Guide to the Human Genome
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Search of human proteins with 73532778

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|73532778 casein kinase 1, gamma 3 isoform 1 [Homo sapiens]
         (447 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|73532778 casein kinase 1, gamma 3 isoform 1 [Homo sapiens]         924   0.0  
gi|113462010 casein kinase 1, gamma 3 isoform 4 [Homo sapiens]        914   0.0  
gi|113462008 casein kinase 1, gamma 3 isoform 3 [Homo sapiens]        839   0.0  
gi|73532780 casein kinase 1, gamma 3 isoform 2 [Homo sapiens]         830   0.0  
gi|153791733 casein kinase 1, gamma 2 [Homo sapiens]                  686   0.0  
gi|98986450 casein kinase 1, gamma 1 [Homo sapiens]                   684   0.0  
gi|23199991 casein kinase 1 epsilon [Homo sapiens]                    367   e-102
gi|4503093 casein kinase 1 epsilon [Homo sapiens]                     367   e-102
gi|20544145 casein kinase 1, delta isoform 2 [Homo sapiens]           360   1e-99
gi|20149530 casein kinase 1, delta isoform 1 [Homo sapiens]           360   1e-99
gi|68303572 casein kinase 1, alpha 1 isoform 2 [Homo sapiens]         332   5e-91
gi|68303575 casein kinase 1, alpha 1 isoform 1 [Homo sapiens]         323   3e-88
gi|21624639 casein kinase 1, alpha 1-like [Homo sapiens]              321   1e-87
gi|58761548 tau tubulin kinase 1 [Homo sapiens]                       154   1e-37
gi|116812624 tau tubulin kinase 2 [Homo sapiens]                      148   1e-35
gi|4507903 vaccinia related kinase 1 [Homo sapiens]                   117   3e-26
gi|194440713 vaccinia related kinase 2 isoform 3 [Homo sapiens]       108   1e-23
gi|194440711 vaccinia related kinase 2 isoform 2 [Homo sapiens]       108   1e-23
gi|194440709 vaccinia related kinase 2 isoform 1 [Homo sapiens]       108   1e-23
gi|194440707 vaccinia related kinase 2 isoform 1 [Homo sapiens]       108   1e-23
gi|71164884 vaccinia related kinase 2 isoform 1 [Homo sapiens]        108   1e-23
gi|209862855 vaccinia related kinase 2 isoform 6 [Homo sapiens]        95   1e-19
gi|71164888 vaccinia related kinase 3 isoform 2 [Homo sapiens]         82   1e-15
gi|71164886 vaccinia related kinase 3 isoform 1 [Homo sapiens]         82   1e-15
gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform...    71   2e-12
gi|239756427 PREDICTED: similar to 3-phosphoinositide dependent ...    71   2e-12
gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo ...    71   2e-12
gi|38327572 serine/threonine protein kinase 6 [Homo sapiens]           69   9e-12
gi|38327570 serine/threonine protein kinase 6 [Homo sapiens]           69   9e-12
gi|38327568 serine/threonine protein kinase 6 [Homo sapiens]           69   9e-12

>gi|73532778 casein kinase 1, gamma 3 isoform 1 [Homo sapiens]
          Length = 447

 Score =  924 bits (2387), Expect = 0.0
 Identities = 447/447 (100%), Positives = 447/447 (100%)

Query: 1   MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLG 60
           MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLG
Sbjct: 1   MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLG 60

Query: 61  KNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLG 120
           KNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLG
Sbjct: 61  KNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLG 120

Query: 121 PSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQV 180
           PSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQV
Sbjct: 121 PSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQV 180

Query: 181 IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM 240
           IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM
Sbjct: 181 IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM 240

Query: 241 YFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPD 300
           YFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPD
Sbjct: 241 YFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPD 300

Query: 301 YDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSK 360
           YDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSK
Sbjct: 301 YDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSK 360

Query: 361 NQSADHRAAWDSQQANPHHLRAHLAADRHGGSVQVVSSTNGELNTDDPTAGRSNAPITAP 420
           NQSADHRAAWDSQQANPHHLRAHLAADRHGGSVQVVSSTNGELNTDDPTAGRSNAPITAP
Sbjct: 361 NQSADHRAAWDSQQANPHHLRAHLAADRHGGSVQVVSSTNGELNTDDPTAGRSNAPITAP 420

Query: 421 TEVEVMDETKCCCFFKRRKRKTIQRHK 447
           TEVEVMDETKCCCFFKRRKRKTIQRHK
Sbjct: 421 TEVEVMDETKCCCFFKRRKRKTIQRHK 447


>gi|113462010 casein kinase 1, gamma 3 isoform 4 [Homo sapiens]
          Length = 455

 Score =  914 bits (2363), Expect = 0.0
 Identities = 446/455 (98%), Positives = 446/455 (98%), Gaps = 8/455 (1%)

Query: 1   MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLG 60
           MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLG
Sbjct: 1   MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLG 60

Query: 61  KNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLG 120
           KNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLG
Sbjct: 61  KNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLG 120

Query: 121 PSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQV 180
           PSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQV
Sbjct: 121 PSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQV 180

Query: 181 IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM 240
           IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM
Sbjct: 181 IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM 240

Query: 241 YFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPD 300
           YFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPD
Sbjct: 241 YFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPD 300

Query: 301 YDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSK 360
           YDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSK
Sbjct: 301 YDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSK 360

Query: 361 NQSADHRAAWDSQQANPHHLRAHLAADRHGGSVQVVSSTNGELNTDDPTAGRSNAPITAP 420
           NQSADHRAAWDSQQANPHHLRAHLAADRHGGSVQVVSSTNGELNTDDPTAGRSNAPITAP
Sbjct: 361 NQSADHRAAWDSQQANPHHLRAHLAADRHGGSVQVVSSTNGELNTDDPTAGRSNAPITAP 420

Query: 421 TEVEVMDETK--------CCCFFKRRKRKTIQRHK 447
           TEVEVMDET         CCCFFKRRKRKTIQRHK
Sbjct: 421 TEVEVMDETNCQKVLNMWCCCFFKRRKRKTIQRHK 455


