Guide to the Human Genome
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Search of human proteins with 56790930

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|56790930 echinoderm microtubule associated protein like 1
isoform b [Homo sapiens]
         (815 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|56790930 echinoderm microtubule associated protein like 1 iso...  1671   0.0  
gi|56790932 echinoderm microtubule associated protein like 1 iso...  1660   0.0  
gi|6912356 echinoderm microtubule associated protein like 2 [Hom...   981   0.0  
gi|223029510 echinoderm microtubule associated protein like 4 is...   938   0.0  
gi|19923497 echinoderm microtubule associated protein like 4 iso...   920   0.0  
gi|110227615 echinoderm microtubule associated protein like 3 [H...   774   0.0  
gi|223005862 echinoderm microtubule associated protein like 6 [H...   394   e-109
gi|34485720 echinoderm microtubule associated protein like 5 [Ho...   382   e-106
gi|31377846 WD repeat domain 52 [Homo sapiens]                         85   2e-16
gi|94400919 WD repeat domain 90 [Homo sapiens]                         74   7e-13
gi|190684677 mitogen-activated protein kinase binding protein 1 ...    72   3e-12
gi|21071067 TBP-associated factor 5 [Homo sapiens]                     71   4e-12
gi|145580608 WD repeat domain 62 isoform 1 [Homo sapiens]              70   6e-12
gi|145580610 WD repeat domain 62 isoform 2 [Homo sapiens]              70   6e-12
gi|190684671 mitogen-activated protein kinase binding protein 1 ...    63   1e-09
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...    62   2e-09
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]          62   2e-09
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]          62   2e-09
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]          62   2e-09
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]            62   2e-09
gi|32189425 WD repeat domain 69 [Homo sapiens]                         61   5e-09
gi|124028512 WD40-repeat protein upregulated in HCC isoform b [H...    60   1e-08
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             57   9e-08
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             57   9e-08
gi|26665869 WD repeat domain 51B [Homo sapiens]                        56   1e-07
gi|145279222 WD repeat domain 66 [Homo sapiens]                        56   2e-07
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     54   6e-07
gi|16554629 WD repeat domain 5 [Homo sapiens]                          54   8e-07
gi|16554627 WD repeat domain 5 [Homo sapiens]                          54   8e-07
gi|48762926 PWP2 periodic tryptophan protein homolog [Homo sapiens]    54   8e-07

>gi|56790930 echinoderm microtubule associated protein like 1
           isoform b [Homo sapiens]
          Length = 815

 Score = 1671 bits (4328), Expect = 0.0
 Identities = 815/815 (100%), Positives = 815/815 (100%)

Query: 1   MEDGFSSYSSLYDTSSLLQFCNDDSASAASSMEVTDRIASLEQRVQMQEDDIQLLKSALA 60
           MEDGFSSYSSLYDTSSLLQFCNDDSASAASSMEVTDRIASLEQRVQMQEDDIQLLKSALA
Sbjct: 1   MEDGFSSYSSLYDTSSLLQFCNDDSASAASSMEVTDRIASLEQRVQMQEDDIQLLKSALA 60

Query: 61  DVVRRLNITEEQQAVLNRKGPTKARPLMQTLPLRTTVNNGTVLPKKPTGSLPSPSGVRKE 120
           DVVRRLNITEEQQAVLNRKGPTKARPLMQTLPLRTTVNNGTVLPKKPTGSLPSPSGVRKE
Sbjct: 61  DVVRRLNITEEQQAVLNRKGPTKARPLMQTLPLRTTVNNGTVLPKKPTGSLPSPSGVRKE 120

Query: 121 TAVPATKSNIKRTSSSERVSPGGRRESNGDSRGNRNRTGSTSSSSSGKKNSESKPKEPVF 180
           TAVPATKSNIKRTSSSERVSPGGRRESNGDSRGNRNRTGSTSSSSSGKKNSESKPKEPVF
Sbjct: 121 TAVPATKSNIKRTSSSERVSPGGRRESNGDSRGNRNRTGSTSSSSSGKKNSESKPKEPVF 180

Query: 181 SAEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKVELPTKRLKLEWVYGYRGRDCRNNLYL 240
           SAEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKVELPTKRLKLEWVYGYRGRDCRNNLYL
Sbjct: 181 SAEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKVELPTKRLKLEWVYGYRGRDCRNNLYL 240

Query: 241 LPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQ 300
           LPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQ
Sbjct: 241 LPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQ 300

Query: 301 LPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQK 360
           LPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQK
Sbjct: 301 LPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQK 360

Query: 361 EEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKF 420
           EEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKF
Sbjct: 361 EEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKF 420

Query: 421 VLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGK 480
           VLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGK
Sbjct: 421 VLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGK 480

Query: 481 DRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPITQ 540
           DRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPITQ
Sbjct: 481 DRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPITQ 540

Query: 541 GHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVA 600
           GHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVA
Sbjct: 541 GHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVA 600

Query: 601 VGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGR 660
           VGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGR
Sbjct: 601 VGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGR 660

Query: 661 KYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVETTRDIEWAT 720
           KYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVETTRDIEWAT
Sbjct: 661 KYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVETTRDIEWAT 720

Query: 721 YTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPSHIY 780
           YTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPSHIY
Sbjct: 721 YTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPSHIY 780

Query: 781 GGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI 815
           GGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI
Sbjct: 781 GGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI 815


>gi|56790932 echinoderm microtubule associated protein like 1
           isoform a [Homo sapiens]
          Length = 834

 Score = 1660 bits (4298), Expect = 0.0
 Identities = 815/834 (97%), Positives = 815/834 (97%), Gaps = 19/834 (2%)

Query: 1   MEDGFSSYSSLYDTSSLLQFCNDDSASAASSMEVTDRIASLEQRVQMQEDDIQLLKSALA 60
           MEDGFSSYSSLYDTSSLLQFCNDDSASAASSMEVTDRIASLEQRVQMQEDDIQLLKSALA
Sbjct: 1   MEDGFSSYSSLYDTSSLLQFCNDDSASAASSMEVTDRIASLEQRVQMQEDDIQLLKSALA 60

Query: 61  DVVRRLNITEEQQAVLNRKGPTKARPLMQTLPLRTTVNNGTVLPKKPTGSLPSPSGVRKE 120
           DVVRRLNITEEQQAVLNRKGPTKARPLMQTLPLRTTVNNGTVLPKKPTGSLPSPSGVRKE
Sbjct: 61  DVVRRLNITEEQQAVLNRKGPTKARPLMQTLPLRTTVNNGTVLPKKPTGSLPSPSGVRKE 120

Query: 121 TAVPATK-------------------SNIKRTSSSERVSPGGRRESNGDSRGNRNRTGST 161
           TAVPATK                   SNIKRTSSSERVSPGGRRESNGDSRGNRNRTGST
Sbjct: 121 TAVPATKRLNRSVSLLNACKLNRSTPSNIKRTSSSERVSPGGRRESNGDSRGNRNRTGST 180

Query: 162 SSSSSGKKNSESKPKEPVFSAEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKVELPTKRL 221
           SSSSSGKKNSESKPKEPVFSAEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKVELPTKRL
Sbjct: 181 SSSSSGKKNSESKPKEPVFSAEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKVELPTKRL 240

Query: 222 KLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVHP 281
           KLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVHP
Sbjct: 241 KLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVHP 300

Query: 282 DRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTN 341
           DRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTN
Sbjct: 301 DRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTN 360

Query: 342 LCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLE 401
           LCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLE
Sbjct: 361 LCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLE 420

Query: 402 GSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEG 461
           GSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEG
Sbjct: 421 GSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEG 480

Query: 462 GIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGT 521
           GIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGT
Sbjct: 481 GIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGT 540

Query: 522 TRNFVLQGTLSGDFTPITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDK 581
           TRNFVLQGTLSGDFTPITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDK
Sbjct: 541 TRNFVLQGTLSGDFTPITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDK 600

Query: 582 IIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFL 641
           IIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFL
Sbjct: 601 IIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFL 660

Query: 642 AIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVP 701
           AIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVP
Sbjct: 661 AIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVP 720

Query: 702 SACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFG 761
           SACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFG
Sbjct: 721 SACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFG 780

Query: 762 KVHLFSYPCSQFRAPSHIYGGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI 815
           KVHLFSYPCSQFRAPSHIYGGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI
Sbjct: 781 KVHLFSYPCSQFRAPSHIYGGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI 834


>gi|6912356 echinoderm microtubule associated protein like 2 [Homo
           sapiens]
          Length = 649

 Score =  981 bits (2537), Expect = 0.0
 Identities = 440/642 (68%), Positives = 534/642 (83%)

Query: 174 KPKEPVFSAEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKVELPTKRLKLEWVYGYRGRD 233
           K KE +FS E+G VKMFLRGRPV M +P +   +YSL+ + ELP+ RLKLEWVYGYRGRD
Sbjct: 8   KTKEVIFSVEDGSVKMFLRGRPVPMMIPDELAPTYSLDTRSELPSCRLKLEWVYGYRGRD 67

Query: 234 CRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVHPDRITIATGQVAG 293
           CR NLYLLPTGE VYF+ASV VLY+VEEQ QRHY GHNDD+KCLA+HPD +TIATGQVAG
Sbjct: 68  CRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAIHPDMVTIATGQVAG 127

Query: 294 TSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVL 353
           T+K+GK LPPHVRIWDSV+L+TLHV+G+G FDRAV C+ FSKSNGG  LCAVD+SNDH+L
Sbjct: 128 TTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGGNLLCAVDESNDHML 187

Query: 354 SVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFE 413
           SVWDW KE K+ DVKCSNEAV  A FHPTD  +++TCGKSH+YFWTLEG SL+K+QGLFE
Sbjct: 188 SVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLEGGSLSKRQGLFE 247

Query: 414 KQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGT 473
           K EKPK+VLCVTF E GD +TGDS GN+ VWGKG NRI+ AV GAH+GG+F LC LRDGT
Sbjct: 248 KHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVLGAHDGGVFGLCALRDGT 307

Query: 474 LVSGGGKDRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSG 533
           LVSGGG+DR+++ W  +Y KL++ E+PE FGP+RTVAEG GD + +GTTRN +LQG++  
Sbjct: 308 LVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHT 367

Query: 534 DFTPITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFH 593
            F+ + QGH +ELWGLA H S++QF+TCG DK   LW +  H+P+W +IIEDPA+S+GFH
Sbjct: 368 GFSLLVQGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWSRIIEDPARSAGFH 427

Query: 594 PSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIY 653
           PSGSV+AVGT+TGRW + DTET DLV +HTDGNEQ+SV+ +SPDG +LA+GSHDN +Y+Y
Sbjct: 428 PSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVY 487

Query: 654 GVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVETT 713
            V   GRK +R+GKCSGHSSFITHLDW+ +S   V+NSGDYEILYW P+ CKQ+ S +  
Sbjct: 488 TVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNSGDYEILYWDPATCKQITSADAV 547

Query: 714 RDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQF 773
           R++EWAT TC LGF VFG+W EG+DGTDINAV R+H+ KLL++ DDFGKVHLFSYPC Q 
Sbjct: 548 RNMEWATATCVLGFGVFGIWSEGADGTDINAVARSHDGKLLASADDFGKVHLFSYPCCQP 607

Query: 774 RAPSHIYGGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI 815
           RA SH YGGHSSHVTNV FL +DS  ++TGGKDTS++QWRV+
Sbjct: 608 RALSHKYGGHSSHVTNVAFLWDDSMALTTGGKDTSVLQWRVV 649


>gi|223029510 echinoderm microtubule associated protein like 4
           isoform b [Homo sapiens]
          Length = 923

 Score =  938 bits (2424), Expect = 0.0
 Identities = 445/806 (55%), Positives = 592/806 (73%), Gaps = 20/806 (2%)

Query: 23  DDSASAASSMEVTDRIASLEQRVQMQEDDIQLLKSALADVVRRLNITEEQQAVLNRKGPT 82
           DDS SAAS+ +V DR+++LE RVQ QED+I +LK+ALADV+RRL I+E+  A + +   +
Sbjct: 9   DDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSS 68

Query: 83  KARPLMQTLPLRTTVNNGTVLPKKPTGSLPSPSGVRKETAVPATKSNIKRTSSSERVSPG 142
           K +P  + +   + + NG+   +KP+ +  + S   KET   A KS IKR S +E+    
Sbjct: 69  KGQPSPRAVIPMSCITNGSGANRKPSHT-SAVSIAGKETLSSAAKS-IKRPSPAEKSHNS 126

Query: 143 GRRESNGDSRGNRNRTGSTSSSSSGKKNSESKPKEPVFSAEEGYVKMFLRGRPVTMYMPK 202
              E++ DSR   ++  ST         +  K K+ + + E  Y+KMF+RGRP+TM++P 
Sbjct: 127 W--ENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQEGEYIKMFMRGRPITMFIPS 184

Query: 203 DQVDSYSLEAKVELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQ 262
           D VD+Y  + + ELP ++LKLEW YGYRG+DCR N+YLLPTGE VYFIASVVVL+N EE+
Sbjct: 185 D-VDNYD-DIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGEIVYFIASVVVLFNYEER 242

Query: 263 LQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIG 322
            QRHY GH D VKCLA+HPD+I IATGQ+AG  KDG+ L PHVR+WDSVTL+TL +IG+G
Sbjct: 243 TQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLG 302

Query: 323 FFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPT 382
            F+R V C+ FSK++ G +LC +DDSN+H+L+VWDWQK+ K A++K +NE V A +FHPT
Sbjct: 303 TFERGVGCLDFSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPT 362

Query: 383 DTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNIL 442
           D N I+TCGKSH++FWT  G+SL +KQG+F K EKPKFV C+ F  NGD +TGDS G +L
Sbjct: 363 DANTIITCGKSHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVML 422

Query: 443 VWG------------KGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGN 490
           +W             KG  +IS  ++ AH+G +F LC +R+G L++GGGKDRK+I W  +
Sbjct: 423 IWSKTTVEPTPGKGPKGVYQISKQIK-AHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHD 481

Query: 491 YQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPITQGHTDELWGLA 550
               R+ E+P+Q+G IR VAEGK D  L+GT+RNF+L+GT +  F    QGHTDELWGLA
Sbjct: 482 LNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLA 541

Query: 551 IHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFV 610
            H  K   LTC  D+   LW+++ HR  W +++++P   + FHPSG+VVA+GT +GRWFV
Sbjct: 542 THPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFV 601

Query: 611 FDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSG 670
            D ET+DLV++HTDGNEQLSVMRYS DG FLA+GSHDN IY+Y VS+NGRKY+R G+C+G
Sbjct: 602 LDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTG 661

