Search of human proteins with 68131557

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
         (1053 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                  2114   0.0  
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                  1270   0.0  
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                 1251   0.0  
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        333   4e-91
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       327   3e-89
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        327   3e-89
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        327   3e-89
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       327   3e-89
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        327   3e-89
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        327   3e-89
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        327   3e-89
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        327   3e-89
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   285   2e-76
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...   272   1e-72
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   246   8e-65
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   243   5e-64
gi|34304381 inversin isoform a [Homo sapiens]                         197   3e-50
gi|34304379 inversin isoform b [Homo sapiens]                         197   3e-50
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   194   5e-49
gi|116534990 ankyrin-like protein 1 [Homo sapiens]                    182   1e-45
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    182   1e-45
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ...   169   1e-41
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ...   169   1e-41
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...   168   3e-41
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                    168   3e-41
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi...   165   2e-40
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ...   164   3e-40
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]          164   4e-40
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]        164   4e-40
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...   164   4e-40

>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score = 2114 bits (5478), Expect = 0.0
 Identities = 1053/1053 (100%), Positives = 1053/1053 (100%)

Query: 1    MAFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELL 60
            MAFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELL
Sbjct: 1    MAFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELL 60

Query: 61   ILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAV 120
            ILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAV
Sbjct: 61   ILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAV 120

Query: 121  KCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWA 180
            KCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWA
Sbjct: 121  KCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWA 180

Query: 181  AYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGN 240
            AYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGN
Sbjct: 181  AYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGN 240

Query: 241  TPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVN 300
            TPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVN
Sbjct: 241  TPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVN 300

Query: 301  MKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLIT 360
            MKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLIT
Sbjct: 301  MKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLIT 360

Query: 361  SGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLEC 420
            SGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLEC
Sbjct: 361  SGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLEC 420

Query: 421  LNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAAT 480
            LNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAAT
Sbjct: 421  LNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAAT 480

Query: 481  SDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTD 540
            SDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTD
Sbjct: 481  SDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTD 540

Query: 541  MLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVD 600
            MLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVD
Sbjct: 541  MLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVD 600

Query: 601  VLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLS 660
            VLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLS
Sbjct: 601  VLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLS 660

Query: 661  VLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR 720
            VLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR
Sbjct: 661  VLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR 720

Query: 721  TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV 780
            TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV
Sbjct: 721  TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV 780

Query: 781  FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQ 840
            FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQ
Sbjct: 781  FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQ 840

Query: 841  LLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSK 900
            LLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSK
Sbjct: 841  LLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSK 900

Query: 901  GHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGY 960
            GHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGY
Sbjct: 901  GHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGY 960

Query: 961  TPALACAPNKDVADCLALILATMMPVSSSSPLSSLTFNAINRYTNTSKTVSFEALPIMRN 1020
            TPALACAPNKDVADCLALILATMMPVSSSSPLSSLTFNAINRYTNTSKTVSFEALPIMRN
Sbjct: 961  TPALACAPNKDVADCLALILATMMPVSSSSPLSSLTFNAINRYTNTSKTVSFEALPIMRN 1020

Query: 1021 EPSSYCSFNNIGGEQEYLYTDVDELNDSDSETY 1053
            EPSSYCSFNNIGGEQEYLYTDVDELNDSDSETY
Sbjct: 1021 EPSSYCSFNNIGGEQEYLYTDVDELNDSDSETY 1053


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score = 1270 bits (3287), Expect = 0.0
 Identities = 635/929 (68%), Positives = 740/929 (79%), Gaps = 38/929 (4%)

Query: 27  LIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCS 86
           LI K EDVN  D+EKRTPLH AA+LGDAEIIELLILSGARVNAKD+ WLTPLHRAVAS S
Sbjct: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61

Query: 87  EEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHH 146
           EEAVQVL+KHSADVNARDKNWQTPLH+AAANKAVKCAE ++PLLS+VNVSDR GRTALHH
Sbjct: 62  EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHH 121

Query: 147 AAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS 206
           AA +GH EMV LLL++GANINAFDKKDRRA+HWAAYMGH++VV LL++HGAEVTCKDKK 
Sbjct: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKG 181

Query: 207 YTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVN 266
           YTPLHAAAS+G I+VVK+LL+LGV+++E N YGNT LH+ACYNGQD VVNELID GA VN
Sbjct: 182 YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVN 241

Query: 267 QKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTII 326
           Q N  GFTPLHFAAASTHGALCLELLV NGADVN++SKDGK+PLHMTA+HGRF+RSQT+I
Sbjct: 242 QPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLI 301

Query: 327 QSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSD 386
           Q+G  IDC DK+GNTPLH+AARYGHELLINTL TSGADTAK GIH MFPLHLAAL+  SD
Sbjct: 302 QNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSD 361

Query: 387 CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446
           CCRKLLSSGF+IDTPD FGRTCLHAAAAGGN+EC+ LL ++GADF+KKDK GR+PLHYAA
Sbjct: 362 CCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAA 421

Query: 447 ANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGK-------------------- 486
           ANC++ C+  LV +GA+VN+ D+ G T LHYAA SD D                      
Sbjct: 422 ANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERAREL 481

Query: 487 -------CLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGT 539
                  CLE+LL+NDANP IRDK+GYN++HY+AAYGHR CL+L+   T        SG 
Sbjct: 482 KEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERT-------NSG- 533

Query: 540 DMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECV 599
               +SD+ AT SPLHLAAY+GHHQALEVL+QSL+DLD+R+  GRT LDLAAFKGH ECV
Sbjct: 534 --FEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECV 591

Query: 600 DVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLML 659
           + LIN GASI VKD + KRTP+HA+  NGH+ CLRLL+  A+   AVD++D  GQTPLML
Sbjct: 592 EALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLML 651

Query: 660 SVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRG 719
           +V  GH D V  LL K ANVD  D  G TALHRG +TGHEECV  LL+     L +DSRG
Sbjct: 652 AVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRG 711

Query: 720 RTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQE 779
           RTP+H +AA GH   L  LLQ A S + +    DN GYT LHWACYNG+E C+E+LLEQ+
Sbjct: 712 RTPLHYAAARGHATWLSELLQMALS-EEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQK 770

Query: 780 VFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECL 839
            F+K  GN F+PLHCA+IND+   A +L+  + +SIV+  D KGRTPL AAAF DHVECL
Sbjct: 771 CFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECL 830

Query: 840 QLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACS 899
           QLLL H+A VN+VD++GKT LMMAAENGQ   V++LV+SA A+LT++D   NT LHLACS
Sbjct: 831 QLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACS 890

Query: 900 KGHETSALLILEKITDRNLINATNAALQT 928
           KGHE  ALLIL+KI D +LIN  N ALQT
Sbjct: 891 KGHEKCALLILDKIQDESLINEKNNALQT 919



 Score =  337 bits (865), Expect = 3e-92
 Identities = 260/826 (31%), Positives = 395/826 (47%), Gaps = 35/826 (4%)

Query: 11  SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
           +L  A  NG  + V  L+ K  ++N  D + R  LH AAY+G  +++ LLI  GA V  K
Sbjct: 118 ALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK 177

Query: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
           D K  TPLH A ++     V+ LL    +++  +    T LHIA  N        L+   
Sbjct: 178 DKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYG 237

Query: 131 SNVNVSDRAGRTALHHAAFSGHGEM-VKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVV 189
           +NVN  +  G T LH AA S HG + ++LL++ GA++N   K  +  +H  A  G     
Sbjct: 238 ANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRS 297

Query: 190 KLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYN 249
           + L+ +G E+ C DK   TPLH AA  G   ++  L   G D  +   +   PLH+A  N
Sbjct: 298 QTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALN 357

Query: 250 GQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTP 309
                  +L+  G  ++  ++ G T LH AAA+     C++LL  +GAD + K K G+TP
Sbjct: 358 AHSDCCRKLLSSGFEIDTPDKFGRTCLH-AAAAGGNVECIKLLQSSGADFHKKDKCGRTP 416

Query: 310 LHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRG 369
           LH  A +  F   +T++ +GA ++  D  G T LH AA    ++  N  I   A      
Sbjct: 417 LHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAA--ASDMDRNKTILGNAHDNSEE 474

Query: 370 IHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLL-NTG 428
           +     L        + C   LL +  +    D  G   +H AAA G+ +CL LLL  T 
Sbjct: 475 LERARELKEKEA---TLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTN 531

Query: 429 ADFNKKDKFG-RSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKC 487
           + F + D    +SPLH AA N ++Q L  L+ S   ++  DE+G T L  AA      +C
Sbjct: 532 SGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKG-HTEC 590

Query: 488 LEYLLRNDANPGIRDK-QGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSD 546
           +E L+   A+  ++D       +H S   GH LCL+L         L+E +      D  
Sbjct: 591 VEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRL---------LLEIADNPEAVDVK 641

Query: 547 NRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQG 606
           +    +PL LA  +GH  A+ +L++   ++D  +  G T L      GH ECV +L+ Q 
Sbjct: 642 DAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQE 701

Query: 607 ASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHT 666
            SIL KD    RTP+H AA  GH+  L  L+  A  +     +D  G TPL  +  NG+ 
Sbjct: 702 VSILCKD-SRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNE 760

Query: 667 DCVYSLLNKGANVDAKDKWGR--TALHRGAVTGHEECVDALLQHGAKCLL--RDSRGRTP 722
           +C+  LL +      +   G   T LH   +  H  C   LL      ++  RD +GRTP
Sbjct: 761 NCIEVLLEQKC---FRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTP 817

Query: 723 IHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQ 782
           +  +A   H+  L  LL+ +A ++A     DN G TAL  A  NG    V++L+      
Sbjct: 818 LRAAAFADHVECLQLLLRHSAPVNA----VDNSGKTALMMAAENGQAGAVDILVNSAQAD 873

Query: 783 KT--EGNAFSPLHCAVINDNEGAAEMLIDTL-GASIVNATDSKGRT 825
            T  + +  +PLH A    +E  A +++D +   S++N  ++  +T
Sbjct: 874 LTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKNNALQT 919



 Score =  319 bits (817), Expect = 1e-86
 Identities = 248/767 (32%), Positives = 356/767 (46%), Gaps = 62/767 (8%)

Query: 7   RDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGAR 66
           +D+ +L  A + G  D V  LI    +V  +D +  TPLHAAA  G   +++ L+  G  
Sbjct: 147 KDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVE 206

Query: 67  VNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAAN-KAVKCAEA 125
           ++  +    T LH A  +  +  V  L+ + A+VN  + N  TPLH AAA+     C E 
Sbjct: 207 IDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLEL 266

Query: 126 LVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGH 185
           LV   ++VN+  + G++ LH  A  G     + L+  G  I+  DK     +H AA  GH
Sbjct: 267 LVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGH 326

Query: 186 IEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245
             ++  L + GA+       S  PLH AA +      + LL  G +++ P+ +G T LH 
Sbjct: 327 ELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHA 386

Query: 246 ACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 305
           A   G    +  L   GA  ++K++ G TPLH+AAA+ H   C+E LV  GA+VN     
Sbjct: 387 AAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCH-FHCIETLVTTGANVNETDDW 445

Query: 306 GKTPLHMTALHGRFSRSQTI-----------------------------IQSGAVIDCED 336
           G+T LH  A      R++TI                             +Q+ A     D
Sbjct: 446 GRTALHYAAA-SDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRD 504

Query: 337 KNGNTPLHIAARYGHELLINTLI---TSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLS 393
           K G   +H AA YGH   +  L+    SG + +  G     PLHLAA +G       LL 
Sbjct: 505 KEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGA-TKSPLHLAAYNGHHQALEVLLQ 563

Query: 394 SGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKF-GRSPLHYAAANCNYQ 452
           S  D+D  D+ GRT L  AA  G+ EC+  L+N GA    KD    R+PLH +  N +  
Sbjct: 564 SLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTL 623

Query: 453 C---LFALVGSGASVNDLDERGCTPLHYA-ATSDTDGKCLEYLLRNDANPGIRDKQGYNA 508
           C   L  +  +  +V+  D +G TPL  A A    D   L  LL  +AN    D  G  A
Sbjct: 624 CLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSL--LLEKEANVDTVDILGCTA 681

Query: 509 VHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEV 568
           +H     GH  C+Q+         L+E   + +  DS  R   +PLH AA  GH   L  
Sbjct: 682 LHRGIMTGHEECVQM---------LLEQEVSILCKDSRGR---TPLHYAAARGHATWLSE 729

Query: 569 LVQSLL---DLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAA 625
           L+Q  L   D   +++ G TPL  A + G+  C++VL+ Q      K      TP+H A 
Sbjct: 730 LLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ--KCFRKFIGNPFTPLHCAI 787

Query: 626 TNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKW 685
            N H  C  LL+G A   + V  +D  G+TPL  +    H +C+  LL   A V+A D  
Sbjct: 788 INDHGNCASLLLG-AIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNS 846

Query: 686 GRTALHRGAVTGHEECVDALLQHG-AKCLLRDSRGRTPIHLSAACGH 731
           G+TAL   A  G    VD L+    A   ++D    TP+HL+ + GH
Sbjct: 847 GKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGH 893


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score = 1251 bits (3238), Expect = 0.0
 Identities = 632/1056 (59%), Positives = 785/1056 (74%), Gaps = 56/1056 (5%)

Query: 1    MAFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELL 60
            M  L + DQP LVQAIF+ D +EVR+L+ +KE++N  D E+RTPLHAAAY+GD  I++LL
Sbjct: 1    MGILSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLL 60

Query: 61   ILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAV 120
            ++SGA VNAKD+ WLTPLHRA AS +E+ + +LL HSADVNARDK WQTPLH+AAAN+A 
Sbjct: 61   LMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRAT 120

Query: 121  KCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWA 180
            KCAEAL PLLS++NV+DR+GR+ALHHA  SGH E V LLL++GA++N  DKK+R+ +HWA
Sbjct: 121  KCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWA 180

Query: 181  AYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGN 240
            A++GH+EV+KLLV+ GA++ CKD+K Y  LH AA+SG I VVKYLL +G +++EPNA+GN
Sbjct: 181  AFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGN 240

Query: 241  TPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVN 300
            T LH+ACY GQD V  EL++ GA VNQ N+KGFTPLH AA ST+GALCLELLV NGADVN
Sbjct: 241  TALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVN 300

Query: 301  MKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLIT 360
             +SK+GK+PLHM A+HGRF+RSQ +IQ+G+ IDC DK GNTPLH+AARYGHELLI+TL+T
Sbjct: 301  YQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMT 360

Query: 361  SGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSS------------------GFDIDTPD 402
            +GADTA+RGIH MFPLHLA L GFSDCCRKLLSS                  GFDI+TPD
Sbjct: 361  NGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPD 420

Query: 403  DFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGA 462
            + GRTCLHAAA+GGN+ECLNLLL++GAD  ++DKFGR+PLHYAAAN +YQC   LV +GA
Sbjct: 421  NLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGA 480

Query: 463  SVNDLDERGCTPLHYAATSDTDGK---------------------------CLEYLLRND 495
             VN+ D +GC+PLHYAA SDT  +                           CLE+LL N 
Sbjct: 481  GVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNG 540

Query: 496  ANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLH 555
            A+P +RD+QGY AVHY+AAYG+R  L+L         L+E S  + L D ++   +SPLH
Sbjct: 541  ADPSLRDRQGYTAVHYAAAYGNRQNLEL---------LLEMS-FNCLEDVESTIPVSPLH 590

Query: 556  LAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYI 615
            LAAY+GH +AL+ L ++L++LDVR+  GRT L LA  +G  ECV+VL   GAS L+K+  
Sbjct: 591  LAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERK 650

Query: 616  LKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNK 675
             K TP+HAAA +GH++ L LLI + E  +  D+ D  GQTPLML+++NGH DCV+ LL K
Sbjct: 651  RKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEK 710

Query: 676  GANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVL 735
            G+  DA D  GRTALHRGAVTG E+C+ ALL H A  L RD +GRTPIHL++ACGH  VL
Sbjct: 711  GSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVL 770

Query: 736  GALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCA 795
              LLQ+A S D   A  D  GY+ +HWA Y GHE C+ELLLE   F   EGN F+PLHCA
Sbjct: 771  RTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCA 830

Query: 796  VINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDST 855
            VIN+ +   EML+  LGA IVN+ D+KGRTPLHAAAF D+V  L++LL H A+VN+ D T
Sbjct: 831  VINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHT 890

Query: 856  GKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITD 915
            G+T LM AAENGQT  VE L+    A+LT+ D +KNTALHLACSKGHE  AL+IL +  D
Sbjct: 891  GRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQD 950

Query: 916  RNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADC 975
              LINATN+ALQ PLH+AARNGL  VVQ LL  GA+VLAVDE G+TPALACAPNKDVADC
Sbjct: 951  LGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADC 1010

Query: 976  LALILATMMPVSSSSPLSSLTFNAI-NRYTNTSKTV 1010
            LALIL+TM P      +S  +F+ + N     +KTV
Sbjct: 1011 LALILSTMKPFPPKDAVSPFSFSLLKNCSIAAAKTV 1046


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  333 bits (855), Expect = 4e-91
 Identities = 257/816 (31%), Positives = 374/816 (45%), Gaps = 66/816 (8%)

Query: 147 AAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS 206
           AA +GH E     +  G +IN  ++    A+H A+  GH+EVV  L+   A V    KK 
Sbjct: 48  AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107

Query: 207 YTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVN 266
            T LH A+ +G   VVK L+  G ++N  +  G TPL++A       VV  L+D GA  +
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQS 167

Query: 267 QKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTII 326
              E GFTPL  A    H  + + LL+ N    + K K     LH+ A       +  ++
Sbjct: 168 LATEDGFTPLAVALQQGHDQV-VSLLLEN----DTKGKVRLPALHIAARKDDTKAAALLL 222

Query: 327 QSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSD 386
           Q+    D E K+G TPLHIAA YG+  +   L+   A       + + PLH+A+  G ++
Sbjct: 223 QNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNAN 282

Query: 387 CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446
             + LL  G  ID     G T LH  A  G+ + + +LL+  A    K K G SPLH A 
Sbjct: 283 MVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMAT 342

Query: 447 ANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGY 506
              +  C+  L+     V+D+     T LH AA      K  + LL   ANP  +   G+
Sbjct: 343 QGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCG-HYKVAKVLLDKKANPNAKALNGF 401

Query: 507 NAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQAL 566
                                                        +PLH+A      + +
Sbjct: 402 ---------------------------------------------TPLHIACKKNRIKVM 416

Query: 567 EVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAAT 626
           E+L++    +     SG TP+ +AAF GHV  V  L++ GAS    + +   T +H AA 
Sbjct: 417 ELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTN-VRGETALHMAAR 475

Query: 627 NGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWG 686
           +G +E +R L+ +      V+ +  + QTPL +S   G  D V  LL +GA+ +A    G
Sbjct: 476 SGQAEVVRYLVQDGAQ---VEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSG 532

Query: 687 RTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMD 746
            T LH  A  GHE+    LL HGA   +   +G TP+H++A  G + V   LLQ +AS D
Sbjct: 533 YTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPD 592

Query: 747 ANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEG-NAFSPLHCAVINDNEGAAE 805
           A    A   G T LH A +  ++    LLL+Q         N ++PLH A   +    A 
Sbjct: 593 A----AGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIAT 648

Query: 806 MLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAE 865
            L++  GA   NA   +G   +H AA   HV+ + LLL  NA VN  + +G TPL +AA+
Sbjct: 649 TLLE-YGAD-ANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQ 706

Query: 866 NGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAA 925
             + N  E+LV+   A +  Q     T LH+ C  G+      +L+       +NA    
Sbjct: 707 EDRVNVAEVLVNQG-AHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAK---VNAKTKN 762

Query: 926 LQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYT 961
             TPLH AA+ G T ++  LL   AS   +  NG T
Sbjct: 763 GYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNT 798



 Score =  318 bits (815), Expect = 2e-86
 Identities = 230/760 (30%), Positives = 375/760 (49%), Gaps = 32/760 (4%)

Query: 19  GDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPL 78
           G  + V  L+ ++ +V+    +  T LH A+  G AE++++L+ +GA VNA+     TPL
Sbjct: 85  GHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPL 144

Query: 79  HRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDR 138
           + A      E V+ LL + A  +   ++  TPL +A      +  + +V LL   +   +
Sbjct: 145 YMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQ----QGHDQVVSLLLENDTKGK 200

Query: 139 AGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAE 198
               ALH AA     +   LLL    N +   K     +H AA+ G+I V  LL++  A 
Sbjct: 201 VRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAA 260

Query: 199 VTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNEL 258
           V    +   TPLH A+  G  ++VK LLD G  ++     G TPLH    +G + VV  L
Sbjct: 261 VDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEML 320

Query: 259 IDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGR 318
           +D  A +  K + G +PLH A    H   C++LL+ +   V+  + D  T LH+ A  G 
Sbjct: 321 LDRAAPILSKTKNGLSPLHMATQGDH-LNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGH 379

Query: 319 FSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHL 378
           +  ++ ++   A  + +  NG TPLHIA +     ++  L+  GA        G+ P+H+
Sbjct: 380 YKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHV 439

Query: 379 AALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFG 438
           AA  G  +   +L+  G   +T +  G T LH AA  G  E +  L+  GA    K K  
Sbjct: 440 AAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDD 499

Query: 439 RSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANP 498
           ++PLH +A       +  L+  GAS N     G TPLH +A    +     +LL + A+ 
Sbjct: 500 QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHE-DVAAFLLDHGASL 558

Query: 499 GIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAA 558
            I  K+G+  +H +A YG    L++       ++L++ S +    D+  ++ ++PLH+AA
Sbjct: 559 SITTKKGFTPLHVAAKYGK---LEV------ANLLLQKSAS---PDAAGKSGLTPLHVAA 606

Query: 559 YHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQG--ASILVKDYIL 616
           ++ + +   +L+           +G TPL +AA K  ++    L+  G  A+ + +  I 
Sbjct: 607 HYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGI- 665

Query: 617 KRTPIHAAATNGHSECLRLLIGNAEPQNA-VDIQDGNGQTPLMLSVLNGHTDCVYSLLNK 675
               +H AA  GH + + LL+G    +NA V++ + +G TPL L+      +    L+N+
Sbjct: 666 --ASVHLAAQEGHVDMVSLLLG----RNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQ 719

Query: 676 GANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVL 735
           GA+VDA+ K G T LH G   G+ + V+ LLQH AK   +   G TP+H +A  GH  ++
Sbjct: 720 GAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHII 779

Query: 736 GALLQSAASMDANPATADNHGYTALHWACYNGHETCVELL 775
             LLQ+    +A+P     +G TAL  A   G+ + V+ L
Sbjct: 780 NVLLQN----NASPNELTVNGNTALGIARRLGYISVVDTL 815



 Score =  316 bits (810), Expect = 6e-86
 Identities = 252/846 (29%), Positives = 377/846 (44%), Gaps = 104/846 (12%)

Query: 86  SEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNV--NVSDRAGRTA 143
           +EE  +   KH      R K          A +A    +AL  + + V  N+ ++ G  A
Sbjct: 18  AEEEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNA 77

Query: 144 LHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKD 203
           LH A+  GH E+V  LL R AN++A  KK   A+H A+  G  EVVK+LV++GA V  + 
Sbjct: 78  LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS 137

Query: 204 KKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELID--- 260
           +  +TPL+ AA    + VVK+LLD G   +     G TPL VA   G D VV+ L++   
Sbjct: 138 QNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDT 197

Query: 261 -------------------CGAIVNQ-------KNEKGFTPLHFAAASTHGAL-CLELLV 293
                                A++ Q       +++ GFTPLH AA   +G +    LL+
Sbjct: 198 KGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAA--HYGNINVATLLL 255

Query: 294 GNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHEL 353
              A V+  +++  TPLH+ +  G  +  + ++  GA ID + ++G TPLH  AR GHE 
Sbjct: 256 NRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQ 315

Query: 354 LINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAA 413
           ++  L+   A    +  +G+ PLH+A      +C + LL     +D   +   T LH AA
Sbjct: 316 VVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAA 375

Query: 414 AGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCT 473
             G+ +   +LL+  A+ N K   G +PLH A      + +  L+  GAS+  + E G T
Sbjct: 376 HCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLT 435

Query: 474 PLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIA-------- 525
           P+H AA        +  L+ + A+P   + +G  A+H +A  G    ++ +         
Sbjct: 436 PIHVAAFMG-HVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEA 494

Query: 526 ----SETPLDVLMETSGTDMLSD------SDNRATIS---PLHLAAYHGHHQALEVLVQS 572
                +TPL +       D++        S N AT S   PLHL+A  GH      L+  
Sbjct: 495 KAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDH 554

Query: 573 LLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKR--TPIHAAA-TNGH 629
              L +    G TPL +AA  G +E  ++L+ + AS    D   K   TP+H AA  +  
Sbjct: 555 GASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSAS---PDAAGKSGLTPLHVAAHYDNQ 611

Query: 630 SECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTA 689
              L LL   A P  A      NG TPL ++      D   +LL  GA+ +A  + G  +
Sbjct: 612 KVALLLLDQGASPHAAAK----NGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIAS 667

Query: 690 LHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANP 749
           +H  A  GH + V  LL   A   L +  G TP+HL+A    + V   L+   A +DA  
Sbjct: 668 VHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQ- 726

Query: 750 ATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLID 809
                 GYT LH  C+ G+   V  LL+                                
Sbjct: 727 ---TKMGYTPLHVGCHYGNIKIVNFLLQH------------------------------- 752

Query: 810 TLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQT 869
              ++ VNA    G TPLH AA   H   + +LL +NA  N +   G T L +A   G  
Sbjct: 753 ---SAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYI 809

Query: 870 NTVEML 875
           + V+ L
Sbjct: 810 SVVDTL 815



 Score =  302 bits (773), Expect = 1e-81
 Identities = 241/768 (31%), Positives = 377/768 (49%), Gaps = 41/768 (5%)

Query: 202 KDKKSYTPLHA----AASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNE 257
           +D+K  +  +A    AA +G +      +  GVD+N  N  G   LH+A   G   VV+E
Sbjct: 33  RDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSE 92

Query: 258 LIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHG 317
           L+   A V+   +KG T LH A+ +    + +++LV NGA+VN +S++G TPL+M A   
Sbjct: 93  LLQREANVDAATKKGNTALHIASLAGQAEV-VKVLVTNGANVNAQSQNGFTPLYMAAQEN 151

Query: 318 RFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLH 377
                + ++ +GA      ++G TPL +A + GH+ +++ L+ +  DT  +G   +  LH
Sbjct: 152 HLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN--DT--KGKVRLPALH 207

Query: 378 LAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKF 437
           +AA    +     LL +  + D     G T LH AA  GN+    LLLN  A  +   + 
Sbjct: 208 IAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARN 267

Query: 438 GRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDAN 497
             +PLH A+   N   +  L+  GA ++     G TPLH  A S  + + +E LL   A 
Sbjct: 268 DITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHE-QVVEMLLDRAAP 326

Query: 498 PGIRDKQGYNAVHYSAAYGHRLCLQLIASET-PLDVLMETSGTDMLSDSDNRATISPLHL 556
              + K G + +H +    H  C+QL+     P+D        D+ +D      ++ LH+
Sbjct: 327 ILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVD--------DVTNDY-----LTALHV 373

Query: 557 AAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI-LVKDYI 615
           AA+ GH++  +VL+    + + +  +G TPL +A  K  ++ +++L+  GASI  V +  
Sbjct: 374 AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESG 433

Query: 616 LKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNK 675
           L  TPIH AA  GH   +  L+ +    N  +++   G+T L ++  +G  + V  L+  
Sbjct: 434 L--TPIHVAAFMGHVNIVSQLMHHGASPNTTNVR---GETALHMAARSGQAEVVRYLVQD 488

Query: 676 GANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVL 735
           GA V+AK K  +T LH  A  G  + V  LLQ GA      + G TP+HLSA  GH  V 
Sbjct: 489 GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVA 548

Query: 736 GALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNA-FSPLHC 794
             LL   AS+    +     G+T LH A   G      LLL++       G +  +PLH 
Sbjct: 549 AFLLDHGASL----SITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHV 604

Query: 795 AVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDS 854
           A   DN+  A +L+D  GAS  +A    G TPLH AA  + ++    LL + A  N+V  
Sbjct: 605 AAHYDNQKVALLLLDQ-GAS-PHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTR 662

Query: 855 TGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKIT 914
            G   + +AA+ G  + V +L+   +A + L + S  T LHLA  +     A +++ +  
Sbjct: 663 QGIASVHLAAQEGHVDMVSLLLGR-NANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGA 721

Query: 915 DRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 962
               ++A      TPLHV    G   +V  LL   A V A  +NGYTP
Sbjct: 722 H---VDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTP 766



 Score =  268 bits (684), Expect = 3e-71
 Identities = 172/534 (32%), Positives = 264/534 (49%), Gaps = 6/534 (1%)

Query: 3   FLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLIL 62
           F    D   L  A   G+ + V+ L+ +   ++ +  +  TPLH  A  G  +++E+L+ 
Sbjct: 263 FTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLD 322

Query: 63  SGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKC 122
             A + +K    L+PLH A        VQ+LL+H+  V+    ++ T LH+AA     K 
Sbjct: 323 RAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKV 382

Query: 123 AEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAY 182
           A+ L+   +N N     G T LH A      ++++LLL  GA+I A  +     IH AA+
Sbjct: 383 AKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAF 442

Query: 183 MGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTP 242
           MGH+ +V  L+ HGA     + +  T LH AA SG   VV+YL+  G  +        TP
Sbjct: 443 MGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 502

Query: 243 LHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMK 302
           LH++   G+  +V +L+  GA  N     G+TPLH +A   H  +    L+ +GA +++ 
Sbjct: 503 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVA-AFLLDHGASLSIT 561

Query: 303 SKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSG 362
           +K G TPLH+ A +G+   +  ++Q  A  D   K+G TPLH+AA Y ++ +   L+  G
Sbjct: 562 TKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQG 621

Query: 363 ADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLN 422
           A       +G  PLH+AA     D    LL  G D +     G   +H AA  G+++ ++
Sbjct: 622 ASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVS 681

Query: 423 LLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSD 482
           LLL   A+ N  +K G +PLH AA          LV  GA V+   + G TPLH      
Sbjct: 682 LLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYG 741

Query: 483 TDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGH----RLCLQLIASETPLDV 532
            + K + +LL++ A    + K GY  +H +A  GH     + LQ  AS   L V
Sbjct: 742 -NIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTV 794



 Score =  162 bits (409), Expect = 2e-39
 Identities = 106/353 (30%), Positives = 169/353 (47%), Gaps = 34/353 (9%)

Query: 6   LRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGA 65
           +R + +L  A  +G  + VR L+     V  +  + +TPLH +A LG A+I++ L+  GA
Sbjct: 464 VRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGA 523

Query: 66  RVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEA 125
             NA  +   TPLH +     E+    LL H A ++   K   TPLH+AA    ++ A  
Sbjct: 524 SPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANL 583

Query: 126 LVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGAN-------------------- 165
           L+   ++ + + ++G T LH AA   + ++  LLL +GA+                    
Sbjct: 584 LLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQ 643

Query: 166 -------------INAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHA 212
                         NA  ++   ++H AA  GH+++V LL+   A V   +K   TPLH 
Sbjct: 644 MDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHL 703

Query: 213 AASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKG 272
           AA    ++V + L++ G  ++     G TPLHV C+ G   +VN L+   A VN K + G
Sbjct: 704 AAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNG 763

Query: 273 FTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTI 325
           +TPLH AA   H  + + +L+ N A  N  + +G T L +    G  S   T+
Sbjct: 764 YTPLHQAAQQGHTHI-INVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 26/75 (34%), Positives = 40/75 (53%), Gaps = 3/75 (4%)

Query: 893 ALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASV 952
           ALHLA  +GH      +L++  +   ++A      T LH+A+  G   VV+ L+  GA+V
Sbjct: 77  ALHLASKEGHVEVVSELLQREAN---VDAATKKGNTALHIASLAGQAEVVKVLVTNGANV 133

Query: 953 LAVDENGYTPALACA 967
            A  +NG+TP    A
Sbjct: 134 NAQSQNGFTPLYMAA 148


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  327 bits (839), Expect = 3e-89
 Identities = 248/808 (30%), Positives = 385/808 (47%), Gaps = 43/808 (5%)

Query: 80  RAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRA 139
           RA  + + + V   LK   D+N  ++N    LH+AA    V   + L+   S+V+ + + 
Sbjct: 16  RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 75

Query: 140 GRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEV 199
           G TALH A+ +G  E+VK+L+  GANINA  +     ++ AA   HI+VVK L+ +GA  
Sbjct: 76  GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 135

Query: 200 TCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTP-LHVACYNGQDVVV--- 255
           +   +  +TPL  A   G    V  LL+     N+       P LH+A            
Sbjct: 136 STATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKSAALL 190

Query: 256 -----NELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPL 310
                N  +    +VN+  E GFTPLH AA   +  +   LL+  GA V+  +++G TPL
Sbjct: 191 LQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA-TLLLNRGAAVDFTARNGITPL 249

Query: 311 HMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGI 370
           H+ +  G  +  + ++  G  ID + ++G TPLH AAR GH+ ++  L+  GA    R  
Sbjct: 250 HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 309

Query: 371 HGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGAD 430
           +G+ PLH+AA     +C + LL     +D       T LH AA  G+     LLL+  A+
Sbjct: 310 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 369

Query: 431 FNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEY 490
            N +   G +PLH A      + +  LV  GAS+  + E G TP+H AA        L  
Sbjct: 370 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVL-L 428

Query: 491 LLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRAT 550
           LL+N A+P + + +G  A+H +A  G             ++V+        L D+  R  
Sbjct: 429 LLQNGASPDVTNIRGETALHMAARAGQ------------VEVVRCLLRNGALVDARAREE 476

Query: 551 ISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGA--S 608
            +PLH+A+  G  + +++L+Q +   D   ++G TPL ++A +G V+   VL+  GA  S
Sbjct: 477 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 536

Query: 609 ILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDC 668
           +  K      TP+H AA  G  +  +LL+   + + A D    NG TPL ++    +   
Sbjct: 537 LATKKGF---TPLHVAAKYGSLDVAKLLL---QRRAAADSAGKNGLTPLHVAAHYDNQKV 590

Query: 669 VYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAA 728
              LL KGA+  A  K G T LH  A     +    LL +GA+  +   +G TP+HL++ 
Sbjct: 591 ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 650

Query: 729 CGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGN- 787
            GH  ++  LL   A++  +  +    G T+LH A         ++L +    Q      
Sbjct: 651 EGHTDMVTLLLDKGANIHMSTKS----GLTSLHLAAQEDKVNVADILTKHGADQDAHTKL 706

Query: 788 AFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNA 847
            ++PL  A    N      L+   GA+ VNA    G TPLH AA   H   + +LL H A
Sbjct: 707 GYTPLIVACHYGNVKMVNFLLKQ-GAN-VNAKTKNGYTPLHQAAQQGHTHIINVLLQHGA 764

Query: 848 QVNSVDSTGKTPLMMAAENGQTNTVEML 875
           + N+  + G T L +A   G  + V+ L
Sbjct: 765 KPNATTANGNTALAIAKRLGYISVVDTL 792



 Score =  313 bits (803), Expect = 4e-85
 Identities = 246/764 (32%), Positives = 386/764 (50%), Gaps = 46/764 (6%)

Query: 210 LHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKN 269
           L AA +  +  VV+YL   G+D+N  N  G   LH+A   G   +V EL+  G+ V+   
Sbjct: 15  LRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSAT 73

Query: 270 EKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSG 329
           +KG T LH A+ +    + +++LV  GA++N +S++G TPL+M A        + ++++G
Sbjct: 74  KKGNTALHIASLAGQAEV-VKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 132

Query: 330 AVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCR 389
           A      ++G TPL +A + GH   +  L+ +  DT  +G   +  LH+AA    +    
Sbjct: 133 ANQSTATEDGFTPLAVALQQGHNQAVAILLEN--DT--KGKVRLPALHIAARKDDTKSAA 188

Query: 390 KLLSSGFDIDTPD--------DFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSP 441
            LL +  + D           + G T LH AA  GN+    LLLN GA  +   + G +P
Sbjct: 189 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 248

Query: 442 LHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIR 501
           LH A+   N   +  L+  G  ++     G TPLH AA S  D + +E LL   A    R
Sbjct: 249 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHD-QVVELLLERGAPLLAR 307

Query: 502 DKQGYNAVHYSAAYGHRLCLQ-LIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYH 560
            K G + +H +A   H  C++ L+  + P+D        D+  D      ++ LH+AA+ 
Sbjct: 308 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVD--------DVTLDY-----LTALHVAAHC 354

Query: 561 GHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI-LVKDYILKRT 619
           GH++  ++L+    + + R  +G TPL +A  K  ++ +++L+  GASI  + +  L  T
Sbjct: 355 GHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGL--T 412

Query: 620 PIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANV 679
           PIH AA  GH   + LL+ N    +  +I+   G+T L ++   G  + V  LL  GA V
Sbjct: 413 PIHVAAFMGHLNIVLLLLQNGASPDVTNIR---GETALHMAARAGQVEVVRCLLRNGALV 469

Query: 680 DAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALL 739
           DA+ +  +T LH  +  G  E V  LLQH A      + G TP+H+SA  G + V   LL
Sbjct: 470 DARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLL 529

Query: 740 QSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEG-NAFSPLHCAVIN 798
           ++ A+     + A   G+T LH A   G     +LLL++     + G N  +PLH A   
Sbjct: 530 EAGAAH----SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHY 585

Query: 799 DNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKT 858
           DN+  A +L++  GAS  +AT   G TPLH AA  + ++    LL++ A+ N V   G T
Sbjct: 586 DNQKVALLLLEK-GAS-PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT 643

Query: 859 PLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNL 918
           PL +A++ G T+ V +L+    A + +   S  T+LHLA  +     A ++ +   D++ 
Sbjct: 644 PLHLASQEGHTDMVTLLLDKG-ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD- 701

Query: 919 INATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 962
             A      TPL VA   G   +V  LL +GA+V A  +NGYTP
Sbjct: 702 --AHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTP 743



 Score =  297 bits (761), Expect = 3e-80
 Identities = 236/777 (30%), Positives = 363/777 (46%), Gaps = 38/777 (4%)

Query: 11  SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
           S ++A   G+ D+V   +    D+N  +      LH AA  G   +++ L+  G+ V++ 
Sbjct: 13  SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 72

Query: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
             K  T LH A  +   E V+VL+K  A++NA+ +N  TPL++AA    +   + L+   
Sbjct: 73  TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 132

Query: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 190
           +N + +   G T L  A   GH + V +LL          K    A+H AA     +   
Sbjct: 133 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK----GKVRLPALHIAARKDDTKSAA 188

Query: 191 LLV--SHGAEVTCK------DKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTP 242
           LL+   H A+V  K       +  +TPLH AA  G ++V   LL+ G  ++     G TP
Sbjct: 189 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 248

Query: 243 LHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMK 302
           LHVA   G   +V  L+D G  ++ K   G TPLH AA S H  + +ELL+  GA +  +
Sbjct: 249 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQV-VELLLERGAPLLAR 307

Query: 303 SKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSG 362
           +K+G +PLHM A        + ++Q  A +D    +  T LH+AA  GH  +   L+   
Sbjct: 308 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR 367

Query: 363 ADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLN 422
           A+   R ++G  PLH+A           L+  G  I    + G T +H AA  G+L  + 
Sbjct: 368 ANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVL 427

Query: 423 LLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSD 482
           LLL  GA  +  +  G + LH AA     + +  L+ +GA V+       TPLH A+   
Sbjct: 428 LLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLG 487

Query: 483 TDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDML 542
              + ++ LL++ A+P      GY  +H SA  G               VL+E      L
Sbjct: 488 KT-EIVQLLLQHMAHPDAATTNGYTPLHISAREG---------QVDVASVLLEAGAAHSL 537

Query: 543 SDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL 602
           +    +   +PLH+AA +G     ++L+Q     D    +G TPL +AA   + +   +L
Sbjct: 538 A---TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 594

Query: 603 INQGAS--ILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLS 660
           + +GAS     K+     TP+H AA     +    L+      N V  Q   G TPL L+
Sbjct: 595 LEKGASPHATAKN---GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ---GVTPLHLA 648

Query: 661 VLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR 720
              GHTD V  LL+KGAN+    K G T+LH  A        D L +HGA        G 
Sbjct: 649 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 708

Query: 721 TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLE 777
           TP+ ++   G++ ++  LL+  A+++A       +GYT LH A   GH   + +LL+
Sbjct: 709 TPLIVACHYGNVKMVNFLLKQGANVNAK----TKNGYTPLHQAAQQGHTHIINVLLQ 761



 Score =  273 bits (699), Expect = 5e-73
 Identities = 205/636 (32%), Positives = 295/636 (46%), Gaps = 26/636 (4%)

Query: 45  LHAAAYLGDAEIIELL--------ILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKH 96
           LH AA   D +   LL        + S   VN       TPLH A    +     +LL  
Sbjct: 175 LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 234

Query: 97  SADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMV 156
            A V+   +N  TPLH+A+        + L+     ++   R G T LH AA SGH ++V
Sbjct: 235 GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVV 294

Query: 157 KLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASS 216
           +LLL RGA + A  K     +H AA   H+E VK L+ H A V        T LH AA  
Sbjct: 295 ELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHC 354

Query: 217 GMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPL 276
           G   V K LLD   + N     G TPLH+AC   +  V+  L+  GA +    E G TP+
Sbjct: 355 GHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 414

Query: 277 HFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCED 336
           H AA   H  + L LL+ NGA  ++ +  G+T LHM A  G+    + ++++GA++D   
Sbjct: 415 HVAAFMGHLNIVL-LLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 473

Query: 337 KNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGF 396
           +   TPLHIA+R G   ++  L+   A       +G  PLH++A  G  D    LL +G 
Sbjct: 474 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 533

Query: 397 DIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFA 456
                   G T LH AA  G+L+   LLL   A  +   K G +PLH AA   N +    
Sbjct: 534 AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALL 593

Query: 457 LVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYG 516
           L+  GAS +   + G TPLH AA  +   +    LL   A   I  KQG   +H ++  G
Sbjct: 594 LLEKGASPHATAKNGYTPLHIAAKKN-QMQIASTLLNYGAETNIVTKQGVTPLHLASQEG 652

Query: 517 HRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDL 576
           H          T +  L+   G ++      ++ ++ LHLAA        ++L +   D 
Sbjct: 653 H----------TDMVTLLLDKGANI--HMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ 700

Query: 577 DVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLL 636
           D     G TPL +A   G+V+ V+ L+ QGA++  K      TP+H AA  GH+  + +L
Sbjct: 701 DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTK-NGYTPLHQAAQQGHTHIINVL 759

Query: 637 IGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSL 672
           + +    NA      NG T L ++   G+   V +L
Sbjct: 760 LQHGAKPNAT---TANGNTALAIAKRLGYISVVDTL 792



 Score =  261 bits (666), Expect = 3e-69
 Identities = 183/584 (31%), Positives = 289/584 (49%), Gaps = 14/584 (2%)

Query: 19  GDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPL 78
           G+ +    L+ +   V+F      TPLH A+  G+  +++LL+  G +++AK    LTPL
Sbjct: 223 GNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPL 282

Query: 79  HRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDR 138
           H A  S  ++ V++LL+  A + AR KN  +PLH+AA    V+C + L+   + V+    
Sbjct: 283 HCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTL 342

Query: 139 AGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAE 198
              TALH AA  GH  + KLLL + AN NA        +H A     I+V++LLV +GA 
Sbjct: 343 DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 402

Query: 199 VTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNEL 258
           +    +   TP+H AA  G +++V  LL  G   +  N  G T LH+A   GQ  VV  L
Sbjct: 403 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 462

Query: 259 IDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGR 318
           +  GA+V+ +  +  TPLH A+      + ++LL+ + A  +  + +G TPLH++A  G+
Sbjct: 463 LRNGALVDARAREEQTPLHIASRLGKTEI-VQLLLQHMAHPDAATTNGYTPLHISAREGQ 521

Query: 319 FSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHL 378
              +  ++++GA      K G TPLH+AA+YG   +   L+   A     G +G+ PLH+
Sbjct: 522 VDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHV 581

Query: 379 AALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFG 438
           AA          LL  G         G T LH AA    ++  + LLN GA+ N   K G
Sbjct: 582 AAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQG 641

Query: 439 RSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANP 498
            +PLH A+   +   +  L+  GA+++   + G T LH AA  D      + L ++ A+ 
Sbjct: 642 VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED-KVNVADILTKHGADQ 700

Query: 499 GIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAA 558
               K GY  +  +  YG+   +  +  +          G ++ + + N  T  PLH AA
Sbjct: 701 DAHTKLGYTPLIVACHYGNVKMVNFLLKQ----------GANVNAKTKNGYT--PLHQAA 748

Query: 559 YHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL 602
             GH   + VL+Q     +   ++G T L +A   G++  VD L
Sbjct: 749 QQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792



 Score =  187 bits (474), Expect = 6e-47
 Identities = 124/370 (33%), Positives = 184/370 (49%), Gaps = 1/370 (0%)

Query: 15  AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 74
           A F G  + V  L+      +  +    T LH AA  G  E++  L+ +GA V+A+  + 
Sbjct: 417 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 476

Query: 75  LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVN 134
            TPLH A      E VQ+LL+H A  +A   N  TPLHI+A    V  A  L+   +  +
Sbjct: 477 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 536

Query: 135 VSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVS 194
           ++ + G T LH AA  G  ++ KLLL R A  ++  K     +H AA+  + +V  LL+ 
Sbjct: 537 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 596

Query: 195 HGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVV 254
            GA      K  YTPLH AA    + +   LL+ G + N     G TPLH+A   G   +
Sbjct: 597 KGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDM 656

Query: 255 VNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTA 314
           V  L+D GA ++   + G T LH AA      +  ++L  +GAD +  +K G TPL +  
Sbjct: 657 VTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVA-DILTKHGADQDAHTKLGYTPLIVAC 715

Query: 315 LHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMF 374
            +G       +++ GA ++ + KNG TPLH AA+ GH  +IN L+  GA       +G  
Sbjct: 716 HYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNT 775

Query: 375 PLHLAALSGF 384
            L +A   G+
Sbjct: 776 ALAIAKRLGY 785



 Score =  169 bits (429), Expect = 1e-41
 Identities = 113/353 (32%), Positives = 178/353 (50%), Gaps = 1/353 (0%)

Query: 6   LRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGA 65
           +R + +L  A   G  + VR L+     V+ +  E++TPLH A+ LG  EI++LL+   A
Sbjct: 441 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMA 500

Query: 66  RVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEA 125
             +A  +   TPLH +      +   VLL+  A  +   K   TPLH+AA   ++  A+ 
Sbjct: 501 HPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKL 560

Query: 126 LVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGH 185
           L+   +  + + + G T LH AA   + ++  LLL +GA+ +A  K     +H AA    
Sbjct: 561 LLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQ 620

Query: 186 IEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245
           +++   L+++GAE     K+  TPLH A+  G   +V  LLD G +++     G T LH+
Sbjct: 621 MQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHL 680

Query: 246 ACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 305
           A    +  V + L   GA  +   + G+TPL   A        +  L+  GA+VN K+K+
Sbjct: 681 AAQEDKVNVADILTKHGADQDAHTKLGYTPL-IVACHYGNVKMVNFLLKQGANVNAKTKN 739

Query: 306 GKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTL 358
           G TPLH  A  G       ++Q GA  +    NGNT L IA R G+  +++TL
Sbjct: 740 GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 57/168 (33%), Positives = 78/168 (46%)

Query: 33  DVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQV 92
           + N    +  TPLH A+  G  +++ LL+  GA ++      LT LH A          +
Sbjct: 633 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADI 692

Query: 93  LLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGH 152
           L KH AD +A  K   TPL +A     VK    L+   +NVN   + G T LH AA  GH
Sbjct: 693 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 752

Query: 153 GEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVT 200
             ++ +LL  GA  NA       A+  A  +G+I VV  L     EVT
Sbjct: 753 THIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVT 800


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  327 bits (839), Expect = 3e-89
 Identities = 248/808 (30%), Positives = 385/808 (47%), Gaps = 43/808 (5%)

Query: 80  RAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRA 139
           RA  + + + V   LK   D+N  ++N    LH+AA    V   + L+   S+V+ + + 
Sbjct: 37  RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 96

Query: 140 GRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEV 199
           G TALH A+ +G  E+VK+L+  GANINA  +     ++ AA   HI+VVK L+ +GA  
Sbjct: 97  GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 156

Query: 200 TCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTP-LHVACYNGQDVVV--- 255
           +   +  +TPL  A   G    V  LL+     N+       P LH+A            
Sbjct: 157 STATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKSAALL 211

Query: 256 -----NELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPL 310
                N  +    +VN+  E GFTPLH AA   +  +   LL+  GA V+  +++G TPL
Sbjct: 212 LQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA-TLLLNRGAAVDFTARNGITPL 270

Query: 311 HMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGI 370
           H+ +  G  +  + ++  G  ID + ++G TPLH AAR GH+ ++  L+  GA    R  
Sbjct: 271 HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330

Query: 371 HGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGAD 430
           +G+ PLH+AA     +C + LL     +D       T LH AA  G+     LLL+  A+
Sbjct: 331 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 390

Query: 431 FNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEY 490
            N +   G +PLH A      + +  LV  GAS+  + E G TP+H AA        L  
Sbjct: 391 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVL-L 449

Query: 491 LLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRAT 550
           LL+N A+P + + +G  A+H +A  G             ++V+        L D+  R  
Sbjct: 450 LLQNGASPDVTNIRGETALHMAARAGQ------------VEVVRCLLRNGALVDARAREE 497

Query: 551 ISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGA--S 608
            +PLH+A+  G  + +++L+Q +   D   ++G TPL ++A +G V+   VL+  GA  S
Sbjct: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557

Query: 609 ILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDC 668
           +  K      TP+H AA  G  +  +LL+   + + A D    NG TPL ++    +   
Sbjct: 558 LATKKGF---TPLHVAAKYGSLDVAKLLL---QRRAAADSAGKNGLTPLHVAAHYDNQKV 611

Query: 669 VYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAA 728
              LL KGA+  A  K G T LH  A     +    LL +GA+  +   +G TP+HL++ 
Sbjct: 612 ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 671

Query: 729 CGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGN- 787
            GH  ++  LL   A++  +  +    G T+LH A         ++L +    Q      
Sbjct: 672 EGHTDMVTLLLDKGANIHMSTKS----GLTSLHLAAQEDKVNVADILTKHGADQDAHTKL 727

Query: 788 AFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNA 847
            ++PL  A    N      L+   GA+ VNA    G TPLH AA   H   + +LL H A
Sbjct: 728 GYTPLIVACHYGNVKMVNFLLKQ-GAN-VNAKTKNGYTPLHQAAQQGHTHIINVLLQHGA 785

Query: 848 QVNSVDSTGKTPLMMAAENGQTNTVEML 875
           + N+  + G T L +A   G  + V+ L
Sbjct: 786 KPNATTANGNTALAIAKRLGYISVVDTL 813



 Score =  313 bits (803), Expect = 4e-85
 Identities = 246/764 (32%), Positives = 386/764 (50%), Gaps = 46/764 (6%)

Query: 210 LHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKN 269
           L AA +  +  VV+YL   G+D+N  N  G   LH+A   G   +V EL+  G+ V+   
Sbjct: 36  LRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSAT 94

Query: 270 EKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSG 329
           +KG T LH A+ +    + +++LV  GA++N +S++G TPL+M A        + ++++G
Sbjct: 95  KKGNTALHIASLAGQAEV-VKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153

Query: 330 AVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCR 389
           A      ++G TPL +A + GH   +  L+ +  DT  +G   +  LH+AA    +    
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILLEN--DT--KGKVRLPALHIAARKDDTKSAA 209

Query: 390 KLLSSGFDIDTPD--------DFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSP 441
            LL +  + D           + G T LH AA  GN+    LLLN GA  +   + G +P
Sbjct: 210 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 269

Query: 442 LHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIR 501
           LH A+   N   +  L+  G  ++     G TPLH AA S  D + +E LL   A    R
Sbjct: 270 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHD-QVVELLLERGAPLLAR 328

Query: 502 DKQGYNAVHYSAAYGHRLCLQ-LIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYH 560
            K G + +H +A   H  C++ L+  + P+D        D+  D      ++ LH+AA+ 
Sbjct: 329 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVD--------DVTLDY-----LTALHVAAHC 375

Query: 561 GHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI-LVKDYILKRT 619
           GH++  ++L+    + + R  +G TPL +A  K  ++ +++L+  GASI  + +  L  T
Sbjct: 376 GHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGL--T 433

Query: 620 PIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANV 679
           PIH AA  GH   + LL+ N    +  +I+   G+T L ++   G  + V  LL  GA V
Sbjct: 434 PIHVAAFMGHLNIVLLLLQNGASPDVTNIR---GETALHMAARAGQVEVVRCLLRNGALV 490

Query: 680 DAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALL 739
           DA+ +  +T LH  +  G  E V  LLQH A      + G TP+H+SA  G + V   LL
Sbjct: 491 DARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLL 550

Query: 740 QSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEG-NAFSPLHCAVIN 798
           ++ A+     + A   G+T LH A   G     +LLL++     + G N  +PLH A   
Sbjct: 551 EAGAAH----SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHY 606

Query: 799 DNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKT 858
           DN+  A +L++  GAS  +AT   G TPLH AA  + ++    LL++ A+ N V   G T
Sbjct: 607 DNQKVALLLLEK-GAS-PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT 664

Query: 859 PLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNL 918
           PL +A++ G T+ V +L+    A + +   S  T+LHLA  +     A ++ +   D++ 
Sbjct: 665 PLHLASQEGHTDMVTLLLDKG-ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD- 722

Query: 919 INATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 962
             A      TPL VA   G   +V  LL +GA+V A  +NGYTP
Sbjct: 723 --AHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTP 764



 Score =  297 bits (761), Expect = 3e-80
 Identities = 236/777 (30%), Positives = 363/777 (46%), Gaps = 38/777 (4%)

Query: 11  SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
           S ++A   G+ D+V   +    D+N  +      LH AA  G   +++ L+  G+ V++ 
Sbjct: 34  SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93

Query: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
             K  T LH A  +   E V+VL+K  A++NA+ +N  TPL++AA    +   + L+   
Sbjct: 94  TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153

Query: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 190
           +N + +   G T L  A   GH + V +LL          K    A+H AA     +   
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK----GKVRLPALHIAARKDDTKSAA 209

Query: 191 LLV--SHGAEVTCK------DKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTP 242
           LL+   H A+V  K       +  +TPLH AA  G ++V   LL+ G  ++     G TP
Sbjct: 210 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 269

Query: 243 LHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMK 302
           LHVA   G   +V  L+D G  ++ K   G TPLH AA S H  + +ELL+  GA +  +
Sbjct: 270 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQV-VELLLERGAPLLAR 328

Query: 303 SKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSG 362
           +K+G +PLHM A        + ++Q  A +D    +  T LH+AA  GH  +   L+   
Sbjct: 329 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR 388

Query: 363 ADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLN 422
           A+   R ++G  PLH+A           L+  G  I    + G T +H AA  G+L  + 
Sbjct: 389 ANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVL 448

Query: 423 LLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSD 482
           LLL  GA  +  +  G + LH AA     + +  L+ +GA V+       TPLH A+   
Sbjct: 449 LLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLG 508

Query: 483 TDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDML 542
              + ++ LL++ A+P      GY  +H SA  G               VL+E      L
Sbjct: 509 KT-EIVQLLLQHMAHPDAATTNGYTPLHISAREG---------QVDVASVLLEAGAAHSL 558

Query: 543 SDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL 602
           +    +   +PLH+AA +G     ++L+Q     D    +G TPL +AA   + +   +L
Sbjct: 559 A---TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615

Query: 603 INQGAS--ILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLS 660
           + +GAS     K+     TP+H AA     +    L+      N V  Q   G TPL L+
Sbjct: 616 LEKGASPHATAKN---GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ---GVTPLHLA 669

Query: 661 VLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR 720
              GHTD V  LL+KGAN+    K G T+LH  A        D L +HGA        G 
Sbjct: 670 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 729

Query: 721 TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLE 777
           TP+ ++   G++ ++  LL+  A+++A       +GYT LH A   GH   + +LL+
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAK----TKNGYTPLHQAAQQGHTHIINVLLQ 782



 Score =  273 bits (699), Expect = 5e-73
 Identities = 205/636 (32%), Positives = 295/636 (46%), Gaps = 26/636 (4%)

Query: 45  LHAAAYLGDAEIIELL--------ILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKH 96
           LH AA   D +   LL        + S   VN       TPLH A    +     +LL  
Sbjct: 196 LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 255

Query: 97  SADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMV 156
            A V+   +N  TPLH+A+        + L+     ++   R G T LH AA SGH ++V
Sbjct: 256 GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVV 315

Query: 157 KLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASS 216
           +LLL RGA + A  K     +H AA   H+E VK L+ H A V        T LH AA  
Sbjct: 316 ELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHC 375

Query: 217 GMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPL 276
           G   V K LLD   + N     G TPLH+AC   +  V+  L+  GA +    E G TP+
Sbjct: 376 GHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 435

Query: 277 HFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCED 336
           H AA   H  + L LL+ NGA  ++ +  G+T LHM A  G+    + ++++GA++D   
Sbjct: 436 HVAAFMGHLNIVL-LLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 494

Query: 337 KNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGF 396
           +   TPLHIA+R G   ++  L+   A       +G  PLH++A  G  D    LL +G 
Sbjct: 495 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 554

Query: 397 DIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFA 456
                   G T LH AA  G+L+   LLL   A  +   K G +PLH AA   N +    
Sbjct: 555 AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALL 614

Query: 457 LVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYG 516
           L+  GAS +   + G TPLH AA  +   +    LL   A   I  KQG   +H ++  G
Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAKKN-QMQIASTLLNYGAETNIVTKQGVTPLHLASQEG 673

Query: 517 HRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDL 576
           H          T +  L+   G ++      ++ ++ LHLAA        ++L +   D 
Sbjct: 674 H----------TDMVTLLLDKGANI--HMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ 721

Query: 577 DVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLL 636
           D     G TPL +A   G+V+ V+ L+ QGA++  K      TP+H AA  GH+  + +L
Sbjct: 722 DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTK-NGYTPLHQAAQQGHTHIINVL 780

