Guide to the Human Genome
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Search of human proteins with 60115723

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo
sapiens]
         (823 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo sap...  1620   0.0  
gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo sap...  1615   0.0  
gi|156104901 ankyrin repeat domain 20 family, member A1 [Homo sa...  1609   0.0  
gi|149363679 ankyrin repeat domain 20 family, member A4 [Homo sa...  1605   0.0  
gi|239757009 PREDICTED: ankyrin repeat domain 20 family, member ...  1423   0.0  
gi|239751523 PREDICTED: ankyrin repeat domain 20 family, member ...  1423   0.0  
gi|239756999 PREDICTED: ankyrin repeat domain 62 [Homo sapiens]       471   e-133
gi|239751514 PREDICTED: ankyrin repeat domain 62 isoform 4 [Homo...   471   e-133
gi|239746016 PREDICTED: ankyrin repeat domain 62 isoform 1 [Homo...   470   e-132
gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]      379   e-105
gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]      379   e-105
gi|239743705 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]      377   e-104
gi|239741279 PREDICTED: similar to FLJ00310 protein [Homo sapiens]    377   e-104
gi|239755047 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]      369   e-102
gi|239749578 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]      369   e-102
gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]      369   e-102
gi|154354990 ankyrin repeat domain 26 [Homo sapiens]                  327   3e-89
gi|115495445 ankyrin repeat domain 30A [Homo sapiens]                 283   4e-76
gi|222537750 ankyrin repeat domain 30B [Homo sapiens]                 273   4e-73
gi|149363642 coiled-coil domain containing 144A [Homo sapiens]        273   4e-73
gi|153791352 prostate, ovary, testis expressed protein on chromo...   270   3e-72
gi|134133226 protein expressed in prostate, ovary, testis, and p...   270   4e-72
gi|113413200 PREDICTED: similar to protein expressed in prostate...   266   4e-71
gi|88953571 PREDICTED: similar to protein expressed in prostate,...   265   1e-70
gi|239741769 PREDICTED: similar to protein expressed in prostate...   248   2e-65
gi|239741786 PREDICTED: kappa-actin [Homo sapiens]                    246   6e-65
gi|239753333 PREDICTED: actin, beta-like 3 [Homo sapiens]             246   8e-65
gi|239747898 PREDICTED: actin, beta-like 3 [Homo sapiens]             246   8e-65
gi|53828703 POTE ankyrin domain family, member A isoform 2 [Homo...   240   4e-63
gi|52856434 POTE ankyrin domain family, member G [Homo sapiens]       231   2e-60

>gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo
           sapiens]
          Length = 823

 Score = 1620 bits (4196), Expect = 0.0
 Identities = 823/823 (100%), Positives = 823/823 (100%)

Query: 1   MKLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDL 60
           MKLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDL
Sbjct: 1   MKLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDL 60

Query: 61  DALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILL 120
           DALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILL
Sbjct: 61  DALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILL 120

Query: 121 EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEK 180
           EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEK
Sbjct: 121 EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEK 180

Query: 181 MVEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAI 240
           MVEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAI
Sbjct: 181 MVEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAI 240

Query: 241 SHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQC 300
           SHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQC
Sbjct: 241 SHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQC 300

Query: 301 VPEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRA 360
           VPEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRA
Sbjct: 301 VPEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRA 360

Query: 361 EQALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK 420
           EQALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK
Sbjct: 361 EQALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK 420

Query: 421 IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLE 480
           IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLE
Sbjct: 421 IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLE 480

Query: 481 PTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKEN 540
           PTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKEN
Sbjct: 481 PTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKEN 540

Query: 541 KYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKK 600
           KYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKK
Sbjct: 541 KYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKK 600

Query: 601 RLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFL 660
           RLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFL
Sbjct: 601 RLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFL 660

Query: 661 TEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKV 720
           TEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKV
Sbjct: 661 TEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKV 720

Query: 721 NNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEE 780
           NNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEE
Sbjct: 721 NNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEE 780

Query: 781 KSKKLMNECDHLKESLFQYEREKTEGVVSIKEDKYFQTSRKKI 823
           KSKKLMNECDHLKESLFQYEREKTEGVVSIKEDKYFQTSRKKI
Sbjct: 781 KSKKLMNECDHLKESLFQYEREKTEGVVSIKEDKYFQTSRKKI 823


>gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo
           sapiens]
          Length = 823

 Score = 1615 bits (4181), Expect = 0.0
 Identities = 821/823 (99%), Positives = 821/823 (99%)

Query: 1   MKLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDL 60
           MKLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDL
Sbjct: 1   MKLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDL 60

Query: 61  DALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILL 120
           DALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILL
Sbjct: 61  DALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILL 120

Query: 121 EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEK 180
           EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEK
Sbjct: 121 EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEK 180

Query: 181 MVEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAI 240
           MVEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAI
Sbjct: 181 MVEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAI 240

Query: 241 SHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQC 300
           SHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQC
Sbjct: 241 SHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQC 300

Query: 301 VPEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRA 360
           VPEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRA
Sbjct: 301 VPEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRA 360

Query: 361 EQALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK 420
           EQALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK
Sbjct: 361 EQALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK 420

Query: 421 IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLE 480
           IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLE
Sbjct: 421 IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLE 480

Query: 481 PTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKEN 540
           PTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKEN
Sbjct: 481 PTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKEN 540

Query: 541 KYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKK 600
           KYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELN LKAENTRLNAELLKEKESKK
Sbjct: 541 KYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNYLKAENTRLNAELLKEKESKK 600

Query: 601 RLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFL 660
           RLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFL
Sbjct: 601 RLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFL 660

Query: 661 TEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKV 720
           TEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKV
Sbjct: 661 TEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKV 720

Query: 721 NNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEE 780
           NNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEE
Sbjct: 721 NNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEE 780

Query: 781 KSKKLMNECDHLKESLFQYEREKTEGVVSIKEDKYFQTSRKKI 823
           KSKKLMNECDHLKESLFQYEREKTEGVVSIKEDKYFQTSRK I
Sbjct: 781 KSKKLMNECDHLKESLFQYEREKTEGVVSIKEDKYFQTSRKTI 823


>gi|156104901 ankyrin repeat domain 20 family, member A1 [Homo
           sapiens]
          Length = 823

 Score = 1609 bits (4167), Expect = 0.0
 Identities = 818/823 (99%), Positives = 819/823 (99%)

Query: 1   MKLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDL 60
           MKLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDL
Sbjct: 1   MKLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDL 60

Query: 61  DALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILL 120
           DALDKQHRTALHLAC SGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILL
Sbjct: 61  DALDKQHRTALHLACTSGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILL 120

Query: 121 EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEK 180
           EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEK
Sbjct: 121 EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEK 180

Query: 181 MVEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAI 240
           MVEFLLK+KASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAI
Sbjct: 181 MVEFLLKKKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAI 240

Query: 241 SHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQC 300
           SHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQC
Sbjct: 241 SHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQC 300

Query: 301 VPEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRA 360
           VPEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRA
Sbjct: 301 VPEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRA 360

Query: 361 EQALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK 420
           EQALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK
Sbjct: 361 EQALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK 420

Query: 421 IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLE 480
           IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLE
Sbjct: 421 IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLE 480

Query: 481 PTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKEN 540
           PTVQSLEMKSKTARNTPN DFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKEN
Sbjct: 481 PTVQSLEMKSKTARNTPNWDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKEN 540

Query: 541 KYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKK 600
           KYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKK
Sbjct: 541 KYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKK 600

Query: 601 RLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFL 660
           RLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVK ENEFL
Sbjct: 601 RLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKAENEFL 660

Query: 661 TEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKV 720
           TEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKV
Sbjct: 661 TEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKV 720

Query: 721 NNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEE 780
           NNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEE
Sbjct: 721 NNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEE 780

Query: 781 KSKKLMNECDHLKESLFQYEREKTEGVVSIKEDKYFQTSRKKI 823
           KSKKLMNECDHLKESLFQYEREKTEGVVSIKEDKYFQTSRK I
Sbjct: 781 KSKKLMNECDHLKESLFQYEREKTEGVVSIKEDKYFQTSRKTI 823


>gi|149363679 ankyrin repeat domain 20 family, member A4 [Homo
           sapiens]
          Length = 823

 Score = 1605 bits (4156), Expect = 0.0
 Identities = 815/823 (99%), Positives = 820/823 (99%)

Query: 1   MKLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDL 60
           MKLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSG+L
Sbjct: 1   MKLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGEL 60

Query: 61  DALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILL 120
           DALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILL
Sbjct: 61  DALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILL 120

Query: 121 EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEK 180
           EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEK
Sbjct: 121 EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEK 180

Query: 181 MVEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAI 240
           MVEFLLK+KASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAI
Sbjct: 181 MVEFLLKKKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAI 240

Query: 241 SHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQC 300
           SHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQC
Sbjct: 241 SHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQC 300

Query: 301 VPEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRA 360
           VPEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRA
Sbjct: 301 VPEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRA 360

Query: 361 EQALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK 420
           EQALPVASEEEQ+RHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK
Sbjct: 361 EQALPVASEEEQQRHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK 420

Query: 421 IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLE 480
           IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLE
Sbjct: 421 IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLE 480

Query: 481 PTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKEN 540
           PTVQSLEMKSKTARNTPN DFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKEN
Sbjct: 481 PTVQSLEMKSKTARNTPNWDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKEN 540

Query: 541 KYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKK 600
           KYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKK
Sbjct: 541 KYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKK 600

Query: 601 RLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFL 660
           RLEADIESYQSRLAAAISKHSESVKTERNLKLALERT+DVSVQVEMSSAISKVKDENEFL
Sbjct: 601 RLEADIESYQSRLAAAISKHSESVKTERNLKLALERTQDVSVQVEMSSAISKVKDENEFL 660

Query: 661 TEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKV 720
           TEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQN+LSQTQQQTQEMKEMYQNAEAKV
Sbjct: 661 TEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNNLSQTQQQTQEMKEMYQNAEAKV 720

Query: 721 NNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEE 780
           NNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKD VLEE
Sbjct: 721 NNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDFVLEE 780

Query: 781 KSKKLMNECDHLKESLFQYEREKTEGVVSIKEDKYFQTSRKKI 823
           KSKKLMNECDHLKESLFQYEREKTE VVSIKEDKYFQTSRKKI
Sbjct: 781 KSKKLMNECDHLKESLFQYEREKTEVVVSIKEDKYFQTSRKKI 823


>gi|239757009 PREDICTED: ankyrin repeat domain 20 family, member A5
           [Homo sapiens]
          Length = 823

 Score = 1423 bits (3683), Expect = 0.0
 Identities = 728/823 (88%), Positives = 770/823 (93%)

Query: 1   MKLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDL 60
           MKLFGF SRRGQT  GSIDH+YTGSGYRIR SELQKIH+AAVKGDAAE+ERCLARRSGDL
Sbjct: 1   MKLFGFRSRRGQTVLGSIDHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDL 60

Query: 61  DALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILL 120
           DALDKQHRTALHLACASGHV+VVTLLVNRKCQID+ DKENRTPLIQAVHCQEEACAVILL
Sbjct: 61  DALDKQHRTALHLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILL 120

Query: 121 EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEK 180
           EHGANPNLKDIYGNTALHYAVYSESTSLAEKLL HG +IEALDKD+NTPLLFAIICKKEK
Sbjct: 121 EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEK 180

Query: 181 MVEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAI 240
           MVEFLLK KAS+HAVDRLR +ALMLAV+YDS GIVNILLKQ+I+VF QDMCGRDAEDYAI
Sbjct: 181 MVEFLLKNKASTHAVDRLRXTALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAI 240

Query: 241 SHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQC 300
           S  LTKIQQQILEHKK ILK +K DVGSSDESAVSIFHEL VDSL A DD+ L+VA KQC
Sbjct: 241 SCRLTKIQQQILEHKKMILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQC 300

Query: 301 VPEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRA 360
           VPEKVSEPL G SH KGNRIVNG+GEGPPAKHPSLKPSTE+EDPAVKGAVQ KNVQTLRA
Sbjct: 301 VPEKVSEPLRGPSHGKGNRIVNGKGEGPPAKHPSLKPSTEMEDPAVKGAVQXKNVQTLRA 360

Query: 361 EQALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK 420
           EQALPVASEEEQ+R ERSEKKQPQV EGNNT KSEKIQLSENIC ST SAAA RLTQQRK
Sbjct: 361 EQALPVASEEEQQRRERSEKKQPQVIEGNNTYKSEKIQLSENICHSTFSAAADRLTQQRK 420

Query: 421 IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLE 480
           IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNML+KKNREELERKEKQYKKEVEAKQLE
Sbjct: 421 IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLHKKNREELERKEKQYKKEVEAKQLE 480

Query: 481 PTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKEN 540
           PTVQSLEMK KTARNTPN+DFHNHEE+K LMDENCILK DIAILRQEICTMKNDNLEKEN
Sbjct: 481 PTVQSLEMKPKTARNTPNQDFHNHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKEN 540

Query: 541 KYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKK 600
           KYLKDIKI KETNAALEK IKLNEEMIT+TAF YQQELNDLKAENTRLN+ELLKEKESKK
Sbjct: 541 KYLKDIKIAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAENTRLNSELLKEKESKK 600

Query: 601 RLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFL 660
           +LEA+IESYQSRLAAAISKHSE+VKTERNLKLALERT+D+S QV+MSS IS+++D+N FL
Sbjct: 601 KLEAEIESYQSRLAAAISKHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFL 660

Query: 661 TEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKV 720
           TEQLS+ QIKFN LKDKFRKTRD+LRKKSLALETVQNDLSQTQQQ +EMKEMYQ+AEAKV
Sbjct: 661 TEQLSKMQIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKV 720

Query: 721 NNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEE 780
           + STGKWNCVEERIC LQREN WL QQL DVHQKEDHKEIV NIQRGFIES KKDL+LEE
Sbjct: 721 SKSTGKWNCVEERICQLQRENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEE 780

Query: 781 KSKKLMNECDHLKESLFQYEREKTEGVVSIKEDKYFQTSRKKI 823
           K+KKLMNE DHLKESLFQYER+K E VVSIKEDKYFQTSRKK+
Sbjct: 781 KNKKLMNEYDHLKESLFQYERQKAETVVSIKEDKYFQTSRKKV 823


>gi|239751523 PREDICTED: ankyrin repeat domain 20 family, member A5
           [Homo sapiens]
          Length = 823

 Score = 1423 bits (3683), Expect = 0.0
 Identities = 728/823 (88%), Positives = 770/823 (93%)

Query: 1   MKLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDL 60
           MKLFGF SRRGQT  GSIDH+YTGSGYRIR SELQKIH+AAVKGDAAE+ERCLARRSGDL
Sbjct: 1   MKLFGFRSRRGQTVLGSIDHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDL 60

Query: 61  DALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILL 120
           DALDKQHRTALHLACASGHV+VVTLLVNRKCQID+ DKENRTPLIQAVHCQEEACAVILL
Sbjct: 61  DALDKQHRTALHLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILL 120

Query: 121 EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEK 180
           EHGANPNLKDIYGNTALHYAVYSESTSLAEKLL HG +IEALDKD+NTPLLFAIICKKEK
Sbjct: 121 EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEK 180

Query: 181 MVEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAI 240
           MVEFLLK KAS+HAVDRLR +ALMLAV+YDS GIVNILLKQ+I+VF QDMCGRDAEDYAI
Sbjct: 181 MVEFLLKNKASTHAVDRLRXTALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAI 240

Query: 241 SHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQC 300
           S  LTKIQQQILEHKK ILK +K DVGSSDESAVSIFHEL VDSL A DD+ L+VA KQC
Sbjct: 241 SCRLTKIQQQILEHKKMILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQC 300

Query: 301 VPEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRA 360
           VPEKVSEPL G SH KGNRIVNG+GEGPPAKHPSLKPSTE+EDPAVKGAVQ KNVQTLRA
Sbjct: 301 VPEKVSEPLRGPSHGKGNRIVNGKGEGPPAKHPSLKPSTEMEDPAVKGAVQXKNVQTLRA 360

Query: 361 EQALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK 420
           EQALPVASEEEQ+R ERSEKKQPQV EGNNT KSEKIQLSENIC ST SAAA RLTQQRK
Sbjct: 361 EQALPVASEEEQQRRERSEKKQPQVIEGNNTYKSEKIQLSENICHSTFSAAADRLTQQRK 420

Query: 421 IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLE 480
           IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNML+KKNREELERKEKQYKKEVEAKQLE
Sbjct: 421 IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLHKKNREELERKEKQYKKEVEAKQLE 480

Query: 481 PTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKEN 540
           PTVQSLEMK KTARNTPN+DFHNHEE+K LMDENCILK DIAILRQEICTMKNDNLEKEN
Sbjct: 481 PTVQSLEMKPKTARNTPNQDFHNHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKEN 540