>gi|113462008 casein kinase 1, gamma 3 isoform 3 [Homo sapiens]
          Length = 415

 Score =  839 bits (2168), Expect = 0.0
 Identities = 415/447 (92%), Positives = 415/447 (92%), Gaps = 32/447 (7%)

Query: 1   MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLG 60
           MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLG
Sbjct: 1   MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLG 60

Query: 61  KNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLG 120
           KNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLG
Sbjct: 61  KNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLG 120

Query: 121 PSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQV 180
           PSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQV
Sbjct: 121 PSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQV 180

Query: 181 IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM 240
           IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM
Sbjct: 181 IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM 240

Query: 241 YFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPD 300
           YFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPD
Sbjct: 241 YFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPD 300

Query: 301 YDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSK 360
           YDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSK
Sbjct: 301 YDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSK 360

Query: 361 NQSADHRAAWDSQQANPHHLRAHLAADRHGGSVQVVSSTNGELNTDDPTAGRSNAPITAP 420
           NQ                                VVSSTNGELNTDDPTAGRSNAPITAP
Sbjct: 361 NQ--------------------------------VVSSTNGELNTDDPTAGRSNAPITAP 388

Query: 421 TEVEVMDETKCCCFFKRRKRKTIQRHK 447
           TEVEVMDETKCCCFFKRRKRKTIQRHK
Sbjct: 389 TEVEVMDETKCCCFFKRRKRKTIQRHK 415


>gi|73532780 casein kinase 1, gamma 3 isoform 2 [Homo sapiens]
          Length = 423

 Score =  830 bits (2144), Expect = 0.0
 Identities = 414/455 (90%), Positives = 414/455 (90%), Gaps = 40/455 (8%)

Query: 1   MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLG 60
           MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLG
Sbjct: 1   MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLG 60

Query: 61  KNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLG 120
           KNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLG
Sbjct: 61  KNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLG 120

Query: 121 PSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQV 180
           PSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQV
Sbjct: 121 PSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQV 180

Query: 181 IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM 240
           IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM
Sbjct: 181 IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM 240

Query: 241 YFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPD 300
           YFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPD
Sbjct: 241 YFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPD 300

Query: 301 YDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSK 360
           YDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSK
Sbjct: 301 YDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSK 360

Query: 361 NQSADHRAAWDSQQANPHHLRAHLAADRHGGSVQVVSSTNGELNTDDPTAGRSNAPITAP 420
           N                                QVVSSTNGELNTDDPTAGRSNAPITAP
Sbjct: 361 N--------------------------------QVVSSTNGELNTDDPTAGRSNAPITAP 388

Query: 421 TEVEVMDETK--------CCCFFKRRKRKTIQRHK 447
           TEVEVMDET         CCCFFKRRKRKTIQRHK
Sbjct: 389 TEVEVMDETNCQKVLNMWCCCFFKRRKRKTIQRHK 423


>gi|153791733 casein kinase 1, gamma 2 [Homo sapiens]
          Length = 415

 Score =  686 bits (1770), Expect = 0.0
 Identities = 350/450 (77%), Positives = 376/450 (83%), Gaps = 43/450 (9%)

Query: 3   NKKKDKDKSDD--RMARPSG-RSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRL 59
           +KK  K ++++  RM++  G RS H  R +G+SS GVLMVGPNFRVGKKIGCGNFGELRL
Sbjct: 4   DKKGGKGETEEGRRMSKAGGGRSSHGIRSSGTSS-GVLMVGPNFRVGKKIGCGNFGELRL 62

Query: 60  GKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELL 119
           GKNLYTNEYVAIKLEP+KSRAPQLHLEYRFYKQL + +G+PQVYYFGPCGKYNAMVLELL
Sbjct: 63  GKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYYFGPCGKYNAMVLELL 122

Query: 120 GPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQ 179
           GPSLEDLFDLCDRTF+LKTVLMIAIQLI+RMEYVH+K+LIYRDVKPENFL+GRPG K Q 
Sbjct: 123 GPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQH 182

Query: 180 VIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMF 239
            IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMF
Sbjct: 183 AIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMF 242

Query: 240 MYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFP-EMATYLRYVRRLDFFEK 298
           MYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFP EMATYLRYVRRLDFFEK
Sbjct: 243 MYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEK 302

Query: 299 PDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQ- 357
           PDYDYLRKLFTDLFDR G++FDYEYDW GK LPTP+G V  D  L S     Q RDK Q 
Sbjct: 303 PDYDYLRKLFTDLFDRSGFVFDYEYDWAGKPLPTPIGTVHTD--LPSQ---PQLRDKTQP 357

Query: 358 QSKNQSADHRAAWDSQQANPHHLRAHLAADRHGGSVQVVSSTNGELNTDDPTAGRSNAPI 417
            SKNQ+                                ++STNGELN DDPTAG SNAPI
Sbjct: 358 HSKNQA--------------------------------LNSTNGELNADDPTAGHSNAPI 385

Query: 418 TAPTEVEVMDETKCCCFFKRRKRKTIQRHK 447
           TAP EVEV DETKCCCFFKRRKRK++QRHK
Sbjct: 386 TAPAEVEVADETKCCCFFKRRKRKSLQRHK 415


>gi|98986450 casein kinase 1, gamma 1 [Homo sapiens]
          Length = 422

 Score =  684 bits (1765), Expect = 0.0
 Identities = 345/451 (76%), Positives = 375/451 (83%), Gaps = 33/451 (7%)

Query: 1   MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSS-GVLMVGPNFRVGKKIGCGNFGELRL 59
           M++  ++KD+        + RS H +R +GSSSS GVLMVGPNFRVGKKIGCGNFGELRL
Sbjct: 1   MDHPSREKDERQRTTKPMAQRSAHCSRPSGSSSSSGVLMVGPNFRVGKKIGCGNFGELRL 60

