Guide to the Human Genome
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Search of human proteins with 62868215

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|62868215 laminin, beta 3 precursor [Homo sapiens]
         (1172 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|62868217 laminin, beta 3 precursor [Homo sapiens]                 2418   0.0  
gi|62868215 laminin, beta 3 precursor [Homo sapiens]                 2418   0.0  
gi|189083719 laminin, beta 3 precursor [Homo sapiens]                2418   0.0  
gi|119703755 laminin, beta 2 precursor [Homo sapiens]                 468   e-131
gi|143770880 laminin, beta 4 [Homo sapiens]                           447   e-125
gi|167614504 laminin, beta 1 precursor [Homo sapiens]                 424   e-118
gi|21264602 laminin alpha 5 [Homo sapiens]                            323   5e-88
gi|93204871 netrin 4 [Homo sapiens]                                   305   1e-82
gi|219842266 usherin isoform B [Homo sapiens]                         298   3e-80
gi|219842259 usherin isoform A [Homo sapiens]                         298   3e-80
gi|145309326 laminin, gamma 1 precursor [Homo sapiens]                276   6e-74
gi|38045910 laminin alpha 3 subunit isoform 1 [Homo sapiens]          269   1e-71
gi|189217425 laminin alpha 3 subunit isoform 3 [Homo sapiens]         269   1e-71
gi|110611156 laminin, gamma 3 precursor [Homo sapiens]                253   6e-67
gi|148613884 netrin 1 [Homo sapiens]                                  223   6e-58
gi|38788416 laminin, alpha 1 precursor [Homo sapiens]                 213   1e-54
gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo s...   200   6e-51
gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo sa...   200   6e-51
gi|5453810 netrin 3 [Homo sapiens]                                    196   1e-49
gi|164414431 netrin G1 isoform 1 [Homo sapiens]                       162   2e-39
gi|24308065 netrin 5 [Homo sapiens]                                   156   1e-37
gi|190014607 netrin G2 [Homo sapiens]                                 152   2e-36
gi|157419138 laminin, gamma 2 isoform a precursor [Homo sapiens]      138   4e-32
gi|157419140 laminin, gamma 2 isoform b precursor [Homo sapiens]      135   2e-31
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]            120   6e-27
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]               116   1e-25
gi|122937440 multiple EGF-like-domains 9 [Homo sapiens]               114   5e-25
gi|24586659 scavenger receptor class F, member 2 isoform 1 [Homo...   112   2e-24
gi|33598937 scavenger receptor class F, member 2 isoform 2 [Homo...   112   2e-24
gi|122937343 platelet endothelial aggregation receptor 1 [Homo s...   109   2e-23

>gi|62868217 laminin, beta 3 precursor [Homo sapiens]
          Length = 1172

 Score = 2418 bits (6266), Expect = 0.0
 Identities = 1172/1172 (100%), Positives = 1172/1172 (100%)

Query: 1    MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG 60
            MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG
Sbjct: 1    MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG 60

Query: 61   EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM 120
            EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM
Sbjct: 61   EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM 120

Query: 121  MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP 180
            MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP
Sbjct: 121  MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP 180

Query: 181  NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA 240
            NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA
Sbjct: 181  NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA 240

Query: 241  VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR 300
            VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR
Sbjct: 241  VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR 300

Query: 301  PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL 360
            PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL
Sbjct: 301  PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL 360

Query: 361  HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL 420
            HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL
Sbjct: 361  HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL 420

Query: 421  TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP 480
            TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP
Sbjct: 421  TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP 480

Query: 481  CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG 540
            CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG
Sbjct: 481  CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG 540

Query: 541  TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG 600
            TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG
Sbjct: 541  TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG 600

Query: 601  RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR 660
            RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR
Sbjct: 601  RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR 660

Query: 661  TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST 720
            TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST
Sbjct: 661  TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST 720

Query: 721  AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL 780
            AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL
Sbjct: 721  AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL 780

Query: 781  TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR 840
            TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR
Sbjct: 781  TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR 840

Query: 841  GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT 900
            GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT
Sbjct: 841  GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT 900

Query: 901  DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR 960
            DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR
Sbjct: 901  DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR 960

Query: 961  RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ 1020
            RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ
Sbjct: 961  RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ 1020

Query: 1021 VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER 1080
            VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER
Sbjct: 1021 VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER 1080

Query: 1081 IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI 1140
            IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI
Sbjct: 1081 IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI 1140

Query: 1141 MLRSADLTGLEKRVEQIRDHINGRVLYYATCK 1172
            MLRSADLTGLEKRVEQIRDHINGRVLYYATCK
Sbjct: 1141 MLRSADLTGLEKRVEQIRDHINGRVLYYATCK 1172


>gi|62868215 laminin, beta 3 precursor [Homo sapiens]
          Length = 1172

 Score = 2418 bits (6266), Expect = 0.0
 Identities = 1172/1172 (100%), Positives = 1172/1172 (100%)

Query: 1    MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG 60
            MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG
Sbjct: 1    MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG 60

Query: 61   EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM 120
            EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM
Sbjct: 61   EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM 120

Query: 121  MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP 180
            MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP
Sbjct: 121  MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP 180

Query: 181  NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA 240
            NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA
Sbjct: 181  NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA 240

Query: 241  VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR 300
            VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR
Sbjct: 241  VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR 300

Query: 301  PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL 360
            PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL
Sbjct: 301  PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL 360

Query: 361  HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL 420
            HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL
Sbjct: 361  HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL 420

Query: 421  TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP 480
            TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP
Sbjct: 421  TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP 480

Query: 481  CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG 540
            CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG
Sbjct: 481  CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG 540

Query: 541  TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG 600
            TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG
Sbjct: 541  TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG 600

Query: 601  RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR 660
            RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR
Sbjct: 601  RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR 660

Query: 661  TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST 720
            TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST
Sbjct: 661  TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST 720

Query: 721  AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL 780
            AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL
Sbjct: 721  AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL 780

Query: 781  TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR 840
            TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR
Sbjct: 781  TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR 840

Query: 841  GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT 900
            GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT
Sbjct: 841  GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT 900

Query: 901  DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR 960
            DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR
Sbjct: 901  DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR 960

Query: 961  RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ 1020
            RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ
Sbjct: 961  RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ 1020

Query: 1021 VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER 1080
            VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER
Sbjct: 1021 VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER 1080

Query: 1081 IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI 1140
            IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI
Sbjct: 1081 IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI 1140

Query: 1141 MLRSADLTGLEKRVEQIRDHINGRVLYYATCK 1172
            MLRSADLTGLEKRVEQIRDHINGRVLYYATCK
Sbjct: 1141 MLRSADLTGLEKRVEQIRDHINGRVLYYATCK 1172


>gi|189083719 laminin, beta 3 precursor [Homo sapiens]
          Length = 1172

 Score = 2418 bits (6266), Expect = 0.0
 Identities = 1172/1172 (100%), Positives = 1172/1172 (100%)

Query: 1    MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG 60
            MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG
Sbjct: 1    MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG 60

Query: 61   EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM 120
            EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM
Sbjct: 61   EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM 120

Query: 121  MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP 180
            MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP
Sbjct: 121  MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP 180

Query: 181  NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA 240
            NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA
Sbjct: 181  NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA 240

Query: 241  VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR 300
            VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR
Sbjct: 241  VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR 300

Query: 301  PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL 360
            PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL
Sbjct: 301  PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL 360

Query: 361  HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL 420
            HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL
Sbjct: 361  HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL 420

Query: 421  TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP 480
            TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP
Sbjct: 421  TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP 480

Query: 481  CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG 540
            CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG
Sbjct: 481  CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG 540

Query: 541  TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG 600
            TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG
Sbjct: 541  TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG 600

Query: 601  RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR 660
            RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR
Sbjct: 601  RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR 660

Query: 661  TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST 720
            TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST
Sbjct: 661  TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST 720

Query: 721  AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL 780
            AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL
Sbjct: 721  AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL 780

Query: 781  TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR 840
            TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR
Sbjct: 781  TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR 840

Query: 841  GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT 900
            GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT
Sbjct: 841  GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT 900

Query: 901  DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR 960
            DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR
Sbjct: 901  DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR 960

Query: 961  RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ 1020
            RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ
Sbjct: 961  RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ 1020

Query: 1021 VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER 1080
            VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER
Sbjct: 1021 VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER 1080

Query: 1081 IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI 1140
            IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI
Sbjct: 1081 IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI 1140

Query: 1141 MLRSADLTGLEKRVEQIRDHINGRVLYYATCK 1172
            MLRSADLTGLEKRVEQIRDHINGRVLYYATCK
Sbjct: 1141 MLRSADLTGLEKRVEQIRDHINGRVLYYATCK 1172


>gi|119703755 laminin, beta 2 precursor [Homo sapiens]
          Length = 1798

 Score =  468 bits (1204), Expect = e-131
 Identities = 231/514 (44%), Positives = 304/514 (59%), Gaps = 26/514 (5%)

Query: 21  CSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYC-TQYGEWQMKCCKCDSRQPH---- 75
           CSRG+CYP  GDLLVGR   L ASSTCGL  P+ YC   + + + KC  CDSR+P     
Sbjct: 42  CSRGSCYPATGDLLVGRADRLTASSTCGLNGPQPYCIVSHLQDEKKCFLCDSRRPFSARD 101

Query: 76  NYYSHRVENVASSSGPMR---WWQSQNDVNPVSLQLDLDRRFQLQEVMMEFQGPMPAGML 132
           N +SHR++NV +S  P R   WWQS+N +  V++QLDL+  F    ++M F+   PA ML
Sbjct: 102 NPHSHRIQNVVTSFAPQRRAAWWQSENGIPAVTIQLDLEAEFHFTHLIMTFKTFRPAAML 161

Query: 133 IERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRPNARLNGGKVQLN 192
           +ERS+DFG+TW VY+Y + DC + FP V    P+ W DV C+S          G +V   
Sbjct: 162 VERSADFGRTWHVYRYFSYDCGADFPGVPLAPPRHWDDVVCESRYSEIEPSTEG-EVIYR 220

Query: 193 LMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHP-----PSAYYAVSQLRLQ 247
           ++D    IP   S +IQ + +ITNLRVN TRL  +      P        YYA+ +L ++
Sbjct: 221 VLDPAIPIPDPYSSRIQNLLKITNLRVNLTRLHTLGDNLLDPRREIREKYYYALYELVVR 280

Query: 248 GSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEG 307
           G+CFC+GHA  CAP PGA A       VH  C+C+HNT G NCE+C  FY + PWRPAE 
Sbjct: 281 GNCFCYGHASECAPAPGAPAHAEG--MVHGACICKHNTRGLNCEQCQDFYRDLPWRPAED 338

Query: 308 QDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRR 367
             +H C++C+C+GH+ +CHFD AV+ AS    GGVCD C+ +T G++CE C+  ++R+  
Sbjct: 339 GHSHACRKCECHGHTHSCHFDMAVYLASGNVSGGVCDGCQHNTAGRHCELCRPFFYRDPT 398

Query: 368 PGASIQETCISCECDPDGAVPGAPCDP--------VTGQCVCKEHVQGERCDLCKPGFTG 419
                   C SC+CDP G+  G  CD         V+GQC CKEHV G RC  C+ GF G
Sbjct: 399 KDLRDPAVCRSCDCDPMGSQDGGRCDSHDDPALGLVSGQCRCKEHVVGTRCQQCRDGFFG 458

Query: 420 LTYANPQGCHRCDCNILGS-RRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASG-QG 477
           L+ ++  GC RC CN  G+     PCD  SG C C   V G  CD+C P HW L+    G
Sbjct: 459 LSISDRLGCRRCQCNARGTVPGSTPCDPNSGSCYCKRLVTGRGCDRCLPGHWGLSHDLLG 518

Query: 478 CEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMC 511
           C PC CD   +L PQC++ TGQC CR+   G  C
Sbjct: 519 CRPCDCDVGGALDPQCDEGTGQCHCRQHMVGRRC 552



 Score =  416 bits (1070), Expect = e-116
 Identities = 300/978 (30%), Positives = 448/978 (45%), Gaps = 111/978 (11%)

Query: 250  CFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQD 309
            C C+GHAD C    GA  G            C+ +T G +CERC   ++  P  P  GQ 
Sbjct: 877  CVCNGHADECNTHTGACLG------------CRDHTGGEHCERCIAGFHGDPRLPYGGQ- 923

Query: 310  AHECQRCDC-NGHSETCHFDPAVFAASQGAYGG--VCDNCRDHTEGKNCERCQLHYFRN- 365
               C+ C C  G     HF     +  Q  Y    VC +CR    G  CE C   +F + 
Sbjct: 924  ---CRPCPCPEGPGSQRHF---ATSCHQDEYSQQIVC-HCRAGYTGLRCEACAPGHFGDP 976

Query: 366  RRPGASIQETCISCEC-------DPDGAVPGAPCDPVTGQCV-CKEHVQGERCDLCKPGF 417
             RPG      C  CEC       DPD       CDP TGQC+ C  H +G  C  CKPGF
Sbjct: 977  SRPGGR----CQLCECSGNIDPMDPDA------CDPHTGQCLRCLHHTEGPHCAHCKPGF 1026

Query: 418  TGLTYANPQGCHRCDCNILGSRRDM-------PCDEESGRCLCLPNVVGPKCDQCAPYHW 470
             G   A  Q CHRC CN+LG+            CD  SG+C CLPNV GP CD+CAP  W
Sbjct: 1027 HG--QAARQSCHRCTCNLLGTNPQQCPSPDQCHCDPSSGQCPCLPNVQGPSCDRCAPNFW 1084

Query: 471  KLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATG 530
             L SG GC+PCAC P  +  P CN+FTGQC CR GFGG  CS     +C +  +GD    
Sbjct: 1085 NLTSGHGCQPCACHPSRARGPTCNEFTGQCHCRAGFGGRTCS-----ECQELHWGDPGLQ 1139

Query: 531  CRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDA 590
            C ACDCD RG + P C + +G C CRPG++G RCDQC RG+   +P C  CH CF  +D 
Sbjct: 1140 CHACDCDSRGIDTPQCHRFTGHCSCRPGVSGVRCDQCARGFSGIFPACHPCHACFGDWDR 1199

Query: 591  DLREQALRFGRLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQ 650
             +++ A R  RL      L     L      S     + K+  ++ ++ +   +    AQ
Sbjct: 1200 VVQDLAARTQRLEQRAQELQQTGVL--GAFESSFWHMQEKLGIVQGIVGARNTSAASTAQ 1257

Query: 651  VASAILSLRRT-------LQGLQLDL-PLEEETLSLPRDLESLDRSFNGLLTMYQRKREQ 702
            +  A   LRR        L  L+ DL  +++E  +    L  L+R    L    ++  + 
Sbjct: 1258 LVEATEELRREIGEATEHLTQLEADLTDVQDENFNANHALSGLERDRLALNLTLRQLDQH 1317

Query: 703  FEKISSADPSGAFRMLSTAYEQSAQAAQQVSDSSRLL--------------DQLRDSRRE 748
             + +  ++  GA+  +  A+ QSA+A ++ + S+  +              + L D+++E
Sbjct: 1318 LDLLKHSNFLGAYDSIRHAHSQSAEAERRANTSALAVPSPVSNSASARHRTEALMDAQKE 1377

Query: 749  ---AERLVRQAGGGGGTGSPKLVALRLEMSSLPDLTPTFNKLCGNSRQMACTPISCPGEL 805
               ++ +  Q   G      KL A    +S    LT     +CG      C    C G  
Sbjct: 1378 DFNSKHMANQRALG------KLSAHTHTLS----LTDINELVCGAPGDAPCATSPCGGAG 1427

Query: 806  CPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLRGFNAQLQRTRQ-----MIRAAE--E 858
            C  ++G     RC G+     GA   A     + R   A+LQR        + R AE   
Sbjct: 1428 CRDEDGQ---PRCGGL--SCNGAAATADLALGRARHTQAELQRALAEGGSILSRVAETRR 1482

Query: 859  SASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLTDPDTDAATIQEVSEAVLA 918
             AS+ Q  AQ    + +ASR Q+E+  +  + LIQ V+DFL     D  +I+ V+  VL 
Sbjct: 1483 QASEAQQRAQAALDKANASRGQVEQANQELQELIQSVKDFLNQEGADPDSIEMVATRVLE 1542

Query: 919  LWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARARRLQAEAEEARSRAHAVEG 978
            L +P  +  +      I      L +VD +L++T  D+ RA +L  +A  ARS A   + 
Sbjct: 1543 LSIPASAEQIQHLAGAIAERVRSLADVDAILARTVGDVRRAEQLLQDARRARSWAEDEKQ 1602

Query: 979  QVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQVLRPAEKLVTSMTKQLGD 1038
            + E V   L +   A   AQ  ++G     R  +  + +VQ+ +  AE+ ++S  ++   
Sbjct: 1603 KAETVQAALEEAQRAQGIAQGAIRGAVADTRDTEQTLYQVQERMAGAERALSSAGERARQ 1662

Query: 1039 FWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFE-RIKQKYAELK---DRLGQ 1094
                +E L+ +       A  A++ A  A  +A  A++     +  +Y  +K   +R  Q
Sbjct: 1663 LDALLEALKLKRAGNSLAASTAEETAGSAQGRAQEAEQLLRGPLGDQYQTVKALAERKAQ 1722

Query: 1095 SSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAIMLRSADLTGLEKRV 1154
              +  +  AR + ++ EA +L     + + R++++E       +A+  ++A L GLE R+
Sbjct: 1723 GVLAAQ--ARAEQLRDEARDLLQAAQDKLQRLQELEGTYEENERALESKAAQLDGLEARM 1780

Query: 1155 EQIRDHINGRVLYYATCK 1172
              +   IN +V  Y TC+
Sbjct: 1781 RSVLQAINLQVQIYNTCQ 1798



 Score =  144 bits (362), Expect = 6e-34
 Identities = 93/291 (31%), Positives = 126/291 (43%), Gaps = 49/291 (16%)

Query: 316 CDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHY----FRNRRPGAS 371
           C C GH+  C   P   A ++G   G C  C+ +T G NCE+CQ  Y    +R    G S
Sbjct: 283 CFCYGHASECAPAPGAPAHAEGMVHGACI-CKHNTRGLNCEQCQDFYRDLPWRPAEDGHS 341

Query: 372 IQETCISCECD--------------PDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGF 417
               C  CEC                 G V G  CD       C+ +  G  C+LC+P F
Sbjct: 342 --HACRKCECHGHTHSCHFDMAVYLASGNVSGGVCDG------CQHNTAGRHCELCRPFF 393

Query: 418 ---TGLTYANPQGCHRCDCNILGSRRDMPCDEE--------SGRCLCLPNVVGPKCDQCA 466
                    +P  C  CDC+ +GS+    CD          SG+C C  +VVG +C QC 
Sbjct: 394 YRDPTKDLRDPAVCRSCDCDPMGSQDGGRCDSHDDPALGLVSGQCRCKEHVVGTRCQQCR 453

Query: 467 PYHWKLASGQ--GCEPCACDPHNSL--SPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDR 522
              + L+     GC  C C+   ++  S  C+  +G C C+    G  C      +C   
Sbjct: 454 DGFFGLSISDRLGCRRCQCNARGTVPGSTPCDPNSGSCYCKRLVTGRGCD-----RCLPG 508

Query: 523 TYG--DVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGY 571
            +G      GCR CDCD  G   P CD+ +G+C CR  + G RC+Q Q GY
Sbjct: 509 HWGLSHDLLGCRPCDCDVGGALDPQCDEGTGQCHCRQHMVGRRCEQVQPGY 559



 Score =  133 bits (335), Expect = 9e-31
 Identities = 77/215 (35%), Positives = 101/215 (46%), Gaps = 33/215 (15%)

Query: 372 IQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRC 431
           I    + C+C+P G++  + C+P  GQC+CK  V G RCDLC PG+ G     P GC  C
Sbjct: 776 IYNGALPCQCNPQGSL-SSECNPHGGQCLCKPGVVGRRCDLCAPGYYGF---GPTGCQAC 831

Query: 432 DCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSP 491
            C+  G+   + C++ SG+CLC     G +CD+C    W   S   C PC C+ H   + 
Sbjct: 832 QCSHEGALSSL-CEKTSGQCLCRTGAFGLRCDRCQRGQWGFPS---CRPCVCNGH---AD 884

Query: 492 QCNQFTGQC-PCREGFGGLMCS--AAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDK 548
           +CN  TG C  CR+  GG  C    A     P   YG     CR C C     EGPG  +
Sbjct: 885 ECNTHTGACLGCRDHTGGEHCERCIAGFHGDPRLPYGG---QCRPCPC----PEGPGSQR 937

Query: 549 ASGR------------CLCRPGLTGPRCDQCQRGY 571
                           C CR G TG RC+ C  G+
Sbjct: 938 HFATSCHQDEYSQQIVCHCRAGYTGLRCEACAPGH 972



 Score =  103 bits (256), Expect = 1e-21
 Identities = 73/241 (30%), Positives = 98/241 (40%), Gaps = 45/241 (18%)

Query: 380 ECDPDGAVPGAPCDP---VTGQCVCKEHVQGERCDLCKPGFTGLTY-----ANPQGCHRC 431
           EC P    PGAP      V G C+CK + +G  C+ C+  +  L +      +   C +C
Sbjct: 291 ECAP---APGAPAHAEGMVHGACICKHNTRGLNCEQCQDFYRDLPWRPAEDGHSHACRKC 347

Query: 432 DCN--ILGSRRDMPCDEESGRCL------CLPNVVGPKCDQCAPYHWK-----LASGQGC 478
           +C+        DM     SG         C  N  G  C+ C P+ ++     L     C
Sbjct: 348 ECHGHTHSCHFDMAVYLASGNVSGGVCDGCQHNTAGRHCELCRPFFYRDPTKDLRDPAVC 407

Query: 479 EPCACDPHNSLS---------PQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYG---D 526
             C CDP  S           P     +GQC C+E   G  C     +QC D  +G    
Sbjct: 408 RSCDCDPMGSQDGGRCDSHDDPALGLVSGQCRCKEHVVGTRC-----QQCRDGFFGLSIS 462

Query: 527 VATGCRACDCDFRGTEGPG---CDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHP 583
              GCR C C+ RGT  PG   CD  SG C C+  +TG  CD+C  G+       + C P
Sbjct: 463 DRLGCRRCQCNARGTV-PGSTPCDPNSGSCYCKRLVTGRGCDRCLPGHWGLSHDLLGCRP 521

Query: 584 C 584
           C
Sbjct: 522 C 522



 Score =  102 bits (254), Expect = 2e-21
 Identities = 59/150 (39%), Positives = 73/150 (48%), Gaps = 16/150 (10%)

Query: 444 CDEESGRCLCLPNVVGPKCDQCAPYHWKLAS--GQGCEPCACDPHNSLSPQCNQFTGQCP 501
           C EE      +P+   P  + CAP    L++    G  PC C+P  SLS +CN   GQC 
Sbjct: 749 CHEEG----LVPSKTSPS-EACAPLLISLSTLIYNGALPCQCNPQGSLSSECNPHGGQCL 803

Query: 502 CREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTG 561
           C+ G  G  C       C    YG   TGC+AC C   G     C+K SG+CLCR G  G
Sbjct: 804 CKPGVVGRRCDL-----CAPGYYGFGPTGCQACQCSHEGALSSLCEKTSGQCLCRTGAFG 858

Query: 562 PRCDQCQRGYCNRYPVCVACHPCFQTYDAD 591
            RCD+CQRG    +P   +C PC     AD
Sbjct: 859 LRCDRCQRGQWG-FP---SCRPCVCNGHAD 884


>gi|143770880 laminin, beta 4 [Homo sapiens]
          Length = 1761

 Score =  447 bits (1150), Expect = e-125
 Identities = 225/523 (43%), Positives = 306/523 (58%), Gaps = 25/523 (4%)

Query: 17  AQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCT-QYGEWQMKCCKCDSRQPH 75
           AQ  C+RGAC+P  GDLLVGR   L ASSTCGL++ + YC   Y E + KC  CDSR P+
Sbjct: 19  AQDDCNRGACHPTTGDLLVGRNTQLMASSTCGLSRAQKYCILSYLEGEQKCFICDSRFPY 78

Query: 76  NYY----SHRVENVASSSGPMR---WWQSQNDVNPVSLQLDLDRRFQLQEVMMEFQGPMP 128
           + Y    SH +ENV  S  P R   WWQS+N ++ VS++LDL+  F+   +++ F+   P
Sbjct: 79  DPYDQPNSHTIENVIVSFEPDREKKWWQSENGLDHVSIRLDLEALFRFSHLILTFKTFRP 138

Query: 129 AGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRPNARLNGGK 188
           A ML+ERS+D+G  W+V++Y A DC ++FP +  G+ Q   D+ C S          GG+
Sbjct: 139 AAMLVERSTDYGHNWKVFKYFAKDCATSFPNITSGQAQGVGDIVCDSKYSDIEPS-TGGE 197

Query: 189 VQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVP------QRGYHPPSAYYAVS 242
           V L ++D    I    S  IQ++  +TNLR+NFT+L  +       ++       YYA+ 
Sbjct: 198 VVLKVLDPSFEIENPYSPYIQDLVTLTNLRINFTKLHTLGDALLGRRQNDSLDKYYYALY 257

Query: 243 QLRLQGSCFCHGHADRCAPKPGASAGP-STAVQVHDVCVCQHNTAGPNCERCAPFYNNRP 301
           ++ ++GSCFC+GHA  C P         S    VH  CVCQHNT GPNCERC  F+ + P
Sbjct: 258 EMIVRGSCFCNGHASECRPMQKMRGDVFSPPGMVHGQCVCQHNTDGPNCERCKDFFQDAP 317

Query: 302 WRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLH 361
           WRPA     + C+ C CN HS  CHFD   + AS G  GGVC++C+ +TEG++C+RC+  
Sbjct: 318 WRPAADLQDNACRSCSCNSHSSRCHFDMTTYLASGGLSGGVCEDCQHNTEGQHCDRCRPL 377

Query: 362 YFRNRRPGASIQETCISCECDPDGAVPGAPC----DP----VTGQCVCKEHVQGERCDLC 413
           ++R+     S    CI CECDPDG + G  C    DP    V GQC+CKE+V+G +CD C
Sbjct: 378 FYRDPLKTISDPYACIPCECDPDGTISGGICVSHSDPALGSVAGQCLCKENVEGAKCDQC 437

Query: 414 KPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLA 473
           KP   GL+  +P GC  CDCN LGS   + CD ++G+CLCL  V G  C++C   +W L 
Sbjct: 438 KPNHYGLSATDPLGCQPCDCNPLGSLPFLTCDVDTGQCLCLSYVTGAHCEECTVGYWGLG 497

Query: 474 SG-QGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAA 515
           +   GC PC CD   + S  C+   GQC CR    G  CS  A
Sbjct: 498 NHLHGCSPCDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPA 540



 Score =  361 bits (927), Expect = 2e-99
 Identities = 259/996 (26%), Positives = 429/996 (43%), Gaps = 125/996 (12%)

Query: 253  HG-HADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAH 311
            HG H   C P+    +  +   QV   C C    +G  C+RC   Y   P          
Sbjct: 812  HGCHPCHCHPQ---GSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFP---------- 858

Query: 312  ECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGAS 371
             C  C CN  +E C  DP           G C NC   T G+NCERC   Y+ N   G  
Sbjct: 859  SCHPCPCNRFAELC--DPET---------GSCFNCGGFTTGRNCERCIDGYYGNPSSG-- 905

Query: 372  IQETCISCECDPDGA-------------------------------------------VP 388
              + C  C C  D +                                           + 
Sbjct: 906  --QPCRPCLCPDDPSSNQYFAHSCYQNLWSSDVICNCLQGYTGTQCGECSTGFYGNPRIS 963

Query: 389  GAPCDP-----------------VTGQCV-CKEHVQGERCDLCKPGFTGLTYANPQGCHR 430
            GAPC P                 VTG+C+ C  + QG  C LCKPG  G   A  Q C R
Sbjct: 964  GAPCQPCACNNNIDVTDPESCSRVTGECLRCLHNTQGANCQLCKPGHYGS--ALNQTCRR 1021

Query: 431  CDCNILG-SRRDMP-------CDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCA 482
            C C+  G S  + P       CD  +G C CLPNV G  CD+CA  +W L  G+GC+ C 
Sbjct: 1022 CSCHASGVSPMECPPGGGACLCDPVTGACPCLPNVTGLACDRCADGYWNLVPGRGCQSCD 1081

Query: 483  CDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTE 542
            CDP  S S  C+Q TGQCPC+ G+GG  CS     +C +  YGD    C  CDC+  GT+
Sbjct: 1082 CDPRTSQSSHCDQLTGQCPCKLGYGGKRCS-----ECQENYYGDPPGRCIPCDCNRAGTQ 1136

Query: 543  GPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFGRL 602
             P CD  +G C CR G++G RCD+C RG+   +P C+ CH CF  +D  +   +     L
Sbjct: 1137 KPICDPDTGMCRCREGVSGQRCDRCARGHSQEFPTCLQCHLCFDQWDHTISSLSKAVQGL 1196

Query: 603  RNATASLWSGPGLEDRGLASRILDA-----KSKIEQIRAVLSSPAVTEQEVAQVASAILS 657
                A+      +ED+     + +A     +  + +I  +L  P     +  +V     S
Sbjct: 1197 MRLAAN------MEDKRETLPVCEADFKDLRGNVSEIERILKHPVFPSGKFLKVKDYHDS 1250

Query: 658  LRRTLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRM 717
            +RR +  L   L    E   L   +E      + LL   Q + +    + +A  + +   
Sbjct: 1251 VRRQIMQLNEQLKAVYEFQDLKDTIERAKNEADLLLEDLQEEIDLQSSVLNASIADSSEN 1310

Query: 718  LSTAYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSL 777
            +   Y  S+ A ++++++S  ++   ++R +   ++        T    L   RL+   +
Sbjct: 1311 IKKYYHISSSAEKKINETSSTINTSANTRNDLLTILDTL-----TSKGNLSLERLKQIKI 1365

Query: 778  PDLTPTFNKLCGNSRQMACTPISCPGELCPQDNG--TACGSRCRGVLPRAGGAFLMAGQV 835
            PD+     K+CG+   + C P+ C G LC    G     G  C G L  +  A   A + 
Sbjct: 1366 PDIQILNEKVCGDPGNVPCVPLPCGGALCTGRKGHRKCRGPGCHGSLTLSTNALQKAQEA 1425

Query: 836  AEQLRGFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQV 895
               +R  + Q++  +  I +  E A   +++A +L  ++   R+Q + +     L I++V
Sbjct: 1426 KSIIRNLDKQVRGLKNQIESISEQAEVSKNNALQLREKLGNIRNQSDSEEENINLFIKKV 1485

Query: 896  RDFLTDPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQD 955
            ++FL + +     I++V+  VL + LP  S  +  ++ +IQ       +     ++  ++
Sbjct: 1486 KNFLLEENVPPEDIEKVANGVLDIHLPIPSQNLTDELVKIQKHMQLCEDYRTDENRLNEE 1545

Query: 956  IARARRLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRV 1015
               A++L  +A+ A   A+ +   ++  +  L+Q  +    A  T+   + ++  I+  V
Sbjct: 1546 ADGAQKLLVKAKAAEKAANILL-NLDKTLNQLQQAQITQGRANSTITQLTANITKIKKNV 1604

Query: 1016 AEVQQVLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQ 1075
             + +   R   K    + KQ       +  L+ + ++    AV A+  AE A  QA S +
Sbjct: 1605 LQAENQTREM-KSELELAKQRSGLEDGLSLLQTKLQRHQDHAVNAKVQAESAQHQAGSLE 1663

Query: 1076 EGFERIKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLR 1135
            + F  +K++YA L+ +   + +  E   +++ +K  AE+L G+T   + R+ D+E ++  
Sbjct: 1664 KEFVELKKQYAILQRKTSTTGLTKETLGKVKQLKDAAEKLAGDTEAKIRRITDLERKIQD 1723

Query: 1136 GSQAIMLRSADLTGLEKRVEQIRDHINGRVLYYATC 1171
             + +   ++  L  LE +V  I++ I  +   YA C
Sbjct: 1724 LNLSRQAKADQLRILEDQVVAIKNEIVEQEKKYARC 1759



 Score =  149 bits (375), Expect = 2e-35
 Identities = 96/291 (32%), Positives = 133/291 (45%), Gaps = 47/291 (16%)

Query: 316 CDCNGHSETCH----FDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNR--RPG 369
           C CNGH+  C         VF+   G   G C  C+ +T+G NCERC+  +F++   RP 
Sbjct: 265 CFCNGHASECRPMQKMRGDVFSPP-GMVHGQCV-CQHNTDGPNCERCK-DFFQDAPWRPA 321

Query: 370 ASIQET-CISCECDP--------------DGAVPGAPCDPVTGQCVCKEHVQGERCDLCK 414
           A +Q+  C SC C+                G + G  C+       C+ + +G+ CD C+
Sbjct: 322 ADLQDNACRSCSCNSHSSRCHFDMTTYLASGGLSGGVCED------CQHNTEGQHCDRCR 375

Query: 415 PGFTG---LTYANPQGCHRCDCN--------ILGSRRDMPCDEESGRCLCLPNVVGPKCD 463
           P F      T ++P  C  C+C+        I  S  D      +G+CLC  NV G KCD
Sbjct: 376 PLFYRDPLKTISDPYACIPCECDPDGTISGGICVSHSDPALGSVAGQCLCKENVEGAKCD 435

Query: 464 QCAPYHWKLASGQ--GCEPCACDPHNSLS-PQCNQFTGQCPCREGFGGLMCSAAAIRQCP 520
           QC P H+ L++    GC+PC C+P  SL    C+  TGQC C     G  C    +    
Sbjct: 436 QCKPNHYGLSATDPLGCQPCDCNPLGSLPFLTCDVDTGQCLCLSYVTGAHCEECTVGYWG 495

Query: 521 DRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGY 571
               G+   GC  CDCD  G     C   +G+C CRP +TG  C +   GY
Sbjct: 496 ---LGNHLHGCSPCDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGY 543



 Score =  114 bits (286), Expect = 4e-25
 Identities = 96/332 (28%), Positives = 117/332 (35%), Gaps = 97/332 (29%)

Query: 325  CHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPD 384
            CH   +V  +S    GG C  C+    G+ C+RC    +     G      C  C C P 
Sbjct: 771  CHPQGSV-GSSCSRLGGQCQ-CKPLVVGRCCDRCSTGSYDLGHHG------CHPCHCHPQ 822

Query: 385  GAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPC 444
            G+     CD VTGQC C   V G RCD C  G+ G        CH C CN    R    C
Sbjct: 823  GS-KDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGF-----PSCHPCPCN----RFAELC 872

Query: 445  DEESGRCL-CLPNVVGPKCDQCAP-YHWKLASGQGCEPCACDPHNSLSPQCNQFTGQ--- 499
            D E+G C  C     G  C++C   Y+   +SGQ C PC C       P  NQ+      
Sbjct: 873  DPETGSCFNCGGFTTGRNCERCIDGYYGNPSSGQPCRPCLCPD----DPSSNQYFAHSCY 928

Query: 500  ---------CPCREGFGGLMC-------------SAAAIRQCPDRTYGDV--------AT 529
                     C C +G+ G  C             S A  + C      DV         T
Sbjct: 929  QNLWSSDVICNCLQGYTGTQCGECSTGFYGNPRISGAPCQPCACNNNIDVTDPESCSRVT 988

Query: 530  G-----------------------------CRACDCDFRGTE----GPG-----CDKASG 551
            G                             CR C C   G       PG     CD  +G
Sbjct: 989  GECLRCLHNTQGANCQLCKPGHYGSALNQTCRRCSCHASGVSPMECPPGGGACLCDPVTG 1048

Query: 552  RCLCRPGLTGPRCDQCQRGYCNRYP--VCVAC 581
             C C P +TG  CD+C  GY N  P   C +C
Sbjct: 1049 ACPCLPNVTGLACDRCADGYWNLVPGRGCQSC 1080



 Score =  113 bits (282), Expect = 1e-24
 Identities = 73/236 (30%), Positives = 107/236 (45%), Gaps = 26/236 (11%)

Query: 370 ASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCH 429
           A + +  ++C+C P G+V G+ C  + GQC CK  V G  CD C  G   L +    GCH
Sbjct: 760 AKLHDGAVACKCHPQGSV-GSSCSRLGGQCQCKPLVVGRCCDRCSTGSYDLGH---HGCH 815