Query: 671 HSSFITHLDWSVNSQFLVSNSGDYEILYW-VPSACKQVVSVETTRDIEWATYTCTLGFHV 729
           HSS+ITHLDWS ++++++SNSGDYEILYW +P+ CK + +    +DI+W TYTC LGF V
Sbjct: 662 HSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQV 721

Query: 730 FGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPSHIYGGHSSHVTN 789
           FGVWPEGSDGTDINA+ R+H +K+++  DDF KVHLF YPCS+ +APSH Y  HSSHVTN
Sbjct: 722 FGVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTN 781

Query: 790 VDFLCEDSHLISTGGKDTSIMQWRVI 815
           V F   DSHLISTGGKD SI+QW+++
Sbjct: 782 VSFTHNDSHLISTGGKDMSIIQWKLV 807


>gi|19923497 echinoderm microtubule associated protein like 4
           isoform a [Homo sapiens]
          Length = 981

 Score =  920 bits (2379), Expect = 0.0
 Identities = 445/860 (51%), Positives = 590/860 (68%), Gaps = 70/860 (8%)

Query: 23  DDSASAASSMEVTDRIASLEQRVQMQEDDIQLLKSALADVVRRLNITEEQQAVLNRKGPT 82
           DDS SAAS+ +V DR+++LE RVQ QED+I +LK+ALADV+RRL I+E+  A + +   +
Sbjct: 9   DDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSS 68

Query: 83  KARPLMQTLPLRTTVNNGTVLPKKP------------TGSLPSPSGVRKETAVPATKSNI 130
           K +P  + +   + + NG+   +KP            T S  + SG  K+   P  +   
Sbjct: 69  KGQPSPRAVIPMSCITNGSGANRKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREK 128

Query: 131 KRTSSSERVSPGGRR------------------------------------------ESN 148
           K  S S   SP  R                                           E++
Sbjct: 129 KEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEKSHNSWENS 188

Query: 149 GDSRGNRNRTGSTSSSSSGKKNSESKPKEPVFSAEEGYVKMFLRGRPVTMYMPKDQVDSY 208
            DSR   ++  ST         +  K K+ + + E  Y+KMF+RGRP+TM++P D VD+Y
Sbjct: 189 DDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQEGEYIKMFMRGRPITMFIPSD-VDNY 247

Query: 209 SLEAKVELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYA 268
             + + ELP ++LKLEW YGYRG+DCR N+YLLPTGE VYFIASVVVL+N EE+ QRHY 
Sbjct: 248 D-DIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGEIVYFIASVVVLFNYEERTQRHYL 306

Query: 269 GHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAV 328
           GH D VKCLA+HPD+I IATGQ+AG  KDG+ L PHVR+WDSVTL+TL +IG+G F+R V
Sbjct: 307 GHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGV 366

Query: 329 TCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIV 388
            C+ FSK++ G +LC +DDSN+H+L+VWDWQK+ K A++K +NE V A +FHPTD N I+
Sbjct: 367 GCLDFSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTII 426

Query: 389 TCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWG--- 445
           TCGKSH++FWT  G+SL +KQG+F K EKPKFV C+ F  NGD +TGDS G +L+W    
Sbjct: 427 TCGKSHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTT 486

Query: 446 ---------KGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLRK 496
                    KG  +IS  ++ AH+G +F LC +R+G L++GGGKDRK+I W  +    R+
Sbjct: 487 VEPTPGKGPKGVYQISKQIK-AHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPERE 545

Query: 497 TEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPITQGHTDELWGLAIHASKS 556
            E+P+Q+G IR VAEGK D  L+GT+RNF+L+GT +  F    QGHTDELWGLA H  K 
Sbjct: 546 IEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKD 605

Query: 557 QFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETK 616
             LTC  D+   LW+++ HR  W +++++P   + FHPSG+VVA+GT +GRWFV D ET+
Sbjct: 606 LLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETR 665

Query: 617 DLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFIT 676
           DLV++HTDGNEQLSVMRYS DG FLA+GSHDN IY+Y VS+NGRKY+R G+C+GHSS+IT
Sbjct: 666 DLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYIT 725

Query: 677 HLDWSVNSQFLVSNSGDYEILYW-VPSACKQVVSVETTRDIEWATYTCTLGFHVFGVWPE 735
           HLDWS ++++++SNSGDYEILYW +P+ CK + +    +DI+W TYTC LGF VFGVWPE
Sbjct: 726 HLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPE 785

Query: 736 GSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPSHIYGGHSSHVTNVDFLCE 795
           GSDGTDINA+ R+H +K+++  DDF KVHLF YPCS+ +APSH Y  HSSHVTNV F   
Sbjct: 786 GSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHN 845

Query: 796 DSHLISTGGKDTSIMQWRVI 815
           DSHLISTGGKD SI+QW+++
Sbjct: 846 DSHLISTGGKDMSIIQWKLV 865


>gi|110227615 echinoderm microtubule associated protein like 3 [Homo
           sapiens]
          Length = 896

 Score =  774 bits (1999), Expect = 0.0
 Identities = 405/878 (46%), Positives = 543/878 (61%), Gaps = 95/878 (10%)

Query: 24  DSASAASSMEVTDRIASLEQRVQMQEDDIQLLKSALADVVRRLNITEEQQAV-------- 75
           D A+        + + SL QR+++QE +++L+K+ALA+ +R L +     ++        
Sbjct: 2   DGAAGPGDGPAREALQSLSQRLRVQEQEMELVKAALAEALRLLRLQVPPSSLQGSGTPAP 61

Query: 76  -------------------LNRKGPTKARPLMQTLPLRTTVNNGTVLPKKPTGSLPSPSG 116
                              ++R   T+    +++ P    ++NG   P  P G+   PSG
Sbjct: 62  PGDSLAAPPGLPPTCTPSLVSRGTQTETEVELKSSPGPPGLSNG---PPAPQGASEEPSG 118

Query: 117 VRKE--------TAVPATKSNIKRTSSSERVSPGGRRESNGDSRGNRNR----------- 157
            + E           P     ++     +R     R  S+  S   R R           
Sbjct: 119 TQSEGGGSSSSGAGSPGPPGILRPLQPPQRADTPRRNSSSSSSPSERPRQKLSRKAISSA 178

Query: 158 ---TGSTSSSSSGKKNSESKPKEPV-----FSAEEGYVKMFLRGRPVTMYMPKDQVDSYS 209
                S S+ S G K+  S P  P      ++ E   VKMFLRGRP+TMY+P        
Sbjct: 179 NLLVRSGSTESRGGKDPLSSPGGPGSRRSNYNLEGISVKMFLRGRPITMYIPS------G 232

Query: 210 LEAKVELPT----KRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQL-- 263
           + +  ELP+    + L L+WVYGYRGRD R+NL++L +GE VYFIA VVVLY        
Sbjct: 233 IRSLEELPSGPPPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGPGG 292

Query: 264 -----QRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHV 318
                QRHY GH D V+CLAVHPD + +A+GQ AG  KDGK L P V IWDS TL  L  
Sbjct: 293 PGGGGQRHYRGHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQE 352

Query: 319 IGIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAAD 378
           IG+G F+R V  +AFS ++ G  LC VDDSN+H+LSVWD  +  KLA++K +N++V A  
Sbjct: 353 IGLGAFERGVGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVG 412

Query: 379 FHPTDTNIIVTCGKSHLYFWTLEGS-------SLNKKQGLFEKQEKPKFVLCVTFSENGD 431
           F+P D++ IVT GKSH++FW   G        +L +KQG+F K +KPKF+ C  F  +GD
Sbjct: 413 FNPRDSSCIVTSGKSHVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVFLPDGD 472

Query: 432 TITGDSSGNILVWGK----------GTNRISYAVQG---AHEGGIFALCMLRDGTLVSGG 478
            +TGDS GNIL WG+          G  + +Y +     AHEG IFALC+ RDGT++SGG
Sbjct: 473 ILTGDSEGNILTWGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLRRDGTVLSGG 532

Query: 479 GKDRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPI 538
           G+DR+L+ W      L++ EIPE FG +R +AEG G  +L+GTT+N +L+G L+  F+P+
Sbjct: 533 GRDRRLVQWGPGLVALQEAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQGFSPV 592

Query: 539 TQGHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSV 598
            QGHTDELWGL  H S+++FLTCGHD+   LWD   H   W   +++    + FHPSG+V
Sbjct: 593 IQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPSGAV 652

Query: 599 VAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVSDN 658
           VAVG  TGRW V DTET+++V+   DGNEQLSV+RYSPDG +LAIGSHDN IYIY VS +
Sbjct: 653 VAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSD 712

Query: 659 GRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYW-VPSACKQVVSVETTRDIE 717
           G K +R G+C GHSSFITHLDWS +  F++SNSGDYEILYW V   CKQ+ +   +RD E
Sbjct: 713 GAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRYESRDRE 772

Query: 718 WATYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPS 777
           WATYTC LGFHV+GVWP+GSDGTDIN++CR+H +++++  DDF KVHLF YPC++ +APS
Sbjct: 773 WATYTCVLGFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPCARAKAPS 832

Query: 778 HIYGGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI 815
            +YGGH SHVT+V F  +DSHL+S GGKD SI QWRV+
Sbjct: 833 RMYGGHGSHVTSVRFTHDDSHLVSLGGKDASIFQWRVL 870


>gi|223005862 echinoderm microtubule associated protein like 6 [Homo
           sapiens]
          Length = 1958

 Score =  394 bits (1013), Expect = e-109
 Identities = 225/607 (37%), Positives = 342/607 (56%), Gaps = 27/607 (4%)

Query: 217 PTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKC 276
           P  +L+LEWVYGYRG  CRNNLY     E VYF+A V V+YN  E  Q+ + GHNDD+  
Sbjct: 7   PRCQLRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREHSQKFFLGHNDDIIS 66

Query: 277 LAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKS 336
           LA+HPD+  +ATGQV      GK+  P++ IWDS  + T+ ++        V C+AF   
Sbjct: 67  LALHPDKTLVATGQV------GKE--PYICIWDSYNVQTVSLLK-DVHTHGVACLAFDSD 117

Query: 337 NGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLY 396
             G  L +V     + + +WDW+K + LA     ++ +F   + P   N +V+CG  H+ 
Sbjct: 118 --GQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIK 175

Query: 397 FWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQ 456
           FWTL G++L  K+G+F K    + +LC+  ++   T +G  +G+I VW KG N +   +Q
Sbjct: 176 FWTLCGNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVW-KGLNLVR-TIQ 233

Query: 457 GAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQK-----LRKTEIPEQFGPIRTVAE 511
           GAH  GIF++    +G   + GG+D  +  W  +++      LR+TE   +   IR+V  
Sbjct: 234 GAHSAGIFSMYACEEG--FATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSVC- 290

Query: 512 GKGDVILIGTTRNFVLQGTLSGDFTP--ITQGHTD-ELWGLAIHASKSQFLTCGHDKHAT 568
            K D +L GT  + + +  +     P  I QGH + ELW LA+H  K   +T   D+   
Sbjct: 291 WKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVR 350

Query: 569 LWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQ 628
           LW    H  +    +E+  +S  F P GS +A+G   G + V        V    D  E 
Sbjct: 351 LWSLADHALIARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEV 410

Query: 629 LSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLV 688
           +  M++SPDG++LA+GS+D  + +Y V+   ++Y ++G+CS   SFITH+DWS++S++L 
Sbjct: 411 IHEMKFSPDGSYLAVGSNDGPVDVYAVA---QRYKKIGECSKSLSFITHIDWSLDSKYLQ 467

Query: 689 SNSGDYEILYWVPSACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRA 748
           +N G  E L++   + K + S E  + I WA++TC  G  V G+WP+ ++ TDIN+V   
Sbjct: 468 TNDGAGERLFYRMPSGKPLTSKEEIKGIPWASWTCVKGPEVSGIWPKYTEVTDINSVDAN 527

Query: 749 HEKKLLSTGDDFGKVHLFSYPCSQFRAPSHIYGGHSSHVTNVDFLCEDSHLISTGGKDTS 808
           +   +L +GDDFG V LF +PC +  A    Y GHS+HVTNV +  +   ++STGG D S
Sbjct: 528 YNSSVLVSGDDFGLVKLFKFPCLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLSTGGADHS 587

Query: 809 IMQWRVI 815
           + QWR I
Sbjct: 588 VFQWRFI 594



 Score =  354 bits (908), Expect = 2e-97
 Identities = 231/690 (33%), Positives = 347/690 (50%), Gaps = 46/690 (6%)

Query: 147  SNGDSRGNRNRTGSTSSSSSGKKNSESKPKEPVFSAEEGYV----KMFLRGRPVTMYMPK 202
            SNG         G+ S S     +    P+      +E  +    +++    P      K
Sbjct: 599  SNGMLETAPQEGGADSYSEESDSDLSDVPELDSDIEQEAQINYDRQVYKEDLPQLKQQSK 658

Query: 203  DQVDSYSLEAKVELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQ 262
            ++  +     + + P   LKL++++GYRG DCRNNL+    GE VY IA+V V+YN ++ 
Sbjct: 659  EKNHAVPFLKREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQH 718

Query: 263  LQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIG 322
             QR Y GH+DD+  L +HP +  +ATGQV      G+    HV  WD+ TL  L ++  G
Sbjct: 719  SQRLYLGHDDDILSLTIHPVKDYVATGQV------GRDAAIHV--WDTQTLKCLSLLK-G 769

Query: 323  FFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPT 382
               R V  + FS    G  L +V   + H +  WDW+K EK+A  +   + +F    +P 
Sbjct: 770  QHQRGVCALDFSAD--GKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPH 827

Query: 383  DTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTI-TGDSSGNI 441
              + +VT G  H+ FW   G     K+G F    K + ++CV++    D + +G ++G+I
Sbjct: 828  HVDKLVTVGIKHIKFWQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDI 887

Query: 442  LVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTE--- 498
             +W    + +      AH+G +FA+  L  G +   GGKD  +  W   +++  KT    
Sbjct: 888  FIW---KDILLLKTVKAHDGPVFAMYALDKGFVT--GGKDGIVELWDDMFERCLKTYAIK 942

Query: 499  -----------IPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPITQGHTD-EL 546
                       + E    IR +  G G  IL+GT    +L+   SG  T + QGH + E+
Sbjct: 943  RSALSTSSKGLLLEDNPSIRAITLGHGH-ILVGTKNGEILEIDKSGPMTLLVQGHMEGEV 1001

Query: 547  WGLAIHASKSQFLTCGHDKHATLWD-AVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLT 605
            WGLA H       T   DK   +W+ +  HR +  + ++   +   F P G  +AVG   
Sbjct: 1002 WGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLND 1061

Query: 606  GRWFVFDTET-KDLVTVHTDGNEQLSVMRYSPD-GNFLAIGSHDNCIYIYGVSDNGRKYT 663
            G + V + +T +D+V+ H    E +S +++S D G +LA+ SHDN + IY V  +     
Sbjct: 1062 GSFLVVNADTVEDMVSFH-HRKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTS----K 1116

