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Search of human proteins with 55749696
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55749696 outer dense fiber of sperm tails 2-like isoform a
[Homo sapiens]
(644 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55749696 outer dense fiber of sperm tails 2-like isoform a [H... 1249 0.0
gi|55749708 outer dense fiber of sperm tails 2-like isoform b [H... 996 0.0
gi|24430181 outer dense fiber of sperm tails 2 isoform 1 [Homo s... 297 2e-80
gi|24430183 outer dense fiber of sperm tails 2 isoform 2 [Homo s... 195 9e-50
gi|55770834 centromere protein F [Homo sapiens] 119 7e-27
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 114 2e-25
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 104 3e-22
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 104 3e-22
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 104 3e-22
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 104 3e-22
gi|71061468 centromere protein E [Homo sapiens] 103 5e-22
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 103 5e-22
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 102 1e-21
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 102 1e-21
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 100 4e-21
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 100 4e-21
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 100 5e-21
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 100 7e-21
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 99 1e-20
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 99 2e-20
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 98 2e-20
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 98 3e-20
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 98 3e-20
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 97 4e-20
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 97 5e-20
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 97 6e-20
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 97 6e-20
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 96 8e-20
gi|4758650 kinesin family member 5C [Homo sapiens] 94 3e-19
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 94 3e-19
>gi|55749696 outer dense fiber of sperm tails 2-like isoform a [Homo
sapiens]
Length = 644
Score = 1249 bits (3232), Expect = 0.0
Identities = 644/644 (100%), Positives = 644/644 (100%)
Query: 1 MEKAVNDGSHSEELFCHLKTISEKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELV 60
MEKAVNDGSHSEELFCHLKTISEKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELV
Sbjct: 1 MEKAVNDGSHSEELFCHLKTISEKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELV 60
Query: 61 THSVELLLPLFKDTIEKINFENANLSALNLKISEQKEILIKELDTFKSVKLALEHLLRKR 120
THSVELLLPLFKDTIEKINFENANLSALNLKISEQKEILIKELDTFKSVKLALEHLLRKR
Sbjct: 61 THSVELLLPLFKDTIEKINFENANLSALNLKISEQKEILIKELDTFKSVKLALEHLLRKR 120
Query: 121 DYKQTGDNLSSMLLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQ 180
DYKQTGDNLSSMLLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQ
Sbjct: 121 DYKQTGDNLSSMLLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQ 180
Query: 181 SVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTV 240
SVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTV
Sbjct: 181 SVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTV 240
Query: 241 ALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEV 300
ALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEV
Sbjct: 241 ALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEV 300
Query: 301 QIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKD 360
QIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKD
Sbjct: 301 QIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKD 360
Query: 361 EVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNK 420
EVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNK
Sbjct: 361 EVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNK 420
Query: 421 NVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDG 480
NVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDG
Sbjct: 421 NVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDG 480
Query: 481 NHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKS 540
NHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKS
Sbjct: 481 NHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKS 540
Query: 541 AEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKM 600
AEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKM
Sbjct: 541 AEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKM 600
Query: 601 NSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSYVTMFE 644
NSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSYVTMFE
Sbjct: 601 NSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSYVTMFE 644
>gi|55749708 outer dense fiber of sperm tails 2-like isoform b [Homo
sapiens]
Length = 513
Score = 996 bits (2576), Expect = 0.0
Identities = 513/513 (100%), Positives = 513/513 (100%)
Query: 132 MLLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQI 191
MLLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQI
Sbjct: 1 MLLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQI 60
Query: 192 QIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQ 251
QIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQ
Sbjct: 61 QIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQ 120
Query: 252 RLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIIN 311
RLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIIN
Sbjct: 121 RLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIIN 180
Query: 312 LLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSE 371
LLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSE
Sbjct: 181 LLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSE 240
Query: 372 LQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMES 431
LQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMES
Sbjct: 241 LQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMES 300
Query: 432 HLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLE 491
HLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLE
Sbjct: 301 HLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLE 360
Query: 492 EENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLE 551
EENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLE
Sbjct: 361 EENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLE 420
Query: 552 AALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCL 611
AALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCL
Sbjct: 421 AALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCL 480
Query: 612 KEVQNSLEKSENQNESIKNYLQFLKTSYVTMFE 644
KEVQNSLEKSENQNESIKNYLQFLKTSYVTMFE
Sbjct: 481 KEVQNSLEKSENQNESIKNYLQFLKTSYVTMFE 513
Score = 52.4 bits (124), Expect = 1e-06
Identities = 66/348 (18%), Positives = 153/348 (43%), Gaps = 33/348 (9%)
Query: 25 EDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFENAN 84
EDL + SC ++IL + +E + L ++ L KD E ++ EN
Sbjct: 183 EDLKKMEDHGKNSC--EEILRKVHSIEYENETLNLENTKLKTTLAALKD--EVVSVEN-- 236
Query: 85 LSALNLKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESEN 144
++SE +E+ K+ + K ++ L + ++ ++L +N +++N
Sbjct: 237 ------ELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKS--RCENLLHKNNQITKTKN 288
Query: 145 TNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHK-REAEND-- 201
N++K + E+H++EL + S A + + +S++ + Q H RE +
Sbjct: 289 KNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVD 348
Query: 202 -------KLKEYVKSLETKIAKWNLQSRMN----KNEAIVMKEASRQKTVALKKASKVYK 250
KL ++ ++ NLQ ++ +N+ + K A++++ LK ++ +K
Sbjct: 349 GNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEE--CLKHSNLKFK 406
Query: 251 QRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQII 310
++ +T +L + + + K++E I ++ +S + I+ +LE ++ ++
Sbjct: 407 EKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRES---ALQIKILDLETELRKKNEEQN 463
Query: 311 NLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAAL 358
L+ + H + +E+ + E +NE++ LKT+ +
Sbjct: 464 QLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSYVTM 511
>gi|24430181 outer dense fiber of sperm tails 2 isoform 1 [Homo
sapiens]
Length = 805
Score = 297 bits (760), Expect = 2e-80
Identities = 186/629 (29%), Positives = 338/629 (53%), Gaps = 9/629 (1%)
Query: 24 KEDLPRCTSESHLSCL-KQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFEN 82
+ ++ R E + L K+ + EK L + L EAE+ + + KDTI K+ E
Sbjct: 156 RHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEK 215
Query: 83 ANLSALNLKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSM---LLENLTD 139
++ QKE+L+++L TF+ L LLR++ K+ + L LL+ L +
Sbjct: 216 QMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAE 275
Query: 140 NESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAE 199
+SE L + +K+ ++EL Q EKA A+ S+S++ + LQ Q+ +EAE
Sbjct: 276 ADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAE 335
Query: 200 NDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGA 259
N +L +K+LE + + + +K+ + +LKKA + K+R +
Sbjct: 336 NSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEY 395
Query: 260 IEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKM 319
E+L Q+ D++ ++E +S +W+S Y ++V EK +LE++I + ++ +L+ + +
Sbjct: 396 AEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTL 455
Query: 320 EDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQ 379
E+ + + ++ ++H E LEN +LK + A ++D++ E+ +L+ K
Sbjct: 456 EEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNY 515
Query: 380 KTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERV 439
+ +I+ YK+QV K + A+ V ++ E +N + NK +E R Q +S L +L+++
Sbjct: 516 EGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQL 575
Query: 440 CDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKL-----SLEEEN 494
D L E +L ECQ+ LQ + K D I +L+ +++ + L + ++EN
Sbjct: 576 PDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKEN 635
Query: 495 CLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAAL 554
+ LK + L++KLE A+N E + +A +EE + S L+ +EK+ E LARQLE+A+
Sbjct: 636 KQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAI 695
Query: 555 EEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEV 614
E+ R++V + E S+E A Q KILDLET+L + E +QL + + + L+++
Sbjct: 696 EDARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDL 755
Query: 615 QNSLEKSENQNESIKNYLQFLKTSYVTMF 643
++ LE+SE+ N S++NY+QFLK+SY +F
Sbjct: 756 KDRLEQSESTNRSMQNYVQFLKSSYANVF 784
Score = 60.5 bits (145), Expect = 5e-09
Identities = 108/502 (21%), Positives = 196/502 (39%), Gaps = 69/502 (13%)
Query: 193 IHKREAENDKLKEYVKSLETKIAKWNLQS--RMNKNEAIVMKEASRQKTVALKKASKVYK 250
+H EN + ++K L A + +S R K + + ++ + R KT K
Sbjct: 10 LHVHVDENTPVHVHIKKLPKPSATSSQKSHKRGMKGDTVNVRRSVRVKT-------KNPP 62
Query: 251 QRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKI-----VIEKTELEVQIETM 305
L+ + EKL S +R + + S + +KI + + EV+++
Sbjct: 63 HCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKG 122
Query: 306 KKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETL--NLENTKLKTTLAALKDEVV 363