Query: 430 RCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSL 489
            C C+  GS +D  CD+ +G+C C   V G +CD+C   ++   S   C PC C   N  
Sbjct: 816 PCHCHPQGS-KDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFPS---CHPCPC---NRF 868

Query: 490 SPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATG--CRACDCD--------FR 539
           +  C+  TG C    GF     +     +C D  YG+ ++G  CR C C         F 
Sbjct: 869 AELCDPETGSCFNCGGF----TTGRNCERCIDGYYGNPSSGQPCRPCLCPDDPSSNQYFA 924

Query: 540 GTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVA-CHPCFQTYDADLRE 594
            +       +   C C  G TG +C +C  G+     +  A C PC    + D+ +
Sbjct: 925 HSCYQNLWSSDVICNCLQGYTGTQCGECSTGFYGNPRISGAPCQPCACNNNIDVTD 980



 Score = 40.0 bits (92), Expect = 0.013
 Identities = 26/91 (28%), Positives = 31/91 (34%), Gaps = 27/91 (29%)

Query: 279 CVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGA 338
           C+C     G +CE C   Y    W    G   H C  CDC+                 GA
Sbjct: 475 CLCLSYVTGAHCEECTVGY----W--GLGNHLHGCSPCDCD---------------IGGA 513

Query: 339 YGGVCD------NCRDHTEGKNCERCQLHYF 363
           Y  VC        CR H  G++C      YF
Sbjct: 514 YSNVCSPKNGQCECRPHVTGRSCSEPAPGYF 544


>gi|167614504 laminin, beta 1 precursor [Homo sapiens]
          Length = 1786

 Score =  424 bits (1090), Expect = e-118
 Identities = 218/517 (42%), Positives = 296/517 (57%), Gaps = 30/517 (5%)

Query: 21  CSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYC-TQYGEWQMKCCKCDSRQPH---- 75
           C+ G+CYP  GDLL+GR + L  +STCGL KPE YC   + +   KC  C+S+ P+    
Sbjct: 30  CAEGSCYPATGDLLIGRAQKLSVTSTCGLHKPEPYCIVSHLQEDKKCFICNSQDPYHETL 89

Query: 76  NYYSHRVENVASSSGPMR---WWQSQNDVNPVSLQLDLDRRFQLQEVMMEFQGPMPAGML 132
           N  SH +ENV ++  P R   WWQS+N V  V++QLDL+  F    ++M F+   PA ML
Sbjct: 90  NPDSHLIENVVTTFAPNRLKIWWQSENGVENVTIQLDLEAEFHFTHLIMTFKTFRPAAML 149

Query: 133 IERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQ--RPNARLNGGKVQ 190
           IERSSDFGKTW VY+Y A DC ++FP +  G  +   D+ C S      P+     G+V 
Sbjct: 150 IERSSDFGKTWGVYRYFAYDCEASFPGISTGPMKKVDDIICDSRYSDIEPSTE---GEVI 206

Query: 191 LNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPV-----PQRGYHPPSAYYAVSQLR 245
              +D    I    S +IQ + +ITNLR+ F +L  +       R       YYAV  + 
Sbjct: 207 FRALDPAFKIEDPYSPRIQNLLKITNLRIKFVKLHTLGDNLLDSRMEIREKYYYAVYDMV 266

Query: 246 LQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPA 305
           ++G+CFC+GHA  CAP  G +        VH  C+C+HNT G NCE C  FY++ PWRPA
Sbjct: 267 VRGNCFCYGHASECAPVDGFNE--EVEGMVHGHCMCRHNTKGLNCELCMDFYHDLPWRPA 324

Query: 306 EGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRN 365
           EG++++ C++C+CN HS +CHFD AV+ A+    GGVCD+C+ +T G+NCE+C+  Y+++
Sbjct: 325 EGRNSNACKKCNCNEHSISCHFDMAVYLATGNVSGGVCDDCQHNTMGRNCEQCKPFYYQH 384

Query: 366 RRPGASIQETCISCECDPDGAVPGAPCDPVT--------GQCVCKEHVQGERCDLCKPGF 417
                     C  C CDP G+     CD  T        GQC CK +V+GE CD+CK GF
Sbjct: 385 PERDIRDPNFCERCTCDPAGSQNEGICDSYTDFSTGLIAGQCRCKLNVEGEHCDVCKEGF 444

Query: 418 TGLTYANPQGCHRCDCNILGS-RRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASG- 475
             L+  +P GC  C CN LG+     PCD E+G C C   V G  CDQC P HW L++  
Sbjct: 445 YDLSSEDPFGCKSCACNPLGTIPGGNPCDSETGHCYCKRLVTGQHCDQCLPEHWGLSNDL 504

Query: 476 QGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCS 512
            GC PC CD   +L+  C   +GQC CR    G  C+
Sbjct: 505 DGCRPCDCDLGGALNNSCFAESGQCSCRPHMIGRQCN 541



 Score =  396 bits (1017), Expect = e-110
 Identities = 272/964 (28%), Positives = 461/964 (47%), Gaps = 87/964 (9%)

Query: 250  CFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERC-APFYNNRPWRPAEGQ 308
            C C+GHAD C P  G                CQ  T G NCERC A +Y +    P  G 
Sbjct: 867  CQCNGHADDCDPVTGECLN------------CQDYTMGHNCERCLAGYYGD----PIIGS 910

Query: 309  DAHECQRCDC-------NGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLH 361
              H C+ C C          + +C+ DP     +      VCD       G  C+ C   
Sbjct: 911  GDH-CRPCPCPDGPDSGRQFARSCYQDPVTLQLAC-----VCD---PGYIGSRCDDCASG 961

Query: 362  YFRNRRPGASIQETCISCEC--DPDGAVPGAPCDPVTGQCV-CKEHVQGERCDLCKPGFT 418
            YF N    + +  +C  C+C  + D   P A CD  TG+C+ C  H +GE C  C+ G+ 
Sbjct: 962  YFGNP---SEVGGSCQPCQCHNNIDTTDPEA-CDKETGRCLKCLYHTEGEHCQFCRFGYY 1017

Query: 419  GLTYANPQGCHRCDCNILGSRR------DMPCDEESGRCLCLPNVVGPKCDQCAPYHWKL 472
            G   A  Q C +C CN LG+ +      D  CD+ +G+CLCLPNV+G  CD+CAP  W+L
Sbjct: 1018 G--DALQQDCRKCVCNYLGTVQEHCNGSDCQCDKATGQCLCLPNVIGQNCDRCAPNTWQL 1075

Query: 473  ASGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCR 532
            ASG GC+PC C+  +S  P CN+FTGQC C  GFGG  CS     +C +  +GD    CR
Sbjct: 1076 ASGTGCDPCNCNAAHSFGPSCNEFTGQCQCMPGFGGRTCS-----ECQELFWGDPDVECR 1130

Query: 533  ACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADL 592
            ACDCD RG E P CD+++G+C+C  G+ GPRCD+C RGY   +P C  CH CF  +D  +
Sbjct: 1131 ACDCDPRGIETPQCDQSTGQCVCVEGVEGPRCDKCTRGYSGVFPDCTPCHQCFALWDVII 1190

Query: 593  REQALRFGR-LRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLS-SPAVTEQEVAQ 650
             E   R  R L  A A   SG     R     +   + K+ +I+ +L+ SPA   + +  
Sbjct: 1191 AELTNRTHRFLEKAKALKISGVIGPYRETVDSV---ERKVSEIKDILAQSPAA--EPLKN 1245

Query: 651  VASAILSLRRTLQGL-----QLDLPLEEETL---SLPRDLESLDRSFNGLLTMYQRKREQ 702
            + +      + ++ +     Q+++ L + T    S  ++L+SL      L    +   EQ
Sbjct: 1246 IGNLFEEAEKLIKDVTEMMAQVEVKLSDTTSQSNSTAKELDSLQTEAESLDNTVKELAEQ 1305

Query: 703  FEKISSADPSGAFRMLSTAYEQSAQAAQQVS-----------DSSRLLDQLRDSRREAER 751
             E I ++D  GA   ++  ++ S +A ++V+            S+ + D++ D   E E 
Sbjct: 1306 LEFIKNSDIRGALDSITKYFQMSLEAEERVNASTTEPNSTVEQSALMRDRVEDVMMERES 1365

Query: 752  LVRQAGGGGGTGSPKLVALRLEMSSLPDLTPTFNKLCGNSRQMACTPISCPGELCPQDNG 811
              ++        +  L  L  ++ SL DL+      CG     +C+   C G  C  D G
Sbjct: 1366 QFKEK---QEEQARLLDELAGKLQSL-DLSAAAEMTCGTPPGASCSETECGGPNCRTDEG 1421

Query: 812  -TACGS-RCRGVLPRAGGAFLMAGQVAEQLRGFNAQLQRTRQMIRAAEESASQIQSSAQR 869
               CG   C G++  A  A+  A  + + +    A++++  +M+  A+  A + + SA+ 
Sbjct: 1422 ERKCGGPGCGGLVTVAHNAWQKAMDLDQDVLSALAEVEQLSKMVSEAKLRADEAKQSAED 1481

Query: 870  LETQVSASRSQMEEDVRRTRLLIQQVRDFLTDPDTDAATIQEVSEAVLALWLPTDSATVL 929
            +  + +A++ +M++     R LI+Q+R+FLT    D  +I+ V+  VL + +P+    + 
Sbjct: 1482 ILLKTNATKEKMDKSNEELRNLIKQIRNFLTQDSADLDSIEAVANEVLKMEMPSTPQQLQ 1541

Query: 930  QKMNEIQAIAARLPNVDLVLSQTKQDIARARRLQAEAEEARSRAHAVEGQVEDVVGNLRQ 989
                +I+     L  V+++L  +  DIARA  L  EA+ A   A  V+   + V   L +
Sbjct: 1542 NLTEDIRERVESLSQVEVILQHSAADIARAEMLLEEAKRASKSATDVKVTADMVKEALEE 1601

Query: 990  GTVALQEAQDTMQGTSRSLRLIQDRVAEVQQVLRPAEKLVTSMTKQLGDFWTRMEELRHQ 1049
               A   A+  ++     ++  Q+ +  ++     +E+ + + ++++ +    +EEL+ +
Sbjct: 1602 AEKAQVAAEKAIKQADEDIQGTQNLLTSIESETAASEETLFNASQRISELERNVEELKRK 1661

Query: 1050 ARQQGAEAVQAQQLAEGASEQALSAQEGFE-RIKQKYAELKDRLGQSSMLGEQGAR-IQS 1107
            A Q   EA   +++     + A   ++  +  + +KY ++++ + + +       R  + 
Sbjct: 1662 AAQNSGEAEYIEKVVYTVKQSAEDVKKTLDGELDEKYKKVENLIAKKTEESADARRKAEM 1721

Query: 1108 VKTEAEELFGETMEMMDRMKDMELELLRGSQAIMLRSADLTGLEKRVEQIRDHINGRVLY 1167
            ++ EA+ L  +    +  +KD+E +     + +  ++ +L  LE  V  +   I+ +V  
Sbjct: 1722 LQNEAKTLLAQANSKLQLLKDLERKYEDNQRYLEDKAQELARLEGEVRSLLKDISQKVAV 1781

Query: 1168 YATC 1171
            Y+TC
Sbjct: 1782 YSTC 1785



 Score =  139 bits (350), Expect = 2e-32
 Identities = 81/233 (34%), Positives = 111/233 (47%), Gaps = 38/233 (16%)

Query: 370 ASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCH 429
           A + +T ++CECDP G++  + CDP  GQC C+ +V G  C+ C PG  G     P GC 
Sbjct: 764 ALLHQTGLACECDPQGSL-SSVCDPNGGQCQCRPNVVGRTCNRCAPGTFGF---GPSGCK 819

Query: 430 RCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSL 489
            C+C++ GS     C+  +G+C C   V   +CD+C P HW   S   C+PC C+ H   
Sbjct: 820 PCECHLQGSVNAF-CNPVTGQCHCFQGVYARQCDRCLPGHWGFPS---CQPCQCNGH--- 872

Query: 490 SPQCNQFTGQC-PCREGFGGLMCSAAAIRQCPDRTYGDVATG----CRACDCDFRGTEGP 544
           +  C+  TG+C  C++   G  C      +C    YGD   G    CR C C     +GP
Sbjct: 873 ADDCDPVTGECLNCQDYTMGHNC-----ERCLAGYYGDPIIGSGDHCRPCPC----PDGP 923

Query: 545 GCDKASGR------------CLCRPGLTGPRCDQCQRGYC-NRYPVCVACHPC 584
              +   R            C+C PG  G RCD C  GY  N   V  +C PC
Sbjct: 924 DSGRQFARSCYQDPVTLQLACVCDPGYIGSRCDDCASGYFGNPSEVGGSCQPC 976



 Score =  132 bits (332), Expect = 2e-30
 Identities = 89/289 (30%), Positives = 120/289 (41%), Gaps = 45/289 (15%)

Query: 316 CDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYF-----------R 364
           C C GH+  C          +G   G C  CR +T+G NCE C   Y             
Sbjct: 271 CFCYGHASECAPVDGFNEEVEGMVHGHC-MCRHNTKGLNCELCMDFYHDLPWRPAEGRNS 329

Query: 365 NRRPGASIQETCISCECD-----PDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGF-- 417
           N     +  E  ISC  D       G V G  CD       C+ +  G  C+ CKP +  
Sbjct: 330 NACKKCNCNEHSISCHFDMAVYLATGNVSGGVCDD------CQHNTMGRNCEQCKPFYYQ 383

Query: 418 -TGLTYANPQGCHRCDCNILGSRRDMPCDEES--------GRCLCLPNVVGPKCDQCAPY 468
                  +P  C RC C+  GS+ +  CD  +        G+C C  NV G  CD C   
Sbjct: 384 HPERDIRDPNFCERCTCDPAGSQNEGICDSYTDFSTGLIAGQCRCKLNVEGEHCDVCKEG 443

Query: 469 HWKLASGQ--GCEPCACDPHNSL--SPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTY 524
            + L+S    GC+ CAC+P  ++     C+  TG C C+    G  C      QC    +
Sbjct: 444 FYDLSSEDPFGCKSCACNPLGTIPGGNPCDSETGHCYCKRLVTGQHCD-----QCLPEHW 498

Query: 525 G--DVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGY 571
           G  +   GCR CDCD  G     C   SG+C CRP + G +C++ + GY
Sbjct: 499 GLSNDLDGCRPCDCDLGGALNNSCFAESGQCSCRPHMIGRQCNEVEPGY 547



 Score =  123 bits (308), Expect = 1e-27
 Identities = 102/335 (30%), Positives = 134/335 (40%), Gaps = 98/335 (29%)

Query: 325  CHFDPAVFAASQGAYGGVCD------NCRDHTEGKNCERCQLHYFRNRRPGASIQETCIS 378
            C  DP      QG+   VCD       CR +  G+ C RC    F     G      C  
Sbjct: 773  CECDP------QGSLSSVCDPNGGQCQCRPNVVGRTCNRCAPGTFGFGPSG------CKP 820

Query: 379  CECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGC--HRCDCN-- 434
            CEC   G+V  A C+PVTGQC C + V   +CD C PG  G     P  C  H  DC+  
Sbjct: 821  CECHLQGSV-NAFCNPVTGQCHCFQGVYARQCDRCLPGHWGFPSCQPCQCNGHADDCDPV 879

Query: 435  ---------------------------ILGSR---RDMPCDE--ESGR------------ 450
                                       I+GS    R  PC +  +SGR            
Sbjct: 880  TGECLNCQDYTMGHNCERCLAGYYGDPIIGSGDHCRPCPCPDGPDSGRQFARSCYQDPVT 939

Query: 451  ----CLCLPNVVGPKCDQCAPYHWKLAS--GQGCEPCACDPHNSLS----PQCNQFTGQC 500
                C+C P  +G +CD CA  ++   S  G  C+PC C  HN++       C++ TG+C
Sbjct: 940  LQLACVCDPGYIGSRCDDCASGYFGNPSEVGGSCQPCQC--HNNIDTTDPEACDKETGRC 997

Query: 501  -PCREGFGGLMCSAAAIRQCPDRTYGD-VATGCRACDCDFRGT-------EGPGCDKASG 551
              C     G  C     + C    YGD +   CR C C++ GT           CDKA+G
Sbjct: 998  LKCLYHTEGEHC-----QFCRFGYYGDALQQDCRKCVCNYLGTVQEHCNGSDCQCDKATG 1052

Query: 552  RCLCRPGLTGPRCDQCQRGYCNRYPVC--VACHPC 584
            +CLC P + G  CD+C     N + +     C PC
Sbjct: 1053 QCLCLPNVIGQNCDRCAP---NTWQLASGTGCDPC 1084



 Score = 77.8 bits (190), Expect = 6e-14
 Identities = 44/138 (31%), Positives = 65/138 (47%), Gaps = 12/138 (8%)

Query: 450 RCLCLPN----VVGPKCDQCAPYHWKLAS--GQGCEPCACDPHNSLSPQCNQFTGQCPCR 503
           R  CL N    V  P  D C    + +++   Q    C CDP  SLS  C+   GQC CR
Sbjct: 736 RYRCLENSRSVVKTPMTDVCRNIIFSISALLHQTGLACECDPQGSLSSVCDPNGGQCQCR 795

Query: 504 EGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPR 563
               G  C+     +C   T+G   +GC+ C+C  +G+    C+  +G+C C  G+   +
Sbjct: 796 PNVVGRTCN-----RCAPGTFGFGPSGCKPCECHLQGSVNAFCNPVTGQCHCFQGVYARQ 850

Query: 564 CDQCQRGYCNRYPVCVAC 581
           CD+C  G+   +P C  C
Sbjct: 851 CDRCLPGHWG-FPSCQPC 867


>gi|21264602 laminin alpha 5 [Homo sapiens]
          Length = 3695

 Score =  323 bits (829), Expect = 5e-88
 Identities = 215/648 (33%), Positives = 304/648 (46%), Gaps = 105/648 (16%)

Query: 3   PFFLLCFALPGLLHAQQACSRG-ACYPPVGDLLVGRTRFLRASSTCGLTKP--------- 52
           P  L+  AL G   A++    G + +PP  +L  G    + AS+TCG   P         
Sbjct: 21  PLLLVGLALLGAARAREEAGGGFSLHPPYFNLAEGAR--IAASATCGEEAPARGSPRPTE 78

Query: 53  ETYC--------------TQYGEWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQ 98
           + YC              T  G++   C   +S + H   +       +  G  RWWQS 
Sbjct: 79  DLYCKLVGGPVAGGDPNQTIRGQYCDICTAANSNKAHPASN-------AIDGTERWWQSP 131

Query: 99  N-----DVNPVSLQLDLDRRFQLQEVMMEF-QGPMPAGMLIERSSDFGKTWRVYQYLAA- 151
                 + N V++ LDL + F +  V+++F   P P   ++ERS DFG+T++ +Q+ A+ 
Sbjct: 132 PLSRGLEYNEVNVTLDLGQVFHVAYVLIKFANSPRPDLWVLERSMDFGRTYQPWQFFASS 191

Query: 152 --DCTSTFPRVRQGRPQSWQDVRCQSLPQRPNARLNGGKVQLNLMDLVSGIPATQ----S 205
             DC   F      R        C +   R     NG  V    + LV+G P       S
Sbjct: 192 KRDCLERFGPQTLERITRDDAAICTTEYSRIVPLENGEIV----VSLVNGRPGAMNFSYS 247

Query: 206 QKIQEVGEITNLRVNFTR----LAPVPQRGYHPPSA----YYAVSQLRLQGSCFCHGHAD 257
             ++E  + TN+R+ F R    L  +  +    P+     YY++  + + G C CHGHAD
Sbjct: 248 PLLREFTKATNVRLRFLRTNTLLGHLMGKALRDPTVTRRYYYSIKDISIGGRCVCHGHAD 307

Query: 258 RCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCD 317
            C  K      P+   ++   C CQHNT G  C+RC P +N +PW+PA    A+ECQ C+
Sbjct: 308 ACDAKD-----PTDPFRLQ--CTCQHNTCGGTCDRCCPGFNQQPWKPATANSANECQSCN 360

Query: 318 CNGHSETCHFDPAV--FAASQ---GAY--GGVCDNCRDHTEGKNCERCQLHYFRNRRPGA 370
           C GH+  C++DP V    ASQ   G Y  GGVC +C+ HT G NCERC   ++R+     
Sbjct: 361 CYGHATDCYYDPEVDRRRASQSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSPNHPL 420

Query: 371 SIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL--TYANPQGC 428
                C  C C+ D       C+ +TG+C C+ +  GERCD+C  GFTG    Y  P   
Sbjct: 421 DSPHVCRRCNCESD--FTDGTCEDLTGRCYCRPNFSGERCDVCAEGFTGFPSCYPTPSSS 478

Query: 429 H-------------RCDCNILGSRRDMPC--DEESGRCLCLPNVVGPKCDQCAPYHWKLA 473
           +              CDC+  G++ +  C  D   GRCLC PN  G  C+ CAP  +   
Sbjct: 479 NDTREQVLPAGQIVNCDCSAAGTQGN-ACRKDPRVGRCLCKPNFQGTHCELCAPGFY--- 534

Query: 474 SGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRA 533
            G GC+PC C        +C+  TGQC CR GF G  C   A    P   +  +   C+ 
Sbjct: 535 -GPGCQPCQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCA----PGYFHFPL---CQL 586

Query: 534 CDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVAC 581
           C C   GT   GCD+A GRCLC+P   GP CD+C+ GY + +P C AC
Sbjct: 587 CGCSPAGTLPEGCDEA-GRCLCQPEFAGPHCDRCRPGY-HGFPNCQAC 632



 Score =  216 bits (550), Expect = 1e-55
 Identities = 255/957 (26%), Positives = 362/957 (37%), Gaps = 176/957 (18%)

Query: 250  CFCHGHADRCAPKPGASAGPSTAVQVHDVCV-CQHNTAGPNCERC-APFYNNRPWRPAEG 307
            C CHGH+DRC P  G             VCV CQHNT G +CERC A F ++R       
Sbjct: 1864 CQCHGHSDRCLPGSG-------------VCVDCQHNTEGAHCERCQAGFVSSRD------ 1904

Query: 308  QDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDN------CRDHTEGKNCERCQLH 361
              +  C  C C          P    ++  A G V         C+    G +CERC   
Sbjct: 1905 DPSAPCVSCPC----------PLSVPSNNFAEGCVLRGGRTQCLCKPGYAGASCERCAPG 1954

Query: 362  YFRNRRPGASIQETCISCECDPDGA--VPGAPCDPVTGQCV-CKEHVQGERCDLCKPGFT 418
            +F N      +  +C  C+C  +G   +  + CDP+TG C  C  H  G RC++C PGF 
Sbjct: 1955 FFGNP---LVLGSSCQPCDCSGNGDPNLLFSDCDPLTGACRGCLRHTTGPRCEICAPGFY 2011

Query: 419  GLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGC 478
            G     P  C RCDC   G+     CD  SG CLC   V G +CD+C   H+      GC
Sbjct: 2012 GNALL-PGNCTRCDCTPCGTEA---CDPHSGHCLCKAGVTGRRCDRCQEGHFGFDGCGGC 2067

Query: 479  EPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDF 538
             PCAC P    S +C+  +GQC CR G  G  C     R+C    +G    GCR C C  
Sbjct: 2068 RPCACGPAAEGS-ECHPQSGQCHCRPGTMGPQC-----RECAPGYWGLPEQGCRRCQC-- 2119

Query: 539  RGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPV----------CVACHPCFQTY 588
                G  CD  +GRC C PGL+G RCD C + +  + PV          C  C  C    
Sbjct: 2120 ---PGGRCDPHTGRCNCPPGLSGERCDTCSQQH--QVPVPGGPVGHSIHCEVCDHCVVLL 2174

Query: 589  DADLREQALRFGRLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEV 648
              DL     R G L  A      G        A R+    + I  +++ L SP     E 
Sbjct: 2175 LDDLE----RAGALLPAIHEQLRGINASSMAWA-RLHRLNASIADLQSQLRSPLGPRHET 2229

Query: 649  AQVASAILSLRRTLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISS 708
            AQ               QL++ LE+++ SL +D   L     G        R+Q      
Sbjct: 2230 AQ---------------QLEV-LEQQSTSLGQDARRLGGQAVG-------TRDQ------ 2260

Query: 709  ADPSGAFRMLSTAYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAG--GGGGTGSPK 766
                        A +  A     +  +  LL  +R   R    L+ Q G  G     +P 
Sbjct: 2261 ------------ASQLLAGTEATLGHAKTLLAAIRAVDRTLSELMSQTGHLGLANASAPS 2308

Query: 767  LVALRLEMSSLPDLTPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAG 826
               L   ++ +  L          +R +     +   EL       A        L    
Sbjct: 2309 GEQLLRTLAEVERLLWEM-----RARDLGAPQAAAEAELAAAQRLLARVQEQLSSLWEEN 2363

Query: 827  GAFLMAGQVAEQLRGFNAQLQRTRQMIRAAEES---ASQIQSSAQRLETQVSASRSQMEE 883
             A  +A Q  ++L    A L   R+ +  A ++   A ++ S  Q    +    + ++  
Sbjct: 2364 QA--LATQTRDRLAQHEAGLMDLREALNRAVDATREAQELNSRNQERLEEALQRKQELSR 2421

Query: 884  DVRRTRLLIQQVRDFLTDPDTDAATIQEVSEAVLALWLPTDSA--TVLQKMNEI------ 935
            D    +  +   RD L        ++ +  E +  L    D A   +LQ+M         
Sbjct: 2422 DNATLQATLHAARDTLASVFRLLHSLDQAKEELERLAASLDGARTPLLQRMQTFSPAGSK 2481

Query: 936  -------QAIAARLPNVDLVLSQTKQDIARARRLQ--AEAEEARSRAHAVEGQVEDVVGN 986
                   +A A +L  + L LS    D+ + R  Q   EA  A SR        ED  G 
Sbjct: 2482 LRLVEAAEAHAQQLGQLALNLSSIILDVNQDRLTQRAIEASNAYSRILQAVQAAEDAAGQ 2541

Query: 987  LRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQVLRPAEKLVTSMTKQ---LGDFWTRM 1043
                  ALQ+A  T     R     Q  V   QQ+L  +  L  +M ++   LG  W  +
Sbjct: 2542 ------ALQQADHTWATVVR-----QGLVDRAQQLLANSTALEEAMLQEQQRLGLVWAAL 2590

Query: 1044 EELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFERIKQKYAELKDRLGQSSMLGEQGA 1103
            +  R Q R   A+  Q +   + A  QA+ A +  E  K K A  K             A
Sbjct: 2591 QGARTQLRDVRAKKDQLEAHIQAA--QAMLAMDTDETSK-KIAHAK----------AVAA 2637

Query: 1104 RIQSVKTEAEELFGETMEMMDRMKDMELELLRG---SQAIMLRSADLTGLEKRVEQI 1157
              Q   T  +       E ++R +  + E LRG    QA++     ++ LEK + Q+
Sbjct: 2638 EAQDTATRVQSQLQAMQENVERWQG-QYEGLRGQDLGQAVLDAGHSVSTLEKTLPQL 2693



 Score =  171 bits (434), Expect = 3e-42
 Identities = 101/300 (33%), Positives = 132/300 (44%), Gaps = 45/300 (15%)

Query: 279 CVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGA 338
           C+CQ   AGP+C+RC P Y+  P           CQ C C         DP         
Sbjct: 605 CLCQPEFAGPHCDRCRPGYHGFP----------NCQACTC---------DPRGALDQLCG 645

Query: 339 YGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQ 398
            GG+C  CR    G  C+ C         PG     +C+ C C  +G++  A CDP +GQ
Sbjct: 646 AGGLC-RCRPGYTGTACQECS--------PGFHGFPSCVPCHCSAEGSLHAA-CDPRSGQ 695

Query: 399 CVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVV 458
           C C+  V G RCD C PG     Y     CH      +    D    E    C+C  +V 
Sbjct: 696 CSCRPRVTGLRCDTCVPGAYNFPYCEAGSCHPAGLAPV----DPALPEAQVPCMCRAHVE 751

Query: 459 GPKCDQCAPYHWKLASG--QGCEPCACDPHNSLS--PQCNQFTGQCPCREGFGGLMCSAA 514
           GP CD+C P  W L+    +GC  C+CD   +L    +C   TGQC C+    G  C++ 
Sbjct: 752 GPSCDRCKPGFWGLSPSNPEGCTRCSCDLRGTLGGVAECQPGTGQCFCKPHVCGQACAS- 810

Query: 515 AIRQCPDRTYG-DVAT--GCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGY 571
               C D  +G D A   GCR+C CD  G  G  C+  +G C CRP   GP C +  R +
Sbjct: 811 ----CKDGFFGLDQADYFGCRSCRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDH 866



 Score =  127 bits (318), Expect = 8e-29
 Identities = 70/195 (35%), Positives = 86/195 (44%), Gaps = 22/195 (11%)

Query: 379  CECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGS 438
            C C   GA  G  C+P  GQC C  HV G  C  C  G+ G        C  CDC   G+
Sbjct: 1438 CGCHEVGAT-GPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFP-----NCRPCDC---GA 1488

Query: 439  RRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDP---HNSLSPQCNQ 495
            R    CDE +G+C+C P  + P C  C P  +      GCE C C          P C+ 
Sbjct: 1489 RL---CDELTGQCICPPRTIPPDCLLCQPQTFGCHPLVGCEECNCSGPGIQELTDPTCDT 1545

Query: 496  FTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLC 555
             +GQC CR    G  C       C    +G     CR CDC   GT    CD  +G+C C
Sbjct: 1546 DSGQCKCRPNVTGRRCDT-----CSPGFHG--YPRCRPCDCHEAGTAPGVCDPLTGQCYC 1598

Query: 556  RPGLTGPRCDQCQRG 570
            +  + GP+CDQC  G
Sbjct: 1599 KENVQGPKCDQCSLG 1613



 Score =  114 bits (285), Expect = 5e-25
 Identities = 83/271 (30%), Positives = 105/271 (38%), Gaps = 54/271 (19%)

Query: 248 GSCFCHG-----HADRCAPKPGASAGPSTAVQVHD-------------VCVCQHNTAGPN 289
           G C C       H DRC  +PG    P+      D             +C C+    G  
Sbjct: 603 GRCLCQPEFAGPHCDRC--RPGYHGFPNCQACTCDPRGALDQLCGAGGLCRCRPGYTGTA 660

Query: 290 CERCAPFYNNRP-----WRPAEGQDAHECQ----RCDCNGHSETCHFDPAVFAASQGAY- 339
           C+ C+P ++  P        AEG     C     +C C         D  V  A    Y 
Sbjct: 661 CQECSPGFHGFPSCVPCHCSAEGSLHAACDPRSGQCSCRPRVTGLRCDTCVPGAYNFPYC 720

Query: 340 -GGVCDN------------------CRDHTEGKNCERCQLHYFRNRRPGASIQETCISCE 380
             G C                    CR H EG +C+RC+  ++       S  E C  C 
Sbjct: 721 EAGSCHPAGLAPVDPALPEAQVPCMCRAHVEGPSCDRCKPGFWGL---SPSNPEGCTRCS 777

Query: 381 CDPDGAVPG-APCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSR 439
           CD  G + G A C P TGQC CK HV G+ C  CK GF GL  A+  GC  C C+I G  
Sbjct: 778 CDLRGTLGGVAECQPGTGQCFCKPHVCGQACASCKDGFFGLDQADYFGCRSCRCDI-GGA 836

Query: 440 RDMPCDEESGRCLCLPNVVGPKCDQCAPYHW 470
               C+  +G C C PN  GP C + A  H+
Sbjct: 837 LGQSCEPRTGVCRCRPNTQGPTCSEPARDHY 867



 Score =  104 bits (260), Expect = 4e-22
 Identities = 67/199 (33%), Positives = 83/199 (41%), Gaps = 36/199 (18%)

Query: 248  GSCFCHGHA-----DRCAP--------KPGASAGPSTAVQVHDVCVCQHNTAGPNCERCA 294
            G C CH H       RCA         +P    G     ++   C+C   T  P+C  C 
Sbjct: 1455 GQCPCHAHVIGRDCSRCATGYWGFPNCRP-CDCGARLCDELTGQCICPPRTIPPDCLLCQ 1513

Query: 295  PFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKN 354
            P        P  G     C+ C+C+G       DP     S     G C  CR +  G+ 
Sbjct: 1514 P--QTFGCHPLVG-----CEECNCSGPGIQELTDPTCDTDS-----GQC-KCRPNVTGRR 1560

Query: 355  CERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCK 414
            C+ C         PG      C  C+C   G  PG  CDP+TGQC CKE+VQG +CD C 
Sbjct: 1561 CDTCS--------PGFHGYPRCRPCDCHEAGTAPGV-CDPLTGQCYCKENVQGPKCDQCS 1611

Query: 415  PGFTGLTYANPQGCHRCDC 433
             G   L  ANP+GC RC C
Sbjct: 1612 LGTFSLDAANPKGCTRCFC 1630



 Score = 94.0 bits (232), Expect = 8e-19
 Identities = 55/173 (31%), Positives = 77/173 (44%), Gaps = 19/173 (10%)

Query: 413  CKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKL 472
            C+     L+     G   C C+ +G+     C+   G+C C  +V+G  C +CA  +W  
Sbjct: 1420 CRNAAASLSLFYNNGARPCGCHEVGATGPT-CEPFGGQCPCHAHVIGRDCSRCATGYWGF 1478

Query: 473  ASGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYG-DVATGC 531
             +   C PC C         C++ TGQC C        C       C  +T+G     GC
Sbjct: 1479 PN---CRPCDCGAR-----LCDELTGQCICPPRTIPPDCLL-----CQPQTFGCHPLVGC 1525

Query: 532  RACDCDFRGTE---GPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVAC 581
              C+C   G +    P CD  SG+C CRP +TG RCD C  G+ + YP C  C
Sbjct: 1526 EECNCSGPGIQELTDPTCDTDSGQCKCRPNVTGRRCDTCSPGF-HGYPRCRPC 1577



 Score = 36.2 bits (82), Expect = 0.19
 Identities = 23/75 (30%), Positives = 32/75 (42%), Gaps = 8/75 (10%)

Query: 253  HGHADRCAPKPGASAG--PSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDA 310
            HG+  RC P     AG  P     +   C C+ N  GP C++C+    +      +G   
Sbjct: 1569 HGYP-RCRPCDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCSLGTFSLDAANPKG--- 1624

Query: 311  HECQRCDCNGHSETC 325
              C RC C G +E C
Sbjct: 1625 --CTRCFCFGATERC 1637


>gi|93204871 netrin 4 [Homo sapiens]
          Length = 628

 Score =  305 bits (782), Expect = 1e-82
 Identities = 181/467 (38%), Positives = 246/467 (52%), Gaps = 48/467 (10%)

Query: 11  LPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYC-----TQYGEWQMK 65
           L G+      C + AC P +G+L +GR   L A +TCG    E YC     T     Q K
Sbjct: 20  LSGVAGVSSRCEK-ACNPRMGNLALGRK--LWADTTCGQNATELYCFYSENTDLTCRQPK 76

Query: 66  CCKCDSRQPHNYYSHRVENVASSSG--PMRWWQSQNDVNPVSLQLDLDRRFQLQEVMMEF 123
           C KC++  PH   +H    +A SS   P  WWQS  DV+   +QLDL+  F    +++ F
Sbjct: 77  CDKCNAAYPH--LAHLPSAMADSSFRFPRTWWQSAEDVHREKIQLDLEAEFYFTHLIVMF 134

Query: 124 QGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPR----VRQGRPQSWQDVRCQSLPQR 179
           + P PA M+++RS DFGKTW+ Y+Y A +C++TF      V++G         C S    
Sbjct: 135 KSPRPAAMVLDRSQDFGKTWKPYKYFATNCSATFGLEDDVVKKG-------AICTSKYSS 187

Query: 180 PNARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVP-QRG--YHPPS 236
           P     GG+V    +          S K+QE  +ITNLRV   +    P QR      P 
Sbjct: 188 PFP-CTGGEVIFKALSPPYDTENPYSAKVQEQLKITNLRVQLLKRQSCPCQRNDLNEEPQ 246

Query: 237 --AYYAVSQLRLQGSCFCHGHADRCAPKPGASA--GPSTAVQVHDVCVCQHNTAGPNCER 292
              +YA+    ++GSCFC+GHAD+C P  G      P T   VH  C+C+HNTAG +C+ 
Sbjct: 247 HFTHYAIYDFIVKGSCFCNGHADQCIPVHGFRPVKAPGTFHMVHGKCMCKHNTAGSHCQH 306