Query: 541 KYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKK 600
           KYLKDIKI KETNAALEK IKLNEEMIT+TAF YQQELNDLKAENTRLN+ELLKEKESKK
Sbjct: 541 KYLKDIKIAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAENTRLNSELLKEKESKK 600

Query: 601 RLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFL 660
           +LEA+IESYQSRLAAAISKHSE+VKTERNLKLALERT+D+S QV+MSS IS+++D+N FL
Sbjct: 601 KLEAEIESYQSRLAAAISKHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFL 660

Query: 661 TEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKV 720
           TEQLS+ QIKFN LKDKFRKTRD+LRKKSLALETVQNDLSQTQQQ +EMKEMYQ+AEAKV
Sbjct: 661 TEQLSKMQIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKV 720

Query: 721 NNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEE 780
           + STGKWNCVEERIC LQREN WL QQL DVHQKEDHKEIV NIQRGFIES KKDL+LEE
Sbjct: 721 SKSTGKWNCVEERICQLQRENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEE 780

Query: 781 KSKKLMNECDHLKESLFQYEREKTEGVVSIKEDKYFQTSRKKI 823
           K+KKLMNE DHLKESLFQYER+K E VVSIKEDKYFQTSRKK+
Sbjct: 781 KNKKLMNEYDHLKESLFQYERQKAETVVSIKEDKYFQTSRKKV 823


>gi|239756999 PREDICTED: ankyrin repeat domain 62 [Homo sapiens]
          Length = 917

 Score =  471 bits (1213), Expect = e-133
 Identities = 312/839 (37%), Positives = 472/839 (56%), Gaps = 68/839 (8%)

Query: 22  YTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASGHVQ 81
           ++  GYR+R  +L  IH+AA+ GD  +V   +  R  DL+  DK++RTAL LACA G   
Sbjct: 27  FSNPGYRVRQKDLGMIHKAAIAGDVNKVMESILLRLNDLNDRDKKNRTALLLACAHGRPG 86

Query: 82  VVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALHYAV 141
           VV  LV RKCQ+++ D ENRT LI+AV CQEE CA ILLEHGANPN++D+YGNTALHYA+
Sbjct: 87  VVADLVARKCQLNLTDSENRTALIKAVQCQEEVCASILLEHGANPNVRDMYGNTALHYAI 146

Query: 142 YSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKMVEFLLKRKASSHAVDRLRRS 201
            +E+ S+A KLL++GA IEA  +D +T LL A+  KKE+MV FLLK+K    A+D   R+
Sbjct: 147 DNENISMARKLLAYGADIEARSQDGHTSLLLAVNRKKEQMVSFLLKKKPDLTAIDNFGRT 206

Query: 202 ALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKILKK 261
           AL+LA    S  +V  LL+ NIDVF QD+ G  AEDYA++     I+  I E+K    K+
Sbjct: 207 ALILAARNGSTSVVYQLLQHNIDVFCQDISGWTAEDYAVASKFQAIRGMISEYKAN--KR 264

Query: 262 EKSDVGSSDESAVSIFHELRVDSLPA--SDDKDLNVATKQCVPEK--VSEPLPGSSHEKG 317
            KS   S+ E  + +  E   + L    S    +    K+C  +K  VS  +     +  
Sbjct: 265 RKSLQNSNSEQDLEMTSEGEQERLEGCESSQPQVEEKMKKCRNKKMEVSRNVHADDSDNY 324

Query: 318 N----RIVNGQGEGPPAKHPSL-KPSTEVEDPAVKGAVQRKNVQTL--------RAEQAL 364
           N     +++      P  H S  K + E +  A K + ++  V++             + 
Sbjct: 325 NDDVDELIHKIKNRKPDNHQSPGKENGEFDRLARKTSNEKSKVKSQIYFTDDLNDISGSS 384

Query: 365 PVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK---- 420
              SE+++  +   E     +K+     K + + LS++     ++AA GR  + +K    
Sbjct: 385 EKTSEDDELPYSDDENFMLLIKQSGMECK-DFVSLSKS---KNATAACGRSIEDQKCYCE 440

Query: 421 ---------------IGKTYPQQFPKKLKEEHD-----------RCTLKQENEEKTNVNM 454
                          + K   +    K + EH            R  L+Q+ EE+     
Sbjct: 441 RLKVKFQKMKNNISVLQKVLSETDKTKSQSEHQNLQGKKKLCNLRFILQQQEEERIKAEE 500

Query: 455 LYKKNREELERKEKQYKKEVEA-KQLEPTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDE 513
           LY+K+ EEL+  E+QY+ + E  KQ + T++SLE++ KT R+  N++FH HE  + L  E
Sbjct: 501 LYEKDIEELKIMEEQYRTQTEVKKQSKLTLKSLEVELKTVRSNSNQNFHTHERERDLWQE 560

Query: 514 NCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFR 573
           N +++ +IA LR EI T+K+ N E ENKY KDI+I+KE N  LEK +K NEE +T+T  R
Sbjct: 561 NHLMRDEIARLRLEIDTIKHQNQETENKYFKDIEIIKENNEDLEKTLKRNEETLTKTITR 620

Query: 574 YQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTERNLKLA 633
           Y +ELN L  ENT LN+EL KEK+S  RLE ++ESY+ RLAAA+  H +   ++R+L+LA
Sbjct: 621 YSKELNVLMDENTMLNSELQKEKQSMSRLETEMESYRCRLAAALCDHDQRQSSKRDLQLA 680

Query: 634 LERTRD--VSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKDKFRKTRDSLRKKSLA 691
            + T +    +Q + +S I       + L++QLS+ +   + L+ +    R++L++K+L 
Sbjct: 681 FQSTVNEWCHLQEDTNSHI-------QILSQQLSKAESTSSGLETELHYEREALKEKTLH 733

Query: 692 LETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQQLDDV 751
           +E +Q  LS+TQ++ ++++ MYQN +  +     K   VE+ +  LQ +N    QQ +D 
Sbjct: 734 IEHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQQSVEDGLFQLQSQNLLYQQQCNDA 793

Query: 752 HQKEDHKE-IVTNIQRGFIESGKKDLV----LEEKSKKLMNECDHLKESLFQYEREKTE 805
            +K D++E  + NIQ    ++ +K       LEE +K LM EC  LKE   QYE+EK E
Sbjct: 794 RKKADNQEKTIINIQVKCEDTVEKLQAECRKLEENNKGLMKECTLLKERQCQYEKEKEE 852


>gi|239751514 PREDICTED: ankyrin repeat domain 62 isoform 4 [Homo
           sapiens]
          Length = 917

 Score =  471 bits (1213), Expect = e-133
 Identities = 312/839 (37%), Positives = 472/839 (56%), Gaps = 68/839 (8%)

Query: 22  YTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASGHVQ 81
           ++  GYR+R  +L  IH+AA+ GD  +V   +  R  DL+  DK++RTAL LACA G   
Sbjct: 27  FSNPGYRVRQKDLGMIHKAAIAGDVNKVMESILLRLNDLNDRDKKNRTALLLACAHGRPG 86

Query: 82  VVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALHYAV 141
           VV  LV RKCQ+++ D ENRT LI+AV CQEE CA ILLEHGANPN++D+YGNTALHYA+
Sbjct: 87  VVADLVARKCQLNLTDSENRTALIKAVQCQEEVCASILLEHGANPNVRDMYGNTALHYAI 146

Query: 142 YSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKMVEFLLKRKASSHAVDRLRRS 201
            +E+ S+A KLL++GA IEA  +D +T LL A+  KKE+MV FLLK+K    A+D   R+
Sbjct: 147 DNENISMARKLLAYGADIEARSQDGHTSLLLAVNRKKEQMVSFLLKKKPDLTAIDNFGRT 206

Query: 202 ALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKILKK 261
           AL+LA    S  +V  LL+ NIDVF QD+ G  AEDYA++     I+  I E+K    K+
Sbjct: 207 ALILAARNGSTSVVYQLLQHNIDVFCQDISGWTAEDYAVASKFQAIRGMISEYKAN--KR 264

Query: 262 EKSDVGSSDESAVSIFHELRVDSLPA--SDDKDLNVATKQCVPEK--VSEPLPGSSHEKG 317
            KS   S+ E  + +  E   + L    S    +    K+C  +K  VS  +     +  
Sbjct: 265 RKSLQNSNSEQDLEMTSEGEQERLEGCESSQPQVEEKMKKCRNKKMEVSRNVHADDSDNY 324

Query: 318 N----RIVNGQGEGPPAKHPSL-KPSTEVEDPAVKGAVQRKNVQTL--------RAEQAL 364
           N     +++      P  H S  K + E +  A K + ++  V++             + 
Sbjct: 325 NDDVDELIHKIKNRKPDNHQSPGKENGEFDRLARKTSNEKSKVKSQIYFTDDLNDISGSS 384

Query: 365 PVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK---- 420
              SE+++  +   E     +K+     K + + LS++     ++AA GR  + +K    
Sbjct: 385 EKTSEDDELPYSDDENFMLLIKQSGMECK-DFVSLSKS---KNATAACGRSIEDQKCYCE 440

Query: 421 ---------------IGKTYPQQFPKKLKEEHD-----------RCTLKQENEEKTNVNM 454
                          + K   +    K + EH            R  L+Q+ EE+     
Sbjct: 441 RLKVKFQKMKNNISVLQKVLSETDKTKSQSEHQNLQGKKKLCNLRFILQQQEEERIKAEE 500

Query: 455 LYKKNREELERKEKQYKKEVEA-KQLEPTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDE 513
           LY+K+ EEL+  E+QY+ + E  KQ + T++SLE++ KT R+  N++FH HE  + L  E
Sbjct: 501 LYEKDIEELKIMEEQYRTQTEVKKQSKLTLKSLEVELKTVRSNSNQNFHTHERERDLWQE 560

Query: 514 NCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFR 573
           N +++ +IA LR EI T+K+ N E ENKY KDI+I+KE N  LEK +K NEE +T+T  R
Sbjct: 561 NHLMRDEIARLRLEIDTIKHQNQETENKYFKDIEIIKENNEDLEKTLKRNEETLTKTITR 620

Query: 574 YQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTERNLKLA 633
           Y +ELN L  ENT LN+EL KEK+S  RLE ++ESY+ RLAAA+  H +   ++R+L+LA
Sbjct: 621 YSKELNVLMDENTMLNSELQKEKQSMSRLETEMESYRCRLAAALCDHDQRQSSKRDLQLA 680

Query: 634 LERTRD--VSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKDKFRKTRDSLRKKSLA 691
            + T +    +Q + +S I       + L++QLS+ +   + L+ +    R++L++K+L 
Sbjct: 681 FQSTVNEWCHLQEDTNSHI-------QILSQQLSKAESTSSGLETELHYEREALKEKTLH 733

Query: 692 LETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQQLDDV 751
           +E +Q  LS+TQ++ ++++ MYQN +  +     K   VE+ +  LQ +N    QQ +D 
Sbjct: 734 IEHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQQSVEDGLFQLQSQNLLYQQQCNDA 793

Query: 752 HQKEDHKE-IVTNIQRGFIESGKKDLV----LEEKSKKLMNECDHLKESLFQYEREKTE 805
            +K D++E  + NIQ    ++ +K       LEE +K LM EC  LKE   QYE+EK E
Sbjct: 794 RKKADNQEKTIINIQVKCEDTVEKLQAECRKLEENNKGLMKECTLLKERQCQYEKEKEE 852


>gi|239746016 PREDICTED: ankyrin repeat domain 62 isoform 1 [Homo
           sapiens]
          Length = 917

 Score =  470 bits (1209), Expect = e-132
 Identities = 311/838 (37%), Positives = 470/838 (56%), Gaps = 66/838 (7%)

Query: 22  YTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASGHVQ 81
           ++  GYR+R  +L  IH+AA+ GD  +V   +  R  DL+  DK++RTAL LACA G   
Sbjct: 27  FSNPGYRVRQKDLGMIHKAAIAGDVNKVMESILLRLNDLNDRDKKNRTALLLACAHGRPG 86

Query: 82  VVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALHYAV 141
           VV  LV RKCQ+++ D ENRT LI+AV CQEE CA ILLEHGANPN++D+YGNTALHYA+
Sbjct: 87  VVADLVARKCQLNLTDSENRTALIKAVQCQEEVCASILLEHGANPNVRDMYGNTALHYAI 146

Query: 142 YSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKMVEFLLKRKASSHAVDRLRRS 201
            +E+ S+A KLL++GA IEA  +D +T LL A+  KKE+MV FLLK+K    A+D   R+
Sbjct: 147 DNENISMARKLLAYGADIEARSQDGHTSLLLAVNRKKEQMVAFLLKKKPDLTAIDNFGRT 206

Query: 202 ALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKILKK 261
           AL+LA    S  +V  LL+ NIDVF QD+ G  AEDYA++     I+  I E+K    K+
Sbjct: 207 ALILAARNGSTSVVYQLLQHNIDVFCQDISGWTAEDYAVASKFQAIRGMISEYKAN--KR 264

Query: 262 EKSDVGSSDESAVSIFHELRVDSLPA--SDDKDLNVATKQCVPEK--VSEPLPGSSHEKG 317
            KS   S+ E  + +  E   + L    S    +    K+C  +K  VS  +     +  
Sbjct: 265 CKSLQNSNSEQDLEMTSEGEQERLEGCESSQPQVEEKMKKCRNKKMEVSRNVHADDSDNY 324

Query: 318 N----RIVNGQGEGPPAKHPSL-KPSTEVEDPAVKGAVQRKNVQT-------LRAEQALP 365
           N     +++      P  H S  K + E +  A K + ++  V++       L       
Sbjct: 325 NDDVDELIHKIKNRKPDNHQSPGKENGEFDRLARKTSNEKSKVKSQIYFTDDLNDISGSS 384

Query: 366 VASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK----- 420
             + E+ E     ++    + E +     + + LS++     ++AA GR  + +K     
Sbjct: 385 EKTSEDDELPYSDDENFMLLIEQSGMECKDFVSLSKS---KNATAACGRSIEDQKCYCER 441

Query: 421 --------------IGKTYPQQFPKKLKEEHD-----------RCTLKQENEEKTNVNML 455
                         + K   +    K + EH            R  L+Q+ EE+     L
Sbjct: 442 LKVKFQKMKNNISVLQKVLSETDKTKSQSEHQNLQGKKKLCNLRFILQQQEEERIKAEEL 501

Query: 456 YKKNREELERKEKQYKKEVEA-KQLEPTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDEN 514
           Y+K+ EEL+  E+QY+ + E  KQ + T++SLE++ KT R+  N++FH HE  + L  EN
Sbjct: 502 YEKDIEELKIMEEQYRTQTEVKKQSKLTLKSLEVELKTVRSNSNQNFHTHERERDLWQEN 561

Query: 515 CILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFRY 574
            +++ +IA LR EI T+K+ N E ENKY KDI+I+KE N  LEK +K NEE +T+T  RY
Sbjct: 562 HLMRDEIARLRLEIDTIKHQNQETENKYFKDIEIIKENNEDLEKTLKRNEEALTKTITRY 621

Query: 575 QQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTERNLKLAL 634
            +ELN L  ENT LN+EL KEK+S  RLE ++ESY+ RLAAA+  H +   ++R+L+LA 
Sbjct: 622 SKELNVLMDENTMLNSELQKEKQSMSRLETEMESYRCRLAAALCDHDQRQSSKRDLQLAF 681

Query: 635 ERTRD--VSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKDKFRKTRDSLRKKSLAL 692
           + T +    +Q + +S I       + L++QLS+ +   + L+ +    R++L++K+L +
Sbjct: 682 QSTVNEWCHLQEDTNSHI-------QILSQQLSKAESTSSGLETELHYEREALKEKTLHI 734

Query: 693 ETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQQLDDVH 752
           E +Q  LS+TQ++ ++++ MYQN +  +     K   VE+ +  LQ +N    QQ +D  
Sbjct: 735 EHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQQSVEDGLFQLQSQNLLYQQQCNDAR 794

Query: 753 QKEDHKE-IVTNIQRGFIESGKKDLV----LEEKSKKLMNECDHLKESLFQYEREKTE 805
           +K D++E  + NIQ    ++ +K       LEE +K LM EC  LKE   QYE+EK E
Sbjct: 795 KKADNQEKTIINIQVKCEDTVEKLQAECRKLEENNKGLMKECTLLKERQCQYEKEKEE 852


>gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
          Length = 1363

 Score =  379 bits (972), Expect = e-105
 Identities = 270/791 (34%), Positives = 392/791 (49%), Gaps = 142/791 (17%)

Query: 2   KLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLD 61
           KL  FG R GQ    S+D  Y G GY IRD EL+KIHRAA+KGDAAEVE CL RR  DLD
Sbjct: 102 KLLSFGRRLGQALLSSMDQEYAGRGYHIRDWELRKIHRAAIKGDAAEVEHCLTRRFRDLD 161