Query: 637 IGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSL 672
           + +    NA      NG T L ++   G+   V +L
Sbjct: 781 LQHGAKPNAT---TANGNTALAIAKRLGYISVVDTL 813



 Score =  261 bits (666), Expect = 3e-69
 Identities = 183/584 (31%), Positives = 289/584 (49%), Gaps = 14/584 (2%)

Query: 19  GDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPL 78
           G+ +    L+ +   V+F      TPLH A+  G+  +++LL+  G +++AK    LTPL
Sbjct: 244 GNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPL 303

Query: 79  HRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDR 138
           H A  S  ++ V++LL+  A + AR KN  +PLH+AA    V+C + L+   + V+    
Sbjct: 304 HCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTL 363

Query: 139 AGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAE 198
              TALH AA  GH  + KLLL + AN NA        +H A     I+V++LLV +GA 
Sbjct: 364 DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 423

Query: 199 VTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNEL 258
           +    +   TP+H AA  G +++V  LL  G   +  N  G T LH+A   GQ  VV  L
Sbjct: 424 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483

Query: 259 IDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGR 318
           +  GA+V+ +  +  TPLH A+      + ++LL+ + A  +  + +G TPLH++A  G+
Sbjct: 484 LRNGALVDARAREEQTPLHIASRLGKTEI-VQLLLQHMAHPDAATTNGYTPLHISAREGQ 542

Query: 319 FSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHL 378
              +  ++++GA      K G TPLH+AA+YG   +   L+   A     G +G+ PLH+
Sbjct: 543 VDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHV 602

Query: 379 AALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFG 438
           AA          LL  G         G T LH AA    ++  + LLN GA+ N   K G
Sbjct: 603 AAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQG 662

Query: 439 RSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANP 498
            +PLH A+   +   +  L+  GA+++   + G T LH AA  D      + L ++ A+ 
Sbjct: 663 VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED-KVNVADILTKHGADQ 721

Query: 499 GIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAA 558
               K GY  +  +  YG+   +  +  +          G ++ + + N  T  PLH AA
Sbjct: 722 DAHTKLGYTPLIVACHYGNVKMVNFLLKQ----------GANVNAKTKNGYT--PLHQAA 769

Query: 559 YHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL 602
             GH   + VL+Q     +   ++G T L +A   G++  VD L
Sbjct: 770 QQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813



 Score =  187 bits (474), Expect = 6e-47
 Identities = 124/370 (33%), Positives = 184/370 (49%), Gaps = 1/370 (0%)

Query: 15  AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 74
           A F G  + V  L+      +  +    T LH AA  G  E++  L+ +GA V+A+  + 
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497

Query: 75  LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVN 134
            TPLH A      E VQ+LL+H A  +A   N  TPLHI+A    V  A  L+   +  +
Sbjct: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557

Query: 135 VSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVS 194
           ++ + G T LH AA  G  ++ KLLL R A  ++  K     +H AA+  + +V  LL+ 
Sbjct: 558 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 617

Query: 195 HGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVV 254
            GA      K  YTPLH AA    + +   LL+ G + N     G TPLH+A   G   +
Sbjct: 618 KGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDM 677

Query: 255 VNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTA 314
           V  L+D GA ++   + G T LH AA      +  ++L  +GAD +  +K G TPL +  
Sbjct: 678 VTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVA-DILTKHGADQDAHTKLGYTPLIVAC 736

Query: 315 LHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMF 374
            +G       +++ GA ++ + KNG TPLH AA+ GH  +IN L+  GA       +G  
Sbjct: 737 HYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNT 796

Query: 375 PLHLAALSGF 384
            L +A   G+
Sbjct: 797 ALAIAKRLGY 806



 Score =  169 bits (429), Expect = 1e-41
 Identities = 113/353 (32%), Positives = 178/353 (50%), Gaps = 1/353 (0%)

Query: 6   LRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGA 65
           +R + +L  A   G  + VR L+     V+ +  E++TPLH A+ LG  EI++LL+   A
Sbjct: 462 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMA 521

Query: 66  RVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEA 125
             +A  +   TPLH +      +   VLL+  A  +   K   TPLH+AA   ++  A+ 
Sbjct: 522 HPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKL 581

Query: 126 LVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGH 185
           L+   +  + + + G T LH AA   + ++  LLL +GA+ +A  K     +H AA    
Sbjct: 582 LLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQ 641

Query: 186 IEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245
           +++   L+++GAE     K+  TPLH A+  G   +V  LLD G +++     G T LH+
Sbjct: 642 MQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHL 701

Query: 246 ACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 305
           A    +  V + L   GA  +   + G+TPL   A        +  L+  GA+VN K+K+
Sbjct: 702 AAQEDKVNVADILTKHGADQDAHTKLGYTPL-IVACHYGNVKMVNFLLKQGANVNAKTKN 760

Query: 306 GKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTL 358
           G TPLH  A  G       ++Q GA  +    NGNT L IA R G+  +++TL
Sbjct: 761 GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 57/168 (33%), Positives = 78/168 (46%)

Query: 33  DVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQV 92
           + N    +  TPLH A+  G  +++ LL+  GA ++      LT LH A          +
Sbjct: 654 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADI 713

Query: 93  LLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGH 152
           L KH AD +A  K   TPL +A     VK    L+   +NVN   + G T LH AA  GH
Sbjct: 714 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 773

Query: 153 GEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVT 200
             ++ +LL  GA  NA       A+  A  +G+I VV  L     EVT
Sbjct: 774 THIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVT 821


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  327 bits (839), Expect = 3e-89
 Identities = 248/808 (30%), Positives = 385/808 (47%), Gaps = 43/808 (5%)

Query: 80  RAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRA 139
           RA  + + + V   LK   D+N  ++N    LH+AA    V   + L+   S+V+ + + 
Sbjct: 37  RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 96

Query: 140 GRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEV 199
           G TALH A+ +G  E+VK+L+  GANINA  +     ++ AA   HI+VVK L+ +GA  
Sbjct: 97  GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 156

Query: 200 TCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTP-LHVACYNGQDVVV--- 255
           +   +  +TPL  A   G    V  LL+     N+       P LH+A            
Sbjct: 157 STATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKSAALL 211

Query: 256 -----NELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPL 310
                N  +    +VN+  E GFTPLH AA   +  +   LL+  GA V+  +++G TPL
Sbjct: 212 LQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA-TLLLNRGAAVDFTARNGITPL 270

Query: 311 HMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGI 370
           H+ +  G  +  + ++  G  ID + ++G TPLH AAR GH+ ++  L+  GA    R  
Sbjct: 271 HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330

Query: 371 HGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGAD 430
           +G+ PLH+AA     +C + LL     +D       T LH AA  G+     LLL+  A+
Sbjct: 331 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 390

Query: 431 FNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEY 490
            N +   G +PLH A      + +  LV  GAS+  + E G TP+H AA        L  
Sbjct: 391 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVL-L 449

Query: 491 LLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRAT 550
           LL+N A+P + + +G  A+H +A  G             ++V+        L D+  R  
Sbjct: 450 LLQNGASPDVTNIRGETALHMAARAGQ------------VEVVRCLLRNGALVDARAREE 497

Query: 551 ISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGA--S 608
            +PLH+A+  G  + +++L+Q +   D   ++G TPL ++A +G V+   VL+  GA  S
Sbjct: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557

Query: 609 ILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDC 668
           +  K      TP+H AA  G  +  +LL+   + + A D    NG TPL ++    +   
Sbjct: 558 LATKKGF---TPLHVAAKYGSLDVAKLLL---QRRAAADSAGKNGLTPLHVAAHYDNQKV 611

Query: 669 VYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAA 728
              LL KGA+  A  K G T LH  A     +    LL +GA+  +   +G TP+HL++ 
Sbjct: 612 ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 671

Query: 729 CGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGN- 787
            GH  ++  LL   A++  +  +    G T+LH A         ++L +    Q      
Sbjct: 672 EGHTDMVTLLLDKGANIHMSTKS----GLTSLHLAAQEDKVNVADILTKHGADQDAHTKL 727

Query: 788 AFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNA 847
            ++PL  A    N      L+   GA+ VNA    G TPLH AA   H   + +LL H A
Sbjct: 728 GYTPLIVACHYGNVKMVNFLLKQ-GAN-VNAKTKNGYTPLHQAAQQGHTHIINVLLQHGA 785

Query: 848 QVNSVDSTGKTPLMMAAENGQTNTVEML 875
           + N+  + G T L +A   G  + V+ L
Sbjct: 786 KPNATTANGNTALAIAKRLGYISVVDTL 813



 Score =  313 bits (803), Expect = 4e-85
 Identities = 246/764 (32%), Positives = 386/764 (50%), Gaps = 46/764 (6%)

Query: 210 LHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKN 269
           L AA +  +  VV+YL   G+D+N  N  G   LH+A   G   +V EL+  G+ V+   
Sbjct: 36  LRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSAT 94

Query: 270 EKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSG 329
           +KG T LH A+ +    + +++LV  GA++N +S++G TPL+M A        + ++++G
Sbjct: 95  KKGNTALHIASLAGQAEV-VKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153

Query: 330 AVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCR 389
           A      ++G TPL +A + GH   +  L+ +  DT  +G   +  LH+AA    +    
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILLEN--DT--KGKVRLPALHIAARKDDTKSAA 209

Query: 390 KLLSSGFDIDTPD--------DFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSP 441
            LL +  + D           + G T LH AA  GN+    LLLN GA  +   + G +P
Sbjct: 210 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 269

Query: 442 LHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIR 501
           LH A+   N   +  L+  G  ++     G TPLH AA S  D + +E LL   A    R
Sbjct: 270 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHD-QVVELLLERGAPLLAR 328

Query: 502 DKQGYNAVHYSAAYGHRLCLQ-LIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYH 560
            K G + +H +A   H  C++ L+  + P+D        D+  D      ++ LH+AA+ 
Sbjct: 329 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVD--------DVTLDY-----LTALHVAAHC 375

Query: 561 GHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI-LVKDYILKRT 619
           GH++  ++L+    + + R  +G TPL +A  K  ++ +++L+  GASI  + +  L  T
Sbjct: 376 GHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGL--T 433

Query: 620 PIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANV 679
           PIH AA  GH   + LL+ N    +  +I+   G+T L ++   G  + V  LL  GA V
Sbjct: 434 PIHVAAFMGHLNIVLLLLQNGASPDVTNIR---GETALHMAARAGQVEVVRCLLRNGALV 490

Query: 680 DAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALL 739
           DA+ +  +T LH  +  G  E V  LLQH A      + G TP+H+SA  G + V   LL
Sbjct: 491 DARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLL 550

Query: 740 QSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEG-NAFSPLHCAVIN 798
           ++ A+     + A   G+T LH A   G     +LLL++     + G N  +PLH A   
Sbjct: 551 EAGAAH----SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHY 606

Query: 799 DNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKT 858
           DN+  A +L++  GAS  +AT   G TPLH AA  + ++    LL++ A+ N V   G T
Sbjct: 607 DNQKVALLLLEK-GAS-PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT 664

Query: 859 PLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNL 918
           PL +A++ G T+ V +L+    A + +   S  T+LHLA  +     A ++ +   D++ 
Sbjct: 665 PLHLASQEGHTDMVTLLLDKG-ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD- 722

Query: 919 INATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 962
             A      TPL VA   G   +V  LL +GA+V A  +NGYTP
Sbjct: 723 --AHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTP 764



 Score =  297 bits (761), Expect = 3e-80
 Identities = 236/777 (30%), Positives = 363/777 (46%), Gaps = 38/777 (4%)

Query: 11  SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
           S ++A   G+ D+V   +    D+N  +      LH AA  G   +++ L+  G+ V++ 
Sbjct: 34  SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93

Query: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
             K  T LH A  +   E V+VL+K  A++NA+ +N  TPL++AA    +   + L+   
Sbjct: 94  TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153

Query: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 190
           +N + +   G T L  A   GH + V +LL          K    A+H AA     +   
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK----GKVRLPALHIAARKDDTKSAA 209

Query: 191 LLV--SHGAEVTCK------DKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTP 242
           LL+   H A+V  K       +  +TPLH AA  G ++V   LL+ G  ++     G TP
Sbjct: 210 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 269

Query: 243 LHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMK 302
           LHVA   G   +V  L+D G  ++ K   G TPLH AA S H  + +ELL+  GA +  +
Sbjct: 270 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQV-VELLLERGAPLLAR 328

Query: 303 SKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSG 362
           +K+G +PLHM A        + ++Q  A +D    +  T LH+AA  GH  +   L+   
Sbjct: 329 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR 388

Query: 363 ADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLN 422
           A+   R ++G  PLH+A           L+  G  I    + G T +H AA  G+L  + 
Sbjct: 389 ANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVL 448

Query: 423 LLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSD 482
           LLL  GA  +  +  G + LH AA     + +  L+ +GA V+       TPLH A+   
Sbjct: 449 LLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLG 508

Query: 483 TDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDML 542
              + ++ LL++ A+P      GY  +H SA  G               VL+E      L
Sbjct: 509 KT-EIVQLLLQHMAHPDAATTNGYTPLHISAREG---------QVDVASVLLEAGAAHSL 558

Query: 543 SDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL 602
           +    +   +PLH+AA +G     ++L+Q     D    +G TPL +AA   + +   +L
Sbjct: 559 A---TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615

Query: 603 INQGAS--ILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLS 660
           + +GAS     K+     TP+H AA     +    L+      N V  Q   G TPL L+
Sbjct: 616 LEKGASPHATAKN---GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ---GVTPLHLA 669

Query: 661 VLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR 720
              GHTD V  LL+KGAN+    K G T+LH  A        D L +HGA        G 
Sbjct: 670 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 729

Query: 721 TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLE 777
           TP+ ++   G++ ++  LL+  A+++A       +GYT LH A   GH   + +LL+
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAK----TKNGYTPLHQAAQQGHTHIINVLLQ 782



 Score =  273 bits (699), Expect = 5e-73
 Identities = 205/636 (32%), Positives = 295/636 (46%), Gaps = 26/636 (4%)

Query: 45  LHAAAYLGDAEIIELL--------ILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKH 96
           LH AA   D +   LL        + S   VN       TPLH A    +     +LL  
Sbjct: 196 LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 255

Query: 97  SADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMV 156
            A V+   +N  TPLH+A+        + L+     ++   R G T LH AA SGH ++V
Sbjct: 256 GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVV 315

Query: 157 KLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASS 216
           +LLL RGA + A  K     +H AA   H+E VK L+ H A V        T LH AA  
Sbjct: 316 ELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHC 375

Query: 217 GMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPL 276
           G   V K LLD   + N     G TPLH+AC   +  V+  L+  GA +    E G TP+
Sbjct: 376 GHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 435

Query: 277 HFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCED 336
           H AA   H  + L LL+ NGA  ++ +  G+T LHM A  G+    + ++++GA++D   
Sbjct: 436 HVAAFMGHLNIVL-LLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 494

Query: 337 KNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGF 396
           +   TPLHIA+R G   ++  L+   A       +G  PLH++A  G  D    LL +G 
Sbjct: 495 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 554

Query: 397 DIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFA 456
                   G T LH AA  G+L+   LLL   A  +   K G +PLH AA   N +    
Sbjct: 555 AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALL 614

Query: 457 LVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYG 516
           L+  GAS +   + G TPLH AA  +   +    LL   A   I  KQG   +H ++  G
Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAKKN-QMQIASTLLNYGAETNIVTKQGVTPLHLASQEG 673

Query: 517 HRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDL 576
           H          T +  L+   G ++      ++ ++ LHLAA        ++L +   D 
Sbjct: 674 H----------TDMVTLLLDKGANI--HMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ 721

Query: 577 DVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLL 636
           D     G TPL +A   G+V+ V+ L+ QGA++  K      TP+H AA  GH+  + +L
Sbjct: 722 DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTK-NGYTPLHQAAQQGHTHIINVL 780

Query: 637 IGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSL 672
           + +    NA      NG T L ++   G+   V +L
Sbjct: 781 LQHGAKPNAT---TANGNTALAIAKRLGYISVVDTL 813



 Score =  261 bits (666), Expect = 3e-69
 Identities = 183/584 (31%), Positives = 289/584 (49%), Gaps = 14/584 (2%)

Query: 19  GDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPL 78
           G+ +    L+ +   V+F      TPLH A+  G+  +++LL+  G +++AK    LTPL
Sbjct: 244 GNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPL 303

Query: 79  HRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDR 138
           H A  S  ++ V++LL+  A + AR KN  +PLH+AA    V+C + L+   + V+    
Sbjct: 304 HCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTL 363

Query: 139 AGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAE 198
              TALH AA  GH  + KLLL + AN NA        +H A     I+V++LLV +GA 
Sbjct: 364 DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 423

Query: 199 VTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNEL 258
           +    +   TP+H AA  G +++V  LL  G   +  N  G T LH+A   GQ  VV  L
Sbjct: 424 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483

Query: 259 IDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGR 318
           +  GA+V+ +  +  TPLH A+      + ++LL+ + A  +  + +G TPLH++A  G+
Sbjct: 484 LRNGALVDARAREEQTPLHIASRLGKTEI-VQLLLQHMAHPDAATTNGYTPLHISAREGQ 542

Query: 319 FSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHL 378
              +  ++++GA      K G TPLH+AA+YG   +   L+   A     G +G+ PLH+
Sbjct: 543 VDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHV 602

Query: 379 AALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFG 438
           AA          LL  G         G T LH AA    ++  + LLN GA+ N   K G
Sbjct: 603 AAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQG 662

Query: 439 RSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANP 498
            +PLH A+   +   +  L+  GA+++   + G T LH AA  D      + L ++ A+ 
Sbjct: 663 VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED-KVNVADILTKHGADQ 721

Query: 499 GIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAA 558
               K GY  +  +  YG+   +  +  +          G ++ + + N  T  PLH AA
Sbjct: 722 DAHTKLGYTPLIVACHYGNVKMVNFLLKQ----------GANVNAKTKNGYT--PLHQAA 769

Query: 559 YHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL 602
             GH   + VL+Q     +   ++G T L +A   G++  VD L
Sbjct: 770 QQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813



 Score =  187 bits (474), Expect = 6e-47
 Identities = 124/370 (33%), Positives = 184/370 (49%), Gaps = 1/370 (0%)

Query: 15  AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 74
           A F G  + V  L+      +  +    T LH AA  G  E++  L+ +GA V+A+  + 
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497

Query: 75  LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVN 134
            TPLH A      E VQ+LL+H A  +A   N  TPLHI+A    V  A  L+   +  +
Sbjct: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557

Query: 135 VSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVS 194
           ++ + G T LH AA  G  ++ KLLL R A  ++  K     +H AA+  + +V  LL+ 
Sbjct: 558 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 617

Query: 195 HGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVV 254
            GA      K  YTPLH AA    + +   LL+ G + N     G TPLH+A   G   +
Sbjct: 618 KGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDM 677

Query: 255 VNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTA 314
           V  L+D GA ++   + G T LH AA      +  ++L  +GAD +  +K G TPL +  
Sbjct: 678 VTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVA-DILTKHGADQDAHTKLGYTPLIVAC 736

Query: 315 LHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMF 374
            +G       +++ GA ++ + KNG TPLH AA+ GH  +IN L+  GA       +G  
Sbjct: 737 HYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNT 796

Query: 375 PLHLAALSGF 384
            L +A   G+
Sbjct: 797 ALAIAKRLGY 806



 Score =  169 bits (429), Expect = 1e-41
 Identities = 113/353 (32%), Positives = 178/353 (50%), Gaps = 1/353 (0%)

Query: 6   LRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGA 65
           +R + +L  A   G  + VR L+     V+ +  E++TPLH A+ LG  EI++LL+   A
Sbjct: 462 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMA 521

Query: 66  RVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEA 125
             +A  +   TPLH +      +   VLL+  A  +   K   TPLH+AA   ++  A+ 
Sbjct: 522 HPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKL 581

Query: 126 LVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGH 185
           L+   +  + + + G T LH AA   + ++  LLL +GA+ +A  K     +H AA    
Sbjct: 582 LLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQ 641

Query: 186 IEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245
           +++   L+++GAE     K+  TPLH A+  G   +V  LLD G +++     G T LH+
Sbjct: 642 MQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHL 701

Query: 246 ACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 305
           A    +  V + L   GA  +   + G+TPL   A        +  L+  GA+VN K+K+
Sbjct: 702 AAQEDKVNVADILTKHGADQDAHTKLGYTPL-IVACHYGNVKMVNFLLKQGANVNAKTKN 760

Query: 306 GKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTL 358
           G TPLH  A  G       ++Q GA  +    NGNT L IA R G+  +++TL
Sbjct: 761 GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 57/168 (33%), Positives = 78/168 (46%)

Query: 33  DVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQV 92
           + N    +  TPLH A+  G  +++ LL+  GA ++      LT LH A          +
Sbjct: 654 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADI 713

Query: 93  LLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGH 152
           L KH AD +A  K   TPL +A     VK    L+   +NVN   + G T LH AA  GH
Sbjct: 714 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 773

Query: 153 GEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVT 200
             ++ +LL  GA  NA       A+  A  +G+I VV  L     EVT
Sbjct: 774 THIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVT 821


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  327 bits (839), Expect = 3e-89
 Identities = 249/814 (30%), Positives = 388/814 (47%), Gaps = 33/814 (4%)

Query: 65  ARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAE 124
           +R   K +   T   RA  S + +     L++  D+N  ++N    LH+A+    VK   
Sbjct: 36  SRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVV 95

Query: 125 ALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMG 184
            L+     +  + + G TALH AA +G  E+V+ L++ GAN+NA  +K    ++ AA   
Sbjct: 96  ELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQEN 155

Query: 185 HIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLH 244
           H+EVVK L+ +GA      +  +TPL  A   G  +VV +L++ G             LH
Sbjct: 156 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALH 211

Query: 245 VACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSK 304
           +A  N        L+      +  ++ GFTPLH  AA        +LL+  GA VN   +
Sbjct: 212 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI-AAHYENLNVAQLLLNRGASVNFTPQ 270

Query: 305 DGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD 364
           +G TPLH+ +  G     + ++  GA I+ + K+  TPLH AAR GH  +   L+  GA 
Sbjct: 271 NGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 330

Query: 365 TAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLL 424
              +  +G+ P+H+AA     DC R LL    +ID       T LH AA  G+     +L
Sbjct: 331 IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 390

Query: 425 LNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTD 484
           L+ GA  N +   G +PLH A    + + +  L+ +GAS++ + E G TPLH A+     
Sbjct: 391 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMG-H 449

Query: 485 GKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSD 544
              ++ LL+  A+P + + +    +H +A  GH        +E    +L   +  +  + 
Sbjct: 450 LPIVKNLLQRGASPNVSNVKVETPLHMAARAGH--------TEVAKYLLQNKAKVNAKAK 501

Query: 545 SDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLIN 604
            D     +PLH AA  GH   +++L+++  + ++  ++G TPL +AA +GHVE V  L+ 
Sbjct: 502 DDQ----TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE 557

Query: 605 QGASILVKDYILKR--TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVL 662
           + AS   +  + K+  TP+H AA  G      LL+      NA      NG TPL ++V 
Sbjct: 558 KEAS---QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA---GKNGLTPLHVAVH 611

Query: 663 NGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTP 722
           + + D V  LL +G +  +    G T LH  A     E   +LLQ+G        +G TP
Sbjct: 612 HNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTP 671

Query: 723 IHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVF- 781
           +HL+A  GH  ++  LL    S  AN    +  G T LH     GH    ++L++  V  
Sbjct: 672 LHLAAQEGHAEMVALLL----SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV 727

Query: 782 QKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQL 841
             T    ++PLH A    N    + L+     + VNA    G +PLH AA   H + + L
Sbjct: 728 DATTRMGYTPLHVASHYGNIKLVKFLLQ--HQADVNAKTKLGYSPLHQAAQQGHTDIVTL 785

Query: 842 LLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875
           LL + A  N V S G TPL +A   G  +  ++L
Sbjct: 786 LLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819



 Score =  322 bits (826), Expect = 9e-88
 Identities = 250/784 (31%), Positives = 375/784 (47%), Gaps = 33/784 (4%)

Query: 180 AAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYG 239
           AA  G+++     + +G ++   ++     LH A+  G + +V  LL   + +      G
Sbjct: 52  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 111

Query: 240 NTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADV 299
           NT LH+A   GQD VV EL++ GA VN +++KGFTPL+ AA   H  + ++ L+ NGA+ 
Sbjct: 112 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV-VKFLLENGANQ 170

Query: 300 NMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLI 359
           N+ ++DG TPL +    G  +    +I  G     + K     LHIAAR         L+
Sbjct: 171 NVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTAAVLL 226

Query: 360 TSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLE 419
            +  +       G  PLH+AA     +  + LL+ G  ++     G T LH A+  GN+ 
Sbjct: 227 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVI 286

Query: 420 CLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAA 479
            + LLL+ GA    K K   +PLH AA N + +    L+  GA +    + G +P+H AA
Sbjct: 287 MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 346

Query: 480 TSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGT 539
             D    C+  LL+ DA            +H +A  GH    +++  +          G 
Sbjct: 347 QGD-HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK----------GA 395

Query: 540 DMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECV 599
              S + N  T  PLH+A    H + +E+L+++   +D    SG TPL +A+F GH+  V
Sbjct: 396 KPNSRALNGFT--PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 453

Query: 600 DVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLML 659
             L+ +GAS  V + +   TP+H AA  GH+E  + L+ N    NA    D   QTPL  
Sbjct: 454 KNLLQRGASPNVSN-VKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD---QTPLHC 509

Query: 660 SVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRG 719
           +   GHT+ V  LL   AN +     G T LH  A  GH E V ALL+  A       +G
Sbjct: 510 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 569

Query: 720 RTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQE 779
            TP+H++A  G + V   LL+     DA+P  A  +G T LH A ++ +   V+LLL + 
Sbjct: 570 FTPLHVAAKYGKVRVAELLLER----DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 625

Query: 780 VFQKTEG-NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVEC 838
               +   N ++PLH A   +    A  L+   G++  NA   +G TPLH AA   H E 
Sbjct: 626 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA--NAESVQGVTPLHLAAQEGHAEM 683

Query: 839 LQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLAC 898
           + LLLS  A  N  + +G TPL + A+ G     ++L+      +        T LH+A 
Sbjct: 684 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG-VMVDATTRMGYTPLHVAS 742

Query: 899 SKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDEN 958
             G+      +L+   D   +NA      +PLH AA+ G T +V  LL  GAS   V  +
Sbjct: 743 HYGNIKLVKFLLQHQAD---VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 799

Query: 959 GYTP 962
           G TP
Sbjct: 800 GTTP 803



 Score =  308 bits (790), Expect = 1e-83
 Identities = 233/767 (30%), Positives = 365/767 (47%), Gaps = 26/767 (3%)

Query: 11  SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
           S ++A  +G+ D+    +    D+N  +      LH A+  G  +++  L+     +   
Sbjct: 48  SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 107

Query: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
             K  T LH A  +  +E V+ L+ + A+VNA+ +   TPL++AA    ++  + L+   
Sbjct: 108 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 167

Query: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 190
           +N NV+   G T L  A   GH  +V  L++ G       K    A+H AA         
Sbjct: 168 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAA 223

Query: 191 LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 250
           +L+ +        K  +TPLH AA    ++V + LL+ G  +N     G TPLH+A   G
Sbjct: 224 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 283

Query: 251 QDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPL 310
             ++V  L+D GA +  K +   TPLH AA + H  +  E+L+ +GA +  K+K+G +P+
Sbjct: 284 NVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS-EILLDHGAPIQAKTKNGLSPI 342

Query: 311 HMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGI 370
           HM A        + ++Q  A ID    +  TPLH+AA  GH  +   L+  GA    R +
Sbjct: 343 HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 402

Query: 371 HGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGAD 430
           +G  PLH+A           LL +G  ID   + G T LH A+  G+L  +  LL  GA 
Sbjct: 403 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 462

Query: 431 FNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEY 490
            N  +    +PLH AA   + +    L+ + A VN   +   TPLH AA        ++ 
Sbjct: 463 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG-HTNMVKL 521

Query: 491 LLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRAT 550
           LL N+ANP +    G+  +H +A  GH         ET L +L + +    ++    +  
Sbjct: 522 LLENNANPNLATTAGHTPLHIAAREGH--------VETVLALLEKEASQACMT----KKG 569

Query: 551 ISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASIL 610
            +PLH+AA +G  +  E+L++     +    +G TPL +A    +++ V +L+ +G S  
Sbjct: 570 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 629

Query: 611 VKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVY 670
              +    TP+H AA     E  R L+      NA  +Q   G TPL L+   GH + V 
Sbjct: 630 SPAW-NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ---GVTPLHLAAQEGHAEMVA 685

Query: 671 SLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACG 730
            LL+K AN +  +K G T LH  A  GH    D L++HG         G TP+H+++  G
Sbjct: 686 LLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYG 745

Query: 731 HIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLE 777
           +I ++  LLQ  A ++A        GY+ LH A   GH   V LLL+
Sbjct: 746 NIKLVKFLLQHQADVNAKTKL----GYSPLHQAAQQGHTDIVTLLLK 788



 Score =  286 bits (731), Expect = 9e-77
 Identities = 214/720 (29%), Positives = 334/720 (46%), Gaps = 47/720 (6%)

Query: 15  AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 74
           A   G  + VR L+    +VN Q  +  TPL+ AA     E+++ L+ +GA  N      
Sbjct: 118 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 177

Query: 75  LTPL-----------------------------HRAVASCSEEAVQVLLKHSADVNARDK 105
            TPL                             H A  +       VLL++  + +   K
Sbjct: 178 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 237

Query: 106 NWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGAN 165
              TPLHIAA  + +  A+ L+   ++VN + + G T LH A+  G+  MV+LLL RGA 
Sbjct: 238 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 297

Query: 166 INAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYL 225
           I    K +   +H AA  GH+ + ++L+ HGA +  K K   +P+H AA    +  V+ L
Sbjct: 298 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 357

Query: 226 LDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHG 285
           L    ++++      TPLHVA + G   V   L+D GA  N +   GFTPLH A    H 
Sbjct: 358 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH- 416

Query: 286 ALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHI 345
              +ELL+  GA ++  ++ G TPLH+ +  G     + ++Q GA  +  +    TPLH+
Sbjct: 417 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 476

Query: 346 AARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFG 405
           AAR GH  +   L+ + A    +      PLH AA  G ++  + LL +  + +     G
Sbjct: 477 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 536

Query: 406 RTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVN 465
            T LH AA  G++E +  LL   A      K G +PLH AA     +    L+   A  N
Sbjct: 537 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 596

Query: 466 DLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIA 525
              + G TPLH  A    +   ++ LL    +P      GY  +H +A       +++  
Sbjct: 597 AAGKNGLTPLH-VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ---VEVAR 652

Query: 526 SETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRT 585
           S      L++  G+   +++++   ++PLHLAA  GH + + +L+    + ++ N SG T
Sbjct: 653 S------LLQYGGS---ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLT 703

Query: 586 PLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNA 645
           PL L A +GHV   DVLI  G  +      +  TP+H A+  G+ + ++ L+   + Q  
Sbjct: 704 PLHLVAQEGHVPVADVLIKHGVMVDATTR-MGYTPLHVASHYGNIKLVKFLL---QHQAD 759

Query: 646 VDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDAL 705
           V+ +   G +PL  +   GHTD V  LL  GA+ +     G T L      G+    D L
Sbjct: 760 VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819



 Score =  273 bits (699), Expect = 5e-73
 Identities = 192/600 (32%), Positives = 290/600 (48%), Gaps = 16/600 (2%)

Query: 10  PSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNA 69
           P+L  A  N D      L+    + +       TPLH AA+  +  + +LL+  GA VN 
Sbjct: 208 PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 267

Query: 70  KDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPL 129
                +TPLH A    +   V++LL   A +  + K+  TPLH AA N  V+ +E L+  
Sbjct: 268 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 327

Query: 130 LSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVV 189
            + +    + G + +H AA   H + V+LLL   A I+         +H AA+ GH  V 
Sbjct: 328 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 387

Query: 190 KLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYN 249
           K+L+  GA+   +    +TPLH A     + V++ LL  G  ++     G TPLHVA + 
Sbjct: 388 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 447

Query: 250 GQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTP 309
           G   +V  L+  GA  N  N K  TPLH AA + H  +  + L+ N A VN K+KD +TP
Sbjct: 448 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA-KYLLQNKAKVNAKAKDDQTP 506

Query: 310 LHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRG 369
           LH  A  G  +  + ++++ A  +     G+TPLHIAAR GH   +  L+   A  A   
Sbjct: 507 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 566

Query: 370 IHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGA 429
             G  PLH+AA  G       LL      +     G T LH A    NL+ + LLL  G 
Sbjct: 567 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 626

Query: 430 DFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLE 489
             +     G +PLH AA     +   +L+  G S N    +G TPLH AA  +   + + 
Sbjct: 627 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA-QEGHAEMVA 685

Query: 490 YLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPL-DVLMETSGTDMLSDSDNR 548
            LL   AN  + +K G   +H  A  GH           P+ DVL++     ++ D+  R
Sbjct: 686 LLLSKQANGNLGNKSGLTPLHLVAQEGH----------VPVADVLIKHG---VMVDATTR 732

Query: 549 ATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGAS 608
              +PLH+A+++G+ + ++ L+Q   D++ +   G +PL  AA +GH + V +L+  GAS
Sbjct: 733 MGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGAS 792



 Score =  259 bits (662), Expect = 9e-69
 Identities = 181/590 (30%), Positives = 280/590 (47%), Gaps = 17/590 (2%)

Query: 27  LIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCS 86
           L+ +   VNF      TPLH A+  G+  ++ LL+  GA++  K    LTPLH A  +  
Sbjct: 258 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 317

Query: 87  EEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHH 146
               ++LL H A + A+ KN  +P+H+AA    + C   L+   + ++       T LH 
Sbjct: 318 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHV 377

Query: 147 AAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS 206
           AA  GH  + K+LL +GA  N+        +H A    H+ V++LL+  GA +    +  
Sbjct: 378 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 437

Query: 207 YTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVN 266
            TPLH A+  G + +VK LL  G   N  N    TPLH+A   G   V   L+   A VN
Sbjct: 438 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 497

Query: 267 QKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTII 326
            K +   TPLH AA   H  + ++LL+ N A+ N+ +  G TPLH+ A  G       ++
Sbjct: 498 AKAKDDQTPLHCAARIGHTNM-VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 556

Query: 327 QSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSD 386
           +  A   C  K G TPLH+AA+YG   +   L+   A     G +G+ PLH+A      D
Sbjct: 557 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD 616

Query: 387 CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446
             + LL  G    +P   G T LH AA    +E    LL  G   N +   G +PLH AA
Sbjct: 617 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 676

Query: 447 ANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGY 506
              + + +  L+   A+ N  ++ G TPLH  A  +      + L+++        + GY
Sbjct: 677 QEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA-QEGHVPVADVLIKHGVMVDATTRMGY 735

Query: 507 NAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQAL 566
             +H ++ YG+   ++ +  +   DV  +T           +   SPLH AA  GH   +
Sbjct: 736 TPLHVASHYGNIKLVKFLL-QHQADVNAKT-----------KLGYSPLHQAAQQGHTDIV 783

Query: 567 EVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL---INQGASILVKD 613
            +L+++    +  +S G TPL +A   G++   DVL    ++ + +LV D
Sbjct: 784 TLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 833



 Score =  233 bits (595), Expect = 5e-61
 Identities = 192/636 (30%), Positives = 291/636 (45%), Gaps = 34/636 (5%)

Query: 346 AARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFG 405
           AAR G+       + +G D      +G+  LHLA+  G      +LL     ++T    G
Sbjct: 52  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 111

Query: 406 RTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVN 465
            T LH AA  G  E +  L+N GA+ N + + G +PL+ AA   + + +  L+ +GA+ N
Sbjct: 112 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 171

Query: 466 DLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGH-RLCLQLI 524
              E G TPL  A          E ++ +  N G + K    A+H +A     R    L+
Sbjct: 172 VATEDGFTPLAVALQQGH-----ENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLL 226

Query: 525 ASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGR 584
            ++   DVL +T  T             PLH+AA++ +    ++L+     ++    +G 
Sbjct: 227 QNDPNPDVLSKTGFT-------------PLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 273

Query: 585 TPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQN 644
           TPL +A+ +G+V  V +L+++GA I  K    + TP+H AA NGH     +L+ +  P  
Sbjct: 274 TPLHIASRRGNVIMVRLLLDRGAQIETKTKD-ELTPLHCAARNGHVRISEILLDHGAP-- 330

Query: 645 AVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDA 704
            +  +  NG +P+ ++    H DCV  LL   A +D       T LH  A  GH      
Sbjct: 331 -IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 389

Query: 705 LLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWAC 764
           LL  GAK   R   G TP+H++    H+ V+  LL++ AS+DA        G T LH A 
Sbjct: 390 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA----VTESGLTPLHVAS 445

Query: 765 YNGHETCVELLLEQEVFQKTEG-NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKG 823
           + GH   V+ LL++            +PLH A    +   A+ L+       VNA     
Sbjct: 446 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK--VNAKAKDD 503

Query: 824 RTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAEL 883
           +TPLH AA   H   ++LLL +NA  N   + G TPL +AA  G   TV  L+   +++ 
Sbjct: 504 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 563

Query: 884 TLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQ 943
            +      T LH+A   G    A L+LE+    N          TPLHVA  +    +V+
Sbjct: 564 CMTKKGF-TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL---TPLHVAVHHNNLDIVK 619

Query: 944 ELLGKGASVLAVDENGYTPALACAPNKDVADCLALI 979
            LL +G S  +   NGYTP    A    V    +L+
Sbjct: 620 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 655



 Score =  149 bits (377), Expect = 1e-35
 Identities = 107/313 (34%), Positives = 145/313 (46%), Gaps = 1/313 (0%)

Query: 8   DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
           DQ  L  A   G  + V+ L+    + N       TPLH AA  G  E +  L+   A  
Sbjct: 503 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 562

Query: 68  NAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALV 127
                K  TPLH A         ++LL+  A  NA  KN  TPLH+A  +  +   + L+
Sbjct: 563 ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 622

Query: 128 PLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIE 187
           P   + +     G T LH AA     E+ + LL  G + NA   +    +H AA  GH E
Sbjct: 623 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 682

Query: 188 VVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVAC 247
           +V LL+S  A     +K   TPLH  A  G + V   L+  GV ++     G TPLHVA 
Sbjct: 683 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 742

Query: 248 YNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGK 307
           + G   +V  L+   A VN K + G++PLH AA   H  + + LL+ NGA  N  S DG 
Sbjct: 743 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI-VTLLLKNGASPNEVSSDGT 801

Query: 308 TPLHMTALHGRFS 320
           TPL +    G  S
Sbjct: 802 TPLAIAKRLGYIS 814



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 33/110 (30%), Positives = 51/110 (46%), Gaps = 4/110 (3%)

Query: 858 TPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRN 917
           T  + AA +G  +     + +     T   N  N  LHLA  +GH     +++E +    
Sbjct: 47  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLN-GLHLASKEGH---VKMVVELLHKEI 102

Query: 918 LINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACA 967
           ++  T     T LH+AA  G   VV+EL+  GA+V A  + G+TP    A
Sbjct: 103 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 152


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  327 bits (839), Expect = 3e-89
 Identities = 248/812 (30%), Positives = 388/812 (47%), Gaps = 33/812 (4%)

Query: 67  VNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126
           V  +++   T   RA  S + +     L++  D+N  ++N    LH+A+    VK    L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHI 186
           +     +  + + G TALH AA +G  E+V+ L++ GAN+NA  +K    ++ AA   H+
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 187 EVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVA 246
           EVVK L+ +GA      +  +TPL  A   G  +VV +L++ G             LH+A
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIA 180

Query: 247 CYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDG 306
             N        L+      +  ++ GFTPLH  AA        +LL+  GA VN   ++G
Sbjct: 181 ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI-AAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 307 KTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTA 366
            TPLH+ +  G     + ++  GA I+ + K+  TPLH AAR GH  +   L+  GA   
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299

Query: 367 KRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLN 426
            +  +G+ P+H+AA     DC R LL    +ID       T LH AA  G+     +LL+
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359

Query: 427 TGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGK 486
            GA  N +   G +PLH A    + + +  L+ +GAS++ + E G TPLH A+       
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMG-HLP 418

Query: 487 CLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSD 546
            ++ LL+  A+P + + +    +H +A  GH        +E    +L   +  +  +  D
Sbjct: 419 IVKNLLQRGASPNVSNVKVETPLHMAARAGH--------TEVAKYLLQNKAKVNAKAKDD 470

Query: 547 NRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQG 606
                +PLH AA  GH   +++L+++  + ++  ++G TPL +AA +GHVE V  L+ + 
Sbjct: 471 Q----TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526

Query: 607 ASILVKDYILKR--TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNG 664
           AS   +  + K+  TP+H AA  G      LL+      NA      NG TPL ++V + 
Sbjct: 527 AS---QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA---GKNGLTPLHVAVHHN 580

Query: 665 HTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIH 724
           + D V  LL +G +  +    G T LH  A     E   +LLQ+G        +G TP+H
Sbjct: 581 NLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLH 640

Query: 725 LSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVF-QK 783
           L+A  GH  ++  LL    S  AN    +  G T LH     GH    ++L++  V    
Sbjct: 641 LAAQEGHAEMVALLL----SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696

Query: 784 TEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLL 843
           T    ++PLH A    N    + L+     + VNA    G +PLH AA   H + + LLL
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQ--HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754

Query: 844 SHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875
            + A  N V S G TPL +A   G  +  ++L
Sbjct: 755 KNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  322 bits (826), Expect = 9e-88
 Identities = 250/784 (31%), Positives = 375/784 (47%), Gaps = 33/784 (4%)

Query: 180 AAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYG 239
           AA  G+++     + +G ++   ++     LH A+  G + +V  LL   + +      G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 240 NTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADV 299
           NT LH+A   GQD VV EL++ GA VN +++KGFTPL+ AA   H  + ++ L+ NGA+ 
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV-VKFLLENGANQ 137

Query: 300 NMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLI 359
           N+ ++DG TPL +    G  +    +I  G     + K     LHIAAR         L+
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTAAVLL 193

Query: 360 TSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLE 419
            +  +       G  PLH+AA     +  + LL+ G  ++     G T LH A+  GN+ 
Sbjct: 194 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVI 253

Query: 420 CLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAA 479
            + LLL+ GA    K K   +PLH AA N + +    L+  GA +    + G +P+H AA
Sbjct: 254 MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 313

Query: 480 TSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGT 539
             D    C+  LL+ DA            +H +A  GH    +++  +          G 
Sbjct: 314 QGD-HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK----------GA 362

Query: 540 DMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECV 599
              S + N  T  PLH+A    H + +E+L+++   +D    SG TPL +A+F GH+  V
Sbjct: 363 KPNSRALNGFT--PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420

Query: 600 DVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLML 659
             L+ +GAS  V + +   TP+H AA  GH+E  + L+ N    NA    D   QTPL  
Sbjct: 421 KNLLQRGASPNVSN-VKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD---QTPLHC 476

Query: 660 SVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRG 719
           +   GHT+ V  LL   AN +     G T LH  A  GH E V ALL+  A       +G
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 720 RTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQE 779
            TP+H++A  G + V   LL+     DA+P  A  +G T LH A ++ +   V+LLL + 
Sbjct: 537 FTPLHVAAKYGKVRVAELLLER----DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592

Query: 780 VFQKTEG-NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVEC 838
               +   N ++PLH A   +    A  L+   G++  NA   +G TPLH AA   H E 
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA--NAESVQGVTPLHLAAQEGHAEM 650

Query: 839 LQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLAC 898
           + LLLS  A  N  + +G TPL + A+ G     ++L+      +        T LH+A 
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG-VMVDATTRMGYTPLHVAS 709

Query: 899 SKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDEN 958
             G+      +L+   D   +NA      +PLH AA+ G T +V  LL  GAS   V  +
Sbjct: 710 HYGNIKLVKFLLQHQAD---VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766

Query: 959 GYTP 962
           G TP
Sbjct: 767 GTTP 770



 Score =  308 bits (790), Expect = 1e-83
 Identities = 233/767 (30%), Positives = 365/767 (47%), Gaps = 26/767 (3%)

Query: 11  SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
           S ++A  +G+ D+    +    D+N  +      LH A+  G  +++  L+     +   
Sbjct: 15  SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74

Query: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
             K  T LH A  +  +E V+ L+ + A+VNA+ +   TPL++AA    ++  + L+   
Sbjct: 75  TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134

Query: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 190
           +N NV+   G T L  A   GH  +V  L++ G       K    A+H AA         
Sbjct: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAA 190

Query: 191 LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 250
           +L+ +        K  +TPLH AA    ++V + LL+ G  +N     G TPLH+A   G
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250

Query: 251 QDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPL 310
             ++V  L+D GA +  K +   TPLH AA + H  +  E+L+ +GA +  K+K+G +P+
Sbjct: 251 NVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS-EILLDHGAPIQAKTKNGLSPI 309

Query: 311 HMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGI 370
           HM A        + ++Q  A ID    +  TPLH+AA  GH  +   L+  GA    R +
Sbjct: 310 HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369

Query: 371 HGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGAD 430
           +G  PLH+A           LL +G  ID   + G T LH A+  G+L  +  LL  GA 
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429

Query: 431 FNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEY 490
            N  +    +PLH AA   + +    L+ + A VN   +   TPLH AA        ++ 
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG-HTNMVKL 488

Query: 491 LLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRAT 550
           LL N+ANP +    G+  +H +A  GH         ET L +L + +    ++    +  
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGH--------VETVLALLEKEASQACMT----KKG 536

Query: 551 ISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASIL 610
            +PLH+AA +G  +  E+L++     +    +G TPL +A    +++ V +L+ +G S  
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596

Query: 611 VKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVY 670
              +    TP+H AA     E  R L+      NA  +Q   G TPL L+   GH + V 
Sbjct: 597 SPAW-NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ---GVTPLHLAAQEGHAEMVA 652

Query: 671 SLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACG 730
            LL+K AN +  +K G T LH  A  GH    D L++HG         G TP+H+++  G
Sbjct: 653 LLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYG 712

Query: 731 HIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLE 777
           +I ++  LLQ  A ++A        GY+ LH A   GH   V LLL+
Sbjct: 713 NIKLVKFLLQHQADVNAKTKL----GYSPLHQAAQQGHTDIVTLLLK 755



 Score =  296 bits (758), Expect = 7e-80
 Identities = 243/833 (29%), Positives = 372/833 (44%), Gaps = 40/833 (4%)

Query: 132 NVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKL 191
           +V   +    T+   AA SG+ +     L  G +IN  ++     +H A+  GH+++V  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 192 LVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQ 251
           L+     +    KK  T LH AA +G   VV+ L++ G ++N  +  G TPL++A     
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 252 DVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLH 311
             VV  L++ GA  N   E GFTPL  A    H     E +V +  +   K K     LH
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGH-----ENVVAHLINYGTKGKVRLPALH 178

Query: 312 MTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIH 371
           + A +     +  ++Q+    D   K G TPLHIAA Y +  +   L+  GA       +
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238

Query: 372 GMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADF 431
           G+ PLH+A+  G     R LL  G  I+T      T LH AA  G++    +LL+ GA  
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298

Query: 432 NKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYL 491
             K K G SP+H AA   +  C+  L+   A ++D+     TPLH AA      +  + L
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG-HHRVAKVL 357

Query: 492 LRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATI 551
           L   A P  R   G+  +H +    H   ++L+              T    D+   + +
Sbjct: 358 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK------------TGASIDAVTESGL 405

Query: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611
           +PLH+A++ GH   ++ L+Q     +V N    TPL +AA  GH E    L+   A +  
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465

Query: 612 KDYILKRTPIHAAATNGHSECLRLLI-GNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVY 670
           K     +TP+H AA  GH+  ++LL+  NA P  A       G TPL ++   GH + V 
Sbjct: 466 KAKD-DQTPLHCAARIGHTNMVKLLLENNANPNLATTA----GHTPLHIAAREGHVETVL 520

Query: 671 SLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACG 730
           +LL K A+     K G T LH  A  G     + LL+  A        G TP+H++    
Sbjct: 521 ALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHN 580

Query: 731 HIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEG-NAF 789
           ++ ++  LL    S    P +   +GYT LH A           LL+       E     
Sbjct: 581 NLDIVKLLLPRGGS----PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV 636

Query: 790 SPLHCAVINDNEGAAEMLIDTLGASI-VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQ 848
           +PLH A     EG AEM+   L      N  +  G TPLH  A   HV    +L+ H   
Sbjct: 637 TPLHLAA---QEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693

Query: 849 VNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALL 908
           V++    G TPL +A+  G    V+ L+    A++  +     + LH A  +GH     L
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQH-QADVNAKTKLGYSPLHQAAQQGHTDIVTL 752

Query: 909 ILEKITDRNLINATNAALQTPLHVAARNG---LTMVVQELLGKGASVLAVDEN 958
           +L+     N +++      TPL +A R G   +T V++ +  + + VL  D++
Sbjct: 753 LLKNGASPNEVSSDGT---TPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKH 802



 Score =  286 bits (731), Expect = 9e-77
 Identities = 214/720 (29%), Positives = 334/720 (46%), Gaps = 47/720 (6%)

Query: 15  AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 74
           A   G  + VR L+    +VN Q  +  TPL+ AA     E+++ L+ +GA  N      
Sbjct: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144

Query: 75  LTPL-----------------------------HRAVASCSEEAVQVLLKHSADVNARDK 105
            TPL                             H A  +       VLL++  + +   K
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204

Query: 106 NWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGAN 165
              TPLHIAA  + +  A+ L+   ++VN + + G T LH A+  G+  MV+LLL RGA 
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264

Query: 166 INAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYL 225
           I    K +   +H AA  GH+ + ++L+ HGA +  K K   +P+H AA    +  V+ L
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324

Query: 226 LDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHG 285
           L    ++++      TPLHVA + G   V   L+D GA  N +   GFTPLH A    H 
Sbjct: 325 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH- 383

Query: 286 ALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHI 345
              +ELL+  GA ++  ++ G TPLH+ +  G     + ++Q GA  +  +    TPLH+
Sbjct: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443

Query: 346 AARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFG 405
           AAR GH  +   L+ + A    +      PLH AA  G ++  + LL +  + +     G
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503

Query: 406 RTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVN 465
            T LH AA  G++E +  LL   A      K G +PLH AA     +    L+   A  N
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563

Query: 466 DLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIA 525
              + G TPLH  A    +   ++ LL    +P      GY  +H +A       +++  
Sbjct: 564 AAGKNGLTPLH-VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ---VEVAR 619

Query: 526 SETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRT 585
           S      L++  G+   +++++   ++PLHLAA  GH + + +L+    + ++ N SG T
Sbjct: 620 S------LLQYGGS---ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLT 670

Query: 586 PLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNA 645
           PL L A +GHV   DVLI  G  +      +  TP+H A+  G+ + ++ L+   + Q  
Sbjct: 671 PLHLVAQEGHVPVADVLIKHGVMVDATTR-MGYTPLHVASHYGNIKLVKFLL---QHQAD 726

Query: 646 VDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDAL 705
           V+ +   G +PL  +   GHTD V  LL  GA+ +     G T L      G+    D L
Sbjct: 727 VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  273 bits (699), Expect = 5e-73
 Identities = 192/600 (32%), Positives = 290/600 (48%), Gaps = 16/600 (2%)

Query: 10  PSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNA 69
           P+L  A  N D      L+    + +       TPLH AA+  +  + +LL+  GA VN 
Sbjct: 175 PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234

Query: 70  KDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPL 129
                +TPLH A    +   V++LL   A +  + K+  TPLH AA N  V+ +E L+  
Sbjct: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294

Query: 130 LSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVV 189
            + +    + G + +H AA   H + V+LLL   A I+         +H AA+ GH  V 
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354

Query: 190 KLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYN 249
           K+L+  GA+   +    +TPLH A     + V++ LL  G  ++     G TPLHVA + 
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414

Query: 250 GQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTP 309
           G   +V  L+  GA  N  N K  TPLH AA + H  +  + L+ N A VN K+KD +TP
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA-KYLLQNKAKVNAKAKDDQTP 473

Query: 310 LHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRG 369
           LH  A  G  +  + ++++ A  +     G+TPLHIAAR GH   +  L+   A  A   
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533

Query: 370 IHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGA 429
             G  PLH+AA  G       LL      +     G T LH A    NL+ + LLL  G 
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593

Query: 430 DFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLE 489
             +     G +PLH AA     +   +L+  G S N    +G TPLH AA  +   + + 
Sbjct: 594 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA-QEGHAEMVA 652

Query: 490 YLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPL-DVLMETSGTDMLSDSDNR 548
            LL   AN  + +K G   +H  A  GH           P+ DVL++     ++ D+  R
Sbjct: 653 LLLSKQANGNLGNKSGLTPLHLVAQEGH----------VPVADVLIKHG---VMVDATTR 699

Query: 549 ATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGAS 608
              +PLH+A+++G+ + ++ L+Q   D++ +   G +PL  AA +GH + V +L+  GAS
Sbjct: 700 MGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGAS 759



 Score =  259 bits (662), Expect = 9e-69
 Identities = 181/590 (30%), Positives = 280/590 (47%), Gaps = 17/590 (2%)

Query: 27  LIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCS 86
           L+ +   VNF      TPLH A+  G+  ++ LL+  GA++  K    LTPLH A  +  
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 284

Query: 87  EEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHH 146
               ++LL H A + A+ KN  +P+H+AA    + C   L+   + ++       T LH 
Sbjct: 285 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHV 344

Query: 147 AAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS 206
           AA  GH  + K+LL +GA  N+        +H A    H+ V++LL+  GA +    +  
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404

Query: 207 YTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVN 266
            TPLH A+  G + +VK LL  G   N  N    TPLH+A   G   V   L+   A VN
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464

Query: 267 QKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTII 326
            K +   TPLH AA   H  + ++LL+ N A+ N+ +  G TPLH+ A  G       ++
Sbjct: 465 AKAKDDQTPLHCAARIGHTNM-VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523

Query: 327 QSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSD 386
           +  A   C  K G TPLH+AA+YG   +   L+   A     G +G+ PLH+A      D
Sbjct: 524 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD 583

Query: 387 CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446
             + LL  G    +P   G T LH AA    +E    LL  G   N +   G +PLH AA
Sbjct: 584 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643

Query: 447 ANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGY 506
              + + +  L+   A+ N  ++ G TPLH  A  +      + L+++        + GY
Sbjct: 644 QEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA-QEGHVPVADVLIKHGVMVDATTRMGY 702

Query: 507 NAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQAL 566
             +H ++ YG+   ++ +  +   DV  +T           +   SPLH AA  GH   +
Sbjct: 703 TPLHVASHYGNIKLVKFLL-QHQADVNAKT-----------KLGYSPLHQAAQQGHTDIV 750

Query: 567 EVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL---INQGASILVKD 613
            +L+++    +  +S G TPL +A   G++   DVL    ++ + +LV D
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 800



 Score =  233 bits (595), Expect = 5e-61
 Identities = 192/636 (30%), Positives = 291/636 (45%), Gaps = 34/636 (5%)

Query: 346 AARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFG 405
           AAR G+       + +G D      +G+  LHLA+  G      +LL     ++T    G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 406 RTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVN 465
            T LH AA  G  E +  L+N GA+ N + + G +PL+ AA   + + +  L+ +GA+ N
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138

Query: 466 DLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGH-RLCLQLI 524
              E G TPL  A          E ++ +  N G + K    A+H +A     R    L+
Sbjct: 139 VATEDGFTPLAVALQQGH-----ENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLL 193

Query: 525 ASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGR 584
            ++   DVL +T  T             PLH+AA++ +    ++L+     ++    +G 
Sbjct: 194 QNDPNPDVLSKTGFT-------------PLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 240

Query: 585 TPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQN 644
           TPL +A+ +G+V  V +L+++GA I  K    + TP+H AA NGH     +L+ +  P  
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKD-ELTPLHCAARNGHVRISEILLDHGAP-- 297

Query: 645 AVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDA 704
            +  +  NG +P+ ++    H DCV  LL   A +D       T LH  A  GH      
Sbjct: 298 -IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 356

Query: 705 LLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWAC 764
           LL  GAK   R   G TP+H++    H+ V+  LL++ AS+DA        G T LH A 
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA----VTESGLTPLHVAS 412

Query: 765 YNGHETCVELLLEQEVFQKTEG-NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKG 823
           + GH   V+ LL++            +PLH A    +   A+ L+       VNA     
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK--VNAKAKDD 470

Query: 824 RTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAEL 883
           +TPLH AA   H   ++LLL +NA  N   + G TPL +AA  G   TV  L+   +++ 
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 884 TLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQ 943
            +      T LH+A   G    A L+LE+    N          TPLHVA  +    +V+
Sbjct: 531 CMTKKGF-TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL---TPLHVAVHHNNLDIVK 586

Query: 944 ELLGKGASVLAVDENGYTPALACAPNKDVADCLALI 979
            LL +G S  +   NGYTP    A    V    +L+
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622



 Score =  149 bits (377), Expect = 1e-35
 Identities = 107/313 (34%), Positives = 145/313 (46%), Gaps = 1/313 (0%)

Query: 8   DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
           DQ  L  A   G  + V+ L+    + N       TPLH AA  G  E +  L+   A  
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529

Query: 68  NAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALV 127
                K  TPLH A         ++LL+  A  NA  KN  TPLH+A  +  +   + L+
Sbjct: 530 ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589

Query: 128 PLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIE 187
           P   + +     G T LH AA     E+ + LL  G + NA   +    +H AA  GH E
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649

Query: 188 VVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVAC 247
           +V LL+S  A     +K   TPLH  A  G + V   L+  GV ++     G TPLHVA 
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709

Query: 248 YNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGK 307
           + G   +V  L+   A VN K + G++PLH AA   H  + + LL+ NGA  N  S DG 
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI-VTLLLKNGASPNEVSSDGT 768

Query: 308 TPLHMTALHGRFS 320
           TPL +    G  S
Sbjct: 769 TPLAIAKRLGYIS 781



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 33/115 (28%), Positives = 53/115 (46%), Gaps = 4/115 (3%)

Query: 853 DSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEK 912
           ++   T  + AA +G  +     + +     T   N  N  LHLA  +GH     +++E 
Sbjct: 9   EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLN-GLHLASKEGH---VKMVVEL 64

Query: 913 ITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACA 967
           +    ++  T     T LH+AA  G   VV+EL+  GA+V A  + G+TP    A
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 119