Query: 293 CAPFYNNRPWRPAEGQDA--HECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHT 350
           CAP YN+RPW  A+G+    +EC+ C CNGH++TCHFD  V+ AS    GGVCD+C+ +T
Sbjct: 307 CAPLYNDRPWEAADGKTGAPNECRTCKCNGHADTCHFDVNVWEASGNRSGGVCDDCQHNT 366

Query: 351 EGKNCERCQLHYFRNRRPGASIQETCISCECDPDGA--VPGAP---CDPVTGQCVCKEHV 405
           EG+ C+RC+  ++R+ R   S  + C  C C P G+  +P      CDP  G C CK  V
Sbjct: 367 EGQYCQRCKPGFYRDLRRPFSAPDACKPCSCHPVGSAVLPANSVTFCDPSNGDCPCKPGV 426

Query: 406 QGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCL 452
            G RCD C  G+ G       GC  CDC   GS     CD  +G C+
Sbjct: 427 AGRRCDRCMVGYWGF---GDYGCRPCDC--AGS-----CDPITGDCI 463



 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 62/218 (28%), Positives = 88/218 (40%), Gaps = 50/218 (22%)

Query: 316 CDCNGHSETC----HFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGAS 371
           C CNGH++ C     F P     +     G C  C+ +T G +C+ C   Y  N RP  +
Sbjct: 262 CFCNGHADQCIPVHGFRPVKAPGTFHMVHGKC-MCKHNTAGSHCQHCAPLY--NDRPWEA 318

Query: 372 IQ------ETCISCEC--------------DPDGAVPGAPCDPVTGQCVCKEHVQGERCD 411
                     C +C+C              +  G   G  CD       C+ + +G+ C 
Sbjct: 319 ADGKTGAPNECRTCKCNGHADTCHFDVNVWEASGNRSGGVCDD------CQHNTEGQYCQ 372

Query: 412 LCKPGF---TGLTYANPQGCHRCDCNILGSRRDMP------CDEESGRCLCLPNVVGPKC 462
            CKPGF       ++ P  C  C C+ +GS   +P      CD  +G C C P V G +C
Sbjct: 373 RCKPGFYRDLRRPFSAPDACKPCSCHPVGSAV-LPANSVTFCDPSNGDCPCKPGVAGRRC 431

Query: 463 DQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQC 500
           D+C   +W      GC PC C      +  C+  TG C
Sbjct: 432 DRCMVGYWGFGD-YGCRPCDC------AGSCDPITGDC 462



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 53/204 (25%), Positives = 77/204 (37%), Gaps = 47/204 (23%)

Query: 449 GRCLCLPNVVGPKCDQCAPYH----WKLASGQG-----CEPCACDPH--------NSLSP 491
           G+C+C  N  G  C  CAP +    W+ A G+      C  C C+ H        N    
Sbjct: 291 GKCMCKHNTAGSHCQHCAPLYNDRPWEAADGKTGAPNECRTCKCNGHADTCHFDVNVWEA 350

Query: 492 QCNQFTGQCP-CREGFGGLMCSAAAIRQCPDRTYGDVAT------GCRACDCDFRGT--- 541
             N+  G C  C+    G  C     ++C    Y D+         C+ C C   G+   
Sbjct: 351 SGNRSGGVCDDCQHNTEGQYC-----QRCKPGFYRDLRRPFSAPDACKPCSCHPVGSAVL 405

Query: 542 ---EGPGCDKASGRCLCRPGLTGPRCDQCQRGY-------CNRYPVCVACHP----CFQT 587
                  CD ++G C C+PG+ G RCD+C  GY       C       +C P    C  +
Sbjct: 406 PANSVTFCDPSNGDCPCKPGVAGRRCDRCMVGYWGFGDYGCRPCDCAGSCDPITGDCISS 465

Query: 588 Y-DADLREQALRFGRLRNATASLW 610
           + D D   +   F  + N +   W
Sbjct: 466 HTDIDWYHEVPDFRPVHNKSEPAW 489


>gi|219842266 usherin isoform B [Homo sapiens]
          Length = 5202

 Score =  298 bits (762), Expect = 3e-80
 Identities = 164/499 (32%), Positives = 253/499 (50%), Gaps = 38/499 (7%)

Query: 104 VSLQLDLDR-RFQLQEVMMEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQ 162
           V++ +DL+  ++Q+  ++++F  P P  + I+R  +    W  +QY A +C   F     
Sbjct: 369 VTISVDLENGQYQVFYIIIQFFSPQPTEIRIQRKKENSLDWEDWQYFARNC-GAFGMKNN 427

Query: 163 GRPQSWQDVRCQSLPQ-RPNARLNGGKVQLNLMDLVSGIPATQSQ-----KIQEVGEITN 216
           G  +    V C  L    P +R   G V  +++          +       +QE  + T 
Sbjct: 428 GDLEKPDSVNCLQLSNFTPYSR---GNVTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQ 484

Query: 217 LRVNFTRLAPVPQRGYHPPSAYYAVSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVH 276
           +R +F       +   +    YYAV ++ + G C CHGHAD C          +T+    
Sbjct: 485 IRFHFHGQYYTTETAVNLRHRYYAVDEITISGRCQCHGHADNC---------DTTSQPYR 535

Query: 277 DVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHF----DPAVF 332
            +C  +  T G +C+RC P YN++P+R  +   A  C+ C CN HS++CH+    DP  F
Sbjct: 536 CLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPF 595

Query: 333 AASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGA-P 391
              +G  GGVCD+C  +T G+NCE C+ ++FR      S  + C  C+CD  G   G+  
Sbjct: 596 EHFRGG-GGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSIL 654

Query: 392 CDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGS-RRDMPCDEESGR 450
           CD + GQC CK HV G +C+ C+ GF  L   +P GC  C+CN  G+   D+ C + SG+
Sbjct: 655 CDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQ 714

Query: 451 CLCLPNVVGPKCDQCAPYHWKLA---SGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFG 507
           C C  NV+G +CD C  + +K     +  GCEPC C+ H S++  CN  +GQC C++   
Sbjct: 715 CKCKANVIGLRCDHC-NFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAK 773

Query: 508 GLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGT-EGPGCDKASGRCLCRPGLTGPRCDQ 566
           GL C       C +  YG   T C+ACDCD  G+  G  C+  +G+C+C+P + G +C++
Sbjct: 774 GLQCDT-----CRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNK 828

Query: 567 CQRG-YCNRYPVCVACHPC 584
           C  G +  R      C PC
Sbjct: 829 CLEGNFYLRQNNSFLCLPC 847



 Score =  179 bits (453), Expect = 2e-44
 Identities = 110/336 (32%), Positives = 154/336 (45%), Gaps = 46/336 (13%)

Query: 264 GASAGPSTAVQVHDVCVCQHNTAGPNCERCAP-FYNNRPWRPAEGQDAHECQRCDCNGHS 322
           G   G     Q+   C C+ + +G  C +C   FYN       +  D   C  C+CN   
Sbjct: 647 GTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYN------LQELDPDGCSPCNCNTSG 700

Query: 323 E-----TCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQET-C 376
                 TCH +            G C  C+ +  G  C+ C   +   R    S  +  C
Sbjct: 701 TVDGDITCHQN-----------SGQC-KCKANVIGLRCDHCNFGFKFLR----SFNDVGC 744

Query: 377 ISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNIL 436
             C+C+  G+V    C+P +GQC CK+  +G +CD C+  F GL   N   C  CDC+  
Sbjct: 745 EPCQCNLHGSV-NKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTN---CKACDCDTA 800

Query: 437 GSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQG--CEPCACDPHNSLSPQ-- 492
           GS     C+ ++G+C+C PNV G +C++C   ++ L       C PC CD   +++    
Sbjct: 801 GSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLL 860

Query: 493 CNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYG---DVATGCRACDCDFRGT-EGPGCDK 548
           CN+ TGQCPC+ G  GL C+     QC    Y    D    C+ C+CD  GT  G  CD 
Sbjct: 861 CNKSTGQCPCKLGVTGLRCN-----QCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDP 915

Query: 549 ASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPC 584
            SG+CLC P   G RC+QCQ G+         C PC
Sbjct: 916 ISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPC 951



 Score =  177 bits (449), Expect = 5e-44
 Identities = 107/325 (32%), Positives = 150/325 (46%), Gaps = 45/325 (13%)

Query: 250  CFCHGHADR-CAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAP-FYNNRPWRPAEG 307
            C  HG  ++ C P  G              C C+    G  C+ C   FY         G
Sbjct: 749  CNLHGSVNKFCNPHSGQ-------------CECKKEAKGLQCDTCRENFY---------G 786

Query: 308  QDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRR 367
             D   C+ CDC    +T    P        A  G C  C+ + EG+ C +C    F  R+
Sbjct: 787  LDVTNCKACDC----DTAGSLPGTVC---NAKTGQCI-CKPNVEGRQCNKCLEGNFYLRQ 838

Query: 368  PGASIQETCISCECDPDGAVPGAP-CDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQ 426
              + +   C+ C CD  G + G+  C+  TGQC CK  V G RC+ C+P    LT  N Q
Sbjct: 839  NNSFL---CLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQ 895

Query: 427  GCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAP-YHWKLASGQGCEPCACDP 485
             C  C+C+ LG+     CD  SG+CLC+PN  G +C+QC P ++    +  GC PC+C  
Sbjct: 896  HCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHT 955

Query: 486  HNSLSPQCNQFTGQCPCRE-GFGGLMCSAAAIRQCPDRTYG-DVATG-CRACDCDFRGTE 542
              +++  CN  TGQC C++    G  C      QC D  +G D  TG C+ C+C   G  
Sbjct: 956  TGAVNHICNSLTGQCVCQDASIAGQRCD-----QCKDHYFGFDPQTGRCQPCNCHLSGAL 1010

Query: 543  GPGCDKASGRCLCRPGLTGPRCDQC 567
               C   +G+C C+  +TG +CD C
Sbjct: 1011 NETCHLVTGQCFCKQFVTGSKCDAC 1035



 Score =  165 bits (418), Expect = 2e-40
 Identities = 101/339 (29%), Positives = 153/339 (45%), Gaps = 36/339 (10%)

Query: 257  DRCAP----KPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHE 312
            D C+P      G   G  T  Q    C C+ N  G  C+ C     N  ++     +   
Sbjct: 689  DGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHC-----NFGFKFLRSFNDVG 743

Query: 313  CQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASI 372
            C+ C CN H     F           + G C+ C+   +G  C+ C+ +++     G  +
Sbjct: 744  CEPCQCNLHGSVNKFC--------NPHSGQCE-CKKEAKGLQCDTCRENFY-----GLDV 789

Query: 373  QETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCD 432
               C +C+CD  G++PG  C+  TGQC+CK +V+G +C+ C  G   L   N   C  C+
Sbjct: 790  TN-CKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCN 848

Query: 433  CNILGS-RRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLA--SGQGCEPCACDPHNSL 489
            C+  G+    + C++ +G+C C   V G +C+QC P+ + L   + Q C+ C CD   +L
Sbjct: 849  CDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTL 908

Query: 490  SPQ-CNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDV--ATGCRACDCDFRGTEGPGC 546
                C+  +GQC C     G  C+     QC    Y     ATGC  C C   G     C
Sbjct: 909  PGTICDPISGQCLCVPNRQGRRCN-----QCQPGFYISPGNATGCLPCSCHTTGAVNHIC 963

Query: 547  DKASGRCLCRPG-LTGPRCDQCQRGYCNRYPVCVACHPC 584
            +  +G+C+C+   + G RCDQC+  Y    P    C PC
Sbjct: 964  NSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPC 1002



 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 60/199 (30%), Positives = 90/199 (45%), Gaps = 39/199 (19%)

Query: 279  CVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGA 338
            C C+    G  C +C P   N         +   CQ C+C+               S G 
Sbjct: 868  CPCKLGVTGLRCNQCEPHRYNLTI-----DNFQHCQMCECD---------------SLGT 907

Query: 339  YGG-VCDN------CRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAP 391
              G +CD       C  + +G+ C +CQ  ++ +  PG +    C+ C C   GAV    
Sbjct: 908  LPGTICDPISGQCLCVPNRQGRRCNQCQPGFYIS--PGNATG--CLPCSCHTTGAVNHI- 962

Query: 392  CDPVTGQCVCKE-HVQGERCDLCKPGFTGLTYANPQG--CHRCDCNILGSRRDMPCDEES 448
            C+ +TGQCVC++  + G+RCD CK  + G    +PQ   C  C+C++ G+  +  C   +
Sbjct: 963  CNSLTGQCVCQDASIAGQRCDQCKDHYFGF---DPQTGRCQPCNCHLSGALNET-CHLVT 1018

Query: 449  GRCLCLPNVVGPKCDQCAP 467
            G+C C   V G KCD C P
Sbjct: 1019 GQCFCKQFVTGSKCDACVP 1037



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 52/182 (28%), Positives = 73/182 (40%), Gaps = 40/182 (21%)

Query: 257  DRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRC 316
            D     PG    P     +   C+C  N  G  C +C P +   P       +A  C  C
Sbjct: 903  DSLGTLPGTICDP-----ISGQCLCVPNRQGRRCNQCQPGFYISPG------NATGCLPC 951

Query: 317  DCNGHSETCHFDPAVFAASQGAYGGVCDN------CRDHT-EGKNCERCQLHYFRNRRPG 369
             C+               + GA   +C++      C+D +  G+ C++C+ HYF     G
Sbjct: 952  SCH---------------TTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYF-----G 991

Query: 370  ASIQE-TCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGC 428
               Q   C  C C   GA+    C  VTGQC CK+ V G +CD C P  + L   N  GC
Sbjct: 992  FDPQTGRCQPCNCHLSGAL-NETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGC 1050

Query: 429  HR 430
             +
Sbjct: 1051 SK 1052


>gi|219842259 usherin isoform A [Homo sapiens]
          Length = 1546

 Score =  298 bits (762), Expect = 3e-80
 Identities = 164/499 (32%), Positives = 253/499 (50%), Gaps = 38/499 (7%)

Query: 104 VSLQLDLDR-RFQLQEVMMEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQ 162
           V++ +DL+  ++Q+  ++++F  P P  + I+R  +    W  +QY A +C   F     
Sbjct: 369 VTISVDLENGQYQVFYIIIQFFSPQPTEIRIQRKKENSLDWEDWQYFARNC-GAFGMKNN 427

Query: 163 GRPQSWQDVRCQSLPQ-RPNARLNGGKVQLNLMDLVSGIPATQSQ-----KIQEVGEITN 216
           G  +    V C  L    P +R   G V  +++          +       +QE  + T 
Sbjct: 428 GDLEKPDSVNCLQLSNFTPYSR---GNVTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQ 484

Query: 217 LRVNFTRLAPVPQRGYHPPSAYYAVSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVH 276
           +R +F       +   +    YYAV ++ + G C CHGHAD C          +T+    
Sbjct: 485 IRFHFHGQYYTTETAVNLRHRYYAVDEITISGRCQCHGHADNC---------DTTSQPYR 535

Query: 277 DVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHF----DPAVF 332
            +C  +  T G +C+RC P YN++P+R  +   A  C+ C CN HS++CH+    DP  F
Sbjct: 536 CLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPF 595

Query: 333 AASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGA-P 391
              +G  GGVCD+C  +T G+NCE C+ ++FR      S  + C  C+CD  G   G+  
Sbjct: 596 EHFRGG-GGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSIL 654

Query: 392 CDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGS-RRDMPCDEESGR 450
           CD + GQC CK HV G +C+ C+ GF  L   +P GC  C+CN  G+   D+ C + SG+
Sbjct: 655 CDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQ 714

Query: 451 CLCLPNVVGPKCDQCAPYHWKLA---SGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFG 507
           C C  NV+G +CD C  + +K     +  GCEPC C+ H S++  CN  +GQC C++   
Sbjct: 715 CKCKANVIGLRCDHC-NFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAK 773

Query: 508 GLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGT-EGPGCDKASGRCLCRPGLTGPRCDQ 566
           GL C       C +  YG   T C+ACDCD  G+  G  C+  +G+C+C+P + G +C++
Sbjct: 774 GLQCDT-----CRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNK 828

Query: 567 CQRG-YCNRYPVCVACHPC 584
           C  G +  R      C PC
Sbjct: 829 CLEGNFYLRQNNSFLCLPC 847



 Score =  179 bits (453), Expect = 2e-44
 Identities = 110/336 (32%), Positives = 154/336 (45%), Gaps = 46/336 (13%)

Query: 264 GASAGPSTAVQVHDVCVCQHNTAGPNCERCAP-FYNNRPWRPAEGQDAHECQRCDCNGHS 322
           G   G     Q+   C C+ + +G  C +C   FYN       +  D   C  C+CN   
Sbjct: 647 GTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYN------LQELDPDGCSPCNCNTSG 700

Query: 323 E-----TCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQET-C 376
                 TCH +            G C  C+ +  G  C+ C   +   R    S  +  C
Sbjct: 701 TVDGDITCHQN-----------SGQC-KCKANVIGLRCDHCNFGFKFLR----SFNDVGC 744

Query: 377 ISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNIL 436
             C+C+  G+V    C+P +GQC CK+  +G +CD C+  F GL   N   C  CDC+  
Sbjct: 745 EPCQCNLHGSV-NKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTN---CKACDCDTA 800

Query: 437 GSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQG--CEPCACDPHNSLSPQ-- 492
           GS     C+ ++G+C+C PNV G +C++C   ++ L       C PC CD   +++    
Sbjct: 801 GSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLL 860

Query: 493 CNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYG---DVATGCRACDCDFRGT-EGPGCDK 548
           CN+ TGQCPC+ G  GL C+     QC    Y    D    C+ C+CD  GT  G  CD 
Sbjct: 861 CNKSTGQCPCKLGVTGLRCN-----QCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDP 915

Query: 549 ASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPC 584
            SG+CLC P   G RC+QCQ G+         C PC
Sbjct: 916 ISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPC 951



 Score =  177 bits (449), Expect = 5e-44
 Identities = 107/325 (32%), Positives = 150/325 (46%), Gaps = 45/325 (13%)

Query: 250  CFCHGHADR-CAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAP-FYNNRPWRPAEG 307
            C  HG  ++ C P  G              C C+    G  C+ C   FY         G
Sbjct: 749  CNLHGSVNKFCNPHSGQ-------------CECKKEAKGLQCDTCRENFY---------G 786

Query: 308  QDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRR 367
             D   C+ CDC    +T    P        A  G C  C+ + EG+ C +C    F  R+
Sbjct: 787  LDVTNCKACDC----DTAGSLPGTVC---NAKTGQCI-CKPNVEGRQCNKCLEGNFYLRQ 838

Query: 368  PGASIQETCISCECDPDGAVPGAP-CDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQ 426
              + +   C+ C CD  G + G+  C+  TGQC CK  V G RC+ C+P    LT  N Q
Sbjct: 839  NNSFL---CLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQ 895

Query: 427  GCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAP-YHWKLASGQGCEPCACDP 485
             C  C+C+ LG+     CD  SG+CLC+PN  G +C+QC P ++    +  GC PC+C  
Sbjct: 896  HCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHT 955

Query: 486  HNSLSPQCNQFTGQCPCRE-GFGGLMCSAAAIRQCPDRTYG-DVATG-CRACDCDFRGTE 542
              +++  CN  TGQC C++    G  C      QC D  +G D  TG C+ C+C   G  
Sbjct: 956  TGAVNHICNSLTGQCVCQDASIAGQRCD-----QCKDHYFGFDPQTGRCQPCNCHLSGAL 1010

Query: 543  GPGCDKASGRCLCRPGLTGPRCDQC 567
               C   +G+C C+  +TG +CD C
Sbjct: 1011 NETCHLVTGQCFCKQFVTGSKCDAC 1035



 Score =  165 bits (418), Expect = 2e-40
 Identities = 101/339 (29%), Positives = 153/339 (45%), Gaps = 36/339 (10%)

Query: 257  DRCAP----KPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHE 312
            D C+P      G   G  T  Q    C C+ N  G  C+ C     N  ++     +   
Sbjct: 689  DGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHC-----NFGFKFLRSFNDVG 743

Query: 313  CQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASI 372
            C+ C CN H     F           + G C+ C+   +G  C+ C+ +++     G  +
Sbjct: 744  CEPCQCNLHGSVNKFC--------NPHSGQCE-CKKEAKGLQCDTCRENFY-----GLDV 789

Query: 373  QETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCD 432
               C +C+CD  G++PG  C+  TGQC+CK +V+G +C+ C  G   L   N   C  C+
Sbjct: 790  TN-CKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCN 848

Query: 433  CNILGS-RRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLA--SGQGCEPCACDPHNSL 489
            C+  G+    + C++ +G+C C   V G +C+QC P+ + L   + Q C+ C CD   +L
Sbjct: 849  CDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTL 908

Query: 490  SPQ-CNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDV--ATGCRACDCDFRGTEGPGC 546
                C+  +GQC C     G  C+     QC    Y     ATGC  C C   G     C
Sbjct: 909  PGTICDPISGQCLCVPNRQGRRCN-----QCQPGFYISPGNATGCLPCSCHTTGAVNHIC 963

Query: 547  DKASGRCLCRPG-LTGPRCDQCQRGYCNRYPVCVACHPC 584
            +  +G+C+C+   + G RCDQC+  Y    P    C PC
Sbjct: 964  NSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPC 1002



 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 60/199 (30%), Positives = 90/199 (45%), Gaps = 39/199 (19%)

Query: 279  CVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGA 338
            C C+    G  C +C P   N         +   CQ C+C+               S G 
Sbjct: 868  CPCKLGVTGLRCNQCEPHRYNLTI-----DNFQHCQMCECD---------------SLGT 907

Query: 339  YGG-VCDN------CRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAP 391
              G +CD       C  + +G+ C +CQ  ++ +  PG +    C+ C C   GAV    
Sbjct: 908  LPGTICDPISGQCLCVPNRQGRRCNQCQPGFYIS--PGNATG--CLPCSCHTTGAVNHI- 962

Query: 392  CDPVTGQCVCKE-HVQGERCDLCKPGFTGLTYANPQG--CHRCDCNILGSRRDMPCDEES 448
            C+ +TGQCVC++  + G+RCD CK  + G    +PQ   C  C+C++ G+  +  C   +
Sbjct: 963  CNSLTGQCVCQDASIAGQRCDQCKDHYFGF---DPQTGRCQPCNCHLSGALNET-CHLVT 1018

Query: 449  GRCLCLPNVVGPKCDQCAP 467
            G+C C   V G KCD C P
Sbjct: 1019 GQCFCKQFVTGSKCDACVP 1037



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 52/182 (28%), Positives = 73/182 (40%), Gaps = 40/182 (21%)

Query: 257  DRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRC 316
            D     PG    P     +   C+C  N  G  C +C P +   P       +A  C  C
Sbjct: 903  DSLGTLPGTICDP-----ISGQCLCVPNRQGRRCNQCQPGFYISPG------NATGCLPC 951

Query: 317  DCNGHSETCHFDPAVFAASQGAYGGVCDN------CRDHT-EGKNCERCQLHYFRNRRPG 369
             C+               + GA   +C++      C+D +  G+ C++C+ HYF     G
Sbjct: 952  SCH---------------TTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYF-----G 991

Query: 370  ASIQE-TCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGC 428
               Q   C  C C   GA+    C  VTGQC CK+ V G +CD C P  + L   N  GC
Sbjct: 992  FDPQTGRCQPCNCHLSGAL-NETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGC 1050

Query: 429  HR 430
             +
Sbjct: 1051 SK 1052


>gi|145309326 laminin, gamma 1 precursor [Homo sapiens]
          Length = 1609

 Score =  276 bits (707), Expect = 6e-74
 Identities = 161/467 (34%), Positives = 237/467 (50%), Gaps = 48/467 (10%)

Query: 43  ASSTCGLTKPETYCTQYGEWQM--KCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQND 100
           A++TCG T PE YC Q G   +   C  CD+ QPH  +        ++     WWQSQ  
Sbjct: 65  ATNTCG-TPPEEYCVQTGVTGVTKSCHLCDAGQPHLQHGAAFLTDYNNQADTTWWQSQTM 123

Query: 101 V------NPVSLQLDLDRRFQLQEVMMEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCT 154
           +      + ++L L L + F +  V ++F    P    I + +     W  YQY +  C 
Sbjct: 124 LAGVQYPSSINLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSGSCE 183

Query: 155 STFPRVRQGRPQSWQDVRCQSLPQRPN--ARLNGGKVQLNLMDLVSGIPAT----QSQKI 208
           +T+ +  +G  ++  D +        +  + L GG V  + ++   G P+      S  +
Sbjct: 184 NTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLE---GRPSAYNFDNSPVL 240

Query: 209 QEVGEITNLRVNFTRLAPVPQRGYHPP----SAYYAVSQLRLQGSCFCHGHADRCAPKPG 264
           QE    T++RV   RL       ++ P    S YYA+S   + G C C+GHA  C     
Sbjct: 241 QEWVTATDIRVTLNRLNTFGDEVFNDPKVLKSYYYAISDFAVGGRCKCNGHASECMKNEF 300

Query: 265 ASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSET 324
                        VC C+HNT G +CE+C PF+N+RPWR A  + A EC  CDCNG S+ 
Sbjct: 301 DKL----------VCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQE 350

Query: 325 CHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPD 384
           C+FDP ++ ++   +GG C NC+D+T+G +CERC+ ++FR         E C SC C P 
Sbjct: 351 CYFDPELYRST--GHGGHCTNCQDNTDGAHCERCRENFFR-----LGNNEACSSCHCSPV 403

Query: 385 GAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPC 444
           G++    CD   G+C CK  V G++CD C+PGF  LT A   GC  C C+  GS  +  C
Sbjct: 404 GSL-STQCDSY-GRCSCKPGVMGDKCDRCQPGFHSLTEA---GCRPCSCDPSGSIDE--C 456

Query: 445 DEESGRCLCLPNVVGPKCDQCAPYHWKLASG--QGCEPCACDPHNSL 489
           + E+GRC+C  NV G  C++C P  + L S   +GC PC C  H+S+
Sbjct: 457 NIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCFGHSSV 503



 Score =  253 bits (647), Expect = 6e-67
 Identities = 228/943 (24%), Positives = 387/943 (41%), Gaps = 108/943 (11%)

Query: 250  CFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQD 309
            C C+GH++ C P+ G             VC C+ NTAGP+CE+C+  Y    +  +    
Sbjct: 724  CACNGHSETCDPETG-------------VCNCRDNTAGPHCEKCSDGY----YGDSTAGT 766

Query: 310  AHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPG 369
            + +CQ C C G S +C   P            VC NC   T GK CE C   YF +    
Sbjct: 767  SSDCQPCPCPGGS-SCAVVPKTKEV-------VCTNCPTGTTGKRCELCDDGYFGDPLGR 818

Query: 370  ASIQETCISCECDPDGAVPGAP--CDPVTGQCV-CKEHVQGERCDLCKPGFTGLTYA-NP 425
                  C  C+C  D   P A   C+ +TG+C+ C  +  G  CD CK GF G   A NP
Sbjct: 819  NGPVRLCRLCQCS-DNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNP 877

Query: 426  QG-CHRCDCNILGS-RRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCAC 483
               C  C+CN+ G+ ++   C+  +G+C CLP+V G  C  C P  + L SGQGCE C C
Sbjct: 878  ADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQGCERCDC 937

Query: 484  DPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEG 543
                S + QC+  TGQC C+ G  G  C      +C    +G    GC+ CDC   G+  
Sbjct: 938  HALGSTNGQCDIRTGQCECQPGITGQHC-----ERCEVNHFGFGPEGCKPCDCHPEGSLS 992

Query: 544  PGCDKASGRCLCRPGLTGPRCDQCQRGY-CNR-YPVCVACHPCFQTYDADLREQALRFGR 601
              C K  GRC CR G  G RCDQC+  Y  NR +P C  C  C++     + +  ++   
Sbjct: 993  LQC-KDDGRCECREGFVGNRCDQCEENYFYNRSWPGCQECPACYRLVKDKVADHRVKLQE 1051

Query: 602  LRNATASLWSGPGL-EDRGLASRILDAKSKI-EQIRAVLSSPAVTEQEVAQVASAILSLR 659
            L +  A+L +G  +  D+    R+ +A+ ++ + +R       V +  + ++     +L 
Sbjct: 1052 LESLIANLGTGDEMVTDQAFEDRLKEAEREVMDLLREAQDVKDVDQNLMDRLQRVNNTLS 1111

Query: 660  RTLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQ----------FEKISSA 709
              +  LQ      EET +L     +   +   L+ +  R+ E+           +  S+ 
Sbjct: 1112 SQISRLQNIRNTIEETGNLAEQARAHVENTERLIEIASRELEKAKVAAANVSVTQPESTG 1171

Query: 710  DPSGAFRMLSTAYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVA 769
            DP+    +   A + + +  Q+  D  R+     D+  EA  L+ +   G    + ++  
Sbjct: 1172 DPNNMTLLAEEARKLAERHKQEADDIVRVAKTANDTSTEAYNLLLRTLAGENQTAFEIEE 1231

Query: 770  LRLEMSSLPDLTPTFNKLCGNSRQ-------MACTPISCPGELCPQDNGTACGSRCRGVL 822
            L  +     +++    K      +        A    +   +L P D+ T   +    + 
Sbjct: 1232 LNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVAQLSPLDSET-LENEANNIK 1290

Query: 823  PRAGGAFLMAGQVAEQLRGFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQME 882
              A     +  Q  +        ++     ++   E     Q +A +L  +  A+++  E
Sbjct: 1291 MEAENLEQLIDQKLKDYEDLREDMRGKELEVKNLLEKGKTEQQTADQLLARADAAKALAE 1350

Query: 883  EDVRRTRLLIQQVRDFLTDPDTDAATIQEVSEAVLALWLPTDSATVLQK-MNEIQAIAAR 941
            E  ++ R  +Q+  D L +       +++    V       D+ T  ++ + +I AI   
Sbjct: 1351 EAAKKGRDTLQEANDILNN-------LKDFDRRV------NDNKTAAEEALRKIPAINQT 1397

Query: 942  LPNVDLVLSQTKQDIARARRLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTM 1001
            +   +    + +Q +  A    A+A EA+++AH  E          R  +   + A  T 
Sbjct: 1398 ITEANEKTREAQQALGSA---AADATEAKNKAHEAE----------RIASAVQKNATSTK 1444

Query: 1002 QGTSRSLRLIQDRVAEVQQVLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQ 1061
                R+   + D            +  V +M KQL +    ++  +  A Q    A  A 
Sbjct: 1445 AEAERTFAEVTD-----------LDNEVNNMLKQLQEAEKELKRKQDDADQDMMMAGMAS 1493

Query: 1062 QLAEGASEQALSAQEGFERIKQKYAELKDRLGQ-----SSMLGEQGARIQSVKTEAEELF 1116
            Q A+ A   A  A+     +     +L ++LGQ      + L E    +   K E     
Sbjct: 1494 QAAQEAEINARKAKNSVTSLLSIINDLLEQLGQLDTVDLNKLNEIEGTLNKAKDEM---- 1549

Query: 1117 GETMEMMDRMKDMELELLRGSQAIMLRSADLTGLEKRVEQIRD 1159
             +  ++  ++ D+E E  +   AIM  + D+  + K +  + D
Sbjct: 1550 -KVSDLDRKVSDLENEAKKQEAAIMDYNRDIEEIMKDIRNLED 1591



 Score =  103 bits (258), Expect = 7e-22
 Identities = 62/201 (30%), Positives = 89/201 (44%), Gaps = 23/201 (11%)

Query: 399 CVCKEHVQGERCDLCKPGFTG-----LTYANPQGCHRCDCNILGSRRDMPCDEE------ 447
           C CK +  G  C+ C P F        T  +   C  CDCN  G  ++   D E      
Sbjct: 305 CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCN--GRSQECYFDPELYRSTG 362

Query: 448 -SGRCL-CLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREG 505
             G C  C  N  G  C++C    ++L + + C  C C P  SLS QC+ + G+C C+ G
Sbjct: 363 HGGHCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCSPVGSLSTQCDSY-GRCSCKPG 421

Query: 506 FGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCD 565
             G  C      +C    +     GCR C CD  G+    C+  +GRC+C+  + G  C+
Sbjct: 422 VMGDKCD-----RCQPGFHSLTEAGCRPCSCDPSGSIDE-CNIETGRCVCKDNVEGFNCE 475

Query: 566 QCQRGYCN-RYPVCVACHPCF 585
           +C+ G+ N        C PCF
Sbjct: 476 RCKPGFFNLESSNPRGCTPCF 496



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 31/97 (31%), Positives = 39/97 (40%), Gaps = 25/97 (25%)

Query: 248 GSCFCH-----GHADRCAP----------KPGASAGPSTAVQVHDV----CVCQHNTAGP 288
           G C C         DRC P          +P  S  PS ++   ++    CVC+ N  G 
Sbjct: 414 GRCSCKPGVMGDKCDRCQPGFHSLTEAGCRP-CSCDPSGSIDECNIETGRCVCKDNVEGF 472

Query: 289 NCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETC 325
           NCERC P + N      E  +   C  C C GHS  C
Sbjct: 473 NCERCKPGFFN-----LESSNPRGCTPCFCFGHSSVC 504


>gi|38045910 laminin alpha 3 subunit isoform 1 [Homo sapiens]
          Length = 3333

 Score =  269 bits (688), Expect = 1e-71
 Identities = 186/593 (31%), Positives = 262/593 (44%), Gaps = 97/593 (16%)

Query: 43  ASSTCG-------LTKPETYCTQYG-----------EWQMKCCKCDSRQPHNYYSHRVEN 84
           A++TCG         +PE YC   G           + Q  C  C+S  P    +H V N
Sbjct: 62  ATATCGERGPGEGRPQPELYCKLVGGPTAPGSGHTIQGQF-CDYCNSEDPRK--AHPVTN 118

Query: 85  VASSSGPMRWWQSQ-----NDVNPVSLQLDLDRRFQLQEVMMEF-QGPMPAGMLIERSSD 138
                G  RWWQS         N V+L LDL + F +  ++++F   P P   ++ERS D
Sbjct: 119 AID--GSERWWQSPPLSSGTQYNRVNLTLDLGQLFHVAYILIKFANSPRPDLWVLERSVD 176

Query: 139 FGKTWRVYQYLA---ADCTSTFPRVRQGRPQSWQDVRCQSLPQRPNARLNGGKVQLNLMD 195
           FG T+  +QY A    DC   F R          DV C +   R     NG  V    + 
Sbjct: 177 FGSTYSPWQYFAHSKVDCLKEFGREANMAVTRDDDVLCVTEYSRIVPLENGEVV----VS 232

Query: 196 LVSGIPA----TQSQKIQEVGEITNLRVNFTR----LAPVPQRGYHPPSA----YYAVSQ 243
           L++G P     T S  ++E  + TN+R+ F R    L  +  +    P+     YY++  
Sbjct: 233 LINGRPGAKNFTFSHTLREFTKATNIRLRFLRTNTLLGHLISKAQRDPTVTRRYYYSIKD 292

Query: 244 LRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWR 303
           + + G C C+GHA+ C         P    +    C CQH+T G  C+RC   YN R WR
Sbjct: 293 ISIGGQCVCNGHAEVCNIN-----NPEKLFR----CECQHHTCGETCDRCCTGYNQRRWR 343

Query: 304 PAEGQDAHECQRCDCNGHSETCHFDPAV-----FAASQGAY--GGVCDNCRDHTEGKNCE 356
           PA  + +HEC+ C+C+GH+  C++DP V        +QG Y  GGVC NC+ +T G NCE
Sbjct: 344 PAAWEQSHECEACNCHGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCE 403

Query: 357 RCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPG 416
           +C   Y+R         + CI C CDP+ A     C+  +G+C CK +  G+ C+ C  G
Sbjct: 404 QCAKGYYRPYGVPVDAPDGCIPCSCDPEHA---DGCEQGSGRCHCKPNFHGDNCEKCAIG 460

Query: 417 FTGLTY---------ANPQG-------CHRCDCNILGSRRDMPCDEESGRCLCLPNVVGP 460
           +    +         + P            CDCN+ G   ++ CD   GRCLC P V GP
Sbjct: 461 YYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDCNLEGVLPEI-CDAH-GRCLCRPGVEGP 518