Query: 62  ALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLE 121
             DK+ RT LHLACA G VQVVTLL++RKCQI++CD+ NRTPL++AVHCQEEACA+ILL+
Sbjct: 162 VRDKKDRTVLHLACAHGRVQVVTLLLDRKCQINICDRLNRTPLMKAVHCQEEACAIILLK 221

Query: 122 HGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKM 181
            GANPN+KDIYGNTALHYAVY+E TSLAE+LLSH A+IEAL+K+ NTPLLFAI  +++ M
Sbjct: 222 RGANPNIKDIYGNTALHYAVYNEGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHM 281

Query: 182 VEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAIS 241
           VEFLLK +A+ HAVD  +R+AL+LAV ++   IV +LL+QNI + +QDM G+ AEDYA  
Sbjct: 282 VEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIHISSQDMFGQTAEDYAFC 341

Query: 242 HHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCV 301
             L  IQQQILEHK K+LK                 + LR D          N  T    
Sbjct: 342 CDLRSIQQQILEHKNKMLK-----------------NHLRND----------NQETAAMK 374

Query: 302 PEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAE 361
           PE + +        K  + +  + EG  A+H                             
Sbjct: 375 PENLKK-------RKKRKKLKKRKEGAKAEH----------------------------- 398

Query: 362 QALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKI 421
             L VASEE+QER ERSE KQPQ  +     K E                 G    +R I
Sbjct: 399 -NLKVASEEKQERLERSENKQPQDSQSYGKKKDEMF---------------GNFMLKRDI 442

Query: 422 GKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKK----NREELERKEKQYKKEVEAK 477
                + +  K           QE +  T +N  ++K    N E + +K  QY +++   
Sbjct: 443 AMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVAQYSQQLN-- 500

Query: 478 QLEPTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLE 537
                    ++K++ AR     +   H + +        L+A++  L   + T  N+  E
Sbjct: 501 ---------DLKAENARLNSKLEKEKHNKER--------LEAEVESLHSNLATAINEYNE 543

Query: 538 KENKYLKDIKIV---------KETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRL 588
              +  KD+++V          ET  +    +    E++TE   + + + N LK +    
Sbjct: 544 ILER--KDLELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRET 601

Query: 589 NAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRDVSVQVEMSS 648
              L ++  + + ++ D++  Q R+      H      E         ++ +  Q     
Sbjct: 602 RDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKE---------SQSIGKQNSSEE 652

Query: 649 AISKVKDENEFLTEQLSET-------QIKFNALKDKFRKTRDSL---RKKSLALE--TVQ 696
            I + + EN  L  QL +        +I  N  +D     ++ L   R K L  E   ++
Sbjct: 653 RIRQRELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMNEYNYLK 712

Query: 697 NDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERI-----CHLQRENAWLVQQ---L 748
             L Q +++  E + + +  + ++ +   K++  E  +     CH+  +  W  ++    
Sbjct: 713 EKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSESPLEGTSHCHINLDETWTSKKKLFQ 772

Query: 749 DDVHQKEDHKE 759
            ++  +E H+E
Sbjct: 773 VEIQPEEKHEE 783



 Score =  308 bits (789), Expect = 1e-83
 Identities = 170/374 (45%), Positives = 258/374 (68%), Gaps = 8/374 (2%)

Query: 442 LKQENEEKTNV---NMLYKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPN 498
           L+ +N+E   +   N+  +K R++L+++++  K E     L+   +  + + + + N   
Sbjct: 363 LRNDNQETAAMKPENLKKRKKRKKLKKRKEGAKAE---HNLKVASEEKQERLERSENKQP 419

Query: 499 RDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEK 558
           +D  ++ + K  M  N +LK DIA+L++E+  +KND+L KE KY+++IK + E NA  EK
Sbjct: 420 QDSQSYGKKKDEMFGNFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEK 479

Query: 559 YIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAIS 618
            ++LNEEMIT+   +Y Q+LNDLKAEN RLN++L KEK +K+RLEA++ES  S LA AI+
Sbjct: 480 SVRLNEEMITKKVAQYSQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHSNLATAIN 539

Query: 619 KHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKDKF 678
           +++E ++  ++L+L L R  DVS    M S IS++ D+NE LTEQ+ + ++KFN LK K 
Sbjct: 540 EYNEILE-RKDLELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKL 598

Query: 679 RKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQ 738
           R+TRD+LR+K+LALE+VQ DL Q Q + +EMK+M+ N EAK + S GK N  EERI   +
Sbjct: 599 RETRDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKESQSIGKQNSSEERIRQRE 658

Query: 739 RENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKESLFQ 798
            EN  L +QL+D  ++ D+KEIV NI R  +E+GK+DL LEE++K+LMNE ++LKE L Q
Sbjct: 659 LENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDL-LEERNKELMNEYNYLKEKLLQ 717

Query: 799 YEREKTEGVVSIKE 812
           YE+EK E  V ++E
Sbjct: 718 YEKEKAEREVIVRE 731


>gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
          Length = 1366

 Score =  379 bits (972), Expect = e-105
 Identities = 270/791 (34%), Positives = 392/791 (49%), Gaps = 142/791 (17%)

Query: 2   KLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLD 61
           KL  FG R GQ    S+D  Y G GY IRD EL+KIHRAA+KGDAAEVE CL RR  DLD
Sbjct: 131 KLLSFGRRLGQALLSSMDQEYAGRGYHIRDWELRKIHRAAIKGDAAEVEHCLTRRFRDLD 190

Query: 62  ALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLE 121
             DK+ RT LHLACA G VQVVTLL++RKCQI++CD+ NRTPL++AVHCQEEACA+ILL+
Sbjct: 191 VRDKKDRTVLHLACAHGRVQVVTLLLDRKCQINICDRLNRTPLMKAVHCQEEACAIILLK 250

Query: 122 HGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKM 181
            GANPN+KDIYGNTALHYAVY+E TSLAE+LLSH A+IEAL+K+ NTPLLFAI  +++ M
Sbjct: 251 RGANPNIKDIYGNTALHYAVYNEGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHM 310

Query: 182 VEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAIS 241
           VEFLLK +A+ HAVD  +R+AL+LAV ++   IV +LL+QNI + +QDM G+ AEDYA  
Sbjct: 311 VEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIHISSQDMFGQTAEDYAFC 370

Query: 242 HHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCV 301
             L  IQQQILEHK K+LK                 + LR D          N  T    
Sbjct: 371 CDLRSIQQQILEHKNKMLK-----------------NHLRND----------NQETAAMK 403

Query: 302 PEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAE 361
           PE + +        K  + +  + EG  A+H                             
Sbjct: 404 PENLKK-------RKKRKKLKKRKEGAKAEH----------------------------- 427

Query: 362 QALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKI 421
             L VASEE+QER ERSE KQPQ  +     K E                 G    +R I
Sbjct: 428 -NLKVASEEKQERLERSENKQPQDSQSYGKKKDEMF---------------GNFMLKRDI 471

Query: 422 GKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKK----NREELERKEKQYKKEVEAK 477
                + +  K           QE +  T +N  ++K    N E + +K  QY +++   
Sbjct: 472 AMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVAQYSQQLN-- 529

Query: 478 QLEPTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLE 537
                    ++K++ AR     +   H + +        L+A++  L   + T  N+  E
Sbjct: 530 ---------DLKAENARLNSKLEKEKHNKER--------LEAEVESLHSNLATAINEYNE 572

Query: 538 KENKYLKDIKIV---------KETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRL 588
              +  KD+++V          ET  +    +    E++TE   + + + N LK +    
Sbjct: 573 ILER--KDLELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRET 630

Query: 589 NAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRDVSVQVEMSS 648
              L ++  + + ++ D++  Q R+      H      E         ++ +  Q     
Sbjct: 631 RDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKE---------SQSIGKQNSSEE 681

Query: 649 AISKVKDENEFLTEQLSET-------QIKFNALKDKFRKTRDSL---RKKSLALE--TVQ 696
            I + + EN  L  QL +        +I  N  +D     ++ L   R K L  E   ++
Sbjct: 682 RIRQRELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMNEYNYLK 741

Query: 697 NDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERI-----CHLQRENAWLVQQ---L 748
             L Q +++  E + + +  + ++ +   K++  E  +     CH+  +  W  ++    
Sbjct: 742 EKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSESPLEGTSHCHINLDETWTSKKKLFQ 801

Query: 749 DDVHQKEDHKE 759
            ++  +E H+E
Sbjct: 802 VEIQPEEKHEE 812



 Score =  308 bits (789), Expect = 1e-83
 Identities = 170/374 (45%), Positives = 258/374 (68%), Gaps = 8/374 (2%)

Query: 442 LKQENEEKTNV---NMLYKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPN 498
           L+ +N+E   +   N+  +K R++L+++++  K E     L+   +  + + + + N   
Sbjct: 392 LRNDNQETAAMKPENLKKRKKRKKLKKRKEGAKAE---HNLKVASEEKQERLERSENKQP 448

Query: 499 RDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEK 558
           +D  ++ + K  M  N +LK DIA+L++E+  +KND+L KE KY+++IK + E NA  EK
Sbjct: 449 QDSQSYGKKKDEMFGNFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEK 508

Query: 559 YIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAIS 618
            ++LNEEMIT+   +Y Q+LNDLKAEN RLN++L KEK +K+RLEA++ES  S LA AI+
Sbjct: 509 SVRLNEEMITKKVAQYSQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHSNLATAIN 568

Query: 619 KHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKDKF 678
           +++E ++  ++L+L L R  DVS    M S IS++ D+NE LTEQ+ + ++KFN LK K 
Sbjct: 569 EYNEILE-RKDLELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKL 627

Query: 679 RKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQ 738
           R+TRD+LR+K+LALE+VQ DL Q Q + +EMK+M+ N EAK + S GK N  EERI   +
Sbjct: 628 RETRDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKESQSIGKQNSSEERIRQRE 687

Query: 739 RENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKESLFQ 798
            EN  L +QL+D  ++ D+KEIV NI R  +E+GK+DL LEE++K+LMNE ++LKE L Q
Sbjct: 688 LENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDL-LEERNKELMNEYNYLKEKLLQ 746

Query: 799 YEREKTEGVVSIKE 812
           YE+EK E  V ++E
Sbjct: 747 YEKEKAEREVIVRE 760


>gi|239743705 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
          Length = 1139

 Score =  377 bits (969), Expect = e-104
 Identities = 269/791 (34%), Positives = 392/791 (49%), Gaps = 142/791 (17%)

Query: 2   KLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLD 61
           KL  FG R GQ    S+D  Y G GY IRD EL+KIHRAA+KGDAAEVE CL RR  DLD
Sbjct: 131 KLLSFGRRLGQALLSSMDQEYAGRGYHIRDWELRKIHRAAIKGDAAEVEHCLTRRFRDLD 190

Query: 62  ALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLE 121
             D++ RT LHLACA G VQVVTLL++RKCQI++CD+ NRTPL++AVHCQEEACA+ILL+
Sbjct: 191 VRDRKDRTVLHLACAHGRVQVVTLLLDRKCQINICDRLNRTPLMKAVHCQEEACAIILLK 250

Query: 122 HGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKM 181
            GANPN+KDIYGNTALHYAVY+E TSLAE+LLSH A+IEAL+K+ NTPLLFAI  +++ M
Sbjct: 251 RGANPNIKDIYGNTALHYAVYNEGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHM 310

Query: 182 VEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAIS 241
           VEFLLK +A+ HAVD  +R+AL+LAV ++   IV +LL+QNI + +QDM G+ AEDYA  
Sbjct: 311 VEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIHISSQDMFGQTAEDYAFC 370

Query: 242 HHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCV 301
             L  IQQQILEHK K+LK                 + LR D          N  T    
Sbjct: 371 CDLRSIQQQILEHKNKMLK-----------------NHLRND----------NQETAAMK 403

Query: 302 PEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAE 361
           PE + +        K  + +  + EG  A+H                             
Sbjct: 404 PENLKK-------RKKRKKLKKRKEGAKAEH----------------------------- 427

Query: 362 QALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKI 421
             L VASEE+QER ERSE KQPQ  +     K E                 G    +R I
Sbjct: 428 -NLKVASEEKQERLERSENKQPQDSQSYGKKKDEMF---------------GNFMLKRDI 471

Query: 422 GKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKK----NREELERKEKQYKKEVEAK 477
                + +  K           QE +  T +N  ++K    N E + +K  QY +++   
Sbjct: 472 AMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVAQYSQQLN-- 529

Query: 478 QLEPTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLE 537
                    ++K++ AR     +   H + +        L+A++  L   + T  N+  E
Sbjct: 530 ---------DLKAENARLNSKLEKEKHNKER--------LEAEVESLHSNLATAINEYNE 572

Query: 538 KENKYLKDIKIV---------KETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRL 588
              +  KD+++V          ET  +    +    E++TE   + + + N LK +    
Sbjct: 573 ILER--KDLELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRET 630

Query: 589 NAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRDVSVQVEMSS 648
              L ++  + + ++ D++  Q R+      H      E         ++ +  Q     
Sbjct: 631 RDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKE---------SQSIGKQNSSEE 681

Query: 649 AISKVKDENEFLTEQLSET-------QIKFNALKDKFRKTRDSL---RKKSLALE--TVQ 696
            I + + EN  L  QL +        +I  N  +D     ++ L   R K L  E   ++
Sbjct: 682 RIRQRELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMNEYNYLK 741

Query: 697 NDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERI-----CHLQRENAWLVQQ---L 748
             L Q +++  E + + +  + ++ +   K++  E  +     CH+  +  W  ++    
Sbjct: 742 EKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSESPLEGTSHCHINLDETWTSKKKLFQ 801

Query: 749 DDVHQKEDHKE 759
            ++  +E H+E
Sbjct: 802 VEIQPEEKHEE 812



 Score =  308 bits (789), Expect = 1e-83
 Identities = 170/374 (45%), Positives = 258/374 (68%), Gaps = 8/374 (2%)

Query: 442 LKQENEEKTNV---NMLYKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPN 498
           L+ +N+E   +   N+  +K R++L+++++  K E     L+   +  + + + + N   
Sbjct: 392 LRNDNQETAAMKPENLKKRKKRKKLKKRKEGAKAE---HNLKVASEEKQERLERSENKQP 448

Query: 499 RDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEK 558
           +D  ++ + K  M  N +LK DIA+L++E+  +KND+L KE KY+++IK + E NA  EK
Sbjct: 449 QDSQSYGKKKDEMFGNFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEK 508

Query: 559 YIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAIS 618
            ++LNEEMIT+   +Y Q+LNDLKAEN RLN++L KEK +K+RLEA++ES  S LA AI+
Sbjct: 509 SVRLNEEMITKKVAQYSQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHSNLATAIN 568

Query: 619 KHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKDKF 678
           +++E ++  ++L+L L R  DVS    M S IS++ D+NE LTEQ+ + ++KFN LK K 
Sbjct: 569 EYNEILE-RKDLELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKL 627

Query: 679 RKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQ 738
           R+TRD+LR+K+LALE+VQ DL Q Q + +EMK+M+ N EAK + S GK N  EERI   +
Sbjct: 628 RETRDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKESQSIGKQNSSEERIRQRE 687

Query: 739 RENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKESLFQ 798
            EN  L +QL+D  ++ D+KEIV NI R  +E+GK+DL LEE++K+LMNE ++LKE L Q
Sbjct: 688 LENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDL-LEERNKELMNEYNYLKEKLLQ 746

Query: 799 YEREKTEGVVSIKE 812
           YE+EK E  V ++E
Sbjct: 747 YEKEKAEREVIVRE 760


>gi|239741279 PREDICTED: similar to FLJ00310 protein [Homo sapiens]
          Length = 561

 Score =  377 bits (967), Expect = e-104
 Identities = 239/529 (45%), Positives = 323/529 (61%), Gaps = 46/529 (8%)

Query: 265 DVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCVPEKVSEPLPGSSHEKGNRIVNGQ 324
           DVG SDESAVSI HEL VDSLP  DD+DL+VATKQCVPEKVSEPL G SHEKGNRIVNG+
Sbjct: 54  DVGISDESAVSILHELCVDSLPTLDDEDLSVATKQCVPEKVSEPLRGPSHEKGNRIVNGK 113

Query: 325 GEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQ 384
           G+GPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQ LPVA EEEQER ERSEKKQ Q
Sbjct: 114 GKGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQTLPVALEEEQERCERSEKKQSQ 173

Query: 385 VKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQ 444
           VKEGNNTNKSEKIQLSEN+C STSSAAA RLT+QRK+GKTYPQQFPKKLK+EHD      
Sbjct: 174 VKEGNNTNKSEKIQLSENVCHSTSSAAADRLTKQRKVGKTYPQQFPKKLKKEHD------ 227

Query: 445 ENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPNR--DFH 502
                          REELERKEKQYKKEVEAKQLEPTVQSL+MK KT RNTPN+     
Sbjct: 228 ---------------REELERKEKQYKKEVEAKQLEPTVQSLDMKLKTTRNTPNQINQSL 272