++Q+ K+ + K EE+ ++ E+EN L N+E K + L+ + +
Sbjct: 123 ERQMA------KRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHL 176
Query: 364 SVENE--LSELQEVEK-----------------KQKTLIEMYKTQVQKLQEAAEIVKSRC 404
E E +S+L E E K KT +M T + L E++ +
Sbjct: 177 QQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKL 236
Query: 405 ENLLHKN--------NQITKTKNKNVEKMRGQMESHLKELE----RVCDSLTAAERRLHE 452
N Q K ++ + + +G + L E + R+ L ++ + E
Sbjct: 237 STFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEE 296
Query: 453 CQESLQCCKGKCADQEHTIRELQGQVDG--NHNLLTKLSLEEENCLIQLKCENLQQKLEQ 510
+ +QC K Q T EL ++ H S E EN + ++ +NL++ Q
Sbjct: 297 LLQEIQCEKA----QAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQ 352
Query: 511 MDAE-------NKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAE 563
AE KEL++K +E LK + KE++ + A QL L + VAE
Sbjct: 353 HKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAE 412
Query: 564 ---EIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEK 620
+E SR + + + DLE E+ N+ LV + + + + L +
Sbjct: 413 ALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHR 472
Query: 621 SENQNESIKNYLQFLKTSYVTM 642
+ + K + LK S+ M
Sbjct: 473 QTAEYSAFKLENERLKASFAPM 494
>gi|24430183 outer dense fiber of sperm tails 2 isoform 2 [Homo
sapiens]
Length = 638
Score = 195 bits (496), Expect = 9e-50
Identities = 128/469 (27%), Positives = 238/469 (50%), Gaps = 8/469 (1%)
Query: 24 KEDLPRCTSESHLSCL-KQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFEN 82
+ ++ R E + L K+ + EK L + L EAE+ + + KDTI K+ E
Sbjct: 161 RHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEK 220
Query: 83 ANLSALNLKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSM---LLENLTD 139
++ QKE+L+++L TF+ L LLR++ K+ + L LL+ L +
Sbjct: 221 QMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAE 280
Query: 140 NESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAE 199
+SE L + +K+ ++EL Q EKA A+ S+S++ + LQ Q+ +EAE
Sbjct: 281 ADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAE 340
Query: 200 NDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGA 259
N +L +K+LE + + + +K+ + +LKKA + K+R +
Sbjct: 341 NSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEY 400
Query: 260 IEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKM 319
E+L Q+ D++ ++E +S +W+S Y ++V EK +LE++I + ++ +L+ + +
Sbjct: 401 AEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTL 460
Query: 320 EDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQ 379
E+ + + ++ ++H E LEN +LK + A ++D++ E+ +L+ K
Sbjct: 461 EEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNY 520
Query: 380 KTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERV 439
+ +I+ YK+QV K + A+ V ++ E +N + NK +E R Q +S L +L+++
Sbjct: 521 EGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQL 580
Query: 440 CDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQV----DGNHNL 484
D L E +L ECQ+ LQ + K D I +L+ +V G+H L
Sbjct: 581 PDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKGSHEL 629
Score = 62.0 bits (149), Expect = 2e-09
Identities = 92/415 (22%), Positives = 174/415 (41%), Gaps = 40/415 (9%)
Query: 249 YKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQ 308
Y +++D A+ L S+++ Q+ + K E++ E E E + ++
Sbjct: 104 YDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHN 163
Query: 309 IINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENE 368
I E +K+ +D IL+K H ++ E E L + + + AA +V+++++
Sbjct: 164 I----ERMKEEKDF------TILQKKH-LQQEKECLMSKLVEAEMDGAAAAKQVMALKDT 212
Query: 369 LSELQEVEKKQ-----KTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVE 423
+ +L+ EK+ TL + +QKL E ++ + L Q K ++ +
Sbjct: 213 IGKLK-TEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLL---REQHCKEDSERLM 268
Query: 424 KMRGQMESHLKELE----RVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVD 479
+ +G + L E + R+ L ++ + E + +QC K Q T EL ++
Sbjct: 269 EQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKA----QAKTASELSKSME 324
Query: 480 G--NHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAEN-------KELEKKLANQEECLK 530
H S E EN + ++ +NL++ Q AE KEL++K +E LK
Sbjct: 325 SMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLK 384
Query: 531 HSNLKFKEKSAEYTALARQLEAALEEGRQKVAE---EIEKMSSRESALQIKILDLETELR 587
+ KE++ + A QL L + VAE +E SR + + + DLE E+
Sbjct: 385 KAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEII 444
Query: 588 KKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSYVTM 642
N+ LV + + + + L + + + K + LK S+ M
Sbjct: 445 VLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPM 499
Score = 59.7 bits (143), Expect = 8e-09
Identities = 105/571 (18%), Positives = 233/571 (40%), Gaps = 52/571 (9%)
Query: 32 SESHLSCLKQDILNEKTELEATLKEA----ELVTHSVELLLPLFKDTIEKINFENANLSA 87
++SH +K D +N + + K E+ S E L+ + + + +++
Sbjct: 41 TKSHKRGMKGDTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCK 100
Query: 88 LNLKISEQKEILIKELDTFKS-VKLAL-EHLLRKRDYKQTGDNLSSMLLENLTDNESENT 145
+N + ++ + L+ + KS VK+ E + KR ++ + L + E L + E ENT
Sbjct: 101 MN-RYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHE-LAETEHENT 158
Query: 146 NLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKE 205
L+ + + EK T+ + Q K E L ++ + E + +
Sbjct: 159 VLRHNIER-----------MKEEKDFTILQKKHLQQEK---ECLMSKLVEAEMDGAAAAK 204
Query: 206 YVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTS 265
V +L+ I K + +M + + +RQK + L Q+L F L
Sbjct: 205 QVMALKDTIGKLKTEKQMTCTD---INTLTRQKELLL--------QKLSTFEETNRTLRD 253
Query: 266 QIRDQEAK--LSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHG 323
+R+Q K + A + EK L + ++ K++ LL++++ +
Sbjct: 254 LLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQA 313
Query: 324 KNSCE----------EILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSEL- 372
K + E + ++ S E EN L ++ L+ + K EV ++ +L EL
Sbjct: 314 KTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELK 373
Query: 373 QEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESH 432
Q+ ++ +++L + + Q ++ +++ E + L K+ + + + +E R +
Sbjct: 374 QKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALS-TLESWRSRYNQV 432
Query: 433 LKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEE 492
+KE + + R+ + Q + K + ++ E + ++ + +
Sbjct: 433 VKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYS-----AFKL 487
Query: 493 ENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEA 552
EN ++ ++ KL Q E ++L+ + N E + + + + E +A QLE
Sbjct: 488 ENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLER 547
Query: 553 ALEEGRQKVAEEIEKMSSRESALQIKILDLE 583
+E + E +++ + Q ++ DL+
Sbjct: 548 CDKENKILKDEMNKEIEAARRQFQSQLADLQ 578
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 119 bits (299), Expect = 7e-27
Identities = 161/672 (23%), Positives = 307/672 (45%), Gaps = 108/672 (16%)
Query: 18 LKTISEKEDLPRCTSESH----LSCLK--QDILNEKTELEATLKE--AELV---THSVEL 66
L +SEK ESH L C++ + + EKTEL TL +EL+ TH E
Sbjct: 1977 LDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEK 2036
Query: 67 LLPLFKDTIEKINFENANLSALNLKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTG 126
L L KD+ + ++ L +++++KE+L+KE ++ L+ L + DY++
Sbjct: 2037 LQSLEKDS-QALSLTKCELENQIAQLNKEKELLVKESES-------LQARLSESDYEKL- 2087
Query: 127 DNLSSMLLENLTDNESENTNL---KKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVK 183
N+S L L + L +++V + I++L ++++ L
Sbjct: 2088 -NVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLH--------- 2137
Query: 184 VVHERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALK 243
+ E+L+ +RE END LK+ V++LE ++ S N+ I+ E S+ + LK
Sbjct: 2138 -IAEKLK----ERERENDSLKDKVENLERELQ----MSEENQELVILDAENSKAEVETLK 2188
Query: 244 -------KASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKT 296
++ KV++ L E LT QI++++ +LSE +++KS E EK
Sbjct: 2189 TQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLE----EKE 2244
Query: 297 ELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLA 356
+ E+QI+ K + +L+ N +E+ V ++ + E + L +
Sbjct: 2245 QAEIQIKEESKTAVEMLQ----------NQLKELNEAVAALCGDQEIMKATEQSLDPPIE 2294
Query: 357 ALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITK 416
S+E + L+ EKKQ +++ Q+++ + A+++K R EN L + +I +
Sbjct: 2295 EEHQLRNSIEKLRARLEADEKKQLCVLQ----QLKESEHHADLLKGRVEN-LERELEIAR 2349
Query: 417 TKNKN----VEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIR 472
T ++ E +G++E+ ++E + SL E + + + + ++ I
Sbjct: 2350 TNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERIS 2409
Query: 473 ELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLA----NQEEC 528
EL+ N+L E+E +Q+K E +E + + KEL +++A +QE C
Sbjct: 2410 ELEIINSSFENILQ----EKEQEKVQMK-EKSSTAMEMLQTQLKELNERVAALHNDQEAC 2464
Query: 529 LKHSNLKFKEKSAEYTALARQLE-AALEEGRQKVAEEIEKMSSRESALQIKILDLETELR 587
K KE++ +LE A L +G + + S + L ++ D + +L
Sbjct: 2465 ------KAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLE 2518
Query: 588 KKNEE----------QNQLVCKMNS--------KAQHQEV--CLKEVQNSLEKSENQNES 627
KK+EE Q QLV K++ K Q+ E+ E++ ++ +++N S
Sbjct: 2519 KKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNAS 2578
Query: 628 IKNYLQFLKTSY 639
+++ L+ L++SY
Sbjct: 2579 LQDTLEVLQSSY 2590
Score = 86.7 bits (213), Expect = 6e-17
Identities = 167/788 (21%), Positives = 299/788 (37%), Gaps = 204/788 (25%)
Query: 1 MEKAVNDGSHSEELFCHLKTISEKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELV 60
+ + + D +H +E L+ S+ L +C E+ ++ L N++ EL LV
Sbjct: 2023 VSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQL-----NKEKEL--------LV 2069
Query: 61 THSVELLLPLFKDTIEKINFENANLSALNLKISEQKEILIKELDTFKSVKLALEHLLRKR 120
S L L + EK+N A L + E+ E ++ T + V + + R
Sbjct: 2070 KESESLQARLSESDYEKLNVSKA----LEAALVEKGEFALRLSSTQEEVHQLRRGIEKLR 2125
Query: 121 DYKQTGDNLSSMLLENLTDNESENTNLKKKVFEKEAHIQ------ELSCL-FQSEKAN-- 171
+ + + E L + E EN +LK KV E +Q EL L ++ KA
Sbjct: 2126 VRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVE 2185
Query: 172 TLKAN--RFSQSVKVVH----------ERLQIQIHKRE---AENDKLKEYVKSL------ 210
TLK ++S+KV E L QI +++ +E DKL KSL
Sbjct: 2186 TLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQ 2245
Query: 211 -------ETKIAKWNLQSRMNK-NEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEK 262
E+K A LQ+++ + NEA+ ++ A +++ + +IEK
Sbjct: 2246 AEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEK 2305
Query: 263 LTSQIRDQEAK-------LSETISASNAWKSHYEKI--------------VIEKTELEVQ 301
L +++ E K L E+ ++ K E + +E + +
Sbjct: 2306 LRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGE 2365
Query: 302 IETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDE 361
+ET+K +I + + L+ +E V +I E E L E K + ++ L+
Sbjct: 2366 VETLKAKIEGMTQSLRGLE-----------LDVVTIRSEKENLTNELQKEQERISELEII 2414
Query: 362 VVSVENELSELQE----VEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKT 417
S EN L E ++ +++K T +EM +TQ+++L E LH + + K
Sbjct: 2415 NSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAA--------LHNDQEACKA 2466
Query: 418 KNKNV-------EKMRGQMESHLKELER-----------VCDSLTAAERRLHECQESLQC 459
K +N+ E + Q+ L E + + + +++L + E +
Sbjct: 2467 KEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISR 2526
Query: 460 CKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELE 519
K + DQE + +L QV+G H L + +LE N ++L +QK++ + ++N L+
Sbjct: 2527 LKNQIQDQEQLVSKLS-QVEGEHQLWKEQNLELRNLTVEL-----EQKIQVLQSKNASLQ 2580
