SPDFRKAFQGLLCC 393


>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
          Length = 408

 Score =  155 bits (393), Expect = 5e-38
 Identities = 124/375 (33%), Positives = 174/375 (46%), Gaps = 78/375 (20%)

Query: 40  ILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFS 99
           +LA V GN LV +A+     LQT TN  V SLA ADL++  LV+P    L +TG  W   
Sbjct: 48  VLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGH-WPLG 106

Query: 100 RICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWV 159
              C+++ ++DV+  TASI  LCA+++DRY AV  P+ Y        C R A+++  VWV
Sbjct: 107 ATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRY-GALVTKRCARTAVVL--VWV 163

Query: 160 LAFAVS-CPLLFGFNTTG----------DPTVCSI-SNPDFVIYSSVVSFYLPFGVTVLV 207
           ++ AVS  P++  +   G          +P  C+  SN  +V+ SS VSFYLP  V + V
Sbjct: 164 VSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFV 223

Query: 208 YARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGP 267
           YAR++VV          TRQ          FP +   P P+                   
Sbjct: 224 YARVFVV---------ATRQLRLLRGELGRFPPEESPPAPS------------------- 255

Query: 268 GFQERGGELKREEKTRNSLSP----TIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLR 323
                            SL+P    T AP   +                G    R +PLR
Sbjct: 256 ----------------RSLAPAPVGTCAPPEGVPA-------------CGRRPARLLPLR 286

Query: 324 EKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIY 383
           E +A   + +++G F +CWLPFFL +VL        V    + A  WLGY NSA NP+IY
Sbjct: 287 EHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIY 346

Query: 384 TTFNIEFRKAFLKIL 398
              + +FR AF ++L
Sbjct: 347 CR-SPDFRSAFRRLL 360


>gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]
          Length = 357

 Score =  155 bits (393), Expect = 5e-38
 Identities = 109/365 (29%), Positives = 170/365 (46%), Gaps = 64/365 (17%)

Query: 39  LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
           L+ A    N LV   +L+ R      + LV S+AV+D+LVA LVMP  +  E++G  W  
Sbjct: 50  LVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQL 109

Query: 99  SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
            R  C +++  DV+ CTASI N+ AI++DRY ++   + Y   T +       +MI   W
Sbjct: 110 GRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSN---VMIALTW 166

Query: 159 VLAFAVS-CPLLFGFNTT--GDPTVCSIS-NPDFVIYSSVVSFYLPFGVTVLVYARIYVV 214
            L+  +S  PLLFG+  T       C +S  P + ++S+V +FYLP  V + VY +IY  
Sbjct: 167 ALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKA 226

Query: 215 LKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGG 274
            K     R+ +R+ +  + +      +  +  P  +   R+ ++          FQ   G
Sbjct: 227 AK----FRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVT---------FQPE-G 272

Query: 275 ELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIV 334
           +  RE+K                                          E++A  MV I+
Sbjct: 273 DTWREQK------------------------------------------EQRAALMVGIL 290

Query: 335 LGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAF 394
           +G F++CW+PFFLT +++  C +C +     S   WLGY NS  NP+IYT FN  +  AF
Sbjct: 291 IGVFVLCWIPFFLTELISPLC-SCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAF 349

Query: 395 LKILS 399
               S
Sbjct: 350 KNFFS 354


>gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo
           sapiens]
          Length = 481

 Score =  154 bits (388), Expect = 2e-37
 Identities = 108/378 (28%), Positives = 186/378 (49%), Gaps = 48/378 (12%)

Query: 33  ALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVT 92
           AL    +I+  + GN LV +AV  E+ LQ  TNY ++SLAVADLLV   VMP  +   + 
Sbjct: 58  ALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMF 117

Query: 93  GGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVA- 151
             +W    + C  ++ LDV+  TASI++LCAIS+DRY A+  P+       Q + R  A 
Sbjct: 118 EAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQ----ANQYNSRATAF 173

Query: 152 LMITAVWVLAFAVSCPL-LFGFNTTGD---PTVCSISNP---DFVIYSSVVSFYLPFGVT 204
           + IT VW+++  ++ P+ + G  T  D      C ++     DF+++ S+ +F+ P  + 
Sbjct: 174 IKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIM 233

Query: 205 VLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTAL 264
           ++ Y   ++ +   ++K  L +            P Q L+        +R      +T  
Sbjct: 234 IVTY---FLTIHALQKKAYLVKNK----------PPQRLTWLTVSTVFQR-----DETPC 275

Query: 265 GGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLRE 324
             P         ++++   NS   T+  + S  + K S   +S                E
Sbjct: 276 SSPEKVAMLDGSRKDKALPNSGDETLMRRTS-TIGKKSVQTIS---------------NE 319

Query: 325 KKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVS--PELYSATTWLGYVNSALNPVI 382
           ++A++++ IV   F++ W PFF+T++    C +C+ +    L     W+GYV+S +NP++
Sbjct: 320 QRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLV 379

Query: 383 YTTFNIEFRKAFLKILSC 400
           YT FN  FR AF + ++C
Sbjct: 380 YTLFNKTFRDAFGRYITC 397


>gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
           sapiens]
          Length = 440

 Score =  147 bits (371), Expect = 2e-35
 Identities = 115/394 (29%), Positives = 180/394 (45%), Gaps = 78/394 (19%)

Query: 19  NSTGASQARPHA------YYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLA 72
           NST A  A P +      + A + C +I      N L+   +  + AL+ T+N+ +VSL 
Sbjct: 10  NSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLF 69

Query: 73  VADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAV 132
            +DL+V  +VMP  + L    G W  +R  C ++   DVM C+ASILNLC IS+DRY  +
Sbjct: 70  TSDLMVGLVVMPPAM-LNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLI 128