Query: 60  GKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGS-GDGIPQVYYFGPCGKYNAMVLEL 118
           GKNLYTNEYVAIKLEP+KSRAPQLHLEYRFYKQLGS G+G+PQVYYFGPCGKYNAMVLEL
Sbjct: 61  GKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLEL 120

Query: 119 LGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQ 178
           LGPSLEDLFDLCDRTF+LKTVLMIAIQL+SRMEYVHSKNLIYRDVKPENFLIGR GNK +
Sbjct: 121 LGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKE 180

Query: 179 QVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHM 238
            VIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHM
Sbjct: 181 HVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHM 240

Query: 239 FMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFP-EMATYLRYVRRLDFFE 297
           FMYFLRGSLPWQGLKADTLKERYQKIGDTKR TPIE LCENFP EMATYLRYVRRLDFFE
Sbjct: 241 FMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFE 300

Query: 298 KPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSS-NREAHQHRDKM 356
           KPDY+YLR LFTDLF++KGY FDY YDW+G+ +PTPVG+V  D   S+  RE+H HRD+ 
Sbjct: 301 KPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTHRDRP 360

Query: 357 QQSKNQSADHRAAWDSQQANPHHLRAHLAADRHGGSVQVVSSTNGELNTDDPTAGRSNAP 416
            Q +                   LR            QVVSSTNGELN DDPT   SNAP
Sbjct: 361 SQQQ------------------PLRN-----------QVVSSTNGELNVDDPTGAHSNAP 391

Query: 417 ITAPTEVEVMDETKCCCFFKRRKRKTIQRHK 447
           ITA  EVEV++E KCCCFFKR+++KT QRHK
Sbjct: 392 ITAHAEVEVVEEAKCCCFFKRKRKKTAQRHK 422


>gi|23199991 casein kinase 1 epsilon [Homo sapiens]
          Length = 416

 Score =  367 bits (943), Expect = e-102
 Identities = 180/328 (54%), Positives = 242/328 (73%), Gaps = 7/328 (2%)

Query: 37  LMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSG 96
           L VG  +R+G+KIG G+FG++ LG N+ + E VAIKLE +K++ PQLH+E +FYK +  G
Sbjct: 3   LRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGG 62

Query: 97  DGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSK 156
            GIP + + G  G YN MV+ELLGPSLEDLF+ C R FSLKTVL++A Q+ISR+EY+HSK
Sbjct: 63  VGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSK 122

Query: 157 NLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYM 216
           N I+RDVKP+NFL+G    K   +++IIDFGLAK+Y D  T +HIPYRE+K+LTGTARY 
Sbjct: 123 NFIHRDVKPDNFLMGL--GKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA 180

Query: 217 SINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVL 276
           SINTHLG EQSRRDDLE+LG++ MYF  GSLPWQGLKA T +++Y++I + K +TPIEVL
Sbjct: 181 SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL 240

Query: 277 CENFP-EMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVG 335
           C+ +P E +TYL + R L F +KPDY YLR+LF +LF R+G+ +DY +DW   +     G
Sbjct: 241 CKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKF----G 296

Query: 336 AVQQDPALSSNREAHQHRDKMQQSKNQS 363
           A +    +   R  H+  ++M Q +  +
Sbjct: 297 AARNPEDVDRERREHEREERMGQLRGSA 324


>gi|4503093 casein kinase 1 epsilon [Homo sapiens]
          Length = 416

 Score =  367 bits (943), Expect = e-102
 Identities = 180/328 (54%), Positives = 242/328 (73%), Gaps = 7/328 (2%)

Query: 37  LMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSG 96
           L VG  +R+G+KIG G+FG++ LG N+ + E VAIKLE +K++ PQLH+E +FYK +  G
Sbjct: 3   LRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGG 62

Query: 97  DGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSK 156
            GIP + + G  G YN MV+ELLGPSLEDLF+ C R FSLKTVL++A Q+ISR+EY+HSK
Sbjct: 63  VGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSK 122

Query: 157 NLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYM 216
           N I+RDVKP+NFL+G    K   +++IIDFGLAK+Y D  T +HIPYRE+K+LTGTARY 
Sbjct: 123 NFIHRDVKPDNFLMGL--GKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA 180

Query: 217 SINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVL 276
           SINTHLG EQSRRDDLE+LG++ MYF  GSLPWQGLKA T +++Y++I + K +TPIEVL
Sbjct: 181 SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL 240

Query: 277 CENFP-EMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVG 335
           C+ +P E +TYL + R L F +KPDY YLR+LF +LF R+G+ +DY +DW   +     G
Sbjct: 241 CKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKF----G 296

Query: 336 AVQQDPALSSNREAHQHRDKMQQSKNQS 363
           A +    +   R  H+  ++M Q +  +
Sbjct: 297 AARNPEDVDRERREHEREERMGQLRGSA 324


>gi|20544145 casein kinase 1, delta isoform 2 [Homo sapiens]
          Length = 409

 Score =  360 bits (925), Expect = 1e-99
 Identities = 179/326 (54%), Positives = 238/326 (73%), Gaps = 9/326 (2%)

Query: 37  LMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSG 96
           L VG  +R+G+KIG G+FG++ LG ++   E VAIKLE +K++ PQLH+E + YK +  G
Sbjct: 3   LRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGG 62

Query: 97  DGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSK 156
            GIP + + G  G YN MV+ELLGPSLEDLF+ C R FSLKTVL++A Q+ISR+EY+HSK
Sbjct: 63  VGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSK 122

Query: 157 NLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYM 216
           N I+RDVKP+NFL+G    K   +++IIDFGLAK+Y D  T +HIPYRE+K+LTGTARY 
Sbjct: 123 NFIHRDVKPDNFLMGL--GKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA 180

Query: 217 SINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVL 276
           SINTHLG EQSRRDDLE+LG++ MYF  GSLPWQGLKA T +++Y++I + K +TPIEVL
Sbjct: 181 SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL 240

Query: 277 CENFP-EMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVG 335
           C+ +P E ATYL + R L F +KPDY YLR+LF +LF R+G+ +DY +DW    L     
Sbjct: 241 CKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDW--NMLKFGAS 298

