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Search of human proteins with 6912638
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
(277 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 551 e-157
gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens] 451 e-127
gi|197333706 leucine rich repeat containing 8 family, member D [... 110 2e-24
gi|34222199 leucine rich repeat containing 8 family, member D [H... 110 2e-24
gi|62241040 leucine rich repeat containing 8 family, member A [H... 109 3e-24
gi|187829877 leucine rich repeat containing 8 family, member A [... 109 3e-24
gi|187829871 leucine rich repeat containing 8 family, member A [... 109 3e-24
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 109 3e-24
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 108 5e-24
gi|45827729 scribble isoform b [Homo sapiens] 107 9e-24
gi|45827731 scribble isoform a [Homo sapiens] 107 9e-24
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 107 1e-23
gi|154091020 leucine-rich repeats and calponin homology (CH) dom... 106 2e-23
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 105 6e-23
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 105 6e-23
gi|33859670 leucine-rich repeats and calponin homology (CH) doma... 103 1e-22
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 102 4e-22
gi|14249428 leucine-rich repeats and calponin homology (CH) doma... 102 5e-22
gi|197333692 leucine rich repeat containing 8 family, member B [... 100 1e-21
gi|21245134 leucine rich repeat containing 8 family, member B [H... 100 1e-21
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 100 1e-21
gi|157743290 leucine rich repeat containing 30 [Homo sapiens] 98 7e-21
gi|238908508 leucine-rich repeat and death domain-containing pro... 98 9e-21
gi|30181233 leucine-rich repeats and calponin homology (CH) doma... 98 9e-21
gi|4503743 flightless I homolog [Homo sapiens] 97 2e-20
gi|40217803 leucine rich repeat containing 8 family, member E [H... 96 3e-20
gi|61742786 leucine rich repeat and death domain containing prot... 96 3e-20
gi|61742784 leucine rich repeat and death domain containing prot... 96 3e-20
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 96 3e-20
gi|19923729 leucine rich repeat containing 8 family, member C [H... 95 6e-20
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 551 bits (1421), Expect = e-157
Identities = 277/277 (100%), Positives = 277/277 (100%)
Query: 1 MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIA 60
MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIA
Sbjct: 1 MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIA 60
Query: 61 ELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNN 120
ELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNN
Sbjct: 61 ELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNN 120
Query: 121 LSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT 180
LSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT
Sbjct: 121 LSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT 180
Query: 181 QLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHVFEYIRSE 240
QLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHVFEYIRSE
Sbjct: 181 QLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHVFEYIRSE 240
Query: 241 TYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAAKNR 277
TYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAAKNR
Sbjct: 241 TYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAAKNR 277
>gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens]
Length = 224
Score = 451 bits (1159), Expect = e-127
Identities = 224/224 (100%), Positives = 224/224 (100%)
Query: 54 MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 113
MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV
Sbjct: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 60
Query: 114 LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP 173
LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP
Sbjct: 61 LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP 120
Query: 174 KEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHV 233
KEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHV
Sbjct: 121 KEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHV 180
Query: 234 FEYIRSETYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAAKNR 277
FEYIRSETYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAAKNR
Sbjct: 181 FEYIRSETYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAAKNR 224
Score = 54.7 bits (130), Expect = 9e-08
Identities = 29/89 (32%), Positives = 49/89 (55%)
Query: 20 VDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELP 79
+D++ +S F L+ + L LS N ++PP+I +L L++L+ +N + LP
Sbjct: 61 LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP 120
Query: 80 TQISSLQKLKHLNLGMNRLNTLPRGFGSL 108
+I L +LK L++ NRL LP G+L
Sbjct: 121 KEIGELTQLKELHIQGNRLTVLPPELGNL 149
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 110 bits (274), Expect = 2e-24
Identities = 65/185 (35%), Positives = 101/185 (54%), Gaps = 25/185 (13%)
Query: 16 NQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQI 75
N E+D+ I + ++ L +T L L HNK+ +PP+I +KNLE L F NN++
Sbjct: 659 NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKL 718
Query: 76 EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 135
E LP + SLQKL+ LD++YNN+S +P L
Sbjct: 719 ESLPVAVFSLQKLR-----------------------CLDVSYNNIS--MIPIEIGLLQN 753
Query: 136 LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVL 195
L+ L+++ N +ILP + K KL+ L+L N + SLP+++G+L+QL +L ++GN L L
Sbjct: 754 LQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRL 813
Query: 196 PPELG 200
P +LG
Sbjct: 814 PAQLG 818
Score = 81.3 bits (199), Expect = 9e-16
Identities = 58/185 (31%), Positives = 98/185 (52%), Gaps = 4/185 (2%)
Query: 28 SNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQIS--SL 85
+ +L +N L + ++ +L L + +L +P I L NL+ L+ +N I + IS L
Sbjct: 623 TKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHL 682
Query: 86 QKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDND 145
++L L L N++ T+P + LE L + N L SLP F L LR L +S N+
Sbjct: 683 KRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLE--SLPVAVFSLQKLRCLDVSYNN 740
Query: 146 FEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLT 205
++P +IG L LQ L + N + LPK++ + +L+ L++ N +T LP ++G L
Sbjct: 741 ISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQL 800
Query: 206 GQKQV 210
Q ++
Sbjct: 801 TQLEL 805
Score = 70.5 bits (171), Expect = 2e-12
Identities = 59/199 (29%), Positives = 95/199 (47%), Gaps = 30/199 (15%)
Query: 28 SNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELK-NLEVLNFFNNQIEELPTQISSLQ 86
+ M+ + L L H+ L + N LT VP NI ++ +L L N+ + L ++SL+
Sbjct: 576 NKMIGLESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLV--LNSLK 632
Query: 87 KLKH---LNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSE-------------------- 123
K+ + L L L +P SL L+ LDL NN+
Sbjct: 633 KMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWH 692
Query: 124 ---NSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT 180
++P + ++ L +LY S+N E LP + L KL+ L + N++ +P EIG L
Sbjct: 693 NKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQ 752
Query: 181 QLKELHIQGNRLTVLPPEL 199
L+ LHI GN++ +LP +L
Sbjct: 753 NLQHLHITGNKVDILPKQL 771
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 110 bits (274), Expect = 2e-24
Identities = 65/185 (35%), Positives = 101/185 (54%), Gaps = 25/185 (13%)
Query: 16 NQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQI 75
N E+D+ I + ++ L +T L L HNK+ +PP+I +KNLE L F NN++
Sbjct: 659 NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKL 718
Query: 76 EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 135
E LP + SLQKL+ LD++YNN+S +P L
Sbjct: 719 ESLPVAVFSLQKLR-----------------------CLDVSYNNIS--MIPIEIGLLQN 753
Query: 136 LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVL 195
L+ L+++ N +ILP + K KL+ L+L N + SLP+++G+L+QL +L ++GN L L
Sbjct: 754 LQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRL 813
Query: 196 PPELG 200
P +LG
Sbjct: 814 PAQLG 818
Score = 81.3 bits (199), Expect = 9e-16
Identities = 58/185 (31%), Positives = 98/185 (52%), Gaps = 4/185 (2%)
Query: 28 SNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQIS--SL 85
+ +L +N L + ++ +L L + +L +P I L NL+ L+ +N I + IS L
Sbjct: 623 TKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHL 682
Query: 86 QKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDND 145
++L L L N++ T+P + LE L + N L SLP F L LR L +S N+
Sbjct: 683 KRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLE--SLPVAVFSLQKLRCLDVSYNN 740
Query: 146 FEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLT 205
++P +IG L LQ L + N + LPK++ + +L+ L++ N +T LP ++G L
Sbjct: 741 ISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQL 800
Query: 206 GQKQV 210
Q ++
Sbjct: 801 TQLEL 805
Score = 70.5 bits (171), Expect = 2e-12
Identities = 59/199 (29%), Positives = 95/199 (47%), Gaps = 30/199 (15%)
Query: 28 SNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELK-NLEVLNFFNNQIEELPTQISSLQ 86
+ M+ + L L H+ L + N LT VP NI ++ +L L N+ + L ++SL+
Sbjct: 576 NKMIGLESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLV--LNSLK 632
Query: 87 KLKH---LNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSE-------------------- 123
K+ + L L L +P SL L+ LDL NN+
Sbjct: 633 KMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWH 692
Query: 124 ---NSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT 180
++P + ++ L +LY S+N E LP + L KL+ L + N++ +P EIG L
Sbjct: 693 NKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQ 752
Query: 181 QLKELHIQGNRLTVLPPEL 199
L+ LHI GN++ +LP +L
Sbjct: 753 NLQHLHITGNKVDILPKQL 771
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 109 bits (272), Expect = 3e-24
Identities = 67/186 (36%), Positives = 100/186 (53%), Gaps = 4/186 (2%)
Query: 16 NQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQI 75
N E+D+ D + + ++ L +T L L +N + +P I L NLE L N+I
Sbjct: 615 NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674
Query: 76 EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 135
E++PTQ+ +KL++L+L N L LP G L L+ L +T N + +LP F
Sbjct: 675 EKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRI--ETLPPELFQCRK 732
Query: 136 LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKE--LHIQGNRLT 193
LRAL+L +N + LP +G+LT L + LR N L LP E+GE LK L ++ +
Sbjct: 733 LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFN 792
Query: 194 VLPPEL 199
LPPE+
Sbjct: 793 TLPPEV 798
Score = 59.7 bits (143), Expect = 3e-09
Identities = 54/187 (28%), Positives = 81/187 (43%), Gaps = 26/187 (13%)
Query: 41 HITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISS----LQKLKHLNLGMN 96
H+T + + N +V + ELK L+VL +N + +LP ++ LQKL N G
Sbjct: 522 HLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTK 580
Query: 97 R---------------------LNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 135
L +P SL L+ +DL NNL +F +L
Sbjct: 581 LIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHR 640
Query: 136 LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVL 195
L L L N +P IG LT L+ L L N + +P ++ +L+ L + N LT L
Sbjct: 641 LTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFL 700
Query: 196 PPELGNL 202
P ++G L
Sbjct: 701 PADIGLL 707
Score = 40.0 bits (92), Expect = 0.002