Query: 133 VMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGD-----PTVCS-ISNP 186
           + P+ Y+     +  R +AL++ A  + A A   PLL G++  G      P  C  +++ 
Sbjct: 129 LSPLRYK--LRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASL 186

Query: 187 DFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPD 246
            FV+ +S ++F+LP G     Y RI +  +         +Q  Q  S+  G   Q     
Sbjct: 187 PFVLVASGLTFFLPSGAICFTYCRILLAAR---------KQAVQVASLTTGMASQASET- 236

Query: 247 PAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRL 306
              L++ R            PG +                        S + R+L+    
Sbjct: 237 ---LQVPR---------TPRPGVE------------------------SADSRRLATKHS 260

Query: 307 STSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYS 366
             +LK               A+  + I+LG F V WLPFF+ +++   C    +SP L+ 
Sbjct: 261 RKALK---------------ASLTLGILLGMFFVTWLPFFVANIVQAVCDC--ISPGLFD 303

Query: 367 ATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 400
             TWLGY NS +NP+IY  F  +F++A  + L C
Sbjct: 304 VLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPC 337


>gi|194018562 histamine receptor H3 [Homo sapiens]
          Length = 445

 Score =  137 bits (345), Expect = 2e-32
 Identities = 118/431 (27%), Positives = 185/431 (42%), Gaps = 56/431 (12%)

Query: 8   SGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYL 67
           SG L     A        A   A  A     LI+A V GN LV +A + + +L+T  N+ 
Sbjct: 13  SGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFF 72

Query: 68  VVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISID 127
           +++LA++D LV    +P  V   +TG  W F R  C +++ +D ++CT+S  N+  IS D
Sbjct: 73  LLNLAISDFLVGAFCIPLYVPYVLTGR-WTFGRGLCKLWLVVDYLLCTSSAFNIVLISYD 131

Query: 128 RYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFN-TTGDPTVCS---- 182
           R+ +V   V Y+    Q   RR    +  VWVLAF +  P +  +   +G  ++      
Sbjct: 132 RFLSVTRAVSYR--AQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCY 189

Query: 183 ---ISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFP 239
                N  F+I +S + F+ PF         IY+ +++R R R L           P   
Sbjct: 190 AEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLR-LDGAREAAGPEPPPEA 248

Query: 240 QQTLSPDPA-----------HLELKRY-------YSICQDTALGG-------------PG 268
           Q +  P P             + L RY        +   +  LGG              G
Sbjct: 249 QPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSG 308

Query: 269 FQERGGELKREEKTRNSLSPTIAPKLSLEVR-KLSNGRLSTSLKLGPLQPRGVPLREKKA 327
              RG E  R  K  +  S   A   SLE R K+ +   +   +L          R++K 
Sbjct: 309 SSSRGTERPRSLKRGSKPS---ASSASLEKRMKMVSQSFTQRFRLS---------RDRKV 356

Query: 328 TQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFN 387
            + +A+++  F +CW P+ L  ++   C    V    Y  + WL + NSA+NPV+Y   +
Sbjct: 357 AKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCH 416

Query: 388 IEFRKAFLKIL 398
             FR+AF K+L
Sbjct: 417 HSFRRAFTKLL 427


>gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens]
          Length = 479

 Score =  137 bits (344), Expect = 2e-32
 Identities = 120/437 (27%), Positives = 188/437 (43%), Gaps = 81/437 (18%)

Query: 38  ALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMP-WVVYLEVTGGVW 96
           +L L  V GN LV +++   R LQT  NY + SLA ADL++    M  + VY  +  G W
Sbjct: 41  SLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVY--IIKGYW 98

Query: 97  NFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITA 156
               + CD+++ LD ++  AS++NL  IS DRY  V  P+ Y     + + +   LMI A
Sbjct: 99  PLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTY---PARRTTKMAGLMIAA 155

Query: 157 VWVLAFAVSCP-LLFGFNTTGDPTV----CSI---SNPDFVIYSSVVSFYLPFGVTVLVY 208
            WVL+F +  P +LF     G  TV    C I   SNP     +++ +FYLP  +  ++Y
Sbjct: 156 AWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLY 215

Query: 209 ARIYVVLKQRRRKR-------------ILTRQNSQCNSVR---PG--------------F 238
             I +  + R  K                 +      SV+   PG               
Sbjct: 216 IHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEA 275

Query: 239 PQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSL-SPTIAP----- 292
           P   L P P  +  K   +     +      +    EL   E T  ++ +P + P     
Sbjct: 276 PPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNP 335

Query: 293 -----KLSLEVRKLSNGRLSTSLKLGPLQPRGV----------------PLREK------ 325
                K+ + V K +     T++++ P  P G+                 +R+K      
Sbjct: 336 ASRWSKIQI-VTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAAR 394

Query: 326 --KATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIY 383
             K T+ +  +L AFI+ W P+ +  ++NT CQ+C +   ++S   WL YVNS +NP  Y
Sbjct: 395 ERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSC-IPDTVWSIGYWLCYVNSTINPACY 453

Query: 384 TTFNIEFRKAFLKILSC 400
              N  F+K F  +L C
Sbjct: 454 ALCNATFKKTFRHLLLC 470


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.137    0.424 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,930,443
Number of Sequences: 37866
Number of extensions: 667821
Number of successful extensions: 3771
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 357
Number of HSP's successfully gapped in prelim test: 268
Number of HSP's that attempted gapping in prelim test: 2269
Number of HSP's gapped (non-prelim): 1138
length of query: 400
length of database: 18,247,518
effective HSP length: 104
effective length of query: 296
effective length of database: 14,309,454
effective search space: 4235598384
effective search space used: 4235598384
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.