Query: 664  RVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYW-VPSACKQVVSVETTRDIEWATYT 722
            RVG C G SS+ITH+DW    + L  NSG  E L++  P   + ++       IEW T+T
Sbjct: 1117 RVGICKGASSYITHIDWDSRGKLLQVNSGAREQLFFEAPRGKRHIIRPSEIEKIEWDTWT 1176

Query: 723  CTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPSHIYGG 782
            C LG    G+WP  SD TD+NA     +  LL+TGDDFG V LFSYP     A    Y G
Sbjct: 1177 CVLGPTCEGIWPAHSDITDVNAASLTKDCSLLATGDDFGFVKLFSYPVKGQHARFKKYVG 1236

Query: 783  HSSHVTNVDFLCEDSHLISTGGKDTSIMQW 812
            HS+HVTNV +L  DS L++ GG DT++M W
Sbjct: 1237 HSAHVTNVRWLHNDSVLLTVGGADTALMIW 1266



 Score =  321 bits (822), Expect = 2e-87
 Identities = 204/638 (31%), Positives = 320/638 (50%), Gaps = 33/638 (5%)

Query: 195  PVTMYMPKDQVDSYSLEAKVELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYF-IASV 253
            PV+   P+ +    +   K +   + L L+ V+GYRG DCRNNL+ L  G  + F  A+ 
Sbjct: 1337 PVSRAAPQPEKLQKNNITKKKKLVEELALDHVFGYRGFDCRNNLHYLNDGADIIFHTAAA 1396

Query: 254  VVLYNVEEQLQRHYAGHNDDVKCLAV--HPD-RITIATGQVAGTSKDGKQLPPHVRIWDS 310
             ++ N+    Q  Y  H DD+ CL V  HP  R  +AT Q+  T        P + IWD+
Sbjct: 1397 GIVQNLSTGSQSFYLEHTDDILCLTVNQHPKYRNVVATSQIGTT--------PSIHIWDA 1448

Query: 311  VTLNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCS 370
            +T +TL ++   F  + V  I FS +  G  L +V    +H ++VW WQ+  K+A     
Sbjct: 1449 MTKHTLSMLRC-FHSKGVNYINFSAT--GKLLVSVGVDPEHTITVWRWQEGAKVASRGGH 1505

Query: 371  NEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEK--QEKPKFVLCVTFSE 428
             E +F  +F P      V+ G  H+ FWTL GS+L  K+G+       K + +L V F  
Sbjct: 1506 LERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYKKGVIGSLGAAKMQTMLSVAFGA 1565

Query: 429  NGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFAL-CMLRDGTLVSGGGKDRKLIS- 486
            N  T TG  +G++ VW    + +   V  AH G +F +   LRDG +V+GG K+R     
Sbjct: 1566 NNLTFTGAINGDVYVWKD--HFLIRLVAKAHTGPVFTMYTTLRDGLIVTGG-KERPTKEG 1622

Query: 487  -----WSGNYQKLR--KTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQ-GTLSGDFTPI 538
                 W    ++ R  + E  +    +R+V  GKG  IL+GT    +++ G  +     +
Sbjct: 1623 GAVKLWDQEMKRCRAFQLETGQLVECVRSVCRGKGK-ILVGTKDGEIIEVGEKNAASNIL 1681

Query: 539  TQGHTD-ELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGS 597
              GH + E+WGLA H SK  F++  +D  A +WD    + +    +   A+ + + P G 
Sbjct: 1682 IDGHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHAARCAAYSPDGE 1741

Query: 598  VVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVSD 657
            +VA+G   G + +    +  +     D    +  +R SPD  FLA+GS ++ +  Y ++ 
Sbjct: 1742 MVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQ 1801

Query: 658  NGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVETTRDIE 717
             G    R+G C    SF+  +D+S + +++  ++G Y+         KQV        I 
Sbjct: 1802 -GTNLNRIGYCKDIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVPLGKQVTEAVVIEKIT 1860

Query: 718  WATYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPS 777
            WA++T  LG  V G+WP  +D  D+N  C  H    + TGDDFG V LF +PC++  A  
Sbjct: 1861 WASWTSVLGDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDFPCTEKFAKH 1920

Query: 778  HIYGGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI 815
              Y GHS+HVTN+ F  +D +++STGG D S+  WR +
Sbjct: 1921 KRYFGHSAHVTNIRFSYDDKYVVSTGGDDCSVFVWRCL 1958


>gi|34485720 echinoderm microtubule associated protein like 5 [Homo
           sapiens]
          Length = 1977

 Score =  382 bits (982), Expect = e-106
 Identities = 220/607 (36%), Positives = 343/607 (56%), Gaps = 27/607 (4%)

Query: 217 PTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKC 276
           P+  L+LEWVYGYRG  CRNNLY     E VYF+A V V+Y+  E  Q+ Y GH+DD+  
Sbjct: 7   PSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGHSDDIIS 66

Query: 277 LAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKS 336
           LA+HP+R+ +ATGQV      GK+  P++ IWDS T+ T+ V+        + C+AF   
Sbjct: 67  LALHPERVLVATGQV------GKE--PYICIWDSYTVQTISVLK-DVHTHGIACLAFDLD 117

Query: 337 NGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLY 396
             G  L +V   + + + VWDW++ + L+      + +F   +     N +V+CG  H+ 
Sbjct: 118 --GQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIK 175

Query: 397 FWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQ 456
           FW+L G++L  K+G+F K    + +LC+  + +  T +G  +G+I VW KG N I   +Q
Sbjct: 176 FWSLCGNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVW-KGINLIR-TIQ 233

Query: 457 GAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQK-----LRKTEIPEQFGPIRTVAE 511
           GAH  GIF++    +G   + GG+D  +  W   ++      LR+T+   +   +R+V  
Sbjct: 234 GAHAAGIFSMNACEEG--FATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVC- 290

Query: 512 GKGDVILIGTTRNFVLQGTLSGDFTP--ITQGHTD-ELWGLAIHASKSQFLTCGHDKHAT 568
            +GD IL+GT  + + +  +     P  I QGH + ELW LA+H +K   +T   D+   
Sbjct: 291 WRGDHILVGTQDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVR 350

Query: 569 LWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQ 628
           +W  V H  +    +E+P + +  +  G  +A+G   G + V        V    D  E 
Sbjct: 351 IWSLVDHALIARCNMEEPIRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEA 410

Query: 629 LSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLV 688
           +  ++YSPDG +LA+G +D+ + IYGV+   ++Y +VG+C G  SFITHLDWS +S++L 
Sbjct: 411 IHELKYSPDGTYLAVGCNDSSVDIYGVA---QRYKKVGECLGSLSFITHLDWSSDSRYLQ 467

Query: 689 SNSGDYEILYWVPSACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRA 748
           +N G+ + L++     K+V S E  + + WA++TC  G  V G+WP+ SD  DIN+V   
Sbjct: 468 TNDGNGKRLFYRMPGGKEVTSTEEIKGVHWASWTCVSGLEVNGIWPKYSDINDINSVDGN 527

Query: 749 HEKKLLSTGDDFGKVHLFSYPCSQFRAPSHIYGGHSSHVTNVDFLCEDSHLISTGGKDTS 808
           +  ++L T DD+G + LF YPC +  A    Y GHS+HVTNV +  +   +IS GG D S
Sbjct: 528 YIGQVLVTADDYGIIKLFRYPCLRKGAKFRKYIGHSAHVTNVRWSHDYQWVISIGGADHS 587

Query: 809 IMQWRVI 815
           + QW+ I
Sbjct: 588 VFQWKFI 594



 Score =  341 bits (874), Expect = 2e-93
 Identities = 222/660 (33%), Positives = 337/660 (51%), Gaps = 34/660 (5%)

Query: 176  KEPVFSAEEGYVKMFLRGR--PVTMYMPKDQVDSYSLEAKVELPTKRLKLEWVYGYRGRD 233
            KEP     +G V    RG   PV+   P+ +    +   K + P + L LE ++GYRGRD
Sbjct: 1328 KEPSIDERQGVV----RGSRPPVSRAPPQPEKLQTNNVGKKKRPIEDLVLELIFGYRGRD 1383

Query: 234  CRNNLYLLPTGETV-YFIASVVVLYNVEEQLQRHYAGHNDDVKCLAV--HPDRITI-ATG 289
            CRNN++ L  G+ + Y  ASV +L+NV    Q  Y  HNDD+ CL V  HP  I I ATG
Sbjct: 1384 CRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTVNQHPKFINIVATG 1443

Query: 290  QVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSN 349
            QV G S D     P + IWD++   TL ++   +  + V  ++FS +  G  L +V    
Sbjct: 1444 QV-GDSADMSATAPSIHIWDAMNKQTLSILRC-YHSKGVCSVSFSAT--GKLLLSVGLDP 1499

Query: 350  DHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKKQ 409
            +H +++W WQ+  K+A     N+ +F A+F P      V+ G  H+ FWTL G +L  K+
Sbjct: 1500 EHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTLAGRALLSKK 1559

Query: 410  GLFEKQEKPKF--VLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFAL- 466
            GL    E  +   +L + F  N  T TG  SG++ VW    + +   V  AH G +FA+ 
Sbjct: 1560 GLLSTLEDARMQTMLAIAFGANNLTFTGTISGDVCVWKD--HILCRIVARAHNGPVFAMY 1617

Query: 467  CMLRDGTLVSGGGKDRK------LISWSGNYQKLR--KTEIPEQFGPIRTVAEGKGDVIL 518
              LRDG +V+GG K+R       +  W    ++ R  + E  +    +R+V  GKG  IL
Sbjct: 1618 TTLRDGLIVTGG-KERPSKEGGAVKLWDQELRRCRAFRLETGQATDCVRSVCRGKGK-IL 1675

Query: 519  IGTTRNFVLQ-GTLSGDFTPITQGHTD-ELWGLAIHASKSQFLTCGHDKHATLWDAVGHR 576
            +GT    +++ G  +     +  GH D  +WGLA H S+  FL+   D    LWD    +
Sbjct: 1676 VGTRNAEIIEVGEKNAACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKK 1735

Query: 577  PVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSP 636
             +    +   A++  + P G +VA+G   G + +    +  +     D    +  +R+SP
Sbjct: 1736 MLNKVNLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSP 1795

Query: 637  DGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEI 696
            D  +LA+GS +N +  Y ++  G    R+  C    SF+  +D+S +S +L  +SG Y+ 
Sbjct: 1796 DSRYLAVGSSENSVDFYDLT-LGPTLNRISYCKDIPSFVIQMDFSADSSYLQVSSGCYKR 1854

Query: 697  -LYWVPSACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLS 755
             +Y VPS  K ++       I WAT+T  LG  V G+W   ++  D+N  C +H    L 
Sbjct: 1855 HVYEVPSG-KHLMDHAAIDRITWATWTSILGDEVLGIWSRHAEKADVNCACVSHSGISLV 1913

Query: 756  TGDDFGKVHLFSYPCSQFRAPSHIYGGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI 815
            TGDDFG V LF +PC +  A    + GHS HVTN+ F   D H++S GG D S+  W+ +
Sbjct: 1914 TGDDFGMVKLFDFPCPEKFAKHKRFLGHSPHVTNIRFTSGDRHVVSAGGDDCSLFVWKCV 1973



 Score =  335 bits (859), Expect = 1e-91
 Identities = 207/633 (32%), Positives = 326/633 (51%), Gaps = 46/633 (7%)

Query: 202  KDQVDSYSLEAKVELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEE 261
            K++  S + + +   P   ++L +V+GYRG DCR+NL+    GE VY +A+V V+YN ++
Sbjct: 658  KEKQKSATSKRRERAPGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQ 717

Query: 262  QLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGI 321
              QR Y GH+DD+ CL +HP +  +ATGQV           P + IWD+ T+  L ++  
Sbjct: 718  NTQRFYLGHDDDILCLTIHPLKDYVATGQVG--------RDPSIHIWDTETIKPLSILK- 768

Query: 322  GFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHP 381
            G     V+ + FS    G  L +V   + H + +WDW+K EKL+  + S + +F    +P
Sbjct: 769  GHHQYGVSAVDFSAD--GKRLASVGIDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMNP 826

Query: 382  TDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGD-TITGDSSGN 440
               + ++T G  H+ FW   G  L  ++G      K   ++C  +    +   +G S+G+
Sbjct: 827  YVPDKLITAGIKHMKFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGD 886

Query: 441  ILVWGKGTNRISYAVQ--GAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTE 498
            + +W     R  + V+   AH+G +F++  L  G +   GGKD  +  W  ++++  KT 
Sbjct: 887  VCIW-----RDIFLVKTVKAHDGPVFSMHALEKGFVT--GGKDGIVALWDDSFERCLKTY 939

Query: 499  --------------IPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPITQGHTD 544
                          + E    IR ++ G G  IL+GT    +L+   SG  T + QGH +
Sbjct: 940  AIKRAALAPGSKGLLLEDNPSIRAISLGHGH-ILVGTKNGEILEVDKSGPITLLVQGHME 998

Query: 545  -ELWGLAIHASKSQFLTCGHDKHATLWD-AVGHRPVWDKIIEDPAQSSGFHPSGSVVAVG 602
             E+WGLA H       T   DK   +WD +  H  +  + ++   +   F P G  +AVG
Sbjct: 999  GEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVG 1058

Query: 603  TLTGRWFVFDTET-KDLVTVHTDGNEQLSVMRYSP-DGNFLAIGSHDNCIYIYGVSDNGR 660
               G + + + +T +DLV+ H    + +S +R+SP  G +LA+ SHD+ I IY V  +  
Sbjct: 1059 LNDGSFLMANADTLEDLVSFH-HRKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSS-- 1115

Query: 661  KYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYW-VPSACKQVVSVETTRDIEWA 719
               RVG C G +S+ITH+DW +  + L  N+G  E L++  P   KQ +       I WA
Sbjct: 1116 --KRVGICKGATSYITHIDWDIRGKLLQVNTGAKEQLFFEAPRGKKQTIPSVEVEKIAWA 1173

Query: 720  TYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPSHI 779
            ++T  LG    G+WP   + TD+ A C   +K +L+TGDD G V LF YP          
Sbjct: 1174 SWTSVLGLCCEGIWPVIGEVTDVTASCLTSDKMVLATGDDLGFVKLFRYPTKGKFGKFKR 1233

Query: 780  YGGHSSHVTNVDFLCEDSHLISTGGKDTSIMQW 812
            Y  HS+HVTNV +  +DS L++ GG D S+M W
Sbjct: 1234 YVAHSTHVTNVRWTYDDSMLVTLGGTDMSLMVW 1266