Identities = 51/191 (26%), Positives = 82/191 (42%), Gaps = 9/191 (4%)
Query: 1 MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIA 60
+ +SLKK ES + D+ D + N + F L I Q ++K V +
Sbjct: 344 LRRSLKKYSFESIREESSYSDIPD--VKN----DFAFMLHLIDQYDPLYSKRFAVFLSEV 397
Query: 61 ELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNN 120
L LN N + Q + L L + L+ +P L LEVL L
Sbjct: 398 SENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLEL-- 455
Query: 121 LSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK-LQILSLRDNDLISLPKEIGEL 179
+ + ++P + LT L+ L+L +I P + L + L+ L ++ D+ +P I L
Sbjct: 456 IPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSL 515
Query: 180 TQLKELHIQGN 190
L+ELH+ GN
Sbjct: 516 KTLEELHLTGN 526
Score = 28.9 bits (63), Expect = 5.2
Identities = 16/54 (29%), Positives = 27/54 (50%)
Query: 149 LPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 202
+P + L +L++L L +++P I +LT LKEL + + P L L
Sbjct: 438 IPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFL 491
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 109 bits (272), Expect = 3e-24
Identities = 67/186 (36%), Positives = 100/186 (53%), Gaps = 4/186 (2%)
Query: 16 NQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQI 75
N E+D+ D + + ++ L +T L L +N + +P I L NLE L N+I
Sbjct: 615 NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674
Query: 76 EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 135
E++PTQ+ +KL++L+L N L LP G L L+ L +T N + +LP F
Sbjct: 675 EKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRI--ETLPPELFQCRK 732
Query: 136 LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKE--LHIQGNRLT 193
LRAL+L +N + LP +G+LT L + LR N L LP E+GE LK L ++ +
Sbjct: 733 LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFN 792
Query: 194 VLPPEL 199
LPPE+
Sbjct: 793 TLPPEV 798
Score = 59.7 bits (143), Expect = 3e-09
Identities = 54/187 (28%), Positives = 81/187 (43%), Gaps = 26/187 (13%)
Query: 41 HITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISS----LQKLKHLNLGMN 96
H+T + + N +V + ELK L+VL +N + +LP ++ LQKL N G
Sbjct: 522 HLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTK 580
Query: 97 R---------------------LNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 135
L +P SL L+ +DL NNL +F +L
Sbjct: 581 LIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHR 640
Query: 136 LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVL 195
L L L N +P IG LT L+ L L N + +P ++ +L+ L + N LT L
Sbjct: 641 LTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFL 700
Query: 196 PPELGNL 202
P ++G L
Sbjct: 701 PADIGLL 707
Score = 40.0 bits (92), Expect = 0.002
Identities = 51/191 (26%), Positives = 82/191 (42%), Gaps = 9/191 (4%)
Query: 1 MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIA 60
+ +SLKK ES + D+ D + N + F L I Q ++K V +
Sbjct: 344 LRRSLKKYSFESIREESSYSDIPD--VKN----DFAFMLHLIDQYDPLYSKRFAVFLSEV 397
Query: 61 ELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNN 120
L LN N + Q + L L + L+ +P L LEVL L
Sbjct: 398 SENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLEL-- 455
Query: 121 LSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK-LQILSLRDNDLISLPKEIGEL 179
+ + ++P + LT L+ L+L +I P + L + L+ L ++ D+ +P I L
Sbjct: 456 IPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSL 515
Query: 180 TQLKELHIQGN 190
L+ELH+ GN
Sbjct: 516 KTLEELHLTGN 526
Score = 28.9 bits (63), Expect = 5.2
Identities = 16/54 (29%), Positives = 27/54 (50%)
Query: 149 LPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 202
+P + L +L++L L +++P I +LT LKEL + + P L L
Sbjct: 438 IPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFL 491
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 109 bits (272), Expect = 3e-24
Identities = 67/186 (36%), Positives = 100/186 (53%), Gaps = 4/186 (2%)
Query: 16 NQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQI 75
N E+D+ D + + ++ L +T L L +N + +P I L NLE L N+I
Sbjct: 615 NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674
Query: 76 EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 135
E++PTQ+ +KL++L+L N L LP G L L+ L +T N + +LP F
Sbjct: 675 EKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRI--ETLPPELFQCRK 732
Query: 136 LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKE--LHIQGNRLT 193
LRAL+L +N + LP +G+LT L + LR N L LP E+GE LK L ++ +
Sbjct: 733 LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFN 792
Query: 194 VLPPEL 199
LPPE+
Sbjct: 793 TLPPEV 798
Score = 59.7 bits (143), Expect = 3e-09
Identities = 54/187 (28%), Positives = 81/187 (43%), Gaps = 26/187 (13%)
Query: 41 HITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISS----LQKLKHLNLGMN 96
H+T + + N +V + ELK L+VL +N + +LP ++ LQKL N G
Sbjct: 522 HLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTK 580
Query: 97 R---------------------LNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 135
L +P SL L+ +DL NNL +F +L
Sbjct: 581 LIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHR 640
Query: 136 LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVL 195
L L L N +P IG LT L+ L L N + +P ++ +L+ L + N LT L
Sbjct: 641 LTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFL 700
Query: 196 PPELGNL 202
P ++G L
Sbjct: 701 PADIGLL 707
Score = 40.0 bits (92), Expect = 0.002
Identities = 51/191 (26%), Positives = 82/191 (42%), Gaps = 9/191 (4%)
Query: 1 MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIA 60
+ +SLKK ES + D+ D + N + F L I Q ++K V +
Sbjct: 344 LRRSLKKYSFESIREESSYSDIPD--VKN----DFAFMLHLIDQYDPLYSKRFAVFLSEV 397
Query: 61 ELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNN 120
L LN N + Q + L L + L+ +P L LEVL L
Sbjct: 398 SENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLEL-- 455
Query: 121 LSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK-LQILSLRDNDLISLPKEIGEL 179
+ + ++P + LT L+ L+L +I P + L + L+ L ++ D+ +P I L
Sbjct: 456 IPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSL 515
Query: 180 TQLKELHIQGN 190
L+ELH+ GN
Sbjct: 516 KTLEELHLTGN 526
Score = 28.9 bits (63), Expect = 5.2
Identities = 16/54 (29%), Positives = 27/54 (50%)
Query: 149 LPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 202
+P + L +L++L L +++P I +LT LKEL + + P L L
Sbjct: 438 IPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFL 491
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 109 bits (272), Expect = 3e-24
Identities = 72/196 (36%), Positives = 102/196 (52%), Gaps = 10/196 (5%)
Query: 19 EVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEEL 78
E+D+ + I N+ + G L H+ L L N+L+ +P I LKNL L+ N++E L
Sbjct: 178 ELDLGNNEIYNLPESIG--ALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERL 235
Query: 79 PTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRA 138
P +IS L L L + N L T+P G G L L +L + N L++ LP +L
Sbjct: 236 PEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQ--LPEAVGECESLTE 293
Query: 139 LYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPE 198
L L++N LP IGKL KL L+ N L+SLPKEIG L ++ NRLT +P E
Sbjct: 294 LVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAE 353
Query: 199 LGN------LDLTGQK 208
+ LD+ G +
Sbjct: 354 VSQATELHVLDVAGNR 369
Score = 107 bits (266), Expect = 1e-23
Identities = 66/164 (40%), Positives = 91/164 (55%), Gaps = 2/164 (1%)
Query: 39 LSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 98
L ++ L L N LT +P ++ +L+ LE L+ NN+I LP I +L LK L L N+L
Sbjct: 150 LYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQL 209
Query: 99 NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 158
+ LP+ G+L L LD++ N L LP LT+L L +S N E +P IGKL K
Sbjct: 210 SELPQEIGNLKNLLCLDVSENRLER--LPEEISGLTSLTDLVISQNLLETIPDGIGKLKK 267
Query: 159 LQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 202
L IL + N L LP+ +GE L EL + N+L LP +G L
Sbjct: 268 LSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKL 311
Score = 102 bits (255), Expect = 3e-22
Identities = 66/180 (36%), Positives = 97/180 (53%), Gaps = 9/180 (5%)
Query: 30 MLDVNGL-------FTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQI 82
+LD N L F L + +L LS N++ +PP IA L L+ N+I E+P I
Sbjct: 42 LLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESI 101
Query: 83 SSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLS 142
S + L+ + N L LP F L L L + N++S SLP N L L +L L
Sbjct: 102 SFCKALQVADFSGNPLTRLPESFPELQNLTCLSV--NDISLQSLPENIGNLYNLASLELR 159
Query: 143 DNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 202
+N LP + +L +L+ L L +N++ +LP+ IG L LK+L + GN+L+ LP E+GNL
Sbjct: 160 ENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNL 219
Score = 87.8 bits (216), Expect = 9e-18
Identities = 56/167 (33%), Positives = 88/167 (52%), Gaps = 2/167 (1%)
Query: 34 NGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNL 93
+ L L + +L L +N++ +P +I L +L+ L NQ+ ELP +I +L+ L L++
Sbjct: 168 DSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDV 227
Query: 94 GMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDI 153
NRL LP L +L L ++ N L ++P L L L + N LP +
Sbjct: 228 SENRLERLPEEISGLTSLTDLVISQNLL--ETIPDGIGKLKKLSILKVDQNRLTQLPEAV 285
Query: 154 GKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELG 200
G+ L L L +N L++LPK IG+L +L L+ N+L LP E+G
Sbjct: 286 GECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIG 332
Score = 54.7 bits (130), Expect = 9e-08
Identities = 39/108 (36%), Positives = 56/108 (51%), Gaps = 3/108 (2%)
Query: 42 ITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTL 101
+T+LVL+ N+L +P +I +LK L LN N++ LP +I L + NRL +
Sbjct: 291 LTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRI 350
Query: 102 PRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEIL 149
P L VLD+ N L LP + L L+AL+LSDN + L
Sbjct: 351 PAEVSQATELHVLDVAGNRLLH--LPLSLTAL-KLKALWLSDNQSQPL 395
Score = 44.7 bits (104), Expect = 9e-05
Identities = 24/68 (35%), Positives = 33/68 (48%)
Query: 132 YLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNR 191
Y +L L L N LP +L KL+ L L DN++ LP EI QL EL + N
Sbjct: 34 YARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNE 93
Query: 192 LTVLPPEL 199
+ +P +
Sbjct: 94 IPEIPESI 101
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 108 bits (270), Expect = 5e-24
Identities = 72/207 (34%), Positives = 112/207 (54%), Gaps = 8/207 (3%)
Query: 35 GLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLG 94
G LS++ L LS+N LT VP + + L +L LN +N+++ LP +I+ +++LKHL+
Sbjct: 169 GFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCN 228
Query: 95 MNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPD-I 153
N L T+P + +LE+L L N L LP F + L+ L++ +N E+L + +
Sbjct: 229 SNLLETIPPELAGMESLELLYLRRNKL--RFLP-EFPSCSLLKELHVGENQIEMLEAEHL 285
Query: 154 GKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKA 213
L + +L LRDN L S+P EI L L+ L + N ++ LP LGNL L +
Sbjct: 286 KHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHL----KFLAL 341
Query: 214 ENNPWVTPIADQFQLGVSHVFEYIRSE 240
E NP T + G V +Y+RS+
Sbjct: 342 EGNPLRTIRREIISKGTQEVLKYLRSK 368
Score = 98.6 bits (244), Expect = 5e-21
Identities = 58/158 (36%), Positives = 97/158 (61%), Gaps = 2/158 (1%)
Query: 39 LSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 98
L +T L + N+LT +P I EL+NL+ LN +N+++ LP +I++L+ LK L L N L
Sbjct: 104 LPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNEL 163
Query: 99 NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 158
+ GF L LE LDL+ N+L+ ++P +F L++L L LS N+ + LP +I ++ +