Query: 336 AVQQDPALSSNREAHQHRDKMQQSKN 361
               D    + RE     ++++ S+N
Sbjct: 299 RAADD----AERERRDREERLRHSRN 320


>gi|20149530 casein kinase 1, delta isoform 1 [Homo sapiens]
          Length = 415

 Score =  360 bits (925), Expect = 1e-99
 Identities = 179/326 (54%), Positives = 238/326 (73%), Gaps = 9/326 (2%)

Query: 37  LMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSG 96
           L VG  +R+G+KIG G+FG++ LG ++   E VAIKLE +K++ PQLH+E + YK +  G
Sbjct: 3   LRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGG 62

Query: 97  DGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSK 156
            GIP + + G  G YN MV+ELLGPSLEDLF+ C R FSLKTVL++A Q+ISR+EY+HSK
Sbjct: 63  VGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSK 122

Query: 157 NLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYM 216
           N I+RDVKP+NFL+G    K   +++IIDFGLAK+Y D  T +HIPYRE+K+LTGTARY 
Sbjct: 123 NFIHRDVKPDNFLMGL--GKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA 180

Query: 217 SINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVL 276
           SINTHLG EQSRRDDLE+LG++ MYF  GSLPWQGLKA T +++Y++I + K +TPIEVL
Sbjct: 181 SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL 240

Query: 277 CENFP-EMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVG 335
           C+ +P E ATYL + R L F +KPDY YLR+LF +LF R+G+ +DY +DW    L     
Sbjct: 241 CKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDW--NMLKFGAS 298

Query: 336 AVQQDPALSSNREAHQHRDKMQQSKN 361
               D    + RE     ++++ S+N
Sbjct: 299 RAADD----AERERRDREERLRHSRN 320


>gi|68303572 casein kinase 1, alpha 1 isoform 2 [Homo sapiens]
          Length = 337

 Score =  332 bits (850), Expect = 5e-91
 Identities = 167/300 (55%), Positives = 217/300 (72%), Gaps = 7/300 (2%)

Query: 29  TGSSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYR 88
           + S S    +VG  +++ +KIG G+FG++ L  N+   E VA+KLE  K+R PQL  E +
Sbjct: 3   SSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESK 62

Query: 89  FYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLIS 148
            YK L  G GIP + ++G    YN +V++LLGPSLEDLF+ C R F++KTVLM+A Q+IS
Sbjct: 63  LYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMIS 122

Query: 149 RMEYVHSKNLIYRDVKPENFL--IGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREH 206
           R+EYVH+KN I+RD+KP+NFL  IGR  NK    + +IDFGLAK+Y D  T++HIPYRE 
Sbjct: 123 RIEYVHTKNFIHRDIKPDNFLMGIGRHCNK----LFLIDFGLAKKYRDNRTRQHIPYRED 178

Query: 207 KSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGD 266
           K+LTGTARY SIN HLG EQSRRDD+E+LG++ MYF R SLPWQGLKA T K++Y+KI +
Sbjct: 179 KNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISE 238

Query: 267 TKRATPIEVLCENFP-EMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDW 325
            K +TP+EVLC+ FP E A YL Y R L F E PDY YLR+LF  LF    + +DY +DW
Sbjct: 239 KKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDW 298


>gi|68303575 casein kinase 1, alpha 1 isoform 1 [Homo sapiens]
          Length = 365

 Score =  323 bits (827), Expect = 3e-88
 Identities = 167/324 (51%), Positives = 218/324 (67%), Gaps = 27/324 (8%)

Query: 29  TGSSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYR 88
           + S S    +VG  +++ +KIG G+FG++ L  N+   E VA+KLE  K+R PQL  E +
Sbjct: 3   SSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESK 62

Query: 89  FYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLIS 148
            YK L  G GIP + ++G    YN +V++LLGPSLEDLF+ C R F++KTVLM+A Q+IS
Sbjct: 63  LYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMIS 122

Query: 149 RMEYVHSKNLIYRDVKPENFL--IGRPGNKTQQ------------------------VIH 182
           R+EYVH+KN I+RD+KP+NFL  IGR  NK  +                         + 
Sbjct: 123 RIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLF 182

Query: 183 IIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYF 242
           +IDFGLAK+Y D  T++HIPYRE K+LTGTARY SIN HLG EQSRRDD+E+LG++ MYF
Sbjct: 183 LIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYF 242

Query: 243 LRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFP-EMATYLRYVRRLDFFEKPDY 301
            R SLPWQGLKA T K++Y+KI + K +TP+EVLC+ FP E A YL Y R L F E PDY
Sbjct: 243 NRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDY 302

Query: 302 DYLRKLFTDLFDRKGYMFDYEYDW 325
            YLR+LF  LF    + +DY +DW
Sbjct: 303 MYLRQLFRILFRTLNHQYDYTFDW 326


>gi|21624639 casein kinase 1, alpha 1-like [Homo sapiens]
          Length = 337

 Score =  321 bits (822), Expect = 1e-87
 Identities = 172/337 (51%), Positives = 228/337 (67%), Gaps = 13/337 (3%)

Query: 31  SSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFY 90
           S S   L+VG  +++ +KIG G+FG++ LG      E VA+KLE  K + PQL  E + Y
Sbjct: 5   SGSKAELVVGGKYKLVRKIGSGSFGDVYLGITTTNGEEVAVKLESQKVKHPQLLYESKLY 64

Query: 91  KQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRM 150
             L  G GIP ++++G     N +V++LLGPSLEDLF+ C R F++KTVLM+A Q+ISR+
Sbjct: 65  TILQGGVGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRI 124

Query: 151 EYVHSKNLIYRDVKPENFLI--GRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKS 208
           EYVH+KN ++RD+KP+NFL+  GR  NK    + +IDFGLAK+Y D  T++HIPYRE K 
Sbjct: 125 EYVHTKNFLHRDIKPDNFLMGTGRHCNK----LFLIDFGLAKKYRDNRTRQHIPYREDKH 180