Query: 461 KCDQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCP 520
           +CD C    +       C+ C C    S    C+  TGQC CR G  G  C      +C 
Sbjct: 519 RCDTCRSGFYSFPI---CQACWCSALGSYQMPCSSVTGQCECRPGVTGQRCD-----RCL 570

Query: 521 DRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCN 573
              Y        +  CD  GT     +   G C C+  + GP C +C+  Y N
Sbjct: 571 SGAYDFPHCQGSSSACDPAGT----INSNLGYCQCKLHVEGPTCSRCKLLYWN 619



 Score =  124 bits (311), Expect = 5e-28
 Identities = 67/215 (31%), Positives = 97/215 (45%), Gaps = 27/215 (12%)

Query: 377  ISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNIL 436
            + CEC P GA  G  C P  GQC C+ +V G +C  C  G  G     P  C R      
Sbjct: 1264 LPCECHPTGAT-GPHCSPEGGQCPCQPNVIGRQCTRCATGHYGFPRCKPCSCGR------ 1316

Query: 437  GSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLS---PQC 493
                   C+E +G+C C P  V P+C+ C  + +      GCE C C    ++    P+C
Sbjct: 1317 -----RLCEEMTGQCRCPPRTVRPQCEVCETHSFSFHPMAGCEGCNCSRRGTIEAAMPEC 1371

Query: 494  NQFTGQCPCREGFGGLMCS--AAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASG 551
            ++ +GQC C+    G  C   A+   + P+         C  C+C+  GTE   CD  +G
Sbjct: 1372 DRDSGQCRCKPRITGRQCDRCASGFYRFPE---------CVPCNCNRDGTEPGVCDPGTG 1422

Query: 552  RCLCRPGLTGPRCDQCQRGYCNRYPVCV-ACHPCF 585
             CLC+  + G  C+ C+ G  +  P  +  C  CF
Sbjct: 1423 ACLCKENVEGTECNVCREGSFHLDPANLKGCTSCF 1457



 Score =  105 bits (263), Expect = 2e-22
 Identities = 72/221 (32%), Positives = 90/221 (40%), Gaps = 42/221 (19%)

Query: 276 HDVCVCQHNTAGPNCERCAPFYNNRP-----WRPAEGQDAHEC---------------QR 315
           H  C+C+    GP C+ C   + + P     W  A G     C               QR
Sbjct: 506 HGRCLCRPGVEGPRCDTCRSGFYSFPICQACWCSALGSYQMPCSSVTGQCECRPGVTGQR 565

Query: 316 CD-----------CNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFR 364
           CD           C G S  C  DPA    S   Y   C  C+ H EG  C RC+L Y+ 
Sbjct: 566 CDRCLSGAYDFPHCQGSSSAC--DPAGTINSNLGY---CQ-CKLHVEGPTCSRCKLLYWN 619

Query: 365 NRRPGASIQETCISCECDPDGAVPGA-PCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYA 423
             +   S    C  C+C   G V G   C    G C CK HV G+ CD C+ G+  L  +
Sbjct: 620 LDKENPS---GCSECKCHKAGTVSGTGECRQGDGDCHCKSHVGGDSCDTCEDGYFALEKS 676

Query: 424 NPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQ 464
           N  GC  C C+I G+   M C   SG C C  +VVG  C +
Sbjct: 677 NYFGCQGCQCDIGGALSSM-CSGPSGVCQCREHVVGKVCQR 716



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 74/237 (31%), Positives = 95/237 (40%), Gaps = 40/237 (16%)

Query: 251  FCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDA 310
            F H  A  C   P  + GP  + +    C CQ N  G  C RCA  +   P         
Sbjct: 1258 FYHKGALPCECHPTGATGPHCSPEGGQ-CPCQPNVIGRQCTRCATGHYGFP--------- 1307

Query: 311  HECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGA 370
              C+ C C      C               G C  C   T    CE C+ H F +  P A
Sbjct: 1308 -RCKPCSCG--RRLCE-----------EMTGQC-RCPPRTVRPQCEVCETHSF-SFHPMA 1351

Query: 371  SIQETCISCECDPDGAVPGA--PCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGC 428
                 C  C C   G +  A   CD  +GQC CK  + G +CD C  GF    Y  P+ C
Sbjct: 1352 G----CEGCNCSRRGTIEAAMPECDRDSGQCRCKPRITGRQCDRCASGF----YRFPE-C 1402

Query: 429  HRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQC--APYHWKLASGQGCEPCAC 483
              C+CN  G+   + CD  +G CLC  NV G +C+ C    +H   A+ +GC  C C
Sbjct: 1403 VPCNCNRDGTEPGV-CDPGTGACLCKENVEGTECNVCREGSFHLDPANLKGCTSCFC 1458



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 60/197 (30%), Positives = 87/197 (44%), Gaps = 34/197 (17%)

Query: 277  DVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQ 336
            ++C C    AG +C+ C+P Y    +R  +G     C  C+CNGHS  C           
Sbjct: 1652 EICACPPAYAGDSCQGCSPGY----YRDHKGLYTGRCVPCNCNGHSNQCQDG-------- 1699

Query: 337  GAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCEC-DPDGAVPGAPCDPV 395
                G+C NC+ +T G++CERCQ  Y+     G ++  +C +C C   +    G   +  
Sbjct: 1700 ---SGICVNCQHNTAGEHCERCQEGYY-----GNAVHGSCRACPCPHTNSFATGCVVNGG 1751

Query: 396  TGQCVCKEHVQGERCDLCKPGFTGLTYANPQ----GCHRCDCNILGSRRDMPCDEESGRC 451
              +C CK    G +C+ C PG+ G    NPQ     C  C CN  G      C   +G C
Sbjct: 1752 DVRCSCKAGYTGTQCERCAPGYFG----NPQKFGGSCQPCSCNSNGQLGS--CHPLTGDC 1805

Query: 452  LCL-PNVVGP--KCDQC 465
            +   P    P  +CD C
Sbjct: 1806 INQEPKDSSPAEECDDC 1822



 Score = 84.3 bits (207), Expect = 6e-16
 Identities = 150/716 (20%), Positives = 272/716 (37%), Gaps = 85/716 (11%)

Query: 451  CLCLPNVVGPKCDQCAPYHWK----LASGQGCEPCACDPHNSLSPQCNQFTGQCP-CREG 505
            C C P   G  C  C+P +++    L +G+ C PC C+ H++   QC   +G C  C+  
Sbjct: 1654 CACPPAYAGDSCQGCSPGYYRDHKGLYTGR-CVPCNCNGHSN---QCQDGSGICVNCQHN 1709

Query: 506  FGGLMCSAAAIRQCPDRTYGDVATG-CRACDCDFRGTEGPGCDKASG--RCLCRPGLTGP 562
              G  C      +C +  YG+   G CRAC C    +   GC    G  RC C+ G TG 
Sbjct: 1710 TAGEHCE-----RCQEGYYGNAVHGSCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGT 1764

Query: 563  RCDQCQRGYC-NRYPVCVACHPCFQTYDADLREQALRFGRLRNATASLWSGPGLEDRGLA 621
            +C++C  GY  N      +C PC                   N+   L S   L    + 
Sbjct: 1765 QCERCAPGYFGNPQKFGGSCQPC-----------------SCNSNGQLGSCHPLTGDCIN 1807

Query: 622  SRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRRTLQGLQLDLPLEEETLSL--- 678
                D+ S  E+     S       ++A +   +  ++  LQGL     L E+   +   
Sbjct: 1808 QEPKDS-SPAEECDDCDSCVMTLLNDLATMGEQLRLVKSQLQGLSASAGLLEQMRHMETQ 1866

Query: 679  PRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLSTAYEQSAQAAQ-------Q 731
             +DL +   ++   ++ +  K E  E+    D +  F  L    + +++ AQ       +
Sbjct: 1867 AKDLRNQLLNYRSAISNHGSKIEGLER-ELTDLNQEFETLQEKAQVNSRKAQTLNNNVNR 1925

Query: 732  VSDSSRLLD-QLRDSRREAERLVRQAGGGGGTGS--PKLVALRLEMSSLPDLTPTFNKLC 788
             + S++ LD ++++  R    L++Q  G  G G+  P     R    +   +    N+  
Sbjct: 1926 ATQSAKELDVKIKNVIRNVHILLKQISGTDGEGNNVPSGDFSREWAEAQRMMRELRNRNF 1985

Query: 789  GNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLRGFNAQLQR 848
            G   + A        E   +++               G    +A  + + L  + A+L  
Sbjct: 1986 GKHLREA--------EADKRESQLLLNRIRTWQKTHQGENNGLANSIRDSLNEYEAKLSD 2037

Query: 849  TRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLTDPDTDAAT 908
             R  ++ A   A Q     Q  E  + A + Q++E       L      +LT  D+    
Sbjct: 2038 LRARLQEAAAQAKQANGLNQENERALGAIQRQVKE----INSLQSDFTKYLTTADS---- 2089

Query: 909  IQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARARRLQAEAEE 968
               + +  +AL L   S        E + +AA L      LS   ++++R+    +  EE
Sbjct: 2090 --SLLQTNIALQLMEKS------QKEYEKLAASLNEARQELSDKVRELSRSAGKTSLVEE 2141

Query: 969  ARSRAHAVE---GQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQVLRPA 1025
            A   A +++    Q+E++  N   G   ++ A D        L  I+       +    +
Sbjct: 2142 AEKHARSLQELAKQLEEIKRN-ASGDELVRCAVDAATAYENILNAIKAAEDAANRAASAS 2200

Query: 1026 EKLVTSMTKQ-----LGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALS-AQEGFE 1079
            E  + ++ K+          +  ++L ++A+    +  Q    A    +Q L+      E
Sbjct: 2201 ESALQTVIKEDLPRKAKTLSSNSDKLLNEAKMTQKKLKQEVSPALNNLQQTLNIVTVQKE 2260

Query: 1080 RIKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLR 1135
             I      L+D L      G+  A I S K+   +    T E++D +  ++ ++ R
Sbjct: 2261 VIDTNLTTLRDGL-HGIQRGDIDAMISSAKSMVRKANDITDEVLDGLNPIQTDVER 2315



 Score = 80.5 bits (197), Expect = 9e-15
 Identities = 45/147 (30%), Positives = 61/147 (41%), Gaps = 41/147 (27%)

Query: 476  QGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIR------------------ 517
            +G  PC C P  +  P C+   GQCPC+    G  C+  A                    
Sbjct: 1261 KGALPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHYGFPRCKPCSCGRRLCE 1320

Query: 518  ------QCPDRTYGDVA-------------TGCRACDCDFRGT---EGPGCDKASGRCLC 555
                  +CP RT                   GC  C+C  RGT     P CD+ SG+C C
Sbjct: 1321 EMTGQCRCPPRTVRPQCEVCETHSFSFHPMAGCEGCNCSRRGTIEAAMPECDRDSGQCRC 1380

Query: 556  RPGLTGPRCDQCQRGYCNRYPVCVACH 582
            +P +TG +CD+C  G+  R+P CV C+
Sbjct: 1381 KPRITGRQCDRCASGF-YRFPECVPCN 1406



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 54/170 (31%), Positives = 73/170 (42%), Gaps = 40/170 (23%)

Query: 250  CFCHGHADRCAPKPGASAGPSTAVQVHDVCV-CQHNTAGPNCERCAPFYNNRPWRPAEGQ 308
            C C+GH+++C    G             +CV CQHNTAG +CERC   Y         G 
Sbjct: 1687 CNCNGHSNQCQDGSG-------------ICVNCQHNTAGEHCERCQEGY--------YGN 1725

Query: 309  DAH-ECQRCDCNGHSETCHFDPAVFAASQGAYGG-VCDNCRDHTEGKNCERCQLHYFRNR 366
              H  C+ C C  H+ +       FA      GG V  +C+    G  CERC   YF N 
Sbjct: 1726 AVHGSCRACPC-PHTNS-------FATGCVVNGGDVRCSCKAGYTGTQCERCAPGYFGNP 1777

Query: 367  RPGASIQETCISCECDPDGAVPGAPCDPVTGQCV---CKEHVQGERCDLC 413
            +       +C  C C+ +G +    C P+TG C+    K+    E CD C
Sbjct: 1778 Q---KFGGSCQPCSCNSNGQL--GSCHPLTGDCINQEPKDSSPAEECDDC 1822



 Score = 70.5 bits (171), Expect = 9e-12
 Identities = 45/160 (28%), Positives = 68/160 (42%), Gaps = 15/160 (9%)

Query: 346  CRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCV-CKEH 404
            C     G +C+ C   Y+R+ +        C+ C C+         C   +G CV C+ +
Sbjct: 1656 CPPAYAGDSCQGCSPGYYRDHK--GLYTGRCVPCNCNGHSN----QCQDGSGICVNCQHN 1709

Query: 405  VQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESG--RCLCLPNVVGPKC 462
              GE C+ C+ G+ G   A    C  C C    S     C    G  RC C     G +C
Sbjct: 1710 TAGEHCERCQEGYYG--NAVHGSCRACPCPHTNSFAT-GCVVNGGDVRCSCKAGYTGTQC 1766

Query: 463  DQCAPYHW--KLASGQGCEPCACDPHNSLSPQCNQFTGQC 500
            ++CAP ++      G  C+PC+C+ +  L   C+  TG C
Sbjct: 1767 ERCAPGYFGNPQKFGGSCQPCSCNSNGQLG-SCHPLTGDC 1805



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 31/114 (27%), Positives = 45/114 (39%), Gaps = 22/114 (19%)

Query: 250 CFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQD 309
           C CH        K G  +G     Q    C C+ +  G +C+ C   Y        E  +
Sbjct: 631 CKCH--------KAGTVSGTGECRQGDGDCHCKSHVGGDSCDTCEDGYF-----ALEKSN 677

Query: 310 AHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYF 363
              CQ C C+          A+ +   G   GVC  CR+H  GK C+R + +Y+
Sbjct: 678 YFGCQGCQCD-------IGGALSSMCSGP-SGVCQ-CREHVVGKVCQRPENNYY 722


>gi|189217425 laminin alpha 3 subunit isoform 3 [Homo sapiens]
          Length = 3277

 Score =  269 bits (688), Expect = 1e-71
 Identities = 186/593 (31%), Positives = 262/593 (44%), Gaps = 97/593 (16%)

Query: 43  ASSTCG-------LTKPETYCTQYG-----------EWQMKCCKCDSRQPHNYYSHRVEN 84
           A++TCG         +PE YC   G           + Q  C  C+S  P    +H V N
Sbjct: 62  ATATCGERGPGEGRPQPELYCKLVGGPTAPGSGHTIQGQF-CDYCNSEDPRK--AHPVTN 118

Query: 85  VASSSGPMRWWQSQ-----NDVNPVSLQLDLDRRFQLQEVMMEF-QGPMPAGMLIERSSD 138
                G  RWWQS         N V+L LDL + F +  ++++F   P P   ++ERS D
Sbjct: 119 AID--GSERWWQSPPLSSGTQYNRVNLTLDLGQLFHVAYILIKFANSPRPDLWVLERSVD 176

Query: 139 FGKTWRVYQYLA---ADCTSTFPRVRQGRPQSWQDVRCQSLPQRPNARLNGGKVQLNLMD 195
           FG T+  +QY A    DC   F R          DV C +   R     NG  V    + 
Sbjct: 177 FGSTYSPWQYFAHSKVDCLKEFGREANMAVTRDDDVLCVTEYSRIVPLENGEVV----VS 232

Query: 196 LVSGIPA----TQSQKIQEVGEITNLRVNFTR----LAPVPQRGYHPPSA----YYAVSQ 243
           L++G P     T S  ++E  + TN+R+ F R    L  +  +    P+     YY++  
Sbjct: 233 LINGRPGAKNFTFSHTLREFTKATNIRLRFLRTNTLLGHLISKAQRDPTVTRRYYYSIKD 292

Query: 244 LRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWR 303
           + + G C C+GHA+ C         P    +    C CQH+T G  C+RC   YN R WR
Sbjct: 293 ISIGGQCVCNGHAEVCNIN-----NPEKLFR----CECQHHTCGETCDRCCTGYNQRRWR 343

Query: 304 PAEGQDAHECQRCDCNGHSETCHFDPAV-----FAASQGAY--GGVCDNCRDHTEGKNCE 356
           PA  + +HEC+ C+C+GH+  C++DP V        +QG Y  GGVC NC+ +T G NCE
Sbjct: 344 PAAWEQSHECEACNCHGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCE 403

Query: 357 RCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPG 416
           +C   Y+R         + CI C CDP+ A     C+  +G+C CK +  G+ C+ C  G
Sbjct: 404 QCAKGYYRPYGVPVDAPDGCIPCSCDPEHA---DGCEQGSGRCHCKPNFHGDNCEKCAIG 460

Query: 417 FTGLTY---------ANPQG-------CHRCDCNILGSRRDMPCDEESGRCLCLPNVVGP 460
           +    +         + P            CDCN+ G   ++ CD   GRCLC P V GP
Sbjct: 461 YYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDCNLEGVLPEI-CDAH-GRCLCRPGVEGP 518

Query: 461 KCDQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCP 520
           +CD C    +       C+ C C    S    C+  TGQC CR G  G  C      +C 
Sbjct: 519 RCDTCRSGFYSFPI---CQACWCSALGSYQMPCSSVTGQCECRPGVTGQRCD-----RCL 570

Query: 521 DRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCN 573
              Y        +  CD  GT     +   G C C+  + GP C +C+  Y N
Sbjct: 571 SGAYDFPHCQGSSSACDPAGT----INSNLGYCQCKLHVEGPTCSRCKLLYWN 619



 Score =  124 bits (311), Expect = 5e-28
 Identities = 67/215 (31%), Positives = 97/215 (45%), Gaps = 27/215 (12%)

Query: 377  ISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNIL 436
            + CEC P GA  G  C P  GQC C+ +V G +C  C  G  G     P  C R      
Sbjct: 1264 LPCECHPTGAT-GPHCSPEGGQCPCQPNVIGRQCTRCATGHYGFPRCKPCSCGR------ 1316

Query: 437  GSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLS---PQC 493
                   C+E +G+C C P  V P+C+ C  + +      GCE C C    ++    P+C
Sbjct: 1317 -----RLCEEMTGQCRCPPRTVRPQCEVCETHSFSFHPMAGCEGCNCSRRGTIEAAMPEC 1371

Query: 494  NQFTGQCPCREGFGGLMCS--AAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASG 551
            ++ +GQC C+    G  C   A+   + P+         C  C+C+  GTE   CD  +G
Sbjct: 1372 DRDSGQCRCKPRITGRQCDRCASGFYRFPE---------CVPCNCNRDGTEPGVCDPGTG 1422

Query: 552  RCLCRPGLTGPRCDQCQRGYCNRYPVCV-ACHPCF 585
             CLC+  + G  C+ C+ G  +  P  +  C  CF
Sbjct: 1423 ACLCKENVEGTECNVCREGSFHLDPANLKGCTSCF 1457



 Score =  105 bits (263), Expect = 2e-22
 Identities = 72/221 (32%), Positives = 90/221 (40%), Gaps = 42/221 (19%)

Query: 276 HDVCVCQHNTAGPNCERCAPFYNNRP-----WRPAEGQDAHEC---------------QR 315
           H  C+C+    GP C+ C   + + P     W  A G     C               QR
Sbjct: 506 HGRCLCRPGVEGPRCDTCRSGFYSFPICQACWCSALGSYQMPCSSVTGQCECRPGVTGQR 565

Query: 316 CD-----------CNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFR 364
           CD           C G S  C  DPA    S   Y   C  C+ H EG  C RC+L Y+ 
Sbjct: 566 CDRCLSGAYDFPHCQGSSSAC--DPAGTINSNLGY---CQ-CKLHVEGPTCSRCKLLYWN 619

Query: 365 NRRPGASIQETCISCECDPDGAVPGA-PCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYA 423
             +   S    C  C+C   G V G   C    G C CK HV G+ CD C+ G+  L  +
Sbjct: 620 LDKENPS---GCSECKCHKAGTVSGTGECRQGDGDCHCKSHVGGDSCDTCEDGYFALEKS 676

Query: 424 NPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQ 464
           N  GC  C C+I G+   M C   SG C C  +VVG  C +
Sbjct: 677 NYFGCQGCQCDIGGALSSM-CSGPSGVCQCREHVVGKVCQR 716



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 74/237 (31%), Positives = 95/237 (40%), Gaps = 40/237 (16%)

Query: 251  FCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDA 310
            F H  A  C   P  + GP  + +    C CQ N  G  C RCA  +   P         
Sbjct: 1258 FYHKGALPCECHPTGATGPHCSPEGGQ-CPCQPNVIGRQCTRCATGHYGFP--------- 1307

Query: 311  HECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGA 370
              C+ C C      C               G C  C   T    CE C+ H F +  P A
Sbjct: 1308 -RCKPCSCG--RRLCE-----------EMTGQC-RCPPRTVRPQCEVCETHSF-SFHPMA 1351

Query: 371  SIQETCISCECDPDGAVPGA--PCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGC 428
                 C  C C   G +  A   CD  +GQC CK  + G +CD C  GF    Y  P+ C
Sbjct: 1352 G----CEGCNCSRRGTIEAAMPECDRDSGQCRCKPRITGRQCDRCASGF----YRFPE-C 1402

Query: 429  HRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQC--APYHWKLASGQGCEPCAC 483
              C+CN  G+   + CD  +G CLC  NV G +C+ C    +H   A+ +GC  C C
Sbjct: 1403 VPCNCNRDGTEPGV-CDPGTGACLCKENVEGTECNVCREGSFHLDPANLKGCTSCFC 1458



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 60/197 (30%), Positives = 87/197 (44%), Gaps = 34/197 (17%)

Query: 277  DVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQ 336
            ++C C    AG +C+ C+P Y    +R  +G     C  C+CNGHS  C           
Sbjct: 1652 EICACPPAYAGDSCQGCSPGY----YRDHKGLYTGRCVPCNCNGHSNQCQDG-------- 1699

Query: 337  GAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCEC-DPDGAVPGAPCDPV 395
                G+C NC+ +T G++CERCQ  Y+     G ++  +C +C C   +    G   +  
Sbjct: 1700 ---SGICVNCQHNTAGEHCERCQEGYY-----GNAVHGSCRACPCPHTNSFATGCVVNGG 1751

Query: 396  TGQCVCKEHVQGERCDLCKPGFTGLTYANPQ----GCHRCDCNILGSRRDMPCDEESGRC 451
              +C CK    G +C+ C PG+ G    NPQ     C  C CN  G      C   +G C
Sbjct: 1752 DVRCSCKAGYTGTQCERCAPGYFG----NPQKFGGSCQPCSCNSNGQLGS--CHPLTGDC 1805

Query: 452  LCL-PNVVGP--KCDQC 465
            +   P    P  +CD C
Sbjct: 1806 INQEPKDSSPAEECDDC 1822



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 147/693 (21%), Positives = 256/693 (36%), Gaps = 137/693 (19%)

Query: 451  CLCLPNVVGPKCDQCAPYHWK----LASGQGCEPCACDPHNSLSPQCNQFTGQCP-CREG 505
            C C P   G  C  C+P +++    L +G+ C PC C+ H++   QC   +G C  C+  
Sbjct: 1654 CACPPAYAGDSCQGCSPGYYRDHKGLYTGR-CVPCNCNGHSN---QCQDGSGICVNCQHN 1709

Query: 506  FGGLMCSAAAIRQCPDRTYGDVATG-CRACDCDFRGTEGPGCDKASG--RCLCRPGLTGP 562
              G  C      +C +  YG+   G CRAC C    +   GC    G  RC C+ G TG 
Sbjct: 1710 TAGEHCE-----RCQEGYYGNAVHGSCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGT 1764

Query: 563  RCDQCQRGY---------------CNRYPVCVACHP------------------------ 583
            +C++C  GY               CN      +CHP                        
Sbjct: 1765 QCERCAPGYFGNPQKFGGSCQPCSCNSNGQLGSCHPLTGDCINQEPKDSSPAEECDDCDS 1824

Query: 584  CFQTYDADLREQALRFGRLRNATASLWSGPGL--EDRGLASRILDAKSKIEQIRAVLSSP 641
            C  T   DL     +   +++    L +  GL  + R + ++  D ++++   R+ +S+ 
Sbjct: 1825 CVMTLLNDLATMGEQLRLVKSQLQGLSASAGLLEQMRHMETQAKDLRNQLLNYRSAISNH 1884

Query: 642  AVTEQEVAQVASAILSLRRTLQGLQLDL-PLEEETLSLPRDLESLDRSFNGLLTMYQRKR 700
                       S I  L R L  L  +   L+E+     R  ++L+ + N      Q  +
Sbjct: 1885 ----------GSKIEGLERELTDLNQEFETLQEKAQVNSRKAQTLNNNVN---RATQSAK 1931

Query: 701  EQFEKISSADPSGAFRMLSTAYEQSAQA-----AQQVSDS----SRLLDQLRDSRREAER 751
            E   KI +   +         ++++ Q      A  + DS       L  LR   +EA  
Sbjct: 1932 ELDVKIKNVIRNVHMLNRIRTWQKTHQGENNGLANSIRDSLNEYEAKLSDLRARLQEAAA 1991

Query: 752  LVRQAGGGGGTGSPKLVALRLEMSSLPDLTPTFNK-LCGNSRQMACTPISCP-------- 802
              +QA G        L A++ ++  +  L   F K L      +  T I+          
Sbjct: 1992 QAKQANGLNQENERALGAIQRQVKEINSLQSDFTKYLTTADSSLLQTNIALQLMEKSQKE 2051

Query: 803  -GELCPQDNGT--ACGSRCRGVLPRAGGAFLM--AGQVAEQLRGFNAQLQRTR------Q 851
              +L    N        + R +   AG   L+  A + A  L+    QL+  +      +
Sbjct: 2052 YEKLAASLNEARQELSDKVRELSRSAGKTSLVEEAEKHARSLQELAKQLEEIKRNASGDE 2111

Query: 852  MIRAAEESA-------SQIQSSAQRLETQVSASRSQME----EDVRRTRLLIQQVRDFLT 900
            ++R A ++A       + I+++        SAS S ++    ED+ R    +    D L 
Sbjct: 2112 LVRCAVDAATAYENILNAIKAAEDAANRAASASESALQTVIKEDLPRKAKTLSSNSDKLL 2171

Query: 901  DPD--TDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIAR 958
            +    T     QEVS A+  L    +  TV +++            +D  L+  +  +  
Sbjct: 2172 NEAKMTQKKLKQEVSPALNNLQQTLNIVTVQKEV------------IDTNLTTLRDGLHG 2219

Query: 959  ARR--LQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVA 1016
             +R  + A    A+S         ++V+  L      ++  +DT   T            
Sbjct: 2220 IQRGDIDAMISSAKSMVRKANDITDEVLDGLNPIQTDVERIKDTYGRTQNE--------- 2270

Query: 1017 EVQQVLRPAEKLVTSMTKQLGDFWTRMEELRHQ 1049
            + ++ L  A+  V  +T +L D W ++E +  Q
Sbjct: 2271 DFKKALTDADNSVNKLTNKLPDLWRKIESINQQ 2303



 Score = 80.5 bits (197), Expect = 9e-15
 Identities = 45/147 (30%), Positives = 61/147 (41%), Gaps = 41/147 (27%)

Query: 476  QGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIR------------------ 517
            +G  PC C P  +  P C+   GQCPC+    G  C+  A                    
Sbjct: 1261 KGALPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHYGFPRCKPCSCGRRLCE 1320

Query: 518  ------QCPDRTYGDVA-------------TGCRACDCDFRGT---EGPGCDKASGRCLC 555
                  +CP RT                   GC  C+C  RGT     P CD+ SG+C C
Sbjct: 1321 EMTGQCRCPPRTVRPQCEVCETHSFSFHPMAGCEGCNCSRRGTIEAAMPECDRDSGQCRC 1380

Query: 556  RPGLTGPRCDQCQRGYCNRYPVCVACH 582
            +P +TG +CD+C  G+  R+P CV C+
Sbjct: 1381 KPRITGRQCDRCASGF-YRFPECVPCN 1406



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 54/170 (31%), Positives = 73/170 (42%), Gaps = 40/170 (23%)

Query: 250  CFCHGHADRCAPKPGASAGPSTAVQVHDVCV-CQHNTAGPNCERCAPFYNNRPWRPAEGQ 308
            C C+GH+++C    G             +CV CQHNTAG +CERC   Y         G 
Sbjct: 1687 CNCNGHSNQCQDGSG-------------ICVNCQHNTAGEHCERCQEGY--------YGN 1725

Query: 309  DAH-ECQRCDCNGHSETCHFDPAVFAASQGAYGG-VCDNCRDHTEGKNCERCQLHYFRNR 366
              H  C+ C C  H+ +       FA      GG V  +C+    G  CERC   YF N 
Sbjct: 1726 AVHGSCRACPC-PHTNS-------FATGCVVNGGDVRCSCKAGYTGTQCERCAPGYFGNP 1777

Query: 367  RPGASIQETCISCECDPDGAVPGAPCDPVTGQCV---CKEHVQGERCDLC 413
            +       +C  C C+ +G +    C P+TG C+    K+    E CD C
Sbjct: 1778 Q---KFGGSCQPCSCNSNGQL--GSCHPLTGDCINQEPKDSSPAEECDDC 1822



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 31/114 (27%), Positives = 45/114 (39%), Gaps = 22/114 (19%)

Query: 250 CFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQD 309
           C CH        K G  +G     Q    C C+ +  G +C+ C   Y        E  +
Sbjct: 631 CKCH--------KAGTVSGTGECRQGDGDCHCKSHVGGDSCDTCEDGYF-----ALEKSN 677

Query: 310 AHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYF 363
              CQ C C+          A+ +   G   GVC  CR+H  GK C+R + +Y+
Sbjct: 678 YFGCQGCQCD-------IGGALSSMCSGP-SGVCQ-CREHVVGKVCQRPENNYY 722


>gi|110611156 laminin, gamma 3 precursor [Homo sapiens]
          Length = 1575

 Score =  253 bits (647), Expect = 6e-67
 Identities = 169/504 (33%), Positives = 233/504 (46%), Gaps = 59/504 (11%)

Query: 20  ACSRGA-----CYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYGEWQM--KCCKCDSR 72
           AC  GA     C P   +   GR    +AS TCG + PE +C   G       C +CD+ 
Sbjct: 24  ACYDGAGRPQRCLPVFENAAFGR--LAQASHTCG-SPPEDFCPHVGAAGAGAHCQRCDAA 80

Query: 73  QPHNYYSHRVENVASSSGPMRWWQSQNDV------NPVSLQLDLDRRFQLQEVMMEFQGP 126
            P  +++        S     WWQS +          V++ L L + +++  V ++F   
Sbjct: 81  DPQRHHNASYLTDFHSQDESTWWQSPSMAFGVQYPTSVNITLRLGKAYEITYVRLKFHTS 140

Query: 127 MPAGMLIERSSDFGKTWRVYQYLAADCTSTF--PRVRQGRPQSWQDVRCQSLPQRPNARL 184
            P    I + S     W  YQ+ +A C  T+  P  +  RP   + V   +      + L
Sbjct: 141 RPESFAIYKRSRADGPWEPYQFYSASCQKTYGRPEGQYLRPGEDERVAFCTSEFSDISPL 200

Query: 185 NGGKVQLNLMDLVSGIPAT----QSQKIQEVGEITNLRVNFTRLAPVPQRGYHPP----S 236
           +GG V  + ++   G P+     +S  +QE    T L ++  RL       +  P    S
Sbjct: 201 SGGNVAFSTLE---GRPSAYNFEESPGLQEWVTSTELLISLDRLNTFGDDIFKDPKVLQS 257

Query: 237 AYYAVSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPF 296
            YYAVS   + G C C+GHA  C        GP  A Q+   C CQHNT G +CERC PF
Sbjct: 258 YYYAVSDFSVGGRCKCNGHASEC--------GPDVAGQL--ACRCQHNTTGTDCERCLPF 307

Query: 297 YNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCE 356
           + +RPW     + AHEC  C+C+G SE C FD  +F ++   +GG C +CRDHT G +CE
Sbjct: 308 FQDRPWARGTAEAAHECLPCNCSGRSEECTFDRELFRST--GHGGRCHHCRDHTAGPHCE 365

Query: 357 RCQLHYFR--NRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCK 414
           RCQ +++    R P       C  C+C   G++    CD  TG C CK  V G +CD C 
Sbjct: 366 RCQENFYHWDPRMP-------CQPCDCQSAGSL-HLQCDD-TGTCACKPTVTGWKCDRCL 416

Query: 415 PGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLA- 473
           PGF  L+     GC  C CN  GS     CD  SGRC C  NV G  CD+C P  + L  
Sbjct: 417 PGFHSLSEG---GCRPCTCNPAGSLD--TCDPRSGRCPCKENVEGNLCDRCRPGTFNLQP 471

Query: 474 -SGQGCEPCACDPHNSLSPQCNQF 496
            +  GC  C C  H+ +     QF
Sbjct: 472 HNPAGCSSCFCYGHSKVCASTAQF 495



 Score =  197 bits (502), Expect = 4e-50
 Identities = 120/348 (34%), Positives = 156/348 (44%), Gaps = 53/348 (15%)

Query: 250  CFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAP-FYNNRPWRPAEGQ 308
            C C+ H   C P  G             +CVC H+T GP+CERC P FY N    P  GQ
Sbjct: 707  CTCNQHGT-CDPNTG-------------ICVCSHHTEGPSCERCLPGFYGN----PFAGQ 748

Query: 309  DAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRP 368
             A +CQ C C G S  C   P            VC +C     G+ CE C   +F +   
Sbjct: 749  -ADDCQPCPCPGQS-ACTTIPESREV-------VCTHCPPGQRGRRCEVCDDGFFGDPLG 799

Query: 369  GASIQETCISCEC----DPDGAVPGAPCDPVTGQCV-CKEHVQGERCDLCKPGFTGLTYA 423
                 + C  C+C    DP+       CDP++G C+ C  +  G+ C+ C+ GF G   A
Sbjct: 800  LFGHPQPCHQCQCSGNVDPNAV---GNCDPLSGHCLRCLHNTTGDHCEHCQEGFYGSALA 856

Query: 424  NPQG--CHRCDCNILGS-RRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP 480
                  C  C C+  GS    MPCD  +G+C CLP+V    C +C P  + L  G+GC  
Sbjct: 857  PRPADKCMPCSCHPQGSVSEQMPCDPVTGQCSCLPHVTARDCSRCYPGFFDLQPGRGCRS 916

Query: 481  CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG 540
            C C P  S   QC+  TGQC CR G  G  C      +C    +G    GCRAC C   G
Sbjct: 917  CKCHPLGSQEDQCHPKTGQCTCRPGVTGQACD-----RCQLGFFGFSIKGCRACRCSPLG 971

Query: 541  TEGPGCDKASGRCLCRPGLTGPRCDQCQRGY--------CNRYPVCVA 580
                 C + +G C+CRPG  G +CD+C   +        C + P C A
Sbjct: 972  AASAQCHE-NGTCVCRPGFEGYKCDRCHDNFFLTADGTHCQQCPSCYA 1018



 Score =  125 bits (313), Expect = 3e-28
 Identities = 95/333 (28%), Positives = 118/333 (35%), Gaps = 97/333 (29%)

Query: 345 NCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEH 404
           +C     G+ CE C   Y R    G     +C+ C C+  G      CDP TG CVC  H
Sbjct: 674 SCPTGYTGQFCESCAPGYKREMPQGGPYA-SCVPCTCNQHGT-----CDPNTGICVCSHH 727

Query: 405 VQGERCDLCKPGFTGLTYAN------------------------------PQG-----CH 429
            +G  C+ C PGF G  +A                               P G     C 
Sbjct: 728 TEGPSCERCLPGFYGNPFAGQADDCQPCPCPGQSACTTIPESREVVCTHCPPGQRGRRCE 787

Query: 430 RCDCNILGS-----RRDMPC-----------------DEESGRCL-CLPNVVGPKCDQCA 466
            CD    G          PC                 D  SG CL CL N  G  C+ C 
Sbjct: 788 VCDDGFFGDPLGLFGHPQPCHQCQCSGNVDPNAVGNCDPLSGHCLRCLHNTTGDHCEHCQ 847

Query: 467 PYHWKLA----SGQGCEPCACDPHNSLSPQ--CNQFTGQCPCREGFGGLMCSAAAIRQCP 520
              +  A        C PC+C P  S+S Q  C+  TGQC C        CS    R  P
Sbjct: 848 EGFYGSALAPRPADKCMPCSCHPQGSVSEQMPCDPVTGQCSCLPHVTARDCS----RCYP 903