Sbjct: 164 TCISEGFEQLSNLEDLDLSNNHLT--TVPASFSSLSSLVRLNLSSNELKSLPAEINRMKR 221
Query: 159 LQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLP 196
L+ L N L ++P E+ + L+ L+++ N+L LP
Sbjct: 222 LKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP 259
Score = 96.3 bits (238), Expect = 3e-20
Identities = 57/162 (35%), Positives = 89/162 (54%), Gaps = 2/162 (1%)
Query: 42 ITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTL 101
+T+L++S+NKL + ++ L L VL+ +NQ+ LP+ I L+ L+ LN+ N+L L
Sbjct: 84 LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKIL 143
Query: 102 PRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQI 161
P +L L+ L L +N L+ + F L+ L L LS+N +P L+ L
Sbjct: 144 PEEITNLRNLKCLYLQHNELT--CISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVR 201
Query: 162 LSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLD 203
L+L N+L SLP EI + +LK L N L +PPEL ++
Sbjct: 202 LNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGME 243
Score = 74.3 bits (181), Expect = 1e-13
Identities = 47/155 (30%), Positives = 82/155 (52%), Gaps = 4/155 (2%)
Query: 42 ITQLVLSHNKLTMVPPNIAELKNL-EVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNT 100
+T + S N+L +P + ELK + ++ N++ + ++ LQKL L+L N LN+
Sbjct: 427 VTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNS 486
Query: 101 LPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK-L 159
LP SL L+ ++L++N LP + + TL + +S+N + P K+ + L
Sbjct: 487 LPEEMESLVRLQTINLSFNRFK--MLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENL 544
Query: 160 QILSLRDNDLISLPKEIGELTQLKELHIQGNRLTV 194
L L++NDL+ +P E+G L+ L + GN V
Sbjct: 545 TTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFRV 579
Score = 62.0 bits (149), Expect = 5e-10
Identities = 61/219 (27%), Positives = 98/219 (44%), Gaps = 26/219 (11%)
Query: 30 MLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLK 89
ML+ L L+ I L L NKL VP I L++LE L+ NN I LP + +L LK
Sbjct: 279 MLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLH-LK 337
Query: 90 HLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSEN-------------SLPG----NFFY 132
L L N L T+ R S EVL + + ++ +LP N
Sbjct: 338 FLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHA 397
Query: 133 LTTLRALYLSDNDFEILPPDIGKLTKLQI---LSLRDNDLISLPKEIGELTQL-KELHIQ 188
+ TL+ L SD ++P ++ K I ++ N L +PK + EL ++ ++ +
Sbjct: 398 IITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLS 457
Query: 189 GNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQ 227
N+L+ + EL L QK F N ++ + ++ +
Sbjct: 458 FNKLSFISLELCVL----QKLTFLDLRNNFLNSLPEEME 492
Score = 57.0 bits (136), Expect = 2e-08
Identities = 37/121 (30%), Positives = 64/121 (52%), Gaps = 2/121 (1%)
Query: 82 ISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYL 141
+ + +K LNL L+ +P+ + +++ + NLS + ++ T L L +
Sbjct: 32 LKAARKSGQLNLSGRNLSEVPQCVWRIN-VDIPEEANQNLSFGATE-RWWEQTDLTKLII 89
Query: 142 SDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGN 201
S+N + L D+ L L +L + DN L SLP I EL L++L++ N+L +LP E+ N
Sbjct: 90 SNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITN 149
Query: 202 L 202
L
Sbjct: 150 L 150
Score = 55.1 bits (131), Expect = 7e-08
Identities = 53/209 (25%), Positives = 89/209 (42%), Gaps = 33/209 (15%)
Query: 58 NIAELKNLEVLNFFNNQIEELPTQISSLQK---LKHLNLGMNRLNTLPRGFGSLPAL-EV 113
NI + L++L++ + Q +P ++ K + +N N+L +P+ L +
Sbjct: 394 NIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSD 453
Query: 114 LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP 173
+DL++N LS SL L L L L +N LP ++ L +LQ ++L N LP
Sbjct: 454 VDLSFNKLSFISL--ELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLP 511
Query: 174 K----------------EIGE--------LTQLKELHIQGNRLTVLPPELGNLDLTGQKQ 209
+ ++G + L L +Q N L +PPELGN +
Sbjct: 512 EVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGN---CVNLR 568
Query: 210 VFKAENNPWVTPIADQFQLGVSHVFEYIR 238
+ NP+ P A G + + EY+R
Sbjct: 569 TLLLDGNPFRVPRAAILMKGTAAILEYLR 597
Score = 47.4 bits (111), Expect = 1e-05
Identities = 37/98 (37%), Positives = 49/98 (50%), Gaps = 6/98 (6%)
Query: 112 EVLDLTYNNLSEN---SLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDND 168
E DLT +S N SL + L L L + DN LP I +L LQ L++ N
Sbjct: 80 EQTDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNK 139
Query: 169 LISLPKEIGELTQLKELHIQGNRLTVLP---PELGNLD 203
L LP+EI L LK L++Q N LT + +L NL+
Sbjct: 140 LKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLE 177
Score = 33.5 bits (75), Expect = 0.21
Identities = 23/83 (27%), Positives = 40/83 (48%), Gaps = 1/83 (1%)
Query: 38 TLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEEL-PTQISSLQKLKHLNLGMN 96
+L + + LS N+ M+P + + LE + NNQ+ + P ++ ++ L L+L N
Sbjct: 493 SLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNN 552
Query: 97 RLNTLPRGFGSLPALEVLDLTYN 119
L +P G+ L L L N
Sbjct: 553 DLLQIPPELGNCVNLRTLLLDGN 575
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 107 bits (268), Expect = 9e-24
Identities = 74/218 (33%), Positives = 106/218 (48%), Gaps = 26/218 (11%)
Query: 19 EVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEEL 78
++D+ + + D G L ++ +L L N+L+ +PP + L+ L L+ N++EEL
Sbjct: 178 QLDLGGNDLEVLPDTLG--ALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEEL 235
Query: 79 PTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSE--------------- 123
P ++ L L L L N L LP G G L L +L + N L E
Sbjct: 236 PAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELI 295
Query: 124 ------NSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIG 177
+LP + LT L L + N E LPP+IG L +LSLRDN L LP E+
Sbjct: 296 LTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELA 355
Query: 178 ELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAEN 215
T+L L + GNRL LP L +L+L K ++ AEN
Sbjct: 356 HTTELHVLDVAGNRLQSLPFALTHLNL---KALWLAEN 390
Score = 102 bits (254), Expect = 4e-22
Identities = 68/180 (37%), Positives = 96/180 (53%), Gaps = 9/180 (5%)
Query: 30 MLDVNGL-------FTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQI 82
+LD N L F L ++ +L LS N++ +PP +A L L+ N I E+P I
Sbjct: 42 LLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESI 101
Query: 83 SSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLS 142
+ L+ + N L+ LP GF L +L L L N++S +LPG+ L L L L
Sbjct: 102 KFCKALEIADFSGNPLSRLPDGFTQLRSLAHLAL--NDVSLQALPGDVGNLANLVTLELR 159
Query: 143 DNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 202
+N + LP + L KL+ L L NDL LP +G L L+EL + N+L+ LPPELGNL
Sbjct: 160 ENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNL 219
Score = 98.6 bits (244), Expect = 5e-21
Identities = 63/163 (38%), Positives = 85/163 (52%), Gaps = 2/163 (1%)
Query: 42 ITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTL 101
+ +L +S N + +P +I K LE+ +F N + LP + L+ L HL L L L
Sbjct: 84 LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQAL 143
Query: 102 PRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQI 161
P G+L L L+L N L SLP + +L L L L ND E+LP +G L L+
Sbjct: 144 PGDVGNLANLVTLELRENLLK--SLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRE 201
Query: 162 LSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDL 204
L L N L +LP E+G L +L L + NRL LP ELG L L
Sbjct: 202 LWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVL 244
Score = 96.7 bits (239), Expect = 2e-20
Identities = 58/161 (36%), Positives = 87/161 (54%), Gaps = 2/161 (1%)
Query: 42 ITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTL 101
+ +L+L N+L +P L NL L +N+I+ LP ++++ +L L++ N + +
Sbjct: 38 LEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEI 97
Query: 102 PRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQI 161
P ALE+ D + N LS LP F L +L L L+D + LP D+G L L
Sbjct: 98 PESIKFCKALEIADFSGNPLSR--LPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVT 155
Query: 162 LSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 202
L LR+N L SLP + L +L++L + GN L VLP LG L
Sbjct: 156 LELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGAL 196
Score = 91.7 bits (226), Expect = 6e-19
Identities = 63/185 (34%), Positives = 92/185 (49%), Gaps = 25/185 (13%)
Query: 39 LSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 98
L+++ L L N L +P +++ L LE L+ N +E LP + +L L+ L L N+L
Sbjct: 150 LANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQL 209
Query: 99 NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 158
+ LP G+L L LD++ N L E LP L L L LS N LP IG+L +
Sbjct: 210 SALPPELGNLRRLVCLDVSENRLEE--LPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQ 267
Query: 159 LQILS-----------------------LRDNDLISLPKEIGELTQLKELHIQGNRLTVL 195
L IL L +N L++LP+ +G+LT+L L++ N L L
Sbjct: 268 LSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEAL 327
Query: 196 PPELG 200
PPE+G
Sbjct: 328 PPEIG 332
Score = 40.8 bits (94), Expect = 0.001
Identities = 22/68 (32%), Positives = 32/68 (47%)
Query: 132 YLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNR 191
Y +L L L N LP +L L+ L L DN++ LP E+ QL EL + N
Sbjct: 34 YSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRND 93
Query: 192 LTVLPPEL 199
+ +P +
Sbjct: 94 IPEIPESI 101
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 107 bits (268), Expect = 9e-24
Identities = 74/218 (33%), Positives = 106/218 (48%), Gaps = 26/218 (11%)
Query: 19 EVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEEL 78
++D+ + + D G L ++ +L L N+L+ +PP + L+ L L+ N++EEL
Sbjct: 178 QLDLGGNDLEVLPDTLG--ALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEEL 235
Query: 79 PTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSE--------------- 123
P ++ L L L L N L LP G G L L +L + N L E
Sbjct: 236 PAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELI 295
Query: 124 ------NSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIG 177
+LP + LT L L + N E LPP+IG L +LSLRDN L LP E+
Sbjct: 296 LTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELA 355
Query: 178 ELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAEN 215
T+L L + GNRL LP L +L+L K ++ AEN
Sbjct: 356 HTTELHVLDVAGNRLQSLPFALTHLNL---KALWLAEN 390
Score = 102 bits (254), Expect = 4e-22
Identities = 68/180 (37%), Positives = 96/180 (53%), Gaps = 9/180 (5%)
Query: 30 MLDVNGL-------FTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQI 82
+LD N L F L ++ +L LS N++ +PP +A L L+ N I E+P I
Sbjct: 42 LLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESI 101
Query: 83 SSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLS 142
+ L+ + N L+ LP GF L +L L L N++S +LPG+ L L L L
Sbjct: 102 KFCKALEIADFSGNPLSRLPDGFTQLRSLAHLAL--NDVSLQALPGDVGNLANLVTLELR 159
Query: 143 DNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 202
+N + LP + L KL+ L L NDL LP +G L L+EL + N+L+ LPPELGNL
Sbjct: 160 ENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNL 219
Score = 98.6 bits (244), Expect = 5e-21
Identities = 63/163 (38%), Positives = 85/163 (52%), Gaps = 2/163 (1%)
Query: 42 ITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTL 101
+ +L +S N + +P +I K LE+ +F N + LP + L+ L HL L L L
Sbjct: 84 LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQAL 143
Query: 102 PRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQI 161
P G+L L L+L N L SLP + +L L L L ND E+LP +G L L+
Sbjct: 144 PGDVGNLANLVTLELRENLLK--SLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRE 201
Query: 162 LSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDL 204
L L N L +LP E+G L +L L + NRL LP ELG L L
Sbjct: 202 LWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVL 244
