Search of human proteins with 7657359

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7657359 contactin 5 isoform long [Homo sapiens]
         (1100 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7657359 contactin 5 isoform long [Homo sapiens]                   2208   0.0  
gi|28373129 contactin 5 isoform short [Homo sapiens]                 2029   0.0  
gi|28373122 contactin 4 isoform a precursor [Homo sapiens]           1154   0.0  
gi|75709184 contactin 3 [Homo sapiens]                               1130   0.0  
gi|7657361 contactin 6 [Homo sapiens]                                1041   0.0  
gi|4827022 contactin 2 precursor [Homo sapiens]                       898   0.0  
gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens]            894   0.0  
gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens]            894   0.0  
gi|28373126 contactin 4 isoform c precursor [Homo sapiens]            734   0.0  
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo...   404   e-112
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ...   404   e-112
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s...   404   e-112
gi|237858679 neurofascin isoform 3 precursor [Homo sapiens]           368   e-101
gi|89903008 neurofascin isoform 4 precursor [Homo sapiens]            368   e-101
gi|81158224 neuronal cell adhesion molecule isoform B precursor ...   362   1e-99
gi|237858677 neurofascin isoform 2 precursor [Homo sapiens]           360   5e-99
gi|81158226 neuronal cell adhesion molecule isoform A precursor ...   358   2e-98
gi|27894376 cell adhesion molecule with homology to L1CAM precur...   348   2e-95
gi|237858675 neurofascin isoform 1 precursor [Homo sapiens]           346   6e-95
gi|222352127 sidekick 2 [Homo sapiens]                                274   3e-73
gi|119220552 sidekick 1 [Homo sapiens]                                274   4e-73
gi|28373124 contactin 4 isoform b precursor [Homo sapiens]            249   1e-65
gi|237858682 neurofascin isoform 6 precursor [Homo sapiens]           244   3e-64
gi|237858680 neurofascin isoform 5 precursor [Homo sapiens]           244   3e-64
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42...   239   1e-62
gi|19743806 roundabout 1 isoform b [Homo sapiens]                     219   1e-56
gi|4506569 roundabout 1 isoform a [Homo sapiens]                      219   1e-56
gi|224994173 roundabout 1 isoform d [Homo sapiens]                    214   4e-55
gi|224994171 roundabout 1 isoform c [Homo sapiens]                    214   4e-55
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ...   214   4e-55

>gi|7657359 contactin 5 isoform long [Homo sapiens]
          Length = 1100

 Score = 2208 bits (5721), Expect = 0.0
 Identities = 1100/1100 (100%), Positives = 1100/1100 (100%)

Query: 1    MASSWKLMLFLSVTMCLSEYSKSLPGLSTSYAALLRIKKSSSSSLFGSKTRPRYSSPSLG 60
            MASSWKLMLFLSVTMCLSEYSKSLPGLSTSYAALLRIKKSSSSSLFGSKTRPRYSSPSLG
Sbjct: 1    MASSWKLMLFLSVTMCLSEYSKSLPGLSTSYAALLRIKKSSSSSLFGSKTRPRYSSPSLG 60

Query: 61   TLSASSPSWLGAAQNYYSPINLYHSSDAFKQDESVDYGPVFVQEPDDIIFPTDSDEKKVA 120
            TLSASSPSWLGAAQNYYSPINLYHSSDAFKQDESVDYGPVFVQEPDDIIFPTDSDEKKVA
Sbjct: 61   TLSASSPSWLGAAQNYYSPINLYHSSDAFKQDESVDYGPVFVQEPDDIIFPTDSDEKKVA 120

Query: 121  LNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVG 180
            LNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVG
Sbjct: 121  LNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVG 180

Query: 181  SILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVA 240
            SILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVA
Sbjct: 181  SILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVA 240

Query: 241  EDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEP 300
            EDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEP
Sbjct: 241  EDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEP 300

Query: 301  KIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQ 360
            KIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQ
Sbjct: 301  KIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQ 360

Query: 361  LDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPT 420
            LDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPT
Sbjct: 361  LDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPT 420

Query: 421  YRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAP 480
            YRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAP
Sbjct: 421  YRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAP 480

Query: 481  TFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILN 540
            TFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILN
Sbjct: 481  TFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILN 540

Query: 541  ASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDAS 600
            ASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDAS
Sbjct: 541  ASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDAS 600

Query: 601  LDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVS 660
            LDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVS
Sbjct: 601  LDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVS 660

Query: 661  DEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVK 720
            DEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVK
Sbjct: 661  DEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVK 720

Query: 721  TVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNV 780
            TVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNV
Sbjct: 721  TVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNV 780

Query: 781  SGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDES 840
            SGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDES
Sbjct: 781  SGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDES 840

Query: 841  VPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIK 900
            VPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIK
Sbjct: 841  VPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIK 900

Query: 901  ESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGP 960
            ESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGP
Sbjct: 901  ESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGP 960

Query: 961  PSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSN 1020
            PSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSN
Sbjct: 961  PSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSN 1020

Query: 1021 SQVIETQKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQIRVPSYSGGKITSAQSTLHSL 1080
            SQVIETQKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQIRVPSYSGGKITSAQSTLHSL
Sbjct: 1021 SQVIETQKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQIRVPSYSGGKITSAQSTLHSL 1080

Query: 1081 STSSSSVTLLLALMIPSTSW 1100
            STSSSSVTLLLALMIPSTSW
Sbjct: 1081 STSSSSVTLLLALMIPSTSW 1100


>gi|28373129 contactin 5 isoform short [Homo sapiens]
          Length = 1026

 Score = 2029 bits (5256), Expect = 0.0
 Identities = 1008/1008 (100%), Positives = 1008/1008 (100%)

Query: 93   ESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSL 152
            ESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSL
Sbjct: 19   ESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSL 78

Query: 153  IDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQG 212
            IDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQG
Sbjct: 79   IDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQG 138

Query: 213  VVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVK 272
            VVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVK
Sbjct: 139  VVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVK 198

Query: 273  NTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTI 332
            NTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTI
Sbjct: 199  NTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTI 258

Query: 333  TWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHW 392
            TWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHW
Sbjct: 259  TWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHW 318

Query: 393  VEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSD 452
            VEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSD
Sbjct: 319  VEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSD 378

Query: 453  AGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPT 512
            AGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPT
Sbjct: 379  AGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPT 438

Query: 513  ISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPT 572
            ISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPT
Sbjct: 439  ISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPT 498

Query: 573  RIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASS 632
            RIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASS
Sbjct: 499  RIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASS 558

Query: 633  ADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWS 692
            ADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWS
Sbjct: 559  ADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWS 618

Query: 693  PAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATN 752
            PAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATN
Sbjct: 619  PAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATN 678

Query: 753  PIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVA 812
            PIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVA
Sbjct: 679  PIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVA 738

Query: 813  FRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAE 872
            FRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAE
Sbjct: 739  FRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAE 798

Query: 873  GEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNE 932
            GEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNE
Sbjct: 799  GEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNE 858

Query: 933  SFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSL 992
            SFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSL
Sbjct: 859  SFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSL 918

Query: 993  GWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEVRAYSEGG 1052
            GWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEVRAYSEGG
Sbjct: 919  GWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEVRAYSEGG 978

Query: 1053 DGTASSQIRVPSYSGGKITSAQSTLHSLSTSSSSVTLLLALMIPSTSW 1100
            DGTASSQIRVPSYSGGKITSAQSTLHSLSTSSSSVTLLLALMIPSTSW
Sbjct: 979  DGTASSQIRVPSYSGGKITSAQSTLHSLSTSSSSVTLLLALMIPSTSW 1026



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 19/19 (100%), Positives = 19/19 (100%)

Query: 1  MASSWKLMLFLSVTMCLSE 19
          MASSWKLMLFLSVTMCLSE
Sbjct: 1  MASSWKLMLFLSVTMCLSE 19


>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
          Length = 1026

 Score = 1154 bits (2986), Expect = 0.0
 Identities = 556/1005 (55%), Positives = 720/1005 (71%), Gaps = 10/1005 (0%)

Query: 92   DESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYS 151
            D+S  +GP+F+QEP  ++FP DS+EKKV LNCEV+GNP P  RW  NGT++D   D+RYS
Sbjct: 19   DDSTLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYS 78

Query: 152  LIDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQ 211
            +++G+ +I+NP++ +D+G YQC ATN+ G+I+SREA LQFAYL NF  RTRS VSVR GQ
Sbjct: 79   VVEGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQ 138

Query: 212  GVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLV 271
            G+VL+C PPPHS E+ Y+W+FNE+PS+  +D+RRF+SQETGNLYI+KV+ SDVG+Y C+V
Sbjct: 139  GMVLLCGPPPHSGELSYAWIFNEYPSY--QDNRRFVSQETGNLYIAKVEKSDVGNYTCVV 196

Query: 272  KNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPT 331
             NTVTN +VL PPTPL LRNDGVMGEYEPKIEV FP TV  AKG TVK+ECFALGNPVPT
Sbjct: 197  TNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPT 256

Query: 332  ITWMKVNGY-IPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYP 390
            I W + +G  I  KAR  KS  +LEIPN Q +DAG+YEC AENSRGKN  RGQL  Y  P
Sbjct: 257  IIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQP 316

Query: 391  HWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQ 450
            +W++K+ND  +     + WECKA G+P+PTY+WLKNG PL  + R+++  G L I  VN 
Sbjct: 317  NWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNL 376

Query: 451  SDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPK 510
            SDAGMYQCLAENK+G I+++AEL ++A  P F+   LK+  +V    EVVIECKP+ SPK
Sbjct: 377  SDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPK 436

Query: 511  PTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKE 570
            P  +WKKG   ++EN+RI I  DG+LRI+N +KSD G Y C   N FG+A    +L VK+
Sbjct: 437  PVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKD 496

Query: 571  PTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQA 630
            PTR+ + P   ++TVGESIVL C+  HD SLD+ F W+  G  IDF+ +G HFE +  Q 
Sbjct: 497  PTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQD 556

Query: 631  SSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLS 690
            S+ DLMIRNI L HAG+Y C VQT+ D +S  A+L+VRGPPGPP  V ++EIT++TA LS
Sbjct: 557  SAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLS 616

Query: 691  WSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVA 750
            W P  DNHSPI+ Y +QAR+PFS+GWQ V TVPE+I G   +A  V LNPWVEYEFR VA
Sbjct: 617  WRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVA 676

Query: 751  TNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYI 810
             N IG G+PS PS   RT EA+P+  P NVSG  G + ELVI WE V EE QNG GFGY+
Sbjct: 677  ANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYV 736

Query: 811  VAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICS 870
            VAFRP G   W   ++ S++AS++++R+ESV P +PFEVKVGV+NNKG+GPFS   V+ S
Sbjct: 737  VAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYS 796

Query: 871  AEGEPSAAPTDVKATSVSVSEILVAW-KHIKESLGRPQGFEVGYWKDMEQEDTAETVKTR 929
            AE EP+  P  + A S+S ++I V W   ++++ GR QG+EV YW+  ++E+ A  ++T 
Sbjct: 797  AEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTV 856

Query: 930  GNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQ 989
            GN++   +T L+G+ LYH  V+AYN AG GP S+ V+ TT+K PPSQ P N+ W    S+
Sbjct: 857  GNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSK 916

Query: 990  VSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEVRAYS 1049
            + L W+ V  L NESEV GYKV YR    S++ VIET K    + LP    YIIE++ +S
Sbjct: 917  IILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFS 976

Query: 1050 EGGDGTASSQIRVPSYS------GGKITSAQSTLHSLSTSSSSVT 1088
            +GGDG++S QIR+P  S       G  TS   TL ++ST   S+T
Sbjct: 977  DGGDGSSSEQIRIPKISNAYARGSGASTSNACTLSAISTIMISLT 1021


>gi|75709184 contactin 3 [Homo sapiens]
          Length = 1028

 Score = 1130 bits (2924), Expect = 0.0
 Identities = 551/1004 (54%), Positives = 714/1004 (71%), Gaps = 7/1004 (0%)

Query: 98   GPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTF 157
            GPVF++EP + IFP  S++KK+ L+CE RGNP P YRW  NG++ID+  ++RY L  G  
Sbjct: 25   GPVFIKEPSNSIFPVGSEDKKITLHCEARGNPSPHYRWQLNGSDIDMSMEHRYKLNGGNL 84

Query: 158  IISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMC 217
            ++ NP+   D+G YQC ATN++G+I+SREA LQFAYL NF  + RS VSVREGQGVVL+C
Sbjct: 85   VVINPNRNWDTGTYQCFATNSLGTIVSREAKLQFAYLENFKTKMRSTVSVREGQGVVLLC 144

Query: 218  SPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTN 277
             PPPHS E+ Y+W+FNE+PSFV EDSRRF+SQETG+LYISKV+ SDVG+Y C+V + VTN
Sbjct: 145  GPPPHSGELSYAWIFNEYPSFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCVVTSMVTN 204

Query: 278  ARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKV 337
            ARVL  PTPL LR+DGVMGEYEPKIEV FP T+ AAKG+TVK+ECFALGNP+P I W + 
Sbjct: 205  ARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQINWRRS 264

Query: 338  NGY-IPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKL 396
            +G    SK +LRK   VLEIPN Q +DAG YEC AENSRGKN  RG+L  Y  PHWV+ +
Sbjct: 265  DGLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRGKNVARGRLTYYAKPHWVQLI 324

Query: 397  NDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMY 456
             D ++     L WEC+A+GKP+P+YRWLKNG  L  + R ++ NG L I N++ +D+GM+
Sbjct: 325  KDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVLEERTQIENGALTISNLSVTDSGMF 384

Query: 457  QCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWK 516
            QC+AENK+G +Y+SAELK++ASAP F+ N +KK + V     V ++CKP+ SP+   SWK
Sbjct: 385  QCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKPRASPRALSSWK 444

Query: 517  KGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIEL 576
            KGD +V+E++RI++L DG L+I N +K+D G Y C  EN FG A     L V EPTRI L
Sbjct: 445  KGDVSVQEHERISLLNDGGLKIANVTKADAGTYTCMAENQFGKANGTTHLVVTEPTRITL 504

Query: 577  TPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLM 636
             P   +++VGES++L C+  HD  LD+ F W   G   DF+++G HFE +   +SS DLM
Sbjct: 505  APSNMDVSVGESVILPCQVQHDPLLDIIFTWYFNGALADFKKDGSHFEKVGG-SSSGDLM 563

Query: 637  IRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAAD 696
            IRNI L H+G+Y C VQT  DSVS  A+L+VRG PGPP  V V+EIT++TA LSW    D
Sbjct: 564  IRNIQLKHSGKYVCMVQTGVDSVSSAADLIVRGSPGPPENVKVDEITDTTAQLSWKEGKD 623

Query: 697  NHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGT 756
            NHSP+ SY++QAR+PFS+GWQTV TVPE+I G   +A  V+LNPWVEYEFRVVA+N IG 
Sbjct: 624  NHSPVISYSIQARTPFSVGWQTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGG 683

Query: 757  GDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPN 816
            G+PS PS  +RT EAVP+  P+ V+G  G R ELVI W+PV EE QNGEGFGY+VAFRP 
Sbjct: 684  GEPSLPSEKVRTEEAVPEVPPSEVNGGGGSRSELVITWDPVPEELQNGEGFGYVVAFRPL 743

Query: 817  GTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPS 876
            G   W + +VTS +  ++++R+ES+ P +P+EVKVGVYNNKG+GPFS +  + SAE EP+
Sbjct: 744  GVTTWIQTVVTSPDTPRYVFRNESIVPYSPYEVKVGVYNNKGEGPFSPVTTVFSAEEEPT 803

Query: 877  AAPTDVKATSVSVSEILVAWKHI--KESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESF 934
             AP+ V A S+S SEI V+W  I  K S G   G+EV YW    +E+++  +K  GNE+ 
Sbjct: 804  VAPSQVSANSLSSSEIEVSWNTIPWKLSNGHLLGYEVRYWNGGGKEESSSKMKVAGNETS 863

Query: 935  VILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGW 994
              L GL+ N  Y+  VRAYN AG GP S+ V+ TTKK+PPSQ P N+ W    ++V L W
Sbjct: 864  ARLRGLKSNLAYYTAVRAYNSAGAGPFSATVNVTTKKTPPSQPPGNVVWNATDTKVLLNW 923

Query: 995  EPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEVRAYSEGGDG 1054
            E V  + NESEV GYKVFYR    +N QV+ T K  A + LP    YIIEV+A ++GGDG
Sbjct: 924  EQVKAMENESEVTGYKVFYRTSSQNNVQVLNTNKTSAELVLPIKEDYIIEVKATTDGGDG 983

Query: 1055 TASSQIRVP---SYSGGKITSAQSTLHSLSTSSSSVTLLLALMI 1095
            T+S QIR+P   S      TSA S +H +S+    V  L+  ++
Sbjct: 984  TSSEQIRIPRITSMDARGSTSAISNVHPMSSYMPIVLFLIVYVL 1027


>gi|7657361 contactin 6 [Homo sapiens]
          Length = 1028

 Score = 1041 bits (2691), Expect = 0.0
 Identities = 511/989 (51%), Positives = 671/989 (67%), Gaps = 7/989 (0%)

Query: 99   PVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFI 158
            P+F QEP D+IFP D  + +V LNC   G P P YRW +NGT+ID    Y Y L  G+  
Sbjct: 26   PIFTQEPHDVIFPLDLSKSEVILNCAANGYPSPHYRWKQNGTDIDFTMSYHYRLDGGSLA 85

Query: 159  ISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCS 218
            I++P   +D G YQCLATN +G+ILSR+A LQFAY+ +F  +TRS VSVREGQGVVL+C 
Sbjct: 86   INSPHTDQDIGMYQCLATNLLGTILSRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLCG 145

Query: 219  PPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNA 278
            PPPH  ++ Y+W FN+ P +V ED+RRF+SQETGNLYI+KV+ SDVG+Y C + N     
Sbjct: 146  PPPHFGDLSYAWTFNDNPLYVQEDNRRFVSQETGNLYIAKVEPSDVGNYTCFITNKEAQR 205

Query: 279  RVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVN 338
             V  PPTPL  R DGVMGEYEPKIEV FP T+ AAK ++VK+ECFALGNPVP I+W +++
Sbjct: 206  SVQGPPTPLVQRTDGVMGEYEPKIEVRFPETIQAAKDSSVKLECFALGNPVPDISWRRLD 265

Query: 339  GY-IPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLN 397
            G  +P K +  KSQA+LEIPN Q +D G YEC A N RG+N  +GQL  Y  P W +K+ 
Sbjct: 266  GSPLPGKVKYSKSQAILEIPNFQQEDEGFYECIASNLRGRNLAKGQLIFYAPPEWEQKIQ 325

Query: 398  DTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQ 457
            +T L     L WECKA+GKP P Y WLKNG  L+P+ R+++ NG L+I  +N SD+G+YQ
Sbjct: 326  NTHLSIYDNLLWECKASGKPNPWYTWLKNGERLNPEERIQIENGTLIITMLNVSDSGVYQ 385

Query: 458  CLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKK 517
            C AENKY  IYA+AEL++LASAP F+ + +KK   V    ++VI CKP   P+  ISWK+
Sbjct: 386  CAAENKYQIIYANAELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISWKR 445

Query: 518  GDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELT 577
            G   +R++KRI +L DGSL+I N ++SD G Y C   N FG+A+   SL VKE T I + 
Sbjct: 446  GTETLRQSKRIFLLEDGSLKIYNITRSDAGSYTCIATNQFGTAKNTGSLIVKERTVITVP 505

Query: 578  PKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMI 637
            P + ++TVGESIVL C+  HD S++V F W   G  ID ++   HFE I  + S  DLMI
Sbjct: 506  PSKMDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGE-SVGDLMI 564

Query: 638  RNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADN 697
            RNI L H+G+Y C VQTT +S+S  A+++VRGPPGPP  V VE+I+ +T+ LSW    DN
Sbjct: 565  RNIQLHHSGKYLCTVQTTLESLSAVADIIVRGPPGPPEDVQVEDISSTTSQLSWRAGPDN 624

Query: 698  HSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTG 757
            +SPI  + +Q R+PFS+GWQ V TVPEI+ G   +A  V L+PWVEYEFRVVA N IG G
Sbjct: 625  NSPIQIFTIQTRTPFSVGWQAVATVPEILNGKTYNATVVGLSPWVEYEFRVVAGNSIGIG 684

Query: 758  DPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNG 817
            +PS PS ++RT  +VP  AP N+ G  G R ELVI WE + EE QNGEGFGYI+ FRP G
Sbjct: 685  EPSEPSELLRTKASVPVVAPVNIHGGGGSRSELVITWESIPEELQNGEGFGYIIMFRPVG 744

Query: 818  TRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSA 877
            +  W ++ V+S E+S+F+YR+ES+ PL+PFEVKVGVYNN+G+G  S + ++ S E EP  
Sbjct: 745  STTWSKEKVSSVESSRFVYRNESIIPLSPFEVKVGVYNNEGEGSLSTVTIVYSGEDEPQL 804

Query: 878  APTDVKATSVSVSEILVAWKHI--KESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFV 935
            AP      S S SE+ V+W  I    + GR  G+EV YW D  +E     ++  GN +  
Sbjct: 805  APRGTSLQSFSASEMEVSWNAIAWNRNTGRVLGYEVLYWTDDSKESMIGKIRVSGNVTTK 864

Query: 936  ILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWE 995
             +TGL+ NT+Y  +VRAYN AG GP S  V+ TTKKSPPSQ P+N+ W+   S++ L WE
Sbjct: 865  NITGLKANTIYFASVRAYNTAGTGPSSPPVNVTTKKSPPSQPPANIAWKLTNSKLCLNWE 924

Query: 996  PVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEVRAYSEGGDGT 1055
             V  + NESEV+GYK+ YRQ   S + ++ET    A + +P    Y+IE+R  S+GGDG+
Sbjct: 925  HVKTMENESEVLGYKILYRQNRQSKTHILETNNTSAELLVPFEEDYLIEIRTVSDGGDGS 984

Query: 1056 ASSQIRVP---SYSGGKITSAQSTLHSLS 1081
            +S +IR+P   S S   I   + + H LS
Sbjct: 985  SSEEIRIPKMSSLSSRGIQFLEPSTHFLS 1013


>gi|4827022 contactin 2 precursor [Homo sapiens]
          Length = 1040

 Score =  898 bits (2321), Expect = 0.0
 Identities = 435/962 (45%), Positives = 613/962 (63%), Gaps = 7/962 (0%)

Query: 97   YGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGT 156
            +GPVF  +P  ++FP +S E++V L C  R +P  +YRW  NGTE+ LE   R+ L+ G 
Sbjct: 35   FGPVFEDQPLSVLFPEESTEEQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGN 94

Query: 157  FIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLM 216
             +I NP++A+D+G YQCLA+N VG+++SREA L+F +L  FS   R  V   EG GV+L 
Sbjct: 95   LVIMNPTKAQDAGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLP 154

Query: 217  CSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTV- 275
            C+PP H P + Y W+ NEFP+F+  D R F+SQ TGNLYI++   SD+G+Y CL  + + 
Sbjct: 155  CNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMD 214

Query: 276  -TNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITW 334
             +   V S    L L  +     + P I+  FP    A  G  V +ECFA GNPVP I W
Sbjct: 215  FSTKSVFSKFAQLNLAAEDTR-LFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKW 273

Query: 335  MKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVE 394
             KV+G +    +   ++  L+IP+V  +D G YEC AENS+G+++ +G++ V   P W++
Sbjct: 274  RKVDGSL--SPQWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQPEWLK 331

Query: 395  KLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAG 454
             ++DT+ D GS LRW C A GKPRPT RWL+NG PL+ Q+RVE++ G L    ++  D+G
Sbjct: 332  VISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLAGDLRFSKLSLEDSG 391

Query: 455  MYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTIS 514
            MYQC+AENK+G IYASAEL + A AP F LN +++ I   +  E++I C+P+ +PK  + 
Sbjct: 392  MYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVL 451

Query: 515  WKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRI 574
            W KG   +  + R+ + PDG+L I N S+SDEGKY C  EN  G A     LSV++ T+I
Sbjct: 452  WSKGTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKI 511

Query: 575  ELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSAD 634
             L P   ++ +G+++ L C A HD ++D+TF WTL   PIDF++ GGH+     + +  D
Sbjct: 512  TLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGD 571

Query: 635  LMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPA 694
            L I N  L H G+Y C  QT  DS S EA +LVRGPPGPPG V+V +I ++T  LSWS  
Sbjct: 572  LTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSWSRG 631

Query: 695  ADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPI 754
             DNHSPI+ Y LQAR+P +  W+ V+T P  I G+ E+A  + L PW++YEFRV+A+N +
Sbjct: 632  FDNHSPIAKYTLQARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNIL 691

Query: 755  GTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFR 814
            GTG+PS PS  IRT EA P  AP+ +SG  G   EL++ W P+S E+QNG+GFGY+++FR
Sbjct: 692  GTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQNGDGFGYLLSFR 751

Query: 815  PNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGE 874
              G+  W+   V  ++A  F+Y +ESV P TPFEVK+  YN +GDGP S   ++ SAE E
Sbjct: 752  RQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEE 811

Query: 875  PSAAPTDVKATSVSVSEILVAWKHIKESL-GRPQGFEVGYWKDMEQEDTAETVKTRGNES 933
            P  APT V A  VS SE+ V W+ +++ + G   G+E+ YWK  ++E  A+ V+T G ++
Sbjct: 812  PRVAPTKVWAKGVSSSEMNVTWEPVQQDMNGILLGYEIRYWKAGDKEAAADRVRTAGLDT 871

Query: 934  FVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLG 993
               ++GL  NT YH TVRAYN AG GP S   +ATT K PP + P N+ W    S +S+ 
Sbjct: 872  SARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNISWTFSSSSLSIK 931

Query: 994  WEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLP-DAGVYIIEVRAYSEGG 1052
            W+PV+P  NES V GYK+ Y+ + H    +  T K    +P+P D G  ++++R    GG
Sbjct: 932  WDPVVPFRNESAVTGYKMLYQNDLHLTPTLHLTGKNWIEIPVPEDIGHALVQIRTTGPGG 991

Query: 1053 DG 1054
            DG
Sbjct: 992  DG 993



 Score =  110 bits (276), Expect = 6e-24
 Identities = 211/908 (23%), Positives = 325/908 (35%), Gaps = 128/908 (14%)

Query: 214  VLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYI-SKVQTSDVGSYICLVK 272
            VL+      SP   Y W  N     +   SR  +    GNL I +  +  D G Y CL  
Sbjct: 57   VLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVG--GNLVIMNPTKAQDAGVYQCLAS 114

Query: 273  NTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGN-PVPT 331
            N V    V+S    L     G + E+    E   P  V A +G  V + C    + P  +
Sbjct: 115  NPV--GTVVSREAILRF---GFLQEFSK--EERDP--VKAHEGWGVMLPCNPPAHYPGLS 165

Query: 332  ITWM--KVNGYIPSKARLRKSQAV--LEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVY 387
              W+  +   +IP+  R   SQ    L I      D G Y C A +      F  +    
Sbjct: 166  YRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHM---DFSTKSVFS 222

Query: 388  TYPHWVEKLNDTQLDS---------------GSPLRWECKATGKPRPTYRWLKNGVPLSP 432
             +        DT+L +               G  +  EC A G P P  +W K    LSP
Sbjct: 223  KFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSP 282

Query: 433  QSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTII 492
            Q         L I +V+  D G Y+C AEN  G       + + A           + + 
Sbjct: 283  QWTT--AEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQP---------EWLK 331

Query: 493  VTKDQEVVIE------CKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDE 546
            V  D E  I       C   G P+PT+ W +    +    R+ +L  G LR    S  D 
Sbjct: 332  VISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLA-GDLRFSKLSLEDS 390

Query: 547  GKYVCRGENVFGSAEIIASLSVKE-PTRIELTPKRTELTV--GESIVLNCKAIHDASLDV 603
            G Y C  EN  G+    A L+V+       L P R  +    G  I++ C+    A+   
Sbjct: 391  GMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQP--RAAPKA 448

Query: 604  TFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEA 663
               W+ KG  I          S         L+IRNI     G+Y C  +      +   
Sbjct: 449  VVLWS-KGTEILVNS------SRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTG 501

Query: 664  ELLVRGP------PGPPGIVIVEEIT-------ESTATLSWSPAADNHSPIS-----SYN 705
             L VR        P    I + + +T       + T  L+++   D+  PI       + 
Sbjct: 502  ILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDF-PIDFDKPGGHY 560

Query: 706  LQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRM 765
             +     ++G  T+    ++  G   + MA  +      E  V+   P G          
Sbjct: 561  RRTNVKETIGDLTILNA-QLRHGGKYTCMAQTVVDSASKEATVLVRGPPGP--------- 610

Query: 766  IRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFG-YIVAFRPNGTRGWKEK 824
                       P  V  R      + ++W   S  F N      Y +  R      WK+ 
Sbjct: 611  -----------PGGVVVRDIGDTTIQLSW---SRGFDNHSPIAKYTLQARTPPAGKWKQV 656

Query: 825  MVTSS--EASKFIYRDESVPPLTPFEVKVGVYNNKGDG-PFSQIVVICSAEGEPSAAPTD 881
                +  E +    +   + P   +E +V   N  G G P      I + E  PS AP+ 
Sbjct: 657  RTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSG 716

Query: 882  VKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTA--ETVKTRGNESFVILTG 939
            +     +  E++V W  +        GF  GY     ++ +   +T +  G ++   +  
Sbjct: 717  LSGGGGAPGELIVNWTPMSREYQNGDGF--GYLLSFRRQGSTHWQTARVPGADAQYFVYS 774

Query: 940  LEG---NTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQ--QGSQVSLGW 994
             E     T +   +R+YN  G GP S      + +  P  AP+ + W +    S++++ W
Sbjct: 775  NESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKV-WAKGVSSSEMNVTW 833