>gi|31377846 WD repeat domain 52 [Homo sapiens]
          Length = 982

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 124/609 (20%), Positives = 229/609 (37%), Gaps = 85/609 (13%)

Query: 118 RKETAVPATKSNIKRTSSSERVSPGGRRESNGDSRGNRNRTGSTSSSSSGKKNSESKPKE 177
           + E+  P  + N      ++     G      +        GS SS   G   S + P++
Sbjct: 29  KSESRSPVQEDNTFLEDDTDETFTKGEGSYLEEDSDEERLEGSLSSFQYGDLQSTTVPQQ 88

Query: 178 ---PVFSAEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKVELPTKRLKLEWVYGYRGRDC 234
              P     E  VK  +       YM    +   +L++ +  P   L L   +GY   DC
Sbjct: 89  TPAPAVEEAEEEVKKKISESFFYDYMELASMPFVTLDSNI--PLDLLTLVHSFGY---DC 143

Query: 235 RN--NLYLLPTGETVYFIASVVVLYNVEEQLQRHY-AGHNDDVKCLAVHPDRITIATGQV 291
           R   NL LL     +Y   + ++  N++ + Q +  +   + +  + VHP +      + 
Sbjct: 144 RKRANLQLLDDSIAIYIAGNQLIFLNLKTKEQIYLRSSSGEGIGVIGVHPHKTYFTVAE- 202

Query: 292 AGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDH 351
                  K   P + I++  +L    V+  G  ++    + F+ S  G  L +V  + D+
Sbjct: 203 -------KGSFPDIIIYEYPSLRPYRVLRDGT-EKGYAYVDFNYS--GNLLASVGSNPDY 252

Query: 352 VLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFW----TLEGSSLNK 407
            L++W+W++E+ +   K  ++ VF   F+P     + T G  H+ FW    T  G  L  
Sbjct: 253 TLTIWNWKEEQPILRTKAFSQEVFKVTFNPDKEEQLTTSGSGHIKFWEMAFTFTGLKLQG 312

Query: 408 KQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRISY---AVQGAHEGGIF 464
             G F K         +   + G  ++G   GN+L+W  G  ++       +  H G I 
Sbjct: 313 SLGRFGKTITTDIEGYMELPD-GKVLSGSEWGNMLLWEGGLIKVELCRGTSKSCHNGPIN 371

Query: 465 ALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTEIPEQFG-----PIRTVAEGK-----G 514
            + ML +G +++  G D  +  W  +++ +   ++ ++ G     PI  +   K      
Sbjct: 372 QI-MLYEGEVIT-VGSDGYVRIW--DFETIDTADVIDETGLLEIEPINELQVDKNVNLFS 427

Query: 515 DVILIGTTRNFVLQGTLSG-------DFTPITQG-------HTDELWGLAIHASKSQFLT 560
            + +  T  NF L    +G        F+ ITQ        H+  +  +A+        T
Sbjct: 428 MIKMNETGNNFWLAQDANGAIWKLDLSFSNITQDPECLFSFHSGAIEAVAVSPLTYLMAT 487

Query: 561 CGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHP-----SGSVVAVG------------- 602
              D    ++D     P+     +    +  + P     +G+ + VG             
Sbjct: 488 TALDCSVRIYDFASKTPLAQMKFKQGGTALVWVPRMVNFTGAQIIVGFEDGVVRILELYD 547

Query: 603 -----TLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVSD 657
                   GR  + D + + L  V       ++ + Y  DG  LA GS D  ++ + V  
Sbjct: 548 PKGLTIFAGRKKILDADIQ-LKQVFKPHTACVTALAYERDGEILATGSKDQTVFFFEVE- 605

Query: 658 NGRKYTRVG 666
             R Y  +G
Sbjct: 606 --RDYKPIG 612


>gi|94400919 WD repeat domain 90 [Homo sapiens]
          Length = 1748

 Score = 73.6 bits (179), Expect = 7e-13
 Identities = 101/481 (20%), Positives = 169/481 (35%), Gaps = 58/481 (12%)

Query: 216 LPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVK 275
           LP   L+L+ V G+ G   R  L+       VY   +V+V+  V+   QR + GH D V 
Sbjct: 354 LPDPVLRLKGVIGFGGHGTRQALWTPDGAAVVYPCHAVIVVLLVDTGEQRFFLGHTDKVS 413

Query: 276 CLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSK 335
            LA+      +A+ Q         + P  +R+WD  T   L +    F        + S 
Sbjct: 414 ALALDGSSSLLASAQA--------RAPSVMRLWDFQTGRCLCL----FRSPMHVVCSLSF 461

Query: 336 SNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPT-----------DT 384
           S+ G  LC V   +     V  W        V    E V  A  H             D 
Sbjct: 462 SDSGALLCGVGKDHHGRTMVVAW----GTGQVGLGGEVVVLAKAHTDFDVQAFRVTFFDE 517

Query: 385 NIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVW 444
             + +CG+  +  W L G  L        +    +F   + F +  D     S+  + V 
Sbjct: 518 TRMASCGQGSVRLWRLRGGVLRSCPVDLGEHHALQFT-DLAFKQARDGCPEPSAAMLFVC 576

Query: 445 GKGTNRISYAVQ-----------------GAHE--------GGIFALCMLRDGTLVSGGG 479
            +  + +    Q                 G H          GI    +     + + G 
Sbjct: 577 SRSGHILEIDCQRMVVRHARRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPAMCAVGS 636

Query: 480 KDRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVL--QGTLSGDFTP 537
           +D  L  W  ++  +      E  GP+ +V      + ++  T +  L    TLS  +  
Sbjct: 637 EDGFLRLWPLDFSSVLLE--AEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHM 694

Query: 538 ITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWD-KIIEDPAQSSGFHPSG 596
           + + HT  +  LA+   + Q  T   D+   +WD    + ++D    ED   +  FHP+ 
Sbjct: 695 LARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTR 754

Query: 597 SVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVS 656
                G  +G    F  E  +++  HT     ++ +  +PDG  L        +  Y  +
Sbjct: 755 PTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLAQYSCA 814

Query: 657 D 657
           D
Sbjct: 815 D 815



 Score = 73.2 bits (178), Expect = 9e-13
 Identities = 78/369 (21%), Positives = 146/369 (39%), Gaps = 33/369 (8%)

Query: 221  LKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVH 280
            L+L+ V GY G    N ++   TG   Y    +VV+ ++    Q+H++GH+ ++  LA+ 
Sbjct: 1108 LRLKAVVGYSGNGRANMVWRPDTGFFAYTCGRLVVVEDLHSGAQQHWSGHSAEISTLALS 1167

Query: 281  PDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGT 340
                 +A    + + +        +R+WD       H+I    F  + T +A + S    
Sbjct: 1168 HSAQVLA----SASGRSSTTAHCQIRVWDVSGGLCQHLI----FPHSTTVLALAFSPDDR 1219

Query: 341  NLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTL 400
             L  + D +   L++W     + ++  +   E V    F+P D   +   G+  + FW L
Sbjct: 1220 LLVTLGDHDGRTLALWGTATYDLVSSTRLP-EPVHGVAFNPWDAGELTCVGQGTVTFWLL 1278

Query: 401  E--GSSLNKKQGLFEKQEKPKFV-----LCVTFSENGDTITGDSSGNILVWGKGTNRISY 453
            +  G+ ++ +     ++  P+ V       + +        G SSG + VW     R   
Sbjct: 1279 QQRGADISLQ---VRREPVPEAVGAGELTSLCYGAPPLLYCGTSSGQVCVWDTRAGRCFL 1335

Query: 454  AVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLR-----------KTEIPEQ 502
            + + A +GGI  L +     LVSG    R  +   G   +LR           + E+   
Sbjct: 1336 SWE-ADDGGI-GLLLFSGSRLVSGSSTGRLRLWAVGAVSELRCKGSGASSVFMEHELVLD 1393

Query: 503  FGPIRTVAEGKGDVILIGTTRNFV-LQGTLSGDFTPITQGHTDELWGLAIHASKSQFLTC 561
               +    +   D+ ++GTT   +       G  T +  GH  ++  +     +S   TC
Sbjct: 1394 GAVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSKVNEVVFSPGESHCATC 1453

Query: 562  GHDKHATLW 570
              D    +W
Sbjct: 1454 SEDGSVRVW 1462


>gi|190684677 mitogen-activated protein kinase binding protein 1
           isoform b [Homo sapiens]
          Length = 1514

 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 180/761 (23%), Positives = 269/761 (35%), Gaps = 173/761 (22%)

Query: 187 VKMFLRGRPVTMYMPKDQVDSYSLEAKVELPTKRLKLEWVYGYRGRDC--RNNLYLLPTG 244
           +K  LR   + +   K       L +KV L  K L +  V G RG  C  R+ L   P G
Sbjct: 12  IKNLLRSPSIKLRRSKAGNRREDLSSKVTLE-KVLGIT-VSGGRGLACDPRSGLVAYPAG 69

Query: 245 ETVYFIASVVVLYNVEEQLQRHYAGHN-DDVKCLAVHPDRITIATGQVAGTSKDGKQLPP 303
                   VVVL+N  +  Q H    +   +  LA  PD   + TG+            P
Sbjct: 70  -------CVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHM--------P 114

Query: 304 HVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEK 363
            VR+WD    +   V  +      V C+AFS S     + +V   +D +++VW W+K   
Sbjct: 115 AVRVWDVAEHS--QVAELQEHKYGVACVAFSPS--AKYIVSVGYQHDMIVNVWAWKKNIV 170

Query: 364 LADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNK---------KQGLFEK 414
           +A  K S+  V A  F   D +  VT G  H+ FW L+ S  +K         + GL  +
Sbjct: 171 VASNKVSSR-VTAVSFSE-DCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGE 228

Query: 415 QEKPKF--VLCVTFSENGDTITGDSSGNIL---------VWGKGTNRISYAVQGAHEGGI 463
                F  V C    +   T    SSG +           W +  N  S+    AH   +
Sbjct: 229 LRNNLFTDVACGRGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHCISV 288

Query: 464 ---FALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTEIPEQFG-PIRTVAEGKGDVILI 519
              +  C   DGT+        +L + S N   L     P   G  I +V E      L 
Sbjct: 289 SQDYIFCGCADGTV--------RLFNPS-NLHFLSTLPRPHALGTDIASVTEASR---LF 336

Query: 520 GTTRNFVLQGTLSGDFTPITQG-----------------------------HTDELWGLA 550
               N     T++  F P  Q                              H+  +W + 
Sbjct: 337 SGVANARYPDTIALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVE 396

Query: 551 IHAS----------KSQFLTCGHDKHATLWDAVG--------HRPVWD----KII----- 583
           ++             S F+TC  D    LW+           HR +      KII     
Sbjct: 397 VYPEVKDSNQACLPPSSFITCSSDNTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGN 456

Query: 584 -----------EDPAQSSGFHP-----------SGSVVAVGTLTGRWFVFDTET-KDLVT 620
                       D A +S   P           +G  +A G   G   V + ++  +++ 
Sbjct: 457 TQALLDTELPGGDKADASLLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLK 516

Query: 621 VHTDGNEQLSVMRYSPDG--NFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHL 678
           V    +E L +    PD     LA  S D  I+   V D GR+Y+       HSS IT +
Sbjct: 517 VEAHDSEILCLEYSKPDTGLKLLASASRDRLIH---VLDAGREYSLQQTLDEHSSSITAV 573

Query: 679 DWSV-NSQFLVSNSGDYEILYWVPSACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGS 737
            ++  + Q  + + G  + +Y+  +A K    V+ TR       T      V   W   +
Sbjct: 574 KFAASDGQVRMISCGADKSIYF-RTAQKSGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTA 632

Query: 738 DGTD-----INAVCRAHEKKLL--STGDDFGKVHLFSYPCSQFRAPS------HIYG--- 781
            G       I  +    +KKL   S G+D   + + + P   + A S       I+    
Sbjct: 633 IGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSS 692

Query: 782 --------GHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRV 814
                   GHS  VT + F  +  HLIS  G D+ I  WR+
Sbjct: 693 GECVATMFGHSEIVTGMKFSNDCKHLISVSG-DSCIFVWRL 732



 Score = 30.8 bits (68), Expect = 5.3
 Identities = 17/63 (26%), Positives = 31/63 (49%)

Query: 594 PSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIY 653
           PSG  +A         +FD  + + V      +E ++ M++S D   L   S D+CI+++
Sbjct: 671 PSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 730

Query: 654 GVS 656
            +S
Sbjct: 731 RLS 733


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 69/288 (23%), Positives = 122/288 (42%), Gaps = 47/288 (16%)

Query: 462 GIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKT--------------EIPEQFGPIR 507
           G+ A+ +  D +L++GG  D  +  WS   +KLR                ++ E+    +
Sbjct: 472 GLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEK 531

Query: 508 TVAEGKGDVILIGTT-----------RNFVLQGTLSGD--------FTPIT--QGHTDEL 546
           T +E K   IL G +           RN++L  +  G         FT +   +GH   +
Sbjct: 532 TASELK---ILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPV 588

Query: 547 WGLAIHASKSQFLTCGHDKHATLWDAVGHRP--VWDKIIEDPAQSSGFHPSGSVVAVGTL 604
           W          F++ GHD+ A LW    ++P  ++   + D    + FHP+ + VA G+ 
Sbjct: 589 WDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLAD-VNCTRFHPNSNYVATGSA 647

Query: 605 TGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTR 664
                ++D    + V + T     +  + +SP+G FLA G+ D  + ++ +         
Sbjct: 648 DRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHG----LM 703

Query: 665 VGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVET 712
           VG+  GH+  +  L +S + + L S S D  +  W   A K    +ET
Sbjct: 704 VGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW--DAIKAFEDLET 749



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 55/228 (24%), Positives = 88/228 (38%), Gaps = 39/228 (17%)

Query: 269 GHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAV 328
           GH+  V   +  PDR       +  +S+DG      VR+W   T   L  +G    +  V
Sbjct: 541 GHSGPVYGASFSPDR-----NYLLSSSEDGT-----VRLWSLQTFTCL--VGYKGHNYPV 588

Query: 329 TCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKL-------ADVKCSNEAVFAADFHP 381
               FS          V   +D V  +W     + L       ADV C+        FHP
Sbjct: 589 WDTQFSPYG----YYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTR-------FHP 637

Query: 382 TDTNIIVTCGKSHLYFW-TLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTI-TGDSSG 439
               +        +  W  L G+ +     +F   + P  +  +TFS NG  + TG + G
Sbjct: 638 NSNYVATGSADRTVRLWDVLNGNCVR----IFTGHKGP--IHSLTFSPNGRFLATGATDG 691

Query: 440 NILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISW 487
            +L+W  G   +   ++G H   + +L   RDG +++ G  D  +  W
Sbjct: 692 RVLLWDIGHGLMVGELKG-HTDTVCSLRFSRDGEILASGSMDNTVRLW 738