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  327 bits (839), Expect = 3e-89
 Identities = 248/812 (30%), Positives = 388/812 (47%), Gaps = 33/812 (4%)

Query: 67  VNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126
           V  +++   T   RA  S + +     L++  D+N  ++N    LH+A+    VK    L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHI 186
           +     +  + + G TALH AA +G  E+V+ L++ GAN+NA  +K    ++ AA   H+
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 187 EVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVA 246
           EVVK L+ +GA      +  +TPL  A   G  +VV +L++ G             LH+A
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIA 180

Query: 247 CYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDG 306
             N        L+      +  ++ GFTPLH  AA        +LL+  GA VN   ++G
Sbjct: 181 ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI-AAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 307 KTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTA 366
            TPLH+ +  G     + ++  GA I+ + K+  TPLH AAR GH  +   L+  GA   
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299

Query: 367 KRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLN 426
            +  +G+ P+H+AA     DC R LL    +ID       T LH AA  G+     +LL+
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359

Query: 427 TGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGK 486
            GA  N +   G +PLH A    + + +  L+ +GAS++ + E G TPLH A+       
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMG-HLP 418

Query: 487 CLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSD 546
            ++ LL+  A+P + + +    +H +A  GH        +E    +L   +  +  +  D
Sbjct: 419 IVKNLLQRGASPNVSNVKVETPLHMAARAGH--------TEVAKYLLQNKAKVNAKAKDD 470

Query: 547 NRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQG 606
                +PLH AA  GH   +++L+++  + ++  ++G TPL +AA +GHVE V  L+ + 
Sbjct: 471 Q----TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526

Query: 607 ASILVKDYILKR--TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNG 664
           AS   +  + K+  TP+H AA  G      LL+      NA      NG TPL ++V + 
Sbjct: 527 AS---QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA---GKNGLTPLHVAVHHN 580

Query: 665 HTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIH 724
           + D V  LL +G +  +    G T LH  A     E   +LLQ+G        +G TP+H
Sbjct: 581 NLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLH 640

Query: 725 LSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVF-QK 783
           L+A  GH  ++  LL    S  AN    +  G T LH     GH    ++L++  V    
Sbjct: 641 LAAQEGHAEMVALLL----SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696

Query: 784 TEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLL 843
           T    ++PLH A    N    + L+     + VNA    G +PLH AA   H + + LLL
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQ--HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754

Query: 844 SHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875
            + A  N V S G TPL +A   G  +  ++L
Sbjct: 755 KNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  322 bits (826), Expect = 9e-88
 Identities = 250/784 (31%), Positives = 375/784 (47%), Gaps = 33/784 (4%)

Query: 180 AAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYG 239
           AA  G+++     + +G ++   ++     LH A+  G + +V  LL   + +      G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 240 NTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADV 299
           NT LH+A   GQD VV EL++ GA VN +++KGFTPL+ AA   H  + ++ L+ NGA+ 
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV-VKFLLENGANQ 137

Query: 300 NMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLI 359
           N+ ++DG TPL +    G  +    +I  G     + K     LHIAAR         L+
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTAAVLL 193

Query: 360 TSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLE 419
            +  +       G  PLH+AA     +  + LL+ G  ++     G T LH A+  GN+ 
Sbjct: 194 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVI 253

Query: 420 CLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAA 479
            + LLL+ GA    K K   +PLH AA N + +    L+  GA +    + G +P+H AA
Sbjct: 254 MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 313

Query: 480 TSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGT 539
             D    C+  LL+ DA            +H +A  GH    +++  +          G 
Sbjct: 314 QGD-HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK----------GA 362

Query: 540 DMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECV 599
              S + N  T  PLH+A    H + +E+L+++   +D    SG TPL +A+F GH+  V
Sbjct: 363 KPNSRALNGFT--PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420

Query: 600 DVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLML 659
             L+ +GAS  V + +   TP+H AA  GH+E  + L+ N    NA    D   QTPL  
Sbjct: 421 KNLLQRGASPNVSN-VKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD---QTPLHC 476

Query: 660 SVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRG 719
           +   GHT+ V  LL   AN +     G T LH  A  GH E V ALL+  A       +G
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 720 RTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQE 779
            TP+H++A  G + V   LL+     DA+P  A  +G T LH A ++ +   V+LLL + 
Sbjct: 537 FTPLHVAAKYGKVRVAELLLER----DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592

Query: 780 VFQKTEG-NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVEC 838
               +   N ++PLH A   +    A  L+   G++  NA   +G TPLH AA   H E 
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA--NAESVQGVTPLHLAAQEGHAEM 650

Query: 839 LQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLAC 898
           + LLLS  A  N  + +G TPL + A+ G     ++L+      +        T LH+A 
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG-VMVDATTRMGYTPLHVAS 709

Query: 899 SKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDEN 958
             G+      +L+   D   +NA      +PLH AA+ G T +V  LL  GAS   V  +
Sbjct: 710 HYGNIKLVKFLLQHQAD---VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766

Query: 959 GYTP 962
           G TP
Sbjct: 767 GTTP 770



 Score =  308 bits (790), Expect = 1e-83
 Identities = 233/767 (30%), Positives = 365/767 (47%), Gaps = 26/767 (3%)

Query: 11  SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
           S ++A  +G+ D+    +    D+N  +      LH A+  G  +++  L+     +   
Sbjct: 15  SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74

Query: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
             K  T LH A  +  +E V+ L+ + A+VNA+ +   TPL++AA    ++  + L+   
Sbjct: 75  TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134

Query: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 190
           +N NV+   G T L  A   GH  +V  L++ G       K    A+H AA         
Sbjct: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAA 190

Query: 191 LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 250
           +L+ +        K  +TPLH AA    ++V + LL+ G  +N     G TPLH+A   G
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250

Query: 251 QDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPL 310
             ++V  L+D GA +  K +   TPLH AA + H  +  E+L+ +GA +  K+K+G +P+
Sbjct: 251 NVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS-EILLDHGAPIQAKTKNGLSPI 309

Query: 311 HMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGI 370
           HM A        + ++Q  A ID    +  TPLH+AA  GH  +   L+  GA    R +
Sbjct: 310 HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369

Query: 371 HGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGAD 430
           +G  PLH+A           LL +G  ID   + G T LH A+  G+L  +  LL  GA 
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429

Query: 431 FNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEY 490
            N  +    +PLH AA   + +    L+ + A VN   +   TPLH AA        ++ 
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG-HTNMVKL 488

Query: 491 LLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRAT 550
           LL N+ANP +    G+  +H +A  GH         ET L +L + +    ++    +  
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGH--------VETVLALLEKEASQACMT----KKG 536

Query: 551 ISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASIL 610
            +PLH+AA +G  +  E+L++     +    +G TPL +A    +++ V +L+ +G S  
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596

Query: 611 VKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVY 670
              +    TP+H AA     E  R L+      NA  +Q   G TPL L+   GH + V 
Sbjct: 597 SPAW-NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ---GVTPLHLAAQEGHAEMVA 652

Query: 671 SLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACG 730
            LL+K AN +  +K G T LH  A  GH    D L++HG         G TP+H+++  G
Sbjct: 653 LLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYG 712

Query: 731 HIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLE 777
           +I ++  LLQ  A ++A        GY+ LH A   GH   V LLL+
Sbjct: 713 NIKLVKFLLQHQADVNAKTKL----GYSPLHQAAQQGHTDIVTLLLK 755



 Score =  296 bits (758), Expect = 7e-80
 Identities = 243/833 (29%), Positives = 372/833 (44%), Gaps = 40/833 (4%)

Query: 132 NVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKL 191
           +V   +    T+   AA SG+ +     L  G +IN  ++     +H A+  GH+++V  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 192 LVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQ 251
           L+     +    KK  T LH AA +G   VV+ L++ G ++N  +  G TPL++A     
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 252 DVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLH 311
             VV  L++ GA  N   E GFTPL  A    H     E +V +  +   K K     LH
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGH-----ENVVAHLINYGTKGKVRLPALH 178

Query: 312 MTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIH 371
           + A +     +  ++Q+    D   K G TPLHIAA Y +  +   L+  GA       +
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238

Query: 372 GMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADF 431
           G+ PLH+A+  G     R LL  G  I+T      T LH AA  G++    +LL+ GA  
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298

Query: 432 NKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYL 491
             K K G SP+H AA   +  C+  L+   A ++D+     TPLH AA      +  + L
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG-HHRVAKVL 357

Query: 492 LRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATI 551
           L   A P  R   G+  +H +    H   ++L+              T    D+   + +
Sbjct: 358 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK------------TGASIDAVTESGL 405

Query: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611
           +PLH+A++ GH   ++ L+Q     +V N    TPL +AA  GH E    L+   A +  
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465

Query: 612 KDYILKRTPIHAAATNGHSECLRLLI-GNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVY 670
           K     +TP+H AA  GH+  ++LL+  NA P  A       G TPL ++   GH + V 
Sbjct: 466 KAKD-DQTPLHCAARIGHTNMVKLLLENNANPNLATTA----GHTPLHIAAREGHVETVL 520

Query: 671 SLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACG 730
           +LL K A+     K G T LH  A  G     + LL+  A        G TP+H++    
Sbjct: 521 ALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHN 580

Query: 731 HIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEG-NAF 789
           ++ ++  LL    S    P +   +GYT LH A           LL+       E     
Sbjct: 581 NLDIVKLLLPRGGS----PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV 636

Query: 790 SPLHCAVINDNEGAAEMLIDTLGASI-VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQ 848
           +PLH A     EG AEM+   L      N  +  G TPLH  A   HV    +L+ H   
Sbjct: 637 TPLHLAA---QEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693

Query: 849 VNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALL 908
           V++    G TPL +A+  G    V+ L+    A++  +     + LH A  +GH     L
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQH-QADVNAKTKLGYSPLHQAAQQGHTDIVTL 752

Query: 909 ILEKITDRNLINATNAALQTPLHVAARNG---LTMVVQELLGKGASVLAVDEN 958
           +L+     N +++      TPL +A R G   +T V++ +  + + VL  D++
Sbjct: 753 LLKNGASPNEVSSDGT---TPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKH 802



 Score =  286 bits (731), Expect = 9e-77
 Identities = 214/720 (29%), Positives = 334/720 (46%), Gaps = 47/720 (6%)

Query: 15  AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 74
           A   G  + VR L+    +VN Q  +  TPL+ AA     E+++ L+ +GA  N      
Sbjct: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144

Query: 75  LTPL-----------------------------HRAVASCSEEAVQVLLKHSADVNARDK 105
            TPL                             H A  +       VLL++  + +   K
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204

Query: 106 NWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGAN 165
              TPLHIAA  + +  A+ L+   ++VN + + G T LH A+  G+  MV+LLL RGA 
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264

Query: 166 INAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYL 225
           I    K +   +H AA  GH+ + ++L+ HGA +  K K   +P+H AA    +  V+ L
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324

Query: 226 LDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHG 285
           L    ++++      TPLHVA + G   V   L+D GA  N +   GFTPLH A    H 
Sbjct: 325 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH- 383

Query: 286 ALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHI 345
              +ELL+  GA ++  ++ G TPLH+ +  G     + ++Q GA  +  +    TPLH+
Sbjct: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443

Query: 346 AARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFG 405
           AAR GH  +   L+ + A    +      PLH AA  G ++  + LL +  + +     G
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503

Query: 406 RTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVN 465
            T LH AA  G++E +  LL   A      K G +PLH AA     +    L+   A  N
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563

Query: 466 DLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIA 525
              + G TPLH  A    +   ++ LL    +P      GY  +H +A       +++  
Sbjct: 564 AAGKNGLTPLH-VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ---VEVAR 619

Query: 526 SETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRT 585
           S      L++  G+   +++++   ++PLHLAA  GH + + +L+    + ++ N SG T
Sbjct: 620 S------LLQYGGS---ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLT 670

Query: 586 PLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNA 645
           PL L A +GHV   DVLI  G  +      +  TP+H A+  G+ + ++ L+   + Q  
Sbjct: 671 PLHLVAQEGHVPVADVLIKHGVMVDATTR-MGYTPLHVASHYGNIKLVKFLL---QHQAD 726

Query: 646 VDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDAL 705
           V+ +   G +PL  +   GHTD V  LL  GA+ +     G T L      G+    D L
Sbjct: 727 VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  273 bits (699), Expect = 5e-73
 Identities = 192/600 (32%), Positives = 290/600 (48%), Gaps = 16/600 (2%)

Query: 10  PSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNA 69
           P+L  A  N D      L+    + +       TPLH AA+  +  + +LL+  GA VN 
Sbjct: 175 PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234

Query: 70  KDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPL 129
                +TPLH A    +   V++LL   A +  + K+  TPLH AA N  V+ +E L+  
Sbjct: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294

Query: 130 LSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVV 189
            + +    + G + +H AA   H + V+LLL   A I+         +H AA+ GH  V 
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354

Query: 190 KLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYN 249
           K+L+  GA+   +    +TPLH A     + V++ LL  G  ++     G TPLHVA + 
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414

Query: 250 GQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTP 309
           G   +V  L+  GA  N  N K  TPLH AA + H  +  + L+ N A VN K+KD +TP
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA-KYLLQNKAKVNAKAKDDQTP 473

Query: 310 LHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRG 369
           LH  A  G  +  + ++++ A  +     G+TPLHIAAR GH   +  L+   A  A   
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533

Query: 370 IHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGA 429
             G  PLH+AA  G       LL      +     G T LH A    NL+ + LLL  G 
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593

Query: 430 DFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLE 489
             +     G +PLH AA     +   +L+  G S N    +G TPLH AA  +   + + 
Sbjct: 594 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA-QEGHAEMVA 652

Query: 490 YLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPL-DVLMETSGTDMLSDSDNR 548
            LL   AN  + +K G   +H  A  GH           P+ DVL++     ++ D+  R
Sbjct: 653 LLLSKQANGNLGNKSGLTPLHLVAQEGH----------VPVADVLIKHG---VMVDATTR 699

Query: 549 ATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGAS 608
              +PLH+A+++G+ + ++ L+Q   D++ +   G +PL  AA +GH + V +L+  GAS
Sbjct: 700 MGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGAS 759



 Score =  259 bits (662), Expect = 9e-69
 Identities = 181/590 (30%), Positives = 280/590 (47%), Gaps = 17/590 (2%)

Query: 27  LIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCS 86
           L+ +   VNF      TPLH A+  G+  ++ LL+  GA++  K    LTPLH A  +  
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 284

Query: 87  EEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHH 146
               ++LL H A + A+ KN  +P+H+AA    + C   L+   + ++       T LH 
Sbjct: 285 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHV 344

Query: 147 AAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS 206
           AA  GH  + K+LL +GA  N+        +H A    H+ V++LL+  GA +    +  
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404

Query: 207 YTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVN 266
            TPLH A+  G + +VK LL  G   N  N    TPLH+A   G   V   L+   A VN
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464

Query: 267 QKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTII 326
            K +   TPLH AA   H  + ++LL+ N A+ N+ +  G TPLH+ A  G       ++
Sbjct: 465 AKAKDDQTPLHCAARIGHTNM-VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523

Query: 327 QSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSD 386
           +  A   C  K G TPLH+AA+YG   +   L+   A     G +G+ PLH+A      D
Sbjct: 524 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD 583

Query: 387 CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446
             + LL  G    +P   G T LH AA    +E    LL  G   N +   G +PLH AA
Sbjct: 584 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643

Query: 447 ANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGY 506
              + + +  L+   A+ N  ++ G TPLH  A  +      + L+++        + GY
Sbjct: 644 QEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA-QEGHVPVADVLIKHGVMVDATTRMGY 702

Query: 507 NAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQAL 566
             +H ++ YG+   ++ +  +   DV  +T           +   SPLH AA  GH   +
Sbjct: 703 TPLHVASHYGNIKLVKFLL-QHQADVNAKT-----------KLGYSPLHQAAQQGHTDIV 750

Query: 567 EVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL---INQGASILVKD 613
            +L+++    +  +S G TPL +A   G++   DVL    ++ + +LV D
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 800



 Score =  233 bits (595), Expect = 5e-61
 Identities = 192/636 (30%), Positives = 291/636 (45%), Gaps = 34/636 (5%)

Query: 346 AARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFG 405
           AAR G+       + +G D      +G+  LHLA+  G      +LL     ++T    G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 406 RTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVN 465
            T LH AA  G  E +  L+N GA+ N + + G +PL+ AA   + + +  L+ +GA+ N
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138

Query: 466 DLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGH-RLCLQLI 524
              E G TPL  A          E ++ +  N G + K    A+H +A     R    L+
Sbjct: 139 VATEDGFTPLAVALQQGH-----ENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLL 193

Query: 525 ASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGR 584
            ++   DVL +T  T             PLH+AA++ +    ++L+     ++    +G 
Sbjct: 194 QNDPNPDVLSKTGFT-------------PLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 240

Query: 585 TPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQN 644
           TPL +A+ +G+V  V +L+++GA I  K    + TP+H AA NGH     +L+ +  P  
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKD-ELTPLHCAARNGHVRISEILLDHGAP-- 297

Query: 645 AVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDA 704
            +  +  NG +P+ ++    H DCV  LL   A +D       T LH  A  GH      
Sbjct: 298 -IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 356

Query: 705 LLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWAC 764
           LL  GAK   R   G TP+H++    H+ V+  LL++ AS+DA        G T LH A 
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA----VTESGLTPLHVAS 412

Query: 765 YNGHETCVELLLEQEVFQKTEG-NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKG 823
           + GH   V+ LL++            +PLH A    +   A+ L+       VNA     
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK--VNAKAKDD 470

Query: 824 RTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAEL 883
           +TPLH AA   H   ++LLL +NA  N   + G TPL +AA  G   TV  L+   +++ 
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 884 TLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQ 943
            +      T LH+A   G    A L+LE+    N          TPLHVA  +    +V+
Sbjct: 531 CMTKKGF-TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL---TPLHVAVHHNNLDIVK 586

Query: 944 ELLGKGASVLAVDENGYTPALACAPNKDVADCLALI 979
            LL +G S  +   NGYTP    A    V    +L+
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622



 Score =  149 bits (377), Expect = 1e-35
 Identities = 107/313 (34%), Positives = 145/313 (46%), Gaps = 1/313 (0%)

Query: 8   DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
           DQ  L  A   G  + V+ L+    + N       TPLH AA  G  E +  L+   A  
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529

Query: 68  NAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALV 127
                K  TPLH A         ++LL+  A  NA  KN  TPLH+A  +  +   + L+
Sbjct: 530 ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589

Query: 128 PLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIE 187
           P   + +     G T LH AA     E+ + LL  G + NA   +    +H AA  GH E
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649

Query: 188 VVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVAC 247
           +V LL+S  A     +K   TPLH  A  G + V   L+  GV ++     G TPLHVA 
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709

Query: 248 YNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGK 307
           + G   +V  L+   A VN K + G++PLH AA   H  + + LL+ NGA  N  S DG 
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI-VTLLLKNGASPNEVSSDGT 768

Query: 308 TPLHMTALHGRFS 320
           TPL +    G  S
Sbjct: 769 TPLAIAKRLGYIS 781



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 33/115 (28%), Positives = 53/115 (46%), Gaps = 4/115 (3%)

Query: 853 DSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEK 912
           ++   T  + AA +G  +     + +     T   N  N  LHLA  +GH     +++E 
Sbjct: 9   EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLN-GLHLASKEGH---VKMVVEL 64

Query: 913 ITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACA 967
           +    ++  T     T LH+AA  G   VV+EL+  GA+V A  + G+TP    A
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 119


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  327 bits (839), Expect = 3e-89
 Identities = 248/812 (30%), Positives = 388/812 (47%), Gaps = 33/812 (4%)

Query: 67  VNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126
           V  +++   T   RA  S + +     L++  D+N  ++N    LH+A+    VK    L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHI 186
           +     +  + + G TALH AA +G  E+V+ L++ GAN+NA  +K    ++ AA   H+
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 187 EVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVA 246
           EVVK L+ +GA      +  +TPL  A   G  +VV +L++ G             LH+A
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIA 180

Query: 247 CYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDG 306
             N        L+      +  ++ GFTPLH  AA        +LL+  GA VN   ++G
Sbjct: 181 ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI-AAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 307 KTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTA 366
            TPLH+ +  G     + ++  GA I+ + K+  TPLH AAR GH  +   L+  GA   
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299

Query: 367 KRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLN 426
            +  +G+ P+H+AA     DC R LL    +ID       T LH AA  G+     +LL+
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359

Query: 427 TGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGK 486
            GA  N +   G +PLH A    + + +  L+ +GAS++ + E G TPLH A+       
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMG-HLP 418

Query: 487 CLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSD 546
            ++ LL+  A+P + + +    +H +A  GH        +E    +L   +  +  +  D
Sbjct: 419 IVKNLLQRGASPNVSNVKVETPLHMAARAGH--------TEVAKYLLQNKAKVNAKAKDD 470

Query: 547 NRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQG 606
                +PLH AA  GH   +++L+++  + ++  ++G TPL +AA +GHVE V  L+ + 
Sbjct: 471 Q----TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526

Query: 607 ASILVKDYILKR--TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNG 664
           AS   +  + K+  TP+H AA  G      LL+      NA      NG TPL ++V + 
Sbjct: 527 AS---QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA---GKNGLTPLHVAVHHN 580

Query: 665 HTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIH 724
           + D V  LL +G +  +    G T LH  A     E   +LLQ+G        +G TP+H
Sbjct: 581 NLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLH 640

Query: 725 LSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVF-QK 783
           L+A  GH  ++  LL    S  AN    +  G T LH     GH    ++L++  V    
Sbjct: 641 LAAQEGHAEMVALLL----SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696

Query: 784 TEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLL 843
           T    ++PLH A    N    + L+     + VNA    G +PLH AA   H + + LLL
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQ--HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754

Query: 844 SHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875
            + A  N V S G TPL +A   G  +  ++L
Sbjct: 755 KNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  322 bits (826), Expect = 9e-88
 Identities = 250/784 (31%), Positives = 375/784 (47%), Gaps = 33/784 (4%)

Query: 180 AAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYG 239
           AA  G+++     + +G ++   ++     LH A+  G + +V  LL   + +      G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 240 NTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADV 299
           NT LH+A   GQD VV EL++ GA VN +++KGFTPL+ AA   H  + ++ L+ NGA+ 
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV-VKFLLENGANQ 137

Query: 300 NMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLI 359
           N+ ++DG TPL +    G  +    +I  G     + K     LHIAAR         L+
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTAAVLL 193

Query: 360 TSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLE 419
            +  +       G  PLH+AA     +  + LL+ G  ++     G T LH A+  GN+ 
Sbjct: 194 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVI 253

Query: 420 CLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAA 479
            + LLL+ GA    K K   +PLH AA N + +    L+  GA +    + G +P+H AA
Sbjct: 254 MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 313

Query: 480 TSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGT 539
             D    C+  LL+ DA            +H +A  GH    +++  +          G 
Sbjct: 314 QGD-HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK----------GA 362

Query: 540 DMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECV 599
              S + N  T  PLH+A    H + +E+L+++   +D    SG TPL +A+F GH+  V
Sbjct: 363 KPNSRALNGFT--PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420

Query: 600 DVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLML 659
             L+ +GAS  V + +   TP+H AA  GH+E  + L+ N    NA    D   QTPL  
Sbjct: 421 KNLLQRGASPNVSN-VKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD---QTPLHC 476

Query: 660 SVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRG 719
           +   GHT+ V  LL   AN +     G T LH  A  GH E V ALL+  A       +G
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 720 RTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQE 779
            TP+H++A  G + V   LL+     DA+P  A  +G T LH A ++ +   V+LLL + 
Sbjct: 537 FTPLHVAAKYGKVRVAELLLER----DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592

Query: 780 VFQKTEG-NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVEC 838
               +   N ++PLH A   +    A  L+   G++  NA   +G TPLH AA   H E 
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA--NAESVQGVTPLHLAAQEGHAEM 650

Query: 839 LQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLAC 898
           + LLLS  A  N  + +G TPL + A+ G     ++L+      +        T LH+A 
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG-VMVDATTRMGYTPLHVAS 709

Query: 899 SKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDEN 958
             G+      +L+   D   +NA      +PLH AA+ G T +V  LL  GAS   V  +
Sbjct: 710 HYGNIKLVKFLLQHQAD---VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766

Query: 959 GYTP 962
           G TP
Sbjct: 767 GTTP 770



 Score =  308 bits (790), Expect = 1e-83
 Identities = 233/767 (30%), Positives = 365/767 (47%), Gaps = 26/767 (3%)

Query: 11  SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
           S ++A  +G+ D+    +    D+N  +      LH A+  G  +++  L+     +   
Sbjct: 15  SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74

Query: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
             K  T LH A  +  +E V+ L+ + A+VNA+ +   TPL++AA    ++  + L+   
Sbjct: 75  TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134

Query: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 190
           +N NV+   G T L  A   GH  +V  L++ G       K    A+H AA         
Sbjct: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAA 190

Query: 191 LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 250
           +L+ +        K  +TPLH AA    ++V + LL+ G  +N     G TPLH+A   G
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250

Query: 251 QDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPL 310
             ++V  L+D GA +  K +   TPLH AA + H  +  E+L+ +GA +  K+K+G +P+
Sbjct: 251 NVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS-EILLDHGAPIQAKTKNGLSPI 309

Query: 311 HMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGI 370
           HM A        + ++Q  A ID    +  TPLH+AA  GH  +   L+  GA    R +
Sbjct: 310 HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369

Query: 371 HGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGAD 430
           +G  PLH+A           LL +G  ID   + G T LH A+  G+L  +  LL  GA 
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429

Query: 431 FNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEY 490
            N  +    +PLH AA   + +    L+ + A VN   +   TPLH AA        ++ 
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG-HTNMVKL 488

Query: 491 LLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRAT 550
           LL N+ANP +    G+  +H +A  GH         ET L +L + +    ++    +  
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGH--------VETVLALLEKEASQACMT----KKG 536

Query: 551 ISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASIL 610
            +PLH+AA +G  +  E+L++     +    +G TPL +A    +++ V +L+ +G S  
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596

Query: 611 VKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVY 670
              +    TP+H AA     E  R L+      NA  +Q   G TPL L+   GH + V 
Sbjct: 597 SPAW-NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ---GVTPLHLAAQEGHAEMVA 652

Query: 671 SLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACG 730
            LL+K AN +  +K G T LH  A  GH    D L++HG         G TP+H+++  G
Sbjct: 653 LLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYG 712

Query: 731 HIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLE 777
           +I ++  LLQ  A ++A        GY+ LH A   GH   V LLL+
Sbjct: 713 NIKLVKFLLQHQADVNAKTKL----GYSPLHQAAQQGHTDIVTLLLK 755



 Score =  296 bits (758), Expect = 7e-80
 Identities = 243/833 (29%), Positives = 372/833 (44%), Gaps = 40/833 (4%)

Query: 132 NVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKL 191
           +V   +    T+   AA SG+ +     L  G +IN  ++     +H A+  GH+++V  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 192 LVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQ 251
           L+     +    KK  T LH AA +G   VV+ L++ G ++N  +  G TPL++A     
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 252 DVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLH 311
             VV  L++ GA  N   E GFTPL  A    H     E +V +  +   K K     LH
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGH-----ENVVAHLINYGTKGKVRLPALH 178

Query: 312 MTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIH 371
           + A +     +  ++Q+    D   K G TPLHIAA Y +  +   L+  GA       +
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238

Query: 372 GMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADF 431
           G+ PLH+A+  G     R LL  G  I+T      T LH AA  G++    +LL+ GA  
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298

Query: 432 NKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYL 491
             K K G SP+H AA   +  C+  L+   A ++D+     TPLH AA      +  + L
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG-HHRVAKVL 357

Query: 492 LRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATI 551
           L   A P  R   G+  +H +    H   ++L+              T    D+   + +
Sbjct: 358 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK------------TGASIDAVTESGL 405

Query: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611
           +PLH+A++ GH   ++ L+Q     +V N    TPL +AA  GH E    L+   A +  
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465

Query: 612 KDYILKRTPIHAAATNGHSECLRLLI-GNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVY 670
           K     +TP+H AA  GH+  ++LL+  NA P  A       G TPL ++   GH + V 
Sbjct: 466 KAKD-DQTPLHCAARIGHTNMVKLLLENNANPNLATTA----GHTPLHIAAREGHVETVL 520

Query: 671 SLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACG 730
           +LL K A+     K G T LH  A  G     + LL+  A        G TP+H++    
Sbjct: 521 ALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHN 580

Query: 731 HIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEG-NAF 789
           ++ ++  LL    S    P +   +GYT LH A           LL+       E     
Sbjct: 581 NLDIVKLLLPRGGS----PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV 636

Query: 790 SPLHCAVINDNEGAAEMLIDTLGASI-VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQ 848
           +PLH A     EG AEM+   L      N  +  G TPLH  A   HV    +L+ H   
Sbjct: 637 TPLHLAA---QEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693

Query: 849 VNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALL 908
           V++    G TPL +A+  G    V+ L+    A++  +     + LH A  +GH     L
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQH-QADVNAKTKLGYSPLHQAAQQGHTDIVTL 752

Query: 909 ILEKITDRNLINATNAALQTPLHVAARNG---LTMVVQELLGKGASVLAVDEN 958
           +L+     N +++      TPL +A R G   +T V++ +  + + VL  D++
Sbjct: 753 LLKNGASPNEVSSDGT---TPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKH 802



 Score =  286 bits (731), Expect = 9e-77
 Identities = 214/720 (29%), Positives = 334/720 (46%), Gaps = 47/720 (6%)

Query: 15  AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 74
           A   G  + VR L+    +VN Q  +  TPL+ AA     E+++ L+ +GA  N      
Sbjct: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144

Query: 75  LTPL-----------------------------HRAVASCSEEAVQVLLKHSADVNARDK 105
            TPL                             H A  +       VLL++  + +   K
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204

Query: 106 NWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGAN 165
              TPLHIAA  + +  A+ L+   ++VN + + G T LH A+  G+  MV+LLL RGA 
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264

Query: 166 INAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYL 225
           I    K +   +H AA  GH+ + ++L+ HGA +  K K   +P+H AA    +  V+ L
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324

Query: 226 LDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHG 285
           L    ++++      TPLHVA + G   V   L+D GA  N +   GFTPLH A    H 
Sbjct: 325 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH- 383

Query: 286 ALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHI 345
              +ELL+  GA ++  ++ G TPLH+ +  G     + ++Q GA  +  +    TPLH+
Sbjct: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443

Query: 346 AARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFG 405
           AAR GH  +   L+ + A    +      PLH AA  G ++  + LL +  + +     G
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503

Query: 406 RTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVN 465
            T LH AA  G++E +  LL   A      K G +PLH AA     +    L+   A  N
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563

Query: 466 DLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIA 525
              + G TPLH  A    +   ++ LL    +P      GY  +H +A       +++  
Sbjct: 564 AAGKNGLTPLH-VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ---VEVAR 619

Query: 526 SETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRT 585
           S      L++  G+   +++++   ++PLHLAA  GH + + +L+    + ++ N SG T
Sbjct: 620 S------LLQYGGS---ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLT 670

Query: 586 PLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNA 645
           PL L A +GHV   DVLI  G  +      +  TP+H A+  G+ + ++ L+   + Q  
Sbjct: 671 PLHLVAQEGHVPVADVLIKHGVMVDATTR-MGYTPLHVASHYGNIKLVKFLL---QHQAD 726

Query: 646 VDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDAL 705
           V+ +   G +PL  +   GHTD V  LL  GA+ +     G T L      G+    D L
Sbjct: 727 VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  273 bits (699), Expect = 5e-73
 Identities = 192/600 (32%), Positives = 290/600 (48%), Gaps = 16/600 (2%)

Query: 10  PSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNA 69
           P+L  A  N D      L+    + +       TPLH AA+  +  + +LL+  GA VN 
Sbjct: 175 PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234

Query: 70  KDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPL 129
                +TPLH A    +   V++LL   A +  + K+  TPLH AA N  V+ +E L+  
Sbjct: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294

Query: 130 LSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVV 189
            + +    + G + +H AA   H + V+LLL   A I+         +H AA+ GH  V 
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354

Query: 190 KLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYN 249
           K+L+  GA+   +    +TPLH A     + V++ LL  G  ++     G TPLHVA + 
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414

Query: 250 GQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTP 309
           G   +V  L+  GA  N  N K  TPLH AA + H  +  + L+ N A VN K+KD +TP
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA-KYLLQNKAKVNAKAKDDQTP 473

Query: 310 LHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRG 369
           LH  A  G  +  + ++++ A  +     G+TPLHIAAR GH   +  L+   A  A   
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533

Query: 370 IHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGA 429
             G  PLH+AA  G       LL      +     G T LH A    NL+ + LLL  G 
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593

Query: 430 DFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLE 489
             +     G +PLH AA     +   +L+  G S N    +G TPLH AA  +   + + 
Sbjct: 594 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA-QEGHAEMVA 652

Query: 490 YLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPL-DVLMETSGTDMLSDSDNR 548
            LL   AN  + +K G   +H  A  GH           P+ DVL++     ++ D+  R
Sbjct: 653 LLLSKQANGNLGNKSGLTPLHLVAQEGH----------VPVADVLIKHG---VMVDATTR 699

Query: 549 ATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGAS 608
              +PLH+A+++G+ + ++ L+Q   D++ +   G +PL  AA +GH + V +L+  GAS
Sbjct: 700 MGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGAS 759



 Score =  259 bits (662), Expect = 9e-69
 Identities = 181/590 (30%), Positives = 280/590 (47%), Gaps = 17/590 (2%)

Query: 27  LIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCS 86
           L+ +   VNF      TPLH A+  G+  ++ LL+  GA++  K    LTPLH A  +  
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 284

Query: 87  EEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHH 146
               ++LL H A + A+ KN  +P+H+AA    + C   L+   + ++       T LH 
Sbjct: 285 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHV 344

Query: 147 AAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS 206
           AA  GH  + K+LL +GA  N+        +H A    H+ V++LL+  GA +    +  
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404

Query: 207 YTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVN 266
            TPLH A+  G + +VK LL  G   N  N    TPLH+A   G   V   L+   A VN
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464

Query: 267 QKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTII 326
            K +   TPLH AA   H  + ++LL+ N A+ N+ +  G TPLH+ A  G       ++
Sbjct: 465 AKAKDDQTPLHCAARIGHTNM-VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523

Query: 327 QSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSD 386
           +  A   C  K G TPLH+AA+YG   +   L+   A     G +G+ PLH+A      D
Sbjct: 524 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD 583

Query: 387 CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446
             + LL  G    +P   G T LH AA    +E    LL  G   N +   G +PLH AA
Sbjct: 584 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643

Query: 447 ANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGY 506
              + + +  L+   A+ N  ++ G TPLH  A  +      + L+++        + GY
Sbjct: 644 QEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA-QEGHVPVADVLIKHGVMVDATTRMGY 702

Query: 507 NAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQAL 566
             +H ++ YG+   ++ +  +   DV  +T           +   SPLH AA  GH   +
Sbjct: 703 TPLHVASHYGNIKLVKFLL-QHQADVNAKT-----------KLGYSPLHQAAQQGHTDIV 750

Query: 567 EVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL---INQGASILVKD 613
            +L+++    +  +S G TPL +A   G++   DVL    ++ + +LV D
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 800



 Score =  233 bits (595), Expect = 5e-61
 Identities = 192/636 (30%), Positives = 291/636 (45%), Gaps = 34/636 (5%)

Query: 346 AARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFG 405
           AAR G+       + +G D      +G+  LHLA+  G      +LL     ++T    G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 406 RTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVN 465
            T LH AA  G  E +  L+N GA+ N + + G +PL+ AA   + + +  L+ +GA+ N
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138

Query: 466 DLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGH-RLCLQLI 524
              E G TPL  A          E ++ +  N G + K    A+H +A     R    L+
Sbjct: 139 VATEDGFTPLAVALQQGH-----ENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLL 193

Query: 525 ASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGR 584
            ++   DVL +T  T             PLH+AA++ +    ++L+     ++    +G 
Sbjct: 194 QNDPNPDVLSKTGFT-------------PLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 240

Query: 585 TPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQN 644
           TPL +A+ +G+V  V +L+++GA I  K    + TP+H AA NGH     +L+ +  P  
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKD-ELTPLHCAARNGHVRISEILLDHGAP-- 297

Query: 645 AVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDA 704
            +  +  NG +P+ ++    H DCV  LL   A +D       T LH  A  GH      
Sbjct: 298 -IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 356

Query: 705 LLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWAC 764
           LL  GAK   R   G TP+H++    H+ V+  LL++ AS+DA        G T LH A 
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA----VTESGLTPLHVAS 412

Query: 765 YNGHETCVELLLEQEVFQKTEG-NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKG 823
           + GH   V+ LL++            +PLH A    +   A+ L+       VNA     
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK--VNAKAKDD 470

Query: 824 RTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAEL 883
           +TPLH AA   H   ++LLL +NA  N   + G TPL +AA  G   TV  L+   +++ 
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 884 TLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQ 943
            +      T LH+A   G    A L+LE+    N          TPLHVA  +    +V+
Sbjct: 531 CMTKKGF-TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL---TPLHVAVHHNNLDIVK 586

Query: 944 ELLGKGASVLAVDENGYTPALACAPNKDVADCLALI 979
            LL +G S  +   NGYTP    A    V    +L+
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622



 Score =  149 bits (377), Expect = 1e-35
 Identities = 107/313 (34%), Positives = 145/313 (46%), Gaps = 1/313 (0%)

Query: 8   DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
           DQ  L  A   G  + V+ L+    + N       TPLH AA  G  E +  L+   A  
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529

Query: 68  NAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALV 127
                K  TPLH A         ++LL+  A  NA  KN  TPLH+A  +  +   + L+
Sbjct: 530 ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589

Query: 128 PLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIE 187
           P   + +     G T LH AA     E+ + LL  G + NA   +    +H AA  GH E
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649

Query: 188 VVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVAC 247
           +V LL+S  A     +K   TPLH  A  G + V   L+  GV ++     G TPLHVA 
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709

Query: 248 YNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGK 307
           + G   +V  L+   A VN K + G++PLH AA   H  + + LL+ NGA  N  S DG 
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI-VTLLLKNGASPNEVSSDGT 768

Query: 308 TPLHMTALHGRFS 320
           TPL +    G  S
Sbjct: 769 TPLAIAKRLGYIS 781



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 33/115 (28%), Positives = 53/115 (46%), Gaps = 4/115 (3%)

Query: 853 DSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEK 912
           ++   T  + AA +G  +     + +     T   N  N  LHLA  +GH     +++E 
Sbjct: 9   EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLN-GLHLASKEGH---VKMVVEL 64

Query: 913 ITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACA 967
           +    ++  T     T LH+AA  G   VV+EL+  GA+V A  + G+TP    A
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 119


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  327 bits (839), Expect = 3e-89
 Identities = 248/812 (30%), Positives = 388/812 (47%), Gaps = 33/812 (4%)

Query: 67  VNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126
           V  +++   T   RA  S + +     L++  D+N  ++N    LH+A+    VK    L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHI 186
           +     +  + + G TALH AA +G  E+V+ L++ GAN+NA  +K    ++ AA   H+
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 187 EVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVA 246
           EVVK L+ +GA      +  +TPL  A   G  +VV +L++ G             LH+A
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIA 180

Query: 247 CYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDG 306
             N        L+      +  ++ GFTPLH  AA        +LL+  GA VN   ++G
Sbjct: 181 ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI-AAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 307 KTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTA 366
            TPLH+ +  G     + ++  GA I+ + K+  TPLH AAR GH  +   L+  GA   
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299

Query: 367 KRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLN 426
            +  +G+ P+H+AA     DC R LL    +ID       T LH AA  G+     +LL+
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359

Query: 427 TGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGK 486
            GA  N +   G +PLH A    + + +  L+ +GAS++ + E G TPLH A+       
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMG-HLP 418

Query: 487 CLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSD 546
            ++ LL+  A+P + + +    +H +A  GH        +E    +L   +  +  +  D
Sbjct: 419 IVKNLLQRGASPNVSNVKVETPLHMAARAGH--------TEVAKYLLQNKAKVNAKAKDD 470

Query: 547 NRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQG 606
                +PLH AA  GH   +++L+++  + ++  ++G TPL +AA +GHVE V  L+ + 
Sbjct: 471 Q----TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526

Query: 607 ASILVKDYILKR--TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNG 664
           AS   +  + K+  TP+H AA  G      LL+      NA      NG TPL ++V + 
Sbjct: 527 AS---QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA---GKNGLTPLHVAVHHN 580

Query: 665 HTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIH 724
           + D V  LL +G +  +    G T LH  A     E   +LLQ+G        +G TP+H
Sbjct: 581 NLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLH 640

Query: 725 LSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVF-QK 783
           L+A  GH  ++  LL    S  AN    +  G T LH     GH    ++L++  V    
Sbjct: 641 LAAQEGHAEMVALLL----SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696

Query: 784 TEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLL 843
           T    ++PLH A    N    + L+     + VNA    G +PLH AA   H + + LLL
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQ--HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754

Query: 844 SHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875
            + A  N V S G TPL +A   G  +  ++L
Sbjct: 755 KNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  322 bits (826), Expect = 9e-88
 Identities = 250/784 (31%), Positives = 375/784 (47%), Gaps = 33/784 (4%)

Query: 180 AAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYG 239
           AA  G+++     + +G ++   ++     LH A+  G + +V  LL   + +      G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 240 NTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADV 299
           NT LH+A   GQD VV EL++ GA VN +++KGFTPL+ AA   H  + ++ L+ NGA+ 
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV-VKFLLENGANQ 137

Query: 300 NMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLI 359
           N+ ++DG TPL +    G  +    +I  G     + K     LHIAAR         L+
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTAAVLL 193

Query: 360 TSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLE 419
            +  +       G  PLH+AA     +  + LL+ G  ++     G T LH A+  GN+ 
Sbjct: 194 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVI 253

Query: 420 CLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAA 479
            + LLL+ GA    K K   +PLH AA N + +    L+  GA +    + G +P+H AA
Sbjct: 254 MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 313

Query: 480 TSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGT 539
             D    C+  LL+ DA            +H +A  GH    +++  +          G 
Sbjct: 314 QGD-HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK----------GA 362

Query: 540 DMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECV 599
              S + N  T  PLH+A    H + +E+L+++   +D    SG TPL +A+F GH+  V
Sbjct: 363 KPNSRALNGFT--PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420

Query: 600 DVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLML 659
             L+ +GAS  V + +   TP+H AA  GH+E  + L+ N    NA    D   QTPL  
Sbjct: 421 KNLLQRGASPNVSN-VKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD---QTPLHC 476

Query: 660 SVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRG 719
           +   GHT+ V  LL   AN +     G T LH  A  GH E V ALL+  A       +G
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 720 RTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQE 779
            TP+H++A  G + V   LL+     DA+P  A  +G T LH A ++ +   V+LLL + 
Sbjct: 537 FTPLHVAAKYGKVRVAELLLER----DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592

Query: 780 VFQKTEG-NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVEC 838
               +   N ++PLH A   +    A  L+   G++  NA   +G TPLH AA   H E 
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA--NAESVQGVTPLHLAAQEGHAEM 650

Query: 839 LQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLAC 898
           + LLLS  A  N  + +G TPL + A+ G     ++L+      +        T LH+A 
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG-VMVDATTRMGYTPLHVAS 709

Query: 899 SKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDEN 958
             G+      +L+   D   +NA      +PLH AA+ G T +V  LL  GAS   V  +
Sbjct: 710 HYGNIKLVKFLLQHQAD---VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766

Query: 959 GYTP 962
           G TP
Sbjct: 767 GTTP 770



 Score =  308 bits (790), Expect = 1e-83
 Identities = 233/767 (30%), Positives = 365/767 (47%), Gaps = 26/767 (3%)

Query: 11  SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
           S ++A  +G+ D+    +    D+N  +      LH A+  G  +++  L+     +   
Sbjct: 15  SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74

Query: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
             K  T LH A  +  +E V+ L+ + A+VNA+ +   TPL++AA    ++  + L+   
Sbjct: 75  TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134

Query: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 190
           +N NV+   G T L  A   GH  +V  L++ G       K    A+H AA         
Sbjct: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAA 190

Query: 191 LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 250
           +L+ +        K  +TPLH AA    ++V + LL+ G  +N     G TPLH+A   G
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250

Query: 251 QDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPL 310
             ++V  L+D GA +  K +   TPLH AA + H  +  E+L+ +GA +  K+K+G +P+
Sbjct: 251 NVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS-EILLDHGAPIQAKTKNGLSPI 309

Query: 311 HMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGI 370
           HM A        + ++Q  A ID    +  TPLH+AA  GH  +   L+  GA    R +
Sbjct: 310 HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369

Query: 371 HGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGAD 430
           +G  PLH+A           LL +G  ID   + G T LH A+  G+L  +  LL  GA 
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429

Query: 431 FNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEY 490
            N  +    +PLH AA   + +    L+ + A VN   +   TPLH AA        ++ 
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG-HTNMVKL 488

Query: 491 LLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRAT 550
           LL N+ANP +    G+  +H +A  GH         ET L +L + +    ++    +  
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGH--------VETVLALLEKEASQACMT----KKG 536

Query: 551 ISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASIL 610
            +PLH+AA +G  +  E+L++     +    +G TPL +A    +++ V +L+ +G S  
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596

Query: 611 VKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVY 670
              +    TP+H AA     E  R L+      NA  +Q   G TPL L+   GH + V 
Sbjct: 597 SPAW-NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ---GVTPLHLAAQEGHAEMVA 652

Query: 671 SLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACG 730
            LL+K AN +  +K G T LH  A  GH    D L++HG         G TP+H+++  G
Sbjct: 653 LLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYG 712

Query: 731 HIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLE 777
           +I ++  LLQ  A ++A        GY+ LH A   GH   V LLL+
Sbjct: 713 NIKLVKFLLQHQADVNAKTKL----GYSPLHQAAQQGHTDIVTLLLK 755



 Score =  296 bits (758), Expect = 7e-80
 Identities = 243/833 (29%), Positives = 372/833 (44%), Gaps = 40/833 (4%)

Query: 132 NVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKL 191
           +V   +    T+   AA SG+ +     L  G +IN  ++     +H A+  GH+++V  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 192 LVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQ 251
           L+     +    KK  T LH AA +G   VV+ L++ G ++N  +  G TPL++A     
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 252 DVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLH 311
             VV  L++ GA  N   E GFTPL  A    H     E +V +  +   K K     LH
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGH-----ENVVAHLINYGTKGKVRLPALH 178

Query: 312 MTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIH 371
           + A +     +  ++Q+    D   K G TPLHIAA Y +  +   L+  GA       +
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238

Query: 372 GMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADF 431
           G+ PLH+A+  G     R LL  G  I+T      T LH AA  G++    +LL+ GA  
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298

Query: 432 NKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYL 491
             K K G SP+H AA   +  C+  L+   A ++D+     TPLH AA      +  + L
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG-HHRVAKVL 357

Query: 492 LRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATI 551
           L   A P  R   G+  +H +    H   ++L+              T    D+   + +
Sbjct: 358 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK------------TGASIDAVTESGL 405

Query: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611
           +PLH+A++ GH   ++ L+Q     +V N    TPL +AA  GH E    L+   A +  
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465

Query: 612 KDYILKRTPIHAAATNGHSECLRLLI-GNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVY 670
           K     +TP+H AA  GH+  ++LL+  NA P  A       G TPL ++   GH + V 
Sbjct: 466 KAKD-DQTPLHCAARIGHTNMVKLLLENNANPNLATTA----GHTPLHIAAREGHVETVL 520

Query: 671 SLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACG 730
           +LL K A+     K G T LH  A  G     + LL+  A        G TP+H++    
Sbjct: 521 ALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHN 580

Query: 731 HIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEG-NAF 789
           ++ ++  LL    S    P +   +GYT LH A           LL+       E     
Sbjct: 581 NLDIVKLLLPRGGS----PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV 636

Query: 790 SPLHCAVINDNEGAAEMLIDTLGASI-VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQ 848
           +PLH A     EG AEM+   L      N  +  G TPLH  A   HV    +L+ H   
Sbjct: 637 TPLHLAA---QEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693

Query: 849 VNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALL 908
           V++    G TPL +A+  G    V+ L+    A++  +     + LH A  +GH     L
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQH-QADVNAKTKLGYSPLHQAAQQGHTDIVTL 752

Query: 909 ILEKITDRNLINATNAALQTPLHVAARNG---LTMVVQELLGKGASVLAVDEN 958
           +L+     N +++      TPL +A R G   +T V++ +  + + VL  D++
Sbjct: 753 LLKNGASPNEVSSDGT---TPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKH 802



 Score =  286 bits (731), Expect = 9e-77
 Identities = 214/720 (29%), Positives = 334/720 (46%), Gaps = 47/720 (6%)

Query: 15  AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 74
           A   G  + VR L+    +VN Q  +  TPL+ AA     E+++ L+ +GA  N      
Sbjct: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144

Query: 75  LTPL-----------------------------HRAVASCSEEAVQVLLKHSADVNARDK 105
            TPL                             H A  +       VLL++  + +   K
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204

Query: 106 NWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGAN 165
              TPLHIAA  + +  A+ L+   ++VN + + G T LH A+  G+  MV+LLL RGA 
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264

Query: 166 INAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYL 225
           I    K +   +H AA  GH+ + ++L+ HGA +  K K   +P+H AA    +  V+ L
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324

Query: 226 LDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHG 285
           L    ++++      TPLHVA + G   V   L+D GA  N +   GFTPLH A    H 
Sbjct: 325 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH- 383

Query: 286 ALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHI 345
              +ELL+  GA ++  ++ G TPLH+ +  G     + ++Q GA  +  +    TPLH+
Sbjct: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443

Query: 346 AARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFG 405
           AAR GH  +   L+ + A    +      PLH AA  G ++  + LL +  + +     G
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503

Query: 406 RTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVN 465
            T LH AA  G++E +  LL   A      K G +PLH AA     +    L+   A  N
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563

Query: 466 DLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIA 525
              + G TPLH  A    +   ++ LL    +P      GY  +H +A       +++  
Sbjct: 564 AAGKNGLTPLH-VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ---VEVAR 619

Query: 526 SETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRT 585
           S      L++  G+   +++++   ++PLHLAA  GH + + +L+    + ++ N SG T
Sbjct: 620 S------LLQYGGS---ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLT 670

Query: 586 PLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNA 645
           PL L A +GHV   DVLI  G  +      +  TP+H A+  G+ + ++ L+   + Q  
Sbjct: 671 PLHLVAQEGHVPVADVLIKHGVMVDATTR-MGYTPLHVASHYGNIKLVKFLL---QHQAD 726

Query: 646 VDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDAL 705
           V+ +   G +PL  +   GHTD V  LL  GA+ +     G T L      G+    D L
Sbjct: 727 VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  273 bits (699), Expect = 5e-73
 Identities = 192/600 (32%), Positives = 290/600 (48%), Gaps = 16/600 (2%)

Query: 10  PSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNA 69
           P+L  A  N D      L+    + +       TPLH AA+  +  + +LL+  GA VN 
Sbjct: 175 PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234

Query: 70  KDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPL 129
                +TPLH A    +   V++LL   A +  + K+  TPLH AA N  V+ +E L+  
Sbjct: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294

Query: 130 LSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVV 189
            + +    + G + +H AA   H + V+LLL   A I+         +H AA+ GH  V 
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354

Query: 190 KLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYN 249
           K+L+  GA+   +    +TPLH A     + V++ LL  G  ++     G TPLHVA + 
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414

Query: 250 GQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTP 309
           G   +V  L+  GA  N  N K  TPLH AA + H  +  + L+ N A VN K+KD +TP
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA-KYLLQNKAKVNAKAKDDQTP 473

Query: 310 LHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRG 369
           LH  A  G  +  + ++++ A  +     G+TPLHIAAR GH   +  L+   A  A   
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533

Query: 370 IHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGA 429
             G  PLH+AA  G       LL      +     G T LH A    NL+ + LLL  G 
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593

Query: 430 DFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLE 489
             +     G +PLH AA     +   +L+  G S N    +G TPLH AA  +   + + 
Sbjct: 594 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA-QEGHAEMVA 652

Query: 490 YLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPL-DVLMETSGTDMLSDSDNR 548
            LL   AN  + +K G   +H  A  GH           P+ DVL++     ++ D+  R
Sbjct: 653 LLLSKQANGNLGNKSGLTPLHLVAQEGH----------VPVADVLIKHG---VMVDATTR 699

Query: 549 ATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGAS 608
              +PLH+A+++G+ + ++ L+Q   D++ +   G +PL  AA +GH + V +L+  GAS
Sbjct: 700 MGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGAS 759



 Score =  259 bits (662), Expect = 9e-69
 Identities = 181/590 (30%), Positives = 280/590 (47%), Gaps = 17/590 (2%)

Query: 27  LIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCS 86
           L+ +   VNF      TPLH A+  G+  ++ LL+  GA++  K    LTPLH A  +  
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 284

Query: 87  EEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHH 146
               ++LL H A + A+ KN  +P+H+AA    + C   L+   + ++       T LH 
Sbjct: 285 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHV 344

Query: 147 AAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS 206
           AA  GH  + K+LL +GA  N+        +H A    H+ V++LL+  GA +    +  
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404

Query: 207 YTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVN 266
            TPLH A+  G + +VK LL  G   N  N    TPLH+A   G   V   L+   A VN
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464

Query: 267 QKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTII 326
            K +   TPLH AA   H  + ++LL+ N A+ N+ +  G TPLH+ A  G       ++
Sbjct: 465 AKAKDDQTPLHCAARIGHTNM-VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523

Query: 327 QSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSD 386
           +  A   C  K G TPLH+AA+YG   +   L+   A     G +G+ PLH+A      D
Sbjct: 524 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD 583

Query: 387 CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446
             + LL  G    +P   G T LH AA    +E    LL  G   N +   G +PLH AA
Sbjct: 584 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643

Query: 447 ANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGY 506
              + + +  L+   A+ N  ++ G TPLH  A  +      + L+++        + GY
Sbjct: 644 QEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA-QEGHVPVADVLIKHGVMVDATTRMGY 702

Query: 507 NAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQAL 566
             +H ++ YG+   ++ +  +   DV  +T           +   SPLH AA  GH   +
Sbjct: 703 TPLHVASHYGNIKLVKFLL-QHQADVNAKT-----------KLGYSPLHQAAQQGHTDIV 750

Query: 567 EVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL---INQGASILVKD 613
            +L+++    +  +S G TPL +A   G++   DVL    ++ + +LV D
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 800



 Score =  233 bits (595), Expect = 5e-61
 Identities = 192/636 (30%), Positives = 291/636 (45%), Gaps = 34/636 (5%)

Query: 346 AARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFG 405
           AAR G+       + +G D      +G+  LHLA+  G      +LL     ++T    G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 406 RTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVN 465
            T LH AA  G  E +  L+N GA+ N + + G +PL+ AA   + + +  L+ +GA+ N
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138

Query: 466 DLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGH-RLCLQLI 524
              E G TPL  A          E ++ +  N G + K    A+H +A     R    L+
Sbjct: 139 VATEDGFTPLAVALQQGH-----ENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLL 193

Query: 525 ASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGR 584
            ++   DVL +T  T             PLH+AA++ +    ++L+     ++    +G 
Sbjct: 194 QNDPNPDVLSKTGFT-------------PLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 240

Query: 585 TPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQN 644
           TPL +A+ +G+V  V +L+++GA I  K    + TP+H AA NGH     +L+ +  P  
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKD-ELTPLHCAARNGHVRISEILLDHGAP-- 297

Query: 645 AVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDA 704
            +  +  NG +P+ ++    H DCV  LL   A +D       T LH  A  GH      
Sbjct: 298 -IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 356

Query: 705 LLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWAC 764
           LL  GAK   R   G TP+H++    H+ V+  LL++ AS+DA        G T LH A 
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA----VTESGLTPLHVAS 412

Query: 765 YNGHETCVELLLEQEVFQKTEG-NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKG 823
           + GH   V+ LL++            +PLH A    +   A+ L+       VNA     
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK--VNAKAKDD 470

Query: 824 RTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAEL 883
           +TPLH AA   H   ++LLL +NA  N   + G TPL +AA  G   TV  L+   +++ 
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 884 TLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQ 943
            +      T LH+A   G    A L+LE+    N          TPLHVA  +    +V+
Sbjct: 531 CMTKKGF-TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL---TPLHVAVHHNNLDIVK 586

Query: 944 ELLGKGASVLAVDENGYTPALACAPNKDVADCLALI 979
            LL +G S  +   NGYTP    A    V    +L+
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622



 Score =  149 bits (377), Expect = 1e-35
 Identities = 107/313 (34%), Positives = 145/313 (46%), Gaps = 1/313 (0%)

Query: 8   DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
           DQ  L  A   G  + V+ L+    + N       TPLH AA  G  E +  L+   A  
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529

Query: 68  NAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALV 127
                K  TPLH A         ++LL+  A  NA  KN  TPLH+A  +  +   + L+
Sbjct: 530 ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589

Query: 128 PLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIE 187
           P   + +     G T LH AA     E+ + LL  G + NA   +    +H AA  GH E
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649

Query: 188 VVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVAC 247
           +V LL+S  A     +K   TPLH  A  G + V   L+  GV ++     G TPLHVA 
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709

Query: 248 YNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGK 307
           + G   +V  L+   A VN K + G++PLH AA   H  + + LL+ NGA  N  S DG 
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI-VTLLLKNGASPNEVSSDGT 768

Query: 308 TPLHMTALHGRFS 320
           TPL +    G  S
Sbjct: 769 TPLAIAKRLGYIS 781



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 33/115 (28%), Positives = 53/115 (46%), Gaps = 4/115 (3%)

Query: 853 DSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEK 912
           ++   T  + AA +G  +     + +     T   N  N  LHLA  +GH     +++E 
Sbjct: 9   EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLN-GLHLASKEGH---VKMVVEL 64

Query: 913 ITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACA 967
           +    ++  T     T LH+AA  G   VV+EL+  GA+V A  + G+TP    A
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 119


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  285 bits (728), Expect = 2e-76
 Identities = 213/649 (32%), Positives = 314/649 (48%), Gaps = 31/649 (4%)

Query: 4    LKLRDQPSLVQAIFNGDP--DEVRALIFKKEDV---------NFQDNEKRTPLHAAAYLG 52
            L+L      +  I+NG P  D +  LI K+++V         +    + RT       L 
Sbjct: 464  LQLETAELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALE 523

Query: 53   DAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLH 112
              + I  L+ +GA VN  DS   T L  A  S S + V +L+   AD+   D +  TPL 
Sbjct: 524  REDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLT 583