Query: 995  EPVIPLANESEVVGYKVFYRQEGHSNSQV--IETQKLQA---VVPLPDAGVYIIEVRAYS 1049
            EPV    N   ++GY++ Y + G   +    + T  L     V  L     Y + VRAY+
Sbjct: 834  EPVQQDMN-GILLGYEIRYWKAGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYN 892

Query: 1050 EGGDGTAS 1057
              G G AS
Sbjct: 893  RAGTGPAS 900


>gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens]
          Length = 1018

 Score =  894 bits (2309), Expect = 0.0
 Identities = 452/972 (46%), Positives = 610/972 (62%), Gaps = 14/972 (1%)

Query: 92   DESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYS 151
            +E   +GP+F ++P + I+P +S E KV+LNC  R +P P Y+W  N  ++DL SD RYS
Sbjct: 34   EEDKGFGPIFEEQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMNNGDVDLTSD-RYS 92

Query: 152  LIDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQ 211
            ++ G  +I+NP + KD+G Y CLA+N  G + S EATL F YL  F    R  V V+EG+
Sbjct: 93   MVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGK 152

Query: 212  GVVLMCSPPPHSPE-IIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICL 270
            G+VL+C PP H P+ + Y W+ NEFP F+  D RRF+SQ  GNLYI+ V+ SD G+Y C 
Sbjct: 153  GMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCF 212

Query: 271  VKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVP 330
            V +      V S   PL    +     Y   I V F   V A  G  V +ECFALGNPVP
Sbjct: 213  VSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFK-DVYALMGQNVTLECFALGNPVP 271

Query: 331  TITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYP 390
             I W KV   +PS A +  S AVL+I N+QL+D GIYEC AEN RGK+  + ++ V  +P
Sbjct: 272  DIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFP 331

Query: 391  HWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQ 450
             WVE +NDT++D GS L W C ATGKP PT RWLKNG             G L +++V  
Sbjct: 332  EWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYH--------KGELRLYDVTF 383

Query: 451  SDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPK 510
             +AGMYQC+AEN YGAIYA+AELKILA APTF +N +KK I+  K   V+IECKP+ +PK
Sbjct: 384  ENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPK 443

Query: 511  PTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKE 570
            P  SW KG   +  + RI I  DGSL I N +++D G Y C  EN  G A    +L + +
Sbjct: 444  PKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITD 503

Query: 571  PTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQA 630
            PTRI L P   ++TVGE+  + C A  D +LD+TF W+  G  IDF +E  H++      
Sbjct: 504  PTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLD 563

Query: 631  SSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLS 690
            S+ +L+IRN  L HAGRY C  QT  D+ S  A+L+VRGPPGPPG + +E+I  ++  L+
Sbjct: 564  SNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALT 623

Query: 691  WSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVA 750
            WS  +DNHSPIS Y +Q ++  S  W+  KT P II G+ME+A AVDL PW+EYEFRVVA
Sbjct: 624  WSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVA 683

Query: 751  TNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYI 810
            TN +G G+PS PS  I+T+ A P  AP++V G  GR  EL I W P+S E+  G  FGYI
Sbjct: 684  TNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYI 743

Query: 811  VAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICS 870
            VAF+P     WK+  VT+ +  +++++DE++ P T F+VKV  +NNKGDGP+S + VI S
Sbjct: 744  VAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINS 803

Query: 871  AEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRG 930
            A+  PS APT+V    +S SEI V W+H+ E +   + +++ YW   ++E+ A  V+   
Sbjct: 804  AQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKI--VESYQIRYWAAHDKEEAANRVQVTS 861

Query: 931  NESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQV 990
             E    L  L  +T Y   V A N AG GPPS  + A TKK+PPSQ P  +   + GS+ 
Sbjct: 862  QEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRY 921

Query: 991  SLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEVRAYSE 1050
             + W+ V+ L+NES V GYKV YR +G  + ++  T K    VP+P  G Y++EVRA+S+
Sbjct: 922  IITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKHSIEVPIPRDGEYVVEVRAHSD 981

Query: 1051 GGDGTASSQIRV 1062
            GGDG   SQ+++
Sbjct: 982  GGDGVV-SQVKI 992


>gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens]
          Length = 1007

 Score =  894 bits (2309), Expect = 0.0
 Identities = 452/972 (46%), Positives = 610/972 (62%), Gaps = 14/972 (1%)

Query: 92   DESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYS 151
            +E   +GP+F ++P + I+P +S E KV+LNC  R +P P Y+W  N  ++DL SD RYS
Sbjct: 23   EEDKGFGPIFEEQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMNNGDVDLTSD-RYS 81

Query: 152  LIDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQ 211
            ++ G  +I+NP + KD+G Y CLA+N  G + S EATL F YL  F    R  V V+EG+
Sbjct: 82   MVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGK 141

Query: 212  GVVLMCSPPPHSPE-IIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICL 270
            G+VL+C PP H P+ + Y W+ NEFP F+  D RRF+SQ  GNLYI+ V+ SD G+Y C 
Sbjct: 142  GMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCF 201

Query: 271  VKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVP 330
            V +      V S   PL    +     Y   I V F   V A  G  V +ECFALGNPVP
Sbjct: 202  VSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFK-DVYALMGQNVTLECFALGNPVP 260

Query: 331  TITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYP 390
             I W KV   +PS A +  S AVL+I N+QL+D GIYEC AEN RGK+  + ++ V  +P
Sbjct: 261  DIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFP 320

Query: 391  HWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQ 450
             WVE +NDT++D GS L W C ATGKP PT RWLKNG             G L +++V  
Sbjct: 321  EWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYH--------KGELRLYDVTF 372

Query: 451  SDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPK 510
             +AGMYQC+AEN YGAIYA+AELKILA APTF +N +KK I+  K   V+IECKP+ +PK
Sbjct: 373  ENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPK 432

Query: 511  PTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKE 570
            P  SW KG   +  + RI I  DGSL I N +++D G Y C  EN  G A    +L + +
Sbjct: 433  PKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITD 492

Query: 571  PTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQA 630
            PTRI L P   ++TVGE+  + C A  D +LD+TF W+  G  IDF +E  H++      
Sbjct: 493  PTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLD 552

Query: 631  SSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLS 690
            S+ +L+IRN  L HAGRY C  QT  D+ S  A+L+VRGPPGPPG + +E+I  ++  L+
Sbjct: 553  SNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALT 612

Query: 691  WSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVA 750
            WS  +DNHSPIS Y +Q ++  S  W+  KT P II G+ME+A AVDL PW+EYEFRVVA
Sbjct: 613  WSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVA 672

Query: 751  TNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYI 810
            TN +G G+PS PS  I+T+ A P  AP++V G  GR  EL I W P+S E+  G  FGYI
Sbjct: 673  TNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYI 732

Query: 811  VAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICS 870
            VAF+P     WK+  VT+ +  +++++DE++ P T F+VKV  +NNKGDGP+S + VI S
Sbjct: 733  VAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINS 792

Query: 871  AEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRG 930
            A+  PS APT+V    +S SEI V W+H+ E +   + +++ YW   ++E+ A  V+   
Sbjct: 793  AQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKI--VESYQIRYWAAHDKEEAANRVQVTS 850

Query: 931  NESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQV 990
             E    L  L  +T Y   V A N AG GPPS  + A TKK+PPSQ P  +   + GS+ 
Sbjct: 851  QEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRY 910

Query: 991  SLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEVRAYSE 1050
             + W+ V+ L+NES V GYKV YR +G  + ++  T K    VP+P  G Y++EVRA+S+
Sbjct: 911  IITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKHSIEVPIPRDGEYVVEVRAHSD 970

Query: 1051 GGDGTASSQIRV 1062
            GGDG   SQ+++
Sbjct: 971  GGDGVV-SQVKI 981


>gi|28373126 contactin 4 isoform c precursor [Homo sapiens]
          Length = 698

 Score =  734 bits (1895), Expect = 0.0
 Identities = 358/687 (52%), Positives = 471/687 (68%), Gaps = 7/687 (1%)

Query: 409  WECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIY 468
            WECKA G+P+PTY+WLKNG PL  + R+++  G L I  VN SDAGMYQCLAENK+G I+
Sbjct: 7    WECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIF 66

Query: 469  ASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRI 528
            ++AEL ++A  P F+   LK+  +V    EVVIECKP+ SPKP  +WKKG   ++EN+RI
Sbjct: 67   SNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERI 126

Query: 529  AILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGES 588
             I  DG+LRI+N +KSD G Y C   N FG+A    +L VK+PTR+ + P   ++TVGES
Sbjct: 127  TISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGES 186

Query: 589  IVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRY 648
            IVL C+  HD SLD+ F W+  G  IDF+ +G HFE +  Q S+ DLMIRNI L HAG+Y
Sbjct: 187  IVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKY 246

Query: 649  GCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQA 708
             C VQT+ D +S  A+L+VRGPPGPP  V ++EIT++TA LSW P  DNHSPI+ Y +QA
Sbjct: 247  VCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQA 306

Query: 709  RSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRT 768
            R+PFS+GWQ V TVPE+I G   +A  V LNPWVEYEFR VA N IG G+PS PS   RT
Sbjct: 307  RTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRT 366

Query: 769  NEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTS 828
             EA+P+  P NVSG  G + ELVI WE V EE QNG GFGY+VAFRP G   W   ++ S
Sbjct: 367  EEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLAS 426

Query: 829  SEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVS 888
            ++AS++++R+ESV P +PFEVKVGV+NNKG+GPFS   V+ SAE EP+  P  + A S+S
Sbjct: 427  ADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLS 486

Query: 889  VSEILVAWKH-IKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYH 947
             ++I V W   ++++ GR QG+EV YW+  ++E+ A  ++T GN++   +T L+G+ LYH
Sbjct: 487  ATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYH 546

Query: 948  FTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVV 1007
              V+AYN AG GP S+ V+ TT+K PPSQ P N+ W    S++ L W+ V  L NESEV 
Sbjct: 547  LAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVK 606

Query: 1008 GYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQIRVPSYS- 1066
            GYKV YR    S++ VIET K    + LP    YIIE++ +S+GGDG++S QIR+P  S 
Sbjct: 607  GYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIRIPKISN 666

Query: 1067 -----GGKITSAQSTLHSLSTSSSSVT 1088
                  G  TS   TL ++ST   S+T
Sbjct: 667  AYARGSGASTSNACTLSAISTIMISLT 693



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 80/267 (29%), Positives = 115/267 (43%), Gaps = 22/267 (8%)

Query: 321 ECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSF 380
           EC A G P PT  W+K    + ++ R++  Q  L I  V L DAG+Y+C AEN  G    
Sbjct: 8   ECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFS 67

Query: 381 RGQLQVYTY-PHWVEKL--NDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVE 437
             +L V    P +   L    T +  G  +  ECK    P+P Y W K    L    R+ 
Sbjct: 68  NAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERIT 127

Query: 438 M-VNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKD 496
           +  +G L I NV +SDAG Y C+A N +G   AS+   ++   PT  +     ++ VT  
Sbjct: 128 ISEDGNLRIINVTKSDAGSYTCIATNHFGT--ASSTGNLVVKDPTRVMVP-PSSMDVTVG 184

Query: 497 QEVVIECK--PQGSPKPTISW----------KKGDRAVRENKRIAILPDGSLRILNASKS 544
           + +V+ C+     S     +W          + GD   R   + +    G L I N    
Sbjct: 185 ESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSA---GDLMIRNIQLK 241

Query: 545 DEGKYVCRGENVFGSAEIIASLSVKEP 571
             GKYVC  +         A L V+ P
Sbjct: 242 HAGKYVCMVQTSVDRLSAAADLIVRGP 268



 Score = 87.0 bits (214), Expect = 9e-17
 Identities = 164/729 (22%), Positives = 265/729 (36%), Gaps = 121/729 (16%)

Query: 116 EKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLA 175
           E+ V   C+  G P P+Y+WL+NG  + L  D R  +  GT  I+  +   D+G YQCLA
Sbjct: 2   EENVFWECKANGRPKPTYKWLKNGEPL-LTRD-RIQIEQGTLNITIVN-LSDAGMYQCLA 58

Query: 176 TNTVGSILSREATLQFAYLGNFSGRT--RSAVSVREGQGVVLMCSPPPHSPEIIYSWVFN 233
            N  G I S  A L    +G    RT  +    V+ G  VV+ C P   SP+ +Y+W   
Sbjct: 59  ENKHGVIFS-NAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKA-SPKPVYTW--- 113

Query: 234 EFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNA------------RVL 281
           +    + +++ R    E GNL I  V  SD GSY C+  N    A            RV+
Sbjct: 114 KKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVM 173

Query: 282 SPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYI 341
            PP+ +    D  +GE      +  P  VT      +              TW   NG++
Sbjct: 174 VPPSSM----DVTVGE-----SIVLPCQVTHDHSLDI------------VFTW-SFNGHL 211

Query: 342 P---------SKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHW 392
                      +   + S   L I N+QL  AG Y C  + S  + S    L V   P  
Sbjct: 212 IDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGP 271

Query: 393 VEKLN-DTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSP---QSRVEMVNGVLMIHNV 448
            E +  D   D+ + L W      +P P      N  P++    Q+R     G   +  V
Sbjct: 272 PEAVTIDEITDTTAQLSW------RPGP-----DNHSPITMYVIQARTPFSVGWQAVSTV 320

Query: 449 NQSDAGMYQCLAENKYGA-IYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQ- 506
            +   G  +       G   +   E + +A A    + +  +     + +E + E  P  
Sbjct: 321 PELIDG--KTFTATVVGLNPWVEYEFRTVA-ANVIGIGEPSRPSEKRRTEEALPEVTPAN 377

Query: 507 ----GSPKP--TISWKKGDRAVRENKR----IAILPDGSL--RILNASKSDEGKYVCRGE 554
               G  K    I+W+     ++  +     +A  P G +   +   + +D  +YV R E
Sbjct: 378 VSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNE 437

Query: 555 NVFGSAEIIASLSV-KEPTRIELTPKRTELTVGESIVLNCKAIHDASL---DVTFYWT-- 608
           +V   +     + V         +P     +  E       +I   SL   D+  +W   
Sbjct: 438 SVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASP 497

Query: 609 -------LKGQPI------DFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTT 655
                  ++G  +      D EE      ++  Q S+    ++  +L H          T
Sbjct: 498 LEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGT 557

Query: 656 ADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWS--PAADNHSPISSYNLQARSPFS 713
             S +       + PP  P   I+   ++S   L+W    A DN S +  Y +  R    
Sbjct: 558 GPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYR---- 613

Query: 714 LGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVP 773
             W    +   I T      +++  +     E  ++   P   G   + S  IR    +P
Sbjct: 614 --WNRQSSTSVIETNKTSVELSLPFD-----EDYIIEIKPFSDGGDGSSSEQIR----IP 662

Query: 774 KTAPTNVSG 782
           K +     G
Sbjct: 663 KISNAYARG 671


>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
            sapiens]
          Length = 1248

 Score =  404 bits (1037), Expect = e-112
 Identities = 280/943 (29%), Positives = 451/943 (47%), Gaps = 70/943 (7%)

Query: 108  IIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLID----GTFIISNPS 163
            ++FPTD     ++L CE  G P   +RW R+G     + +   ++      G+F I+  +
Sbjct: 41   VVFPTDD----ISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNN 96

Query: 164  E---AKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPP 220
                 +  G Y+C A+N +G+ +S E  L       +   T   V V EG+ VVL C+PP
Sbjct: 97   SNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPP 156

Query: 221  PHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGS-YICLVKNTVTNAR 279
            P +  +   W+ N     + +D R  + Q  GNLY + V TSD  S YIC      T   
Sbjct: 157  PSAEPLRIYWM-NSKILHIKQDERVTMGQN-GNLYFANVLTSDNHSDYICHAHFPGTRTI 214

Query: 280  VLSPPTPLTLRNDGVMGEYEPKIEVHFPFT----VTAAKGTTVKMECFALGNPVPTITWM 335
            +   P  L ++    M + +P++   FP      + A +G  + +EC A G P PTI W+
Sbjct: 215  IQKEPIDLRVKATNSMIDRKPRLL--FPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWL 272

Query: 336  KVNGYIPS-KARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVE 394
            + +G +P+ +   +     L++  V  +D G Y C AENS G       + V   P+W+ 
Sbjct: 273  RPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLH 332

Query: 395  KLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVP---LSPQSRVEMVNGVLMIHNVNQS 451
            K        G   R +C+  G+P+P   W  NG+P   L+   +  +  G L++ NV  S
Sbjct: 333  KPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPS 392

Query: 452  DAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKP 511
            D  + QC A N++G + A+A + ++   P   L    +T +  +     + CK  G+P P
Sbjct: 393  DTMVTQCEARNRHGLLLANAYIYVV-QLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVP 451

Query: 512  TISWKKGD-RAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKE 570
            ++ W   D   V +++R     +G+L I +   +D G+Y C   N   +  I+A+L VK+
Sbjct: 452  SVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKD 511

Query: 571  PTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQA 630
             T+I   P+ T    G  +   C+A  D SL  +  W  +G   D +E G   +S +   
Sbjct: 512  ATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITW--RGDGRDLQELG---DSDKYFI 566

Query: 631  SSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEI---TESTA 687
                L+I ++     G Y C   T  D V   A+LLV G PGP   +++ ++   T+S  
Sbjct: 567  EDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQV 626

Query: 688  TLSWSPAADNHSPISSYNLQARSPFSLG--WQTVKTVPEIITGDMESAMAVDLNPWVEYE 745
             +SWSPA D+++PI  Y+++          W ++  VP       +++  + L+P+V Y 
Sbjct: 627  RVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVP-----GNQTSTTLKLSPYVHYT 681

Query: 746  FRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGE 805
            FRV A N  G G+PS  S  + T EA P+  P +V G       +VI W+P+     N  
Sbjct: 682  FRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAP 741

Query: 806  GFGYIVAFRPNGTRG-WKEKMVTS-----SEASKFIYRDESVPPLTPFEVKVGVYNNKGD 859
               Y V +RP GTRG W+E++V+      S  S F+          P+E+KV   N++G 
Sbjct: 742  QVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFV----------PYEIKVQAVNSQGK 791

Query: 860  GPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWK--HIKESLGRPQGFEVGYWKDM 917
            GP  Q+ +  S E  P A P       ++ S +LV W+   + +  G  +G+ V YW++ 
Sbjct: 792  GPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREG 851

Query: 918  EQEDTA------ETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKK 971
             Q   +      + V    N + VIL+GL   + YH  V+A+NG G G P+SE + +T +
Sbjct: 852  SQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSG-PASEFTFSTPE 910

Query: 972  SPPSQAPSNLRWE-QQGSQVSLGWEPVIPLANESEVVGYKVFY 1013
              P   P  L  E Q  + + L W+P  PL++   + GY + Y
Sbjct: 911  GVPGH-PEALHLECQSNTSLLLRWQP--PLSHNGVLTGYVLSY 950



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 160/698 (22%), Positives = 265/698 (37%), Gaps = 91/698 (13%)

Query: 404  GSPLRWECKATGKPRPTYRWLKNGVPLSPQSRV--EMVNGVLMIHNVNQSDAGMYQCLAE 461
            G PL  EC A G P PT +WL+   P+ P  RV  +  N  L +  V + D G Y+CLAE
Sbjct: 252  GQPLVLECIAEGFPTPTIKWLRPSGPM-PADRVTYQNHNKTLQLLKVGEEDDGEYRCLAE 310

Query: 462  NKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRA 521
            N  G+  A     +   A  + L++  ++ +    +   ++C+ QG P+P ++W+     
Sbjct: 311  NSLGS--ARHAYYVTVEAAPYWLHK-PQSHLYGPGETARLDCQVQGRPQPEVTWRINGIP 367

Query: 522  VRE--NKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKE-PTRIELTP 578
            V E    +   +  G+L + N   SD     C   N  G     A + V + P +I    
Sbjct: 368  VEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTAD 427

Query: 579  KRTELTV-GESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMI 637
             +T + V G +  L CKA   A +    +    G  +  +E    +       ++  L I
Sbjct: 428  NQTYMAVQGSTAYLLCKAF-GAPVPSVQWLDEDGTTVLQDERFFPY-------ANGTLGI 479

Query: 638  RNILLMHAGRYGCRVQTTADSVSDEAELLVRGPP----GPPGIVIVEEITESTATLSWSP 693
            R++     GRY C      ++V+  A L V+       GP   +   E   S  T +   
Sbjct: 480  RDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTI---EKKGSRVTFTCQA 536

Query: 694  AAD-NHSPISSYNLQARSPFSLGWQTVKTVPE--IITGDMESAMAVDLNPWVEYEFRVVA 750
            + D +  P  ++    R    LG      + +  ++   ++ +   + +     E  VV 
Sbjct: 537  SFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVE 596

Query: 751  TNP--IGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFG 808
            +    +  G P    R++ ++  +   +   VS      H   I  E    EF++ E   
Sbjct: 597  SRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPI--EKYDIEFEDKE--- 651

Query: 809  YIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDG---PFSQI 865
                  P   + +    V  ++ S  +     + P   +  +V   N  G G   P S+ 
Sbjct: 652  ----MAPE--KWYSLGKVPGNQTSTTL----KLSPYVHYTFRVTAINKYGPGEPSPVSET 701

Query: 866  VVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIK-----------ESLGRPQGFEVGYW 914
            VV  + E  P   P DVK      + +++ WK ++               RPQG   G W
Sbjct: 702  VV--TPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTR-GPW 758

Query: 915  KDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPP 974
            ++    D            F++++       Y   V+A N  G GP        + +  P
Sbjct: 759  QEQIVSDP-----------FLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYP 807

Query: 975  SQAPSNLRWE-QQGSQVSLGWEPVIPLANESEVVGYKVFYRQEG----HSNSQVIETQKL 1029
               P     E    S V + W PV     +  + GY V Y +EG    HS   +    K 
Sbjct: 808  QAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHI---HKD 864

Query: 1030 QAVVPLPDAGV----------YIIEVRAYSEGGDGTAS 1057
              VVP     V          Y +EV+A++  G G AS
Sbjct: 865  HVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPAS 902



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 31/139 (22%), Positives = 55/139 (39%), Gaps = 12/139 (8%)

Query: 480 PTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAIL-----PDG 534
           P     Q  + ++V    ++ ++C+  G P+    W +     +  + + +        G
Sbjct: 29  PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 88

Query: 535 SLRIL----NASKSDEGKYVCRGENVFGSA--EIIASLSVKEPTRIELTPKRTELTVGES 588
           S  I     N ++  +G Y C   N  G+A    I  ++   P   + T K  E+  GES
Sbjct: 89  SFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGES 148

Query: 589 IVLNCKAIHDASLDVTFYW 607
           +VL C     A   +  YW
Sbjct: 149 VVLPCNPPPSAE-PLRIYW 166



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 31/135 (22%), Positives = 60/135 (44%), Gaps = 19/135 (14%)

Query: 669  GPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTV----PE 724
            G PG P  + +E  + ++  L W P   ++  ++ Y L    P   G +   +     PE
Sbjct: 911  GVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYH-PLDEGGKGQLSFNLRDPE 969

Query: 725  IITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPT---NVS 781
            + T ++      DL+P + Y F++ AT   G G+      ++R    +  +  +   N+S
Sbjct: 970  LRTHNL-----TDLSPHLRYRFQLQATTKEGPGE-----AIVREGGTMALSGISDFGNIS 1019

Query: 782  GRSGRRHELVIAWEP 796
              +G  +  V++W P
Sbjct: 1020 ATAGENYS-VVSWVP 1033


>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
            sapiens]
          Length = 1253

 Score =  404 bits (1037), Expect = e-112
 Identities = 280/943 (29%), Positives = 451/943 (47%), Gaps = 70/943 (7%)

Query: 108  IIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLID----GTFIISNPS 163
            ++FPTD     ++L CE  G P   +RW R+G     + +   ++      G+F I+  +
Sbjct: 46   VVFPTDD----ISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNN 101

Query: 164  E---AKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPP 220
                 +  G Y+C A+N +G+ +S E  L       +   T   V V EG+ VVL C+PP
Sbjct: 102  SNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPP 161

Query: 221  PHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGS-YICLVKNTVTNAR 279
            P +  +   W+ N     + +D R  + Q  GNLY + V TSD  S YIC      T   
Sbjct: 162  PSAEPLRIYWM-NSKILHIKQDERVTMGQN-GNLYFANVLTSDNHSDYICHAHFPGTRTI 219

Query: 280  VLSPPTPLTLRNDGVMGEYEPKIEVHFPFT----VTAAKGTTVKMECFALGNPVPTITWM 335
            +   P  L ++    M + +P++   FP      + A +G  + +EC A G P PTI W+
Sbjct: 220  IQKEPIDLRVKATNSMIDRKPRLL--FPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWL 277

Query: 336  KVNGYIPS-KARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVE 394
            + +G +P+ +   +     L++  V  +D G Y C AENS G       + V   P+W+ 
Sbjct: 278  RPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLH 337

Query: 395  KLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVP---LSPQSRVEMVNGVLMIHNVNQS 451
            K        G   R +C+  G+P+P   W  NG+P   L+   +  +  G L++ NV  S
Sbjct: 338  KPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPS 397

Query: 452  DAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKP 511
            D  + QC A N++G + A+A + ++   P   L    +T +  +     + CK  G+P P
Sbjct: 398  DTMVTQCEARNRHGLLLANAYIYVV-QLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVP 456

Query: 512  TISWKKGD-RAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKE 570
            ++ W   D   V +++R     +G+L I +   +D G+Y C   N   +  I+A+L VK+
Sbjct: 457  SVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKD 516

Query: 571  PTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQA 630
             T+I   P+ T    G  +   C+A  D SL  +  W  +G   D +E G   +S +   
Sbjct: 517  ATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITW--RGDGRDLQELG---DSDKYFI 571

Query: 631  SSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEI---TESTA 687
                L+I ++     G Y C   T  D V   A+LLV G PGP   +++ ++   T+S  
Sbjct: 572  EDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQV 631

Query: 688  TLSWSPAADNHSPISSYNLQARSPFSLG--WQTVKTVPEIITGDMESAMAVDLNPWVEYE 745
             +SWSPA D+++PI  Y+++          W ++  VP       +++  + L+P+V Y 
Sbjct: 632  RVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVP-----GNQTSTTLKLSPYVHYT 686

Query: 746  FRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGE 805
            FRV A N  G G+PS  S  + T EA P+  P +V G       +VI W+P+     N  
Sbjct: 687  FRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAP 746

Query: 806  GFGYIVAFRPNGTRG-WKEKMVTS-----SEASKFIYRDESVPPLTPFEVKVGVYNNKGD 859
               Y V +RP GTRG W+E++V+      S  S F+          P+E+KV   N++G 
Sbjct: 747  QVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFV----------PYEIKVQAVNSQGK 796

Query: 860  GPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWK--HIKESLGRPQGFEVGYWKDM 917
            GP  Q+ +  S E  P A P       ++ S +LV W+   + +  G  +G+ V YW++ 
Sbjct: 797  GPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREG 856

Query: 918  EQEDTA------ETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKK 971
             Q   +      + V    N + VIL+GL   + YH  V+A+NG G G P+SE + +T +
Sbjct: 857  SQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSG-PASEFTFSTPE 915

Query: 972  SPPSQAPSNLRWE-QQGSQVSLGWEPVIPLANESEVVGYKVFY 1013
              P   P  L  E Q  + + L W+P  PL++   + GY + Y
Sbjct: 916  GVPGH-PEALHLECQSNTSLLLRWQP--PLSHNGVLTGYVLSY 955



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 160/698 (22%), Positives = 265/698 (37%), Gaps = 91/698 (13%)

Query: 404  GSPLRWECKATGKPRPTYRWLKNGVPLSPQSRV--EMVNGVLMIHNVNQSDAGMYQCLAE 461
            G PL  EC A G P PT +WL+   P+ P  RV  +  N  L +  V + D G Y+CLAE
Sbjct: 257  GQPLVLECIAEGFPTPTIKWLRPSGPM-PADRVTYQNHNKTLQLLKVGEEDDGEYRCLAE 315

Query: 462  NKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRA 521
            N  G+  A     +   A  + L++  ++ +    +   ++C+ QG P+P ++W+     
Sbjct: 316  NSLGS--ARHAYYVTVEAAPYWLHK-PQSHLYGPGETARLDCQVQGRPQPEVTWRINGIP 372

Query: 522  VRE--NKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKE-PTRIELTP 578
            V E    +   +  G+L + N   SD     C   N  G     A + V + P +I    
Sbjct: 373  VEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTAD 432

Query: 579  KRTELTV-GESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMI 637
             +T + V G +  L CKA   A +    +    G  +  +E    +       ++  L I
Sbjct: 433  NQTYMAVQGSTAYLLCKAF-GAPVPSVQWLDEDGTTVLQDERFFPY-------ANGTLGI 484

Query: 638  RNILLMHAGRYGCRVQTTADSVSDEAELLVRGPP----GPPGIVIVEEITESTATLSWSP 693
            R++     GRY C      ++V+  A L V+       GP   +   E   S  T +   
Sbjct: 485  RDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTI---EKKGSRVTFTCQA 541

Query: 694  AAD-NHSPISSYNLQARSPFSLGWQTVKTVPE--IITGDMESAMAVDLNPWVEYEFRVVA 750
            + D +  P  ++    R    LG      + +  ++   ++ +   + +     E  VV 
Sbjct: 542  SFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVE 601

Query: 751  TNP--IGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFG 808
            +    +  G P    R++ ++  +   +   VS      H   I  E    EF++ E   
Sbjct: 602  SRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPI--EKYDIEFEDKE--- 656

Query: 809  YIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDG---PFSQI 865
                  P   + +    V  ++ S  +     + P   +  +V   N  G G   P S+ 
Sbjct: 657  ----MAPE--KWYSLGKVPGNQTSTTL----KLSPYVHYTFRVTAINKYGPGEPSPVSET 706

Query: 866  VVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIK-----------ESLGRPQGFEVGYW 914
            VV  + E  P   P DVK      + +++ WK ++               RPQG   G W
Sbjct: 707  VV--TPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTR-GPW 763

Query: 915  KDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPP 974
            ++    D            F++++       Y   V+A N  G GP        + +  P
Sbjct: 764  QEQIVSDP-----------FLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYP 812