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 18/54 (33%), Positives = 25/54 (46%), Gaps = 10/54 (18%)

Query: 265 RHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHV 318
           R +AGH  DV C   HP+   +ATG    T          VR+WD +  N + +
Sbjct: 621 RIFAGHLADVNCTRFHPNSNYVATGSADRT----------VRLWDVLNGNCVRI 664


>gi|145580608 WD repeat domain 62 isoform 1 [Homo sapiens]
          Length = 1523

 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 62/198 (31%), Positives = 93/198 (46%), Gaps = 17/198 (8%)

Query: 212 AKVELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRH-YAGH 270
           A  E    R+ LE V G   ++         TG   Y    VVV+ + +E  Q+H +   
Sbjct: 51  ASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTA 110

Query: 271 NDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTL-HVIGIGFFDRAVT 329
              +  LA  PD   I TG+      +G +  P VRIWD    N +  ++G  +    V 
Sbjct: 111 RKSLSALAFSPDGKYIVTGE------NGHR--PAVRIWDVEEKNQVAEMLGHKY---GVA 159

Query: 330 CIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVT 389
           C+AFS +    ++ ++   +D VL+VWDW+K+  +A  K S   V A  F   D++  VT
Sbjct: 160 CVAFSPNM--KHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCR-VIALSF-SEDSSYFVT 215

Query: 390 CGKSHLYFWTLEGSSLNK 407
            G  H+ FW LE S+  K
Sbjct: 216 VGNRHVRFWFLEVSTETK 233



 Score = 32.0 bits (71), Expect = 2.4
 Identities = 21/78 (26%), Positives = 33/78 (42%), Gaps = 5/78 (6%)

Query: 623 TDGNE-QLSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWS 681
           + G+E  L  +   P G FLA    D  I +            + K  GHS  IT + ++
Sbjct: 669 SQGDEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSG----ECIAKMFGHSEIITSMKFT 724

Query: 682 VNSQFLVSNSGDYEILYW 699
            +   L++ SGD  +  W
Sbjct: 725 YDCHHLITVSGDSCVFIW 742



 Score = 31.6 bits (70), Expect = 3.1
 Identities = 33/142 (23%), Positives = 60/142 (42%), Gaps = 8/142 (5%)

Query: 571 DAVGHRPVWDKIIEDPAQ-SSGFHPSGSVVAVGTLTGRWFVF-DTETKDLVTVHTDGNEQ 628
           + V +R   +K++   AQ SSG         V  L G   V  D +      +     + 
Sbjct: 54  ETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKS 113

Query: 629 LSVMRYSPDGNFLAIG--SHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQF 686
           LS + +SPDG ++  G   H   + I+ V +      +V +  GH   +  + +S N + 
Sbjct: 114 LSALAFSPDGKYIVTGENGHRPAVRIWDVEEK----NQVAEMLGHKYGVACVAFSPNMKH 169

Query: 687 LVSNSGDYEILYWVPSACKQVV 708
           +VS    ++++  V    K +V
Sbjct: 170 IVSMGYQHDMVLNVWDWKKDIV 191


>gi|145580610 WD repeat domain 62 isoform 2 [Homo sapiens]
          Length = 1518

 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 62/198 (31%), Positives = 93/198 (46%), Gaps = 17/198 (8%)

Query: 212 AKVELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRH-YAGH 270
           A  E    R+ LE V G   ++         TG   Y    VVV+ + +E  Q+H +   
Sbjct: 51  ASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTA 110

Query: 271 NDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTL-HVIGIGFFDRAVT 329
              +  LA  PD   I TG+      +G +  P VRIWD    N +  ++G  +    V 
Sbjct: 111 RKSLSALAFSPDGKYIVTGE------NGHR--PAVRIWDVEEKNQVAEMLGHKY---GVA 159

Query: 330 CIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVT 389
           C+AFS +    ++ ++   +D VL+VWDW+K+  +A  K S   V A  F   D++  VT
Sbjct: 160 CVAFSPNM--KHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCR-VIALSF-SEDSSYFVT 215

Query: 390 CGKSHLYFWTLEGSSLNK 407
            G  H+ FW LE S+  K
Sbjct: 216 VGNRHVRFWFLEVSTETK 233



 Score = 32.0 bits (71), Expect = 2.4
 Identities = 21/78 (26%), Positives = 33/78 (42%), Gaps = 5/78 (6%)

Query: 623 TDGNE-QLSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWS 681
           + G+E  L  +   P G FLA    D  I +            + K  GHS  IT + ++
Sbjct: 669 SQGDEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSG----ECIAKMFGHSEIITSMKFT 724

Query: 682 VNSQFLVSNSGDYEILYW 699
            +   L++ SGD  +  W
Sbjct: 725 YDCHHLITVSGDSCVFIW 742



 Score = 31.6 bits (70), Expect = 3.1
 Identities = 33/142 (23%), Positives = 60/142 (42%), Gaps = 8/142 (5%)

Query: 571 DAVGHRPVWDKIIEDPAQ-SSGFHPSGSVVAVGTLTGRWFVF-DTETKDLVTVHTDGNEQ 628
           + V +R   +K++   AQ SSG         V  L G   V  D +      +     + 
Sbjct: 54  ETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKS 113

Query: 629 LSVMRYSPDGNFLAIG--SHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQF 686
           LS + +SPDG ++  G   H   + I+ V +      +V +  GH   +  + +S N + 
Sbjct: 114 LSALAFSPDGKYIVTGENGHRPAVRIWDVEEK----NQVAEMLGHKYGVACVAFSPNMKH 169

Query: 687 LVSNSGDYEILYWVPSACKQVV 708
           +VS    ++++  V    K +V
Sbjct: 170 IVSMGYQHDMVLNVWDWKKDIV 191


>gi|190684671 mitogen-activated protein kinase binding protein 1
           isoform a [Homo sapiens]
          Length = 1508

 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 66/224 (29%), Positives = 95/224 (42%), Gaps = 26/224 (11%)

Query: 187 VKMFLRGRPVTMYMPKDQVDSYSLEAKVELPTKRLKLEWVYGYRGRDC--RNNLYLLPTG 244
           +K  LR   + +   K       L +KV L  K L +  V G RG  C  R+ L   P G
Sbjct: 12  IKNLLRSPSIKLRRSKAGNRREDLSSKVTLE-KVLGIT-VSGGRGLACDPRSGLVAYPAG 69

Query: 245 ETVYFIASVVVLYNVEEQLQRHYAGHN-DDVKCLAVHPDRITIATGQVAGTSKDGKQLPP 303
                   VVVL+N  +  Q H    +   +  LA  PD   + TG+            P
Sbjct: 70  -------CVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHM--------P 114

Query: 304 HVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEK 363
            VR+WD    +   V  +      V C+AFS S     + +V   +D +++VW W+K   
Sbjct: 115 AVRVWDVAEHS--QVAELQEHKYGVACVAFSPS--AKYIVSVGYQHDMIVNVWAWKKNIV 170

Query: 364 LADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNK 407
           +A  K S+  V A  F   D +  VT G  H+ FW L+ S  +K
Sbjct: 171 VASNKVSSR-VTAVSFSE-DCSYFVTAGNRHIKFWYLDDSKTSK 212



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 63/249 (25%), Positives = 101/249 (40%), Gaps = 33/249 (13%)

Query: 594 PSGSVVAVGTLTGRWFVFDTET-KDLVTVHTDGNEQLSVMRYSPDGNF--LAIGSHDNCI 650
           P+G  +A G   G   V + ++  +++ V    +E L +    PD     LA  S D  I
Sbjct: 483 PNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLI 542

Query: 651 YIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNS-QFLVSNSGDYEILYWVPSACKQVVS 709
           ++    D GR+Y+       HSS IT + ++ +  Q  + + G  + +Y+  +A K    
Sbjct: 543 HVL---DAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYF-RTAQKSGDG 598

Query: 710 VETTRDIEWATYTCTLGFHVFGVWPEGSDGTD-----INAVCRAHEKKLL--STGDDFGK 762
           V+ TR       T      V   W   + G       I  +    +KKL   S G+D   
Sbjct: 599 VQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTL 658

Query: 763 VHLFSYPCSQFRAPS------HIYG-----------GHSSHVTNVDFLCEDSHLISTGGK 805
           + + + P   + A S       I+            GHS  VT + F  +  HLIS  G 
Sbjct: 659 IKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSG- 717

Query: 806 DTSIMQWRV 814
           D+ I  WR+
Sbjct: 718 DSCIFVWRL 726



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 74/384 (19%), Positives = 137/384 (35%), Gaps = 50/384 (13%)

Query: 349 NDHVLSVWDWQKEEKLADVKCS---NEAVFAADFHPT--DTN-------IIVTCGKSH-L 395
           NDH + VWD +  +K+  V  +   +  V++ + +P   D+N         +TC   + +
Sbjct: 358 NDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSDNTI 417

Query: 396 YFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTIT------GDSSGNILVWGK-GT 448
             W  E S ++    L         +  +    N   +       GD +   L+  + G 
Sbjct: 418 RLWNTESSGVHGST-LHRNILSSDLIKIIYVDGNTQALLDTELPGGDKADASLLDPRVGI 476

Query: 449 NRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTEIPEQFGPIRT 508
             +  +  G H      +  LR   L S      +++    +  ++   E  +    ++ 
Sbjct: 477 RSVCVSPNGQHLASGDRMGTLRVHELQSLS----EMLKVEAHDSEILCLEYSKPDTGLKL 532

Query: 509 VAEGKGDVIL--IGTTRNFVLQGTLSGDFTPITQGHTDELWGLAIHASKSQ--FLTCGHD 564
           +A    D ++  +   R + LQ TL          H+  +  +   AS  Q   ++CG D
Sbjct: 533 LASASRDRLIHVLDAGREYSLQQTLDE--------HSSSITAVKFAASDGQVRMISCGAD 584

Query: 565 KHATL------WDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTET--- 615
           K           D V        + +         PS    A+G       +F+  +   
Sbjct: 585 KSIYFRTAQKSGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQ 644

Query: 616 KDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFI 675
           K L       +  L  ++  P G ++A    D  + I+  S        V    GHS  +
Sbjct: 645 KKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSG----ECVATMFGHSEIV 700

Query: 676 THLDWSVNSQFLVSNSGDYEILYW 699
           T + +S + + L+S SGD  I  W
Sbjct: 701 TGMKFSNDCKHLISVSGDSCIFVW 724



 Score = 30.8 bits (68), Expect = 5.3
 Identities = 17/63 (26%), Positives = 31/63 (49%)

Query: 594 PSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIY 653
           PSG  +A         +FD  + + V      +E ++ M++S D   L   S D+CI+++
Sbjct: 665 PSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 724

Query: 654 GVS 656
            +S
Sbjct: 725 RLS 727


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 68/302 (22%), Positives = 117/302 (38%), Gaps = 26/302 (8%)

Query: 374 VFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEK-------QEKP--KFVLCV 424
           VF   ++P    +    G S    W L  +S +    L  +       Q+ P  K V  +
Sbjct: 172 VFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSL 231

Query: 425 TFSENGDTI-TGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRK 483
            ++  G  + TG   G   +W K  N  S    G H+G IFAL   + G  +   G D+ 
Sbjct: 232 DWNSEGTLLATGSYDGFARIWTKDGNLAS--TLGQHKGPIFALKWNKKGNFILSAGVDKT 289

Query: 484 LISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPIT--QG 541
            I W  +  +  K + P    P   V + + +      + +  +     G   PI   QG
Sbjct: 290 TIIWDAHTGEA-KQQFPFHSAPALDV-DWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQG 347

Query: 542 HTDELWGLAIHASKSQFLTCGHDKHATLW---------DAVGHRPVWDKIIEDPAQSSGF 592
           HT+E+  +    + +   +C  D    +W         D   H      I   P      
Sbjct: 348 HTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTN 407

Query: 593 HPSGSVV-AVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIY 651
           +P+ +++ A  +      ++D +    +   T   E +  + +SPDG +LA GS D C++
Sbjct: 408 NPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVH 467

Query: 652 IY 653
           I+
Sbjct: 468 IW 469



 Score = 36.6 bits (83), Expect = 0.096
 Identities = 31/145 (21%), Positives = 64/145 (44%), Gaps = 19/145 (13%)

Query: 348 SNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPT-------DTNIIVTCGK--SHLYFW 398
           S+D  L +W  +++  + D++  N+ ++   + PT       + N+++      S +  W
Sbjct: 368 SDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLW 427

Query: 399 TLE-GSSLNKKQGLFEKQEKPKFVLCVTFSENGDTI-TGDSSGNILVWGKGTNRISYAVQ 456
            ++ G  ++       K ++P  V  V FS +G  + +G     + +W   T  + ++ +
Sbjct: 428 DVDRGICIH----TLTKHQEP--VYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYR 481

Query: 457 GAHEGGIFALCMLRDGTLVSGGGKD 481
           G   GGIF +C    G  V     D
Sbjct: 482 GT--GGIFEVCWNAAGDKVGASASD 504


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 68/302 (22%), Positives = 113/302 (37%), Gaps = 26/302 (8%)

Query: 374 VFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQ---------EKPKFVLCV 424
           VF   ++P    +    G S    W L  +S      L  +             K V  +
Sbjct: 184 VFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSL 243

Query: 425 TFSENGDTI-TGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRK 483
            ++ NG  + TG   G   +W +  N  S    G H+G IFAL   R G  +   G D+ 
Sbjct: 244 DWNTNGTLLATGSYDGFARIWTEDGNLAS--TLGQHKGPIFALKWNRKGNYILSAGVDKT 301

Query: 484 LISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPIT--QG 541
            I W  +  +  K + P    P   V + + +      + +  +     G   P+   QG
Sbjct: 302 TIIWDAHTGEA-KQQFPFHSAPALDV-DWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQG 359

Query: 542 HTDELWGLAIHASKSQFLTCGHDKHATLW---------DAVGHRPVWDKIIEDPAQSSGF 592
           HT+E+  +    S     +C  D    +W         D   H      I   P   +  
Sbjct: 360 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATS 419

Query: 593 HPSGSVV-AVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIY 651
           +P+ +++ A  +      ++D E        T   E +  + +SPDG +LA GS D C++
Sbjct: 420 NPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVH 479

Query: 652 IY 653
           I+
Sbjct: 480 IW 481



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 32/144 (22%), Positives = 62/144 (43%), Gaps = 17/144 (11%)

Query: 348 SNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPT-------DTNIIVTCGK--SHLYFW 398
           S+D  L +W  ++E  + D++  N+ ++   + PT       ++NI++      S +  W
Sbjct: 380 SDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLW 439