Query: 503 NHEEMKGLMDENCILKADIAILRQEICTMKN--DNLE-KENKYLKDIKIVKETNAALEKY 559
            + + K +   N     D++  +Q+I  MK   +N E K N        V+E    L+  
Sbjct: 273 RYSQKKVIGFRNS--PNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHE 330

Query: 560 IKLNEEMITETAFR--YQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAI 617
               E+ + +   +  +++ + +++        + L  +E  K+L  + +  +  L    
Sbjct: 331 NPCIEQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNECDHLKESLFQYE 390

Query: 618 SKHSESVKTERNLKL----ALERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFN- 672
            + +E V   R L+     +L++   +   +E  S      DE +   ++L + + +F+ 
Sbjct: 391 REKAERVVVVRQLQQEAADSLKKLTMLESPLEGISHYHINLDETQVPKKKLFQVESQFDD 450

Query: 673 ------ALKDK---FRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNS 723
                 A+  K     K     +++ L+++ VQ +  + ++  + ++E   N +  + NS
Sbjct: 451 FMAEKEAVSSKCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKMLEEEILNLKTHMENS 510

Query: 724 TGKWNCVEERICHLQRENAWLVQQLDDVHQKE--DHKEIVTNIQRGFIE 770
             + + ++E    L       V++L+++H +E  +HK+ +  + +  I+
Sbjct: 511 MVELSKLQEYKSELDERAMQAVEKLEEIHLQEQAEHKKQLEQLNKDIIQ 559



 Score =  212 bits (540), Expect = 1e-54
 Identities = 129/263 (49%), Positives = 160/263 (60%), Gaps = 19/263 (7%)

Query: 562 LNEEMITETAFRYQQELNDLKAENTRLNAELLKE-----KESKKRLEADI-ESYQSRLAA 615
           L  E     A   +QE    + E +      +KE     K  K +L  ++  S  S  A 
Sbjct: 147 LRAEQTLPVALEEEQE----RCERSEKKQSQVKEGNNTNKSEKIQLSENVCHSTSSAAAD 202

Query: 616 AISKHSESVKT---ERNLKLALERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFN 672
            ++K  +  KT   +   KL  E  R+   ++E      K + E + L   +    +K  
Sbjct: 203 RLTKQRKVGKTYPQQFPKKLKKEHDRE---ELERKEKQYKKEVEAKQLEPTVQSLDMKLK 259

Query: 673 ALKDKFRKTRDSLR---KKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNC 729
             ++   +   SLR   KK +      NDLSQTQQQ +EMKEMY+NAEAKVNNSTGKW+C
Sbjct: 260 TTRNTPNQINQSLRYSQKKVIGFRNSPNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSC 319

Query: 730 VEERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEEKSKKLMNEC 789
           VEERIC LQ EN  + QQLDDVHQKEDHKEIVTNIQRGFIESGKKDL+LEEK+KKLMNEC
Sbjct: 320 VEERICQLQHENPCIEQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNEC 379

Query: 790 DHLKESLFQYEREKTEGVVSIKE 812
           DHLKESLFQYEREK E VV +++
Sbjct: 380 DHLKESLFQYEREKAERVVVVRQ 402


>gi|239755047 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
          Length = 1415

 Score =  369 bits (947), Expect = e-102
 Identities = 290/904 (32%), Positives = 437/904 (48%), Gaps = 120/904 (13%)

Query: 2   KLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLD 61
           KLF FG R GQ    S+D  Y G GY IRD EL+KIHRAA+KGDAAEVERCL RR  DLD
Sbjct: 110 KLFSFGRRLGQALLSSMDQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLD 169

Query: 62  ALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLE 121
           A D++ RT LHLACA G VQVVTLL++R+CQID+CD+ NRTPL++AVH QEEACA++LLE
Sbjct: 170 ARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLE 229

Query: 122 HGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKM 181
            GANPN++DIYGNTALHYAVY++ TSLAE+LLSH A+IEAL+K+ NTPLLFAI  +++ M
Sbjct: 230 CGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHM 289

Query: 182 VEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAIS 241
           VEFLLK +A+ HAVD  +R+AL+LAV ++   IV +LL+QNI + +QDM G+ AEDYA+ 
Sbjct: 290 VEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALC 349

Query: 242 HHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCV 301
             L  I+QQILEHK K+LK                 + LR D+   +  K  N+  K+  
Sbjct: 350 SDLRSIRQQILEHKNKMLK-----------------NHLRNDNQETAAMKPANL-KKRKE 391

Query: 302 PEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAE 361
             K    L  +S EK  R+   + + P       K     +D      + +K++  L+ E
Sbjct: 392 RAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKK----KDAMYGNFMLKKDIAMLKEE 447

Query: 362 -QALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK 420
             A+   S  +++++ +  K   ++    N N  + ++L+E +   T      R +QQ  
Sbjct: 448 LYAIKNDSLRKEKKYIQEIKSITEI----NANFEKSVRLNEKMITKT----VARYSQQLN 499

Query: 421 IGKTYPQQFPKKL-KEEHDRCTLKQENE-------------------------------- 447
             K    +   +L KE+H++  L+ E E                                
Sbjct: 500 DLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRADDV 559

Query: 448 ---EK--TNVNMLYKKNREELERKEKQYKKEVEAK-QLEPTVQSLEMKSKTARNTP---N 498
              EK  +N++ L  KN    E+  K   K    K +L  T  +L  K+    +      
Sbjct: 560 SRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLR 619

Query: 499 RDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYL-KDIKIVKETNAALE 557
           +  H  +EMK  M  N   K   +I +Q     +    E EN  L + ++  ++     E
Sbjct: 620 QAQHRIKEMK-QMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKE 678

Query: 558 KYIKLNEEMITETAFRYQQELN-DLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAA 616
             I ++ + +        +E N +L  E   L  +LL+ ++ K   E  +  +Q  L   
Sbjct: 679 IVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELV-- 736

Query: 617 ISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKD 676
                + +KT    +  LE T    + +  +    K   + E   E+  E   K   L  
Sbjct: 737 -----DHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELIS 791

Query: 677 KFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAE------------------- 717
               T D +RKK+  LE       +  + T  M   + N +                   
Sbjct: 792 LLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFK 851

Query: 718 ---AKVNNSTGKWNCVEERICHLQRENAWLVQQL---------------DDVHQKEDHKE 759
               K N+   +   V     +L ++N  L Q+L               D    +E+   
Sbjct: 852 KLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLN 911

Query: 760 IVTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKESLFQYEREKTEGVVSIKEDKYFQTS 819
           + T++++  +E GK      E  ++ + E + L+E   Q + E  + +  + +D      
Sbjct: 912 LKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLK 971

Query: 820 RKKI 823
           +K++
Sbjct: 972 KKEL 975



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 49/238 (20%), Positives = 100/238 (42%), Gaps = 46/238 (19%)

Query: 431  KKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERK--------EKQYKKEVEAKQLEPT 482
            KKLK++ +    ++E      VN+   K+ E L ++        EK  K E + K LE  
Sbjct: 851  KKLKQKFNDLVAEKEAVSSECVNLA--KDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEE 908

Query: 483  VQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKY 542
            V +L    KT       +    +E K  +DE  +         QEI  ++  +L+K+ +Y
Sbjct: 909  VLNL----KTHMEKDMVELGKLQEYKSELDERAV---------QEIEKLEEIHLQKQAEY 955

Query: 543  LKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRL 602
             K ++ + + N A  K  +L               L D++ + +++       K + + +
Sbjct: 956  EKQLEQLNKDNTASLKKKELT--------------LKDVECKFSKM-------KTAYEEV 994

Query: 603  EADIESYQSRLAAAISKHSESVK--TERNLKLALERTRDVSVQVEMSSAISKVKDENE 658
              ++E ++   A A+  ++   K   + + K+A+  T+  + +  M   +S +    E
Sbjct: 995  TTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLPTRPE 1052


>gi|239749578 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
          Length = 1002

 Score =  369 bits (947), Expect = e-102
 Identities = 290/904 (32%), Positives = 437/904 (48%), Gaps = 120/904 (13%)

Query: 2   KLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLD 61
           KLF FG R GQ    S+D  Y G GY IRD EL+KIHRAA+KGDAAEVERCL RR  DLD
Sbjct: 3   KLFSFGRRLGQALLSSMDQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLD 62

Query: 62  ALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLE 121
           A D++ RT LHLACA G VQVVTLL++R+CQID+CD+ NRTPL++AVH QEEACA++LLE
Sbjct: 63  ARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLE 122

Query: 122 HGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKM 181
            GANPN++DIYGNTALHYAVY++ TSLAE+LLSH A+IEAL+K+ NTPLLFAI  +++ M
Sbjct: 123 CGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHM 182

Query: 182 VEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAIS 241
           VEFLLK +A+ HAVD  +R+AL+LAV ++   IV +LL+QNI + +QDM G+ AEDYA+ 
Sbjct: 183 VEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALC 242

Query: 242 HHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCV 301
             L  I+QQILEHK K+LK                 + LR D+   +  K  N+  K+  
Sbjct: 243 SDLRSIRQQILEHKNKMLK-----------------NHLRNDNQETAAMKPANL-KKRKE 284

Query: 302 PEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAE 361
             K    L  +S EK  R+   + + P       K     +D      + +K++  L+ E
Sbjct: 285 RAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKK----KDAMYGNFMLKKDIAMLKEE 340

Query: 362 -QALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK 420
             A+   S  +++++ +  K   ++    N N  + ++L+E +   T      R +QQ  
Sbjct: 341 LYAIKNDSLRKEKKYIQEIKSITEI----NANFEKSVRLNEKMITKT----VARYSQQLN 392

Query: 421 IGKTYPQQFPKKL-KEEHDRCTLKQENE-------------------------------- 447
             K    +   +L KE+H++  L+ E E                                
Sbjct: 393 DLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRADDV 452

Query: 448 ---EK--TNVNMLYKKNREELERKEKQYKKEVEAK-QLEPTVQSLEMKSKTARNTP---N 498
              EK  +N++ L  KN    E+  K   K    K +L  T  +L  K+    +      
Sbjct: 453 SRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLR 512

Query: 499 RDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYL-KDIKIVKETNAALE 557
           +  H  +EMK  M  N   K   +I +Q     +    E EN  L + ++  ++     E
Sbjct: 513 QAQHRIKEMK-QMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKE 571

Query: 558 KYIKLNEEMITETAFRYQQELN-DLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAA 616
             I ++ + +        +E N +L  E   L  +LL+ ++ K   E  +  +Q  L   
Sbjct: 572 IVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELV-- 629

Query: 617 ISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKD 676
                + +KT    +  LE T    + +  +    K   + E   E+  E   K   L  
Sbjct: 630 -----DHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELIS 684

Query: 677 KFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAE------------------- 717
               T D +RKK+  LE       +  + T  M   + N +                   
Sbjct: 685 LLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFK 744

Query: 718 ---AKVNNSTGKWNCVEERICHLQRENAWLVQQL---------------DDVHQKEDHKE 759
               K N+   +   V     +L ++N  L Q+L               D    +E+   
Sbjct: 745 KLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLN 804

Query: 760 IVTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKESLFQYEREKTEGVVSIKEDKYFQTS 819
           + T++++  +E GK      E  ++ + E + L+E   Q + E  + +  + +D      
Sbjct: 805 LKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLK 864

Query: 820 RKKI 823
           +K++
Sbjct: 865 KKEL 868



 Score = 32.3 bits (72), Expect = 1.8
 Identities = 43/203 (21%), Positives = 85/203 (41%), Gaps = 44/203 (21%)

Query: 431 KKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERK--------EKQYKKEVEAKQLEPT 482
           KKLK++ +    ++E      VN+   K+ E L ++        EK  K E + K LE  
Sbjct: 744 KKLKQKFNDLVAEKEAVSSECVNLA--KDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEE 801

Query: 483 VQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKY 542
           V +L    KT       +    +E K  +DE  +         QEI  ++  +L+K+ +Y
Sbjct: 802 VLNL----KTHMEKDMVELGKLQEYKSELDERAV---------QEIEKLEEIHLQKQAEY 848

Query: 543 LKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRL 602
            K ++ + + N A  K  +L               L D++ + +++       K + + +
Sbjct: 849 EKQLEQLNKDNTASLKKKELT--------------LKDVECKFSKM-------KTAYEEV 887

Query: 603 EADIESYQSRLAAAISKHSESVK 625
             ++E ++   A A+  ++   K
Sbjct: 888 TTELEEFKEAFAGAVKANNSMSK 910


>gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
          Length = 1415

 Score =  369 bits (947), Expect = e-102
 Identities = 290/904 (32%), Positives = 437/904 (48%), Gaps = 120/904 (13%)

Query: 2   KLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLD 61
           KLF FG R GQ    S+D  Y G GY IRD EL+KIHRAA+KGDAAEVERCL RR  DLD
Sbjct: 110 KLFSFGRRLGQALLSSMDQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLD 169

Query: 62  ALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLE 121
           A D++ RT LHLACA G VQVVTLL++R+CQID+CD+ NRTPL++AVH QEEACA++LLE
Sbjct: 170 ARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLE 229

Query: 122 HGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKM 181
            GANPN++DIYGNTALHYAVY++ TSLAE+LLSH A+IEAL+K+ NTPLLFAI  +++ M
Sbjct: 230 CGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHM 289

Query: 182 VEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAIS 241
           VEFLLK +A+ HAVD  +R+AL+LAV ++   IV +LL+QNI + +QDM G+ AEDYA+ 
Sbjct: 290 VEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALC 349

Query: 242 HHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCV 301
             L  I+QQILEHK K+LK                 + LR D+   +  K  N+  K+  
Sbjct: 350 SDLRSIRQQILEHKNKMLK-----------------NHLRNDNQETAAMKPANL-KKRKE 391

Query: 302 PEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAE 361
             K    L  +S EK  R+   + + P       K     +D      + +K++  L+ E
Sbjct: 392 RAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKK----KDAMYGNFMLKKDIAMLKEE 447

Query: 362 -QALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK 420
             A+   S  +++++ +  K   ++    N N  + ++L+E +   T      R +QQ  
Sbjct: 448 LYAIKNDSLRKEKKYIQEIKSITEI----NANFEKSVRLNEKMITKT----VARYSQQLN 499

Query: 421 IGKTYPQQFPKKL-KEEHDRCTLKQENE-------------------------------- 447
             K    +   +L KE+H++  L+ E E                                
Sbjct: 500 DLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRADDV 559

Query: 448 ---EK--TNVNMLYKKNREELERKEKQYKKEVEAK-QLEPTVQSLEMKSKTARNTP---N 498
              EK  +N++ L  KN    E+  K   K    K +L  T  +L  K+    +      
Sbjct: 560 SRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLR 619

Query: 499 RDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYL-KDIKIVKETNAALE 557
           +  H  +EMK  M  N   K   +I +Q     +    E EN  L + ++  ++     E
Sbjct: 620 QAQHRIKEMK-QMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKE 678

Query: 558 KYIKLNEEMITETAFRYQQELN-DLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAA 616
             I ++ + +        +E N +L  E   L  +LL+ ++ K   E  +  +Q  L   
Sbjct: 679 IVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELV-- 736

Query: 617 ISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKD 676
                + +KT    +  LE T    + +  +    K   + E   E+  E   K   L  
Sbjct: 737 -----DHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELIS 791

Query: 677 KFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAE------------------- 717
               T D +RKK+  LE       +  + T  M   + N +                   
Sbjct: 792 LLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFK 851

Query: 718 ---AKVNNSTGKWNCVEERICHLQRENAWLVQQL---------------DDVHQKEDHKE 759
               K N+   +   V     +L ++N  L Q+L               D    +E+   
Sbjct: 852 KLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLN 911

Query: 760 IVTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKESLFQYEREKTEGVVSIKEDKYFQTS 819
           + T++++  +E GK      E  ++ + E + L+E   Q + E  + +  + +D      
Sbjct: 912 LKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLK 971

Query: 820 RKKI 823
           +K++
Sbjct: 972 KKEL 975



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 49/238 (20%), Positives = 100/238 (42%), Gaps = 46/238 (19%)

Query: 431  KKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERK--------EKQYKKEVEAKQLEPT 482
            KKLK++ +    ++E      VN+   K+ E L ++        EK  K E + K LE  
Sbjct: 851  KKLKQKFNDLVAEKEAVSSECVNLA--KDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEE 908

Query: 483  VQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKY 542
            V +L    KT       +    +E K  +DE  +         QEI  ++  +L+K+ +Y
Sbjct: 909  VLNL----KTHMEKDMVELGKLQEYKSELDERAV---------QEIEKLEEIHLQKQAEY 955

Query: 543  LKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRL 602
             K ++ + + N A  K  +L               L D++ + +++       K + + +
Sbjct: 956  EKQLEQLNKDNTASLKKKELT--------------LKDVECKFSKM-------KTAYEEV 994

Query: 603  EADIESYQSRLAAAISKHSESVK--TERNLKLALERTRDVSVQVEMSSAISKVKDENE 658
              ++E ++   A A+  ++   K   + + K+A+  T+  + +  M   +S +    E
Sbjct: 995  TTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLPTRPE 1052