Score = 96.7 bits (239), Expect = 2e-20
Identities = 58/161 (36%), Positives = 87/161 (54%), Gaps = 2/161 (1%)
Query: 42 ITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTL 101
+ +L+L N+L +P L NL L +N+I+ LP ++++ +L L++ N + +
Sbjct: 38 LEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEI 97
Query: 102 PRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQI 161
P ALE+ D + N LS LP F L +L L L+D + LP D+G L L
Sbjct: 98 PESIKFCKALEIADFSGNPLSR--LPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVT 155
Query: 162 LSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 202
L LR+N L SLP + L +L++L + GN L VLP LG L
Sbjct: 156 LELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGAL 196
Score = 91.7 bits (226), Expect = 6e-19
Identities = 63/185 (34%), Positives = 92/185 (49%), Gaps = 25/185 (13%)
Query: 39 LSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 98
L+++ L L N L +P +++ L LE L+ N +E LP + +L L+ L L N+L
Sbjct: 150 LANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQL 209
Query: 99 NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 158
+ LP G+L L LD++ N L E LP L L L LS N LP IG+L +
Sbjct: 210 SALPPELGNLRRLVCLDVSENRLEE--LPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQ 267
Query: 159 LQILS-----------------------LRDNDLISLPKEIGELTQLKELHIQGNRLTVL 195
L IL L +N L++LP+ +G+LT+L L++ N L L
Sbjct: 268 LSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEAL 327
Query: 196 PPELG 200
PPE+G
Sbjct: 328 PPEIG 332
Score = 40.8 bits (94), Expect = 0.001
Identities = 22/68 (32%), Positives = 32/68 (47%)
Query: 132 YLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNR 191
Y +L L L N LP +L L+ L L DN++ LP E+ QL EL + N
Sbjct: 34 YSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRND 93
Query: 192 LTVLPPEL 199
+ +P +
Sbjct: 94 IPEIPESI 101
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 107 bits (267), Expect = 1e-23
Identities = 83/241 (34%), Positives = 118/241 (48%), Gaps = 30/241 (12%)
Query: 19 EVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEEL 78
E+D+S ++++ D L LS + L + HN+LT P + +L LE L+ +N++ L
Sbjct: 162 ELDVSFNRLAHLPD--SLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGL 219
Query: 79 PTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRA 138
P IS+L+ LK L L L TLP GF L +LE L L N L +LP F L L+
Sbjct: 220 PEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGL--QALPAQFSCLQRLKM 277
Query: 139 LYLSDNDFEILPPDIGKLTKLQILSLRDNDLIS-----------------------LPKE 175
L LS N FE P + L L+ L L N L S LP
Sbjct: 278 LNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDS 337
Query: 176 IGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHVFE 235
I ELT L+EL +QGN++ VLP G L G ++K ++NP + P + G+ ++
Sbjct: 338 IVELTGLEELVLQGNQIAVLPDHFGQLSRVG---LWKIKDNPLIQPPYEVCMKGIPYIAA 394
Query: 236 Y 236
Y
Sbjct: 395 Y 395
Score = 90.5 bits (223), Expect = 1e-18
Identities = 63/197 (31%), Positives = 102/197 (51%), Gaps = 5/197 (2%)
Query: 19 EVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEEL 78
E+D+S ++ L + L + +L LSHN+L +P + L +LE L+ N++ L
Sbjct: 115 ELDVSHNRLT-ALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHL 173
Query: 79 PTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRA 138
P +S L +L+ L++ N+L PR L ALE LD++ N L LP + L L+
Sbjct: 174 PDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRL--RGLPEDISALRALKI 231
Query: 139 LYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPE 198
L+LS + LP +L L+ L L +N L +LP + L +LK L++ N P
Sbjct: 232 LWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAA 291
Query: 199 LGNLDLTGQKQVFKAEN 215
L L L G ++++ + N
Sbjct: 292 L--LPLAGLEELYLSRN 306
Score = 84.3 bits (207), Expect = 1e-16
Identities = 59/170 (34%), Positives = 92/170 (54%), Gaps = 7/170 (4%)
Query: 39 LSHITQLVLSHNKLTMVPPNIAEL-KNLEVLNFFNNQIEELPTQ-ISSLQKLKHLNLGMN 96
L + LVL N+ +PP +AEL +L L+ +N++ L + +S+L++L+ LNL N
Sbjct: 86 LGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLSHN 145
Query: 97 RLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKL 156
+L LP G+L LE LD+++N L+ LP + L+ LR L + N P + +L
Sbjct: 146 QLPALPAQLGALAHLEELDVSFNRLAH--LPDSLSCLSRLRTLDVDHNQLTAFPRQLLQL 203
Query: 157 TKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPP---ELGNLD 203
L+ L + N L LP++I L LK L + G L LP EL +L+
Sbjct: 204 VALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLE 253
Score = 52.8 bits (125), Expect = 3e-07
Identities = 45/141 (31%), Positives = 64/141 (45%), Gaps = 24/141 (17%)
Query: 83 SSLQKLKHLNLGMNRLNTLPRGFGS-LPALEVLDLTYN--------------NLSENSLP 127
++L ++ LNLG N L +P G GS L +L VL L N +L+E +
Sbjct: 60 ANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVS 119
Query: 128 GN---------FFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGE 178
N L LR L LS N LP +G L L+ L + N L LP +
Sbjct: 120 HNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSC 179
Query: 179 LTQLKELHIQGNRLTVLPPEL 199
L++L+ L + N+LT P +L
Sbjct: 180 LSRLRTLDVDHNQLTAFPRQL 200
>gi|154091020 leucine-rich repeats and calponin homology (CH) domain
containing 2 [Homo sapiens]
Length = 765
Score = 106 bits (265), Expect = 2e-23
Identities = 76/225 (33%), Positives = 119/225 (52%), Gaps = 16/225 (7%)
Query: 22 MSDRGISNMLDVNGL---------FTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFN 72
+ + G S +L ++G + L+ TQ LS N+ T +P ++ LE LN ++
Sbjct: 84 LEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYH 143
Query: 73 NQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFY 132
N I+ +P I +LQ L +LN+ N L+TLP+ LP L+VL ++ N L S+P
Sbjct: 144 NCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLV--SIPEEIGK 200
Query: 133 LTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRL 192
L L L +S N+ ++LP +GKL L+ L++R N+L LP E+G+L +K L N++
Sbjct: 201 LKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVK-LDFSCNKV 259
Query: 193 TVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHVFEYI 237
T +P L QV +NNP P A G H+F+Y+
Sbjct: 260 TEIPVCYRKLH---HLQVIILDNNPLQVPPAQICLKGKVHIFKYL 301
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 105 bits (261), Expect = 6e-23
Identities = 75/196 (38%), Positives = 95/196 (48%), Gaps = 24/196 (12%)
Query: 42 ITQLVLSHNKLTMVPPNIAEL-KNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNT 100
+T L SH L VP I K LE L NQIEELP Q+ + Q L L+L N L T
Sbjct: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
Query: 101 LPRGFGSLPALEVLDLTYNNLSE---------------------NSLPGNFFYLTTLRAL 139
LP +L L LD++ N + E + LP F L L L
Sbjct: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143
Query: 140 YLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPEL 199
YL+D E LP + G+LTKLQIL LR+N L LPK + LTQL+ L + N T +P L
Sbjct: 144 YLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
Query: 200 GNLDLTGQKQVFKAEN 215
L+G K+ + N
Sbjct: 204 E--QLSGLKEFWMDAN 217
Score = 98.6 bits (244), Expect = 5e-21
Identities = 59/167 (35%), Positives = 91/167 (54%), Gaps = 2/167 (1%)
Query: 36 LFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGM 95
LF + +L L N LT +P +IA L NL L+ N I+E P I + + L + +
Sbjct: 65 LFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASV 124
Query: 96 NRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGK 155
N ++ LP GF L L + L N+ LP NF LT L+ L L +N ++LP + +
Sbjct: 125 NPISKLPDGFSQL--LNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNR 182
Query: 156 LTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 202
LT+L+ L L N+ +P+ + +L+ LKE + NRLT +P +G+L
Sbjct: 183 LTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSL 229
Score = 98.6 bits (244), Expect = 5e-21
Identities = 55/159 (34%), Positives = 90/159 (56%), Gaps = 2/159 (1%)
Query: 38 TLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNR 97
+L +T L +S N + MV I+ +NL+ L +N +++LP I SL+ + L + N+
Sbjct: 228 SLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQ 287
Query: 98 LNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLT 157
L LP G L ++E LD ++N + +LP + LT LR N + LPP+IG
Sbjct: 288 LMYLPDSIGGLISVEELDCSFNEVE--ALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWK 345
Query: 158 KLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLP 196
+ +L L N L +LP+E+G++ +LK +++ NRL LP
Sbjct: 346 NITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP 384
Score = 91.7 bits (226), Expect = 6e-19
Identities = 64/207 (30%), Positives = 94/207 (45%), Gaps = 13/207 (6%)
Query: 4 SLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELK 63
SLK+L KN ++M + GIS T ++ L+LS N L +P I LK
Sbjct: 228 SLKQLTYLDVSKNN--IEMVEEGIS---------TCENLQDLLLSSNSLQQLPETIGSLK 276
Query: 64 NLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSE 123
N+ L NQ+ LP I L ++ L+ N + LP G L L +N L +
Sbjct: 277 NITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQ 336
Query: 124 NSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLK 183
LP + L+L N E LP ++G + KL++++L DN L +LP +L QL
Sbjct: 337 --LPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLT 394
Query: 184 ELHIQGNRLTVLPPELGNLDLTGQKQV 210
+ + N+ L P D QK V
Sbjct: 395 AMWLSDNQSKPLIPLQKETDSETQKMV 421
Score = 86.3 bits (212), Expect = 3e-17
Identities = 57/178 (32%), Positives = 86/178 (48%), Gaps = 5/178 (2%)
Query: 39 LSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 98
L+ + L L N+L M+P + L LE L+ +N+ E+P + L LK + NRL
Sbjct: 160 LTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRL 219
Query: 99 NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 158
+P GSL L LD++ NN+ + L+ L LS N + LP IG L
Sbjct: 220 TFIPGFIGSLKQLTYLDVSKNNI--EMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKN 277
Query: 159 LQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENN 216
+ L + +N L+ LP IG L ++EL N + LP +G L + F A++N
Sbjct: 278 ITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLT---NLRTFAADHN 332
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 105 bits (261), Expect = 6e-23
Identities = 75/196 (38%), Positives = 95/196 (48%), Gaps = 24/196 (12%)
Query: 42 ITQLVLSHNKLTMVPPNIAEL-KNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNT 100
+T L SH L VP I K LE L NQIEELP Q+ + Q L L+L N L T
Sbjct: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
Query: 101 LPRGFGSLPALEVLDLTYNNLSE---------------------NSLPGNFFYLTTLRAL 139
LP +L L LD++ N + E + LP F L L L
Sbjct: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143
Query: 140 YLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPEL 199
YL+D E LP + G+LTKLQIL LR+N L LPK + LTQL+ L + N T +P L
Sbjct: 144 YLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
Query: 200 GNLDLTGQKQVFKAEN 215
L+G K+ + N
Sbjct: 204 E--QLSGLKEFWMDAN 217
Score = 98.6 bits (244), Expect = 5e-21
Identities = 59/167 (35%), Positives = 91/167 (54%), Gaps = 2/167 (1%)
Query: 36 LFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGM 95
LF + +L L N LT +P +IA L NL L+ N I+E P I + + L + +
Sbjct: 65 LFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASV 124
Query: 96 NRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGK 155
N ++ LP GF L L + L N+ LP NF LT L+ L L +N ++LP + +
Sbjct: 125 NPISKLPDGFSQL--LNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNR 182
Query: 156 LTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 202
LT+L+ L L N+ +P+ + +L+ LKE + NRLT +P +G+L
Sbjct: 183 LTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSL 229
Score = 98.6 bits (244), Expect = 5e-21