Query: 113  IAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKK 172
            +AA     K    L+   +N+N +D+ G TAL  AA+ GH E+V  LL  G  ++  D  
Sbjct: 584  LAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADAD 643

Query: 173  DRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDM 232
             R A+  AA+ GH ++V  L+ HGAEV   D +  T L AAA  G   +V++LLD G ++
Sbjct: 644  SRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEV 703

Query: 233  NEPNAYGNTPLHVACY-----NGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGAL 287
            N  +  G T L VA        G   VV+ LID GA V+  ++ G TPL  AA   H  +
Sbjct: 704  NHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDV 763

Query: 288  CLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAA 347
             ++LL+  GADV+    +G+TPL   A  G  S   T++  GA +D  D  G T L IA+
Sbjct: 764  -VDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIAS 822

Query: 348  RYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRT 407
              G+  ++ TL+  G D   R   G  PLH+AA  G    C  L+  G   +  D+ GR 
Sbjct: 823  AQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRI 882

Query: 408  CLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDL 467
                A+  G+ +C+ +LL   ++ +++   GR+ L  AA   +   +  L   GA VN  
Sbjct: 883  PFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCK 942

Query: 468  DERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASE 527
            D  G  P  Y    +      EY L N AN    D +G  A+H S   GH   +Q     
Sbjct: 943  DADG-RPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQ----- 996

Query: 528  TPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPL 587
                VL+        +D++ R   S L  AA+ GH + +++L++    +D   + G T L
Sbjct: 997  ----VLIAYHADVNAADNEKR---SALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATAL 1049

Query: 588  DLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLL 636
             +AA +GH++ V VL+  GA     D    RT +  AA NGHS+ ++LL
Sbjct: 1050 CIAAQEGHIDVVQVLLEHGADPNHADQ-FGRTAMRVAAKNGHSQIIKLL 1097



 Score =  258 bits (659), Expect = 2e-68
 Identities = 228/777 (29%), Positives = 351/777 (45%), Gaps = 79/777 (10%)

Query: 254  VVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMT 313
            V+  L+  GA VN ++++    +  A         +  L+ NGA VN    +G+T L   
Sbjct: 496  VLQLLVKAGAHVNSEDDRTSCIVRQALEREDS---IRTLLDNGASVNQCDSNGRTLLANA 552

Query: 314  ALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGM 373
            A  G       ++  GA ++ ED +G+TPL +AAR GH  ++N LI  GA+       G 
Sbjct: 553  AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGW 612

Query: 374  FPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNK 433
              L  AA  G ++    LL +G  +D  D   RT L AAA GG+ + +  LL  GA+ NK
Sbjct: 613  TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNK 672

Query: 434  KDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAA----TSDTDGKCLE 489
             D  GR+ L  AA   + + +  L+  GA VN  D  G T L  AA     S      + 
Sbjct: 673  ADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVS 732

Query: 490  YLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRA 549
             L+   A     DK G   +  +A  GH            +D+L+E  G D+    +N  
Sbjct: 733  LLIDRGAEVDHCDKDGMTPLLVAAYEGH---------VDVVDLLLE-GGADVDHTDNNGR 782

Query: 550  TISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI 609
            T  PL  AA  GH   +  L+     +D  +S GRT L +A+ +G+VE V  L+++G   
Sbjct: 783  T--PLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDE 840

Query: 610  LVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCV 669
              +D     TP+H AA  GH      LI      N +D    +G+ P +L+   GH DCV
Sbjct: 841  NHRDDA-GWTPLHMAAFEGHRLICEALIEQGARTNEID---NDGRIPFILASQEGHYDCV 896

Query: 670  YSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAAC 729
              LL   +N+D +   GR AL   A+ GH + V+ L  HGA    +D+ GR  +++ A  
Sbjct: 897  QILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALE 956

Query: 730  GHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAF 789
              + +    L++ A+++A    +D  G TALH +C+ GH   V++L+             
Sbjct: 957  NQLTMAEYFLENGANVEA----SDAEGRTALHVSCWQGHMEMVQVLIAYH---------- 1002

Query: 790  SPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQV 849
                                    + VNA D++ R+ L +AA+  HV+ +QLL+ H A V
Sbjct: 1003 ------------------------ADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVV 1038

Query: 850  NSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLI 909
            +   + G T L +AA+ G  + V++L+    A+    D    TA+ +A   GH +  + +
Sbjct: 1039 DHTCNQGATALCIAAQEGHIDVVQVLLEH-GADPNHADQFGRTAMRVAAKNGH-SQIIKL 1096

Query: 910  LEKITDRNLINATNAALQTPLHVAAR---NGLTMVVQELLGKGASVLAVDENGYTPALAC 966
            LEK    +L    N    +P+H   +     L+  VQ L  K  S  +       P+L  
Sbjct: 1097 LEKYGASSL----NGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGSTGGGDMQPSLRG 1152

Query: 967  APNKDVADCLALILATMMPVSS-SSPLSSLTFNAINRYTN-----TSKTVSFEALPI 1017
             PN       A    +  P S+     SSL+ N++    N     TS T + + +PI
Sbjct: 1153 LPN---GPTHAFSSPSESPDSTVDRQKSSLSNNSLKSSKNSSLRTTSSTATAQTVPI 1206



 Score =  220 bits (561), Expect = 5e-57
 Identities = 163/501 (32%), Positives = 242/501 (48%), Gaps = 41/501 (8%)

Query: 11   SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
            +L  A + G  + V AL++    V+  D + RT L AAA+ G  +I+  L+  GA VN  
Sbjct: 614  ALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKA 673

Query: 71   DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAA-ANKAVKCAEALVPL 129
            D++  T L  A      E V+ LL H A+VN  D + +T L +AA    A K   ++V L
Sbjct: 674  DNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSL 733

Query: 130  L----SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGH 185
            L    + V+  D+ G T L  AA+ GH ++V LLL  GA+++  D   R  +  AA MGH
Sbjct: 734  LIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGH 793

Query: 186  IEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245
              VV  L+  GA V   D +  T L  A++ G + VV+ LLD G+D N  +  G TPLH+
Sbjct: 794  ASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHM 853

Query: 246  ACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTH--------------------- 284
            A + G  ++   LI+ GA  N+ +  G  P   A+   H                     
Sbjct: 854  AAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDG 913

Query: 285  ------GAL-----CLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVID 333
                   AL      +ELL  +GADVN K  DG+  L++ AL  + + ++  +++GA ++
Sbjct: 914  RNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVE 973

Query: 334  CEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLS 393
              D  G T LH++   GH  ++  LI   AD           L  AA  G     + L+ 
Sbjct: 974  ASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIE 1033

Query: 394  SGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQC 453
             G  +D   + G T L  AA  G+++ + +LL  GAD N  D+FGR+ +  AA N + Q 
Sbjct: 1034 HGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQI 1093

Query: 454  LFALVGSGASVNDLDERGCTP 474
            +  L   GAS       GC+P
Sbjct: 1094 IKLLEKYGAS----SLNGCSP 1110



 Score =  164 bits (414), Expect = 5e-40
 Identities = 137/464 (29%), Positives = 218/464 (46%), Gaps = 58/464 (12%)

Query: 523 LIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSS 582
           LI  E  +  L+  +G  + S+ D  + I    L        ++  L+ +   ++  +S+
Sbjct: 489 LIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALE----REDSIRTLLDNGASVNQCDSN 544

Query: 583 GRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEP 642
           GRT L  AA+ G ++ V++L+++GA +                                 
Sbjct: 545 GRTLLANAAYSGSLDVVNLLVSRGADL--------------------------------- 571

Query: 643 QNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECV 702
               +I+D +G TPL L+   GHT  V  L+  GAN++  D+ G TAL   A  GH E V
Sbjct: 572 ----EIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVV 627

Query: 703 DALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHW 762
            ALL  G K    D+  RT +  +A  GH  ++  LLQ  A ++     ADN G TAL  
Sbjct: 628 SALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN----KADNEGRTALIA 683

Query: 763 ACYNGHETCVELLLEQEV---FQKTEGNAFSPLHCAVINDNEGAA---EMLIDTLGASIV 816
           A Y GH   VE LL+       +  +G     +    +  ++G A    +LID  GA  V
Sbjct: 684 AAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDR-GAE-V 741

Query: 817 NATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLV 876
           +  D  G TPL  AA+  HV+ + LLL   A V+  D+ G+TPL+ AA  G  + V  L+
Sbjct: 742 DHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLL 801

Query: 877 SSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARN 936
              +A  ++ D+   T L +A ++G+      +L++  D    N  + A  TPLH+AA  
Sbjct: 802 FWGAAVDSI-DSEGRTVLSIASAQGNVEVVRTLLDRGLDE---NHRDDAGWTPLHMAAFE 857

Query: 937 GLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALIL 980
           G  ++ + L+ +GA    +D +G  P +  A  +   DC+ ++L
Sbjct: 858 GHRLICEALIEQGARTNEIDNDGRIPFI-LASQEGHYDCVQILL 900


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
          Length = 2352

 Score =  272 bits (695), Expect = 1e-72
 Identities = 270/931 (29%), Positives = 412/931 (44%), Gaps = 51/931 (5%)

Query: 52   GDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARD-KNWQTP 110
            GD   +  L++ G  VN    +  + L  A ++   E  QVLL   A+V  R  K   TP
Sbjct: 245  GDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITP 304

Query: 111  LHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFD 170
            L  AA    VK  + L+   ++VN     G TAL +A   G+ ++VK+LL  GA+I   +
Sbjct: 305  LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHN 364

Query: 171  KKDRRAIHWAAYMGHIEVVKLLVSHGAEV-TCKDKKSYTPLHAAASSGMISVVKYLLDLG 229
            +     +  A   GH+EV +LL+ +GA + T  ++   + L  A   G + +V++LL+ G
Sbjct: 365  ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAG 424

Query: 230  VDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCL 289
             D        +T L  AC +G   V   L+D GA VN   +   +PL  AA   H  L  
Sbjct: 425  ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 484

Query: 290  ELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCE-DKNGNTPLHIAAR 348
             LL+  GA +   + +G TPL   A  G       ++  GA I+ + ++   T L +A  
Sbjct: 485  -LLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACC 543

Query: 349  YGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTC 408
             G   + + LI +GAD     +    PL  AA  G  +  + LL++G ++      G T 
Sbjct: 544  GGFLEVADFLIKAGADIE---LGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600

Query: 409  LHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLD 468
            L  A   G+ +  ++LL  GAD   + + GR+PL  AA   +   +  L+  GA+VN   
Sbjct: 601  LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 660

Query: 469  ERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHR--LCLQL--- 523
                  +   A +      +E LL + A+P  R K G   +  +A  GH   +C  L   
Sbjct: 661  ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP 720

Query: 524  --IASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLL-DLDVRN 580
              + S  P DV   T  +  L    NRA   P+         QAL ++V     D    N
Sbjct: 721  NNLLSAPPPDVTQLTPPSHDL----NRAPRVPV---------QALPMVVPPQEPDKPPAN 767

Query: 581  SSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNA 640
             +   P+   A  G    +    N     +       +TP  +   +  S  L +     
Sbjct: 768  VATTLPIRNKAVSGRASAMS---NTPTHSIAASISQPQTPTPSPIISP-SAMLPIY---- 819

Query: 641  EPQNAVDIQ-DGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHE 699
             P   +D Q + N  T L L+   GH + V +LL +GA+++ +DK G T L   A  GH 
Sbjct: 820  -PAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHV 878

Query: 700  ECVDALLQHGAKCLLRDSRGR-TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYT 758
              V+ LL +GA    +  R + TP+ L+ + G   V+  LL   A+ +    +     YT
Sbjct: 879  GVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVS----DYT 934

Query: 759  ALHWACYNGHETCVELLLEQ--EVFQKTEGN-AFSPLHCAVINDNEGAAEMLIDTLGASI 815
             L  A   G+   +++LL    E+  +T      SPL  A +N +  A ++L+D +G+ I
Sbjct: 935  PLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLD-MGSDI 993

Query: 816  VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875
                ++   T L  A F    E + LLL   A V     TG TPLM AA  G      +L
Sbjct: 994  NAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1053

Query: 876  VSS-ASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAA 934
            +   A        +S++TAL +A  KGH     L++ +      I+  N    TPL +AA
Sbjct: 1054 LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAH---IDVRNKKGNTPLWLAA 1110

Query: 935  RNGLTMVVQELLGKGASVLAVDENGYTPALA 965
              G   VVQ L+  GA V A D    TP +A
Sbjct: 1111 NGGHLDVVQLLVQAGADVDAADNRKITPLMA 1141



 Score =  264 bits (674), Expect = 4e-70
 Identities = 259/942 (27%), Positives = 406/942 (43%), Gaps = 110/942 (11%)

Query: 8    DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
            D  SL +A   GD + VR L+ +   VN    E  + L  A   G  E+ ++L+   A V
Sbjct: 234  DNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 293

Query: 68   NAKDSKW-LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126
              +  K  +TPL  A      + V++LL H ADVNA+     T L  A A   V   + L
Sbjct: 294  EDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVL 353

Query: 127  VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR-AIHWAAYMGH 185
            +   +++   +  G T L  A  +GH E+ +LLL  GA IN    + +  A+  A Y GH
Sbjct: 354  LESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGH 413

Query: 186  IEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245
            +E+V+ L+  GA+   K  + +T L  A   G + V + LLD G  +N P     +PL +
Sbjct: 414  LEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 473

Query: 246  ACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 305
            A   G   +   LI+ GA + + N++G+TPL  AA   H  + + LL+G GA++N ++++
Sbjct: 474  AACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEM-VALLLGQGANINAQTEE 532

Query: 306  GK-------------------------------TPLHMTALHGRFSRSQTIIQSGAVIDC 334
             +                               TPL   A  G     + ++ +GA +  
Sbjct: 533  TQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHA 592

Query: 335  EDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSS 394
                G+T L  A   GH  + + L+ +GAD       G  PL  AA +G     + L+S 
Sbjct: 593  TTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652

Query: 395  GFDID-TPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQC 453
            G +++ T  +   T L  A AGG+L  + LLL  GAD   + K G + L  AA   +   
Sbjct: 653  GANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSV 712

Query: 454  LFALVGSGASV---------------NDLDERGCTPLH----YAATSDTD----GKCLEY 490
            +  L+    ++               +DL+     P+          + D          
Sbjct: 713  VCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTL 772

Query: 491  LLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRAT 550
             +RN A  G          H  AA      +    + TP  ++  ++   +    D  A 
Sbjct: 773  PIRNKAVSGRASAMSNTPTHSIAA-----SISQPQTPTPSPIISPSAMLPIYPAIDIDAQ 827

Query: 551  ISPLH-----LAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQ 605
                H     LA   GH + ++ L++    ++ R+  G TPL LAA  GHV  V++L++ 
Sbjct: 828  TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 887

Query: 606  GASILVKDYILKRTPIHAAATNGHSECLRLLIG---NAEPQNAVDI-------------- 648
            GA I  +    K TP+  A + G  E + LL+    N E +N  D               
Sbjct: 888  GADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNI 947

Query: 649  -------------QDGN--GQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGR-TALHR 692
                         + G+  G +PLML+ +NGHT  V  LL+ G++++A+ +  R TAL  
Sbjct: 948  IKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTL 1007

Query: 693  GAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATA 752
                G  E V  LL   A    R   G TP+  +A+ G+  V   LL   A ++A P  +
Sbjct: 1008 ACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPS 1067

Query: 753  DNHGYTALHWACYNGHETCVELLLEQEVF---QKTEGNAFSPLHCAVINDNEGAAEMLID 809
                 TAL  A   GH    ELL+ +      +  +GN  +PL  A    +    ++L+ 
Sbjct: 1068 SRD--TALTIAADKGHYKFCELLIGRGAHIDVRNKKGN--TPLWLAANGGHLDVVQLLVQ 1123

Query: 810  TLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNS 851
              GA  V+A D++  TPL AA    HV+ ++ L+    Q  S
Sbjct: 1124 A-GAD-VDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPS 1163



 Score =  224 bits (572), Expect = 3e-58
 Identities = 257/934 (27%), Positives = 399/934 (42%), Gaps = 60/934 (6%)

Query: 55   EIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIA 114
            E    L+LSG    A D + + P  +A      EA  +    +AD     K +  P  + 
Sbjct: 148  ETASKLLLSGTADGA-DLRTVDPETQARLEALLEAAGIGKLSTAD----GKAFADPEVLR 202

Query: 115  AANKAVKCA--EALVPLL-----SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANIN 167
                +V CA  EA   L      S  N      R+ L  A   G    V+ LL  G ++N
Sbjct: 203  RLTSSVSCALDEAAAALTRMRAESTANAGQSDNRS-LAEACSEGDVNAVRKLLIEGRSVN 261

Query: 168  AFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKD-KKSYTPLHAAASSGMISVVKYLL 226
               ++    +  A   G+ E+ ++L++  A V  +  K   TPL AAA+ G + +VK LL
Sbjct: 262  EHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLL 321

Query: 227  DLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGA 286
                D+N  ++ GNT L  AC  G   VV  L++ GA +   NE G TPL  A ++ H  
Sbjct: 322  AHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVE 381

Query: 287  LCLELLVGNGADVNMKSKDGK-TPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHI 345
            +   LL+ NGA +N  S + K + L +    G     + ++++GA  + +    +T L  
Sbjct: 382  VA-RLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALME 440

Query: 346  AARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFG 405
            A   GH  +   L+ SGA           PL LAA  G  +    L+  G  ++  +D G
Sbjct: 441  ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEG 500

Query: 406  RTCLHAAAAGGNLECLNLLLNTGADFN-KKDKFGRSPLHYAAANCNYQCLFALVGSGASV 464
             T L  AA  G+ E + LLL  GA+ N + ++   + L  A      +    L+ +GA +
Sbjct: 501  YTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADI 560

Query: 465  NDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLI 524
                E GC+     A  +   + ++YLL   AN       G  A+ Y+   GH       
Sbjct: 561  ----ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGH------- 609

Query: 525  ASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLD-VRNSSG 583
                  DVL++ +G D+  +S+   T  PL  AA  GH   ++ L+    +++    ++ 
Sbjct: 610  --TDVADVLLQ-AGADLEHESEGGRT--PLMKAARAGHVCTVQFLISKGANVNRTTANND 664

Query: 584  RTPLDLAAFKGHVECVDVLINQGA--SILVKDYILKRTPIHAAATNGHSECLRLLIGNAE 641
             T L LA   GH+  V++L+  GA  +  +KD     T +  AA  GH+  +  L+    
Sbjct: 665  HTVLSLACAGGHLAVVELLLAHGADPTHRLKD---GSTMLIEAAKGGHTSVVCYLLDYPN 721

Query: 642  PQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTA-----LHRGAVT 696
               +    D    TP     LN         L         DK          +   AV+
Sbjct: 722  NLLSAPPPDVTQLTPPSHD-LNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVS 780

Query: 697  GHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHG 756
            G    +     H     +   +  TP  + +         A+L    ++D +  T  NH 
Sbjct: 781  GRASAMSNTPTHSIAASISQPQTPTPSPIISP-------SAMLPIYPAIDIDAQTESNHD 833

Query: 757  YTALHWACYNGHETCVELLLEQEV-FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASI 815
             TAL  AC  GHE  V+ LLE+    +  +   F+PL  A    + G  E+L+D  GA I
Sbjct: 834  -TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN-GADI 891

Query: 816  VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875
               ++    TPL  A      E ++LLL+  A     + +  TPL +AA  G  N +++L
Sbjct: 892  EAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL 951

Query: 876  VSSASAELTLQDNSK--NTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVA 933
            + +A AE+  +  SK   + L LA   GH  +  L+L+  +D N    TN    T L +A
Sbjct: 952  L-NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNR--NTALTLA 1008

Query: 934  ARNGLTMVVQELLGKGASVLAVDENGYTPALACA 967
               G T VV  LL + A+V    + G TP +  A
Sbjct: 1009 CFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAA 1042



 Score =  175 bits (443), Expect = 2e-43
 Identities = 198/771 (25%), Positives = 317/771 (41%), Gaps = 61/771 (7%)

Query: 240 NTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADV 299
           N  L  AC  G    V +L+  G  VN+  E+G + L  A ++ +  L   LL  +    
Sbjct: 235 NRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVE 294

Query: 300 NMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLI 359
           +   K   TPL   A  G     + ++   A ++ +   GNT L  A   G+  ++  L+
Sbjct: 295 DRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLL 354

Query: 360 TSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDT-PDDFGRTCLHAAAAGGNL 418
            SGA       +G  PL  A  +G  +  R LL +G  I+T  ++F  + L  A   G+L
Sbjct: 355 ESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHL 414

Query: 419 ECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYA 478
           E +  LL  GAD   K     + L  A  + + +    L+ SGA VN   +   +PL  A
Sbjct: 415 EMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLA 474

Query: 479 ATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSG 538
           A           + R  +   + D +GY  +  +A  GH   + L+  +          G
Sbjct: 475 ACGGHVELAALLIERGASLEEVND-EGYTPLMEAAREGHEEMVALLLGQ----------G 523

Query: 539 TDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVEC 598
            ++ + ++     + L LA   G  +  + L+++  D+++  S   TPL  AA +GH+E 
Sbjct: 524 ANINAQTEETQETA-LTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLEL 579

Query: 599 VDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGN--GQTP 656
           V  L+  GA++         T +  A  NGH++   +L+     Q   D++  +  G+TP
Sbjct: 580 VKYLLAAGANVHATT-ATGDTALTYACENGHTDVADVLL-----QAGADLEHESEGGRTP 633

Query: 657 LMLSVLNGHTDCVYSLLNKGANVDAKDKWG-RTALHRGAVTGHEECVDALLQHGAKCLLR 715
           LM +   GH   V  L++KGANV+        T L      GH   V+ LL HGA    R
Sbjct: 634 LMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHR 693

Query: 716 DSRGRTPIHLSAACGHIGVLGALLQ------SAASMDANPATADNHGYTALHWACYNGHE 769
              G T +  +A  GH  V+  LL       SA   D    T  +H              
Sbjct: 694 LKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALP 753

Query: 770 TCVEL---------------LLEQEVFQKTEGNAFSPLHCAVINDNE----------GAA 804
             V                 +  + V  +    + +P H    + ++            +
Sbjct: 754 MVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPS 813

Query: 805 EMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAA 864
            ML       I   T+S   T L  A    H E +Q LL   A +   D  G TPL++AA
Sbjct: 814 AMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAA 873

Query: 865 ENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNA 924
             G    VE+L+ + +      + +K+T L LACS G +    L+L +  ++   N ++ 
Sbjct: 874 TAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSD- 932

Query: 925 ALQTPLHVAARNGLTMVVQELLGKGASV--LAVDENGYTPALACAPNKDVA 973
              TPL +AA  G   +++ LL  GA +      + G +P +  A N   A
Sbjct: 933 --YTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTA 981



 Score =  148 bits (373), Expect = 3e-35
 Identities = 169/651 (25%), Positives = 274/651 (42%), Gaps = 98/651 (15%)

Query: 2    AFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLI 61
            A ++L     L++A   G  + V+ L+    +V+       T L  A   G  ++ ++L+
Sbjct: 558  ADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLL 617

Query: 62   LSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVN-ARDKNWQTPLHIAAANKAV 120
             +GA +  +     TPL +A  +     VQ L+   A+VN     N  T L +A A   +
Sbjct: 618  QAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHL 677

Query: 121  KCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKD------- 173
               E L+   ++     + G T L  AA  GH  +V  LL    N+ +    D       
Sbjct: 678  AVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPP 737

Query: 174  ----RRA-----------------------------IHWAAYMGHIEVVKLLVSHGAEVT 200
                 RA                             I   A  G    +    +H    +
Sbjct: 738  SHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAAS 797

Query: 201  CKDKKSYTPLHAAASSGMISVVKYL-LDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELI 259
                ++ TP    + S M+ +   + +D   + N      +T L +AC  G + +V  L+
Sbjct: 798  ISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNH-----DTALTLACAGGHEELVQTLL 852

Query: 260  DCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGK-TPLHMTALHGR 318
            + GA +  +++KGFTPL  AA + H  + +E+L+ NGAD+  +S+  K TPL +    GR
Sbjct: 853  ERGASIEHRDKKGFTPLILAATAGHVGV-VEILLDNGADIEAQSERTKDTPLSLACSGGR 911

Query: 319  FSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKR--GIHGMFPL 376
                + ++  GA  +  + +  TPL +AA  G+  +I  L+ +GA+   R     G+ PL
Sbjct: 912  QEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPL 971

Query: 377  HLAALSGFSDCCRKLLSSGFDIDTPDDFGR-TCLHAAAAGGNLECLNLLLNTGADFNKKD 435
             LAA++G +   + LL  G DI+   +  R T L  A   G  E ++LLL+  A+   + 
Sbjct: 972  MLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA 1031

Query: 436  KFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRND 495
            K G +PL  AA+    +    L+  GA VN        P+                    
Sbjct: 1032 KTGLTPLMEAASGGYAEVGRVLLDKGADVN------APPV-------------------- 1065

Query: 496  ANPGIRDKQGYNAVHYSAAYGH-RLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPL 554
              P  RD     A+  +A  GH + C  LI     +DV              N+   +PL
Sbjct: 1066 --PSSRD----TALTIAADKGHYKFCELLIGRGAHIDV-------------RNKKGNTPL 1106

Query: 555  HLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQ 605
             LAA  GH   +++LVQ+  D+D  ++   TPL  A  KGHV+ V  L+ +
Sbjct: 1107 WLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 32/122 (26%), Positives = 60/122 (49%), Gaps = 3/122 (2%)

Query: 27   LIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCS 86
            LI +   ++ ++ +  TPL  AA  G  ++++LL+ +GA V+A D++ +TPL  A     
Sbjct: 1088 LIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGH 1147

Query: 87   EEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHH 146
             + V+ L+K   +VN    + +   +IA         +  + + S V   DR    A  +
Sbjct: 1148 VKVVRYLVK---EVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKN 1204

Query: 147  AA 148
            A+
Sbjct: 1205 AS 1206


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
            polymerase [Homo sapiens]
          Length = 1327

 Score =  246 bits (628), Expect = 8e-65
 Identities = 253/886 (28%), Positives = 382/886 (43%), Gaps = 140/886 (15%)

Query: 131  SNVNVSDRAGRTA--LHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEV 188
            +NVN  D AGR +  LH AA  G  ++V+ LL  GAN++A D      +H A   GH EV
Sbjct: 205  ANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEV 264

Query: 189  VKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACY 248
            V LL+  GA+   +D  +YTPLH AA  G I V   LL  G D N  N  G + L +A  
Sbjct: 265  VSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADP 324

Query: 249  NGQDVVV-----NELIDCGAIVNQK----------------NEKGFTPLHFAAASTHGAL 287
            + + V+      +EL++     N++                + +  TPLH AA      +
Sbjct: 325  SAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRI 384

Query: 288  CLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAA 347
             ++LL+ +GADV+ K K G  PLH    +G +  ++ +++ GA ++  D    TPLH AA
Sbjct: 385  -VQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAA 443

Query: 348  RYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCC------RKLLSSGFDID-- 399
                  + + L++ GAD      HG   + +A      +          LL +  + D  
Sbjct: 444  SKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLA 503

Query: 400  -------------TPDDFGRTCLHAAAAG---GNLECLNLLLNTGADFNKKDKFGRSPLH 443
                                T LH A A       +   LLL  GA+ N+K+K   +PLH
Sbjct: 504  KVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLH 563

Query: 444  YAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDK 503
             AA   +   +  L   GA +N LD  G T LH AA +     C   LL   ++P I   
Sbjct: 564  VAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTC-RLLLSYGSDPSIISL 622

Query: 504  QGYNAVHYSAAYGHRLCLQLIASETPL---DV---LMETSGTDMLS-------------- 543
            QG+ A    A  G+    Q+++  TP+   DV   L+E S    L               
Sbjct: 623  QGFTA----AQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCR 678

Query: 544  DSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLI 603
            D + R + +PLH AA +     +E L+    D+  ++  G  PL  A   GH E  ++L+
Sbjct: 679  DLEGRHS-TPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLV 737

Query: 604  NQGASILVKDYILKRTPIHAAATNGHSECLRLLIGN-AEPQNAVDIQDGNGQTPLMLSVL 662
              GAS+ V D + K TP+H AA  G  E  +LL+ + A+P      ++ +G TPL L V 
Sbjct: 738  RHGASVNVAD-LWKFTPLHEAAAKGKYEICKLLLKHGADPTK----KNRDGNTPLDL-VK 791

Query: 663  NGHTDCVYSLLNKGA---------------------NVDAKDKWGR--TALHRGAVTGHE 699
             G TD +  LL   A                     N++ +D  GR  T LH  A   + 
Sbjct: 792  EGDTD-IQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNL 850

Query: 700  ECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTA 759
            E  + LL+HGA    +D  G  P+H +A+ GH+ +   L++    ++A     D   +T 
Sbjct: 851  EVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNA----TDKWAFTP 906

Query: 760  LHWACYNGHETCVELLL---EQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTL----- 811
            LH A   G      LLL        +  EG   +PL  A  +D      +LID +     
Sbjct: 907  LHEAAQKGRTQLCALLLAHGADPTMKNQEGQ--TPLDLATADD---IRALLIDAMPPEAL 961

Query: 812  ------GASIVNAT-DSKGRTP--LHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMM 862
                   A++V+A+  S   TP  L AA+  D++      L+     N+ D    T    
Sbjct: 962  PTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGT---- 1017

Query: 863  AAENGQTNTVEMLVSSASAELTLQD-----NSKNTALHLACSKGHE 903
              + G+   ++M +S     L L+       ++   L +    GHE
Sbjct: 1018 ERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHE 1063



 Score =  234 bits (597), Expect = 3e-61
 Identities = 230/768 (29%), Positives = 332/768 (43%), Gaps = 129/768 (16%)

Query: 12  LVQAIFNGDPDEVRALIFKKEDVNFQD--NEKRTPLHAAAYLGDAEIIELLILSGARVNA 69
           L++A  NGD   V+ L+    +VN +D    K +PLH AA  G  +++E L+  GA V+A
Sbjct: 186 LLEACRNGDVSRVKRLV-DAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHA 244

Query: 70  KDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQ-TPLHIAA------------- 115
           +D   L PLH A +    E V +LL   AD NARD NW  TPLH AA             
Sbjct: 245 RDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARD-NWNYTPLHEAAIKGKIDVCIVLLQ 303

Query: 116 ---------------------ANKAV--------------------KCAEALVPLLSNVN 134
                                + KAV                    K    L PL  N +
Sbjct: 304 HGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCH 363

Query: 135 VSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVS 194
            SD    T LH AA      +V+LLL  GA+++A DK     +H A   GH EV +LL+ 
Sbjct: 364 ASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLK 423

Query: 195 HGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVAC------- 247
           HGA V   D   +TPLH AAS   + V   LL  G D    N +G + + +A        
Sbjct: 424 HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRER 483

Query: 248 ----YNGQDVV----------VNELIDCGAIVNQKNEKGFTPLHFAAASTH--GALCLEL 291
               + G  ++          V + +    I  ++ +   T LH A AS H       EL
Sbjct: 484 LTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTEL 543

Query: 292 LVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGH 351
           L+  GA+VN K+KD  TPLH+ A        + + + GA ++  D  G T LH AA  GH
Sbjct: 544 LLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGH 603

Query: 352 ELLINTLITSGADTAKRGIHGM--------------------------FPLHLAALSGFS 385
                 L++ G+D +   + G                           + L  A+ +G  
Sbjct: 604 LQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDL 663

Query: 386 DCCRKLLSSGFDIDTPDDFGR--TCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLH 443
           +  ++L SS  +++  D  GR  T LH AA    +  +  LL+ GAD + KDK G  PLH
Sbjct: 664 ETVKQLCSSQ-NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLH 722

Query: 444 YAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDK 503
            A +  +Y+    LV  GASVN  D    TPLH AA       C + LL++ A+P  +++
Sbjct: 723 NACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEIC-KLLLKHGADPTKKNR 781

Query: 504 QGYNAVHYSAAYGHRLCLQLIASETPLDVLME----------TSGTDMLSDSDNRATISP 553
            G   +         +   L      LD   +          T       D+  R + +P
Sbjct: 782 DGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNS-TP 840

Query: 554 LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 613
           LHLAA + + +  E L++   D++ ++  G  PL  AA  GHV+   +LI     +   D
Sbjct: 841 LHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATD 900

Query: 614 YILKRTPIHAAATNGHSE-CLRLLIGNAEPQNAVDIQDGNGQTPLMLS 660
                TP+H AA  G ++ C  LL   A+P     +++  GQTPL L+
Sbjct: 901 K-WAFTPLHEAAQKGRTQLCALLLAHGADP----TMKNQEGQTPLDLA 943



 Score =  213 bits (543), Expect = 6e-55
 Identities = 236/817 (28%), Positives = 353/817 (43%), Gaps = 91/817 (11%)

Query: 213 AASSGMISVVKYLLDLG-VDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEK 271
           A  +G +S VK L+D   V+  +     ++PLH A   G+  VV  L+  GA V+ +++ 
Sbjct: 189 ACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDG 248

Query: 272 GFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAV 331
           G  PLH A +  H  + + LL+  GAD N +     TPLH  A+ G+      ++Q GA 
Sbjct: 249 GLIPLHNACSFGHAEV-VSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAD 307

Query: 332 IDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKL 391
            +  + +G + L +A                A     G +    L  AA SG  +    L
Sbjct: 308 PNIRNTDGKSALDLA-------------DPSAKAVLTGEYKKDELLEAARSGNEEKLMAL 354

Query: 392 LSS-GFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCN 450
           L+    +    D    T LH AA    +  + LLL  GAD + KDK G  PLH A +  +
Sbjct: 355 LTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGH 414

Query: 451 YQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVH 510
           Y+    L+  GA VN +D    TPLH AA+ +    C   LL + A+P + +  G +AV 
Sbjct: 415 YEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVC-SLLLSHGADPTLVNCHGKSAVD 473

Query: 511 YSAA-----------YGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAY 559
            +              GH L LQ  A E  L  + +T   ++++    ++  + LH A  
Sbjct: 474 MAPTPELRERLTYEFKGHSL-LQA-AREADLAKVKKTLALEIINFKQPQSHETALHCAVA 531

Query: 560 HGH---HQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYIL 616
             H    Q  E+L++   +++ +N    TPL +AA + H + ++VL   GA +   D  L
Sbjct: 532 SLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALD-TL 590

Query: 617 KRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQD------GNGQTPLMLSVLNG--HTDC 668
            +T +H AA  GH +  RLL+      + + +Q       GN     +LS       +D 
Sbjct: 591 GQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDV 650

Query: 669 VYSLLN--------------KGANVDAKDKWGR--TALHRGAVTGHEECVDALLQHGAKC 712
            Y LL                  NV+ +D  GR  T LH  A       V+ LL HGA  
Sbjct: 651 DYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADV 710

Query: 713 LLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNG-HETC 771
             +D  G  P+H + + GH  V   L++  AS++     AD   +T LH A   G +E C
Sbjct: 711 HAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNV----ADLWKFTPLHEAAAKGKYEIC 766

Query: 772 VELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAA 831
             LL       K   +  +PL      D +     + D L          +G   L  AA
Sbjct: 767 KLLLKHGADPTKKNRDGNTPLDLVKEGDTD-----IQDLL----------RGDAALLDAA 811

Query: 832 FTDHVECLQLLLSHNAQVNSVDSTGK--TPLMMAAENGQTNTVEMLVSSASAELTLQDNS 889
               +  +Q L +    +N  D+ G+  TPL +AA        E L+    A++  QD  
Sbjct: 812 KKGCLARVQKLCTPE-NINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHG-ADVNAQDKG 869

Query: 890 KNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKG 949
               LH A S GH   A L+++  T    +NAT+    TPLH AA+ G T +   LL  G
Sbjct: 870 GLIPLHNAASYGHVDIAALLIKYNT---CVNATDKWAFTPLHEAAQKGRTQLCALLLAHG 926

Query: 950 ASVLAVDENGYTPA-LACAPNKDVADCLALILATMMP 985
           A     ++ G TP  LA A      D  AL++  M P
Sbjct: 927 ADPTMKNQEGQTPLDLATAD-----DIRALLIDAMPP 958



 Score =  189 bits (479), Expect = 2e-47
 Identities = 158/466 (33%), Positives = 222/466 (47%), Gaps = 39/466 (8%)

Query: 11  SLVQAIFNGDPDEVRALIFKKEDVNF-QDNEKRTPLHAAA---YLGDAEIIELLILSGAR 66
           SL+QA    D  +V+  +   E +NF Q     T LH A    +    ++ ELL+  GA 
Sbjct: 492 SLLQAAREADLAKVKKTL-ALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGAN 550

Query: 67  VNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126
           VN K+  ++TPLH A      + ++VL KH A +NA D   QT LH AA    ++    L
Sbjct: 551 VNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLL 610

Query: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHI 186
           +   S+ ++    G TA          E V+ +LS    I   D  D R +  A+  G +
Sbjct: 611 LSYGSDPSIISLQGFTAAQMG-----NEAVQQILSESTPIRTSD-VDYRLLE-ASKAGDL 663

Query: 187 EVVKLLVSHGAEVTCKD--KKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLH 244
           E VK L S    V C+D   +  TPLH AA    +SVV+YLL  G D++  +  G  PLH
Sbjct: 664 ETVKQLCS-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLH 722

Query: 245 VACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSK 304
            AC  G   V   L+  GA VN  +   FTPLH AAA     +C +LL+ +GAD   K++
Sbjct: 723 NACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEIC-KLLLKHGADPTKKNR 781

Query: 305 DGKTPLHM--------------------TALHGRFSRSQTIIQSGAVIDCEDKNG--NTP 342
           DG TPL +                     A  G  +R Q +  +   I+C D  G  +TP
Sbjct: 782 DGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLC-TPENINCRDTQGRNSTP 840

Query: 343 LHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPD 402
           LH+AA Y +  +   L+  GAD   +   G+ PLH AA  G  D    L+     ++  D
Sbjct: 841 LHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATD 900

Query: 403 DFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAAN 448
            +  T LH AA  G  +   LLL  GAD   K++ G++PL  A A+
Sbjct: 901 KWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATAD 946



 Score =  129 bits (323), Expect = 2e-29
 Identities = 100/305 (32%), Positives = 147/305 (48%), Gaps = 26/305 (8%)

Query: 12  LVQAIFNGDPDEVRALIFKKEDVNFQDNEKR--TPLHAAAYLGDAEIIELLILSGARVNA 69
           L++A   GD + V+ L    ++VN +D E R  TPLH AA      ++E L+  GA V+A
Sbjct: 654 LLEASKAGDLETVKQLC-SSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA 712

Query: 70  KDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPL 129
           KD   L PLH A +    E  ++L++H A VN  D    TPLH AAA    +  + L+  
Sbjct: 713 KDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKH 772

Query: 130 LSNVNVSDRAGRT--------------------ALHHAAFSGHGEMVKLLLSRGANINAF 169
            ++    +R G T                    AL  AA  G    V+ L +   NIN  
Sbjct: 773 GADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTP-ENINCR 831

Query: 170 DKKDRRA--IHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLD 227
           D + R +  +H AA   ++EV + L+ HGA+V  +DK    PLH AAS G + +   L+ 
Sbjct: 832 DTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIK 891

Query: 228 LGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGAL 287
               +N  + +  TPLH A   G+  +   L+  GA    KN++G TPL  A A    AL
Sbjct: 892 YNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRAL 951

Query: 288 CLELL 292
            ++ +
Sbjct: 952 LIDAM 956



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 34/120 (28%), Positives = 52/120 (43%), Gaps = 3/120 (2%)

Query: 860 LMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLI 919
           L+ A  NG  + V+ LV +A+         K++ LH A   G +     +L+   +   +
Sbjct: 186 LLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGAN---V 242

Query: 920 NATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALI 979
           +A +     PLH A   G   VV  LL +GA   A D   YTP    A    +  C+ L+
Sbjct: 243 HARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLL 302


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score =  243 bits (621), Expect = 5e-64
 Identities = 234/767 (30%), Positives = 336/767 (43%), Gaps = 129/767 (16%)

Query: 12  LVQAIFNGDPDEVRALIFKKEDVNFQDN--EKRTPLHAAAYLGDAEIIELLILSGARVNA 69
           L +A  NGD + V+ L+   E VN +D    K TPLH AA  G  +++E L+ +GA V A
Sbjct: 28  LFEACRNGDVERVKRLV-TPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQA 86

Query: 70  KDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQ-TPLHIAA------------- 115
           +D   L PLH A +    E V +LL+H AD NARD NW  TPLH AA             
Sbjct: 87  RDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARD-NWNYTPLHEAAIKGKIDVCIVLLQ 145

Query: 116 ---------------------ANKAV--------------------KCAEALVPLLSNVN 134
                                + KAV                    K    L PL  N +
Sbjct: 146 HGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCH 205

Query: 135 VSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVS 194
            SD    T LH AA     ++V+LLL  GA+++A DK D   +H A   GH EV +LLV 
Sbjct: 206 ASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK 265

Query: 195 HGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVAC------- 247
           HGA V   D   +TPLH AAS   + V   LL  G D    N +  + + +A        
Sbjct: 266 HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKER 325

Query: 248 ----YNGQDVV----------VNELIDCGAIVNQKNEKGFTPLHFAAASTH---GALCLE 290
               + G  ++          + + +    +  +  +   T LH AAAS +     +C E
Sbjct: 326 LAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQIC-E 384

Query: 291 LLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYG 350
           LL+  GA++N K+K+  TPLH+ +        + +++  A ++  D  G T LH AA  G
Sbjct: 385 LLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCG 444

Query: 351 HELLINTLITSGADTAKRGIHGMFPLHLAALS-----------GFSDCCRKLL--SSGFD 397
           H      L++ G D     + G   L +   +           G S+  R+LL  +   D
Sbjct: 445 HLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGD 504

Query: 398 IDT------------PDDFGR--TCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLH 443
           ++T             D  GR  T LH AA    +  +  LL  GAD + KDK G  PLH
Sbjct: 505 VETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLH 564

Query: 444 YAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDK 503
            A +  +Y+    LV  GA VN  D    TPLH AA       C + LL++ A+P  +++
Sbjct: 565 NACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEIC-KLLLQHGADPTKKNR 623

Query: 504 QGYNAVH---------YSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATIS-P 553
            G   +               G    L   A +  L  + + S  D ++  D +   S P
Sbjct: 624 DGNTPLDLVKDGDTDIQDLLRGDAALLD-AAKKGCLARVKKLSSPDNVNCRDTQGRHSTP 682

Query: 554 LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 613
           LHLAA + + +  E L+Q   D++ ++  G  PL  AA  GHV+   +LI   A +   D
Sbjct: 683 LHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATD 742

Query: 614 YILKRTPIHAAATNGHSE-CLRLLIGNAEPQNAVDIQDGNGQTPLML 659
                TP+H AA  G ++ C  LL   A+P     +++  GQTPL L
Sbjct: 743 K-WAFTPLHEAAQKGRTQLCALLLAHGADP----TLKNQEGQTPLDL 784



 Score =  236 bits (601), Expect = 1e-61
 Identities = 218/730 (29%), Positives = 318/730 (43%), Gaps = 99/730 (13%)

Query: 133 VNVSDRAGR--TALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 190
           VN  D AGR  T LH AA  G  ++V+ LL  GAN+ A D      +H A   GH EVV 
Sbjct: 49  VNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVN 108

Query: 191 LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 250
           LL+ HGA+   +D  +YTPLH AA  G I V   LL  G +    N  G T L +A  + 
Sbjct: 109 LLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSA 168

Query: 251 QDVVV-----NELIDCGAIVNQK----------------NEKGFTPLHFAAASTHGALCL 289
           + V+      +EL++     N++                + +  TPLH AA      + +
Sbjct: 169 KAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKI-V 227

Query: 290 ELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARY 349
           +LL+ +GADV+ K K    PLH    +G +  ++ +++ GA ++  D    TPLH AA  
Sbjct: 228 QLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASK 287

Query: 350 GHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCC------RKLLSSGFDIDTP-- 401
               + + L++ GAD      H    + LA      +          LL +  + D    
Sbjct: 288 NRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRI 347

Query: 402 -------------DDFGRTCLHAAAAG---GNLECLNLLLNTGADFNKKDKFGRSPLHYA 445
                             T LH AAA       +   LLL  GA+ N+K K   +PLH A
Sbjct: 348 KKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVA 407

Query: 446 AANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQG 505
           +   +   +  +V   A VN LD  G T LH AA       C   LL    +P I   QG
Sbjct: 408 SEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTC-RLLLSYGCDPNIISLQG 466

Query: 506 YNAVHYSAAYGHRLCLQLIA---SETPLDVLMETSGTDM-------------LSDSDNRA 549
           + A+        +L  + I+   SE    +L      D+               D + R 
Sbjct: 467 FTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQ 526

Query: 550 TISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI 609
           + +PLH AA +     +E L+Q   D+  ++  G  PL  A   GH E  ++L+  GA +
Sbjct: 527 S-TPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVV 585

Query: 610 LVKDYILKRTPIHAAATNGHSECLRLLIGN-AEPQNAVDIQDGNGQTPLMLSVLNGHTD- 667
            V D + K TP+H AA  G  E  +LL+ + A+P      ++ +G TPL L V +G TD 
Sbjct: 586 NVAD-LWKFTPLHEAAAKGKYEICKLLLQHGADPTK----KNRDGNTPLDL-VKDGDTDI 639

Query: 668 -----------------CVYSL--LNKGANVDAKDKWGR--TALHRGAVTGHEECVDALL 706
                            C+  +  L+   NV+ +D  GR  T LH  A   + E  + LL
Sbjct: 640 QDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLL 699

Query: 707 QHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYN 766
           QHGA    +D  G  P+H +A+ GH+ V   L++  A ++A     D   +T LH A   
Sbjct: 700 QHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNA----TDKWAFTPLHEAAQK 755

Query: 767 GHETCVELLL 776
           G      LLL
Sbjct: 756 GRTQLCALLL 765



 Score =  198 bits (504), Expect = 2e-50
 Identities = 242/851 (28%), Positives = 352/851 (41%), Gaps = 92/851 (10%)

Query: 243  LHVACYNGQDVVVNELIDCGAIVNQKNEKG--FTPLHFAAASTHGALCLELLVGNGADVN 300
            L  AC NG    V  L+     VN ++  G   TPLHFAA      + +E L+ NGA+V 
Sbjct: 28   LFEACRNGDVERVKRLVTPEK-VNSRDTAGRKSTPLHFAAGFGRKDV-VEYLLQNGANVQ 85

Query: 301  MKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLIT 360
             +   G  PLH     G       +++ GA  +  D    TPLH AA  G   +   L+ 
Sbjct: 86   ARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 145

Query: 361  SGADTAKRGIHGMFPLHLA--------------------ALSGFSDCCRKLLSS-GFDID 399
             GA+   R   G   L LA                    A SG  +    LL+    +  
Sbjct: 146  HGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCH 205

Query: 400  TPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVG 459
              D    T LH AA    ++ + LLL  GAD + KDK    PLH A +  +Y+    LV 
Sbjct: 206  ASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK 265

Query: 460  SGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSA------ 513
             GA VN +D    TPLH AA+ +    C   LL   A+P + +    +A+  +       
Sbjct: 266  HGACVNAMDLWQFTPLHEAASKNRVEVC-SLLLSYGADPTLLNCHNKSAIDLAPTPQLKE 324

Query: 514  --AY---GHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAA---YHGHHQA 565
              AY   GH L LQ  A E  +  + +    +M++    +   + LH AA   Y    Q 
Sbjct: 325  RLAYEFKGHSL-LQA-AREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQI 382

Query: 566  LEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAA 625
             E+L++   +++ +     TPL +A+ K H + V+V++   A +   D  L +T +H AA
Sbjct: 383  CELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDN-LGQTSLHRAA 441

Query: 626  TNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKW 685
              GH +  RLL+      N + +Q   G T L +   N     V  LL +G ++   +  
Sbjct: 442  YCGHLQTCRLLLSYGCDPNIISLQ---GFTALQMGNEN-----VQQLLQEGISLGNSE-- 491

Query: 686  GRTALHRGAVTGHEECVDALLQ-HGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAAS 744
                L   A  G  E V  L       C   + R  TP+H +A    + V+  LLQ  A 
Sbjct: 492  ADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGAD 551

Query: 745  MDANPATADNHGYTALHWACYNGHETCVELLLEQ-EVFQKTEGNAFSPLHCAVINDNEGA 803
            + A     D  G   LH AC  GH    ELL++   V    +   F+PLH A        
Sbjct: 552  VHAK----DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEI 607

Query: 804  AEMLIDTLGASIVNATDSKGRTPLHA---------------AAFTDHVE--CLQLL--LS 844
             ++L+   GA      +  G TPL                 AA  D  +  CL  +  LS
Sbjct: 608  CKLLLQH-GADPTKK-NRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLS 665

Query: 845  HNAQVNSVDSTGK--TPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGH 902
                VN  D+ G+  TPL +AA        E L+    A++  QD      LH A S GH
Sbjct: 666  SPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHG-ADVNAQDKGGLIPLHNAASYGH 724

Query: 903  ETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 962
               A L+++       +NAT+    TPLH AA+ G T +   LL  GA     ++ G TP
Sbjct: 725  VDVAALLIKY---NACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTP 781

Query: 963  ALACAPNKDVADCLALILATMMPVSSSSPLSSLTFNAINRYTNTSKTVSFEALPIMRNEP 1022
                + +    D  AL+ A M P +  S       N +     T+  +S  + P   +  
Sbjct: 782  LDLVSAD----DVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALS--SGPSSPSSL 835

Query: 1023 SSYCSFNNIGG 1033
            S+  S +N+ G
Sbjct: 836  SAASSLDNLSG 846



 Score =  196 bits (498), Expect = 1e-49
 Identities = 159/466 (34%), Positives = 227/466 (48%), Gaps = 39/466 (8%)

Query: 11  SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKR-TPLHAAA---YLGDAEIIELLILSGAR 66
           SL+QA    D   ++  +   E VNF+  +   T LH AA   Y    +I ELL+  GA 
Sbjct: 334 SLLQAAREADVTRIKKHL-SLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGAN 392

Query: 67  VNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126
           +N K  ++LTPLH A      + V+V++KH A VNA D   QT LH AA    ++    L
Sbjct: 393 INEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLL 452

Query: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHI 186
           +    + N+    G TAL         E V+ LL  G ++    + DR+ +  AA  G +
Sbjct: 453 LSYGCDPNIISLQGFTALQMG-----NENVQQLLQEGISLGN-SEADRQLLE-AAKAGDV 505

Query: 187 EVVKLLVSHGAEVTCKD--KKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLH 244
           E VK L +    V C+D   +  TPLH AA    +SVV+YLL  G D++  +  G  PLH
Sbjct: 506 ETVKKLCT-VQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLH 564

Query: 245 VACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSK 304
            AC  G   V   L+  GA+VN  +   FTPLH AAA     +C +LL+ +GAD   K++
Sbjct: 565 NACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEIC-KLLLQHGADPTKKNR 623

Query: 305 DGKTPLHM--------------------TALHGRFSRSQTIIQSGAVIDCEDKNG--NTP 342
           DG TPL +                     A  G  +R +  + S   ++C D  G  +TP
Sbjct: 624 DGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKK-LSSPDNVNCRDTQGRHSTP 682

Query: 343 LHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPD 402
           LH+AA Y +  +   L+  GAD   +   G+ PLH AA  G  D    L+     ++  D
Sbjct: 683 LHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATD 742

Query: 403 DFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAAN 448
            +  T LH AA  G  +   LLL  GAD   K++ G++PL   +A+
Sbjct: 743 KWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSAD 788



 Score =  158 bits (399), Expect = 3e-38
 Identities = 125/409 (30%), Positives = 180/409 (44%), Gaps = 53/409 (12%)

Query: 27  LIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCS 86
           L+ K  ++N +  E  TPLH A+     +++E+++   A+VNA D+   T LHRA     
Sbjct: 386 LLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGH 445

Query: 87  EEAVQVLLKHSADVNARDKNWQTPLHIAAAN---------------------KAVKCAEA 125
            +  ++LL +  D N       T L +   N                     +A K  + 
Sbjct: 446 LQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDV 505

Query: 126 ----LVPLLSNVNVSDRAGR--TALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHW 179
                +  + +VN  D  GR  T LH AA      +V+ LL  GA+++A DK     +H 
Sbjct: 506 ETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHN 565

Query: 180 AAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYG 239
           A   GH EV +LLV HGA V   D   +TPLH AA+ G   + K LL  G D  + N  G
Sbjct: 566 ACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDG 625

Query: 240 NTPLHVACYNGQDVVVNELIDCGAIVNQKNEKG-----------------------FTPL 276
           NTPL +      D  + +L+   A +    +KG                        TPL
Sbjct: 626 NTPLDLV--KDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPL 683

Query: 277 HFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCED 336
           H AA   +  +  E L+ +GADVN + K G  PLH  A +G    +  +I+  A ++  D
Sbjct: 684 HLAAGYNNLEVA-EYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATD 742

Query: 337 KNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFS 385
           K   TPLH AA+ G   L   L+  GAD   +   G  PL L +    S
Sbjct: 743 KWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVS 791



 Score =  102 bits (254), Expect = 2e-21
 Identities = 88/314 (28%), Positives = 134/314 (42%), Gaps = 69/314 (21%)

Query: 24  VRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVA 83
           V  L+    DV+ +D     PLH A   G  E+ ELL+  GA VN  D    TPLH A A
Sbjct: 542 VEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAA 601

Query: 84  SCSEEAVQVLLKHSAD-------------------------------------------- 99
               E  ++LL+H AD                                            
Sbjct: 602 KGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARV 661

Query: 100 --------VNARDKNWQ--TPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAF 149
                   VN RD   +  TPLH+AA    ++ AE L+   ++VN  D+ G   LH+AA 
Sbjct: 662 KKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAAS 721

Query: 150 SGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTP 209
            GH ++  LL+   A +NA DK     +H AA  G  ++  LL++HGA+ T K+++  TP
Sbjct: 722 YGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTP 781

Query: 210 LHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKN 269
           L   ++  + +++   +        P+A        +CY  Q  V+N +   GA  +  +
Sbjct: 782 LDLVSADDVSALLTAAM-------PPSAL------PSCYKPQ--VLNGVRSPGATADALS 826

Query: 270 EKGFTPLHFAAAST 283
               +P   +AAS+
Sbjct: 827 SGPSSPSSLSAASS 840


>gi|34304381 inversin isoform a [Homo sapiens]
          Length = 1065

 Score =  197 bits (502), Expect = 3e-50
 Identities = 153/486 (31%), Positives = 237/486 (48%), Gaps = 18/486 (3%)

Query: 26  ALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASC 85
           AL+    DVN  D+ +RT LH AA  G+   ++LL+   A    KD + +TPLH      
Sbjct: 66  ALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHR 125

Query: 86  SEEAVQVLLKHSA--DVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTA 143
           S + + +LLK  A  +V+ +DKN QT LH +A     +  + L+   SN+ + D  G+  
Sbjct: 126 SPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIP 185

Query: 144 LHHAAFSGHGE-----MVKLLLSRGAN---INAFDKKDRRAIHWAAYMGHIEVVKLLVSH 195
           LH AA   H +      V+ +L        +N  D + R  +H+A   G++ VV +L S+
Sbjct: 186 LHWAA--NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY 243

Query: 196 -GAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPN-AYGNTPLHVACYNGQDV 253
               +T  D    TPLH AA  G   +V  LL+       P+ + G TPLH A  +    
Sbjct: 244 ESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAE 303

Query: 254 VVNELIDCGAIVNQKNEKGFTPLHFAAAS-THGALCLELLVGNGADVNMKSKDGKTPLHM 312
            V   +   ++ +  + +G T   +AA   +   L   L + +  D+NM  K G T LH 
Sbjct: 304 TVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHA 363

Query: 313 TALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHG 372
            AL G  S  + ++++ A +D  D   +TPL  A   GH+ +I TLI  GA        G
Sbjct: 364 AALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDG 423

Query: 373 MFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFN 432
              LH AAL G +D C+ L+ +  + +  D  GRT L  AA GG + C+ +L+   AD N
Sbjct: 424 HSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPN 483

Query: 433 KKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLD--ERGCTPLHYAATSDTDGKCLEY 490
            +DK GR+ LH++  N     +  L+   A  N ++  E   TPL YA   +   + +++
Sbjct: 484 IQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERH-EVIQF 542

Query: 491 LLRNDA 496
           +L + A
Sbjct: 543 MLEHGA 548



 Score =  196 bits (498), Expect = 1e-49
 Identities = 155/560 (27%), Positives = 266/560 (47%), Gaps = 36/560 (6%)

Query: 276 LHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCE 335
           +H AA +        L+VGN A  + + + G+TPL    L  R   +  ++++GA ++  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 336 DKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLS-- 393
           D +  T LH+AA+ G+   +  L+T  A+  ++ +  M PLHL        C   LL   
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 394 SGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA------A 447
           +  ++DT D   +T LH +A   N E + LL+   ++    D  G+ PLH+AA      A
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197

Query: 448 NCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDA-NPGIRDKQGY 506
               +C+     + + +N  D  G TPLH+ A +D +   ++ L   ++ N    D    
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHF-AVADGNVTVVDVLTSYESCNITSYDNLFR 256

Query: 507 NAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQAL 566
             +H++A  GH   + L+            SGT + SDS      +PLH AA     + +
Sbjct: 257 TPLHWAALLGHAQIVHLLLER-------NKSGT-IPSDSQG---ATPLHYAAQSNFAETV 305

Query: 567 EVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI---LVKDYILKRTPIHA 623
           +V ++     D  +  GRT    AA KG  + +  +++  + I   +   Y    T +HA
Sbjct: 306 KVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKY--GGTALHA 363

Query: 624 AATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKD 683
           AA +GH   ++LL+ N    +A D+      TPL  +   GH D + +L+  GA VD  D
Sbjct: 364 AALSGHVSTVKLLLENNAQVDATDVMK---HTPLFRACEMGHKDVIQTLIKGGARVDLVD 420

Query: 684 KWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAA 743
           + G + LH  A+ G+ +    L+++     ++D  GRTP+  +A  G+I  +  L+++  
Sbjct: 421 QDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMEN-- 478