Query: 520 ----------KKLANQEECLKHSNLKFKEK-----------------------------S 540
K L N+ E K + F EK S
Sbjct: 2581 DTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELS 2640
Query: 541 AEYTALARQLEAALEE-----------------------------------GRQKVAEEI 565
E LA +L+ LEE R+++AE
Sbjct: 2641 GEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQ 2700
Query: 566 EKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQN 625
++ E Q +LD N++ + K +E CL + ++ ++
Sbjct: 2701 LRLHEAEKKHQALLLD-------TNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSK 2753
Query: 626 ESIKNYLQ 633
E + N L+
Sbjct: 2754 EELNNSLK 2761
Score = 80.1 bits (196), Expect = 6e-15
Identities = 128/535 (23%), Positives = 227/535 (42%), Gaps = 90/535 (16%)
Query: 127 DNLSSMLLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVH 186
DN SS L L +++N L+ K+ E E +Q EK + N+F +
Sbjct: 272 DNSSSPHL--LDQLKAQNQELRNKINELELRLQG------HEKEMKGQVNKFQE------ 317
Query: 187 ERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKAS 246
LQ+Q+ K + E + ++ + ++ + Q ++A A QK LKK +
Sbjct: 318 --LQLQLEKAKVELIEKEKVLNKCRDELVRTTAQY----DQASTKYTALEQK---LKKLT 368
Query: 247 KVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMK 306
+ + + A L +I+++E + E +S ++ I+ MK
Sbjct: 369 EDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQ----------MK 418
Query: 307 KQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSV- 365
++ L+ K M N + L K+ S++ + E NLE K K A + +
Sbjct: 419 ARLTQELQQAKNMH----NVLQAELDKLTSVKQQLEN-NLEEFKQKLCRAEQAFQASQIK 473
Query: 366 ENELSELQEVEKKQKTLIEMYKTQ----VQKLQEAAEIVKSRCENLLHKNNQITKTKNKN 421
ENEL E KK+ L++ + Q V L+ + +K +C N + K KN +
Sbjct: 474 ENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIK-QCLNQSQNFAEEMKAKNTS 532
Query: 422 VEKMRGQMESHLKELERVCDSLTAAERRLH--ECQESLQCCKGKCADQEHTIRELQGQVD 479
E M ++ + + E +SLT + +L + ++ C + +EH I +L ++
Sbjct: 533 QETMLRDLQEKINQQE---NSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLS 589
Query: 480 GNHN----LLTKLSL---------EEENCLIQLKCENLQQKLEQMDAENKELEKKLANQE 526
LL+ L L EE+ K EN ++ L QM++E + L+ K+ + E
Sbjct: 590 KTEKESKALLSALELKKKEYEELKEEKTLFSCWKSEN-EKLLTQMESEKENLQSKINHLE 648
Query: 527 ECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLET-- 584
CLK + KS EY R LE R+ ++ EI + + L K +++ET
Sbjct: 649 TCLKTQQI----KSHEYNERVR----TLEMDRENLSVEIRNL---HNVLDSKSVEVETQK 697
Query: 585 ----ELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFL 635
EL++K E +Q + + + +CLK Q + Q E +++ LQ L
Sbjct: 698 LAYMELQQKAEFSDQ-----KHQKEIENMCLKTSQLT-----GQVEDLEHKLQLL 742
Score = 79.3 bits (194), Expect = 1e-14
Identities = 130/596 (21%), Positives = 248/596 (41%), Gaps = 83/596 (13%)
Query: 32 SESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSALNLK 91
SE H LK + N + ELE E E + KI +L L L
Sbjct: 2327 SEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELD 2386
Query: 92 ---ISEQKEILIKELDT-------FKSVKLALEHLLRKRDY-----KQTGDNLSSML--- 133
I +KE L EL + + + E++L++++ K+ ML
Sbjct: 2387 VVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQ 2446
Query: 134 LENLTDNESENTNLKKKVFEKEAHIQ-ELSCLFQSEKANTLKA---------------NR 177
L+ L + + N ++ KE ++ ++ CL + EKA L+ N
Sbjct: 2447 LKELNERVAALHNDQEACKAKEQNLSSQVECL-ELEKAQLLQGLDEAKNNYIVLQSSVNG 2505
Query: 178 FSQSVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEAS-- 235
Q V+ ++L+ K++ E +LK ++ E ++K + + E + KE +
Sbjct: 2506 LIQEVEDGKQKLE----KKDEEISRLKNQIQDQEQLVSKLS----QVEGEHQLWKEQNLE 2557
Query: 236 -RQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIE 294
R TV L++ +V + + +E L S ++ E +L T ++ K+ +
Sbjct: 2558 LRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAK 2617
Query: 295 KTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTT 354
+TEL+ ++ M ++ L E+L ++ + +L ++ S + + + L LEN++LK +
Sbjct: 2618 ETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKS 2677
Query: 355 LAALKDEVVSVENELSE--------LQEVEKK-QKTLIEMYKTQVQKLQEAAEIVKSRCE 405
L + + V E ++ E L E EKK Q L++ K ++Q E + S+ E
Sbjct: 2678 LDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEE 2737
Query: 406 NLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCA 465
L + +I K+ E + +SL A + L E +++ K
Sbjct: 2738 CLSSQKLEIDLLKSSK---------------EELNNSLKATTQILEELKKT----KMDNL 2778
Query: 466 DQEHTIRELQGQVDGNHNLLTK--LSLEEENCLIQLKCENLQQKLEQ------MDAENKE 517
+ +++ + G LL K LEEE ++Q + LQ E+ MD + E
Sbjct: 2779 KYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDE 2838
Query: 518 LEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRES 573
L ++ +E L+ + E +Y +L E LE+ ++ + ++ + S++S
Sbjct: 2839 LTTEIKELKETLEEKTKEADEYLDKYCSLLISHE-KLEKAKEMLETQVAHLCSQQS 2893
Score = 75.1 bits (183), Expect = 2e-13
Identities = 150/713 (21%), Positives = 292/713 (40%), Gaps = 127/713 (17%)
Query: 18 LKTISEKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEK 77
LK+ SE++ C E+ L +KQ LN+ +K S E +L +D EK
Sbjct: 491 LKSHSEQKAREVCHLEAELKNIKQ-CLNQSQNFAEEMKAKNT---SQETML---RDLQEK 543
Query: 78 INFENANLSALNLKIS---------------EQKEILIKELD-----TFKSVKLALEHL- 116
IN + +L+ LK++ +++E I++L+ T K K L L
Sbjct: 544 INQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALE 603
Query: 117 LRKRDYKQTGDN---LSSMLLEN---LTDNESENTNLKKKVFEKEAHIQELSCLFQSEKA 170
L+K++Y++ + S EN LT ESE NL+ K+ E +CL K
Sbjct: 604 LKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLE------TCL----KT 653
Query: 171 NTLKANRFSQSVKVVH-ERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAI 229
+K++ +++ V+ + +R + + R N + V+ K+A LQ + ++
Sbjct: 654 QQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQK 713
Query: 230 VMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKL----SETISASNAWK 285
KE + +V + L+H ++ L+++I D++ +E S + K
Sbjct: 714 HQKEIENMCLKTSQLTGQV--EDLEH---KLQLLSNEIMDKDRCYQDLHAEYESLRDLLK 768
Query: 286 SHYEKIVIEKTELEV-----QIETMKKQIINLLEDLKKME----------DHGKNSCEEI 330
S +V + Q M N++ + M D + +
Sbjct: 769 SKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAIL 828
Query: 331 LRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSE-LQEVEKKQKTLIEMYKTQ 389
+V S+E+ E+ N+ L+ +E+V ++ E+ E L + E+ ++ + +
Sbjct: 829 QNRVDSLEFSLESQKQMNSDLQKQC----EELVQIKGEIEENLMKAEQMHQSFVAETSQR 884
Query: 390 VQKLQE--------AAEIVKSRCEN------LLHKNNQITKTKNKNVEKMRGQMESHLKE 435
+ KLQE AE + S EN LL+ + + + + ++K +E LKE
Sbjct: 885 ISKLQEDTSAHQNVVAETL-SALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKE 943
Query: 436 LERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNH-NLLTKLSL---- 490
L+ + ++L+ ++ + + + + T++E+ ++ NL+ K
Sbjct: 944 LQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANY 1003
Query: 491 --EEENCLIQLKCENLQQKLE--QMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTAL 546
E E + +L + Q+KL Q E + L+ + + + N K + E T+L
Sbjct: 1004 IDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSL 1063
Query: 547 ARQLEAALEEGRQKVAEE----IEKMSSRESALQIKILDLET------------------ 584
+ LE+ ++ A+E + K++ E Q +L+LET
Sbjct: 1064 CENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKS 1123
Query: 585 -------ELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKN 630
E+ EEQN++ ++N Q E +K ++ E ++E I+N
Sbjct: 1124 EAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRN 1176
Score = 73.6 bits (179), Expect = 5e-13
Identities = 135/661 (20%), Positives = 273/661 (41%), Gaps = 94/661 (14%)
Query: 19 KTISEKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKI 78
K I E E L + L CL++ L+E + + L VT +E L K E++
Sbjct: 1579 KEIQELEQL-LSSERQELDCLRKQYLSENEQWQQKLTS---VTLEMESKLAAEKKQTEQL 1634
Query: 79 NFEN--ANLSALNLKISEQKEILIKELDTFK----SVKLALEHLLR------KRDYKQTG 126
+ E A L L +S + + I D + S ++ EH K D Q
Sbjct: 1635 SLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQIC 1694
Query: 127 DNLS----SMLLENLTDN------------ESENTNLKKKVFEKEAHIQELSCLFQSEKA 170
D + ++ +E +T+ +S +TN + +K E
Sbjct: 1695 DKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGP 1754
Query: 171 NTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAKW-----NLQSRMNK 225
N L F + + +H LQ+++ + EN +L ++ + K+ L S+++
Sbjct: 1755 NALVPMDFLGNQEDIHN-LQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHL 1813
Query: 226 NEAIVMKEASR----QKTVA-LKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISA 280
E +M + +K V LKK + ++L++F+ ++L ++ E S+
Sbjct: 1814 QEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDL--E 1871
Query: 281 SNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEIL---RKVHSI 337
+A KS E I ++ ++ K++ +++ +L ++ + E L + +
Sbjct: 1872 MHADKSSREDIGDNVAKVN---DSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVV 1928
Query: 338 EYENETLNLENTKLKTTLAALKDEVVSVENELSELQ---EVEKKQKTLIEMYKTQVQKLQ 394
+ E L +N + + L++E+ V +E ++L+ + K+ T ++ ++++
Sbjct: 1929 QTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKT 1988
Query: 395 EAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQ 454
+ E +S C + + K K + ++ + + LK+ + + L + E+
Sbjct: 1989 QELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEK------ 2042
Query: 455 ESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAE 514
+S KC EL+ Q+ L +E L+ + E+LQ +L + D E
Sbjct: 2043 DSQALSLTKC--------ELENQI---------AQLNKEKELLVKESESLQARLSESDYE 2085
Query: 515 ----NKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLE------AALEEGRQKVAEE 564
+K LE L + E L+ E L R +E A E+ + +AE+
Sbjct: 2086 KLNVSKALEAALVEKGEFA----LRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEK 2141
Query: 565 IEKMSSRESALQIKILDLETELRKKNEEQNQLVCKM-NSKAQHQ--EVCLKEVQNSLEKS 621
+++ +L+ K+ +LE EL+ E Q ++ NSKA+ + + ++E+ SL+
Sbjct: 2142 LKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVF 2201
Query: 622 E 622
E
Sbjct: 2202 E 2202
Score = 71.2 bits (173), Expect = 3e-12
Identities = 137/658 (20%), Positives = 258/658 (39%), Gaps = 130/658 (19%)
Query: 36 LSCLKQDILNEKTELEATLK--EAEL---VTHSVELLLPLFKDTIEKINFENANLSALNL 90
L Q++ N+ ELE L+ E E+ V EL L L K +E I E LN
Sbjct: 283 LKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKV----LN- 337
Query: 91 KISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESENTNLKKK 150
K ++ + D + ALE L+K L+ L + ES +L++K
Sbjct: 338 KCRDELVRTTAQYDQASTKYTALEQKLKK---------LTEDLSCQRQNAESARCSLEQK 388
Query: 151 VFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQ-IHK-REAENDKLKEYVK 208
+ EKE QE Q TL ++ E Q + +H +AE DKL +
Sbjct: 389 IKEKEKEFQE-ELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQ 447
Query: 209 SLETKIAKWNLQ----------SRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTG 258
LE + ++ + S++ +NE E +++ LK S+ + + H
Sbjct: 448 QLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEA 507
Query: 259 AIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKK 318
++ + Q +Q +E + A N + + + EK + T++K + + DL+K
Sbjct: 508 ELKNI-KQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKL-AVADLEK 565
Query: 319 MEDHGKNSCEEILRK-VHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEK 377
D +++L+K H IE N+ L+ + K L+AL E + E +E+ K
Sbjct: 566 QRD----CSQDLLKKREHHIEQLNDKLSKTEKESKALLSAL-------ELKKKEYEEL-K 613
Query: 378 KQKTLIEMYKTQVQKLQEAAEIVKSRCENLL--------------HKNNQITKT------ 417
++KTL +K++ +KL E K ++ + H+ N+ +T
Sbjct: 614 EEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRE 673