Query: 975  SQAPSNLRWE-QQGSQVSLGWEPVIPLANESEVVGYKVFYRQEG----HSNSQVIETQKL 1029
               P     E    S V + W PV     +  + GY V Y +EG    HS   +    K 
Sbjct: 813  QAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHI---HKD 869

Query: 1030 QAVVPLPDAGV----------YIIEVRAYSEGGDGTAS 1057
              VVP     V          Y +EV+A++  G G AS
Sbjct: 870  HVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPAS 907



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 31/139 (22%), Positives = 55/139 (39%), Gaps = 12/139 (8%)

Query: 480 PTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAIL-----PDG 534
           P     Q  + ++V    ++ ++C+  G P+    W +     +  + + +        G
Sbjct: 34  PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 93

Query: 535 SLRIL----NASKSDEGKYVCRGENVFGSA--EIIASLSVKEPTRIELTPKRTELTVGES 588
           S  I     N ++  +G Y C   N  G+A    I  ++   P   + T K  E+  GES
Sbjct: 94  SFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGES 153

Query: 589 IVLNCKAIHDASLDVTFYW 607
           +VL C     A   +  YW
Sbjct: 154 VVLPCNPPPSAE-PLRIYW 171



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 31/135 (22%), Positives = 60/135 (44%), Gaps = 19/135 (14%)

Query: 669  GPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTV----PE 724
            G PG P  + +E  + ++  L W P   ++  ++ Y L    P   G +   +     PE
Sbjct: 916  GVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYH-PLDEGGKGQLSFNLRDPE 974

Query: 725  IITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPT---NVS 781
            + T ++      DL+P + Y F++ AT   G G+      ++R    +  +  +   N+S
Sbjct: 975  LRTHNL-----TDLSPHLRYRFQLQATTKEGPGE-----AIVREGGTMALSGISDFGNIS 1024

Query: 782  GRSGRRHELVIAWEP 796
              +G  +  V++W P
Sbjct: 1025 ATAGENYS-VVSWVP 1038


>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
            sapiens]
          Length = 1257

 Score =  404 bits (1037), Expect = e-112
 Identities = 280/943 (29%), Positives = 451/943 (47%), Gaps = 70/943 (7%)

Query: 108  IIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLID----GTFIISNPS 163
            ++FPTD     ++L CE  G P   +RW R+G     + +   ++      G+F I+  +
Sbjct: 46   VVFPTDD----ISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNN 101

Query: 164  E---AKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPP 220
                 +  G Y+C A+N +G+ +S E  L       +   T   V V EG+ VVL C+PP
Sbjct: 102  SNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPP 161

Query: 221  PHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGS-YICLVKNTVTNAR 279
            P +  +   W+ N     + +D R  + Q  GNLY + V TSD  S YIC      T   
Sbjct: 162  PSAEPLRIYWM-NSKILHIKQDERVTMGQN-GNLYFANVLTSDNHSDYICHAHFPGTRTI 219

Query: 280  VLSPPTPLTLRNDGVMGEYEPKIEVHFPFT----VTAAKGTTVKMECFALGNPVPTITWM 335
            +   P  L ++    M + +P++   FP      + A +G  + +EC A G P PTI W+
Sbjct: 220  IQKEPIDLRVKATNSMIDRKPRLL--FPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWL 277

Query: 336  KVNGYIPS-KARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVE 394
            + +G +P+ +   +     L++  V  +D G Y C AENS G       + V   P+W+ 
Sbjct: 278  RPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLH 337

Query: 395  KLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVP---LSPQSRVEMVNGVLMIHNVNQS 451
            K        G   R +C+  G+P+P   W  NG+P   L+   +  +  G L++ NV  S
Sbjct: 338  KPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPS 397

Query: 452  DAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKP 511
            D  + QC A N++G + A+A + ++   P   L    +T +  +     + CK  G+P P
Sbjct: 398  DTMVTQCEARNRHGLLLANAYIYVV-QLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVP 456

Query: 512  TISWKKGD-RAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKE 570
            ++ W   D   V +++R     +G+L I +   +D G+Y C   N   +  I+A+L VK+
Sbjct: 457  SVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKD 516

Query: 571  PTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQA 630
             T+I   P+ T    G  +   C+A  D SL  +  W  +G   D +E G   +S +   
Sbjct: 517  ATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITW--RGDGRDLQELG---DSDKYFI 571

Query: 631  SSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEI---TESTA 687
                L+I ++     G Y C   T  D V   A+LLV G PGP   +++ ++   T+S  
Sbjct: 572  EDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQV 631

Query: 688  TLSWSPAADNHSPISSYNLQARSPFSLG--WQTVKTVPEIITGDMESAMAVDLNPWVEYE 745
             +SWSPA D+++PI  Y+++          W ++  VP       +++  + L+P+V Y 
Sbjct: 632  RVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVP-----GNQTSTTLKLSPYVHYT 686

Query: 746  FRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGE 805
            FRV A N  G G+PS  S  + T EA P+  P +V G       +VI W+P+     N  
Sbjct: 687  FRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAP 746

Query: 806  GFGYIVAFRPNGTRG-WKEKMVTS-----SEASKFIYRDESVPPLTPFEVKVGVYNNKGD 859
               Y V +RP GTRG W+E++V+      S  S F+          P+E+KV   N++G 
Sbjct: 747  QVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFV----------PYEIKVQAVNSQGK 796

Query: 860  GPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWK--HIKESLGRPQGFEVGYWKDM 917
            GP  Q+ +  S E  P A P       ++ S +LV W+   + +  G  +G+ V YW++ 
Sbjct: 797  GPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREG 856

Query: 918  EQEDTA------ETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKK 971
             Q   +      + V    N + VIL+GL   + YH  V+A+NG G G P+SE + +T +
Sbjct: 857  SQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSG-PASEFTFSTPE 915

Query: 972  SPPSQAPSNLRWE-QQGSQVSLGWEPVIPLANESEVVGYKVFY 1013
              P   P  L  E Q  + + L W+P  PL++   + GY + Y
Sbjct: 916  GVPGH-PEALHLECQSNTSLLLRWQP--PLSHNGVLTGYVLSY 955



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 160/698 (22%), Positives = 265/698 (37%), Gaps = 91/698 (13%)

Query: 404  GSPLRWECKATGKPRPTYRWLKNGVPLSPQSRV--EMVNGVLMIHNVNQSDAGMYQCLAE 461
            G PL  EC A G P PT +WL+   P+ P  RV  +  N  L +  V + D G Y+CLAE
Sbjct: 257  GQPLVLECIAEGFPTPTIKWLRPSGPM-PADRVTYQNHNKTLQLLKVGEEDDGEYRCLAE 315

Query: 462  NKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRA 521
            N  G+  A     +   A  + L++  ++ +    +   ++C+ QG P+P ++W+     
Sbjct: 316  NSLGS--ARHAYYVTVEAAPYWLHK-PQSHLYGPGETARLDCQVQGRPQPEVTWRINGIP 372

Query: 522  VRE--NKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKE-PTRIELTP 578
            V E    +   +  G+L + N   SD     C   N  G     A + V + P +I    
Sbjct: 373  VEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTAD 432

Query: 579  KRTELTV-GESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMI 637
             +T + V G +  L CKA   A +    +    G  +  +E    +       ++  L I
Sbjct: 433  NQTYMAVQGSTAYLLCKAF-GAPVPSVQWLDEDGTTVLQDERFFPY-------ANGTLGI 484

Query: 638  RNILLMHAGRYGCRVQTTADSVSDEAELLVRGPP----GPPGIVIVEEITESTATLSWSP 693
            R++     GRY C      ++V+  A L V+       GP   +   E   S  T +   
Sbjct: 485  RDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTI---EKKGSRVTFTCQA 541

Query: 694  AAD-NHSPISSYNLQARSPFSLGWQTVKTVPE--IITGDMESAMAVDLNPWVEYEFRVVA 750
            + D +  P  ++    R    LG      + +  ++   ++ +   + +     E  VV 
Sbjct: 542  SFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVE 601

Query: 751  TNP--IGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFG 808
            +    +  G P    R++ ++  +   +   VS      H   I  E    EF++ E   
Sbjct: 602  SRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPI--EKYDIEFEDKE--- 656

Query: 809  YIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDG---PFSQI 865
                  P   + +    V  ++ S  +     + P   +  +V   N  G G   P S+ 
Sbjct: 657  ----MAPE--KWYSLGKVPGNQTSTTL----KLSPYVHYTFRVTAINKYGPGEPSPVSET 706

Query: 866  VVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIK-----------ESLGRPQGFEVGYW 914
            VV  + E  P   P DVK      + +++ WK ++               RPQG   G W
Sbjct: 707  VV--TPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTR-GPW 763

Query: 915  KDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPP 974
            ++    D            F++++       Y   V+A N  G GP        + +  P
Sbjct: 764  QEQIVSDP-----------FLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYP 812

Query: 975  SQAPSNLRWE-QQGSQVSLGWEPVIPLANESEVVGYKVFYRQEG----HSNSQVIETQKL 1029
               P     E    S V + W PV     +  + GY V Y +EG    HS   +    K 
Sbjct: 813  QAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHI---HKD 869

Query: 1030 QAVVPLPDAGV----------YIIEVRAYSEGGDGTAS 1057
              VVP     V          Y +EV+A++  G G AS
Sbjct: 870  HVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPAS 907



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 31/139 (22%), Positives = 55/139 (39%), Gaps = 12/139 (8%)

Query: 480 PTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAIL-----PDG 534
           P     Q  + ++V    ++ ++C+  G P+    W +     +  + + +        G
Sbjct: 34  PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 93

Query: 535 SLRIL----NASKSDEGKYVCRGENVFGSA--EIIASLSVKEPTRIELTPKRTELTVGES 588
           S  I     N ++  +G Y C   N  G+A    I  ++   P   + T K  E+  GES
Sbjct: 94  SFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGES 153

Query: 589 IVLNCKAIHDASLDVTFYW 607
           +VL C     A   +  YW
Sbjct: 154 VVLPCNPPPSAE-PLRIYW 171



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 31/135 (22%), Positives = 60/135 (44%), Gaps = 19/135 (14%)

Query: 669  GPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTV----PE 724
            G PG P  + +E  + ++  L W P   ++  ++ Y L    P   G +   +     PE
Sbjct: 916  GVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYH-PLDEGGKGQLSFNLRDPE 974

Query: 725  IITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPT---NVS 781
            + T ++      DL+P + Y F++ AT   G G+      ++R    +  +  +   N+S
Sbjct: 975  LRTHNL-----TDLSPHLRYRFQLQATTKEGPGE-----AIVREGGTMALSGISDFGNIS 1024

Query: 782  GRSGRRHELVIAWEP 796
              +G  +  V++W P
Sbjct: 1025 ATAGENYS-VVSWVP 1038


>gi|237858679 neurofascin isoform 3 precursor [Homo sapiens]
          Length = 1174

 Score =  368 bits (945), Expect = e-101
 Identities = 280/953 (29%), Positives = 427/953 (44%), Gaps = 76/953 (7%)

Query: 106  DDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI--DGTFIISNPS 163
            D I+ P D+    + + CE +GNP PS+ W RN    ++  D R S+    GT +I   S
Sbjct: 44   DHIVDPRDN----ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 99

Query: 164  EAKDS---GHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPP 220
              +     G YQC A N  G+ LS    LQ +    +       V V+EG  + L C+PP
Sbjct: 100  GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPP 159

Query: 221  PHSPEIIYSWVFNEFPSFVAEDSRRFISQ-ETGNLYISKVQTSDVGS-YICLVKNTVTNA 278
            P  P  +  W+ +     + +D R  +SQ   G+LY S V   D+ + Y C  +   T+ 
Sbjct: 160  PGLPSPVIFWMSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHT 216

Query: 279  ---------RVLS--PPTPLTLRNDGVM----GEYEPKIEVHFPFTVTAA----KGTTVK 319
                     +VL+  P    +LRN   M    G  E      +P    ++    +G  + 
Sbjct: 217  IQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLL 276

Query: 320  MECFALGNPVPTITWMKVNGYIPS-KARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKN 378
            +EC A G P P I W K  G +PS KA+       L I NV  +D+G Y C A N  G  
Sbjct: 277  LECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSI 336

Query: 379  SFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLS---PQSR 435
                 ++V   P+W+++  +  L  G   R  C+A G P+PT +W+ NG PL    P   
Sbjct: 337  RHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPN 396

Query: 436  VEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFAL--NQLKKTIIV 493
             E+    ++  +   S   +YQC   N++G + A+A + +L   P      NQL + I+ 
Sbjct: 397  REVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILY 456

Query: 494  TKDQEVVIECKPQGSPKPTISW-KKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCR 552
             + +   ++C   GSP PT+ W K G  +  +     +  +GSL I    K D+G Y C 
Sbjct: 457  NRTR---LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCV 513

Query: 553  GENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQ 612
              N+ G AE    L VK+PTRI   P+      G ++ L C+  HD SL +T  W    +
Sbjct: 514  ATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDE 573

Query: 613  PIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPG 672
            P+        +   R +     L I  +     G Y C   T  D    +A L V G P 
Sbjct: 574  PL--------YIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPD 625

Query: 673  PPGIVIVEEITESTATLSWSPAADNHSPISSYNLQ-ARSPFSLG-WQTVKTVPEIITGDM 730
             P  + + ++ E +  L+W P   N+SPI+ Y +Q     F  G W      P    G +
Sbjct: 626  RPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYP----GSV 681

Query: 731  ESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHEL 790
             SA+ + L+P+V Y+FRV+A N +G+  PS PS   RT+ A P++ P +V G   R++ +
Sbjct: 682  NSAV-LRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNM 740

Query: 791  VIAWEPVSEEFQNGEGFGYIVAFRPNGTR-GWKEKMVTSSEASKFIYRDESVPPLTPFEV 849
             I W P++     G    YIV +R   TR  W    V  S      Y     P   P+E+
Sbjct: 741  EITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSR-----YVVGQTPVYVPYEI 795

Query: 850  KVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESL--GRPQ 907
            +V   N+ G GP  + V+  S E  P AAPT+VK   ++ + I + W  +      G+ +
Sbjct: 796  RVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLR 855

Query: 908  GFEVGYWKDMEQEDTAETVKTRGNESFV------ILTGLEGNTLYHFTVRAYNGAGYGPP 961
             +   YW++          + R   SF       +++ L   + Y   +   NG G GP 
Sbjct: 856  EYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPR 915

Query: 962  SSEVSATTKKSPPSQAPSNLRWEQQGSQ-VSLGWEPVIPLANESEVVGYKVFY 1013
            S     TT +  PS AP   R  Q   + ++L W+   P      ++GY + Y
Sbjct: 916  SETKEFTTPEGVPS-APRRFRVRQPNLETINLEWDH--PEHPNGIMIGYTLKY 965



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 65/321 (20%), Positives = 121/321 (37%), Gaps = 55/321 (17%)

Query: 394 EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKN----GVPLSPQSRVEMVNGVLMIH--- 446
           +   D  +D    +  EC+A G P P++ W +N     +   P+  +   +G L+I    
Sbjct: 40  QSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 99

Query: 447 -NVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECK- 504
               +   G YQC A NK+G   ++     ++ +P +    L   ++V +   + ++C  
Sbjct: 100 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENL-DPVVVQEGAPLTLQCNP 158

Query: 505 PQGSPKPTISWKKGD-RAVRENKRIAILPDGSLRILNASKSD-EGKYVCRGENVF----- 557
           P G P P I W       + ++KR++   +G L   N    D +  Y C     F     
Sbjct: 159 PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQ 218

Query: 558 ---------------------GSAEIIASLSVKEPTRIELTPKRTE----LTVGESIVLN 592
                                   ++ ++  V E T   + P+ T     +  G  ++L 
Sbjct: 219 QKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLE 278

Query: 593 CKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSAD--LMIRNILLMHAGRYGC 650
           C A    + D+ +Y           ++GG   S +A+  + +  L I N+    +G Y C
Sbjct: 279 CIASGVPTPDIAWY-----------KKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFC 327

Query: 651 RVQTTADSVSDEAELLVRGPP 671
                  S+     + V+  P
Sbjct: 328 LASNKMGSIRHTISVRVKAAP 348



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 38/178 (21%), Positives = 76/178 (42%), Gaps = 21/178 (11%)

Query: 476 LASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDR--AVRENKRIAILPD 533
           L   PT      K  I+  +D  ++IEC+ +G+P P+  W +  R   + ++ R+++   
Sbjct: 31  LTQPPTITKQSAKDHIVDPRDN-ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR 89

Query: 534 GSLRILN-----ASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKR----TELT 584
               +++       +  EG+Y C   N FG+A  +++    + ++  L PK       + 
Sbjct: 90  SGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA--LSNRIRLQVSKSPLWPKENLDPVVVQ 147

Query: 585 VGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILL 642
            G  + L C         V F+ +   +PI  ++         +Q  + DL   N++L
Sbjct: 148 EGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKR-------VSQGHNGDLYFSNVML 198



 Score = 31.2 bits (69), Expect = 5.6
 Identities = 27/111 (24%), Positives = 42/111 (37%), Gaps = 2/111 (1%)

Query: 669  GPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITG 728
            G P  P    V +    T  L W      +  +  Y L+  + F+ G +  K + E  + 
Sbjct: 926  GVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVA-FN-GTKVGKQIVENFSP 983

Query: 729  DMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTN 779
            +         +P   Y F + A   +G+G+  T       NEA P  A TN
Sbjct: 984  NQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAAYTN 1034


>gi|89903008 neurofascin isoform 4 precursor [Homo sapiens]
          Length = 1169

 Score =  368 bits (945), Expect = e-101
 Identities = 280/953 (29%), Positives = 427/953 (44%), Gaps = 76/953 (7%)

Query: 106  DDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI--DGTFIISNPS 163
            D I+ P D+    + + CE +GNP PS+ W RN    ++  D R S+    GT +I   S
Sbjct: 44   DHIVDPRDN----ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 99

Query: 164  EAKDS---GHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPP 220
              +     G YQC A N  G+ LS    LQ +    +       V V+EG  + L C+PP
Sbjct: 100  GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPP 159

Query: 221  PHSPEIIYSWVFNEFPSFVAEDSRRFISQ-ETGNLYISKVQTSDVGS-YICLVKNTVTNA 278
            P  P  +  W+ +     + +D R  +SQ   G+LY S V   D+ + Y C  +   T+ 
Sbjct: 160  PGLPSPVIFWMSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHT 216

Query: 279  ---------RVLS--PPTPLTLRNDGVM----GEYEPKIEVHFPFTVTAA----KGTTVK 319
                     +VL+  P    +LRN   M    G  E      +P    ++    +G  + 
Sbjct: 217  IQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLL 276

Query: 320  MECFALGNPVPTITWMKVNGYIPS-KARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKN 378
            +EC A G P P I W K  G +PS KA+       L I NV  +D+G Y C A N  G  
Sbjct: 277  LECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSI 336

Query: 379  SFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLS---PQSR 435
                 ++V   P+W+++  +  L  G   R  C+A G P+PT +W+ NG PL    P   
Sbjct: 337  RHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPN 396

Query: 436  VEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFAL--NQLKKTIIV 493
             E+    ++  +   S   +YQC   N++G + A+A + +L   P      NQL + I+ 
Sbjct: 397  REVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILY 456

Query: 494  TKDQEVVIECKPQGSPKPTISW-KKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCR 552
             + +   ++C   GSP PT+ W K G  +  +     +  +GSL I    K D+G Y C 
Sbjct: 457  NRTR---LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCV 513

Query: 553  GENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQ 612
              N+ G AE    L VK+PTRI   P+      G ++ L C+  HD SL +T  W    +
Sbjct: 514  ATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDE 573

Query: 613  PIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPG 672
            P+        +   R +     L I  +     G Y C   T  D    +A L V G P 
Sbjct: 574  PL--------YIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPD 625

Query: 673  PPGIVIVEEITESTATLSWSPAADNHSPISSYNLQ-ARSPFSLG-WQTVKTVPEIITGDM 730
             P  + + ++ E +  L+W P   N+SPI+ Y +Q     F  G W      P    G +
Sbjct: 626  RPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYP----GSV 681

Query: 731  ESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHEL 790
             SA+ + L+P+V Y+FRV+A N +G+  PS PS   RT+ A P++ P +V G   R++ +
Sbjct: 682  NSAV-LRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNM 740

Query: 791  VIAWEPVSEEFQNGEGFGYIVAFRPNGTR-GWKEKMVTSSEASKFIYRDESVPPLTPFEV 849
             I W P++     G    YIV +R   TR  W    V  S      Y     P   P+E+
Sbjct: 741  EITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSR-----YVVGQTPVYVPYEI 795

Query: 850  KVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESL--GRPQ 907
            +V   N+ G GP  + V+  S E  P AAPT+VK   ++ + I + W  +      G+ +
Sbjct: 796  RVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLR 855

Query: 908  GFEVGYWKDMEQEDTAETVKTRGNESFV------ILTGLEGNTLYHFTVRAYNGAGYGPP 961
             +   YW++          + R   SF       +++ L   + Y   +   NG G GP 
Sbjct: 856  EYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPR 915

Query: 962  SSEVSATTKKSPPSQAPSNLRWEQQGSQ-VSLGWEPVIPLANESEVVGYKVFY 1013
            S     TT +  PS AP   R  Q   + ++L W+   P      ++GY + Y
Sbjct: 916  SETKEFTTPEGVPS-APRRFRVRQPNLETINLEWDH--PEHPNGIMIGYTLKY 965



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 65/321 (20%), Positives = 121/321 (37%), Gaps = 55/321 (17%)

Query: 394 EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKN----GVPLSPQSRVEMVNGVLMIH--- 446
           +   D  +D    +  EC+A G P P++ W +N     +   P+  +   +G L+I    
Sbjct: 40  QSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 99

Query: 447 -NVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECK- 504
               +   G YQC A NK+G   ++     ++ +P +    L   ++V +   + ++C  
Sbjct: 100 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENL-DPVVVQEGAPLTLQCNP 158

Query: 505 PQGSPKPTISWKKGD-RAVRENKRIAILPDGSLRILNASKSD-EGKYVCRGENVF----- 557
           P G P P I W       + ++KR++   +G L   N    D +  Y C     F     
Sbjct: 159 PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQ 218

Query: 558 ---------------------GSAEIIASLSVKEPTRIELTPKRTE----LTVGESIVLN 592
                                   ++ ++  V E T   + P+ T     +  G  ++L 
Sbjct: 219 QKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLE 278

Query: 593 CKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSAD--LMIRNILLMHAGRYGC 650
           C A    + D+ +Y           ++GG   S +A+  + +  L I N+    +G Y C
Sbjct: 279 CIASGVPTPDIAWY-----------KKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFC 327

Query: 651 RVQTTADSVSDEAELLVRGPP 671
                  S+     + V+  P
Sbjct: 328 LASNKMGSIRHTISVRVKAAP 348



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 38/178 (21%), Positives = 76/178 (42%), Gaps = 21/178 (11%)

Query: 476 LASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDR--AVRENKRIAILPD 533
           L   PT      K  I+  +D  ++IEC+ +G+P P+  W +  R   + ++ R+++   
Sbjct: 31  LTQPPTITKQSAKDHIVDPRDN-ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR 89

Query: 534 GSLRILN-----ASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKR----TELT 584
               +++       +  EG+Y C   N FG+A  +++    + ++  L PK       + 
Sbjct: 90  SGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA--LSNRIRLQVSKSPLWPKENLDPVVVQ 147

Query: 585 VGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILL 642
            G  + L C         V F+ +   +PI  ++         +Q  + DL   N++L
Sbjct: 148 EGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKR-------VSQGHNGDLYFSNVML 198


>gi|81158224 neuronal cell adhesion molecule isoform B precursor
           [Homo sapiens]
          Length = 1183

 Score =  362 bits (929), Expect = 1e-99
 Identities = 273/942 (28%), Positives = 423/942 (44%), Gaps = 76/942 (8%)

Query: 103 QEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGT--FIIS 160
           Q P D I       + + + CE +G P PS+ W RNGT  D++ D   ++  GT   II+
Sbjct: 45  QSPKDYII---DPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIIN 101

Query: 161 NPSEAKDS---GHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMC 217
             SE K     G YQC A N  G+ +S    ++ +    ++      ++++ GQ +VL C
Sbjct: 102 IMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPC 161

Query: 218 SPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGS-YICLVKNTVT 276
            PP   P  I  W+ N F       S R      G+LY S V   D    YIC  +    
Sbjct: 162 RPPIGLPPPIIFWMDNSFQRL--PQSERVSQGLNGDLYFSNVLPEDTREDYICYAR--FN 217

Query: 277 NARVLSPPTPLTLR-------NDGVMGE------YEPKIEVHFPFTVTAA---------- 313
           + + +    P++++       ND +         Y  K     P T              
Sbjct: 218 HTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEEL 277

Query: 314 KGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKS-QAVLEIPNVQLDDAGIYECRAE 372
           +G  + +EC A G P P I W K +G +P    + K+ +  L+I +V   D+G Y+C A+
Sbjct: 278 RGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAK 337

Query: 373 NSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPL-- 430
           N+ G       ++V   P+W+    +  L  G      C+A G P+P   WL NGVP+  
Sbjct: 338 NALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEI 397

Query: 431 SPQSRVEMVNG-VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKK 489
           +P      ++G  ++  NV +  + +YQC A N+YG + A+A + +LA  P   L     
Sbjct: 398 APDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRI-LTPANT 456

Query: 490 TIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPD-GSLRILNASKSDEGK 548
              V  ++  +++C   GSP PTI W KG +    ++ I +L + G+L I  A K   G 
Sbjct: 457 LYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGT 516

Query: 549 YVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWT 608
           Y C   N  G A+    L +K+PT I   P+   +  G  +   CK  HD +L +T  W 
Sbjct: 517 YTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWL 576

Query: 609 LKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVR 668
              + +  +E        R       L++ ++    +G Y C   TT DSVS  A L V 
Sbjct: 577 KDNRELPSDE--------RFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVV 628

Query: 669 GPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQ----ARSPFSLGWQTVKTVPE 724
             P PP  + + +  + +  LSW+P  DN+SPI+ + ++       P     QT      
Sbjct: 629 DVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTE----- 683

Query: 725 IITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRS 784
            ++G   +A  + L+P+V Y FRV+A N IG   PS  S    T  + P   PT V G  
Sbjct: 684 -VSGTQTTAQ-LKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLG 741

Query: 785 GRRHELVIAWEPVSEEFQNGEGFGYIVAFR-PNGTRGWKEKMVTSSEASKFIYRDESVPP 843
                LVI W+P++    NG G  Y V++R  +G   W   +V  +  SK+I      P 
Sbjct: 742 SEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVV--ANVSKYIV--SGTPT 797

Query: 844 LTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHI--KE 901
             P+ +KV   N+ G  P   +V+  S E  P  AP +V+   V+ +   V W  +  K 
Sbjct: 798 FVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKS 857

Query: 902 SLGRPQGFEVGYWKDMEQED------TAETVKTRGNESFVILTGLEGNTLYHFTVRAYNG 955
             G  QG+ + YWK              + +  +G+++  +L GLE  + Y   VR  NG
Sbjct: 858 IRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNG 917

Query: 956 AGYGPPSSEVSATTKKSPPSQAPSNLRWEQQG-SQVSLGWEP 996
            G GP S +    T +  PS APS+L+        ++L W+P
Sbjct: 918 KGEGPASPDRVFNTPEGVPS-APSSLKIVNPTLDSLTLEWDP 958



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 35/130 (26%), Positives = 60/130 (46%), Gaps = 14/130 (10%)

Query: 476 LASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDR--AVRENKRIAILPD 533
           L   PT    Q  K  I+   + +VI+C+ +G P P+ SW +      + ++  + + P 
Sbjct: 36  LVQPPTIT-QQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPG 94

Query: 534 GSLRILN-----ASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKR----TELT 584
               I+N      +++ EG Y C   N  G+A  +++  V  P+R  L  K       L 
Sbjct: 95  TGTLIINIMSEGKAETYEGVYQCTARNERGAA--VSNNIVVRPSRSPLWTKEKLEPITLQ 152

Query: 585 VGESIVLNCK 594
            G+S+VL C+
Sbjct: 153 SGQSLVLPCR 162


>gi|237858677 neurofascin isoform 2 precursor [Homo sapiens]
          Length = 1189

 Score =  360 bits (923), Expect = 5e-99
 Identities = 280/968 (28%), Positives = 428/968 (44%), Gaps = 91/968 (9%)

Query: 106  DDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI--DGTFIISNPS 163
            D I+ P D+    + + CE +GNP PS+ W RN    ++  D R S+    GT +I   S
Sbjct: 44   DHIVDPRDN----ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 99

Query: 164  EAKDS---GHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPP 220
              +     G YQC A N  G+ LS    LQ +    +       V V+EG  + L C+PP
Sbjct: 100  GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPP 159

Query: 221  PHSPEIIYSWVFNEFPSFVAEDSRRFISQ-ETGNLYISKVQTSDVGS-YICLVKNTVTNA 278
            P  P  +  W+ +     + +D R  +SQ   G+LY S V   D+ + Y C  +   T+ 
Sbjct: 160  PGLPSPVIFWMSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHT 216

Query: 279  ---------RVLS--PPTPLTLRNDGVM----GEYEPKIEVHFPFTVTAA----KGTTVK 319
                     +VL+  P    +LRN   M    G  E      +P    ++    +G  + 
Sbjct: 217  IQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLL 276

Query: 320  MECFALGNPVPTITWMKVNGYIPS-KARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKN 378
            +EC A G P P I W K  G +PS KA+       L I NV  +D+G Y C A N  G  
Sbjct: 277  LECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSI 336

Query: 379  SFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLS---PQSR 435
                 ++V   P+W+++  +  L  G   R  C+A G P+PT +W+ NG PL    P   
Sbjct: 337  RHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPN 396

Query: 436  VEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFAL--NQLKKTIIV 493
             E+    ++  +   S   +YQC   N++G + A+A + +L   P      NQL + I+ 
Sbjct: 397  REVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILY 456