Query: 744 SMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGN---AFSPLHCAVINDN 800
             +A+P   D  G TALHW+C NG+   ++LLL+   F     N    ++PL  A++ + 
Sbjct: 479 --NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGER 536

Query: 801 EGAAEMLIDTLGASIVNATD 820
               + +++    SI    D
Sbjct: 537 HEVIQFMLEHGALSIAAIQD 556



 Score =  194 bits (492), Expect = 5e-49
 Identities = 146/554 (26%), Positives = 261/554 (47%), Gaps = 54/554 (9%)

Query: 343 LHIAARYGHELLINTLIT-SGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTP 401
           +H AA  G +  +  LI  + A   K    G  PL    L+   DC   LL +G D++  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 402 DDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSG 461
           D   RT LH AA  GN   + LLL   A++ +KD    +PLH    + + +CL  L+   
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 462 A--SVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRL 519
           A   V+  D+   T LH++A  +   + ++ L+++D+N GI D +G   +H++A +    
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNP-EHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPS 196

Query: 520 CLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQ-SLLDLDV 578
            +  +        +++ + T+ L +  +    +PLH A   G+   ++VL      ++  
Sbjct: 197 AVHTVRC------ILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITS 250

Query: 579 RNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIG 638
            ++  RTPL  AA  GH + V +L+ +  S  +       TP+H AA +  +E +++ + 
Sbjct: 251 YDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLK 310

Query: 639 NAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAK--DKWGRTALHRGAVT 696
           +   ++  D++   G+T  M +   G  D + ++L+  +++D    DK+G TALH  A++
Sbjct: 311 HPSVKDDSDLE---GRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALS 367

Query: 697 GHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHG 756
           GH   V  LL++ A+    D    TP+  +   GH  V+  L++  A +D      D  G
Sbjct: 368 GHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDL----VDQDG 423

Query: 757 YTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIV 816
           ++ LHWA   G+    ++L+E         N  +P                         
Sbjct: 424 HSLLHWAALGGNADVCQILIE---------NKINP------------------------- 449

Query: 817 NATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLV 876
           N  D  GRTPL  AA+  ++ C+ +L+ +NA  N  D  G+T L  +  NG  + +++L+
Sbjct: 450 NVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509

Query: 877 SSASAELTLQDNSK 890
             A+    +++N +
Sbjct: 510 DFAAFPNQMENNEE 523



 Score =  190 bits (483), Expect = 5e-48
 Identities = 157/554 (28%), Positives = 248/554 (44%), Gaps = 23/554 (4%)

Query: 30  KKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW-LTPLHRAVASCSEE 88
           K E++ F  +   + +HAAA  GD   ++ LI+  + +  K+ ++  TPL   V +   +
Sbjct: 3   KSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLD 62

Query: 89  AVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAA 148
               LLK  ADVN  D + +T LH+AA     +  + L+   +N    D    T LH   
Sbjct: 63  CADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTT 122

Query: 149 FSGHGEMVKLLLSRGA--NINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS 206
                + + LLL   A   ++  DK  + A+HW+AY  + E VKLL+ H + +   D + 
Sbjct: 123 RHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEG 182

Query: 207 YTPLHAAAS---SGMISVVKYLLDLGVD---MNEPNAYGNTPLHVACYNGQDVVVNELID 260
             PLH AA+      +  V+ +LD       +N  +  G TPLH A  +G   VV+ L  
Sbjct: 183 KIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTS 242

Query: 261 CGAIVNQKNEKGF-TPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRF 319
             +      +  F TPLH+AA   H  +   LL  N +        G TPLH  A     
Sbjct: 243 YESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFA 302

Query: 320 SRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLIT--SGADTAKRGIHGMFPLH 377
              +  ++  +V D  D  G T    AA  G + ++ T+++  S  D      +G   LH
Sbjct: 303 ETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALH 362

Query: 378 LAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKF 437
            AALSG     + LL +   +D  D    T L  A   G+ + +  L+  GA  +  D+ 
Sbjct: 363 AAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQD 422

Query: 438 GRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDAN 497
           G S LH+AA   N      L+ +  + N  D  G TPL  AA       C+  L+ N+A+
Sbjct: 423 GHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYI-NCMAVLMENNAD 481

Query: 498 PGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLA 557
           P I+DK+G  A+H+S   G+   ++L+         ME          +N    +PL  A
Sbjct: 482 PNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQME----------NNEERYTPLDYA 531

Query: 558 AYHGHHQALEVLVQ 571
                H+ ++ +++
Sbjct: 532 LLGERHEVIQFMLE 545



 Score =  187 bits (475), Expect = 4e-47
 Identities = 179/597 (29%), Positives = 261/597 (43%), Gaps = 73/597 (12%)

Query: 376 LHLAALSGFSDCCRKLLSSGFDI-DTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKK 434
           +H AA++G     ++L+     + D  D FGRT L        L+C + LL  GAD NK 
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 435 DKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRN 494
           D   R+ LH AA   NY+ +  L+   A+    D    TPLH   T     KCL  LL+ 
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLT-TRHRSPKCLALLLKF 136

Query: 495 DANPG---IRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATI 551
            A PG    +DK    A+H+SA Y +   ++L+        + +  G             
Sbjct: 137 MA-PGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGK------------ 183

Query: 552 SPLHLAAYHGHHQALEVLVQSLLD-------LDVRNSSGRTPLDLAAFKGHVECVDVLIN 604
            PLH AA H    A+   V+ +LD       L+ ++  GRTPL  A   G+V  VDVL +
Sbjct: 184 IPLHWAANHKDPSAVHT-VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTS 242

Query: 605 QGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNG 664
             +  +     L RTP+H AA                                    L G
Sbjct: 243 YESCNITSYDNLFRTPLHWAA------------------------------------LLG 266

Query: 665 HTDCVYSLL--NKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTP 722
           H   V+ LL  NK   + + D  G T LH  A +   E V   L+H +     D  GRT 
Sbjct: 267 HAQIVHLLLERNKSGTIPS-DSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTS 325

Query: 723 IHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV-F 781
              +A  G   VL  +L   + +D N   AD +G TALH A  +GH + V+LLLE     
Sbjct: 326 FMWAAGKGSDDVLRTMLSLKSDIDIN--MADKYGGTALHAAALSGHVSTVKLLLENNAQV 383

Query: 782 QKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQL 841
             T+    +PL  A    ++   + LI   G + V+  D  G + LH AA   + +  Q+
Sbjct: 384 DATDVMKHTPLFRACEMGHKDVIQTLIK--GGARVDLVDQDGHSLLHWAALGGNADVCQI 441

Query: 842 LLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKG 901
           L+ +    N  D  G+TPL  AA  G  N + +L+ + +A+  +QD    TALH +C+ G
Sbjct: 442 LIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMEN-NADPNIQDKEGRTALHWSCNNG 500

Query: 902 HETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGA-SVLAVDE 957
           +  +  L+L+     N +   N    TPL  A       V+Q +L  GA S+ A+ +
Sbjct: 501 YLDAIKLLLDFAAFPNQME-NNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQD 556



 Score =  150 bits (378), Expect = 8e-36
 Identities = 138/490 (28%), Positives = 214/490 (43%), Gaps = 63/490 (12%)

Query: 538 GTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVE 597
           G   L D +++   +PL            + L+++  D++  + S RT L LAA KG+  
Sbjct: 36  GNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYR 95

Query: 598 CVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPL 657
            + +L+ + A+ + KD + + TP+H    +   +CL LL+    P   VD QD N QT L
Sbjct: 96  FMKLLLTRRANWMQKD-LEEMTPLHLTTRHRSPKCLALLLKFMAP-GEVDTQDKNKQTAL 153

Query: 658 MLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLL--- 714
             S    + + V  L+   +N+   D  G+  LH  A   H+   D    H  +C+L   
Sbjct: 154 HWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAA--NHK---DPSAVHTVRCILDAA 208

Query: 715 --------RDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYN 766
                   +D  GRTP+H + A G++ V+  L    +    N  + DN   T LHWA   
Sbjct: 209 PTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYES---CNITSYDNLFRTPLHWAALL 265

Query: 767 GHETCVELLLEQEVFQK--TEGNAFSPLHCAVIND------------------------- 799
           GH   V LLLE+       ++    +PLH A  ++                         
Sbjct: 266 GHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTS 325

Query: 800 -----NEGAAEMLIDTLGASI---VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNS 851
                 +G+ ++L   L       +N  D  G T LHAAA + HV  ++LLL +NAQV++
Sbjct: 326 FMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDA 385

Query: 852 VDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGH-ETSALLIL 910
            D    TPL  A E G  + ++ L+    A + L D   ++ LH A   G+ +   +LI 
Sbjct: 386 TDVMKHTPLFRACEMGHKDVIQTLI-KGGARVDLVDQDGHSLLHWAALGGNADVCQILIE 444

Query: 911 EKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNK 970
            KI      N  + A +TPL  AA  G    +  L+   A     D+ G T AL  + N 
Sbjct: 445 NKINP----NVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRT-ALHWSCNN 499

Query: 971 DVADCLALIL 980
              D + L+L
Sbjct: 500 GYLDAIKLLL 509



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 57/189 (30%), Positives = 96/189 (50%), Gaps = 2/189 (1%)

Query: 11  SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
           +L  A  +G    V+ L+     V+  D  K TPL  A  +G  ++I+ LI  GARV+  
Sbjct: 360 ALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLV 419

Query: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
           D    + LH A    + +  Q+L+++  + N +D   +TPL  AA    + C   L+   
Sbjct: 420 DQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENN 479

Query: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR--AIHWAAYMGHIEV 188
           ++ N+ D+ GRTALH +  +G+ + +KLLL   A  N  +  + R   + +A      EV
Sbjct: 480 ADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEV 539

Query: 189 VKLLVSHGA 197
           ++ ++ HGA
Sbjct: 540 IQFMLEHGA 548



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 50/182 (27%), Positives = 85/182 (46%), Gaps = 3/182 (1%)

Query: 790 SPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQV 849
           S +H A +N ++GA + LI    +++ +  D  GRTPL      D ++C   LL   A V
Sbjct: 16  SQVHAAAVNGDKGALQRLI-VGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADV 74

Query: 850 NSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLI 909
           N  D + +T L +AA+ G    +++L+ +  A    +D  + T LHL  ++      L +
Sbjct: 75  NKTDHSQRTALHLAAQKGNYRFMKLLL-TRRANWMQKDLEEMTPLHLT-TRHRSPKCLAL 132

Query: 910 LEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPN 969
           L K      ++  +   QT LH +A       V+ L+   +++   D  G  P    A +
Sbjct: 133 LLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANH 192

Query: 970 KD 971
           KD
Sbjct: 193 KD 194


>gi|34304379 inversin isoform b [Homo sapiens]
          Length = 895

 Score =  197 bits (502), Expect = 3e-50
 Identities = 153/486 (31%), Positives = 237/486 (48%), Gaps = 18/486 (3%)

Query: 26  ALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASC 85
           AL+    DVN  D+ +RT LH AA  G+   ++LL+   A    KD + +TPLH      
Sbjct: 66  ALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHR 125

Query: 86  SEEAVQVLLKHSA--DVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTA 143
           S + + +LLK  A  +V+ +DKN QT LH +A     +  + L+   SN+ + D  G+  
Sbjct: 126 SPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIP 185

Query: 144 LHHAAFSGHGE-----MVKLLLSRGAN---INAFDKKDRRAIHWAAYMGHIEVVKLLVSH 195
           LH AA   H +      V+ +L        +N  D + R  +H+A   G++ VV +L S+
Sbjct: 186 LHWAA--NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY 243

Query: 196 -GAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPN-AYGNTPLHVACYNGQDV 253
               +T  D    TPLH AA  G   +V  LL+       P+ + G TPLH A  +    
Sbjct: 244 ESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAE 303

Query: 254 VVNELIDCGAIVNQKNEKGFTPLHFAAAS-THGALCLELLVGNGADVNMKSKDGKTPLHM 312
            V   +   ++ +  + +G T   +AA   +   L   L + +  D+NM  K G T LH 
Sbjct: 304 TVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHA 363

Query: 313 TALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHG 372
            AL G  S  + ++++ A +D  D   +TPL  A   GH+ +I TLI  GA        G
Sbjct: 364 AALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDG 423

Query: 373 MFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFN 432
              LH AAL G +D C+ L+ +  + +  D  GRT L  AA GG + C+ +L+   AD N
Sbjct: 424 HSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPN 483

Query: 433 KKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLD--ERGCTPLHYAATSDTDGKCLEY 490
            +DK GR+ LH++  N     +  L+   A  N ++  E   TPL YA   +   + +++
Sbjct: 484 IQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERH-EVIQF 542

Query: 491 LLRNDA 496
           +L + A
Sbjct: 543 MLEHGA 548



 Score =  196 bits (498), Expect = 1e-49
 Identities = 155/560 (27%), Positives = 266/560 (47%), Gaps = 36/560 (6%)

Query: 276 LHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCE 335
           +H AA +        L+VGN A  + + + G+TPL    L  R   +  ++++GA ++  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 336 DKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLS-- 393
           D +  T LH+AA+ G+   +  L+T  A+  ++ +  M PLHL        C   LL   
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 394 SGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA------A 447
           +  ++DT D   +T LH +A   N E + LL+   ++    D  G+ PLH+AA      A
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197

Query: 448 NCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDA-NPGIRDKQGY 506
               +C+     + + +N  D  G TPLH+ A +D +   ++ L   ++ N    D    
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHF-AVADGNVTVVDVLTSYESCNITSYDNLFR 256

Query: 507 NAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQAL 566
             +H++A  GH   + L+            SGT + SDS      +PLH AA     + +
Sbjct: 257 TPLHWAALLGHAQIVHLLLER-------NKSGT-IPSDSQG---ATPLHYAAQSNFAETV 305

Query: 567 EVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI---LVKDYILKRTPIHA 623
           +V ++     D  +  GRT    AA KG  + +  +++  + I   +   Y    T +HA
Sbjct: 306 KVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKY--GGTALHA 363

Query: 624 AATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKD 683
           AA +GH   ++LL+ N    +A D+      TPL  +   GH D + +L+  GA VD  D
Sbjct: 364 AALSGHVSTVKLLLENNAQVDATDVMK---HTPLFRACEMGHKDVIQTLIKGGARVDLVD 420

Query: 684 KWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAA 743
           + G + LH  A+ G+ +    L+++     ++D  GRTP+  +A  G+I  +  L+++  
Sbjct: 421 QDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMEN-- 478

Query: 744 SMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGN---AFSPLHCAVINDN 800
             +A+P   D  G TALHW+C NG+   ++LLL+   F     N    ++PL  A++ + 
Sbjct: 479 --NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGER 536

Query: 801 EGAAEMLIDTLGASIVNATD 820
               + +++    SI    D
Sbjct: 537 HEVIQFMLEHGALSIAAIQD 556



 Score =  194 bits (492), Expect = 5e-49
 Identities = 146/554 (26%), Positives = 261/554 (47%), Gaps = 54/554 (9%)

Query: 343 LHIAARYGHELLINTLIT-SGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTP 401
           +H AA  G +  +  LI  + A   K    G  PL    L+   DC   LL +G D++  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 402 DDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSG 461
           D   RT LH AA  GN   + LLL   A++ +KD    +PLH    + + +CL  L+   
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 462 A--SVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRL 519
           A   V+  D+   T LH++A  +   + ++ L+++D+N GI D +G   +H++A +    
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNP-EHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPS 196

Query: 520 CLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQ-SLLDLDV 578
            +  +        +++ + T+ L +  +    +PLH A   G+   ++VL      ++  
Sbjct: 197 AVHTVRC------ILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITS 250

Query: 579 RNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIG 638
            ++  RTPL  AA  GH + V +L+ +  S  +       TP+H AA +  +E +++ + 
Sbjct: 251 YDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLK 310

Query: 639 NAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAK--DKWGRTALHRGAVT 696
           +   ++  D++   G+T  M +   G  D + ++L+  +++D    DK+G TALH  A++
Sbjct: 311 HPSVKDDSDLE---GRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALS 367

Query: 697 GHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHG 756
           GH   V  LL++ A+    D    TP+  +   GH  V+  L++  A +D      D  G
Sbjct: 368 GHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDL----VDQDG 423

Query: 757 YTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIV 816
           ++ LHWA   G+    ++L+E         N  +P                         
Sbjct: 424 HSLLHWAALGGNADVCQILIE---------NKINP------------------------- 449

Query: 817 NATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLV 876
           N  D  GRTPL  AA+  ++ C+ +L+ +NA  N  D  G+T L  +  NG  + +++L+
Sbjct: 450 NVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509

Query: 877 SSASAELTLQDNSK 890
             A+    +++N +
Sbjct: 510 DFAAFPNQMENNEE 523



 Score =  190 bits (483), Expect = 5e-48
 Identities = 157/554 (28%), Positives = 248/554 (44%), Gaps = 23/554 (4%)

Query: 30  KKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW-LTPLHRAVASCSEE 88
           K E++ F  +   + +HAAA  GD   ++ LI+  + +  K+ ++  TPL   V +   +
Sbjct: 3   KSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLD 62

Query: 89  AVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAA 148
               LLK  ADVN  D + +T LH+AA     +  + L+   +N    D    T LH   
Sbjct: 63  CADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTT 122

Query: 149 FSGHGEMVKLLLSRGA--NINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS 206
                + + LLL   A   ++  DK  + A+HW+AY  + E VKLL+ H + +   D + 
Sbjct: 123 RHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEG 182

Query: 207 YTPLHAAAS---SGMISVVKYLLDLGVD---MNEPNAYGNTPLHVACYNGQDVVVNELID 260
             PLH AA+      +  V+ +LD       +N  +  G TPLH A  +G   VV+ L  
Sbjct: 183 KIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTS 242

Query: 261 CGAIVNQKNEKGF-TPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRF 319
             +      +  F TPLH+AA   H  +   LL  N +        G TPLH  A     
Sbjct: 243 YESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFA 302

Query: 320 SRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLIT--SGADTAKRGIHGMFPLH 377
              +  ++  +V D  D  G T    AA  G + ++ T+++  S  D      +G   LH
Sbjct: 303 ETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALH 362

Query: 378 LAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKF 437
            AALSG     + LL +   +D  D    T L  A   G+ + +  L+  GA  +  D+ 
Sbjct: 363 AAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQD 422

Query: 438 GRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDAN 497
           G S LH+AA   N      L+ +  + N  D  G TPL  AA       C+  L+ N+A+
Sbjct: 423 GHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYI-NCMAVLMENNAD 481

Query: 498 PGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLA 557
           P I+DK+G  A+H+S   G+   ++L+         ME          +N    +PL  A
Sbjct: 482 PNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQME----------NNEERYTPLDYA 531

Query: 558 AYHGHHQALEVLVQ 571
                H+ ++ +++
Sbjct: 532 LLGERHEVIQFMLE 545



 Score =  187 bits (475), Expect = 4e-47
 Identities = 179/597 (29%), Positives = 261/597 (43%), Gaps = 73/597 (12%)

Query: 376 LHLAALSGFSDCCRKLLSSGFDI-DTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKK 434
           +H AA++G     ++L+     + D  D FGRT L        L+C + LL  GAD NK 
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 435 DKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRN 494
           D   R+ LH AA   NY+ +  L+   A+    D    TPLH   T     KCL  LL+ 
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLT-TRHRSPKCLALLLKF 136

Query: 495 DANPG---IRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATI 551
            A PG    +DK    A+H+SA Y +   ++L+        + +  G             
Sbjct: 137 MA-PGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGK------------ 183

Query: 552 SPLHLAAYHGHHQALEVLVQSLLD-------LDVRNSSGRTPLDLAAFKGHVECVDVLIN 604
            PLH AA H    A+   V+ +LD       L+ ++  GRTPL  A   G+V  VDVL +
Sbjct: 184 IPLHWAANHKDPSAVHT-VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTS 242

Query: 605 QGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNG 664
             +  +     L RTP+H AA                                    L G
Sbjct: 243 YESCNITSYDNLFRTPLHWAA------------------------------------LLG 266

Query: 665 HTDCVYSLL--NKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTP 722
           H   V+ LL  NK   + + D  G T LH  A +   E V   L+H +     D  GRT 
Sbjct: 267 HAQIVHLLLERNKSGTIPS-DSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTS 325

Query: 723 IHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV-F 781
              +A  G   VL  +L   + +D N   AD +G TALH A  +GH + V+LLLE     
Sbjct: 326 FMWAAGKGSDDVLRTMLSLKSDIDIN--MADKYGGTALHAAALSGHVSTVKLLLENNAQV 383

Query: 782 QKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQL 841
             T+    +PL  A    ++   + LI   G + V+  D  G + LH AA   + +  Q+
Sbjct: 384 DATDVMKHTPLFRACEMGHKDVIQTLIK--GGARVDLVDQDGHSLLHWAALGGNADVCQI 441

Query: 842 LLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKG 901
           L+ +    N  D  G+TPL  AA  G  N + +L+ + +A+  +QD    TALH +C+ G
Sbjct: 442 LIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMEN-NADPNIQDKEGRTALHWSCNNG 500

Query: 902 HETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGA-SVLAVDE 957
           +  +  L+L+     N +   N    TPL  A       V+Q +L  GA S+ A+ +
Sbjct: 501 YLDAIKLLLDFAAFPNQME-NNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQD 556



 Score =  150 bits (378), Expect = 8e-36
 Identities = 138/490 (28%), Positives = 214/490 (43%), Gaps = 63/490 (12%)

Query: 538 GTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVE 597
           G   L D +++   +PL            + L+++  D++  + S RT L LAA KG+  
Sbjct: 36  GNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYR 95

Query: 598 CVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPL 657
            + +L+ + A+ + KD + + TP+H    +   +CL LL+    P   VD QD N QT L
Sbjct: 96  FMKLLLTRRANWMQKD-LEEMTPLHLTTRHRSPKCLALLLKFMAP-GEVDTQDKNKQTAL 153

Query: 658 MLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLL--- 714
             S    + + V  L+   +N+   D  G+  LH  A   H+   D    H  +C+L   
Sbjct: 154 HWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAA--NHK---DPSAVHTVRCILDAA 208

Query: 715 --------RDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYN 766
                   +D  GRTP+H + A G++ V+  L    +    N  + DN   T LHWA   
Sbjct: 209 PTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYES---CNITSYDNLFRTPLHWAALL 265

Query: 767 GHETCVELLLEQEVFQK--TEGNAFSPLHCAVIND------------------------- 799
           GH   V LLLE+       ++    +PLH A  ++                         
Sbjct: 266 GHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTS 325

Query: 800 -----NEGAAEMLIDTLGASI---VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNS 851
                 +G+ ++L   L       +N  D  G T LHAAA + HV  ++LLL +NAQV++
Sbjct: 326 FMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDA 385

Query: 852 VDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGH-ETSALLIL 910
            D    TPL  A E G  + ++ L+    A + L D   ++ LH A   G+ +   +LI 
Sbjct: 386 TDVMKHTPLFRACEMGHKDVIQTLI-KGGARVDLVDQDGHSLLHWAALGGNADVCQILIE 444

Query: 911 EKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNK 970
            KI      N  + A +TPL  AA  G    +  L+   A     D+ G T AL  + N 
Sbjct: 445 NKINP----NVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRT-ALHWSCNN 499

Query: 971 DVADCLALIL 980
              D + L+L
Sbjct: 500 GYLDAIKLLL 509



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 57/189 (30%), Positives = 96/189 (50%), Gaps = 2/189 (1%)

Query: 11  SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
           +L  A  +G    V+ L+     V+  D  K TPL  A  +G  ++I+ LI  GARV+  
Sbjct: 360 ALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLV 419

Query: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
           D    + LH A    + +  Q+L+++  + N +D   +TPL  AA    + C   L+   
Sbjct: 420 DQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENN 479

Query: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR--AIHWAAYMGHIEV 188
           ++ N+ D+ GRTALH +  +G+ + +KLLL   A  N  +  + R   + +A      EV
Sbjct: 480 ADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEV 539

Query: 189 VKLLVSHGA 197
           ++ ++ HGA
Sbjct: 540 IQFMLEHGA 548



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 50/182 (27%), Positives = 85/182 (46%), Gaps = 3/182 (1%)

Query: 790 SPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQV 849
           S +H A +N ++GA + LI    +++ +  D  GRTPL      D ++C   LL   A V
Sbjct: 16  SQVHAAAVNGDKGALQRLI-VGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADV 74

Query: 850 NSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLI 909
           N  D + +T L +AA+ G    +++L+ +  A    +D  + T LHL  ++      L +
Sbjct: 75  NKTDHSQRTALHLAAQKGNYRFMKLLL-TRRANWMQKDLEEMTPLHLT-TRHRSPKCLAL 132

Query: 910 LEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPN 969
           L K      ++  +   QT LH +A       V+ L+   +++   D  G  P    A +
Sbjct: 133 LLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANH 192

Query: 970 KD 971
           KD
Sbjct: 193 KD 194


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  194 bits (492), Expect = 5e-49
 Identities = 126/357 (35%), Positives = 176/357 (49%), Gaps = 3/357 (0%)

Query: 177 IHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPN 236
           +H+    G +E V+LL++H  +V C+    YTPL  AA      +   LL  G D N  +
Sbjct: 366 LHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVD 425

Query: 237 AYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNG 296
             G  PLH A  NG D     L+D GA V+ +  +G+TPLH AA +    +   LLV   
Sbjct: 426 EDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVA-RLLVSRQ 484

Query: 297 ADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLIN 356
           AD N+   +GKTPLH+ A  G  S  + +   GA +D + +N  TPLH+A   G    I 
Sbjct: 485 ADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQ 544

Query: 357 TLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGG 416
            L+ SGA        G  PLH AA  G    C+ LL  G  ++ P   G T LH AA  G
Sbjct: 545 HLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKG 604

Query: 417 NLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLH 476
           +LE ++LL  + A+         +PLH AA +     + AL+  GA  N  ++ G TPLH
Sbjct: 605 HLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLH 664

Query: 477 YAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQ-LIASETPLDV 532
            A    T    +  LL + AN   R+K G+   H +A  G+   L+ L+ +   LDV
Sbjct: 665 LAVQRSTFLSVIN-LLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720



 Score =  191 bits (486), Expect = 2e-48
 Identities = 120/367 (32%), Positives = 182/367 (49%), Gaps = 1/367 (0%)

Query: 16  IFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWL 75
           +  G  ++VR L+  + DV+ Q     TPL  AA     ++  LL+  GA  N  D    
Sbjct: 370 VAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGW 429

Query: 76  TPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNV 135
            PLH A  +  +   ++LL H A V+A+++   TPLH+AA N     A  LV   ++ N+
Sbjct: 430 APLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNL 489

Query: 136 SDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSH 195
            +  G+T LH AA+ GH  +VKLL S+GA ++A  +  R  +H A   G +  ++ L+  
Sbjct: 490 HEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKS 549

Query: 196 GAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVV 255
           GA     D+  Y PLH AA+ G   + K LL  G  +  P   G TPLH+A Y G   ++
Sbjct: 550 GAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEII 609

Query: 256 NELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTAL 315
           + L +  A +       +TPLH AA     A+ +  L+  GAD N   + G TPLH+   
Sbjct: 610 HLLAESHANMGALGAVNWTPLHLAARHGEEAV-VSALLQCGADPNAAEQSGWTPLHLAVQ 668

Query: 316 HGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFP 375
              F     +++  A +   +K G TP H+AA  G+  ++  L+ +GA    +      P
Sbjct: 669 RSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTP 728

Query: 376 LHLAALS 382
           L LA  S
Sbjct: 729 LQLALRS 735



 Score =  190 bits (482), Expect = 7e-48
 Identities = 124/386 (32%), Positives = 192/386 (49%), Gaps = 2/386 (0%)

Query: 27  LIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCS 86
           L+ + E++   +N K TPLH     G  E + LL+     V+ + +   TPL  A     
Sbjct: 349 LVPRDEELCIYEN-KVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQ 407

Query: 87  EEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHH 146
            +   +LL H AD N  D++   PLH AA N     A  L+   + V+  +R G T LH 
Sbjct: 408 PDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHL 467

Query: 147 AAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS 206
           AA +    + +LL+SR A+ N  + + +  +H AAY GH+ +VKLL S GAE+  + +  
Sbjct: 468 AAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNL 527

Query: 207 YTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVN 266
            TPLH A   G +  +++LL  G   +  +  G  PLH A   G+ ++   L+  GA + 
Sbjct: 528 RTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLE 587

Query: 267 QKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTII 326
               +G+TPLH AA   H  + + LL  + A++        TPLH+ A HG  +    ++
Sbjct: 588 LPTHQGWTPLHLAAYKGHLEI-IHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALL 646

Query: 327 QSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSD 386
           Q GA  +  +++G TPLH+A +    L +  L+   A+   R   G  P HLAAL G + 
Sbjct: 647 QCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTA 706

Query: 387 CCRKLLSSGFDIDTPDDFGRTCLHAA 412
             + L+ +G  +D  D    T L  A
Sbjct: 707 ILKVLVEAGAQLDVQDGVSCTPLQLA 732



 Score =  186 bits (471), Expect = 1e-46
 Identities = 126/393 (32%), Positives = 190/393 (48%), Gaps = 1/393 (0%)

Query: 75  LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVN 134
           +TPLH  VA  S E V++LL H  DV+ +  +  TPL IAA ++       L+   ++ N
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422

Query: 135 VSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVS 194
             D  G   LH AA +G     +LLL  GA ++A +++    +H AA      V +LLVS
Sbjct: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVS 482

Query: 195 HGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVV 254
             A+    + +  TPLH AA  G +S+VK L   G +++       TPLH+A   G+   
Sbjct: 483 RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRA 542

Query: 255 VNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTA 314
           +  L+  GA+ +  ++ G+ PLH AAA     +C ++L+  GA + + +  G TPLH+ A
Sbjct: 543 IQHLLKSGAVPDALDQSGYGPLHTAAARGKYLIC-KMLLRYGASLELPTHQGWTPLHLAA 601

Query: 315 LHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMF 374
             G       + +S A +        TPLH+AAR+G E +++ L+  GAD       G  
Sbjct: 602 YKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWT 661

Query: 375 PLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKK 434
           PLHLA           LL    ++   +  G T  H AA  GN   L +L+  GA  + +
Sbjct: 662 PLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721

Query: 435 DKFGRSPLHYAAANCNYQCLFALVGSGASVNDL 467
           D    +PL  A  +     +  L G   SV  L
Sbjct: 722 DGVSCTPLQLALRSRKQGIMSFLEGKEPSVATL 754



 Score =  142 bits (358), Expect = 2e-33
 Identities = 119/412 (28%), Positives = 183/412 (44%), Gaps = 46/412 (11%)

Query: 551 ISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASIL 610
           ++PLH     G  + + +L+   +D+D + +SG TPL +AA     +   +L+  GA   
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422

Query: 611 VKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVY 670
             D      P+H AA NG     RLL+ +      VD Q+  G TPL L+  N   +   
Sbjct: 423 RVDED-GWAPLHFAAQNGDDGTARLLLDHGA---CVDAQEREGWTPLHLAAQNNFENVAR 478

Query: 671 SLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACG 730
            L+++ A+ +  +  G+T LH  A  GH   V  L   GA+   +    RTP+HL+   G
Sbjct: 479 LLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERG 538

Query: 731 HIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFS 790
            +  +  LL+S A  DA     D  GY  LH A   G     ++LL              
Sbjct: 539 KVRAIQHLLKSGAVPDA----LDQSGYGPLHTAAARGKYLICKMLLRY------------ 582

Query: 791 PLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVN 850
                                GAS+   T  +G TPLH AA+  H+E + LL   +A + 
Sbjct: 583 ---------------------GASLELPTH-QGWTPLHLAAYKGHLEIIHLLAESHANMG 620

Query: 851 SVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLIL 910
           ++ +   TPL +AA +G+   V  L+    A+    + S  T LHLA  +    S + +L
Sbjct: 621 ALGAVNWTPLHLAARHGEEAVVSALLQ-CGADPNAAEQSGWTPLHLAVQRSTFLSVINLL 679

Query: 911 EKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 962
           E   +   ++A N    TP H+AA  G T +++ L+  GA +   D    TP
Sbjct: 680 EHHAN---VHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTP 728



 Score =  137 bits (344), Expect = 7e-32
 Identities = 115/405 (28%), Positives = 178/405 (43%), Gaps = 17/405 (4%)

Query: 334 CEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLS 393
           C  +N  TPLH     G    +  L+    D   +   G  PL +AA     D C  LL+
Sbjct: 357 CIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLA 416

Query: 394 SGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQC 453
            G D +  D+ G   LH AA  G+     LLL+ GA  + +++ G +PLH AA N     
Sbjct: 417 HGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENV 476

Query: 454 LFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSA 513
              LV   A  N  +  G TPLH AA        ++ L    A    + +     +H + 
Sbjct: 477 ARLLVSRQADPNLHEAEGKTPLHVAAYFG-HVSLVKLLTSQGAELDAQQRNLRTPLHLAV 535

Query: 514 AYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSL 573
             G    +Q +     +   ++ SG              PLH AA  G +   ++L++  
Sbjct: 536 ERGKVRAIQHLLKSGAVPDALDQSG------------YGPLHTAAARGKYLICKMLLRYG 583

Query: 574 LDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECL 633
             L++    G TPL LAA+KGH+E + +L    A++     +   TP+H AA +G    +
Sbjct: 584 ASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAV-NWTPLHLAARHGEEAVV 642

Query: 634 RLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRG 693
             L+      NA    + +G TPL L+V       V +LL   ANV A++K G T  H  
Sbjct: 643 SALLQCGADPNAA---EQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLA 699

Query: 694 AVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGAL 738
           A+ G+   +  L++ GA+  ++D    TP+ L+      G++  L
Sbjct: 700 ALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744



 Score =  135 bits (341), Expect = 2e-31
 Identities = 115/369 (31%), Positives = 166/369 (44%), Gaps = 14/369 (3%)

Query: 614 YILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLL 673
           Y  K TP+H     G  E +RLL+ +   +  VD Q  +G TPL+++  +   D    LL
Sbjct: 359 YENKVTPLHFLVAQGSVEQVRLLLAH---EVDVDCQTASGYTPLLIAAQDQQPDLCALLL 415

Query: 674 NKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIG 733
             GA+ +  D+ G   LH  A  G +     LL HGA    ++  G TP+HL+A      
Sbjct: 416 AHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFEN 475

Query: 734 VLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV-FQKTEGNAFSPL 792
           V   L+    S  A+P   +  G T LH A Y GH + V+LL  Q       + N  +PL
Sbjct: 476 VARLLV----SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPL 531

Query: 793 HCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSV 852
           H AV      A + L+ +   ++ +A D  G  PLH AA        ++LL + A +   
Sbjct: 532 HLAVERGKVRAIQHLLKS--GAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELP 589

Query: 853 DSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEK 912
              G TPL +AA  G    + +L  S  A +        T LHLA   G E     +L+ 
Sbjct: 590 THQGWTPLHLAAYKGHLEIIHLLAES-HANMGALGAVNWTPLHLAARHGEEAVVSALLQC 648

Query: 913 ITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDV 972
             D N   A   +  TPLH+A +    + V  LL   A+V A ++ G+TPA   A   + 
Sbjct: 649 GADPN---AAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNT 705

Query: 973 ADCLALILA 981
           A    L+ A
Sbjct: 706 AILKVLVEA 714



 Score =  130 bits (326), Expect = 8e-30
 Identities = 120/419 (28%), Positives = 184/419 (43%), Gaps = 26/419 (6%)

Query: 469 ERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASET 528
           E   TPLH+     +  + +  LL ++ +   +   GY  +  +A             + 
Sbjct: 360 ENKVTPLHFLVAQGSVEQ-VRLLLAHEVDVDCQTASGYTPLLIAAQ----------DQQP 408

Query: 529 PLDVLMETSGTDMLS-DSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPL 587
            L  L+   G D    D D  A   PLH AA +G      +L+     +D +   G TPL
Sbjct: 409 DLCALLLAHGADANRVDEDGWA---PLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPL 465

Query: 588 DLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVD 647
            LAA         +L+++ A   + +   K TP+H AA  GH   ++LL         +D
Sbjct: 466 HLAAQNNFENVARLLVSRQADPNLHEAEGK-TPLHVAAYFGHVSLVKLLTSQGAE---LD 521

Query: 648 IQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQ 707
            Q  N +TPL L+V  G    +  LL  GA  DA D+ G   LH  A  G       LL+
Sbjct: 522 AQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLR 581

Query: 708 HGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNG 767
           +GA   L   +G TP+HL+A  GH+ ++  L +S A+M A  A      +T LH A  +G
Sbjct: 582 YGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAV----NWTPLHLAARHG 637

Query: 768 HETCVELLLEQEVF-QKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTP 826
            E  V  LL+        E + ++PLH AV      +   L++    + V+A +  G TP
Sbjct: 638 EEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLE--HHANVHARNKVGWTP 695

Query: 827 LHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTL 885
            H AA   +   L++L+   AQ++  D    TPL +A  + +   +  L     +  TL
Sbjct: 696 AHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSVATL 754



 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 59/183 (32%), Positives = 91/183 (49%), Gaps = 2/183 (1%)

Query: 44  PLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNAR 103
           PLH AA  G   I ++L+  GA +     +  TPLH A      E + +L +  A++ A 
Sbjct: 563 PLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGAL 622

Query: 104 DK-NWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSR 162
              NW TPLH+AA +       AL+   ++ N ++++G T LH A        V  LL  
Sbjct: 623 GAVNW-TPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEH 681

Query: 163 GANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVV 222
            AN++A +K      H AA  G+  ++K+LV  GA++  +D  S TPL  A  S    ++
Sbjct: 682 HANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIM 741

Query: 223 KYL 225
            +L
Sbjct: 742 SFL 744



 Score = 37.4 bits (85), Expect = 0.075
 Identities = 27/101 (26%), Positives = 47/101 (46%)

Query: 18  NGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTP 77
           +G+   V AL+    D N  +    TPLH A        +  L+   A V+A++    TP
Sbjct: 636 HGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTP 695

Query: 78  LHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANK 118
            H A    +   ++VL++  A ++ +D    TPL +A  ++
Sbjct: 696 AHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSR 736


>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
          Length = 1119

 Score =  182 bits (462), Expect = 1e-45
 Identities = 150/498 (30%), Positives = 240/498 (48%), Gaps = 31/498 (6%)

Query: 32  EDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQ 91
           E ++  D+   TPLH A      E ++ L+  GA  N ++   + PLH AV   + E ++
Sbjct: 89  EVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMK 148

Query: 92  VLLKH-SADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFS 150
           VLL+H + DVN   +N  T + IA      +  + L+   +    S++ G   +H AAFS
Sbjct: 149 VLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFS 208

Query: 151 GHGEMVKLLL--------SRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK 202
           G  E ++++L        SR  +IN  +      +H A   G +E++K+ + +GA++   
Sbjct: 209 GSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPV 268

Query: 203 DKKSYTPLHAAASSGMISVVKYLLDL---GVD-MNEPNAYGNTPLHVACYNGQDVVVNEL 258
           +K   T +H AA+ G   +VK ++      VD +N  +    T LH A       + + L
Sbjct: 269 EKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYL 328

Query: 259 IDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTA---- 314
           I  GA +N+ + +G +PL  A AS    + + LL+  GA V++K   G+  LH+T     
Sbjct: 329 ISVGADINKIDSEGRSPLILATASASWNI-VNLLLSKGAQVDIKDNFGRNFLHLTVQQPY 387

Query: 315 ----LHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGI 370
               L   F + Q I +   V+D ED +G TPLH A R G    +N L+        +  
Sbjct: 388 GLKNLRPEFMQMQQIKE--LVMD-EDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSK 444

Query: 371 HGMFPLHLAALSGFSDCCRKLLSSGFD---IDTPDDFGRTCLHAAAAGGNLECLNLLLNT 427
               PLH AA  G  + C++LL    D   ++  D  G T LH AA  G+ + + LLL  
Sbjct: 445 DKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKK 504

Query: 428 GADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVND-LDERGCTPLHYAATSDTDGK 486
           GA F   D  G + LH+A+     Q +  ++ +     D LDE G T LH+AA  +   K
Sbjct: 505 GALF-LSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAA-REGHAK 562

Query: 487 CLEYLLRNDANPGIRDKQ 504
            +  LL ++A+  +  +Q
Sbjct: 563 AVALLLSHNADIVLNKQQ 580



 Score =  166 bits (419), Expect = 1e-40
 Identities = 163/582 (28%), Positives = 253/582 (43%), Gaps = 55/582 (9%)

Query: 374 FPLHLAALSGFSDCCRKLL--SSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADF 431
           F LH AA  G  +   K+   SS   +   DD+G T LH A     +E +  LL+ GA+ 
Sbjct: 65  FFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANP 124

Query: 432 NKKDKFGRSPLHYAAANCNYQCLFALVGSGA-SVNDLDERGCTPLHYAATSDTDGKCLEY 490
           N ++    +PLH A    N + +  L+      VN   E G T +  A T++ + + L+ 
Sbjct: 125 NLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTN-NSEALQI 183

Query: 491 LLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRAT 550
           LL+  A P   +K G   +H +A  G + C+++I                          
Sbjct: 184 LLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEII-------------------------- 217

Query: 551 ISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASIL 610
              L     HG+ + L +        +  N+   TPL LA   G +E + + ++ GA I 
Sbjct: 218 ---LRFGEEHGYSRQLHI--------NFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQI- 265

Query: 611 VKDYILKR--TPIHAAATNGHSECLRLLIGNAEPQ-NAVDIQDGNGQTPLMLSVLNGHTD 667
             D + K   T IH AAT G +E ++L+I +     + V+  DG  +T L  + L  H +
Sbjct: 266 --DPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHE 323

Query: 668 CVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSA 727
               L++ GA+++  D  GR+ L     +     V+ LL  GA+  ++D+ GR  +HL+ 
Sbjct: 324 LADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTV 383

Query: 728 ACGH-IGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV-FQKTE 785
              + +  L         +       DN G T LH+AC  G    V  LL   V      
Sbjct: 384 QQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKS 443

Query: 786 GNAFSPLHCAVINDNEGAAEMLI-DTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLS 844
            +  SPLH A         + L+ D     ++N  D  G TPLH AA   H + +QLLL 
Sbjct: 444 KDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLK 503

Query: 845 HNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHET 904
             A   S D  G T L  A+  G T T+++++ +        D   NTALH A  +GH  
Sbjct: 504 KGALFLS-DHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAK 562

Query: 905 SALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELL 946
           +  L+L    D  ++N   A+    LH+A  N    VV  ++
Sbjct: 563 AVALLLSHNAD-IVLNKQQASF---LHLALHNKRKEVVLTII 600



 Score =  164 bits (415), Expect = 4e-40
 Identities = 143/531 (26%), Positives = 238/531 (44%), Gaps = 30/531 (5%)

Query: 201 CKDKKSYTPLHAAASSGMISVV-KYLLDLGVD-MNEPNAYGNTPLHVACYNGQDVVVNEL 258
           C D  ++  LH AA+ G I ++ K   D  ++ ++E + YGNTPLH A    Q   V  L
Sbjct: 59  CDDMDTFF-LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFL 117

Query: 259 IDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGR 318
           +  GA  N +N     PLH A    +  +   LL     DVN++ ++G T + +      
Sbjct: 118 LSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNN 177

Query: 319 FSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTA-KRGIHGMF--- 374
               Q +++ GA     +K G  P+H AA  G +  +  ++  G +    R +H  F   
Sbjct: 178 SEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNN 237

Query: 375 ----PLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGAD 430
               PLHLA  +G  +  +  L +G  ID  +    T +H AA  G  E + L++++ + 
Sbjct: 238 GKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSG 297

Query: 431 ----FNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGK 486
                N  D    + LH A+   +++    L+  GA +N +D  G +PL   AT+     
Sbjct: 298 SVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPL-ILATASASWN 356

Query: 487 CLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSD 546
            +  LL   A   I+D  G N +H +    + L           + +      +++ D D
Sbjct: 357 IVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGL------KNLRPEFMQMQQIKELVMDED 410

Query: 547 NRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLIN-- 604
           N    +PLH A   G   ++  L+   + +  ++   ++PL  AA  G +     L+   
Sbjct: 411 NDG-CTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDI 469

Query: 605 QGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNG 664
               +L +  +   TP+H AA NGH + ++LL+     + A+ + D NG T L  + + G
Sbjct: 470 SDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLL----KKGALFLSDHNGWTALHHASMGG 525

Query: 665 HTDCVYSLLNKGAN-VDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLL 714
           +T  +  +L+      D  D+ G TALH  A  GH + V  LL H A  +L
Sbjct: 526 YTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVL 576



 Score =  158 bits (399), Expect = 3e-38
 Identities = 136/501 (27%), Positives = 230/501 (45%), Gaps = 58/501 (11%)

Query: 15  AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGA-RVNAKDSK 73
           A+     + V+ L+ +  + N ++     PLH A    + E++++L+      VN +   
Sbjct: 105 AVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGEN 164

Query: 74  WLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPL---- 129
             T +  A  + + EA+Q+LLK  A     +K    P+H AA + + +C E ++      
Sbjct: 165 GNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEH 224

Query: 130 ----LSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGH 185
                 ++N  +    T LH A  +G  EM+K+ L  GA I+  +K    AIH+AA  G 
Sbjct: 225 GYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGA 284

Query: 186 IEVVKLLVSHGAE----VTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNT 241
            E+VKL++S  +     V   D    T LH A+      +  YL+ +G D+N+ ++ G +
Sbjct: 285 TEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRS 344

Query: 242 PLHVACYNGQDVVVNELIDCGA-------------------------------------- 263
           PL +A  +    +VN L+  GA                                      
Sbjct: 345 PLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKE 404

Query: 264 IVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQ 323
           +V  ++  G TPLH+A     G   +  L+G    ++ KSKD K+PLH  A +GR +  Q
Sbjct: 405 LVMDEDNDGCTPLHYACRQ-GGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQ 463

Query: 324 TIIQ---SGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAA 380
            ++Q      +++  D +G TPLH+AA+ GH+ ++  L+  GA       +G   LH A+
Sbjct: 464 RLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHAS 522

Query: 381 LSGFSDCCRKLLSSGFD-IDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGR 439
           + G++   + +L +     D  D+ G T LH AA  G+ + + LLL+  AD    +K   
Sbjct: 523 MGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQA 581

Query: 440 SPLHYAAANCNYQCLFALVGS 460
           S LH A  N   + +  ++ S
Sbjct: 582 SFLHLALHNKRKEVVLTIIRS 602



 Score =  154 bits (390), Expect = 3e-37
 Identities = 129/461 (27%), Positives = 219/461 (47%), Gaps = 64/461 (13%)

Query: 554 LHLAAYHGHHQALEVLVQ--SLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611
           LH AA  G  + +E + +  SL  L   +  G TPL  A  K  +E V  L+++GA+  +
Sbjct: 67  LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126

Query: 612 KDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYS 671
           +++ +   P+H A    ++E +++L+ +      V+++  NG T ++++    +++ +  
Sbjct: 127 RNFNMM-APLHIAVQGMNNEVMKVLLEHRTID--VNLEGENGNTAVIIACTTNNSEALQI 183

Query: 672 LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALL----QHGAKCLLR----DSRGRTPI 723
           LL KGA     +KWG   +H+ A +G +EC++ +L    +HG    L     ++   TP+
Sbjct: 184 LLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPL 243

Query: 724 HLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQ----- 778
           HL+   G + ++   L + A +D      +    TA+H+A   G    V+L++       
Sbjct: 244 HLAVQNGDLEMIKMCLDNGAQIDP----VEKGRCTAIHFAATQGATEIVKLMISSYSGSV 299

Query: 779 EVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVEC 838
           ++   T+G   + LH A + D+   A+ LI ++GA I N  DS+GR+PL  A  +     
Sbjct: 300 DIVNTTDGCHETMLHRASLFDHHELADYLI-SVGADI-NKIDSEGRSPLILATASASWNI 357

Query: 839 LQLLLSHNAQVNSVDSTGK--------------------------------------TPL 860
           + LLLS  AQV+  D+ G+                                      TPL
Sbjct: 358 VNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPL 417

Query: 861 MMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLIN 920
             A   G   +V  L+   +  +  +   K + LH A S G   +   +L+ I+D  L+N
Sbjct: 418 HYACRQGGPGSVNNLLGF-NVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLN 476

Query: 921 ATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYT 961
             +    TPLH+AA+NG   VVQ LL KGA  L+ D NG+T
Sbjct: 477 EGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLS-DHNGWT 516



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 94/311 (30%), Positives = 141/311 (45%), Gaps = 14/311 (4%)

Query: 34  VNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVL 93
           VN  D    T LH A+     E+ + LI  GA +N  DS+  +PL  A AS S   V +L
Sbjct: 302 VNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLL 361

Query: 94  LKHSADVNARDKNWQTPLHIAAANK-AVKCAE----ALVPLLSNVNVSDRAGRTALHHAA 148
           L   A V+ +D   +  LH+       +K        +  +   V   D  G T LH+A 
Sbjct: 362 LSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYAC 421

Query: 149 FSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLL---VSHGAEVTCKDKK 205
             G    V  LL    +I++  K  +  +H+AA  G I   + L   +S    +   D  
Sbjct: 422 RQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLH 481

Query: 206 SYTPLHAAASSGMISVVKYLLDLG-VDMNEPNAYGNTPLHVACYNGQDVVVNELIDCG-A 263
             TPLH AA +G   VV+ LL  G + +++ N  G T LH A   G    +  ++D    
Sbjct: 482 GMTPLHLAAKNGHDKVVQLLLKKGALFLSDHN--GWTALHHASMGGYTQTMKVILDTNLK 539

Query: 264 IVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQ 323
             ++ +E G T LHFAA   H A  + LL+ + AD+ + +K   + LH+   + R     
Sbjct: 540 CTDRLDEDGNTALHFAAREGH-AKAVALLLSHNADI-VLNKQQASFLHLALHNKRKEVVL 597

Query: 324 TIIQSGAVIDC 334
           TII+S    +C
Sbjct: 598 TIIRSKRWDEC 608


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  182 bits (462), Expect = 1e-45
 Identities = 121/353 (34%), Positives = 178/353 (50%), Gaps = 4/353 (1%)

Query: 12  LVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKD 71
           LV AI +GD  ++  ++ + +DV+   +   + LH A   G  E  + L+L+ A  N  +
Sbjct: 410 LVDAIVSGDTSKLMKIL-QPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSN 468

Query: 72  SKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLS 131
            +  TPLH AV       V++LL     VNA+D++  T LH AA N        L+   +
Sbjct: 469 RRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNA 528

Query: 132 NVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKL 191
           +VN  D  GRT +H A   G   +V++LL RG +++   K     +H+AA+ GH+ +VKL
Sbjct: 529 SVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKL 588

Query: 192 LVSH-GAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 250
           L    G  V  +     TPLH AA  G   V + L+DL  D+N  +    TPLHVA   G
Sbjct: 589 LAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETG 648

Query: 251 QDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPL 310
                  L+  GA        G+T LH AA + H A  ++LLV   ADV  +    +T L
Sbjct: 649 HTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLA-TVKLLVEEKADVLARGPLNQTAL 707

Query: 311 HMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGA 363
           H+ A HG     + ++ S  VID  D+ G + LH+AA+  H   + TL+  GA
Sbjct: 708 HLAAAHGHSEVVEELV-SADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759



 Score =  160 bits (406), Expect = 4e-39
 Identities = 111/369 (30%), Positives = 178/369 (48%), Gaps = 3/369 (0%)

Query: 97  SADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMV 156
           ++D+   D   +  +    +    K  + L P   +V+++  +G + LH A  +G  E  
Sbjct: 397 TSDLGTTDVQKKKLVDAIVSGDTSKLMKILQP--QDVDLALDSGASLLHLAVEAGQEECA 454

Query: 157 KLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASS 216
           K LL   AN N  +++    +H A       VV+LL++    V  KD+  +T LH AA +
Sbjct: 455 KWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQN 514

Query: 217 GMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPL 276
           G  S  + LL+    +NE +  G TP+HVAC +GQ+ +V  L+  G  V+ + +  + PL
Sbjct: 515 GDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPL 574

Query: 277 HFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCED 336
           H+AA   H  +   L    G  VN ++ DG+TPLH+ A  G +  ++ +I   + ++   
Sbjct: 575 HYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCS 634

Query: 337 KNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGF 396
               TPLH+AA  GH      L+  GA        G   LHLAA +G     + L+    
Sbjct: 635 LLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKA 694

Query: 397 DIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFA 456
           D+       +T LH AAA G+ E +  L++     +  D+ G S LH AA   + Q +  
Sbjct: 695 DVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVET 753

Query: 457 LVGSGASVN 465
           L+  GA +N
Sbjct: 754 LLRHGAHIN 762



 Score =  143 bits (361), Expect = 7e-34
 Identities = 113/380 (29%), Positives = 173/380 (45%), Gaps = 23/380 (6%)

Query: 397 DIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFA 456
           D+ T D   +  + A  +G   + + +L     D       G S LH A      +C   
Sbjct: 399 DLGTTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDS--GASLLHLAVEAGQEECAKW 456

Query: 457 LVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYG 516
           L+ + A+ N  + RG TPLH A      G  +E LL    +   +D+  + A+H++A  G
Sbjct: 457 LLLNNANPNLSNRRGSTPLHMAVERRVRG-VVELLLARKISVNAKDEDQWTALHFAAQNG 515

Query: 517 HRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDL 576
                     E+   +L+E + +    D + R   +P+H+A  HG    + +L++  +D+
Sbjct: 516 ---------DESSTRLLLEKNASVNEVDFEGR---TPMHVACQHGQENIVRILLRRGVDV 563

Query: 577 DVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLL 636
            ++      PL  AA++GH+  V +L  Q    +    +  RTP+H AA  GH    R+L
Sbjct: 564 SLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARIL 623

Query: 637 IGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVT 696
           I      N   +     QTPL ++   GHT     LL++GA  +A    G TALH  A  
Sbjct: 624 IDLCSDVNVCSLL---AQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARN 680

Query: 697 GHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHG 756
           GH   V  L++  A  L R    +T +HL+AA GH  V+  L+ SA  +D      D  G
Sbjct: 681 GHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV-SADVID----LFDEQG 735

Query: 757 YTALHWACYNGHETCVELLL 776
            +ALH A    H   VE LL
Sbjct: 736 LSALHLAAQGRHAQTVETLL 755



 Score =  130 bits (327), Expect = 7e-30
 Identities = 107/346 (30%), Positives = 165/346 (47%), Gaps = 16/346 (4%)

Query: 615 ILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLN 674
           + K+  + A  +   S+ +++L    +PQ+ VD+   +G + L L+V  G  +C   LL 
Sbjct: 405 VQKKKLVDAIVSGDTSKLMKIL----QPQD-VDLALDSGASLLHLAVEAGQEECAKWLLL 459

Query: 675 KGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGV 734
             AN +  ++ G T LH          V+ LL        +D    T +H +A  G    
Sbjct: 460 NNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESS 519

Query: 735 LGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEG-NAFSPLH 793
              LL+  AS++      D  G T +H AC +G E  V +LL + V    +G +A+ PLH
Sbjct: 520 TRLLLEKNASVNE----VDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLH 575

Query: 794 CAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVD 853
            A    +    ++L    G S VNA    GRTPLH AA   H    ++L+   + VN   
Sbjct: 576 YAAWQGHLPIVKLLAKQPGVS-VNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCS 634

Query: 854 STGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKI 913
              +TPL +AAE G T+T  +L+   + +  +  +   TALHLA   GH  +  L++E+ 
Sbjct: 635 LLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGY-TALHLAARNGHLATVKLLVEEK 693

Query: 914 TDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENG 959
            D   + A     QT LH+AA +G + VV+EL+      L  DE G
Sbjct: 694 AD---VLARGPLNQTALHLAAAHGHSEVVEELVSADVIDL-FDEQG 735



 Score =  127 bits (319), Expect = 6e-29
 Identities = 106/381 (27%), Positives = 166/381 (43%), Gaps = 54/381 (14%)

Query: 332 IDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKL 391
           +D    +G + LH+A   G E     L+ + A+       G  PLH+A           L
Sbjct: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490

Query: 392 LSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNY 451
           L+    ++  D+   T LH AA  G+     LLL   A  N+ D  GR+P+H A  +   
Sbjct: 491 LARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQE 550

Query: 452 QCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHY 511
             +  L+  G  V+   +    PLHYAA                                
Sbjct: 551 NIVRILLRRGVDVSLQGKDAWLPLHYAAWQ------------------------------ 580

Query: 512 SAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQ 571
               GH   ++L+A +  + V  +T         D R   +PLHLAA  GH++   +L+ 
Sbjct: 581 ----GHLPIVKLLAKQPGVSVNAQT--------LDGR---TPLHLAAQRGHYRVARILID 625

Query: 572 SLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGA--SILVKDYILKRTPIHAAATNGH 629
              D++V +   +TPL +AA  GH     +L+++GA    +  D     T +H AA NGH
Sbjct: 626 LCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSD---GYTALHLAARNGH 682

Query: 630 SECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTA 689
              ++LL+   E +  V  +    QT L L+  +GH++ V  L++    +D  D+ G +A
Sbjct: 683 LATVKLLV---EEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSA 738

Query: 690 LHRGAVTGHEECVDALLQHGA 710
           LH  A   H + V+ LL+HGA
Sbjct: 739 LHLAAQGRHAQTVETLLRHGA 759



 Score =  120 bits (301), Expect = 7e-27
 Identities = 90/306 (29%), Positives = 146/306 (47%), Gaps = 13/306 (4%)

Query: 547 NRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQG 606
           NR   +PLH+A        +E+L+   + ++ ++    T L  AA  G      +L+ + 
Sbjct: 468 NRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKN 527

Query: 607 ASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHT 666
           AS+   D+   RTP+H A  +G    +R+L+        V +Q  +   PL  +   GH 
Sbjct: 528 ASVNEVDFE-GRTPMHVACQHGQENIVRILLRRGVD---VSLQGKDAWLPLHYAAWQGHL 583

Query: 667 DCVYSLLNK-GANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHL 725
             V  L  + G +V+A+   GRT LH  A  GH      L+   +   +     +TP+H+
Sbjct: 584 PIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHV 643

Query: 726 SAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTE 785
           +A  GH      LL   A  +A   T+D  GYTALH A  NGH   V+LL+E++      
Sbjct: 644 AAETGHTSTARLLLHRGAGKEA--MTSD--GYTALHLAARNGHLATVKLLVEEKADVLAR 699