Query: 418 -------------KNKNVE-------------KMRGQMESHLKELERVCDSLTAAERRLH 451
+K+VE K + H KE+E +C + ++
Sbjct: 674 NLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVE 733
Query: 452 ECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQM 511
+ + LQ + D++ ++L + E+L+ L+
Sbjct: 734 DLEHKLQLLSNEIMDKDRCYQDLHAEY-----------------------ESLRDLLKSK 770
Query: 512 DAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQL--EAALEEGRQKVAEEIEKMS 569
DA + N++ + S L F ++ A + + A + + ++ R + E ++
Sbjct: 771 DA------SLVTNEDH--QRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSP 822
Query: 570 SRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNES 627
+ LQ ++ LE L E Q Q+ + + + E++ +L K+E ++S
Sbjct: 823 KNSAILQNRVDSLEFSL----ESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQS 876
Score = 69.3 bits (168), Expect = 1e-11
Identities = 101/560 (18%), Positives = 238/560 (42%), Gaps = 78/560 (13%)
Query: 127 DNLSSMLLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEK----------ANTLKAN 176
+ L + L+ + + E + LKK+ +++ + L Q +K N + N
Sbjct: 10 EGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKREN 69
Query: 177 R----FSQSVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMK 232
+ +S++ +++ ++ +E++ + + + S + +I K + + K+E +
Sbjct: 70 QRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQ 129
Query: 233 EASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIV 292
+A++ V+L + K T + S+ D + K ++ + ++ + +
Sbjct: 130 QAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQ 189
Query: 293 IEKTELEVQIETMKKQIINLLE--------DLKKMEDH-GKNSCEEILRKVHSIEY---- 339
+K + TM + I + +K H NS +R+ S Y
Sbjct: 190 AKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGE 249
Query: 340 -----ENETLNL----------ENTKLKTTLAALKDEVVSVENELSELQ-EVEKKQKTLI 383
TL + +N+ L LK + + N+++EL+ ++ +K +
Sbjct: 250 QEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEM- 308
Query: 384 EMYKTQVQKLQEAA-EIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDS 442
K QV K QE ++ K++ E + K K + K R ++ + ++
Sbjct: 309 ---KGQVNKFQELQLQLEKAKVELI---------EKEKVLNKCRDELVRTTAQYDQASTK 356
Query: 443 LTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCE 502
TA E++L + E L C + ++ + ++E+ Q +
Sbjct: 357 YTALEQKLKKLTEDLSCQRQNAESARCSLEQ---------------KIKEKEKEFQEELS 401
Query: 503 NLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKV- 561
Q+ + +D E +++ +L + + K+ + + + + T++ +QLE LEE +QK+
Sbjct: 402 RQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLC 461
Query: 562 -AEEIEKMSS-RESALQIKILDLETE---LRKKNEEQNQLVCKMNSKAQHQEVCLKEVQN 616
AE+ + S +E+ L+ + +++ E L+ +E++ + VC + ++ ++ + CL + QN
Sbjct: 462 RAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQN 521
Query: 617 SLEKSENQNESIKNYLQFLK 636
E+ + +N S + L+ L+
Sbjct: 522 FAEEMKAKNTSQETMLRDLQ 541
Score = 63.9 bits (154), Expect = 4e-10
Identities = 107/562 (19%), Positives = 230/562 (40%), Gaps = 63/562 (11%)
Query: 41 QDILNEKTELEATLKEAELVTHSVEL-------LLPLFKDTIEKINFENANLSALNLKIS 93
Q++ LE +LKE +L++ ++ L ++ L K IE++ EN L +N ++
Sbjct: 928 QELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLN 987
Query: 94 EQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESENTNLKKKVFE 153
++K LI++ ++F + E + + + + L +LL+ + + +L +K
Sbjct: 988 QEKMNLIQKSESFANYIDEREKSISELSDQYKQEKL--ILLQRCEETGNAYEDLSQKYKA 1045
Query: 154 KEAHIQELSCLFQSEKANTLKANR------FSQSVKVVHERLQIQIHKREAENDKLKEYV 207
+ +L CL + +L NR ++ H+ ++ E N L
Sbjct: 1046 AQEKNSKLECLL--NECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNL---- 1099
Query: 208 KSLETKIAKWNLQSRMNKNEAIVMKEAS--RQKTVALKKASKVYKQRLDHFTGAIEKLTS 265
LE + + L+S M N+ EA +Q+ + LK+ ++ ++ E+L
Sbjct: 1100 -MLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMK 1158
Query: 266 QIRDQ-EAKLSETISASNAWKSHYE-------KIVIEKTELEVQIETMKKQIINL----- 312
++ + E + E+ N+ K K ++ E+ +++ Q++ L
Sbjct: 1159 VMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLR 1218
Query: 313 LEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTK------LKTTLAALKDEVVSVE 366
++LK E + C + ++ +I + ET NL++ + LK +++ +S
Sbjct: 1219 NKELKLQESEKEKEC--LQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGP 1276
Query: 367 NELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMR 426
+ELS Q + ++ ++ +L++ EI+++ L+ + N KM
Sbjct: 1277 HELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMA 1336
Query: 427 GQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLT 486
++ L E++ + D L E + G+ +++H + ++ LT
Sbjct: 1337 EEVGKLLNEVKILNDDSGLLHGELVEDIPGGEF--GEQPNEQHPVSLAPLDESNSYEHLT 1394
Query: 487 KLSLEEENCLIQLKCENLQQKLEQMDAENKELE----------KKLANQEECLKHSNLKF 536
E +Q+ LQ+K + +E+K L +L + LK NL
Sbjct: 1395 LSDKE-----VQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVL 1449
Query: 537 KEKSAEYTA-LARQLEAALEEG 557
+ L ++++ LEEG
Sbjct: 1450 STNLRNFQGDLVKEMQLGLEEG 1471
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 114 bits (286), Expect = 2e-25
Identities = 126/629 (20%), Positives = 270/629 (42%), Gaps = 63/629 (10%)
Query: 27 LPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLS 86
L + E H + + + N E+ A + +T + L + T++ + E ++
Sbjct: 965 LTKVEKEKHAT--ENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVN 1022
Query: 87 AL---NLKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESE 143
L N K+ +Q + L L+ K ++ LE RK + GD M E++ D E++
Sbjct: 1023 GLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLE----GD--LKMSQESIMDLEND 1076
Query: 144 NTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKL 203
+++K+ +KE + +L E+ ++L+ + + ++ E L+ +I K+
Sbjct: 1077 KQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKI 1136
Query: 204 KEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKL 263
++ L ++ + + + E ++++ +K + ++ L
Sbjct: 1137 EKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATL 1196
Query: 264 TSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHG 323
+ D A+L E I K EK EK+EL+++I+ M I E L K + +
Sbjct: 1197 RKKQADSVAELGEQIDNLQRVKQKLEK---EKSELKMEIDDMASNI----EALSKSKSNI 1249
Query: 324 KNSCEEILRKVHSIEYENET-------LNLENTKLKTTLAALKDEVVSVENELSELQEVE 376
+ +C + + I+ ++E LN++ +L+T L V E+ +S+L + +
Sbjct: 1250 ERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSK 1309
Query: 377 KKQKTLIEMYKTQVQK-------LQEAAEIVKSRCENLLHKNNQITKTK----------N 419
+ +E K Q+++ + A + + C+ L + + + K N
Sbjct: 1310 QALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKAN 1369
Query: 420 KNVEKMRGQMESH-LKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQV 478
V + R + E+ ++ E + ++ +RL E +E+ + KCA E T + LQG+V
Sbjct: 1370 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEV 1429
Query: 479 DGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKE 538
+ +L+ L C +D + + +K LA ++ L S + +
Sbjct: 1430 E---DLMRDLERSHTAC-------------ATLDKKQRNFDKVLAEWKQKLDESQAELEA 1473
Query: 539 KSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRK--KNEEQNQL 596
E +L+ +L + ++V +++E + LQ +I DL ++ + KN ++ +
Sbjct: 1474 AQKESRSLSTEL-FKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEK 1532
Query: 597 VCKM-NSKAQHQEVCLKEVQNSLEKSENQ 624
K+ + +V L+EV+ SLE E++
Sbjct: 1533 TKKLVEQEKSDLQVALEEVEGSLEHEESK 1561
Score = 67.4 bits (163), Expect = 4e-11
Identities = 89/453 (19%), Positives = 203/453 (44%), Gaps = 52/453 (11%)
Query: 202 KLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIE 261
K+K +KS E + ++ + + + + +R+K + K S + E
Sbjct: 839 KIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQ-----------E 887
Query: 262 KLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMED 321
K Q++ Q SET + +A + E ++ K LE ++ K++ LE+ ++M
Sbjct: 888 KNDLQLQVQ----SETENLMDA-EERCEGLIKSKILLEAKV----KELTERLEEEEEMNS 938
Query: 322 HGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQE----VEK 377
+ K S++ + + L L TK++ A +++V ++ E++ L+E + K
Sbjct: 939 ELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTK 998
Query: 378 KQKTLIEMYKTQVQKLQEAAEIVKS--RCENLLHKNNQITKTKNKNVEKMRGQMESHLKE 435
++K+L E ++ + LQ + V + L + + + +K+R +E ++
Sbjct: 999 EKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRK 1058
Query: 436 LERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGN--HNLLTKLSLEEE 493
LE L ++ + + + Q + K +E + +LQ ++D H+L + ++E
Sbjct: 1059 LE---GDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKE- 1114
Query: 494 NCLIQLKCENLQQKLE-------QMDAENKELEKKLANQEECLKHSN-------LKFKEK 539
+Q + E L++++E +++ + +L ++L E L+ ++ K++
Sbjct: 1115 ---LQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKR 1171
Query: 540 SAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCK 599
AE+ + R LE A + A +K + + L +I +L+ +K +E+++L +
Sbjct: 1172 EAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKME 1231
Query: 600 MNSKAQHQEVCLK---EVQNSLEKSENQNESIK 629
++ A + E K ++ + E+Q IK
Sbjct: 1232 IDDMASNIEALSKSKSNIERTCRTVEDQFSEIK 1264
Score = 66.6 bits (161), Expect = 7e-11
Identities = 119/654 (18%), Positives = 258/654 (39%), Gaps = 83/654 (12%)
Query: 3 KAVNDGSHSEELFCH----LKTISEKEDLPRCTSESHLSCLKQDILNEKTELEATL---- 54
KA N +H+ + H L+ E+E + + LS ++ +T+ E
Sbjct: 1328 KAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRT 1387
Query: 55 KEAELVTHSVELLLPLFKDTIEKINFENANLSALNLKISEQKEILIKELDTFKSVKLALE 114
+E E + L ++ E N + A+L ++ + E L+++L+ + L+
Sbjct: 1388 EELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLD 1447
Query: 115 HLLRKRDYKQTGDNLSSMLLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLK 174
R N +L E K+K+ E +A ++ +++ +L
Sbjct: 1448 KKQR---------NFDKVLAE-----------WKQKLDESQAELEAAQ-----KESRSLS 1482
Query: 175 ANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEA 234
F ++ +E + Q+ EN L+E + L +IA ++ N EA
Sbjct: 1483 TELFK--MRNAYEEVVDQLETLRRENKNLQEEISDLTEQIA----ETGKNLQEA------ 1530
Query: 235 SRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIE 294
+K K+ +Q A+E++ + +E+K+ + KS ++ VIE
Sbjct: 1531 --------EKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIE 1582
Query: 295 KTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVH--------SIEYENETLNL 346
K E Q++ ++ L+ + E +N + +K+ + + N +
Sbjct: 1583 KDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAE 1642
Query: 347 ENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCEN 406
L+T LKD + +++ L +++ K+Q ++E + + E ++ + E
Sbjct: 1643 TQKHLRTVQGQLKDSQLHLDDALRSNEDL-KEQLAIVERRNGLLLEELEEMKVALEQTER 1701
Query: 407 LLHKNNQITKTKNKNVEKMRGQMESHL---KELER-VCDSLTAAERRLHECQESLQCCKG 462
+ Q + V+ + Q S + K+LE + E + E + + + K
Sbjct: 1702 TRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKK 1761
Query: 463 KCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMD----AENKEL 518
D EL+ + D T LE ++ ++LQ +L++ + K+
Sbjct: 1762 AITDAAMMAEELKKEQD------TSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQ 1815
Query: 519 EKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEE---IEKMSSRESAL 575
+KL N+ L++ +++ AE A + E ++E + E+ I ++ L
Sbjct: 1816 IQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKL 1875
Query: 576 QIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIK 629
Q K+ + + + E+ N + + + QH+ L+E + +E+Q ++
Sbjct: 1876 QAKVKSYKRQAEEAEEQANTQLSRCR-RVQHE---LEEAAERADIAESQVNKLR 1925
Score = 43.5 bits (101), Expect = 6e-04
Identities = 56/270 (20%), Positives = 122/270 (45%), Gaps = 42/270 (15%)
Query: 374 EVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHL 433