Identities = 55/159 (34%), Positives = 90/159 (56%), Gaps = 2/159 (1%)
Query: 38 TLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNR 97
+L +T L +S N + MV I+ +NL+ L +N +++LP I SL+ + L + N+
Sbjct: 228 SLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQ 287
Query: 98 LNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLT 157
L LP G L ++E LD ++N + +LP + LT LR N + LPP+IG
Sbjct: 288 LMYLPDSIGGLISVEELDCSFNEVE--ALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWK 345
Query: 158 KLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLP 196
+ +L L N L +LP+E+G++ +LK +++ NRL LP
Sbjct: 346 NITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP 384
Score = 91.7 bits (226), Expect = 6e-19
Identities = 64/207 (30%), Positives = 94/207 (45%), Gaps = 13/207 (6%)
Query: 4 SLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELK 63
SLK+L KN ++M + GIS T ++ L+LS N L +P I LK
Sbjct: 228 SLKQLTYLDVSKNN--IEMVEEGIS---------TCENLQDLLLSSNSLQQLPETIGSLK 276
Query: 64 NLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSE 123
N+ L NQ+ LP I L ++ L+ N + LP G L L +N L +
Sbjct: 277 NITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQ 336
Query: 124 NSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLK 183
LP + L+L N E LP ++G + KL++++L DN L +LP +L QL
Sbjct: 337 --LPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLT 394
Query: 184 ELHIQGNRLTVLPPELGNLDLTGQKQV 210
+ + N+ L P D QK V
Sbjct: 395 AMWLSDNQSKPLIPLQKETDSETQKMV 421
Score = 86.3 bits (212), Expect = 3e-17
Identities = 57/178 (32%), Positives = 86/178 (48%), Gaps = 5/178 (2%)
Query: 39 LSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 98
L+ + L L N+L M+P + L LE L+ +N+ E+P + L LK + NRL
Sbjct: 160 LTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRL 219
Query: 99 NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 158
+P GSL L LD++ NN+ + L+ L LS N + LP IG L
Sbjct: 220 TFIPGFIGSLKQLTYLDVSKNNI--EMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKN 277
Query: 159 LQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENN 216
+ L + +N L+ LP IG L ++EL N + LP +G L + F A++N
Sbjct: 278 ITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLT---NLRTFAADHN 332
>gi|33859670 leucine-rich repeats and calponin homology (CH) domain
containing 1 [Homo sapiens]
Length = 728
Score = 103 bits (258), Expect = 1e-22
Identities = 79/253 (31%), Positives = 117/253 (46%), Gaps = 55/253 (21%)
Query: 39 LSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 98
LS Q LS N+L VP + +LE+LN ++N I +P I +LQ L +LNL N+L
Sbjct: 96 LSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQL 155
Query: 99 NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 158
+ LP LP L+ L S+N LP +IG+L +
Sbjct: 156 SALPACLCGLP--------------------------LKVLIASNNKLGSLPEEIGQLKQ 189
Query: 159 LQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLT------------- 205
L L + N++ +LP++IG+L L+EL+++ N L VLP EL +L L
Sbjct: 190 LMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDFSCNKVLVIP 249
Query: 206 ------GQKQVFKAENNPWVTPIADQFQLGVSHVFEY-------IRSETYKYLYGR---H 249
Q QV ENNP +P A G H+F+Y I++ YL+ H
Sbjct: 250 ICFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSLYLHTMERPH 309
Query: 250 MQANPEPPKKNND 262
+ + E KK++D
Sbjct: 310 LHQHVEDGKKDSD 322
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 102 bits (254), Expect = 4e-22
Identities = 66/196 (33%), Positives = 104/196 (53%), Gaps = 4/196 (2%)
Query: 7 KLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLE 66
K + + RE+N +D+S R I + + + L+ +T+L L NKL +P + L NL
Sbjct: 92 KELNKCREENSMRLDLSKRSIHIL--PSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLM 149
Query: 67 VLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSL 126
L N + LP + +L+KL+ L+L N+L +P L +L L L +N ++ ++
Sbjct: 150 TLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRIT--TV 207
Query: 127 PGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELH 186
+ L+ L L + +N + LP +IG+L L L + N L LPKEIG TQ+ L
Sbjct: 208 EKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLD 267
Query: 187 IQGNRLTVLPPELGNL 202
+Q N L LP +GNL
Sbjct: 268 LQHNELLDLPDTIGNL 283
Score = 98.2 bits (243), Expect = 7e-21
Identities = 67/180 (37%), Positives = 90/180 (50%), Gaps = 3/180 (1%)
Query: 25 RGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNI-AELKNLEVLNFFNNQIEELPTQIS 83
R + V G S I L + HN++ +P I + K L LN +NQ+ LP
Sbjct: 340 RNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFG 399
Query: 84 SLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSD 143
+ + LNL N+L +P L +LEVL L+ N L + LP L LR L L +
Sbjct: 400 TWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKK--LPHGLGNLRKLRELDLEE 457
Query: 144 NDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLD 203
N E LP +I L LQ L L +N L +LP+ IG LT L L + N LT LP E+G L+
Sbjct: 458 NKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLE 517
Score = 96.7 bits (239), Expect = 2e-20
Identities = 68/190 (35%), Positives = 111/190 (58%), Gaps = 7/190 (3%)
Query: 12 SREKNQPEVDMSDRGISNM-LDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNF 70
SR K +++M D ++++ LD T + + +L L+ N+LT +P +++ L +LEVL
Sbjct: 376 SRAKVLSKLNMKDNQLTSLPLDFG---TWTSMVELNLATNQLTKIPEDVSGLVSLEVLIL 432
Query: 71 FNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNF 130
NN +++LP + +L+KL+ L+L N+L +LP L L+ L LT N L+ +LP
Sbjct: 433 SNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLT--TLPRGI 490
Query: 131 FYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDN-DLISLPKEIGELTQLKELHIQG 189
+LT L L L +N LP +IG L L+ L L DN +L SLP E+ ++L + I+
Sbjct: 491 GHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIEN 550
Query: 190 NRLTVLPPEL 199
L+ LPP++
Sbjct: 551 CPLSHLPPQI 560
Score = 86.3 bits (212), Expect = 3e-17
Identities = 56/178 (31%), Positives = 90/178 (50%), Gaps = 4/178 (2%)
Query: 22 MSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQ 81
+S+ ++++ D L L + L L HNKL +P + L +L L N+I +
Sbjct: 153 LSENSLTSLPD--SLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKD 210
Query: 82 ISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYL 141
I +L KL L++ N++ LP G L L LD+ +N L LP T + L L
Sbjct: 211 IKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEH--LPKEIGNCTQITNLDL 268
Query: 142 SDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPEL 199
N+ LP IG L+ L L LR N L ++P+ + + + L+EL+++ N ++ LP L
Sbjct: 269 QHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESL 326
Score = 78.6 bits (192), Expect = 6e-15
Identities = 62/213 (29%), Positives = 96/213 (45%), Gaps = 51/213 (23%)
Query: 39 LSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQ----------------- 81
LS ++ L + NK+ +P I EL NL L+ +NQ+E LP +
Sbjct: 214 LSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNEL 273
Query: 82 ------ISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFF-YLT 134
I +L L L L NRL+ +PR ALE L+L NN+S +LP + L
Sbjct: 274 LDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNIS--TLPESLLSSLV 331
Query: 135 TLRALYLSDNDFEILPP----------------------DIGKLTKLQILS---LRDNDL 169
L +L L+ N F++ P G ++ ++LS ++DN L
Sbjct: 332 KLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQL 391
Query: 170 ISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 202
SLP + G T + EL++ N+LT +P ++ L
Sbjct: 392 TSLPLDFGTWTSMVELNLATNQLTKIPEDVSGL 424
Score = 55.1 bits (131), Expect = 7e-08
Identities = 32/90 (35%), Positives = 50/90 (55%), Gaps = 2/90 (2%)
Query: 114 LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP 173
LDL+ ++ + LP + LT L LYL N + LP ++G L L L+L +N L SLP
Sbjct: 105 LDLSKRSI--HILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLP 162
Query: 174 KEIGELTQLKELHIQGNRLTVLPPELGNLD 203
+ L +L+ L ++ N+L +P + LD
Sbjct: 163 DSLDNLKKLRMLDLRHNKLREIPSVVYRLD 192
>gi|14249428 leucine-rich repeats and calponin homology (CH) domain
containing 3 [Homo sapiens]
Length = 712
Score = 102 bits (253), Expect = 5e-22
Identities = 78/242 (32%), Positives = 122/242 (50%), Gaps = 9/242 (3%)
Query: 2 SKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAE 61
S+SL + +EE+ + +S R + L+ T+ LS N+L+ +P
Sbjct: 46 SRSLDRALEEAAVTGV--LSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACH 103
Query: 62 LKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNL 121
+LE LN + N I +P I +LQ L LN+ N+L+TLP +LP L+VL + N L
Sbjct: 104 FVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIASNNKL 162
Query: 122 SENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQ 181
SLP +L L L +S N+ + +P IG L L+ L++R N L+ LP+E+ EL
Sbjct: 163 V--SLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPL 220
Query: 182 LKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHVFEYIRSET 241
++ L N++T +P NL Q +NNP +P A G H+F+Y+ +
Sbjct: 221 IR-LDFSCNKITTIPVCYRNL---RHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNIQA 276
Query: 242 YK 243
K
Sbjct: 277 CK 278
>gi|197333692 leucine rich repeat containing 8 family, member B
[Homo sapiens]
Length = 803
Score = 100 bits (250), Expect = 1e-21
Identities = 65/198 (32%), Positives = 104/198 (52%), Gaps = 6/198 (3%)
Query: 34 NGLFTLSHITQLVLSHNKLTMVPPNIA--ELKNLEVLNFFNNQIEELPTQISSLQKLKHL 91
+ +F+L+++ +L L N L V I+ L+NL L ++N I +P QI +L L+ L
Sbjct: 602 HSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQL 661
Query: 92 NLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPP 151
+L N + LP L LDL+YN+L+ +P YL+ L+ +++N+ E+LP
Sbjct: 662 SLDHNNIENLPLQLFLCTKLHYLDLSYNHLT--FIPEEIQYLSNLQYFAVTNNNIEMLPD 719
Query: 152 DIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVF 211
+ + KLQ L L N L++L +GEL+ L L + GN L LPPEL + +
Sbjct: 720 GLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLI 779
Query: 212 KAEN--NPWVTPIADQFQ 227
EN N P+ ++ Q
Sbjct: 780 VEENLLNTLPLPVTERLQ 797
Score = 62.4 bits (150), Expect = 4e-10
Identities = 59/201 (29%), Positives = 85/201 (42%), Gaps = 29/201 (14%)
Query: 41 HITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQIS----SLQKL-------- 88
+++ VL TM +LKNL L + + + +P ++ SLQKL
Sbjct: 516 YLSGCVLPEQLSTMQLEGFQDLKNLRTL-YLKSSLSRIPQVVTDLLPSLQKLSLDNEGSK 574
Query: 89 -------------KHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 135
K L L L +P SL L LDL NNL +F +L
Sbjct: 575 LVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQN 634
Query: 136 LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVL 195
L L L N+ +P IG L+ L+ LSL N++ +LP ++ T+L L + N LT +
Sbjct: 635 LSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFI 694
Query: 196 PPELGNLDLTGQKQVFKAENN 216
P E+ L Q F NN
Sbjct: 695 PEEIQYL---SNLQYFAVTNN 712
Score = 37.4 bits (85), Expect = 0.014
Identities = 19/55 (34%), Positives = 32/55 (58%)
Query: 149 LPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLD 203
LP ++ +LT++++LSL + LP + +L LKEL + + L V P L L+
Sbjct: 432 LPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLE 486
Score = 37.0 bits (84), Expect = 0.019
Identities = 43/156 (27%), Positives = 72/156 (46%), Gaps = 18/156 (11%)
Query: 52 LTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPA- 110
L +P N+ EL +EVL+ +LP+ +S L LK L + + L L
Sbjct: 429 LNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEEN 488
Query: 111 LEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIG--------KLTKLQIL 162
L++L L + + + +P F+L L+ LYLS +LP + L L+ L
Sbjct: 489 LKILRLKFTEMGK--IPRWVFHLKNLKELYLSGC---VLPEQLSTMQLEGFQDLKNLRTL 543
Query: 163 SLRDNDLISLPKEIGEL---TQLKELHIQGNRLTVL 195
L+ + L +P+ + +L Q L +G++L VL