Query: 786 GNAF-SPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLS 844
           G    + LH A  +   G +E++ + + A +++  D +G + LH AA   H + ++ LL 
Sbjct: 700 GPLNQTALHLAAAH---GHSEVVEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLR 756

Query: 845 HNAQVN 850
           H A +N
Sbjct: 757 HGAHIN 762



 Score =  119 bits (299), Expect = 1e-26
 Identities = 96/337 (28%), Positives = 145/337 (43%), Gaps = 43/337 (12%)

Query: 657 LMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRD 716
           L+ ++++G T  +  +L    +VD     G + LH     G EEC   LL + A   L +
Sbjct: 410 LVDAIVSGDTSKLMKILQP-QDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSN 468

Query: 717 SRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLL 776
            RG TP+H++      GV+  LL    S++A     D   +TALH+A  NG E+   LLL
Sbjct: 469 RRGSTPLHMAVERRVRGVVELLLARKISVNAK----DEDQWTALHFAAQNGDESSTRLLL 524

Query: 777 EQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHV 836
           E+                                   + VN  D +GRTP+H A      
Sbjct: 525 EKN----------------------------------ASVNEVDFEGRTPMHVACQHGQE 550

Query: 837 ECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHL 896
             +++LL     V+        PL  AA  G    V++L       +  Q     T LHL
Sbjct: 551 NIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHL 610

Query: 897 ACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVD 956
           A  +GH   A ++++  +D   +N  +   QTPLHVAA  G T   + LL +GA   A+ 
Sbjct: 611 AAQRGHYRVARILIDLCSD---VNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMT 667

Query: 957 ENGYTPALACAPNKDVADCLALILATMMPVSSSSPLS 993
            +GYT     A N  +A  + L++     V +  PL+
Sbjct: 668 SDGYTALHLAARNGHLA-TVKLLVEEKADVLARGPLN 703



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 59/172 (34%), Positives = 85/172 (49%), Gaps = 1/172 (0%)

Query: 34  VNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVL 93
           VN Q  + RTPLH AA  G   +  +LI   + VN       TPLH A  +      ++L
Sbjct: 597 VNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLL 656

Query: 94  LKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHG 153
           L   A   A   +  T LH+AA N  +   + LV   ++V       +TALH AA  GH 
Sbjct: 657 LHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHS 716

Query: 154 EMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKK 205
           E+V+ L+S    I+ FD++   A+H AA   H + V+ L+ HGA +  +  K
Sbjct: 717 EVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLK 767



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 44/159 (27%), Positives = 61/159 (38%), Gaps = 34/159 (21%)

Query: 9   QPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVN 68
           Q  L  A   G     R L+ +        ++  T LH AA  G    ++LL+   A V 
Sbjct: 638 QTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVL 697

Query: 69  AKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVP 128
           A+     T LH A A    E V+ L+  SADV                            
Sbjct: 698 ARGPLNQTALHLAAAHGHSEVVEELV--SADV---------------------------- 727

Query: 129 LLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANIN 167
               +++ D  G +ALH AA   H + V+ LL  GA+IN
Sbjct: 728 ----IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762


>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
           [Homo sapiens]
          Length = 627

 Score =  169 bits (429), Expect = 1e-41
 Identities = 125/399 (31%), Positives = 202/399 (50%), Gaps = 7/399 (1%)

Query: 8   DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
           D  SL +A  +GD + VR L+ +   VN    E  + L  A   G  E+ ++L+   A V
Sbjct: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264

Query: 68  NAKDSKW-LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126
             + +K  +TPL  A +    + V++LL H ADVN++     T L  A A   V   + L
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324

Query: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR-AIHWAAYMGH 185
           +   +N+   +  G T L  AA +GH E+ ++LL  GA IN    + +  A+  A Y GH
Sbjct: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 384

Query: 186 IEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245
           +++V+ L+  GA+   K  + +T L  A   G + V + LLD G  +N P     +PL +
Sbjct: 385 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 444

Query: 246 ACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 305
           A   G   +   LI+ GA + + N++G+TPL  AA   H  + + LL+  GA++N ++++
Sbjct: 445 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM-VALLLAQGANINAQTEE 503

Query: 306 GKTPLHMTALHGRFSR-SQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD 364
            +      A  G FS  +  +I++GA I+      +TPL  A++ GH  L+  L+ SGA+
Sbjct: 504 TQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGAN 560

Query: 365 TAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDD 403
                  G   L  A  +G +D    LL +G D+D  +D
Sbjct: 561 VHATTATGDTALTYACENGHTDVADVLLQAGADLDKQED 599



 Score =  156 bits (394), Expect = 1e-37
 Identities = 122/395 (30%), Positives = 201/395 (50%), Gaps = 17/395 (4%)

Query: 84  SCSE---EAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAG 140
           +CS+    AV+ LL     VN   +  ++ L +A +    + A+ L+ +  + NV DR  
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM--HANVEDRGN 269

Query: 141 R---TALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGA 197
           +   T L  A+  G+ ++VKLLL   A++N+       A+ +A   G +++VK+L++ GA
Sbjct: 270 KGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA 329

Query: 198 EVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN-EPNAYGNTPLHVACYNGQDVVVN 256
            +   ++  +TPL  AAS+G + V + LLD G  +N   N +  + L +ACY G   +V 
Sbjct: 330 NIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVR 389

Query: 257 ELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALH 316
            L++ GA    K ++  T L  A    H  +   LL+ +GA VNM +   ++PL + A  
Sbjct: 390 FLLEAGADQEHKTDEMHTALMEACMDGHVEVA-RLLLDSGAQVNMPADSFESPLTLAACG 448

Query: 317 GRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD-TAKRGIHGMFP 375
           G    +  +I+ GA ++  +  G TPL  AAR GHE ++  L+  GA+  A+        
Sbjct: 449 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA 508

Query: 376 LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKD 435
           L LA   GFS+    L+ +G DI+       T L  A+  G+LE +  LL +GA+ +   
Sbjct: 509 LTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATT 565

Query: 436 KFGRSPLHYAAANCNYQCLFALVGSGASVNDLDER 470
             G + L YA  N +      L+ +GA   DLD++
Sbjct: 566 ATGDTALTYACENGHTDVADVLLQAGA---DLDKQ 597



 Score =  139 bits (349), Expect = 2e-32
 Identities = 134/461 (29%), Positives = 207/461 (44%), Gaps = 25/461 (5%)

Query: 526 SETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQ-ALEVLVQSLLDLDVRNSSGR 584
           ++  L+ L+E +G   LS +D +A   P  L         AL+    +L  +   NS   
Sbjct: 142 TQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNA 201

Query: 585 TPLDL-----AAFKGHVECVDVLINQGASILVKDYILK-RTPIHAAATNGHSECLRLLIG 638
             +D      A   G V  V  L+++G S  V ++  +  + +  A + G+ E  ++L+ 
Sbjct: 202 GQVDTRSLAEACSDGDVNAVRKLLDEGRS--VNEHTEEGESLLCLACSAGYYELAQVLL- 258

Query: 639 NAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGH 698
            A   N  D  +    TPLM +   G+ D V  LL   A+V+++   G TAL      G 
Sbjct: 259 -AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGF 317

Query: 699 EECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYT 758
            + V  LL  GA     +  G TP+  +A+ GH+ V   LL   A ++ +   ++    +
Sbjct: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTH---SNEFKES 374

Query: 759 ALHWACYNGHETCVELLLEQEVFQKTEGNAF-SPLHCAVINDNEGAAEMLIDTLGASIVN 817
           AL  ACY GH   V  LLE    Q+ + +   + L  A ++ +   A +L+D+ GA +  
Sbjct: 375 ALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS-GAQVNM 433

Query: 818 ATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVS 877
             DS   +PL  AA   HVE   LL+   A +  V+  G TPLM AA  G    V +L++
Sbjct: 434 PADS-FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA 492

Query: 878 SASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNG 937
             +      + ++ TAL LAC  G    A  +++   D  L         TPL  A++ G
Sbjct: 493 QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL------GCSTPLMEASQEG 546

Query: 938 LTMVVQELLGKGASVLAVDENGYTPALACAPN--KDVADCL 976
              +V+ LL  GA+V A    G T       N   DVAD L
Sbjct: 547 HLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587



 Score =  136 bits (343), Expect = 9e-32
 Identities = 109/352 (30%), Positives = 175/352 (49%), Gaps = 17/352 (4%)

Query: 542 LSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDV 601
           + D  N+  I+PL  A+  G+   +++L+    D++ ++++G T L  A   G V+ V V
Sbjct: 264 VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 323

Query: 602 LINQGASILVKDYILK-RTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLS 660
           L+N+GA+I  +D+     TP+  AA+ GH E  R+L+ +    N    +    ++ L L+
Sbjct: 324 LLNEGANI--EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFK--ESALTLA 379

Query: 661 VLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR 720
              GH D V  LL  GA+ + K     TAL    + GH E    LL  GA+  +      
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439

Query: 721 TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQ-- 778
           +P+ L+A  GH+ +   L++  A+++      ++ GYT L  A   GHE  V LLL Q  
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEE----VNDEGYTPLMEAAREGHEEMVALLLAQGA 495

Query: 779 EVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVEC 838
            +  +TE    + L  A        A+ LI   GA I         TPL  A+   H+E 
Sbjct: 496 NINAQTEETQETALTLACCGGFSEVADFLIKA-GADIELGCS----TPLMEASQEGHLEL 550

Query: 839 LQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSK 890
           ++ LL+  A V++  +TG T L  A ENG T+  ++L+  A A+L  Q++ K
Sbjct: 551 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLL-QAGADLDKQEDMK 601



 Score =  132 bits (333), Expect = 1e-30
 Identities = 119/425 (28%), Positives = 194/425 (45%), Gaps = 14/425 (3%)

Query: 102 ARDKNWQTPLHIAAANKAVKCA--EALVPLL----SNVNVSDRAGRTALHHAAFSGHGEM 155
           A  K +  P  +     +V CA  EA   L      N + + +    +L  A   G    
Sbjct: 161 ADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNA 220

Query: 156 VKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS-YTPLHAAA 214
           V+ LL  G ++N   ++    +  A   G+ E+ ++L++  A V  +  K   TPL AA+
Sbjct: 221 VRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAAS 280

Query: 215 SSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFT 274
           S G + +VK LL    D+N  +A GNT L  AC  G   +V  L++ GA +   NE G T
Sbjct: 281 SGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHT 340

Query: 275 PLHFAAASTHGALCLELLVGNGADVNMKSKDGK-TPLHMTALHGRFSRSQTIIQSGAVID 333
           PL  AA++ H  +   +L+ +GA +N  S + K + L +    G     + ++++GA  +
Sbjct: 341 PLMEAASAGHVEVA-RVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399

Query: 334 CEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLS 393
            +    +T L  A   GH  +   L+ SGA           PL LAA  G  +    L+ 
Sbjct: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459

Query: 394 SGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFN-KKDKFGRSPLHYAAANCNYQ 452
            G +++  +D G T L  AA  G+ E + LLL  GA+ N + ++   + L  A      +
Sbjct: 460 RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSE 519

Query: 453 CLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYS 512
               L+ +GA +    E GC+     A+ +   + ++YLL + AN       G  A+ Y+
Sbjct: 520 VADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYA 575

Query: 513 AAYGH 517
              GH
Sbjct: 576 CENGH 580



 Score =  132 bits (331), Expect = 2e-30
 Identities = 117/399 (29%), Positives = 181/399 (45%), Gaps = 27/399 (6%)

Query: 317 GRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHG-MFP 375
           G  +  + ++  G  ++   + G + L +A   G+  L   L+   A+   RG  G + P
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275

Query: 376 LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKD 435
           L  A+  G+ D  + LL    D+++    G T L  A AGG ++ + +LLN GA+    +
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335

Query: 436 KFGRSPLHYAAANCNYQCLFALVGSGASVN----DLDERGCTPLHYAATSDTDGKCLEYL 491
           + G +PL  AA+  + +    L+  GA +N    +  E   T   Y    D     + +L
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM----VRFL 391

Query: 492 LRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATI 551
           L   A+   +  + + A+  +   GH    +L+            SG  +   +D+    
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD----------SGAQVNMPADSFE-- 439

Query: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611
           SPL LAA  GH +   +L++   +L+  N  G TPL  AA +GH E V +L+ QGA+I  
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499

Query: 612 KDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYS 671
           +    + T +  A   G SE    LI     +   DI+ G   TPLM +   GH + V  
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLI-----KAGADIELGCS-TPLMEASQEGHLELVKY 553

Query: 672 LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGA 710
           LL  GANV A    G TAL      GH +  D LLQ GA
Sbjct: 554 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGA 592



 Score =  129 bits (325), Expect = 1e-29
 Identities = 119/403 (29%), Positives = 179/403 (44%), Gaps = 20/403 (4%)

Query: 210 LHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKN 269
           L  A S G ++ V+ LLD G  +NE    G + L +AC  G   +   L+   A V  + 
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268

Query: 270 EKG-FTPLHFAAASTHGAL-CLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQ 327
            KG  TPL   AAS+ G L  ++LL+ + ADVN +S  G T L      G     + ++ 
Sbjct: 269 NKGDITPL--MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326

Query: 328 SGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD-TAKRGIHGMFPLHLAALSGFSD 386
            GA I+  ++NG+TPL  AA  GH  +   L+  GA             L LA   G  D
Sbjct: 327 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386

Query: 387 CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446
             R LL +G D +   D   T L  A   G++E   LLL++GA  N       SPL  AA
Sbjct: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA 446

Query: 447 ANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGY 506
              + +    L+  GA++ ++++ G TPL  AA    + + +  LL   AN   + ++  
Sbjct: 447 CGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHE-EMVALLLAQGANINAQTEETQ 505

Query: 507 NAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQAL 566
                 A  G              D L++      L  S      +PL  A+  GH + +
Sbjct: 506 ETALTLACCG--------GFSEVADFLIKAGADIELGCS------TPLMEASQEGHLELV 551

Query: 567 EVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI 609
           + L+ S  ++    ++G T L  A   GH +  DVL+  GA +
Sbjct: 552 KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594



 Score =  117 bits (292), Expect = 7e-26
 Identities = 111/393 (28%), Positives = 173/393 (44%), Gaps = 45/393 (11%)

Query: 557 AAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYIL 616
           A   G   A+  L+     ++     G + L LA   G+ E   VL+   A++  +    
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271

Query: 617 KRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKG 676
             TP+ AA++ G+ + ++LL+ +    N+   Q   G T L  +   G  D V  LLN+G
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNS---QSATGNTALTYACAGGFVDIVKVLLNEG 328

Query: 677 ANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAAC--GHIGV 734
           AN++  ++ G T L   A  GH E    LL HGA      +  +    L+ AC  GH+ +
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESA-LTLACYKGHLDM 387

Query: 735 LGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAF-SPLH 793
           +  LL++ A  D    T + H  TAL  AC +GH     LLL+         ++F SPL 
Sbjct: 388 VRFLLEAGA--DQEHKTDEMH--TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443

Query: 794 CAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNS-- 851
            A    +   A +LI+  GA++    D +G TPL  AA   H E + LLL+  A +N+  
Sbjct: 444 LAACGGHVELAALLIER-GANLEEVND-EGYTPLMEAAREGHEEMVALLLAQGANINAQT 501

Query: 852 -----------------------------VDSTGKTPLMMAAENGQTNTVEMLVSSASAE 882
                                        ++    TPLM A++ G    V+ L++S  A 
Sbjct: 502 EETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASG-AN 560

Query: 883 LTLQDNSKNTALHLACSKGHETSALLILEKITD 915
           +     + +TAL  AC  GH   A ++L+   D
Sbjct: 561 VHATTATGDTALTYACENGHTDVADVLLQAGAD 593


>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
           [Homo sapiens]
          Length = 616

 Score =  169 bits (429), Expect = 1e-41
 Identities = 125/399 (31%), Positives = 202/399 (50%), Gaps = 7/399 (1%)

Query: 8   DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
           D  SL +A  +GD + VR L+ +   VN    E  + L  A   G  E+ ++L+   A V
Sbjct: 194 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 253

Query: 68  NAKDSKW-LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126
             + +K  +TPL  A +    + V++LL H ADVN++     T L  A A   V   + L
Sbjct: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313

Query: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR-AIHWAAYMGH 185
           +   +N+   +  G T L  AA +GH E+ ++LL  GA IN    + +  A+  A Y GH
Sbjct: 314 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 373

Query: 186 IEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245
           +++V+ L+  GA+   K  + +T L  A   G + V + LLD G  +N P     +PL +
Sbjct: 374 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 433

Query: 246 ACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 305
           A   G   +   LI+ GA + + N++G+TPL  AA   H  + + LL+  GA++N ++++
Sbjct: 434 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM-VALLLAQGANINAQTEE 492

Query: 306 GKTPLHMTALHGRFSR-SQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD 364
            +      A  G FS  +  +I++GA I+      +TPL  A++ GH  L+  L+ SGA+
Sbjct: 493 TQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGAN 549

Query: 365 TAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDD 403
                  G   L  A  +G +D    LL +G D+D  +D
Sbjct: 550 VHATTATGDTALTYACENGHTDVADVLLQAGADLDKQED 588



 Score =  156 bits (394), Expect = 1e-37
 Identities = 122/395 (30%), Positives = 201/395 (50%), Gaps = 17/395 (4%)

Query: 84  SCSE---EAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAG 140
           +CS+    AV+ LL     VN   +  ++ L +A +    + A+ L+ +  + NV DR  
Sbjct: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM--HANVEDRGN 258

Query: 141 R---TALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGA 197
           +   T L  A+  G+ ++VKLLL   A++N+       A+ +A   G +++VK+L++ GA
Sbjct: 259 KGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA 318

Query: 198 EVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN-EPNAYGNTPLHVACYNGQDVVVN 256
            +   ++  +TPL  AAS+G + V + LLD G  +N   N +  + L +ACY G   +V 
Sbjct: 319 NIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVR 378

Query: 257 ELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALH 316
            L++ GA    K ++  T L  A    H  +   LL+ +GA VNM +   ++PL + A  
Sbjct: 379 FLLEAGADQEHKTDEMHTALMEACMDGHVEVA-RLLLDSGAQVNMPADSFESPLTLAACG 437

Query: 317 GRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD-TAKRGIHGMFP 375
           G    +  +I+ GA ++  +  G TPL  AAR GHE ++  L+  GA+  A+        
Sbjct: 438 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA 497

Query: 376 LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKD 435
           L LA   GFS+    L+ +G DI+       T L  A+  G+LE +  LL +GA+ +   
Sbjct: 498 LTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATT 554

Query: 436 KFGRSPLHYAAANCNYQCLFALVGSGASVNDLDER 470
             G + L YA  N +      L+ +GA   DLD++
Sbjct: 555 ATGDTALTYACENGHTDVADVLLQAGA---DLDKQ 586



 Score =  136 bits (343), Expect = 9e-32
 Identities = 109/352 (30%), Positives = 175/352 (49%), Gaps = 17/352 (4%)

Query: 542 LSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDV 601
           + D  N+  I+PL  A+  G+   +++L+    D++ ++++G T L  A   G V+ V V
Sbjct: 253 VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 312

Query: 602 LINQGASILVKDYILK-RTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLS 660
           L+N+GA+I  +D+     TP+  AA+ GH E  R+L+ +    N    +    ++ L L+
Sbjct: 313 LLNEGANI--EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFK--ESALTLA 368

Query: 661 VLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR 720
              GH D V  LL  GA+ + K     TAL    + GH E    LL  GA+  +      
Sbjct: 369 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 428

Query: 721 TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQ-- 778
           +P+ L+A  GH+ +   L++  A+++      ++ GYT L  A   GHE  V LLL Q  
Sbjct: 429 SPLTLAACGGHVELAALLIERGANLEE----VNDEGYTPLMEAAREGHEEMVALLLAQGA 484

Query: 779 EVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVEC 838
            +  +TE    + L  A        A+ LI   GA I         TPL  A+   H+E 
Sbjct: 485 NINAQTEETQETALTLACCGGFSEVADFLIKA-GADIELGCS----TPLMEASQEGHLEL 539

Query: 839 LQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSK 890
           ++ LL+  A V++  +TG T L  A ENG T+  ++L+  A A+L  Q++ K
Sbjct: 540 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLL-QAGADLDKQEDMK 590



 Score =  132 bits (331), Expect = 2e-30
 Identities = 117/399 (29%), Positives = 181/399 (45%), Gaps = 27/399 (6%)

Query: 317 GRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHG-MFP 375
           G  +  + ++  G  ++   + G + L +A   G+  L   L+   A+   RG  G + P
Sbjct: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264

Query: 376 LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKD 435
           L  A+  G+ D  + LL    D+++    G T L  A AGG ++ + +LLN GA+    +
Sbjct: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324

Query: 436 KFGRSPLHYAAANCNYQCLFALVGSGASVN----DLDERGCTPLHYAATSDTDGKCLEYL 491
           + G +PL  AA+  + +    L+  GA +N    +  E   T   Y    D     + +L
Sbjct: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM----VRFL 380

Query: 492 LRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATI 551
           L   A+   +  + + A+  +   GH    +L+            SG  +   +D+    
Sbjct: 381 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD----------SGAQVNMPADSFE-- 428

Query: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611
           SPL LAA  GH +   +L++   +L+  N  G TPL  AA +GH E V +L+ QGA+I  
Sbjct: 429 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 488

Query: 612 KDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYS 671
           +    + T +  A   G SE    LI     +   DI+ G   TPLM +   GH + V  
Sbjct: 489 QTEETQETALTLACCGGFSEVADFLI-----KAGADIELG-CSTPLMEASQEGHLELVKY 542

Query: 672 LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGA 710
           LL  GANV A    G TAL      GH +  D LLQ GA
Sbjct: 543 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGA 581



 Score =  131 bits (330), Expect = 3e-30
 Identities = 109/378 (28%), Positives = 178/378 (47%), Gaps = 8/378 (2%)

Query: 143 ALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK 202
           +L  A   G    V+ LL  G ++N   ++    +  A   G+ E+ ++L++  A V  +
Sbjct: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256

Query: 203 DKKS-YTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDC 261
             K   TPL AA+S G + +VK LL    D+N  +A GNT L  AC  G   +V  L++ 
Sbjct: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316

Query: 262 GAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGK-TPLHMTALHGRFS 320
           GA +   NE G TPL  AA++ H  +   +L+ +GA +N  S + K + L +    G   
Sbjct: 317 GANIEDHNENGHTPLMEAASAGHVEVA-RVLLDHGAGINTHSNEFKESALTLACYKGHLD 375

Query: 321 RSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAA 380
             + ++++GA  + +    +T L  A   GH  +   L+ SGA           PL LAA
Sbjct: 376 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA 435

Query: 381 LSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFN-KKDKFGR 439
             G  +    L+  G +++  +D G T L  AA  G+ E + LLL  GA+ N + ++   
Sbjct: 436 CGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQE 495

Query: 440 SPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPG 499
           + L  A      +    L+ +GA +    E GC+     A+ +   + ++YLL + AN  
Sbjct: 496 TALTLACCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVH 551

Query: 500 IRDKQGYNAVHYSAAYGH 517
                G  A+ Y+   GH
Sbjct: 552 ATTATGDTALTYACENGH 569



 Score =  130 bits (326), Expect = 8e-30
 Identities = 124/421 (29%), Positives = 190/421 (45%), Gaps = 24/421 (5%)

Query: 565 ALEVLVQSLLDLDVRNSSGRTPLDL-----AAFKGHVECVDVLINQGASILVKDYILK-R 618
           AL+    +L  +   NS     +D      A   G V  V  L+++G S  V ++  +  
Sbjct: 171 ALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRS--VNEHTEEGE 228

Query: 619 TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGAN 678
           + +  A + G+ E  ++L+  A   N  D  +    TPLM +   G+ D V  LL   A+
Sbjct: 229 SLLCLACSAGYYELAQVLL--AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDAD 286

Query: 679 VDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGAL 738
           V+++   G TAL      G  + V  LL  GA     +  G TP+  +A+ GH+ V   L
Sbjct: 287 VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVL 346

Query: 739 LQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAF-SPLHCAVI 797
           L   A ++ +   ++    +AL  ACY GH   V  LLE    Q+ + +   + L  A +
Sbjct: 347 LDHGAGINTH---SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 403

Query: 798 NDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGK 857
           + +   A +L+D+ GA +    DS   +PL  AA   HVE   LL+   A +  V+  G 
Sbjct: 404 DGHVEVARLLLDS-GAQVNMPADS-FESPLTLAACGGHVELAALLIERGANLEEVNDEGY 461

Query: 858 TPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRN 917
           TPLM AA  G    V +L++  +      + ++ TAL LAC  G    A  +++   D  
Sbjct: 462 TPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIE 521

Query: 918 LINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPN--KDVADC 975
           L         TPL  A++ G   +V+ LL  GA+V A    G T       N   DVAD 
Sbjct: 522 L------GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADV 575

Query: 976 L 976
           L
Sbjct: 576 L 576



 Score =  129 bits (325), Expect = 1e-29
 Identities = 119/403 (29%), Positives = 179/403 (44%), Gaps = 20/403 (4%)

Query: 210 LHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKN 269
           L  A S G ++ V+ LLD G  +NE    G + L +AC  G   +   L+   A V  + 
Sbjct: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 257

Query: 270 EKG-FTPLHFAAASTHGAL-CLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQ 327
            KG  TPL   AAS+ G L  ++LL+ + ADVN +S  G T L      G     + ++ 
Sbjct: 258 NKGDITPL--MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 315

Query: 328 SGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD-TAKRGIHGMFPLHLAALSGFSD 386
            GA I+  ++NG+TPL  AA  GH  +   L+  GA             L LA   G  D
Sbjct: 316 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 375

Query: 387 CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446
             R LL +G D +   D   T L  A   G++E   LLL++GA  N       SPL  AA
Sbjct: 376 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA 435

Query: 447 ANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGY 506
              + +    L+  GA++ ++++ G TPL  AA    + + +  LL   AN   + ++  
Sbjct: 436 CGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHE-EMVALLLAQGANINAQTEETQ 494

Query: 507 NAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQAL 566
                 A  G              D L++      L  S      +PL  A+  GH + +
Sbjct: 495 ETALTLACCG--------GFSEVADFLIKAGADIELGCS------TPLMEASQEGHLELV 540

Query: 567 EVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI 609
           + L+ S  ++    ++G T L  A   GH +  DVL+  GA +
Sbjct: 541 KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 583



 Score =  117 bits (292), Expect = 7e-26
 Identities = 111/393 (28%), Positives = 173/393 (44%), Gaps = 45/393 (11%)

Query: 557 AAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYIL 616
           A   G   A+  L+     ++     G + L LA   G+ E   VL+   A++  +    
Sbjct: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260

Query: 617 KRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKG 676
             TP+ AA++ G+ + ++LL+ +    N+   Q   G T L  +   G  D V  LLN+G
Sbjct: 261 DITPLMAASSGGYLDIVKLLLLHDADVNS---QSATGNTALTYACAGGFVDIVKVLLNEG 317

Query: 677 ANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAAC--GHIGV 734
           AN++  ++ G T L   A  GH E    LL HGA      +  +    L+ AC  GH+ +
Sbjct: 318 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESA-LTLACYKGHLDM 376

Query: 735 LGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAF-SPLH 793
           +  LL++ A  D    T + H  TAL  AC +GH     LLL+         ++F SPL 
Sbjct: 377 VRFLLEAGA--DQEHKTDEMH--TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 432

Query: 794 CAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNS-- 851
            A    +   A +LI+  GA++    D +G TPL  AA   H E + LLL+  A +N+  
Sbjct: 433 LAACGGHVELAALLIER-GANLEEVND-EGYTPLMEAAREGHEEMVALLLAQGANINAQT 490

Query: 852 -----------------------------VDSTGKTPLMMAAENGQTNTVEMLVSSASAE 882
                                        ++    TPLM A++ G    V+ L++S  A 
Sbjct: 491 EETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASG-AN 549

Query: 883 LTLQDNSKNTALHLACSKGHETSALLILEKITD 915
           +     + +TAL  AC  GH   A ++L+   D
Sbjct: 550 VHATTATGDTALTYACENGHTDVADVLLQAGAD 582


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
           [Homo sapiens]
          Length = 2542

 Score =  168 bits (425), Expect = 3e-41
 Identities = 146/513 (28%), Positives = 231/513 (45%), Gaps = 40/513 (7%)

Query: 8   DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
           D  SL +A  +GD + VR L+ +   VN    E  + L  A   G  E+ ++L+   A V
Sbjct: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264

Query: 68  NAKDSKW-LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126
             + +K  +TPL  A +    + V++LL H ADVN++                       
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSAT-------------------- 304

Query: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHI 186
                        G TAL +A   G  ++VK+LL+ GANI   ++     +  AA  GH+
Sbjct: 305 -------------GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 351

Query: 187 EVVKLLVSHGAEV-TCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245
           EV ++L+ HGA + T  ++   + L  A   G + +V++LL+ G D        +T L  
Sbjct: 352 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411

Query: 246 ACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 305
           AC +G   V   L+D GA VN   +   +PL  AA   H  L   LL+  GA++   + +
Sbjct: 412 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA-ALLIERGANLEEVNDE 470

Query: 306 GKTPLHMTALHGRFSRSQTIIQSGAVIDCE-DKNGNTPLHIAARYGHELLINTLITSGAD 364
           G TPL   A  G       ++  GA I+ + ++   T L +A   G   + + LI +GAD
Sbjct: 471 GYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD 530

Query: 365 TAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLL 424
                +    PL  A+  G  +  + LL+SG ++      G T L  A   G+ +  ++L
Sbjct: 531 IE---LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587

Query: 425 LNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTD 484
           L  GAD   + + GR+PL  AA   +   +  L+  GA+VN         +   A +   
Sbjct: 588 LQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGH 647

Query: 485 GKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGH 517
              +E LL + A+P  R K G   +  +A  GH
Sbjct: 648 LAVVELLLAHGADPTHRLKDGSTMLIEAAKGGH 680



 Score =  166 bits (420), Expect = 1e-40
 Identities = 164/584 (28%), Positives = 251/584 (42%), Gaps = 70/584 (11%)

Query: 317 GRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHG-MFP 375
           G  +  + ++  G  ++   + G + L +A   G+  L   L+   A+   RG  G + P
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275

Query: 376 LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKD 435
           L  A+  G+ D  + LL    D+++    G T L  A AGG ++ + +LLN GA+    +
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335

Query: 436 KFGRSPLHYAAANCNYQCLFALVGSGASVN----DLDERGCTPLHYAATSDTDGKCLEYL 491
           + G +PL  AA+  + +    L+  GA +N    +  E   T   Y    D     + +L
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM----VRFL 391

Query: 492 LRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATI 551
           L   A+   +  + + A+  +   GH    +L+            SG  +   +D+    
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD----------SGAQVNMPADSFE-- 439

Query: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611
           SPL LAA  GH +   +L++   +L+  N  G TPL  AA +GH E V +L+ QGA+I  
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499

Query: 612 KDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYS 671
           +    + T +  A   G SE    LI     +   DI+ G   TPLM +   GH + V  
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLI-----KAGADIELGCS-TPLMEASQEGHLELVKY 553

Query: 672 LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGH 731
           LL  GANV A    G TAL      GH +  D LLQ GA        GRTP+  +A  GH
Sbjct: 554 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH 613

Query: 732 IGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSP 791
           +  +  L+   A++  N ATA N+ +T +  AC  GH   VELLL          +   P
Sbjct: 614 LCTVQFLISKGANV--NRATA-NNDHTVVSLACAGGHLAVVELLL---------AHGADP 661

Query: 792 LHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNS 851
            H                             G T L  AA   H   +  LL +   V S
Sbjct: 662 THRL-------------------------KDGSTMLIEAAKGGHTNVVSYLLDYPNNVLS 696

Query: 852 VDSTGKTPLMMAAENGQ------TNTVEMLVSSASAELTLQDNS 889
           V +T  + L   +++        T+T+ M+V     + T Q+NS
Sbjct: 697 VPTTDVSQLPPPSQDQSQVPRVPTHTLAMVVPPQEPDRTSQENS 740



 Score =  155 bits (391), Expect = 2e-37
 Identities = 158/588 (26%), Positives = 256/588 (43%), Gaps = 64/588 (10%)

Query: 102 ARDKNWQTPLHIAAANKAVKCA--EALVPLL----SNVNVSDRAGRTALHHAAFSGHGEM 155
           A  K +  P  +     +V CA  EA   L      N + + +    +L  A   G    
Sbjct: 161 ADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNA 220

Query: 156 VKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS-YTPLHAAA 214
           V+ LL  G ++N   ++    +  A   G+ E+ ++L++  A V  +  K   TPL AA+
Sbjct: 221 VRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAAS 280

Query: 215 SSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFT 274
           S G + +VK LL    D+N  +A GNT L  AC  G   +V  L++ GA +   NE G T
Sbjct: 281 SGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHT 340

Query: 275 PLHFAAASTHGALCLELLVGNGADVNMKSKDGK-TPLHMTALHGRFSRSQTIIQSGAVID 333
           PL  AA++ H  +   +L+ +GA +N  S + K + L +    G     + ++++GA  +
Sbjct: 341 PLMEAASAGHVEVA-RVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399

Query: 334 CEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLS 393
            +    +T L  A   GH  +   L+ SGA           PL LAA  G  +    L+ 
Sbjct: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459

Query: 394 SGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFN-KKDKFGRSPLHYAAANCNYQ 452
            G +++  +D G T L  AA  G+ E + LLL  GA+ N + ++   + L  A      +
Sbjct: 460 RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSE 519

Query: 453 CLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYS 512
               L+ +GA +    E GC+     A+ +   + ++YLL + AN       G  A+ Y+
Sbjct: 520 VADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYA 575

Query: 513 AAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQS 572
              GH             DVL++ +G D+  +S+                          
Sbjct: 576 CENGH---------TDVADVLLQ-AGADLEHESE-------------------------- 599

Query: 573 LLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSEC 632
                     GRTPL  AA  GH+  V  LI++GA++         T +  A   GH   
Sbjct: 600 ---------GGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAV 650

Query: 633 LRLLIGN-AEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANV 679
           + LL+ + A+P + +     +G T L+ +   GHT+ V  LL+   NV
Sbjct: 651 VELLLAHGADPTHRLK----DGSTMLIEAAKGGHTNVVSYLLDYPNNV 694



 Score =  155 bits (391), Expect = 2e-37
 Identities = 150/502 (29%), Positives = 218/502 (43%), Gaps = 23/502 (4%)

Query: 210 LHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKN 269
           L  A S G ++ V+ LLD G  +NE    G + L +AC  G   +   L+   A V  + 
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268

Query: 270 EKG-FTPLHFAAASTHGAL-CLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQ 327
            KG  TPL   AAS+ G L  ++LL+ + ADVN +S  G T L      G     + ++ 
Sbjct: 269 NKGDITPL--MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326

Query: 328 SGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD-TAKRGIHGMFPLHLAALSGFSD 386
            GA I+  ++NG+TPL  AA  GH  +   L+  GA             L LA   G  D
Sbjct: 327 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386

Query: 387 CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446
             R LL +G D +   D   T L  A   G++E   LLL++GA  N       SPL  AA
Sbjct: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA 446

Query: 447 ANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGY 506
              + +    L+  GA++ ++++ G TPL  AA    + + +  LL   AN   + ++  
Sbjct: 447 CGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHE-EMVALLLAQGANINAQTEETQ 505

Query: 507 NAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQAL 566
                 A  G              D L++      L  S      +PL  A+  GH + +
Sbjct: 506 ETALTLACCG--------GFSEVADFLIKAGADIELGCS------TPLMEASQEGHLELV 551

Query: 567 EVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAAT 626
           + L+ S  ++    ++G T L  A   GH +  DVL+  GA  L  +    RTP+  AA 
Sbjct: 552 KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD-LEHESEGGRTPLMKAAR 610

Query: 627 NGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWG 686
            GH   ++ LI      N       N  T + L+   GH   V  LL  GA+   + K G
Sbjct: 611 AGHLCTVQFLISKGANVNRATA--NNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDG 668

Query: 687 RTALHRGAVTGHEECVDALLQH 708
            T L   A  GH   V  LL +
Sbjct: 669 STMLIEAAKGGHTNVVSYLLDY 690



 Score =  148 bits (373), Expect = 3e-35
 Identities = 103/324 (31%), Positives = 177/324 (54%), Gaps = 8/324 (2%)

Query: 176  AIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN-E 234
            A+  A   GH E+V +L++  A++  +DKK +TPL  AA++G + VV+ LLD G D+  +
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117

Query: 235  PNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVG 294
                 +TPL +AC  G+  VV+ L+  GA    +N   +TPL  AA+  +  + +++L+ 
Sbjct: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI-IKILLN 1176

Query: 295  NGADVNMK--SKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCE-DKNGNTPLHIAARYGH 351
             GA++N +  SK G +PL + A++G     + ++  G+ I+ + + N NT L +A   G 
Sbjct: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1236

Query: 352  ELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTP--DDFGRTCL 409
              +++ L+   A+   R   G+ PL  AA  G+++  R LL  G D++ P       T L
Sbjct: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296

Query: 410  HAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDE 469
              AA  G+ +   LL++ GA  + ++K G +PL  A+   ++  +  LV +GA V+  D 
Sbjct: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADN 1356

Query: 470  RGCTPLHYAATSDTDGKCLEYLLR 493
            R  TPL  +A      K ++YL++
Sbjct: 1357 RKITPL-MSAFRKGHVKVVQYLVK 1379



 Score =  147 bits (370), Expect = 7e-35
 Identities = 112/352 (31%), Positives = 177/352 (50%), Gaps = 9/352 (2%)

Query: 12  LVQAIFNGDPDEVRALIFKKEDVNFQDNE-KRTPLHAAAYLGDAEIIELLILSGARVNAK 70
           L++A   G  +  R L+     +N   NE K + L  A Y G  +++  L+ +GA    K
Sbjct: 342 LMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHK 401

Query: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
             +  T L  A      E  ++LL   A VN    ++++PL +AA    V+ A  L+   
Sbjct: 402 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 461

Query: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINA-FDKKDRRAIHWAAYMGHIEVV 189
           +N+   +  G T L  AA  GH EMV LLL++GANINA  ++    A+  A   G  EV 
Sbjct: 462 ANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVA 521

Query: 190 KLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYN 249
             L+  GA++   +    TPL  A+  G + +VKYLL  G +++   A G+T L  AC N
Sbjct: 522 DFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACEN 578

Query: 250 GQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALC-LELLVGNGADVN-MKSKDGK 307
           G   V + L+  GA +  ++E G TPL  AA + H  LC ++ L+  GA+VN   + +  
Sbjct: 579 GHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH--LCTVQFLISKGANVNRATANNDH 636

Query: 308 TPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLI 359
           T + +    G  +  + ++  GA      K+G+T L  AA+ GH  +++ L+
Sbjct: 637 TVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688



 Score =  146 bits (369), Expect = 9e-35
 Identities = 126/423 (29%), Positives = 192/423 (45%), Gaps = 9/423 (2%)

Query: 8   DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
           D   L+ A   G  D V+ L+    DVN Q     T L  A   G  +I+++L+  GA +
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331

Query: 68  NAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNW-QTPLHIAAANKAVKCAEAL 126
              +    TPL  A ++   E  +VLL H A +N     + ++ L +A     +     L
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391

Query: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHI 186
           +   ++         TAL  A   GH E+ +LLL  GA +N         +  AA  GH+
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451

Query: 187 EVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN-EPNAYGNTPLHV 245
           E+  LL+  GA +   + + YTPL  AA  G   +V  LL  G ++N +      T L +
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511

Query: 246 ACYNGQDVVVNELIDCGAIVNQKNEKG-FTPLHFAAASTHGALCLELLVGNGADVNMKSK 304
           AC  G   V + LI  GA +    E G  TPL  A+   H  L ++ L+ +GA+V+  + 
Sbjct: 512 ACCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLEL-VKYLLASGANVHATTA 566

Query: 305 DGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD 364
            G T L     +G    +  ++Q+GA ++ E + G TPL  AAR GH   +  LI+ GA+
Sbjct: 567 TGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGAN 626

Query: 365 TAKRGIHGMFP-LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNL 423
             +   +     + LA   G       LL+ G D       G T L  AA GG+   ++ 
Sbjct: 627 VNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSY 686

Query: 424 LLN 426
           LL+
Sbjct: 687 LLD 689



 Score =  142 bits (358), Expect = 2e-33
 Identities = 131/447 (29%), Positives = 201/447 (44%), Gaps = 46/447 (10%)

Query: 542 LSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDV 601
           + D  N+  I+PL  A+  G+   +++L+    D++ ++++G T L  A   G V+ V V
Sbjct: 264 VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 323

Query: 602 LINQGASILVKDYILK-RTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLS 660
           L+N+GA+I  +D+     TP+  AA+ GH E  R+L+ +    N    +    ++ L L+
Sbjct: 324 LLNEGANI--EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFK--ESALTLA 379

Query: 661 VLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR 720
              GH D V  LL  GA+ + K     TAL    + GH E    LL  GA+  +      
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439

Query: 721 TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQ-- 778
           +P+ L+A  GH+ +   L++  A+++      ++ GYT L  A   GHE  V LLL Q  
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEE----VNDEGYTPLMEAAREGHEEMVALLLAQGA 495

Query: 779 EVFQKTEGNAFSPLHCAVINDNEGAAEMLIDT-----LGASI------------------ 815
            +  +TE    + L  A        A+ LI       LG S                   
Sbjct: 496 NINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLL 555

Query: 816 -----VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTN 870
                V+AT + G T L  A    H +   +LL   A +      G+TPLM AA  G   
Sbjct: 556 ASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLC 615

Query: 871 TVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITD--RNLINATNAALQT 928
           TV+ L+S  +       N+ +T + LAC+ GH     L+L    D    L + +     T
Sbjct: 616 TVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGS-----T 670

Query: 929 PLHVAARNGLTMVVQELLGKGASVLAV 955
            L  AA+ G T VV  LL    +VL+V
Sbjct: 671 MLIEAAKGGHTNVVSYLLDYPNNVLSV 697



 Score =  140 bits (352), Expect = 8e-33
 Identities = 109/348 (31%), Positives = 165/348 (47%), Gaps = 42/348 (12%)

Query: 43   TPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNA 102
            T L  A   G  E++ +LI   A++  +D K  TPL  A  +     V++LL    D+ A
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 103  RDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSR 162
            +                                S+R   T L  A   G  E+V LLL+R
Sbjct: 1117 Q--------------------------------SERTKDTPLSLACSGGRQEVVDLLLAR 1144

Query: 163  GANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK--DKKSYTPLHAAASSGMIS 220
            GAN    +  D   +  AA  G++ ++K+L++ GAE+  +   K   +PL  AA +G + 
Sbjct: 1145 GANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVP 1204

Query: 221  VVKYLLDLGVDMN-EPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFA 279
             VK LLD+G D+N +     NT L +AC+ G+  VV+ L+D  A V  + + G TPL  A
Sbjct: 1205 AVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEA 1264

Query: 280  AASTHGALCLELLVGNGADVNM----KSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCE 335
            A+  +  +   +L+  GADVN      S+D  T L + A  G +   + +I  GA ID  
Sbjct: 1265 ASGGYAEVG-RVLLDKGADVNAPPVPSSRD--TALTIAADKGHYKFCELLIHRGAHIDVR 1321

Query: 336  DKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSG 383
            +K GNTPL +A+  GH  ++  L+ +GAD        + PL  A   G
Sbjct: 1322 NKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369



 Score =  137 bits (344), Expect = 7e-32
 Identities = 137/510 (26%), Positives = 228/510 (44%), Gaps = 25/510 (4%)

Query: 246 ACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 305
           AC +G    V +L+D G  VN+  E+G + L  A ++ +  L   LL  +    +  +K 
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271

Query: 306 GKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADT 365
             TPL   +  G     + ++   A ++ +   GNT L  A   G   ++  L+  GA+ 
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331

Query: 366 AKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDT-PDDFGRTCLHAAAAGGNLECLNLL 424
                +G  PL  AA +G  +  R LL  G  I+T  ++F  + L  A   G+L+ +  L
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391

Query: 425 LNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTD 484
           L  GAD   K     + L  A  + + +    L+ SGA VN   +   +PL  AA     
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGG-H 450

Query: 485 GKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSD 544
            +    L+   AN    + +GY  +  +A  GH   + L+ ++          G ++ + 
Sbjct: 451 VELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ----------GANINAQ 500

Query: 545 SDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLIN 604
           ++     + L LA   G  +  + L+++  D+++  S   TPL  A+ +GH+E V  L+ 
Sbjct: 501 TEETQETA-LTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLA 556

Query: 605 QGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGN--GQTPLMLSVL 662
            GA++         T +  A  NGH++   +L+     Q   D++  +  G+TPLM +  
Sbjct: 557 SGANVHATT-ATGDTALTYACENGHTDVADVLL-----QAGADLEHESEGGRTPLMKAAR 610

Query: 663 NGHTDCVYSLLNKGANVD-AKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRT 721
            GH   V  L++KGANV+ A      T +      GH   V+ LL HGA    R   G T
Sbjct: 611 AGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGST 670

Query: 722 PIHLSAACGHIGVLGALLQSAASMDANPAT 751
            +  +A  GH  V+  LL    ++ + P T
Sbjct: 671 MLIEAAKGGHTNVVSYLLDYPNNVLSVPTT 700



 Score =  134 bits (337), Expect = 5e-31
 Identities = 133/477 (27%), Positives = 205/477 (42%), Gaps = 44/477 (9%)

Query: 526 SETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQ-ALEVLVQSLLDLDVRNSSGR 584
           ++  L+ L+E +G   LS +D +A   P  L         AL+    +L  +   NS   
Sbjct: 142 TQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNA 201

Query: 585 TPLDL-----AAFKGHVECVDVLINQGASILVKDYILK-RTPIHAAATNGHSECLRLLIG 638
             +D      A   G V  V  L+++G S  V ++  +  + +  A + G+ E  ++L+ 
Sbjct: 202 GQVDTRSLAEACSDGDVNAVRKLLDEGRS--VNEHTEEGESLLCLACSAGYYELAQVLL- 258

Query: 639 NAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGH 698
            A   N  D  +    TPLM +   G+ D V  LL   A+V+++   G TAL      G 
Sbjct: 259 -AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGF 317

Query: 699 EECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYT 758
            + V  LL  GA     +  G TP+  +A+ GH+ V   LL   A ++ +   ++    +
Sbjct: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTH---SNEFKES 374

Query: 759 ALHWACYNGHETCVELLLEQEVFQKTEGNAF-SPLHCAVINDNEGAAEMLIDTLGASIVN 817
           AL  ACY GH   V  LLE    Q+ + +   + L  A ++ +   A +L+D+ GA +  
Sbjct: 375 ALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS-GAQVNM 433

Query: 818 ATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVS 877
             DS   +PL  AA   HVE   LL+   A +  V+  G TPLM AA  G    V +L++
Sbjct: 434 PADSF-ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA 492

Query: 878 SASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNL------------------- 918
             +      + ++ TAL LAC  G    A  +++   D  L                   
Sbjct: 493 QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVK 552

Query: 919 --------INATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACA 967
                   ++AT A   T L  A  NG T V   LL  GA +    E G TP +  A
Sbjct: 553 YLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 609



 Score =  132 bits (331), Expect = 2e-30
 Identities = 105/323 (32%), Positives = 158/323 (48%), Gaps = 7/323 (2%)

Query: 11   SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
            +L  A   G  + V  LI +   +  +D +  TPL  AA  G   ++E+L+  G  + A+
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117

Query: 71   DSKWL-TPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPL 129
              +   TPL  A +   +E V +LL   A+   R+ +  TPL +AA+   V   + L+  
Sbjct: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177

Query: 130  LSNVN--VSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR-AIHWAAYMGHI 186
             + +N     + G + L  AA +GH   VKLLL  G++INA  + +R  A+  A + G  
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237

Query: 187  EVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEP--NAYGNTPLH 244
            EVV LL+   A V  + K   TPL  AAS G   V + LLD G D+N P   +  +T L 
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297

Query: 245  VACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSK 304
            +A   G       LI  GA ++ +N+KG TPL  A+   H  + ++LLV  GADV+    
Sbjct: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDV-VQLLVQAGADVDAADN 1356

Query: 305  DGKTPLHMTALHGRFSRSQTIIQ 327
               TPL      G     Q +++
Sbjct: 1357 RKITPLMSAFRKGHVKVVQYLVK 1379



 Score =  127 bits (318), Expect = 7e-29
 Identities = 97/329 (29%), Positives = 161/329 (48%), Gaps = 10/329 (3%)

Query: 123  AEALVPLLSNVNV---SDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHW 179
            ++++ P+  +V++   ++    TAL  A   GH E+V +L++R A I   DKK    +  
Sbjct: 1035 SQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLIL 1094

Query: 180  AAYMGHIEVVKLLVSHGAEVTCKDKKSY-TPLHAAASSGMISVVKYLLDLGVDMNEPNAY 238
            AA  GH+ VV++L+  G ++  + +++  TPL  A S G   VV  LL  G +    N  
Sbjct: 1095 AATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVS 1154

Query: 239  GNTPLHVACYNGQDVVVNELIDCGAIVNQK--NEKGFTPLHFAAASTHGALCLELLVGNG 296
              TPL +A   G   ++  L++ GA +N +  ++ G +PL  AA + H    ++LL+  G
Sbjct: 1155 DYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH-VPAVKLLLDMG 1213

Query: 297  ADVNMKSKDGK-TPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLI 355
            +D+N + +  + T L +    GR      ++   A ++   K G TPL  AA  G+  + 
Sbjct: 1214 SDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVG 1273

Query: 356  NTLITSGADTAKRGIHGM--FPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAA 413
              L+  GAD     +       L +AA  G    C  L+  G  ID  +  G T L  A+
Sbjct: 1274 RVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLAS 1333

Query: 414  AGGNLECLNLLLNTGADFNKKDKFGRSPL 442
             GG+ + + LL+  GAD +  D    +PL
Sbjct: 1334 NGGHFDVVQLLVQAGADVDAADNRKITPL 1362



 Score =  119 bits (297), Expect = 2e-26
 Identities = 110/371 (29%), Positives = 172/371 (46%), Gaps = 51/371 (13%)

Query: 240  NTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADV 299
            +T L +AC  G + +V+ LI   A +  +++KGFTPL  AA + H  + +E+L+  G D+
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGV-VEILLDKGGDI 1114

Query: 300  NMKSKDGK-TPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTL 358
              +S+  K TPL +    GR      ++  GA  +  + +  TPL +AA  G+  +I  L
Sbjct: 1115 EAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL 1174

Query: 359  ITSGADTAKR--GIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGR-TCLHAAAAG 415
            + +GA+   R     G+ PL LAA++G     + LL  G DI+   +  R T L  A   
Sbjct: 1175 LNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQ 1234

Query: 416  GNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPL 475
            G  E ++LLL+  A+   + K G +PL  AA+    +    L+  GA VN        P+
Sbjct: 1235 GRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN------APPV 1288

Query: 476  HYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGH-RLCLQLIASETPLDVLM 534
                                  P  RD     A+  +A  GH + C  LI     +DV  
Sbjct: 1289 ----------------------PSSRD----TALTIAADKGHYKFCELLIHRGAHIDV-- 1320

Query: 535  ETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKG 594
                        N+   +PL LA+  GH   +++LVQ+  D+D  ++   TPL  A  KG
Sbjct: 1321 -----------RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369

Query: 595  HVECVDVLINQ 605
            HV+ V  L+ +
Sbjct: 1370 HVKVVQYLVKE 1380



 Score =  119 bits (297), Expect = 2e-26
 Identities = 107/394 (27%), Positives = 172/394 (43%), Gaps = 59/394 (14%)

Query: 554  LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 613
            L LA   GH + + VL+     ++ R+  G TPL LAA  GHV  V++L+++G  I  + 
Sbjct: 1059 LTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQS 1118

Query: 614  YILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLL 673
               K TP+  A + G  E + LL+     +   ++ D    TPL L+   G+ + +  LL
Sbjct: 1119 ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSD---YTPLSLAASGGYVNIIKILL 1175

Query: 674  NKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIG 733
            N GA ++++             TG +  +  L+                  L+A  GH+ 
Sbjct: 1176 NAGAEINSR-------------TGSKLGISPLM------------------LAAMNGHVP 1204

Query: 734  VLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV-FQKTEGNAFSPL 792
             +  LL   + ++A   T  N   TAL  AC+ G    V LLL+++   +       +PL
Sbjct: 1205 AVKLLLDMGSDINAQIETNRN---TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPL 1261

Query: 793  HCAVINDNEGAAEMLIDTLGASIVNA--TDSKGRTPLHAAAFTDHVECLQLLLSHNAQVN 850
              A          +L+D  GA  VNA    S   T L  AA   H +  +LL+   A ++
Sbjct: 1262 MEAASGGYAEVGRVLLDK-GAD-VNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHID 1319

Query: 851  SVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGH-------- 902
              +  G TPL +A+  G  + V++LV  A A++   DN K T L  A  KGH        
Sbjct: 1320 VRNKKGNTPLWLASNGGHFDVVQLLV-QAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378

Query: 903  --------ETSALLILEKITDRNLINATNAALQT 928
                    +   +  +  ITD+ L+   +  ++T
Sbjct: 1379 KEVNQFPSDIECMRYIATITDKELLKKCHQCVET 1412



 Score =  117 bits (293), Expect = 6e-26
 Identities = 101/329 (30%), Positives = 150/329 (45%), Gaps = 16/329 (4%)

Query: 645  AVDIQ---DGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEEC 701
            +VDI    + N  T L L+   GH + V  L+ + A ++ +DK G T L   A  GH   
Sbjct: 1044 SVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGV 1103

Query: 702  VDALLQHGAKCLLRDSRGR-TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTAL 760
            V+ LL  G     +  R + TP+ L+ + G   V+  LL    +  AN    +   YT L
Sbjct: 1104 VEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLL----ARGANKEHRNVSDYTPL 1159

Query: 761  HWACYNGHETCVELLLE--QEVFQKTEGN-AFSPLHCAVINDNEGAAEMLIDTLGASIVN 817
              A   G+   +++LL    E+  +T      SPL  A +N +  A ++L+D +G+ I  
Sbjct: 1160 SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD-MGSDINA 1218

Query: 818  ATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLV- 876
              ++   T L  A F    E + LLL   A V     TG TPLM AA  G      +L+ 
Sbjct: 1219 QIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLD 1278

Query: 877  SSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARN 936
              A        +S++TAL +A  KGH     L++ +      I+  N    TPL +A+  
Sbjct: 1279 KGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAH---IDVRNKKGNTPLWLASNG 1335

Query: 937  GLTMVVQELLGKGASVLAVDENGYTPALA 965
            G   VVQ L+  GA V A D    TP ++
Sbjct: 1336 GHFDVVQLLVQAGADVDAADNRKITPLMS 1364



 Score =  103 bits (256), Expect = 1e-21
 Identities = 80/260 (30%), Positives = 130/260 (50%), Gaps = 6/260 (2%)

Query: 5    KLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSG 64
            + +D P L  A   G  + V  L+ +  +   ++    TPL  AA  G   II++L+ +G
Sbjct: 1120 RTKDTP-LSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 1178

Query: 65   ARVNAKDSKWL--TPLHRAVASCSEEAVQVLLKHSADVNAR-DKNWQTPLHIAAANKAVK 121
            A +N++    L  +PL  A  +    AV++LL   +D+NA+ + N  T L +A      +
Sbjct: 1179 AEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAE 1238

Query: 122  CAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR--AIHW 179
                L+   +NV    + G T L  AA  G+ E+ ++LL +GA++NA      R  A+  
Sbjct: 1239 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1298

Query: 180  AAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYG 239
            AA  GH +  +LL+  GA +  ++KK  TPL  A++ G   VV+ L+  G D++  +   
Sbjct: 1299 AADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRK 1358

Query: 240  NTPLHVACYNGQDVVVNELI 259
             TPL  A   G   VV  L+
Sbjct: 1359 ITPLMSAFRKGHVKVVQYLV 1378



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 88/321 (27%), Positives = 147/321 (45%), Gaps = 45/321 (14%)

Query: 663 NGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR-T 721
           +G  + V  LL++G +V+   + G + L      G+ E    LL   A    R ++G  T
Sbjct: 215 DGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 274

Query: 722 PIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVF 781
           P+  +++ G++ ++  LL   A +++  AT    G TAL +AC  G    V++LL     
Sbjct: 275 PLMAASSGGYLDIVKLLLLHDADVNSQSAT----GNTALTYACAGGFVDIVKVLL----- 325

Query: 782 QKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQL 841
                             NEGA            +   +  G TPL  AA   HVE  ++
Sbjct: 326 ------------------NEGAN-----------IEDHNENGHTPLMEAASAGHVEVARV 356

Query: 842 LLSHNAQVNSVDSTGK-TPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSK 900
           LL H A +N+  +  K + L +A   G  + V  L+  A A+   + +  +TAL  AC  
Sbjct: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE-AGADQEHKTDEMHTALMEACMD 415

Query: 901 GHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGY 960
           GH   A L+L+       +N    + ++PL +AA  G   +   L+ +GA++  V++ GY
Sbjct: 416 GHVEVARLLLDSGAQ---VNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGY 472

Query: 961 TPALACAPNKDVADCLALILA 981
           TP +  A  +   + +AL+LA
Sbjct: 473 TPLMEAA-REGHEEMVALLLA 492



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 54/193 (27%), Positives = 87/193 (45%), Gaps = 7/193 (3%)

Query: 782  QKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQL 841
            Q TE    +P  C+    N  +  M        I   T+S   T L  A    H E + +
Sbjct: 1016 QTTE--CLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSV 1073

Query: 842  LLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKG 901
            L++ +A++   D  G TPL++AA  G    VE+L+          + +K+T L LACS G
Sbjct: 1074 LIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGG 1133

Query: 902  HETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASV--LAVDENG 959
             +    L+L +  ++   N ++    TPL +AA  G   +++ LL  GA +      + G
Sbjct: 1134 RQEVVDLLLARGANKEHRNVSD---YTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 1190

Query: 960  YTPALACAPNKDV 972
             +P +  A N  V
Sbjct: 1191 ISPLMLAAMNGHV 1203



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 43/166 (25%), Positives = 73/166 (43%), Gaps = 1/166 (0%)

Query: 2   AFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLI 61
           A ++L     L++A   G  + V+ L+    +V+       T L  A   G  ++ ++L+
Sbjct: 529 ADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLL 588