Query: 521 DRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGY--------- 571
                    GCR+C C   G++   C   +G+C CRPG+TG  CD+CQ G+         
Sbjct: 904 GFFDLQPGRGCRSCKCHPLGSQEDQCHPKTGQCTCRPGVTGQACDRCQLGFFGFSIKGCR 963

Query: 572 -------------CNRYPVCVACHPCFQTYDAD 591
                        C+    CV C P F+ Y  D
Sbjct: 964 ACRCSPLGAASAQCHENGTCV-CRPGFEGYKCD 995



 Score =  101 bits (251), Expect = 5e-21
 Identities = 72/222 (32%), Positives = 92/222 (41%), Gaps = 35/222 (15%)

Query: 380 ECDPDGAVPGAPCDPVTGQ--CVCKEHVQGERCDLCKPGFTGLTYAN--PQGCHRC-DCN 434
           EC PD          V GQ  C C+ +  G  C+ C P F    +A    +  H C  CN
Sbjct: 279 ECGPD----------VAGQLACRCQHNTTGTDCERCLPFFQDRPWARGTAEAAHECLPCN 328

Query: 435 ILGSRRDMPCDEE-------SGRCL-CLPNVVGPKCDQCAP--YHWKLASGQGCEPCACD 484
             G   +   D E        GRC  C  +  GP C++C    YHW       C+PC C 
Sbjct: 329 CSGRSEECTFDRELFRSTGHGGRCHHCRDHTAGPHCERCQENFYHWD--PRMPCQPCDCQ 386

Query: 485 PHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGP 544
              SL  QC+  TG C C+    G  C      +C    +     GCR C C+  G+   
Sbjct: 387 SAGSLHLQCDD-TGTCACKPTVTGWKCD-----RCLPGFHSLSEGGCRPCTCNPAGSLDT 440

Query: 545 GCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVA-CHPCF 585
            CD  SGRC C+  + G  CD+C+ G  N  P   A C  CF
Sbjct: 441 -CDPRSGRCPCKENVEGNLCDRCRPGTFNLQPHNPAGCSSCF 481



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 26/87 (29%), Positives = 35/87 (40%), Gaps = 6/87 (6%)

Query: 500 CPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGL 559
           C C  G+ G  C + A     +   G     C  C C+  GT    CD  +G C+C    
Sbjct: 673 CSCPTGYTGQFCESCAPGYKREMPQGGPYASCVPCTCNQHGT----CDPNTGICVCSHHT 728

Query: 560 TGPRCDQCQRGYCNRYPVCVA--CHPC 584
            GP C++C  G+        A  C PC
Sbjct: 729 EGPSCERCLPGFYGNPFAGQADDCQPC 755



 Score = 32.0 bits (71), Expect = 3.5
 Identities = 73/361 (20%), Positives = 139/361 (38%), Gaps = 52/361 (14%)

Query: 821  VLPRAGGAFLMAGQVAEQLRGFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVS---AS 877
            +LP A  AFL      EQ+      ++  R+ ++   + A   Q+ +Q+  TQ++   A 
Sbjct: 1068 LLPGAREAFL------EQMMSLEGAVKAAREQLQRLNKGARCAQAGSQKTCTQLADLEAV 1121

Query: 878  RSQMEEDVRRTRLLIQQVRDFLTDPDTDAATIQEVSEAVLALWLPTDSAT--------VL 929
                EE++     ++  +      P          +EA        D+AT         L
Sbjct: 1122 LESSEEEILHAAAILASLEIPQEGPSQPTKWSHLATEARALARSHRDTATKIAATAWRAL 1181

Query: 930  QKMNEIQAIAARLPNVDLVLSQTKQDIA-RARRLQAEAEEARSRAHAVEGQVEDVVGNLR 988
               N   A+   L    + L +T++D+  R + +QA  +  R+    V  + E V+  ++
Sbjct: 1182 LASNTSYALLWNLLEGRVAL-ETQRDLEDRYQEVQAAQKALRTAVAEVLPEAESVLATVQ 1240

Query: 989  Q------GTVALQEAQDTMQGTSRS------LRLIQDRVAEVQQVLRPAEKLV---TSMT 1033
            Q        +AL  +   +   SR+       + ++  VA  Q +   A + +      T
Sbjct: 1241 QVGADTAPYLALLASPGALPQKSRAEDLGLKAKALEKTVASWQHMATEAARTLQTAAQAT 1300

Query: 1034 KQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFERIKQKYAELKDRLG 1093
             +  +  T++ +    A  Q + +VQA  +    +   L+  EG   +K ++   KD   
Sbjct: 1301 LRQTEPLTKLHQEARAALTQASSSVQAATVTVMGARTLLADLEG---MKLQFPRPKD--- 1354

Query: 1094 QSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAIMLRSADLTGLEKR 1153
                   Q A  +   + ++ L  +T     R K  + E + G+ A +  SA   G E  
Sbjct: 1355 -------QAALQRKADSVSDRLLADT-----RKKTKQAERMLGNAAPLSSSAKKKGREAE 1402

Query: 1154 V 1154
            V
Sbjct: 1403 V 1403


>gi|148613884 netrin 1 [Homo sapiens]
          Length = 604

 Score =  223 bits (569), Expect = 6e-58
 Identities = 134/411 (32%), Positives = 210/411 (51%), Gaps = 39/411 (9%)

Query: 26  CYPPVGDLLVGRTRFLRASSTCGLTKPETYC--TQYGEWQMKCCK-CDSRQPHNYYSHRV 82
           C P   +   G+   +R SSTCG   P  YC  ++ GE +++ C  C++  P   +    
Sbjct: 51  CIPDFVNAAFGKD--VRVSSTCG-RPPARYCVVSERGEERLRSCHLCNASDPKKAHPPAF 107

Query: 83  ENVASSSGPMRWWQSQNDV---NPVSLQLDLDRRFQLQEVMMEFQGPMPAGMLIERSSDF 139
               ++   +  WQS+N +   + V+L L L ++F++  V ++F  P P  M I +S D+
Sbjct: 108 LTDLNNPHNLTCWQSENYLQFPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDY 167

Query: 140 GKTWRVYQYLAADCTSTFPRVRQG--RPQSWQDVRCQS--LPQRPNARLNGGKVQLNLMD 195
           G+TW  +Q+ +  C   + R  +     Q+ Q+  C       RP   L+GG +  + +D
Sbjct: 168 GRTWVPFQFYSTQCRKMYNRPHRAPITKQNEQEAVCTDSHTDMRP---LSGGLIAFSTLD 224

Query: 196 LVSGIPATQ----SQKIQEVGEITNLRVNFTRLAPVPQRGYHPP-----SAYYAVSQLRL 246
              G P+      S  +Q+    T++RV F+RL                S +YAVS L++
Sbjct: 225 ---GRPSAHDFDNSPVLQDWVTATDIRVAFSRLHTFGDENEDDSELARDSYFYAVSDLQV 281

Query: 247 QGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAE 306
            G C C+GHA RC      S           VC C+HNTAGP C+RC PF+ +RPW+ A 
Sbjct: 282 GGRCKCNGHAARCVRDRDDSL----------VCDCRHNTAGPECDRCKPFHYDRPWQRAT 331

Query: 307 GQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNR 366
            ++A+EC  C+CN H+  C F+  ++  S    GGVC NCR +T G++C  C+  Y+R+ 
Sbjct: 332 AREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGYYRDM 391

Query: 367 RPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGF 417
               + ++ C +C+C P GA  G  C+  TGQC CK+ V G  C+ C  G+
Sbjct: 392 GKPITHRKACKACDCHPVGAA-GKTCNQTTGQCPCKDGVTGITCNRCAKGY 441



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 54/182 (29%), Positives = 81/182 (44%), Gaps = 37/182 (20%)

Query: 430 RCDCNILGSR--RDMPCDEESGRCLCLPNVVGPKCDQCAPYH----WKLASGQGCEPCAC 483
           RC CN   +R  RD    ++S  C C  N  GP+CD+C P+H    W+ A+ +    C  
Sbjct: 284 RCKCNGHAARCVRDR---DDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVA 340

Query: 484 DPHNSLSPQCN-----------QFTGQC-PCREGFGGLMCSAAAIRQCPDRTYGDVAT-- 529
              N  + +C            +  G C  CR    G  C       C +  Y D+    
Sbjct: 341 CNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHC-----HYCKEGYYRDMGKPI 395

Query: 530 ----GCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGY-CNRYPVCVACHPC 584
                C+ACDC   G  G  C++ +G+C C+ G+TG  C++C +GY  +R P+     PC
Sbjct: 396 THRKACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIA----PC 451

Query: 585 FQ 586
            +
Sbjct: 452 IK 453


>gi|38788416 laminin, alpha 1 precursor [Homo sapiens]
          Length = 3075

 Score =  213 bits (541), Expect = 1e-54
 Identities = 153/528 (28%), Positives = 229/528 (43%), Gaps = 90/528 (17%)

Query: 14  LLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYGEW------QMKCC 67
           LL     C +   +P +  L +     +  ++TCG   PE +C              +C 
Sbjct: 10  LLCVAAQCRQRGLFPAI--LNLASNAHISTNATCGEKGPEMFCKLVEHVPGRPVRNPQCR 67

Query: 68  KCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNP-----VSLQLDLDRRFQLQEVMME 122
            CD    +    H + +     G   WWQS +  N      V++ LDL + FQ+  V+++
Sbjct: 68  ICDGNSANPRERHPISHAID--GTNNWWQSPSIQNGREYHWVTITLDLRQVFQVAYVIIK 125

Query: 123 F-QGPMPAGMLIERSSDFGKTWRVYQYLA---ADCTSTFPRVRQGRPQSWQ---DVRCQS 175
               P P   ++ERS D G T+  +QY A   ++C S +    +  P +++   +V C S
Sbjct: 126 AANAPRPGNWILERSLD-GTTFSPWQYYAVSDSECLSRYNITPRRGPPTYRADDEVICTS 184

Query: 176 LPQRPNARLNGGKVQLNLMDLVSGIPATQ--SQKIQEVGEITNLRVNFTR---------- 223
              R    L  G++  +L   ++G P+    S K+ E      +R+   R          
Sbjct: 185 YYSRL-VPLEHGEIHTSL---INGRPSADDLSPKLLEFTSARYIRLRLQRIRTLNADLMT 240

Query: 224 --------LAPVPQRGYHPPSAYYAVSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQV 275
                   L P+  R Y     YY++  + + G C C+GHA  C         P      
Sbjct: 241 LSHREPKELDPIVTRRY-----YYSIKDISVGGMCICYGHASSC---------PWDETTK 286

Query: 276 HDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVF--- 332
              C C+HNT G +C RC P Y+ +PWRP      + C+ C+C+  ++ C++D +V    
Sbjct: 287 KLQCQCEHNTCGESCNRCCPGYHQQPWRPGTVSSGNTCEACNCHNKAKDCYYDESVAKQK 346

Query: 333 ----AASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVP 388
                A Q   GGVC NC  +T G NCE C   Y+R  +      E C  C CDP G++ 
Sbjct: 347 KSLNTAGQFRGGGVCINCLQNTMGINCETCIDGYYRPHKVSPYEDEPCRPCNCDPVGSL- 405

Query: 389 GAPC-----------DPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILG 437
            + C               GQC CKE   GE+CD C+ G     Y +   C  C CN +G
Sbjct: 406 SSVCIKDDLHSDLHNGKQPGQCPCKEGYTGEKCDRCQLG-----YKDYPTCVSCGCNPVG 460

Query: 438 SRRDMPCDEESGRCLCLPNVVGPKCDQCAP--YHWKLASGQGCEPCAC 483
           S  D PC   +G C+C  NV G  CD+C P  Y+ K  + +GC  C C
Sbjct: 461 SASDEPC---TGPCVCKENVEGKACDRCKPGFYNLKEKNPRGCSECFC 505



 Score =  204 bits (518), Expect = 5e-52
 Identities = 137/415 (33%), Positives = 170/415 (40%), Gaps = 101/415 (24%)

Query: 236  SAYYAVSQLRLQG---SCFCHGHADRCAPKPGASAGPSTAVQVHDVCV-CQHNTAGPNCE 291
            S YY V  +   G    C CHGHA  C               VH VC+ C HNT G +CE
Sbjct: 725  SGYYRVDGILFGGICQPCECHGHAAEC--------------NVHGVCIACAHNTTGVHCE 770

Query: 292  RCAPFYNNRPWRPAEGQDAHECQRCDC------NGHSETCHFDPAVFAASQGAYGGVCDN 345
            +C P +   P R   G    +CQ C C      N  S TCH +             VCD 
Sbjct: 771  QCLPGFYGEPSRGTPG----DCQPCACPLTIASNNFSPTCHLNDGDEV--------VCDW 818

Query: 346  CRDHTEGKNCERCQLHYFRNRR-PGASIQETCISCEC----DPDGAVPGAPCDPVTGQCV 400
            C     G  CERC   Y+ N   PG    E+C+ C+C    DP  A     CD VTG+C+
Sbjct: 819  CAPGYSGAWCERCADGYYGNPTVPG----ESCVPCDCSGNVDPSEA---GHCDSVTGECL 871

Query: 401  -CKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVG 459
             C  +  G  C+ C  GF G      + C  C+C++ GS   + C  E+G C C PNV G
Sbjct: 872  KCLGNTDGAHCERCADGFYG-DAVTAKNCRACECHVKGSHSAV-CHLETGLCDCKPNVTG 929

Query: 460  PKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAA---- 515
             +CDQC   ++ L SG GC PC C    S+S  C    GQC C  G  G  C   A    
Sbjct: 930  QQCDQCLHGYYGLDSGHGCRPCNCSVAGSVSDGCTD-EGQCHCVPGVAGKRCDRCAHGFY 988

Query: 516  ------------------------------------IRQCPDRTYG-DVATGCRACDCDF 538
                                                  +C D  +G D   GC+AC+C  
Sbjct: 989  AYQDGSCTPCDCPHTQNTCDPETGECVCPPHTQGVKCEECEDGHWGYDAEVGCQACNCSL 1048

Query: 539  RGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLR 593
             G+    CD  +G C C+    G  CDQC  GY   +P CV C       D DLR
Sbjct: 1049 VGSTHHRCDVVTGHCQCKSKFGGRACDQCSLGY-RDFPDCVPC-------DCDLR 1095



 Score =  101 bits (251), Expect = 5e-21
 Identities = 178/803 (22%), Positives = 301/803 (37%), Gaps = 144/803 (17%)

Query: 399  CVCKEHVQGERCDLCKPGFTG--LTYANPQG-------CHRCDCNILGSRRDMPCDEESG 449
            CVC     G  C  C PG+    L   + +G       C  C CN         CD  +G
Sbjct: 1362 CVCPPGTVGFSCQDCAPGYHRGKLPAGSDRGPRPLVAPCVPCSCN----NHSDTCDPNTG 1417

Query: 450  RCL-CLPNVVGPKCDQCAP-YHWKLA-SGQGCEPCACDPHN---SLSPQC---NQFTGQC 500
            +CL C  N  G  CD C   Y+ K+  S   C  CAC PH+   S SP C        +C
Sbjct: 1418 KCLNCGDNTAGDHCDVCTSGYYGKVTGSASDCALCAC-PHSPPASFSPTCVLEGDHDFRC 1476

Query: 501  P-CREGFGGLMCSAAAIRQCPDRTYGDVAT---GCRACDCDFRGTEGPGCDKASGRCLCR 556
              C  G+ G  C      +C    YG+  T    C+ CDC+  G+    CD+ SG+C+CR
Sbjct: 1477 DACLLGYEGKHCE-----RCSSSYYGNPQTPGGSCQKCDCNPHGSVHGDCDRTSGQCVCR 1531

Query: 557  PGLTGPRCDQCQRGYCNRYPVCVAC-HPCFQTYDADLREQA-------------LRFG-- 600
             G +G RCD+C+  +      CV+C   C      DL E               + +G  
Sbjct: 1532 LGASGLRCDECEPRHILMETDCVSCDDECVGVLLNDLDEIGDAVLSLNLTGIIPVPYGIL 1591

Query: 601  -RLRNATASLWSGPGLED----------RGLASRILDAKSKIEQIRAVLSS-PAVTE--- 645
              L N T  L      E+           G+A    + + K+ ++ A        TE   
Sbjct: 1592 SNLENTTKYLQESLLKENMQKDLGKIKLEGVAEETDNLQKKLTRMLASTQKVNRATERIF 1651

Query: 646  QEVAQVASAI----LSLRRTLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQ-RKR 700
            +E   +A AI    +S+   ++   L+  L+E+ L     L+++ ++   LL + Q R  
Sbjct: 1652 KESQDLAIAIERLQMSITEIMEKTTLNQTLDEDFLLPNSTLQNMQQNGTSLLEIMQIRDF 1711

Query: 701  EQFEKISSADPSGAFRMLSTAYEQSAQAAQQV----SDSSRLLDQLRDSRREAERLVRQA 756
             Q  + ++ +   A  +LS   E   +  +++      +S +L +  +  + AE LVR+A
Sbjct: 1712 TQLHQNATLELKAAEDLLSQIQENYQKPLEELEVLKEAASHVLSKHNNELKAAEALVREA 1771

Query: 757  GGGGGTGSPKLVALRLEMSSLPDLTPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGS 816
                   +  L+ +   +    D      KL     Q   + +   G             
Sbjct: 1772 EAKMQESNHLLLMVNANLREFSD-----KKLHVQEEQNLTSELIVQG------------- 1813

Query: 817  RCRGVLPRAGGAFLMAGQVAEQLRGFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSA 876
              RG++  A           E L     +L      IR   +      S    ++    A
Sbjct: 1814 --RGLIDAAAAQTDAVQDALEHLEDHQDKLLLWSAKIRHHIDDLVMHMSQRNAVDLVYRA 1871

Query: 877  SRSQMEEDVRRTRLLIQQVRDFLTDPDTDAATIQEVS-EAVLALWLPTDSATVLQKMNEI 935
                 E          Q++ D L    +    I+ VS  A  A ++  +  +++++  E+
Sbjct: 1872 EDHAAE---------FQRLADVLY---SGLENIRNVSLNATSAAYVHYNIQSLIEESEEL 1919

Query: 936  QAIAARLPNVDLVLSQT-----KQDIARARRLQAEAEEARSRAHAVEGQVEDVVGNLRQG 990
               A R      +LS++     K  + R+ R   E      +   +  ++ +    LR  
Sbjct: 1920 ARDAHRTVTETSLLSESLVSNGKAAVQRSSRFLKEGNNLSRKLPGIALELSE----LRNK 1975

Query: 991  TVALQE-AQDTMQGTSRSLRLIQDRVAEVQQVLRPAEKLVTSMTKQLGDFWTRMEELRHQ 1049
            T   QE A +  + T+ SL +++                  ++ K + D   + +EL   
Sbjct: 1976 TNRFQENAVEITRQTNESLLILR------------------AIPKGIRDKGAKTKELATS 2017

Query: 1050 ARQQGAEAVQAQQLAEGASEQALSAQEGFERIKQKYAELKDRLGQSSMLG-EQGARIQSV 1108
            A Q    AV   +   G S++ L+      R+     E    L  S+M     G +++ V
Sbjct: 2018 ASQ---SAVSTLRDVAGLSQELLNTSASLSRVNTTLRETHQLLQDSTMATLLAGRKVKDV 2074

Query: 1109 KTEAEELFGETMEMMDRMKDMEL 1131
            + +A  LF       DR+K +++
Sbjct: 2075 EIQANLLF-------DRLKPLKM 2090



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 59/167 (35%), Positives = 76/167 (45%), Gaps = 26/167 (15%)

Query: 250  CFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQD 309
            C C+ H+D C P  G                C  NTAG +C+ C   Y  +    A    
Sbjct: 1403 CSCNNHSDTCDPNTGKCLN------------CGDNTAGDHCDVCTSGYYGKVTGSAS--- 1447

Query: 310  AHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRN-RRP 368
              +C  C C  HS    F P      +G +   CD C    EGK+CERC   Y+ N + P
Sbjct: 1448 --DCALCACP-HSPPASFSPT--CVLEGDHDFRCDACLLGYEGKHCERCSSSYYGNPQTP 1502

Query: 369  GASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKP 415
            G S    C  C+C+P G+V G  CD  +GQCVC+    G RCD C+P
Sbjct: 1503 GGS----CQKCDCNPHGSVHG-DCDRTSGQCVCRLGASGLRCDECEP 1544



 Score = 94.4 bits (233), Expect = 6e-19
 Identities = 69/248 (27%), Positives = 101/248 (40%), Gaps = 51/248 (20%)

Query: 366 RRPGASIQETCISCECDPDGAVPGAPCDPVTG--QCVCKEHVQGERCDLCKPGFTGL--- 420
           RR   SI++  +   C   G     P D  T   QC C+ +  GE C+ C PG+      
Sbjct: 255 RRYYYSIKDISVGGMCICYGHASSCPWDETTKKLQCQCEHNTCGESCNRCCPGYHQQPWR 314

Query: 421 --TYANPQGCHRCDCNILGSRRDMPCDEE----------------SGRCL-CLPNVVGPK 461
             T ++   C  C+C+     +D   DE                  G C+ CL N +G  
Sbjct: 315 PGTVSSGNTCEACNCH--NKAKDCYYDESVAKQKKSLNTAGQFRGGGVCINCLQNTMGIN 372

Query: 462 CDQCA-----PYHWKLASGQGCEPCACDPHNSLSPQC-----------NQFTGQCPCREG 505
           C+ C      P+       + C PC CDP  SLS  C            +  GQCPC+EG
Sbjct: 373 CETCIDGYYRPHKVSPYEDEPCRPCNCDPVGSLSSVCIKDDLHSDLHNGKQPGQCPCKEG 432

Query: 506 FGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCD 565
           + G  C    +       Y D  T C +C C+  G+     +  +G C+C+  + G  CD
Sbjct: 433 YTGEKCDRCQLG------YKDYPT-CVSCGCNPVGSASD--EPCTGPCVCKENVEGKACD 483

Query: 566 QCQRGYCN 573
           +C+ G+ N
Sbjct: 484 RCKPGFYN 491



 Score = 73.9 bits (180), Expect = 8e-13
 Identities = 56/194 (28%), Positives = 73/194 (37%), Gaps = 47/194 (24%)

Query: 250  CFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQD 309
            C C    + C P+ G              CVC  +T G  CE C   +    W    G D
Sbjct: 998  CDCPHTQNTCDPETGE-------------CVCPPHTQGVKCEECEDGH----W----GYD 1036

Query: 310  AHE-CQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRP 368
            A   CQ C+C+    T H    V    Q         C+    G+ C++C L Y      
Sbjct: 1037 AEVGCQACNCSLVGSTHHRCDVVTGHCQ---------CKSKFGGRACDQCSLGY------ 1081

Query: 369  GASIQETCISCECDPDGAVPGA--------PCDPVTGQCVCKEHVQGERCDLCKPGFTGL 420
                   C+ C+CD  G    A         C   TG C CKE+V G +C+ C+ G   L
Sbjct: 1082 --RDFPDCVPCDCDLRGTSGDACNLEQGLCGCVEETGACPCKENVFGPQCNECREGTFAL 1139

Query: 421  TYANPQGCHRCDCN 434
               NP GC  C C+
Sbjct: 1140 RADNPLGCSPCFCS 1153



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 59/193 (30%), Positives = 77/193 (39%), Gaps = 52/193 (26%)

Query: 433 CNILGSRRDMPCDEESGR--CLCLPNVVGPKCDQCAP-YH---WK---LASGQGCEPCAC 483
           C   G     P DE + +  C C  N  G  C++C P YH   W+   ++SG  CE C C
Sbjct: 270 CICYGHASSCPWDETTKKLQCQCEHNTCGESCNRCCPGYHQQPWRPGTVSSGNTCEACNC 329

Query: 484 DPHN---------SLSPQ------CNQFTGQ---CPCREGFGGLMCSAAAIRQCPDRTYG 525
             HN         S++ Q        QF G      C +   G+ C       C D  Y 
Sbjct: 330 --HNKAKDCYYDESVAKQKKSLNTAGQFRGGGVCINCLQNTMGINCET-----CIDGYYR 382

Query: 526 DVATG------CRACDCDFRGTEGPGC-----------DKASGRCLCRPGLTGPRCDQCQ 568
                      CR C+CD  G+    C            K  G+C C+ G TG +CD+CQ
Sbjct: 383 PHKVSPYEDEPCRPCNCDPVGSLSSVCIKDDLHSDLHNGKQPGQCPCKEGYTGEKCDRCQ 442

Query: 569 RGYCNRYPVCVAC 581
            GY   YP CV+C
Sbjct: 443 LGY-KDYPTCVSC 454


>gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo
           sapiens]
          Length = 3118

 Score =  200 bits (509), Expect = 6e-51
 Identities = 145/521 (27%), Positives = 225/521 (43%), Gaps = 88/521 (16%)

Query: 19  QACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYGEW--------QMKCCKCD 70
           QA  +   +P V  L +     +  ++TCG   PE YC              Q + C  +
Sbjct: 32  QAHQQRGLFPAV--LNLASNALITTNATCGEKGPEMYCKLVEHVPGQPVRNPQCRICNQN 89

Query: 71  SRQPHNYYSHRVENVASSSGPMRWWQSQNDVNP-----VSLQLDLDRRFQLQEVMMEF-Q 124
           S  P+    H + N     G   WWQS +  N      V++ LDL + FQ+  V+++   
Sbjct: 90  SSNPNQ--RHPITNAID--GKNTWWQSPSIKNGIEYHYVTITLDLQQVFQIAYVIVKAAN 145

Query: 125 GPMPAGMLIERSSDFG--KTWRVYQYLAADCTSTFPRVRQGRPQSW---QDVRCQSLPQR 179
            P P   ++ERS D    K W+ +     +C + +    +  P S+    +V C S   +
Sbjct: 146 SPRPGNWILERSLDDVEYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSK 205

Query: 180 PNARLNGGKVQLNLMDLVSGIPATQ--SQKIQEVGEITNLRVNFTRLA------------ 225
            +  L  G++ ++L   ++G P+    S ++ E      +R+ F R+             
Sbjct: 206 IHP-LENGEIHISL---INGRPSADDPSPELLEFTSARYIRLRFQRIRTLNADLMMFAHK 261

Query: 226 ------PVPQRGYHPPSAYYAVSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVC 279
                 P+  R Y     YY+V  + + G C C+GHA  C   P  +            C
Sbjct: 262 DPREIDPIVTRRY-----YYSVKDISVGGMCICYGHARACPLDPATNKSR---------C 307

Query: 280 VCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAAS---- 335
            C+HNT G +C++C P ++ +PWR        EC+ C+C+G +E C++D  V   +    
Sbjct: 308 ECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLN 367

Query: 336 -QGAY--GGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAV----- 387
            +G Y  GGVC NC  +T G NCE C   +FR +    +    C  C CDP G++     
Sbjct: 368 IRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCV 427

Query: 388 ---PGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPC 444
                A      G C CK    G  CD C  G+TG        C  C+C+ LGS+ + PC
Sbjct: 428 KDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGY-----PDCKACNCSGLGSKNEDPC 482

Query: 445 DEESGRCLCLPNVVGPKCDQCAPYHWKLA--SGQGCEPCAC 483
               G C+C  NV G  C +C    + L   + +GC+ C C
Sbjct: 483 ---FGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFC 520



 Score =  190 bits (483), Expect = 6e-48
 Identities = 125/389 (32%), Positives = 171/389 (43%), Gaps = 89/389 (22%)

Query: 250  CFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQD 309
            C C GHA+ C    G            +   C+ +T GP C++C P +   P +      
Sbjct: 757  CQCFGHAESCDDVTG------------ECLNCKDHTGGPYCDKCLPGFYGEPTKGT---- 800

Query: 310  AHECQRCDC------NGHSETCHFD----------------PAVFAASQGAYG------- 340
            + +CQ C C      N  S TCH D                P     ++G +G       
Sbjct: 801  SEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGG 860

Query: 341  ----------------GVCDN-------CRDHTEGKNCERCQLHYFRNRRPGASIQETCI 377
                            G CD+       C+  T G+ CE C   YF +    A   + C 
Sbjct: 861  SCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGD----AVDAKNCQ 916

Query: 378  SCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILG 437
             C C+  G+     C   TGQC C+ +VQG+RCD CK G  GL  A  +GC  C+CN  G
Sbjct: 917  PCRCNAGGSF-SEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQSA--RGCVPCNCNSFG 973

Query: 438  SRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFT 497
            S +   C EESG+C C P V G KCD+CA  ++    G GC  C C   + L   C+  T
Sbjct: 974  S-KSFDC-EESGQCWCQPGVTGKKCDRCAHGYFNFQEG-GCTACEC---SHLGNNCDPKT 1027

Query: 498  GQCPCREGFGGLMCSAAAIRQCPDRTYG-DVATGCRACDCDFRGTEGPGCDKASGRCLCR 556
            G+C C     G  CS     +C   T+G  + TGC+AC+C   G+    C+  +G+C C 
Sbjct: 1028 GRCICPPNTIGEKCS-----KCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCH 1082

Query: 557  PGLTGPRCDQCQRGYCNRYPVCVACHPCF 585
            P  +G +C +C RG+ N YP C  C  CF
Sbjct: 1083 PKFSGAKCTECSRGHWN-YPRCNLC-DCF 1109



 Score =  159 bits (403), Expect = 1e-38
 Identities = 104/321 (32%), Positives = 137/321 (42%), Gaps = 44/321 (13%)

Query: 277  DVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQ 336
            +VC C     G +CE C P +         G     C+ C C GH+E+C           
Sbjct: 722  EVCQCPPGYTGSSCESCWPRHRRVNGTIFGGI----CEPCQCFGHAESCD---------- 767

Query: 337  GAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCEC----DPDGAVPGAPC 392
                G C NC+DHT G  C++C   ++     G S  E C  C C      +   P    
Sbjct: 768  -DVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTS--EDCQPCACPLNIPSNNFSPTCHL 824

Query: 393  DPVTGQCV--CKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCN------ILGSRRDMPC 444
            D   G     C     G RC+ C  G+ G        C  C CN      I GS     C
Sbjct: 825  DRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGS-----C 879

Query: 445  DEESGRCL-CLPNVVGPKCDQCAP-YHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPC 502
            D  SG CL C P   G  C+ CA  Y       + C+PC C+   S S  C+  TGQC C
Sbjct: 880  DSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCEC 939

Query: 503  REGFGGLMCSAAAIRQCPDRTYG-DVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTG 561
            R    G  C      +C   T+G   A GC  C+C+  G++   C++ SG+C C+PG+TG
Sbjct: 940  RANVQGQRCD-----KCKAGTFGLQSARGCVPCNCNSFGSKSFDCEE-SGQCWCQPGVTG 993

Query: 562  PRCDQCQRGYCN-RYPVCVAC 581
             +CD+C  GY N +   C AC
Sbjct: 994  KKCDRCAHGYFNFQEGGCTAC 1014



 Score =  113 bits (282), Expect = 1e-24
 Identities = 72/213 (33%), Positives = 92/213 (43%), Gaps = 28/213 (13%)

Query: 279  CVCQHNTAGPNCERCAP-FYNNR--PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAAS 335
            C C    +G +CE C P FY  R  P     G     C  C CNGHS  C  DP      
Sbjct: 1380 CDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLC--DPET---- 1433

Query: 336  QGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCEC----DPDGAVPGAP 391
                  +C NC+ HT G  CERC L Y+   +    +   C  C C      +   P   
Sbjct: 1434 -----SICQNCQHHTAGDFCERCALGYYGIVK---GLPNDCQQCACPLISSSNNFSPSCV 1485

Query: 392  CDPVTG-QC-VCKEHVQGERCDLCKPGFTGLTYANPQG-CHRCDCNILGSRRDMPCDEES 448
             + +   +C  C    +G+ C+ C PG+TG +  NP G C  C+C+  GS   +PCD  +
Sbjct: 1486 AEGLDDYRCTACPRGYEGQYCERCAPGYTG-SPGNPGGSCQECECDPYGS-LPVPCDPVT 1543

Query: 449  GRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPC 481
            G C C P   G KCD C   HW    G  C  C
Sbjct: 1544 GFCTCRPGATGRKCDGCK--HWHAREGWECVFC 1574



 Score =  102 bits (254), Expect = 2e-21
 Identities = 63/166 (37%), Positives = 81/166 (48%), Gaps = 25/166 (15%)

Query: 250  CFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQD 309
            C C+GH+  C P+                  CQH+TAG  CERCA  Y    +   +G  
Sbjct: 1420 CQCNGHSSLCDPETSICQN------------CQHHTAGDFCERCALGY----YGIVKGL- 1462

Query: 310  AHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRN-RRP 368
             ++CQ+C C   S + +F P+  A     Y   C  C    EG+ CERC   Y  +   P
Sbjct: 1463 PNDCQQCACPLISSSNNFSPSCVAEGLDDYR--CTACPRGYEGQYCERCAPGYTGSPGNP 1520

Query: 369  GASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCK 414
            G S QE    CECDP G++P  PCDPVTG C C+    G +CD CK
Sbjct: 1521 GGSCQE----CECDPYGSLP-VPCDPVTGFCTCRPGATGRKCDGCK 1561



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 69/259 (26%), Positives = 102/259 (39%), Gaps = 50/259 (19%)

Query: 366 RRPGASIQETCISCECDPDGAVPGAPCDPVTGQ--CVCKEHVQGERCDLCKPGF-----T 418
           RR   S+++  +   C   G     P DP T +  C C+ +  G+ CD C PGF      
Sbjct: 272 RRYYYSVKDISVGGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWR 331

Query: 419 GLTYANPQGCHRCDCNILGSRRDMPCDEESGR----------------CL-CLPNVVGPK 461
             T+     C  C+C+  G   +   DE   R                C+ C  N  G  
Sbjct: 332 AGTFLTKTECEACNCH--GKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGIN 389

Query: 462 CDQCAPYHWKLAS-----GQGCEPCACDPHNSLSPQCNQ---------FTGQCPCREGFG 507
           C+ C    ++         + C+PC CDP  SL+  C +           G C C+ GFG
Sbjct: 390 CETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFG 449

Query: 508 GLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQC 567
           G+ C   A      R Y      C+AC+C   G++    D   G C+C+  + G  C +C
Sbjct: 450 GVSCDRCA------RGYTGYPD-CKACNCSGLGSKNE--DPCFGPCICKENVEGGDCSRC 500

Query: 568 QRGYCN-RYPVCVACHPCF 585
           + G+ N +      C  CF
Sbjct: 501 KSGFFNLQEDNWKGCDECF 519



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 67/218 (30%), Positives = 90/218 (41%), Gaps = 31/218 (14%)

Query: 385  GAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQG---------CHRCDCNI 435
            G     P D +  +C C     G  C+ C PGF  L  + P G         C  C CN 
Sbjct: 1367 GTTMTPPADLIE-KCDCPLGYSGLSCEACLPGFYRLR-SQPGGRTPGPTLGTCVPCQCNG 1424

Query: 436  LGSRRDMPCDEESGRCL-CLPNVVGPKCDQCAPYHWKLASG--QGCEPCAC---DPHNSL 489
              S     CD E+  C  C  +  G  C++CA  ++ +  G    C+ CAC      N+ 
Sbjct: 1425 HSSL----CDPETSICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNF 1480

Query: 490  SPQC---NQFTGQCP-CREGFGGLMCSAAAIRQCPDRTY--GDVATGCRACDCDFRGTEG 543
            SP C        +C  C  G+ G  C   A    P  T   G+    C+ C+CD  G+  
Sbjct: 1481 SPSCVAEGLDDYRCTACPRGYEGQYCERCA----PGYTGSPGNPGGSCQECECDPYGSLP 1536

Query: 544  PGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVAC 581
              CD  +G C CRPG TG +CD C+  +      CV C
Sbjct: 1537 VPCDPVTGFCTCRPGATGRKCDGCKHWHAREGWECVFC 1574



 Score = 77.8 bits (190), Expect = 6e-14
 Identities = 57/191 (29%), Positives = 67/191 (35%), Gaps = 41/191 (21%)

Query: 249  SCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQ 308
            +C C    + C PK G              C+C  NT G  C +CAP  N        G 
Sbjct: 1013 ACECSHLGNNCDPKTGR-------------CICPPNTIGEKCSKCAP--NTWGHSITTGC 1057