Query: 209 LTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTK 268
           L GT RY SIN HLG EQSRRDD+E+LG++FMYF R SLPWQGLKA T K++Y+KI + K
Sbjct: 181 LIGTVRYASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLKAMTKKQKYEKISEKK 240

Query: 269 RATPIEVLCENFP-EMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDW-I 326
            +TP+EVLC+ FP E A YL Y R L F E PDY YLR+LF  LF    + +DY +DW +
Sbjct: 241 MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTLNHQYDYTFDWTM 300

Query: 327 GKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSKNQS 363
            KQ      A QQ  + S   +  Q +   Q  KN++
Sbjct: 301 LKQ-----KAAQQAASSSGQGQQAQTQTGKQTEKNKN 332


>gi|58761548 tau tubulin kinase 1 [Homo sapiens]
          Length = 1321

 Score =  154 bits (390), Expect = 1e-37
 Identities = 96/290 (33%), Positives = 154/290 (53%), Gaps = 10/290 (3%)

Query: 38  MVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGD 97
           +V   ++V KKIG G FGE+    +L T E VA+K+E  +     L +E    K+L   D
Sbjct: 29  VVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKD 88

Query: 98  GIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDR-TFSLKTVLMIAIQLISRMEYVHSK 156
            + +    G   K+N +V++L G +L DL     R TF+L T L +  Q++  +E +HS 
Sbjct: 89  HVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSV 148

Query: 157 NLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYM 216
             ++RD+KP NF +GR  + T +  +++DFGLA++Y +  T    P R      GT RY 
Sbjct: 149 GFLHRDIKPSNFAMGRLPS-TYRKCYMLDFGLARQYTN-TTGDVRPPRNVAGFRGTVRYA 206

Query: 217 SINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVL 276
           S+N H  +E  R DDL +L +M + F  G LPW+ +K        +++G  K      +L
Sbjct: 207 SVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDK------EQVGMIKEKYEHRML 260

Query: 277 CENFP-EMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDW 325
            ++ P E   +L ++  LD+F KPDY  +  +F +    +G   +  +DW
Sbjct: 261 LKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDW 310


>gi|116812624 tau tubulin kinase 2 [Homo sapiens]
          Length = 1244

 Score =  148 bits (373), Expect = 1e-35
 Identities = 91/291 (31%), Positives = 155/291 (53%), Gaps = 10/291 (3%)

Query: 37  LMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSG 96
           ++V   ++V +KIG G FGE+    ++ T E VA+K+E  +     L +E    K+L   
Sbjct: 15  ILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGK 74

Query: 97  DGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDR-TFSLKTVLMIAIQLISRMEYVHS 155
           D + +    G   ++N +V++L G +L DL     R TF++ T L +  Q++  +E +HS
Sbjct: 75  DHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHS 134

Query: 156 KNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY 215
              ++RD+KP NF +GR  + T +  +++DFGLA+++ +       P R      GT RY
Sbjct: 135 VGFLHRDIKPSNFAMGRFPS-TCRKCYMLDFGLARQFTNSCGDVRPP-RAVAGFRGTVRY 192

Query: 216 MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEV 275
            SIN H  +E  R DDL +L +M + F+ G LPW+ +K        +++G  K      +
Sbjct: 193 ASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDK------EQVGSIKERYDHRL 246

Query: 276 LCENF-PEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDW 325
           + ++  PE + +L ++  LD+F KPDY  L  +F +     G +    +DW
Sbjct: 247 MLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDW 297


>gi|4507903 vaccinia related kinase 1 [Homo sapiens]
          Length = 396

 Score =  117 bits (292), Expect = 3e-26
 Identities = 82/297 (27%), Positives = 141/297 (47%), Gaps = 32/297 (10%)

Query: 38  MVGPNFRVGKKIGCGNFG-----ELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQ 92
           M    ++VG  IG G FG     ++   +++ ++    +K+EP  S    L  E +FY++
Sbjct: 32  MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEP--SDNGPLFTELKFYQR 89

Query: 93  LGSGD--------------GIPQVYYFGPCGK----YNAMVLELLGPSLEDLFDLCDRTF 134
               +              G+P+ +  G   K    Y  M+++  G  L+ +++   + F
Sbjct: 90  AAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRF 149

Query: 135 SLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYID 194
           S KTVL ++++++  +EY+H    ++ D+K  N L+     K    ++++D+GLA  Y  
Sbjct: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY---KNPDQVYLVDYGLAYRYCP 206

Query: 195 PETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKA 254
               K       +   GT  + SI+ H G   SRR DLE LG+  + +L G LPW+    
Sbjct: 207 EGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLK 266

Query: 255 DTLKERYQKIGDTKRATPIEVLC---ENFP-EMATYLRYVRRLDFFEKPDYDYLRKL 307
           D    R  KI   +    +   C   +N P E+A Y+  V+ LD+ EKP Y+ LR +
Sbjct: 267 DPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDI 323


>gi|194440713 vaccinia related kinase 2 isoform 3 [Homo sapiens]
          Length = 396

 Score =  108 bits (269), Expect = 1e-23
 Identities = 101/369 (27%), Positives = 154/369 (41%), Gaps = 44/369 (11%)

Query: 38  MVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVA---IKLEPMKSRAPQLHLEYRFYKQLG 94
           M G  + +GKKIG G FG + L       E  A   +K+E  ++    L  E +FY+++ 
Sbjct: 24  MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGP--LFSELKFYQRVA 81

Query: 95  SGD--------------GIPQVYYFGPCG----KYNAMVLELLGPSLEDLFDLCDRTFSL 136
             D              GIP  Y  G        Y  MV+E LG  L+ +    + TF  
Sbjct: 82  KKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKK 140

Query: 137 KTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPE 196
            TVL + I+++  +EY+H    ++ D+K  N L+G    K    +++ D+GL+  Y    
Sbjct: 141 STVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY---KNPDQVYLADYGLSYRYCPNG 197

Query: 197 TKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW------- 249
             K       K   GT  + S++ H G   SRR D+E LG+  + +L G LPW       
Sbjct: 198 NHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDP 257