Query: 62  LSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVN-ARDKNWQTPLHIAAANKAV 120
            +GA +  +     TPL +A  +     VQ L+   A+VN A   N  T + +A A   +
Sbjct: 589 QAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHL 648

Query: 121 KCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANI 166
              E L+   ++     + G T L  AA  GH  +V  LL    N+
Sbjct: 649 AVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNV 694



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 30/107 (28%), Positives = 55/107 (51%), Gaps = 9/107 (8%)

Query: 27   LIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCS 86
            LI +   ++ ++ +  TPL  A+  G  ++++LL+ +GA V+A D++ +TPL  A     
Sbjct: 1311 LIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGH 1370

Query: 87   EEAVQVLLKHSADVNARDKNWQTPLHIAA------ANKAVKCAEALV 127
             + VQ L+K   +VN    + +   +IA         K  +C E +V
Sbjct: 1371 VKVVQYLVK---EVNQFPSDIECMRYIATITDKELLKKCHQCVETIV 1414



 Score = 38.9 bits (89), Expect = 0.026
 Identities = 37/124 (29%), Positives = 57/124 (45%), Gaps = 5/124 (4%)

Query: 887  DNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELL 946
            +++ +TAL LAC+ GHE    +++ +  D  + +       TPL +AA  G   VV+ LL
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIAR--DAKIEHRDKKGF-TPLILAATAGHVGVVEILL 1108

Query: 947  GKGASVLAVDENGY-TP-ALACAPNKDVADCLALILATMMPVSSSSPLSSLTFNAINRYT 1004
             KG  + A  E    TP +LAC+  +     L L         + S  + L+  A   Y 
Sbjct: 1109 DKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYV 1168

Query: 1005 NTSK 1008
            N  K
Sbjct: 1169 NIIK 1172


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score =  168 bits (425), Expect = 3e-41
 Identities = 146/513 (28%), Positives = 231/513 (45%), Gaps = 40/513 (7%)

Query: 8   DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
           D  SL +A  +GD + VR L+ +   VN    E  + L  A   G  E+ ++L+   A V
Sbjct: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264

Query: 68  NAKDSKW-LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126
             + +K  +TPL  A +    + V++LL H ADVN++                       
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSAT-------------------- 304

Query: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHI 186
                        G TAL +A   G  ++VK+LL+ GANI   ++     +  AA  GH+
Sbjct: 305 -------------GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 351

Query: 187 EVVKLLVSHGAEV-TCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245
           EV ++L+ HGA + T  ++   + L  A   G + +V++LL+ G D        +T L  
Sbjct: 352 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411

Query: 246 ACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 305
           AC +G   V   L+D GA VN   +   +PL  AA   H  L   LL+  GA++   + +
Sbjct: 412 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA-ALLIERGANLEEVNDE 470

Query: 306 GKTPLHMTALHGRFSRSQTIIQSGAVIDCE-DKNGNTPLHIAARYGHELLINTLITSGAD 364
           G TPL   A  G       ++  GA I+ + ++   T L +A   G   + + LI +GAD
Sbjct: 471 GYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD 530

Query: 365 TAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLL 424
                +    PL  A+  G  +  + LL+SG ++      G T L  A   G+ +  ++L
Sbjct: 531 IE---LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587

Query: 425 LNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTD 484
           L  GAD   + + GR+PL  AA   +   +  L+  GA+VN         +   A +   
Sbjct: 588 LQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGH 647

Query: 485 GKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGH 517
              +E LL + A+P  R K G   +  +A  GH
Sbjct: 648 LAVVELLLAHGADPTHRLKDGSTMLIEAAKGGH 680



 Score =  166 bits (420), Expect = 1e-40
 Identities = 164/584 (28%), Positives = 251/584 (42%), Gaps = 70/584 (11%)

Query: 317 GRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHG-MFP 375
           G  +  + ++  G  ++   + G + L +A   G+  L   L+   A+   RG  G + P
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275

Query: 376 LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKD 435
           L  A+  G+ D  + LL    D+++    G T L  A AGG ++ + +LLN GA+    +
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335

Query: 436 KFGRSPLHYAAANCNYQCLFALVGSGASVN----DLDERGCTPLHYAATSDTDGKCLEYL 491
           + G +PL  AA+  + +    L+  GA +N    +  E   T   Y    D     + +L
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM----VRFL 391

Query: 492 LRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATI 551
           L   A+   +  + + A+  +   GH    +L+            SG  +   +D+    
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD----------SGAQVNMPADSFE-- 439

Query: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611
           SPL LAA  GH +   +L++   +L+  N  G TPL  AA +GH E V +L+ QGA+I  
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499

Query: 612 KDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYS 671
           +    + T +  A   G SE    LI     +   DI+ G   TPLM +   GH + V  
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLI-----KAGADIELGCS-TPLMEASQEGHLELVKY 553

Query: 672 LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGH 731
           LL  GANV A    G TAL      GH +  D LLQ GA        GRTP+  +A  GH
Sbjct: 554 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH 613

Query: 732 IGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSP 791
           +  +  L+   A++  N ATA N+ +T +  AC  GH   VELLL          +   P
Sbjct: 614 LCTVQFLISKGANV--NRATA-NNDHTVVSLACAGGHLAVVELLL---------AHGADP 661

Query: 792 LHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNS 851
            H                             G T L  AA   H   +  LL +   V S
Sbjct: 662 THRL-------------------------KDGSTMLIEAAKGGHTNVVSYLLDYPNNVLS 696

Query: 852 VDSTGKTPLMMAAENGQ------TNTVEMLVSSASAELTLQDNS 889
           V +T  + L   +++        T+T+ M+V     + T Q+NS
Sbjct: 697 VPTTDVSQLPPPSQDQSQVPRVPTHTLAMVVPPQEPDRTSQENS 740



 Score =  155 bits (391), Expect = 2e-37
 Identities = 158/588 (26%), Positives = 256/588 (43%), Gaps = 64/588 (10%)

Query: 102 ARDKNWQTPLHIAAANKAVKCA--EALVPLL----SNVNVSDRAGRTALHHAAFSGHGEM 155
           A  K +  P  +     +V CA  EA   L      N + + +    +L  A   G    
Sbjct: 161 ADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNA 220

Query: 156 VKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS-YTPLHAAA 214
           V+ LL  G ++N   ++    +  A   G+ E+ ++L++  A V  +  K   TPL AA+
Sbjct: 221 VRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAAS 280

Query: 215 SSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFT 274
           S G + +VK LL    D+N  +A GNT L  AC  G   +V  L++ GA +   NE G T
Sbjct: 281 SGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHT 340

Query: 275 PLHFAAASTHGALCLELLVGNGADVNMKSKDGK-TPLHMTALHGRFSRSQTIIQSGAVID 333
           PL  AA++ H  +   +L+ +GA +N  S + K + L +    G     + ++++GA  +
Sbjct: 341 PLMEAASAGHVEVA-RVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399

Query: 334 CEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLS 393
            +    +T L  A   GH  +   L+ SGA           PL LAA  G  +    L+ 
Sbjct: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459

Query: 394 SGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFN-KKDKFGRSPLHYAAANCNYQ 452
            G +++  +D G T L  AA  G+ E + LLL  GA+ N + ++   + L  A      +
Sbjct: 460 RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSE 519

Query: 453 CLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYS 512
               L+ +GA +    E GC+     A+ +   + ++YLL + AN       G  A+ Y+
Sbjct: 520 VADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYA 575

Query: 513 AAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQS 572
              GH             DVL++ +G D+  +S+                          
Sbjct: 576 CENGH---------TDVADVLLQ-AGADLEHESE-------------------------- 599

Query: 573 LLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSEC 632
                     GRTPL  AA  GH+  V  LI++GA++         T +  A   GH   
Sbjct: 600 ---------GGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAV 650

Query: 633 LRLLIGN-AEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANV 679
           + LL+ + A+P + +     +G T L+ +   GHT+ V  LL+   NV
Sbjct: 651 VELLLAHGADPTHRLK----DGSTMLIEAAKGGHTNVVSYLLDYPNNV 694



 Score =  155 bits (391), Expect = 2e-37
 Identities = 150/502 (29%), Positives = 218/502 (43%), Gaps = 23/502 (4%)

Query: 210 LHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKN 269
           L  A S G ++ V+ LLD G  +NE    G + L +AC  G   +   L+   A V  + 
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268

Query: 270 EKG-FTPLHFAAASTHGAL-CLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQ 327
            KG  TPL   AAS+ G L  ++LL+ + ADVN +S  G T L      G     + ++ 
Sbjct: 269 NKGDITPL--MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326

Query: 328 SGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD-TAKRGIHGMFPLHLAALSGFSD 386
            GA I+  ++NG+TPL  AA  GH  +   L+  GA             L LA   G  D
Sbjct: 327 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386

Query: 387 CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446
             R LL +G D +   D   T L  A   G++E   LLL++GA  N       SPL  AA
Sbjct: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA 446

Query: 447 ANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGY 506
              + +    L+  GA++ ++++ G TPL  AA    + + +  LL   AN   + ++  
Sbjct: 447 CGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHE-EMVALLLAQGANINAQTEETQ 505

Query: 507 NAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQAL 566
                 A  G              D L++      L  S      +PL  A+  GH + +
Sbjct: 506 ETALTLACCG--------GFSEVADFLIKAGADIELGCS------TPLMEASQEGHLELV 551

Query: 567 EVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAAT 626
           + L+ S  ++    ++G T L  A   GH +  DVL+  GA  L  +    RTP+  AA 
Sbjct: 552 KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD-LEHESEGGRTPLMKAAR 610

Query: 627 NGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWG 686
            GH   ++ LI      N       N  T + L+   GH   V  LL  GA+   + K G
Sbjct: 611 AGHLCTVQFLISKGANVNRATA--NNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDG 668

Query: 687 RTALHRGAVTGHEECVDALLQH 708
            T L   A  GH   V  LL +
Sbjct: 669 STMLIEAAKGGHTNVVSYLLDY 690



 Score =  148 bits (373), Expect = 3e-35
 Identities = 103/324 (31%), Positives = 177/324 (54%), Gaps = 8/324 (2%)

Query: 176  AIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN-E 234
            A+  A   GH E+V +L++  A++  +DKK +TPL  AA++G + VV+ LLD G D+  +
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117

Query: 235  PNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVG 294
                 +TPL +AC  G+  VV+ L+  GA    +N   +TPL  AA+  +  + +++L+ 
Sbjct: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI-IKILLN 1176

Query: 295  NGADVNMK--SKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCE-DKNGNTPLHIAARYGH 351
             GA++N +  SK G +PL + A++G     + ++  G+ I+ + + N NT L +A   G 
Sbjct: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1236

Query: 352  ELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTP--DDFGRTCL 409
              +++ L+   A+   R   G+ PL  AA  G+++  R LL  G D++ P       T L
Sbjct: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296

Query: 410  HAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDE 469
              AA  G+ +   LL++ GA  + ++K G +PL  A+   ++  +  LV +GA V+  D 
Sbjct: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADN 1356

Query: 470  RGCTPLHYAATSDTDGKCLEYLLR 493
            R  TPL  +A      K ++YL++
Sbjct: 1357 RKITPL-MSAFRKGHVKVVQYLVK 1379



 Score =  147 bits (370), Expect = 7e-35
 Identities = 112/352 (31%), Positives = 177/352 (50%), Gaps = 9/352 (2%)

Query: 12  LVQAIFNGDPDEVRALIFKKEDVNFQDNE-KRTPLHAAAYLGDAEIIELLILSGARVNAK 70
           L++A   G  +  R L+     +N   NE K + L  A Y G  +++  L+ +GA    K
Sbjct: 342 LMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHK 401

Query: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
             +  T L  A      E  ++LL   A VN    ++++PL +AA    V+ A  L+   
Sbjct: 402 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 461

Query: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINA-FDKKDRRAIHWAAYMGHIEVV 189
           +N+   +  G T L  AA  GH EMV LLL++GANINA  ++    A+  A   G  EV 
Sbjct: 462 ANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVA 521

Query: 190 KLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYN 249
             L+  GA++   +    TPL  A+  G + +VKYLL  G +++   A G+T L  AC N
Sbjct: 522 DFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACEN 578

Query: 250 GQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALC-LELLVGNGADVN-MKSKDGK 307
           G   V + L+  GA +  ++E G TPL  AA + H  LC ++ L+  GA+VN   + +  
Sbjct: 579 GHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH--LCTVQFLISKGANVNRATANNDH 636

Query: 308 TPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLI 359
           T + +    G  +  + ++  GA      K+G+T L  AA+ GH  +++ L+
Sbjct: 637 TVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688



 Score =  146 bits (369), Expect = 9e-35
 Identities = 126/423 (29%), Positives = 192/423 (45%), Gaps = 9/423 (2%)

Query: 8   DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
           D   L+ A   G  D V+ L+    DVN Q     T L  A   G  +I+++L+  GA +
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331

Query: 68  NAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNW-QTPLHIAAANKAVKCAEAL 126
              +    TPL  A ++   E  +VLL H A +N     + ++ L +A     +     L
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391

Query: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHI 186
           +   ++         TAL  A   GH E+ +LLL  GA +N         +  AA  GH+
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451

Query: 187 EVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN-EPNAYGNTPLHV 245
           E+  LL+  GA +   + + YTPL  AA  G   +V  LL  G ++N +      T L +
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511

Query: 246 ACYNGQDVVVNELIDCGAIVNQKNEKG-FTPLHFAAASTHGALCLELLVGNGADVNMKSK 304
           AC  G   V + LI  GA +    E G  TPL  A+   H  L ++ L+ +GA+V+  + 
Sbjct: 512 ACCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLEL-VKYLLASGANVHATTA 566

Query: 305 DGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD 364
            G T L     +G    +  ++Q+GA ++ E + G TPL  AAR GH   +  LI+ GA+
Sbjct: 567 TGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGAN 626

Query: 365 TAKRGIHGMFP-LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNL 423
             +   +     + LA   G       LL+ G D       G T L  AA GG+   ++ 
Sbjct: 627 VNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSY 686

Query: 424 LLN 426
           LL+
Sbjct: 687 LLD 689



 Score =  142 bits (358), Expect = 2e-33
 Identities = 131/447 (29%), Positives = 201/447 (44%), Gaps = 46/447 (10%)

Query: 542 LSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDV 601
           + D  N+  I+PL  A+  G+   +++L+    D++ ++++G T L  A   G V+ V V
Sbjct: 264 VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 323

Query: 602 LINQGASILVKDYILK-RTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLS 660
           L+N+GA+I  +D+     TP+  AA+ GH E  R+L+ +    N    +    ++ L L+
Sbjct: 324 LLNEGANI--EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFK--ESALTLA 379

Query: 661 VLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR 720
              GH D V  LL  GA+ + K     TAL    + GH E    LL  GA+  +      
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439

Query: 721 TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQ-- 778
           +P+ L+A  GH+ +   L++  A+++      ++ GYT L  A   GHE  V LLL Q  
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEE----VNDEGYTPLMEAAREGHEEMVALLLAQGA 495

Query: 779 EVFQKTEGNAFSPLHCAVINDNEGAAEMLIDT-----LGASI------------------ 815
            +  +TE    + L  A        A+ LI       LG S                   
Sbjct: 496 NINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLL 555

Query: 816 -----VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTN 870
                V+AT + G T L  A    H +   +LL   A +      G+TPLM AA  G   
Sbjct: 556 ASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLC 615

Query: 871 TVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITD--RNLINATNAALQT 928
           TV+ L+S  +       N+ +T + LAC+ GH     L+L    D    L + +     T
Sbjct: 616 TVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGS-----T 670

Query: 929 PLHVAARNGLTMVVQELLGKGASVLAV 955
            L  AA+ G T VV  LL    +VL+V
Sbjct: 671 MLIEAAKGGHTNVVSYLLDYPNNVLSV 697



 Score =  140 bits (352), Expect = 8e-33
 Identities = 109/348 (31%), Positives = 165/348 (47%), Gaps = 42/348 (12%)

Query: 43   TPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNA 102
            T L  A   G  E++ +LI   A++  +D K  TPL  A  +     V++LL    D+ A
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 103  RDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSR 162
            +                                S+R   T L  A   G  E+V LLL+R
Sbjct: 1117 Q--------------------------------SERTKDTPLSLACSGGRQEVVDLLLAR 1144

Query: 163  GANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK--DKKSYTPLHAAASSGMIS 220
            GAN    +  D   +  AA  G++ ++K+L++ GAE+  +   K   +PL  AA +G + 
Sbjct: 1145 GANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVP 1204

Query: 221  VVKYLLDLGVDMN-EPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFA 279
             VK LLD+G D+N +     NT L +AC+ G+  VV+ L+D  A V  + + G TPL  A
Sbjct: 1205 AVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEA 1264

Query: 280  AASTHGALCLELLVGNGADVNM----KSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCE 335
            A+  +  +   +L+  GADVN      S+D  T L + A  G +   + +I  GA ID  
Sbjct: 1265 ASGGYAEVG-RVLLDKGADVNAPPVPSSRD--TALTIAADKGHYKFCELLIHRGAHIDVR 1321

Query: 336  DKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSG 383
            +K GNTPL +A+  GH  ++  L+ +GAD        + PL  A   G
Sbjct: 1322 NKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369



 Score =  137 bits (344), Expect = 7e-32
 Identities = 137/510 (26%), Positives = 228/510 (44%), Gaps = 25/510 (4%)

Query: 246 ACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 305
           AC +G    V +L+D G  VN+  E+G + L  A ++ +  L   LL  +    +  +K 
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271

Query: 306 GKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADT 365
             TPL   +  G     + ++   A ++ +   GNT L  A   G   ++  L+  GA+ 
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331

Query: 366 AKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDT-PDDFGRTCLHAAAAGGNLECLNLL 424
                +G  PL  AA +G  +  R LL  G  I+T  ++F  + L  A   G+L+ +  L
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391

Query: 425 LNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTD 484
           L  GAD   K     + L  A  + + +    L+ SGA VN   +   +PL  AA     
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGG-H 450

Query: 485 GKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSD 544
            +    L+   AN    + +GY  +  +A  GH   + L+ ++          G ++ + 
Sbjct: 451 VELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ----------GANINAQ 500

Query: 545 SDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLIN 604
           ++     + L LA   G  +  + L+++  D+++  S   TPL  A+ +GH+E V  L+ 
Sbjct: 501 TEETQETA-LTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLA 556

Query: 605 QGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGN--GQTPLMLSVL 662
            GA++         T +  A  NGH++   +L+     Q   D++  +  G+TPLM +  
Sbjct: 557 SGANVHATT-ATGDTALTYACENGHTDVADVLL-----QAGADLEHESEGGRTPLMKAAR 610

Query: 663 NGHTDCVYSLLNKGANVD-AKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRT 721
            GH   V  L++KGANV+ A      T +      GH   V+ LL HGA    R   G T
Sbjct: 611 AGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGST 670

Query: 722 PIHLSAACGHIGVLGALLQSAASMDANPAT 751
            +  +A  GH  V+  LL    ++ + P T
Sbjct: 671 MLIEAAKGGHTNVVSYLLDYPNNVLSVPTT 700



 Score =  134 bits (337), Expect = 5e-31
 Identities = 133/477 (27%), Positives = 205/477 (42%), Gaps = 44/477 (9%)

Query: 526 SETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQ-ALEVLVQSLLDLDVRNSSGR 584
           ++  L+ L+E +G   LS +D +A   P  L         AL+    +L  +   NS   
Sbjct: 142 TQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNA 201

Query: 585 TPLDL-----AAFKGHVECVDVLINQGASILVKDYILK-RTPIHAAATNGHSECLRLLIG 638
             +D      A   G V  V  L+++G S  V ++  +  + +  A + G+ E  ++L+ 
Sbjct: 202 GQVDTRSLAEACSDGDVNAVRKLLDEGRS--VNEHTEEGESLLCLACSAGYYELAQVLL- 258

Query: 639 NAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGH 698
            A   N  D  +    TPLM +   G+ D V  LL   A+V+++   G TAL      G 
Sbjct: 259 -AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGF 317

Query: 699 EECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYT 758
            + V  LL  GA     +  G TP+  +A+ GH+ V   LL   A ++ +   ++    +
Sbjct: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTH---SNEFKES 374

Query: 759 ALHWACYNGHETCVELLLEQEVFQKTEGNAF-SPLHCAVINDNEGAAEMLIDTLGASIVN 817
           AL  ACY GH   V  LLE    Q+ + +   + L  A ++ +   A +L+D+ GA +  
Sbjct: 375 ALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS-GAQVNM 433

Query: 818 ATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVS 877
             DS   +PL  AA   HVE   LL+   A +  V+  G TPLM AA  G    V +L++
Sbjct: 434 PADSF-ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA 492

Query: 878 SASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNL------------------- 918
             +      + ++ TAL LAC  G    A  +++   D  L                   
Sbjct: 493 QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVK 552

Query: 919 --------INATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACA 967
                   ++AT A   T L  A  NG T V   LL  GA +    E G TP +  A
Sbjct: 553 YLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 609



 Score =  132 bits (331), Expect = 2e-30
 Identities = 105/323 (32%), Positives = 158/323 (48%), Gaps = 7/323 (2%)

Query: 11   SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
            +L  A   G  + V  LI +   +  +D +  TPL  AA  G   ++E+L+  G  + A+
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117

Query: 71   DSKWL-TPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPL 129
              +   TPL  A +   +E V +LL   A+   R+ +  TPL +AA+   V   + L+  
Sbjct: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177

Query: 130  LSNVN--VSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR-AIHWAAYMGHI 186
             + +N     + G + L  AA +GH   VKLLL  G++INA  + +R  A+  A + G  
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237

Query: 187  EVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEP--NAYGNTPLH 244
            EVV LL+   A V  + K   TPL  AAS G   V + LLD G D+N P   +  +T L 
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297

Query: 245  VACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSK 304
            +A   G       LI  GA ++ +N+KG TPL  A+   H  + ++LLV  GADV+    
Sbjct: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDV-VQLLVQAGADVDAADN 1356

Query: 305  DGKTPLHMTALHGRFSRSQTIIQ 327
               TPL      G     Q +++
Sbjct: 1357 RKITPLMSAFRKGHVKVVQYLVK 1379



 Score =  127 bits (318), Expect = 7e-29
 Identities = 97/329 (29%), Positives = 161/329 (48%), Gaps = 10/329 (3%)

Query: 123  AEALVPLLSNVNV---SDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHW 179
            ++++ P+  +V++   ++    TAL  A   GH E+V +L++R A I   DKK    +  
Sbjct: 1035 SQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLIL 1094

Query: 180  AAYMGHIEVVKLLVSHGAEVTCKDKKSY-TPLHAAASSGMISVVKYLLDLGVDMNEPNAY 238
            AA  GH+ VV++L+  G ++  + +++  TPL  A S G   VV  LL  G +    N  
Sbjct: 1095 AATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVS 1154

Query: 239  GNTPLHVACYNGQDVVVNELIDCGAIVNQK--NEKGFTPLHFAAASTHGALCLELLVGNG 296
              TPL +A   G   ++  L++ GA +N +  ++ G +PL  AA + H    ++LL+  G
Sbjct: 1155 DYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH-VPAVKLLLDMG 1213

Query: 297  ADVNMKSKDGK-TPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLI 355
            +D+N + +  + T L +    GR      ++   A ++   K G TPL  AA  G+  + 
Sbjct: 1214 SDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVG 1273

Query: 356  NTLITSGADTAKRGIHGM--FPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAA 413
              L+  GAD     +       L +AA  G    C  L+  G  ID  +  G T L  A+
Sbjct: 1274 RVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLAS 1333

Query: 414  AGGNLECLNLLLNTGADFNKKDKFGRSPL 442
             GG+ + + LL+  GAD +  D    +PL
Sbjct: 1334 NGGHFDVVQLLVQAGADVDAADNRKITPL 1362



 Score =  119 bits (297), Expect = 2e-26
 Identities = 110/371 (29%), Positives = 172/371 (46%), Gaps = 51/371 (13%)

Query: 240  NTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADV 299
            +T L +AC  G + +V+ LI   A +  +++KGFTPL  AA + H  + +E+L+  G D+
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGV-VEILLDKGGDI 1114

Query: 300  NMKSKDGK-TPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTL 358
              +S+  K TPL +    GR      ++  GA  +  + +  TPL +AA  G+  +I  L
Sbjct: 1115 EAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL 1174

Query: 359  ITSGADTAKR--GIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGR-TCLHAAAAG 415
            + +GA+   R     G+ PL LAA++G     + LL  G DI+   +  R T L  A   
Sbjct: 1175 LNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQ 1234

Query: 416  GNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPL 475
            G  E ++LLL+  A+   + K G +PL  AA+    +    L+  GA VN        P+
Sbjct: 1235 GRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN------APPV 1288

Query: 476  HYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGH-RLCLQLIASETPLDVLM 534
                                  P  RD     A+  +A  GH + C  LI     +DV  
Sbjct: 1289 ----------------------PSSRD----TALTIAADKGHYKFCELLIHRGAHIDV-- 1320

Query: 535  ETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKG 594
                        N+   +PL LA+  GH   +++LVQ+  D+D  ++   TPL  A  KG
Sbjct: 1321 -----------RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369

Query: 595  HVECVDVLINQ 605
            HV+ V  L+ +
Sbjct: 1370 HVKVVQYLVKE 1380



 Score =  119 bits (297), Expect = 2e-26
 Identities = 107/394 (27%), Positives = 172/394 (43%), Gaps = 59/394 (14%)

Query: 554  LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 613
            L LA   GH + + VL+     ++ R+  G TPL LAA  GHV  V++L+++G  I  + 
Sbjct: 1059 LTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQS 1118

Query: 614  YILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLL 673
               K TP+  A + G  E + LL+     +   ++ D    TPL L+   G+ + +  LL
Sbjct: 1119 ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSD---YTPLSLAASGGYVNIIKILL 1175

Query: 674  NKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIG 733
            N GA ++++             TG +  +  L+                  L+A  GH+ 
Sbjct: 1176 NAGAEINSR-------------TGSKLGISPLM------------------LAAMNGHVP 1204

Query: 734  VLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV-FQKTEGNAFSPL 792
             +  LL   + ++A   T  N   TAL  AC+ G    V LLL+++   +       +PL
Sbjct: 1205 AVKLLLDMGSDINAQIETNRN---TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPL 1261

Query: 793  HCAVINDNEGAAEMLIDTLGASIVNA--TDSKGRTPLHAAAFTDHVECLQLLLSHNAQVN 850
              A          +L+D  GA  VNA    S   T L  AA   H +  +LL+   A ++
Sbjct: 1262 MEAASGGYAEVGRVLLDK-GAD-VNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHID 1319

Query: 851  SVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGH-------- 902
              +  G TPL +A+  G  + V++LV  A A++   DN K T L  A  KGH        
Sbjct: 1320 VRNKKGNTPLWLASNGGHFDVVQLLV-QAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378

Query: 903  --------ETSALLILEKITDRNLINATNAALQT 928
                    +   +  +  ITD+ L+   +  ++T
Sbjct: 1379 KEVNQFPSDIECMRYIATITDKELLKKCHQCVET 1412



 Score =  117 bits (293), Expect = 6e-26
 Identities = 101/329 (30%), Positives = 150/329 (45%), Gaps = 16/329 (4%)

Query: 645  AVDIQ---DGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEEC 701
            +VDI    + N  T L L+   GH + V  L+ + A ++ +DK G T L   A  GH   
Sbjct: 1044 SVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGV 1103

Query: 702  VDALLQHGAKCLLRDSRGR-TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTAL 760
            V+ LL  G     +  R + TP+ L+ + G   V+  LL    +  AN    +   YT L
Sbjct: 1104 VEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLL----ARGANKEHRNVSDYTPL 1159

Query: 761  HWACYNGHETCVELLLE--QEVFQKTEGN-AFSPLHCAVINDNEGAAEMLIDTLGASIVN 817
              A   G+   +++LL    E+  +T      SPL  A +N +  A ++L+D +G+ I  
Sbjct: 1160 SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD-MGSDINA 1218

Query: 818  ATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLV- 876
              ++   T L  A F    E + LLL   A V     TG TPLM AA  G      +L+ 
Sbjct: 1219 QIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLD 1278

Query: 877  SSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARN 936
              A        +S++TAL +A  KGH     L++ +      I+  N    TPL +A+  
Sbjct: 1279 KGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAH---IDVRNKKGNTPLWLASNG 1335

Query: 937  GLTMVVQELLGKGASVLAVDENGYTPALA 965
            G   VVQ L+  GA V A D    TP ++
Sbjct: 1336 GHFDVVQLLVQAGADVDAADNRKITPLMS 1364



 Score =  103 bits (256), Expect = 1e-21
 Identities = 80/260 (30%), Positives = 130/260 (50%), Gaps = 6/260 (2%)

Query: 5    KLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSG 64
            + +D P L  A   G  + V  L+ +  +   ++    TPL  AA  G   II++L+ +G
Sbjct: 1120 RTKDTP-LSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 1178

Query: 65   ARVNAKDSKWL--TPLHRAVASCSEEAVQVLLKHSADVNAR-DKNWQTPLHIAAANKAVK 121
            A +N++    L  +PL  A  +    AV++LL   +D+NA+ + N  T L +A      +
Sbjct: 1179 AEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAE 1238

Query: 122  CAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR--AIHW 179
                L+   +NV    + G T L  AA  G+ E+ ++LL +GA++NA      R  A+  
Sbjct: 1239 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1298

Query: 180  AAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYG 239
            AA  GH +  +LL+  GA +  ++KK  TPL  A++ G   VV+ L+  G D++  +   
Sbjct: 1299 AADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRK 1358

Query: 240  NTPLHVACYNGQDVVVNELI 259
             TPL  A   G   VV  L+
Sbjct: 1359 ITPLMSAFRKGHVKVVQYLV 1378



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 88/321 (27%), Positives = 147/321 (45%), Gaps = 45/321 (14%)

Query: 663 NGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR-T 721
           +G  + V  LL++G +V+   + G + L      G+ E    LL   A    R ++G  T
Sbjct: 215 DGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 274

Query: 722 PIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVF 781
           P+  +++ G++ ++  LL   A +++  AT    G TAL +AC  G    V++LL     
Sbjct: 275 PLMAASSGGYLDIVKLLLLHDADVNSQSAT----GNTALTYACAGGFVDIVKVLL----- 325

Query: 782 QKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQL 841
                             NEGA            +   +  G TPL  AA   HVE  ++
Sbjct: 326 ------------------NEGAN-----------IEDHNENGHTPLMEAASAGHVEVARV 356

Query: 842 LLSHNAQVNSVDSTGK-TPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSK 900
           LL H A +N+  +  K + L +A   G  + V  L+  A A+   + +  +TAL  AC  
Sbjct: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE-AGADQEHKTDEMHTALMEACMD 415

Query: 901 GHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGY 960
           GH   A L+L+       +N    + ++PL +AA  G   +   L+ +GA++  V++ GY
Sbjct: 416 GHVEVARLLLDSGAQ---VNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGY 472

Query: 961 TPALACAPNKDVADCLALILA 981
           TP +  A  +   + +AL+LA
Sbjct: 473 TPLMEAA-REGHEEMVALLLA 492



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 54/193 (27%), Positives = 87/193 (45%), Gaps = 7/193 (3%)

Query: 782  QKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQL 841
            Q TE    +P  C+    N  +  M        I   T+S   T L  A    H E + +
Sbjct: 1016 QTTE--CLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSV 1073

Query: 842  LLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKG 901
            L++ +A++   D  G TPL++AA  G    VE+L+          + +K+T L LACS G
Sbjct: 1074 LIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGG 1133

Query: 902  HETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASV--LAVDENG 959
             +    L+L +  ++   N ++    TPL +AA  G   +++ LL  GA +      + G
Sbjct: 1134 RQEVVDLLLARGANKEHRNVSD---YTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 1190

Query: 960  YTPALACAPNKDV 972
             +P +  A N  V
Sbjct: 1191 ISPLMLAAMNGHV 1203



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 43/166 (25%), Positives = 73/166 (43%), Gaps = 1/166 (0%)

Query: 2   AFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLI 61
           A ++L     L++A   G  + V+ L+    +V+       T L  A   G  ++ ++L+
Sbjct: 529 ADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLL 588

Query: 62  LSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVN-ARDKNWQTPLHIAAANKAV 120
            +GA +  +     TPL +A  +     VQ L+   A+VN A   N  T + +A A   +
Sbjct: 589 QAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHL 648

Query: 121 KCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANI 166
              E L+   ++     + G T L  AA  GH  +V  LL    N+
Sbjct: 649 AVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNV 694



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 30/107 (28%), Positives = 55/107 (51%), Gaps = 9/107 (8%)

Query: 27   LIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCS 86
            LI +   ++ ++ +  TPL  A+  G  ++++LL+ +GA V+A D++ +TPL  A     
Sbjct: 1311 LIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGH 1370

Query: 87   EEAVQVLLKHSADVNARDKNWQTPLHIAA------ANKAVKCAEALV 127
             + VQ L+K   +VN    + +   +IA         K  +C E +V
Sbjct: 1371 VKVVQYLVK---EVNQFPSDIECMRYIATITDKELLKKCHQCVETIV 1414



 Score = 38.9 bits (89), Expect = 0.026
 Identities = 37/124 (29%), Positives = 57/124 (45%), Gaps = 5/124 (4%)

Query: 887  DNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELL 946
            +++ +TAL LAC+ GHE    +++ +  D  + +       TPL +AA  G   VV+ LL
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIAR--DAKIEHRDKKGF-TPLILAATAGHVGVVEILL 1108

Query: 947  GKGASVLAVDENGY-TP-ALACAPNKDVADCLALILATMMPVSSSSPLSSLTFNAINRYT 1004
             KG  + A  E    TP +LAC+  +     L L         + S  + L+  A   Y 
Sbjct: 1109 DKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYV 1168

Query: 1005 NTSK 1008
            N  K
Sbjct: 1169 NIIK 1172


>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
           sapiens]
          Length = 1771

 Score =  165 bits (417), Expect = 2e-40
 Identities = 118/357 (33%), Positives = 172/357 (48%), Gaps = 1/357 (0%)

Query: 89  AVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAA 148
           A++ LL+   DV+ R++  QTPL IAA    ++  + L+   +N N+ D    TAL  A+
Sbjct: 20  ALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISAS 79

Query: 149 FSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYT 208
             GH  +V+ LL  G N+   D     A+ WA Y G  +VV+LL+SHGA  +     S  
Sbjct: 80  KEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVY 139

Query: 209 PLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQK 268
           P+  AA  G   +V  LL  G  +N  + YG TPL  A   G    V  L+  GA V+Q+
Sbjct: 140 PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQE 199

Query: 269 NEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQS 328
                T L  A    +     E+L  N  +VN+  KDG T L + +  G     Q ++ +
Sbjct: 200 GANSMTALIVAVKGGYTQSVKEILKRN-PNVNLTDKDGNTALMIASKEGHTEIVQDLLDA 258

Query: 329 GAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCC 388
           G  ++  D++G+T L  A R GH  ++  L+   AD   RG      L+ A   G +   
Sbjct: 259 GTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMV 318

Query: 389 RKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYA 445
           R +L    D +     G T L  A    N+E + LLL+ GA  +  DK G +PLH A
Sbjct: 319 RDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375



 Score =  149 bits (375), Expect = 2e-35
 Identities = 134/501 (26%), Positives = 229/501 (45%), Gaps = 13/501 (2%)

Query: 120 VKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHW 179
           +   +AL+    +V+  +  G+T L  AA  G+ E+VK L+  GAN N  D  +  A+  
Sbjct: 18  IPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALIS 77

Query: 180 AAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYG 239
           A+  GH+ +V+ L+  G  +  +D   +T L  A   G   VV+ LL  G + +    Y 
Sbjct: 78  ASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYS 137

Query: 240 NTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADV 299
             P+  A   G   +V+ L+  GA VN  ++ G TPL +AA   H   C++ L+  GADV
Sbjct: 138 VYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGH-LECVKHLLAMGADV 196

Query: 300 NMKSKDGKTPLHMTALHGRFSRS-QTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTL 358
           + +  +  T L + A+ G +++S + I++    ++  DK+GNT L IA++ GH  ++  L
Sbjct: 197 DQEGANSMTAL-IVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255

Query: 359 ITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNL 418
           + +G         G   L  A   G  +  R LL    DID      +T L+ A   GN 
Sbjct: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315

Query: 419 ECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYA 478
             +  +L    D     K G +PL  A    N + +  L+  GA V+ +D++G TPLH A
Sbjct: 316 TMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375

Query: 479 ATSDTDGKCLEYLLRNDANPGI---RDKQGYNAVHYSAAYGHRLCLQLIA------SETP 529
                  K  E LLRN  +  +    +K G    +   ++   +  Q+        +ET 
Sbjct: 376 IRG-RSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETD 434

Query: 530 LDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDL 589
            D+L     +  L+D  +  T+ P      +    + +  +   L+ +++  +G+    L
Sbjct: 435 GDMLGYDLYSSALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPL 494

Query: 590 AAFKGHVECVDVLINQGASIL 610
             F   +  + +L+  G  +L
Sbjct: 495 FQFSWLIVFLTLLLCGGLGLL 515



 Score =  147 bits (372), Expect = 4e-35
 Identities = 110/356 (30%), Positives = 170/356 (47%), Gaps = 1/356 (0%)

Query: 24  VRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVA 83
           ++AL+ K +DV+ ++   +TPL  AA  G+ EI++ LI +GA  N +D    T L  A  
Sbjct: 21  LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80

Query: 84  SCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTA 143
                 V+ LLK   ++  RD    T L  A         E L+   +N +V+       
Sbjct: 81  EGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYP 140

Query: 144 LHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKD 203
           +  AA  GH ++V LLL  GA +N  DK     + WAA  GH+E VK L++ GA+V  + 
Sbjct: 141 IIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEG 200

Query: 204 KKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGA 263
             S T L  A   G    VK +L    ++N  +  GNT L +A   G   +V +L+D G 
Sbjct: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260

Query: 264 IVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQ 323
            VN  +  G T L  A    H  + +  L+   AD++++ +D KT L+     G  +  +
Sbjct: 261 YVNIPDRSGDTVLIGAVRGGHVEI-VRALLQKYADIDIRGQDNKTALYWAVEKGNATMVR 319

Query: 324 TIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLA 379
            I+Q     +   K+G TPL  A +  +  ++  L+  GA  +     G  PLH+A
Sbjct: 320 DILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375



 Score =  135 bits (339), Expect = 3e-31
 Identities = 113/347 (32%), Positives = 161/347 (46%), Gaps = 16/347 (4%)

Query: 618 RTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGA 677
           +TP+  AA  G+ E ++ LI N    N   ++D +  T L+ +   GH   V  LL  G 
Sbjct: 39  QTPLMIAAEQGNLEIVKELIKNGANCN---LEDLDNWTALISASKEGHVHIVEELLKCGV 95

Query: 678 NVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGA 737
           N++ +D  G TAL      G  + V+ LL HGA   +       PI  +A  GH  ++  
Sbjct: 96  NLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHL 155

Query: 738 LLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEG-NAFSPLHCAV 796
           LLQ+ A ++ +    D +G T L WA   GH  CV+ LL        EG N+ + L  AV
Sbjct: 156 LLQNGAKVNCS----DKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAV 211

Query: 797 INDNEGAAEMLIDTLGASI-VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDST 855
                G  + + + L  +  VN TD  G T L  A+   H E +Q LL     VN  D +
Sbjct: 212 ---KGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRS 268

Query: 856 GKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITD 915
           G T L+ A   G    V  L+    A++ ++     TAL+ A  KG+ T    IL+   D
Sbjct: 269 GDTVLIGAVRGGHVEIVRALLQKY-ADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPD 327

Query: 916 RNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 962
             +        +TPL  A +     VV+ LL KGA V AVD+ G TP
Sbjct: 328 TEICTKDG---ETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTP 371



 Score =  130 bits (326), Expect = 8e-30
 Identities = 102/356 (28%), Positives = 161/356 (45%), Gaps = 1/356 (0%)

Query: 9   QPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVN 68
           Q  L+ A   G+ + V+ LI    + N +D +  T L +A+  G   I+E L+  G  + 
Sbjct: 39  QTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLE 98

Query: 69  AKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVP 128
            +D    T L  A      + V++LL H A+ +        P+  AA          L+ 
Sbjct: 99  HRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQ 158

Query: 129 LLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEV 188
             + VN SD+ G T L  AA  GH E VK LL+ GA+++        A+  A   G+ + 
Sbjct: 159 NGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQS 218

Query: 189 VKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACY 248
           VK ++     V   DK   T L  A+  G   +V+ LLD G  +N P+  G+T L  A  
Sbjct: 219 VKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVR 278

Query: 249 NGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKT 308
            G   +V  L+   A ++ + +   T L++A    +  +  ++L  N  D  + +KDG+T
Sbjct: 279 GGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCN-PDTEICTKDGET 337

Query: 309 PLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD 364
           PL            + ++  GA +   DK G+TPLHIA R     L   L+ +  D
Sbjct: 338 PLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKD 393



 Score =  126 bits (317), Expect = 9e-29
 Identities = 124/460 (26%), Positives = 195/460 (42%), Gaps = 59/460 (12%)

Query: 450 NYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAV 509
           N   L AL+     V++ +E G TPL  AA    + + ++ L++N AN  + D   + A+
Sbjct: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQG-NLEIVKELIKNGANCNLEDLDNWTAL 75

Query: 510 HYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVL 569
             ++  GH            + ++ E     +  +  +    + L  A Y G    +E+L
Sbjct: 76  ISASKEGH------------VHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELL 123

Query: 570 VQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGH 629
           +    +  V       P+  AA +GH + V +L+  GA +   D     TP+  AA  GH
Sbjct: 124 LSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKY-GTTPLVWAARKGH 182

Query: 630 SECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTA 689
            EC++ L+        VD +  N  T L+++V  G+T  V  +L +  NV+  DK G TA
Sbjct: 183 LECVKHLLAMGAD---VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTA 239

Query: 690 LHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANP 749
           L   +  GH E V  LL  G    + D  G T +  +   GH+ ++ ALLQ  A +D   
Sbjct: 240 LMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRG 299

Query: 750 ATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLID 809
              DN   TAL+WA   G+ T V  +L+                               D
Sbjct: 300 Q--DNK--TALYWAVEKGNATMVRDILQCNP----------------------------D 327

Query: 810 TLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQT 869
           T            G TPL  A    ++E ++LLL   A+V++VD  G TPL +A      
Sbjct: 328 T------EICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSR 381

Query: 870 NTVEMLVSSASAELTLQDNSK--NTALHLACSKGHETSAL 907
              E+L+ +      L   +K   T  ++ CS  H+ S L
Sbjct: 382 KLAELLLRNPKDGRLLYRPNKAGETPYNIDCS--HQKSIL 419



 Score =  125 bits (315), Expect = 2e-28
 Identities = 98/348 (28%), Positives = 159/348 (45%), Gaps = 6/348 (1%)

Query: 11  SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
           +L+ A   G    V  L+    ++  +D    T L  A Y G  +++ELL+  GA  +  
Sbjct: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133

Query: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
               + P+  A      + V +LL++ A VN  DK   TPL  AA    ++C + L+ + 
Sbjct: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193

Query: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 190
           ++V+       TAL  A   G+ + VK +L R  N+N  DK    A+  A+  GH E+V+
Sbjct: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253

Query: 191 LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 250
            L+  G  V   D+   T L  A   G + +V+ LL    D++       T L+ A   G
Sbjct: 254 DLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKG 313

Query: 251 QDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPL 310
              +V +++ C        + G TPL   A        +ELL+  GA V+   K G TPL
Sbjct: 314 NATMVRDILQCNPDTEICTKDGETPL-IKATKMRNIEVVELLLDKGAKVSAVDKKGDTPL 372

Query: 311 HMTALHGRFSRSQTII----QSGAVIDCEDKNGNTPLHIAARYGHELL 354
           H+ A+ GR  +   ++    + G ++   +K G TP +I   +   +L
Sbjct: 373 HI-AIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSIL 419



 Score =  119 bits (299), Expect = 1e-26
 Identities = 115/415 (27%), Positives = 177/415 (42%), Gaps = 49/415 (11%)

Query: 565 ALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAA 624
           AL+ L++   D+D RN  G+TPL +AA +G++E V  LI  GA+  ++D +   T + +A
Sbjct: 20  ALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLED-LDNWTALISA 78

Query: 625 ATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDK 684
           +  GH   +  L+        ++ +D  G T LM +   G TD V  LL+ GAN      
Sbjct: 79  SKEGHVHIVEELLKCGVN---LEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135

Query: 685 WGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAAS 744
           +    +   A  GH + V  LLQ+GAK    D  G TP+  +A  GH+  +  LL   A 
Sbjct: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195

Query: 745 MDANPATADNHGYTALHWACYNGHETCVELLLEQEV---FQKTEGNAFSPLHCAVINDNE 801
           +D   A +     TAL  A   G+   V+ +L++         +GN        +I   E
Sbjct: 196 VDQEGANS----MTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNT-----ALMIASKE 246

Query: 802 GAAEMLIDTLGA-SIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPL 860
           G  E++ D L A + VN  D  G T L  A    HVE ++ LL   A ++      KT L
Sbjct: 247 GHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTAL 306

Query: 861 MMAAENGQTNTVE--------------------------------MLVSSASAELTLQDN 888
             A E G    V                                  L+    A+++  D 
Sbjct: 307 YWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDK 366

Query: 889 SKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQ 943
             +T LH+A        A L+L    D  L+   N A +TP ++   +  +++ Q
Sbjct: 367 KGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQ 421



 Score =  119 bits (297), Expect = 2e-26
 Identities = 104/408 (25%), Positives = 187/408 (45%), Gaps = 17/408 (4%)

Query: 185 HIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLH 244
           +I  +K L+    +V  +++   TPL  AA  G + +VK L+  G + N  +    T L 
Sbjct: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76

Query: 245 VACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSK 304
            A   G   +V EL+ CG  +  ++  G+T L +A       + +ELL+ +GA+ ++   
Sbjct: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDV-VELLLSHGANPSVTGL 135

Query: 305 DGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD 364
               P+   A  G       ++Q+GA ++C DK G TPL  AAR GH   +  L+  GAD
Sbjct: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195

Query: 365 TAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLL 424
             + G + M  L +A   G++   +++L    +++  D  G T L  A+  G+ E +  L
Sbjct: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255

Query: 425 LNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTD 484
           L+ G   N  D+ G + L  A    + + + AL+   A ++   +   T L++A     +
Sbjct: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKG-N 314

Query: 485 GKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSD 544
              +  +L+ + +  I  K G   +  +    +   ++L+     LD   + S  D   D
Sbjct: 315 ATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELL-----LDKGAKVSAVDKKGD 369

Query: 545 SDNRATISPLHLAAYHGHHQALEVLVQSLLD---LDVRNSSGRTPLDL 589
                  +PLH+A      +  E+L+++  D   L   N +G TP ++
Sbjct: 370 -------TPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNI 410



 Score =  114 bits (286), Expect = 4e-25
 Identities = 86/283 (30%), Positives = 140/283 (49%), Gaps = 11/283 (3%)

Query: 671 SLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACG 730
           +LL K  +VD +++ G+T L   A  G+ E V  L+++GA C L D    T +  ++  G
Sbjct: 23  ALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEG 82

Query: 731 HIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEG-NAF 789
           H+ ++  LL+   +++      D  G+TAL WACY G    VELLL         G  + 
Sbjct: 83  HVHIVEELLKCGVNLEHR----DMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSV 138

Query: 790 SPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQV 849
            P+  A    +     +L+   GA  VN +D  G TPL  AA   H+EC++ LL+  A V
Sbjct: 139 YPIIWAAGRGHADIVHLLLQN-GAK-VNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196

Query: 850 NSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLI 909
           +   +   T L++A + G T +V+ ++   +  + L D   NTAL +A  +GH     ++
Sbjct: 197 DQEGANSMTALIVAVKGGYTQSVKEIL-KRNPNVNLTDKDGNTALMIASKEGHTE---IV 252

Query: 910 LEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASV 952
            + +     +N  + +  T L  A R G   +V+ LL K A +
Sbjct: 253 QDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADI 295



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 33/114 (28%), Positives = 61/114 (53%), Gaps = 3/114 (2%)

Query: 8   DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
           ++ +L  A+  G+   VR ++    D      +  TPL  A  + + E++ELL+  GA+V
Sbjct: 302 NKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKV 361

Query: 68  NAKDSKWLTPLHRAVASCSEEAVQVLLKHSAD---VNARDKNWQTPLHIAAANK 118
           +A D K  TPLH A+   S +  ++LL++  D   +   +K  +TP +I  +++
Sbjct: 362 SAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQ 415



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 56/211 (26%), Positives = 84/211 (39%), Gaps = 38/211 (18%)

Query: 834  DHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVS---------------- 877
            +++  L+ LL     V+  +  G+TPLM+AAE G    V+ L+                 
Sbjct: 16   ENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75

Query: 878  -SASAE---------------LTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINA 921
             SAS E               L  +D    TAL  AC KG      L+L    + ++   
Sbjct: 76   ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSV--- 132

Query: 922  TNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILA 981
            T      P+  AA  G   +V  LL  GA V   D+ G TP L  A  K   +C+  +LA
Sbjct: 133  TGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTP-LVWAARKGHLECVKHLLA 191

Query: 982  TMMPV--SSSSPLSSLTFNAINRYTNTSKTV 1010
                V    ++ +++L       YT + K +
Sbjct: 192  MGADVDQEGANSMTALIVAVKGGYTQSVKEI 222


>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
           sapiens]
          Length = 522

 Score =  164 bits (416), Expect = 3e-40
 Identities = 120/399 (30%), Positives = 190/399 (47%), Gaps = 37/399 (9%)

Query: 45  LHAAAYLGDAEIIELLILSGARVN--AKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNA 102
           LH AA   +   ++ LI  G RVN  A++      LH A  +  E+AV++LL+H A V+ 
Sbjct: 19  LHEAARQNNVGRMQELI--GRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDE 76

Query: 103 RDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSR 162
            D        + A  +A  C                 G  AL  +A+ GH  ++++L++ 
Sbjct: 77  EDA-------VGALTEARLCF----------------GMNALLLSAWFGHLRILQILVNS 113

Query: 163 GANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK--DKKSYTPLHAAASSGMIS 220
           GA I+   K     +H AA  GH+ V+  ++    +V     DK   T  H AA  G + 
Sbjct: 114 GAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLD 173

Query: 221 VVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAA 280
            + +L+  G D N  +  GNT LH+A   G   V+  L+D G  + ++N +G T LH AA
Sbjct: 174 ALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAA 233

Query: 281 ASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGN 340
             +H   C++LL+  G+ VN  ++   + LH  AL G    S+ +I +G   +  D  G 
Sbjct: 234 GGSHPD-CVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGA 292

Query: 341 TPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDT 400
           +PLH+A R+    L+  LI S +D          PLHLAA   + D    LL +G D++ 
Sbjct: 293 SPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNL 352

Query: 401 PDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGR 439
            D  G+T L  A    ++  +++++       K D+F R
Sbjct: 353 RDKQGKTALAVAVRSNHVSLVDMII-------KADRFYR 384



 Score =  149 bits (377), Expect = 1e-35
 Identities = 111/383 (28%), Positives = 175/383 (45%), Gaps = 27/383 (7%)

Query: 144 LHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKD 203
           LH AA   +   ++ L+ R  N  A +   R A+HWAA  GH + V+LL+ H A V  +D
Sbjct: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78

Query: 204 KKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGA 263
                                   +G        +G   L ++ + G   ++  L++ GA
Sbjct: 79  A-----------------------VGALTEARLCFGMNALLLSAWFGHLRILQILVNSGA 115

Query: 264 IVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD--GKTPLHMTALHGRFSR 321
            ++ +++ G T LH AA   H  + L  ++ +  DV +   D  G+T  H  A HG+   
Sbjct: 116 KIHCESKDGLTLLHCAAQKGHVPV-LAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDA 174

Query: 322 SQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAAL 381
              ++ SG   + +DK GNT LH+AA  GH  ++  L+  G D  ++   G+  LH AA 
Sbjct: 175 LDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAG 234

Query: 382 SGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSP 441
               DC + LL +G  ++       +CLH AA  G+ +   +L++ G   N  D  G SP
Sbjct: 235 GSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASP 294

Query: 442 LHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIR 501
           LH A  +     +  L+ S + VN +D R  TPLH AA         + LL    +  +R
Sbjct: 295 LHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQ-DIADMLLIAGVDLNLR 353

Query: 502 DKQGYNAVHYSAAYGHRLCLQLI 524
           DKQG  A+  +    H   + +I
Sbjct: 354 DKQGKTALAVAVRSNHVSLVDMI 376



 Score =  141 bits (355), Expect = 4e-33
 Identities = 110/371 (29%), Positives = 179/371 (48%), Gaps = 24/371 (6%)

Query: 554 LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 613
           LH AA   +   ++ L+   ++   RN  GR  L  AA  GH + V +L+   A++  +D
Sbjct: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78

Query: 614 YILKRTPIHA---------AATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNG 664
            +   T             +A  GH   L++L+ +      +  +  +G T L  +   G
Sbjct: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAK---IHCESKDGLTLLHCAAQKG 135

Query: 665 HTDCVYSLLNKGANV--DAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTP 722
           H   +  ++    +V  D  DK GRTA HR A  G  + +D L+  G    ++D  G T 
Sbjct: 136 HVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTA 195

Query: 723 IHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLE--QEV 780
           +HL+A  GH+ VL  L+     ++   A     G TALH A    H  CV+LLL     V
Sbjct: 196 LHLAAGRGHMAVLQRLVDIGLDLEEQNA----EGLTALHSAAGGSHPDCVQLLLRAGSTV 251

Query: 781 FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQ 840
              T+ N  S LH A ++ +E  + +LI   G +  N  D +G +PLH A   +    ++
Sbjct: 252 NALTQKN-LSCLHYAALSGSEDVSRVLIHAGGCA--NVVDHQGASPLHLAVRHNFPALVR 308

Query: 841 LLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSK 900
           LL++ ++ VN+VD+  +TPL +AAE+   +  +ML+  A  +L L+D    TAL +A   
Sbjct: 309 LLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLL-IAGVDLNLRDKQGKTALAVAVRS 367

Query: 901 GHETSALLILE 911
            H +   +I++
Sbjct: 368 NHVSLVDMIIK 378



 Score =  123 bits (308), Expect = 1e-27
 Identities = 101/359 (28%), Positives = 167/359 (46%), Gaps = 23/359 (6%)

Query: 533 LMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLD----------VRNSS 582
           + E  G  + + + N      LH AA  GH QA+ +L++    +D           R   
Sbjct: 31  MQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCF 90

Query: 583 GRTPLDLAAFKGHVECVDVLINQGASILV--KDYILKRTPIHAAATNGHSECLRLLIGNA 640
           G   L L+A+ GH+  + +L+N GA I    KD +   T +H AA  GH   L  ++ + 
Sbjct: 91  GMNALLLSAWFGHLRILQILVNSGAKIHCESKDGL---TLLHCAAQKGHVPVLAFIMEDL 147

Query: 641 EPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEE 700
           E   A+D  D  G+T    +  +G  D +  L+  G + + KDK G TALH  A  GH  
Sbjct: 148 EDV-ALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMA 206

Query: 701 CVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTAL 760
            +  L+  G     +++ G T +H +A   H   +  LL++ ++++A          + L
Sbjct: 207 VLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNA----LTQKNLSCL 262

Query: 761 HWACYNGHETCVELLLEQE-VFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNAT 819
           H+A  +G E    +L+         +    SPLH AV ++      +LI++   S VNA 
Sbjct: 263 HYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINS--DSDVNAV 320

Query: 820 DSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSS 878
           D++ +TPLH AA     +   +LL     +N  D  GKT L +A  +   + V+M++ +
Sbjct: 321 DNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKA 379



 Score =  121 bits (304), Expect = 3e-27
 Identities = 115/409 (28%), Positives = 178/409 (43%), Gaps = 58/409 (14%)

Query: 343 LHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPD 402
           LH AAR  +   +  LI    +T  R   G   LH AA +G     R LL     +D  D
Sbjct: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78

Query: 403 D----------FGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQ 452
                      FG   L  +A  G+L  L +L+N+GA  + + K G + LH AA      
Sbjct: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAA------ 132

Query: 453 CLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYS 512
                           ++G  P+      D +   L+++          DK G  A H +
Sbjct: 133 ----------------QKGHVPVLAFIMEDLEDVALDHV----------DKLGRTAFHRA 166

Query: 513 AAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQS 572
           A +G     QL A    LD L+ +     + D +       LHLAA  GH   L+ LV  
Sbjct: 167 AEHG-----QLDA----LDFLVGSGCDHNVKDKEGNTA---LHLAAGRGHMAVLQRLVDI 214

Query: 573 LLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSEC 632
            LDL+ +N+ G T L  AA   H +CV +L+  G+++         + +H AA +G  + 
Sbjct: 215 GLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQ-KNLSCLHYAALSGSEDV 273

Query: 633 LRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHR 692
            R+LI      N VD Q   G +PL L+V +     V  L+N  ++V+A D   +T LH 
Sbjct: 274 SRVLIHAGGCANVVDHQ---GASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHL 330

Query: 693 GAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQS 741
            A    ++  D LL  G    LRD +G+T + ++    H+ ++  ++++
Sbjct: 331 AAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKA 379



 Score =  119 bits (298), Expect = 1e-26
 Identities = 88/297 (29%), Positives = 146/297 (49%), Gaps = 3/297 (1%)

Query: 48  AAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADV--NARDK 105
           +A+ G   I+++L+ SGA+++ +    LT LH A        +  +++   DV  +  DK
Sbjct: 98  SAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDK 157

Query: 106 NWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGAN 165
             +T  H AA +  +   + LV    + NV D+ G TALH AA  GH  +++ L+  G +
Sbjct: 158 LGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLD 217

Query: 166 INAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYL 225
           +   + +   A+H AA   H + V+LL+  G+ V    +K+ + LH AA SG   V + L
Sbjct: 218 LEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVL 277

Query: 226 LDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHG 285
           +  G   N  +  G +PLH+A  +    +V  LI+  + VN  + +  TPLH AA     
Sbjct: 278 IHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQ 337

Query: 286 ALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTP 342
            +   LL+  G D+N++ K GKT L +       S    II++      E  + + P
Sbjct: 338 DIADMLLIA-GVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKADRFYRWEKDHPSDP 393



 Score =  116 bits (290), Expect = 1e-25
 Identities = 73/266 (27%), Positives = 129/266 (48%), Gaps = 2/266 (0%)