Query: 399 TLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTI-TGDSSGNILVWGKGTNRISYAVQG 457
            +E            K ++P  V  V FS +G  + +G     + +W   +  + ++ +G
Sbjct: 440 DIERGVCTH---TLTKHQEP--VYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG 494

Query: 458 AHEGGIFALCMLRDGTLVSGGGKD 481
              GGIF +C    G  V     D
Sbjct: 495 T--GGIFEVCWNARGDKVGASASD 516


>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 68/302 (22%), Positives = 113/302 (37%), Gaps = 26/302 (8%)

Query: 374 VFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQ---------EKPKFVLCV 424
           VF   ++P    +    G S    W L  +S      L  +             K V  +
Sbjct: 184 VFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSL 243

Query: 425 TFSENGDTI-TGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRK 483
            ++ NG  + TG   G   +W +  N  S    G H+G IFAL   R G  +   G D+ 
Sbjct: 244 DWNTNGTLLATGSYDGFARIWTEDGNLAS--TLGQHKGPIFALKWNRKGNYILSAGVDKT 301

Query: 484 LISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPIT--QG 541
            I W  +  +  K + P    P   V + + +      + +  +     G   P+   QG
Sbjct: 302 TIIWDAHTGEA-KQQFPFHSAPALDV-DWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQG 359

Query: 542 HTDELWGLAIHASKSQFLTCGHDKHATLW---------DAVGHRPVWDKIIEDPAQSSGF 592
           HT+E+  +    S     +C  D    +W         D   H      I   P   +  
Sbjct: 360 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATS 419

Query: 593 HPSGSVV-AVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIY 651
           +P+ +++ A  +      ++D E        T   E +  + +SPDG +LA GS D C++
Sbjct: 420 NPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVH 479

Query: 652 IY 653
           I+
Sbjct: 480 IW 481



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 32/144 (22%), Positives = 62/144 (43%), Gaps = 17/144 (11%)

Query: 348 SNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPT-------DTNIIVTCGK--SHLYFW 398
           S+D  L +W  ++E  + D++  N+ ++   + PT       ++NI++      S +  W
Sbjct: 380 SDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLW 439

Query: 399 TLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTI-TGDSSGNILVWGKGTNRISYAVQG 457
            +E            K ++P  V  V FS +G  + +G     + +W   +  + ++ +G
Sbjct: 440 DIERGVCTH---TLTKHQEP--VYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG 494

Query: 458 AHEGGIFALCMLRDGTLVSGGGKD 481
              GGIF +C    G  V     D
Sbjct: 495 T--GGIFEVCWNARGDKVGASASD 516


>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 68/302 (22%), Positives = 113/302 (37%), Gaps = 26/302 (8%)

Query: 374 VFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQ---------EKPKFVLCV 424
           VF   ++P    +    G S    W L  +S      L  +             K V  +
Sbjct: 235 VFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSL 294

Query: 425 TFSENGDTI-TGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRK 483
            ++ NG  + TG   G   +W +  N  S    G H+G IFAL   R G  +   G D+ 
Sbjct: 295 DWNTNGTLLATGSYDGFARIWTEDGNLAS--TLGQHKGPIFALKWNRKGNYILSAGVDKT 352

Query: 484 LISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPIT--QG 541
            I W  +  +  K + P    P   V + + +      + +  +     G   P+   QG
Sbjct: 353 TIIWDAHTGEA-KQQFPFHSAPALDV-DWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQG 410

Query: 542 HTDELWGLAIHASKSQFLTCGHDKHATLW---------DAVGHRPVWDKIIEDPAQSSGF 592
           HT+E+  +    S     +C  D    +W         D   H      I   P   +  
Sbjct: 411 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATS 470

Query: 593 HPSGSVV-AVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIY 651
           +P+ +++ A  +      ++D E        T   E +  + +SPDG +LA GS D C++
Sbjct: 471 NPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVH 530

Query: 652 IY 653
           I+
Sbjct: 531 IW 532



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 32/144 (22%), Positives = 62/144 (43%), Gaps = 17/144 (11%)

Query: 348 SNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPT-------DTNIIVTCGK--SHLYFW 398
           S+D  L +W  ++E  + D++  N+ ++   + PT       ++NI++      S +  W
Sbjct: 431 SDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLW 490

Query: 399 TLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTI-TGDSSGNILVWGKGTNRISYAVQG 457
            +E            K ++P  V  V FS +G  + +G     + +W   +  + ++ +G
Sbjct: 491 DIERGVCTH---TLTKHQEP--VYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG 545

Query: 458 AHEGGIFALCMLRDGTLVSGGGKD 481
              GGIF +C    G  V     D
Sbjct: 546 T--GGIFEVCWNARGDKVGASASD 567


>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 68/302 (22%), Positives = 113/302 (37%), Gaps = 26/302 (8%)

Query: 374 VFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQ---------EKPKFVLCV 424
           VF   ++P    +    G S    W L  +S      L  +             K V  +
Sbjct: 235 VFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSL 294

Query: 425 TFSENGDTI-TGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRK 483
            ++ NG  + TG   G   +W +  N  S    G H+G IFAL   R G  +   G D+ 
Sbjct: 295 DWNTNGTLLATGSYDGFARIWTEDGNLAS--TLGQHKGPIFALKWNRKGNYILSAGVDKT 352

Query: 484 LISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPIT--QG 541
            I W  +  +  K + P    P   V + + +      + +  +     G   P+   QG
Sbjct: 353 TIIWDAHTGEA-KQQFPFHSAPALDV-DWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQG 410

Query: 542 HTDELWGLAIHASKSQFLTCGHDKHATLW---------DAVGHRPVWDKIIEDPAQSSGF 592
           HT+E+  +    S     +C  D    +W         D   H      I   P   +  
Sbjct: 411 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATS 470

Query: 593 HPSGSVV-AVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIY 651
           +P+ +++ A  +      ++D E        T   E +  + +SPDG +LA GS D C++
Sbjct: 471 NPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVH 530

Query: 652 IY 653
           I+
Sbjct: 531 IW 532



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 32/144 (22%), Positives = 62/144 (43%), Gaps = 17/144 (11%)

Query: 348 SNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPT-------DTNIIVTCGK--SHLYFW 398
           S+D  L +W  ++E  + D++  N+ ++   + PT       ++NI++      S +  W
Sbjct: 431 SDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLW 490

Query: 399 TLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTI-TGDSSGNILVWGKGTNRISYAVQG 457
            +E            K ++P  V  V FS +G  + +G     + +W   +  + ++ +G
Sbjct: 491 DIERGVCTH---TLTKHQEP--VYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG 545

Query: 458 AHEGGIFALCMLRDGTLVSGGGKD 481
              GGIF +C    G  V     D
Sbjct: 546 T--GGIFEVCWNARGDKVGASASD 567


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 64/301 (21%), Positives = 117/301 (38%), Gaps = 41/301 (13%)

Query: 538 ITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDAV---------GHRPVWDKIIEDPAQ 588
           + + H   L  +A++ S S F+T  +D+   LWD           GHR V   I  +   
Sbjct: 87  VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN--- 143

Query: 589 SSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDN 648
               +P G  +A G+      ++  ET            ++  + ++P    +A GS D 
Sbjct: 144 ----NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDT 199

Query: 649 CIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQV- 707
              ++ + +    YT      GHS+ I  L ++ +   +++ S D+ ++ W     ++V 
Sbjct: 200 TAKLWDIQNGEEVYT----LRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVN 255

Query: 708 VSVETTRDIEWATY--------------TCTLGFHVFGVWPEGSDGTD--INAVCRAHEK 751
           + +    +I  A++              TC L     G       G D  I   C  +  
Sbjct: 256 ILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTG 315

Query: 752 KLLSTGDDFGKVHLFSYPCSQFRAPSHIYGGHSSHVTNVDFLCEDSHLISTGGKDTSIMQ 811
           KL++T    G   +FS    +  A      GH   ++ + F  + +HL+ TG  D +   
Sbjct: 316 KLIATASADGTARIFSAATRKCIAKLE---GHEGEISKISFNPQGNHLL-TGSSDKTARI 371

Query: 812 W 812
           W
Sbjct: 372 W 372



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 74/380 (19%), Positives = 130/380 (34%), Gaps = 68/380 (17%)

Query: 328 VTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFH-PTDTNI 386
           +T +A +KS      C +  S D    +WD    E+L  ++     V+A  F+ P    I
Sbjct: 95  LTNVALNKSGS----CFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKI 150

Query: 387 IVTCGKSHLYFWTLE-GSSLNKKQGLFEKQEKPKFVLCVTFSENGDTI-TGDSSGNILVW 444
                      W++E G   +  +G   +      ++C++F+     + TG       +W
Sbjct: 151 ATGSFDKTCKLWSVETGKCYHTFRGHTAE------IVCLSFNPQSTLVATGSMDTTAKLW 204

Query: 445 GKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTEIPEQFG 504
                   Y ++G H   I +L     G  +  G  D  ++ W  +              
Sbjct: 205 DIQNGEEVYTLRG-HSAEIISLSFNTSGDRIITGSFDHTVVVWDAD-------------- 249

Query: 505 PIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPITQGHTDELWGLAIHASKSQFLTCGHD 564
                                      +G    I  GH  E+   + +   S  LT   D
Sbjct: 250 ---------------------------TGRKVNILIGHCAEISSASFNWDCSLILTGSMD 282

Query: 565 KHATLWDAVGHRPVWDKI-IEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHT 623
           K   LWDA   + V      +D    S F  +G ++A  +  G   +F   T+  +    
Sbjct: 283 KTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLE 342

Query: 624 DGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKC----SGHSSFITHLD 679
               ++S + ++P GN L  GS D    I+          + G+C     GH+  I    
Sbjct: 343 GHEGEISKISFNPQGNHLLTGSSDKTARIWD--------AQTGQCLQVLEGHTDEIFSCA 394

Query: 680 WSVNSQFLVSNSGDYEILYW 699
           ++     +++ S D     W
Sbjct: 395 FNYKGNIVITGSKDNTCRIW 414



 Score = 39.3 bits (90), Expect = 0.015
 Identities = 60/319 (18%), Positives = 112/319 (35%), Gaps = 69/319 (21%)

Query: 256 LYNVEEQLQRH-YAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLN 314
           L++VE     H + GH  ++ CL+ +P    +ATG +  T+K          +WD     
Sbjct: 161 LWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAK----------LWDIQNGE 210

Query: 315 TLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAV 374
            ++ +       +   I+ S +  G  +  +  S DH + VWD     K+  +      +
Sbjct: 211 EVYTLR----GHSAEIISLSFNTSGDRI--ITGSFDHTVVVWDADTGRKVNILIGHCAEI 264

Query: 375 FAADFHPTDTNIIVT--CGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDT 432
            +A F+  D ++I+T    K+   +    G  +    G  ++      +L   F   G  
Sbjct: 265 SSASFN-WDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDE------ILDSCFDYTGKL 317

Query: 433 I-TGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNY 491
           I T  + G   ++   T +    ++G HEG I  +     G  +  G  D+    W    
Sbjct: 318 IATASADGTARIFSAATRKCIAKLEG-HEGEISKISFNPQGNHLLTGSSDKTARIWDAQ- 375

Query: 492 QKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPITQGHTDELWGLAI 551
                                                   +G    + +GHTDE++  A 
Sbjct: 376 ----------------------------------------TGQCLQVLEGHTDEIFSCAF 395

Query: 552 HASKSQFLTCGHDKHATLW 570
           +   +  +T   D    +W
Sbjct: 396 NYKGNIVITGSKDNTCRIW 414


>gi|124028512 WD40-repeat protein upregulated in HCC isoform b [Homo
           sapiens]
          Length = 620

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 123/642 (19%), Positives = 242/642 (37%), Gaps = 77/642 (11%)

Query: 215 ELPTKRLKLEWVYGYRGRDCRNNLYLLPTG--------ETVYFIASVVVLYNVEEQLQRH 266
           E     L+L+ V G+ G         +PTG          +Y +   V++  +  + Q  
Sbjct: 8   EAQVAELELDAVIGFNGH--------VPTGLKCHPDQEHMIYPLGCTVLIQAINTKEQNF 59

Query: 267 YAGHNDDVKCLAVHPDRITIATGQVA--GTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFF 324
             GH ++V CLA+      IA+GQV   G   D       + +WD      L    +   
Sbjct: 60  LQGHGNNVSCLAISRSGEYIASGQVTFMGFKAD-------IILWDYKNRELL--ARLSLH 110

Query: 325 DRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAAD---FHP 381
              +  +AFS ++    L ++   +D  + VW   K + +     +   V  A    F  
Sbjct: 111 KGKIEALAFSPND--LYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSR 168

Query: 382 TDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTI-TGDSSGN 440
               + +T G   +  W L+  +        +  +  + V+ +   ++      G ++G+
Sbjct: 169 CRDEMFMTAGNGTIRVWELDLPNRKIWPTECQTGQLKRIVMSIGVDDDDSFFYLGTTTGD 228

Query: 441 ILVWGKGTNRISYA--VQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTE 498
           IL     T  ++     +     G+ A+  L+ G L+ G G    +   S  Y+ ++K +
Sbjct: 229 ILKMNPRTKLLTDVGPAKDKFSLGVSAIRCLKMGGLLVGSGAGLLVFCKSPGYKPIKKIQ 288

Query: 499 IPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDF--TPITQGHTDELWGLAIHASKS 556
           +  Q G       G+G   L+GT  + + + + + DF  T I   H D +  +      +
Sbjct: 289 L--QGGITSITLRGEGHQFLVGTEESHIYRVSFT-DFKETLIATCHFDAVEDIVFPFGTA 345

Query: 557 Q-FLTCGHDKHATLWDAVGHRPVWDKIIED-PAQSSGFHPSGSVVAVGTLTGRWFVFDTE 614
           + F TC   K   +W    +R +    + +       F   G  +      G+   F  E
Sbjct: 346 ELFATCA-KKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPE 404

Query: 615 TKDLVTVHTDGNE-QLSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSS 673
           T  L+ V  + +   ++ +  + D   +  G  +  + ++ +    +K     K   H S
Sbjct: 405 TGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALK--EHKS 462

Query: 674 FITHLDWSVNSQFLVSNSGDYEILYW----------------VPSACK-----QVVSVET 712
            ++ +    N++  V+ S D   + W                    C      Q+++  T
Sbjct: 463 SVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSGT 522

Query: 713 TRDIE-WATYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCS 771
            R I  W  +  T+   +     EGS    IN +    E     TG +   V ++ Y   
Sbjct: 523 DRKIAYWEVFDGTVIREL-----EGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEG 577

Query: 772 QFRAPSHIYGGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWR 813
           +    +H+  GHS ++T +     + +++S    D +I++W+
Sbjct: 578 EV---THVGVGHSGNITRIRISPGNQYIVSVSA-DGAILRWK 615