Query: 250 ---QGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRK 306
              Q  K + L E  Q +   K A      C    E+A +L     L + EKP+Y  L+K
Sbjct: 258 VAVQTAKTNLLDELPQSV--LKWAPSGSSCC----EIAQFLVCAHSLAYDEKPNYQALKK 311

Query: 307 LFTDLFDRKGYM-FDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSKNQSAD 365
           +        G + F  +   I    P       Q  A     +AH    + +    +SA+
Sbjct: 312 ILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAE 371

Query: 366 HRAAWDSQQ 374
             A W  Q+
Sbjct: 372 SCATWKVQK 380


>gi|194440711 vaccinia related kinase 2 isoform 2 [Homo sapiens]
          Length = 485

 Score =  108 bits (269), Expect = 1e-23
 Identities = 101/369 (27%), Positives = 154/369 (41%), Gaps = 44/369 (11%)

Query: 38  MVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVA---IKLEPMKSRAPQLHLEYRFYKQLG 94
           M G  + +GKKIG G FG + L       E  A   +K+E  ++    L  E +FY+++ 
Sbjct: 1   MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGP--LFSELKFYQRVA 58

Query: 95  SGD--------------GIPQVYYFGPCG----KYNAMVLELLGPSLEDLFDLCDRTFSL 136
             D              GIP  Y  G        Y  MV+E LG  L+ +    + TF  
Sbjct: 59  KKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKK 117

Query: 137 KTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPE 196
            TVL + I+++  +EY+H    ++ D+K  N L+G    K    +++ D+GL+  Y    
Sbjct: 118 STVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY---KNPDQVYLADYGLSYRYCPNG 174

Query: 197 TKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW------- 249
             K       K   GT  + S++ H G   SRR D+E LG+  + +L G LPW       
Sbjct: 175 NHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDP 234

Query: 250 ---QGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRK 306
              Q  K + L E  Q +   K A      C    E+A +L     L + EKP+Y  L+K
Sbjct: 235 VAVQTAKTNLLDELPQSV--LKWAPSGSSCC----EIAQFLVCAHSLAYDEKPNYQALKK 288

Query: 307 LFTDLFDRKGYM-FDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSKNQSAD 365
           +        G + F  +   I    P       Q  A     +AH    + +    +SA+
Sbjct: 289 ILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAE 348

Query: 366 HRAAWDSQQ 374
             A W  Q+
Sbjct: 349 SCATWKVQK 357


>gi|194440709 vaccinia related kinase 2 isoform 1 [Homo sapiens]
          Length = 508

 Score =  108 bits (269), Expect = 1e-23
 Identities = 101/369 (27%), Positives = 154/369 (41%), Gaps = 44/369 (11%)

Query: 38  MVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVA---IKLEPMKSRAPQLHLEYRFYKQLG 94
           M G  + +GKKIG G FG + L       E  A   +K+E  ++    L  E +FY+++ 
Sbjct: 24  MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGP--LFSELKFYQRVA 81

Query: 95  SGD--------------GIPQVYYFGPCG----KYNAMVLELLGPSLEDLFDLCDRTFSL 136
             D              GIP  Y  G        Y  MV+E LG  L+ +    + TF  
Sbjct: 82  KKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKK 140

Query: 137 KTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPE 196
            TVL + I+++  +EY+H    ++ D+K  N L+G    K    +++ D+GL+  Y    
Sbjct: 141 STVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY---KNPDQVYLADYGLSYRYCPNG 197

Query: 197 TKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW------- 249
             K       K   GT  + S++ H G   SRR D+E LG+  + +L G LPW       
Sbjct: 198 NHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDP 257

Query: 250 ---QGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRK 306
              Q  K + L E  Q +   K A      C    E+A +L     L + EKP+Y  L+K
Sbjct: 258 VAVQTAKTNLLDELPQSV--LKWAPSGSSCC----EIAQFLVCAHSLAYDEKPNYQALKK 311

Query: 307 LFTDLFDRKGYM-FDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSKNQSAD 365
           +        G + F  +   I    P       Q  A     +AH    + +    +SA+
Sbjct: 312 ILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAE 371

Query: 366 HRAAWDSQQ 374
             A W  Q+
Sbjct: 372 SCATWKVQK 380


>gi|194440707 vaccinia related kinase 2 isoform 1 [Homo sapiens]
          Length = 508

 Score =  108 bits (269), Expect = 1e-23
 Identities = 101/369 (27%), Positives = 154/369 (41%), Gaps = 44/369 (11%)

Query: 38  MVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVA---IKLEPMKSRAPQLHLEYRFYKQLG 94
           M G  + +GKKIG G FG + L       E  A   +K+E  ++    L  E +FY+++ 
Sbjct: 24  MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGP--LFSELKFYQRVA 81

Query: 95  SGD--------------GIPQVYYFGPCG----KYNAMVLELLGPSLEDLFDLCDRTFSL 136
             D              GIP  Y  G        Y  MV+E LG  L+ +    + TF  
Sbjct: 82  KKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKK 140

Query: 137 KTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPE 196
            TVL + I+++  +EY+H    ++ D+K  N L+G    K    +++ D+GL+  Y    
Sbjct: 141 STVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY---KNPDQVYLADYGLSYRYCPNG 197

Query: 197 TKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW------- 249
             K       K   GT  + S++ H G   SRR D+E LG+  + +L G LPW       
Sbjct: 198 NHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDP 257

Query: 250 ---QGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRK 306
              Q  K + L E  Q +   K A      C    E+A +L     L + EKP+Y  L+K
Sbjct: 258 VAVQTAKTNLLDELPQSV--LKWAPSGSSCC----EIAQFLVCAHSLAYDEKPNYQALKK 311

Query: 307 LFTDLFDRKGYM-FDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSKNQSAD 365
           +        G + F  +   I    P       Q  A     +AH    + +    +SA+
Sbjct: 312 ILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAE 371

Query: 366 HRAAWDSQQ 374
             A W  Q+
Sbjct: 372 SCATWKVQK 380


>gi|71164884 vaccinia related kinase 2 isoform 1 [Homo sapiens]
          Length = 508