E EK+ T+ E ++ ++L + ++R + L K + + KN +++ + E+ L
Sbjct: 848 EAEKEMATMKEDFERTKEELARS----EARRKELEEKMVSLLQEKNDLQLQVQSETEN-L 902
Query: 434 KELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEE 493
+ E C+ L ++ L E ++EL +++ + ++L ++
Sbjct: 903 MDAEERCEGLIKSKILL-----------------EAKVKELTERLEEEEEMNSELVAKKR 945
Query: 494 NCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQL--- 550
N ++ KC +L++ ++ ++ ++EK+ E K K S E TAL +
Sbjct: 946 N--LEDKCSSLKRDIDDLELTLTKVEKEKHATEN-------KVKNLSEEMTALEENISKL 996
Query: 551 ---EAALEEGRQKVAEEIEKMSSRESALQIKI---LDLET-ELRKKNEEQNQLVCKMNSK 603
+ +L+E Q+ ++++ + + L IKI L+ +T +L E++ +L +
Sbjct: 997 TKEKKSLQEAHQQTLDDLQVEEDKVNGL-IKINAKLEQQTDDLEGSLEQEKKLRADLERA 1055
Query: 604 AQHQEVCLKEVQNSLEKSENQNESIKNYLQ 633
+ E LK Q S+ EN + I+ L+
Sbjct: 1056 KRKLEGDLKMSQESIMDLENDKQQIEEKLK 1085
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 104 bits (259), Expect = 3e-22
Identities = 134/646 (20%), Positives = 287/646 (44%), Gaps = 65/646 (10%)
Query: 23 EKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFEN 82
+K L + T+E+ + L+ +IL + KE +L+ + L + EK
Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK--- 1023
Query: 83 ANLSALNLKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNES 142
NL+ K+ + E +I EL+ + L K K GD +S E + D ++
Sbjct: 1024 -NLT----KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD--ASDFHEQIADLQA 1076
Query: 143 ENTNLKKKVFEKEAHIQELSCLFQSE---KANTLKANRFSQS-VKVVHERLQIQI---HK 195
+ LK ++ +KE +Q E K N LK R + + + E L + +K
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1136
Query: 196 REAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKA---------S 246
E + L E +++L+T++ L S + E +E Q+ LKKA +
Sbjct: 1137 AEKQKRDLGEELEALKTELED-TLDSTATQQELRAKRE---QEVTVLKKALDEETRSHEA 1192
Query: 247 KVYKQRLDHFTGAIEKLTSQIRDQEA------KLSETISASNAWKSHYEKIVIEKTELEV 300
+V + R H A+E+LT Q+ + K +T+ NA + +++ + +
Sbjct: 1193 QVQEMRQKH-AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ--- 1248
Query: 301 QIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKD 360
++E KK++ +++L+ G+ + E+ KVH ++ E E++ + + L
Sbjct: 1249 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1308
Query: 361 EVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNK 420
+V S+ ++L + QE+ +++ T++++L+E ++ ++ L + + + +
Sbjct: 1309 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE----RNSLQDQLDEEMEAKQNLER 1364
Query: 421 NVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQ-------EHTIRE 473
++ + Q+ K+L+ ++ A E Q+ ++ + ++ E T
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1424
Query: 474 LQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSN 533
LQ ++D + L+ + L+ E Q+K +Q+ AE K + K A++ + +
Sbjct: 1425 LQQELDD-----LVVDLDNQRQLVS-NLEKKQRKFDQLLAEEKNISSKYADERD---RAE 1475
Query: 534 LKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQ 593
+ +EK + +LAR LE ALE EE+E+ + A ++ + ++ K E
Sbjct: 1476 AEAREKETKALSLARALEEALE-----AKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1530
Query: 594 NQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSY 639
+ + ++ + + L+E+++ L+ +E+ ++ +Q LK +
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1576
Score = 93.2 bits (230), Expect = 7e-19
Identities = 160/727 (22%), Positives = 296/727 (40%), Gaps = 136/727 (18%)
Query: 19 KTISEKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKI 78
K EKE+ L KQ++ ++K +LEA ++E + E D + K+
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1285
Query: 79 NFENANLSALNLKISEQKEI-LIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENL 137
E +++ + L +E K I L K++ + S + LL++ ++ N+S+ L +
Sbjct: 1286 QNEVESVTGM-LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL--NVSTKLRQLE 1342
Query: 138 TDNESENTNLKKKVFEK---EAHIQELSCLFQSEK------ANTLKA-----NRFSQSVK 183
+ S L +++ K E HI L+ K A+T++A RF + ++
Sbjct: 1343 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1402
Query: 184 VVHE-----------------RLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKN 226
+ + RLQ ++ + D ++ V +LE K K++ KN
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1462
Query: 227 -EAIVMKEASRQKTVALKKASKVYK--QRLDHFTGAIEKLTSQIRDQEAKLSETISASNA 283
+ E R + A +K +K + L+ A E+L + +A++ + +S+ +
Sbjct: 1463 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1522
Query: 284 WKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMED---------------------- 321
+ ++ K LE Q+E MK Q+ L ++L+ ED
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1582
Query: 322 ---HGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQ-EVEK 377
+ ++ R++H EYE E LE+ + + LAA + +E +L +L+ + +
Sbjct: 1583 RDEQNEEKRRQLQRQLH--EYETE---LEDERKQRALAAAAKK--KLEGDLKDLELQADS 1635
Query: 378 KQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELE 437
K E K Q++KLQ + + E+ ++I T +N EK +E+ L +L+
Sbjct: 1636 AIKGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFATAKEN-EKKAKSLEADLMQLQ 1693
Query: 438 RVCDSLTAAERRLHEC---------------------QESLQCCKGKCADQEHTIRELQG 476
+ L AAER + Q+ + + + A E + E QG
Sbjct: 1694 ---EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1750
Query: 477 QVDGNHNLLTKLSLEEENCLIQLKCE-NLQQKLE----QMDAENKELEKKLANQEECLKH 531
++ + + K + + E +L E + QK E Q++ +NKEL KL E +K
Sbjct: 1751 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1810
Query: 532 SNLKFKEKSAEYTALARQLEAALE-EGRQKVA---------------------------- 562
KFK A A QLE +E E R+K A
Sbjct: 1811 ---KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1867
Query: 563 --EEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEK 620
E+ EK ++R L+ ++ + E E ++ N + +L +++ + E +EV K
Sbjct: 1868 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927
Query: 621 SENQNES 627
NE+
Sbjct: 1928 LRRGNET 1934
Score = 80.5 bits (197), Expect = 4e-15
Identities = 135/661 (20%), Positives = 270/661 (40%), Gaps = 111/661 (16%)
Query: 47 KTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSALNLKISEQKEILIKELDTF 106
K L+ T +E E+ EL K+ +K E L + +++E+K +L ++L
Sbjct: 842 KPLLQVTRQEEEMQAKEDELQKT--KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 899
Query: 107 KSVKLALEHL-LRKRDYKQTGDNLSSMLLENLTDNESENTNLKKKVFEKEAHIQELSCLF 165
+ E + +R KQ + + + L + E L+ + + + +L
Sbjct: 900 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 959
Query: 166 QSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDK---------------------LK 204
+ E+A ++LQ++ EA+ K L+
Sbjct: 960 EEEEA--------------ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE 1005
Query: 205 EYVKSLETKIAK-----WNLQSRMNKNEAIV--------MKEASRQKTVALKKASKVYKQ 251
E + L T +A+ NL NK+E+++ +E SRQ+ L+K + +
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE---LEKLKRKLEG 1062
Query: 252 RLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIIN 311
F I L +QI + + +L++ A + + + +K +I ++ I +
Sbjct: 1063 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1122
Query: 312 LLEDLKKMEDHGKNSCEEILR----KVHSIEYENETLNLENTKLKTTLAALKDEVVSVEN 367
L EDL E +N E+ R ++ +++ E E L++T + L A +++ V+V
Sbjct: 1123 LQEDLDS-ERAARNKAEKQKRDLGEELEALKTELED-TLDSTATQQELRAKREQEVTVLK 1180
Query: 368 ELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVK--SRCENLLHKNNQITKTKN------ 419
+ + +E + + EM + Q ++E E ++ R + L KN Q + +N
Sbjct: 1181 KALD-EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Query: 420 --------KNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQC-----------C 460
+ VE + ++E+ ++EL+ C A L++ LQ
Sbjct: 1240 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1299
Query: 461 KGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQM-DAENKELE 519
+GK + L Q+ LL + + ++ N + K L+++ + D ++E+E
Sbjct: 1300 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN--VSTKLRQLEEERNSLQDQLDEEME 1357
Query: 520 KKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIE------------- 566
K N E + N++ + + A +E ALEEG+++ +EIE
Sbjct: 1358 AK-QNLERHISTLNIQLSDSKKKLQDFASTVE-ALEEGKKRFQKEIENLTQQYEEKAAAY 1415
Query: 567 -KMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQN 625
K+ ++ LQ ++ DL +L + Q QLV + K + + L E +N K ++
Sbjct: 1416 DKLEKTKNRLQQELDDLVVDL----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1471
Query: 626 E 626
+
Sbjct: 1472 D 1472
Score = 76.6 bits (187), Expect = 6e-14
Identities = 90/431 (20%), Positives = 185/431 (42%), Gaps = 61/431 (14%)
Query: 217 WNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSE 276
W L +++ + +E Q + +K +Q+ ++ +E+ SQ+ +++ L E
Sbjct: 835 WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE 894
Query: 277 TISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLED----LKKMEDHG-------KN 325
+ A ++ E E+ V++ K+++ +L + L++ ED G K
Sbjct: 895 QLQAET-------ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 947
Query: 326 SCEEILRKVHSIEYE---NETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTL 382
+++L +E E + L LE + + L+DE++ ++++ ++L K++K L
Sbjct: 948 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL---SKERKLL 1004
Query: 383 IEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDS 442
E L E E K +TK KNK+ E M ++E LK+ E+
Sbjct: 1005 EERISDLTTNLAEEEE-----------KAKNLTKLKNKH-ESMISELEVRLKKEEKSRQE 1052
Query: 443 LTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCE 502
L +R+L +G +D I +LQ Q+ L K E + L +L E
Sbjct: 1053 LEKLKRKL----------EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1102
Query: 503 -----NLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEG 557
N +K+ +++ +L++ L ++ + + ++ E AL +LE L+
Sbjct: 1103 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS- 1161
Query: 558 RQKVAEEIEKMSSRESALQIKILDLET--------ELRKKNEEQNQLVCKMNSKAQHQEV 609
+E+ +E + K LD ET E+R+K+ + + + + + + +
Sbjct: 1162 -TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220
Query: 610 CLKEVQNSLEK 620
L + + +LEK
Sbjct: 1221 NLDKNKQTLEK 1231
Score = 40.4 bits (93), Expect = 0.005
Identities = 40/188 (21%), Positives = 80/188 (42%), Gaps = 32/188 (17%)
Query: 460 CKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQ-------------- 505
C+G A + R+ Q LT + + + NC LK N Q
Sbjct: 797 CRGYLARKAFAKRQQQ---------LTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQV 847
Query: 506 -QKLEQMDAENKELEKKLANQEEC---LKHSNLKFKEKSAEYTALARQLEAALEEGRQKV 561
++ E+M A+ EL+K Q++ LK K + + E L QL+A E +
Sbjct: 848 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE-----L 902
Query: 562 AEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKS 621
E E+M R +A + ++ ++ E+ + EE+ ++ ++ + + +++ LE+
Sbjct: 903 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 622 ENQNESIK 629
E + ++
Sbjct: 963 EAARQKLQ 970
Score = 35.8 bits (81), Expect = 0.13
Identities = 30/139 (21%), Positives = 62/139 (44%), Gaps = 1/139 (0%)
Query: 498 QLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEG 557
Q K EN ++LEQ ++ E + L Q + + +E A ++LE L E
Sbjct: 868 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 927
Query: 558 RQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNS 617
++ EE E + A + K+ +L ++ EE+ K+ + E +K++++
Sbjct: 928 EARLEEE-EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDE 986
Query: 618 LEKSENQNESIKNYLQFLK 636
+ ++QN + + L+
Sbjct: 987 ILVMDDQNNKLSKERKLLE 1005
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 104 bits (259), Expect = 3e-22