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 58/289 (20%), Positives = 109/289 (37%), Gaps = 22/289 (7%)

Query: 421 VLCVTFSENGDTI-TGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGG 479
           V CV FS N   + +G     ++VW       +Y   G H+  +  +     G L++ G 
Sbjct: 22  VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTG-HKDAVTCVNFSPSGHLLASGS 80

Query: 480 KDRKLISWSGNYQKLRKTEIPEQFGPIRTV---AEGKGDVILIGTTRNFVLQGTLSGDFT 536
           +D+ +  W  N  K   T        +R+V   ++G+   +     +   +  T    F 
Sbjct: 81  RDKTVRIWVPNV-KGESTVFRAHTATVRSVHFCSDGQS-FVTASDDKTVKVWATHRQKFL 138

Query: 537 PITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGF---- 592
                H + +            ++   DK   LWD         + +    +  GF    
Sbjct: 139 FSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR-----ECVHSYCEHGGFVTYV 193

Query: 593 --HPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCI 650
             HPSG+ +A   +     V+D  T  L+  +   +  ++ + + P GN+L   S D+ +
Sbjct: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTL 253

Query: 651 YIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYW 699
            I  + +    YT      GH    T + +S   ++  S   D +++ W
Sbjct: 254 KILDLMEGRLLYT----LHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 77/383 (20%), Positives = 141/383 (36%), Gaps = 37/383 (9%)

Query: 260 EEQLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVI 319
           +  L+RH+ GH D V C+       +I T Q+A  S D   +  H++        T H  
Sbjct: 8   DPSLERHFKGHRDAVTCV-----DFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGH-- 60

Query: 320 GIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADF 379
                  AVTC+ FS S    +L A   S D  + +W    + +    +     V +  F
Sbjct: 61  -----KDAVTCVNFSPSG---HLLA-SGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHF 111

Query: 380 HPTDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSG 439
                + +       +  W     + ++++ LF   +   +V C  FS +G  I   S  
Sbjct: 112 CSDGQSFVTASDDKTVKVW-----ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDD 166

Query: 440 -NILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTE 498
             + +W K +    ++    H G +  +     GT ++  G D  +  W     +L +  
Sbjct: 167 KTVKLWDKSSRECVHS-YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY 225

Query: 499 IPEQFGPIRTVAEGKGDVILIGTTRNFV-LQGTLSGDFTPITQGHTDELWGLAIHASKSQ 557
                          G+ ++  ++ + + +   + G       GH      +A   +   
Sbjct: 226 QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 285

Query: 558 FLTCGHDKHATLW----DAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDT 613
           F + G D+   +W    D V H  V  K+   PA  +    S   + V  L  R  + + 
Sbjct: 286 FASGGSDEQVMVWKSNFDIVDHGEV-TKVPRPPATLAS---SMGNLTVSILEQRLTLTED 341

Query: 614 ETKDLVTVHTDGNEQLSVMRYSP 636
           + K  +      N+QL + R +P
Sbjct: 342 KLKQCLE-----NQQLIMQRATP 359



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 51/214 (23%), Positives = 81/214 (37%), Gaps = 43/214 (20%)

Query: 627 EQLSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQF 686
           + ++ + +S +   LA GS D+C+ ++ +    R Y    + +GH   +T +++S +   
Sbjct: 20  DAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAY----RFTGHKDAVTCVNFSPSGHL 75

Query: 687 LVSNSGDYEILYWVPSA-------------------CKQVVSVETTRDIE----WATYTC 723
           L S S D  +  WVP+                    C    S  T  D +    WAT+  
Sbjct: 76  LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQ 135

Query: 724 TLGFHVFGVWPEGSDGTDINAVCRAH---EKKLLSTGDDFGKVHLFSYPCSQFRAPSHIY 780
              F         S    IN V  A    + +L+ +  D   V L+       R   H Y
Sbjct: 136 KFLF---------SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD---KSSRECVHSY 183

Query: 781 GGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRV 814
             H   VT VDF       I+  G D ++  W V
Sbjct: 184 CEHGGFVTYVDF-HPSGTCIAAAGMDNTVKVWDV 216


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 58/289 (20%), Positives = 109/289 (37%), Gaps = 22/289 (7%)

Query: 421 VLCVTFSENGDTI-TGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGG 479
           V CV FS N   + +G     ++VW       +Y   G H+  +  +     G L++ G 
Sbjct: 22  VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTG-HKDAVTCVNFSPSGHLLASGS 80

Query: 480 KDRKLISWSGNYQKLRKTEIPEQFGPIRTV---AEGKGDVILIGTTRNFVLQGTLSGDFT 536
           +D+ +  W  N  K   T        +R+V   ++G+   +     +   +  T    F 
Sbjct: 81  RDKTVRIWVPNV-KGESTVFRAHTATVRSVHFCSDGQS-FVTASDDKTVKVWATHRQKFL 138

Query: 537 PITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGF---- 592
                H + +            ++   DK   LWD         + +    +  GF    
Sbjct: 139 FSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR-----ECVHSYCEHGGFVTYV 193

Query: 593 --HPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCI 650
             HPSG+ +A   +     V+D  T  L+  +   +  ++ + + P GN+L   S D+ +
Sbjct: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTL 253

Query: 651 YIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYW 699
            I  + +    YT      GH    T + +S   ++  S   D +++ W
Sbjct: 254 KILDLMEGRLLYT----LHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 67/334 (20%), Positives = 122/334 (36%), Gaps = 29/334 (8%)

Query: 260 EEQLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVI 319
           +  L+RH+ GH D V C+       +I T Q+A  S D   +  H++        T H  
Sbjct: 8   DPSLERHFKGHRDAVTCV-----DFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGH-- 60

Query: 320 GIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADF 379
                  AVTC+ FS S    +L A   S D  + +W    + +    +     V +  F
Sbjct: 61  -----KDAVTCVNFSPSG---HLLA-SGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHF 111

Query: 380 HPTDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSG 439
                + +       +  W     + ++++ LF   +   +V C  FS +G  I   S  
Sbjct: 112 CSDGQSFVTASDDKTVKVW-----ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDD 166

Query: 440 -NILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTE 498
             + +W K +    ++    H G +  +     GT ++  G D  +  W     +L +  
Sbjct: 167 KTVKLWDKSSRECVHS-YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY 225

Query: 499 IPEQFGPIRTVAEGKGDVILIGTTRNFV-LQGTLSGDFTPITQGHTDELWGLAIHASKSQ 557
                          G+ ++  ++ + + +   + G       GH      +A   +   
Sbjct: 226 QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 285

Query: 558 FLTCGHDKHATLW----DAVGHRPVWDKIIEDPA 587
           F + G D+   +W    D V H  V  K+   PA
Sbjct: 286 FASGGSDEQVMVWKSNFDIVDHGEV-TKVPRPPA 318



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 52/229 (22%), Positives = 86/229 (37%), Gaps = 17/229 (7%)

Query: 289 GQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDS 348
           GQ   T+ D K     V++W   T     +  +      V C  FS          V  S
Sbjct: 115 GQSFVTASDDKT----VKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGR----LIVSAS 164

Query: 349 NDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKK 408
           +D  + +WD    E +         V   DFHP+ T I      + +  W +    L   
Sbjct: 165 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRL--- 221

Query: 409 QGLFEKQEKPKFVLCVTFSENGD-TITGDSSGNILVWGKGTNRISYAVQGAHEGGIFALC 467
             L   Q     V  ++F  +G+  IT  S   + +      R+ Y + G H+G    + 
Sbjct: 222 --LQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHG-HQGPATTVA 278

Query: 468 MLRDGTLVSGGGKDRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDV 516
             R G   + GG D +++ W  N+  +   E+ +   P  T+A   G++
Sbjct: 279 FSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNL 327



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 51/214 (23%), Positives = 81/214 (37%), Gaps = 43/214 (20%)

Query: 627 EQLSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQF 686
           + ++ + +S +   LA GS D+C+ ++ +    R Y    + +GH   +T +++S +   
Sbjct: 20  DAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAY----RFTGHKDAVTCVNFSPSGHL 75

Query: 687 LVSNSGDYEILYWVPSA-------------------CKQVVSVETTRDIE----WATYTC 723
           L S S D  +  WVP+                    C    S  T  D +    WAT+  
Sbjct: 76  LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQ 135

Query: 724 TLGFHVFGVWPEGSDGTDINAVCRAH---EKKLLSTGDDFGKVHLFSYPCSQFRAPSHIY 780
              F         S    IN V  A    + +L+ +  D   V L+       R   H Y
Sbjct: 136 KFLF---------SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD---KSSRECVHSY 183

Query: 781 GGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRV 814
             H   VT VDF       I+  G D ++  W V
Sbjct: 184 CEHGGFVTYVDF-HPSGTCIAAAGMDNTVKVWDV 216


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 49/209 (23%), Positives = 84/209 (40%), Gaps = 17/209 (8%)

Query: 287 ATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVD 346
           A GQ   T+ + K     +++W       L+   +      V C  FS        C   
Sbjct: 112 ADGQFLATASEDKS----IKVWSMYRQRFLY--SLYRHTHWVRCAKFSPDGRLIVSC--- 162

Query: 347 DSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLN 406
            S D  + +WD   ++ + +   S       DF+P+ T I        +  W +  + L 
Sbjct: 163 -SEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKL- 220

Query: 407 KKQGLFEKQEKPKFVLCVTFSENGD-TITGDSSGNILVWGKGTNRISYAVQGAHEGGIFA 465
               L   Q     V C++F  +G+  IT  S G + +      R+ Y +QG H G +F 
Sbjct: 221 ----LQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQG-HTGPVFT 275

Query: 466 LCMLRDGTLVSGGGKDRKLISWSGNYQKL 494
           +   + G L + GG D +++ W  N+ +L
Sbjct: 276 VSFSKGGELFASGGADTQVLLWRTNFDEL 304



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 54/286 (18%), Positives = 110/286 (38%), Gaps = 16/286 (5%)

Query: 421 VLCVTFSENGDTI-TGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGG 479
           +  +  S NG  + T      +++W    +  +Y   G H+  + ++     G L++   
Sbjct: 21  ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVG-HKDVVTSVQFSPHGNLLASAS 79

Query: 480 KDRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTT---RNFVLQGTLSGDFT 536
           +DR +  W  + ++ + +E      P+R+V +   D   + T    ++  +       F 
Sbjct: 80  RDRTVRLWIPD-KRGKFSEFKAHTAPVRSV-DFSADGQFLATASEDKSIKVWSMYRQRFL 137

Query: 537 PITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDP---AQSSGFH 593
                HT  +            ++C  DK   +WD    + V +    D    A    F+
Sbjct: 138 YSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN--FSDSVGFANFVDFN 195

Query: 594 PSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIY 653
           PSG+ +A         V+D     L+  +   +  ++ + + P GN+L   S D  + I 
Sbjct: 196 PSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKIL 255

Query: 654 GVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYW 699
            + +    YT      GH+  +  + +S   +   S   D ++L W
Sbjct: 256 DLLEGRLIYT----LQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 66/310 (21%), Positives = 108/310 (34%), Gaps = 24/310 (7%)

Query: 263 LQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIG 322
           L+R++ GH   +  L + P+   +AT     T        PH R +  V          G
Sbjct: 10  LERYFKGHKAAITSLDLSPNGKQLATASW-DTFLMLWNFKPHARAYRYV----------G 58

Query: 323 FFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPT 382
             D  VT + FS      NL A   S D  + +W   K  K ++ K     V + DF   
Sbjct: 59  HKD-VVTSVQFSPHG---NLLA-SASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSAD 113

Query: 383 DTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNIL 442
              +        +  W     S+ +++ L+       +V C  FS +G  I   S    +
Sbjct: 114 GQFLATASEDKSIKVW-----SMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTI 168

Query: 443 VWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTEIPEQ 502
                TN+          G    +     GT ++  G D+ +  W     KL +      
Sbjct: 169 KIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQ-HYQVH 227

Query: 503 FGPIRTVAEGKGDVILIGTTRNFVLQ--GTLSGDFTPITQGHTDELWGLAIHASKSQFLT 560
            G +  ++       LI  + +  L+    L G      QGHT  ++ ++       F +
Sbjct: 228 SGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFAS 287

Query: 561 CGHDKHATLW 570
            G D    LW
Sbjct: 288 GGADTQVLLW 297



 Score = 37.7 bits (86), Expect = 0.043
 Identities = 20/67 (29%), Positives = 31/67 (46%), Gaps = 4/67 (5%)

Query: 635 SPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDY 694
           SP+G  LA  S D  + ++    + R Y  VG    H   +T + +S +   L S S D 
Sbjct: 27  SPNGKQLATASWDTFLMLWNFKPHARAYRYVG----HKDVVTSVQFSPHGNLLASASRDR 82

Query: 695 EILYWVP 701
            +  W+P
Sbjct: 83  TVRLWIP 89


>gi|145279222 WD repeat domain 66 [Homo sapiens]
          Length = 1149

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 106/530 (20%), Positives = 190/530 (35%), Gaps = 99/530 (18%)

Query: 217 PTKRLKLEWVYGYRG-------RDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAG 269
           P   L + W +G+         R+ R  + L       Y  A   ++YNV    Q H  G
Sbjct: 245 PVYPLTMTWSFGWNSSLPVYYIREERQRVLL-------YVCAHTAIIYNVFRNNQYHLQG 297

Query: 270 HNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVT 329
           H + + CL V  DR  IAT          K     V IWDS T   +H I    FD    
Sbjct: 298 HANIISCLCVSEDRRWIATAD--------KGPDCLVIIWDSFTGIPVHTI----FDSCPE 345

Query: 330 ---CIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAAD----FHPT 382
               +A + ++    L  + D+    + +W W    +           +       F+PT
Sbjct: 346 GNGIMAMAMTHDAKYLATISDAEVQKVCIWKWTLAVETPACTLELPTEYGVQNYVTFNPT 405

Query: 383 DTNIIVTCGKSH--LYFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSEN------GDTIT 434
           +   +V+  K+    Y W  E  +L     L  ++   K V    FS++         ++
Sbjct: 406 NNKELVSNSKTRAIYYAWYEERDTLAHSAPLLTEKTFNKLV--GKFSQSIFHLNLTQILS 463

Query: 435 GDSSGNILVW------GKGTNRISY------AVQGAHEGGIFALCMLRDGTLVSGGGKDR 482
               G ++VW         +  + +       +    + GI  L  + D  +V+G  K  
Sbjct: 464 ATMEGKLVVWDIHRPPSSASTFLGFPYIKPCKLVHLQKEGITVLTTI-DSYIVTGDIKGN 522