>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
          Length = 1710

 Score =  327 bits (838), Expect = 3e-89
 Identities = 195/444 (43%), Positives = 275/444 (61%), Gaps = 62/444 (13%)

Query: 431  KKLKEEHDRCTLK----QENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQ-LEPTVQS 485
            +K++ E + C+L+    QE E++ N + LY+K RE+L RKE+QY+KEVE KQ LE ++Q+
Sbjct: 780  QKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQT 839

Query: 486  LEMKSKTARNTPNR---------------------------------------------- 499
            LEM+ +T ++  N+                                              
Sbjct: 840  LEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSE 899

Query: 500  DFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEKY 559
            + H+HEE K L  +N +L+ +IA+LR EI T+KN N EKE K  +D+KIVKE N  L+K 
Sbjct: 900  NSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKT 959

Query: 560  IKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISK 619
            IK NEE +T+T  +Y   L+ L AEN  LN++L  EK+SK+RLEA++ESY SRLAAAI  
Sbjct: 960  IKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHD 1019

Query: 620  HSESVKTERNLKLALERTRD--VSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKDK 677
              +S  ++R L+LA +R RD    +Q +M+  +S +KD NE L++QL +T+ K N+L+ +
Sbjct: 1020 RDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIE 1079

Query: 678  FRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHL 737
            F  TRD+LR+K+L LE VQ DLSQTQ Q +EM++ YQN + KVN   GK   VEER+  L
Sbjct: 1080 FHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQL 1139

Query: 738  QRENAWLVQQLDDVHQKEDHKE-IVTNIQRGF--------IESGKKDLVLEEKSKKLMNE 788
            Q EN  L QQLDD H K D+KE  V NIQ  F         ES K+ L+LEE++K+L++E
Sbjct: 1140 QSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISE 1199

Query: 789  CDHLKESLFQYEREKTEGVVSIKE 812
            C+HLKE  +QYE EK E  V +++
Sbjct: 1200 CNHLKERQYQYENEKAEREVVVRQ 1223



 Score =  230 bits (586), Expect = 5e-60
 Identities = 130/308 (42%), Positives = 183/308 (59%), Gaps = 44/308 (14%)

Query: 11  GQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTA 70
           G+  +G+    Y+  GY +RD +L KIH+AA  G+ A+V++ L  R   L+  DK +RTA
Sbjct: 28  GEPGEGA----YSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTA 83

Query: 71  LHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLEHGANPNLKD 130
           LHLACA+GH +VVTLLV+RKCQ++VCD ENRT L++AV CQEE CA ILLEHGA+PNL D
Sbjct: 84  LHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLAD 143

Query: 131 IYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKMVEFLLKRKA 190
           ++GNTALHYAVY+E  S+A KLL + A+IEA +KD+ TPLL A+  KK++MVEFL+K+KA
Sbjct: 144 VHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203

Query: 191 SSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQ 250
           + +AVD+L  S  +++ Y                           ++  I  H ++    
Sbjct: 204 NVNAVDKLESSHQLISEY---------------------------KEERIPKHSSQNSNS 236

Query: 251 ILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCVPEKVSEPLP 310
           + E  +  L +     G               DS P SDD+DLN  TK      +++ + 
Sbjct: 237 VDESSEDSLSRLSGKPGVD-------------DSWPTSDDEDLNFDTKNVPKPSLAKLMT 283

Query: 311 GSSHEKGN 318
            S   + N
Sbjct: 284 ASQQSRKN 291



 Score =  107 bits (267), Expect = 4e-23
 Identities = 152/666 (22%), Positives = 280/666 (42%), Gaps = 111/666 (16%)

Query: 262  EKSDVGS--SDESAVSIFHELRVDSLP-ASDDKDLNVATKQCVPE-KVSEPLPGSSHEKG 317
            ++ D+ S    ES    F +  VD L  A+D K+ N+  +Q      +   + GS + K 
Sbjct: 412  QEEDIESPWDSESISENFPQKYVDPLAGAADGKEKNIGNEQAEDVFYIPSCMSGSRNFKM 471

Query: 318  NRIVNGQGEGPPAKHPS-------LKPSTEVEDPAVKGAVQRKNVQTLRA-EQALPVASE 369
             ++ + +  G P  H         LKP+ E++D     A   K+VQT +A E  L VASE
Sbjct: 472  AKLEDTRNVGMPVAHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAAEHDLEVASE 531

Query: 370  EEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAA-----GRLTQQRKIGKT 424
            EEQER E SE  QPQV+E    +++ ++++S NI D  +  A        L Q+RK G+T
Sbjct: 532  EEQER-EGSENNQPQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGET 590

Query: 425  YPQQFPKKLKEEHD-----------RCTLKQENEEKTNVNM-LYKK-------------- 458
              QQFP+K  +E+            + T K++   K +VN  ++ K              
Sbjct: 591  DHQQFPRKENKEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDD 650

Query: 459  -NREELERKEKQYKKEV--EAKQLEPTVQSLE------MKSKTAR---NTPNRDFHNHE- 505
             +  E++  E +  K+   E  +++  +QS++        S+TA      P+  + N   
Sbjct: 651  SSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFML 710

Query: 506  --EMKGL--MDENCILK-ADIAILRQEICTMKNDNLE-----------KENKYLKDIKIV 549
              E  G+   D   +LK  D A+  + +  +K ++ E           K N   +++   
Sbjct: 711  LIEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSET 770

Query: 550  KETNAALEKYIKLNEEMITETAFRYQQE----------LNDLKAENTRLNAELLKEKESK 599
            KE  + LE      E  +    F   QE             ++ +  R   +  KE E K
Sbjct: 771  KEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVK 830

Query: 600  KRLEADIESYQSRLAAAISKHSESVKTERNLKLALER------------TRDVSVQVEMS 647
            ++LE  +++ +  L    S  ++ V+   + +  L R            T  +S Q E+ 
Sbjct: 831  QQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIE 890

Query: 648  SAISKVKDENEFLTEQLSETQIKFNALKDKFRKTR---DSLRKKSLALE-TVQNDLSQTQ 703
             A  K+  EN    E+  +   K + L+++    R   D+++ ++   E     DL   +
Sbjct: 891  MAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVK 950

Query: 704  QQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTN 763
            ++ +++++  +  E  +  +  ++N    R+  L  ENA L  +L++  Q ++  E    
Sbjct: 951  EKNEDLQKTIKQNEETLTQTISQYN---GRLSVLTAENAMLNSKLENEKQSKERLEAEVE 1007

Query: 764  IQRGFIESGKKDLVLEEKSKKLM--------NECDHLKESLFQYEREKTEGVVSIKEDKY 815
                 + +   D    E SK+ +        +EC  L++ +  ++    +    I   + 
Sbjct: 1008 SYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKM-NFDVSNLKDNNEILSQQL 1066

Query: 816  FQTSRK 821
            F+T  K
Sbjct: 1067 FKTESK 1072



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 101/480 (21%), Positives = 193/480 (40%), Gaps = 47/480 (9%)

Query: 350  VQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSS 409
            VQ+   QT    + +    + EQ +  +   KQ  V+E  +  +SE + L + + D+ + 
Sbjct: 1097 VQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNK 1156

Query: 410  AAAGRLTQQRKIGKTYPQQFP---KKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERK 466
            A       + K       QF    +KL+ E ++ +L  E   K  ++        + + +
Sbjct: 1157 A-----DNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYE 1211

Query: 467  EKQYKKEVEAKQLE----PTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDE-----NCIL 517
             ++ ++EV  +QL+     T++   M   +   T     +  +E + L  +     N + 
Sbjct: 1212 NEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQ 1271

Query: 518  KADIAILRQEICTMK----NDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFR 573
            +A         C  K       LEK+N  LK + + K+ +   E    L    ++E    
Sbjct: 1272 EAQDRHTEAVRCAEKMQDHKQKLEKDNAKLK-VTVKKQMDKIEELQKNLLNANLSEDEKE 1330

Query: 574  YQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTERNLKLA 633
              ++L +LK     L   L +E +    LE +I  +++ L     K +E    E +    
Sbjct: 1331 QLKKLMELKQS---LECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGD 1387

Query: 634  LERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKDKFRKTRDSLRKKSLALE 693
            L+ +     Q EM   I+K+K + + LT +L     K   L  K       L+++ L+++
Sbjct: 1388 LKTS-----QFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTK----NQILQEELLSMK 1438

Query: 694  TVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCV-------EERICH-----LQREN 741
            TVQ    + Q+  +++++   N  + +  +  +   V       EER        L+  N
Sbjct: 1439 TVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVN 1498

Query: 742  AWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKESLFQYER 801
             +L  Q       E  +E      +  +E   KDL   E SK   ++ D  K  L +Y++
Sbjct: 1499 LFLQAQAASQENLEQFRENNFASMKSQMELRIKDLE-SELSKIKTSQEDFNKTELEKYKQ 1557



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 88/456 (19%), Positives = 184/456 (40%), Gaps = 89/456 (19%)

Query: 445  ENEEKTN-VNMLYKKNREELERKEKQYKK-EVEAKQLEPTVQSLEMKSKTARNTPNRDFH 502
            + E K N + + +   R+ L  K    ++ + +  Q +  ++ +E K +  +   N+   
Sbjct: 1068 KTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIG 1127

Query: 503  NHEEMKGLMDENCILKADIAILRQEICTMKN--DNLEKENKYLKDI--KIVKETNAALEK 558
              E ++  + +   L+++  +LRQ++    N  DN EK    ++D    IV++  A  EK
Sbjct: 1128 KQESVEERLSQ---LQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEK 1184

Query: 559  YIKL----NEEMITET------AFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIE- 607
               L    N+E+I+E        ++Y+ E  + +    +L  EL    + +   EA +E 
Sbjct: 1185 QSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEV 1244

Query: 608  --------------------SYQSRLAAAISKHSESVKTERNL---KLALERTRDVSVQV 644
                                  +++L  A  +H+E+V+    +   K  LE+  +  ++V
Sbjct: 1245 TSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKD-NAKLKV 1303

Query: 645  EMSSAISKVKDE-----NEFLTEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDL 699
             +   + K+++      N  L+E   E   K   LK       D   KK++ LE      
Sbjct: 1304 TVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGF 1363

Query: 700  SQTQQQTQEMKEMYQNAE----------------------AKVNNSTGKWNCVEERICHL 737
                + T++    Y+N E                       K+++ T +      +  HL
Sbjct: 1364 KNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHL 1423

Query: 738  QRENAWLVQQLDDV------------HQKEDHKEIV---TNIQRGFIESGKKDLVLEEKS 782
              +N  L ++L  +            ++K+  +E++   ++I+R  +E G+     +E  
Sbjct: 1424 DTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIE 1483

Query: 783  KKLMNE-CDHLKE-SLF-QYEREKTEGVVSIKEDKY 815
            ++   E  + LKE +LF Q +    E +   +E+ +
Sbjct: 1484 ERARQEIAEKLKEVNLFLQAQAASQENLEQFRENNF 1519


>gi|115495445 ankyrin repeat domain 30A [Homo sapiens]
          Length = 1341

 Score =  283 bits (725), Expect = 4e-76
 Identities = 186/525 (35%), Positives = 289/525 (55%), Gaps = 51/525 (9%)

Query: 328  PPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQERHE---------RS 378
            PP K  + +P+ E++      A++ KN QTLRA+Q  P  SE +Q++ E         R 
Sbjct: 817  PPEKPSAFEPAIEMQKSVPNKALELKNEQTLRADQMFP--SESKQKKVEENSWDSESLRE 874

Query: 379  EKKQPQVKEGNNTNKSEKIQLSENICDSTSSAA----------------------AGRLT 416
               Q  V     T++ E  ++S  + DSTS +                        G++ 
Sbjct: 875  TVSQKDVCVPKATHQKEMDKISGKLEDSTSLSKILDTVHSCERARELQKDHCEQRTGKME 934

Query: 417  QQRKI----------GKTYPQQFP-KKLKEEHDRC----TLKQENEEKTNVNMLYKKNRE 461
            Q +K            K    Q   +K+K E + C    TL QE E++ N ++L +K RE
Sbjct: 935  QMKKKFCVLKKKLSEAKEIKSQLENQKVKWEQELCSVRLTLNQEEEKRRNADILNEKIRE 994

Query: 462  ELERKEKQYKKEVEAKQ-LEPTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCILKAD 520
            EL R E+Q++KE+E KQ LE  ++  +++ K+  +  N+  H HE    L+ ENC+LK +
Sbjct: 995  ELGRIEEQHRKELEVKQQLEQALRIQDIELKSVESNLNQVSHTHENENYLLHENCMLKKE 1054

Query: 521  IAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELND 580
            IA+L+ EI T+K+   EKENKY +DIKI+KE NA L+  +KL EE +T+ A +Y  +L  
Sbjct: 1055 IAMLKLEIATLKHQYQEKENKYFEDIKILKEKNAELQMTLKLKEESLTKRASQYSGQLKV 1114

Query: 581  LKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRDV 640
            L AENT L ++L KEK+ K+ LEA+IES+  RLA+A+  H + V + ++ + A     D 
Sbjct: 1115 LIAENTMLTSKL-KEKQDKEILEAEIESHHPRLASAVQDHDQIVTSRKSQEPAFHIAGDA 1173

Query: 641  SVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLS 700
             +Q +M+  +S     NE L + LSE Q K  +LK       D+LR+ +L  E  Q D  
Sbjct: 1174 CLQRKMNVDVSSTIYNNEVLHQPLSEAQRKSKSLKINLNYAGDALRENTLVSEHAQRDQR 1233

Query: 701  QTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEI 760
            +TQ Q +E + MYQN +  VN  T +   +++++  LQ +N WL QQL   H+K D+K  
Sbjct: 1234 ETQCQMKEAEHMYQNEQDNVNKHTEQQESLDQKLFQLQSKNMWLQQQLVHAHKKADNKSK 1293

Query: 761  VTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKESLFQYEREKTE 805
            +T I   F+E   +  +L+EK++++ N  +HLK  ++QYE+EK E
Sbjct: 1294 IT-IDIHFLERKMQHHLLKEKNEEIFNYNNHLKNRIYQYEKEKAE 1337



 Score =  225 bits (574), Expect = 1e-58
 Identities = 167/499 (33%), Positives = 256/499 (51%), Gaps = 63/499 (12%)

Query: 55  RRSGDLDALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEA 114
           +++ +L+  D Q RTALH AC +GH +VVT LV+RKCQ+DV D E+RTPL++A+ C +EA
Sbjct: 5   KKTINLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEA 64

Query: 115 CAVILLEHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAI 174
           CA IL++ GA+ NL D+YGNTALHYAVYSE  S+  KLLSHGA IE  +K + TPLL +I
Sbjct: 65  CANILIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSI 124

Query: 175 ICKKEKMVEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRD 234
             + E++VEFLL + A+++AV++ + +ALMLAV + S  IV +LL+QN+DVFA D+CG  
Sbjct: 125 TKRSEQIVEFLLIKNANANAVNKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAADICGVT 184

Query: 235 AEDYAISHHLTKIQQQILEHKKKILKK------EKSDVGSSDE----------SAVSIFH 278
           AE YA++     I +QI+E+ +K+ K       E +  G+ DE          +A S+  
Sbjct: 185 AEHYAVTCGFHHIHEQIMEYIRKLSKNHQNTNPEGTSAGTPDEAAPLAERTPDTAESLVE 244

Query: 279 ELRVDSLPASD-DKDLNVATKQCVPEKVSEPLPGSSHE-------KGNRIVNGQGEGP-- 328
           +   ++ P  +   D   +  +  P++ +  + G+S +          +      E P  
Sbjct: 245 KTPDEAAPLVERTPDTAESLVEKTPDEAASLVEGTSDKIQCLEKATSGKFEQSAEETPRE 304

Query: 329 ---PAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASE------EEQERHERSE 379
              PAK  S K +   +    K A ++K              SE      + + R    E
Sbjct: 305 ITSPAKETSEKFTWPAKGRPRKIAWEKKEDTPREIMSPAKETSEKFTWAAKGRPRKIAWE 364

Query: 380 KKQPQVKEG-------NNTNKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKK 432
           KK+  VK G       N T   EK +     C +  S+       QR         FP +
Sbjct: 365 KKETPVKTGCVARVTSNKTKVLEKGRSKMIACPTKESSTKASANDQR---------FPSE 415

Query: 433 LKEEHDR---CTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLEPTV--QSLE 487
            K+E D    C  +   E    + +      E + +K  +  +EVE    +P+    ++E
Sbjct: 416 SKQEEDEEYSCDSRSLFESSAKIQVCIP---ESIYQKVMEINREVEEPPKKPSAFKPAIE 472

Query: 488 MKSKTARNTPNRDFHNHEE 506
           M++    + PN+ F    E
Sbjct: 473 MQN----SVPNKAFELKNE 487



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 122/602 (20%), Positives = 234/602 (38%), Gaps = 76/602 (12%)