 Score =  108 bits (269), Expect = 1e-23
 Identities = 101/369 (27%), Positives = 154/369 (41%), Gaps = 44/369 (11%)

Query: 38  MVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVA---IKLEPMKSRAPQLHLEYRFYKQLG 94
           M G  + +GKKIG G FG + L       E  A   +K+E  ++    L  E +FY+++ 
Sbjct: 24  MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGP--LFSELKFYQRVA 81

Query: 95  SGD--------------GIPQVYYFGPCG----KYNAMVLELLGPSLEDLFDLCDRTFSL 136
             D              GIP  Y  G        Y  MV+E LG  L+ +    + TF  
Sbjct: 82  KKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKK 140

Query: 137 KTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPE 196
            TVL + I+++  +EY+H    ++ D+K  N L+G    K    +++ D+GL+  Y    
Sbjct: 141 STVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY---KNPDQVYLADYGLSYRYCPNG 197

Query: 197 TKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW------- 249
             K       K   GT  + S++ H G   SRR D+E LG+  + +L G LPW       
Sbjct: 198 NHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDP 257

Query: 250 ---QGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRK 306
              Q  K + L E  Q +   K A      C    E+A +L     L + EKP+Y  L+K
Sbjct: 258 VAVQTAKTNLLDELPQSV--LKWAPSGSSCC----EIAQFLVCAHSLAYDEKPNYQALKK 311

Query: 307 LFTDLFDRKGYM-FDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSKNQSAD 365
           +        G + F  +   I    P       Q  A     +AH    + +    +SA+
Sbjct: 312 ILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAE 371

Query: 366 HRAAWDSQQ 374
             A W  Q+
Sbjct: 372 SCATWKVQK 380


>gi|209862855 vaccinia related kinase 2 isoform 6 [Homo sapiens]
          Length = 390

 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 75/272 (27%), Positives = 117/272 (43%), Gaps = 21/272 (7%)

Query: 114 MVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRP 173
           MV+E LG  L+ +    + TF   TVL + I+++  +EY+H    ++ D+K  N L+G  
Sbjct: 1   MVMERLGIDLQKISGQ-NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY- 58

Query: 174 GNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLE 233
             K    +++ D+GL+  Y      K       K   GT  + S++ H G   SRR D+E
Sbjct: 59  --KNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVE 116

Query: 234 ALGHMFMYFLRGSLPW----------QGLKADTLKERYQKIGDTKRATPIEVLCENFPEM 283
            LG+  + +L G LPW          Q  K + L E  Q +   K A      C    E+
Sbjct: 117 ILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSV--LKWAPSGSSCC----EI 170

Query: 284 ATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYM-FDYEYDWIGKQLPTPVGAVQQDPA 342
           A +L     L + EKP+Y  L+K+        G + F  +   I    P       Q  A
Sbjct: 171 AQFLVCAHSLAYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAA 230

Query: 343 LSSNREAHQHRDKMQQSKNQSADHRAAWDSQQ 374
                +AH    + +    +SA+  A W  Q+
Sbjct: 231 TKQVNKAHNRLIEKKVHSERSAESCATWKVQK 262


>gi|71164888 vaccinia related kinase 3 isoform 2 [Homo sapiens]
          Length = 424

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 59/203 (29%), Positives = 99/203 (48%), Gaps = 12/203 (5%)

Query: 110 KYNAMVLELLGPSLEDLFDLCDR-TFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENF 168
           KY  +VL  LG SL+   D+  +   S ++VL +A +L+  +E++H    ++ +V  EN 
Sbjct: 203 KYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENI 262

Query: 169 LIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYRE--HKSLTGTARYMSINTHLGKEQ 226
            +  P +++Q  + +  +G A  Y    + KH+ Y E       G   ++S++ H G   
Sbjct: 263 FVD-PEDQSQ--VTLAGYGFAFRYCP--SGKHVAYVEGSRSPHEGDLEFISMDLHKGCGP 317

Query: 227 SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENF----PE 282
           SRR DL++LG+  + +L G LPW     +T     QK     +  P    C ++      
Sbjct: 318 SRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSET 377

Query: 283 MATYLRYVRRLDFFEKPDYDYLR 305
           +  YL+ V  L + EKP Y  LR
Sbjct: 378 LQKYLKVVMALTYEEKPPYAMLR 400


>gi|71164886 vaccinia related kinase 3 isoform 1 [Homo sapiens]
          Length = 474

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 59/203 (29%), Positives = 99/203 (48%), Gaps = 12/203 (5%)

Query: 110 KYNAMVLELLGPSLEDLFDLCDR-TFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENF 168
           KY  +VL  LG SL+   D+  +   S ++VL +A +L+  +E++H    ++ +V  EN 
Sbjct: 253 KYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENI 312

Query: 169 LIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYRE--HKSLTGTARYMSINTHLGKEQ 226
            +  P +++Q  + +  +G A  Y    + KH+ Y E       G   ++S++ H G   
Sbjct: 313 FVD-PEDQSQ--VTLAGYGFAFRYCP--SGKHVAYVEGSRSPHEGDLEFISMDLHKGCGP 367

Query: 227 SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENF----PE 282
           SRR DL++LG+  + +L G LPW     +T     QK     +  P    C ++      
Sbjct: 368 SRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSET 427

Query: 283 MATYLRYVRRLDFFEKPDYDYLR 305
           +  YL+ V  L + EKP Y  LR
Sbjct: 428 LQKYLKVVMALTYEEKPPYAMLR 450


>gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform 1
           [Homo sapiens]
          Length = 556

 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 60/222 (27%), Positives = 100/222 (45%), Gaps = 32/222 (14%)

Query: 42  NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMK-------------SRAPQLHLEYR 88
           +F+ GK +G G+F  + L + L T+   AIK+   +              R     L++ 
Sbjct: 81  DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHP 140

Query: 89  FYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLIS 148
           F+ +L       +  YFG     N  +L+ +   +    + C R ++         +++S
Sbjct: 141 FFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR-KIGSFDETCTRFYTA--------EIVS 191