Identities = 134/646 (20%), Positives = 287/646 (44%), Gaps = 65/646 (10%)
Query: 23 EKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFEN 82
+K L + T+E+ + L+ +IL + KE +L+ + L + EK
Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK--- 1030
Query: 83 ANLSALNLKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNES 142
NL+ K+ + E +I EL+ + L K K GD +S E + D ++
Sbjct: 1031 -NLT----KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD--ASDFHEQIADLQA 1083
Query: 143 ENTNLKKKVFEKEAHIQELSCLFQSE---KANTLKANRFSQS-VKVVHERLQIQI---HK 195
+ LK ++ +KE +Q E K N LK R + + + E L + +K
Sbjct: 1084 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1143
Query: 196 REAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKA---------S 246
E + L E +++L+T++ L S + E +E Q+ LKKA +
Sbjct: 1144 AEKQKRDLGEELEALKTELED-TLDSTATQQELRAKRE---QEVTVLKKALDEETRSHEA 1199
Query: 247 KVYKQRLDHFTGAIEKLTSQIRDQEA------KLSETISASNAWKSHYEKIVIEKTELEV 300
+V + R H A+E+LT Q+ + K +T+ NA + +++ + +
Sbjct: 1200 QVQEMRQKH-AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ--- 1255
Query: 301 QIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKD 360
++E KK++ +++L+ G+ + E+ KVH ++ E E++ + + L
Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1315
Query: 361 EVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNK 420
+V S+ ++L + QE+ +++ T++++L+E ++ ++ L + + + +
Sbjct: 1316 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE----RNSLQDQLDEEMEAKQNLER 1371
Query: 421 NVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQ-------EHTIRE 473
++ + Q+ K+L+ ++ A E Q+ ++ + ++ E T
Sbjct: 1372 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431
Query: 474 LQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSN 533
LQ ++D + L+ + L+ E Q+K +Q+ AE K + K A++ + +
Sbjct: 1432 LQQELDD-----LVVDLDNQRQLVS-NLEKKQRKFDQLLAEEKNISSKYADERD---RAE 1482
Query: 534 LKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQ 593
+ +EK + +LAR LE ALE EE+E+ + A ++ + ++ K E
Sbjct: 1483 AEAREKETKALSLARALEEALE-----AKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1537
Query: 594 NQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSY 639
+ + ++ + + L+E+++ L+ +E+ ++ +Q LK +
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583
Score = 93.2 bits (230), Expect = 7e-19
Identities = 160/727 (22%), Positives = 296/727 (40%), Gaps = 136/727 (18%)
Query: 19 KTISEKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKI 78
K EKE+ L KQ++ ++K +LEA ++E + E D + K+
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1292
Query: 79 NFENANLSALNLKISEQKEI-LIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENL 137
E +++ + L +E K I L K++ + S + LL++ ++ N+S+ L +
Sbjct: 1293 QNEVESVTGM-LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL--NVSTKLRQLE 1349
Query: 138 TDNESENTNLKKKVFEK---EAHIQELSCLFQSEK------ANTLKA-----NRFSQSVK 183
+ S L +++ K E HI L+ K A+T++A RF + ++
Sbjct: 1350 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409
Query: 184 VVHE-----------------RLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKN 226
+ + RLQ ++ + D ++ V +LE K K++ KN
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1469
Query: 227 -EAIVMKEASRQKTVALKKASKVYK--QRLDHFTGAIEKLTSQIRDQEAKLSETISASNA 283
+ E R + A +K +K + L+ A E+L + +A++ + +S+ +
Sbjct: 1470 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1529
Query: 284 WKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMED---------------------- 321
+ ++ K LE Q+E MK Q+ L ++L+ ED
Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1589
Query: 322 ---HGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQ-EVEK 377
+ ++ R++H EYE E LE+ + + LAA + +E +L +L+ + +
Sbjct: 1590 RDEQNEEKRRQLQRQLH--EYETE---LEDERKQRALAAAAKK--KLEGDLKDLELQADS 1642
Query: 378 KQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELE 437
K E K Q++KLQ + + E+ ++I T +N EK +E+ L +L+
Sbjct: 1643 AIKGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFATAKEN-EKKAKSLEADLMQLQ 1700
Query: 438 RVCDSLTAAERRLHEC---------------------QESLQCCKGKCADQEHTIRELQG 476
+ L AAER + Q+ + + + A E + E QG
Sbjct: 1701 ---EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1757
Query: 477 QVDGNHNLLTKLSLEEENCLIQLKCE-NLQQKLE----QMDAENKELEKKLANQEECLKH 531
++ + + K + + E +L E + QK E Q++ +NKEL KL E +K
Sbjct: 1758 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1817
Query: 532 SNLKFKEKSAEYTALARQLEAALE-EGRQKVA---------------------------- 562
KFK A A QLE +E E R+K A
Sbjct: 1818 ---KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1874
Query: 563 --EEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEK 620
E+ EK ++R L+ ++ + E E ++ N + +L +++ + E +EV K
Sbjct: 1875 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934
Query: 621 SENQNES 627
NE+
Sbjct: 1935 LRRGNET 1941
Score = 80.5 bits (197), Expect = 4e-15
Identities = 135/661 (20%), Positives = 270/661 (40%), Gaps = 111/661 (16%)
Query: 47 KTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSALNLKISEQKEILIKELDTF 106
K L+ T +E E+ EL K+ +K E L + +++E+K +L ++L
Sbjct: 849 KPLLQVTRQEEEMQAKEDELQKT--KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 906
Query: 107 KSVKLALEHL-LRKRDYKQTGDNLSSMLLENLTDNESENTNLKKKVFEKEAHIQELSCLF 165
+ E + +R KQ + + + L + E L+ + + + +L
Sbjct: 907 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 966
Query: 166 QSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDK---------------------LK 204
+ E+A ++LQ++ EA+ K L+
Sbjct: 967 EEEEA--------------ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE 1012
Query: 205 EYVKSLETKIAK-----WNLQSRMNKNEAIV--------MKEASRQKTVALKKASKVYKQ 251
E + L T +A+ NL NK+E+++ +E SRQ+ L+K + +
Sbjct: 1013 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE---LEKLKRKLEG 1069
Query: 252 RLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIIN 311
F I L +QI + + +L++ A + + + +K +I ++ I +
Sbjct: 1070 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1129
Query: 312 LLEDLKKMEDHGKNSCEEILR----KVHSIEYENETLNLENTKLKTTLAALKDEVVSVEN 367
L EDL E +N E+ R ++ +++ E E L++T + L A +++ V+V
Sbjct: 1130 LQEDLDS-ERAARNKAEKQKRDLGEELEALKTELED-TLDSTATQQELRAKREQEVTVLK 1187
Query: 368 ELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVK--SRCENLLHKNNQITKTKN------ 419
+ + +E + + EM + Q ++E E ++ R + L KN Q + +N
Sbjct: 1188 KALD-EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 420 --------KNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQC-----------C 460
+ VE + ++E+ ++EL+ C A L++ LQ
Sbjct: 1247 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1306
Query: 461 KGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQM-DAENKELE 519
+GK + L Q+ LL + + ++ N + K L+++ + D ++E+E
Sbjct: 1307 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN--VSTKLRQLEEERNSLQDQLDEEME 1364
Query: 520 KKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIE------------- 566
K N E + N++ + + A +E ALEEG+++ +EIE
Sbjct: 1365 AK-QNLERHISTLNIQLSDSKKKLQDFASTVE-ALEEGKKRFQKEIENLTQQYEEKAAAY 1422
Query: 567 -KMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQN 625
K+ ++ LQ ++ DL +L + Q QLV + K + + L E +N K ++
Sbjct: 1423 DKLEKTKNRLQQELDDLVVDL----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1478
Query: 626 E 626
+
Sbjct: 1479 D 1479
Score = 76.6 bits (187), Expect = 6e-14
Identities = 90/431 (20%), Positives = 185/431 (42%), Gaps = 61/431 (14%)
Query: 217 WNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSE 276
W L +++ + +E Q + +K +Q+ ++ +E+ SQ+ +++ L E
Sbjct: 842 WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE 901
Query: 277 TISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLED----LKKMEDHG-------KN 325
+ A ++ E E+ V++ K+++ +L + L++ ED G K
Sbjct: 902 QLQAET-------ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 954
Query: 326 SCEEILRKVHSIEYE---NETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTL 382
+++L +E E + L LE + + L+DE++ ++++ ++L K++K L
Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL---SKERKLL 1011
Query: 383 IEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDS 442
E L E E K +TK KNK+ E M ++E LK+ E+
Sbjct: 1012 EERISDLTTNLAEEEE-----------KAKNLTKLKNKH-ESMISELEVRLKKEEKSRQE 1059
Query: 443 LTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCE 502
L +R+L +G +D I +LQ Q+ L K E + L +L E
Sbjct: 1060 LEKLKRKL----------EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1109
Query: 503 -----NLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEG 557
N +K+ +++ +L++ L ++ + + ++ E AL +LE L+
Sbjct: 1110 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS- 1168
Query: 558 RQKVAEEIEKMSSRESALQIKILDLET--------ELRKKNEEQNQLVCKMNSKAQHQEV 609
+E+ +E + K LD ET E+R+K+ + + + + + + +
Sbjct: 1169 -TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1227
Query: 610 CLKEVQNSLEK 620
L + + +LEK
Sbjct: 1228 NLDKNKQTLEK 1238
Score = 40.4 bits (93), Expect = 0.005
Identities = 40/188 (21%), Positives = 80/188 (42%), Gaps = 32/188 (17%)
Query: 460 CKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQ-------------- 505
C+G A + R+ Q LT + + + NC LK N Q
Sbjct: 804 CRGYLARKAFAKRQQQ---------LTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQV 854
Query: 506 -QKLEQMDAENKELEKKLANQEEC---LKHSNLKFKEKSAEYTALARQLEAALEEGRQKV 561
++ E+M A+ EL+K Q++ LK K + + E L QL+A E +
Sbjct: 855 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE-----L 909
Query: 562 AEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKS 621
E E+M R +A + ++ ++ E+ + EE+ ++ ++ + + +++ LE+
Sbjct: 910 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 622 ENQNESIK 629
E + ++
Sbjct: 970 EAARQKLQ 977
Score = 35.8 bits (81), Expect = 0.13
Identities = 30/139 (21%), Positives = 62/139 (44%), Gaps = 1/139 (0%)
Query: 498 QLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEG 557
Q K EN ++LEQ ++ E + L Q + + +E A ++LE L E
Sbjct: 875 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 934
Query: 558 RQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNS 617
++ EE E + A + K+ +L ++ EE+ K+ + E +K++++
Sbjct: 935 EARLEEE-EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDE 993
Query: 618 LEKSENQNESIKNYLQFLK 636
+ ++QN + + L+
Sbjct: 994 ILVMDDQNNKLSKERKLLE 1012
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 104 bits (259), Expect = 3e-22
Identities = 134/646 (20%), Positives = 287/646 (44%), Gaps = 65/646 (10%)
Query: 23 EKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFEN 82
+K L + T+E+ + L+ +IL + KE +L+ + L + EK
Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK--- 1030
Query: 83 ANLSALNLKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNES 142
NL+ K+ + E +I EL+ + L K K GD +S E + D ++
Sbjct: 1031 -NLT----KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD--ASDFHEQIADLQA 1083
Query: 143 ENTNLKKKVFEKEAHIQELSCLFQSE---KANTLKANRFSQS-VKVVHERLQIQI---HK 195
+ LK ++ +KE +Q E K N LK R + + + E L + +K
Sbjct: 1084 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1143
Query: 196 REAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKA---------S 246
E + L E +++L+T++ L S + E +E Q+ LKKA +
Sbjct: 1144 AEKQKRDLGEELEALKTELED-TLDSTATQQELRAKRE---QEVTVLKKALDEETRSHEA 1199
Query: 247 KVYKQRLDHFTGAIEKLTSQIRDQEA------KLSETISASNAWKSHYEKIVIEKTELEV 300