Query: 250 QILEHKKKILKKEKSDV---GSSDESAVSIFHELRVDSLPASDDKDLNVATKQCVPE--- 303
           ++  +K K+L+K +S +    + + S  +  ++ R  S    ++ +      + + E   
Sbjct: 377 RVTSNKTKVLEKGRSKMIACPTKESSTKASANDQRFPSESKQEEDEEYSCDSRSLFESSA 436

Query: 304 KVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQA 363
           K+   +P S ++K   I N + E PP K  + KP+ E+++     A + KN QTLRA+  
Sbjct: 437 KIQVCIPESIYQKVMEI-NREVEEPPKKPSAFKPAIEMQNSVPNKAFELKNEQTLRADPM 495

Query: 364 LPVASEEE--QERHERSEK-----KQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLT 416
            P  S+++  +E    SE       Q  V     T++ E  +++  + +S +     + T
Sbjct: 496 FPPESKQKDYEENSWDSESLCETVSQKDVCLPKATHQKEIDKINGKLEESPNKDGLLKAT 555

Query: 417 QQRKIGKTYPQQFPKKLKEEHDRCTLKQENEEKTNV-------------NMLYKKNREEL 463
              K+        P K  E  D  T K E   K +                L  KN + L
Sbjct: 556 CGMKV------SIPTKALELKDMQTFKAEPPGKPSAFEPATEMQKSVPNKALELKNEQTL 609

Query: 464 --------ERKEKQYKKEV-EAKQLEPTVQSLEMKSKTARNTPNRDFHNHE-----EMKG 509
                   E K+K Y++   + + L  TV   ++    A +    D  N +        G
Sbjct: 610 RADEILPSESKQKDYEENSWDTESLCETVSQKDVCLPKAAHQKEIDKINGKLEGSPVKDG 669

Query: 510 LMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITE 569
           L+  NC +K  I     E+  M+    E   K       ++   +   K ++L  E    
Sbjct: 670 LLKANCGMKVSIPTKALELMDMQTFKAEPPEKPSAFEPAIEMQKSVPNKALELKNEQTLR 729

Query: 570 TAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTERN 629
                  E      E +  ++E L E  S+K +     ++Q  +     K  ES   +  
Sbjct: 730 ADEILPSESKQKDYEESSWDSESLCETVSQKDVCLPKATHQKEIDKINGKLEESPDNDGF 789

Query: 630 LKLALERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKDKFRKTRDSLRKKS 689
           LK          ++V + +   ++ D   F  E   +      A+     + + S+  K+
Sbjct: 790 LKAPCR------MKVSIPTKALELMDMQTFKAEPPEKPSAFEPAI-----EMQKSVPNKA 838

Query: 690 LALETVQ----NDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVE--------ERICHL 737
           L L+  Q    + +  ++ + ++++E   ++E+     + K  CV         ++I   
Sbjct: 839 LELKNEQTLRADQMFPSESKQKKVEENSWDSESLRETVSQKDVCVPKATHQKEMDKISGK 898

Query: 738 QRENAWLVQQLDDVHQKEDHKEIVTN---IQRGFIESGKKDLVLEEKSKKLMNECDHLKE 794
             ++  L + LD VH  E  +E+  +    + G +E  KK   +    KK ++E   +K 
Sbjct: 899 LEDSTSLSKILDTVHSCERARELQKDHCEQRTGKMEQMKKKFCV---LKKKLSEAKEIKS 955

Query: 795 SL 796
            L
Sbjct: 956 QL 957


>gi|222537750 ankyrin repeat domain 30B [Homo sapiens]
          Length = 1392

 Score =  273 bits (699), Expect = 4e-73
 Identities = 182/545 (33%), Positives = 298/545 (54%), Gaps = 30/545 (5%)

Query: 283  DSLPASDDKDLNVATKQCVPEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVE 342
            D+   SD + ++V+  Q       E LP ++++K  +  NG+ E  P K    +P+TE++
Sbjct: 869  DTKSTSDSEIISVSDTQNY-----ECLPEATYQKEIKTTNGKIEESPEKPSHFEPATEMQ 923

Query: 343  DPAVKGAVQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSEN 402
            +      ++ KN QTLRA+        +     ER      ++K+ N    + K++ ++N
Sbjct: 924  NSVPNKGLEWKNKQTLRADSTTLSKILDALPSCERGR----ELKKDNCEQITAKMEQTKN 979

Query: 403  ICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDRC----TLKQENEEKTNVNMLYKK 458
                        L++ ++I      Q   K K E + C    TL QE E++ NV++L +K
Sbjct: 980  ----KFCVLQKELSEAKEIKSQLENQ---KAKWEQELCSVRLTLNQEEEKRRNVDILKEK 1032

Query: 459  NREELERKEKQYKKEVEAKQ-LEPTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCIL 517
             R E     +Q +K++E KQ LE T++  +++ K+  +  N+  H HE    L  ENC+L
Sbjct: 1033 IRPE-----EQLRKKLEVKQQLEQTLRIQDIELKSVTSNLNQVSHTHESENDLFHENCML 1087

Query: 518  KADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQE 577
            K +IA+L+ E+ T+K+ +  KENKY +DIKI++E NA L+  +KL ++ +T+ A +Y+++
Sbjct: 1088 KKEIAMLKLEVATLKHQHQVKENKYFEDIKILQEKNAELQMTLKLKQKTVTKRASQYREQ 1147

Query: 578  LNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTERNLKLALERT 637
            L  L AENT L ++L KEK+ K+ LE +IES+  RLA+A+  H +SV + +N +LA    
Sbjct: 1148 LKVLTAENTMLTSKL-KEKQDKEILETEIESHHPRLASALQDHDQSVTSRKNQELAFHSA 1206

Query: 638  RDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQN 697
             D  +Q  M+  +S     NE L + L E Q K  + K       D LR+ +L  E  Q 
Sbjct: 1207 GDAPLQGIMNVDVSNTIYNNEVLHQPLYEAQRKSKSPKINLNYAGDDLRENALVSEHAQR 1266

Query: 698  DLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDH 757
            D  +TQ Q ++ + MYQN +  V+  T +   +E+++  L+ +N WL QQL   H+K + 
Sbjct: 1267 DRCETQCQMKKAEHMYQNEQDNVDKHTEQQESLEQKLFQLESKNRWLRQQLVYAHKKVNK 1326

Query: 758  KEIVTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKESLFQYEREKTEGVVSIKEDKYFQ 817
             ++  NIQ       K    L EK++++ N  +HLKE + QYE+EK E  VSIK+ KYF 
Sbjct: 1327 SKVTINIQ---FPEMKMQRHLNEKNEEVFNYGNHLKERIDQYEKEKAEREVSIKKYKYFS 1383

Query: 818  TSRKK 822
               K+
Sbjct: 1384 NFLKE 1388



 Score =  224 bits (571), Expect = 3e-58
 Identities = 182/547 (33%), Positives = 277/547 (50%), Gaps = 63/547 (11%)

Query: 5   GFGSRRGQTAQGSIDHVYTGSGY-RIRDSELQKIHRAAVKGDAAEVERC-LARRSGDLDA 62
           G G R  +      + VYT   Y  I   +L KIH AA +G   ++E+  + ++  +L+ 
Sbjct: 9   GKGVRGPEPPNPFSERVYTEKDYGTIYFGDLGKIHTAASRGQVQKLEKMTVGKKPVNLNK 68

Query: 63  LDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLEH 122
            D + RTALH AC +GH +VVT LV+RKCQ++V D E RTPL++A+ C+ EACA IL++ 
Sbjct: 69  RDMKKRTALHWACVNGHAEVVTFLVDRKCQLNVLDGEGRTPLMKALQCEREACANILIDA 128

Query: 123 GANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKMV 182
           GA+ N  D+YGNTALHYAVYSE+  +   LLS+GA IE  +K + TPLL AI  + ++ V
Sbjct: 129 GADLNYVDVYGNTALHYAVYSENLLMVATLLSYGAVIEVQNKASLTPLLLAIQKRSKQTV 188

Query: 183 EFLLKRKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAISH 242
           EFLL + A+++A +  + +ALMLA+   S  IV +LL+QN+DVFA+D+ G  AE YA + 
Sbjct: 189 EFLLTKNANANAFNESKCTALMLAICEGSSEIVGMLLQQNVDVFAEDIHGITAERYAAAC 248

Query: 243 HLTKIQQQILEHKKKILKK------EKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVA 296
            +  I QQ+LEH +K+ K       E +  G+ DE+A     E   D+  +  +K  + A
Sbjct: 249 GVNYIHQQLLEHIRKLPKNPQNTNPEGTSTGTPDEAAP--LAERTPDTAESLLEKTPDEA 306

Query: 297 TK---------QCVPEKVSEPLPGSSHEKGNRIVNGQGEGP-----PAKHPSLKPSTEVE 342
            +         QC+ +  S     S+ E   +I+    E       PAK  S K + E +
Sbjct: 307 ARLVEGTSAKIQCLGKATSGKFEQSTEETPRKILRPTKETSEKFSWPAKERSRKITWEEK 366

Query: 343 DPAVK----GAVQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQVKE------GNNT- 391
           + +VK      V     + L    +  +A   ++   + S        E      G  T 
Sbjct: 367 ETSVKTECVAGVTPNKTEVLEKGTSNMIACPTKETSTKASTNVDVSSVEPIFSLFGTRTI 426

Query: 392 --NKSEKIQLSENICDSTSSAAAGR-------LTQQRKI----GKTYPQQFPKKLKEEHD 438
             ++  K++   N+     S +A +        T Q+ I     K   Q FP + K E D
Sbjct: 427 ENSQCTKVEEDFNLATKIISKSAAQNYTCLPDATYQKDIKTINHKIEDQMFPSESKREED 486

Query: 439 R-----CTLKQENEEKTNV---NMLYKK----NR--EELERKEKQYKKEVEAKQLEPTVQ 484
                      E+  KT V     +Y+K    NR  EEL  K   +K  VE ++  P  +
Sbjct: 487 EEYSWDSGSLFESSAKTQVCIPESMYQKVMEINREVEELPEKPSAFKPAVEMQKTVPN-K 545

Query: 485 SLEMKSK 491
           + E+K++
Sbjct: 546 AFELKNE 552



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 97/464 (20%), Positives = 178/464 (38%), Gaps = 55/464 (11%)

Query: 309  LPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQALPVAS 368
            LP ++H+K    ++G+ E  P K   LKP+  ++      A++ K+ +T +AE    V S
Sbjct: 744  LPKATHQKEFDTLSGKLEESPDKDGLLKPTCGMKISLPNKALELKDRETFKAEDVSSVES 803

Query: 369  EEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKIG--KTYP 426
                     +E  Q           S K++   N+     +       Q+R IG  +  P
Sbjct: 804  TFSLFGKPTTENSQ-----------STKVEEDFNLTTKEGATKTVTGQQERDIGIIERAP 852

Query: 427  QQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELE-RKEKQYKKEVEAKQLEPTVQS 485
            Q    K+         K++ +  ++  ++   + +  E   E  Y+KE+  K     ++ 
Sbjct: 853  QDQTNKMPT--SELGRKEDTKSTSDSEIISVSDTQNYECLPEATYQKEI--KTTNGKIE- 907

Query: 486  LEMKSKTARNTPNRDFHNHEEMKGLMDEN-CILKADIAILRQEICTMKNDNLEKENKYLK 544
             E   K +   P  +  N    KGL  +N   L+AD   L + +  + +    +E K   
Sbjct: 908  -ESPEKPSHFEPATEMQNSVPNKGLEWKNKQTLRADSTTLSKILDALPSCERGRELKKDN 966

Query: 545  DIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEA 604
              +I  +      K+  L +E+      + Q E    K E    +  L   +E +KR   
Sbjct: 967  CEQITAKMEQTKNKFCVLQKELSEAKEIKSQLENQKAKWEQELCSVRLTLNQEEEKRRNV 1026

Query: 605  DIESYQSRLAAAISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFLTEQL 664
            DI               E ++ E  L+  LE    V  Q+E +  I  +  E + +T  L
Sbjct: 1027 DI-------------LKEKIRPEEQLRKKLE----VKQQLEQTLRIQDI--ELKSVTSNL 1067

Query: 665  SETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMK-------------E 711
            ++      +  D F +  + + KK +A+  ++    + Q Q +E K             E
Sbjct: 1068 NQVSHTHESENDLFHE--NCMLKKEIAMLKLEVATLKHQHQVKENKYFEDIKILQEKNAE 1125

Query: 712  MYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKE 755
            +    + K    T + +   E++  L  EN  L  +L +   KE
Sbjct: 1126 LQMTLKLKQKTVTKRASQYREQLKVLTAENTMLTSKLKEKQDKE 1169



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 113/557 (20%), Positives = 205/557 (36%), Gaps = 69/557 (12%)

Query: 297  TKQCVPEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQ 356
            T+ C+PE + + +           +N + E  P K  + KP+ E++      A + KN Q
Sbjct: 503  TQVCIPESMYQKVME---------INREVEELPEKPSAFKPAVEMQKTVPNKAFELKNEQ 553

Query: 357  TLRAEQALPVASEEEQERHERSEKKQP-------QVKEGNNTNKSEKIQLSENICDSTSS 409
            TLRA Q  P  S+++ +     + + P        V     T++ E   LS  + +S   
Sbjct: 554  TLRAAQMFPSESKQKDDEENSWDSESPCETVSQKDVYLPKATHQKEFDTLSGKLEESPVK 613

Query: 410  AAAGRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERKEKQ 469
                + T  RK+        P K  E  DR T K E+ +K  +       +  L  K  +
Sbjct: 614  DGLLKPTCGRKV------SLPNKALELKDRETFKAESPDKDGLLKPTCGRKVSLPNKALE 667

Query: 470  YKKEVEAKQLEPTVQSLEMKSKTAR--NTPNRDFHNHEEMKGLMDENCILKADIAILRQE 527
             K     K   P    L +K    R  + PN+          L D      A +     +
Sbjct: 668  LKDRETLKAESPDNDGL-LKPTCGRKVSLPNKALE-------LKDRETFKAAQMFPSESK 719

Query: 528  ICTMKNDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTR 587
                + D+ E    +   ++ + + +  L K     E            + + L      
Sbjct: 720  ----QKDDEENSWDFESFLETLLQNDVCLPKATHQKEFDTLSGKLEESPDKDGLLKPTCG 775

Query: 588  LNAEL------LKEKESKKRLE-ADIESYQSRLAAAISKHSESVKTERNLKLALER--TR 638
            +   L      LK++E+ K  + + +ES  S      +++S+S K E +  L  +   T+
Sbjct: 776  MKISLPNKALELKDRETFKAEDVSSVESTFSLFGKPTTENSQSTKVEEDFNLTTKEGATK 835

Query: 639  DVSVQVEMSSAI---SKVKDENEFLTEQLSETQIKFNALKDKFRKTRDSLRKKSLALETV 695
             V+ Q E    I   +     N+  T +L   +   +    +     D+   + L   T 
Sbjct: 836  TVTGQQERDIGIIERAPQDQTNKMPTSELGRKEDTKSTSDSEIISVSDTQNYECLPEATY 895

Query: 696  QNDLSQTQQQTQEMKEMYQNAE--AKVNNSTGKWNCVEERICHLQRENAWLVQQLDDV-- 751
            Q ++  T  + +E  E   + E   ++ NS        +    L+ ++  L + LD +  
Sbjct: 896  QKEIKTTNGKIEESPEKPSHFEPATEMQNSVPNKGLEWKNKQTLRADSTTLSKILDALPS 955

Query: 752  -----HQKEDHKEIVTN-----------IQRGFIESGKKDLVLEEKSKKLMNECDHLKES 795
                   K+D+ E +T            +Q+   E+ +    LE +  K   E   ++ +
Sbjct: 956  CERGRELKKDNCEQITAKMEQTKNKFCVLQKELSEAKEIKSQLENQKAKWEQELCSVRLT 1015

Query: 796  LFQYEREKTEGVVSIKE 812
            L Q E EK   V  +KE
Sbjct: 1016 LNQ-EEEKRRNVDILKE 1031


>gi|149363642 coiled-coil domain containing 144A [Homo sapiens]
          Length = 1427

 Score =  273 bits (699), Expect = 4e-73
 Identities = 188/490 (38%), Positives = 273/490 (55%), Gaps = 67/490 (13%)

Query: 397  IQLSENICDSTS----------SAAAGRLTQQRKIGKTYPQQFPKKLKEEHD-RCTLKQE 445
            ++L  N CD  +          S     L++ +K       Q  +  KE +D R  LKQE
Sbjct: 649  LKLKNNHCDQLTVKLKQMENMVSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQE 708

Query: 446  NEEKTNVNMLYKKNREELERKEKQYKKEVEAKQ-------------------LEPTVQ-- 484
            NEEK N +MLY K+ E+L  KE++  K VE KQ                   L+  VQ  
Sbjct: 709  NEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQER 768