Query: 309  DAHECQRC-----DCNGHSETCHFDPAVFAASQGAYGGVCDNC-RDHTEGKNCERCQLHY 362
             A  C         CN ++  C+  P          G  C  C R H     C  C    
Sbjct: 1058 KACNCSTVGSLDFQCNVNTGQCNCHPKF-------SGAKCTECSRGHWNYPRCNLCDCFL 1110

Query: 363  FRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTY 422
                 PG     TC       D       C   TGQC CK +V+G  CD C+PG  GL  
Sbjct: 1111 -----PGTD-ATTC-------DSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDA 1157

Query: 423  ANPQGCHRCDC 433
             NP GC  C C
Sbjct: 1158 KNPLGCSSCYC 1168


>gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo
           sapiens]
          Length = 3122

 Score =  200 bits (509), Expect = 6e-51
 Identities = 145/521 (27%), Positives = 225/521 (43%), Gaps = 88/521 (16%)

Query: 19  QACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYGEW--------QMKCCKCD 70
           QA  +   +P V  L +     +  ++TCG   PE YC              Q + C  +
Sbjct: 32  QAHQQRGLFPAV--LNLASNALITTNATCGEKGPEMYCKLVEHVPGQPVRNPQCRICNQN 89

Query: 71  SRQPHNYYSHRVENVASSSGPMRWWQSQNDVNP-----VSLQLDLDRRFQLQEVMMEF-Q 124
           S  P+    H + N     G   WWQS +  N      V++ LDL + FQ+  V+++   
Sbjct: 90  SSNPNQ--RHPITNAID--GKNTWWQSPSIKNGIEYHYVTITLDLQQVFQIAYVIVKAAN 145

Query: 125 GPMPAGMLIERSSDFG--KTWRVYQYLAADCTSTFPRVRQGRPQSW---QDVRCQSLPQR 179
            P P   ++ERS D    K W+ +     +C + +    +  P S+    +V C S   +
Sbjct: 146 SPRPGNWILERSLDDVEYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSK 205

Query: 180 PNARLNGGKVQLNLMDLVSGIPATQ--SQKIQEVGEITNLRVNFTRLA------------ 225
            +  L  G++ ++L   ++G P+    S ++ E      +R+ F R+             
Sbjct: 206 IHP-LENGEIHISL---INGRPSADDPSPELLEFTSARYIRLRFQRIRTLNADLMMFAHK 261

Query: 226 ------PVPQRGYHPPSAYYAVSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVC 279
                 P+  R Y     YY+V  + + G C C+GHA  C   P  +            C
Sbjct: 262 DPREIDPIVTRRY-----YYSVKDISVGGMCICYGHARACPLDPATNKSR---------C 307

Query: 280 VCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAAS---- 335
            C+HNT G +C++C P ++ +PWR        EC+ C+C+G +E C++D  V   +    
Sbjct: 308 ECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLN 367

Query: 336 -QGAY--GGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAV----- 387
            +G Y  GGVC NC  +T G NCE C   +FR +    +    C  C CDP G++     
Sbjct: 368 IRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCV 427

Query: 388 ---PGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPC 444
                A      G C CK    G  CD C  G+TG        C  C+C+ LGS+ + PC
Sbjct: 428 KDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGY-----PDCKACNCSGLGSKNEDPC 482

Query: 445 DEESGRCLCLPNVVGPKCDQCAPYHWKLA--SGQGCEPCAC 483
               G C+C  NV G  C +C    + L   + +GC+ C C
Sbjct: 483 ---FGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFC 520



 Score =  190 bits (483), Expect = 6e-48
 Identities = 125/389 (32%), Positives = 171/389 (43%), Gaps = 89/389 (22%)

Query: 250  CFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQD 309
            C C GHA+ C    G            +   C+ +T GP C++C P +   P +      
Sbjct: 757  CQCFGHAESCDDVTG------------ECLNCKDHTGGPYCDKCLPGFYGEPTKGT---- 800

Query: 310  AHECQRCDC------NGHSETCHFD----------------PAVFAASQGAYG------- 340
            + +CQ C C      N  S TCH D                P     ++G +G       
Sbjct: 801  SEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGG 860

Query: 341  ----------------GVCDN-------CRDHTEGKNCERCQLHYFRNRRPGASIQETCI 377
                            G CD+       C+  T G+ CE C   YF +    A   + C 
Sbjct: 861  SCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGD----AVDAKNCQ 916

Query: 378  SCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILG 437
             C C+  G+     C   TGQC C+ +VQG+RCD CK G  GL  A  +GC  C+CN  G
Sbjct: 917  PCRCNAGGSF-SEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQSA--RGCVPCNCNSFG 973

Query: 438  SRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFT 497
            S +   C EESG+C C P V G KCD+CA  ++    G GC  C C   + L   C+  T
Sbjct: 974  S-KSFDC-EESGQCWCQPGVTGKKCDRCAHGYFNFQEG-GCTACEC---SHLGNNCDPKT 1027

Query: 498  GQCPCREGFGGLMCSAAAIRQCPDRTYG-DVATGCRACDCDFRGTEGPGCDKASGRCLCR 556
            G+C C     G  CS     +C   T+G  + TGC+AC+C   G+    C+  +G+C C 
Sbjct: 1028 GRCICPPNTIGEKCS-----KCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCH 1082

Query: 557  PGLTGPRCDQCQRGYCNRYPVCVACHPCF 585
            P  +G +C +C RG+ N YP C  C  CF
Sbjct: 1083 PKFSGAKCTECSRGHWN-YPRCNLC-DCF 1109



 Score =  159 bits (403), Expect = 1e-38
 Identities = 104/321 (32%), Positives = 137/321 (42%), Gaps = 44/321 (13%)

Query: 277  DVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQ 336
            +VC C     G +CE C P +         G     C+ C C GH+E+C           
Sbjct: 722  EVCQCPPGYTGSSCESCWPRHRRVNGTIFGGI----CEPCQCFGHAESCD---------- 767

Query: 337  GAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCEC----DPDGAVPGAPC 392
                G C NC+DHT G  C++C   ++     G S  E C  C C      +   P    
Sbjct: 768  -DVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTS--EDCQPCACPLNIPSNNFSPTCHL 824

Query: 393  DPVTGQCV--CKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCN------ILGSRRDMPC 444
            D   G     C     G RC+ C  G+ G        C  C CN      I GS     C
Sbjct: 825  DRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGS-----C 879

Query: 445  DEESGRCL-CLPNVVGPKCDQCAP-YHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPC 502
            D  SG CL C P   G  C+ CA  Y       + C+PC C+   S S  C+  TGQC C
Sbjct: 880  DSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCEC 939

Query: 503  REGFGGLMCSAAAIRQCPDRTYG-DVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTG 561
            R    G  C      +C   T+G   A GC  C+C+  G++   C++ SG+C C+PG+TG
Sbjct: 940  RANVQGQRCD-----KCKAGTFGLQSARGCVPCNCNSFGSKSFDCEE-SGQCWCQPGVTG 993

Query: 562  PRCDQCQRGYCN-RYPVCVAC 581
             +CD+C  GY N +   C AC
Sbjct: 994  KKCDRCAHGYFNFQEGGCTAC 1014



 Score =  113 bits (282), Expect = 1e-24
 Identities = 72/213 (33%), Positives = 92/213 (43%), Gaps = 28/213 (13%)

Query: 279  CVCQHNTAGPNCERCAP-FYNNR--PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAAS 335
            C C    +G +CE C P FY  R  P     G     C  C CNGHS  C  DP      
Sbjct: 1380 CDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLC--DPET---- 1433

Query: 336  QGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCEC----DPDGAVPGAP 391
                  +C NC+ HT G  CERC L Y+   +    +   C  C C      +   P   
Sbjct: 1434 -----SICQNCQHHTAGDFCERCALGYYGIVK---GLPNDCQQCACPLISSSNNFSPSCV 1485

Query: 392  CDPVTG-QC-VCKEHVQGERCDLCKPGFTGLTYANPQG-CHRCDCNILGSRRDMPCDEES 448
             + +   +C  C    +G+ C+ C PG+TG +  NP G C  C+C+  GS   +PCD  +
Sbjct: 1486 AEGLDDYRCTACPRGYEGQYCERCAPGYTG-SPGNPGGSCQECECDPYGS-LPVPCDPVT 1543

Query: 449  GRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPC 481
            G C C P   G KCD C   HW    G  C  C
Sbjct: 1544 GFCTCRPGATGRKCDGCK--HWHAREGWECVFC 1574



 Score =  102 bits (254), Expect = 2e-21
 Identities = 63/166 (37%), Positives = 81/166 (48%), Gaps = 25/166 (15%)

Query: 250  CFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQD 309
            C C+GH+  C P+                  CQH+TAG  CERCA  Y    +   +G  
Sbjct: 1420 CQCNGHSSLCDPETSICQN------------CQHHTAGDFCERCALGY----YGIVKGL- 1462

Query: 310  AHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRN-RRP 368
             ++CQ+C C   S + +F P+  A     Y   C  C    EG+ CERC   Y  +   P
Sbjct: 1463 PNDCQQCACPLISSSNNFSPSCVAEGLDDYR--CTACPRGYEGQYCERCAPGYTGSPGNP 1520

Query: 369  GASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCK 414
            G S QE    CECDP G++P  PCDPVTG C C+    G +CD CK
Sbjct: 1521 GGSCQE----CECDPYGSLP-VPCDPVTGFCTCRPGATGRKCDGCK 1561



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 69/259 (26%), Positives = 102/259 (39%), Gaps = 50/259 (19%)

Query: 366 RRPGASIQETCISCECDPDGAVPGAPCDPVTGQ--CVCKEHVQGERCDLCKPGF-----T 418
           RR   S+++  +   C   G     P DP T +  C C+ +  G+ CD C PGF      
Sbjct: 272 RRYYYSVKDISVGGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWR 331

Query: 419 GLTYANPQGCHRCDCNILGSRRDMPCDEESGR----------------CL-CLPNVVGPK 461
             T+     C  C+C+  G   +   DE   R                C+ C  N  G  
Sbjct: 332 AGTFLTKTECEACNCH--GKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGIN 389

Query: 462 CDQCAPYHWKLAS-----GQGCEPCACDPHNSLSPQCNQ---------FTGQCPCREGFG 507
           C+ C    ++         + C+PC CDP  SL+  C +           G C C+ GFG
Sbjct: 390 CETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFG 449

Query: 508 GLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQC 567
           G+ C   A      R Y      C+AC+C   G++    D   G C+C+  + G  C +C
Sbjct: 450 GVSCDRCA------RGYTGYPD-CKACNCSGLGSKNE--DPCFGPCICKENVEGGDCSRC 500

Query: 568 QRGYCN-RYPVCVACHPCF 585
           + G+ N +      C  CF
Sbjct: 501 KSGFFNLQEDNWKGCDECF 519



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 67/218 (30%), Positives = 90/218 (41%), Gaps = 31/218 (14%)

Query: 385  GAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQG---------CHRCDCNI 435
            G     P D +  +C C     G  C+ C PGF  L  + P G         C  C CN 
Sbjct: 1367 GTTMTPPADLIE-KCDCPLGYSGLSCEACLPGFYRLR-SQPGGRTPGPTLGTCVPCQCNG 1424

Query: 436  LGSRRDMPCDEESGRCL-CLPNVVGPKCDQCAPYHWKLASG--QGCEPCAC---DPHNSL 489
              S     CD E+  C  C  +  G  C++CA  ++ +  G    C+ CAC      N+ 
Sbjct: 1425 HSSL----CDPETSICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNF 1480

Query: 490  SPQC---NQFTGQCP-CREGFGGLMCSAAAIRQCPDRTY--GDVATGCRACDCDFRGTEG 543
            SP C        +C  C  G+ G  C   A    P  T   G+    C+ C+CD  G+  
Sbjct: 1481 SPSCVAEGLDDYRCTACPRGYEGQYCERCA----PGYTGSPGNPGGSCQECECDPYGSLP 1536

Query: 544  PGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVAC 581
              CD  +G C CRPG TG +CD C+  +      CV C
Sbjct: 1537 VPCDPVTGFCTCRPGATGRKCDGCKHWHAREGWECVFC 1574



 Score = 77.8 bits (190), Expect = 6e-14
 Identities = 57/191 (29%), Positives = 67/191 (35%), Gaps = 41/191 (21%)

Query: 249  SCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQ 308
            +C C    + C PK G              C+C  NT G  C +CAP  N        G 
Sbjct: 1013 ACECSHLGNNCDPKTGR-------------CICPPNTIGEKCSKCAP--NTWGHSITTGC 1057

Query: 309  DAHECQRC-----DCNGHSETCHFDPAVFAASQGAYGGVCDNC-RDHTEGKNCERCQLHY 362
             A  C         CN ++  C+  P          G  C  C R H     C  C    
Sbjct: 1058 KACNCSTVGSLDFQCNVNTGQCNCHPKF-------SGAKCTECSRGHWNYPRCNLCDCFL 1110

Query: 363  FRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTY 422
                 PG     TC       D       C   TGQC CK +V+G  CD C+PG  GL  
Sbjct: 1111 -----PGTD-ATTC-------DSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDA 1157

Query: 423  ANPQGCHRCDC 433
             NP GC  C C
Sbjct: 1158 KNPLGCSSCYC 1168


>gi|5453810 netrin 3 [Homo sapiens]
          Length = 580

 Score =  196 bits (498), Expect = 1e-49
 Identities = 127/414 (30%), Positives = 196/414 (47%), Gaps = 45/414 (10%)

Query: 16  HAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYGEWQMKCCKCDSRQPH 75
           H +    RG C P + +  +GR   + ASSTCG  +P T              CD+  P 
Sbjct: 31  HDEGGAPRG-CVPGLVNAALGRE--VLASSTCG--RPATRA------------CDASDPR 73

Query: 76  NYYSHRV-ENVASSSGPMRWWQSQNDVNP--VSLQLDLDRRFQLQEVMMEFQGPMPAGML 132
             +S  +  +   ++ P+ W        P  V+L + L + F+L  V + F    PA + 
Sbjct: 74  RAHSPALLTSPGGTASPLCWRSESLPRAPLNVTLTVPLGKAFELVFVSLRFCSAPPASVA 133

Query: 133 IERSSDFGKTWRVYQYLAADCTSTFPRV---RQGRPQSWQDVRCQSLP-QRPNARLNGGK 188
           + +S D G++W    + ++ C   + R+     G      +  C   P  +P+     G 
Sbjct: 134 LLKSQDHGRSWAPLGFFSSHCDLDYGRLPAPANGPAGPGPEALCFPAPLAQPDG---SGL 190

Query: 189 VQLNLMDLVS-GIPATQSQKIQEVGEITNLRVNFTRLA----PVPQRGYHPPSAYYAVSQ 243
           +  ++ D    G+    S  +Q+    T++RV  TR +    P       P S  YA + 
Sbjct: 191 LAFSMQDSSPPGLDLDSSPVLQDWVTATDVRVVLTRPSTAGDPRDMEAVVPYS--YAATD 248

Query: 244 LRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWR 303
           L++ G C C+GHA RC              Q H +C C+H T GP+C RC PFY +RPW+
Sbjct: 249 LQVGGRCKCNGHASRCL----------LDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQ 298

Query: 304 PAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYF 363
            A  +++H C  C CNGH+  C F+  ++  S    GGVC NCR +T G++C  C+  ++
Sbjct: 299 RATARESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFY 358

Query: 364 RNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGF 417
           R+     S +  C +C+C P GA  G  C+  TGQC CK+ V G  C+ C PGF
Sbjct: 359 RDPGRALSDRRACRACDCHPVGAA-GKTCNQTTGQCPCKDGVTGLTCNRCAPGF 411



 Score = 70.5 bits (171), Expect = 9e-12
 Identities = 51/183 (27%), Positives = 80/183 (43%), Gaps = 37/183 (20%)

Query: 430 RCDCN------ILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYH----WKLASGQ--- 476
           RC CN      +L ++  + CD       C     GP C +C P++    W+ A+ +   
Sbjct: 254 RCKCNGHASRCLLDTQGHLICD-------CRHGTEGPDCGRCKPFYCDRPWQRATARESH 306

Query: 477 GCEPCACDPHNS---LSPQCNQFTGQ------CPCREGFGGLMCSAA--AIRQCPDRTYG 525
            C  C+C+ H      + +  + +G+        CR    G  C        + P R   
Sbjct: 307 ACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALS 366

Query: 526 DVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGY-CNRYPVCVACHPC 584
           D    CRACDC   G  G  C++ +G+C C+ G+TG  C++C  G+  +R PV     PC
Sbjct: 367 D-RRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQSRSPVA----PC 421

Query: 585 FQT 587
            +T
Sbjct: 422 VKT 424



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 43/135 (31%), Positives = 55/135 (40%), Gaps = 18/135 (13%)

Query: 399 CVCKEHVQGERCDLCKPGFTG-----LTYANPQGCHRCDCN--ILGSRRDMPCDEESGR- 450
           C C+   +G  C  CKP +        T      C  C CN      R +M     SGR 
Sbjct: 274 CDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGRR 333

Query: 451 ----CL-CLPNVVGPKCDQCAPYHWK-----LASGQGCEPCACDPHNSLSPQCNQFTGQC 500
               CL C  N  G  C  C    ++     L+  + C  C C P  +    CNQ TGQC
Sbjct: 334 SGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQC 393

Query: 501 PCREGFGGLMCSAAA 515
           PC++G  GL C+  A
Sbjct: 394 PCKDGVTGLTCNRCA 408


>gi|164414431 netrin G1 isoform 1 [Homo sapiens]
          Length = 539

 Score =  162 bits (409), Expect = 2e-39
 Identities = 131/489 (26%), Positives = 212/489 (43%), Gaps = 87/489 (17%)

Query: 25  ACYPPVGDLLVGRTRFLRASS-----TCGLTKPETYCTQYGEWQMKCCKCDSRQPHNYYS 79
           AC P   D+    T++L+        TCG   PET+C   G   M   +CD+  P    +
Sbjct: 49  ACQPESTDM----TKYLKVKLDPPDITCG-DPPETFCAM-GNPYMCNNECDASTPE--LA 100

Query: 80  HRVENVASSSG--PMRWWQSQNDVN-----PVSLQLDLDRRFQLQE-VMMEFQGPMPAGM 131
           H  E +    G  P  +WQS           V++ L   +  +L + +++ F+   P  M
Sbjct: 101 HPPELMFDFEGRHPSTFWQSATWKEYPKPLQVNITLSWSKTIELTDNIVITFESGRPDQM 160

Query: 132 LIERSSDFGKTWRVYQYLAADCTSTF----PRVRQGRPQSWQDVRCQ---SLPQRPNARL 184
           ++E+S D+G+TW+ YQY A DC   F      V+     +  ++ C    S     N+++
Sbjct: 161 ILEKSLDYGRTWQPYQYYATDCLDAFHMDPKSVKDLSQHTVLEIICTEEYSTGYTTNSKI 220

Query: 185 NGGKVQ-----------LNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLA--PVPQRG 231
              +++            N+  L   +  T+  K+++   +T+LR+   R A   +    
Sbjct: 221 IHFEIKDRFAFFAGPRLRNMASLYGQLDTTK--KLRDFFTVTDLRIRLLRPAVGEIFVDE 278

Query: 232 YHPPSAYYAVSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHD----VCVCQHNTAG 287
            H    +YA+S ++++G C C+ HA  C               V+D     C C+HNT G
Sbjct: 279 LHLARYFYAISDIKVRGRCKCNLHATVC---------------VYDNSKLTCECEHNTTG 323

Query: 288 PNCERCAPFYNNRPWRPAE-----GQDAHEC-------QRCDCNGHSETCHFDPAVFAAS 335
           P+C +C   Y  RPW P          A+ C         C+C GHS  C +   +    
Sbjct: 324 PDCGKCKKNYQGRPWSPGSYLPIPKGTANTCIPSISSIGNCECFGHSNRCSYIDLLNTV- 382

Query: 336 QGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCDPV 395
                 +C +C+ +T G++CE C+L YFRN       +  CI C C+P G++    C+  
Sbjct: 383 ------ICVSCKHNTRGQHCELCRLGYFRNASAQLDDENVCIECYCNPLGSIHDR-CNG- 434

Query: 396 TGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLP 455
           +G C CK    G +CD C PG +      P   + CD  +L  +    C   + RCLC  
Sbjct: 435 SGFCECKTGTTGPKCDECLPGNSWHYGCQP---NVCDNELLHCQNGGTC-HNNVRCLCPA 490

Query: 456 NVVGPKCDQ 464
              G  C++
Sbjct: 491 AYTGILCEK 499



 Score = 57.4 bits (137), Expect = 8e-08
 Identities = 48/193 (24%), Positives = 73/193 (37%), Gaps = 33/193 (17%)

Query: 399 CVCKEHVQGERCDLCKPGFTGLTYAN------PQGCHRCDCNILGSRRDMPCDEESGRCL 452
           C C+ +  G  C  CK  + G  ++       P+G        + S  +  C   S RC 
Sbjct: 315 CECEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPKGTANTCIPSISSIGNCECFGHSNRCS 374

Query: 453 ------------CLPNVVGPKCDQCAPYHWKLASGQ-----GCEPCACDPHNSLSPQCNQ 495
                       C  N  G  C+ C   +++ AS Q      C  C C+P  S+  +CN 
Sbjct: 375 YIDLLNTVICVSCKHNTRGQHCELCRLGYFRNASAQLDDENVCIECYCNPLGSIHDRCNG 434

Query: 496 FTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCR--ACDCDFRGTEGPGCDKASGRC 553
            +G C C+ G  G  C        P  ++     GC+   CD +    +  G    + RC
Sbjct: 435 -SGFCECKTGTTGPKCDECL----PGNSWH---YGCQPNVCDNELLHCQNGGTCHNNVRC 486

Query: 554 LCRPGLTGPRCDQ 566
           LC    TG  C++
Sbjct: 487 LCPAAYTGILCEK 499



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 46/178 (25%), Positives = 62/178 (34%), Gaps = 33/178 (18%)

Query: 430 RCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAP-YHWKLASGQGCEPCACDPHNS 488
           RC CN+  +      D     C C  N  GP C +C   Y  +  S     P      N+
Sbjct: 296 RCKCNLHATV--CVYDNSKLTCECEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPKGTANT 353

Query: 489 LSPQCNQFTGQCPC-----REGFGGLMCSAAAIRQCPDRTYGDVATGCRA---------- 533
             P  +   G C C     R  +  L+ +   +  C   T G     CR           
Sbjct: 354 CIPSISSI-GNCECFGHSNRCSYIDLLNTVICV-SCKHNTRGQHCELCRLGYFRNASAQL 411

Query: 534 --------CDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHP 583
                   C C+  G+    C+  SG C C+ G TGP+CD+C  G    Y     C P
Sbjct: 412 DDENVCIECYCNPLGSIHDRCN-GSGFCECKTGTTGPKCDECLPGNSWHY----GCQP 464


>gi|24308065 netrin 5 [Homo sapiens]
          Length = 489

 Score =  156 bits (395), Expect = 1e-37
 Identities = 78/196 (39%), Positives = 100/196 (51%), Gaps = 25/196 (12%)

Query: 235 PSAYYAVSQLR-------------LQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVC 281
           P A  A S LR             L+G C CHGHA RCA    A A P         C C
Sbjct: 129 PKATVAASHLRVEFGGQAGLAAAGLRGRCQCHGHAARCA----ARARPPR-------CHC 177

Query: 282 QHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGG 341
           +H+T GP CE C P + + PWRPA  +  H C  C CN H+  C F+  +F  S G  GG
Sbjct: 178 RHHTTGPGCESCRPSHRDWPWRPATPRHPHPCLPCSCNQHARRCRFNSELFRLSGGRSGG 237

Query: 342 VCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVC 401
           VC+ CR HT G++C  CQ  ++R+       +  C +C+C P GA  G  C+  +GQC C
Sbjct: 238 VCERCRHHTAGRHCHYCQPGFWRDPSQPIFSRRACRACQCHPIGAT-GGTCNQTSGQCTC 296

Query: 402 KEHVQGERCDLCKPGF 417
           K  V G  C+ C PG+
Sbjct: 297 KLGVTGLTCNRCGPGY 312



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 53/181 (29%), Positives = 74/181 (40%), Gaps = 37/181 (20%)

Query: 416 GFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYH----WK 471
           G  GL  A  +G  RC C+  G            RC C  +  GP C+ C P H    W+
Sbjct: 144 GQAGLAAAGLRG--RCQCH--GHAARCAARARPPRCHCRHHTTGPGCESCRPSHRDWPWR 199

Query: 472 LASGQG---CEPCACDPHNSLSPQCN-----------QFTGQCP-CREGFGGLMCSAAAI 516
            A+ +    C PC+C+ H   + +C            +  G C  CR    G  C     
Sbjct: 200 PATPRHPHPCLPCSCNQH---ARRCRFNSELFRLSGGRSGGVCERCRHHTAGRHC----- 251

Query: 517 RQCPDRTYGDVAT------GCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRG 570
             C    + D +        CRAC C   G  G  C++ SG+C C+ G+TG  C++C  G
Sbjct: 252 HYCQPGFWRDPSQPIFSRRACRACQCHPIGATGGTCNQTSGQCTCKLGVTGLTCNRCGPG 311

Query: 571 Y 571
           Y
Sbjct: 312 Y 312


>gi|190014607 netrin G2 [Homo sapiens]
          Length = 530

 Score =  152 bits (383), Expect = 2e-36
 Identities = 122/464 (26%), Positives = 196/464 (42%), Gaps = 72/464 (15%)

Query: 46  TCGLTKPETYCTQYGEWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQS---QNDVN 102
           TCG   PE +C+    + +   +CD+  P   +  R+       G   +WQS       +
Sbjct: 60  TCG-DPPERFCSHENPY-LCSNECDASNPDLAHPPRLMFDKEEEGLATYWQSITWSRYPS 117

Query: 103 PVSLQLDLDRRFQLQ---EVMMEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFP- 158
           P+   + L     ++   +V+M F+   P  M++E+S D G+TW+ YQ+ A DC   F  
Sbjct: 118 PLEANITLSWNKTVELTDDVVMTFEYGRPTVMVLEKSLDNGRTWQPYQFYAEDCMEAFGM 177

Query: 159 ---RVRQGRPQSWQDVRCQS---------------LPQRPNARLNGGKVQLNLMDLVSGI 200
              R R     S   V C                    R    +  G    N+ +L + +
Sbjct: 178 SARRARDMSSSSAHRVLCTEEYSRWAGSKKEKHVRFEVRDRFAIFAGPDLRNMDNLYTRL 237

Query: 201 PATQSQKIQEVGEITNLRVNFTR--LAPVPQRGYHPPSAYYAVSQLRLQGSCFCHGHADR 258
            + +  K  E   +T+LR+   R  L     +  +    +YA+S + + G C C+ HA+ 
Sbjct: 238 ESAKGLK--EFFTLTDLRMRLLRPALGGTYVQRENLYKYFYAISNIEVIGRCKCNLHANL 295

Query: 259 CAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWR-----------PAEG 307
           C+ + G+             C C+HNT GP+C +C   +  R WR           P   
Sbjct: 296 CSMREGSLQ-----------CECEHNTTGPDCGKCKKNFRTRSWRAGSYLPLPHGSPNAC 344

Query: 308 QDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRR 367
             A     C+C GHS  C +   +   +       C +C+ +T G++C+ C+L Y+RN  
Sbjct: 345 ATAGSFGNCECYGHSNRCSYIDFLNVVT-------CVSCKHNTRGQHCQHCRLGYYRNGS 397

Query: 368 PGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQG 427
                +  CI C C+  G+V    C+  TG C C+E   G +CD C P     T+   QG
Sbjct: 398 AELDDENVCIECNCNQIGSVHDR-CNE-TGFCECREGAAGPKCDDCLP-----THYWRQG 450

Query: 428 CHR--CDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQ--CAP 467
           C+   CD + L  +    C  ++ RC C     G +C+Q  C P
Sbjct: 451 CYPNVCDDDQLLCQNGGTC-LQNQRCACPRGYTGVRCEQPRCDP 493



 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 62/218 (28%), Positives = 91/218 (41%), Gaps = 38/218 (17%)

Query: 315 RCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHY-FRNRRPGASIQ 373
           RC CN H+  C              G +   C  +T G +C +C+ ++  R+ R G+ + 
Sbjct: 286 RCKCNLHANLCSMRE----------GSLQCECEHNTTGPDCGKCKKNFRTRSWRAGSYLP 335

Query: 374 ETCISCE-CDPDGAVPGAPCDPVTGQCV------------CKEHVQGERCDLCKPGF--T 418
               S   C   G+     C   + +C             CK + +G+ C  C+ G+   
Sbjct: 336 LPHGSPNACATAGSFGNCECYGHSNRCSYIDFLNVVTCVSCKHNTRGQHCQHCRLGYYRN 395

Query: 419 GLTYANPQG-CHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYH-WKLASGQ 476
           G    + +  C  C+CN +GS  D  C+E +G C C     GPKCD C P H W+    Q
Sbjct: 396 GSAELDDENVCIECNCNQIGSVHDR-CNE-TGFCECREGAAGPKCDDCLPTHYWR----Q 449

Query: 477 GCEPCACDPHNSLSPQ---CNQFTGQCPCREGFGGLMC 511
           GC P  CD    L      C Q   +C C  G+ G+ C
Sbjct: 450 GCYPNVCDDDQLLCQNGGTCLQ-NQRCACPRGYTGVRC 486



 Score = 67.4 bits (163), Expect = 8e-11
 Identities = 54/192 (28%), Positives = 68/192 (35%), Gaps = 30/192 (15%)

Query: 398 QCVCKEHVQGERCDLCKPGF------TGLTYANPQGCHRCDCNILGSRRDMPCDEESGRC 451
           QC C+ +  G  C  CK  F       G     P G     C   GS  +  C   S RC
Sbjct: 304 QCECEHNTTGPDCGKCKKNFRTRSWRAGSYLPLPHGSPNA-CATAGSFGNCECYGHSNRC 362

Query: 452 L------------CLPNVVGPKCDQCAPYHWKLASGQ-----GCEPCACDPHNSLSPQCN 494
                        C  N  G  C  C   +++  S +      C  C C+   S+  +CN
Sbjct: 363 SYIDFLNVVTCVSCKHNTRGQHCQHCRLGYYRNGSAELDDENVCIECNCNQIGSVHDRCN 422

Query: 495 QFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCL 554
           + TG C CREG  G  C       C    Y         CD D    +  G    + RC 
Sbjct: 423 E-TGFCECREGAAGPKCD-----DCLPTHYWRQGCYPNVCDDDQLLCQNGGTCLQNQRCA 476

Query: 555 CRPGLTGPRCDQ 566
           C  G TG RC+Q
Sbjct: 477 CPRGYTGVRCEQ 488



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 42/164 (25%), Positives = 60/164 (36%), Gaps = 34/164 (20%)

Query: 430 RCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYH----WKLASGQGC---EPCA 482
           RC CN+  +   M   E S +C C  N  GP C +C        W+  S        P A
Sbjct: 286 RCKCNLHANLCSMR--EGSLQCECEHNTTGPDCGKCKKNFRTRSWRAGSYLPLPHGSPNA 343

Query: 483 CDPHNSLSP-QCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRA-------- 533
           C    S    +C   + +C   +    + C +     C   T G     CR         
Sbjct: 344 CATAGSFGNCECYGHSNRCSYIDFLNVVTCVS-----CKHNTRGQHCQHCRLGYYRNGSA 398

Query: 534 ----------CDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQC 567
                     C+C+  G+    C++ +G C CR G  GP+CD C
Sbjct: 399 ELDDENVCIECNCNQIGSVHDRCNE-TGFCECREGAAGPKCDDC 441


>gi|157419138 laminin, gamma 2 isoform a precursor [Homo sapiens]
          Length = 1193

 Score =  138 bits (347), Expect = 4e-32
 Identities = 169/785 (21%), Positives = 306/785 (38%), Gaps = 82/785 (10%)

Query: 351  EGKNCERCQLHYFRNRRPGASIQE--TCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGE 408
            +G+ C+ C   Y   +R  A +    TCI C C   GA     CDP TG C   +     
Sbjct: 389  KGQFCQDCASGY---KRDSARLGPFGTCIPCNCQGGGA-----CDPDTGDCYSGDENPDI 440

Query: 409  RCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPY 468
             C  C  GF    + +P+ C  C C+   S   MP  EE     C P V G +C+ CA  
Sbjct: 441  ECADCPIGFYNDPH-DPRSCKPCPCHNGFSCSVMPETEEVVCNNCPPGVTGARCELCADG 499

Query: 469  HWKLASGQ-----GCEPCACDPH--NSLSPQCNQFTGQC-PCREGFGGLMCSAAAIRQCP 520
            ++    G+      C+PC C+ +   S S  C++ TG+C  C     G+ C         
Sbjct: 500  YFGDPFGEHGPVRPCQPCQCNNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQCKAGYFG 559

Query: 521  DRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVA 580
            D    + A  CRAC+C+  G+E  GC ++ G C+C+PG  GP C+              +
Sbjct: 560  DPLAPNPADKCRACNCNPMGSEPVGC-RSDGTCVCKPGFGGPNCEH----------GAFS 608

Query: 581  CHPCFQTYDADLREQALRFGRLRNATASLWSGPG-LEDRGLASRILDAKSKIEQI--RAV 637
            C  C+      + +   +  R+    +    G G + D  L  R+  A+  ++ I   A 
Sbjct: 609  CPACYNQVKIQMDQFMQQLQRMEALISKAQGGDGVVPDTELEGRMQQAEQALQDILRDAQ 668

Query: 638  LSSPAVTE--QEVAQVASAILSLRRTLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTM 695
            +S  A      ++A+V S   S +  L  L++ +   E   +L    ++  R  + L+T 
Sbjct: 669  ISEGASRSLGLQLAKVRSQENSYQSRLDDLKMTV---ERVRALGSQYQNRVRDTHRLITQ 725

Query: 696  YQRKREQFE------KISSAD----PSGAFRMLSTAYEQSAQAAQQVSDSSRLLDQLRDS 745
             Q    + E       I ++D    P+G   +   A   +    +  S+  +L  +  D 
Sbjct: 726  MQLSLAESEASLGNTNIPASDHYVGPNGFKSLAQEATRLAESHVESASNMEQLTRETEDY 785

Query: 746  RREAERLVRQA---GGGGGTGSPKLVALRLEMSSLPDLTPTFNKLCGNSRQMACTPISCP 802
             ++A  LVR+A   G G G+GSP    ++  +  L        +L   + Q         
Sbjct: 786  SKQALSLVRKALHEGVGSGSGSPDGAVVQGLVEKLEKTKSLAQQLTREATQAE------- 838

Query: 803  GELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR------GFNAQLQRTRQMIRAA 856
                  D       R    + R  G    + QV E  R        ++ + R     +  
Sbjct: 839  ---IEADRSYQHSLRLLDSVSRLQGVSDQSFQVEEAKRIKQKADSLSSLVTRHMDEFKRT 895

Query: 857  EESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLTDPDTDAATIQEVSEAV 916
            +++    +  AQ+L     + R + ++ + R  L   + ++ L+  +     ++ + + +
Sbjct: 896  QKNLGNWKEEAQQLLQNGKSGREKSDQLLSRANLAKSRAQEALSMGNATFYEVESILKNL 955

Query: 917  LALWLPTDS--ATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARARRLQAEAEEARSRAH 974
                L  D+  A   + M  +  I+ ++ +      Q ++ +  A      A+     A 
Sbjct: 956  REFDLQVDNRKAEAEEAMKRLSYISQKVSDASDKTQQAERALGSAAADAQRAKNGAGEAL 1015

Query: 975  AVEGQVEDVVGNLRQGTVALQEAQDTMQGT---SRSLRLIQDRVAEVQQVLRPAEKLVTS 1031
             +  ++E  +G+L        EA  T  G     + L  ++  + EV+  L   E    +
Sbjct: 1016 EISSEIEQEIGSLN------LEANVTADGALAMEKGLASLKSEMREVEGELERKELEFDT 1069

Query: 1032 MTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEG---ASEQALSA-QEGFERIKQKYAE 1087
                +    T  +++  +A+  G          +G     +Q LS  +EG   ++QK + 
Sbjct: 1070 NMDAVQMVITEAQKVDTRAKNAGVTIQDTLNTLDGLLHLMDQPLSVDEEGLVLLEQKLSR 1129

Query: 1088 LKDRL 1092
             K ++
Sbjct: 1130 AKTQI 1134



 Score =  124 bits (312), Expect = 4e-28
 Identities = 71/183 (38%), Positives = 99/183 (54%), Gaps = 26/183 (14%)