Sbjct: 544 YLK-SSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVL 578
>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
sapiens]
Length = 803
Score = 100 bits (250), Expect = 1e-21
Identities = 65/198 (32%), Positives = 104/198 (52%), Gaps = 6/198 (3%)
Query: 34 NGLFTLSHITQLVLSHNKLTMVPPNIA--ELKNLEVLNFFNNQIEELPTQISSLQKLKHL 91
+ +F+L+++ +L L N L V I+ L+NL L ++N I +P QI +L L+ L
Sbjct: 602 HSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQL 661
Query: 92 NLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPP 151
+L N + LP L LDL+YN+L+ +P YL+ L+ +++N+ E+LP
Sbjct: 662 SLDHNNIENLPLQLFLCTKLHYLDLSYNHLT--FIPEEIQYLSNLQYFAVTNNNIEMLPD 719
Query: 152 DIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVF 211
+ + KLQ L L N L++L +GEL+ L L + GN L LPPEL + +
Sbjct: 720 GLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLI 779
Query: 212 KAEN--NPWVTPIADQFQ 227
EN N P+ ++ Q
Sbjct: 780 VEENLLNTLPLPVTERLQ 797
Score = 62.4 bits (150), Expect = 4e-10
Identities = 59/201 (29%), Positives = 85/201 (42%), Gaps = 29/201 (14%)
Query: 41 HITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQIS----SLQKL-------- 88
+++ VL TM +LKNL L + + + +P ++ SLQKL
Sbjct: 516 YLSGCVLPEQLSTMQLEGFQDLKNLRTL-YLKSSLSRIPQVVTDLLPSLQKLSLDNEGSK 574
Query: 89 -------------KHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 135
K L L L +P SL L LDL NNL +F +L
Sbjct: 575 LVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQN 634
Query: 136 LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVL 195
L L L N+ +P IG L+ L+ LSL N++ +LP ++ T+L L + N LT +
Sbjct: 635 LSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFI 694
Query: 196 PPELGNLDLTGQKQVFKAENN 216
P E+ L Q F NN
Sbjct: 695 PEEIQYL---SNLQYFAVTNN 712
Score = 37.4 bits (85), Expect = 0.014
Identities = 19/55 (34%), Positives = 32/55 (58%)
Query: 149 LPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLD 203
LP ++ +LT++++LSL + LP + +L LKEL + + L V P L L+
Sbjct: 432 LPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLE 486
Score = 37.0 bits (84), Expect = 0.019
Identities = 43/156 (27%), Positives = 72/156 (46%), Gaps = 18/156 (11%)
Query: 52 LTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPA- 110
L +P N+ EL +EVL+ +LP+ +S L LK L + + L L
Sbjct: 429 LNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEEN 488
Query: 111 LEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIG--------KLTKLQIL 162
L++L L + + + +P F+L L+ LYLS +LP + L L+ L
Sbjct: 489 LKILRLKFTEMGK--IPRWVFHLKNLKELYLSGC---VLPEQLSTMQLEGFQDLKNLRTL 543
Query: 163 SLRDNDLISLPKEIGEL---TQLKELHIQGNRLTVL 195
L+ + L +P+ + +L Q L +G++L VL
Sbjct: 544 YLK-SSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVL 578
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 100 bits (249), Expect = 1e-21
Identities = 71/215 (33%), Positives = 107/215 (49%), Gaps = 4/215 (1%)
Query: 39 LSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 98
L ++ L LS N L P I LKNLEVL +N+I +LP+++ SL KLK L L N
Sbjct: 302 LVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEF 361
Query: 99 NTLPRGFGSLPALEVLDLTYNN-LSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLT 157
+ P SL +LE L + + +P + L +L+ LY+ +N E LP +G +
Sbjct: 362 LSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMP 421
Query: 158 KLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNP 217
L++L R N L LP I + LKEL ++ N LT LP NLD +V +NP
Sbjct: 422 NLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPE---NLDSLVNLKVLTLMDNP 478
Query: 218 WVTPIADQFQLGVSHVFEYIRSETYKYLYGRHMQA 252
P + G +++Y++ + + +QA
Sbjct: 479 MEEPPKEVCAEGNEAIWKYLKENRNRNIMATKIQA 513
Score = 92.0 bits (227), Expect = 5e-19
Identities = 61/153 (39%), Positives = 86/153 (56%), Gaps = 2/153 (1%)
Query: 48 SHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGS 107
S+ LT +P I LE ++ NNQIEE+P +I L+ ++ L L N L +L G
Sbjct: 33 SNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGL 92
Query: 108 LPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGK-LTKLQILSLRD 166
L +LE LDL+YN + +SL F L LR L L D + +P I K L L++L L
Sbjct: 93 LSSLESLDLSYNPIFSSSLVVVSF-LHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTG 151
Query: 167 NDLISLPKEIGELTQLKELHIQGNRLTVLPPEL 199
N L LPKEI T+L+E++++ N+ V P EL
Sbjct: 152 NHLKCLPKEIVNQTKLREIYLKRNQFEVFPQEL 184
Score = 85.5 bits (210), Expect = 5e-17
Identities = 57/179 (31%), Positives = 89/179 (49%), Gaps = 7/179 (3%)
Query: 39 LSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 98
L+ + + ++ N L ++P ++ + L VL+ +N + +P + L+K+ + L NRL
Sbjct: 210 LTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRL 269
Query: 99 NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 158
+PR +L +L L N + L G+F L LR L LS N P I L
Sbjct: 270 EKVPRLICRWTSLHLLYL--GNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKN 327
Query: 159 LQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLD-----LTGQKQVFK 212
L++L L DN + LP E+G L++LK L + GN P E+ +L GQ Q FK
Sbjct: 328 LEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFK 386
Score = 80.9 bits (198), Expect = 1e-15
Identities = 49/159 (30%), Positives = 85/159 (53%), Gaps = 3/159 (1%)
Query: 39 LSHITQLVLSHNKLTMVPPNIAE-LKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNR 97
L + +L L L +P I + L +LE+L N ++ LP +I + KL+ + L N+
Sbjct: 117 LHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQ 176
Query: 98 LNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLT 157
P+ L LE++DL N + ++P +LT L+ Y++ N+ +LP + + +
Sbjct: 177 FEVFPQELCVLYTLEIIDLDENKIG--AIPEEIGHLTGLQKFYMASNNLPVLPASLCQCS 234
Query: 158 KLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLP 196
+L +L L N L S+PK EL ++ E+ + GNRL +P
Sbjct: 235 QLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVP 273
Score = 32.7 bits (73), Expect = 0.36
Identities = 20/68 (29%), Positives = 33/68 (48%)
Query: 36 LFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGM 95
L ++ ++ L HN L +P I + + L+ L +N + LP + SL LK L L
Sbjct: 417 LGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMD 476
Query: 96 NRLNTLPR 103
N + P+
Sbjct: 477 NPMEEPPK 484
>gi|157743290 leucine rich repeat containing 30 [Homo sapiens]
Length = 301
Score = 98.2 bits (243), Expect = 7e-21
Identities = 73/247 (29%), Positives = 120/247 (48%), Gaps = 33/247 (13%)
Query: 25 RGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISS 84
RG++++ D L+ LS + +L LSHN+L ++PP + +L + VLN N+++ LP ++S
Sbjct: 58 RGMTDIPDF--LWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSL 115
Query: 85 LQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDN 144
LQ LK L + MN L +P LEVL L++N LS+ LP F L+ LR L LS+N
Sbjct: 116 LQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQ--LPACFADLSRLRKLNLSNN 173
Query: 145 DFEILP-----------------------PDIGKLTKLQILSLRDNDLISLPKEIGELTQ 181
F +P I L LQI N++ S P+ + +T
Sbjct: 174 FFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTS 233
Query: 182 LKELHIQGNRLTVLPPELG------NLDLTGQKQVFKAENNPWVTPIADQFQLGVSHVFE 235
L+ L++ N + LP EL + + +NP P+ + + G+ +F
Sbjct: 234 LELLNLNNNDIQTLPSELHLLCRLVRIAWNPMDKGLHISHNPLSKPLPELVEGGLEMLFG 293
Query: 236 YIRSETY 242
Y++ + +
Sbjct: 294 YLKDKKH 300
Score = 75.5 bits (184), Expect = 5e-14
Identities = 55/176 (31%), Positives = 84/176 (47%), Gaps = 5/176 (2%)
Query: 41 HITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNT 100
H L +T +P + L ++ LN +NQ+ LP ++ L ++ LNL NRL +
Sbjct: 49 HHVSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKS 108
Query: 101 LPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQ 160
LPR L L+VL + N L+E +P L L LS N LP L++L+
Sbjct: 109 LPREVSLLQCLKVLFVNMNCLTE--VPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLR 166
Query: 161 ILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENN 216
L+L +N +P + L +L LH+ NRL + + +L Q+F AE N
Sbjct: 167 KLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHL---ASLQIFIAEGN 219
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 97.8 bits (242), Expect = 9e-21
Identities = 63/178 (35%), Positives = 97/178 (54%), Gaps = 9/178 (5%)
Query: 31 LDVNGLFTLSHITQLV-------LSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQIS 83
L NGL +L QL+ +SHN ++ +P I++L N+ L F+NN IE P+ +
Sbjct: 195 LQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLE 254
Query: 84 SLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSD 143
L L+ L+LG N+L +P SL L VL+L YN L+ + P +L L +L L+
Sbjct: 255 CLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLT--TFPKALCFLPKLISLDLTG 312
Query: 144 NDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGN 201
N LP +I +L L+ L + N L L EI +L ++KEL + N+L V+ ++ N
Sbjct: 313 NLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIEN 370
Score = 89.0 bits (219), Expect = 4e-18
Identities = 56/167 (33%), Positives = 87/167 (52%), Gaps = 5/167 (2%)
Query: 36 LFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGM 95
L TL ++ L LS N+L + +I LK ++ LNF +NQ P ++ LQ L+ LN+
Sbjct: 575 LCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQ 634
Query: 96 ---NRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPD 152
+L LP ++ L+ LD++ N + E +P N L L +L+ +N LPP
Sbjct: 635 IKGRKLTRLPGELSNMTQLKELDISNNAIRE--IPRNIGELRNLVSLHAYNNQISYLPPS 692
Query: 153 IGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPEL 199
+ L LQ L+L N+L +LP I + LKE++ N L P E+
Sbjct: 693 LLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEI 739
Score = 84.3 bits (207), Expect = 1e-16
Identities = 55/164 (33%), Positives = 85/164 (51%), Gaps = 5/164 (3%)
Query: 42 ITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTL 101
+ L LS NKL + + L NL+ L+ NQI+++P IS++ L L L N+ T
Sbjct: 512 LLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETF 571
Query: 102 PRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQ- 160
PR +L L+VLDL+ N L + + + L ++ L S N F P ++ +L L+
Sbjct: 572 PRELCTLENLQVLDLSENQLQK--ISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQ 629
Query: 161 --ILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 202
I ++ L LP E+ +TQLKEL I N + +P +G L
Sbjct: 630 LNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGEL 673
Score = 84.3 bits (207), Expect = 1e-16
Identities = 54/177 (30%), Positives = 92/177 (51%), Gaps = 10/177 (5%)
Query: 27 ISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQ 86
ISNM+ + H+ L+L NK P + L+NL+VL+ NQ++++ + I +L+
Sbjct: 552 ISNMISL-------HV--LILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLK 602
Query: 87 KLKHLNLGMNRLNTLPRGFGSLPALEVLDLTY-NNLSENSLPGNFFYLTTLRALYLSDND 145
++ LN N+ P L +LE L+++ LPG +T L+ L +S+N
Sbjct: 603 GIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNA 662
Query: 146 FEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 202
+P +IG+L L L +N + LP + L L++L++ GN LT LP + N+
Sbjct: 663 IREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNI 719
Score = 81.3 bits (199), Expect = 9e-16
Identities = 53/169 (31%), Positives = 83/169 (49%), Gaps = 2/169 (1%)
Query: 42 ITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTL 101
I ++ LS+NK+ P + L +L L+ N I E+P IS ++L HL L N+L
Sbjct: 466 IIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIF 525
Query: 102 PRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQI 161
F SL L+ LDL N + + +P + + +L L L N FE P ++ L LQ+
Sbjct: 526 SEHFCSLINLKYLDLGKNQIKK--IPASISNMISLHVLILCCNKFETFPRELCTLENLQV 583
Query: 162 LSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQV 210
L L +N L + +I L +++L+ N+ P EL L Q +