Query: 485  ----------------------SLEMKSKTARNTPNRDF-HNHEEMKGLMDENCILKADI 521
                                  S + + + AR   N +  H H++ K L  E+C+L+ +I
Sbjct: 769  NDAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEI 828

Query: 522  AILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDL 581
            A+LR EI T+KN N +KE KY +DI+ VKE N  L+K IKLNEE +TET  +Y  +LN+L
Sbjct: 829  ALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNL 888

Query: 582  KAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRD-- 639
             AEN  LN+EL   K++++RLE ++ESY+ RLAAA+    +S +T R+LKL  +RTR   
Sbjct: 889  TAENKILNSELENGKQNQERLEIEMESYRCRLAAAVRDCDQS-QTARDLKLDFQRTRQEW 947

Query: 640  VSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDL 699
            V +  +M   +S ++ +NE L+E+LS  + K N+L+ +   TRD+L ++SL LE VQ DL
Sbjct: 948  VRLHDKMKVDMSGLQAKNEILSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQRDL 1007

Query: 700  SQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKE 759
            SQTQ Q +E ++MYQ  ++K+     K   VEER+  LQ EN  L QQLDD H+K + +E
Sbjct: 1008 SQTQCQKKETEQMYQIEQSKLKKYIAKQESVEERLSQLQSENMLLRQQLDDAHKKANSQE 1067

Query: 760  IVTN-IQRGF--------IESGKKDLVLEEKSKKLMNECDHLKESLFQYEREKTEGVVSI 810
              ++ IQ  F         ES K+ L L+EK+K+LM+E +HLKE + Q E+EK    + +
Sbjct: 1068 KTSSTIQDQFHSAAKNLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDL 1127

Query: 811  KEDKYFQTSR 820
             E +    SR
Sbjct: 1128 TEAQETVPSR 1137



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 100/483 (20%), Positives = 199/483 (41%), Gaps = 84/483 (17%)

Query: 363 ALPVASEEEQERHERSEKKQPQVKEGNNTN---------KSEKIQLSENICD------ST 407
           +LP  S+   E +   E +Q   K  N  N         K E +QL +++ +      S 
Sbjct: 478 SLPPDSDRTSEVYLHEELQQDMQKFKNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSN 537

Query: 408 SSAAAGRLTQQRKIGKT---YPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELE 464
           S+  +G LT    +G       QQ P+K   EHDR   K  NE+    N +Y     E +
Sbjct: 538 STELSGTLTDGTTVGNDDDGLNQQIPRKENGEHDRPADKTSNEKNEVKNQIY----PEAD 593

Query: 465 RKEKQYKKEVEAKQLEPT----------VQSLEMKSKTARNTPNRDFHNHEEMKGLMDEN 514
             +     E+ ++  E +          ++ L M+ K + + P            + D  
Sbjct: 594 FADSMEPSEIASEDCELSHSVYENFMLLIEQLRMEYKDSASLPR-----------IQDTF 642

Query: 515 CILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFRY 574
           C+ +  +  L+   C    D L  + K ++++  V +   +  K  KL  E+       +
Sbjct: 643 CLCE-HLLKLKNNHC----DQLTVKLKQMENMVSVLQNELSETKKTKLQLEL---QKIEW 694

Query: 575 QQELND----LKAEN-TRLNAELLKEKESKK-RLEAD----IESYQSRLAAAISKHSESV 624
           ++EL D    LK EN  + NA++L  K+S++ R++ +    +   + +L   + +  + +
Sbjct: 695 EKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKEL 754

Query: 625 KTER-NLKLALERTRDVSVQVE-------MSSAISKVKDENEFLTEQLSETQIKFNALKD 676
           +T R NL L ++   D   Q+        +   I   K +   +  +   ++I     K+
Sbjct: 755 RTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKE 814

Query: 677 KFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEA------------KVNNST 724
           K     D + ++ +AL  ++ D  + Q + +E K+ +++ EA            K+N  T
Sbjct: 815 KDLFHEDCMLQEEIALLRLEIDTIKNQNKQKE-KKYFEDIEAVKEKNDNLQKIIKLNEET 873

Query: 725 GKWNCVE--ERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEEKS 782
                ++   ++ +L  EN  L  +L++  Q ++  EI     R  + +  +D    + +
Sbjct: 874 LTETILQYSGQLNNLTAENKILNSELENGKQNQERLEIEMESYRCRLAAAVRDCDQSQTA 933

Query: 783 KKL 785
           + L
Sbjct: 934 RDL 936



 Score = 32.3 bits (72), Expect = 1.8
 Identities = 16/32 (50%), Positives = 21/32 (65%)

Query: 353 KNVQTLRAEQALPVASEEEQERHERSEKKQPQ 384
           +N ++  AEQ   + SEEEQER +  E KQPQ
Sbjct: 215 ENKESKEAEQDSELTSEEEQERLKGCENKQPQ 246


>gi|153791352 prostate, ovary, testis expressed protein on
           chromosome 2 [Homo sapiens]
          Length = 1075

 Score =  270 bits (691), Expect = 3e-72
 Identities = 204/606 (33%), Positives = 311/606 (51%), Gaps = 92/606 (15%)

Query: 19  DHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASG 78
           D  +    Y +R  +L K+HRAA  G     +  +  R  D++  DKQ RTALHLA A+G
Sbjct: 125 DSAFMEPRYHVRGEDLDKLHRAAWWGKVPRKDLIVMLRDTDVNKQDKQKRTALHLASANG 184

Query: 79  HVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALH 138
           + +VV LL++R+CQ++V D + RT LI+AV CQE+ CA++LLEHG +PN+ D YGNT LH
Sbjct: 185 NSEVVKLLLDRRCQLNVLDNKKRTALIKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLH 244

Query: 139 YAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKMVEFLLKRKASSHAVDRL 198
           YA+Y+E   +A+ LL +GA IE+ +K   TPLL  +  +K+++V+FL+K+KA+ +A+DR 
Sbjct: 245 YAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRY 304

Query: 199 RRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKI 258
            R+AL+LAV   S  IV++LL+QNIDV +QD+ G+ A +YA+S H   I Q + ++K+K 
Sbjct: 305 GRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQ 364

Query: 259 LKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCVPE-------KVSEPLPG 311
           + K  S+  S+ E  + +  E        S++      +++  PE       +V E +  
Sbjct: 365 MLKISSE-NSNPEQDLKLTSEEESQRFKGSENSQPEKMSQE--PEINKDGDREVEEEM-- 419

Query: 312 SSHEKGN-----RIVNG--QGEGPPAKHPSLKPST------------------EVEDPAV 346
             HE  N      + NG   G G     P  K  T                  E+     
Sbjct: 420 KKHESNNVGLLENLTNGVTAGNGDNGLIPQRKSRTPENQQFPDNESEEYHRICELLSDYK 479

Query: 347 KGAVQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQVK-------------------- 386
           +  + + + +    EQ L + SEEE +R + SE  QP+ +                    
Sbjct: 480 EKQMPKYSSENSNPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFMAI 539

Query: 387 EGNNTNKSEKIQLSENICDSTSSAAAGR----LTQQRKIGKTYPQQFPKKLKEEH----D 438
           E    ++S  +   EN+   T+ A AG     L   RK      QQFP    EE+     
Sbjct: 540 EEMKKHRSTHVGFPENL---TNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHSDEQ 596

Query: 439 RCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPN 498
             T KQ  EE+ N  +L+    E L  +EKQ    +E  +   +  SL  K +       
Sbjct: 597 NDTQKQFCEEQ-NTGILHD---EILIHEEKQ----IEVVEKMNSELSLSCKKE------- 641

Query: 499 RDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEK 558
                    K ++ EN  L+ +IA+LR E+ TMK+ +  +E KYL+DI+ VK+ N  L K
Sbjct: 642 ---------KDILHENSTLREEIAMLRLELDTMKHQSQLREKKYLEDIESVKKRNDNLLK 692

Query: 559 YIKLNE 564
            ++LNE
Sbjct: 693 ALQLNE 698


>gi|134133226 protein expressed in prostate, ovary, testis, and
           placenta 2 [Homo sapiens]
          Length = 1075

 Score =  270 bits (690), Expect = 4e-72
 Identities = 205/611 (33%), Positives = 308/611 (50%), Gaps = 102/611 (16%)

Query: 19  DHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASG 78
           D  +    Y +R  +L K+HRAA  G     +  +  R  D++  DKQ RTALHLA A+G
Sbjct: 125 DSAFMEPRYHVRGEDLDKLHRAAWWGKVPRKDLIVMLRDTDVNKKDKQKRTALHLASANG 184

Query: 79  HVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALH 138
           + +VV LL++R+CQ++V D + RT LI+AV CQE+ CA++LLEHG +PN+ D YGNT LH
Sbjct: 185 NSEVVKLLLDRRCQLNVLDNKKRTALIKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLH 244

Query: 139 YAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKMVEFLLKRKASSHAVDRL 198
           YA+Y+E   +A+ LL +GA IE+ +K   TPLL  +  +K+++V+FL+K+KA+ +A+DR 
Sbjct: 245 YAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRY 304

Query: 199 RRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKI 258
            R+AL+LAV   S  IV++LL+QNIDV +QD+ G+ A +YA+S H   I Q + ++K+K 
Sbjct: 305 GRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQ 364

Query: 259 LKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCVPEKVSEPL--------- 309
           + K  S+  S+ E  + +  E        S++           PEK+S+ L         
Sbjct: 365 MLKISSE-NSNPEQELKLTSEEESQRFKGSENSQ---------PEKMSQELEINKDGDRE 414

Query: 310 ---PGSSHEKGN-----RIVNG--QGEGPPAKHPSLKPST------------------EV 341
                  HE  N      + NG   G G     P  K  T                  E+
Sbjct: 415 VEEEMKKHESNNVGLLENLTNGVTAGNGDNGLIPQRKSRTPENQQFPDNESEEYHRICEL 474

Query: 342 EDPAVKGAVQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQVK--------------- 386
                +  + + + +    EQ L + SEEE +R + SE  QP+ +               
Sbjct: 475 LSDYKEKQMPKYSSENSNPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELE 534

Query: 387 -----EGNNTNKSEKIQLSENICDSTSSAAAGR----LTQQRKIGKTYPQQFPKKLKEEH 437
                E    + S  +   EN+   T+ A AG     L   RK      QQFP    EE+
Sbjct: 535 NFMAIEEMKKHGSTHVGFPENL---TNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEY 591

Query: 438 ----DRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKSKTA 493
                  T KQ  EE+ N  +L+    E L  +EKQ    +E  +   +  SL  K +  
Sbjct: 592 HSDEQNDTQKQFCEEQ-NTGILHD---EILIHEEKQ----IEVVEKMNSELSLSCKKE-- 641

Query: 494 RNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETN 553
                         K ++ EN  L+ +IA+LR E+ TMK+ +  +E KYL+DI+ VK+ N
Sbjct: 642 --------------KDVLHENSTLREEIAMLRLELDTMKHQSQLREKKYLEDIESVKKKN 687

Query: 554 AALEKYIKLNE 564
             L K ++LNE
Sbjct: 688 DNLLKALQLNE 698


>gi|113413200 PREDICTED: similar to protein expressed in prostate,
           ovary, testis, and placenta 2 [Homo sapiens]
          Length = 1038

 Score =  266 bits (681), Expect = 4e-71
 Identities = 205/606 (33%), Positives = 311/606 (51%), Gaps = 92/606 (15%)

Query: 19  DHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASG 78
           D  +    Y +R  +L K+HRAA  G  A  +  +  R  D++  DKQ RTALHLA A+G
Sbjct: 88  DSAFVEPRYHVRREDLDKLHRAAWWGKVARKDLIVMLRDTDVNKQDKQKRTALHLASANG 147

Query: 79  HVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALH 138
           +  VV LL++R+CQ++V D + RT L +AV CQE+ CA++LLEHG +PN+ D YGNT LH
Sbjct: 148 NSGVVKLLLDRRCQLNVLDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLH 207

Query: 139 YAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKMVEFLLKRKASSHAVDRL 198
           YA+Y+E   +A+ LL +GA IE+ +K   TPLL  +  +K+++V+FL+K+KA+ +A+DR 
Sbjct: 208 YAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRY 267

Query: 199 RRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKI 258
            R+AL+LAV   S  IV++LL+QNIDV +QD+ G+ A +YA+S H   I Q + ++K+K 
Sbjct: 268 GRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQ 327

Query: 259 LKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCVPE-------KVSEPLPG 311
           + K  S+  S+ E  + +  E        S++      +++  PE       +V E +  
Sbjct: 328 MLKISSE-NSNPEQDLKLTSEEESQRFKGSENSQPEKMSQE--PEINKDGDREVEEEM-- 382

Query: 312 SSHEKGN-----RIVNG--QGEGPPAKHPSLKPST------------------EVEDPAV 346
             HE  N      + NG   G G     P  K  T                  E+     
Sbjct: 383 KKHESNNVGLLENLSNGVTAGNGDDGLIPQRKSRTPENQQFPDNESEEYHRICELVSDYK 442

Query: 347 KGAVQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQVK-------------------- 386
           +  + + + +    EQ L + SEEE +R + SE  QP+ +                    
Sbjct: 443 EKQMPKYSSENSNPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFMAI 502

Query: 387 EGNNTNKSEKIQLSENICDSTSSAAAGR----LTQQRKIGKTYPQQFPKKLKEEH----D 438
           E    + S  +   EN+   T+ A AG     L   RK      QQFP    EE+     
Sbjct: 503 EEMKKHGSTHVGFPENL---TNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHSDEQ 559

Query: 439 RCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPN 498
             T KQ  EE+ N  +L+    E L  +EKQ    +E  +   +  SL  K +       
Sbjct: 560 NDTQKQFCEEQ-NTGILHD---EILIHEEKQ----IEVVEKMNSELSLSCKKE------- 604

Query: 499 RDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEK 558
           RDF         + EN +L+ +IA+LR E+ TMK+ +  ++ KYL+DI+ VK+ N  L K
Sbjct: 605 RDF---------LHENSMLREEIAMLRLELDTMKHQSQLRKKKYLEDIESVKKKNDNLLK 655

Query: 559 YIKLNE 564
            ++LNE
Sbjct: 656 ALQLNE 661


>gi|88953571 PREDICTED: similar to protein expressed in prostate,
           ovary, testis, and placenta 2 isoform 2 [Homo sapiens]
          Length = 1075

 Score =  265 bits (677), Expect = 1e-70
 Identities = 203/606 (33%), Positives = 308/606 (50%), Gaps = 92/606 (15%)

Query: 19  DHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASG 78
           D  +    Y +R  +L K+HRAA  G  A  +  +  R  D++  DKQ RTALHLA A+G
Sbjct: 125 DSAFVEPRYHVRREDLDKLHRAAWWGKVARKDLIVMLRDTDVNKQDKQKRTALHLASANG 184

Query: 79  HVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALH 138
           +  VV LL++R+CQ++V D + RT L +AV CQE+ CA++LLEHG +PN+ D YGNT LH
Sbjct: 185 NSGVVKLLLDRRCQLNVLDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLH 244

Query: 139 YAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKMVEFLLKRKASSHAVDRL 198
           YA+Y+E   +A+ LL +GA IE+ +K   TPLL  +  +K+++V+FL+K+KA+ +A+DR 
Sbjct: 245 YAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRY 304

Query: 199 RRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKI 258
            R+AL+LAV   S  IV++LL+QNIDV +QD+ G+ A +YA+S H   I Q + ++K+K 
Sbjct: 305 GRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQ 364

Query: 259 LKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCVPE-------KVSEPLPG 311
           + K  S+  S+ E  + +  E        S++      +++  PE       +V E +  
Sbjct: 365 MLKISSE-NSNPEQDLKLTSEEESQRFKGSENSQPEKMSQE--PEINKDGDREVEEEM-- 419

Query: 312 SSHEKGN-----RIVNG--QGEGPPAKHPSLKPST------------------EVEDPAV 346
             HE  N      + NG   G G     P  K  T                  E+     
Sbjct: 420 KKHESNNVGLLENLSNGVTAGNGDDGLIPQRKSRTPENQQFPDNESEEYHRICELVSDYK 479

Query: 347 KGAVQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQVK-------------------- 386
           +  + + + +    EQ L + SEEE +R + SE  QP+ +                    
Sbjct: 480 EKQMPKYSSENSNPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFMAI 539

Query: 387 EGNNTNKSEKIQLSENICDSTSSAAAGR----LTQQRKIGKTYPQQFPKKLKEEH----D 438
           E    + S  +   EN+   T+ A AG     L   RK      QQFP    EE+     
Sbjct: 540 EEMKKHGSTHVGFPENL---TNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHSDEQ 596

Query: 439 RCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPN 498
             T KQ  EE+ N  +L+    E L  +EKQ    +E  +   +  SL  K +       
Sbjct: 597 NDTQKQFCEEQ-NTGILHD---EILIHEEKQ----IEVVEKMNSELSLSCKKE------- 641