Query: 494  TKDQEVVIECKPQGSPKPTISW-KKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCR 552
             + +   ++C   GSP PT+ W K G  +  +     +  +GSL I    K D+G Y C 
Sbjct: 457  NRTR---LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCV 513

Query: 553  GENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQ 612
              N+ G AE    L VK+PTRI   P+      G ++ L C+  HD SL +T  W    +
Sbjct: 514  ATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDE 573

Query: 613  PIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLV----- 667
            P+        +   R +     L I  +     G Y C   T  D    +A L V     
Sbjct: 574  PL--------YIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQA 625

Query: 668  ----------RGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQ-ARSPFSLG- 715
                      +G P  P  + + ++ E +  L+W P   N+SPI+ Y +Q     F  G 
Sbjct: 626  TPTNRLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGV 685

Query: 716  WQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKT 775
            W      P    G + SA+ + L+P+V Y+FRV+A N +G+  PS PS   RT+ A P++
Sbjct: 686  WHDHSKYP----GSVNSAV-LRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPES 740

Query: 776  APTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTR-GWKEKMVTSSEASKF 834
             P +V G   R++ + I W P++     G    YIV +R   TR  W    V  S     
Sbjct: 741  NPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSR---- 796

Query: 835  IYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILV 894
             Y     P   P+E++V   N+ G GP  + V+  S E  P AAPT+VK   ++ + I +
Sbjct: 797  -YVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISL 855

Query: 895  AWKHIKESL--GRPQGFEVGYWKDMEQEDTAETVKTRGNESFV------ILTGLEGNTLY 946
             W  +      G+ + +   YW++          + R   SF       +++ L   + Y
Sbjct: 856  QWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNY 915

Query: 947  HFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQ-VSLGWEPVIPLANESE 1005
               +   NG G GP S     TT +  PS AP   R  Q   + ++L W+   P      
Sbjct: 916  KLEMVVVNGRGDGPRSETKEFTTPEGVPS-APRRFRVRQPNLETINLEWDH--PEHPNGI 972

Query: 1006 VVGYKVFY 1013
            ++GY + Y
Sbjct: 973  MIGYTLKY 980



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 65/321 (20%), Positives = 121/321 (37%), Gaps = 55/321 (17%)

Query: 394 EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKN----GVPLSPQSRVEMVNGVLMIH--- 446
           +   D  +D    +  EC+A G P P++ W +N     +   P+  +   +G L+I    
Sbjct: 40  QSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 99

Query: 447 -NVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECK- 504
               +   G YQC A NK+G   ++     ++ +P +    L   ++V +   + ++C  
Sbjct: 100 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENL-DPVVVQEGAPLTLQCNP 158

Query: 505 PQGSPKPTISWKKGD-RAVRENKRIAILPDGSLRILNASKSD-EGKYVCRGENVF----- 557
           P G P P I W       + ++KR++   +G L   N    D +  Y C     F     
Sbjct: 159 PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQ 218

Query: 558 ---------------------GSAEIIASLSVKEPTRIELTPKRTE----LTVGESIVLN 592
                                   ++ ++  V E T   + P+ T     +  G  ++L 
Sbjct: 219 QKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLE 278

Query: 593 CKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSAD--LMIRNILLMHAGRYGC 650
           C A    + D+ +Y           ++GG   S +A+  + +  L I N+    +G Y C
Sbjct: 279 CIASGVPTPDIAWY-----------KKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFC 327

Query: 651 RVQTTADSVSDEAELLVRGPP 671
                  S+     + V+  P
Sbjct: 328 LASNKMGSIRHTISVRVKAAP 348



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 38/178 (21%), Positives = 76/178 (42%), Gaps = 21/178 (11%)

Query: 476 LASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDR--AVRENKRIAILPD 533
           L   PT      K  I+  +D  ++IEC+ +G+P P+  W +  R   + ++ R+++   
Sbjct: 31  LTQPPTITKQSAKDHIVDPRDN-ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR 89

Query: 534 GSLRILN-----ASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKR----TELT 584
               +++       +  EG+Y C   N FG+A  +++    + ++  L PK       + 
Sbjct: 90  SGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA--LSNRIRLQVSKSPLWPKENLDPVVVQ 147

Query: 585 VGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILL 642
            G  + L C         V F+ +   +PI  ++         +Q  + DL   N++L
Sbjct: 148 EGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKR-------VSQGHNGDLYFSNVML 198



 Score = 31.2 bits (69), Expect = 5.6
 Identities = 27/111 (24%), Positives = 42/111 (37%), Gaps = 2/111 (1%)

Query: 669  GPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITG 728
            G P  P    V +    T  L W      +  +  Y L+  + F+ G +  K + E  + 
Sbjct: 941  GVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVA-FN-GTKVGKQIVENFSP 998

Query: 729  DMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTN 779
            +         +P   Y F + A   +G+G+  T       NEA P  A TN
Sbjct: 999  NQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAAYTN 1049


>gi|81158226 neuronal cell adhesion molecule isoform A precursor
           [Homo sapiens]
          Length = 1304

 Score =  358 bits (918), Expect = 2e-98
 Identities = 274/952 (28%), Positives = 424/952 (44%), Gaps = 86/952 (9%)

Query: 103 QEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGT--FIIS 160
           Q P D I       + + + CE +G P PS+ W RNGT  D++ D   ++  GT   II+
Sbjct: 51  QSPKDYII---DPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIIN 107

Query: 161 NPSEAKDS---GHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMC 217
             SE K     G YQC A N  G+ +S    ++ +    ++      ++++ GQ +VL C
Sbjct: 108 IMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPC 167

Query: 218 SPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGS-YICLVKNTVT 276
            PP   P  I  W+ N F       S R      G+LY S V   D    YIC  +    
Sbjct: 168 RPPIGLPPPIIFWMDNSFQRL--PQSERVSQGLNGDLYFSNVLPEDTREDYICYAR--FN 223

Query: 277 NARVLSPPTPLTLR-------NDGVMGE------YEPKIEVHFPFTVTAA---------- 313
           + + +    P++++       ND +         Y  K     P T              
Sbjct: 224 HTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEEL 283

Query: 314 KGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKS-QAVLEIPNVQLDDAGIYECRAE 372
           +G  + +EC A G P P I W K +G +P    + K+ +  L+I +V   D+G Y+C A+
Sbjct: 284 RGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAK 343

Query: 373 NSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPL-- 430
           N+ G       ++V   P+W+    +  L  G      C+A G P+P   WL NGVP+  
Sbjct: 344 NALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEI 403

Query: 431 SPQSRVEMVNG-VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKK 489
           +P      ++G  ++  NV +  + +YQC A N+YG + A+A + +LA  P   L     
Sbjct: 404 APDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRI-LTPANT 462

Query: 490 TIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPD-GSLRILNASKSDEGK 548
              V  ++  +++C   GSP PTI W KG +    ++ I +L + G+L I  A K   G 
Sbjct: 463 LYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGT 522

Query: 549 YVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWT 608
           Y C   N  G A+    L +K+PT I   P+   +  G  +   CK  HD +L +T  W 
Sbjct: 523 YTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWL 582

Query: 609 LKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVR 668
              + +  +E        R       L++ ++    +G Y C   TT DSVS  A L V 
Sbjct: 583 KDNRELPSDE--------RFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVV 634

Query: 669 GP----------PGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQ----ARSPFSL 714
            P          P PP  + + +  + +  LSW+P  DN+SPI+ + ++       P   
Sbjct: 635 APTPTPAPVYDVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLW 694

Query: 715 GWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPK 774
             QT       ++G   +A  + L+P+V Y FRV+A N IG   PS  S    T  + P 
Sbjct: 695 HHQTE------VSGTQTTAQ-LKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPD 747

Query: 775 TAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFR-PNGTRGWKEKMVTSSEASK 833
             PT V G       LVI W+P++    NG G  Y V++R  +G   W   +V  +  SK
Sbjct: 748 KNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVV--ANVSK 805

Query: 834 FIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEIL 893
           +I      P   P+ +KV   N+ G  P   +V+  S E  P  AP +V+   V+ +   
Sbjct: 806 YIV--SGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAE 863

Query: 894 VAWKHI--KESLGRPQGFEVGYWKDMEQED------TAETVKTRGNESFVILTGLEGNTL 945
           V W  +  K   G  QG+ + YWK              + +  +G+++  +L GLE  + 
Sbjct: 864 VHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSH 923

Query: 946 YHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQG-SQVSLGWEP 996
           Y   VR  NG G GP S +    T +  PS APS+L+        ++L W+P
Sbjct: 924 YTLNVRVVNGKGEGPASPDRVFNTPEGVPS-APSSLKIVNPTLDSLTLEWDP 974



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 36/133 (27%), Positives = 62/133 (46%), Gaps = 14/133 (10%)

Query: 473 LKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDR--AVRENKRIAI 530
           L+ L   PT    Q  K  I+   + +VI+C+ +G P P+ SW +      + ++  + +
Sbjct: 39  LEDLVQPPTIT-QQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTM 97

Query: 531 LPDGSLRILN-----ASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKR----T 581
            P     I+N      +++ EG Y C   N  G+A  +++  V  P+R  L  K      
Sbjct: 98  KPGTGTLIINIMSEGKAETYEGVYQCTARNERGAA--VSNNIVVRPSRSPLWTKEKLEPI 155

Query: 582 ELTVGESIVLNCK 594
            L  G+S+VL C+
Sbjct: 156 TLQSGQSLVLPCR 168



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 42/198 (21%), Positives = 80/198 (40%), Gaps = 12/198 (6%)

Query: 669  GPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITG 728
            G P  P  + +   T  + TL W P +  +  ++ Y L+ + P +   +    V   I  
Sbjct: 950  GVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGILTEYTLKYQ-PINSTHELGPLVDLKIPA 1008

Query: 729  DMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEA---VPKTAPTNVSGRSG 785
            +       +LN    Y+F   A    G+G   T   +   +EA    P      V   + 
Sbjct: 1009 NKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEEAVTTVDEAGILPPDVGAGKVQAVNP 1068

Query: 786  RRHELVIA----WEPVSEEFQNGEGFGYIVAFRPNGTR-GWKEKMVTSSEASKFIYRDES 840
            R   L  A    +  +S E++  E   + V +   G++  W++++V  S +    +  + 
Sbjct: 1069 RISNLTAAAAETYANISWEYEGPEHVNFYVEYGVAGSKEEWRKEIVNGSRS---FFGLKG 1125

Query: 841  VPPLTPFEVKVGVYNNKG 858
            + P T ++V+VG   + G
Sbjct: 1126 LMPGTAYKVRVGAVGDSG 1143


>gi|27894376 cell adhesion molecule with homology to L1CAM precursor
            [Homo sapiens]
          Length = 1224

 Score =  348 bits (893), Expect = 2e-95
 Identities = 268/1001 (26%), Positives = 436/1001 (43%), Gaps = 86/1001 (8%)

Query: 67   PSWLGAAQNYYSPINLYHSSDAFKQDESVDYGPVFVQEPD-DIIFPTDSDEKKVALNCEV 125
            P  LG     Y    L   S A +   SV   P  +++    + FP D   +   + CE 
Sbjct: 3    PLLLGRGLIVYLMFLLLKFSKAIEIPSSVQQVPTIIKQSKVQVAFPFD---EYFQIECEA 59

Query: 126  RGNPVPSYRWLRNGTEIDLESDYRY--SLIDGTFIISNPSEAKD-SGHYQCLATNTVGSI 182
            +GNP P++ W ++G      +D+R   S   GTF I N        G Y+C A+N +G  
Sbjct: 60   KGNPEPTFSWTKDGNPFYF-TDHRIIPSNNSGTFRIPNEGHISHFQGKYRCFASNKLGIA 118

Query: 183  LSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAED 242
            +S E       +  F       + V EG  +VL C+PP   P +   W+  E    + +D
Sbjct: 119  MSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIEL-EHIEQD 177

Query: 243  SRRFISQETGNLYISKVQTSDVGSYIC------------------LVKNTVTNARVLSPP 284
             R ++SQ+ G+LY + V+  D  +  C                  L  N++ +A   S  
Sbjct: 178  ERVYMSQK-GDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSS 236

Query: 285  TPLTLRNDGVMGEYEPKI-----EVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNG 339
            T +  + + +  + +PK+     E     ++T  KG  + +ECFA G P P + W K+ G
Sbjct: 237  TEIGSKANSIK-QRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGG 295

Query: 340  YIPSKARLRKSQA-VLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLND 398
             +P     +++    L+I NV   D G Y C A N  G  +    + V   P W +K   
Sbjct: 296  DLPKGRETKENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQS 355

Query: 399  TQLDSGSPLRWECKATGKPRPTYRWLKNGVPLS--PQSRVEMVNGVLMIHNVNQSDAGMY 456
                +GS     C+A G+P+PT +W  NG P+   P +   +    +   N+  +   +Y
Sbjct: 356  AVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNHTAVY 415

Query: 457  QCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQE---------VVIECKPQG 507
            QC A N +G I A+A + ++   P          +I TKD E           + C+   
Sbjct: 416  QCEASNVHGTILANANIDVVDVRP----------LIQTKDGENYATVVGYSAFLHCEFFA 465

Query: 508  SPKPTISWKKGDRAVR-ENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASL 566
            SP+  +SW+K +     E +R  I  +G+L+I   ++ D G Y C  EN  G   + A+L
Sbjct: 466  SPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANL 525

Query: 567  SVKEPTRIELTPKRTELTVGESIVLNCKAIHDASL--DVTFYWTLKGQPIDFEEEGGHFE 624
             ++  T++ ++PK   +     + L+C++  D+ L   +   W+  G+   FE  G   E
Sbjct: 526  DIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEA--FEINGT--E 581

Query: 625  SIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITE 684
              R     A+L I N+ L   G Y C   T  DS +D  ++ V   P PP  + + E   
Sbjct: 582  DGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLDVPDPPENLHLSERQN 641

Query: 685  STATLSWSPAADNHSPISSY--NLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWV 742
             +  L+W   AD++S IS Y    +        W+ +  V        ++ + + L P+V
Sbjct: 642  RSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWEELTRVQ-----GKKTTVILPLAPFV 696

Query: 743  EYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQ 802
             Y+FRV+A N +G   PS PS    T  A P   P N+  ++ +  E++I WEP+    Q
Sbjct: 697  RYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQ 756

Query: 803  NGEGFGYIVAFRPNGTR-GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGP 861
            NG G  Y V ++P G    W+E+ VT+        R  +     P++VKV   N  G GP
Sbjct: 757  NGPGLEYRVTWKPQGAPVEWEEETVTN-----HTLRVMTPAVYAPYDVKVQAINQLGSGP 811

Query: 862  FSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESL--GRPQGFEVGYWKDMEQ 919
              Q V + S E  P  AP       ++ + + V W  + +    GR +G+++ +WK    
Sbjct: 812  DPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSL 871

Query: 920  ED------TAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSP 973
             D          ++  G  +  ++  L+  + +H TV AYN  G GP S      T +  
Sbjct: 872  LDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGV 931

Query: 974  PSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYR 1014
            P Q       +      +L W   +P      + GY + Y+
Sbjct: 932  PEQPTFLKVIKVDKDTATLSWG--LPKKLNGNLTGYLLQYQ 970



 Score =  120 bits (302), Expect = 5e-27
 Identities = 186/810 (22%), Positives = 309/810 (38%), Gaps = 86/810 (10%)

Query: 201  TRSAVSVREGQGVVLMC-SPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKV 259
            + S++++ +G+ ++L C +    +P++ ++ +  + P       R         L I  V
Sbjct: 262  SESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPK-----GRETKENYGKTLKIENV 316

Query: 260  QTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVK 319
               D G+Y C   N +  A            +D  +   EP      P +   + G+   
Sbjct: 317  SYQDKGNYRCTASNFLGTAT-----------HDFHVIVEEPPRWTKKPQSAVYSTGSNGI 365

Query: 320  MECFALGNPVPTITWMKVNGYIPSKARLRKSQAV----LEIPNVQLDDAGIYECRAENSR 375
            + C A G P PTI W +VNG  P          V    +   N+Q +   +Y+C A N  
Sbjct: 366  LLCEAEGEPQPTIKW-RVNGS-PVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVH 423

Query: 376  GKNSFRGQLQVYTYPHWVEKLNDTQLDS--GSPLRWECKATGKPRPTYRWLK--NGVPLS 431
            G       + V      ++  +     +  G      C+    P     W K     PL 
Sbjct: 424  GTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLE 483

Query: 432  PQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTI 491
             +      NG L I+   + DAG Y C  EN  G    +A L I  +A    ++     I
Sbjct: 484  GRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDI-RNATKLRVSPKNPRI 542

Query: 492  IVTKDQEVVIECKPQGSPKPTI--SWKKGDRAVR----ENKRIAILPDGSLRILNASKSD 545
                  E+  E K     K ++  SW K   A      E+ RI I+   +L I N +  D
Sbjct: 543  PKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRI-IIDGANLTISNVTLED 601

Query: 546  EGKYVCRGENVFGSAEIIASLSVKE----PTRIELTPKRTELTVGESIVLNCKAIHDASL 601
            +G Y C       SA  I  ++V +    P  + L+ ++       S+ L  +A  D + 
Sbjct: 602  QGIYCCSAHTALDSAADITQVTVLDVPDPPENLHLSERQNR-----SVRLTWEAGADHNS 656

Query: 602  DVTFYWTLKGQPIDFE---EEGGHFESI-RAQASSADLMIRNILLMHAGRYGCRV----- 652
            +++ Y       ++FE   EE G +E + R Q     +++    L    RY  RV     
Sbjct: 657  NISEYI------VEFEGNKEEPGRWEELTRVQGKKTTVILP---LAPFVRYQFRVIAVNE 707

Query: 653  --QTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSP--AADNHSPISSYNLQA 708
              ++     SD  E     P   P  + V+        + W P  + + + P     L+ 
Sbjct: 708  VGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGP----GLEY 763

Query: 709  RSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRT 768
            R  +      V+   E +T      M   +  +  Y+ +V A N +G+G P   S  + +
Sbjct: 764  RVTWKPQGAPVEWEEETVTNHTLRVMTPAV--YAPYDVKVQAINQLGSG-PDPQSVTLYS 820

Query: 769  NEAVPKTAPTNVSGRSGRRHELV-IAWEPVSEEFQNGEGFGYIVAFRP-----NGTRGWK 822
             E  P TAP  + G       LV + W  V ++  +G   GY + +       +G    K
Sbjct: 821  GEDYPDTAPV-IHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPK 879

Query: 823  EKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDV 882
            E  +      +      S+   + F + V  YN+KG GP S+  +  + EG P   PT +
Sbjct: 880  EVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQ-PTFL 938

Query: 883  KATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAE----TVKTRGNESFVILT 938
            K   V      ++W   K+  G   G+ + Y    +  +  E     + T    S+  L+
Sbjct: 939  KVIKVDKDTATLSWGLPKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPSKPSWH-LS 997

Query: 939  GLEGNTLYHFTVRAYNGAGYGPPSSEVSAT 968
             L   T Y F +RA    G G P +E S+T
Sbjct: 998  NLNATTKYKFYLRACTSQGCGKPITEESST 1027



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 179/870 (20%), Positives = 321/870 (36%), Gaps = 131/870 (15%)

Query: 299  EPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKV-NGYIPSKARLRKSQ--AVLE 355
            + K++V FPF          ++EC A GNP PT +W K  N +  +  R+  S       
Sbjct: 40   QSKVQVAFPFD------EYFQIECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFR 93

Query: 356  IPNVQLDD--AGIYECRAENSRG-KNSFRGQLQVYTYPHWV-EKLNDTQLDSGSPLRWEC 411
            IPN        G Y C A N  G   S   +  V + P +  EK++  +++ G P+   C
Sbjct: 94   IPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPC 153

Query: 412  KAT-GKPRPTYRWLKNGVP-LSPQSRVEMVN-GVLMIHNVNQSDA-GMYQCLAE-NKYGA 466
                G P     W+   +  +    RV M   G L   NV + D+   Y C A   +   
Sbjct: 154  NPPKGLPPLHIYWMNIELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRT 213

Query: 467  IYASAELKILASAPTFA------------LNQLKK----------------TIIVTKDQE 498
            I     +K+  ++   A             N +K+                +I + K + 
Sbjct: 214  IVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSITILKGEI 273

Query: 499  VVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFG 558
            +++EC  +G P P + W K    + + +        +L+I N S  D+G Y C   N  G
Sbjct: 274  LLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCTASNFLG 333

Query: 559  SAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEE 618
            +A     + V+EP R    P+    + G + +L C+A  +     T  W + G P+D   
Sbjct: 334  TATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEA--EGEPQPTIKWRVNGSPVDNHP 391

Query: 619  EGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVI 678
              G     R      ++   N+   H   Y C       ++   A +          +V 
Sbjct: 392  FAGDVVFPR------EISFTNLQPNHTAVYQCEASNVHGTILANANI---------DVVD 436

Query: 679  VEEITESTATLSWSPAADNHSPISSYNLQARSPFS------LGWQTVKTVPEII------ 726
            V  + ++          +N++ +  Y+      F       + WQ V+ V  +       
Sbjct: 437  VRPLIQTKD-------GENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHI 489

Query: 727  --TGDMESAMAVDLNP-----WVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTN 779
               G ++     + +      WVE      A         +T  R+   N  +PK     
Sbjct: 490  YENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLE 549

Query: 780  VSGRSG----RRHELVIAWEPVSEEFQ-NGEGFGYIVAFRPNGTRG---WKEKMVTSSEA 831
            +   S      +H L ++W    E F+ NG   G I+    N T      +++ +    A
Sbjct: 550  LHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSA 609

Query: 832  SKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSE 891
               +     +  +T  +V     N       ++ V +    G    +         ++SE
Sbjct: 610  HTALDSAADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNS---------NISE 660

Query: 892  ILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVR 951
             +V ++  KE  GR        W+++         + +G ++ VIL  L     Y F V 
Sbjct: 661  YIVEFEGNKEEPGR--------WEEL--------TRVQGKKTTVILP-LAPFVRYQFRVI 703

Query: 952  AYNGAGYGPPSSEVSA-TTKKSPPSQAPSNLRWE-QQGSQVSLGWEPVIPLANESEVVGY 1009
            A N  G   PS       T  + P + P N+R +  Q  ++ + WEP+  +      + Y
Sbjct: 704  AVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEY 763

Query: 1010 KVFYRQEG---HSNSQVIETQKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQIRVPSYS 1066
            +V ++ +G       + +    L+ + P   A  Y ++V+A ++ G G     + +  YS
Sbjct: 764  RVTWKPQGAPVEWEEETVTNHTLRVMTPAVYA-PYDVKVQAINQLGSGPDPQSVTL--YS 820

Query: 1067 GGKITSAQSTLHSLSTSSSSVTLLLALMIP 1096
            G         +H +   +S++  +    +P
Sbjct: 821  GEDYPDTAPVIHGVDVINSTLVKVTWSTVP 850


>gi|237858675 neurofascin isoform 1 precursor [Homo sapiens]
          Length = 1240

 Score =  346 bits (888), Expect = 6e-95
 Identities = 265/918 (28%), Positives = 405/918 (44%), Gaps = 77/918 (8%)

Query: 106 DDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI--DGTFIISNPS 163
           D I+ P D+    + + CE +GNP PS+ W RN    ++  D R S+    GT +I   S
Sbjct: 50  DHIVDPRDN----ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 105

Query: 164 EAKDS---GHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPP 220
             +     G YQC A N  G+ LS    LQ +    +       V V+EG  + L C+PP
Sbjct: 106 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPP 165

Query: 221 PHSPEIIYSWVFNEFPSFVAEDSRRFISQ-ETGNLYISKVQTSDVGS-YICLVKNTVTNA 278
           P  P  +  W+ +     + +D R  +SQ   G+LY S V   D+ + Y C  +   T+ 
Sbjct: 166 PGLPSPVIFWMSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHT 222

Query: 279 RVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAA----KGTTVKMECFALGNPVPTITW 334
             +    P TL+     G  E      +P    ++    +G  + +EC A G P P I W
Sbjct: 223 --IQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAW 280

Query: 335 MKVNGYIPS-KARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWV 393
            K  G +PS KA+       L I NV  +D+G Y C A N  G       ++V   P+W+
Sbjct: 281 YKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWL 340

Query: 394 EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLS---PQSRVEMVNGVLMIHNVNQ 450
           ++  +  L  G   R  C+A G P+PT +W+ NG PL    P    E+    ++  +   
Sbjct: 341 DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQI 400

Query: 451 SDAGMYQCLAENKYGAIYASAELKILASAPTFAL--NQLKKTIIVTKDQEVVIECKPQGS 508
           S   +YQC   N++G + A+A + +L   P      NQL + I+  + +   ++C   GS
Sbjct: 401 SSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR---LDCPFFGS 457

Query: 509 PKPTISW-KKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLS 567
           P PT+ W K G  +  +     +  +GSL I    K D+G Y C   N+ G AE    L 
Sbjct: 458 PIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLE 517

Query: 568 VKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIR 627
           VK+PTRI   P+      G ++ L C+  HD SL +T  W    +P+        +   R
Sbjct: 518 VKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL--------YIGNR 569

Query: 628 AQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLV---------------RGPPG 672
            +     L I  +     G Y C   T  D    +A L V               +G P 
Sbjct: 570 MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPKGRPD 629

Query: 673 PPGIVIVEEITESTATLSWSPAADNHSPISSYNLQ-ARSPFSLG-WQTVKTVPEIITGDM 730
            P  + + ++ E +  L+W P   N+SPI+ Y +Q     F  G W      P    G +
Sbjct: 630 RPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYP----GSV 685

Query: 731 ESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHEL 790
            SA+ + L+P+V Y+FRV+A N +G+  PS PS   RT+ A P++ P +V G   R++ +
Sbjct: 686 NSAV-LRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNM 744

Query: 791 VIAWEPVSEEFQNGEGFGYIVAFRPNGTR-GWKEKMVTSSEASKFIYRDESVPPLTPFEV 849
            I W P++     G    YIV +R   TR  W    V  S      Y     P   P+E+
Sbjct: 745 EITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSR-----YVVGQTPVYVPYEI 799

Query: 850 KVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGF 909
           +V   N+ G GP  + V+  S E  PS AP   +    ++  I + W H +     P G 
Sbjct: 800 RVQAENDFGKGPEPESVIGYSGEDLPS-APRRFRVRQPNLETINLEWDHPE----HPNGI 854

Query: 910 EVGYWKDMEQEDTAETVKT-----RGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSE 964
            +GY       +  +  K        N++   +   +  + Y FT+ A    G G   +E
Sbjct: 855 MIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTE 914

Query: 965 VS-ATTKKSPPSQAPSNL 981
            S A   ++ P+ AP  L
Sbjct: 915 ESPAPPNEATPTAAPPTL 932



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 66/305 (21%), Positives = 124/305 (40%), Gaps = 40/305 (13%)

Query: 394 EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKN----GVPLSPQSRVEMVNGVLMIH--- 446
           +   D  +D    +  EC+A G P P++ W +N     +   P+  +   +G L+I    
Sbjct: 46  QSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 105

Query: 447 -NVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECK- 504
               +   G YQC A NK+G   ++     ++ +P +    L   ++V +   + ++C  
Sbjct: 106 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENL-DPVVVQEGAPLTLQCNP 164

Query: 505 PQGSPKPTISWKKGD-RAVRENKRIAILPDGSLRILNASKSD-EGKYVCRG--------- 553
           P G P P I W       + ++KR++   +G L   N    D +  Y C           
Sbjct: 165 PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQ 224

Query: 554 -ENVFGSAEIIASLSVKEPTRIELTPKRTE----LTVGESIVLNCKAIHDASLDVTFYWT 608
            +N F + +++ +  V E T   + P+ T     +  G  ++L C A    + D+ +Y  
Sbjct: 225 QKNPF-TLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWY-- 281

Query: 609 LKGQPIDFEEEGGHFESIRAQASSAD--LMIRNILLMHAGRYGCRVQTTADSVSDEAELL 666
                    ++GG   S +A+  + +  L I N+    +G Y C       S+     + 
Sbjct: 282 ---------KKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR 332

Query: 667 VRGPP 671
           V+  P
Sbjct: 333 VKAAP 337



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 38/178 (21%), Positives = 76/178 (42%), Gaps = 21/178 (11%)

Query: 476 LASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDR--AVRENKRIAILPD 533
           L   PT      K  I+  +D  ++IEC+ +G+P P+  W +  R   + ++ R+++   
Sbjct: 37  LTQPPTITKQSAKDHIVDPRDN-ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR 95

Query: 534 GSLRILN-----ASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKR----TELT 584
               +++       +  EG+Y C   N FG+A  +++    + ++  L PK       + 
Sbjct: 96  SGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA--LSNRIRLQVSKSPLWPKENLDPVVVQ 153

Query: 585 VGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILL 642
            G  + L C         V F+ +   +PI  ++         +Q  + DL   N++L
Sbjct: 154 EGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKR-------VSQGHNGDLYFSNVML 204


>gi|222352127 sidekick 2 [Homo sapiens]
          Length = 2172

 Score =  274 bits (701), Expect = 3e-73
 Identities = 261/990 (26%), Positives = 409/990 (41%), Gaps = 58/990 (5%)

Query: 96   DYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLES-DYRYSLID 154
            D  P F  EP  +      +  ++ L C   G+    ++WL N  E+   S +YRY +  
Sbjct: 23   DVSPYFKTEP--VRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYMITS 80

Query: 155  GTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVV 214
                     +   +G Y+C+  N +G++L R+  +Q AY+G+F    +   SV  G+  V
Sbjct: 81   --------LDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQ-SVSHGEAAV 131

Query: 215  LMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNT 274
            +        P+   +W F +    +   SR  I+ E   + +S V   D G Y     N 
Sbjct: 132  IRAPRIASFPQPQVTW-FRDGRK-IPPSSRIAITLENTLVILSTV-APDAGRYYVQAVND 188

Query: 275  VTNARVLSPPTPLTLRNDGVMGE-YEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPT-- 331
                   S P  LT+ N G   +   P I +    T   A  + V +EC A   P+    
Sbjct: 189  KNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLH 248