Query: 24  VRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLI--LSGARVNAKDSKWLTPLHRA 81
           ++ L+     ++ +  +  T LH AA  G   ++  ++  L    ++  D    T  HRA
Sbjct: 107 LQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRA 166

Query: 82  VASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGR 141
                 +A+  L+    D N +DK   T LH+AA    +   + LV +  ++   +  G 
Sbjct: 167 AEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGL 226

Query: 142 TALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTC 201
           TALH AA   H + V+LLL  G+ +NA  +K+   +H+AA  G  +V ++L+  G     
Sbjct: 227 TALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANV 286

Query: 202 KDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDC 261
            D +  +PLH A      ++V+ L++   D+N  +    TPLH+A  +    + + L+  
Sbjct: 287 VDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIA 346

Query: 262 GAIVNQKNEKGFTPLHFAAASTHGAL 287
           G  +N ++++G T L  A  S H +L
Sbjct: 347 GVDLNLRDKQGKTALAVAVRSNHVSL 372



 Score =  108 bits (270), Expect = 3e-23
 Identities = 108/409 (26%), Positives = 171/409 (41%), Gaps = 71/409 (17%)

Query: 590 AAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQ 649
           AA + +V  +  LI +  +   ++++  R  +H AA  GH + +RLL+   E + AVD +
Sbjct: 22  AARQNNVGRMQELIGRRVNTRARNHV-GRVALHWAAGAGHEQAVRLLL---EHEAAVDEE 77

Query: 650 DGNG----------QTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGH- 698
           D  G             L+LS   GH   +  L+N GA +  + K G T LH  A  GH 
Sbjct: 78  DAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHV 137

Query: 699 -------EECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPAT 751
                  E+  D  L H       D  GRT  H +A  G +  L  L+ S    +     
Sbjct: 138 PVLAFIMEDLEDVALDHV------DKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVK--- 188

Query: 752 ADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTL 811
            D  G TALH A   GH   ++ L++                                 +
Sbjct: 189 -DKEGNTALHLAAGRGHMAVLQRLVD---------------------------------I 214

Query: 812 GASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNT 871
           G  +    +++G T LH+AA   H +C+QLLL   + VN++     + L  AA +G  + 
Sbjct: 215 GLDL-EEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDV 273

Query: 872 VEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLH 931
             +L+ +      + D+   + LHLA          L++   +D   +NA +   QTPLH
Sbjct: 274 SRVLIHAGGCA-NVVDHQGASPLHLAVRHNFPALVRLLINSDSD---VNAVDNRQQTPLH 329

Query: 932 VAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALIL 980
           +AA +    +   LL  G  +   D+ G T ALA A   +    + +I+
Sbjct: 330 LAAEHAWQDIADMLLIAGVDLNLRDKQGKT-ALAVAVRSNHVSLVDMII 377



 Score =  102 bits (254), Expect = 2e-21
 Identities = 69/230 (30%), Positives = 106/230 (46%), Gaps = 2/230 (0%)

Query: 32  EDVNFQDNEK--RTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEA 89
           EDV     +K  RT  H AA  G  + ++ L+ SG   N KD +  T LH A        
Sbjct: 148 EDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAV 207

Query: 90  VQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAF 149
           +Q L+    D+  ++    T LH AA      C + L+   S VN   +   + LH+AA 
Sbjct: 208 LQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAAL 267

Query: 150 SGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTP 209
           SG  ++ ++L+  G   N  D +    +H A       +V+LL++  ++V   D +  TP
Sbjct: 268 SGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTP 327

Query: 210 LHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELI 259
           LH AA      +   LL  GVD+N  +  G T L VA  +    +V+ +I
Sbjct: 328 LHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377



 Score = 93.6 bits (231), Expect = 9e-19
 Identities = 59/213 (27%), Positives = 106/213 (49%)

Query: 14  QAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSK 73
           +A  +G  D +  L+    D N +D E  T LH AA  G   +++ L+  G  +  ++++
Sbjct: 165 RAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAE 224

Query: 74  WLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNV 133
            LT LH A      + VQ+LL+  + VNA  +   + LH AA + +   +  L+      
Sbjct: 225 GLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCA 284

Query: 134 NVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLV 193
           NV D  G + LH A       +V+LL++  +++NA D + +  +H AA     ++  +L+
Sbjct: 285 NVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLL 344

Query: 194 SHGAEVTCKDKKSYTPLHAAASSGMISVVKYLL 226
             G ++  +DK+  T L  A  S  +S+V  ++
Sbjct: 345 IAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 49/150 (32%), Positives = 77/150 (51%)

Query: 11  SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
           +L  A     PD V+ L+     VN    +  + LH AA  G  ++  +LI +G   N  
Sbjct: 228 ALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVV 287

Query: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
           D +  +PLH AV       V++L+   +DVNA D   QTPLH+AA +     A+ L+   
Sbjct: 288 DHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAG 347

Query: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLL 160
            ++N+ D+ G+TAL  A  S H  +V +++
Sbjct: 348 VDLNLRDKQGKTALAVAVRSNHVSLVDMII 377



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 29/81 (35%), Positives = 45/81 (55%)

Query: 15  AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 74
           A+ +  P  VR LI    DVN  DN ++TPLH AA     +I ++L+++G  +N +D + 
Sbjct: 298 AVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQG 357

Query: 75  LTPLHRAVASCSEEAVQVLLK 95
            T L  AV S     V +++K
Sbjct: 358 KTALAVAVRSNHVSLVDMIIK 378


>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
          Length = 835

 Score =  164 bits (415), Expect = 4e-40
 Identities = 112/347 (32%), Positives = 171/347 (49%), Gaps = 17/347 (4%)

Query: 29  FKKEDVNFQDNEKRTPLHAAAYLGDAEI-IELLILSGARVNAKDSKWLTPLHRAVASCSE 87
           F K ++N++     + LH     G  +  I  L+L G R +       T LH AV   + 
Sbjct: 55  FSKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNA 114

Query: 88  EAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHA 147
           E +  LL   AD+        T LHIA     ++ A+ L+   +NVN+ D    T LH A
Sbjct: 115 ELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIA 174

Query: 148 AFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHG--AEVTCKDKK 205
           A+ GH ++ +LLL  GA++N   +   R +H A+  G + + KLL+  G  A+V  +D +
Sbjct: 175 AYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNE 234

Query: 206 SYTPLHAAASSGMISVVKYLL--DLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGA 263
            + PLH  +  G   +VKYLL  DL V  +  N YG+TPLH+ACYNG+  V  E+I    
Sbjct: 235 DHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISG 294

Query: 264 IVNQKNEKGFTPLHFAAASTHGA---LCLELLVGNGADVNMKSKDGKTPLHMTALHGRFS 320
             +   E  F+   F +A T+G    L   LL  N  ++N + +DG T LH    HG   
Sbjct: 295 TESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIR 354

Query: 321 RSQTIIQSGA---VIDCE------DKNGNTPLHIAARYGHELLINTL 358
             Q ++ +GA   ++ C+      +K+  T L  A   GH+ ++  L
Sbjct: 355 LVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401



 Score =  116 bits (290), Expect = 1e-25
 Identities = 84/269 (31%), Positives = 126/269 (46%), Gaps = 7/269 (2%)

Query: 138 RAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGA 197
           R G TALH A +  + E++  LL  GA+I         A+H A   GH+E   +L+ HGA
Sbjct: 99  RNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGA 158

Query: 198 EVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNE 257
            V  +D   +TPLH AA  G   V + LL  G D+N     G+ PLH+A   G   +   
Sbjct: 159 NVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKL 218

Query: 258 LIDCG--AIVNQKNEKGFTPLHFAAASTHGALCLELLVGN-GADVNMKSKDGKTPLHMTA 314
           L++ G  A VN ++ +   PLHF +   H  +   LL  +     ++ +  G TPLH+  
Sbjct: 219 LMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLAC 278

Query: 315 LHGRFSRSQTIIQSGAVIDCEDKN--GNTPLHIAARYGHEL-LINTLITSGA-DTAKRGI 370
            +G+F  ++ IIQ         +N    T  H A  YG  + L+  L+     +   +G 
Sbjct: 279 YNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGR 338

Query: 371 HGMFPLHLAALSGFSDCCRKLLSSGFDID 399
            G   LH A   G     + LL +G D++
Sbjct: 339 DGHTGLHSACYHGHIRLVQFLLDNGADMN 367



 Score =  115 bits (288), Expect = 2e-25
 Identities = 82/260 (31%), Positives = 130/260 (50%), Gaps = 8/260 (3%)

Query: 15  AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 74
           A++  + + + +L+    D+        T LH A   G  E  ++L+  GA VN +D+ +
Sbjct: 108 AVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVF 167

Query: 75  LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVP--LLSN 132
            TPLH A     E+  ++LLK  ADVN   +    PLH+A+A   +  A+ L+     ++
Sbjct: 168 FTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKAD 227

Query: 133 VNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANI--NAFDKKDRRAIHWAAYMGHIEVVK 190
           VN  D      LH  +  GH ++VK LL     +  +  +      +H A Y G  EV K
Sbjct: 228 VNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAK 287

Query: 191 --LLVSHGAEVTCKDKKSYTPLHAAASSG-MISVVKYLLDLGV-DMNEPNAYGNTPLHVA 246
             + +S    +T ++  S T  H+A + G  I +VK+LLD  V ++N     G+T LH A
Sbjct: 288 EIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSA 347

Query: 247 CYNGQDVVVNELIDCGAIVN 266
           CY+G   +V  L+D GA +N
Sbjct: 348 CYHGHIRLVQFLLDNGADMN 367



 Score =  113 bits (282), Expect = 1e-24
 Identities = 103/358 (28%), Positives = 163/358 (45%), Gaps = 30/358 (8%)

Query: 633 LRLLIGNAEPQNAVDI--QDGNGQTPLMLS-VLNGHTDCVYSLLNKGANVDAKDKWGRTA 689
           LR + G+ E  + V++  +  NG + L L  +  G    + +L+ KG       + G TA
Sbjct: 45  LRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTA 104

Query: 690 LHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANP 749
           LH      + E + +LL  GA        G T +H++   GH+     LLQ  A+++   
Sbjct: 105 LHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQD 164

Query: 750 ATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFS-PLHCAVINDNEGAAEMLI 808
           A      +T LH A Y GHE    LLL+        G     PLH A        A++L+
Sbjct: 165 AVF----FTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLM 220

Query: 809 DTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQV--NSVDSTGKTPLMMAAEN 866
           +    + VNA D++   PLH  +   H + ++ LL  + +V  + V+  G TPL +A  N
Sbjct: 221 EEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYN 280

Query: 867 GQTNTV-EMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAA 925
           G+     E++  S +  LT ++    TA H AC+ G    ++ +++ + D+N+IN  +  
Sbjct: 281 GKFEVAKEIIQISGTESLTKENIFSETAFHSACTYG---KSIDLVKFLLDQNVININHQG 337

Query: 926 L--QTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPN-----KDVADCL 976
               T LH A  +G   +VQ LL  GA +  V         AC P+     KD   CL
Sbjct: 338 RDGHTGLHSACYHGHIRLVQFLLDNGADMNLV---------ACDPSRSSGEKDEQTCL 386



 Score =  112 bits (280), Expect = 2e-24
 Identities = 93/319 (29%), Positives = 157/319 (49%), Gaps = 18/319 (5%)

Query: 298 DVNMKSKDGKTPLHMTAL-HGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLIN 356
           ++N ++++G + LH+  +  G+ S  +T++  G       +NG T LH+A    +  LI 
Sbjct: 59  NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 118

Query: 357 TLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGG 416
           +L+ SGAD  + G  G+  LH+A ++G  +    LL  G +++  D    T LH AA  G
Sbjct: 119 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 178

Query: 417 NLECLNLLLNTGADFNKKDKFGRSPLHYAAAN--CNYQCLFALVGSGASVNDLDERGCTP 474
           + +   LLL  GAD N   + G  PLH A+A    N   L    GS A VN  D     P
Sbjct: 179 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 238

Query: 475 LHYAATSDTDGKCLEYLLRND--ANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDV 532
           LH+ +        ++YLL++D    P + +  G   +H  A Y  +     +A E     
Sbjct: 239 LHFCSRFG-HHDIVKYLLQSDLEVQPHVVNIYGDTPLHL-ACYNGKF---EVAKE----- 288

Query: 533 LMETSGTDMLSDSDNRATISPLHLAAYHGHHQALE--VLVQSLLDLDVRNSSGRTPLDLA 590
           +++ SGT+ L+  +N  + +  H A  +G    L   +L Q++++++ +   G T L  A
Sbjct: 289 IIQISGTESLT-KENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSA 347

Query: 591 AFKGHVECVDVLINQGASI 609
            + GH+  V  L++ GA +
Sbjct: 348 CYHGHIRLVQFLLDNGADM 366



 Score =  108 bits (271), Expect = 2e-23
 Identities = 93/343 (27%), Positives = 143/343 (41%), Gaps = 55/343 (16%)

Query: 548 RATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGA 607
           R   + LHLA Y  + + +  L+ S  D+      G T L +A   GH+E  DVL+  GA
Sbjct: 99  RNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGA 158

Query: 608 SILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTD 667
           ++ ++D +   TP+H AA  GH +  RL                                
Sbjct: 159 NVNIQDAVF-FTPLHIAAYYGHEQVTRL-------------------------------- 185

Query: 668 CVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLL--RDSRGRTPIHL 725
               LL  GA+V+   + G   LH  +  G       L++ G+K  +  +D+    P+H 
Sbjct: 186 ----LLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHF 241

Query: 726 SAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNG-HETCVELLLEQEVFQKT 784
            +  GH  ++  LLQS   ++  P   + +G T LH ACYNG  E   E++        T
Sbjct: 242 CSRFGHHDIVKYLLQS--DLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLT 299

Query: 785 EGNAFS--PLHCA-VINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQL 841
           + N FS    H A     +    + L+D      +N     G T LH+A +  H+  +Q 
Sbjct: 300 KENIFSETAFHSACTYGKSIDLVKFLLDQ-NVININHQGRDGHTGLHSACYHGHIRLVQF 358

Query: 842 LLSHNAQVNSV---------DSTGKTPLMMAAENGQTNTVEML 875
           LL + A +N V         +   +T LM A E G    V +L
Sbjct: 359 LLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 86/337 (25%), Positives = 147/337 (43%), Gaps = 40/337 (11%)

Query: 457 LVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYG 516
           L+  G   + L   G T LH A   D + + +  LL + A+       G  A+H +   G
Sbjct: 87  LMLKGLRPSRLTRNGFTALHLAVYKD-NAELITSLLHSGADIQQVGYGGLTALHIATIAG 145

Query: 517 HRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDL 576
           H             DVL++      + D+      +PLH+AAY+GH Q   +L++   D+
Sbjct: 146 HL---------EAADVLLQHGANVNIQDA---VFFTPLHIAAYYGHEQVTRLLLKFGADV 193

Query: 577 DVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV-----KDYILKRTPIHAAATNGHSE 631
           +V    G  PL LA+ KG +    +L+ +G+   V     +D++    P+H  +  GH +
Sbjct: 194 NVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHV----PLHFCSRFGHHD 249

Query: 632 CLRLLIGNAEPQNAVDIQDG----NGQTPLMLSVLNGHTDCVYSLLNKGA--NVDAKDKW 685
            ++ L+     Q+ +++Q       G TPL L+  NG  +    ++      ++  ++ +
Sbjct: 250 IVKYLL-----QSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIF 304

Query: 686 GRTALHRGAVTGHE-ECVDALLQHGAKCLLRDSR-GRTPIHLSAACGHIGVLGALLQSAA 743
             TA H     G   + V  LL      +    R G T +H +   GHI ++  LL + A
Sbjct: 305 SETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGA 364

Query: 744 SM-----DANPATADNHGYTALHWACYNGHETCVELL 775
            M     D + ++ +    T L WA   GH+  V LL
Sbjct: 365 DMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 91/353 (25%), Positives = 146/353 (41%), Gaps = 26/353 (7%)

Query: 265 VNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQT 324
           +N + E G + LH           +  L+  G   +  +++G T LH+           +
Sbjct: 60  LNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITS 119

Query: 325 IIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGF 384
           ++ SGA I      G T LHIA   GH    + L+  GA+   +      PLH+AA  G 
Sbjct: 120 LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 179

Query: 385 SDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTG--ADFNKKDKFGRSPL 442
               R LL  G D++   + G   LH A+A G L    LL+  G  AD N +D     PL
Sbjct: 180 EQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPL 239

Query: 443 HYAAANCNYQCLFALVGSGASVND--LDERGCTPLHYAATSDTDGKCLEYLLRNDANPGI 500
           H+ +   ++  +  L+ S   V    ++  G TPLH A  +       E +  +      
Sbjct: 240 HFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLT 299

Query: 501 RDK-QGYNAVHYSAAYGHRLCL-QLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAA 558
           ++      A H +  YG  + L + +  +  +++           +   R   + LH A 
Sbjct: 300 KENIFSETAFHSACTYGKSIDLVKFLLDQNVINI-----------NHQGRDGHTGLHSAC 348

Query: 559 YHGHHQALEVLVQSLLDL-----DVRNSSG----RTPLDLAAFKGHVECVDVL 602
           YHGH + ++ L+ +  D+     D   SSG    +T L  A  KGH   V +L
Sbjct: 349 YHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 94/348 (27%), Positives = 139/348 (39%), Gaps = 57/348 (16%)

Query: 371 HGMFPLHLAALSGFSDC-CRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGA 429
           +G+  LHL  + G      R L+  G         G T LH A    N E +  LL++GA
Sbjct: 66  NGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGA 125

Query: 430 DFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLE 489
           D  +    G + LH A    + +    L+  GA+VN  D    TPLH AA    + +   
Sbjct: 126 DIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHE-QVTR 184

Query: 490 YLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRA 549
            LL+  A+  +  + G   +H ++A G     +L         LME      ++  DN  
Sbjct: 185 LLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKL---------LMEEGSKADVNAQDNED 235

Query: 550 TISPLHLAAYHGHHQALEVLVQSLLDLD--VRNSSGRTPLDLAAFKGHVECVDVLIN-QG 606
            + PLH  +  GHH  ++ L+QS L++   V N  G TPL LA + G  E    +I   G
Sbjct: 236 HV-PLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISG 294

Query: 607 ASILVKDYILKRTP-----------------------------------IHAAATNGHSE 631
              L K+ I   T                                    +H+A  +GH  
Sbjct: 295 TESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIR 354

Query: 632 CLRLLIGNAEPQN--AVDIQDGNG----QTPLMLSVLNGHTDCVYSLL 673
            ++ L+ N    N  A D    +G    QT LM +   GH D + +LL
Sbjct: 355 LVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGH-DAIVTLL 401


>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
          Length = 936

 Score =  164 bits (415), Expect = 4e-40
 Identities = 112/347 (32%), Positives = 171/347 (49%), Gaps = 17/347 (4%)

Query: 29  FKKEDVNFQDNEKRTPLHAAAYLGDAEI-IELLILSGARVNAKDSKWLTPLHRAVASCSE 87
           F K ++N++     + LH     G  +  I  L+L G R +       T LH AV   + 
Sbjct: 156 FSKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNA 215

Query: 88  EAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHA 147
           E +  LL   AD+        T LHIA     ++ A+ L+   +NVN+ D    T LH A
Sbjct: 216 ELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIA 275

Query: 148 AFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHG--AEVTCKDKK 205
           A+ GH ++ +LLL  GA++N   +   R +H A+  G + + KLL+  G  A+V  +D +
Sbjct: 276 AYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNE 335

Query: 206 SYTPLHAAASSGMISVVKYLL--DLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGA 263
            + PLH  +  G   +VKYLL  DL V  +  N YG+TPLH+ACYNG+  V  E+I    
Sbjct: 336 DHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISG 395

Query: 264 IVNQKNEKGFTPLHFAAASTHGA---LCLELLVGNGADVNMKSKDGKTPLHMTALHGRFS 320
             +   E  F+   F +A T+G    L   LL  N  ++N + +DG T LH    HG   
Sbjct: 396 TESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIR 455

Query: 321 RSQTIIQSGA---VIDCE------DKNGNTPLHIAARYGHELLINTL 358
             Q ++ +GA   ++ C+      +K+  T L  A   GH+ ++  L
Sbjct: 456 LVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 502



 Score =  116 bits (290), Expect = 1e-25
 Identities = 84/269 (31%), Positives = 126/269 (46%), Gaps = 7/269 (2%)

Query: 138 RAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGA 197
           R G TALH A +  + E++  LL  GA+I         A+H A   GH+E   +L+ HGA
Sbjct: 200 RNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGA 259

Query: 198 EVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNE 257
            V  +D   +TPLH AA  G   V + LL  G D+N     G+ PLH+A   G   +   
Sbjct: 260 NVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKL 319

Query: 258 LIDCG--AIVNQKNEKGFTPLHFAAASTHGALCLELLVGN-GADVNMKSKDGKTPLHMTA 314
           L++ G  A VN ++ +   PLHF +   H  +   LL  +     ++ +  G TPLH+  
Sbjct: 320 LMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLAC 379

Query: 315 LHGRFSRSQTIIQSGAVIDCEDKN--GNTPLHIAARYGHEL-LINTLITSGA-DTAKRGI 370
            +G+F  ++ IIQ         +N    T  H A  YG  + L+  L+     +   +G 
Sbjct: 380 YNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGR 439

Query: 371 HGMFPLHLAALSGFSDCCRKLLSSGFDID 399
            G   LH A   G     + LL +G D++
Sbjct: 440 DGHTGLHSACYHGHIRLVQFLLDNGADMN 468



 Score =  115 bits (288), Expect = 2e-25
 Identities = 82/260 (31%), Positives = 130/260 (50%), Gaps = 8/260 (3%)

Query: 15  AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 74
           A++  + + + +L+    D+        T LH A   G  E  ++L+  GA VN +D+ +
Sbjct: 209 AVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVF 268

Query: 75  LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVP--LLSN 132
            TPLH A     E+  ++LLK  ADVN   +    PLH+A+A   +  A+ L+     ++
Sbjct: 269 FTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKAD 328

Query: 133 VNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANI--NAFDKKDRRAIHWAAYMGHIEVVK 190
           VN  D      LH  +  GH ++VK LL     +  +  +      +H A Y G  EV K
Sbjct: 329 VNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAK 388

Query: 191 --LLVSHGAEVTCKDKKSYTPLHAAASSG-MISVVKYLLDLGV-DMNEPNAYGNTPLHVA 246
             + +S    +T ++  S T  H+A + G  I +VK+LLD  V ++N     G+T LH A
Sbjct: 389 EIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSA 448

Query: 247 CYNGQDVVVNELIDCGAIVN 266
           CY+G   +V  L+D GA +N
Sbjct: 449 CYHGHIRLVQFLLDNGADMN 468



 Score =  113 bits (282), Expect = 1e-24
 Identities = 103/358 (28%), Positives = 163/358 (45%), Gaps = 30/358 (8%)

Query: 633 LRLLIGNAEPQNAVDI--QDGNGQTPLMLS-VLNGHTDCVYSLLNKGANVDAKDKWGRTA 689
           LR + G+ E  + V++  +  NG + L L  +  G    + +L+ KG       + G TA
Sbjct: 146 LRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTA 205

Query: 690 LHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANP 749
           LH      + E + +LL  GA        G T +H++   GH+     LLQ  A+++   
Sbjct: 206 LHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQD 265

Query: 750 ATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFS-PLHCAVINDNEGAAEMLI 808
           A      +T LH A Y GHE    LLL+        G     PLH A        A++L+
Sbjct: 266 AVF----FTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLM 321

Query: 809 DTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQV--NSVDSTGKTPLMMAAEN 866
           +    + VNA D++   PLH  +   H + ++ LL  + +V  + V+  G TPL +A  N
Sbjct: 322 EEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYN 381

Query: 867 GQTNTV-EMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAA 925
           G+     E++  S +  LT ++    TA H AC+ G    ++ +++ + D+N+IN  +  
Sbjct: 382 GKFEVAKEIIQISGTESLTKENIFSETAFHSACTYG---KSIDLVKFLLDQNVININHQG 438

Query: 926 L--QTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPN-----KDVADCL 976
               T LH A  +G   +VQ LL  GA +  V         AC P+     KD   CL
Sbjct: 439 RDGHTGLHSACYHGHIRLVQFLLDNGADMNLV---------ACDPSRSSGEKDEQTCL 487



 Score =  112 bits (280), Expect = 2e-24
 Identities = 93/319 (29%), Positives = 157/319 (49%), Gaps = 18/319 (5%)

Query: 298 DVNMKSKDGKTPLHMTAL-HGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLIN 356
           ++N ++++G + LH+  +  G+ S  +T++  G       +NG T LH+A    +  LI 
Sbjct: 160 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 219

Query: 357 TLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGG 416
           +L+ SGAD  + G  G+  LH+A ++G  +    LL  G +++  D    T LH AA  G
Sbjct: 220 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 279

Query: 417 NLECLNLLLNTGADFNKKDKFGRSPLHYAAAN--CNYQCLFALVGSGASVNDLDERGCTP 474
           + +   LLL  GAD N   + G  PLH A+A    N   L    GS A VN  D     P
Sbjct: 280 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 339

Query: 475 LHYAATSDTDGKCLEYLLRND--ANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDV 532
           LH+ +        ++YLL++D    P + +  G   +H  A Y  +     +A E     
Sbjct: 340 LHFCSRFG-HHDIVKYLLQSDLEVQPHVVNIYGDTPLHL-ACYNGKF---EVAKE----- 389

Query: 533 LMETSGTDMLSDSDNRATISPLHLAAYHGHHQALE--VLVQSLLDLDVRNSSGRTPLDLA 590
           +++ SGT+ L+  +N  + +  H A  +G    L   +L Q++++++ +   G T L  A
Sbjct: 390 IIQISGTESLT-KENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSA 448

Query: 591 AFKGHVECVDVLINQGASI 609
            + GH+  V  L++ GA +
Sbjct: 449 CYHGHIRLVQFLLDNGADM 467



 Score =  108 bits (271), Expect = 2e-23
 Identities = 93/343 (27%), Positives = 143/343 (41%), Gaps = 55/343 (16%)

Query: 548 RATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGA 607
           R   + LHLA Y  + + +  L+ S  D+      G T L +A   GH+E  DVL+  GA
Sbjct: 200 RNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGA 259

Query: 608 SILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTD 667
           ++ ++D +   TP+H AA  GH +  RL                                
Sbjct: 260 NVNIQDAVF-FTPLHIAAYYGHEQVTRL-------------------------------- 286

Query: 668 CVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLL--RDSRGRTPIHL 725
               LL  GA+V+   + G   LH  +  G       L++ G+K  +  +D+    P+H 
Sbjct: 287 ----LLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHF 342

Query: 726 SAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNG-HETCVELLLEQEVFQKT 784
            +  GH  ++  LLQS   ++  P   + +G T LH ACYNG  E   E++        T
Sbjct: 343 CSRFGHHDIVKYLLQS--DLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLT 400

Query: 785 EGNAFS--PLHCA-VINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQL 841
           + N FS    H A     +    + L+D      +N     G T LH+A +  H+  +Q 
Sbjct: 401 KENIFSETAFHSACTYGKSIDLVKFLLDQ-NVININHQGRDGHTGLHSACYHGHIRLVQF 459

Query: 842 LLSHNAQVNSV---------DSTGKTPLMMAAENGQTNTVEML 875
           LL + A +N V         +   +T LM A E G    V +L
Sbjct: 460 LLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 502



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 86/337 (25%), Positives = 147/337 (43%), Gaps = 40/337 (11%)

Query: 457 LVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYG 516
           L+  G   + L   G T LH A   D + + +  LL + A+       G  A+H +   G
Sbjct: 188 LMLKGLRPSRLTRNGFTALHLAVYKD-NAELITSLLHSGADIQQVGYGGLTALHIATIAG 246

Query: 517 HRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDL 576
           H             DVL++      + D+      +PLH+AAY+GH Q   +L++   D+
Sbjct: 247 HL---------EAADVLLQHGANVNIQDA---VFFTPLHIAAYYGHEQVTRLLLKFGADV 294

Query: 577 DVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV-----KDYILKRTPIHAAATNGHSE 631
           +V    G  PL LA+ KG +    +L+ +G+   V     +D++    P+H  +  GH +
Sbjct: 295 NVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHV----PLHFCSRFGHHD 350

Query: 632 CLRLLIGNAEPQNAVDIQDG----NGQTPLMLSVLNGHTDCVYSLLNKGA--NVDAKDKW 685
            ++ L+     Q+ +++Q       G TPL L+  NG  +    ++      ++  ++ +
Sbjct: 351 IVKYLL-----QSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIF 405

Query: 686 GRTALHRGAVTGHE-ECVDALLQHGAKCLLRDSR-GRTPIHLSAACGHIGVLGALLQSAA 743
             TA H     G   + V  LL      +    R G T +H +   GHI ++  LL + A
Sbjct: 406 SETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGA 465

Query: 744 SM-----DANPATADNHGYTALHWACYNGHETCVELL 775
            M     D + ++ +    T L WA   GH+  V LL
Sbjct: 466 DMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 502



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 91/353 (25%), Positives = 146/353 (41%), Gaps = 26/353 (7%)

Query: 265 VNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQT 324
           +N + E G + LH           +  L+  G   +  +++G T LH+           +
Sbjct: 161 LNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITS 220

Query: 325 IIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGF 384
           ++ SGA I      G T LHIA   GH    + L+  GA+   +      PLH+AA  G 
Sbjct: 221 LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 280

Query: 385 SDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTG--ADFNKKDKFGRSPL 442
               R LL  G D++   + G   LH A+A G L    LL+  G  AD N +D     PL
Sbjct: 281 EQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPL 340

Query: 443 HYAAANCNYQCLFALVGSGASVND--LDERGCTPLHYAATSDTDGKCLEYLLRNDANPGI 500
           H+ +   ++  +  L+ S   V    ++  G TPLH A  +       E +  +      
Sbjct: 341 HFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLT 400

Query: 501 RDK-QGYNAVHYSAAYGHRLCL-QLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAA 558
           ++      A H +  YG  + L + +  +  +++           +   R   + LH A 
Sbjct: 401 KENIFSETAFHSACTYGKSIDLVKFLLDQNVINI-----------NHQGRDGHTGLHSAC 449

Query: 559 YHGHHQALEVLVQSLLDL-----DVRNSSG----RTPLDLAAFKGHVECVDVL 602
           YHGH + ++ L+ +  D+     D   SSG    +T L  A  KGH   V +L
Sbjct: 450 YHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 502



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 94/348 (27%), Positives = 139/348 (39%), Gaps = 57/348 (16%)

Query: 371 HGMFPLHLAALSGFSDC-CRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGA 429
           +G+  LHL  + G      R L+  G         G T LH A    N E +  LL++GA
Sbjct: 167 NGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGA 226

Query: 430 DFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLE 489
           D  +    G + LH A    + +    L+  GA+VN  D    TPLH AA    + +   
Sbjct: 227 DIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHE-QVTR 285

Query: 490 YLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRA 549
            LL+  A+  +  + G   +H ++A G     +L         LME      ++  DN  
Sbjct: 286 LLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKL---------LMEEGSKADVNAQDNED 336

Query: 550 TISPLHLAAYHGHHQALEVLVQSLLDLD--VRNSSGRTPLDLAAFKGHVECVDVLIN-QG 606
            + PLH  +  GHH  ++ L+QS L++   V N  G TPL LA + G  E    +I   G
Sbjct: 337 HV-PLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISG 395

Query: 607 ASILVKDYILKRTP-----------------------------------IHAAATNGHSE 631
              L K+ I   T                                    +H+A  +GH  
Sbjct: 396 TESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIR 455

Query: 632 CLRLLIGNAEPQN--AVDIQDGNG----QTPLMLSVLNGHTDCVYSLL 673
            ++ L+ N    N  A D    +G    QT LM +   GH D + +LL
Sbjct: 456 LVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGH-DAIVTLL 502


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
           sapiens]
          Length = 2603

 Score =  164 bits (415), Expect = 4e-40
 Identities = 139/469 (29%), Positives = 217/469 (46%), Gaps = 7/469 (1%)

Query: 52  GDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARD-KNWQTP 110
           GD   +  L++ G  VN    +  + L  A ++   E  QVLL   A+V  R  K   TP
Sbjct: 245 GDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITP 304

Query: 111 LHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFD 170
           L  AA    VK  + L+   ++VN     G TAL +A   G+ ++VK+LL  GA+I   +
Sbjct: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHN 364

Query: 171 KKDRRAIHWAAYMGHIEVVKLLVSHGAEV-TCKDKKSYTPLHAAASSGMISVVKYLLDLG 229
           +     +  A   GH+EV +LL+ +GA + T  ++   + L  A   G + +V++LL+ G
Sbjct: 365 ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAG 424

Query: 230 VDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCL 289
            D        +T L  AC +G   V   L+D GA VN   +   +PL  AA   H  L  
Sbjct: 425 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA- 483

Query: 290 ELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCE-DKNGNTPLHIAAR 348
            LL+  GA +   + +G TPL   A  G       ++  GA I+ + ++   T L +A  
Sbjct: 484 ALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACC 543

Query: 349 YGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTC 408
            G   + + LI +GAD     +    PL  AA  G  +  + LL++G ++      G T 
Sbjct: 544 GGFLEVADFLIKAGADIE---LGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600

Query: 409 LHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLD 468
           L  A   G+ +  ++LL  GAD   + + GR+PL  AA   +   +  L+  GA+VN   
Sbjct: 601 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 660

Query: 469 ERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGH 517
                 +   A +      +E LL + A+P  R K G   +  +A  GH
Sbjct: 661 ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGH 709



 Score =  160 bits (406), Expect = 4e-39
 Identities = 140/475 (29%), Positives = 208/475 (43%), Gaps = 39/475 (8%)

Query: 8   DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKR------------------------- 42
           D  SL +A   GD + VR L+ +   VN    E                           
Sbjct: 234 DNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 293

Query: 43  ---------TPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVL 93
                    TPL AAA  G  +I++LL+   A VNA+ S   T L  A A    + V+VL
Sbjct: 294 EDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVL 353

Query: 94  LKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNV-SDRAGRTALHHAAFSGH 152
           L+  A +   ++N  TPL  A +   V+ A  L+   + +N  S+    +AL  A + GH
Sbjct: 354 LESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGH 413

Query: 153 GEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHA 212
            EMV+ LL  GA+      +   A+  A   GH+EV +LL+  GA+V        +PL  
Sbjct: 414 LEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 473

Query: 213 AASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKG 272
           AA  G + +   L++ G  + E N  G TPL  A   G + +V  L+  GA +N + E+ 
Sbjct: 474 AACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEET 533

Query: 273 FTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVI 332
                  A         + L+  GAD+ +      TPL   A  G     + ++ +GA +
Sbjct: 534 QETALTLACCGGFLEVADFLIKAGADIELGC---STPLMEAAQEGHLELVKYLLAAGANV 590

Query: 333 DCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLL 392
                 G+T L  A   GH  + + L+ +GAD       G  PL  AA +G     + L+
Sbjct: 591 HATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLI 650

Query: 393 SSGFDID-TPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446
           S G +++ T  +   T L  A AGG+L  + LLL  GAD   + K G + L  AA
Sbjct: 651 SKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAA 705



 Score =  157 bits (396), Expect = 6e-38
 Identities = 173/636 (27%), Positives = 268/636 (42%), Gaps = 71/636 (11%)

Query: 55  EIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIA 114
           E    L+LSG    A D + + P  +A      EA  +    +AD     K +  P  + 
Sbjct: 148 ETASKLLLSGTADGA-DLRTVDPETQARLEALLEAAGIGKLSTAD----GKAFADPEVLR 202

Query: 115 AANKAVKCA--EALVPLL-----SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANIN 167
               +V CA  EA   L      S  N      R+ L  A   G    V+ LL  G ++N
Sbjct: 203 RLTSSVSCALDEAAAALTRMRAESTANAGQSDNRS-LAEACSEGDVNAVRKLLIEGRSVN 261

Query: 168 AFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKD-KKSYTPLHAAASSGMISVVKYLL 226
              ++    +  A   G+ E+ ++L++  A V  +  K   TPL AAA+ G + +VK LL
Sbjct: 262 EHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLL 321

Query: 227 DLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGA 286
               D+N  ++ GNT L  AC  G   VV  L++ GA +   NE G TPL  A ++ H  
Sbjct: 322 AHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVE 381

Query: 287 LCLELLVGNGADVNMKSKDGK-TPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHI 345
           +   LL+ NGA +N  S + K + L +    G     + ++++GA  + +    +T L  
Sbjct: 382 VA-RLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALME 440

Query: 346 AARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFG 405
           A   GH  +   L+ SGA           PL LAA  G  +    L+  G  ++  +D G
Sbjct: 441 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEG 500

Query: 406 RTCLHAAAAGGNLECLNLLLNTGADFN-KKDKFGRSPLHYAAANCNYQCLFALVGSGASV 464
            T L  AA  G+ E + LLL  GA+ N + ++   + L  A      +    L+ +GA +
Sbjct: 501 YTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADI 560

Query: 465 NDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLI 524
               E GC+     A  +   + ++YLL   AN       G  A+ Y+   GH       
Sbjct: 561 ----ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGH------- 609

Query: 525 ASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGR 584
                 DVL++ +G D+  +S+                                    GR
Sbjct: 610 --TDVADVLLQ-AGADLEHESE-----------------------------------GGR 631

Query: 585 TPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGN-AEPQ 643
           TPL  AA  GHV  V  LI++GA++         T +  A   GH   + LL+ + A+P 
Sbjct: 632 TPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPT 691

Query: 644 NAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANV 679
           + +     +G T L+ +   GHT  V  LL+   N+
Sbjct: 692 HRLK----DGSTMLIEAAKGGHTSVVCYLLDYPNNL 723



 Score =  157 bits (396), Expect = 6e-38
 Identities = 136/465 (29%), Positives = 209/465 (44%), Gaps = 30/465 (6%)

Query: 317 GRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHG-MFP 375
           G  +  + ++  G  ++   + G + L +A   G+  L   L+   A+   RGI G + P
Sbjct: 245 GDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITP 304

Query: 376 LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKD 435
           L  AA  G     + LL+   D++     G T L  A AGG ++ + +LL +GA     +
Sbjct: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHN 364

Query: 436 KFGRSPLHYAAANCNYQCLFALVGSGASVN----DLDERGCTPLHYAATSDTDGKCLEYL 491
           + G +PL  A +  + +    L+ +GA +N    +  E   T   Y    +     + +L
Sbjct: 365 ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEM----VRFL 420

Query: 492 LRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATI 551
           L   A+   +  + + A+  +   GH    +L+            SG  +   +D+    
Sbjct: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD----------SGAQVNMPADSFE-- 468

Query: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611
           SPL LAA  GH +   +L++    L+  N  G TPL  AA +GH E V +L+ QGA+I  
Sbjct: 469 SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA 528

Query: 612 KDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYS 671
           +    + T +  A   G  E    LI     +   DI+ G   TPLM +   GH + V  
Sbjct: 529 QTEETQETALTLACCGGFLEVADFLI-----KAGADIELGCS-TPLMEAAQEGHLELVKY 582

Query: 672 LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGH 731
           LL  GANV A    G TAL      GH +  D LLQ GA        GRTP+  +A  GH
Sbjct: 583 LLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH 642

Query: 732 IGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLL 776
           +  +  L+   A+++    T  N+ +T L  AC  GH   VELLL
Sbjct: 643 VCTVQFLISKGANVN---RTTANNDHTVLSLACAGGHLAVVELLL 684



 Score =  147 bits (370), Expect = 7e-35
 Identities = 112/351 (31%), Positives = 174/351 (49%), Gaps = 7/351 (1%)

Query: 12  LVQAIFNGDPDEVRALIFKKEDVNFQDNE-KRTPLHAAAYLGDAEIIELLILSGARVNAK 70
           L++A   G  +  R L+     +N   NE K + L  A Y G  E++  L+ +GA    K
Sbjct: 371 LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHK 430

Query: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
             +  T L  A      E  ++LL   A VN    ++++PL +AA    V+ A  L+   
Sbjct: 431 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 490

Query: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINA-FDKKDRRAIHWAAYMGHIEVV 189
           +++   +  G T L  AA  GH EMV LLL +GANINA  ++    A+  A   G +EV 
Sbjct: 491 ASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVA 550

Query: 190 KLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYN 249
             L+  GA++   +    TPL  AA  G + +VKYLL  G +++   A G+T L  AC N
Sbjct: 551 DFLIKAGADI---ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACEN 607

Query: 250 GQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVN-MKSKDGKT 308
           G   V + L+  GA +  ++E G TPL  AA + H    ++ L+  GA+VN   + +  T
Sbjct: 608 GHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH-VCTVQFLISKGANVNRTTANNDHT 666

Query: 309 PLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLI 359
            L +    G  +  + ++  GA      K+G+T L  AA+ GH  ++  L+
Sbjct: 667 VLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717



 Score =  145 bits (366), Expect = 2e-34
 Identities = 116/373 (31%), Positives = 179/373 (47%), Gaps = 43/373 (11%)

Query: 28   IFKKEDVNFQ-DNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCS 86
            I+   D++ Q ++   T L  A   G  E+++ L+  GA +  +D K  TPL  A  +  
Sbjct: 1069 IYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGH 1128

Query: 87   EEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHH 146
               V++LL + AD+ A+                                S+R   T L  
Sbjct: 1129 VGVVEILLDNGADIEAQ--------------------------------SERTKDTPLSL 1156

Query: 147  AAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK--DK 204
            A   G  E+V+LLL+RGAN    +  D   +  AA  G++ ++K+L++ GAE+  +   K
Sbjct: 1157 ACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSK 1216

Query: 205  KSYTPLHAAASSGMISVVKYLLDLGVDMN-EPNAYGNTPLHVACYNGQDVVVNELIDCGA 263
               +PL  AA +G  + VK LLD+G D+N +     NT L +AC+ G+  VV+ L+D  A
Sbjct: 1217 LGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKA 1276

Query: 264  IVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNM----KSKDGKTPLHMTALHGRF 319
             V  + + G TPL  AA+  +  +   +L+  GADVN      S+D  T L + A  G +
Sbjct: 1277 NVEHRAKTGLTPLMEAASGGYAEVG-RVLLDKGADVNAPPVPSSRD--TALTIAADKGHY 1333

Query: 320  SRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLA 379
               + +I  GA ID  +K GNTPL +AA  GH  ++  L+ +GAD        + PL  A
Sbjct: 1334 KFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAA 1393

Query: 380  ALSGFSDCCRKLL 392
               G     R L+
Sbjct: 1394 FRKGHVKVVRYLV 1406



 Score =  144 bits (363), Expect = 4e-34
 Identities = 135/462 (29%), Positives = 201/462 (43%), Gaps = 54/462 (11%)

Query: 542 LSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDV 601
           + D   +  I+PL  AA  GH + +++L+    D++ ++S+G T L  A   G+V+ V V
Sbjct: 293 VEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKV 352

Query: 602 LINQGASILVKDYILK-RTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLS 660
           L+  GASI  +D+     TP+  A + GH E  RLL+ N    N    +    ++ L L+
Sbjct: 353 LLESGASI--EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFK--ESALTLA 408

Query: 661 VLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR 720
              GH + V  LL  GA+ + K     TAL    + GH E    LL  GA+  +      
Sbjct: 409 CYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 468

Query: 721 TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQ-- 778
           +P+ L+A  GH+ +   L++  AS++      ++ GYT L  A   GHE  V LLL Q  
Sbjct: 469 SPLTLAACGGHVELAALLIERGASLEE----VNDEGYTPLMEAAREGHEEMVALLLGQGA 524

Query: 779 EVFQKTEGNAFSPLHCAVINDNEGAAEMLIDT-----LGASI------------------ 815
            +  +TE    + L  A        A+ LI       LG S                   
Sbjct: 525 NINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLL 584

Query: 816 -----VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTN 870
                V+AT + G T L  A    H +   +LL   A +      G+TPLM AA  G   
Sbjct: 585 AAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVC 644

Query: 871 TVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPL 930
           TV+ L+S  +       N+ +T L LAC+ GH     L+L    D             P 
Sbjct: 645 TVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGAD-------------PT 691

Query: 931 HVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDV 972
           H   ++G TM+++   G   SV+    + Y   L  AP  DV
Sbjct: 692 H-RLKDGSTMLIEAAKGGHTSVVCYLLD-YPNNLLSAPPPDV 731



 Score =  144 bits (363), Expect = 4e-34
 Identities = 128/425 (30%), Positives = 195/425 (45%), Gaps = 13/425 (3%)

Query: 8   DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
           D   L+ A   G    V+ L+  K DVN Q +   T L  A   G  +++++L+ SGA +
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360

Query: 68  NAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNW-QTPLHIAAANKAVKCAEAL 126
              +    TPL  A ++   E  ++LL++ A +N     + ++ L +A     ++    L
Sbjct: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420

Query: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHI 186
           +   ++         TAL  A   GH E+ +LLL  GA +N         +  AA  GH+
Sbjct: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480

Query: 187 EVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN-EPNAYGNTPLHV 245
           E+  LL+  GA +   + + YTPL  AA  G   +V  LL  G ++N +      T L +
Sbjct: 481 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540

Query: 246 ACYNGQDVVVNELIDCGAIVNQKNEKG-FTPLHFAAASTHGALCLELLVGNGADVNMKSK 304
           AC  G   V + LI  GA +    E G  TPL  AA   H  L ++ L+  GA+V+  + 
Sbjct: 541 ACCGGFLEVADFLIKAGADI----ELGCSTPLMEAAQEGHLEL-VKYLLAAGANVHATTA 595

Query: 305 DGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD 364
            G T L     +G    +  ++Q+GA ++ E + G TPL  AAR GH   +  LI+ GA+
Sbjct: 596 TGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGAN 655

Query: 365 ---TAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECL 421
              T     H +  L LA   G       LL+ G D       G T L  AA GG+   +
Sbjct: 656 VNRTTANNDHTV--LSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVV 713

Query: 422 NLLLN 426
             LL+
Sbjct: 714 CYLLD 718



 Score =  137 bits (344), Expect = 7e-32
 Identities = 143/526 (27%), Positives = 232/526 (44%), Gaps = 64/526 (12%)

Query: 92   VLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDR----AGRTALHHA 147
            VLLK      A    +  P+   A  +A+  A   +P  S  N+++      G+  L  A
Sbjct: 935  VLLKDEPQQTAAQMGF-APIQPLAMPQALPLAAGPLPPGSIANLTELQGVIVGQPVLGQA 993

Query: 148  AFSGHGEMVKLLLSRGANIN--AFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKK 205
              +G G+ +     +G  +   A    D      AA  G    +    +H    +    +
Sbjct: 994  QLAGLGQGILTETQQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQ 1053

Query: 206  SYTPLHAAASSGMISVVKYL-LDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAI 264
            + TP    + S M+ +   + +D   + N      +T L +AC  G + +V  L++ GA 
Sbjct: 1054 TPTPSPIISPSAMLPIYPAIDIDAQTESNH-----DTALTLACAGGHEELVQTLLERGAS 1108

Query: 265  VNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGK-TPLHMTALHGRFSRSQ 323
            +  +++KGFTPL  AA + H  + +E+L+ NGAD+  +S+  K TPL +    GR    +
Sbjct: 1109 IEHRDKKGFTPLILAATAGHVGV-VEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVE 1167

Query: 324  TIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKR--GIHGMFPLHLAAL 381
             ++  GA  +  + +  TPL +AA  G+  +I  L+ +GA+   R     G+ PL LAA+
Sbjct: 1168 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1227

Query: 382  SGFSDCCRKLLSSGFDIDTPDDFGR-TCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRS 440
            +G +   + LL  G DI+   +  R T L  A   G  E ++LLL+  A+   + K G +
Sbjct: 1228 NGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLT 1287

Query: 441  PLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGI 500
            PL  AA+    +    L+  GA VN        P+                      P  
Sbjct: 1288 PLMEAASGGYAEVGRVLLDKGADVN------APPV----------------------PSS 1319

Query: 501  RDKQGYNAVHYSAAYGH-RLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAY 559
            RD     A+  +A  GH + C  LI     +DV              N+   +PL LAA 
Sbjct: 1320 RD----TALTIAADKGHYKFCELLIGRGAHIDV-------------RNKKGNTPLWLAAN 1362

Query: 560  HGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQ 605
             GH   +++LVQ+  D+D  ++   TPL  A  KGHV+ V  L+ +
Sbjct: 1363 GGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408



 Score =  135 bits (339), Expect = 3e-31
 Identities = 104/306 (33%), Positives = 157/306 (51%), Gaps = 7/306 (2%)

Query: 11   SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
            +L  A   G  + V+ L+ +   +  +D +  TPL  AA  G   ++E+L+ +GA + A+
Sbjct: 1086 ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 1145

Query: 71   DSKWL-TPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPL 129
              +   TPL  A +   +E V++LL   A+   R+ +  TPL +AA+   V   + L+  
Sbjct: 1146 SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1205

Query: 130  LSNVN--VSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR-AIHWAAYMGHI 186
             + +N     + G + L  AA +GH   VKLLL  G++INA  + +R  A+  A + G  
Sbjct: 1206 GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1265

Query: 187  EVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEP--NAYGNTPLH 244
            EVV LL+   A V  + K   TPL  AAS G   V + LLD G D+N P   +  +T L 
Sbjct: 1266 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1325

Query: 245  VACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSK 304
            +A   G       LI  GA ++ +N+KG TPL  AA   H  + ++LLV  GADV+    
Sbjct: 1326 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDV-VQLLVQAGADVDAADN 1384

Query: 305  DGKTPL 310
               TPL
Sbjct: 1385 RKITPL 1390



 Score =  129 bits (324), Expect = 1e-29
 Identities = 106/329 (32%), Positives = 155/329 (47%), Gaps = 16/329 (4%)

Query: 645  AVDIQ---DGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEEC 701
            A+DI    + N  T L L+   GH + V +LL +GA+++ +DK G T L   A  GH   
Sbjct: 1072 AIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGV 1131

Query: 702  VDALLQHGAKCLLRDSRGR-TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTAL 760
            V+ LL +GA    +  R + TP+ L+ + G   V+  LL    +  AN    +   YT L
Sbjct: 1132 VEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLL----ARGANKEHRNVSDYTPL 1187

Query: 761  HWACYNGHETCVELLLE--QEVFQKTEGN-AFSPLHCAVINDNEGAAEMLIDTLGASIVN 817
              A   G+   +++LL    E+  +T      SPL  A +N +  A ++L+D +G+ I  
Sbjct: 1188 SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLD-MGSDINA 1246

Query: 818  ATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLV- 876
              ++   T L  A F    E + LLL   A V     TG TPLM AA  G      +L+ 
Sbjct: 1247 QIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLD 1306

Query: 877  SSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARN 936
              A        +S++TAL +A  KGH     L++ +      I+  N    TPL +AA  
Sbjct: 1307 KGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAH---IDVRNKKGNTPLWLAANG 1363

Query: 937  GLTMVVQELLGKGASVLAVDENGYTPALA 965
            G   VVQ L+  GA V A D    TP +A
Sbjct: 1364 GHLDVVQLLVQAGADVDAADNRKITPLMA 1392



 Score =  120 bits (302), Expect = 5e-27
 Identities = 109/337 (32%), Positives = 157/337 (46%), Gaps = 19/337 (5%)

Query: 574  LDLDVRNSSGR-TPLDLAAFKGHVECVDVLINQGASILVKDYILKR--TPIHAAATNGHS 630
            +D+D +  S   T L LA   GH E V  L+ +GASI  +D   K+  TP+  AAT GH 
Sbjct: 1073 IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRD---KKGFTPLILAATAGHV 1129

Query: 631  ECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTAL 690
              + +L+ N     A    +    TPL L+   G  + V  LL +GAN + ++    T L
Sbjct: 1130 GVVEILLDNGADIEAQS--ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL 1187

Query: 691  HRGAVTGHEECVDALLQHGAKCLLRDSR--GRTPIHLSAACGHIGVLGALLQSAASMDAN 748
               A  G+   +  LL  GA+   R     G +P+ L+A  GH   +  LL   + ++A 
Sbjct: 1188 SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQ 1247

Query: 749  PATADNHGYTALHWACYNGHETCVELLLEQEV-FQKTEGNAFSPLHCAVINDNEGAAEML 807
              T  N   TAL  AC+ G    V LLL+++   +       +PL  A          +L
Sbjct: 1248 IETNRN---TALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1304

Query: 808  IDTLGASIVNA--TDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAE 865
            +D  GA  VNA    S   T L  AA   H +  +LL+   A ++  +  G TPL +AA 
Sbjct: 1305 LDK-GAD-VNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAAN 1362

Query: 866  NGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGH 902
             G  + V++LV  A A++   DN K T L  A  KGH
Sbjct: 1363 GGHLDVVQLLVQ-AGADVDAADNRKITPLMAAFRKGH 1398



 Score =  120 bits (300), Expect = 9e-27
 Identities = 106/360 (29%), Positives = 155/360 (43%), Gaps = 69/360 (19%)

Query: 554  LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 613
            L LA   GH + ++ L++    ++ R+  G TPL LAA  GHV  V++L++ GA I  + 
Sbjct: 1087 LTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQS 1146

Query: 614  YILKRTPIHAAATNGHSECLRLLI---GNAEPQNAVDI---------------------- 648
               K TP+  A + G  E + LL+    N E +N  D                       
Sbjct: 1147 ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 1206

Query: 649  -----QDGN--GQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGR-TALHRGAVTGHEE 700
                 + G+  G +PLML+ +NGHT  V  LL+ G++++A+ +  R TAL      G  E
Sbjct: 1207 AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTE 1266

Query: 701  CVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTAL 760
             V  LL   A    R   G TP+  +A+ G+  V   LL   A ++A P  +     TAL
Sbjct: 1267 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD--TAL 1324

Query: 761  HWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATD 820
              A   GH    ELL+ +                                 GA I +  +
Sbjct: 1325 TIAADKGHYKFCELLIGR---------------------------------GAHI-DVRN 1350

Query: 821  SKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSAS 880
             KG TPL  AA   H++ +QLL+   A V++ D+   TPLM A   G    V  LV   +
Sbjct: 1351 KKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVN 1410



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 74/224 (33%), Positives = 113/224 (50%), Gaps = 5/224 (2%)

Query: 8    DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKR--TPLHAAAYLGDAEIIELLILSGA 65
            D   L  A   G  + ++ L+    ++N +   K   +PL  AA  G    ++LL+  G+
Sbjct: 1183 DYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGS 1242

Query: 66   RVNAK-DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAE 124
             +NA+ ++   T L  A      E V +LL   A+V  R K   TPL  AA+    +   
Sbjct: 1243 DINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1302

Query: 125  ALVPLLSNVNVSD--RAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAY 182
             L+   ++VN      +  TAL  AA  GH +  +LL+ RGA+I+  +KK    +  AA 
Sbjct: 1303 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAAN 1362

Query: 183  MGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLL 226
             GH++VV+LLV  GA+V   D +  TPL AA   G + VV+YL+
Sbjct: 1363 GGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 88/311 (28%), Positives = 126/311 (40%), Gaps = 78/311 (25%)

Query: 726 SAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCV-ELLLE-QEVFQK 783
           S +C       AL +  A   AN   +DN    +L  AC  G    V +LL+E + V + 
Sbjct: 207 SVSCALDEAAAALTRMRAESTANAGQSDNR---SLAEACSEGDVNAVRKLLIEGRSVNEH 263

Query: 784 TE-GNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDS--KGR-TPLHAAAFTDHVECL 839
           TE G +   L C+      G  E L   L A   N  D   KG  TPL AAA   HV+ +
Sbjct: 264 TEEGESLLCLACSA-----GYYE-LAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIV 317

Query: 840 QLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSAS------------------- 880
           +LLL+H A VN+  STG T L  A   G  + V++L+ S +                   
Sbjct: 318 KLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSA 377

Query: 881 -----AELTLQDNS---------KNTALHLACSKGHETSALLILEKITDRN--------- 917
                A L L++ +         K +AL LAC KGH      +LE   D+          
Sbjct: 378 GHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTA 437

Query: 918 ---------------------LINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVD 956
                                 +N    + ++PL +AA  G   +   L+ +GAS+  V+
Sbjct: 438 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVN 497

Query: 957 ENGYTPALACA 967
           + GYTP +  A
Sbjct: 498 DEGYTPLMEAA 508



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 48/157 (30%), Positives = 75/157 (47%), Gaps = 5/157 (3%)

Query: 819  TDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSS 878
            T+S   T L  A    H E +Q LL   A +   D  G TPL++AA  G    VE+L+ +
Sbjct: 1079 TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 1138

Query: 879  ASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGL 938
             +      + +K+T L LACS G +    L+L +  ++   N ++    TPL +AA  G 
Sbjct: 1139 GADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSD---YTPLSLAASGGY 1195

Query: 939  TMVVQELLGKGASV--LAVDENGYTPALACAPNKDVA 973
              +++ LL  GA +      + G +P +  A N   A
Sbjct: 1196 VNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTA 1232



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 32/122 (26%), Positives = 60/122 (49%), Gaps = 3/122 (2%)

Query: 27   LIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCS 86
            LI +   ++ ++ +  TPL  AA  G  ++++LL+ +GA V+A D++ +TPL  A     
Sbjct: 1339 LIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGH 1398

Query: 87   EEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHH 146
             + V+ L+K   +VN    + +   +IA         +  + + S V   DR    A  +
Sbjct: 1399 VKVVRYLVK---EVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKN 1455

Query: 147  AA 148
            A+
Sbjct: 1456 AS 1457



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 43/166 (25%), Positives = 72/166 (43%), Gaps = 1/166 (0%)

Query: 2   AFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLI 61
           A ++L     L++A   G  + V+ L+    +V+       T L  A   G  ++ ++L+
Sbjct: 558 ADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLL 617

Query: 62  LSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVN-ARDKNWQTPLHIAAANKAV 120
            +GA +  +     TPL +A  +     VQ L+   A+VN     N  T L +A A   +
Sbjct: 618 QAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHL 677

Query: 121 KCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANI 166
              E L+   ++     + G T L  AA  GH  +V  LL    N+
Sbjct: 678 AVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNL 723


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.132    0.388 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,420,187
Number of Sequences: 37866
Number of extensions: 1776440
Number of successful extensions: 23118
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 372
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 3186
Number of HSP's gapped (non-prelim): 6471
length of query: 1053
length of database: 18,247,518
effective HSP length: 113
effective length of query: 940
effective length of database: 13,968,660
effective search space: 13130540400
effective search space used: 13130540400
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.