Query: 316 CDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQET 375
           CDCNG S  C FD  +    Q   G  C NC D+T+G +CE+C+  ++R+R      ++ 
Sbjct: 28  CDCNGKSRQCIFDRELHR--QTGNGFRCLNCNDNTDGIHCEKCKNGFYRHRE-----RDR 80

Query: 376 CISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGC------- 428
           C+ C C+  G++  A CD  +G+C CK  V G RCD C PGF  LT A   GC       
Sbjct: 81  CLPCNCNSKGSL-SARCDN-SGRCSCKPGVTGARCDRCLPGFHMLTDA---GCTQDQRLL 135

Query: 429 -HRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASG--QGCEPCACDP 485
             +CDC+  G     PCD  +GRC+C P V G +CD+C   ++ L  G  +GC  C C  
Sbjct: 136 DSKCDCDPAGIAG--PCD--AGRCVCKPAVTGERCDRCRSGYYNLDGGNPEGCTQCFCYG 191

Query: 486 HNS 488
           H++
Sbjct: 192 HSA 194



 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 52/159 (32%), Positives = 71/159 (44%), Gaps = 31/159 (19%)

Query: 281 CQHNTAGPNCERCAP-FYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAY 339
           C  NT G +CE+C   FY +R        +   C  C+CN               S+G+ 
Sbjct: 56  CNDNTDGIHCEKCKNGFYRHR--------ERDRCLPCNCN---------------SKGSL 92

Query: 340 GGVCDN-----CRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCDP 394
              CDN     C+    G  C+RC   +      G +  +  +  +CD D A    PCD 
Sbjct: 93  SARCDNSGRCSCKPGVTGARCDRCLPGFHMLTDAGCTQDQRLLDSKCDCDPAGIAGPCD- 151

Query: 395 VTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDC 433
             G+CVCK  V GERCD C+ G+  L   NP+GC +C C
Sbjct: 152 -AGRCVCKPAVTGERCDRCRSGYYNLDGGNPEGCTQCFC 189



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 56/159 (35%), Positives = 74/159 (46%), Gaps = 27/159 (16%)

Query: 431 CDCNILGSRRDMPCDEE-------SGRCL-CLPNVVGPKCDQCAPYHWKLASGQGCEPCA 482
           CDCN  G  R    D E         RCL C  N  G  C++C    ++      C PC 
Sbjct: 28  CDCN--GKSRQCIFDRELHRQTGNGFRCLNCNDNTDGIHCEKCKNGFYRHRERDRCLPCN 85

Query: 483 CDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRA--------C 534
           C+   SLS +C+  +G+C C+ G  G  C      +C    +     GC          C
Sbjct: 86  CNSKGSLSARCDN-SGRCSCKPGVTGARCD-----RCLPGFHMLTDAGCTQDQRLLDSKC 139

Query: 535 DCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCN 573
           DCD  G  GP CD  +GRC+C+P +TG RCD+C+ GY N
Sbjct: 140 DCDPAGIAGP-CD--AGRCVCKPAVTGERCDRCRSGYYN 175



 Score = 77.8 bits (190), Expect = 6e-14
 Identities = 71/247 (28%), Positives = 93/247 (37%), Gaps = 42/247 (17%)

Query: 259 CAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDC 318
           C  + G +  P T       C          C  C   + N P       D   C+ C C
Sbjct: 416 CNCQGGGACDPDTGD-----CYSGDENPDIECADCPIGFYNDP------HDPRSCKPCPC 464

Query: 319 -NGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCI 377
            NG S  C   P            VC+NC     G  CE C   YF +          C 
Sbjct: 465 HNGFS--CSVMPETEEV-------VCNNCPPGVTGARCELCADGYFGDPFGEHGPVRPCQ 515

Query: 378 SCECDPDGAVPGAP--CDPVTGQCV-CKEHVQGERCDLCKPGFTGLTYA-NP-QGCHRCD 432
            C+C+ +   P A   CD +TG+C+ C  +  G  CD CK G+ G   A NP   C  C+
Sbjct: 516 PCQCN-NNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQCKAGYFGDPLAPNPADKCRACN 574

Query: 433 CNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQ 492
           CN +GS   + C    G C+C P   GP C+  A           C  C    +N +  Q
Sbjct: 575 CNPMGS-EPVGC-RSDGTCVCKPGFGGPNCEHGA---------FSCPAC----YNQVKIQ 619

Query: 493 CNQFTGQ 499
            +QF  Q
Sbjct: 620 MDQFMQQ 626



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 23/68 (33%), Positives = 31/68 (45%), Gaps = 9/68 (13%)

Query: 258 RCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCD 317
           +C   P   AGP  A +    CVC+    G  C+RC   Y N      +G +   C +C 
Sbjct: 138 KCDCDPAGIAGPCDAGR----CVCKPAVTGERCDRCRSGYYN-----LDGGNPEGCTQCF 188

Query: 318 CNGHSETC 325
           C GHS +C
Sbjct: 189 CYGHSASC 196



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 35/134 (26%), Positives = 46/134 (34%), Gaps = 24/134 (17%)

Query: 253 HGHADRCAPKPGASAGPSTA-VQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAH 311
           H   DRC P    S G  +A       C C+    G  C+RC P ++             
Sbjct: 75  HRERDRCLPCNCNSKGSLSARCDNSGRCSCKPGVTGARCDRCLPGFHMLTDAGCTQDQRL 134

Query: 312 ECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDN----CRDHTEGKNCERCQLHYFRNRR 367
              +CDC         DPA  A       G CD     C+    G+ C+RC+  Y+    
Sbjct: 135 LDSKCDC---------DPAGIA-------GPCDAGRCVCKPAVTGERCDRCRSGYY---N 175

Query: 368 PGASIQETCISCEC 381
                 E C  C C
Sbjct: 176 LDGGNPEGCTQCFC 189


>gi|157419140 laminin, gamma 2 isoform b precursor [Homo sapiens]
          Length = 1111

 Score =  135 bits (340), Expect = 2e-31
 Identities = 158/731 (21%), Positives = 288/731 (39%), Gaps = 84/731 (11%)

Query: 351  EGKNCERCQLHYFRNRRPGASIQE--TCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGE 408
            +G+ C+ C   Y   +R  A +    TCI C C   GA     CDP TG C   +     
Sbjct: 389  KGQFCQDCASGY---KRDSARLGPFGTCIPCNCQGGGA-----CDPDTGDCYSGDENPDI 440

Query: 409  RCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPY 468
             C  C  GF    + +P+ C  C C+   S   MP  EE     C P V G +C+ CA  
Sbjct: 441  ECADCPIGFYNDPH-DPRSCKPCPCHNGFSCSVMPETEEVVCNNCPPGVTGARCELCADG 499

Query: 469  HWKLASGQ-----GCEPCACDPH--NSLSPQCNQFTGQC-PCREGFGGLMCSAAAIRQCP 520
            ++    G+      C+PC C+ +   S S  C++ TG+C  C     G+ C         
Sbjct: 500  YFGDPFGEHGPVRPCQPCQCNNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQCKAGYFG 559

Query: 521  DRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVA 580
            D    + A  CRAC+C+  G+E  GC ++ G C+C+PG  GP C+              +
Sbjct: 560  DPLAPNPADKCRACNCNPMGSEPVGC-RSDGTCVCKPGFGGPNCEH----------GAFS 608

Query: 581  CHPCFQTYDADLREQALRFGRLRNATASLWSGPG-LEDRGLASRILDAKSKIEQI--RAV 637
            C  C+      + +   +  R+    +    G G + D  L  R+  A+  ++ I   A 
Sbjct: 609  CPACYNQVKIQMDQFMQQLQRMEALISKAQGGDGVVPDTELEGRMQQAEQALQDILRDAQ 668

Query: 638  LSSPAVTE--QEVAQVASAILSLRRTLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTM 695
            +S  A      ++A+V S   S +  L  L++ +   E   +L    ++  R  + L+T 
Sbjct: 669  ISEGASRSLGLQLAKVRSQENSYQSRLDDLKMTV---ERVRALGSQYQNRVRDTHRLITQ 725

Query: 696  YQRKREQFE------KISSAD----PSGAFRMLSTAYEQSAQAAQQVSDSSRLLDQLRDS 745
             Q    + E       I ++D    P+G   +   A   +    +  S+  +L  +  D 
Sbjct: 726  MQLSLAESEASLGNTNIPASDHYVGPNGFKSLAQEATRLAESHVESASNMEQLTRETEDY 785

Query: 746  RREAERLVRQA---GGGGGTGSPKLVALRLEMSSLPDLTPTFNKLCGNSRQMACTPISCP 802
             ++A  LVR+A   G G G+GSP    ++  +  L        +L   + Q         
Sbjct: 786  SKQALSLVRKALHEGVGSGSGSPDGAVVQGLVEKLEKTKSLAQQLTREATQAE------- 838

Query: 803  GELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR------GFNAQLQRTRQMIRAA 856
                  D       R    + R  G    + QV E  R        ++ + R     +  
Sbjct: 839  ---IEADRSYQHSLRLLDSVSRLQGVSDQSFQVEEAKRIKQKADSLSSLVTRHMDEFKRT 895

Query: 857  EESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLTDPDTDAATIQEVSEAV 916
            +++    +  AQ+L     + R + ++ + R  L   + ++ L+  +     ++ + + +
Sbjct: 896  QKNLGNWKEEAQQLLQNGKSGREKSDQLLSRANLAKSRAQEALSMGNATFYEVESILKNL 955

Query: 917  LALWLPTDS--ATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARARRLQAEAEEARSRAH 974
                L  D+  A   + M  +  I+ ++ +      Q ++ +  A      A+     A 
Sbjct: 956  REFDLQVDNRKAEAEEAMKRLSYISQKVSDASDKTQQAERALGSAAADAQRAKNGAGEAL 1015

Query: 975  AVEGQVEDVVGNLR-------QGTVALQEAQDTMQGTSRSLRLIQDR--------VAEVQ 1019
             +  ++E  +G+L         G +A+++   +++   R +    +R        +  VQ
Sbjct: 1016 EISSEIEQEIGSLNLEANVTADGALAMEKGLASLKSEMREVEGELERKELEFDTNMDAVQ 1075

Query: 1020 QVLRPAEKLVT 1030
             V+  A+K+ T
Sbjct: 1076 MVITEAQKVDT 1086



 Score =  124 bits (312), Expect = 4e-28
 Identities = 71/183 (38%), Positives = 99/183 (54%), Gaps = 26/183 (14%)

Query: 316 CDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQET 375
           CDCNG S  C FD  +    Q   G  C NC D+T+G +CE+C+  ++R+R      ++ 
Sbjct: 28  CDCNGKSRQCIFDRELHR--QTGNGFRCLNCNDNTDGIHCEKCKNGFYRHRE-----RDR 80

Query: 376 CISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGC------- 428
           C+ C C+  G++  A CD  +G+C CK  V G RCD C PGF  LT A   GC       
Sbjct: 81  CLPCNCNSKGSL-SARCDN-SGRCSCKPGVTGARCDRCLPGFHMLTDA---GCTQDQRLL 135

Query: 429 -HRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASG--QGCEPCACDP 485
             +CDC+  G     PCD  +GRC+C P V G +CD+C   ++ L  G  +GC  C C  
Sbjct: 136 DSKCDCDPAGIAG--PCD--AGRCVCKPAVTGERCDRCRSGYYNLDGGNPEGCTQCFCYG 191

Query: 486 HNS 488
           H++
Sbjct: 192 HSA 194



 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 52/159 (32%), Positives = 71/159 (44%), Gaps = 31/159 (19%)

Query: 281 CQHNTAGPNCERCAP-FYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAY 339
           C  NT G +CE+C   FY +R        +   C  C+CN               S+G+ 
Sbjct: 56  CNDNTDGIHCEKCKNGFYRHR--------ERDRCLPCNCN---------------SKGSL 92

Query: 340 GGVCDN-----CRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCDP 394
              CDN     C+    G  C+RC   +      G +  +  +  +CD D A    PCD 
Sbjct: 93  SARCDNSGRCSCKPGVTGARCDRCLPGFHMLTDAGCTQDQRLLDSKCDCDPAGIAGPCD- 151

Query: 395 VTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDC 433
             G+CVCK  V GERCD C+ G+  L   NP+GC +C C
Sbjct: 152 -AGRCVCKPAVTGERCDRCRSGYYNLDGGNPEGCTQCFC 189



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 56/159 (35%), Positives = 74/159 (46%), Gaps = 27/159 (16%)

Query: 431 CDCNILGSRRDMPCDEE-------SGRCL-CLPNVVGPKCDQCAPYHWKLASGQGCEPCA 482
           CDCN  G  R    D E         RCL C  N  G  C++C    ++      C PC 
Sbjct: 28  CDCN--GKSRQCIFDRELHRQTGNGFRCLNCNDNTDGIHCEKCKNGFYRHRERDRCLPCN 85

Query: 483 CDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRA--------C 534
           C+   SLS +C+  +G+C C+ G  G  C      +C    +     GC          C
Sbjct: 86  CNSKGSLSARCDN-SGRCSCKPGVTGARCD-----RCLPGFHMLTDAGCTQDQRLLDSKC 139

Query: 535 DCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCN 573
           DCD  G  GP CD  +GRC+C+P +TG RCD+C+ GY N
Sbjct: 140 DCDPAGIAGP-CD--AGRCVCKPAVTGERCDRCRSGYYN 175



 Score = 77.8 bits (190), Expect = 6e-14
 Identities = 71/247 (28%), Positives = 93/247 (37%), Gaps = 42/247 (17%)

Query: 259 CAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDC 318
           C  + G +  P T       C          C  C   + N P       D   C+ C C
Sbjct: 416 CNCQGGGACDPDTGD-----CYSGDENPDIECADCPIGFYNDP------HDPRSCKPCPC 464

Query: 319 -NGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCI 377
            NG S  C   P            VC+NC     G  CE C   YF +          C 
Sbjct: 465 HNGFS--CSVMPETEEV-------VCNNCPPGVTGARCELCADGYFGDPFGEHGPVRPCQ 515

Query: 378 SCECDPDGAVPGAP--CDPVTGQCV-CKEHVQGERCDLCKPGFTGLTYA-NP-QGCHRCD 432
            C+C+ +   P A   CD +TG+C+ C  +  G  CD CK G+ G   A NP   C  C+
Sbjct: 516 PCQCN-NNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQCKAGYFGDPLAPNPADKCRACN 574

Query: 433 CNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQ 492
           CN +GS   + C    G C+C P   GP C+  A           C  C    +N +  Q
Sbjct: 575 CNPMGS-EPVGC-RSDGTCVCKPGFGGPNCEHGA---------FSCPAC----YNQVKIQ 619

Query: 493 CNQFTGQ 499
            +QF  Q
Sbjct: 620 MDQFMQQ 626



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 23/68 (33%), Positives = 31/68 (45%), Gaps = 9/68 (13%)

Query: 258 RCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCD 317
           +C   P   AGP  A +    CVC+    G  C+RC   Y N      +G +   C +C 
Sbjct: 138 KCDCDPAGIAGPCDAGR----CVCKPAVTGERCDRCRSGYYN-----LDGGNPEGCTQCF 188

Query: 318 CNGHSETC 325
           C GHS +C
Sbjct: 189 CYGHSASC 196



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 35/134 (26%), Positives = 46/134 (34%), Gaps = 24/134 (17%)

Query: 253 HGHADRCAPKPGASAGPSTA-VQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAH 311
           H   DRC P    S G  +A       C C+    G  C+RC P ++             
Sbjct: 75  HRERDRCLPCNCNSKGSLSARCDNSGRCSCKPGVTGARCDRCLPGFHMLTDAGCTQDQRL 134

Query: 312 ECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDN----CRDHTEGKNCERCQLHYFRNRR 367
              +CDC         DPA  A       G CD     C+    G+ C+RC+  Y+    
Sbjct: 135 LDSKCDC---------DPAGIA-------GPCDAGRCVCKPAVTGERCDRCRSGYY---N 175

Query: 368 PGASIQETCISCEC 381
                 E C  C C
Sbjct: 176 LDGGNPEGCTQCFC 189


>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
          Length = 4391

 Score =  120 bits (302), Expect = 6e-27
 Identities = 69/194 (35%), Positives = 88/194 (45%), Gaps = 35/194 (18%)

Query: 250  CFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQD 309
            C CHGH++ C P+ GA  G            CQH+T GP CE+C P Y    +  A+   
Sbjct: 1159 CSCHGHSEACEPETGACQG------------CQHHTEGPRCEQCQPGY----YGDAQRGT 1202

Query: 310  AHECQRCDCNGHSETCHFDPAVFAASQGAY-----GGVCDNCRDHTEGKNCERCQLHYFR 364
              +CQ C C G       DPA   A+   +        CD C     G++CERC   Y+ 
Sbjct: 1203 PQDCQLCPCYG-------DPAAGQAAHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYG 1255

Query: 365  NRRPGASIQETC-----ISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTG 419
            N   G   Q        I C CDP G+V  + CD   GQC CK  V+G  C  C+P    
Sbjct: 1256 NPSQGQPCQRDSQVPGPIGCNCDPQGSV-SSQCD-AAGQCQCKAQVEGLTCSHCRPHHFH 1313

Query: 420  LTYANPQGCHRCDC 433
            L+ +NP GC  C C
Sbjct: 1314 LSASNPDGCLPCFC 1327



 Score =  110 bits (274), Expect = 1e-23
 Identities = 74/236 (31%), Positives = 97/236 (41%), Gaps = 44/236 (18%)

Query: 268  GPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHF 327
            G   A++V   C C     GP+C+ C   Y   P     G     C+RC C+GHSE C  
Sbjct: 1116 GQDPALEVEQ-CSCPPGYRGPSCQDCDTGYTRTP----SGLYLGTCERCSCHGHSEACEP 1170

Query: 328  DPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCEC--DPDG 385
            +            G C  C+ HTEG  CE+CQ  Y+ + + G    + C  C C  DP  
Sbjct: 1171 ET-----------GACQGCQHHTEGPRCEQCQPGYYGDAQRGT--PQDCQLCPCYGDPAA 1217

Query: 386  AVPGAPC----DPVTGQCVCKEHVQGERCDLCKPGFTGLTYANP---QGCHR-------- 430
                  C    D       C     G  C+ C PG+    Y NP   Q C R        
Sbjct: 1218 GQAAHTCFLDTDGHPTCDACSPGHSGRHCERCAPGY----YGNPSQGQPCQRDSQVPGPI 1273

Query: 431  -CDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASG--QGCEPCAC 483
             C+C+  GS     CD  +G+C C   V G  C  C P+H+ L++    GC PC C
Sbjct: 1274 GCNCDPQGSVSSQ-CD-AAGQCQCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFC 1327



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 65/218 (29%), Positives = 86/218 (39%), Gaps = 43/218 (19%)

Query: 345  NCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCV-CKE 403
            +C     G +C+ C   Y   R P      TC  C C          C+P TG C  C+ 
Sbjct: 1127 SCPPGYRGPSCQDCDTGY--TRTPSGLYLGTCERCSCHGHSEA----CEPETGACQGCQH 1180

Query: 404  HVQGERCDLCKPGFTG-LTYANPQGCHRCDCNILGSRRDMPCDEESGRCL---------- 452
            H +G RC+ C+PG+ G      PQ C  C C       D    + +  C           
Sbjct: 1181 HTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCY-----GDPAAGQAAHTCFLDTDGHPTCD 1235

Query: 453  -CLPNVVGPKCDQCAP-YHWKLASGQGCEP---------CACDPHNSLSPQCNQFTGQCP 501
             C P   G  C++CAP Y+   + GQ C+          C CDP  S+S QC+   GQC 
Sbjct: 1236 ACSPGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQCDA-AGQCQ 1294

Query: 502  CREGFGGLMCSAAAIRQCPDRTYGDVAT---GCRACDC 536
            C+    GL CS      C    +   A+   GC  C C
Sbjct: 1295 CKAQVEGLTCS-----HCRPHHFHLSASNPDGCLPCFC 1327



 Score = 87.0 bits (214), Expect = 9e-17
 Identities = 61/222 (27%), Positives = 83/222 (37%), Gaps = 43/222 (19%)

Query: 279 CVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGA 338
           C C    +G +CE C   +   P  P  G     C  C+CNGH+ +C  DP         
Sbjct: 731 CRCPIGYSGLSCESCDAHFTRVPGGPYLGT----CSGCNCNGHASSC--DPVY------- 777

Query: 339 YGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCEC---------------DP 383
             G C NC+ +TEG  C +C+  +F +     +   +C  C C               D 
Sbjct: 778 --GHCLNCQHNTEGPQCNKCKAGFFGDAMKATA--TSCRPCPCPYIDASRRFSDTCFLDT 833

Query: 384 DGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMP 443
           DG    A CD       C     G RC+ C PG+ G        C   +  I+       
Sbjct: 834 DGQ---ATCD------ACAPGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGS 884

Query: 444 CDEESGRCLCLPNVVGPKCDQCA--PYHWKLASGQGCEPCAC 483
                  C C  NVVG  C++CA   +H    +  GC  C C
Sbjct: 885 MGTSGEACRCKNNVVGRLCNECADGSFHLSTRNPDGCLKCFC 926



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 58/189 (30%), Positives = 78/189 (41%), Gaps = 31/189 (16%)

Query: 250 CFCHGHADRCAPKPGASAGPSTAVQVHDVCV-CQHNTAGPNCERC-APFYNNRPWRPAEG 307
           C C+GHA  C P             V+  C+ CQHNT GP C +C A F+ +     A  
Sbjct: 764 CNCNGHASSCDP-------------VYGHCLNCQHNTEGPQCNKCKAGFFGD-----AMK 805

Query: 308 QDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNR- 366
             A  C+ C C     +  F    F  + G     CD C     G+ CE C   Y  N  
Sbjct: 806 ATATSCRPCPCPYIDASRRFSDTCFLDTDGQ--ATCDACAPGYTGRRCESCAPGYEGNPI 863

Query: 367 RPGASIQETCISC-ECDPDGAVPGAPCDPVTGQ-CVCKEHVQGERCDLCKPGFTGLTYAN 424
           +PG   +        CD  G++        +G+ C CK +V G  C+ C  G   L+  N
Sbjct: 864 QPGGKCRPVNQEIVRCDERGSMG------TSGEACRCKNNVVGRLCNECADGSFHLSTRN 917

Query: 425 PQGCHRCDC 433
           P GC +C C
Sbjct: 918 PDGCLKCFC 926



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 53/190 (27%), Positives = 76/190 (40%), Gaps = 36/190 (18%)

Query: 265  ASAGPSTAVQVHDV--CVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHS 322
            A  GPS   +  +V  C C     G +C+ CAP Y     R   G     C+ C+CNGHS
Sbjct: 1514 AQPGPSNRPRALEVEECRCPPGYIGLSCQDCAPGYT----RTGSGLYLGHCELCECNGHS 1569

Query: 323  ETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECD 382
            + CH +            G C  C+ +  G+ CE C   Y+ +   G    E C  C C 
Sbjct: 1570 DLCHPET-----------GACSQCQHNAAGEFCELCAPGYYGDATAGT--PEDCQPCAC- 1615

Query: 383  PDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDM 442
                 P    + +  +        G RC  C+PG+TG      Q C +C    +G+    
Sbjct: 1616 -----PLTNPENMFSRTCESLGAGGYRCTACEPGYTG------QYCEQCGPGYVGNP--- 1661

Query: 443  PCDEESGRCL 452
                + G+CL
Sbjct: 1662 --SVQGGQCL 1669



 Score = 70.5 bits (171), Expect = 9e-12
 Identities = 51/166 (30%), Positives = 63/166 (37%), Gaps = 37/166 (22%)

Query: 447  ESGRCLCLPNVVGPKCDQCAPYHWKLASG---QGCEPCACDPHNSLSPQCNQFTGQC-PC 502
            E   C C P  +G  C  CAP + +  SG     CE C C+ H+ L   C+  TG C  C
Sbjct: 1526 EVEECRCPPGYIGLSCQDCAPGYTRTGSGLYLGHCELCECNGHSDL---CHPETGACSQC 1582

Query: 503  REGFGGLMCSAAAIRQCPDRTYGDVATG----CRACDCDFRGTE---GPGCDKASG---R 552
            +    G  C       C    YGD   G    C+ C C     E      C+       R
Sbjct: 1583 QHNAAGEFCEL-----CAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYR 1637

Query: 553  C-LCRPGLTGPRCDQCQRGY--------------CNRYPVCVACHP 583
            C  C PG TG  C+QC  GY               N+ P+ V  HP
Sbjct: 1638 CTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVEVHP 1683



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 42/122 (34%), Positives = 50/122 (40%), Gaps = 30/122 (24%)

Query: 250  CFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQD 309
            C C+GH+D C P+ GA +             CQHN AG  CE CAP Y    +  A    
Sbjct: 1563 CECNGHSDLCHPETGACS------------QCQHNAAGEFCELCAPGY----YGDATAGT 1606

Query: 310  AHECQRCDC------NGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYF 363
              +CQ C C      N  S TC         S GA G  C  C     G+ CE+C   Y 
Sbjct: 1607 PEDCQPCACPLTNPENMFSRTCE--------SLGAGGYRCTACEPGYTGQYCEQCGPGYV 1658

Query: 364  RN 365
             N
Sbjct: 1659 GN 1660



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 50/169 (29%), Positives = 64/169 (37%), Gaps = 43/169 (25%)

Query: 432  DCNILGSRRDMPCDEESGR--------CLCLPNVVGPKCDQCAPYHWKLASG---QGCEP 480
            +  + G   D+   EE+G+        C C P   GP C  C   + +  SG     CE 
Sbjct: 1099 ESRVSGISMDVAVPEETGQDPALEVEQCSCPPGYRGPSCQDCDTGYTRTPSGLYLGTCER 1158

Query: 481  CACDPHNSLSPQCNQFTGQCP-CREGFGGLMCSAAAIRQCPDRTYGDVATG----CRACD 535
            C+C  H   S  C   TG C  C+    G  C      QC    YGD   G    C+ C 
Sbjct: 1159 CSCHGH---SEACEPETGACQGCQHHTEGPRC-----EQCQPGYYGDAQRGTPQDCQLCP 1210

Query: 536  C------------DFRGTEG-PGCDKASGRCLCRPGLTGPRCDQCQRGY 571
            C             F  T+G P CD       C PG +G  C++C  GY
Sbjct: 1211 CYGDPAAGQAAHTCFLDTDGHPTCD------ACSPGHSGRHCERCAPGY 1253



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 63/233 (27%), Positives = 87/233 (37%), Gaps = 42/233 (18%)

Query: 398 QCVCKEHVQGERCDLCKPGFTGLTYANPQG-CHRCDCNILGSRRDMPCDEESGRCL-CLP 455
           +C C     G  C+ C   FT +      G C  C+CN   S     CD   G CL C  
Sbjct: 730 ECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASS----CDPVYGHCLNCQH 785

Query: 456 NVVGPKCDQCAPYHW---KLASGQGCEPCAC---DPHNSLSPQCNQFT-GQCPC---REG 505
           N  GP+C++C    +     A+   C PC C   D     S  C   T GQ  C     G
Sbjct: 786 NTEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPG 845

Query: 506 FGGLMCSAAAIRQCPDRTYGDVATG--CRACD-----CDFRGTEGPGCDKASGRCLCRPG 558
           + G  C + A    P      +  G  CR  +     CD RG+ G   +     C C+  
Sbjct: 846 YTGRRCESCA----PGYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGEA----CRCKNN 897

Query: 559 LTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFGRLRNATASLWS 611
           + G  C++C  G  +             T + D   +    G  R+ T+S WS
Sbjct: 898 VVGRLCNECADGSFH-----------LSTRNPDGCLKCFCMGVSRHCTSSSWS 939



 Score = 40.4 bits (93), Expect = 0.010
 Identities = 26/89 (29%), Positives = 32/89 (35%), Gaps = 20/89 (22%)

Query: 480  PCACDP--HNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCD 537
            PC   P  H +      ++  QC CR+GF G +C                        C 
Sbjct: 4107 PCERQPCQHGATCMPAGEYEFQCLCRDGFKGDLCEH------------------EENPCQ 4148

Query: 538  FRGTEGPGCDKASGRCLCRPGLTGPRCDQ 566
             R     G      RCLC PG +GPRC Q
Sbjct: 4149 LREPCLHGGTCQGTRCLCLPGFSGPRCQQ 4177



 Score = 33.9 bits (76), Expect = 0.93
 Identities = 26/90 (28%), Positives = 37/90 (41%), Gaps = 20/90 (22%)

Query: 378  SCECDPDGAVPGAPCDPVTG---QCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCN 434
            S  C+      GA C P      QC+C++  +G+ C+            NP  C   +  
Sbjct: 4105 SSPCERQPCQHGATCMPAGEYEFQCLCRDGFKGDLCE---------HEENP--CQLREPC 4153

Query: 435  ILGSRRDMPCDEESGRCLCLPNVVGPKCDQ 464
            + G      C  +  RCLCLP   GP+C Q
Sbjct: 4154 LHGGT----C--QGTRCLCLPGFSGPRCQQ 4177



 Score = 31.2 bits (69), Expect = 6.1
 Identities = 20/68 (29%), Positives = 28/68 (41%), Gaps = 10/68 (14%)

Query: 506  FGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCD 565
            F  L  +A  I  CP          CR   C   G +    + +S  C+C  G TG RC+
Sbjct: 3832 FHDLNLTAHGISHCPT---------CRDRPCQ-NGGQCHDSESSSYVCVCPAGFTGSRCE 3881

Query: 566  QCQRGYCN 573
              Q  +C+
Sbjct: 3882 HSQALHCH 3889


>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
          Length = 1541

 Score =  116 bits (290), Expect = 1e-25
 Identities = 98/325 (30%), Positives = 123/325 (37%), Gaps = 64/325 (19%)

Query: 274 QVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQ-------RCD--------- 317
           +++  C+C     G  C    P     PW    G  + ECQ        CD         
Sbjct: 621 RLYGACLCDPGLYGRFCHLTCP-----PWAFGPGC-SEECQCVQPHTQSCDKRDGSCSCK 674

Query: 318 -------CNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGA 370
                  C    E  +F P  + A     G  CD+      G+  +RC    F+    G 
Sbjct: 675 AGFRGERCQAECELGYFGPGCWQACTCPVGVACDS----VSGECGKRCPAG-FQGEDCGQ 729

Query: 371 SIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDL-CKPGFTGLTYANPQGCH 429
                     C    +  GAPC  VTGQC C     GE C+  C  G  GL      GC 
Sbjct: 730 ECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEADCPEGRWGL------GCQ 783

Query: 430 R-CDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNS 488
             C      +R    CD E+G CLCLP  VG +C    P  W   S Q    CA D H  
Sbjct: 784 EICPACQHAAR----CDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCSCANDGH-- 837

Query: 489 LSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPG-CD 547
               C+  TG C C  G+ G  C     R C    +G   +    C+C    + G G CD
Sbjct: 838 ----CHPATGHCSCAPGWTGFSCQ----RACDTGHWGPDCS--HPCNC----SAGHGSCD 883

Query: 548 KASGRCLCRPGLTGPRCD-QCQRGY 571
             SG CLC  G  GPRC+ QC +G+
Sbjct: 884 AISGLCLCEAGYVGPRCEQQCPQGH 908



 Score =  114 bits (286), Expect = 4e-25
 Identities = 107/394 (27%), Positives = 141/394 (35%), Gaps = 94/394 (23%)

Query: 256  ADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHEC-Q 314
            A RC+  PGA+    T       C C     G  CE+  P           G    +C Q
Sbjct: 1129 AQRCSCPPGAACHHVTGA-----CRCPPGFTGSGCEQACP----------PGSFGEDCAQ 1173

Query: 315  RCDCNGHSETCHFDPAVFAASQGAYGGVCDN-CRDHTEGKNCER---------CQLHYFR 364
             C C G +  CH      + + G +G  C   C     G  CE+         C      
Sbjct: 1174 MCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGA 1233

Query: 365  NRRP----GASIQETCISCECDPD-----GAVPGAPCDPVTGQCVCKEHVQGERCDL--- 412
             R P    G     TC      P+     G   GA CDPVTG C+C     G RC+    
Sbjct: 1234 CRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCP 1293

Query: 413  ----------------------------CKPGFTG--LTYANPQGCHRCDCNILGS-RRD 441
                                        C  G+TG     A P G +   C++  S   +
Sbjct: 1294 QNRFGVGCEHTCSCRNGGLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNN 1353

Query: 442  MPCDEESGRCLCLPNVVGPKCDQCAP--YHWKLASGQGCEPCACDPHNSLSPQCNQFTGQ 499
              C+  +G C C P   G  C+   P  +H     G GC+      H +    C+  +G+
Sbjct: 1354 STCEPATGTCRCGPGFYGQACEHPCPPGFH-----GAGCQGLCWCQHGA---PCDPISGR 1405

Query: 500  CPCREGFGGLMCSAAAIRQCPDRTYGDVATGC-RACDCDFRGTEGPGCDKASGRCLCRPG 558
            C C  GF G  C     R C   ++G+   GC + CDCD     G  CD  +G CLC PG
Sbjct: 1406 CLCPAGFHGHFCE----RGCEPGSFGE---GCHQRCDCD----GGAPCDPVTGLCLCPPG 1454

Query: 559  LTGPRCD-QCQRGYCNRYPVCVACHPCFQTYDAD 591
             +G  C+  C+RG     P C     C    D D
Sbjct: 1455 RSGATCNLDCRRGQFG--PSCTLHCDCGGGADCD 1486



 Score =  107 bits (266), Expect = 9e-23
 Identities = 94/335 (28%), Positives = 121/335 (36%), Gaps = 73/335 (21%)

Query: 259  CAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHEC-QRCD 317
            C+     SAG  +   +  +C+C+    GP CE+  P          +G     C QRC 
Sbjct: 869  CSHPCNCSAGHGSCDAISGLCLCEAGYVGPRCEQQCP----------QGHFGPGCEQRCQ 918

Query: 318  CNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCI 377
            C  H   C           G  G  C++            C   +F     G   +  C 
Sbjct: 919  CQ-HGAACDHVSGACTCPAGWRGTFCEHA-----------CPAGFF-----GLDCRSAC- 960

Query: 378  SCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILG 437
                       GA CD V G C+C    +G RC    P     TY      H C      
Sbjct: 961  -------NCTAGAACDAVNGSCLCPAGRRGPRCAETCPAH---TYG-----HNCS-QACA 1004

Query: 438  SRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGC-EPCACDPHNSLSPQCNQF 496
                  CD   G+C C P  +GP C Q  P       G  C   C C    +    C+  
Sbjct: 1005 CFNGASCDPVHGQCHCAPGWMGPSCLQACPAG---LYGDNCRHSCLCQNGGT----CDPV 1057

Query: 497  TGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCR-ACDCDFRGTEGPGCDKASGRCLC 555
            +G C C EG+ GL C     ++C  R   DV  GCR +  C      G  CD  +GRCLC
Sbjct: 1058 SGHCACPEGWAGLACE----KECLPR---DVRAGCRHSGGC----LNGGLCDPHTGRCLC 1106

Query: 556  RPGLTGPRCDQ-CQRGY----CNRYPVC---VACH 582
              G TG +C   C RG+    C +   C    ACH
Sbjct: 1107 PAGWTGDKCQSPCLRGWFGEACAQRCSCPPGAACH 1141



 Score =  106 bits (265), Expect = 1e-22
 Identities = 98/332 (29%), Positives = 119/332 (35%), Gaps = 70/332 (21%)

Query: 266  SAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQR-CDCNGHSET 324
            S G +    V   C C     G +CE   P          EG+    CQ  C    H+  
Sbjct: 745  SCGGAPCHGVTGQCRCPPGRTGEDCEADCP----------EGRWGLGCQEICPACQHAAR 794

Query: 325  CHFDPAVFAASQGAYGGVC-DNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDP 383
            C  +        G  G  C D C     G +C+                      C C  
Sbjct: 795  CDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQT--------------------RCSCAN 834

Query: 384  DGAVPGAPCDPVTGQCVCKEHVQGERCD-LCKPGFTGLTYANPQGCHRCDCNILGSRRDM 442
            DG      C P TG C C     G  C   C  G  G     P   H C+C    S    
Sbjct: 835  DGH-----CHPATGHCSCAPGWTGFSCQRACDTGHWG-----PDCSHPCNC----SAGHG 880