Query: 332  ITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRA--ENSRGKNSFRGQ-LQVYT 388
            I W K +G + S   +      L IPN    DAG YEC A   +S   +  RG  L V  
Sbjct: 249  IIWKK-DGVLLSGG-ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLE 306

Query: 389  YPHWV-EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNG--VPLSPQSRVEMVN-GVLM 444
             P +V E       +    +   C+A G P P+  W K+   V +   +R    N G L 
Sbjct: 307  PPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQ 366

Query: 445  IHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECK 504
            I  +   D GM+QC A N  G +  S  L + + AP      L  T+I      VV+ C+
Sbjct: 367  ISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVI--DGMSVVLACE 424

Query: 505  PQGSPKPTISWKKGDRAVRENK----RIAILPDGSLRILNASKSDEGKYVCRGENVFGSA 560
              G+P+P I+W+KG+R +        R   L  GSL I     SD G Y C   N  G  
Sbjct: 425  TSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVD 484

Query: 561  EIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEG 620
            E  A L V   TRI   P+   +  G    + C   HD  + + + W   G  +  E   
Sbjct: 485  EASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESH- 543

Query: 621  GHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPG--IVI 678
                 IR   + + L I        G Y CRV +   + S  A L VR  P  P   +  
Sbjct: 544  ---PRIRLDRNGS-LHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVAT 599

Query: 679  VEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDL 738
            +  +      L+W+   D +SP+  Y L+  S  +  W  +      +     S     L
Sbjct: 600  LSTVERRAINLTWTKPFDGNSPLIRYILEM-SENNAPWTVLLAS---VDPKATSVTVKGL 655

Query: 739  NPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVS 798
             P   Y+FR+ A N +G G  S  +  +   E  P   P NV         ++I W+P  
Sbjct: 656  VPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPP 715

Query: 799  EEFQNGEGFGYIVAFRPNGTR-GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNK 857
            E  QNG   GYI+ +   G   G++ K +T ++ +  +  D  +   T +E++V  YN+ 
Sbjct: 716  ESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLII--WTNYEIEVAAYNSA 773

Query: 858  GDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESL--GRPQGFEVGYWK 915
            G G +S  V   + +G P+  P +V A + + + I   W         G  QG+++  W+
Sbjct: 774  GLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWE 833

Query: 916  -DMEQEDTAETVKTRGNESFVI--LTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKS 972
             + E+E T  T +    +S  +  ++GL+  T Y  +V  +   G GP S+     T + 
Sbjct: 834  PEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHED 893

Query: 973  PPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQV---IETQKL 1029
             P         E   + + + W+   P      + GY++ + +   +N++V   +    L
Sbjct: 894  VPGPVGHLSFSEILDTSLKVSWQE--PGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTL 951

Query: 1030 Q-AVVPLPDAGVYIIEVRAYSEGGDGTASS 1058
            +  V  L     Y IEV A +  G G  S+
Sbjct: 952  EYRVTGLTALTTYTIEVAAMTSKGQGQVSA 981



 Score =  142 bits (357), Expect = 2e-33
 Identities = 114/384 (29%), Positives = 185/384 (48%), Gaps = 38/384 (9%)

Query: 661  DEAELLV-----RGPPGPPGIVIV--EEITESTATLSWSPAADNHSPISSYNLQARSPFS 713
            + AE LV     R  P PP   +V  E++   +  LSW P +D  SP+  Y +Q R   S
Sbjct: 1385 EAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPS 1444

Query: 714  LGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVP 773
              W         ++ +  S +   L P+  Y+FRV ATN IG  + S  S  + T +A P
Sbjct: 1445 GRWALHSAS---VSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAP 1501

Query: 774  KTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRP---NGTRGWKEKMVTSSE 830
              APT +S        ++I W+P +E+  NG   G+ + +R     G RG+  + + +  
Sbjct: 1502 DEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPG 1561

Query: 831  A------SKFIYRDESVPPLTP-----------FEVKVGVYNNKGDGPFSQIVVICSAEG 873
            A      S +  R+ S P LT            +E+++ VYN  G+GP S    +   E 
Sbjct: 1562 ATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEA 1621

Query: 874  EPSAAPTDVKATSVSVSEILVAWK--HIKESLGRPQGFEVGYWKDMEQEDTAETVKTRG- 930
             P+AAP +V     + +++ V W+   +    G  QG+++ +W + ++ +  E VKT   
Sbjct: 1622 VPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFW-EAQRGNLTERVKTLFL 1680

Query: 931  NESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRW-EQQGSQ 989
             E+ V L  L G T Y  +V A+N AG GP S+     T+++ PS APS++++ E   + 
Sbjct: 1681 AENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPS-APSSVKFSELTTTS 1739

Query: 990  VSLGWEPVIPLANESEVVGYKVFY 1013
            V++ WE   P      + GY++ Y
Sbjct: 1740 VNVSWE--APQFPNGILEGYRLVY 1761



 Score =  139 bits (351), Expect = 1e-32
 Identities = 118/408 (28%), Positives = 180/408 (44%), Gaps = 24/408 (5%)

Query: 671  PGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITG-D 729
            PGPP  + +  I   + TL + P  D  + IS + ++A+       +    + ++    D
Sbjct: 993  PGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPD 1052

Query: 730  MESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHE 789
              S    DLNP+  Y FR+   N +GT  PS PSR I+T +A P  AP NVS R+     
Sbjct: 1053 ARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETS 1112

Query: 790  LVIAWEPVSEEFQNG--EGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPF 847
            L + W P+ E   NG  E  GY + +  +   G     V      +  Y  E +   T +
Sbjct: 1113 LWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVER-DYTIEDLEEWTEY 1171

Query: 848  EVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKES--LGR 905
             V+V  +N  G GP+SQ VV  + E  PS+ PT+V A + + S +LV W  + E+   G 
Sbjct: 1172 RVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGL 1231

Query: 906  PQGFEVGYWKDMEQEDTAETVKTRGNES-FVILTGLEGNTLYHFTVRAYNGAGYGPPS-S 963
              G++V Y K+ + +         GN S    LTGL    LY   V A+   G G PS  
Sbjct: 1232 VLGYKVMY-KEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHP 1290

Query: 964  EVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQV 1023
             +   T    P      L  E + + V L W+P  P A    ++ Y++ +R     N+  
Sbjct: 1291 PILERTLDDVPGPPMGILFPEVRTTSVRLIWQP--PAAPNGIILAYQITHR----LNTTT 1344

Query: 1024 IETQKLQAVVP---------LPDAGVYIIEVRAYSEGGDGTASSQIRV 1062
              T  ++ + P         L    VY+  + A +  G G A+  + V
Sbjct: 1345 ANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVV 1392



 Score =  138 bits (347), Expect = 3e-32
 Identities = 235/1057 (22%), Positives = 403/1057 (38%), Gaps = 115/1057 (10%)

Query: 98   GPVFVQEPDDIIFPTDSD----EKKVALNCEVRGNPVPSYR--WLRNGTEIDLE-SDYRY 150
            GP     P  II P ++       +V L C     P+      W ++G  +    SD+  
Sbjct: 208  GPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISDHNR 267

Query: 151  SLIDGTFIISNPSEAKDSGHYQCLATNTVGSILS--REATLQFAYLGNFSGRTRSAVSVR 208
             L      I NP+   D+G+Y+C A     S+ S  R A L       F       ++  
Sbjct: 268  RLT-----IPNPT-GSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAE 321

Query: 209  EGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYI 268
              + V + C      P  I +W + +      E   RF  +  G L IS +   D G + 
Sbjct: 322  MEKVVDIPCQAKGVPPPSI-TW-YKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQ 379

Query: 269  CLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNP 328
            C  +N     +  +     ++  +   G          P   T   G +V + C   G P
Sbjct: 380  CFARNAAGEVQTSTYLAVTSIAPNITRG----------PLDSTVIDGMSVVLACETSGAP 429

Query: 329  VPTITWMK-----VNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQ 383
             P ITW K      +G +            L I    + DAG Y C A NSRG +     
Sbjct: 430  RPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASAD 489

Query: 384  LQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYR--WLKNGVPLSPQSRVEMV-- 439
            L V+      +   D  +  G+     C  T  PR T R  W K+G  L  +S   +   
Sbjct: 490  LVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLD 549

Query: 440  -NGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKI--LASAPTFALNQL----KKTII 492
             NG L I      D G Y C   +  G    SA L++  L  AP   +  L    ++ I 
Sbjct: 550  RNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAIN 609

Query: 493  VTKDQ---------EVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASK 543
            +T  +           ++E     +P   +      +A     +  ++P  S +    + 
Sbjct: 610  LTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVK-GLVPARSYQFRLCAV 668

Query: 544  SDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVG---ESIVLNCKAIHDAS 600
            +D GK        F       SL  + PT     P +  +  G   +SI++  +   ++ 
Sbjct: 669  NDVGK------GQFSKDTERVSLPEEPPT----APPQNVIASGRTNQSIMIQWQPPPESH 718

Query: 601  LD-----VTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTT 655
             +         + L G P+ ++     F++I   A   +L++ ++++            +
Sbjct: 719  QNGILKGYIIRYCLAGLPVGYQ-----FKNI-TDADVNNLLLEDLIIWTNYEIEVAAYNS 772

Query: 656  ADS---VSDEAELLVRGPPG-PPGIVIVEEITESTATLSWS-PAADNHSPISS-YNLQAR 709
            A      S   E  ++G P  PPG V  E    +T   +W+ P+    + I+  Y L A 
Sbjct: 773  AGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAW 832

Query: 710  SPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTN 769
             P      T+ T        +       L  + EY   V+     G G  STP +++RT+
Sbjct: 833  EPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTP-QLVRTH 891

Query: 770  EAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSS 829
            E VP     ++S        L ++W+   E+  NG   GY ++        W+E   T++
Sbjct: 892  EDVPGPVG-HLSFSEILDTSLKVSWQEPGEK--NGILTGYRIS--------WEEYNRTNT 940

Query: 830  EASKFI------YRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVK 883
              + ++      YR   +  LT + ++V    +KG G  S   +      E    PT++ 
Sbjct: 941  RVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLG 1000

Query: 884  ATSVSVSEILVAWK---HIKESLGR-PQGFEVGYWKDMEQEDTAETVKTRGNESFVILTG 939
             +++    + + ++     K S+ R     +VG   + E+      +    +   + +  
Sbjct: 1001 ISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPD 1060

Query: 940  LEGNTLYHFTVRAYNGAGYGPPSS-EVSATTKKSPPSQAPSNLRWEQQG-SQVSLGWEPV 997
            L   T Y F +R  N  G  PPS       T ++PP  AP+N+       + + L W P+
Sbjct: 1061 LNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPL 1120

Query: 998  --IPLANESEVVGYKVFY-RQEGHSN--SQVIE--TQKLQAVVPLPDAGVYIIEVRAYSE 1050
              +      E VGYK+ Y R +GH    S V++   ++   +  L +   Y ++V+A++ 
Sbjct: 1121 PEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNA 1180

Query: 1051 GGDGTASSQIRVPSYSGGKITSAQSTLHSLSTSSSSV 1087
             G G  S  + V        +S  + + +L+T+SSS+
Sbjct: 1181 IGSGPWSQTV-VGRTRESVPSSGPTNVSALATTSSSM 1216



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 100/453 (22%), Positives = 179/453 (39%), Gaps = 45/453 (9%)

Query: 671  PGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVP-EIITGD 729
            PGPP  ++  E+  ++  L W P A  +  I +Y +  R    L   T  T   E++   
Sbjct: 1301 PGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHR----LNTTTANTATVEVLAPS 1356

Query: 730  MESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTN---VSGRSGR 786
                 A  L P   Y FR+ A    G G+ +    ++ T E   +  P +   V     R
Sbjct: 1357 ARQYTATGLKPESVYLFRITAQTRKGWGEAA--EALVVTTEKRDRPQPPSRPMVQQEDVR 1414

Query: 787  RHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTP 846
               ++++WEP S+       +       P+G        V S  AS FI   + + P T 
Sbjct: 1415 ARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASV-SHNASSFIV--DRLKPFTS 1471

Query: 847  FEVKVGVYNNKGDGPFSQ-IVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESL-- 903
            ++ +V   N+ GD  FS+    + + +  P  APT +  T  + + +L+ W+   E    
Sbjct: 1472 YKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKIN 1531

Query: 904  GRPQGFEVGY----------------------WKDMEQEDTAETVKTRGNESFVILTGLE 941
            G   GF + Y                      W ++    +   + +R + +   L  L 
Sbjct: 1532 GILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNL-SRPSLTQYELDNLN 1590

Query: 942  GNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWE-QQGSQVSLGWEPVIPL 1000
             +  Y   +  YN  G GP S        ++ P+ AP N+       +Q+ + WEP    
Sbjct: 1591 KHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLD 1650

Query: 1001 ANESEVVGYKVFY--RQEGHSNSQVIETQKLQAVVPLPDA---GVYIIEVRAYSEGGDGT 1055
            +   ++ GYK+++   Q G+   +V      +  V L +      Y++ V A++  GDG 
Sbjct: 1651 SQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGP 1710

Query: 1056 ASSQIRVPSYSGGKITSAQSTLHSLSTSSSSVT 1088
             S+  +  +        +      L+T+S +V+
Sbjct: 1711 RSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVS 1743



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 82/349 (23%), Positives = 144/349 (41%), Gaps = 22/349 (6%)

Query: 660  SDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTV 719
            S + + L   P   P  V +   +E++  L W P      P   YN    +P S+G++  
Sbjct: 1086 SRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPL-----PEMEYN---GNPESVGYKIK 1137

Query: 720  --------KTVPEIITGDMESAMAV-DLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNE 770
                    KT+  ++   +E    + DL  W EY  +V A N IG+G P + + + RT E
Sbjct: 1138 YSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSG-PWSQTVVGRTRE 1196

Query: 771  AVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSE 830
            +VP + PTNVS  +     +++ W  V E  +NG   GY V ++   +       +    
Sbjct: 1197 SVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGN 1256

Query: 831  ASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVS 890
            +S+       +     +EV+V  +   GDG  S   ++     +    P  +    V  +
Sbjct: 1257 SSRSAQLT-GLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTT 1315

Query: 891  EILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTV 950
             + + W+      G    +++ +  +    +TA       +      TGL+  ++Y F +
Sbjct: 1316 SVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRI 1375

Query: 951  RAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQ---GSQVSLGWEP 996
             A    G+G  +  +  TT+K    Q PS    +Q+      V L WEP
Sbjct: 1376 TAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEP 1424



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 41/132 (31%), Positives = 65/132 (49%), Gaps = 9/132 (6%)

Query: 647  RYGCRVQTTADSVSDEAELLV---RGPPGPPGIVIVEEITESTATLSWSPAADNHSPISS 703
            R+  R +T       EA +      G PGPPG+ I+   + + A + WS       PI+ 
Sbjct: 1798 RFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIA-IHWSSGDPGKGPITR 1856

Query: 704  YNLQARSPFSLGWQT-VKTVPEIITGDMESAMAVD-LNPWVEYEFRVVATNPIGTGDPST 761
            Y ++AR      W   +K +P+ ++       ++D L P V Y+FRV+A N  G G PS+
Sbjct: 1857 YVIEARPSDEGLWDILIKDIPKEVSS---YTFSMDILKPGVSYDFRVIAVNDYGFGTPSS 1913

Query: 762  PSRMIRTNEAVP 773
            PS+ +   +A P
Sbjct: 1914 PSQSVPAQKANP 1925



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 74/324 (22%), Positives = 121/324 (37%), Gaps = 40/324 (12%)

Query: 670  PPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQT-----VKTVPE 724
            P   P  V+V   T +   ++W P      P+ S N   +      W+       + V  
Sbjct: 1623 PTAAPRNVVVHGATATQLDVTWEPP-----PLDSQNGDIQGYKIYFWEAQRGNLTERVKT 1677

Query: 725  IITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRS 784
            +   +  S    +L  +  Y   V A N  G G  STP++  +T +A P +AP++V    
Sbjct: 1678 LFLAE-NSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQG-QTQQAAP-SAPSSVKFSE 1734

Query: 785  GRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASK----FIYRDES 840
                 + ++WE  + +F NG   GY + + P        K+VT             +D +
Sbjct: 1735 LTTTSVNVSWE--APQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLA 1792

Query: 841  VPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIK 900
                  F ++   +     GP  +  V  +  GE +  P  V       S I + W    
Sbjct: 1793 EGVTYRFRIRAKTFTY---GPEIEANVT-TGPGEGAPGPPGVPIIVRYSSAIAIHWSSGD 1848

Query: 901  ESLG---------RPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVR 951
               G         RP   + G W D+  +D  + V +      ++  G+     Y F V 
Sbjct: 1849 PGKGPITRYVIEARPS--DEGLW-DILIKDIPKEVSSYTFSMDILKPGVS----YDFRVI 1901

Query: 952  AYNGAGYGPPSS-EVSATTKKSPP 974
            A N  G+G PSS   S   +K+ P
Sbjct: 1902 AVNDYGFGTPSSPSQSVPAQKANP 1925


>gi|119220552 sidekick 1 [Homo sapiens]
          Length = 2213

 Score =  274 bits (700), Expect = 4e-73
 Identities = 268/1039 (25%), Positives = 431/1039 (41%), Gaps = 75/1039 (7%)

Query: 84   HSSDAFKQDESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEID 143
            H   A  QD   D  P F  EP   +     +  ++ L C   G+    ++W+R+ +E+ 
Sbjct: 92   HLLRALAQD---DVAPYFKTEPG--LPQIHLEGNRLVLTCLAEGSWPLEFKWMRDDSELT 146

Query: 144  L-ESDYRYSLIDGTFIISNPSEAK-DSGHYQCLATNTVGSILSREATLQFAYLGNFSGRT 201
               S+Y+Y +         PS  K D+G Y+C+  N +G++L R++ +Q AY+G+F   T
Sbjct: 147  TYSSEYKYII---------PSLQKLDAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMD-T 196

Query: 202  RSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQT 261
                +V +G+  +L   P    P    +W F E    +   S R        L I    T
Sbjct: 197  DQRKTVSQGRAAILNLLPITSYPRPQVTW-FREGHKIIP--SNRIAITLENQLVILATTT 253

Query: 262  SDVGSYICLVKNTVTNARVLSPPTPLTLRND-GVMGEYEPKIEVHFPFTVTAAKGTTVKM 320
            SD G+Y     N        SP   L++  D G      P I V        A  +   +
Sbjct: 254  SDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTL 313

Query: 321  ECFALGNPVP--TITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAE---NSR 375
            EC A   PV   ++TW K NG +   + L      L I N    D G Y C A    ++ 
Sbjct: 314  ECIASARPVEDLSVTW-KRNG-VRITSGLHSFGRRLTISNPTSADTGPYVCEAALPGSAF 371

Query: 376  GKNSFRGQLQVYTYPHWV-EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLS--- 431
                    L +   P++  E  +    +    +   C+A G P PT +W K+ + +S   
Sbjct: 372  EPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQ 431

Query: 432  -PQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKT 490
             P+ +V + +G L I  +   D+G++QC A N+ G I     L +   AP F    +  T
Sbjct: 432  NPRYKV-LASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTT 490

Query: 491  IIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENK----RIAILPDGSLRILNASKSDE 546
              VT     ++ C+  G+PKP I+WK+ +  +        R  +L  G L+I      D 
Sbjct: 491  --VTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDA 548

Query: 547  GKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFY 606
            G Y C   N  GS    A+L+V   T I   P+   +  G +  L+C A HD  + + + 
Sbjct: 549  GNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYV 608

Query: 607  WTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAEL- 665
            W      +          S         L+I        G Y C + +   + S  A L 
Sbjct: 609  WKKDNVALTPSST-----SRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLE 663

Query: 666  LVRGPPGPPGIVIVEEITESTAT-LSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPE 724
            ++  P  P  +++    + S A  LSW    D +SPI  Y ++     S     +  V  
Sbjct: 664  VIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGP 723

Query: 725  IITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRS 784
             +TG   S     L P   Y+FRV A N +G G  S  +  +   E  P   P N+    
Sbjct: 724  EMTGVTVSG----LTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASG 779

Query: 785  GRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRG-WKEKMVTSSEASKFIYRDESVPP 843
                 +++ W+P  E   NG   GYI+ +R  G  G ++++ +TS E +  +  D  +  
Sbjct: 780  RTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLII-- 837

Query: 844  LTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESL 903
             T +E++V  YN  G G FS+ V   + +G P+A P +V+  +V+ + I   W    +  
Sbjct: 838  WTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQF 897

Query: 904  --GRPQGFEVGYWKDMEQEDTAETVKTRGNESFVI----LTGLEGNTLYHFTVRAYNGAG 957
              G  QG+++  W     E  A TV T   +   +    +T L+  T Y  +V  +   G
Sbjct: 898  INGINQGYKLLAWPADAPE--AVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPG 955

Query: 958  YGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEG 1017
             GPPS+     T++  P         E   + + + W+   PL     + GY++ +   G
Sbjct: 956  DGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQE--PLEKNGIITGYQISWEVYG 1013

Query: 1018 HSNSQVIET-------QKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQIRVPSYSGGKI 1070
             ++S++  T        K+Q +  L     Y I+V A +  G G  +S   + S     +
Sbjct: 1014 RNDSRLTHTLNSTTHEYKIQGLSSLT---TYTIDVAAVTAVGTGLVTSS-TISSGVPPDL 1069

Query: 1071 TSAQSTLHSLSTSSSSVTL 1089
              A S L   + S  S TL
Sbjct: 1070 PGAPSNLVISNISPRSATL 1088



 Score =  126 bits (316), Expect = 1e-28
 Identities = 110/407 (27%), Positives = 186/407 (45%), Gaps = 38/407 (9%)

Query: 671  PGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLG----WQTVKTVPEII 726
            PG P  +++  I+  +ATL + P  D  + IS + ++ +   ++G    W T+    E  
Sbjct: 1070 PGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVG-AIGDEEEWVTL--YEEEN 1126

Query: 727  TGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGR 786
              D +     +L P+  Y FR+   N +G    S  SR+I+T +A P  APT+V+ R+  
Sbjct: 1127 EPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTAS 1186

Query: 787  RHELVIAWEPVSEEFQNG--EGFGYIVAFRPNGTRGWKEKMVTSSEA---SKFIYRDESV 841
               L + W P+ +   NG  E  GY + +       W+  + +S+ A   S  + R+ ++
Sbjct: 1187 ETSLRLRWVPLPDSQYNGNPESVGYRIKY-------WRSDLQSSAVAQVVSDRLEREFTI 1239

Query: 842  PPL---TPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKH 898
              L     +E+++  +N  G GP+S++V   + E  PSAAP +V A +VS ++IL+ W  
Sbjct: 1240 EELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTS 1299

Query: 899  IKESLGRPQGFEVGY-----WKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAY 953
            + E      G  +GY      KD++ E  +  V+    +S  +L GL    LY   V A+
Sbjct: 1300 VPEQ--DQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQS-ALLAGLRKFVLYELQVLAF 1356

Query: 954  NGAGYGPPSSEVSATTKKSPPSQAPSNLRW-EQQGSQVSLGWEPVIPLANESEVVGYKVF 1012
               G G PS+ +     K      P  L + E + + V + W+P  P      ++GY++ 
Sbjct: 1357 TRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQP--PEEPNGIILGYQIA 1414

Query: 1013 YRQEGHS-----NSQVIETQKLQAVVPLPDAGVYIIEVRAYSEGGDG 1054
            YR    S       +V  T +      L     YI  + A +  G G
Sbjct: 1415 YRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWG 1461



 Score =  124 bits (312), Expect = 4e-28
 Identities = 102/372 (27%), Positives = 166/372 (44%), Gaps = 32/372 (8%)

Query: 668  RGPPGPPGIVIVE--EITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEI 725
            R  P PP  ++V   E+T  +  L W P +D  SPI  + +Q R      WQT  +    
Sbjct: 1474 RERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSS--- 1530

Query: 726  ITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSG 785
            I+ +  + +   L P+  Y+ R+ ATN IG  D S+ +  + T + VP   P +VS    
Sbjct: 1531 ISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPH 1590

Query: 786  RRHELVIAWEPVSEEFQNGEGFGYIVAFRP------NGTRGWKEKM-------VTSSEAS 832
                ++I W+P  +E  NG   GY + +R       +GT     K        +T+  + 
Sbjct: 1591 TTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSF 1650

Query: 833  KFIYRDES--------VPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKA 884
            K +    +        +     +EV +  YN  G+ P S  V +   E  P+ AP +V+ 
Sbjct: 1651 KTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQV 1710

Query: 885  TSVSVSEILVAWKHI--KESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEG 942
            T ++ S++ V W     +   G  QG+++ YW+   Q +T +       E  V L  L  
Sbjct: 1711 TPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTS 1770

Query: 943  NTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRW-EQQGSQVSLGWEPVIPLA 1001
            +T Y  ++ A+N AG GP S      T ++ P  APS L + E   + +++ W    P A
Sbjct: 1771 HTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPG-APSFLAFSEITSTTLNVSWGE--PAA 1827

Query: 1002 NESEVVGYKVFY 1013
                + GY+V Y
Sbjct: 1828 ANGILQGYRVVY 1839



 Score =  102 bits (255), Expect = 2e-21
 Identities = 105/427 (24%), Positives = 178/427 (41%), Gaps = 54/427 (12%)

Query: 671  PGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDM 730
            PGPP  ++  E+  ++  + W P  + +  I  Y +  R   S    T  TV   +   +
Sbjct: 1378 PGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSP-HTFTTVE--VGATV 1434

Query: 731  ESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTN---VSGRSGRR 787
                A DL P   Y FR+ A    G G+P   +  + T E   + AP     V       
Sbjct: 1435 RQFTATDLAPESAYIFRLSAKTRQGWGEPLEAT--VITTEKRERPAPPRELLVPQAEVTA 1492

Query: 788  HELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPF 847
              L + W P S+       F   V   P G   W+    + S  +     D  + P T +
Sbjct: 1493 RSLRLQWVPGSDGASPIRYFTMQVRELPRGE--WQTYSSSISHEATACVVDR-LRPFTSY 1549

Query: 848  EVKVGVYNNKGDGPFS-QIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIK-ESL-G 904
            ++++   N+ GD  FS +   + + +  P   P  V AT  + S +L+ W+  + ESL G
Sbjct: 1550 KLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNG 1609

Query: 905  RPQGFEVGYWKDMEQE-----------------------DTAETVKTRGNESFVILTGLE 941
              QG+ + Y++++E E                        + +TV +    +   LT L+
Sbjct: 1610 LLQGYRI-YYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLK 1668

Query: 942  GNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQ-QGSQVSLGWEPVIPL 1000
                Y   + AYN  G  P S+ V     ++ P+ AP N++      SQ+ + W+P  P 
Sbjct: 1669 KYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPE 1728

Query: 1001 ANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGV----------YIIEVRAYSE 1050
            +    + GYK++Y +    N    ET+K++ V+ LP+  V          Y++ + A++ 
Sbjct: 1729 SQNGNIQGYKIYYWEADSQN----ETEKMK-VLFLPEPVVRLKNLTSHTKYLVSISAFNA 1783

Query: 1051 GGDGTAS 1057
             GDG  S
Sbjct: 1784 AGDGPKS 1790



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 104/442 (23%), Positives = 174/442 (39%), Gaps = 50/442 (11%)

Query: 670  PPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTV--------KT 721
            P   P  V V   +E++  L W P  D     S YN    +P S+G++            
Sbjct: 1173 PDVAPTSVTVRTASETSLRLRWVPLPD-----SQYN---GNPESVGYRIKYWRSDLQSSA 1224

Query: 722  VPEIITGDMESAMAVD-LNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNV 780
            V ++++  +E    ++ L  W+EYE ++ A N +G G  S   R  RT E+VP  AP NV
Sbjct: 1225 VAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRG-RTRESVPSAAPENV 1283

Query: 781  SGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNG---------TRGWKEKMVTSSEA 831
            S  +    ++++ W  V E+ QNG   GY + FR             RG   +    +  
Sbjct: 1284 SAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGL 1343

Query: 832  SKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSE 891
             KF+           +E++V  +   G+G  S  +++   + +    P  +    V ++ 
Sbjct: 1344 RKFVL----------YELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTS 1393

Query: 892  ILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVR 951
            + + W+  +E  G   G+++ Y        T  TV+          T L   + Y F + 
Sbjct: 1394 VRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLS 1453

Query: 952  AYNGAGYGPPSSEVSATTKKSPPSQAPSNL---RWEQQGSQVSLGWEPVIPLANESEVVG 1008
            A    G+G P      TT+K      P  L   + E     + L W P    A+      
Sbjct: 1454 AKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFT 1513

Query: 1009 YKV--FYRQEGHSNSQVIETQKLQAVVP-LPDAGVYIIEVRAYSEGGDGTASSQIR---- 1061
             +V    R E  + S  I  +    VV  L     Y + ++A ++ GD   SS+      
Sbjct: 1514 MQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTT 1573

Query: 1062 ---VPSYSGGKITSAQSTLHSL 1080
               VP    G +++   T  S+
Sbjct: 1574 LQDVPGEPPGSVSATPHTTSSV 1595



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 37/107 (34%), Positives = 51/107 (47%), Gaps = 6/107 (5%)

Query: 669  GPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQT-VKTVPEIIT 727
            G PG P  V+V + + S  TL W+      +P + Y ++AR      W   VK +P   T
Sbjct: 1901 GSPGSPRDVLVTK-SASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSAT 1959

Query: 728  GDMESAMAVD-LNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVP 773
                  +++D L   V YEFRVVA N  G G+PS PS  +      P
Sbjct: 1960 S---YTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAP 2003



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 87/337 (25%), Positives = 127/337 (37%), Gaps = 52/337 (15%)

Query: 670  PPGPPGIVIVEEITESTATLSWSPAA--DNHSPISSYNL---QARSPFSLGWQTVKTVPE 724
            P   P  V V  +T S   ++W P      +  I  Y +   +A S        V  +PE
Sbjct: 1701 PAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPE 1760