Sbjct: 584 LDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNI 632
Score = 76.6 bits (187), Expect = 2e-14
Identities = 55/197 (27%), Positives = 93/197 (47%), Gaps = 10/197 (5%)
Query: 14 EKNQPEVDMSDRGISNMLDVNGL-------FTLSHITQLVLSHNKL-TMVPPNIAELKNL 65
E+NQ ++ + + L+ GL + ++ L L N++ T + +L L
Sbjct: 131 EENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGL 190
Query: 66 EVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENS 125
E+L+ N + LP++I L L+ LN+ N ++ +P+ L + L YNN EN
Sbjct: 191 EILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQL-FFYNNYIEN- 248
Query: 126 LPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKEL 185
P + L L L L N +P + L L++L+L N L + PK + L +L L
Sbjct: 249 FPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISL 308
Query: 186 HIQGNRLTVLPPELGNL 202
+ GN ++ LP E+ L
Sbjct: 309 DLTGNLISSLPKEIREL 325
Score = 75.9 bits (185), Expect = 4e-14
Identities = 52/163 (31%), Positives = 78/163 (47%), Gaps = 2/163 (1%)
Query: 39 LSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 98
L + L L+ N ++ +P I ELKNLE L +N++ L +I L K+K L L N+L
Sbjct: 302 LPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKL 361
Query: 99 NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 158
+ + L +L L N L ++P L L LSDN LP I KL
Sbjct: 362 EVISHKIENFRELRILILDKNLL--KNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNN 419
Query: 159 LQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGN 201
L+ L + N+++ + I L + L GN +T +P E+ N
Sbjct: 420 LRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKN 462
Score = 67.4 bits (163), Expect = 1e-11
Identities = 45/165 (27%), Positives = 80/165 (48%), Gaps = 2/165 (1%)
Query: 39 LSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 98
L ++ L++ HNKLT + I +L ++ L +N++E + +I + ++L+ L L N L
Sbjct: 325 LKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLL 384
Query: 99 NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 158
+P LE L L+ N L+E LP L LR L+++ N+ + I L
Sbjct: 385 KNIPEKISCCAMLECLSLSDNKLTE--LPKYIHKLNNLRKLHVNRNNMVKITDCISHLNN 442
Query: 159 LQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLD 203
+ L N + +P EI ++ ++ + N++ P L LD
Sbjct: 443 ICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALD 487
Score = 66.6 bits (161), Expect = 2e-11
Identities = 55/210 (26%), Positives = 95/210 (45%), Gaps = 8/210 (3%)
Query: 5 LKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKN 64
+ L +E RE E + D L V +F L I +L L+ NKL ++ I +
Sbjct: 315 ISSLPKEIRELKNLETLLMDHNKLTFLAVE-IFQLLKIKELQLADNKLEVISHKIENFRE 373
Query: 65 LEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSEN 124
L +L N ++ +P +IS L+ L+L N+L LP+ L L L + NN+ +
Sbjct: 374 LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVK- 432
Query: 125 SLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKE 184
+ +L + +L S N +P +I K+ + L N ++ P + L L
Sbjct: 433 -ITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYY 491
Query: 185 LHIQGNRLTVLPPELGNLDLTGQKQVFKAE 214
L + GN ++ +P +D++ KQ+ E
Sbjct: 492 LSVNGNYISEIP-----VDISFSKQLLHLE 516
Score = 56.2 bits (134), Expect = 3e-08
Identities = 40/131 (30%), Positives = 68/131 (51%), Gaps = 5/131 (3%)
Query: 36 LFTLSHITQLVLSH---NKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLN 92
L L + QL +S KLT +P ++ + L+ L+ NN I E+P I L+ L L+
Sbjct: 621 LCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLH 680
Query: 93 LGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPD 152
N+++ LP SL L+ L+L+ NNL+ +LP + + +L+ + DN P +
Sbjct: 681 AYNNQISYLPPSLLSLNDLQQLNLSGNNLT--ALPSAIYNIFSLKEINFDDNPLLRPPVE 738
Query: 153 IGKLTKLQILS 163
I K +L ++
Sbjct: 739 ICKGKQLYTIA 749
Score = 47.4 bits (111), Expect = 1e-05
Identities = 39/138 (28%), Positives = 66/138 (47%), Gaps = 19/138 (13%)
Query: 67 VLNFFNNQ-IEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENS 125
++NF +++ + E+ Q+S + K L LG + ++L L E
Sbjct: 113 LVNFLSHETVGEVSPQVSE-ENQKQLGLGADNFT--------------VNLEAKGLQE-- 155
Query: 126 LPGNFFYLTTLRALYLSDNDFEILP-PDIGKLTKLQILSLRDNDLISLPKEIGELTQLKE 184
P + + ++ LYL N + D G L L+ILSL++N L SLP EI L L+
Sbjct: 156 FPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRI 215
Query: 185 LHIQGNRLTVLPPELGNL 202
L++ N ++ +P E+ L
Sbjct: 216 LNVSHNHISHIPKEISQL 233
>gi|30181233 leucine-rich repeats and calponin homology (CH) domain
containing 4 [Homo sapiens]
Length = 683
Score = 97.8 bits (242), Expect = 9e-21
Identities = 70/223 (31%), Positives = 105/223 (47%), Gaps = 45/223 (20%)
Query: 37 FTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMN 96
+ LS ITQ LS N+ VP +L +LE L+ ++N + L + +L L +LNL N
Sbjct: 65 YDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRN 124
Query: 97 RLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKL 156
+L+ LP LP LR L +S+N LPPDIG L
Sbjct: 125 QLSLLPPYICQLP--------------------------LRVLIVSNNKLGALPPDIGTL 158
Query: 157 TKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLT----------- 205
L+ L + N+L SLP E+ L+ L++L+++ N+L+ LP ELG+L L
Sbjct: 159 GSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLVRLDFSCNRVSR 218
Query: 206 --------GQKQVFKAENNPWVTPIADQFQLGVSHVFEYIRSE 240
QV ++NP +P A G H+F+Y+ +E
Sbjct: 219 IPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYLSTE 261
Score = 64.7 bits (156), Expect = 8e-11
Identities = 49/141 (34%), Positives = 74/141 (52%), Gaps = 4/141 (2%)
Query: 36 LFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGM 95
L L+ +T L LS N+L+++PP I +L L VL NN++ LP I +L L+ L++
Sbjct: 110 LGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQLDVSS 168
Query: 96 NRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGK 155
N L +LP L +L L++ N LS +LP L +R L S N +P +
Sbjct: 169 NELQSLPSELCGLSSLRDLNVRRNQLS--TLPEELGDLPLVR-LDFSCNRVSRIPVSFCR 225
Query: 156 LTKLQILSLRDNDLISLPKEI 176
L LQ++ L N L S P ++
Sbjct: 226 LRHLQVILLDSNPLQSPPAQV 246
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 97.1 bits (240), Expect = 2e-20
Identities = 71/221 (32%), Positives = 109/221 (49%), Gaps = 19/221 (8%)
Query: 4 SLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELK 63
+L+ L S ++ Q + S G+SN+ DV+ LS N LT VP + L
Sbjct: 199 ALQTLHLRSTQRTQSNLPTSLEGLSNLADVD------------LSCNDLTRVPECLYTLP 246
Query: 64 NLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSE 123
+L LN +NQI EL I ++ LNL N+L +LP L L+ L L N L
Sbjct: 247 SLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDF 306
Query: 124 NSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLK 183
+ LP LT L ++N+ E++P + + KL+ L L N L++LP+ I LT+++
Sbjct: 307 DGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIE 366
Query: 184 ELHIQGNRLTVLPP-------ELGNLDLTGQKQVFKAENNP 217
L ++ N V+PP E N+D + Q Q+ A +P
Sbjct: 367 VLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASP 407
Score = 78.2 bits (191), Expect = 7e-15
Identities = 46/148 (31%), Positives = 76/148 (51%), Gaps = 1/148 (0%)
Query: 56 PPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLD 115
P N+ + +L L + LP ++++LQKL+HL++ N L TL SLP+L +
Sbjct: 26 PENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIV 85
Query: 116 LTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKE 175
N+L + +P + F L L L LS N P ++ + +L+L N + ++P +
Sbjct: 86 ARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQ 145
Query: 176 IG-ELTQLKELHIQGNRLTVLPPELGNL 202
+ LT L L + NRL LPP++ L
Sbjct: 146 LFINLTDLLYLDLSENRLESLPPQMRRL 173
Score = 77.8 bits (190), Expect = 1e-14
Identities = 67/236 (28%), Positives = 106/236 (44%), Gaps = 52/236 (22%)
Query: 36 LFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQI-SSLQKLKHLNLG 94
+F L ++ L LSHN+LT P + KN+ VLN +N I+ +P Q+ +L L +L+L
Sbjct: 100 IFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLS 159
Query: 95 MNRLNTLP------------------------RGFGSLPALEVLDLTYNNLSENSLPGN- 129
NRL +LP R ++ AL+ L L ++++LP +
Sbjct: 160 ENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSL 219
Query: 130 ----------------------FFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDN 167
+ L +LR L LS N L I + ++ L+L N
Sbjct: 220 EGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRN 279
Query: 168 DLISLPKEIGELTQLKELHIQGNRLTV--LPPELGNLDLTGQKQVFKAENNPWVTP 221
L SLP I +L++LK+L++ N+L LP +G LT ++ A NN + P
Sbjct: 280 QLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGK--LTNLEEFMAANNNLELVP 333
Score = 62.8 bits (151), Expect = 3e-10
Identities = 54/181 (29%), Positives = 88/181 (48%), Gaps = 30/181 (16%)
Query: 28 SNMLDVNG-LFTLSHITQLVLSHNKL--TMVPPNIAELKNLEVLNFFNNQIEELPTQISS 84
+N+ ++G L +L + +V N L + VP +I +L +L VL+ +NQ+ E P ++ +
Sbjct: 66 NNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELEN 125
Query: 85 LQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDN 144
+ + LNL N ++T+P N L F LT L L LS+N
Sbjct: 126 AKNMLVLNLSHNSIDTIP----------------NQL--------FINLTDLLYLDLSEN 161
Query: 145 DFEILPPDIGKLTKLQILSLRDNDLISLP-KEIGELTQLKELHIQGNRLTV--LPPELGN 201
E LPP + +L LQ L L N L+ +++ +T L+ LH++ + T LP L
Sbjct: 162 RLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEG 221
Query: 202 L 202
L
Sbjct: 222 L 222
Score = 46.6 bits (109), Expect = 2e-05
Identities = 31/100 (31%), Positives = 52/100 (52%), Gaps = 2/100 (2%)
Query: 106 GSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLR 165
G LP + +DL+ N+ P N +T+LR L L+ LP ++ L KL+ LS+
Sbjct: 5 GVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVS 64
Query: 166 DNDLISLPKEIGELTQLKELHIQGNRL--TVLPPELGNLD 203
N+L +L E+ L L+ + + N L + +P ++ LD
Sbjct: 65 HNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLD 104
>gi|40217803 leucine rich repeat containing 8 family, member E [Homo
sapiens]
Length = 796
Score = 96.3 bits (238), Expect = 3e-20
Identities = 61/170 (35%), Positives = 89/170 (52%), Gaps = 4/170 (2%)
Query: 34 NGLFTLSHITQLVLSHNKLTMVPPNIA--ELKNLEVLNFFNNQIEELPTQISSLQKLKHL 91
+ +F+L + +L L N L + ++ + L L ++NQI +P + L+ L+ L
Sbjct: 599 HAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQL 658
Query: 92 NLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPP 151
L N+L TLP G L +LD+++N L +SLP L L+ L LS N E LP
Sbjct: 659 YLSYNKLETLPSQLGLCSGLRLLDVSHNGL--HSLPPEVGLLQNLQHLALSYNALEALPE 716
Query: 152 DIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGN 201
++ KL+ L L DN L L +G L L L ++GNRL LP ELGN
Sbjct: 717 ELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGN 766
Score = 93.6 bits (231), Expect = 2e-19
Identities = 60/183 (32%), Positives = 97/183 (53%), Gaps = 4/183 (2%)
Query: 19 EVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEEL 78
E+D+ D + ++ ++ + L L HN++ VP ++ +L++LE L N++E L
Sbjct: 609 ELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETL 668
Query: 79 PTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRA 138
P+Q+ L+ L++ N L++LP G L L+ L L+YN L +LP F+ LR
Sbjct: 669 PSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNAL--EALPEELFFCRKLRT 726
Query: 139 LYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKE--LHIQGNRLTVLP 196
L L DN L P +G L L L L+ N L +LP+E+G LK+ L ++ LP
Sbjct: 727 LLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDTLYQGLP 786
Query: 197 PEL 199
E+
Sbjct: 787 AEV 789
Score = 56.2 bits (134), Expect = 3e-08
Identities = 46/150 (30%), Positives = 72/150 (48%), Gaps = 2/150 (1%)
Query: 55 VPPNIAELK-NLEVLNFFNNQIEELP-TQISSLQKLKHLNLGMNRLNTLPRGFGSLPALE 112
VP ++ ++ +L+ L+ N+ + + L L+ L L L +P SL AL+
Sbjct: 549 VPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGALQ 608