Query: 443  PCDEESGRCLCLPNVVGPKCDQ-CAPYHWKLASGQGCEP-CACDPHNSLSPQCNQFTGQC 500
             CD  SG CLC    VGP+C+Q C   H+    G GCE  C C  H +    C+  +G C
Sbjct: 881  SCDAISGLCLCEAGYVGPRCEQQCPQGHF----GPGCEQRCQCQ-HGAA---CDHVSGAC 932

Query: 501  PCREGFGGLMCSAAAIRQCPDRTYGDVATGCR-ACDCDFRGTEGPGCDKASGRCLCRPGL 559
             C  G+ G  C  A    CP   +G     CR AC+C    T G  CD  +G CLC  G 
Sbjct: 933  TCPAGWRGTFCEHA----CPAGFFG---LDCRSACNC----TAGAACDAVNGSCLCPAGR 981

Query: 560  TGPRCDQCQRGYCNRYPVCVACHPCFQTYDAD 591
             GPRC +    +   +    AC  CF     D
Sbjct: 982  RGPRCAETCPAHTYGHNCSQAC-ACFNGASCD 1012



 Score =  105 bits (262), Expect = 3e-22
 Identities = 105/394 (26%), Positives = 135/394 (34%), Gaps = 114/394 (28%)

Query: 246  LQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPA 305
            + GSC C          P    GP  A        C  +T G NC +    +N     P 
Sbjct: 971  VNGSCLC----------PAGRRGPRCAE------TCPAHTYGHNCSQACACFNGASCDPV 1014

Query: 306  EGQDAHECQRCDCNGHSETCHFDPA------VFAASQGAYGGVCDNCRDHTEGKNCERCQ 359
             GQ                CH  P       + A   G YG   DNCR     +N   C 
Sbjct: 1015 HGQ----------------CHCAPGWMGPSCLQACPAGLYG---DNCRHSCLCQNGGTCD 1055

Query: 360  LHYFRNRRP----GASIQETCISCEC-----DPDGAVPGAPCDPVTGQCVCKEHVQGERC 410
                    P    G + ++ C+  +         G + G  CDP TG+C+C     G++C
Sbjct: 1056 PVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKC 1115

Query: 411  DL-CKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYH 469
               C  G+ G   A      RC C          C   +G C C P   G  C+Q  P  
Sbjct: 1116 QSPCLRGWFGEACAQ-----RCSCP-----PGAACHHVTGACRCPPGFTGSGCEQACPPG 1165

Query: 470  WKLASGQGC-EPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYG--- 525
               + G+ C + C C   N   P C+  TG C C  G+ G  C     ++CP   YG   
Sbjct: 1166 ---SFGEDCAQMCQCPGEN---PACHPATGTCSCAAGYHGPSCQ----QRCPPGRYGPGC 1215

Query: 526  ------------DVATGCRACDCDFRGTE----------------------GPGCDKASG 551
                        D ATG   C   F GT+                      G  CD  +G
Sbjct: 1216 EQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTG 1275

Query: 552  RCLCRPGLTGPRCDQCQRGYCNRYPVCVAC-HPC 584
             CLC PG  G R   C+RG C +    V C H C
Sbjct: 1276 TCLCPPGRAGVR---CERG-CPQNRFGVGCEHTC 1305



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 91/312 (29%), Positives = 114/312 (36%), Gaps = 76/312 (24%)

Query: 259  CAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQR-CD 317
            C    GA+  P T       C+C    AG  CER  P          + +    C+  C 
Sbjct: 1262 CGCGQGAACDPVTGT-----CLCPPGRAGVRCERGCP----------QNRFGVGCEHTCS 1306

Query: 318  CNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCE-RCQLHYFRNRRPGASIQETC 376
            C  +   CH           A  G C +C     G++CE  C         PG       
Sbjct: 1307 CR-NGGLCH-----------ASNGSC-SCGLGWTGRHCELACP--------PGRYGAACH 1345

Query: 377  ISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDL-CKPGFTGLTYANPQGCHRCDCNI 435
            + C C  +       C+P TG C C     G+ C+  C PGF G   A  QG   C    
Sbjct: 1346 LECSCHNNST-----CEPATGTCRCGPGFYGQACEHPCPPGFHG---AGCQGLCWC---- 1393

Query: 436  LGSRRDMPCDEESGRCLCLPNVVGPKCDQ-CAPYHWKLASGQGC-EPCACDPHNSLSPQC 493
               +   PCD  SGRCLC     G  C++ C P  +    G+GC + C CD        C
Sbjct: 1394 ---QHGAPCDPISGRCLCPAGFHGHFCERGCEPGSF----GEGCHQRCDCDG----GAPC 1442

Query: 494  NQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRA-CDCDFRGTEGPGCDKASGR 552
            +  TG C C  G  G  C+    R       G     C   CDC      G  CD  SG+
Sbjct: 1443 DPVTGLCLCPPGRSGATCNLDCRR-------GQFGPSCTLHCDCG----GGADCDPVSGQ 1491

Query: 553  CLCRPGLTGPRC 564
            C C  G  GP C
Sbjct: 1492 CHCVDGYMGPTC 1503



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 83/266 (31%), Positives = 100/266 (37%), Gaps = 64/266 (24%)

Query: 311 HECQ-RCDCNGHSETCHFDPAVFAASQGAYGGVC-DNCRDHTEGKNCERCQLHYFRNRRP 368
           H+C   CD   +  TC          +G  G +C + C   T GKNC             
Sbjct: 518 HDCSLTCDDCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCS------------ 565

Query: 369 GASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERC-DLCKPGFTGLTYANPQG 427
                    SC C   G      CD VTG C C   V G  C D C  G+ G      + 
Sbjct: 566 --------FSCSCQNGGT-----CDSVTGACRCPPGVSGTNCEDGCPKGYYG------KH 606

Query: 428 CH-RCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCD-QCAPYHWKLASGQGC-EPCAC- 483
           C  +C+C   G      C    G CLC P + G  C   C P+    A G GC E C C 
Sbjct: 607 CRKKCNCANRGR-----CHRLYGACLCDPGLYGRFCHLTCPPW----AFGPGCSEECQCV 657

Query: 484 DPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGC-RACDCDFRGTE 542
            PH   +  C++  G C C+ GF G  C A    +C     G    GC +AC C      
Sbjct: 658 QPH---TQSCDKRDGSCSCKAGFRGERCQA----EC---ELGYFGPGCWQACTCPV---- 703

Query: 543 GPGCDKASGRC--LCRPGLTGPRCDQ 566
           G  CD  SG C   C  G  G  C Q
Sbjct: 704 GVACDSVSGECGKRCPAGFQGEDCGQ 729



 Score = 64.7 bits (156), Expect = 5e-10
 Identities = 42/124 (33%), Positives = 59/124 (47%), Gaps = 17/124 (13%)

Query: 500 CPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGL 559
           C C EG+ GL+C+      CP  T+G   +   +C C   GT    CD  +G C C PG+
Sbjct: 540 CDCPEGWTGLICNET----CPPDTFGKNCSF--SCSCQNGGT----CDSVTGACRCPPGV 589

Query: 560 TGPRC-DQCQRGY----CNRYPVCVACHPCFQTYDADLREQALRFGRLRNATASLWS-GP 613
           +G  C D C +GY    C +   C     C + Y A L +  L +GR  + T   W+ GP
Sbjct: 590 SGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGL-YGRFCHLTCPPWAFGP 648

Query: 614 GLED 617
           G  +
Sbjct: 649 GCSE 652



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 62/244 (25%), Positives = 85/244 (34%), Gaps = 47/244 (19%)

Query: 373 QETCISCECDPDGAVPGAPCDPVTGQ-CVCKEHVQGERC----DLCKPGFTGLTY--ANP 425
           +E C+S EC       G  C P + Q C C    QG RC    D C+    G  +   N 
Sbjct: 120 EEGCLSAECSASLCFHGGRCVPGSAQPCHCPPGFQGPRCQYDVDECRTHNGGCQHRCVNT 179

Query: 426 QGCHRCDCN-----ILGSRRDM---PCDEESGRCL--CLPNVVGPKCDQCAPYHWKLASG 475
            G + C+C         SR  +    C   +G C   C+   +     QC P       G
Sbjct: 180 PGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDG 239

Query: 476 QGC---EPCACDPHNSLSPQCNQFTG--QCPCREGF----GGLMCS-----AAAIRQCPD 521
           + C    PCA + + S   +C    G  +C C  G+     G  C      AA + QC  
Sbjct: 240 RHCVRRSPCA-NRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQCAH 298

Query: 522 RTYGDVATGCRACDCDFR-GTEG-----------PGCDKASGRCL--CRPGLTGPRCDQC 567
                  +    C   +  G +G             C+  +G C   C     GP C  C
Sbjct: 299 GCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLC-TC 357

Query: 568 QRGY 571
            RGY
Sbjct: 358 PRGY 361


>gi|122937440 multiple EGF-like-domains 9 [Homo sapiens]
          Length = 639

 Score =  114 bits (285), Expect = 5e-25
 Identities = 72/211 (34%), Positives = 99/211 (46%), Gaps = 22/211 (10%)

Query: 379 CECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGS 438
           C C   G++    C+  TGQC C+   QG  C+ CK GF  L Y +   C  CDC+  G+
Sbjct: 241 CNCSVVGSLNVNRCNQTTGQCECRPGYQGLHCETCKEGFY-LNYTSGL-CQPCDCSPHGA 298

Query: 439 RRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTG 498
              +PC+  SG+C C   V+G  CD+C   ++   S  GC PC C   N+ S  C+  TG
Sbjct: 299 -LSIPCN-SSGKCQCKVGVIGSICDRCQDGYYGF-SKNGCLPCQC---NNRSASCDALTG 352

Query: 499 QC-PCREGFGGLMCSAA--AIRQCPDRTYGDVATGCRAC----DCDFRGTE-GPGCDKAS 550
            C  C+E   G  C        Q PD T   +   C A      C  + +E  P CD+  
Sbjct: 353 ACLNCQENSKGNHCEECKEGFYQSPDATKECLRCPCSAVTSTGSCSIKSSELEPECDQ-- 410

Query: 551 GRCLCRPGLTGPRCDQCQRGYCNRYPVCVAC 581
               C+ G  GP C++C+ GY N   +C  C
Sbjct: 411 ----CKDGYIGPNCNKCENGYYNFDSICRKC 437



 Score =  101 bits (252), Expect = 4e-21
 Identities = 53/189 (28%), Positives = 87/189 (46%), Gaps = 10/189 (5%)

Query: 397 GQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPN 456
           G+  C+ +++ +   L +P          +  + C+C+++GS     C++ +G+C C P 
Sbjct: 207 GKYACESNLKSKYLPLTQPVMNLRVSEAVKTEYVCNCSVVGSLNVNRCNQTTGQCECRPG 266

Query: 457 VVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAI 516
             G  C+ C    +   +   C+PC C PH +LS  CN  +G+C C+ G  G +C     
Sbjct: 267 YQGLHCETCKEGFYLNYTSGLCQPCDCSPHGALSIPCNS-SGKCQCKVGVIGSICD---- 321

Query: 517 RQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCL-CRPGLTGPRCDQCQRGYCNRY 575
            +C D  YG    GC  C C+ R      CD  +G CL C+    G  C++C+ G+    
Sbjct: 322 -RCQDGYYGFSKNGCLPCQCNNRSAS---CDALTGACLNCQENSKGNHCEECKEGFYQSP 377

Query: 576 PVCVACHPC 584
                C  C
Sbjct: 378 DATKECLRC 386



 Score =  101 bits (252), Expect = 4e-21
 Identities = 75/249 (30%), Positives = 107/249 (42%), Gaps = 47/249 (18%)

Query: 341 GVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCV 400
           G C+ CR   +G +CE C+  ++ N   G      C  C+C P GA+   PC+  +G+C 
Sbjct: 259 GQCE-CRPGYQGLHCETCKEGFYLNYTSG-----LCQPCDCSPHGAL-SIPCNS-SGKCQ 310

Query: 401 CKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCL-CLPNVVG 459
           CK  V G  CD C+ G+ G    +  GC  C CN     R   CD  +G CL C  N  G
Sbjct: 311 CKVGVIGSICDRCQDGYYGF---SKNGCLPCQCN----NRSASCDALTGACLNCQENSKG 363

Query: 460 PKCDQCAP-YHWKLASGQGCEPCACDPHNS----------LSPQCNQFTGQCPCREGFGG 508
             C++C   ++    + + C  C C    S          L P+C+Q      C++G+ G
Sbjct: 364 NHCEECKEGFYQSPDATKECLRCPCSAVTSTGSCSIKSSELEPECDQ------CKDGYIG 417

Query: 509 LMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPG-----CDKASGRCL-CRPGLTGP 562
             C+        +  Y +  + CR C C   G   P      C   SG C+ C    TG 
Sbjct: 418 PNCNKC------ENGYYNFDSICRKCQC--HGHVDPVKTPKICKPESGECINCLHNTTGF 469

Query: 563 RCDQCQRGY 571
            C+ C  GY
Sbjct: 470 WCENCLEGY 478



 Score = 77.8 bits (190), Expect = 6e-14
 Identities = 55/198 (27%), Positives = 80/198 (40%), Gaps = 43/198 (21%)

Query: 279 CVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGA 338
           C C+    G  C+RC   Y         G   + C  C CN  S +C            A
Sbjct: 309 CQCKVGVIGSICDRCQDGYY--------GFSKNGCLPCQCNNRSASCD-----------A 349

Query: 339 YGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQ 398
             G C NC+++++G +CE C+  ++++  P A+  + C+ C C    AV        TG 
Sbjct: 350 LTGACLNCQENSKGNHCEECKEGFYQS--PDAT--KECLRCPC---SAVTS------TGS 396

Query: 399 CVCKEHVQGERCDLCKPGFTGLT--------YANPQGCHRCDC--NILGSRRDMPCDEES 448
           C  K       CD CK G+ G          Y     C +C C  ++   +    C  ES
Sbjct: 397 CSIKSSELEPECDQCKDGYIGPNCNKCENGYYNFDSICRKCQCHGHVDPVKTPKICKPES 456

Query: 449 GRCL-CLPNVVGPKCDQC 465
           G C+ CL N  G  C+ C
Sbjct: 457 GECINCLHNTTGFWCENC 474



 Score = 31.2 bits (69), Expect = 6.1
 Identities = 19/55 (34%), Positives = 21/55 (38%), Gaps = 20/55 (36%)

Query: 250 CFCHGHADR------CAPKPGASAGPSTAVQVHDVCV-CQHNTAGPNCERCAPFY 297
           C CHGH D       C P+ G              C+ C HNT G  CE C   Y
Sbjct: 437 CQCHGHVDPVKTPKICKPESGE-------------CINCLHNTTGFWCENCLEGY 478


>gi|24586659 scavenger receptor class F, member 2 isoform 1 [Homo
           sapiens]
          Length = 870

 Score =  112 bits (280), Expect = 2e-24
 Identities = 114/365 (31%), Positives = 136/365 (37%), Gaps = 88/365 (24%)

Query: 250 CFCHGHADRCAPKPGASAGPST--AVQVHDVCVCQHNTAGPNCE--RCAPFYNNRPWRPA 305
           C CH H  +C    G     +     +    C CQH T  P     RC P      W  A
Sbjct: 126 CSCHPHG-QCEDVTGQCTCHARRWGARCEHACQCQHGTCHPRSGACRCEP-----GWWGA 179

Query: 306 EGQDAHECQ---RCDCNGHSETCHFDPAVFAASQGAYGGVCDN---CRDHTEGKNCERCQ 359
           +   A  C    RCD    +  CH          G +G  C+N   C      +   RCQ
Sbjct: 180 QCASACYCSATSRCDPQTGACLCH---------AGWWGRSCNNQCACNSSPCEQQSGRCQ 230

Query: 360 LHYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERC-DLCKPGFT 418
               R R  GA     C   +C          C PV G C C+   +G+ C + C  GF 
Sbjct: 231 C---RERTFGARCDRYC---QCFR------GRCHPVDGTCACEPGYRGKYCREPCPAGFY 278

Query: 419 GLTYANPQGCHRCDCNILGSRRDMPCDEESGRCL-CLPNVVGPKCDQ-CAPYHWKLASGQ 476
           GL      GC R      G +   PC    GRCL C P   G KCDQ CA   +      
Sbjct: 279 GL------GCRRRCGQCKGQQ---PCTVAEGRCLTCEPGWNGTKCDQPCATGFYGEGCSH 329

Query: 477 GCEPCACDPHNSLSPQCNQFTGQCP-CREGFGGLMCSAAAIRQCPDRTYG-DVATGCRAC 534
            C PC  D H      CN  TG+C  C  G+ G  C      +C + TYG D A  C  C
Sbjct: 330 RCPPCR-DGH-----ACNHVTGKCTRCNAGWIGDRCET----KCSNGTYGEDCAFVCADC 379

Query: 535 DCDFRGTEGPG-CDKASGRCLCRPGLTGPRCD----------------QCQRGYCNRYPV 577
                   G G CD  SGRCLC PG+ GP C+                 C    C+  PV
Sbjct: 380 --------GSGHCDFQSGRCLCSPGVHGPHCNVTCPPGLHGADCAQACSCHEDTCD--PV 429

Query: 578 CVACH 582
             ACH
Sbjct: 430 TGACH 434



 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 79/289 (27%), Positives = 101/289 (34%), Gaps = 95/289 (32%)

Query: 302 WRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCE-RCQL 360
           WR    Q   EC    C G+S TC  +            G C  CR    G NC+ +C  
Sbjct: 68  WR----QQGDECGIAVCEGNS-TCSENEVCVRP------GEC-RCRHGYFGANCDTKCPR 115

Query: 361 HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL 420
            ++     G   +E C    C P G      C+ VTGQC C     G RC+         
Sbjct: 116 QFW-----GPDCKELC---SCHPHGQ-----CEDVTGQCTCHARRWGARCE--------- 153

Query: 421 TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP 480
                   H C C      +   C   SG C C P   G +C                  
Sbjct: 154 --------HACQC------QHGTCHPRSGACRCEPGWWGAQC---------------ASA 184

Query: 481 CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG 540
           C C    S + +C+  TG C C  G+ G  C+     QC             AC+     
Sbjct: 185 CYC----SATSRCDPQTGACLCHAGWWGRSCN----NQC-------------ACNSS--- 220

Query: 541 TEGPGCDKASGRCLCRPGLTGPRCD---QCQRGYCNRYPVCVACHPCFQ 586
                C++ SGRC CR    G RCD   QC RG C+      AC P ++
Sbjct: 221 ----PCEQQSGRCQCRERTFGARCDRYCQCFRGRCHPVDGTCACEPGYR 265



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 82/301 (27%), Positives = 109/301 (36%), Gaps = 73/301 (24%)

Query: 249 SCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCE-RCAPFYNNRPWRPAEG 307
           +C+C     RC P+ GA             C+C     G +C  +CA   N+ P     G
Sbjct: 184 ACYCSA-TSRCDPQTGA-------------CLCHAGWWGRSCNNQCA--CNSSPCEQQSG 227

Query: 308 QDAHECQ--------RCD--CNGHSETCHFDPAVFAASQGAYGGVC-DNCRDHTEGKNCE 356
           +    CQ        RCD  C      CH      A   G  G  C + C     G  C 
Sbjct: 228 R----CQCRERTFGARCDRYCQCFRGRCHPVDGTCACEPGYRGKYCREPCPAGFYGLGCR 283

Query: 357 RCQLHYFRNRRPGASIQETCISCE-------CDPDGAV---------------PGAPCDP 394
           R +    + ++P    +  C++CE       CD   A                 G  C+ 
Sbjct: 284 R-RCGQCKGQQPCTVAEGRCLTCEPGWNGTKCDQPCATGFYGEGCSHRCPPCRDGHACNH 342

Query: 395 VTGQCV-CKEHVQGERCDL-CKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCL 452
           VTG+C  C     G+RC+  C  G    TY         DC   GS     CD +SGRCL
Sbjct: 343 VTGKCTRCNAGWIGDRCETKCSNG----TYGEDCAFVCADC---GSGH---CDFQSGRCL 392

Query: 453 CLPNVVGPKCDQCAP---YHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGL 509
           C P V GP C+   P   +    A    C    CDP   ++  C+  T Q     G G L
Sbjct: 393 CSPGVHGPHCNVTCPPGLHGADCAQACSCHEDTCDP---VTGACHLETNQRKGVMGAGAL 449

Query: 510 M 510
           +
Sbjct: 450 L 450



 Score = 51.2 bits (121), Expect = 6e-06
 Identities = 41/142 (28%), Positives = 60/142 (42%), Gaps = 24/142 (16%)

Query: 449 GRCLC-LPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQ--CNQFTGQCPCREG 505
           GR +C  P    P C  CA +  +   G  C    C+ +++ S    C +  G+C CR G
Sbjct: 50  GRNVCRAPGSQVPTC--CAGWRQQ---GDECGIAVCEGNSTCSENEVCVR-PGECRCRHG 103

Query: 506 FGGLMCSAAAIRQCPDRTYGDVATGCR-ACDCDFRGTEGPGCDKASGRCLCRPGLTGPRC 564
           + G  C      +CP + +G     C+  C C   G     C+  +G+C C     G RC
Sbjct: 104 YFGANCDT----KCPRQFWG---PDCKELCSCHPHGQ----CEDVTGQCTCHARRWGARC 152

Query: 565 D---QCQRGYCNRYPVCVACHP 583
           +   QCQ G C+       C P
Sbjct: 153 EHACQCQHGTCHPRSGACRCEP 174


>gi|33598937 scavenger receptor class F, member 2 isoform 2 [Homo
           sapiens]
          Length = 865

 Score =  112 bits (280), Expect = 2e-24
 Identities = 114/365 (31%), Positives = 136/365 (37%), Gaps = 88/365 (24%)

Query: 250 CFCHGHADRCAPKPGASAGPST--AVQVHDVCVCQHNTAGPNCE--RCAPFYNNRPWRPA 305
           C CH H  +C    G     +     +    C CQH T  P     RC P      W  A
Sbjct: 126 CSCHPHG-QCEDVTGQCTCHARRWGARCEHACQCQHGTCHPRSGACRCEP-----GWWGA 179

Query: 306 EGQDAHECQ---RCDCNGHSETCHFDPAVFAASQGAYGGVCDN---CRDHTEGKNCERCQ 359
           +   A  C    RCD    +  CH          G +G  C+N   C      +   RCQ
Sbjct: 180 QCASACYCSATSRCDPQTGACLCH---------AGWWGRSCNNQCACNSSPCEQQSGRCQ 230

Query: 360 LHYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERC-DLCKPGFT 418
               R R  GA     C   +C          C PV G C C+   +G+ C + C  GF 
Sbjct: 231 C---RERTFGARCDRYC---QCFR------GRCHPVDGTCACEPGYRGKYCREPCPAGFY 278

Query: 419 GLTYANPQGCHRCDCNILGSRRDMPCDEESGRCL-CLPNVVGPKCDQ-CAPYHWKLASGQ 476
           GL      GC R      G +   PC    GRCL C P   G KCDQ CA   +      
Sbjct: 279 GL------GCRRRCGQCKGQQ---PCTVAEGRCLTCEPGWNGTKCDQPCATGFYGEGCSH 329

Query: 477 GCEPCACDPHNSLSPQCNQFTGQCP-CREGFGGLMCSAAAIRQCPDRTYG-DVATGCRAC 534
            C PC  D H      CN  TG+C  C  G+ G  C      +C + TYG D A  C  C
Sbjct: 330 RCPPCR-DGH-----ACNHVTGKCTRCNAGWIGDRCET----KCSNGTYGEDCAFVCADC 379

Query: 535 DCDFRGTEGPG-CDKASGRCLCRPGLTGPRCD----------------QCQRGYCNRYPV 577
                   G G CD  SGRCLC PG+ GP C+                 C    C+  PV
Sbjct: 380 --------GSGHCDFQSGRCLCSPGVHGPHCNVTCPPGLHGADCAQACSCHEDTCD--PV 429

Query: 578 CVACH 582
             ACH
Sbjct: 430 TGACH 434



 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 79/289 (27%), Positives = 101/289 (34%), Gaps = 95/289 (32%)

Query: 302 WRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCE-RCQL 360
           WR    Q   EC    C G+S TC  +            G C  CR    G NC+ +C  
Sbjct: 68  WR----QQGDECGIAVCEGNS-TCSENEVCVRP------GEC-RCRHGYFGANCDTKCPR 115

Query: 361 HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL 420
            ++     G   +E C    C P G      C+ VTGQC C     G RC+         
Sbjct: 116 QFW-----GPDCKELC---SCHPHGQ-----CEDVTGQCTCHARRWGARCE--------- 153

Query: 421 TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP 480
                   H C C      +   C   SG C C P   G +C                  
Sbjct: 154 --------HACQC------QHGTCHPRSGACRCEPGWWGAQC---------------ASA 184

Query: 481 CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG 540
           C C    S + +C+  TG C C  G+ G  C+     QC             AC+     
Sbjct: 185 CYC----SATSRCDPQTGACLCHAGWWGRSCN----NQC-------------ACNSS--- 220

Query: 541 TEGPGCDKASGRCLCRPGLTGPRCD---QCQRGYCNRYPVCVACHPCFQ 586
                C++ SGRC CR    G RCD   QC RG C+      AC P ++
Sbjct: 221 ----PCEQQSGRCQCRERTFGARCDRYCQCFRGRCHPVDGTCACEPGYR 265



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 82/301 (27%), Positives = 109/301 (36%), Gaps = 73/301 (24%)

Query: 249 SCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCE-RCAPFYNNRPWRPAEG 307
           +C+C     RC P+ GA             C+C     G +C  +CA   N+ P     G
Sbjct: 184 ACYCSA-TSRCDPQTGA-------------CLCHAGWWGRSCNNQCA--CNSSPCEQQSG 227

Query: 308 QDAHECQ--------RCD--CNGHSETCHFDPAVFAASQGAYGGVC-DNCRDHTEGKNCE 356
           +    CQ        RCD  C      CH      A   G  G  C + C     G  C 
Sbjct: 228 R----CQCRERTFGARCDRYCQCFRGRCHPVDGTCACEPGYRGKYCREPCPAGFYGLGCR 283

Query: 357 RCQLHYFRNRRPGASIQETCISCE-------CDPDGAV---------------PGAPCDP 394
           R +    + ++P    +  C++CE       CD   A                 G  C+ 
Sbjct: 284 R-RCGQCKGQQPCTVAEGRCLTCEPGWNGTKCDQPCATGFYGEGCSHRCPPCRDGHACNH 342

Query: 395 VTGQCV-CKEHVQGERCDL-CKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCL 452
           VTG+C  C     G+RC+  C  G    TY         DC   GS     CD +SGRCL
Sbjct: 343 VTGKCTRCNAGWIGDRCETKCSNG----TYGEDCAFVCADC---GSGH---CDFQSGRCL 392

Query: 453 CLPNVVGPKCDQCAP---YHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGL 509
           C P V GP C+   P   +    A    C    CDP   ++  C+  T Q     G G L
Sbjct: 393 CSPGVHGPHCNVTCPPGLHGADCAQACSCHEDTCDP---VTGACHLETNQRKGVMGAGAL 449

Query: 510 M 510
           +
Sbjct: 450 L 450



 Score = 51.2 bits (121), Expect = 6e-06
 Identities = 41/142 (28%), Positives = 60/142 (42%), Gaps = 24/142 (16%)

Query: 449 GRCLC-LPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQ--CNQFTGQCPCREG 505
           GR +C  P    P C  CA +  +   G  C    C+ +++ S    C +  G+C CR G
Sbjct: 50  GRNVCRAPGSQVPTC--CAGWRQQ---GDECGIAVCEGNSTCSENEVCVR-PGECRCRHG 103

Query: 506 FGGLMCSAAAIRQCPDRTYGDVATGCR-ACDCDFRGTEGPGCDKASGRCLCRPGLTGPRC 564
           + G  C      +CP + +G     C+  C C   G     C+  +G+C C     G RC
Sbjct: 104 YFGANCDT----KCPRQFWG---PDCKELCSCHPHGQ----CEDVTGQCTCHARRWGARC 152

Query: 565 D---QCQRGYCNRYPVCVACHP 583
           +   QCQ G C+       C P
Sbjct: 153 EHACQCQHGTCHPRSGACRCEP 174


>gi|122937343 platelet endothelial aggregation receptor 1 [Homo
           sapiens]
          Length = 1037

 Score =  109 bits (272), Expect = 2e-23
 Identities = 107/346 (30%), Positives = 128/346 (36%), Gaps = 90/346 (26%)

Query: 250 CFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNC-ERCAPFYNNRPWRPAEGQ 308
           C C G+   C PK G             VC C      PNC + C P Y    + PA   
Sbjct: 148 CSC-GNNSSCDPKSG-------------VCSCPSGLQPPNCLQPCTPGY----YGPA--- 186

Query: 309 DAHECQ-RCDCNGHSETCHFDPAVFAASQGAYGGVCD-NCRDHTEGKNCERCQLHYFRNR 366
               CQ RC C  H   C              G  CD +C   T G  C     H  +N 
Sbjct: 187 ----CQFRCQC--HGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCP--STHSCQN- 237

Query: 367 RPGASIQETCISCECDPD--GAVPGAPC---------------------DPVTGQCVCKE 403
             G   Q    SC C P   G +   PC                     D  TGQC C  
Sbjct: 238 --GGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAP 295

Query: 404 HVQGERC-DLCKPGFTGLTYANPQGC-HRCDCNILGSRRDMPCDEESGRCLCLPNVVGPK 461
              G+RC + C  G  G      Q C   CDC       D  C   +G CLC     G +
Sbjct: 296 GYTGDRCREECPVGRFG------QDCAETCDC-----APDARCFPANGACLCEHGFTGDR 344

Query: 462 C-DQCAPYHWKLASGQGCE-PCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQC 519
           C D+  P  +    G  C+ PC CD  +SLS  C+   G+C C  G+ GL C+ +    C
Sbjct: 345 CTDRLCPDGFY---GLSCQAPCTCDREHSLS--CHPMNGECSCLPGWAGLHCNES----C 395

Query: 520 PDRTYGDVATGCRA-CDCDFRGTEGPGCDKASGRCLCRPGLTGPRC 564
           P  T+G    GC+  C C      G  C   SG C C PG TGP C
Sbjct: 396 PQDTHGP---GCQEHCLC----LHGGVCQATSGLCQCAPGYTGPHC 434



 Score =  106 bits (265), Expect = 1e-22
 Identities = 105/368 (28%), Positives = 136/368 (36%), Gaps = 91/368 (24%)

Query: 256 ADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNC-ERCAPFYNNRPWRPAEGQDAHECQ 314
           A+ C   P A   P+        C+C+H   G  C +R  P          +G     CQ
Sbjct: 316 AETCDCAPDARCFPANGA-----CLCEHGFTGDRCTDRLCP----------DGFYGLSCQ 360

Query: 315 R-CDCNG-HSETCHFDPAVFAASQGAYGGVC-DNCRDHTEGKNC-ERCQ-LHYFRNRRPG 369
             C C+  HS +CH      +   G  G  C ++C   T G  C E C  LH       G
Sbjct: 361 APCTCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLH-------G 413

Query: 370 ASIQETCISCECDPDGAVP-----------------------GAPCDPVTGQCVCKEHVQ 406
              Q T   C+C P    P                          C P+ G+CVCKE  Q
Sbjct: 414 GVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQ 473

Query: 407 GERCDL-CKPGFTGLTYANPQGCHR-CDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQ 464
              C + C PG  G +      C+  C C       +  C  ++G C C P   G  C  
Sbjct: 474 RGNCSVPCPPGTWGFS------CNASCQC-----AHEAVCSPQTGACTCTPGWHGAHCQL 522

Query: 465 CAPYHWKLASGQGCEP-CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRT 523
             P   K   G+GC   C CD     S  C+   G+C C+ G+ G  C  +    CP+  
Sbjct: 523 PCP---KGQFGEGCASRCDCDH----SDGCDPVHGRCQCQAGWMGARCHLS----CPEGL 571

Query: 524 YGDVATGC-RACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQ-CQRG-YCNRYPVCVA 580
           +G     C   C C   GT    C   +G C+C PG  GP C + CQ G Y  R   C  
Sbjct: 572 WG---VNCSNTCTCKNGGT----CLPENGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKC 624

Query: 581 -----CHP 583
                CHP
Sbjct: 625 ANHSFCHP 632



 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 91/323 (28%), Positives = 115/323 (35%), Gaps = 88/323 (27%)

Query: 249 SCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQ 308
           SC C  H   C+P+ GA             C C     G +C+   P          +GQ
Sbjct: 493 SCQC-AHEAVCSPQTGA-------------CTCTPGWHGAHCQLPCP----------KGQ 528

Query: 309 DAHEC-QRCDCNGHSETCHFDPAVFAASQGAYGGVCD-NCRDHTEGKNCERCQLHYFRNR 366
               C  RCDC+ HS+ C           G  G  C  +C +   G NC           
Sbjct: 529 FGEGCASRCDCD-HSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSN--------- 578

Query: 367 RPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDL-CKPGFTGLTYANP 425
                      +C C   G      C P  G CVC    +G  C   C+PG  G      
Sbjct: 579 -----------TCTCKNGGT-----CLPENGNCVCAPGFRGPSCQRSCQPGRYG------ 616

Query: 426 QGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQ-CAPYHWKLASGQGC-EPCAC 483
           + C  C C          C   +G C CL    GP C Q C P HW    G+ C + C C
Sbjct: 617 KRCVPCKC-----ANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHW----GENCAQTCQC 667

Query: 484 DPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEG 543
               +  PQ     G C C  G+ G  C    +  CP  T+G  A   + C C      G
Sbjct: 668 HHGGTCHPQ----DGSCICPLGWTGHHC----LEGCPLGTFG--ANCSQPCQC------G 711

Query: 544 PG--CDKASGRCLCRPGLTGPRC 564
           PG  C   +G C+C PG +G  C
Sbjct: 712 PGEKCHPETGACVCPPGHSGAPC 734



 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 68/229 (29%), Positives = 90/229 (39%), Gaps = 48/229 (20%)

Query: 380 ECD-PDGAVPGAPCDPVTGQCVCKEHVQGERC-DLCKPGFTGLTYANPQGCHRCDCNILG 437
           +CD P      + CDP +G C C   +Q   C   C PG+ G     P    RC C+   
Sbjct: 143 QCDKPCSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYG-----PACQFRCQCH--- 194

Query: 438 SRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSL-------S 490
                PCD ++G C C     GP CD        ++  QG     C   +S        +
Sbjct: 195 ---GAPCDPQTGACFCPAERTGPSCD--------VSCSQGTSGFFCPSTHSCQNGGVFQT 243

Query: 491 PQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKAS 550
           PQ     G C C  G+ G +CS      CP+  +G        C  + R   G  CD+ +
Sbjct: 244 PQ-----GSCSCPPGWMGTICSLP----CPEGFHGP------NCSQECRCHNGGLCDRFT 288

Query: 551 GRCLCRPGLTGPRC-DQCQRGY----CNRYPVCVACHPCFQTYDADLRE 594
           G+C C PG TG RC ++C  G     C     C     CF    A L E
Sbjct: 289 GQCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCFPANGACLCE 337



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 45/158 (28%), Positives = 62/158 (39%), Gaps = 42/158 (26%)

Query: 429 HRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNS 488
           ++C C + G R D  C  E     C P + GP+CD               +PC+C  ++S
Sbjct: 118 NQCQC-VPGWRGD-DCSSE-----CAPGMWGPQCD---------------KPCSCGNNSS 155

Query: 489 LSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFR-GTEGPGCD 547
             P+    +G C C  G     C    ++ C    YG          C FR    G  CD
Sbjct: 156 CDPK----SGVCSCPSGLQPPNC----LQPCTPGYYGPA--------CQFRCQCHGAPCD 199

Query: 548 KASGRCLCRPGLTGPRCD-QCQRGYCNRYPVCVACHPC 584
             +G C C    TGP CD  C +G    +  C + H C
Sbjct: 200 PQTGACFCPAERTGPSCDVSCSQGTSGFF--CPSTHSC 235


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.133    0.415 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,415,211
Number of Sequences: 37866
Number of extensions: 2392600
Number of successful extensions: 13434
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 123
Number of HSP's successfully gapped in prelim test: 532
Number of HSP's that attempted gapping in prelim test: 8107
Number of HSP's gapped (non-prelim): 2714
length of query: 1172
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1059
effective length of database: 13,968,660
effective search space: 14792810940
effective search space used: 14792810940
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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