Query: 499 RDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEK 558
                    K  + EN  L+ +IA+LR E+ TMK+ +  ++ KYL+DI+ VK+ N  L K
Sbjct: 642 ---------KDFLHENSTLREEIAMLRLELDTMKHQSQLRKKKYLEDIESVKKKNDNLLK 692

Query: 559 YIKLNE 564
            ++LNE
Sbjct: 693 ALQLNE 698


>gi|239741769 PREDICTED: similar to protein expressed in prostate,
           ovary, testis, and placenta 2 [Homo sapiens]
          Length = 952

 Score =  248 bits (633), Expect = 2e-65
 Identities = 182/550 (33%), Positives = 282/550 (51%), Gaps = 103/550 (18%)

Query: 19  DHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASG 78
           D  +    Y +R  +L K+HRAA  G  A  +  +  R  D++  DKQ RTALHLA A+G
Sbjct: 125 DSAFVEPRYHVRREDLDKLHRAAWWGKVARKDLIVMLRDTDVNKQDKQKRTALHLASANG 184

Query: 79  HVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALH 138
           +  VV LL++R+CQ++V D + RT L +AV CQE+ CA++LLEHG +PN+ D YGNT LH
Sbjct: 185 NSGVVKLLLDRRCQLNVLDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLH 244

Query: 139 YAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKMVEFLLKRKASSHAVDRL 198
           YA+Y+E   +A+ LL +GA IE+ +K   TPLL  +  +K+++V+FL+K+KA+ +A+DR 
Sbjct: 245 YAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRY 304

Query: 199 RRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKI 258
            R+AL+LAV   S  IV++LL+QNIDV +QD+ G+ A +YA+S H   I Q + ++K+K 
Sbjct: 305 GRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQ 364

Query: 259 LKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCVPEKVSEPLPGSSHEKGN 318
           +                    L++ S  ++ ++DL + +     E+ S+   GS +    
Sbjct: 365 M--------------------LKISSENSNPEQDLKLTS-----EEESQRFKGSENS--- 396

Query: 319 RIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQERHERS 378
                            +P    ++P +     R+               EEE ++H  +
Sbjct: 397 -----------------QPEKMSQEPEINKDGDRE--------------VEEEMKKHGST 425

Query: 379 EKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEH- 437
               P+    N TN             +T+      L   RK      QQFP    EE+ 
Sbjct: 426 HVGFPE----NLTN------------GATAGNGDDGLIPPRKSRTPESQQFPDTENEEYH 469

Query: 438 ---DRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKSKTAR 494
                 T KQ  EE+ N  +L+    E L  +EKQ    +E  +   +  SL  K +   
Sbjct: 470 SDEQNDTQKQFCEEQ-NTGILHD---EILIHEEKQ----IEVVEKMNSELSLSCKKE--- 518

Query: 495 NTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNA 554
                        K  + EN  L+ +IA+LR E+ TMK+ +  ++ KYL+DI+ VK+ N 
Sbjct: 519 -------------KDFLHENSTLREEIAMLRLELDTMKHQSQLRKKKYLEDIESVKKKND 565

Query: 555 ALEKYIKLNE 564
            L K ++LNE
Sbjct: 566 NLLKALQLNE 575


>gi|239741786 PREDICTED: kappa-actin [Homo sapiens]
          Length = 924

 Score =  246 bits (628), Expect = 6e-65
 Identities = 186/554 (33%), Positives = 284/554 (51%), Gaps = 102/554 (18%)

Query: 19  DHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASG 78
           D  +    Y +   +L K+HRAA  G     +  +  R  D++  DKQ RTALHLA A+G
Sbjct: 88  DSAFMDPRYHVHGEDLDKLHRAAWWGKVPRKDLIVMLRDTDVNKRDKQKRTALHLASANG 147

Query: 79  HVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALH 138
           + +VV L+++R+CQ++V D + RT L +AV CQE+ CA++LLEHG +PN+ D YGNT LH
Sbjct: 148 NSEVVKLVLDRRCQLNVLDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLH 207

Query: 139 YAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKMVEFLLKRKASSHAVDRL 198
           YAVY+E   +A+ LL +GA IE+ +K   TPLL  I  +K+++V+FL+K+KA+ +A+DR 
Sbjct: 208 YAVYNEDKLMAKALLLYGADIESKNKHGLTPLLLGIHEQKQQVVKFLIKKKANLNALDRY 267

Query: 199 RRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKI 258
            R+AL+LAV   S  IV+ LL+QNIDV +QD  G+ A +YA+S H   I Q + ++K+K 
Sbjct: 268 GRTALILAVCCGSANIVSPLLEQNIDVSSQD-XGQTAREYAVSSHHHVICQLLSDYKEKQ 326

Query: 259 LKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCVPEKVSEPLPGSSHEKGN 318
           + K  S+  S+ E  + +  E     L  S++           PEK+S+           
Sbjct: 327 MLKISSE-NSNPEQDLKLTSEEESQKLKGSENSQ---------PEKMSQ----------E 366

Query: 319 RIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQERHERS 378
             +N  G+             E+ED                      +A EEE ++H   
Sbjct: 367 PEINKDGD------------RELED---------------------FMAIEEEMKKH--- 390

Query: 379 EKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGR----LTQQRKIGKTYPQQFPKKLK 434
                          S  +   EN+   T+ AAAG     L   RK      QQFP    
Sbjct: 391 --------------GSTHVGFPENL---TNGAAAGNGDDGLIPPRKSRTPESQQFPDTEN 433

Query: 435 EEH----DRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKS 490
           EE+       T KQ +EE+ N  +L     E L  +EKQ                +E+  
Sbjct: 434 EEYHSDEQNDTQKQLSEEQ-NTGIL---QDEILXHEEKQ----------------IEVAE 473

Query: 491 KTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVK 550
           K   + P     ++++ K  + EN  L+ ++A+LR E+  MK+ +  +E KYL++I+ V+
Sbjct: 474 KKMNSGPGTLSLSYKKEKDFLHENSTLQEEVAMLRLELDIMKHQSQLREKKYLEEIESVE 533

Query: 551 ETNAALEKYIKLNE 564
           + N  L K ++LNE
Sbjct: 534 KKNDNLLKALQLNE 547


>gi|239753333 PREDICTED: actin, beta-like 3 [Homo sapiens]
          Length = 924

 Score =  246 bits (627), Expect = 8e-65
 Identities = 185/554 (33%), Positives = 284/554 (51%), Gaps = 102/554 (18%)

Query: 19  DHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASG 78
           D  +    Y +   +L K+HRAA  G     +  +  R  D++  DKQ RTALHLA A+G
Sbjct: 88  DSAFMDPRYHVHGEDLDKLHRAAWWGKVPRKDLIVMLRDTDVNKRDKQKRTALHLASANG 147

Query: 79  HVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALH 138
           + +VV L+++R+CQ++V D + RT L +AV CQE+ CA++LLEHG +PN+ D YGNT LH
Sbjct: 148 NSEVVKLVLDRRCQLNVLDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLH 207

Query: 139 YAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKMVEFLLKRKASSHAVDRL 198
           YAVY+E   +A+ LL +GA IE+ +K   TPLL  I  +K+++V+FL+K+KA+ +A+DR 
Sbjct: 208 YAVYNEDKLMAKALLLYGADIESKNKHGLTPLLLGIHEQKQQVVKFLIKKKANLNALDRY 267

Query: 199 RRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKI 258
            R+AL+LAV   S  IV+ LL+QN+DV +QD  G+ A +YA+S H   I Q + ++K+K 
Sbjct: 268 GRTALILAVCCGSASIVSPLLEQNVDVSSQD-XGKTAREYAVSSHHHVICQLLSDYKEKQ 326

Query: 259 LKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCVPEKVSEPLPGSSHEKGN 318
           + K  S+  S+ E  + +  E     L  S++           PEK+S+           
Sbjct: 327 MLKISSE-NSNPEQDLKLTSEEESQRLKGSENSQ---------PEKMSQ----------E 366

Query: 319 RIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQERHERS 378
             +N  G+             E+ED                      +A EEE ++H   
Sbjct: 367 PEINKDGD------------RELED---------------------FMAIEEEMKKH--- 390

Query: 379 EKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGR----LTQQRKIGKTYPQQFPKKLK 434
                          S  +   EN+   T+ AAAG     L   RK      QQFP    
Sbjct: 391 --------------GSTHVGFPENL---TNGAAAGNGDDGLIPPRKSRTPESQQFPDTEN 433

Query: 435 EEH----DRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKS 490
           EE+       T KQ +EE+ N  +L     E L  +EKQ                +E+  
Sbjct: 434 EEYHSDEQNDTQKQLSEEQ-NTGIL---QDEILXHEEKQ----------------IEVAE 473

Query: 491 KTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVK 550
           K   + P     ++++ K  + EN  L+ ++A+LR E+  MK+ +  +E KYL++I+ V+
Sbjct: 474 KKMNSGPGTLSLSYKKEKDFLHENSTLQEEVAMLRLELDIMKHQSQLREKKYLEEIESVE 533

Query: 551 ETNAALEKYIKLNE 564
           + N  L K ++LNE
Sbjct: 534 KKNDNLLKALQLNE 547


>gi|239747898 PREDICTED: actin, beta-like 3 [Homo sapiens]
          Length = 924

 Score =  246 bits (627), Expect = 8e-65
 Identities = 185/554 (33%), Positives = 284/554 (51%), Gaps = 102/554 (18%)

Query: 19  DHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASG 78
           D  +    Y +   +L K+HRAA  G     +  +  R  D++  DKQ RTALHLA A+G
Sbjct: 88  DSAFMDPRYHVHGEDLDKLHRAAWWGKVPRKDLIVMLRDTDVNKRDKQKRTALHLASANG 147

Query: 79  HVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALH 138
           + +VV L+++R+CQ++V D + RT L +AV CQE+ CA++LLEHG +PN+ D YGNT LH
Sbjct: 148 NSEVVKLVLDRRCQLNVLDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLH 207

Query: 139 YAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKMVEFLLKRKASSHAVDRL 198
           YAVY+E   +A+ LL +GA IE+ +K   TPLL  I  +K+++V+FL+K+KA+ +A+DR 
Sbjct: 208 YAVYNEDKLMAKALLLYGADIESKNKHGLTPLLLGIHEQKQQVVKFLIKKKANLNALDRY 267

Query: 199 RRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKI 258
            R+AL+LAV   S  IV+ LL+QN+DV +QD  G+ A +YA+S H   I Q + ++K+K 
Sbjct: 268 GRTALILAVCCGSASIVSPLLEQNVDVSSQD-XGKTAREYAVSSHHHVICQLLSDYKEKQ 326

Query: 259 LKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCVPEKVSEPLPGSSHEKGN 318
           + K  S+  S+ E  + +  E     L  S++           PEK+S+           
Sbjct: 327 MLKISSE-NSNPEQDLKLTSEEESQRLKGSENSQ---------PEKMSQ----------E 366

Query: 319 RIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQERHERS 378
             +N  G+             E+ED                      +A EEE ++H   
Sbjct: 367 PEINKDGD------------RELED---------------------FMAIEEEMKKH--- 390

Query: 379 EKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGR----LTQQRKIGKTYPQQFPKKLK 434
                          S  +   EN+   T+ AAAG     L   RK      QQFP    
Sbjct: 391 --------------GSTHVGFPENL---TNGAAAGNGDDGLIPPRKSRTPESQQFPDTEN 433

Query: 435 EEH----DRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKS 490
           EE+       T KQ +EE+ N  +L     E L  +EKQ                +E+  
Sbjct: 434 EEYHSDEQNDTQKQLSEEQ-NTGIL---QDEILXHEEKQ----------------IEVAE 473

Query: 491 KTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVK 550
           K   + P     ++++ K  + EN  L+ ++A+LR E+  MK+ +  +E KYL++I+ V+
Sbjct: 474 KKMNSGPGTLSLSYKKEKDFLHENSTLQEEVAMLRLELDIMKHQSQLREKKYLEEIESVE 533

Query: 551 ETNAALEKYIKLNE 564
           + N  L K ++LNE
Sbjct: 534 KKNDNLLKALQLNE 547


>gi|53828703 POTE ankyrin domain family, member A isoform 2 [Homo
           sapiens]
          Length = 498

 Score =  240 bits (612), Expect = 4e-63
 Identities = 140/344 (40%), Positives = 210/344 (61%), Gaps = 20/344 (5%)

Query: 19  DHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASG 78
           D  +T   Y +R  +L K+HRAA  G+    +  +  R   ++  DK+ RTALHLACA+G
Sbjct: 51  DSAFTEPRYHVRREDLGKLHRAAWWGEVPRADLIVMLRGPGINKRDKKKRTALHLACANG 110

Query: 79  HVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALH 138
           + +VV+LL++R+CQ+ V D + RT LI+AV CQE+ CA++LL+HG +PNL D+YGNTALH
Sbjct: 111 NSEVVSLLLDRQCQLHVFDSKKRTALIKAVQCQEDECALMLLQHGTDPNLPDMYGNTALH 170

Query: 139 YAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKMVEFLLKRKASSHAVDRL 198
           YAVY+E   +A+ LL +GA IE+ +K   TPLL A+  +K++MV+FL+K+KA+ +A+DR 
Sbjct: 171 YAVYNEDKLMAKTLLLYGADIESKNKGGLTPLLLAVHGQKQRMVKFLIKKKANLNALDRF 230

Query: 199 RRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKI 258
            R+AL+LAV   S  IV++LL+QNIDVF+QD+ G+ AEDYA+S H + I Q + ++K+  
Sbjct: 231 GRTALILAVRCGSASIVSLLLQQNIDVFSQDVFGQTAEDYAVSSHHSIICQLLSDYKENQ 290

Query: 259 LKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVAT------KQCVPEKVSEPLPGS 312
           +    S   S+ E  + +  E     L  S++      T      K C  E   E     
Sbjct: 291 MPNNSSG-NSNPEQDLKLTSEEEPQRLKGSENSQHEKVTQEPDINKDCDREVEEEMQKHG 349

Query: 313 SHEKG------NRIVNGQGEG------PPAKHPSLK-PSTEVED 343
           S+  G      +    G G+G         KH + + P+TE+E+
Sbjct: 350 SNNVGLSENLTDGAAAGNGDGGLVPQRKSRKHENQQFPNTEIEE 393


>gi|52856434 POTE ankyrin domain family, member G [Homo sapiens]
          Length = 508

 Score =  231 bits (590), Expect = 2e-60
 Identities = 140/396 (35%), Positives = 230/396 (58%), Gaps = 26/396 (6%)

Query: 19  DHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASG 78
           D  +    Y +R  +L K+HRAA  G     +  +  +  D++  DKQ RTALHLA A+G
Sbjct: 125 DSAFMEPRYHVRREDLDKLHRAAWWGKVPRKDLIVMLKDTDMNKKDKQKRTALHLASANG 184

Query: 79  HVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALH 138
           + +VV LL++R+CQ+++ D + RT L +AV C+E+ CA++LLEHG +PN+ D YGNTALH
Sbjct: 185 NSEVVKLLLDRRCQLNILDNKKRTALTKAVQCREDECALMLLEHGTDPNIPDEYGNTALH 244

Query: 139 YAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKMVEFLLKRKASSHAVDRL 198
           YA+Y+E   +A+ LL +GA IE+ +K   TPLL  +  +K+++V+FL+K+KA+ +A+DR 
Sbjct: 245 YAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRY 304

Query: 199 RRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKI 258
            R+AL+LAV   S  IV++LL+QNIDV +QD+ G+ A +YA+S H   I Q + ++K+K 
Sbjct: 305 GRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHNVICQLLSDYKEKQ 364

Query: 259 LKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCVPEKVSEPLPGSSHEKGN 318
           + K  S+  S+ E  + +  E     L  S++           PE++S+      ++ G+
Sbjct: 365 MLKVSSE-NSNPEQDLKLTSEEESQRLKGSENSQ---------PEEMSQ--EPEINKGGD 412

Query: 319 RIVNGQGEGPPAKH---PSLKPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQERH 375
           R V  + +   + H   P   P+    D    G +  +  +T  ++Q     +E EQ   
Sbjct: 413 RKVEEEMKKHGSTHMGFPENLPNGATADNGDDGLIPPRKSRTPESQQF--PDTENEQYHS 470

Query: 376 ERSEKKQPQVKEGNNT---------NKSEKIQLSEN 402
           +     Q Q+ E  NT         ++ ++I+++EN
Sbjct: 471 DEQNDTQKQLSEEQNTGILQDEILIHEEKQIEVAEN 506


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.127    0.346 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,182,161
Number of Sequences: 37866
Number of extensions: 1365996
Number of successful extensions: 14497
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 506
Number of HSP's successfully gapped in prelim test: 1066
Number of HSP's that attempted gapping in prelim test: 6647
Number of HSP's gapped (non-prelim): 5047
length of query: 823
length of database: 18,247,518
effective HSP length: 111
effective length of query: 712
effective length of database: 14,044,392
effective search space: 9999607104
effective search space used: 9999607104
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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