Query: 725  IITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRS 784
             +          +L    +Y   + A N  G G  S P +  RT++A P  AP+ ++   
Sbjct: 1761 PVV------RLKNLTSHTKYLVSISAFNAAGDGPKSDPQQG-RTHQAAPG-APSFLAFSE 1812

Query: 785  GRRHELVIAW-EPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPP 843
                 L ++W EP +    NG   GY V + P        K+VT      +  R   V  
Sbjct: 1813 ITSTTLNVSWGEPAAA---NGILQGYRVVYEPLAPVQGVSKVVTVEVRGNW-QRWLKVRD 1868

Query: 844  LTP-----FEVKVGVYNNKGDGPFSQIVVICS-AEGEPSAAPTDVKATSVSVSEILVAWK 897
            LT      F V+         GP  Q  +    AEG P + P DV  T  S SE+ + W 
Sbjct: 1869 LTKGVTYFFRVQARTITY---GPELQANITAGPAEGSPGS-PRDVLVTK-SASELTLQWT 1923

Query: 898  -----------HIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLY 946
                       ++ E+    +G    + KD+ +  T+ T+          L  L     Y
Sbjct: 1924 EGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLS---------LDKLRQGVTY 1974

Query: 947  HFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRW 983
             F V A N AGYG PS   + +T  S   +AP    W
Sbjct: 1975 EFRVVAVNEAGYGEPS---NPSTAVSAQVEAPFYEEW 2008


>gi|28373124 contactin 4 isoform b precursor [Homo sapiens]
          Length = 282

 Score =  249 bits (636), Expect = 1e-65
 Identities = 125/275 (45%), Positives = 180/275 (65%), Gaps = 7/275 (2%)

Query: 821  WKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPT 880
            W   ++ S++AS++++R+ESV P +PFEVKVGV+NNKG+GPFS   V+ SAE EP+  P 
Sbjct: 3    WMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPA 62

Query: 881  DVKATSVSVSEILVAWKH-IKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTG 939
             + A S+S ++I V W   ++++ GR QG+EV YW+  ++E+ A  ++T GN++   +T 
Sbjct: 63   SIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITN 122

Query: 940  LEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIP 999
            L+G+ LYH  V+AYN AG GP S+ V+ TT+K PPSQ P N+ W    S++ L W+ V  
Sbjct: 123  LKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKA 182

Query: 1000 LANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQ 1059
            L NESEV GYKV YR    S++ VIET K    + LP    YIIE++ +S+GGDG++S Q
Sbjct: 183  LDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQ 242

Query: 1060 IRVPSYS------GGKITSAQSTLHSLSTSSSSVT 1088
            IR+P  S       G  TS   TL ++ST   S+T
Sbjct: 243  IRIPKISNAYARGSGASTSNACTLSAISTIMISLT 277


>gi|237858682 neurofascin isoform 6 precursor [Homo sapiens]
          Length = 613

 Score =  244 bits (623), Expect = 3e-64
 Identities = 173/582 (29%), Positives = 260/582 (44%), Gaps = 38/582 (6%)

Query: 106 DDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI--DGTFIISNPS 163
           D I+ P D+    + + CE +GNP PS+ W RN    ++  D R S+    GT +I   S
Sbjct: 44  DHIVDPRDN----ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 99

Query: 164 EAKDS---GHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPP 220
             +     G YQC A N  G+ LS    LQ +    +       V V+EG  + L C+PP
Sbjct: 100 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPP 159

Query: 221 PHSPEIIYSWVFNEFPSFVAEDSRRFISQ-ETGNLYISKVQTSDVGS-YICLVKNTVTNA 278
           P  P  +  W+ +     + +D R  +SQ   G+LY S V   D+ + Y C  +   T+ 
Sbjct: 160 PGLPSPVIFWMSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHT 216

Query: 279 RVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAA----KGTTVKMECFALGNPVPTITW 334
             +    P TL+     G  E      +P    ++    +G  + +EC A G P P I W
Sbjct: 217 --IQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAW 274

Query: 335 MKVNGYIPS-KARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWV 393
            K  G +PS KA+       L I NV  +D+G Y C A N  G       ++V   P+W+
Sbjct: 275 YKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWL 334

Query: 394 EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLS---PQSRVEMVNGVLMIHNVNQ 450
           ++  +  L  G   R  C+A G P+PT +W+ NG PL    P    E+    ++  +   
Sbjct: 335 DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQI 394

Query: 451 SDAGMYQCLAENKYGAIYASAELKILASAPTFAL--NQLKKTIIVTKDQEVVIECKPQGS 508
           S   +YQC   N++G + A+A + +L   P      NQL + I+  + +   ++C   GS
Sbjct: 395 SSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR---LDCPFFGS 451

Query: 509 PKPTISW-KKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLS 567
           P PT+ W K G  +  +     +  +GSL I    K D+G Y C   N+ G AE    L 
Sbjct: 452 PIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLE 511

Query: 568 VKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIR 627
           VK+PTRI   P+      G ++ L C+  HD SL +T  W    +P+        +   R
Sbjct: 512 VKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL--------YIGNR 563

Query: 628 AQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRG 669
            +     L I  +     G Y C   T  D    +A L V G
Sbjct: 564 MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLG 605



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 97/374 (25%), Positives = 154/374 (41%), Gaps = 39/374 (10%)

Query: 121 LNCEVRGNPVPSYRWLRNGTEIDLESDY-RYSLIDGTFIISNPSEAKDSGHYQCLATNTV 179
           L C   G P P   W + G   DL SD  ++   +    I+N SE +DSG Y CLA+N +
Sbjct: 260 LECIASGVPTPDIAWYKKGG--DLPSDKAKFENFNKALRITNVSE-EDSGEYFCLASNKM 316

Query: 180 GSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFV 239
           GSI     +++      +    ++ + +  G+   L+C    + P+    W+ N  P   
Sbjct: 317 GSI-RHTISVRVKAAPYWLDEPKNLI-LAPGEDGRLVCRANGN-PKPTVQWMVNGEPLQS 373

Query: 240 AEDS-RRFISQETGNLYISKVQTSDVGSYICLVKNT----VTNARVLS---PPTPLTLRN 291
           A  +  R ++ +T  +     Q S    Y C   N     + NA V     PP  L+ RN
Sbjct: 374 APPNPNREVAGDT--IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRN 431

Query: 292 DGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGY---IPSKARLR 348
                             +        +++C   G+P+PT+ W K NG    +       
Sbjct: 432 Q----------------LIRVILYNRTRLDCPFFGSPIPTLRWFK-NGQGSNLDGGNYHV 474

Query: 349 KSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLR 408
                LEI  ++ +D GIY C A N  GK   + +L+V           D     G+ ++
Sbjct: 475 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 534

Query: 409 WECKATGKP--RPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGA 466
            EC+    P  + T  WLK+  PL   +R++  +  L I  V + D G Y C+A  +   
Sbjct: 535 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ 594

Query: 467 IYASAELKILASAP 480
             A A L +L + P
Sbjct: 595 DLAKAYLTVLGNCP 608



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 66/305 (21%), Positives = 124/305 (40%), Gaps = 40/305 (13%)

Query: 394 EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKN----GVPLSPQSRVEMVNGVLMIH--- 446
           +   D  +D    +  EC+A G P P++ W +N     +   P+  +   +G L+I    
Sbjct: 40  QSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 99

Query: 447 -NVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECK- 504
               +   G YQC A NK+G   ++     ++ +P +    L   ++V +   + ++C  
Sbjct: 100 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENL-DPVVVQEGAPLTLQCNP 158

Query: 505 PQGSPKPTISWKKGD-RAVRENKRIAILPDGSLRILNASKSD-EGKYVCRG--------- 553
           P G P P I W       + ++KR++   +G L   N    D +  Y C           
Sbjct: 159 PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQ 218

Query: 554 -ENVFGSAEIIASLSVKEPTRIELTPKRTE----LTVGESIVLNCKAIHDASLDVTFYWT 608
            +N F + +++ +  V E T   + P+ T     +  G  ++L C A    + D+ +Y  
Sbjct: 219 QKNPF-TLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWY-- 275

Query: 609 LKGQPIDFEEEGGHFESIRAQASSAD--LMIRNILLMHAGRYGCRVQTTADSVSDEAELL 666
                    ++GG   S +A+  + +  L I N+    +G Y C       S+     + 
Sbjct: 276 ---------KKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR 326

Query: 667 VRGPP 671
           V+  P
Sbjct: 327 VKAAP 331



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 38/178 (21%), Positives = 76/178 (42%), Gaps = 21/178 (11%)

Query: 476 LASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDR--AVRENKRIAILPD 533
           L   PT      K  I+  +D  ++IEC+ +G+P P+  W +  R   + ++ R+++   
Sbjct: 31  LTQPPTITKQSAKDHIVDPRDN-ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR 89

Query: 534 GSLRILN-----ASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKR----TELT 584
               +++       +  EG+Y C   N FG+A  +++    + ++  L PK       + 
Sbjct: 90  SGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA--LSNRIRLQVSKSPLWPKENLDPVVVQ 147

Query: 585 VGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILL 642
            G  + L C         V F+ +   +PI  ++         +Q  + DL   N++L
Sbjct: 148 EGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKR-------VSQGHNGDLYFSNVML 198


>gi|237858680 neurofascin isoform 5 precursor [Homo sapiens]
          Length = 619

 Score =  244 bits (623), Expect = 3e-64
 Identities = 173/582 (29%), Positives = 260/582 (44%), Gaps = 38/582 (6%)

Query: 106 DDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI--DGTFIISNPS 163
           D I+ P D+    + + CE +GNP PS+ W RN    ++  D R S+    GT +I   S
Sbjct: 50  DHIVDPRDN----ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 105

Query: 164 EAKDS---GHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPP 220
             +     G YQC A N  G+ LS    LQ +    +       V V+EG  + L C+PP
Sbjct: 106 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPP 165

Query: 221 PHSPEIIYSWVFNEFPSFVAEDSRRFISQ-ETGNLYISKVQTSDVGS-YICLVKNTVTNA 278
           P  P  +  W+ +     + +D R  +SQ   G+LY S V   D+ + Y C  +   T+ 
Sbjct: 166 PGLPSPVIFWMSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHT 222

Query: 279 RVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAA----KGTTVKMECFALGNPVPTITW 334
             +    P TL+     G  E      +P    ++    +G  + +EC A G P P I W
Sbjct: 223 --IQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAW 280

Query: 335 MKVNGYIPS-KARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWV 393
            K  G +PS KA+       L I NV  +D+G Y C A N  G       ++V   P+W+
Sbjct: 281 YKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWL 340

Query: 394 EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLS---PQSRVEMVNGVLMIHNVNQ 450
           ++  +  L  G   R  C+A G P+PT +W+ NG PL    P    E+    ++  +   
Sbjct: 341 DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQI 400

Query: 451 SDAGMYQCLAENKYGAIYASAELKILASAPTFAL--NQLKKTIIVTKDQEVVIECKPQGS 508
           S   +YQC   N++G + A+A + +L   P      NQL + I+  + +   ++C   GS
Sbjct: 401 SSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR---LDCPFFGS 457

Query: 509 PKPTISW-KKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLS 567
           P PT+ W K G  +  +     +  +GSL I    K D+G Y C   N+ G AE    L 
Sbjct: 458 PIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLE 517

Query: 568 VKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIR 627
           VK+PTRI   P+      G ++ L C+  HD SL +T  W    +P+        +   R
Sbjct: 518 VKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL--------YIGNR 569

Query: 628 AQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRG 669
            +     L I  +     G Y C   T  D    +A L V G
Sbjct: 570 MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLG 611



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 97/374 (25%), Positives = 154/374 (41%), Gaps = 39/374 (10%)

Query: 121 LNCEVRGNPVPSYRWLRNGTEIDLESDY-RYSLIDGTFIISNPSEAKDSGHYQCLATNTV 179
           L C   G P P   W + G   DL SD  ++   +    I+N SE +DSG Y CLA+N +
Sbjct: 266 LECIASGVPTPDIAWYKKGG--DLPSDKAKFENFNKALRITNVSE-EDSGEYFCLASNKM 322

Query: 180 GSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFV 239
           GSI     +++      +    ++ + +  G+   L+C    + P+    W+ N  P   
Sbjct: 323 GSI-RHTISVRVKAAPYWLDEPKNLI-LAPGEDGRLVCRANGN-PKPTVQWMVNGEPLQS 379

Query: 240 AEDS-RRFISQETGNLYISKVQTSDVGSYICLVKNT----VTNARVLS---PPTPLTLRN 291
           A  +  R ++ +T  +     Q S    Y C   N     + NA V     PP  L+ RN
Sbjct: 380 APPNPNREVAGDT--IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRN 437

Query: 292 DGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGY---IPSKARLR 348
                             +        +++C   G+P+PT+ W K NG    +       
Sbjct: 438 Q----------------LIRVILYNRTRLDCPFFGSPIPTLRWFK-NGQGSNLDGGNYHV 480

Query: 349 KSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLR 408
                LEI  ++ +D GIY C A N  GK   + +L+V           D     G+ ++
Sbjct: 481 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 540

Query: 409 WECKATGKP--RPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGA 466
            EC+    P  + T  WLK+  PL   +R++  +  L I  V + D G Y C+A  +   
Sbjct: 541 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ 600

Query: 467 IYASAELKILASAP 480
             A A L +L + P
Sbjct: 601 DLAKAYLTVLGNCP 614



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 66/305 (21%), Positives = 124/305 (40%), Gaps = 40/305 (13%)

Query: 394 EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKN----GVPLSPQSRVEMVNGVLMIH--- 446
           +   D  +D    +  EC+A G P P++ W +N     +   P+  +   +G L+I    
Sbjct: 46  QSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 105

Query: 447 -NVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECK- 504
               +   G YQC A NK+G   ++     ++ +P +    L   ++V +   + ++C  
Sbjct: 106 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENL-DPVVVQEGAPLTLQCNP 164

Query: 505 PQGSPKPTISWKKGD-RAVRENKRIAILPDGSLRILNASKSD-EGKYVCRG--------- 553
           P G P P I W       + ++KR++   +G L   N    D +  Y C           
Sbjct: 165 PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQ 224

Query: 554 -ENVFGSAEIIASLSVKEPTRIELTPKRTE----LTVGESIVLNCKAIHDASLDVTFYWT 608
            +N F + +++ +  V E T   + P+ T     +  G  ++L C A    + D+ +Y  
Sbjct: 225 QKNPF-TLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWY-- 281

Query: 609 LKGQPIDFEEEGGHFESIRAQASSAD--LMIRNILLMHAGRYGCRVQTTADSVSDEAELL 666
                    ++GG   S +A+  + +  L I N+    +G Y C       S+     + 
Sbjct: 282 ---------KKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR 332

Query: 667 VRGPP 671
           V+  P
Sbjct: 333 VKAAP 337



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 38/178 (21%), Positives = 76/178 (42%), Gaps = 21/178 (11%)

Query: 476 LASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDR--AVRENKRIAILPD 533
           L   PT      K  I+  +D  ++IEC+ +G+P P+  W +  R   + ++ R+++   
Sbjct: 37  LTQPPTITKQSAKDHIVDPRDN-ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR 95

Query: 534 GSLRILN-----ASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKR----TELT 584
               +++       +  EG+Y C   N FG+A  +++    + ++  L PK       + 
Sbjct: 96  SGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA--LSNRIRLQVSKSPLWPKENLDPVVVQ 153

Query: 585 VGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILL 642
            G  + L C         V F+ +   +PI  ++         +Q  + DL   N++L
Sbjct: 154 EGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKR-------VSQGHNGDLYFSNVML 204


>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
            precursor [Homo sapiens]
          Length = 2012

 Score =  239 bits (609), Expect = 1e-62
 Identities = 243/933 (26%), Positives = 393/933 (42%), Gaps = 75/933 (8%)

Query: 118  KVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATN 177
            +V+L+C V G       W RNG  ++   + R + I+   +I +     D G YQC    
Sbjct: 330  QVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRK 389

Query: 178  TVGSILSREATLQFAYLGNFSGRTRSAVS---VREGQGVVLMCSPPPHSPEIIYSWVFNE 234
                 LS +  +Q   L + + +  SA S   V   + V LMC+    +P    +W  ++
Sbjct: 390  DK---LSAQDYVQVV-LEDGTPKIISAFSEKVVSPAEPVSLMCNVKG-TPLPTITWTLDD 444

Query: 235  FPSFVAEDSR--RFISQETGN----LYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLT 288
             P       R  + I+ E GN    L IS  Q  D G Y C   N+              
Sbjct: 445  DPILKGGSHRISQMITSE-GNVVSYLNISSSQVRDGGVYRCTANNSA------------- 490

Query: 289  LRNDGVMGEYEPKIEVHFPFTV------TAAKGTTVKMECFALGNPVPTITWMKVNGYIP 342
                GV+  Y+ +I V  P ++      TA  G    + C  +G P  +I W K +  +P
Sbjct: 491  ----GVV-LYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLP 545

Query: 343  SKAR--LRKSQAVLEIPNVQLD-DAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDT 399
               R    ++   L++ +VQ + D G Y C        ++ +        P +++     
Sbjct: 546  FNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFP 605

Query: 400  QLDSGSPLRWECKATGKPRP-TYRWLKNGVPLSPQSRVEMVN----GVLMIHNVNQSDAG 454
            +   G  +   C       P T  W K+G P+     V + N      L I N++    G
Sbjct: 606  RFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNG 665

Query: 455  MYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTIS 514
             Y C+A N+  A+   ++L I+   P F +    +  I  K   V++ C  +G P PTI 
Sbjct: 666  NYTCIARNEAAAVEHQSQL-IVRVPPKFVVQPRDQDGIYGK--AVILNCSAEGYPVPTIV 722

Query: 515  WKKGDRA-------VRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIAS-- 565
            WK    A       +  N RI +L +GSL I +  + D G Y+C+  N  G A++  S  
Sbjct: 723  WKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVG-ADVSKSMY 781

Query: 566  LSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFES 625
            L+VK P  I   P  T  T G+   ++C A  +  + V   W  + + I+  E   +  S
Sbjct: 782  LTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVR--WEKEDRIIN-PEMARYLVS 838

Query: 626  IRAQASS--ADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEIT 683
             +       + L I   +   +G + C    +        +L V+ PP PP I I +++ 
Sbjct: 839  TKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEI-KDVK 897

Query: 684  ESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVE 743
              T TL W+   D +SPI+ Y+++ ++  S  W + +   ++ +  + SA  +D++P   
Sbjct: 898  ARTITLRWTMGFDGNSPITGYDIECKNK-SDSWDSAQRTKDV-SPQLNSATIIDIHPSST 955

Query: 744  YEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQN 803
            Y  R+ A N IG  +PS     I  +EA P   P  V         + + W+   +  QN
Sbjct: 956  YSIRMYAKNRIGKSEPSN-ELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQN 1014

Query: 804  GEGFGYIVAFRPNGTRGWKEKMVTSSEAS--KFIYRDESVPPLTPFEVKVGVYNNKGDGP 861
            G   GY + +R   T G  +  + S + S    +Y  +++   T + + V   N  G GP
Sbjct: 1015 GIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGP 1074

Query: 862  FSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHI-KESL-GRPQGFEVGYWKDMEQ 919
             SQ ++  + E  PS  P +V+A + S   I ++W  + KE+L G  QGF V YW ++  
Sbjct: 1075 SSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMD 1134

Query: 920  EDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPS 979
             +  E       +  + L GLE  T Y   V A+  AG G  S ++   TK+  P     
Sbjct: 1135 GELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAG 1194

Query: 980  NLRWEQQGSQVSLGWEPVIPLANESEVVGYKVF 1012
                    S V + W P  PL     +  Y VF
Sbjct: 1195 VKAAAASASMVFVSWLP--PLKLNGIIRKYTVF 1225



 Score =  177 bits (450), Expect = 4e-44
 Identities = 199/821 (24%), Positives = 333/821 (40%), Gaps = 68/821 (8%)

Query: 114  SDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI---DG---TFIISNPSEAKD 167
            S  + V+L C V+G P+P+  W  +   I     +R S +   +G   +++  + S+ +D
Sbjct: 419  SPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRD 478

Query: 168  SGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEII 227
             G Y+C A N+ G +L +    +    G  S R    ++   G+   + C    + P   
Sbjct: 479  GGVYRCTANNSAGVVLYQ---ARINVRGPASIRPMKNITAIAGRDTYIHCRVIGY-PYYS 534

Query: 228  YSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTS-DVGSYICLVKNTVTNARVLSPPTP 286
              W  N   + +  + R+   +  G L +S VQ   D G Y C          VL  P  
Sbjct: 535  IKWYKNS--NLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTC---------NVLVQPQL 583

Query: 287  LTLRNDGVMGEYEPKIE-VHFP-FTVTAAKGTTVKMECFALGNPVP-TITWMKVNGYIPS 343
             T ++  V  +  P I+   FP F++    G  V + C  +   +P TITW K    IP 
Sbjct: 584  STSQSVHVTVKVPPFIQPFEFPRFSI----GQRVFIPCVVVSGDLPITITWQKDGRPIPG 639

Query: 344  KARLRKSQ----AVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDT 399
               +        + L I N+ L   G Y C A N       + QL V   P +V +  D 
Sbjct: 640  SLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQ 699

Query: 400  QLDSGSPLRWECKATGKPRPTYRW-------LKNGVPLSPQSRVEMV-NGVLMIHNVNQS 451
                G  +   C A G P PT  W       +    P++   R++++ NG L+I +V + 
Sbjct: 700  DGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEE 759

Query: 452  DAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKP 511
            D+G Y C   N  GA   S  + +    P   +     T + T+ Q+  + C   G    
Sbjct: 760  DSGYYLCKVSNDVGA-DVSKSMYLTVKIPAM-ITSYPNTTLATQGQKKEMSCTAHGEKPI 817

Query: 512  TISWKKGDRAVR--------ENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEII 563
             + W+K DR +           K +      +L+IL   + D G + C   N +G    I
Sbjct: 818  IVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGI 877

Query: 564  ASLSVKEPTRIELTPKRTEL--TVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGG 621
              L+V+EP      P   E+      +I L      D +  +T Y        D  +   
Sbjct: 878  IQLTVQEPP----DPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQ 933

Query: 622  HFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLV--RGPPGPPGIVIV 679
              + +  Q +SA ++  +    ++ R   + +      S+E  +      P GPP  V +
Sbjct: 934  RTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHL 993

Query: 680  EEITESTATLSWSPAADN--HSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVD 737
            E I+  +  ++W     +  +  I  Y +  R   + G      +    +GD E     +
Sbjct: 994  EPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDN 1053

Query: 738  LNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPV 797
            LN + +Y   V A N  GTG PS+   +  T E VP   P NV   +     + I+W  +
Sbjct: 1054 LNKFTQYGLVVQACNRAGTG-PSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTL 1112

Query: 798  SEEFQNGEGFGYIVAFRPNGTRG--WKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYN 855
            S+E  NG   G+ V +  N   G   + K +T+++ S  +   + +   T + ++V  + 
Sbjct: 1113 SKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLEL---DGLEKYTNYSIQVLAFT 1169

Query: 856  NKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAW 896
              GDG  S+ +   + E  P   P  VKA + S S + V+W
Sbjct: 1170 RAGDGVRSEQIFTRTKEDVP-GPPAGVKAAAASASMVFVSW 1209



 Score =  166 bits (419), Expect = 1e-40
 Identities = 231/1011 (22%), Positives = 386/1011 (38%), Gaps = 137/1011 (13%)

Query: 117  KKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLAT 176
            ++V L C+  G+P P YRWL++   ++L   ++ ++   T ++       DSG Y C  +
Sbjct: 240  QRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTV---TGLLIENIRPSDSGSYVCEVS 296

Query: 177  NTVGS--ILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNE 234
            N  G+  ++ R    Q         + +S+V    G  V L CS      + + SW +  
Sbjct: 297  NRYGTAKVIGRLYVKQPLKATISPRKVKSSV----GSQVSLSCSVTGTEDQEL-SW-YRN 350

Query: 235  FPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNAR-----VLSPPTP--L 287
                    + R       NL +  +  SD G+Y C V+    +A+     VL   TP  +
Sbjct: 351  GEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKII 410

Query: 288  TLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARL 347
            +  ++ V+   EP                 V + C   G P+PTITW   +  I      
Sbjct: 411  SAFSEKVVSPAEP-----------------VSLMCNVKGTPLPTITWTLDDDPILKGGSH 453

Query: 348  RKSQAV---------LEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLND 398
            R SQ +         L I + Q+ D G+Y C A NS G   ++ ++ V   P  +  + +
Sbjct: 454  RISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINV-RGPASIRPMKN 512

Query: 399  TQLDSGSPLRWECKATGKPRPTYRWLKNG--VPLSPQSRVEMVNGVLMIHNVNQS-DAGM 455
                +G      C+  G P  + +W KN   +P + +      NG L + +V +  D G 
Sbjct: 513  ITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGE 572

Query: 456  YQC--LAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKP-T 512
            Y C  L + +   +  S  + +    P F   Q  +    +  Q V I C       P T
Sbjct: 573  YTCNVLVQPQ---LSTSQSVHVTVKVPPFI--QPFEFPRFSIGQRVFIPCVVVSGDLPIT 627

Query: 513  ISWKKGDRAVRENKRIAILP---DGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVK 569
            I+W+K  R +  +  + I       SLRI N S    G Y C   N   + E  + L V+
Sbjct: 628  ITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVR 687

Query: 570  EPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTL-KG------QPIDFEEEGGH 622
             P +  + P+  +   G++++LNC A  +     T  W   KG      QPI      G 
Sbjct: 688  VPPKFVVQPRDQDGIYGKAVILNCSA--EGYPVPTIVWKFSKGAGVPQFQPIAL---NGR 742

Query: 623  FESIRAQASSADLMIRNILLMHAGRYGCRVQTTADS-VSDEAELLVRGPPGPPGIVIVEE 681
             + +    S+  L+I++++   +G Y C+V     + VS    L V+ P       ++  
Sbjct: 743  IQVL----SNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIP------AMITS 792

Query: 682  ITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPW 741
               +T       A        S       P  + W+    +               +NP 
Sbjct: 793  YPNTTL------ATQGQKKEMSCTAHGEKPIIVRWEKEDRI---------------INP- 830

Query: 742  VEYEFRVVATNPIGTGDPSTPSRM--IRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSE 799
             E    +V+T  +G    ST   +  +R +         N  G      +L +   P   
Sbjct: 831  -EMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPP 889

Query: 800  EFQNGEGFGYIVAFR-------PNGTRGWKEKMVTSSEASKFIYRDESVPP--------- 843
            E +  +     +  R        +   G+  +    S++     R + V P         
Sbjct: 890  EIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIID 949

Query: 844  ---LTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIK 900
                + + +++   N  G    S  + I + E  P   P +V    +S   I V WK  K
Sbjct: 950  IHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPK 1009

Query: 901  ESL--GRPQGFEVGYWK---DMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNG 955
            + L  G  +G+++GY +       +    +V T G+     L  L   T Y   V+A N 
Sbjct: 1010 KHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNR 1069

Query: 956  AGYGPPSSEVSATTKKSPPSQAPSNLR-WEQQGSQVSLGWEPVIPLANESEVVGYKVFY- 1013
            AG GP S E+  TT +  PS  P N++        +S+ W  +   A    + G++V Y 
Sbjct: 1070 AGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYW 1129

Query: 1014 --RQEGHSN--SQVIETQKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQI 1060
                +G       +  TQ    +  L     Y I+V A++  GDG  S QI
Sbjct: 1130 ANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQI 1180



 Score =  121 bits (304), Expect = 3e-27
 Identities = 140/570 (24%), Positives = 224/570 (39%), Gaps = 39/570 (6%)

Query: 123 CEVRGNPVPSYRW-LRNGTEIDLESDYRYSLIDGTFII-----SNPSEAKDSGHYQCLAT 176
           C   G P  + RW L  G EI      R+   +GT  I     S+ S       Y C A 
Sbjct: 46  CPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAE 105

Query: 177 NTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFP 236
           N  G I S++  ++      ++ R     ++R G   V  C  P  S E   + V  E  
Sbjct: 106 NPSGKIRSQDVHIKAVLREPYTVRVEDQKTMR-GNVAVFKCIIPS-SVEAYITVVSWEKD 163

Query: 237 SFVAEDSRRFISQETGNLYISKVQTSD-VGSYICLVKNTVTNARVLSPPTPLTLRNDGVM 295
           +       RF+   TG LYI  VQ  D + +Y C+ ++  T     S    L + +    
Sbjct: 164 TVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPA-- 221

Query: 296 GEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLE 355
               P I   F      A G  V++ C ALG+P P   W+K N  +    R +K+   L 
Sbjct: 222 -NSAPSILDGFDHRKAMA-GQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLL 279

Query: 356 IPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATG 415
           I N++  D+G Y C   N  G     G+L V             +   GS +   C  TG
Sbjct: 280 IENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTG 339

Query: 416 KPRPTYRWLKNGVPLSPQSRVEMVNGV----LMIHNVNQSDAGMYQCLAENKYGAIYASA 471
                  W +NG  L+P   V  + G+    L++ ++ +SD G YQC    +   + A  
Sbjct: 340 TEDQELSWYRNGEILNPGKNVR-ITGINHENLIMDHMVKSDGGAYQCFV--RKDKLSAQD 396

Query: 472 ELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRE--NKRIA 529
            ++++    T  +       +V+  + V + C  +G+P PTI+W   D  + +  + RI+
Sbjct: 397 YVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRIS 456

Query: 530 --ILPDGS----LRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTEL 583
             I  +G+    L I ++   D G Y C   N  G     A ++V+ P  I    K    
Sbjct: 457 QMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIR-PMKNITA 515

Query: 584 TVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILL- 642
             G    ++C+ I      + +Y      P +  +         A  ++  L + ++   
Sbjct: 516 IAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQV--------AFENNGTLKLSDVQKE 567

Query: 643 MHAGRYGCRVQTTAD-SVSDEAELLVRGPP 671
           +  G Y C V      S S    + V+ PP
Sbjct: 568 VDEGEYTCNVLVQPQLSTSQSVHVTVKVPP 597



