BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] (1302 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 2589 0.0 gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 2411 0.0 gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 698 0.0 gi|45827729 scribble isoform b [Homo sapiens] 389 e-107 gi|45827731 scribble isoform a [Homo sapiens] 389 e-107 gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 375 e-103 gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 190 9e-48 gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 173 8e-43 gi|238908508 leucine-rich repeat and death domain-containing pro... 170 7e-42 gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 150 6e-36 gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 149 2e-35 gi|4503743 flightless I homolog [Homo sapiens] 139 2e-32 gi|65301141 PH domain and leucine rich repeat protein phosphatas... 124 8e-28 gi|197333692 leucine rich repeat containing 8 family, member B [... 123 1e-27 gi|21245134 leucine rich repeat containing 8 family, member B [H... 123 1e-27 gi|40217803 leucine rich repeat containing 8 family, member E [H... 120 6e-27 gi|62241040 leucine rich repeat containing 8 family, member A [H... 115 4e-25 gi|187829877 leucine rich repeat containing 8 family, member A [... 115 4e-25 gi|187829871 leucine rich repeat containing 8 family, member A [... 115 4e-25 gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 114 8e-25 gi|19923729 leucine rich repeat containing 8 family, member C [H... 112 2e-24 gi|61742786 leucine rich repeat and death domain containing prot... 112 3e-24 gi|61742784 leucine rich repeat and death domain containing prot... 112 3e-24 gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 111 4e-24 gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 111 4e-24 gi|197333706 leucine rich repeat containing 8 family, member D [... 110 7e-24 gi|34222199 leucine rich repeat containing 8 family, member D [H... 110 7e-24 gi|37221175 PH domain and leucine rich repeat protein phosphatas... 105 4e-22 gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 105 4e-22 gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 105 4e-22 >gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] Length = 1302 Score = 2589 bits (6710), Expect = 0.0 Identities = 1302/1302 (100%), Positives = 1302/1302 (100%) Query: 1 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 60 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE Sbjct: 1 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 60 Query: 61 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV Sbjct: 61 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120 Query: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM Sbjct: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180 Query: 181 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN Sbjct: 181 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240 Query: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 300 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS Sbjct: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 300 Query: 301 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 360 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL Sbjct: 301 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 360 Query: 361 PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 420 PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM Sbjct: 361 PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 420 Query: 421 VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 480 VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL Sbjct: 421 VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 480 Query: 481 KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT 540 KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT Sbjct: 481 KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT 540 Query: 541 TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE 600 TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE Sbjct: 541 TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE 600 Query: 601 LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS 660 LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS Sbjct: 601 LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS 660 Query: 661 PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF 720 PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF Sbjct: 661 PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF 720 Query: 721 KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI 780 KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI Sbjct: 721 KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI 780 Query: 781 MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD 840 MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD Sbjct: 781 MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD 840 Query: 841 SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK 900 SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK Sbjct: 841 SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK 900 Query: 901 ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG 960 ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG Sbjct: 901 ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG 960 Query: 961 PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS 1020 PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS Sbjct: 961 PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS 1020 Query: 1021 YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV 1080 YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV Sbjct: 1021 YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV 1080 Query: 1081 SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS 1140 SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS Sbjct: 1081 SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS 1140 Query: 1141 RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV 1200 RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV Sbjct: 1141 RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV 1200 Query: 1201 LRHIEAKKLEKIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQ 1260 LRHIEAKKLEKIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQ Sbjct: 1201 LRHIEAKKLEKIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQ 1260 Query: 1261 PGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS 1302 PGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS Sbjct: 1261 PGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS 1302 >gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] Length = 1371 Score = 2411 bits (6248), Expect = 0.0 Identities = 1211/1212 (99%), Positives = 1212/1212 (100%) Query: 1 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 60 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE Sbjct: 1 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 60 Query: 61 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV Sbjct: 61 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120 Query: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM Sbjct: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180 Query: 181 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN Sbjct: 181 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240 Query: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 300 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS Sbjct: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 300 Query: 301 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 360 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL Sbjct: 301 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 360 Query: 361 PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 420 PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM Sbjct: 361 PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 420 Query: 421 VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 480 VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL Sbjct: 421 VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 480 Query: 481 KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT 540 KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT Sbjct: 481 KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT 540 Query: 541 TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE 600 TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE Sbjct: 541 TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE 600 Query: 601 LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS 660 LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS Sbjct: 601 LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS 660 Query: 661 PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF 720 PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF Sbjct: 661 PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF 720 Query: 721 KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI 780 KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI Sbjct: 721 KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI 780 Query: 781 MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD 840 MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD Sbjct: 781 MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD 840 Query: 841 SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK 900 SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK Sbjct: 841 SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK 900 Query: 901 ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG 960 ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG Sbjct: 901 ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG 960 Query: 961 PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS 1020 PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS Sbjct: 961 PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS 1020 Query: 1021 YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV 1080 YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV Sbjct: 1021 YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV 1080 Query: 1081 SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS 1140 SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS Sbjct: 1081 SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS 1140 Query: 1141 RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV 1200 RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV Sbjct: 1141 RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV 1200 Query: 1201 LRHIEAKKLEKI 1212 LRHIEAKKLEK+ Sbjct: 1201 LRHIEAKKLEKM 1212 >gi|16904383 leucine rich repeat containing 7 [Homo sapiens] Length = 1537 Score = 698 bits (1801), Expect = 0.0 Identities = 385/708 (54%), Positives = 481/708 (67%), Gaps = 42/708 (5%) Query: 1 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 60 MTTKR + RLVPCRC RGEEE ++ LDYSHCSL+QVPKE+F FE+TLEELYLDANQIEE Sbjct: 1 MTTKRKIIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEE 60 Query: 61 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120 LPKQLFNCQ+L KLS+PDNDL+ LP +IA+L+NL+ELD+SKNG+QEFPENIK CK LTI+ Sbjct: 61 LPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTII 120 Query: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180 EASVNPISKLPDGF+QLLNLTQLYLNDAFLEFLPANFGRL KL+ILELREN LK LPK+M Sbjct: 121 EASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSM 180 Query: 181 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240 ++L QLERLDLG+NEF E+PEVL+Q+ L+E WMD N L +PG IG LK L YLD+SKN Sbjct: 181 HKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKN 240 Query: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 300 IE V+ IS CE L+DLLLSSN LQQLP++IG LK +TTLK+D+NQL LP++IG L Sbjct: 241 RIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSL 300 Query: 301 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 360 +EE DCS NE+E+LPS+IG L +LRT A D N+L +LP EIGS KN+TV+ L SNKLE L Sbjct: 301 LEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFL 360 Query: 361 PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 420 PEE+G MQKL+V+NLSDNRLKNLPFSFTKL++L A+WLSDNQSK LIPLQ E ET++ Sbjct: 361 PEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQR 420 Query: 421 VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 480 VLTNYMFPQQPR D F SD++SFNP+LWEEQR+QR VAFE ++ K++ E G + Sbjct: 421 VLTNYMFPQQPR-GDEDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDE---NAGKV 476 Query: 481 KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLK------PHED----------- 523 K P E T+Q RL + + D + P D Sbjct: 477 KDLSCQAPWERGQRGITLQPA--RLSGDCCTPWARCDQQIQDMPVPQNDPQLAWGCISGL 534 Query: 524 QQDINKDVGVKTSESTTTVKS---------------KVDEREKYMIGNSVQKISEPEAEI 568 QQ+ + + + +TT+ S E K M+ + + +P + Sbjct: 535 QQERSMCTPLPVAAQSTTLPSLSGRQVEINLKRYPTPYPEDLKNMVKSVQNLVGKPSHGV 594 Query: 569 SPGSLPVTAN----MKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQP 624 + TAN +K K V ++ E + EM++ E+ P L ET + P Sbjct: 595 RVENSNPTANTEQTVKEKYEHKWPVAPKEITVEDSFVHPANEMRIGELHPSLAETPLYPP 654 Query: 625 KVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNT 672 K+V L +KK+ T E++ +NS + + + S S NT Sbjct: 655 KLVLLGKDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSGSSNT 702 Score = 139 bits (351), Expect = 1e-32 Identities = 64/92 (69%), Positives = 82/92 (89%) Query: 1210 EKIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQAN 1269 E+ VR+EK+P LGFSISGG+ G+GNPF+P D GIFVTRVQP+GPAS LLQPGDKI+QAN Sbjct: 1445 EQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNLLQPGDKILQAN 1504 Query: 1270 GYSFINIEHGQAVSLLKTFQNTVELIIVREVS 1301 G+SF+++EH +AV LLK+FQNTV+L+I RE++ Sbjct: 1505 GHSFVHMEHEKAVLLLKSFQNTVDLVIQRELT 1536 >gi|45827729 scribble isoform b [Homo sapiens] Length = 1630 Score = 389 bits (998), Expect = e-107 Identities = 225/553 (40%), Positives = 333/553 (60%), Gaps = 15/553 (2%) Query: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83 V ++D HCSL+ VP+EI+ + ++LEEL LDANQ+ ELPK F +L KL L DN++ Sbjct: 14 VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQR 73 Query: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143 LP +AN + L ELDVS+N I E PE+IK CK L I + S NP+S+LPDGF+QL +L L Sbjct: 74 LPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHL 133 Query: 144 YLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203 LND L+ LP + G L L LELREN LK LP +++ L +LE+LDLG N+ +P+ L Sbjct: 134 ALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTL 193 Query: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263 L L+E W+D N+L+ +P +G+L++L LDVS+N +E + + L DLLLS N Sbjct: 194 GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253 Query: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTN 323 L++LP+ IG LK ++ LK+D+N+L + ++IG ++ EL + N + ALP S+G+LT Sbjct: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313 Query: 324 LRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNL 383 L D N+L+ LPPEIG ++VL L N+L LP E+ +L V++++ NRL++L Sbjct: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSL 373 Query: 384 PFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQP--RTEDVMFISD 441 PF+ T L L A+WL++NQ++P++ Q E D+ T + VLT Y+ PQQP ED + Sbjct: 374 PFALTHL-NLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPLSLED----AG 428 Query: 442 NESFNPSLWEEQRKQRAQVAFECDE---DKDEREAPPREGNLKRYPTPYPDELKNMVKTV 498 + W + R V + D+D EA + L+R TP+P ELK M +++ Sbjct: 429 QQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSELKVMKRSI 488 Query: 499 QTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTTTVKSKVDEREKYMIGNSV 558 + R + DSG L P E+++ ++ + G+ SE + S V E E Sbjct: 489 EG--RRSEACPCQPDSGSPL-PAEEEKRLSAESGL--SEDSRPSASTVSEAEPEGPSAEA 543 Query: 559 QKISEPEAEISPG 571 Q S+ EA + G Sbjct: 544 QGGSQQEATTAGG 556 Score = 64.7 bits (156), Expect = 6e-10 Identities = 50/188 (26%), Positives = 89/188 (47%), Gaps = 12/188 (6%) Query: 1119 MMPGSQRPLSARTYSIDGPNAS---RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNA 1175 M P + P++ + +GP+A R Q E + + +R + Sbjct: 632 MQPDGEGPVAPGGWH-NGPHAPWAPRAQKEEEEEEEGSPQEEEEEEEEENRAEEEEASTE 690 Query: 1176 RVGSEHSLLDPPGKSKVPRDWREQVLRHIEAKKLEKIRVRV---EKDPELGFSISGGVGG 1232 E +++ P V D +L IE ++E+ + + + LG SI+GG G Sbjct: 691 EEDKEGAVVSAPSVKGVSFDQANNLL--IEPARIEEEELTLTILRQTGGLGISIAGGKGS 748 Query: 1233 RGNPFRPDDDGIFVTRVQPEGPASKL-LQPGDKIIQANGYSFINIEHGQAVSLLKTFQNT 1291 P++ DD+GIF++RV EGPA++ ++ GDK+++ NG + EH +AV L+ Sbjct: 749 --TPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTA 806 Query: 1292 VELIIVRE 1299 V++ + RE Sbjct: 807 VQMRVWRE 814 Score = 60.8 bits (146), Expect = 8e-09 Identities = 32/86 (37%), Positives = 54/86 (62%), Gaps = 5/86 (5%) Query: 1216 VEKDP--ELGFSISGGVGGR-GNPFRPDDDGIFVTRVQPEGPASK--LLQPGDKIIQANG 1270 ++K P LG SI GG G GNP P D+GIF+++V P G A + L+ G ++++ N Sbjct: 1103 IQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQ 1162 Query: 1271 YSFINIEHGQAVSLLKTFQNTVELII 1296 S + + HG+AV LL++ +T+ +++ Sbjct: 1163 QSLLGLTHGEAVQLLRSVGDTLTVLV 1188 Score = 60.1 bits (144), Expect = 1e-08 Identities = 34/80 (42%), Positives = 45/80 (56%), Gaps = 4/80 (5%) Query: 1222 LGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASK--LLQPGDKIIQANGYSFINIEHG 1279 LGFSI+GG G P+R D GIFV+R+ G A + LQ GD+++ NG H Sbjct: 872 LGFSIAGGKGS--TPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHD 929 Query: 1280 QAVSLLKTFQNTVELIIVRE 1299 AVSLL T+ L++ RE Sbjct: 930 HAVSLLTAASPTIALLLERE 949 Score = 48.9 bits (115), Expect = 3e-05 Identities = 37/118 (31%), Positives = 57/118 (48%), Gaps = 3/118 (2%) Query: 1170 SKRPNARVGSEHSLLDPPGKSKVPRDWREQVLRHIEAK-KLEKIRVRVEKDPELGFSISG 