Query: 149 RMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKS 208
            +EY+H K +I+RD+KPEN L+          I I DFG AK  + PE+K+        S
Sbjct: 192 ALEYLHGKGIIHRDLKPENILLNE-----DMHIQITDFGTAK-VLSPESKQ----ARANS 241

Query: 209 LTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQ 250
             GTA+Y+S      K   +  DL ALG +    + G  P++
Sbjct: 242 FVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFR 283


>gi|239756427 PREDICTED: similar to 3-phosphoinositide dependent
           protein kinase-1 [Homo sapiens]
          Length = 471

 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 60/222 (27%), Positives = 100/222 (45%), Gaps = 32/222 (14%)

Query: 42  NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMK-------------SRAPQLHLEYR 88
           +F+ GK +G G+F  + L + L T+   AIK+   +              R     L++ 
Sbjct: 100 DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHP 159

Query: 89  FYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLIS 148
           F+ +L       +  YFG     N  +L+ +   +    + C R ++         +++S
Sbjct: 160 FFVKLYFTFQTTRRLYFGLSYAKNGELLKYIR-KIGSFDETCTRFYTA--------EIVS 210

Query: 149 RMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKS 208
            +EY+H K +I+RD+KPEN L+          I I DFG AK  + PE+K+        S
Sbjct: 211 ALEYLHGKGIIHRDLKPENILLNE-----DMHIQITDFGTAK-VLSPESKQ----ARANS 260

Query: 209 LTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQ 250
             GTA+Y+S      K   +  DL ALG +    + G  P++
Sbjct: 261 FVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFR 302


>gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo
           sapiens]
          Length = 396

 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 60/222 (27%), Positives = 100/222 (45%), Gaps = 32/222 (14%)

Query: 42  NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMK-------------SRAPQLHLEYR 88
           +F+ GK +G G+F  + L + L T+   AIK+   +              R     L++ 
Sbjct: 54  DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHP 113

Query: 89  FYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLIS 148
           F+ +L       +  YFG     N  +L+ +   +    + C R ++         +++S
Sbjct: 114 FFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR-KIGSFDETCTRFYTA--------EIVS 164

Query: 149 RMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKS 208
            +EY+H K +I+RD+KPEN L+          I I DFG AK  + PE+K+        S
Sbjct: 165 ALEYLHGKGIIHRDLKPENILLNE-----DMHIQITDFGTAK-VLSPESKQ----ARANS 214

Query: 209 LTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQ 250
             GTA+Y+S      K   +  DL ALG +    + G  P++
Sbjct: 215 FVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFR 256


>gi|38327572 serine/threonine protein kinase 6 [Homo sapiens]
          Length = 403

 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 59/238 (24%), Positives = 106/238 (44%), Gaps = 27/238 (11%)

Query: 42  NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI-- 99
           +F +G+ +G G FG + L +   +   +A+K+   K++  +  +E++  +++     +  
Sbjct: 132 DFEIGRPLGKGKFGNVYLAREKQSKFILALKVL-FKAQLEKAGVEHQLRREVEIQSHLRH 190

Query: 100 PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVH 154
           P +     Y+      Y  +    LG    +L  L    F  +       +L + + Y H
Sbjct: 191 PNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCH 248

Query: 155 SKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTAR 214
           SK +I+RD+KPEN L+G  G      + I DFG +          H P     +L GT  
Sbjct: 249 SKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRTTLCGTLD 294

Query: 215 YMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP 272
           Y+      G+    + DL +LG +   FL G  P++   A+T +E Y++I   +   P
Sbjct: 295 YLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP 349


>gi|38327570 serine/threonine protein kinase 6 [Homo sapiens]
          Length = 403

 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 59/238 (24%), Positives = 106/238 (44%), Gaps = 27/238 (11%)

Query: 42  NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI-- 99
           +F +G+ +G G FG + L +   +   +A+K+   K++  +  +E++  +++     +  
Sbjct: 132 DFEIGRPLGKGKFGNVYLAREKQSKFILALKVL-FKAQLEKAGVEHQLRREVEIQSHLRH 190

Query: 100 PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVH 154
           P +     Y+      Y  +    LG    +L  L    F  +       +L + + Y H
Sbjct: 191 PNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCH 248

Query: 155 SKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTAR 214
           SK +I+RD+KPEN L+G  G      + I DFG +          H P     +L GT  
Sbjct: 249 SKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRTTLCGTLD 294

Query: 215 YMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP 272
           Y+      G+    + DL +LG +   FL G  P++   A+T +E Y++I   +   P
Sbjct: 295 YLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP 349


>gi|38327568 serine/threonine protein kinase 6 [Homo sapiens]
          Length = 403

 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 59/238 (24%), Positives = 106/238 (44%), Gaps = 27/238 (11%)

Query: 42  NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI-- 99
           +F +G+ +G G FG + L +   +   +A+K+   K++  +  +E++  +++     +  
Sbjct: 132 DFEIGRPLGKGKFGNVYLAREKQSKFILALKVL-FKAQLEKAGVEHQLRREVEIQSHLRH 190

Query: 100 PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVH 154
           P +     Y+      Y  +    LG    +L  L    F  +       +L + + Y H
Sbjct: 191 PNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCH 248

Query: 155 SKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTAR 214
           SK +I+RD+KPEN L+G  G      + I DFG +          H P     +L GT  
Sbjct: 249 SKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRTTLCGTLD 294

Query: 215 YMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP 272
           Y+      G+    + DL +LG +   FL G  P++   A+T +E Y++I   +   P
Sbjct: 295 YLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP 349


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,689,313
Number of Sequences: 37866
Number of extensions: 808835
Number of successful extensions: 3151
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 457
Number of HSP's successfully gapped in prelim test: 254
Number of HSP's that attempted gapping in prelim test: 2213
Number of HSP's gapped (non-prelim): 851
length of query: 447
length of database: 18,247,518
effective HSP length: 105
effective length of query: 342
effective length of database: 14,271,588
effective search space: 4880883096
effective search space used: 4880883096
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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