Query: 113 VLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISL 172
LDL N+L +F + L L L N +P + KL L+ L L N L +L
Sbjct: 609 ELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETL 668
Query: 173 PKEIGELTQLKELHIQGNRLTVLPPELGNL 202
P ++G + L+ L + N L LPPE+G L
Sbjct: 669 PSQLGLCSGLRLLDVSHNGLHSLPPEVGLL 698
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 95.9 bits (237), Expect = 3e-20
Identities = 60/165 (36%), Positives = 89/165 (53%), Gaps = 2/165 (1%)
Query: 35 GLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLG 94
GL L+H+ L LS N L +P + +++ L L +N + ELP + +L L L +
Sbjct: 120 GLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVT 179
Query: 95 MNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIG 154
NRL TLP G+L L+ LDL+ N L ++LP L +L L L+ N + LP +
Sbjct: 180 HNRLQTLPPALGALSTLQRLDLSQNLL--DTLPPEIGGLGSLLELNLASNRLQSLPASLA 237
Query: 155 KLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPEL 199
L L++L L N L S+P ++ L L L ++ N+L LPPEL
Sbjct: 238 GLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 87.0 bits (214), Expect = 2e-17
Identities = 58/153 (37%), Positives = 82/153 (53%), Gaps = 2/153 (1%)
Query: 52 LTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPAL 111
LT +P ++ L +L L+ N +E LP + ++ L L L N L+ LP G+LPAL
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 112 EVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLIS 171
L +T+N L +LP L+TL+ L LS N + LPP+IG L L L+L N L S
Sbjct: 174 TFLTVTHNRLQ--TLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQS 231
Query: 172 LPKEIGELTQLKELHIQGNRLTVLPPELGNLDL 204
LP + L L+ L + N L +P +L L L
Sbjct: 232 LPASLAGLRSLRLLVLHSNLLASVPADLARLPL 264
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 95.9 bits (237), Expect = 3e-20
Identities = 60/165 (36%), Positives = 89/165 (53%), Gaps = 2/165 (1%)
Query: 35 GLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLG 94
GL L+H+ L LS N L +P + +++ L L +N + ELP + +L L L +
Sbjct: 120 GLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVT 179
Query: 95 MNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIG 154
NRL TLP G+L L+ LDL+ N L ++LP L +L L L+ N + LP +
Sbjct: 180 HNRLQTLPPALGALSTLQRLDLSQNLL--DTLPPEIGGLGSLLELNLASNRLQSLPASLA 237
Query: 155 KLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPEL 199
L L++L L N L S+P ++ L L L ++ N+L LPPEL
Sbjct: 238 GLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 87.0 bits (214), Expect = 2e-17
Identities = 58/153 (37%), Positives = 82/153 (53%), Gaps = 2/153 (1%)
Query: 52 LTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPAL 111
LT +P ++ L +L L+ N +E LP + ++ L L L N L+ LP G+LPAL
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 112 EVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLIS 171
L +T+N L +LP L+TL+ L LS N + LPP+IG L L L+L N L S
Sbjct: 174 TFLTVTHNRLQ--TLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQS 231
Query: 172 LPKEIGELTQLKELHIQGNRLTVLPPELGNLDL 204
LP + L L+ L + N L +P +L L L
Sbjct: 232 LPASLAGLRSLRLLVLHSNLLASVPADLARLPL 264
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 95.9 bits (237), Expect = 3e-20
Identities = 58/158 (36%), Positives = 88/158 (55%), Gaps = 2/158 (1%)
Query: 39 LSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 98
L + L +S N++ V +I+ + LE L +N +++LP I L+KL L + N+L
Sbjct: 229 LKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQL 288
Query: 99 NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 158
LP G+L LE D + N L SLP YL +LR L + +N LP +IG
Sbjct: 289 TMLPNTIGNLSLLEEFDCSCNELE--SLPSTIGYLHSLRTLAVDENFLPELPREIGSCKN 346
Query: 159 LQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLP 196
+ ++SLR N L LP+EIG++ +L+ L++ NRL LP
Sbjct: 347 VTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLP 384
Score = 94.7 bits (234), Expect = 8e-20
Identities = 65/183 (35%), Positives = 90/183 (49%), Gaps = 22/183 (12%)
Query: 42 ITQLVLSHNKLTMVPPNIAEL-KNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNT 100
I+ L SH L VP + + LE L NQIEELP Q+ + Q L+ L++ N L+
Sbjct: 24 ISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSN 83
Query: 101 LPRGFGSLPALEVLDLTYNNLSE---------------------NSLPGNFFYLTTLRAL 139
LP SL L+ LD++ N + E + LP F L L L
Sbjct: 84 LPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQL 143
Query: 140 YLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPEL 199
YL+D E LP + G+L KL+IL LR+N L +LPK + +L QL+ L + N LP L
Sbjct: 144 YLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVL 203
Query: 200 GNL 202
+
Sbjct: 204 DQI 206
Score = 91.7 bits (226), Expect = 6e-19
Identities = 56/169 (33%), Positives = 87/169 (51%), Gaps = 2/169 (1%)
Query: 36 LFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGM 95
LF + +L + N L+ +P IA L NL+ L+ N ++E P I + L + +
Sbjct: 65 LFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASV 124
Query: 96 NRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGK 155
N ++ LP GF L L + L N+ LP NF L LR L L +N + LP + K
Sbjct: 125 NPISKLPDGFTQL--LNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHK 182
Query: 156 LTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDL 204
L +L+ L L +N+ LP+ + ++ L+EL + N L VLP +G L +
Sbjct: 183 LAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKM 231
Score = 89.0 bits (219), Expect = 4e-18
Identities = 62/202 (30%), Positives = 101/202 (50%), Gaps = 10/202 (4%)
Query: 1 MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIA 60
+ KS+ KL + R +D+ + + +V L + ++ +L + +N L ++P +I
Sbjct: 176 LPKSMHKLAQLER------LDLGNNEFGELPEV--LDQIQNLRELWMDNNALQVLPGSIG 227
Query: 61 ELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNN 120
+LK L L+ N+IE + IS + L+ L L N L LP G L L L + N
Sbjct: 228 KLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQ 287
Query: 121 LSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT 180
L+ LP L+ L S N+ E LP IG L L+ L++ +N L LP+EIG
Sbjct: 288 LT--MLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCK 345
Query: 181 QLKELHIQGNRLTVLPPELGNL 202
+ + ++ N+L LP E+G +
Sbjct: 346 NVTVMSLRSNKLEFLPEEIGQM 367
Score = 86.3 bits (212), Expect = 3e-17
Identities = 63/185 (34%), Positives = 88/185 (47%), Gaps = 4/185 (2%)
Query: 20 VDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELP 79
++ S IS + D G L ++TQL L+ L +P N L L +L N ++ LP
Sbjct: 120 IEASVNPISKLPD--GFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLP 177
Query: 80 TQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRAL 139
+ L +L+ L+LG N LP + L L + N L LPG+ L L L
Sbjct: 178 KSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQV--LPGSIGKLKMLVYL 235
Query: 140 YLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPEL 199
+S N E + DI L+ L L N L LP IG L +L L + N+LT+LP +
Sbjct: 236 DMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTI 295
Query: 200 GNLDL 204
GNL L
Sbjct: 296 GNLSL 300
Score = 86.3 bits (212), Expect = 3e-17
Identities = 60/179 (33%), Positives = 89/179 (49%), Gaps = 6/179 (3%)
Query: 20 VDMSDRGISNM-LDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEEL 78
+DMS I + +D++G L L+LS N L +P +I LK L L +NQ+ L
Sbjct: 235 LDMSKNRIETVDMDISGCEALE---DLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTML 291
Query: 79 PTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRA 138
P I +L L+ + N L +LP G L +L L + N L E LP +
Sbjct: 292 PNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPE--LPREIGSCKNVTV 349
Query: 139 LYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPP 197
+ L N E LP +IG++ KL++L+L DN L +LP +L +L L + N+ L P
Sbjct: 350 MSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIP 408
>gi|19923729 leucine rich repeat containing 8 family, member C [Homo
sapiens]
Length = 803
Score = 95.1 bits (235), Expect = 6e-20
Identities = 51/165 (30%), Positives = 89/165 (53%), Gaps = 2/165 (1%)
Query: 19 EVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEEL 78
E+D+ + + ++ ++ L +T L L HN +T +P +I +L +LE L+F +N+IE L
Sbjct: 616 ELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVL 675
Query: 79 PTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRA 138
P+ + K+++L+L N + +P G L +L+ +T N + SLP ++ L+
Sbjct: 676 PSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKV--ESLPDELYFCKKLKT 733
Query: 139 LYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLK 183
L + N +L P IG L L L ++ N LP E+G+ LK
Sbjct: 734 LKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALK 778
Score = 92.8 bits (229), Expect = 3e-19
Identities = 69/212 (32%), Positives = 108/212 (50%), Gaps = 14/212 (6%)
Query: 3 KSLKKLVEESREKNQPE--VDMSDR--------GISNMLDVNGLFTLSHITQLVLSHNKL 52
KSLK L +S P+ VD+S + ++ +N L ++++T+L L H L
Sbjct: 542 KSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDL 601
Query: 53 TMVPPNIAELKNLEVLNFFNNQIEELPTQIS--SLQKLKHLNLGMNRLNTLPRGFGSLPA 110
+P + L +L+ L+ N ++ + +S L+KL L L N + +P L +
Sbjct: 602 ERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTS 661
Query: 111 LEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLI 170
LE L ++N + LP + F +R L LS ND +PP+IG L LQ S+ N +
Sbjct: 662 LERLSFSHNKIEV--LPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVE 719
Query: 171 SLPKEIGELTQLKELHIQGNRLTVLPPELGNL 202
SLP E+ +LK L I N L+VL P++GNL
Sbjct: 720 SLPDELYFCKKLKTLKIGKNSLSVLSPKIGNL 751
Score = 40.0 bits (92), Expect = 0.002
Identities = 52/229 (22%), Positives = 100/229 (43%), Gaps = 15/229 (6%)
Query: 36 LFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSL-QKLKHLNLG 94
+F ++ + L L K M+P IA+L NL+ L+ ++ +S L + LK L++
Sbjct: 440 VFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVK 499
Query: 95 MNRLNTLP---RGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPP 151
+ + LP G +L L ++ +++S N + L +L+ L + N +I
Sbjct: 500 FDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSNVSKIPQA 559
Query: 152 DIGKLTKLQILSL-RDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQV 210
+ + LQ + + D + + + ++T L EL + L +P + +L L+ Q+
Sbjct: 560 VVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSL-LSLQELD 618
Query: 211 FKAENNPWVTPIADQFQLGVSHVFEYIRSETYKYLYGRHMQANPEPPKK 259
K N + I F+++R T L+ + PE KK
Sbjct: 619 LKENNLKSIEEIVS---------FQHLRKLTVLKLWHNSITYIPEHIKK 658
Score = 28.9 bits (63), Expect = 5.2
Identities = 35/115 (30%), Positives = 49/115 (42%), Gaps = 3/115 (2%)
Query: 84 SLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSD 143
S KLK LNL R A L+L LS LP F +T L++L L
Sbjct: 396 SENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLS--GLPDTVFEITELQSLKLEI 453
Query: 144 NDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQ-LKELHIQGNRLTVLPP 197
++P I +L LQ LSL + + L + LK L ++ + + LPP
Sbjct: 454 IKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPP 508
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.135 0.379
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,381,307
Number of Sequences: 37866
Number of extensions: 441041
Number of successful extensions: 2697
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 124
Number of HSP's successfully gapped in prelim test: 149
Number of HSP's that attempted gapping in prelim test: 1091
Number of HSP's gapped (non-prelim): 790
length of query: 277
length of database: 18,247,518
effective HSP length: 101
effective length of query: 176
effective length of database: 14,423,052
effective search space: 2538457152
effective search space used: 2538457152
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.