+V + R H A+E+LT Q+ + K +T+ NA + +++ + +
Sbjct: 1200 QVQEMRQKH-AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ--- 1255
Query: 301 QIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKD 360
++E KK++ +++L+ G+ + E+ KVH ++ E E++ + + L
Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1315
Query: 361 EVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNK 420
+V S+ ++L + QE+ +++ T++++L+E ++ ++ L + + + +
Sbjct: 1316 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE----RNSLQDQLDEEMEAKQNLER 1371
Query: 421 NVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQ-------EHTIRE 473
++ + Q+ K+L+ ++ A E Q+ ++ + ++ E T
Sbjct: 1372 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431
Query: 474 LQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSN 533
LQ ++D + L+ + L+ E Q+K +Q+ AE K + K A++ + +
Sbjct: 1432 LQQELDD-----LVVDLDNQRQLVS-NLEKKQRKFDQLLAEEKNISSKYADERD---RAE 1482
Query: 534 LKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQ 593
+ +EK + +LAR LE ALE EE+E+ + A ++ + ++ K E
Sbjct: 1483 AEAREKETKALSLARALEEALE-----AKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1537
Query: 594 NQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSY 639
+ + ++ + + L+E+++ L+ +E+ ++ +Q LK +
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583
Score = 100 bits (249), Expect = 4e-21
Identities = 155/697 (22%), Positives = 296/697 (42%), Gaps = 113/697 (16%)
Query: 19 KTISEKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKI 78
K EKE+ L KQ++ ++K +LEA ++E + E D + K+
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1292
Query: 79 NFENANLSALNLKISEQKEI-LIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENL 137
E +++ + L +E K I L K++ + S + LL++ ++ N+S+ L +
Sbjct: 1293 QNEVESVTGM-LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL--NVSTKLRQLE 1349
Query: 138 TDNESENTNLKKKVFEK---EAHIQELSCLFQSEK------ANTLKA-----NRFSQSVK 183
+ S L +++ K E HI L+ K A+T++A RF + ++
Sbjct: 1350 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409
Query: 184 VVHE-----------------RLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKN 226
+ + RLQ ++ + D ++ V +LE K K++ KN
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1469
Query: 227 -EAIVMKEASRQKTVALKKASKVYK--QRLDHFTGAIEKLTSQIRDQEAKLSETISASNA 283
+ E R + A +K +K + L+ A E+L + +A++ + +S+ +
Sbjct: 1470 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1529
Query: 284 WKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMED---------------------- 321
+ ++ K LE Q+E MK Q+ L ++L+ ED
Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1589
Query: 322 ---HGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQ-EVEK 377
+ ++ R++H EYE E LE+ + + LAA + +E +L +L+ + +
Sbjct: 1590 RDEQNEEKRRQLQRQLH--EYETE---LEDERKQRALAAAAKK--KLEGDLKDLELQADS 1642
Query: 378 KQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELE 437
K E K Q++KLQ + + E+ ++I T +N EK +E+ L +L+
Sbjct: 1643 AIKGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFATAKEN-EKKAKSLEADLMQLQ 1700
Query: 438 RVCDSLTAAERRLHEC---------------------QESLQCCKGKCADQEHTIRELQG 476
+ L AAER + Q+ + + + A E + E QG
Sbjct: 1701 ---EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1757
Query: 477 QVDGNHNLLTKLSLEEENCLIQLKCE-NLQQKLE----QMDAENKELEKKLANQEECLKH 531
++ + + K + + E +L E + QK E Q++ +NKEL KL E +K
Sbjct: 1758 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1817
Query: 532 SNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNE 591
KFK A A QLE +E+ ++ + + ++ L+ +L +E E RK E
Sbjct: 1818 ---KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE-RKMAE 1873
Query: 592 EQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESI 628
+ + K N++ +K+++ LE++E +++ I
Sbjct: 1874 QYKEQAEKGNAR-------VKQLKRQLEEAEEESQRI 1903
Score = 80.5 bits (197), Expect = 4e-15
Identities = 135/661 (20%), Positives = 270/661 (40%), Gaps = 111/661 (16%)
Query: 47 KTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSALNLKISEQKEILIKELDTF 106
K L+ T +E E+ EL K+ +K E L + +++E+K +L ++L
Sbjct: 849 KPLLQVTRQEEEMQAKEDELQKT--KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 906
Query: 107 KSVKLALEHL-LRKRDYKQTGDNLSSMLLENLTDNESENTNLKKKVFEKEAHIQELSCLF 165
+ E + +R KQ + + + L + E L+ + + + +L
Sbjct: 907 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 966
Query: 166 QSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDK---------------------LK 204
+ E+A ++LQ++ EA+ K L+
Sbjct: 967 EEEEA--------------ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE 1012
Query: 205 EYVKSLETKIAK-----WNLQSRMNKNEAIV--------MKEASRQKTVALKKASKVYKQ 251
E + L T +A+ NL NK+E+++ +E SRQ+ L+K + +
Sbjct: 1013 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE---LEKLKRKLEG 1069
Query: 252 RLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIIN 311
F I L +QI + + +L++ A + + + +K +I ++ I +
Sbjct: 1070 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1129
Query: 312 LLEDLKKMEDHGKNSCEEILR----KVHSIEYENETLNLENTKLKTTLAALKDEVVSVEN 367
L EDL E +N E+ R ++ +++ E E L++T + L A +++ V+V
Sbjct: 1130 LQEDLDS-ERAARNKAEKQKRDLGEELEALKTELED-TLDSTATQQELRAKREQEVTVLK 1187
Query: 368 ELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVK--SRCENLLHKNNQITKTKN------ 419
+ + +E + + EM + Q ++E E ++ R + L KN Q + +N
Sbjct: 1188 KALD-EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 420 --------KNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQC-----------C 460
+ VE + ++E+ ++EL+ C A L++ LQ
Sbjct: 1247 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1306
Query: 461 KGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQM-DAENKELE 519
+GK + L Q+ LL + + ++ N + K L+++ + D ++E+E
Sbjct: 1307 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN--VSTKLRQLEEERNSLQDQLDEEME 1364
Query: 520 KKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIE------------- 566
K N E + N++ + + A +E ALEEG+++ +EIE
Sbjct: 1365 AK-QNLERHISTLNIQLSDSKKKLQDFASTVE-ALEEGKKRFQKEIENLTQQYEEKAAAY 1422
Query: 567 -KMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQN 625
K+ ++ LQ ++ DL +L + Q QLV + K + + L E +N K ++
Sbjct: 1423 DKLEKTKNRLQQELDDLVVDL----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1478
Query: 626 E 626
+
Sbjct: 1479 D 1479
Score = 76.6 bits (187), Expect = 6e-14
Identities = 90/431 (20%), Positives = 185/431 (42%), Gaps = 61/431 (14%)
Query: 217 WNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSE 276
W L +++ + +E Q + +K +Q+ ++ +E+ SQ+ +++ L E
Sbjct: 842 WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE 901
Query: 277 TISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLED----LKKMEDHG-------KN 325
+ A ++ E E+ V++ K+++ +L + L++ ED G K
Sbjct: 902 QLQAET-------ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 954
Query: 326 SCEEILRKVHSIEYE---NETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTL 382
+++L +E E + L LE + + L+DE++ ++++ ++L K++K L
Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL---SKERKLL 1011
Query: 383 IEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDS 442
E L E E K +TK KNK+ E M ++E LK+ E+
Sbjct: 1012 EERISDLTTNLAEEEE-----------KAKNLTKLKNKH-ESMISELEVRLKKEEKSRQE 1059
Query: 443 LTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCE 502
L +R+L +G +D I +LQ Q+ L K E + L +L E
Sbjct: 1060 LEKLKRKL----------EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1109
Query: 503 -----NLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEG 557
N +K+ +++ +L++ L ++ + + ++ E AL +LE L+
Sbjct: 1110 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS- 1168
Query: 558 RQKVAEEIEKMSSRESALQIKILDLET--------ELRKKNEEQNQLVCKMNSKAQHQEV 609
+E+ +E + K LD ET E+R+K+ + + + + + + +
Sbjct: 1169 -TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1227
Query: 610 CLKEVQNSLEK 620
L + + +LEK
Sbjct: 1228 NLDKNKQTLEK 1238
Score = 40.4 bits (93), Expect = 0.005
Identities = 40/188 (21%), Positives = 80/188 (42%), Gaps = 32/188 (17%)
Query: 460 CKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQ-------------- 505
C+G A + R+ Q LT + + + NC LK N Q
Sbjct: 804 CRGYLARKAFAKRQQQ---------LTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQV 854
Query: 506 -QKLEQMDAENKELEKKLANQEEC---LKHSNLKFKEKSAEYTALARQLEAALEEGRQKV 561
++ E+M A+ EL+K Q++ LK K + + E L QL+A E +
Sbjct: 855 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE-----L 909
Query: 562 AEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKS 621
E E+M R +A + ++ ++ E+ + EE+ ++ ++ + + +++ LE+
Sbjct: 910 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 622 ENQNESIK 629
E + ++
Sbjct: 970 EAARQKLQ 977
Score = 35.8 bits (81), Expect = 0.13
Identities = 30/139 (21%), Positives = 62/139 (44%), Gaps = 1/139 (0%)
Query: 498 QLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEG 557
Q K EN ++LEQ ++ E + L Q + + +E A ++LE L E
Sbjct: 875 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 934
Query: 558 RQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNS 617
++ EE E + A + K+ +L ++ EE+ K+ + E +K++++
Sbjct: 935 EARLEEE-EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDE 993
Query: 618 LEKSENQNESIKNYLQFLK 636
+ ++QN + + L+
Sbjct: 994 ILVMDDQNNKLSKERKLLE 1012
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 104 bits (259), Expect = 3e-22
Identities = 134/646 (20%), Positives = 287/646 (44%), Gaps = 65/646 (10%)
Query: 23 EKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFEN 82
+K L + T+E+ + L+ +IL + KE +L+ + L + EK
Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK--- 1023
Query: 83 ANLSALNLKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNES 142
NL+ K+ + E +I EL+ + L K K GD +S E + D ++
Sbjct: 1024 -NLT----KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD--ASDFHEQIADLQA 1076
Query: 143 ENTNLKKKVFEKEAHIQELSCLFQSE---KANTLKANRFSQS-VKVVHERLQIQI---HK 195
+ LK ++ +KE +Q E K N LK R + + + E L + +K
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1136
Query: 196 REAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKA---------S 246
E + L E +++L+T++ L S + E +E Q+ LKKA +
Sbjct: 1137 AEKQKRDLGEELEALKTELED-TLDSTATQQELRAKRE---QEVTVLKKALDEETRSHEA 1192
Query: 247 KVYKQRLDHFTGAIEKLTSQIRDQEA------KLSETISASNAWKSHYEKIVIEKTELEV 300
+V + R H A+E+LT Q+ + K +T+ NA + +++ + +
Sbjct: 1193 QVQEMRQKH-AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ--- 1248
Query: 301 QIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKD 360
++E KK++ +++L+ G+ + E+ KVH ++ E E++ + + L
Sbjct: 1249 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1308
Query: 361 EVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNK 420
+V S+ ++L + QE+ +++ T++++L+E ++ ++ L + + + +
Sbjct: 1309 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE----RNSLQDQLDEEMEAKQNLER 1364
Query: 421 NVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQ-------EHTIRE 473
++ + Q+ K+L+ ++ A E Q+ ++ + ++ E T
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1424
Query: 474 LQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSN 533
LQ ++D + L+ + L+ E Q+K +Q+ AE K + K A++ + +
Sbjct: 1425 LQQELDD-----LVVDLDNQRQLVS-NLEKKQRKFDQLLAEEKNISSKYADERD---RAE 1475
Query: 534 LKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQ 593