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 231/1065 (21%), Positives = 387/1065 (36%), Gaps = 180/1065 (16%)

Query: 99   PVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVP-SYRWLRNGTEIDLESDYRYSLIDGT- 156
            P F+Q  +   FP  S  ++V + C V    +P +  W ++G  I          ID T 
Sbjct: 596  PPFIQPFE---FPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTS 652

Query: 157  -FIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVL 215
               ISN S    +G+Y C+A N   ++   ++ L       F  + R    +  G+ V+L
Sbjct: 653  SLRISNLS-LMHNGNYTCIARNEAAAV-EHQSQLIVRVPPKFVVQPRDQDGIY-GKAVIL 709

Query: 216  MCSPPPHS-PEIIYSWVFNE---FPSF--VAEDSRRFISQETGNLYISKVQTSDVGSYIC 269
             CS   +  P I+  W F++    P F  +A + R  +    G+L I  V   D G Y+C
Sbjct: 710  NCSAEGYPVPTIV--WKFSKGAGVPQFQPIALNGRIQVLSN-GSLLIKHVVEEDSGYYLC 766

Query: 270  LVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPV 329
             V N V     +S    LT++   ++  Y        P T  A +G   +M C A G   
Sbjct: 767  KVSNDV--GADVSKSMYLTVKIPAMITSY--------PNTTLATQGQKKEMSCTAHGEKP 816

Query: 330  PTITWMKVNGYI-PSKARLRKSQ--------AVLEIPNVQLDDAGIYECRAENSRGKNSF 380
              + W K +  I P  AR   S         + L+I     +D+G + C A NS G++  
Sbjct: 817  IIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRG 876

Query: 381  RGQLQVYTYPHWVE-KLNDTQ-----------LDSGSPLRW---ECKATGKPRPTYRWLK 425
              QL V   P   E ++ D +            D  SP+     ECK       + +  K
Sbjct: 877  IIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTK 936

Query: 426  NGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILA--SAPTFA 483
            +   +SPQ     +N   +I +++ S     +  A+N+ G    S EL I A  +AP   
Sbjct: 937  D---VSPQ-----LNSATII-DIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPD-- 985

Query: 484  LNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASK 543
                         QEV +E  P  S    ++WK    A +++ +  I+    +     S 
Sbjct: 986  ----------GPPQEVHLE--PISSQSIRVTWK----APKKHLQNGIIRGYQIGYREYST 1029

Query: 544  SDEGKYVCRGENVFGSAEIIA----------SLSVKEPTRIELTPKRTEL--TVGESIVL 591
                ++     +  G +E+             L V+   R    P   E+  T  E +  
Sbjct: 1030 GGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPS 1089

Query: 592  ----NCKAIHDASLDVTFYW-TLKGQPID--------------FEEEGGHFESIRAQASS 632
                N +AI  +   ++  W TL  + ++               + E G  ++I     S
Sbjct: 1090 YPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPS 1149

Query: 633  ADL---------MIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEIT 683
             +L          I+ +    AG  G R +       ++        PGPP  V     +
Sbjct: 1150 LELDGLEKYTNYSIQVLAFTRAGD-GVRSEQIFTRTKEDV-------PGPPAGVKAAAAS 1201

Query: 684  ESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVE 743
             S   +SW P    +  I  Y +    P+       +  P     D  S    +L+   +
Sbjct: 1202 ASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASP-----DSFSYRIPNLSRNRQ 1256

Query: 744  YEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGR-----RHELVIAWEPVS 798
            Y   VVA    G G+ S     I T E + K AP  +   SG        ++V+  + V 
Sbjct: 1257 YSVWVVAVTSAGRGNSSE----IITVEPLAK-APARILTFSGTVTTPWMKDIVLPCKAVG 1311

Query: 799  EEFQNGEGFGYIVAFRPNGTRGW-KEKMVTSS----EASKFIYRDESVPPLTPFEVKVGV 853
            +               P+    W K+   T S    +  + I+ + S    T      G 
Sbjct: 1312 D---------------PSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGY 1356

Query: 854  YNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGY 913
            Y+   +  +    +I + + +       +  +  + S I ++W          +G+ + Y
Sbjct: 1357 YSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQY 1416

Query: 914  WKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSA-TTKKS 972
             +D  ++  +  +    +E    L  L+  T Y FT+ A NG G G  S  + A T  K 
Sbjct: 1417 SEDNSEQWGSFPISP--SERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKE 1474

Query: 973  PPSQAPSNLRWEQQGSQVSL---GWE----PVIPLANESEVVGYKVFYRQEGHSNSQVIE 1025
            P       L      ++V L   GW     P+     E    G  V+      + +Q   
Sbjct: 1475 PQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVW------TTAQRTS 1528

Query: 1026 TQKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQIRVPSYSGGKI 1070
              K   +  L +A  Y +++R  +  G     +     +Y G  I
Sbjct: 1529 LSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTI 1573


>gi|19743806 roundabout 1 isoform b [Homo sapiens]
          Length = 1612

 Score =  219 bits (558), Expect = 1e-56
 Identities = 225/855 (26%), Positives = 339/855 (39%), Gaps = 82/855 (9%)

Query: 96  DYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESD----YRYS 151
           D+ P  V+ P D+I    S  +   LNC+  G P P+  W + G  ++ + D    +R  
Sbjct: 26  DFPPRIVEHPSDLIV---SKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 82

Query: 152 LIDGTF----IISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSV 207
           L  G+     I+       D G Y C+A N +G  +S  A+L+ A L +   +  S V V
Sbjct: 83  LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 142

Query: 208 REGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSY 267
             G+  V+ C PP   PE   SW  +  P    +D    I+   G L I+  + SD G Y
Sbjct: 143 AVGEPAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIRGGKLMITYTRKSDAGKY 199

Query: 268 ICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGN 327
           +C+  N V      S    LT+         E    V  P  +      + + +C A G+
Sbjct: 200 VCVGTNMVGERE--SEVAELTV--------LERPSFVKRPSNLAVTVDDSAEFKCEARGD 249

Query: 328 PVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVY 387
           PVPT+ W K +G +P      +    L+I  V   D G Y C AEN  GK      L V 
Sbjct: 250 PVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309

Query: 388 TYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNG--------VPLSPQSRVEM- 438
             PH+V K  D  +  G  + ++C+ATG P+P   W + G         P    SR  + 
Sbjct: 310 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 369

Query: 439 VNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELK---ILASAPTFALNQLKKTIIVTK 495
             G L I NV +SD G Y C   N  G+I   A L+   ++A  P   + Q      V  
Sbjct: 370 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 429

Query: 496 DQEVVIECKPQGSPKPTISWKK-GDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGE 554
           D   V+ C   GSP PTI W+K G     ++ RI  L +G L+I  A   D G+Y C   
Sbjct: 430 DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAS 489

Query: 555 NVFGSAEIIASLSVKE------------PTRIELTPKRTELT--VGESIVLNCKAIHDAS 600
              G A   A + V+E            P  I   P + E+T     ++ L+ +   ++ 
Sbjct: 490 TPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG 549

Query: 601 LDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRN----ILLMHAGRYG------- 649
              T Y                 E+++ + S+   +  N     L+  A  YG       
Sbjct: 550 ATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQI 609

Query: 650 ---CRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSP-ISSYN 705
               + Q    +        V+   G   + +      S++++      D  S  I  Y 
Sbjct: 610 SDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYK 669

Query: 706 LQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRV-VATNPIGTGDPSTPSR 764
           +  R   +   ++   V E+ T    S +  DL   V YE +     N     D  +  +
Sbjct: 670 ILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGAD--SEIK 727

Query: 765 MIRTNEAVPKTAP--TNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWK 822
             +T E  P   P    VS   G    ++++W+P  E+ QNG    Y V    N TR   
Sbjct: 728 FAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHI 787

Query: 823 EKMVTSSEASKFIYRDESVPPLTP---FEVKVGVYNNKGDGPFSQIVVI-CSAEGEPSAA 878
            K V  S  S  I      P L P   + V+V      G G  S+   I   A G P  +
Sbjct: 788 NKTVDGSTFSVVI------PFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNP-VS 840

Query: 879 PTDVKATSVSVSEIL 893
           P D  + +  +S+++
Sbjct: 841 PEDQVSLAQQISDVV 855



 Score =  175 bits (443), Expect = 2e-43
 Identities = 205/765 (26%), Positives = 303/765 (39%), Gaps = 106/765 (13%)

Query: 263 DVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMEC 322
           D G Y+C+ +N +  A   +    + +  D              P  V  A G    MEC
Sbjct: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN---------PSDVMVAVGEPAVMEC 152

Query: 323 FA-LGNPVPTITWMKVNGYIPSK-ARLRKSQAVLEIPNVQLDDAGIYECRAENSRG-KNS 379
               G+P PTI+W K    +  K  R+      L I   +  DAG Y C   N  G + S
Sbjct: 153 QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212

Query: 380 FRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMV 439
              +L V   P +V++ ++  +       ++C+A G P PT RW K+   L P+SR E+ 
Sbjct: 213 EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL-PKSRYEIR 271

Query: 440 NG-VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQE 498
           +   L I  V   D G Y C+AEN  G   ASA L +    P F +    +  +V   + 
Sbjct: 272 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV-QEPPHFVVKPRDQ--VVALGRT 328

Query: 499 VVIECKPQGSPKPTISWKKGD--------RAVRENKRIAILPDGSLRILNASKSDEGKYV 550
           V  +C+  G+P+P I W++          +  + + R ++   G L I N  +SD G Y+
Sbjct: 329 VTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYI 388

Query: 551 CRGENVFGSAEIIASLSVKE------PTRIELTPKRTELTVGESIVLNCKAIHDASLDVT 604
           C+  NV GS    A L V +      P  I   P    + V  + VL+C A    S   T
Sbjct: 389 CQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT--GSPVPT 446

Query: 605 FYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAE 664
             W   G  +  ++      S   Q  +  L IR   L   GRY C   T +   +  A 
Sbjct: 447 ILWRKDGVLVSTQD------SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAY 500

Query: 665 LLVRG------PPGP---------PGIVIVEEITESTATLSWSPAADNHSPISSYNLQAR 709
           + V+       PP P         P    V +++ +T TLSW P  ++ +  +SY ++A 
Sbjct: 501 IEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAF 560

Query: 710 SPFS-LGWQT----VKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSR 764
           S  S   WQT    VKT    I G         L P   Y F V A N  G  DPS  S 
Sbjct: 561 SHASGSSWQTVAENVKTETSAIKG---------LKPNAIYLFLVRAANAYGISDPSQISD 611

Query: 765 MIRTNEAVPKTA--------------------PTNVSGRSGRRHELVIAWEPVSEEFQNG 804
            ++T + +P +                     PT +S  S   H  V   +  S+  Q  
Sbjct: 612 PVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV---DQQSQYIQ-- 666

Query: 805 EGFGYIVAFRPNGTR----GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDG 860
              GY + +RP+G       W    V +   +  +  D  +     +E+K   + N+  G
Sbjct: 667 ---GYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPD--LRKGVNYEIKARPFFNEFQG 721

Query: 861 PFSQIVVICSAEGEPSAAP--TDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDME 918
             S+I    + E  PSA P    V     + + ILV+W+   E        E   W  + 
Sbjct: 722 ADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW-CLG 780

Query: 919 QEDTAETVKTRGNESF-VILTGLEGNTLYHFTVRAYNGAGYGPPS 962
            E      KT    +F V++  L     Y   V A  GAG G  S
Sbjct: 781 NETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKS 825



 Score =  129 bits (323), Expect = 2e-29
 Identities = 190/794 (23%), Positives = 312/794 (39%), Gaps = 113/794 (14%)

Query: 36  RIKKSSSSSLFGSKTRPRYSSPSLGTLSASSPSWLGAAQNYYSPINLYHSSDAFKQDESV 95
           R+   S S  F      R S P  G     + ++LG A ++ + + +    D F+Q+   
Sbjct: 80  RMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN--- 136

Query: 96  DYGPVFVQEPDDIIFPTDSDEKKVALNCE-VRGNPVPSYRWLRNGTEIDLESDYRYSLID 154
                    P D++       +   + C+  RG+P P+  W ++G+ +D + D R ++  
Sbjct: 137 ---------PSDVMVAVG---EPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITIRG 183

Query: 155 GTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGR-TRSAVSVREGQGV 213
           G  +I+  +   D+G Y C+ TN VG   S  A L      +F  R +  AV+V +    
Sbjct: 184 GKLMITY-TRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEF 242

Query: 214 VLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKN 273
                  P  P + +     E P        R+  ++   L I KV   D+GSY C+ +N
Sbjct: 243 KCEARGDP-VPTVRWRKDDGELP------KSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN 295

Query: 274 TVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTIT 333
            V  A        LT++        EP   V  P     A G TV  +C A GNP P I 
Sbjct: 296 MVGKAEA---SATLTVQ--------EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF 344

Query: 334 WMK------VNGYIP--SKARLRKSQ-AVLEIPNVQLDDAGIYECRAENSRGKNSFRGQL 384
           W +      +  Y P  S +R   SQ   L I NVQ  D G Y C+  N  G    +  L
Sbjct: 345 WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYL 404

Query: 385 QVYTY-----PHWVEK--LNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQ-SRV 436
           +V        P  + +  +N T    G+     C ATG P PT  W K+GV +S Q SR+
Sbjct: 405 EVTDVIADRPPPVIRQGPVNQTVAVDGT-FVLSCVATGSPVPTILWRKDGVLVSTQDSRI 463

Query: 437 -EMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKI-----------------LAS 478
            ++ NGVL I      D G Y C+A    G    SA +++                 + S
Sbjct: 464 KQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPS 523

Query: 479 APT--FALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGD--RAVRENKRIAILPDG 534
           AP+     +  + T+ ++    +     P        S   G   + V EN +       
Sbjct: 524 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTE----- 578

Query: 535 SLRILNASKSDEGKYVCRGENVFG---SAEIIASLSVKE--PTRIELTPKRTELTVGESI 589
           +  I     +    ++ R  N +G    ++I   +  ++  PT   +  K+ +  +G ++
Sbjct: 579 TSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAV 638

Query: 590 --VLNCKAIHDASLDVTFYWT-------LKGQPIDFEEEGGHFESIRAQASSADLMIRNI 640
             + N   +  +S++V  +WT       ++G  I +   G +               +N 
Sbjct: 639 LHLHNPTVLSSSSIEV--HWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNS 696

Query: 641 LLMHAGRYGCRVQTT----------ADSVSDEAELLVRGPPGPP-GIVIVEEITESTATL 689
           +++   R G   +            ADS    A+ L   P  PP G+ + +     TA L
Sbjct: 697 VVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAIL 756

Query: 690 -SWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRV 748
            SW P  ++     +  +Q    + LG +T   + + + G   S +   L P + Y   V
Sbjct: 757 VSWQPPPED---TQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEV 813

Query: 749 VATNPIGTGDPSTP 762
            A+   G+G  S P
Sbjct: 814 AASTGAGSGVKSEP 827


>gi|4506569 roundabout 1 isoform a [Homo sapiens]
          Length = 1651

 Score =  219 bits (558), Expect = 1e-56
 Identities = 225/855 (26%), Positives = 339/855 (39%), Gaps = 82/855 (9%)

Query: 96  DYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESD----YRYS 151
           D+ P  V+ P D+I    S  +   LNC+  G P P+  W + G  ++ + D    +R  
Sbjct: 65  DFPPRIVEHPSDLIV---SKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 121

Query: 152 LIDGTF----IISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSV 207
           L  G+     I+       D G Y C+A N +G  +S  A+L+ A L +   +  S V V
Sbjct: 122 LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 181

Query: 208 REGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSY 267
             G+  V+ C PP   PE   SW  +  P    +D    I+   G L I+  + SD G Y
Sbjct: 182 AVGEPAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIRGGKLMITYTRKSDAGKY 238

Query: 268 ICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGN 327
           +C+  N V      S    LT+         E    V  P  +      + + +C A G+
Sbjct: 239 VCVGTNMVGERE--SEVAELTV--------LERPSFVKRPSNLAVTVDDSAEFKCEARGD 288

Query: 328 PVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVY 387
           PVPT+ W K +G +P      +    L+I  V   D G Y C AEN  GK      L V 
Sbjct: 289 PVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 348

Query: 388 TYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNG--------VPLSPQSRVEM- 438
             PH+V K  D  +  G  + ++C+ATG P+P   W + G         P    SR  + 
Sbjct: 349 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 408

Query: 439 VNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELK---ILASAPTFALNQLKKTIIVTK 495
             G L I NV +SD G Y C   N  G+I   A L+   ++A  P   + Q      V  
Sbjct: 409 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 468

Query: 496 DQEVVIECKPQGSPKPTISWKK-GDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGE 554
           D   V+ C   GSP PTI W+K G     ++ RI  L +G L+I  A   D G+Y C   
Sbjct: 469 DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAS 528

Query: 555 NVFGSAEIIASLSVKE------------PTRIELTPKRTELT--VGESIVLNCKAIHDAS 600
              G A   A + V+E            P  I   P + E+T     ++ L+ +   ++ 
Sbjct: 529 TPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG 588

Query: 601 LDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRN----ILLMHAGRYG------- 649
              T Y                 E+++ + S+   +  N     L+  A  YG       
Sbjct: 589 ATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQI 648

Query: 650 ---CRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSP-ISSYN 705
               + Q    +        V+   G   + +      S++++      D  S  I  Y 
Sbjct: 649 SDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYK 708

Query: 706 LQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRV-VATNPIGTGDPSTPSR 764
           +  R   +   ++   V E+ T    S +  DL   V YE +     N     D  +  +
Sbjct: 709 ILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGAD--SEIK 766

Query: 765 MIRTNEAVPKTAP--TNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWK 822
             +T E  P   P    VS   G    ++++W+P  E+ QNG    Y V    N TR   
Sbjct: 767 FAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHI 826

Query: 823 EKMVTSSEASKFIYRDESVPPLTP---FEVKVGVYNNKGDGPFSQIVVI-CSAEGEPSAA 878
            K V  S  S  I      P L P   + V+V      G G  S+   I   A G P  +
Sbjct: 827 NKTVDGSTFSVVI------PFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNP-VS 879

Query: 879 PTDVKATSVSVSEIL 893
           P D  + +  +S+++
Sbjct: 880 PEDQVSLAQQISDVV 894



 Score =  175 bits (443), Expect = 2e-43
 Identities = 205/765 (26%), Positives = 303/765 (39%), Gaps = 106/765 (13%)

Query: 263 DVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMEC 322
           D G Y+C+ +N +  A   +    + +  D              P  V  A G    MEC
Sbjct: 141 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN---------PSDVMVAVGEPAVMEC 191

Query: 323 FA-LGNPVPTITWMKVNGYIPSK-ARLRKSQAVLEIPNVQLDDAGIYECRAENSRG-KNS 379
               G+P PTI+W K    +  K  R+      L I   +  DAG Y C   N  G + S
Sbjct: 192 QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 251

Query: 380 FRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMV 439
              +L V   P +V++ ++  +       ++C+A G P PT RW K+   L P+SR E+ 
Sbjct: 252 EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL-PKSRYEIR 310

Query: 440 NG-VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQE 498
           +   L I  V   D G Y C+AEN  G   ASA L +    P F +    +  +V   + 
Sbjct: 311 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV-QEPPHFVVKPRDQ--VVALGRT 367

Query: 499 VVIECKPQGSPKPTISWKKGD--------RAVRENKRIAILPDGSLRILNASKSDEGKYV 550
           V  +C+  G+P+P I W++          +  + + R ++   G L I N  +SD G Y+
Sbjct: 368 VTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYI 427

Query: 551 CRGENVFGSAEIIASLSVKE------PTRIELTPKRTELTVGESIVLNCKAIHDASLDVT 604
           C+  NV GS    A L V +      P  I   P    + V  + VL+C A    S   T
Sbjct: 428 CQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT--GSPVPT 485

Query: 605 FYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAE 664
             W   G  +  ++      S   Q  +  L IR   L   GRY C   T +   +  A 
Sbjct: 486 ILWRKDGVLVSTQD------SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAY 539

Query: 665 LLVRG------PPGP---------PGIVIVEEITESTATLSWSPAADNHSPISSYNLQAR 709
           + V+       PP P         P    V +++ +T TLSW P  ++ +  +SY ++A 
Sbjct: 540 IEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAF 599

Query: 710 SPFS-LGWQT----VKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSR 764
           S  S   WQT    VKT    I G         L P   Y F V A N  G  DPS  S 
Sbjct: 600 SHASGSSWQTVAENVKTETSAIKG---------LKPNAIYLFLVRAANAYGISDPSQISD 650

Query: 765 MIRTNEAVPKTA--------------------PTNVSGRSGRRHELVIAWEPVSEEFQNG 804
            ++T + +P +                     PT +S  S   H  V   +  S+  Q  
Sbjct: 651 PVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV---DQQSQYIQ-- 705

Query: 805 EGFGYIVAFRPNGTR----GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDG 860
              GY + +RP+G       W    V +   +  +  D  +     +E+K   + N+  G
Sbjct: 706 ---GYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPD--LRKGVNYEIKARPFFNEFQG 760

Query: 861 PFSQIVVICSAEGEPSAAP--TDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDME 918
             S+I    + E  PSA P    V     + + ILV+W+   E        E   W  + 
Sbjct: 761 ADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW-CLG 819

Query: 919 QEDTAETVKTRGNESF-VILTGLEGNTLYHFTVRAYNGAGYGPPS 962
            E      KT    +F V++  L     Y   V A  GAG G  S
Sbjct: 820 NETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKS 864



 Score =  158 bits (400), Expect = 2e-38
 Identities = 206/851 (24%), Positives = 338/851 (39%), Gaps = 106/851 (12%)

Query: 284  PTPLTLRNDGVMG---------EYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITW 334
            P P +  +D  +G         ++ P+I  H P  +  +KG    + C A G P PTI W
Sbjct: 43   PIPTSDNDDNSLGYTGSRLRQEDFPPRIVEH-PSDLIVSKGEPATLNCKAEGRPTPTIEW 101

Query: 335  MKVNGYIPSKARLRKSQAVLEIPNVQL------------DDAGIYECRAENSRGKN-SFR 381
             K    + +     +S  +L +P+  L             D G+Y C A N  G+  S  
Sbjct: 102  YKGGERVETDKDDPRSHRML-LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHN 160

Query: 382  GQLQVYTY-PHWVEKLNDTQLDSGSPLRWECKAT-GKPRPTYRWLKNGVPLSPQS-RVEM 438
              L+V      + +  +D  +  G P   EC+   G P PT  W K+G PL  +  R+ +
Sbjct: 161  ASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI 220

Query: 439  VNGVLMIHNVNQSDAGMYQCLAENKYGAIYAS-AELKILASAPTFALNQLKKTIIVTKDQ 497
              G LMI    +SDAG Y C+  N  G   +  AEL +L   P+F   +    + VT D 
Sbjct: 221  RGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL-ERPSFV--KRPSNLAVTVDD 277

Query: 498  EVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVF 557
                +C+ +G P PT+ W+K D  + ++ R  I  D +L+I   +  D G Y C  EN+ 
Sbjct: 278  SAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMV 336

Query: 558  GSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKG-QPIDF 616
            G AE  A+L+V+EP    + P+   + +G ++   C+A    +     +W  +G Q + F
Sbjct: 337  GKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEA--TGNPQPAIFWRREGSQNLLF 394

Query: 617  EEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRG--PPGPP 674
              +     S  + + + DL I N+     G Y C+    A S+  +A L V       PP
Sbjct: 395  SYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPP 454

Query: 675  GIVIVEEITESTA---TLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDME 731
             ++    + ++ A   T   S  A   SP+ +  L  +    +  Q  + + ++  G ++
Sbjct: 455  PVIRQGPVNQTVAVDGTFVLSCVATG-SPVPTI-LWRKDGVLVSTQDSR-IKQLENGVLQ 511

Query: 732  SAMAVDLNPWVEYEFRVVATNPIGT------------GDPSTPSRMIRTNEAVPKTAPTN 779
               A  L     Y    +A+ P G             G P  P R   T+  +  +AP+ 
Sbjct: 512  IRYA-KLGDTGRY--TCIASTPSGEATWSAYIEVQEFGVPVQPPR--PTDPNLIPSAPSK 566

Query: 780  VSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWK---EKMVTSSEASKFIY 836
                   R+ + ++W+P          +  I AF       W+   E + T + A K   
Sbjct: 567  PEVTDVSRNTVTLSWQPNLNSGATPTSY-IIEAFSHASGSSWQTVAENVKTETSAIK--- 622

Query: 837  RDESVPPLTPFEVKVGVYNNKGDGPFSQIV-VICSAEGEPSAAPTDVK------------ 883
                + P   +   V   N  G    SQI   + + +  P++   D K            
Sbjct: 623  ---GLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLH 679

Query: 884  ---ATSVSVSEILVAWKHIKES--------LGRPQGFEVGYWKDMEQEDTAETVKTRGNE 932
                T +S S I V W   ++S        L RP G   G     E +     V+T    
Sbjct: 680  LHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGANHG-----ESDWLVFEVRTPAKN 734

Query: 933  SFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNL---RWEQQGSQ 989
            S V++  L     Y    R +     G  S    A T +  PS  P  +   + +  G+ 
Sbjct: 735  S-VVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTA 793

Query: 990  VSLGWEPVIPLANESEVVGYKVFY--RQEGHSNSQVIETQKLQAVVPLPDAGV-YIIEVR 1046
            + + W+P         V  YKV+    +  +  ++ ++      V+P    G+ Y +EV 
Sbjct: 794  ILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVA 853

Query: 1047 AYSEGGDGTAS 1057
            A +  G G  S
Sbjct: 854  ASTGAGSGVKS 864



 Score =  129 bits (323), Expect = 2e-29
 Identities = 190/794 (23%), Positives = 312/794 (39%), Gaps = 113/794 (14%)

Query: 36  RIKKSSSSSLFGSKTRPRYSSPSLGTLSASSPSWLGAAQNYYSPINLYHSSDAFKQDESV 95
           R+   S S  F      R S P  G     + ++LG A ++ + + +    D F+Q+   
Sbjct: 119 RMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN--- 175

Query: 96  DYGPVFVQEPDDIIFPTDSDEKKVALNCE-VRGNPVPSYRWLRNGTEIDLESDYRYSLID 154
                    P D++       +   + C+  RG+P P+  W ++G+ +D + D R ++  
Sbjct: 176 ---------PSDVMVAVG---EPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITIRG 222

Query: 155 GTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGR-TRSAVSVREGQGV 213
           G  +I+  +   D+G Y C+ TN VG   S  A L      +F  R +  AV+V +    
Sbjct: 223 GKLMITY-TRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEF 281

Query: 214 VLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKN 273
                  P  P + +     E P        R+  ++   L I KV   D+GSY C+ +N
Sbjct: 282 KCEARGDP-VPTVRWRKDDGELP------KSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN 334

Query: 274 TVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTIT 333
            V  A        LT++        EP   V  P     A G TV  +C A GNP P I 
Sbjct: 335 MVGKAEA---SATLTVQ--------EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF 383

Query: 334 WMK------VNGYIP--SKARLRKSQ-AVLEIPNVQLDDAGIYECRAENSRGKNSFRGQL 384
           W +      +  Y P  S +R   SQ   L I NVQ  D G Y C+  N  G    +  L
Sbjct: 384 WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYL 443

Query: 385 QVYTY-----PHWVEK--LNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQ-SRV 436
           +V        P  + +  +N T    G+     C ATG P PT  W K+GV +S Q SR+
Sbjct: 444 EVTDVIADRPPPVIRQGPVNQTVAVDGT-FVLSCVATGSPVPTILWRKDGVLVSTQDSRI 502

Query: 437 -EMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKI-----------------LAS 478
            ++ NGVL I      D G Y C+A    G    SA +++                 + S
Sbjct: 503 KQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPS 562

Query: 479 APT--FALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGD--RAVRENKRIAILPDG 534
           AP+     +  + T+ ++    +     P        S   G   + V EN +       
Sbjct: 563 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTE----- 617

Query: 535 SLRILNASKSDEGKYVCRGENVFG---SAEIIASLSVKE--PTRIELTPKRTELTVGESI 589
           +  I     +    ++ R  N +G    ++I   +  ++  PT   +  K+ +  +G ++
Sbjct: 618 TSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAV 677

Query: 590 --VLNCKAIHDASLDVTFYWT-------LKGQPIDFEEEGGHFESIRAQASSADLMIRNI 640
             + N   +  +S++V  +WT       ++G  I +   G +               +N 
Sbjct: 678 LHLHNPTVLSSSSIEV--HWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNS 735

Query: 641 LLMHAGRYGCRVQTT----------ADSVSDEAELLVRGPPGPP-GIVIVEEITESTATL 689
           +++   R G   +            ADS    A+ L   P  PP G+ + +     TA L
Sbjct: 736 VVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAIL 795

Query: 690 -SWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRV 748
            SW P  ++     +  +Q    + LG +T   + + + G   S +   L P + Y   V
Sbjct: 796 VSWQPPPED---TQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEV 852

Query: 749 VATNPIGTGDPSTP 762
            A+   G+G  S P
Sbjct: 853 AASTGAGSGVKSEP 866


>gi|224994173 roundabout 1 isoform d [Homo sapiens]
          Length = 1551

 Score =  214 bits (545), Expect = 4e-55
 Identities = 225/858 (26%), Positives = 339/858 (39%), Gaps = 85/858 (9%)

Query: 96  DYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESD----YRYS 151
           D+ P  V+ P D+I    S  +   LNC+  G P P+  W + G  ++ + D    +R  
Sbjct: 26  DFPPRIVEHPSDLIV---SKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 82

Query: 152 LIDGTF----IISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSV 207
           L  G+     I+       D G Y C+A N +G  +S  A+L+ A L +   +  S V V
Sbjct: 83  LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 142

Query: 208 REGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSY 267
             G+  V+ C PP   PE   SW  +  P    +D    I+   G L I+  + SD G Y
Sbjct: 143 AVGEPAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIRGGKLMITYTRKSDAGKY 199

Query: 268 ICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGN 327
           +C+  N V      S    LT+         E    V  P  +      + + +C A G+
Sbjct: 200 VCVGTNMVGERE--SEVAELTV--------LERPSFVKRPSNLAVTVDDSAEFKCEARGD 249

Query: 328 PVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVY 387
           PVPT+ W K +G +P      +    L+I  V   D G Y C AEN  GK      L V 
Sbjct: 250 PVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309

Query: 388 T---YPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNG--------VPLSPQSRV 436
                PH+V K  D  +  G  + ++C+ATG P+P   W + G         P    SR 
Sbjct: 310 VGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 369

Query: 437 EM-VNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELK---ILASAPTFALNQLKKTII 492
            +   G L I NV +SD G Y C   N  G+I   A L+   ++A  P   + Q      
Sbjct: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429

Query: 493 VTKDQEVVIECKPQGSPKPTISWKK-GDRAVRENKRIAILPDGSLRILNASKSDEGKYVC 551
           V  D   V+ C   GSP PTI W+K G     ++ RI  L +G L+I  A   D G+Y C
Sbjct: 430 VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTC 489

Query: 552 RGENVFGSAEIIASLSVKE------------PTRIELTPKRTELT--VGESIVLNCKAIH 597
                 G A   A + V+E            P  I   P + E+T     ++ L+ +   
Sbjct: 490 IASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNL 549

Query: 598 DASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRN----ILLMHAGRYG---- 649
           ++    T Y                 E+++ + S+   +  N     L+  A  YG    
Sbjct: 550 NSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDP 609

Query: 650 ------CRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSP-IS 702
                  + Q    +        V+   G   + +      S++++      D  S  I 
Sbjct: 610 SQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQ 669

Query: 703 SYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRV-VATNPIGTGDPST 761
            Y +  R   +   ++   V E+ T    S +  DL   V YE +     N     D  +
Sbjct: 670 GYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGAD--S 727

Query: 762 PSRMIRTNEAVPKTAP--TNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTR 819
             +  +T E  P   P    VS   G    ++++W+P  E+ QNG    Y V    N TR
Sbjct: 728 EIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETR 787

Query: 820 GWKEKMVTSSEASKFIYRDESVPPLTP---FEVKVGVYNNKGDGPFSQIVVI-CSAEGEP 875
               K V  S  S  I      P L P   + V+V      G G  S+   I   A G P
Sbjct: 788 YHINKTVDGSTFSVVI------PFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNP 841

Query: 876 SAAPTDVKATSVSVSEIL 893
             +P D  + +  +S+++
Sbjct: 842 -VSPEDQVSLAQQISDVV 858



 Score =  175 bits (443), Expect = 2e-43
 Identities = 205/767 (26%), Positives = 304/767 (39%), Gaps = 107/767 (13%)

Query: 263 DVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMEC 322
           D G Y+C+ +N +  A   +    + +  D              P  V  A G    MEC
Sbjct: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN---------PSDVMVAVGEPAVMEC 152

Query: 323 FA-LGNPVPTITWMKVNGYIPSK-ARLRKSQAVLEIPNVQLDDAGIYECRAENSRG-KNS 379
               G+P PTI+W K    +  K  R+      L I   +  DAG Y C   N  G + S
Sbjct: 153 QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212

Query: 380 FRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMV 439
              +L V   P +V++ ++  +       ++C+A G P PT RW K+   L P+SR E+ 
Sbjct: 213 EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL-PKSRYEIR 271

Query: 440 NG-VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASA--PTFALNQLKKTIIVTKD 496
           +   L I  V   D G Y C+AEN  G   ASA L +   +  P F +    +  +V   
Sbjct: 272 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQ--VVALG 329

Query: 497 QEVVIECKPQGSPKPTISWKKGD--------RAVRENKRIAILPDGSLRILNASKSDEGK 548
           + V  +C+  G+P+P I W++          +  + + R ++   G L I N  +SD G 
Sbjct: 330 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 389

Query: 549 YVCRGENVFGSAEIIASLSVKE------PTRIELTPKRTELTVGESIVLNCKAIHDASLD 602
           Y+C+  NV GS    A L V +      P  I   P    + V  + VL+C A    S  
Sbjct: 390 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT--GSPV 447

Query: 603 VTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDE 662
            T  W   G  +  ++      S   Q  +  L IR   L   GRY C   T +   +  
Sbjct: 448 PTILWRKDGVLVSTQD------SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWS 501

Query: 663 AELLVRG------PPGP---------PGIVIVEEITESTATLSWSPAADNHSPISSYNLQ 707
           A + V+       PP P         P    V +++ +T TLSW P  ++ +  +SY ++
Sbjct: 502 AYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIE 561

Query: 708 ARSPFS-LGWQT----VKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTP 762
           A S  S   WQT    VKT    I G         L P   Y F V A N  G  DPS  
Sbjct: 562 AFSHASGSSWQTVAENVKTETSAIKG---------LKPNAIYLFLVRAANAYGISDPSQI 612

Query: 763 SRMIRTNEAVPKTA--------------------PTNVSGRSGRRHELVIAWEPVSEEFQ 802
           S  ++T + +P +                     PT +S  S   H  V   +  S+  Q
Sbjct: 613 SDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV---DQQSQYIQ 669

Query: 803 NGEGFGYIVAFRPNGTR----GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKG 858
                GY + +RP+G       W    V +   +  +  D  +     +E+K   + N+ 
Sbjct: 670 -----GYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPD--LRKGVNYEIKARPFFNEF 722

Query: 859 DGPFSQIVVICSAEGEPSAAP--TDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKD 916
            G  S+I    + E  PSA P    V     + + ILV+W+   E        E   W  
Sbjct: 723 QGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW-C 781

Query: 917 MEQEDTAETVKTRGNESF-VILTGLEGNTLYHFTVRAYNGAGYGPPS 962
           +  E      KT    +F V++  L     Y   V A  GAG G  S
Sbjct: 782 LGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKS 828



 Score =  129 bits (325), Expect = 1e-29
 Identities = 190/794 (23%), Positives = 311/794 (39%), Gaps = 110/794 (13%)

Query: 36  RIKKSSSSSLFGSKTRPRYSSPSLGTLSASSPSWLGAAQNYYSPINLYHSSDAFKQDESV 95
           R+   S S  F      R S P  G     + ++LG A ++ + + +    D F+Q+   
Sbjct: 80  RMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN--- 136

Query: 96  DYGPVFVQEPDDIIFPTDSDEKKVALNCE-VRGNPVPSYRWLRNGTEIDLESDYRYSLID 154
                    P D++       +   + C+  RG+P P+  W ++G+ +D + D R ++  
Sbjct: 137 ---------PSDVMVAVG---EPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITIRG 183

Query: 155 GTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGR-TRSAVSVREGQGV 213
           G  +I+  +   D+G Y C+ TN VG   S  A L      +F  R +  AV+V +    
Sbjct: 184 GKLMITY-TRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEF 242

Query: 214 VLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKN 273
                  P  P + +     E P        R+  ++   L I KV   D+GSY C+ +N
Sbjct: 243 KCEARGDP-VPTVRWRKDDGELP------KSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN 295

Query: 274 TVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTIT 333
            V  A   +  T        V    EP   V  P     A G TV  +C A GNP P I 
Sbjct: 296 MVGKAEASATLT--------VQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF 347

Query: 334 WMK------VNGYIP--SKARLRKSQ-AVLEIPNVQLDDAGIYECRAENSRGKNSFRGQL 384
           W +      +  Y P  S +R   SQ   L I NVQ  D G Y C+  N  G    +  L
Sbjct: 348 WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYL 407

Query: 385 QVYTY-----PHWVEK--LNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQ-SRV 436
           +V        P  + +  +N T    G+     C ATG P PT  W K+GV +S Q SR+
Sbjct: 408 EVTDVIADRPPPVIRQGPVNQTVAVDGT-FVLSCVATGSPVPTILWRKDGVLVSTQDSRI 466

Query: 437 -EMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKI-----------------LAS 478
            ++ NGVL I      D G Y C+A    G    SA +++                 + S
Sbjct: 467 KQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPS 526

Query: 479 APT--FALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGD--RAVRENKRIAILPDG 534
           AP+     +  + T+ ++    +     P        S   G   + V EN +       
Sbjct: 527 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTE----- 581

Query: 535 SLRILNASKSDEGKYVCRGENVFG---SAEIIASLSVKE--PTRIELTPKRTELTVGESI 589
           +  I     +    ++ R  N +G    ++I   +  ++  PT   +  K+ +  +G ++
Sbjct: 582 TSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAV 641

Query: 590 --VLNCKAIHDASLDVTFYWT-------LKGQPIDFEEEGGHFESIRAQASSADLMIRNI 640
             + N   +  +S++V  +WT       ++G  I +   G +               +N 
Sbjct: 642 LHLHNPTVLSSSSIEV--HWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNS 699

Query: 641 LLMHAGRYGCRVQTT----------ADSVSDEAELLVRGPPGPP-GIVIVEEITESTATL 689
           +++   R G   +            ADS    A+ L   P  PP G+ + +     TA L
Sbjct: 700 VVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAIL 759

Query: 690 -SWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRV 748
            SW P  ++     +  +Q    + LG +T   + + + G   S +   L P + Y   V
Sbjct: 760 VSWQPPPED---TQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEV 816

Query: 749 VATNPIGTGDPSTP 762
            A+   G+G  S P
Sbjct: 817 AASTGAGSGVKSEP 830


>gi|224994171 roundabout 1 isoform c [Homo sapiens]
          Length = 1606

 Score =  214 bits (545), Expect = 4e-55
 Identities = 225/858 (26%), Positives = 339/858 (39%), Gaps = 85/858 (9%)

Query: 96  DYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESD----YRYS 151
           D+ P  V+ P D+I    S  +   LNC+  G P P+  W + G  ++ + D    +R  
Sbjct: 26  DFPPRIVEHPSDLIV---SKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 82

Query: 152 LIDGTF----IISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSV 207
           L  G+     I+       D G Y C+A N +G  +S  A+L+ A L +   +  S V V
Sbjct: 83  LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 142

Query: 208 REGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSY 267
             G+  V+ C PP   PE   SW  +  P    +D    I+   G L I+  + SD G Y
Sbjct: 143 AVGEPAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIRGGKLMITYTRKSDAGKY 199

Query: 268 ICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGN 327
           +C+  N V      S    LT+         E    V  P  +      + + +C A G+
Sbjct: 200 VCVGTNMVGERE--SEVAELTV--------LERPSFVKRPSNLAVTVDDSAEFKCEARGD 249

Query: 328 PVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVY 387
           PVPT+ W K +G +P      +    L+I  V   D G Y C AEN  GK      L V 
Sbjct: 250 PVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309

Query: 388 T---YPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNG--------VPLSPQSRV 436
                PH+V K  D  +  G  + ++C+ATG P+P   W + G         P    SR 
Sbjct: 310 VGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 369

Query: 437 EM-VNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELK---ILASAPTFALNQLKKTII 492
            +   G L I NV +SD G Y C   N  G+I   A L+   ++A  P   + Q      
Sbjct: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429

Query: 493 VTKDQEVVIECKPQGSPKPTISWKK-GDRAVRENKRIAILPDGSLRILNASKSDEGKYVC 551
           V  D   V+ C   GSP PTI W+K G     ++ RI  L +G L+I  A   D G+Y C
Sbjct: 430 VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTC 489

Query: 552 RGENVFGSAEIIASLSVKE------------PTRIELTPKRTELT--VGESIVLNCKAIH 597
                 G A   A + V+E            P  I   P + E+T     ++ L+ +   
Sbjct: 490 IASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNL 549

Query: 598 DASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRN----ILLMHAGRYG---- 649
           ++    T Y                 E+++ + S+   +  N     L+  A  YG    
Sbjct: 550 NSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDP 609

Query: 650 ------CRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSP-IS 702
                  + Q    +        V+   G   + +      S++++      D  S  I 
Sbjct: 610 SQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQ 669

Query: 703 SYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRV-VATNPIGTGDPST 761
            Y +  R   +   ++   V E+ T    S +  DL   V YE +     N     D  +
Sbjct: 670 GYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGAD--S 727

Query: 762 PSRMIRTNEAVPKTAP--TNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTR 819
             +  +T E  P   P    VS   G    ++++W+P  E+ QNG    Y V    N TR
Sbjct: 728 EIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETR 787

Query: 820 GWKEKMVTSSEASKFIYRDESVPPLTP---FEVKVGVYNNKGDGPFSQIVVI-CSAEGEP 875
               K V  S  S  I      P L P   + V+V      G G  S+   I   A G P
Sbjct: 788 YHINKTVDGSTFSVVI------PFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNP 841

Query: 876 SAAPTDVKATSVSVSEIL 893
             +P D  + +  +S+++
Sbjct: 842 -VSPEDQVSLAQQISDVV 858



 Score =  175 bits (443), Expect = 2e-43
 Identities = 205/767 (26%), Positives = 304/767 (39%), Gaps = 107/767 (13%)

Query: 263 DVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMEC 322
           D G Y+C+ +N +  A   +    + +  D              P  V  A G    MEC
Sbjct: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN---------PSDVMVAVGEPAVMEC 152

Query: 323 FA-LGNPVPTITWMKVNGYIPSK-ARLRKSQAVLEIPNVQLDDAGIYECRAENSRG-KNS 379
               G+P PTI+W K    +  K  R+      L I   +  DAG Y C   N  G + S
Sbjct: 153 QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212

Query: 380 FRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMV 439
              +L V   P +V++ ++  +       ++C+A G P PT RW K+   L P+SR E+ 
Sbjct: 213 EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL-PKSRYEIR 271

Query: 440 NG-VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASA--PTFALNQLKKTIIVTKD 496
           +   L I  V   D G Y C+AEN  G   ASA L +   +  P F +    +  +V   
Sbjct: 272 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQ--VVALG 329

Query: 497 QEVVIECKPQGSPKPTISWKKGD--------RAVRENKRIAILPDGSLRILNASKSDEGK 548
           + V  +C+  G+P+P I W++          +  + + R ++   G L I N  +SD G 
Sbjct: 330 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 389

Query: 549 YVCRGENVFGSAEIIASLSVKE------PTRIELTPKRTELTVGESIVLNCKAIHDASLD 602
           Y+C+  NV GS    A L V +      P  I   P    + V  + VL+C A    S  
Sbjct: 390 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT--GSPV 447

Query: 603 VTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDE 662
            T  W   G  +  ++      S   Q  +  L IR   L   GRY C   T +   +  
Sbjct: 448 PTILWRKDGVLVSTQD------SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWS 501

Query: 663 AELLVRG------PPGP---------PGIVIVEEITESTATLSWSPAADNHSPISSYNLQ 707
           A + V+       PP P         P    V +++ +T TLSW P  ++ +  +SY ++
Sbjct: 502 AYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIE 561

Query: 708 ARSPFS-LGWQT----VKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTP 762
           A S  S   WQT    VKT    I G         L P   Y F V A N  G  DPS  
Sbjct: 562 AFSHASGSSWQTVAENVKTETSAIKG---------LKPNAIYLFLVRAANAYGISDPSQI 612

Query: 763 SRMIRTNEAVPKTA--------------------PTNVSGRSGRRHELVIAWEPVSEEFQ 802
           S  ++T + +P +                     PT +S  S   H  V   +  S+  Q
Sbjct: 613 SDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV---DQQSQYIQ 669

Query: 803 NGEGFGYIVAFRPNGTR----GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKG 858
                GY + +RP+G       W    V +   +  +  D  +     +E+K   + N+ 
Sbjct: 670 -----GYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPD--LRKGVNYEIKARPFFNEF 722

Query: 859 DGPFSQIVVICSAEGEPSAAP--TDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKD 916
            G  S+I    + E  PSA P    V     + + ILV+W+   E        E   W  
Sbjct: 723 QGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW-C 781

Query: 917 MEQEDTAETVKTRGNESF-VILTGLEGNTLYHFTVRAYNGAGYGPPS 962
           +  E      KT    +F V++  L     Y   V A  GAG G  S
Sbjct: 782 LGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKS 828



 Score =  129 bits (325), Expect = 1e-29
 Identities = 190/794 (23%), Positives = 311/794 (39%), Gaps = 110/794 (13%)

Query: 36  RIKKSSSSSLFGSKTRPRYSSPSLGTLSASSPSWLGAAQNYYSPINLYHSSDAFKQDESV 95
           R+   S S  F      R S P  G     + ++LG A ++ + + +    D F+Q+   
Sbjct: 80  RMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN--- 136

Query: 96  DYGPVFVQEPDDIIFPTDSDEKKVALNCE-VRGNPVPSYRWLRNGTEIDLESDYRYSLID 154
                    P D++       +   + C+  RG+P P+  W ++G+ +D + D R ++  
Sbjct: 137 ---------PSDVMVAVG---EPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITIRG 183

Query: 155 GTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGR-TRSAVSVREGQGV 213
           G  +I+  +   D+G Y C+ TN VG   S  A L      +F  R +  AV+V +    
Sbjct: 184 GKLMITY-TRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEF 242

Query: 214 VLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKN 273
                  P  P + +     E P        R+  ++   L I KV   D+GSY C+ +N
Sbjct: 243 KCEARGDP-VPTVRWRKDDGELP------KSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN 295

Query: 274 TVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTIT 333
            V  A   +  T        V    EP   V  P     A G TV  +C A GNP P I 
Sbjct: 296 MVGKAEASATLT--------VQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF 347

Query: 334 WMK------VNGYIP--SKARLRKSQ-AVLEIPNVQLDDAGIYECRAENSRGKNSFRGQL 384
           W +      +  Y P  S +R   SQ   L I NVQ  D G Y C+  N  G    +  L
Sbjct: 348 WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYL 407

Query: 385 QVYTY-----PHWVEK--LNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQ-SRV 436
           +V        P  + +  +N T    G+     C ATG P PT  W K+GV +S Q SR+
Sbjct: 408 EVTDVIADRPPPVIRQGPVNQTVAVDGT-FVLSCVATGSPVPTILWRKDGVLVSTQDSRI 466

Query: 437 -EMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKI-----------------LAS 478
            ++ NGVL I      D G Y C+A    G    SA +++                 + S
Sbjct: 467 KQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPS 526

Query: 479 APT--FALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGD--RAVRENKRIAILPDG 534
           AP+     +  + T+ ++    +     P        S   G   + V EN +       
Sbjct: 527 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTE----- 581

Query: 535 SLRILNASKSDEGKYVCRGENVFG---SAEIIASLSVKE--PTRIELTPKRTELTVGESI 589
           +  I     +    ++ R  N +G    ++I   +  ++  PT   +  K+ +  +G ++
Sbjct: 582 TSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAV 641

Query: 590 --VLNCKAIHDASLDVTFYWT-------LKGQPIDFEEEGGHFESIRAQASSADLMIRNI 640
             + N   +  +S++V  +WT       ++G  I +   G +               +N 
Sbjct: 642 LHLHNPTVLSSSSIEV--HWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNS 699

Query: 641 LLMHAGRYGCRVQTT----------ADSVSDEAELLVRGPPGPP-GIVIVEEITESTATL 689
           +++   R G   +            ADS    A+ L   P  PP G+ + +     TA L
Sbjct: 700 VVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAIL 759

Query: 690 -SWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRV 748
            SW P  ++     +  +Q    + LG +T   + + + G   S +   L P + Y   V
Sbjct: 760 VSWQPPPED---TQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEV 816

Query: 749 VATNPIGTGDPSTP 762
            A+   G+G  S P
Sbjct: 817 AASTGAGSGVKSEP 830


>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
           sapiens]
          Length = 1562

 Score =  214 bits (545), Expect = 4e-55
 Identities = 225/858 (26%), Positives = 339/858 (39%), Gaps = 85/858 (9%)

Query: 96  DYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESD----YRYS 151
           D+ P  V+ P D+I    S  +   LNC+  G P P+  W + G  ++ + D    +R  
Sbjct: 26  DFPPRIVEHPSDLIV---SKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 82

Query: 152 LIDGTF----IISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSV 207
           L  G+     I+       D G Y C+A N +G  +S  A+L+ A L +   +  S V V
Sbjct: 83  LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 142

Query: 208 REGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSY 267
             G+  V+ C PP   PE   SW  +  P    +D    I+   G L I+  + SD G Y
Sbjct: 143 AVGEPAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIRGGKLMITYTRKSDAGKY 199

Query: 268 ICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGN 327
           +C+  N V      S    LT+         E    V  P  +      + + +C A G+
Sbjct: 200 VCVGTNMVGERE--SEVAELTV--------LERPSFVKRPSNLAVTVDDSAEFKCEARGD 249

Query: 328 PVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVY 387
           PVPT+ W K +G +P      +    L+I  V   D G Y C AEN  GK      L V 
Sbjct: 250 PVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309

Query: 388 T---YPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNG--------VPLSPQSRV 436
                PH+V K  D  +  G  + ++C+ATG P+P   W + G         P    SR 
Sbjct: 310 VGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 369

Query: 437 EM-VNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELK---ILASAPTFALNQLKKTII 492
            +   G L I NV +SD G Y C   N  G+I   A L+   ++A  P   + Q      
Sbjct: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429

Query: 493 VTKDQEVVIECKPQGSPKPTISWKK-GDRAVRENKRIAILPDGSLRILNASKSDEGKYVC 551
           V  D   V+ C   GSP PTI W+K G     ++ RI  L +G L+I  A   D G+Y C
Sbjct: 430 VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTC 489

Query: 552 RGENVFGSAEIIASLSVKE------------PTRIELTPKRTELT--VGESIVLNCKAIH 597
                 G A   A + V+E            P  I   P + E+T     ++ L+ +   
Sbjct: 490 IASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNL 549

Query: 598 DASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRN----ILLMHAGRYG---- 649
           ++    T Y                 E+++ + S+   +  N     L+  A  YG    
Sbjct: 550 NSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDP 609

Query: 650 ------CRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSP-IS 702
                  + Q    +        V+   G   + +      S++++      D  S  I 
Sbjct: 610 SQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQ 669

Query: 703 SYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRV-VATNPIGTGDPST 761
            Y +  R   +   ++   V E+ T    S +  DL   V YE +     N     D  +
Sbjct: 670 GYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGAD--S 727

Query: 762 PSRMIRTNEAVPKTAP--TNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTR 819
             +  +T E  P   P    VS   G    ++++W+P  E+ QNG    Y V    N TR
Sbjct: 728 EIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETR 787

Query: 820 GWKEKMVTSSEASKFIYRDESVPPLTP---FEVKVGVYNNKGDGPFSQIVVI-CSAEGEP 875
               K V  S  S  I      P L P   + V+V      G G  S+   I   A G P
Sbjct: 788 YHINKTVDGSTFSVVI------PFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNP 841

Query: 876 SAAPTDVKATSVSVSEIL 893
             +P D  + +  +S+++
Sbjct: 842 -VSPEDQVSLAQQISDVV 858



 Score =  175 bits (443), Expect = 2e-43
 Identities = 205/767 (26%), Positives = 304/767 (39%), Gaps = 107/767 (13%)

Query: 263 DVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMEC 322
           D G Y+C+ +N +  A   +    + +  D              P  V  A G    MEC
Sbjct: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN---------PSDVMVAVGEPAVMEC 152

Query: 323 FA-LGNPVPTITWMKVNGYIPSK-ARLRKSQAVLEIPNVQLDDAGIYECRAENSRG-KNS 379
               G+P PTI+W K    +  K  R+      L I   +  DAG Y C   N  G + S
Sbjct: 153 QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212

Query: 380 FRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMV 439
              +L V   P +V++ ++  +       ++C+A G P PT RW K+   L P+SR E+ 
Sbjct: 213 EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL-PKSRYEIR 271

Query: 440 NG-VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASA--PTFALNQLKKTIIVTKD 496
           +   L I  V   D G Y C+AEN  G   ASA L +   +  P F +    +  +V   
Sbjct: 272 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQ--VVALG 329

Query: 497 QEVVIECKPQGSPKPTISWKKGD--------RAVRENKRIAILPDGSLRILNASKSDEGK 548
           + V  +C+  G+P+P I W++          +  + + R ++   G L I N  +SD G 
Sbjct: 330 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 389

Query: 549 YVCRGENVFGSAEIIASLSVKE------PTRIELTPKRTELTVGESIVLNCKAIHDASLD 602
           Y+C+  NV GS    A L V +      P  I   P    + V  + VL+C A    S  
Sbjct: 390 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT--GSPV 447

Query: 603 VTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDE 662
            T  W   G  +  ++      S   Q  +  L IR   L   GRY C   T +   +  
Sbjct: 448 PTILWRKDGVLVSTQD------SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWS 501

Query: 663 AELLVRG------PPGP---------PGIVIVEEITESTATLSWSPAADNHSPISSYNLQ 707
           A + V+       PP P         P    V +++ +T TLSW P  ++ +  +SY ++
Sbjct: 502 AYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIE 561

Query: 708 ARSPFS-LGWQT----VKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTP 762
           A S  S   WQT    VKT    I G         L P   Y F V A N  G  DPS  
Sbjct: 562 AFSHASGSSWQTVAENVKTETSAIKG---------LKPNAIYLFLVRAANAYGISDPSQI 612

Query: 763 SRMIRTNEAVPKTA--------------------PTNVSGRSGRRHELVIAWEPVSEEFQ 802
           S  ++T + +P +                     PT +S  S   H  V   +  S+  Q
Sbjct: 613 SDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV---DQQSQYIQ 669

Query: 803 NGEGFGYIVAFRPNGTR----GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKG 858
                GY + +RP+G       W    V +   +  +  D  +     +E+K   + N+ 
Sbjct: 670 -----GYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPD--LRKGVNYEIKARPFFNEF 722

Query: 859 DGPFSQIVVICSAEGEPSAAP--TDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKD 916
            G  S+I    + E  PSA P    V     + + ILV+W+   E        E   W  
Sbjct: 723 QGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW-C 781

Query: 917 MEQEDTAETVKTRGNESF-VILTGLEGNTLYHFTVRAYNGAGYGPPS 962
           +  E      KT    +F V++  L     Y   V A  GAG G  S
Sbjct: 782 LGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKS 828



 Score =  129 bits (325), Expect = 1e-29
 Identities = 190/794 (23%), Positives = 311/794 (39%), Gaps = 110/794 (13%)

Query: 36  RIKKSSSSSLFGSKTRPRYSSPSLGTLSASSPSWLGAAQNYYSPINLYHSSDAFKQDESV 95
           R+   S S  F      R S P  G     + ++LG A ++ + + +    D F+Q+   
Sbjct: 80  RMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN--- 136

Query: 96  DYGPVFVQEPDDIIFPTDSDEKKVALNCE-VRGNPVPSYRWLRNGTEIDLESDYRYSLID 154
                    P D++       +   + C+  RG+P P+  W ++G+ +D + D R ++  
Sbjct: 137 ---------PSDVMVAVG---EPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITIRG 183

Query: 155 GTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGR-TRSAVSVREGQGV 213
           G  +I+  +   D+G Y C+ TN VG   S  A L      +F  R +  AV+V +    
Sbjct: 184 GKLMITY-TRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEF 242

Query: 214 VLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKN 273
                  P  P + +     E P        R+  ++   L I KV   D+GSY C+ +N
Sbjct: 243 KCEARGDP-VPTVRWRKDDGELP------KSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN 295

Query: 274 TVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTIT 333
            V  A   +  T        V    EP   V  P     A G TV  +C A GNP P I 
Sbjct: 296 MVGKAEASATLT--------VQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF 347

Query: 334 WMK------VNGYIP--SKARLRKSQ-AVLEIPNVQLDDAGIYECRAENSRGKNSFRGQL 384
           W +      +  Y P  S +R   SQ   L I NVQ  D G Y C+  N  G    +  L
Sbjct: 348 WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYL 407

Query: 385 QVYTY-----PHWVEK--LNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQ-SRV 436
           +V        P  + +  +N T    G+     C ATG P PT  W K+GV +S Q SR+
Sbjct: 408 EVTDVIADRPPPVIRQGPVNQTVAVDGT-FVLSCVATGSPVPTILWRKDGVLVSTQDSRI 466

Query: 437 -EMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKI-----------------LAS 478
            ++ NGVL I      D G Y C+A    G    SA +++                 + S
Sbjct: 467 KQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPS 526

Query: 479 APT--FALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGD--RAVRENKRIAILPDG 534
           AP+     +  + T+ ++    +     P        S   G   + V EN +       
Sbjct: 527 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTE----- 581

Query: 535 SLRILNASKSDEGKYVCRGENVFG---SAEIIASLSVKE--PTRIELTPKRTELTVGESI 589
           +  I     +    ++ R  N +G    ++I   +  ++  PT   +  K+ +  +G ++
Sbjct: 582 TSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAV 641

Query: 590 --VLNCKAIHDASLDVTFYWT-------LKGQPIDFEEEGGHFESIRAQASSADLMIRNI 640
             + N   +  +S++V  +WT       ++G  I +   G +               +N 
Sbjct: 642 LHLHNPTVLSSSSIEV--HWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNS 699

Query: 641 LLMHAGRYGCRVQTT----------ADSVSDEAELLVRGPPGPP-GIVIVEEITESTATL 689
           +++   R G   +            ADS    A+ L   P  PP G+ + +     TA L
Sbjct: 700 VVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAIL 759

Query: 690 -SWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRV 748
            SW P  ++     +  +Q    + LG +T   + + + G   S +   L P + Y   V
Sbjct: 760 VSWQPPPED---TQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEV 816

Query: 749 VATNPIGTGDPSTP 762
            A+   G+G  S P
Sbjct: 817 AASTGAGSGVKSEP 830


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.130    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,748,505
Number of Sequences: 37866
Number of extensions: 2156694
Number of successful extensions: 17345
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 291
Number of HSP's successfully gapped in prelim test: 234
Number of HSP's that attempted gapping in prelim test: 5487
Number of HSP's gapped (non-prelim): 4263
length of query: 1100
length of database: 18,247,518
effective HSP length: 113
effective length of query: 987
effective length of database: 13,968,660
effective search space: 13787067420
effective search space used: 13787067420
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.