Query: 483 --------KLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGD 534
                    +++W   Y  L+        G IRT++  K          N+    TL GD
Sbjct: 523 IKFYDHTLSIVNW---YSHLK-------LGAIRTLSFSKTPATPPTEKSNYPPDCTLKGD 572

Query: 535 FTPITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQ---SSG 591
              +                   F+    D  A ++         +K+  +P     +  
Sbjct: 573 LFVL-----------------RNFIIGTSD--AAVYHLTTDGTKLEKLFVEPKDAICAIS 613

Query: 592 FHPSGSVVAVGTLTGRWFVFDTETKD-LVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCI 650
            HP   ++A+G++ G   V++ E K  L +   +    +  + Y+P+G  L  G  +  +
Sbjct: 614 CHPYQPLIAIGSICGMIKVWNYENKQYLFSRVFEKGLGVQSLTYNPEGALLGAGFTEGTV 673

Query: 651 YIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWV 700
           YI        +     K S  S  +TH+ +S +SQ++ +    + +  ++
Sbjct: 674 YILDAMSLENESPEPFKYSRTS--VTHISFSHDSQYMATADRSFTVAVYM 721


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 40/166 (24%), Positives = 72/166 (43%), Gaps = 7/166 (4%)

Query: 536 TPITQGHTDELWGLAIHASKSQFLTCGHDKHATLW--DAVGHRPVWDKIIEDPAQSSGFH 593
           T + QGH   +W L I      F +  HD+ A LW  D      ++   + D      FH
Sbjct: 377 TVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLAD-VDCVKFH 435

Query: 594 PSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIY 653
           P+ + +A G+      ++  +  + V + T     +  + +SP+G +LA    D  + ++
Sbjct: 436 PNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLW 495

Query: 654 GVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYW 699
            ++      T   +  GH+  IT L +S +S  + S S D  +  W
Sbjct: 496 DLASG----TLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 43/178 (24%), Positives = 72/178 (40%), Gaps = 23/178 (12%)

Query: 532 SGDFTPITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDA---------VGHR-PVWDK 581
           +G    I +GH   ++     A  S  L+C  D     WD           GH  PVWD 
Sbjct: 331 AGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDL 390

Query: 582 IIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFL 641
              D +  S +  SGS       T R + FD      + ++      +  +++ P+ N+L
Sbjct: 391 ---DISPYSLYFASGS----HDRTARLWSFDRTYP--LRIYAGHLADVDCVKFHPNSNYL 441

Query: 642 AIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYW 699
           A GS D  + ++    + ++   V   +GH   +  L +S N ++L S   D  +  W
Sbjct: 442 ATGSTDKTVRLW----SAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLW 495



 Score = 39.3 bits (90), Expect = 0.015
 Identities = 36/168 (21%), Positives = 64/168 (38%), Gaps = 24/168 (14%)

Query: 538 ITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDA---------VGHRPVWDKIIEDPAQ 588
           I  GH  ++  +  H + +   T   DK   LW A          GHR         P  
Sbjct: 421 IYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHR--------GPVL 472

Query: 589 SSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDN 648
           S  F P+G  +A      R  ++D  +  L        + ++ + +SPD   +A  S DN
Sbjct: 473 SLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDN 532

Query: 649 CIYIYGVSD-------NGRKYTRVGKCSGHSSFITHLDWSVNSQFLVS 689
            + ++ + +       +G     VG  +G  S +  + +   +  LV+
Sbjct: 533 SVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVLSVQFMACNLLLVT 580



 Score = 36.2 bits (82), Expect = 0.13
 Identities = 30/125 (24%), Positives = 53/125 (42%), Gaps = 17/125 (13%)

Query: 265 RHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFF 324
           R YAGH  DV C+  HP+   +ATG    T          VR+W +   N++ +    F 
Sbjct: 420 RIYAGHLADVDCVKFHPNSNYLATGSTDKT----------VRLWSAQQGNSVRL----FT 465

Query: 325 DRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDT 384
                 ++ + S  G  L +  +  D  L +WD        +++   + + +  F P D+
Sbjct: 466 GHRGPVLSLAFSPNGKYLASAGE--DQRLKLWDLASGTLYKELRGHTDNITSLTFSP-DS 522

Query: 385 NIIVT 389
            +I +
Sbjct: 523 GLIAS 527



 Score = 30.4 bits (67), Expect = 6.9
 Identities = 21/78 (26%), Positives = 37/78 (47%), Gaps = 6/78 (7%)

Query: 423 CVTFSENGDTI-TGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKD 481
           CV F  N + + TG +   + +W       S  +   H G + +L    +G  ++  G+D
Sbjct: 431 CVKFHPNSNYLATGSTDKTVRLWSAQQGN-SVRLFTGHRGPVLSLAFSPNGKYLASAGED 489

Query: 482 RKLISW---SGN-YQKLR 495
           ++L  W   SG  Y++LR
Sbjct: 490 QRLKLWDLASGTLYKELR 507


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 59/291 (20%), Positives = 112/291 (38%), Gaps = 60/291 (20%)

Query: 419 KFVLCVTFSENGDTITGDSSGNIL-VWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSG 477
           K V  V FS NG+ +   S+  ++ +WG    +    + G H+ GI  +    D  L+  
Sbjct: 46  KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG-HKLGISDVAWSSDSNLLVS 104

Query: 478 GGKDRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTP 537
              D+ L  W  +  K  KT                                        
Sbjct: 105 ASDDKTLKIWDVSSGKCLKT---------------------------------------- 124

Query: 538 ITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDA-VGHRPVWDKIIEDPAQSSGFHPSG 596
             +GH++ ++    +   +  ++   D+   +WD   G          DP  +  F+  G
Sbjct: 125 -LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDG 183

Query: 597 SVVAVGTLTGRWFVFDTETKD-LVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGV 655
           S++   +  G   ++DT +   L T+  D N  +S +++SP+G ++   + DN + ++  
Sbjct: 184 SLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDY 243

Query: 656 SDNGRKYTRVGKC----SGHSS--FITHLDWSV-NSQFLVSNSGDYEILYW 699
           S         GKC    +GH +  +    ++SV   +++VS S D  +  W
Sbjct: 244 SK--------GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 28/77 (36%), Positives = 41/77 (53%), Gaps = 4/77 (5%)

Query: 629 LSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLV 688
           +S +++SP+G +LA  S D  I I+G  D   + T     SGH   I+ + WS +S  LV
Sbjct: 48  VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT----ISGHKLGISDVAWSSDSNLLV 103

Query: 689 SNSGDYEILYWVPSACK 705
           S S D  +  W  S+ K
Sbjct: 104 SASDDKTLKIWDVSSGK 120



 Score = 38.1 bits (87), Expect = 0.033
 Identities = 49/233 (21%), Positives = 84/233 (36%), Gaps = 12/233 (5%)

Query: 345 VDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSS 404
           V  S+D  L +WD    + L  +K  +  VF  +F+P    I+       +  W ++   
Sbjct: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162

Query: 405 LNKKQGLFEKQEKPKFVLCVTFSENGDTITGDS-SGNILVWGKGTNRISYAVQGAHEGGI 463
             K          P  V  V F+ +G  I   S  G   +W   + +    +       +
Sbjct: 163 CLK---TLPAHSDP--VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 217

Query: 464 FALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKT---EIPEQFGPIRTVAEGKGDVILIG 520
             +    +G  +     D  L  W  +  K  KT      E++      +   G  I+ G
Sbjct: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSG 277

Query: 521 TTRNFVLQGTL-SGDFTPITQGHTDELWGLAIHASKSQFLTCG--HDKHATLW 570
           +  N V    L + +     QGHTD +   A H +++   +    +DK   LW
Sbjct: 278 SEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 59/291 (20%), Positives = 112/291 (38%), Gaps = 60/291 (20%)

Query: 419 KFVLCVTFSENGDTITGDSSGNIL-VWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSG 477
           K V  V FS NG+ +   S+  ++ +WG    +    + G H+ GI  +    D  L+  
Sbjct: 46  KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG-HKLGISDVAWSSDSNLLVS 104

Query: 478 GGKDRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTP 537
              D+ L  W  +  K  KT                                        
Sbjct: 105 ASDDKTLKIWDVSSGKCLKT---------------------------------------- 124

Query: 538 ITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDA-VGHRPVWDKIIEDPAQSSGFHPSG 596
             +GH++ ++    +   +  ++   D+   +WD   G          DP  +  F+  G
Sbjct: 125 -LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDG 183

Query: 597 SVVAVGTLTGRWFVFDTETKD-LVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGV 655
           S++   +  G   ++DT +   L T+  D N  +S +++SP+G ++   + DN + ++  
Sbjct: 184 SLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDY 243

Query: 656 SDNGRKYTRVGKC----SGHSS--FITHLDWSV-NSQFLVSNSGDYEILYW 699
           S         GKC    +GH +  +    ++SV   +++VS S D  +  W
Sbjct: 244 SK--------GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 28/77 (36%), Positives = 41/77 (53%), Gaps = 4/77 (5%)

Query: 629 LSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLV 688
           +S +++SP+G +LA  S D  I I+G  D   + T     SGH   I+ + WS +S  LV
Sbjct: 48  VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT----ISGHKLGISDVAWSSDSNLLV 103

Query: 689 SNSGDYEILYWVPSACK 705
           S S D  +  W  S+ K
Sbjct: 104 SASDDKTLKIWDVSSGK 120



 Score = 38.1 bits (87), Expect = 0.033
 Identities = 49/233 (21%), Positives = 84/233 (36%), Gaps = 12/233 (5%)

Query: 345 VDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSS 404
           V  S+D  L +WD    + L  +K  +  VF  +F+P    I+       +  W ++   
Sbjct: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162

Query: 405 LNKKQGLFEKQEKPKFVLCVTFSENGDTITGDS-SGNILVWGKGTNRISYAVQGAHEGGI 463
             K          P  V  V F+ +G  I   S  G   +W   + +    +       +
Sbjct: 163 CLK---TLPAHSDP--VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 217

Query: 464 FALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKT---EIPEQFGPIRTVAEGKGDVILIG 520
             +    +G  +     D  L  W  +  K  KT      E++      +   G  I+ G
Sbjct: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSG 277

Query: 521 TTRNFVLQGTL-SGDFTPITQGHTDELWGLAIHASKSQFLTCG--HDKHATLW 570
           +  N V    L + +     QGHTD +   A H +++   +    +DK   LW
Sbjct: 278 SEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330


>gi|48762926 PWP2 periodic tryptophan protein homolog [Homo sapiens]
          Length = 919

 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 61/293 (20%), Positives = 104/293 (35%), Gaps = 33/293 (11%)

Query: 391 GKSHLYFWTLEGSS-LNKKQGLFEKQEKPKFVLCVTFSENGDTI-TGDSSGNILVWGKGT 448
           G   L  W  +  S + K+QG F        ++ + +S +G  I TG   G + VW    
Sbjct: 351 GLGQLLVWEWQSESYVLKQQGHFNS------MVALAYSPDGQYIVTGGDDGKVKVWNT-L 403

Query: 449 NRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWS-GNYQKLRKTEIPEQFGPIR 507
           +   +     H  G+  +     G +V     D  + ++    Y+  R    P       
Sbjct: 404 SGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSC 463

Query: 508 TVAEGKGDVILIGTTRNFVL--QGTLSGDFTPITQGHTDELWGLAIHASKSQFLTCGHDK 565
              +  G+++  G   +F +      +G    +  GH   + GL  +  KS   +   DK
Sbjct: 464 VAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDK 523

Query: 566 HATLWDAV-GHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETK-------- 616
              LWD     R      +   A +  F P G+ +AV TL  +   +D E          
Sbjct: 524 TVRLWDMFDSWRTKETLALTSDALAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEG 583

Query: 617 -----------DLVTV-HTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVSD 657
                      D +T  H    +  + + YS DG+ +  G     + IY V +
Sbjct: 584 RHDLKTGRKELDKITAKHAAKGKAFTALCYSADGHSILAGGMSKFVCIYHVRE 636



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 107/513 (20%), Positives = 168/513 (32%), Gaps = 118/513 (23%)

Query: 263 LQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIG 322
           L + Y G  D+  C+    D      G     SKD          WD++    L     G
Sbjct: 136 LDKTYFGPYDETTCIDWTDDSRCFVVG-----SKDMSTWVFGAERWDNLIYYALG----G 186

Query: 323 FFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWD---------------W--------Q 359
             D  V C  F +SN   +L     S D VL +W                W        +
Sbjct: 187 HKDAIVAC--FFESN---SLDLYSLSQDGVLCMWQCDTPPEGLRLKPPAGWKADLLQREE 241

Query: 360 KEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHL--YFWTLEG-------SSLNKKQ- 409
           +EE+  D +   E        P +         S L  YF+  EG       ++ +KK  
Sbjct: 242 EEEEEEDQEGDRETTIRGKATPAEEEKTGKVKYSRLAKYFFNKEGDFNNLTAAAFHKKSH 301

Query: 410 --------GLFEKQEKPKF------------VLCVTFSENGDTITGDSSG--NILVWGKG 447
                   G+F   E P+F            +  V  + +GD I    SG   +LVW   
Sbjct: 302 LLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCSGLGQLLVWEWQ 361

Query: 448 TNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTEIPEQFGPIR 507
           +       QG H   + AL    DG  +  GG D K+  W+                   
Sbjct: 362 SESYVLKQQG-HFNSMVALAYSPDGQYIVTGGDDGKVKVWN------------------- 401

Query: 508 TVAEGKGDVILIGTTRNFVLQGTLSGDFTPITQGHTDELWGLAIHASKSQFLTCGHDKHA 567
                                 TLSG        H+  + G+   A+    +T   D   
Sbjct: 402 ----------------------TLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTV 439

Query: 568 TLWDAVGHRPVWDKIIEDPAQSS--GFHPSGSVVAVGTLTG-RWFVFDTETKDLVTVHTD 624
             +D   +R         P Q S      SG +V+ G       FV+  +T  L+ V + 
Sbjct: 440 RAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSG 499

Query: 625 GNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNS 684
               +S + ++P  + LA  S D  + ++ + D+ R    +   S   +     D    +
Sbjct: 500 HEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPD---GA 556

Query: 685 QFLVSNSGDYEILYWVPSACKQVVSVETTRDIE 717
           +  V+     +I +W P    Q  S+E   D++
Sbjct: 557 ELAVATLNS-QITFWDPENAVQTGSIEGRHDLK 588


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.133    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,933,065
Number of Sequences: 37866
Number of extensions: 1575467
Number of successful extensions: 7270
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 115
Number of HSP's successfully gapped in prelim test: 236
Number of HSP's that attempted gapping in prelim test: 5783
Number of HSP's gapped (non-prelim): 1360
length of query: 815
length of database: 18,247,518
effective HSP length: 111
effective length of query: 704
effective length of database: 14,044,392
effective search space: 9887251968
effective search space used: 9887251968
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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