1228 S P A V + PG +P + +E +E+IR+ P LG SI G Sbjct: 962 SSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGP-LGLSIVG 1020 Query: 1229 GVGGRGNPFRPDDDGIFVTRVQPEGPASKL-LQPGDKIIQANGYSFINIEHGQAVSLL 1285 G +PF + G+F+++V P G A++ L+ GD+I+ NG + H +AVS L Sbjct: 1021 GSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSAL 1078 >gi|45827731 scribble isoform a [Homo sapiens] Length = 1655 Score = 389 bits (998), Expect = e-107 Identities = 225/553 (40%), Positives = 333/553 (60%), Gaps = 15/553 (2%) Query: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83 V ++D HCSL+ VP+EI+ + ++LEEL LDANQ+ ELPK F +L KL L DN++ Sbjct: 14 VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQR 73 Query: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143 LP +AN + L ELDVS+N I E PE+IK CK L I + S NP+S+LPDGF+QL +L L Sbjct: 74 LPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHL 133 Query: 144 YLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203 LND L+ LP + G L L LELREN LK LP +++ L +LE+LDLG N+ +P+ L Sbjct: 134 ALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTL 193 Query: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263 L L+E W+D N+L+ +P +G+L++L LDVS+N +E + + L DLLLS N Sbjct: 194 GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253 Query: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTN 323 L++LP+ IG LK ++ LK+D+N+L + ++IG ++ EL + N + ALP S+G+LT Sbjct: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313 Query: 324 LRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNL 383 L D N+L+ LPPEIG ++VL L N+L LP E+ +L V++++ NRL++L Sbjct: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSL 373 Query: 384 PFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQP--RTEDVMFISD 441 PF+ T L L A+WL++NQ++P++ Q E D+ T + VLT Y+ PQQP ED + Sbjct: 374 PFALTHL-NLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPLSLED----AG 428 Query: 442 NESFNPSLWEEQRKQRAQVAFECDE---DKDEREAPPREGNLKRYPTPYPDELKNMVKTV 498 + W + R V + D+D EA + L+R TP+P ELK M +++ Sbjct: 429 QQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSELKVMKRSI 488 Query: 499 QTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTTTVKSKVDEREKYMIGNSV 558 + R + DSG L P E+++ ++ + G+ SE + S V E E Sbjct: 489 EG--RRSEACPCQPDSGSPL-PAEEEKRLSAESGL--SEDSRPSASTVSEAEPEGPSAEA 543 Query: 559 QKISEPEAEISPG 571 Q S+ EA + G Sbjct: 544 QGGSQQEATTAGG 556 Score = 64.7 bits (156), Expect = 6e-10 Identities = 50/188 (26%), Positives = 89/188 (47%), Gaps = 12/188 (6%) Query: 1119 MMPGSQRPLSARTYSIDGPNAS---RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNA 1175 M P + P++ + +GP+A R Q E + + +R + Sbjct: 632 MQPDGEGPVAPGGWH-NGPHAPWAPRAQKEEEEEEEGSPQEEEEEEEEENRAEEEEASTE 690 Query: 1176 RVGSEHSLLDPPGKSKVPRDWREQVLRHIEAKKLEKIRVRV---EKDPELGFSISGGVGG 1232 E +++ P V D +L IE ++E+ + + + LG SI+GG G Sbjct: 691 EEDKEGAVVSAPSVKGVSFDQANNLL--IEPARIEEEELTLTILRQTGGLGISIAGGKGS 748 Query: 1233 RGNPFRPDDDGIFVTRVQPEGPASKL-LQPGDKIIQANGYSFINIEHGQAVSLLKTFQNT 1291 P++ DD+GIF++RV EGPA++ ++ GDK+++ NG + EH +AV L+ Sbjct: 749 --TPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTA 806 Query: 1292 VELIIVRE 1299 V++ + RE Sbjct: 807 VQMRVWRE 814 Score = 60.8 bits (146), Expect = 8e-09 Identities = 32/86 (37%), Positives = 54/86 (62%), Gaps = 5/86 (5%) Query: 1216 VEKDP--ELGFSISGGVGGR-GNPFRPDDDGIFVTRVQPEGPASK--LLQPGDKIIQANG 1270 ++K P LG SI GG G GNP P D+GIF+++V P G A + L+ G ++++ N Sbjct: 1103 IQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQ 1162 Query: 1271 YSFINIEHGQAVSLLKTFQNTVELII 1296 S + + HG+AV LL++ +T+ +++ Sbjct: 1163 QSLLGLTHGEAVQLLRSVGDTLTVLV 1188 Score = 60.1 bits (144), Expect = 1e-08 Identities = 34/80 (42%), Positives = 45/80 (56%), Gaps = 4/80 (5%) Query: 1222 LGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASK--LLQPGDKIIQANGYSFINIEHG 1279 LGFSI+GG G P+R D GIFV+R+ G A + LQ GD+++ NG H Sbjct: 872 LGFSIAGGKGS--TPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHD 929 Query: 1280 QAVSLLKTFQNTVELIIVRE 1299 AVSLL T+ L++ RE Sbjct: 930 HAVSLLTAASPTIALLLERE 949 Score = 48.9 bits (115), Expect = 3e-05 Identities = 37/118 (31%), Positives = 57/118 (48%), Gaps = 3/118 (2%) Query: 1170 SKRPNARVGSEHSLLDPPGKSKVPRDWREQVLRHIEAK-KLEKIRVRVEKDPELGFSISG 1228 S P A V + PG +P + +E +E+IR+ P LG SI G Sbjct: 962 SSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGP-LGLSIVG 1020 Query: 1229 GVGGRGNPFRPDDDGIFVTRVQPEGPASKL-LQPGDKIIQANGYSFINIEHGQAVSLL 1285 G +PF + G+F+++V P G A++ L+ GD+I+ NG + H +AVS L Sbjct: 1021 GSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSAL 1078 >gi|95113664 leucine rich repeat containing 1 [Homo sapiens] Length = 524 Score = 375 bits (962), Expect = e-103 Identities = 213/514 (41%), Positives = 308/514 (59%), Gaps = 16/514 (3%) Query: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83 V ++D HCSL VP+EI+ + ++LEEL LDANQ+ ELP+Q F L KL L DN++ Sbjct: 14 VESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQR 73 Query: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143 LP IAN + L ELDVS+N I E PE+I CK L + + S NP+++LP+ F +L NLT L Sbjct: 74 LPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCL 133 Query: 144 YLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203 +ND L+ LP N G L L LELREN L LP ++ +L +LE LDLG+NE +PE + Sbjct: 134 SVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESI 193 Query: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263 L LK+ W+D N+L+ +P IG+LK L LDVS+N +E + E IS +L DL++S N Sbjct: 194 GALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQN 253 Query: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTN 323 L+ +P+ IG LK ++ LK+D+N+L LP+++G S+ EL + N++ LP SIG+L Sbjct: 254 LLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKK 313 Query: 324 LRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNL 383 L AD N L LP EIG ++TV + N+L +P E+ +L V++++ NRL +L Sbjct: 314 LSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHL 373 Query: 384 PFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPR----TEDVMFI 439 P S T L +L A+WLSDNQS+PL+ Q +TD T + +LT + PQ P E++ Sbjct: 374 PLSLTAL-KLKALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLPSEPTCQENLPRC 432 Query: 440 SDNESF----NPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMV 495 E+ + W E+ R +++KDE + R L R TP+P ELK+M Sbjct: 433 GALENLVNDVSDEAWNERAVNRVSAIRFVEDEKDEEDNETR--TLLRRATPHPGELKHMK 490 Query: 496 KTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINK 529 KTV+ + + N G D +E I++ Sbjct: 491 KTVENL-----RNDMNAAKGLDSNKNEVNHAIDR 519 >gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] Length = 582 Score = 190 bits (482), Expect = 9e-48 Identities = 132/453 (29%), Positives = 208/453 (45%), Gaps = 50/453 (11%) Query: 21 EETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDND 80 EE LD S S+ +P I + L ELYL +N+++ LP ++ +L L+L +N Sbjct: 99 EENSMRLDLSKRSIHILPSSIKELTQ-LTELYLYSNKLQSLPAEVGCLVNLMTLALSENS 157 Query: 81 LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNL 140 LT+LP S+ NL LR LD+ N ++E P + LT + N I+ + L L Sbjct: 158 LTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKL 217 Query: 141 TQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP 200 + L + + ++ LPA G L L L++ NQL+ LPK + TQ+ LDL NE ++P Sbjct: 218 SMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLP 277 Query: 201 EVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGI----------- 249 + + LS L + NRL+ IP + L L++ NNI + E + Sbjct: 278 DTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLT 337 Query: 250 --------------------------------------STCENLQDLLLSSNSLQQLPET 271 S + L L + N L LP Sbjct: 338 LARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLD 397 Query: 272 IGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADH 331 G+ ++ L + NQL +P+ + GL+S+E L S N ++ LP +G L LR + Sbjct: 398 FGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEE 457 Query: 332 NYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQ 391 N L+ LP EI K++ L L +N+L TLP +G + L + L +N L +LP L+ Sbjct: 458 NKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLE 517 Query: 392 QLTAMWLSDNQSKPLIPLQKETDSETQKMVLTN 424 L ++L+DN + +P + S+ M + N Sbjct: 518 NLEELYLNDNPNLHSLPFELALCSKLSIMSIEN 550 Score = 177 bits (450), Expect = 4e-44 Identities = 115/385 (29%), Positives = 195/385 (50%), Gaps = 28/385 (7%) Query: 27 LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA 86 LD H L ++P ++ + +L LYL N+I + K + N L LS+ +N + LPA Sbjct: 174 LDLRHNKLREIPSVVYRLD-SLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPA 232 Query: 87 SIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLN 146 I L NL LDV+ N ++ P+ I NC +T ++ N + LPD L +L++L L Sbjct: 233 EIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLR 292 Query: 147 DAFLEFLPANFGRLTKLQILELRENQLKMLPKTM-NRLTQLERLDLGSNEFTEVPE---- 201 L +P + + + L+ L L N + LP+++ + L +L L L N F P Sbjct: 293 YNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPS 352 Query: 202 ---------------------VLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240 + + L + M N+LT +P G+ + L+++ N Sbjct: 353 QFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATN 412 Query: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 300 + + E +S +L+ L+LS+N L++LP +G+L+ + L ++EN+L LP+ I L Sbjct: 413 QLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKD 472 Query: 301 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSN-KLET 359 +++L + N++ LP IG LTNL N L LP EIG+ +N+ L+L+ N L + Sbjct: 473 LQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHS 532 Query: 360 LPEEMGDMQKLKVINLSDNRLKNLP 384 LP E+ KL ++++ + L +LP Sbjct: 533 LPFELALCSKLSIMSIENCPLSHLP 557 Score = 159 bits (403), Expect = 1e-38 Identities = 114/389 (29%), Positives = 182/389 (46%), Gaps = 50/389 (12%) Query: 93 NLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEF 152 N LD+SK I P +IK LT + N + LP L+NL L L++ L Sbjct: 101 NSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTS 160 Query: 153 LPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEF 212 LP + L KL++L+LR N+L+ +P + RL L L L N T V + ++ LS L Sbjct: 161 LPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSML 220 Query: 213 WMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI 272 + N++ +P IG L L LDV+ N +E + + I C + +L L N L LP+TI Sbjct: 221 SIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTI 280 Query: 273 GSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSI-------------- 318 G+L +++ L + N+L +P S+ ++EEL+ N + LP S+ Sbjct: 281 GNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLAR 340 Query: 319 -----------GQLTNLRTFAADH------------------------NYLQQLPPEIGS 343 Q + + + +H N L LP + G+ Sbjct: 341 NCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGT 400 Query: 344 WKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQS 403 W ++ L L +N+L +PE++ + L+V+ LS+N LK LP L++L + L +N+ Sbjct: 401 WTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKL 460 Query: 404 KPLIPLQKETDSETQKMVLTNYMFPQQPR 432 + L P + + QK+VLTN PR Sbjct: 461 ESL-PNEIAYLKDLQKLVLTNNQLTTLPR 488 Score = 154 bits (388), Expect = 7e-37 Identities = 106/327 (32%), Positives = 172/327 (52%), Gaps = 5/327 (1%) Query: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78 GE + TLD +H LE +PKEI + + L L N++ +LP + N SL +L L Sbjct: 235 GELCNLITLDVAHNQLEHLPKEIGNCTQ-ITNLDLQHNELLDLPDTIGNLSSLSRLGLRY 293 Query: 79 NDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKV-LTIVEASVNPISKLP-DGFSQ 136 N L+ +P S+A L EL++ N I PE++ + V L + + N P G SQ Sbjct: 294 NRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQ 353 Query: 137 LLNLTQLYLNDAFLEFLPAN-FGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNE 195 + L + + +P F R L L +++NQL LP T + L+L +N+ Sbjct: 354 FSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQ 413 Query: 196 FTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENL 255 T++PE + L L+ + N L +P +G+L++L LD+ +N +E + I+ ++L Sbjct: 414 LTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDL 473 Query: 256 QDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFN-EVEAL 314 Q L+L++N L LP IG L N+T L + EN L +LP+ IG L ++EEL + N + +L Sbjct: 474 QKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSL 533 Query: 315 PSSIGQLTNLRTFAADHNYLQQLPPEI 341 P + + L + ++ L LPP+I Sbjct: 534 PFELALCSKLSIMSIENCPLSHLPPQI 560 Score = 146 bits (368), Expect = 1e-34 Identities = 101/322 (31%), Positives = 162/322 (50%), Gaps = 10/322 (3%) Query: 120 VEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT 179 ++ S I LP +L LT+LYL L+ LPA G L L L L EN L LP + Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164 Query: 180 MNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSK 239 ++ L +L LDL N+ E+P V+ +L L ++ NR+T + I +L +L+ L + + Sbjct: 165 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 224 Query: 240 NNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLI 299 N I+ + I NL L ++ N L+ LP+ IG+ IT L + N+L+ LPD+IG L Sbjct: 225 NKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLS 284 Query: 300 SVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPE-IGSWKNITVLFLHSNKLE 358 S+ L +N + A+P S+ + + L ++N + LP + S + L L N + Sbjct: 285 SLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQ 344 Query: 359 TLPEEMGDMQKLKVI---NLSDNRLKNLPFS-FTKLQQLTAMWLSDNQSKPLIPLQKETD 414 P +G + I N+ NR+ +PF F++ + L+ + + DNQ L PL T Sbjct: 345 LYP--VGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSL-PLDFGTW 401 Query: 415 SETQKMVLTNYMFPQQPRTEDV 436 + ++ L + P EDV Sbjct: 402 TSMVELNLATNQLTKIP--EDV 421 >gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo sapiens] Length = 560 Score = 173 bits (439), Expect = 8e-43 Identities = 118/420 (28%), Positives = 206/420 (49%), Gaps = 12/420 (2%) Query: 23 TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-NCQSLHKLSLPDNDL 81 ++ +LD S+ + + +F L EL L ++E+P +F N L L L N L Sbjct: 95 SLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHL 154 Query: 82 TTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141 LP I N LRE+ + +N + FP+ + L I++ N I +P+ L L Sbjct: 155 KCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQ 214 Query: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPE 201 + Y+ L LPA+ + ++L +L+L N L +PK+ L ++ + L N +VP Sbjct: 215 KFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPR 274 Query: 202 VLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLS 261 ++ + + L ++ L + G L L +LD+S+N++ I +NL+ L L Sbjct: 275 LICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLD 334 Query: 262 SNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEEL----DCSFNEVEALPSS 317 N + QLP +GSL + L + N+ + P+ + L S+E+L D F ++ +P Sbjct: 335 DNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGF-KLTYVPEH 393 Query: 318 IGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSD 377 I +L +L+ ++N+L+ LP +GS N+ VL N L+ LP+ + Q LK + L D Sbjct: 394 IRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLED 453 Query: 378 NRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVM 437 N L +LP + L L + L DN P+ KE +E + + + + ++ R ++M Sbjct: 454 NLLTHLPENLDSLVNLKVLTLMDN---PMEEPPKEVCAEGNEAI---WKYLKENRNRNIM 507 Score = 165 bits (417), Expect = 3e-40 Identities = 114/382 (29%), Positives = 196/382 (51%), Gaps = 10/382 (2%) Query: 27 LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA 86 +D S+ SL +P EIFTF + LEE++L+ NQIEE+P+++ +++ L L N+L +L Sbjct: 30 IDASNQSLTAIPLEIFTFTE-LEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP 88 Query: 87 SIANLINLRELDVSKNGIQEFPENIKN----CKVLTIVEASVNPISKLPDGFSQLLNLTQ 142 ++ L +L LD+S N I + + + L + + + I + F L +L Sbjct: 89 ALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVI--FKNLHHLEL 146 Query: 143 LYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEV 202 L L L+ LP TKL+ + L+ NQ ++ P+ + L LE +DL N+ +PE Sbjct: 147 LGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEE 206 Query: 203 LEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSS 262 + L+GL++F+M +N L +P + QL+ LD+S N + + + + + ++ LS Sbjct: 207 IGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSG 266 Query: 263 NSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLT 322 N L+++P I ++ L + L L S L+++ LD S N + P I L Sbjct: 267 NRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALK 326 Query: 323 NLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE---MGDMQKLKVINLSDNR 379 NL D N + QLP E+GS + +L L N+ + PEE + ++KL + + Sbjct: 327 NLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFK 386 Query: 380 LKNLPFSFTKLQQLTAMWLSDN 401 L +P KLQ L +++ +N Sbjct: 387 LTYVPEHIRKLQSLKELYIENN 408 Score = 158 bits (400), Expect = 3e-38 Identities = 108/362 (29%), Positives = 182/362 (50%), Gaps = 7/362 (1%) Query: 34 LEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLIN 93 L+ +PKEI K L E+YL NQ E P++L +L + L +N + +P I +L Sbjct: 154 LKCLPKEIVNQTK-LREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTG 212 Query: 94 LRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFL 153 L++ ++ N + P ++ C L++++ S N + +P F++L +T++ L+ LE + Sbjct: 213 LQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKV 272 Query: 154 PANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFW 213 P R T L +L L L L + L L LDL N P + L L+ Sbjct: 273 PRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLG 332 Query: 214 MDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNS---LQQLPE 270 +D N++ +P +GSL +L L ++ N E + + +L+ L + + L +PE Sbjct: 333 LDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPE 392 Query: 271 TIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAAD 330 I L+++ L I+ N L YLP S+G + ++E LDC N ++ LP +I Q L+ + Sbjct: 393 HIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLE 452 Query: 331 HNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEM-GDMQKLKVINLSDNRLKNLPFSFTK 389 N L LP + S N+ VL L N +E P+E+ + + L +NR +N+ TK Sbjct: 453 DNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLKENRNRNI--MATK 510 Query: 390 LQ 391 +Q Sbjct: 511 IQ 512 >gi|238908508 leucine-rich repeat and death domain-containing protein [Homo sapiens] Length = 860 Score = 170 bits (431), Expect = 7e-42 Identities = 118/396 (29%), Positives = 188/396 (47%), Gaps = 27/396 (6%) Query: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83 + L + LE + +I F + L L LD N ++ +P+++ C L LSL DN LT Sbjct: 351 IKELQLADNKLEVISHKIENFRE-LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTE 409 Query: 84 LPASIANLINLRELDVSKNG-----------------------IQEFPENIKNCKVLTIV 120 LP I L NLR+L V++N I + P IKNC+ + + Sbjct: 410 LPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKI 469 Query: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180 E S N I P G L +L L +N ++ +P + +L LEL EN+L + + Sbjct: 470 ELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHF 529 Query: 181 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240 L L+ LDLG N+ ++P + + L + N+ P + +L+ L LD+S+N Sbjct: 530 CSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSEN 589 Query: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDE---NQLMYLPDSIGG 297 ++ + I + +Q L SSN P + L+++ L I + +L LP + Sbjct: 590 QLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSN 649 Query: 298 LISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKL 357 + ++ELD S N + +P +IG+L NL + A +N + LPP + S ++ L L N L Sbjct: 650 MTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNL 709 Query: 358 ETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQL 393 LP + ++ LK IN DN L P K +QL Sbjct: 710 TALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQL 745 Score = 154 bits (389), Expect = 5e-37 Identities = 108/399 (27%), Positives = 190/399 (47%), Gaps = 24/399 (6%) Query: 27 LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA 86 L+ SH + +PKEI + +L+ N IE P L +L LSL N L +P Sbjct: 216 LNVSHNHISHIPKEISQLGN-IRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPD 274 Query: 87 SIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLN 146 ++ +L LR L++ N + FP+ + L ++ + N IS LP +L NL L ++ Sbjct: 275 TLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMD 334 Query: 147 DAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQL 206 L FL +L K++ L+L +N+L+++ + +L L L N +PE + Sbjct: 335 HNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCC 394 Query: 207 SGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQ 266 + L+ + N+LT +P +I L L L V++NN+ + + IS N+ L S N + Sbjct: 395 AMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIIT 454 Query: 267 QLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG------- 319 +P I + + I +++ N++MY P + L S+ L + N + +P I Sbjct: 455 DVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLH 514 Query: 320 ----------------QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE 363 L NL+ N ++++P I + ++ VL L NK ET P E Sbjct: 515 LELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRE 574 Query: 364 MGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402 + ++ L+V++LS+N+L+ + L+ + + S NQ Sbjct: 575 LCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQ 613 Score = 150 bits (378), Expect = 1e-35 Identities = 119/424 (28%), Positives = 193/424 (45%), Gaps = 48/424 (11%) Query: 26 TLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELP-KQLFNCQSLHKLSLPDNDLTTL 84 T++ L++ PK+I K ++ LYLD NQI+ + L LSL +N L++L Sbjct: 145 TVNLEAKGLQEFPKDILKI-KYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSL 203 Query: 85 PASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLY 144 P+ I L NLR L+VS N I P+ I + + N I P L NL L Sbjct: 204 PSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILS 263 Query: 145 LNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLE 204 L L +P L L++L L NQL PK + L +L LDL N + +P+ + Sbjct: 264 LGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIR 323 Query: 205 QLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVE------------------ 246 +L L+ MD N+LTF+ I L ++ L ++ N +E++ Sbjct: 324 ELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNL 383 Query: 247 -----EGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSI------ 295 E IS C L+ L LS N L +LP+ I L N+ L ++ N ++ + D I Sbjct: 384 LKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNI 443 Query: 296 ------GGLIS-----------VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLP 338 G +I+ + +++ S+N++ P + L +L + + NY+ ++P Sbjct: 444 CSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIP 503 Query: 339 PEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWL 398 +I K + L L NKL E + LK ++L N++K +P S + + L + L Sbjct: 504 VDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLIL 563 Query: 399 SDNQ 402 N+ Sbjct: 564 CCNK 567 >gi|110825984 malignant fibrous histiocytoma amplified sequence 1 [Homo sapiens] Length = 1052 Score = 150 bits (380), Expect = 6e-36 Identities = 100/292 (34%), Positives = 146/292 (50%), Gaps = 2/292 (0%) Query: 1 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 60 + +R+ F RL P G +T LD SH L + E+ + + L +L L NQ+ Sbjct: 92 LVLRRNRFARLPPAVAELGHH--LTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPA 149 Query: 61 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120 LP QL L +L + N L LP S++ L LR LDV N + FP + L + Sbjct: 150 LPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEEL 209 Query: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180 + S N + LP+ S L L L+L+ A L LPA F L L+ L L N L+ LP Sbjct: 210 DVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQF 269 Query: 181 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240 + L +L+ L+L SN F E P L L+GL+E ++ N+LT +P I L +L L + N Sbjct: 270 SCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNN 329 Query: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLP 292 I + + I L++L+L N + LP+ G L + KI +N L+ P Sbjct: 330 RIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPP 381 Score = 137 bits (344), Expect = 9e-32 Identities = 106/340 (31%), Positives = 164/340 (48%), Gaps = 24/340 (7%) Query: 48 LEELYLDANQIEELPKQLFNCQ-SLHKLSLPDNDLTTLPASIANL-INLRELDVSKNGIQ 105 +E L L N +EE+P+ L + SL L L N LP ++A L +L ELDVS N Sbjct: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNR-- 122 Query: 106 EFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQI 165 LT + A V S L L +L L+ L LPA G L L+ Sbjct: 123 -----------LTALGAEV---------VSALRELRKLNLSHNQLPALPAQLGALAHLEE 162 Query: 166 LELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGF 225 L++ N+L LP +++ L++L LD+ N+ T P L QL L+E + +NRL +P Sbjct: 163 LDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPED 222 Query: 226 IGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDE 285 I +L+ L L +S + + G +L+ L+L +N LQ LP L+ + L + Sbjct: 223 ISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSS 282 Query: 286 NQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWK 345 N P ++ L +EEL S N++ ++PS I L L T D+N ++ LP I Sbjct: 283 NLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELT 342 Query: 346 NITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPF 385 + L L N++ LP+ G + ++ + + DN L P+ Sbjct: 343 GLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPY 382 Score = 134 bits (337), Expect = 6e-31 Identities = 95/320 (29%), Positives = 156/320 (48%), Gaps = 2/320 (0%) Query: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNC-QSLHKLSLPDNDLT 82 + L+ + LE+VP+ + + +L L L N+ LP + L +L + N LT Sbjct: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLT 124 Query: 83 TLPASIANLIN-LRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141 L A + + + LR+L++S N + P + L ++ S N ++ LPD S L L Sbjct: 125 ALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLR 184 Query: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPE 201 L ++ L P +L L+ L++ N+L+ LP+ ++ L L+ L L E +P Sbjct: 185 TLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPA 244 Query: 202 VLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLS 261 +L+ L+ +D N L +P L++L L++S N E + L++L LS Sbjct: 245 GFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLS 304 Query: 262 SNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQL 321 N L +P I L + TL +D N++ YLPDSI L +EEL N++ LP GQL Sbjct: 305 RNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQL 364 Query: 322 TNLRTFAADHNYLQQLPPEI 341 + + + N L Q P E+ Sbjct: 365 SRVGLWKIKDNPLIQPPYEV 384 Score = 129 bits (324), Expect = 2e-29 Identities = 102/337 (30%), Positives = 162/337 (48%), Gaps = 9/337 (2%) Query: 74 LSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCK-VLTIVEASVNPISKLPD 132 L P + LPA NL ++ L++ NG++E PE + + L ++ N ++LP Sbjct: 48 LESPASPQLVLPA---NLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPP 104 Query: 133 GFSQL-LNLTQLYLNDAFLEFLPANF-GRLTKLQILELRENQLKMLPKTMNRLTQLERLD 190 ++L +LT+L ++ L L A L +L+ L L NQL LP + L LE LD Sbjct: 105 AVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELD 164 Query: 191 LGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGIS 250 + N +P+ L LS L+ +D N+LT P + L L LDVS N + + E IS Sbjct: 165 VSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDIS 224 Query: 251 TCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNE 310 L+ L LS L LP L ++ +L +D N L LP L ++ L+ S N Sbjct: 225 ALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNL 284 Query: 311 VEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKL 370 E P+++ L L N L +P I + L+L +N++ LP+ + ++ L Sbjct: 285 FEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGL 344 Query: 371 KVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLI 407 + + L N++ LP F +L ++ + DN PLI Sbjct: 345 EELVLQGNQIAVLPDHFGQLSRVGLWKIKDN---PLI 378 >gi|21361633 leucine rich repeat containing 40 [Homo sapiens] Length = 602 Score = 149 bits (375), Expect = 2e-35 Identities = 118/377 (31%), Positives = 187/377 (49%), Gaps = 46/377 (12%) Query: 48 LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107 L +L + N+++ L L +L L + DN LT+LP++I L NL++L+VS N ++ Sbjct: 84 LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKIL 143 Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILE 167 PE I N + L + N ++ + +GF QL NL L L++ L +PA+F L+ L L Sbjct: 144 PEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLN 203 Query: 168 LRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIG 227 L N+LK LP +NR+ +L+ LD SN +P L + L+ ++ N+L F+P F Sbjct: 204 LSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEF-P 262 Query: 228 SLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQ 287 S L L V +N IEM+E E + L +I L + +N+ Sbjct: 263 SCSLLKELHVGENQIEMLE----------------------AEHLKHLNSILVLDLRDNK 300 Query: 288 LMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNI 347 L +PD I L S+E LD S N++ +LP S+G L +L+ A + N L+ + EI S Sbjct: 301 LKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQ 359 Query: 348 TVLFLHSNKLE---------------TLPEE----MGDMQKLKVINLSDNRLKNLP---F 385 VL +K++ TLP E + + LK+++ SD + +P F Sbjct: 360 EVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVF 419 Query: 386 SFTKLQQLTAMWLSDNQ 402 K +T++ S NQ Sbjct: 420 DAVKSNIVTSINFSKNQ 436 Score = 132 bits (332), Expect = 2e-30 Identities = 122/442 (27%), Positives = 208/442 (47%), Gaps = 39/442 (8%) Query: 20 EEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDN 79 E E + L+ SH L+ +P+EI T + L+ LYL N++ + + +L L L +N Sbjct: 126 ELENLQKLNVSHNKLKILPEEI-TNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNN 184 Query: 80 DLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLN 139 LTT+PAS ++L +L L++S N ++ P I K L ++ + N + +P + + + Sbjct: 185 HLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMES 244 Query: 140 LTQLYLNDAFLEFLPA-----------------------NFGRLTKLQILELRENQLKML 176 L LYL L FLP + L + +L+LR+N+LK + Sbjct: 245 LELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSV 304 Query: 177 PKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLD 236 P + L LERLDL +N+ + +P L L LK ++ N L I I S L Sbjct: 305 PDEIILLRSLERLDLSNNDISSLPYSLGNLH-LKFLALEGNPLRTIRREIISKGTQEVLK 363 Query: 237 VSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKI---DENQLMYLPD 293 ++ I+ ++G S E+ + ++ S E+ ++ I TLKI + Q +PD Sbjct: 364 YLRSKIK--DDGPSQSESATETAMTLPS-----ESRVNIHAIITLKILDYSDKQATLIPD 416 Query: 294 SIGGLIS---VEELDCSFNEVEALPSSIGQLTNLRTFA-ADHNYLQQLPPEIGSWKNITV 349 + + V ++ S N++ +P + +L + + N L + E+ + +T Sbjct: 417 EVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTF 476 Query: 350 LFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPL 409 L L +N L +LPEEM + +L+ INLS NR K LP ++ L + +S+NQ + P Sbjct: 477 LDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQ 536 Query: 410 QKETDSETQKMVLTNYMFPQQP 431 + + + L N Q P Sbjct: 537 KMKMMENLTTLDLQNNDLLQIP 558 Score = 125 bits (313), Expect = 3e-28 Identities = 94/328 (28%), Positives = 166/328 (50%), Gaps = 6/328 (1%) Query: 96 ELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPA 155 +L++S + E P+ + V EA+ N + + + +LT+L +++ L+ L Sbjct: 40 QLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSLTD 99 Query: 156 NFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMD 215 + L L +L++ +NQL LP + L L++L++ N+ +PE + L LK ++ Sbjct: 100 DLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQ 159 Query: 216 ANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSL 275 N LT I L L LD+S N++ V S+ +L L LSSN L+ LP I + Sbjct: 160 HNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRM 219 Query: 276 KNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQ 335 K + L + N L +P + G+ S+E L N++ LP + L+ N ++ Sbjct: 220 KRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP-EFPSCSLLKELHVGENQIE 278 Query: 336 QLPPE-IGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLT 394 L E + +I VL L NKL+++P+E+ ++ L+ ++LS+N + +LP+S L L Sbjct: 279 MLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLK 337 Query: 395 AMWLSDNQSKPLIPLQKETDSETQKMVL 422 + L N PL +++E S+ + VL Sbjct: 338 FLALEGN---PLRTIRREIISKGTQEVL 362 Score = 97.8 bits (242), Expect = 6e-20 Identities = 96/381 (25%), Positives = 175/381 (45%), Gaps = 28/381 (7%) Query: 23 TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82 ++ L+ S L+ +P EI K L+ L ++N +E +P +L +SL L L N L Sbjct: 198 SLVRLNLSSNELKSLPAEINRM-KRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLR 256 Query: 83 TLPASIANLINLRELDVSKNGIQEFP-ENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141 LP + L+EL V +N I+ E++K+ + +++ N + +PD L +L Sbjct: 257 FLP-EFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLE 315 Query: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERL--------DLGS 193 +L L++ + LP + G L L+ L L N L+ + + + E L D G Sbjct: 316 RLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGP 374 Query: 194 NEFTEVPEVLEQLSG-----------LKEFWMDANRLTFIPGFIGSLKQ---LTYLDVSK 239 ++ E L LK + T IP + + +T ++ SK Sbjct: 375 SQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSK 434 Query: 240 NNI-EMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGL 298 N + E+ + + E + D+ LS N L + + L+ +T L + N L LP+ + L Sbjct: 435 NQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESL 494 Query: 299 ISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPE-IGSWKNITVLFLHSNKL 357 + ++ ++ SFN + LP + ++ L T +N + + P+ + +N+T L L +N L Sbjct: 495 VRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDL 554 Query: 358 ETLPEEMGDMQKLKVINLSDN 378 +P E+G+ L+ + L N Sbjct: 555 LQIPPELGNCVNLRTLLLDGN 575 Score = 41.2 bits (95), Expect = 0.007 Identities = 26/106 (24%), Positives = 54/106 (50%), Gaps = 2/106 (1%) Query: 22 ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDL 81 + +T LD + L +P+E+ + + L+ + L N+ + LP+ L+ +L + + +N + Sbjct: 472 QKLTFLDLRNNFLNSLPEEMESLVR-LQTINLSFNRFKMLPEVLYRIFTLETILISNNQV 530 Query: 82 TTL-PASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNP 126 ++ P + + NL LD+ N + + P + NC L + NP Sbjct: 531 GSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNP 576 >gi|4503743 flightless I homolog [Homo sapiens] Length = 1269 Score = 139 bits (350), Expect = 2e-32 Identities = 102/340 (30%), Positives = 178/340 (52%), Gaps = 8/340 (2%) Query: 47 TLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQE 106 +L L L+ + LP++L Q L LS+ N+LTTL +++L +LR + N ++ Sbjct: 34 SLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKN 93 Query: 107 --FPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPAN-FGRLTKL 163 P++I L++++ S N +++ P N+ L L+ ++ +P F LT L Sbjct: 94 SGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDL 153 Query: 164 QILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP-EVLEQLSGLKEFWMDANRLT-- 220 L+L EN+L+ LP M RL L+ L L N L ++ L+ + + + T Sbjct: 154 LYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQS 213 Query: 221 FIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITT 280 +P + L L +D+S N++ V E + T +L+ L LSSN + +L I ++ T Sbjct: 214 NLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVET 273 Query: 281 LKIDENQLMYLPDSIGGLISVEELDCSFNEV--EALPSSIGQLTNLRTFAADHNYLQQLP 338 L + NQL LP +I L +++L + N++ + LPS IG+LTNL F A +N L+ +P Sbjct: 274 LNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVP 333 Query: 339 PEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDN 378 + + L L+ N L TLPE + + +++V+++ +N Sbjct: 334 ESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVREN 373 Score = 131 bits (329), Expect = 5e-30 Identities = 110/352 (31%), Positives = 168/352 (47%), Gaps = 17/352 (4%) Query: 27 LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT--L 84 L + L +P+E+ +K LE L + N + L +L + SL + N L + Sbjct: 38 LKLNRTGLCYLPEELAALQK-LEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGV 96 Query: 85 PASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDG-FSQLLNLTQL 143 P I L +L LD+S N + E P ++N K + ++ S N I +P+ F L +L L Sbjct: 97 PDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYL 156 Query: 144 YLNDAFLEFLPANFGRLTKLQILELREN-----QLKMLPKTMNRLTQLERLDLGSNEFTE 198 L++ LE LP RL LQ L L N QL+ LP +T L+ L L S + T+ Sbjct: 157 DLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPA----MTALQTLHLRSTQRTQ 212 Query: 199 --VPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQ 256 +P LE LS L + + N LT +P + +L L L++S N I + I +++ Sbjct: 213 SNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVE 272 Query: 257 DLLLSSNSLQQLPETIGSLKNITTLKIDENQLMY--LPDSIGGLISVEELDCSFNEVEAL 314 L LS N L LP I L + L ++ N+L + LP IG L ++EE + N +E + Sbjct: 273 TLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELV 332 Query: 315 PSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGD 366 P S+ + LR + N+L LP I I VL + N +P + D Sbjct: 333 PESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPAD 384 Score = 119 bits (297), Expect = 2e-26 Identities = 84/279 (30%), Positives = 140/279 (50%), Gaps = 11/279 (3%) Query: 22 ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-NCQSLHKLSLPDND 80 + ++ LD SH L + P+E+ K + L L N I+ +P QLF N L L L +N Sbjct: 104 DDLSVLDLSHNQLTECPRELEN-AKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENR 162 Query: 81 LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVE-----ASVNPISKLPDGFS 135 L +LP + L++L+ L ++ N + ++ +T ++ ++ S LP Sbjct: 163 LESLPPQMRRLVHLQTLVLNGNPLLH--AQLRQLPAMTALQTLHLRSTQRTQSNLPTSLE 220 Query: 136 QLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNE 195 L NL + L+ L +P L L+ L L NQ+ L +++ +E L+L N+ Sbjct: 221 GLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQ 280 Query: 196 FTEVPEVLEQLSGLKEFWMDANRLTF--IPGFIGSLKQLTYLDVSKNNIEMVEEGISTCE 253 T +P + +LS LK+ ++++N+L F +P IG L L + NN+E+V E + C Sbjct: 281 LTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCP 340 Query: 254 NLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLP 292 L+ L+L+ N L LPE I L I L + EN + +P Sbjct: 341 KLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379 Score = 115 bits (287), Expect = 4e-25 Identities = 106/375 (28%), Positives = 176/375 (46%), Gaps = 27/375 (7%) Query: 94 LRELDVSKNGIQE--FPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLE 151 +R +D+S N + FPEN+K L ++ + + LP+ + L L L ++ L Sbjct: 10 VRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLT 69 Query: 152 FLPANFGRLTKLQILELRENQLKM--LPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGL 209 L L L+ + R N LK +P + +L L LDL N+ TE P LE + Sbjct: 70 TLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNM 129 Query: 210 KEFWMDANRLTFIPG--FIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN---- 263 + N + IP FI +L L YLD+S+N +E + + +LQ L+L+ N Sbjct: 130 LVLNLSHNSIDTIPNQLFI-NLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLH 188 Query: 264 -SLQQLPETIGSLKNITTLKIDENQLMY--LPDSIGGLISVEELDCSFNEVEALPSSIGQ 320 L+QLP ++ + TL + Q LP S+ GL ++ ++D S N++ +P + Sbjct: 189 AQLRQLP----AMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYT 244 Query: 321 LTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRL 380 L +LR N + +L I W ++ L L N+L +LP + + KLK + L+ N+L Sbjct: 245 LPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKL 304 Query: 381 --KNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMF 438 LP KL L +++ N + L+P + +K+VL P E + F Sbjct: 305 DFDGLPSGIGKLTNLEE-FMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLP--EAIHF 361 Query: 439 ISDNESF----NPSL 449 +++ E NP+L Sbjct: 362 LTEIEVLDVRENPNL 376 >gi|65301141 PH domain and leucine rich repeat protein phosphatase-like [Homo sapiens] Length = 1323 Score = 124 bits (310), Expect = 8e-28 Identities = 114/376 (30%), Positives = 188/376 (50%), Gaps = 31/376 (8%) Query: 47 TLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQE 106 TL EL L N +LP Q+ N +L L L N LTTLP + NL L L +S N + Sbjct: 323 TLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQ 382 Query: 107 FPENIKNCKVLTIVEASVNPISKLPDGFSQLLN------LTQLYLNDAFLEFLPANFGRL 160 PE + +L V + N + L G +N L +L +E L N Sbjct: 383 IPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGN---- 438 Query: 161 TKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSG--LKEFWMDANR 218 + ++LR+N+L L ++ L LE+L G N+ E+ LSG L+ + +NR Sbjct: 439 KHITHVDLRDNRLTDL--DLSSLCSLEQLHCGRNQLREL-----TLSGFSLRTLYASSNR 491 Query: 219 LTFIPGF-IGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKN 277 LT + + + SL LT+LD+S+N +E V + + ++ L +S N L ++P I S + Sbjct: 492 LTAVNVYPVPSL--LTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLS 549 Query: 278 ITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSI-GQLTNLRTFAADHNYLQQ 336 + L + N + LP + I +E LD N + LP ++ + NLR A N L+ Sbjct: 550 LRKLMLGHNHVQNLPTLVEH-IPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLES 608 Query: 337 LPPEIGSWKNIT---VLFLHSNKL--ETLPEEMGDMQKLKVINLSDNRLKNLPFS-FTKL 390 LP ++++ +L+L +N L + +P +G + L++++L++N+L+ P S KL Sbjct: 609 LPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLH-LRILHLANNQLQTFPASKLNKL 667 Query: 391 QQLTAMWLSDNQSKPL 406 +QL + LS N+ K + Sbjct: 668 EQLEELNLSGNKLKTI 683 Score = 107 bits (268), Expect = 6e-23 Identities = 102/378 (26%), Positives = 170/378 (44%), Gaps = 32/378 (8%) Query: 53 LDANQIEELPKQLFNCQSLHKLSLPDNDLTT-LPASIANLIN---LRELDVSKNGIQEFP 108 L +EE+P+ LF Q + L+L N + P + L L+ L++S N + FP Sbjct: 256 LSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGLFP 315 Query: 109 ENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILEL 168 + LT + S N LP LLNL L L+ FL LP G L +L L + Sbjct: 316 ILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGI 375 Query: 169 RENQLKMLPKTMNRLTQLERLDLGSNEFTEVP-EVLEQLSGLKEFWMDANRL-TFIPGFI 226 N +P+ +LT L+R+ + N + VL +++ +K + N L T + + Sbjct: 376 SFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENL 435 Query: 227 GSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKN--------- 277 K +T++D+ N + ++ +S+ +L+ L N L++L + SL+ Sbjct: 436 EGNKHITHVDLRDNRLTDLD--LSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSNRLT 493 Query: 278 ----------ITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTF 327 +T L + N L +PD +E LD S+N + +P I +LR Sbjct: 494 AVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKL 553 Query: 328 AADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEM-GDMQKLKVINLSDNRLKNLPFS 386 HN++Q LP + + VL L N L LP+ + L+ +N S N L++LP + Sbjct: 554 MLGHNHVQNLPTLV-EHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSA 612 Query: 387 FT---KLQQLTAMWLSDN 401 T L L ++L++N Sbjct: 613 CTGEESLSMLQLLYLTNN 630 Score = 98.6 bits (244), Expect = 3e-20 Identities = 85/273 (31%), Positives = 135/273 (49%), Gaps = 12/273 (4%) Query: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83 +T LD S LE VP +K +E L + N + E+P ++ + SL KL L N + Sbjct: 504 LTFLDLSRNLLECVPDWACEAKK-IEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQN 562 Query: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKV-LTIVEASVNPISKLPD---GFSQLLN 139 LP + + I L LD+ N + P+ + + + L + AS N + LP G L Sbjct: 563 LPTLVEH-IPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSM 621 Query: 140 LTQLYLNDAFL--EFLPANFGRLTKLQILELRENQLKMLPKT-MNRLTQLERLDLGSNEF 196 L LYL + L + +P G L L+IL L NQL+ P + +N+L QLE L+L N+ Sbjct: 622 LQLLYLTNNLLTDQCIPVLVGHL-HLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKL 680 Query: 197 TEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQ 256 +P + L +N ++ P + L Q+ ++D+S N++ + + LQ Sbjct: 681 KTIPTTIANCKRLHTLVAHSNNISIFPEIL-QLPQIQFVDLSCNDLTEILIPEALPATLQ 739 Query: 257 DLLLSSNSLQQLP-ETIGSLKNITTLKIDENQL 288 DL L+ N+ L +T+ +ITTLKID+ L Sbjct: 740 DLDLTGNTNLVLEHKTLDIFSHITTLKIDQKPL 772 Score = 85.1 bits (209), Expect = 4e-16 Identities = 81/323 (25%), Positives = 143/323 (44%), Gaps = 43/323 (13%) Query: 117 LTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEF-LPANFGRLTK---LQILELRENQ 172 ++ V+ S + ++P+ ++T L L F++ P L K L+ L L N+ Sbjct: 251 ISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNK 310 Query: 173 LKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQL 232 L + P + ++ L L+L N F ++P + L L+ +D N LT +P +G+L+QL Sbjct: 311 LGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQL 370 Query: 233 TYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLP----------------------- 269 + L +S NN + E L ++++ N L+ L Sbjct: 371 SSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTM 430 Query: 270 --ETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTF 327 E + K+IT + + +N+L L + L S+E+L C N++ L S +LRT Sbjct: 431 VIENLEGNKHITHVDLRDNRLTDL--DLSSLCSLEQLHCGRNQLRELTLS---GFSLRTL 485 Query: 328 AADHNYLQQL----PPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNL 383 A N L + P + +T L L N LE +P+ + +K++V+++S N L + Sbjct: 486 YASSNRLTAVNVYPVPSL-----LTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEV 540 Query: 384 PFSFTKLQQLTAMWLSDNQSKPL 406 P L + L N + L Sbjct: 541 PVRILSSLSLRKLMLGHNHVQNL 563 Score = 72.8 bits (177), Expect = 2e-12 Identities = 73/295 (24%), Positives = 141/295 (47%), Gaps = 41/295 (13%) Query: 47 TLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA-SIANLINLRELDVSKNGIQ 105 +LE+L+ NQ+ EL F+ ++L+ S N LT + + +L+ LD+S+N ++ Sbjct: 461 SLEQLHCGRNQLRELTLSGFSLRTLYASS---NRLTAVNVYPVPSLLTF--LDLSRNLLE 515 Query: 106 EFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQI 165 P+ K + +++ S N ++++P L+L +L L ++ LP + L++ Sbjct: 516 CVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTLVEHIP-LEV 574 Query: 166 LELRENQLKMLPKTM-NRLTQLERLDLGSNEFTEVPEVL---EQLSGLKEFWMDANRLT- 220 L+L+ N L LP T+ ++ L L+ +N +P E LS L+ ++ N LT Sbjct: 575 LDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTD 634 Query: 221 -FIPGFIG-----------------------SLKQLTYLDVSKNNIEMVEEGISTCENLQ 256 IP +G L+QL L++S N ++ + I+ C+ L Sbjct: 635 QCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLH 694 Query: 257 DLLLSSNSLQQLPETIGSLKNITTLKIDENQL--MYLPDSIGGLISVEELDCSFN 309 L+ SN++ PE + L I + + N L + +P+++ ++++LD + N Sbjct: 695 TLVAHSNNISIFPEIL-QLPQIQFVDLSCNDLTEILIPEALPA--TLQDLDLTGN 746 >gi|197333692 leucine rich repeat containing 8 family, member B [Homo sapiens] Length = 803 Score = 123 bits (308), Expect = 1e-27 Identities = 103/355 (29%), Positives = 170/355 (47%), Gaps = 11/355 (3%) Query: 49 EELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNG-IQEF 107 +++ L + LP +F + LSL LP++++ L+NL+EL V + + + Sbjct: 420 DKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDH 479 Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFL-EFLPA----NFGRLTK 162 P + L I+ + K+P L NL +LYL+ L E L F L Sbjct: 480 PALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKN 539 Query: 163 LQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEV--LEQLSGLKEFWMDANRLT 220 L+ L L+ + ++ + L L++L L NE +++ + L+++ LK + + L Sbjct: 540 LRTLYLKSSLSRIPQVVTDLLPSLQKLSL-DNEGSKLVVLNNLKKMVNLKSLELISCDLE 598 Query: 221 FIPGFIGSLKQLTYLDVSKNNIEMVEEGIST--CENLQDLLLSSNSLQQLPETIGSLKNI 278 IP I SL L LD+ +NN++ VEE IS +NL L L N++ +P IG+L N+ Sbjct: 599 RIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNL 658 Query: 279 TTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLP 338 L +D N + LP + + LD S+N + +P I L+NL+ FA +N ++ LP Sbjct: 659 EQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLP 718 Query: 339 PEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQL 393 + K + L L N L L +G++ L + L N L+ LP Q L Sbjct: 719 DGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSL 773 Score = 108 bits (271), Expect = 3e-23 Identities = 90/294 (30%), Positives = 141/294 (47%), Gaps = 17/294 (5%) Query: 21 EETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQ--------SLH 72 EE + L + ++P+ +F K L+ELYL LP+QL Q +L Sbjct: 486 EENLKILRLKFTEMGKIPRWVFHL-KNLKELYLSGCV---LPEQLSTMQLEGFQDLKNLR 541 Query: 73 KLSLPDNDLTTLPASIANLI-NLRELDVSKNGIQEFP-ENIKNCKVLTIVEASVNPISKL 130 L L + L+ +P + +L+ +L++L + G + N+K L +E + ++ Sbjct: 542 TLYLKSS-LSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERI 600 Query: 131 PDGFSQLLNLTQLYLNDAFLEFLPA--NFGRLTKLQILELRENQLKMLPKTMNRLTQLER 188 P L NL +L L + L+ + +F L L L+L N + +P + L+ LE+ Sbjct: 601 PHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQ 660 Query: 189 LDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEG 248 L L N +P L + L + N LTFIP I L L Y V+ NNIEM+ +G Sbjct: 661 LSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDG 720 Query: 249 ISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVE 302 + C+ LQ LLL NSL L +G L N+T L++ N L LP + G S++ Sbjct: 721 LFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLK 774 Score = 99.8 bits (247), Expect = 2e-20 Identities = 86/346 (24%), Positives = 158/346 (45%), Gaps = 13/346 (3%) Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYL-NDAFLEFLPANFGRLTKLQIL 166 P+N+ + ++ + P KLP SQL+NL +L + + + + PA L+IL Sbjct: 433 PDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKIL 492 Query: 167 ELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLE-----QLSGLKEFWMDANRLTF 221 L+ ++ +P+ + L L+ L L E ++ L L+ ++ ++ L+ Sbjct: 493 RLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSS-LSR 551 Query: 222 IPGFIGSL-KQLTYLDVSKNNIEMVE-EGISTCENLQDLLLSSNSLQQLPETIGSLKNIT 279 IP + L L L + ++V + NL+ L L S L+++P +I SL N+ Sbjct: 552 IPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLH 611 Query: 280 TLKIDENQLMYLPDSIGGLISVEELDCS---FNEVEALPSSIGQLTNLRTFAADHNYLQQ 336 L + EN L + + I ++ L C N + +P+ IG L+NL + DHN ++ Sbjct: 612 ELDLRENNLKTVEEIIS-FQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIEN 670 Query: 337 LPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAM 396 LP ++ + L L N L +PEE+ + L+ +++N ++ LP + ++L + Sbjct: 671 LPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCL 730 Query: 397 WLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDN 442 L N L P E + T ++ NY+ P E + N Sbjct: 731 LLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRN 776 Score = 70.1 bits (170), Expect = 1e-11 Identities = 55/167 (32%), Positives = 72/167 (43%), Gaps = 24/167 (14%) Query: 22 ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDL 81 + ++ L H ++ +P +I LE+L LD N IE LP QLF C LH L L N L Sbjct: 633 QNLSCLKLWHNNIAYIPAQIGALSN-LEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHL 691 Query: 82 TTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141 T +P I L NL+ V+ N I+ LPDG Q L Sbjct: 692 TFIPEEIQYLSNLQYFAVTNNNIE-----------------------MLPDGLFQCKKLQ 728 Query: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLER 188 L L L L + G L+ L LEL N L+ LP + L+R Sbjct: 729 CLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKR 775 >gi|21245134 leucine rich repeat containing 8 family, member B [Homo sapiens] Length = 803 Score = 123 bits (308), Expect = 1e-27 Identities = 103/355 (29%), Positives = 170/355 (47%), Gaps = 11/355 (3%) Query: 49 EELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNG-IQEF 107 +++ L + LP +F + LSL LP++++ L+NL+EL V + + + Sbjct: 420 DKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDH 479 Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFL-EFLPA----NFGRLTK 162 P + L I+ + K+P L NL +LYL+ L E L F L Sbjct: 480 PALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKN 539 Query: 163 LQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEV--LEQLSGLKEFWMDANRLT 220 L+ L L+ + ++ + L L++L L NE +++ + L+++ LK + + L Sbjct: 540 LRTLYLKSSLSRIPQVVTDLLPSLQKLSL-DNEGSKLVVLNNLKKMVNLKSLELISCDLE 598 Query: 221 FIPGFIGSLKQLTYLDVSKNNIEMVEEGIST--CENLQDLLLSSNSLQQLPETIGSLKNI 278 IP I SL L LD+ +NN++ VEE IS +NL L L N++ +P IG+L N+ Sbjct: 599 RIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNL 658 Query: 279 TTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLP 338 L +D N + LP + + LD S+N + +P I L+NL+ FA +N ++ LP Sbjct: 659 EQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLP 718 Query: 339 PEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQL 393 + K + L L N L L +G++ L + L N L+ LP Q L Sbjct: 719 DGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSL 773 Score = 108 bits (271), Expect = 3e-23 Identities = 90/294 (30%), Positives = 141/294 (47%), Gaps = 17/294 (5%) Query: 21 EETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQ--------SLH 72 EE + L + ++P+ +F K L+ELYL LP+QL Q +L Sbjct: 486 EENLKILRLKFTEMGKIPRWVFHL-KNLKELYLSGCV---LPEQLSTMQLEGFQDLKNLR 541 Query: 73 KLSLPDNDLTTLPASIANLI-NLRELDVSKNGIQEFP-ENIKNCKVLTIVEASVNPISKL 130 L L + L+ +P + +L+ +L++L + G + N+K L +E + ++ Sbjct: 542 TLYLKSS-LSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERI 600 Query: 131 PDGFSQLLNLTQLYLNDAFLEFLPA--NFGRLTKLQILELRENQLKMLPKTMNRLTQLER 188 P L NL +L L + L+ + +F L L L+L N + +P + L+ LE+ Sbjct: 601 PHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQ 660 Query: 189 LDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEG 248 L L N +P L + L + N LTFIP I L L Y V+ NNIEM+ +G Sbjct: 661 LSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDG 720 Query: 249 ISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVE 302 + C+ LQ LLL NSL L +G L N+T L++ N L LP + G S++ Sbjct: 721 LFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLK 774 Score = 99.8 bits (247), Expect = 2e-20 Identities = 86/346 (24%), Positives = 158/346 (45%), Gaps = 13/346 (3%) Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYL-NDAFLEFLPANFGRLTKLQIL 166 P+N+ + ++ + P KLP SQL+NL +L + + + + PA L+IL Sbjct: 433 PDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKIL 492 Query: 167 ELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLE-----QLSGLKEFWMDANRLTF 221 L+ ++ +P+ + L L+ L L E ++ L L+ ++ ++ L+ Sbjct: 493 RLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSS-LSR 551 Query: 222 IPGFIGSL-KQLTYLDVSKNNIEMVE-EGISTCENLQDLLLSSNSLQQLPETIGSLKNIT 279 IP + L L L + ++V + NL+ L L S L+++P +I SL N+ Sbjct: 552 IPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLH 611 Query: 280 TLKIDENQLMYLPDSIGGLISVEELDCS---FNEVEALPSSIGQLTNLRTFAADHNYLQQ 336 L + EN L + + I ++ L C N + +P+ IG L+NL + DHN ++ Sbjct: 612 ELDLRENNLKTVEEIIS-FQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIEN 670 Query: 337 LPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAM 396 LP ++ + L L N L +PEE+ + L+ +++N ++ LP + ++L + Sbjct: 671 LPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCL 730 Query: 397 WLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDN 442 L N L P E + T ++ NY+ P E + N Sbjct: 731 LLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRN 776 Score = 70.1 bits (170), Expect = 1e-11 Identities = 55/167 (32%), Positives = 72/167 (43%), Gaps = 24/167 (14%) Query: 22 ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDL 81 + ++ L H ++ +P +I LE+L LD N IE LP QLF C LH L L N L Sbjct: 633 QNLSCLKLWHNNIAYIPAQIGALSN-LEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHL 691 Query: 82 TTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141 T +P I L NL+ V+ N I+ LPDG Q L Sbjct: 692 TFIPEEIQYLSNLQYFAVTNNNIE-----------------------MLPDGLFQCKKLQ 728 Query: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLER 188 L L L L + G L+ L LEL N L+ LP + L+R Sbjct: 729 CLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKR 775 >gi|40217803 leucine rich repeat containing 8 family, member E [Homo sapiens] Length = 796 Score = 120 bits (302), Expect = 6e-27 Identities = 98/353 (27%), Positives = 165/353 (46%), Gaps = 28/353 (7%) Query: 61 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQ-EFPENIKNCKVLTI 119 LP +F + L L T P ++ L++L+EL + + + F + L + Sbjct: 429 LPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSLQVFLRDHLKV 488 Query: 120 VEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPA-----NFGRLTKLQILELRENQLK 174 + + ++P L L +L+L F + L + L +L++L LR N K Sbjct: 489 MRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLKVLSLRSNAGK 548 Query: 175 MLPKTMNRLTQLERLDLGSNEFTEVP-EVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLT 233 + + L+RL L ++ V L++L+ L+E + A L IP + SL L Sbjct: 549 VPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGALQ 608 Query: 234 YLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPD 293 LD+ N++ +EE +S + + TL++ NQ+ Y+P+ Sbjct: 609 ELDLKDNHLRSIEEILS---------------------FQHCRKLVTLRLWHNQIAYVPE 647 Query: 294 SIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLH 353 + L S+E+L S+N++E LPS +G + LR HN L LPPE+G +N+ L L Sbjct: 648 HVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALS 707 Query: 354 SNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL 406 N LE LPEE+ +KL+ + L DN+L L L+ L+ + L N+ + L Sbjct: 708 YNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEAL 760 Score = 70.1 bits (170), Expect = 1e-11 Identities = 51/155 (32%), Positives = 76/155 (49%), Gaps = 2/155 (1%) Query: 39 KEIFTFE--KTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRE 96 +EI +F+ + L L L NQI +P+ + +SL +L L N L TLP+ + LR Sbjct: 621 EEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRL 680 Query: 97 LDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPAN 156 LDVS NG+ P + + L + S N + LP+ L L L D L L + Sbjct: 681 LDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPH 740 Query: 157 FGRLTKLQILELRENQLKMLPKTMNRLTQLERLDL 191 G L L LEL+ N+L+ LP+ + L++ L Sbjct: 741 VGALRALSRLELKGNRLEALPEELGNCGGLKKAGL 775 Score = 55.1 bits (131), Expect = 4e-07 Identities = 71/299 (23%), Positives = 119/299 (39%), Gaps = 61/299 (20%) Query: 166 LELRENQLKMLPKTMNRLTQLERLDLGS-------------------------------- 193 LEL L LP T+ L+++E L L + Sbjct: 419 LELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSL 478 Query: 194 ---------------NEFTEVPEVLEQLSGLKE------FWMDANRLTFIPGFIGSLKQL 232 E EVP + L GL+E F + R + + LKQL Sbjct: 479 QVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLES-LRELKQL 537 Query: 233 TYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLK---IDENQLM 289 L + N ++ +LQ L L ++ + + + SLK + L+ + L Sbjct: 538 KVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLV--ALNSLKKLAALRELELVACGLE 595 Query: 290 YLPDSIGGLISVEELDCSFNEVEALPS--SIGQLTNLRTFAADHNYLQQLPPEIGSWKNI 347 +P ++ L +++ELD N + ++ S L T HN + +P + +++ Sbjct: 596 RIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSL 655 Query: 348 TVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL 406 L+L NKLETLP ++G L+++++S N L +LP LQ L + LS N + L Sbjct: 656 EQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEAL 714 >gi|62241040 leucine rich repeat containing 8 family, member A [Homo sapiens] Length = 810 Score = 115 bits (287), Expect = 4e-25 Identities = 101/349 (28%), Positives = 168/349 (48%), Gaps = 17/349 (4%) Query: 49 EELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQ-EF 107 ++L L + +P +F+ L L L T+P SIA L L+EL + + E Sbjct: 426 DKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEA 485 Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYL-------NDAFLEFLPANFGRL 160 P + L + I ++P L L +L+L N+ ++ L Sbjct: 486 PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVI--DGLREL 543 Query: 161 TKLQILELRENQLKMLPKTMNRL-TQLERLDLGSNEFTE--VPEVLEQLSGLKEFWMDAN 217 +L++L L+ N L LP+ + + L++L + +NE T+ V L++++ L E + Sbjct: 544 KRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSI-NNEGTKLIVLNSLKKMANLTELELIRC 601 Query: 218 RLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGIST--CENLQDLLLSSNSLQQLPETIGSL 275 L IP I SL L +D+ NN++ +EE IS L L L N + +P IG+L Sbjct: 602 DLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNL 661 Query: 276 KNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQ 335 N+ L ++ N++ +P + + LD S N + LP+ IG L NL+ A N ++ Sbjct: 662 TNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIE 721 Query: 336 QLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP 384 LPPE+ + + L L +N L++LP +G++ L I L NRL+ LP Sbjct: 722 TLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770 Score = 110 bits (276), Expect = 7e-24 Identities = 88/300 (29%), Positives = 147/300 (49%), Gaps = 19/300 (6%) Query: 22 ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-----NCQSLHKLSL 76 E + L ++++P I++ KTLEEL+L N E + + + L L L Sbjct: 493 ENLRALHIKFTDIKEIPLWIYSL-KTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRL 551 Query: 77 PDNDLTTLPASIANL-INLRELDVSKNGIQEFPEN-IKNCKVLTIVEASVNPISKLPDGF 134 N L+ LP + ++ ++L++L ++ G + N +K LT +E + ++P Sbjct: 552 KSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSI 610 Query: 135 SQLLNLTQLYLNDAFLEFLPA--NFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLG 192 L NL ++ L D L+ + +F L +L L+L N + +P + LT LERL L Sbjct: 611 FSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLN 670 Query: 193 SNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTC 252 N+ ++P L L+ + N LTF+P IG L+ L L ++ N IE + + C Sbjct: 671 RNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQC 730 Query: 253 ENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIG--------GLISVEEL 304 L+ L L +N LQ LP +G L N+T +++ N+L LP +G GL+ E+L Sbjct: 731 RKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDL 790 Score = 89.4 bits (220), Expect = 2e-17 Identities = 94/327 (28%), Positives = 149/327 (45%), Gaps = 61/327 (18%) Query: 140 LTQLYLNDAFLEFLPANFGRLTK--LQILELRENQLKMLPKTMNRLTQLERLDLGSNEFT 197 L QL LN+ + L RLTK LEL L +P T+ L +LE L L Sbjct: 402 LRQLNLNNEWT--LDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDV 459 Query: 198 EVPEVLEQLSGLKEFWM-------DANRLTF-----------------IPGFIGSLKQLT 233 +P + QL+GLKE W+ +A L F IP +I SLK L Sbjct: 460 TIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLE 519 Query: 234 YLDVS-----KNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI---------------- 272 L ++ +NN +V +G+ + L+ L L SN L +LP+ + Sbjct: 520 ELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEG 578 Query: 273 ------GSLK---NITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG--QL 321 SLK N+T L++ L +P SI L +++E+D N ++ + I L Sbjct: 579 TKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHL 638 Query: 322 TNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLK 381 L +N++ +P +IG+ N+ L+L+ NK+E +P ++ +KL+ ++LS N L Sbjct: 639 HRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698 Query: 382 NLPFSFTKLQQLTAMWLSDNQSKPLIP 408 LP LQ L + ++ N+ + L P Sbjct: 699 FLPADIGLLQNLQNLAITANRIETLPP 725 Score = 88.6 bits (218), Expect = 4e-17 Identities = 58/157 (36%), Positives = 80/157 (50%), Gaps = 5/157 (3%) Query: 23 TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82 T L Y+H + +P +I LE LYL+ N+IE++P QLF C+ L L L N+LT Sbjct: 642 TCLKLWYNH--IAYIPIQIGNLTN-LERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698 Query: 83 TLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQ 142 LPA I L NL+ L ++ N I+ P + C+ L + N + LP +L NLTQ Sbjct: 699 FLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQ 758 Query: 143 LYLNDAFLEFLPANFGR--LTKLQILELRENQLKMLP 177 + L LE LP G L K L + E+ LP Sbjct: 759 IELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLP 795 >gi|187829877 leucine rich repeat containing 8 family, member A [Homo sapiens] Length = 810 Score = 115 bits (287), Expect = 4e-25 Identities = 101/349 (28%), Positives = 168/349 (48%), Gaps = 17/349 (4%) Query: 49 EELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQ-EF 107 ++L L + +P +F+ L L L T+P SIA L L+EL + + E Sbjct: 426 DKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEA 485 Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYL-------NDAFLEFLPANFGRL 160 P + L + I ++P L L +L+L N+ ++ L Sbjct: 486 PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVI--DGLREL 543 Query: 161 TKLQILELRENQLKMLPKTMNRL-TQLERLDLGSNEFTE--VPEVLEQLSGLKEFWMDAN 217 +L++L L+ N L LP+ + + L++L + +NE T+ V L++++ L E + Sbjct: 544 KRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSI-NNEGTKLIVLNSLKKMANLTELELIRC 601 Query: 218 RLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGIST--CENLQDLLLSSNSLQQLPETIGSL 275 L IP I SL L +D+ NN++ +EE IS L L L N + +P IG+L Sbjct: 602 DLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNL 661 Query: 276 KNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQ 335 N+ L ++ N++ +P + + LD S N + LP+ IG L NL+ A N ++ Sbjct: 662 TNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIE 721 Query: 336 QLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP 384 LPPE+ + + L L +N L++LP +G++ L I L NRL+ LP Sbjct: 722 TLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770 Score = 110 bits (276), Expect = 7e-24 Identities = 88/300 (29%), Positives = 147/300 (49%), Gaps = 19/300 (6%) Query: 22 ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-----NCQSLHKLSL 76 E + L ++++P I++ KTLEEL+L N E + + + L L L Sbjct: 493 ENLRALHIKFTDIKEIPLWIYSL-KTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRL 551 Query: 77 PDNDLTTLPASIANL-INLRELDVSKNGIQEFPEN-IKNCKVLTIVEASVNPISKLPDGF 134 N L+ LP + ++ ++L++L ++ G + N +K LT +E + ++P Sbjct: 552 KSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSI 610 Query: 135 SQLLNLTQLYLNDAFLEFLPA--NFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLG 192 L NL ++ L D L+ + +F L +L L+L N + +P + LT LERL L Sbjct: 611 FSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLN 670 Query: 193 SNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTC 252 N+ ++P L L+ + N LTF+P IG L+ L L ++ N IE + + C Sbjct: 671 RNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQC 730 Query: 253 ENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIG--------GLISVEEL 304 L+ L L +N LQ LP +G L N+T +++ N+L LP +G GL+ E+L Sbjct: 731 RKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDL 790 Score = 89.4 bits (220), Expect = 2e-17 Identities = 94/327 (28%), Positives = 149/327 (45%), Gaps = 61/327 (18%) Query: 140 LTQLYLNDAFLEFLPANFGRLTK--LQILELRENQLKMLPKTMNRLTQLERLDLGSNEFT 197 L QL LN+ + L RLTK LEL L +P T+ L +LE L L Sbjct: 402 LRQLNLNNEWT--LDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDV 459 Query: 198 EVPEVLEQLSGLKEFWM-------DANRLTF-----------------IPGFIGSLKQLT 233 +P + QL+GLKE W+ +A L F IP +I SLK L Sbjct: 460 TIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLE 519 Query: 234 YLDVS-----KNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI---------------- 272 L ++ +NN +V +G+ + L+ L L SN L +LP+ + Sbjct: 520 ELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEG 578 Query: 273 ------GSLK---NITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG--QL 321 SLK N+T L++ L +P SI L +++E+D N ++ + I L Sbjct: 579 TKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHL 638 Query: 322 TNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLK 381 L +N++ +P +IG+ N+ L+L+ NK+E +P ++ +KL+ ++LS N L Sbjct: 639 HRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698 Query: 382 NLPFSFTKLQQLTAMWLSDNQSKPLIP 408 LP LQ L + ++ N+ + L P Sbjct: 699 FLPADIGLLQNLQNLAITANRIETLPP 725 Score = 88.6 bits (218), Expect = 4e-17 Identities = 58/157 (36%), Positives = 80/157 (50%), Gaps = 5/157 (3%) Query: 23 TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82 T L Y+H + +P +I LE LYL+ N+IE++P QLF C+ L L L N+LT Sbjct: 642 TCLKLWYNH--IAYIPIQIGNLTN-LERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698 Query: 83 TLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQ 142 LPA I L NL+ L ++ N I+ P + C+ L + N + LP +L NLTQ Sbjct: 699 FLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQ 758 Query: 143 LYLNDAFLEFLPANFGR--LTKLQILELRENQLKMLP 177 + L LE LP G L K L + E+ LP Sbjct: 759 IELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLP 795 >gi|187829871 leucine rich repeat containing 8 family, member A [Homo sapiens] Length = 810 Score = 115 bits (287), Expect = 4e-25 Identities = 101/349 (28%), Positives = 168/349 (48%), Gaps = 17/349 (4%) Query: 49 EELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQ-EF 107 ++L L + +P +F+ L L L T+P SIA L L+EL + + E Sbjct: 426 DKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEA 485 Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYL-------NDAFLEFLPANFGRL 160 P + L + I ++P L L +L+L N+ ++ L Sbjct: 486 PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVI--DGLREL 543 Query: 161 TKLQILELRENQLKMLPKTMNRL-TQLERLDLGSNEFTE--VPEVLEQLSGLKEFWMDAN 217 +L++L L+ N L LP+ + + L++L + +NE T+ V L++++ L E + Sbjct: 544 KRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSI-NNEGTKLIVLNSLKKMANLTELELIRC 601 Query: 218 RLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGIST--CENLQDLLLSSNSLQQLPETIGSL 275 L IP I SL L +D+ NN++ +EE IS L L L N + +P IG+L Sbjct: 602 DLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNL 661 Query: 276 KNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQ 335 N+ L ++ N++ +P + + LD S N + LP+ IG L NL+ A N ++ Sbjct: 662 TNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIE 721 Query: 336 QLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP 384 LPPE+ + + L L +N L++LP +G++ L I L NRL+ LP Sbjct: 722 TLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770 Score = 110 bits (276), Expect = 7e-24 Identities = 88/300 (29%), Positives = 147/300 (49%), Gaps = 19/300 (6%) Query: 22 ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-----NCQSLHKLSL 76 E + L ++++P I++ KTLEEL+L N E + + + L L L Sbjct: 493 ENLRALHIKFTDIKEIPLWIYSL-KTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRL 551 Query: 77 PDNDLTTLPASIANL-INLRELDVSKNGIQEFPEN-IKNCKVLTIVEASVNPISKLPDGF 134 N L+ LP + ++ ++L++L ++ G + N +K LT +E + ++P Sbjct: 552 KSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSI 610 Query: 135 SQLLNLTQLYLNDAFLEFLPA--NFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLG 192 L NL ++ L D L+ + +F L +L L+L N + +P + LT LERL L Sbjct: 611 FSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLN 670 Query: 193 SNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTC 252 N+ ++P L L+ + N LTF+P IG L+ L L ++ N IE + + C Sbjct: 671 RNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQC 730 Query: 253 ENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIG--------GLISVEEL 304 L+ L L +N LQ LP +G L N+T +++ N+L LP +G GL+ E+L Sbjct: 731 RKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDL 790 Score = 89.4 bits (220), Expect = 2e-17 Identities = 94/327 (28%), Positives = 149/327 (45%), Gaps = 61/327 (18%) Query: 140 LTQLYLNDAFLEFLPANFGRLTK--LQILELRENQLKMLPKTMNRLTQLERLDLGSNEFT 197 L QL LN+ + L RLTK LEL L +P T+ L +LE L L Sbjct: 402 LRQLNLNNEWT--LDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDV 459 Query: 198 EVPEVLEQLSGLKEFWM-------DANRLTF-----------------IPGFIGSLKQLT 233 +P + QL+GLKE W+ +A L F IP +I SLK L Sbjct: 460 TIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLE 519 Query: 234 YLDVS-----KNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI---------------- 272 L ++ +NN +V +G+ + L+ L L SN L +LP+ + Sbjct: 520 ELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEG 578 Query: 273 ------GSLK---NITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG--QL 321 SLK N+T L++ L +P SI L +++E+D N ++ + I L Sbjct: 579 TKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHL 638 Query: 322 TNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLK 381 L +N++ +P +IG+ N+ L+L+ NK+E +P ++ +KL+ ++LS N L Sbjct: 639 HRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698 Query: 382 NLPFSFTKLQQLTAMWLSDNQSKPLIP 408 LP LQ L + ++ N+ + L P Sbjct: 699 FLPADIGLLQNLQNLAITANRIETLPP 725 Score = 88.6 bits (218), Expect = 4e-17 Identities = 58/157 (36%), Positives = 80/157 (50%), Gaps = 5/157 (3%) Query: 23 TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82 T L Y+H + +P +I LE LYL+ N+IE++P QLF C+ L L L N+LT Sbjct: 642 TCLKLWYNH--IAYIPIQIGNLTN-LERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698 Query: 83 TLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQ 142 LPA I L NL+ L ++ N I+ P + C+ L + N + LP +L NLTQ Sbjct: 699 FLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQ 758 Query: 143 LYLNDAFLEFLPANFGR--LTKLQILELRENQLKMLP 177 + L LE LP G L K L + E+ LP Sbjct: 759 IELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLP 795 >gi|21389431 leucine rich repeat containing 39 [Homo sapiens] Length = 335 Score = 114 bits (284), Expect = 8e-25 Identities = 68/218 (31%), Positives = 117/218 (53%), Gaps = 1/218 (0%) Query: 165 ILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPG 224 IL++ + + K LP ++ +L QL+ L ++PE + + L + N ++ IP Sbjct: 64 ILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPP 123 Query: 225 FIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN-SLQQLPETIGSLKNITTLKI 283 IG L +L L +S N I+ V + +S C +L+ L L+ N + LP+ + +L +T L + Sbjct: 124 GIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDL 183 Query: 284 DENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGS 343 N +P ++ + ++E LD N++E LP +I ++ NL T N + LP I + Sbjct: 184 SMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISN 243 Query: 344 WKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLK 381 KN+ L L +NKL+ +P M +M L+ +N DN LK Sbjct: 244 MKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLK 281 Score = 112 bits (281), Expect = 2e-24 Identities = 66/234 (28%), Positives = 124/234 (52%), Gaps = 3/234 (1%) Query: 189 LDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEG 248 L + E+ +P L +L+ L+E+ + L IP FIG + L LD+S+N I + G Sbjct: 65 LKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPG 124 Query: 249 ISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQ-LMYLPDSIGGLISVEELDCS 307 I LQ+L+LS N ++ +P+ + + ++ L++ N+ + LP + L+ + LD S Sbjct: 125 IGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLS 184 Query: 308 FNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDM 367 N+ +P ++ + L N L+QLP I +N+ L+L N++ LP+ + +M Sbjct: 185 MNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNM 244 Query: 368 QKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDN--QSKPLIPLQKETDSETQK 419 + L + LS+N+L+++P ++ L + DN + K +P + TD E ++ Sbjct: 245 KNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEGTDEEEER 298 Score = 92.0 bits (227), Expect = 3e-18 Identities = 73/265 (27%), Positives = 115/265 (43%), Gaps = 60/265 (22%) Query: 46 KTLEELYLDANQIEE----------LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLR 95 KTL L NQ++E +P+ + Q+L L L N ++ +P I L L+ Sbjct: 73 KTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQ 132 Query: 96 ELDVSKNGIQEFPENIKNCKVLTIVEASVN-PISKLPDGFSQLLNLTQLYLNDAFLEFLP 154 EL +S N I+ P+ + NC L +E +VN I LP S LL LT L Sbjct: 133 ELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHL----------- 181 Query: 155 ANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWM 214 +L N +P + + LE LD+GSN+ ++P+ +E++ L W+ Sbjct: 182 ------------DLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWL 229 Query: 215 DANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGS 274 N +T +P + IS +NL L+LS+N LQ +P + Sbjct: 230 QRNEITCLP-----------------------QTISNMKNLGTLVLSNNKLQDIPVCMEE 266 Query: 275 LKNITTLKIDENQL---MYLPDSIG 296 + N+ + +N L + LP S G Sbjct: 267 MANLRFVNFRDNPLKLKVSLPPSEG 291 Score = 77.4 bits (189), Expect = 8e-14 Identities = 51/181 (28%), Positives = 86/181 (47%), Gaps = 25/181 (13%) Query: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78 G + + LD S ++ ++P I + L+EL L N+I+ +PK+L NC SL KL L Sbjct: 103 GRFQNLIVLDLSRNTISEIPPGIGLLTR-LQELILSYNKIKTVPKELSNCASLEKLELAV 161 Query: 79 N------------------------DLTTLPASIANLINLRELDVSKNGIQEFPENIKNC 114 N D TT+P ++ N+ L LD+ N +++ P+ I+ Sbjct: 162 NRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERM 221 Query: 115 KVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLK 174 + L + N I+ LP S + NL L L++ L+ +P + L+ + R+N LK Sbjct: 222 QNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLK 281 Query: 175 M 175 + Sbjct: 282 L 282 Score = 61.2 bits (147), Expect = 6e-09 Identities = 41/139 (29%), Positives = 70/139 (50%), Gaps = 1/139 (0%) Query: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTN 323 SL +L E + LKI++ + LP S+ L ++E + +P IG+ N Sbjct: 48 SLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQN 107 Query: 324 LRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNR-LKN 382 L N + ++PP IG + L L NK++T+P+E+ + L+ + L+ NR + + Sbjct: 108 LIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICD 167 Query: 383 LPFSFTKLQQLTAMWLSDN 401 LP + L +LT + LS N Sbjct: 168 LPQELSNLLKLTHLDLSMN 186 >gi|19923729 leucine rich repeat containing 8 family, member C [Homo sapiens] Length = 803 Score = 112 bits (280), Expect = 2e-24 Identities = 95/366 (25%), Positives = 170/366 (46%), Gaps = 30/366 (8%) Query: 51 LYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPEN 110 L L + LP +F L L L +PA+IA L NL+EL + + ++ Sbjct: 426 LELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAA 485 Query: 111 IKNCKV-LTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPAN-----FGRLTKLQ 164 + K L ++ + + +LP L NL +LYL + + N L L+ Sbjct: 486 LSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLK 545 Query: 165 ILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEV--LEQLSGLKEFWMDANRLTFI 222 IL ++ N K+ ++ + L+++ + N+ T++ + L++++ L E + L I Sbjct: 546 ILSIKSNVSKIPQAVVDVSSHLQKMCI-HNDGTKLVMLNNLKKMTNLTELELVHCDLERI 604 Query: 223 PGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLK 282 P + SL L LD+ +NN++ +EE +S L+ +T LK Sbjct: 605 PHAVFSLLSLQELDLKENNLKSIEEIVS---------------------FQHLRKLTVLK 643 Query: 283 IDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIG 342 + N + Y+P+ I L S+E L S N++E LPS + +R +N ++ +PPEIG Sbjct: 644 LWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIG 703 Query: 343 SWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402 +++ + NK+E+LP+E+ +KLK + + N L L L L+ + + N Sbjct: 704 VLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNH 763 Query: 403 SKPLIP 408 + L P Sbjct: 764 FEILPP 769 Score = 111 bits (278), Expect = 4e-24 Identities = 82/292 (28%), Positives = 139/292 (47%), Gaps = 39/292 (13%) Query: 69 QSLHKLSLPDNDLTTLPASIANLINLREL--------DVSKNGIQEFPENIKNCKVLTIV 120 ++L LS+ +D+ LP + L NL EL D+S+N E ++K+ K+L+I Sbjct: 491 ENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIK 550 Query: 121 EASVNPISKLP-------------------------DGFSQLLNLTQLYLNDAFLEFLPA 155 + +SK+P + ++ NLT+L L LE +P Sbjct: 551 ----SNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPH 606 Query: 156 NFGRLTKLQILELRENQLKMLPKTMN--RLTQLERLDLGSNEFTEVPEVLEQLSGLKEFW 213 L LQ L+L+EN LK + + ++ L +L L L N T +PE +++L+ L+ Sbjct: 607 AVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLS 666 Query: 214 MDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIG 273 N++ +P + ++ YLD+S N+I + I ++LQ ++ N ++ LP+ + Sbjct: 667 FSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELY 726 Query: 274 SLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLR 325 K + TLKI +N L L IG L+ + LD N E LP +G L+ Sbjct: 727 FCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALK 778 Score = 66.2 bits (160), Expect = 2e-10 Identities = 47/166 (28%), Positives = 74/166 (44%), Gaps = 3/166 (1%) Query: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83 +T L H S+ +P+ I +LE L N+IE LP LF C + L L ND+ Sbjct: 639 LTVLKLWHNSITYIPEHIKKLT-SLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRF 697 Query: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143 +P I L +L+ ++ N ++ P+ + CK L ++ N +S L LL L+ L Sbjct: 698 IPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYL 757 Query: 144 YLNDAFLEFLPANFG--RLTKLQILELRENQLKMLPKTMNRLTQLE 187 + E LP G R K L + + + LP + + E Sbjct: 758 DVKGNHFEILPPELGDCRALKRAGLVVEDALFETLPSDVREQMKTE 803 Score = 63.5 bits (153), Expect = 1e-09 Identities = 50/192 (26%), Positives = 79/192 (41%), Gaps = 24/192 (12%) Query: 24 VTTLDYSHCSLEQVPKEIFTFE------------KTLEE------------LYLDANQIE 59 +T L+ HC LE++P +F+ K++EE L L N I Sbjct: 591 LTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSIT 650 Query: 60 ELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTI 119 +P+ + SL +LS N + LP+ + +R LD+S N I+ P I + L Sbjct: 651 YIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQY 710 Query: 120 VEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT 179 + N + LPD L L + L L G L L L+++ N ++LP Sbjct: 711 FSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPE 770 Query: 180 MNRLTQLERLDL 191 + L+R L Sbjct: 771 LGDCRALKRAGL 782 Score = 52.8 bits (125), Expect = 2e-06 Identities = 61/282 (21%), Positives = 126/282 (44%), Gaps = 42/282 (14%) Query: 167 ELRENQLKML-------PKTMNRLTQLE---RLDLGSNEFTEVPEVLEQLSGLKEFWMDA 216 E+ EN+LK L P + + Q RL+L + +P+ + +++ L+ ++ Sbjct: 394 EVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEI 453 Query: 217 NRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTC-ENLQDLLLSSNSLQQLPE----- 270 + IP I L L L + + ++++ +S ENL+ L + + +++LP Sbjct: 454 IKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGL 513 Query: 271 --------------------TIGSLKNITTLKI--DENQLMYLPDSIGGLISVEELDCSF 308 T+ SL+++ +LKI ++ + +P ++ + S + C Sbjct: 514 RNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIH 573 Query: 309 NEVEALP--SSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPE--EM 364 N+ L +++ ++TNL H L+++P + S ++ L L N L+++ E Sbjct: 574 NDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSF 633 Query: 365 GDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL 406 ++KL V+ L N + +P KL L + S N+ + L Sbjct: 634 QHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVL 675 >gi|61742786 leucine rich repeat and death domain containing protein isoform 3 [Homo sapiens] Length = 893 Score = 112 bits (279), Expect = 3e-24 Identities = 81/257 (31%), Positives = 130/257 (50%), Gaps = 24/257 (9%) Query: 131 PDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLD 190 P G QLL+L L+ L F RL+ + +L E L LP++++ L L Sbjct: 44 PGGCQQLLHLCV----QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSL---- 95 Query: 191 LGSNEFTEVPEVLEQLSGLKEFWMDA---NRLTFIPGFIGSLKQLTYLDVSKNNIEMVEE 247 VL+ G + + A LT +P + L L +LD+S N++E + Sbjct: 96 -----------VLK--GGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPA 142 Query: 248 GISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCS 307 + L LLLS N L +LPE +G+L +T L + N+L LP ++G L +++ LD S Sbjct: 143 CVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLS 202 Query: 308 FNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDM 367 N ++ LP IG L +L N LQ LP + +++ +L LHSN L ++P ++ + Sbjct: 203 QNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARL 262 Query: 368 QKLKVINLSDNRLKNLP 384 L ++L DN+L++LP Sbjct: 263 PLLTRLDLRDNQLRDLP 279 Score = 90.1 bits (222), Expect = 1e-17 Identities = 55/169 (32%), Positives = 85/169 (50%) Query: 173 LKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQL 232 L LP ++ L L LDL N +P + Q+ GL + N L+ +P +G+L L Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173 Query: 233 TYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLP 292 T+L V+ N ++ + + LQ L LS N L LP IG L ++ L + N+L LP Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233 Query: 293 DSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEI 341 S+ GL S+ L N + ++P+ + +L L N L+ LPPE+ Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282 Score = 82.8 bits (203), Expect = 2e-15 Identities = 54/162 (33%), Positives = 81/162 (50%) Query: 81 LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNL 140 LT LPA ++ L +L LD+S N ++ P + + L + S N +S+LP+ L L Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173 Query: 141 TQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP 200 T L + L+ LP G L+ LQ L+L +N L LP + L L L+L SN +P Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233 Query: 201 EVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNI 242 L L L+ + +N L +P + L LT LD+ N + Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 275 Score = 80.5 bits (197), Expect = 1e-14 Identities = 58/204 (28%), Positives = 103/204 (50%), Gaps = 13/204 (6%) Query: 213 WMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI 272 ++ NRL+ + + G +QL +L V + +++++ +D L +L QLP+++ Sbjct: 32 FLGGNRLS-LDLYPGGCQQLLHLCVQQP-LQLLQVEFLRLSTHEDPQLLEATLAQLPQSL 89 Query: 273 GSLKNITTLKIDENQ----------LMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLT 322 L+++ LK + + L LP + GL + LD SFN +E LP+ + Q+ Sbjct: 90 SCLRSLV-LKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMR 148 Query: 323 NLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKN 382 L HN L +LP +G+ +T L + N+L+TLP +G + L+ ++LS N L Sbjct: 149 GLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDT 208 Query: 383 LPFSFTKLQQLTAMWLSDNQSKPL 406 LP L L + L+ N+ + L Sbjct: 209 LPPEIGGLGSLLELNLASNRLQSL 232 Score = 76.3 bits (186), Expect = 2e-13 Identities = 53/169 (31%), Positives = 83/169 (49%) Query: 127 ISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQL 186 ++ LP G S L +L L L+ LE LPA ++ L L L N L LP+ + L L Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173 Query: 187 ERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVE 246 L + N +P L LS L+ + N L +P IG L L L+++ N ++ + Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233 Query: 247 EGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSI 295 ++ +L+ L+L SN L +P + L +T L + +NQL LP + Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282 Score = 73.2 bits (178), Expect = 2e-12 Identities = 54/166 (32%), Positives = 74/166 (44%) Query: 58 IEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVL 117 + LP L L L L N L TLPA + + L L +S N + E PE + L Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173 Query: 118 TIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLP 177 T + + N + LP L L +L L+ L+ LP G L L L L N+L+ LP Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233 Query: 178 KTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIP 223 ++ L L L L SN VP L +L L + N+L +P Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279 Score = 72.0 bits (175), Expect = 3e-12 Identities = 51/156 (32%), Positives = 74/156 (47%) Query: 48 LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107 L L L N +E LP + + L L L N L+ LP ++ L L L V+ N +Q Sbjct: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186 Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILE 167 P + L ++ S N + LP L +L +L L L+ LPA+ L L++L Sbjct: 187 PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLV 246 Query: 168 LRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203 L N L +P + RL L RLDL N+ ++P L Sbjct: 247 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282 Score = 52.8 bits (125), Expect = 2e-06 Identities = 35/113 (30%), Positives = 58/113 (51%), Gaps = 1/113 (0%) Query: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78 G +T L +H L+ +P + TL+ L L N ++ LP ++ SL +L+L Sbjct: 168 GALPALTFLTVTHNRLQTLPPALGALS-TLQRLDLSQNLLDTLPPEIGGLGSLLELNLAS 226 Query: 79 NDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLP 131 N L +LPAS+A L +LR L + N + P ++ +LT ++ N + LP Sbjct: 227 NRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279 Score = 48.5 bits (114), Expect = 4e-05 Identities = 32/93 (34%), Positives = 48/93 (51%), Gaps = 1/93 (1%) Query: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78 G T+ LD S L+ +P EI LE L L +N+++ LP L +SL L L Sbjct: 191 GALSTLQRLDLSQNLLDTLPPEIGGLGSLLE-LNLASNRLQSLPASLAGLRSLRLLVLHS 249 Query: 79 NDLTTLPASIANLINLRELDVSKNGIQEFPENI 111 N L ++PA +A L L LD+ N +++ P + Sbjct: 250 NLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282 >gi|61742784 leucine rich repeat and death domain containing protein isoform 1 [Homo sapiens] Length = 910 Score = 112 bits (279), Expect = 3e-24 Identities = 81/257 (31%), Positives = 130/257 (50%), Gaps = 24/257 (9%) Query: 131 PDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLD 190 P G QLL+L L+ L F RL+ + +L E L LP++++ L L Sbjct: 44 PGGCQQLLHLCV----QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSL---- 95 Query: 191 LGSNEFTEVPEVLEQLSGLKEFWMDA---NRLTFIPGFIGSLKQLTYLDVSKNNIEMVEE 247 VL+ G + + A LT +P + L L +LD+S N++E + Sbjct: 96 -----------VLK--GGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPA 142 Query: 248 GISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCS 307 + L LLLS N L +LPE +G+L +T L + N+L LP ++G L +++ LD S Sbjct: 143 CVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLS 202 Query: 308 FNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDM 367 N ++ LP IG L +L N LQ LP + +++ +L LHSN L ++P ++ + Sbjct: 203 QNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARL 262 Query: 368 QKLKVINLSDNRLKNLP 384 L ++L DN+L++LP Sbjct: 263 PLLTRLDLRDNQLRDLP 279 Score = 90.1 bits (222), Expect = 1e-17 Identities = 55/169 (32%), Positives = 85/169 (50%) Query: 173 LKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQL 232 L LP ++ L L LDL N +P + Q+ GL + N L+ +P +G+L L Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173 Query: 233 TYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLP 292 T+L V+ N ++ + + LQ L LS N L LP IG L ++ L + N+L LP Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233 Query: 293 DSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEI 341 S+ GL S+ L N + ++P+ + +L L N L+ LPPE+ Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282 Score = 82.8 bits (203), Expect = 2e-15 Identities = 54/162 (33%), Positives = 81/162 (50%) Query: 81 LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNL 140 LT LPA ++ L +L LD+S N ++ P + + L + S N +S+LP+ L L Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173 Query: 141 TQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP 200 T L + L+ LP G L+ LQ L+L +N L LP + L L L+L SN +P Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233 Query: 201 EVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNI 242 L L L+ + +N L +P + L LT LD+ N + Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 275 Score = 80.5 bits (197), Expect = 1e-14 Identities = 58/204 (28%), Positives = 103/204 (50%), Gaps = 13/204 (6%) Query: 213 WMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI 272 ++ NRL+ + + G +QL +L V + +++++ +D L +L QLP+++ Sbjct: 32 FLGGNRLS-LDLYPGGCQQLLHLCVQQP-LQLLQVEFLRLSTHEDPQLLEATLAQLPQSL 89 Query: 273 GSLKNITTLKIDENQ----------LMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLT 322 L+++ LK + + L LP + GL + LD SFN +E LP+ + Q+ Sbjct: 90 SCLRSLV-LKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMR 148 Query: 323 NLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKN 382 L HN L +LP +G+ +T L + N+L+TLP +G + L+ ++LS N L Sbjct: 149 GLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDT 208 Query: 383 LPFSFTKLQQLTAMWLSDNQSKPL 406 LP L L + L+ N+ + L Sbjct: 209 LPPEIGGLGSLLELNLASNRLQSL 232 Score = 76.3 bits (186), Expect = 2e-13 Identities = 53/169 (31%), Positives = 83/169 (49%) Query: 127 ISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQL 186 ++ LP G S L +L L L+ LE LPA ++ L L L N L LP+ + L L Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173 Query: 187 ERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVE 246 L + N +P L LS L+ + N L +P IG L L L+++ N ++ + Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233 Query: 247 EGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSI 295 ++ +L+ L+L SN L +P + L +T L + +NQL LP + Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282 Score = 73.2 bits (178), Expect = 2e-12 Identities = 54/166 (32%), Positives = 74/166 (44%) Query: 58 IEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVL 117 + LP L L L L N L TLPA + + L L +S N + E PE + L Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173 Query: 118 TIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLP 177 T + + N + LP L L +L L+ L+ LP G L L L L N+L+ LP Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233 Query: 178 KTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIP 223 ++ L L L L SN VP L +L L + N+L +P Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279 Score = 72.0 bits (175), Expect = 3e-12 Identities = 51/156 (32%), Positives = 74/156 (47%) Query: 48 LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107 L L L N +E LP + + L L L N L+ LP ++ L L L V+ N +Q Sbjct: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186 Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILE 167 P + L ++ S N + LP L +L +L L L+ LPA+ L L++L Sbjct: 187 PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLV 246 Query: 168 LRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203 L N L +P + RL L RLDL N+ ++P L Sbjct: 247 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282 Score = 52.8 bits (125), Expect = 2e-06 Identities = 35/113 (30%), Positives = 58/113 (51%), Gaps = 1/113 (0%) Query: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78 G +T L +H L+ +P + TL+ L L N ++ LP ++ SL +L+L Sbjct: 168 GALPALTFLTVTHNRLQTLPPALGALS-TLQRLDLSQNLLDTLPPEIGGLGSLLELNLAS 226 Query: 79 NDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLP 131 N L +LPAS+A L +LR L + N + P ++ +LT ++ N + LP Sbjct: 227 NRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279 Score = 48.5 bits (114), Expect = 4e-05 Identities = 32/93 (34%), Positives = 48/93 (51%), Gaps = 1/93 (1%) Query: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78 G T+ LD S L+ +P EI LE L L +N+++ LP L +SL L L Sbjct: 191 GALSTLQRLDLSQNLLDTLPPEIGGLGSLLE-LNLASNRLQSLPASLAGLRSLRLLVLHS 249 Query: 79 NDLTTLPASIANLINLRELDVSKNGIQEFPENI 111 N L ++PA +A L L LD+ N +++ P + Sbjct: 250 NLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282 >gi|205277468 leucine rich repeat containing 15 isoform a [Homo sapiens] Length = 587 Score = 111 bits (278), Expect = 4e-24 Identities = 113/404 (27%), Positives = 183/404 (45%), Gaps = 49/404 (12%) Query: 66 FNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF-PENIKNCKVLTIVEASV 124 +N SL L+ +L P N+ L L + KN + P +N L + + Sbjct: 59 WNAMSLQILNTHITELNESP--FLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLAN 116 Query: 125 NPISKLPDGFSQLLNLTQLYL--NDAFLEFLPANFGRLTKLQILELRENQLKMLPK-TMN 181 N + LP G Q L+ + L ++ L+ PA+F + + L+ L+L N L+ +P + Sbjct: 117 NKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFD 176 Query: 182 RLTQLERLDLGSNEFTEV-PEVLEQLSGLKEFWMDANRLTFIP-GFIGSLKQLTYLDVSK 239 L L +L+LG N T + P V + L L+ + NRLT IP G L L L + + Sbjct: 177 HLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQ 236 Query: 240 NNIEMVEEGI-STCENLQDLLLSSNSLQQLPETI-------------------------G 273 N I ++ G+ NLQ L LS+N + QLP +I G Sbjct: 237 NQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFG 296 Query: 274 SLKNITTLKIDENQLMYLPDSI-GGLISVEELDCSFNEVEAL-PSSIGQLTNLRTFAADH 331 + N+ L + +N + LPD++ L ++ L S N++ + P + LT LR + Sbjct: 297 PMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHT 356 Query: 332 NYLQQLPPEI-GSWKNITVLFLHSNKLETLPEEM-GDMQKLKVINLSDNRLKNLPFS-FT 388 N LQ L + N+ + L +N+L LP + ++ L I L +N+L+NLP F Sbjct: 357 NALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFD 416 Query: 389 KLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPR 432 L +L + L DN P + ++D + L N++ QPR Sbjct: 417 HLGKLCELRLYDN------PWRCDSDI----LPLRNWLLLNQPR 450 Score = 110 bits (275), Expect = 9e-24 Identities = 98/342 (28%), Positives = 167/342 (48%), Gaps = 14/342 (4%) Query: 51 LYLDANQIEELPKQLF-NCQSLHKLSLPDNDLTTLPASI-ANLINLRELDVSKNGIQEF- 107 L ++ N++ + F N SL LSL +N L LP + L +L L +S N + + Sbjct: 88 LRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQ 147 Query: 108 PENIKNCKVLTIVEASVNPISKLPDG-FSQLLNLTQLYL-NDAFLEFLPANFGRLTKLQI 165 P + C L ++ N + +PDG F L+ LT+L L ++ P F L LQ+ Sbjct: 148 PAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQV 207 Query: 166 LELRENQLKMLPK-TMNRLTQLERLDLGSNEFTEV-PEVLEQLSGLKEFWMDANRLTFI- 222 L L EN+L +P T + L L+ L L N+ + P + L+ ++ N ++ + Sbjct: 208 LRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLP 267 Query: 223 PGFIGSLKQLTYLDVSKNNIEMVEEGI-STCENLQDLLLSSNSLQQLPETI-GSLKNITT 280 P L QL L + N+++ + GI NL++L L N + LP+ + +L+ + Sbjct: 268 PSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQV 327 Query: 281 LKIDENQLMYL-PDSIGGLISVEELDCSFNEVEALPSSI-GQLTNLRTFAADHNYLQQLP 338 L + NQ+ ++ P + GL + EL N ++ L ++ L NL+ + +N L+QLP Sbjct: 328 LILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLP 387 Query: 339 PEI-GSWKNITVLFLHSNKLETLPEEMGD-MQKLKVINLSDN 378 I + + + L +N+LE LP + D + KL + L DN Sbjct: 388 GNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 429 Score = 72.0 bits (175), Expect = 3e-12 Identities = 67/222 (30%), Positives = 99/222 (44%), Gaps = 28/222 (12%) Query: 34 LEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-NCQSLHKLSLPDNDLTTLPASI-ANL 91 L +P F L+EL L NQI L LF N +L +L L +N ++ LP SI L Sbjct: 215 LTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQL 274 Query: 92 INLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLE 151 L L + N ++E I F + NL +L+L D + Sbjct: 275 PQLNRLTLFGNSLKELSLGI----------------------FGPMPNLRELWLYDNHIS 312 Query: 152 FLPAN-FGRLTKLQILELRENQLKML-PKTMNRLTQLERLDLGSNEFTEVP-EVLEQLSG 208 LP N F L +LQ+L L NQ+ + P N LT+L L L +N ++ V L+ Sbjct: 313 SLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLAN 372 Query: 209 LKEFWMDANRLTFIPGFI-GSLKQLTYLDVSKNNIEMVEEGI 249 L+ + NRL +PG I ++ L + + N +E + GI Sbjct: 373 LQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGI 414 Score = 52.4 bits (124), Expect = 3e-06 Identities = 44/148 (29%), Positives = 65/148 (43%), Gaps = 25/148 (16%) Query: 33 SLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-NCQSLHKLSLPDNDLTTL-PASIAN 90 SL+++ IF L EL+L N I LP +F N + L L L N ++ + P + Sbjct: 286 SLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNG 345 Query: 91 LINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFL 150 L LREL + N +Q+ N+ F L NL + L + L Sbjct: 346 LTELRELSLHTNALQDLDGNV----------------------FRMLANLQNISLQNNRL 383 Query: 151 EFLPAN-FGRLTKLQILELRENQLKMLP 177 LP N F + L ++L+ NQL+ LP Sbjct: 384 RQLPGNIFANVNGLMAIQLQNNQLENLP 411 >gi|18677767 leucine rich repeat containing 15 isoform b [Homo sapiens] Length = 581 Score = 111 bits (278), Expect = 4e-24 Identities = 113/404 (27%), Positives = 183/404 (45%), Gaps = 49/404 (12%) Query: 66 FNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF-PENIKNCKVLTIVEASV 124 +N SL L+ +L P N+ L L + KN + P +N L + + Sbjct: 53 WNAMSLQILNTHITELNESP--FLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLAN 110 Query: 125 NPISKLPDGFSQLLNLTQLYL--NDAFLEFLPANFGRLTKLQILELRENQLKMLPK-TMN 181 N + LP G Q L+ + L ++ L+ PA+F + + L+ L+L N L+ +P + Sbjct: 111 NKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFD 170 Query: 182 RLTQLERLDLGSNEFTEV-PEVLEQLSGLKEFWMDANRLTFIP-GFIGSLKQLTYLDVSK 239 L L +L+LG N T + P V + L L+ + NRLT IP G L L L + + Sbjct: 171 HLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQ 230 Query: 240 NNIEMVEEGI-STCENLQDLLLSSNSLQQLPETI-------------------------G 273 N I ++ G+ NLQ L LS+N + QLP +I G Sbjct: 231 NQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFG 290 Query: 274 SLKNITTLKIDENQLMYLPDSI-GGLISVEELDCSFNEVEAL-PSSIGQLTNLRTFAADH 331 + N+ L + +N + LPD++ L ++ L S N++ + P + LT LR + Sbjct: 291 PMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHT 350 Query: 332 NYLQQLPPEI-GSWKNITVLFLHSNKLETLPEEM-GDMQKLKVINLSDNRLKNLPFS-FT 388 N LQ L + N+ + L +N+L LP + ++ L I L +N+L+NLP F Sbjct: 351 NALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFD 410 Query: 389 KLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPR 432 L +L + L DN P + ++D + L N++ QPR Sbjct: 411 HLGKLCELRLYDN------PWRCDSDI----LPLRNWLLLNQPR 444 Score = 110 bits (275), Expect = 9e-24 Identities = 98/342 (28%), Positives = 167/342 (48%), Gaps = 14/342 (4%) Query: 51 LYLDANQIEELPKQLF-NCQSLHKLSLPDNDLTTLPASI-ANLINLRELDVSKNGIQEF- 107 L ++ N++ + F N SL LSL +N L LP + L +L L +S N + + Sbjct: 82 LRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQ 141 Query: 108 PENIKNCKVLTIVEASVNPISKLPDG-FSQLLNLTQLYL-NDAFLEFLPANFGRLTKLQI 165 P + C L ++ N + +PDG F L+ LT+L L ++ P F L LQ+ Sbjct: 142 PAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQV 201 Query: 166 LELRENQLKMLPK-TMNRLTQLERLDLGSNEFTEV-PEVLEQLSGLKEFWMDANRLTFI- 222 L L EN+L +P T + L L+ L L N+ + P + L+ ++ N ++ + Sbjct: 202 LRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLP 261 Query: 223 PGFIGSLKQLTYLDVSKNNIEMVEEGI-STCENLQDLLLSSNSLQQLPETI-GSLKNITT 280 P L QL L + N+++ + GI NL++L L N + LP+ + +L+ + Sbjct: 262 PSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQV 321 Query: 281 LKIDENQLMYL-PDSIGGLISVEELDCSFNEVEALPSSI-GQLTNLRTFAADHNYLQQLP 338 L + NQ+ ++ P + GL + EL N ++ L ++ L NL+ + +N L+QLP Sbjct: 322 LILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLP 381 Query: 339 PEI-GSWKNITVLFLHSNKLETLPEEMGD-MQKLKVINLSDN 378 I + + + L +N+LE LP + D + KL + L DN Sbjct: 382 GNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 423 Score = 72.0 bits (175), Expect = 3e-12 Identities = 67/222 (30%), Positives = 99/222 (44%), Gaps = 28/222 (12%) Query: 34 LEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-NCQSLHKLSLPDNDLTTLPASI-ANL 91 L +P F L+EL L NQI L LF N +L +L L +N ++ LP SI L Sbjct: 209 LTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQL 268 Query: 92 INLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLE 151 L L + N ++E I F + NL +L+L D + Sbjct: 269 PQLNRLTLFGNSLKELSLGI----------------------FGPMPNLRELWLYDNHIS 306 Query: 152 FLPAN-FGRLTKLQILELRENQLKML-PKTMNRLTQLERLDLGSNEFTEVP-EVLEQLSG 208 LP N F L +LQ+L L NQ+ + P N LT+L L L +N ++ V L+ Sbjct: 307 SLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLAN 366 Query: 209 LKEFWMDANRLTFIPGFI-GSLKQLTYLDVSKNNIEMVEEGI 249 L+ + NRL +PG I ++ L + + N +E + GI Sbjct: 367 LQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGI 408 Score = 52.4 bits (124), Expect = 3e-06 Identities = 44/148 (29%), Positives = 65/148 (43%), Gaps = 25/148 (16%) Query: 33 SLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-NCQSLHKLSLPDNDLTTL-PASIAN 90 SL+++ IF L EL+L N I LP +F N + L L L N ++ + P + Sbjct: 280 SLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNG 339 Query: 91 LINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFL 150 L LREL + N +Q+ N+ F L NL + L + L Sbjct: 340 LTELRELSLHTNALQDLDGNV----------------------FRMLANLQNISLQNNRL 377 Query: 151 EFLPAN-FGRLTKLQILELRENQLKMLP 177 LP N F + L ++L+ NQL+ LP Sbjct: 378 RQLPGNIFANVNGLMAIQLQNNQLENLP 405 >gi|197333706 leucine rich repeat containing 8 family, member D [Homo sapiens] Length = 858 Score = 110 bits (276), Expect = 7e-24 Identities = 87/323 (26%), Positives = 153/323 (47%), Gaps = 31/323 (9%) Query: 71 LHKLSLPDNDLTTLPASIANLINLRELDV-----SKNGIQEFPENIKNCKVLTIVEASVN 125 L L + D+ +PA + L NLREL + S+N E+++ + L I+ N Sbjct: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598 Query: 126 PISKLPDGFSQLL-NLTQLYLNDAFLEFLPAN-FGRLTKLQILELRENQLKMLPKTMNRL 183 ++K+P + + +LT+L +++ + L N ++ + LEL+ +L+ +P + L Sbjct: 599 -LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSL 657 Query: 184 TQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIE 243 + L+ LDL SN + E++ LK+LT L + N I Sbjct: 658 SNLQELDLKSNNIRTIEEIIS---------------------FQHLKRLTCLKLWHNKIV 696 Query: 244 MVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEE 303 + I+ +NL+ L S+N L+ LP + SL+ + L + N + +P IG L +++ Sbjct: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQH 756 Query: 304 LDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE 363 L + N+V+ LP + + LRT N + LP ++G +T L L N L+ LP + Sbjct: 757 LHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQ 816 Query: 364 MGDMQKLKVINL--SDNRLKNLP 384 +G + LK L D+ LP Sbjct: 817 LGQCRMLKKSGLVVEDHLFDTLP 839 Score = 110 bits (274), Expect = 1e-23 Identities = 100/380 (26%), Positives = 175/380 (46%), Gaps = 46/380 (12%) Query: 42 FTFEKTLEELYLDANQIEEL--------PKQLFNCQSLHKLSLPDNDLTTLPASIANLIN 93 +TFEK + + +A +EL P +F+ L L L +PA I+ + N Sbjct: 455 WTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTN 514 Query: 94 LRELDVSKNGIQEFPENIKNCKV------LTIVEASVNPISKLPDGFSQLLNLTQLYLND 147 L+EL + P ++ L + ++++P L NL +LYL Sbjct: 515 LQELHLC-----HCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYL-- 567 Query: 148 AFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP----EVL 203 G L EN + +++ L L+ L + SN T+VP +V Sbjct: 568 ---------IGNLNS-------ENNKMIGLESLRELRHLKILHVKSN-LTKVPSNITDVA 610 Query: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263 L+ L D +L + + + + L++ +E + I + NLQ+L L SN Sbjct: 611 PHLTKLV-IHNDGTKLLVLNS-LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSN 668 Query: 264 SLQQLPETIG--SLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQL 321 +++ + E I LK +T LK+ N+++ +P SI + ++E L S N++E+LP ++ L Sbjct: 669 NIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSL 728 Query: 322 TNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLK 381 LR +N + +P EIG +N+ L + NK++ LP+++ KL+ +NL N + Sbjct: 729 QKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCIT 788 Query: 382 NLPFSFTKLQQLTAMWLSDN 401 +LP +L QLT + L N Sbjct: 789 SLPEKVGQLSQLTQLELKGN 808 Score = 89.7 bits (221), Expect = 2e-17 Identities = 59/191 (30%), Positives = 101/191 (52%), Gaps = 5/191 (2%) Query: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLS---LPDND 80 V L+ +C LE++P IF+ L+EL L +N I + +++ + Q L +L+ L N Sbjct: 637 VAELELQNCELERIPHAIFSL-SNLQELDLKSNNIRTI-EEIISFQHLKRLTCLKLWHNK 694 Query: 81 LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNL 140 + T+P SI ++ NL L S N ++ P + + + L ++ S N IS +P L NL Sbjct: 695 IVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNL 754 Query: 141 TQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP 200 L++ ++ LP + KL+ L L +N + LP+ + +L+QL +L+L N +P Sbjct: 755 QHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 814 Query: 201 EVLEQLSGLKE 211 L Q LK+ Sbjct: 815 AQLGQCRMLKK 825 Score = 89.0 bits (219), Expect = 3e-17 Identities = 74/285 (25%), Positives = 135/285 (47%), Gaps = 9/285 (3%) Query: 127 ISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQ- 185 +S +PD L +L L L +PA ++T LQ L L K+ + L Sbjct: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDH 538 Query: 186 LERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIG--SLKQLTYLDVS--KNN 241 L L + + E+P + L L+E ++ N + IG SL++L +L + K+N Sbjct: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598 Query: 242 IEMVEEGIS-TCENLQDLLLSSNSLQQLP-ETIGSLKNITTLKIDENQLMYLPDSIGGLI 299 + V I+ +L L++ ++ + L ++ + N+ L++ +L +P +I L Sbjct: 599 LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLS 658 Query: 300 SVEELDCSFNEVEALPSSIG--QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKL 357 +++ELD N + + I L L HN + +PP I KN+ L+ +NKL Sbjct: 659 NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKL 718 Query: 358 ETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402 E+LP + +QKL+ +++S N + +P LQ L + ++ N+ Sbjct: 719 ESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNK 763 >gi|34222199 leucine rich repeat containing 8 family, member D [Homo sapiens] Length = 858 Score = 110 bits (276), Expect = 7e-24 Identities = 87/323 (26%), Positives = 153/323 (47%), Gaps = 31/323 (9%) Query: 71 LHKLSLPDNDLTTLPASIANLINLRELDV-----SKNGIQEFPENIKNCKVLTIVEASVN 125 L L + D+ +PA + L NLREL + S+N E+++ + L I+ N Sbjct: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598 Query: 126 PISKLPDGFSQLL-NLTQLYLNDAFLEFLPAN-FGRLTKLQILELRENQLKMLPKTMNRL 183 ++K+P + + +LT+L +++ + L N ++ + LEL+ +L+ +P + L Sbjct: 599 -LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSL 657 Query: 184 TQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIE 243 + L+ LDL SN + E++ LK+LT L + N I Sbjct: 658 SNLQELDLKSNNIRTIEEIIS---------------------FQHLKRLTCLKLWHNKIV 696 Query: 244 MVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEE 303 + I+ +NL+ L S+N L+ LP + SL+ + L + N + +P IG L +++ Sbjct: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQH 756 Query: 304 LDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE 363 L + N+V+ LP + + LRT N + LP ++G +T L L N L+ LP + Sbjct: 757 LHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQ 816 Query: 364 MGDMQKLKVINL--SDNRLKNLP 384 +G + LK L D+ LP Sbjct: 817 LGQCRMLKKSGLVVEDHLFDTLP 839 Score = 110 bits (274), Expect = 1e-23 Identities = 100/380 (26%), Positives = 175/380 (46%), Gaps = 46/380 (12%) Query: 42 FTFEKTLEELYLDANQIEEL--------PKQLFNCQSLHKLSLPDNDLTTLPASIANLIN 93 +TFEK + + +A +EL P +F+ L L L +PA I+ + N Sbjct: 455 WTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTN 514 Query: 94 LRELDVSKNGIQEFPENIKNCKV------LTIVEASVNPISKLPDGFSQLLNLTQLYLND 147 L+EL + P ++ L + ++++P L NL +LYL Sbjct: 515 LQELHLC-----HCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYL-- 567 Query: 148 AFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP----EVL 203 G L EN + +++ L L+ L + SN T+VP +V Sbjct: 568 ---------IGNLNS-------ENNKMIGLESLRELRHLKILHVKSN-LTKVPSNITDVA 610 Query: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263 L+ L D +L + + + + L++ +E + I + NLQ+L L SN Sbjct: 611 PHLTKLV-IHNDGTKLLVLNS-LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSN 668 Query: 264 SLQQLPETIG--SLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQL 321 +++ + E I LK +T LK+ N+++ +P SI + ++E L S N++E+LP ++ L Sbjct: 669 NIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSL 728 Query: 322 TNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLK 381 LR +N + +P EIG +N+ L + NK++ LP+++ KL+ +NL N + Sbjct: 729 QKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCIT 788 Query: 382 NLPFSFTKLQQLTAMWLSDN 401 +LP +L QLT + L N Sbjct: 789 SLPEKVGQLSQLTQLELKGN 808 Score = 89.7 bits (221), Expect = 2e-17 Identities = 59/191 (30%), Positives = 101/191 (52%), Gaps = 5/191 (2%) Query: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLS---LPDND 80 V L+ +C LE++P IF+ L+EL L +N I + +++ + Q L +L+ L N Sbjct: 637 VAELELQNCELERIPHAIFSL-SNLQELDLKSNNIRTI-EEIISFQHLKRLTCLKLWHNK 694 Query: 81 LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNL 140 + T+P SI ++ NL L S N ++ P + + + L ++ S N IS +P L NL Sbjct: 695 IVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNL 754 Query: 141 TQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP 200 L++ ++ LP + KL+ L L +N + LP+ + +L+QL +L+L N +P Sbjct: 755 QHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 814 Query: 201 EVLEQLSGLKE 211 L Q LK+ Sbjct: 815 AQLGQCRMLKK 825 Score = 89.0 bits (219), Expect = 3e-17 Identities = 74/285 (25%), Positives = 135/285 (47%), Gaps = 9/285 (3%) Query: 127 ISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQ- 185 +S +PD L +L L L +PA ++T LQ L L K+ + L Sbjct: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDH 538 Query: 186 LERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIG--SLKQLTYLDVS--KNN 241 L L + + E+P + L L+E ++ N + IG SL++L +L + K+N Sbjct: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598 Query: 242 IEMVEEGIS-TCENLQDLLLSSNSLQQLP-ETIGSLKNITTLKIDENQLMYLPDSIGGLI 299 + V I+ +L L++ ++ + L ++ + N+ L++ +L +P +I L Sbjct: 599 LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLS 658 Query: 300 SVEELDCSFNEVEALPSSIG--QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKL 357 +++ELD N + + I L L HN + +PP I KN+ L+ +NKL Sbjct: 659 NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKL 718 Query: 358 ETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402 E+LP + +QKL+ +++S N + +P LQ L + ++ N+ Sbjct: 719 ESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNK 763 >gi|37221175 PH domain and leucine rich repeat protein phosphatase [Homo sapiens] Length = 1205 Score = 105 bits (261), Expect = 4e-22 Identities = 110/424 (25%), Positives = 186/424 (43%), Gaps = 63/424 (14%) Query: 34 LEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT---TLPAS--- 87 L QV K + + + L +E LP LF Q L L+L N L +LPA+ Sbjct: 116 LRQVSK---VASQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGL 172 Query: 88 --IANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYL 145 + L+ L++S N + +FP + C + T+ E +V+ + Sbjct: 173 NELQRFTKLKSLNLSNNHLGDFPLAV--CSIPTLAELNVSCNA----------------- 213 Query: 146 NDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQ 205 L +PA G + LQ L N L+ LP + + QL L L NEFT++PEVLE+ Sbjct: 214 ----LRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEK 269 Query: 206 LSGLKEFWMDANRL-TFIPGFIGSLKQLTYLDVSKNNI-EMVEEGISTCENLQDLLLSSN 263 L+ + + M N + T + + + ++D+ N I +++ + + +++ L L N Sbjct: 270 LTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDN 329 Query: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS--------------------VEE 303 L L I NI L + NQL+ L D G + + Sbjct: 330 KLGDLDAMI--FNNIEVLHCERNQLVTL-DICGYFLKALYASSNELVQLDVYPVPNYLSY 386 Query: 304 LDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE 363 +D S N +E +P + + L HN + +LP + ++ L N+L LPE Sbjct: 387 MDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLPER 446 Query: 364 MGDMQKLKVINLSDNRLKNLPFS-FTKLQQLTAMWLSDNQSKPLIP--LQKETDSETQKM 420 + + ++V+++ N+L LP + K L + S N+ + L P L +ET+S Q++ Sbjct: 447 L-ERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQEL 505 Query: 421 VLTN 424 LTN Sbjct: 506 YLTN 509 Score = 85.5 bits (210), Expect = 3e-16 Identities = 105/429 (24%), Positives = 184/429 (42%), Gaps = 78/429 (18%) Query: 23 TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82 T+ L+ S +L VP + L+ LD N ++ LP +L N + L L L N+ T Sbjct: 203 TLAELNVSCNALRSVPAAVGVMHN-LQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFT 261 Query: 83 TLPASIANLINLRELDVSKNGIQEFP-ENIKNCKVLTIVEASVNPISKL-PDGFSQLLNL 140 +P + L + +L +S N ++ + ++ + V+ +N I KL D L ++ Sbjct: 262 DIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHV 321 Query: 141 TQLYLNDA-------------------------------FLEFLPANFGRLTKLQI---- 165 TQL L D FL+ L A+ L +L + Sbjct: 322 TQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLDICGYFLKALYASSNELVQLDVYPVP 381 Query: 166 -----LELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLT 220 +++ N+L+ +P+ + +LE LD+G N+ E+P L S L++ N+L Sbjct: 382 NYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLA 441 Query: 221 FIP-----------------------GFIGSLKQLTYLDVSKNNIEMVEEGISTCEN--- 254 +P + L +L+ S N +E + + E Sbjct: 442 RLPERLERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSI 501 Query: 255 LQDLLLSSNSLQQ--LPETIGSLKNITTLKIDENQLMYLPDS-IGGLISVEELDCSFNEV 311 LQ+L L++NSL +P G ++ L + N+L P S + L +EE+D S N++ Sbjct: 502 LQELYLTNNSLTDKCVPLLTGH-PHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKL 560 Query: 312 EALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLE--TLPEEMGDMQK 369 +A+P++I + T A N ++ PE+ I + L N+L TLPE + K Sbjct: 561 KAIPTTIMNCRRMHTVIAHSNCIEVF-PEVMQLPEIKCVDLSCNELSEVTLPENL--PPK 617 Query: 370 LKVINLSDN 378 L+ ++L+ N Sbjct: 618 LQELDLTGN 626 Score = 69.7 bits (169), Expect = 2e-11 Identities = 84/355 (23%), Positives = 149/355 (41%), Gaps = 41/355 (11%) Query: 33 SLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLI 92 S E V +++ L + + N++E +P+ + + L L + N + LPA + Sbjct: 369 SNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNS 428 Query: 93 NLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEF 152 +LR+L N + PE ++ V +++ N + +LP L + L F Sbjct: 429 SLRKLLAGHNQLARLPERLERTSV-EVLDVQHNQLLELP---------PNLLMKADSLRF 478 Query: 153 LPANFGRLTKLQILELRENQLKMLPKTMNRLTQ--LERLDLGSNEFTE--VPEVLEQLSG 208 L A+ +L L P T++ T L+ L L +N T+ VP +L Sbjct: 479 LNASANKLESLP------------PATLSEETNSILQELYLTNNSLTDKCVP-LLTGHPH 525 Query: 209 LKEFWMDANRLTFIPGF-IGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQ 267 LK M NRL P + L++L +D+S N ++ + I C + ++ SN ++ Sbjct: 526 LKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEV 585 Query: 268 LPETIGSLKNITTLKIDENQL--MYLPDSIGGLISVEELDCSFNEVEALP-SSIGQLTNL 324 PE + L I + + N+L + LP+++ ++ELD + N L ++ L N+ Sbjct: 586 FPEVM-QLPEIKCVDLSCNELSEVTLPENLPP--KLQELDLTGNPRLVLDHKTLELLNNI 642 Query: 325 RTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNR 379 R F D P G ++ H + + + L V N DNR Sbjct: 643 RCFKIDQ-------PSTGDASGAPAVWSHGYTEASGVKNKLCVAALSVNNFCDNR 690 Score = 50.1 bits (118), Expect = 1e-05 Identities = 57/200 (28%), Positives = 85/200 (42%), Gaps = 34/200 (17%) Query: 18 RGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQS---LHKL 74 R E +V LD H L ++P + +L L AN++E LP + ++ L +L Sbjct: 446 RLERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQEL 505 Query: 75 SLPDNDLT------------------------TLPAS-IANLINLRELDVSKNGIQEFPE 109 L +N LT + PAS +A L L E+D+S N ++ P Sbjct: 506 YLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPT 565 Query: 110 NIKNCKVLTIVEASVNPISKLPDGFSQL--LNLTQLYLNDAFLEFLPANFGRLTKLQILE 167 I NC+ + V A N I P+ QL + L N+ LP N KLQ L+ Sbjct: 566 TIMNCRRMHTVIAHSNCIEVFPE-VMQLPEIKCVDLSCNELSEVTLPENLP--PKLQELD 622 Query: 168 LREN-QLKMLPKTMNRLTQL 186 L N +L + KT+ L + Sbjct: 623 LTGNPRLVLDHKTLELLNNI 642 Score = 38.9 bits (89), Expect = 0.032 Identities = 36/139 (25%), Positives = 63/139 (45%), Gaps = 8/139 (5%) Query: 3 TKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELP 62 T SL + VP L G + L ++ L+ P + LEE+ L N+++ +P Sbjct: 508 TNNSLTDKCVPL--LTGHPH-LKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIP 564 Query: 63 KQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQE--FPENIKNCKVLTIV 120 + NC+ +H + N + P + L ++ +D+S N + E PEN+ L + Sbjct: 565 TTIMNCRRMHTVIAHSNCIEVFP-EVMQLPEIKCVDLSCNELSEVTLPENLP--PKLQEL 621 Query: 121 EASVNPISKLPDGFSQLLN 139 + + NP L +LLN Sbjct: 622 DLTGNPRLVLDHKTLELLN 640 >gi|4504379 leucine-rich repeat-containing G protein-coupled receptor 5 [Homo sapiens] Length = 907 Score = 105 bits (261), Expect = 4e-22 Identities = 117/438 (26%), Positives = 191/438 (43%), Gaps = 68/438 (15%) Query: 14 CRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEEL-PKQLFNCQSLH 72 C C + + +D S L ++P + F L+ L N I +L P L + + L Sbjct: 38 CHC-EPDGRMLLRVDCSDLGLSELPSNLSVFTSYLD---LSMNNISQLLPNPLPSLRFLE 93 Query: 73 KLSLPDNDLTTLP-ASIANLINLRELDVSKNGIQEFP-ENIKNCKVLTIVEASVNPISKL 130 +L L N LT +P + L +L+ L + N ++ P E ++N + L + N IS + Sbjct: 94 ELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYV 153 Query: 131 PDG-FSQLLNLTQLYLNDAFLEFLPAN-------------------------FGRLTKLQ 164 P FS L +L L+L+D L +P FG L+ L Sbjct: 154 PPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLV 213 Query: 165 ILELRENQLKML-PKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIP 223 +L L N++ L K + L LE LDL N E P + LS LKE +N + IP Sbjct: 214 VLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIP 273 Query: 224 --GFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDL----LLSSNSLQQLPETIGSLKN 277 F+G+ +T + N I+ V G S ++L +L L ++ + + P+ G+ N Sbjct: 274 EKAFVGNPSLIT-IHFYDNPIQFV--GRSAFQHLPELRTLTLNGASQITEFPDLTGT-AN 329 Query: 278 ITTLKIDENQLMYLPDSI-GGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQ 336 + +L + Q+ LP ++ L +++ LD S+N +E LP S L+ HN + + Sbjct: 330 LESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLP-SFSVCQKLQKIDLRHNEIYE 388 Query: 337 LPPEIG-----------SWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPF 385 + + +W I + +H N TLP L ++LS N L + P Sbjct: 389 IKVDTFQQLLSLRSLNLAWNKIAI--IHPNAFSTLP-------SLIKLDLSSNLLSSFP- 438 Query: 386 SFTKLQQLTAMWLSDNQS 403 T L LT + L+ N + Sbjct: 439 -ITGLHGLTHLKLTGNHA 455 >gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] Length = 277 Score = 105 bits (261), Expect = 4e-22 Identities = 75/196 (38%), Positives = 95/196 (48%), Gaps = 24/196 (12%) Query: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83 +T L SH L VP I K LE L NQIEELP Q+ + Q L L+L N L T Sbjct: 42 ITQLVLSHNKLTMVPPNIAEL-KNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNT 100 Query: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143 LP +L L LD++ N + E + LP F L L L Sbjct: 101 LPRGFGSLPALEVLDLTYNNLSE---------------------NSLPGNFFYLTTLRAL 139 Query: 144 YLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203 YL+D E LP + G+LTKLQIL LR+N L LPK + LTQL+ L + N T +P L Sbjct: 140 YLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPEL 199 Query: 204 E--QLSGLKEFWMDAN 217 L+G K+ + N Sbjct: 200 GNLDLTGQKQVFKAEN 215 Score = 98.6 bits (244), Expect = 3e-20 Identities = 59/167 (35%), Positives = 91/167 (54%), Gaps = 2/167 (1%) Query: 65 LFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASV 124 LF + +L L N LT +P +IA L NL L+ N I+E P I + + L + + Sbjct: 36 LFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGM 95 Query: 125 NPISKLPDGFSQL--LNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNR 182 N ++ LP GF L L + L N+ LP NF LT L+ L L +N ++LP + + Sbjct: 96 NRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGK 155 Query: 183 LTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSL 229 LT+L+ L L N+ +P+ + +L+ LKE + NRLT +P +G+L Sbjct: 156 LTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 202 Score = 98.6 bits (244), Expect = 3e-20 Identities = 55/159 (34%), Positives = 90/159 (56%), Gaps = 2/159 (1%) Query: 228 SLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQ 287 +L +T L +S N + MV I+ +NL+ L +N +++LP I SL+ + L + N+ Sbjct: 38 TLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNR 97 Query: 288 LMYLPDSIGGLISVEELDCSFNEVE--ALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWK 345 L LP G L ++E LD ++N + +LP + LT LR N + LPP+IG Sbjct: 98 LNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLT 157 Query: 346 NITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP 384 + +L L N L +LP+E+G++ +LK +++ NRL LP Sbjct: 158 KLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLP 196 Score = 91.7 bits (226), Expect = 4e-18 Identities = 64/207 (30%), Positives = 94/207 (45%), Gaps = 13/207 (6%) Query: 228 SLKQLTYLDVSKNN--IEMVEEGIS---------TCENLQDLLLSSNSLQQLPETIGSLK 276 SLK+L KN ++M + GIS T ++ L+LS N L +P I LK Sbjct: 4 SLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELK 63 Query: 277 NITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQ 336 N+ L NQ+ LP I L ++ L+ N + LP G L L +N L + Sbjct: 64 NLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSE 123 Query: 337 --LPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLT 394 LP + L+L N E LP ++G + KL++++L DN L +LP +L QL Sbjct: 124 NSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLK 183 Query: 395 AMWLSDNQSKPLIPLQKETDSETQKMV 421 + + N+ L P D QK V Sbjct: 184 ELHIQGNRLTVLPPELGNLDLTGQKQV 210 Score = 86.3 bits (212), Expect = 2e-16 Identities = 57/178 (32%), Positives = 86/178 (48%), Gaps = 5/178 (2%) Query: 160 LTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRL 219 L+ + L L N+L M+P + L LE L+ +N+ E+P + L LK + NRL Sbjct: 39 LSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 98 Query: 220 TFIPGFIGSLKQLTYLDVSKNNI--EMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKN 277 +P GSL L LD++ NN+ + L+ L LS N + LP IG L Sbjct: 99 NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 158 Query: 278 ITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLT---NLRTFAADHN 332 + L + +N L+ LP IG L ++EL N + LP +G L + F A++N Sbjct: 159 LQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENN 216 Score = 55.1 bits (131), Expect = 4e-07 Identities = 38/115 (33%), Positives = 54/115 (46%), Gaps = 5/115 (4%) Query: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83 V L Y++ S +P F + TL LYL N E LP + L LSL DNDL + Sbjct: 113 VLDLTYNNLSENSLPGNFF-YLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLIS 171 Query: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVL---TIVEASVNP-ISKLPDGF 134 LP I L L+EL + N + P + N + + +A NP ++ + D F Sbjct: 172 LPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQF 226 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.311 0.129 0.361 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 51,328,200 Number of Sequences: 37866 Number of extensions: 2471816 Number of successful extensions: 10946 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 157 Number of HSP's successfully gapped in prelim test: 438 Number of HSP's that attempted gapping in prelim test: 7428 Number of HSP's gapped (non-prelim): 2000 length of query: 1302 length of database: 18,247,518 effective HSP length: 114 effective length of query: 1188 effective length of database: 13,930,794 effective search space: 16549783272 effective search space used: 16549783272 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.8 bits) S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.