+ +EK + +LAR LE ALE EE+E+ + A ++ + ++ K E
Sbjct: 1476 AEAREKETKALSLARALEEALE-----AKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1530
Query: 594 NQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSY 639
+ + ++ + + L+E+++ L+ +E+ ++ +Q LK +
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1576
Score = 100 bits (249), Expect = 4e-21
Identities = 155/697 (22%), Positives = 296/697 (42%), Gaps = 113/697 (16%)
Query: 19 KTISEKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKI 78
K EKE+ L KQ++ ++K +LEA ++E + E D + K+
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1285
Query: 79 NFENANLSALNLKISEQKEI-LIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENL 137
E +++ + L +E K I L K++ + S + LL++ ++ N+S+ L +
Sbjct: 1286 QNEVESVTGM-LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL--NVSTKLRQLE 1342
Query: 138 TDNESENTNLKKKVFEK---EAHIQELSCLFQSEK------ANTLKA-----NRFSQSVK 183
+ S L +++ K E HI L+ K A+T++A RF + ++
Sbjct: 1343 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1402
Query: 184 VVHE-----------------RLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKN 226
+ + RLQ ++ + D ++ V +LE K K++ KN
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1462
Query: 227 -EAIVMKEASRQKTVALKKASKVYK--QRLDHFTGAIEKLTSQIRDQEAKLSETISASNA 283
+ E R + A +K +K + L+ A E+L + +A++ + +S+ +
Sbjct: 1463 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1522
Query: 284 WKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMED---------------------- 321
+ ++ K LE Q+E MK Q+ L ++L+ ED
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1582
Query: 322 ---HGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQ-EVEK 377
+ ++ R++H EYE E LE+ + + LAA + +E +L +L+ + +
Sbjct: 1583 RDEQNEEKRRQLQRQLH--EYETE---LEDERKQRALAAAAKK--KLEGDLKDLELQADS 1635
Query: 378 KQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELE 437
K E K Q++KLQ + + E+ ++I T +N EK +E+ L +L+
Sbjct: 1636 AIKGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFATAKEN-EKKAKSLEADLMQLQ 1693
Query: 438 RVCDSLTAAERRLHEC---------------------QESLQCCKGKCADQEHTIRELQG 476
+ L AAER + Q+ + + + A E + E QG
Sbjct: 1694 ---EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1750
Query: 477 QVDGNHNLLTKLSLEEENCLIQLKCE-NLQQKLE----QMDAENKELEKKLANQEECLKH 531
++ + + K + + E +L E + QK E Q++ +NKEL KL E +K
Sbjct: 1751 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1810
Query: 532 SNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNE 591
KFK A A QLE +E+ ++ + + ++ L+ +L +E E RK E
Sbjct: 1811 ---KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE-RKMAE 1866
Query: 592 EQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESI 628
+ + K N++ +K+++ LE++E +++ I
Sbjct: 1867 QYKEQAEKGNAR-------VKQLKRQLEEAEEESQRI 1896
Score = 80.5 bits (197), Expect = 4e-15
Identities = 135/661 (20%), Positives = 270/661 (40%), Gaps = 111/661 (16%)
Query: 47 KTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSALNLKISEQKEILIKELDTF 106
K L+ T +E E+ EL K+ +K E L + +++E+K +L ++L
Sbjct: 842 KPLLQVTRQEEEMQAKEDELQKT--KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 899
Query: 107 KSVKLALEHL-LRKRDYKQTGDNLSSMLLENLTDNESENTNLKKKVFEKEAHIQELSCLF 165
+ E + +R KQ + + + L + E L+ + + + +L
Sbjct: 900 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 959
Query: 166 QSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDK---------------------LK 204
+ E+A ++LQ++ EA+ K L+
Sbjct: 960 EEEEA--------------ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE 1005
Query: 205 EYVKSLETKIAK-----WNLQSRMNKNEAIV--------MKEASRQKTVALKKASKVYKQ 251
E + L T +A+ NL NK+E+++ +E SRQ+ L+K + +
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE---LEKLKRKLEG 1062
Query: 252 RLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIIN 311
F I L +QI + + +L++ A + + + +K +I ++ I +
Sbjct: 1063 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1122
Query: 312 LLEDLKKMEDHGKNSCEEILR----KVHSIEYENETLNLENTKLKTTLAALKDEVVSVEN 367
L EDL E +N E+ R ++ +++ E E L++T + L A +++ V+V
Sbjct: 1123 LQEDLDS-ERAARNKAEKQKRDLGEELEALKTELED-TLDSTATQQELRAKREQEVTVLK 1180
Query: 368 ELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVK--SRCENLLHKNNQITKTKN------ 419
+ + +E + + EM + Q ++E E ++ R + L KN Q + +N
Sbjct: 1181 KALD-EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Query: 420 --------KNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQC-----------C 460
+ VE + ++E+ ++EL+ C A L++ LQ
Sbjct: 1240 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1299
Query: 461 KGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQM-DAENKELE 519
+GK + L Q+ LL + + ++ N + K L+++ + D ++E+E
Sbjct: 1300 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN--VSTKLRQLEEERNSLQDQLDEEME 1357
Query: 520 KKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIE------------- 566
K N E + N++ + + A +E ALEEG+++ +EIE
Sbjct: 1358 AK-QNLERHISTLNIQLSDSKKKLQDFASTVE-ALEEGKKRFQKEIENLTQQYEEKAAAY 1415
Query: 567 -KMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQN 625
K+ ++ LQ ++ DL +L + Q QLV + K + + L E +N K ++
Sbjct: 1416 DKLEKTKNRLQQELDDLVVDL----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1471
Query: 626 E 626
+
Sbjct: 1472 D 1472
Score = 76.6 bits (187), Expect = 6e-14
Identities = 90/431 (20%), Positives = 185/431 (42%), Gaps = 61/431 (14%)
Query: 217 WNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSE 276
W L +++ + +E Q + +K +Q+ ++ +E+ SQ+ +++ L E
Sbjct: 835 WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE 894
Query: 277 TISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLED----LKKMEDHG-------KN 325
+ A ++ E E+ V++ K+++ +L + L++ ED G K
Sbjct: 895 QLQAET-------ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 947
Query: 326 SCEEILRKVHSIEYE---NETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTL 382
+++L +E E + L LE + + L+DE++ ++++ ++L K++K L
Sbjct: 948 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL---SKERKLL 1004
Query: 383 IEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDS 442
E L E E K +TK KNK+ E M ++E LK+ E+
Sbjct: 1005 EERISDLTTNLAEEEE-----------KAKNLTKLKNKH-ESMISELEVRLKKEEKSRQE 1052
Query: 443 LTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCE 502
L +R+L +G +D I +LQ Q+ L K E + L +L E
Sbjct: 1053 LEKLKRKL----------EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1102
Query: 503 -----NLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEG 557
N +K+ +++ +L++ L ++ + + ++ E AL +LE L+
Sbjct: 1103 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS- 1161
Query: 558 RQKVAEEIEKMSSRESALQIKILDLET--------ELRKKNEEQNQLVCKMNSKAQHQEV 609
+E+ +E + K LD ET E+R+K+ + + + + + + +
Sbjct: 1162 -TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220
Query: 610 CLKEVQNSLEK 620
L + + +LEK
Sbjct: 1221 NLDKNKQTLEK 1231
Score = 40.4 bits (93), Expect = 0.005
Identities = 40/188 (21%), Positives = 80/188 (42%), Gaps = 32/188 (17%)
Query: 460 CKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQ-------------- 505
C+G A + R+ Q LT + + + NC LK N Q
Sbjct: 797 CRGYLARKAFAKRQQQ---------LTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQV 847
Query: 506 -QKLEQMDAENKELEKKLANQEEC---LKHSNLKFKEKSAEYTALARQLEAALEEGRQKV 561
++ E+M A+ EL+K Q++ LK K + + E L QL+A E +
Sbjct: 848 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE-----L 902
Query: 562 AEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKS 621
E E+M R +A + ++ ++ E+ + EE+ ++ ++ + + +++ LE+
Sbjct: 903 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 622 ENQNESIK 629
E + ++
Sbjct: 963 EAARQKLQ 970
Score = 35.8 bits (81), Expect = 0.13
Identities = 30/139 (21%), Positives = 62/139 (44%), Gaps = 1/139 (0%)
Query: 498 QLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEG 557
Q K EN ++LEQ ++ E + L Q + + +E A ++LE L E
Sbjct: 868 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 927
Query: 558 RQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNS 617
++ EE E + A + K+ +L ++ EE+ K+ + E +K++++
Sbjct: 928 EARLEEE-EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDE 986
Query: 618 LEKSENQNESIKNYLQFLK 636
+ ++QN + + L+
Sbjct: 987 ILVMDDQNNKLSKERKLLE 1005
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 103 bits (257), Expect = 5e-22
Identities = 143/644 (22%), Positives = 282/644 (43%), Gaps = 81/644 (12%)
Query: 44 LNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSALNLKISEQKEILIKEL 103
+ E +E + T+ E EL+T E T+ +I E L+ + E+ + L KE
Sbjct: 1295 VKEVSETQETMNELELLT---EQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKER 1351
Query: 104 DTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESENTNLKKKVFEKEAHIQEL-- 161
D K++K ALE K D + + ++ + ++ N+K+K E + E+
Sbjct: 1352 DNLKTIKEALEV---KHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQ 1408
Query: 162 -----SCLFQSEKANTLKANRFSQS------VKVVHERLQIQIHKREAENDKLKEYVKSL 210
S L + E + R +S V + LQ ++E+D+LKE +K +
Sbjct: 1409 FKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEI 1468
Query: 211 ---------ETKIAKWNLQSRMNK-NEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAI 260
E K+A L+ + NE V + ++K + +L + I
Sbjct: 1469 VAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEI 1528
Query: 261 EKLTSQIR-DQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKM 319
+ Q Q +++ E ++ +K H + K IE+ ++ N L++ ++
Sbjct: 1529 YEKEEQFNIKQISEVQEKVNELKQFKEHRKA----KDSALQSIESKMLELTNRLQESQEE 1584
Query: 320 EDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQ 379
EE+ R +++ E + L ENTK + A E E + ++ V + Q
Sbjct: 1585 IQIMIKEKEEMKRVQEALQIERDQLK-ENTK---EIVAKMKESQEKEYQFLKMTAVNETQ 1640
Query: 380 KTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRG------------ 427
+ + E ++ L+E E K EN+ +N ++T+ ++N+E+MR
Sbjct: 1641 EKMCE-----IEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVE 1695
Query: 428 --------QMESHLKE-----LERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIREL 474
Q++ +L+E LE+ + L L E QE++ +G +++ + I +
Sbjct: 1696 ETLKVERDQLKENLRETITRDLEKQ-EELKIVHMHLKEHQETIDKLRGIVSEKTNEISNM 1754
Query: 475 QGQVDGNHNLLTK--LSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHS 532
Q ++ +++ L L ++EE + + + Q+ ++++ E KL+N ++ L++S
Sbjct: 1755 QKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENS 1814
Query: 533 NLKFKEKSAEYTALARQ---LEAALEEGRQKVAE------EIEKMSSRESALQIKILDLE 583
N K +EK E A Q L+ + E ++KV+E +I+ S S L+I+ L+L
Sbjct: 1815 NAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLA 1874
Query: 584 TELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNES 627
+L +N E+ + V K + E LK ++ L++S + ++
Sbjct: 1875 QKLH-ENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKA 1917
Score = 86.7 bits (213), Expect = 6e-17
Identities = 138/660 (20%), Positives = 270/660 (40%), Gaps = 91/660 (13%)
Query: 33 ESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFEN--ANLSALNL 90
+S L K+ ++ + EL++ E +T ++ +P KD + + E +L
Sbjct: 673 QSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVP--KDLLCNLELEGKITDLQKELN 730
Query: 91 KISEQKEILIKE---LDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESENTNL 147
K E+ E L +E L KS+ +E L ++ K E L SE L
Sbjct: 731 KEVEENEALREEVILLSELKSLPSEVERLRKEIQDKS----------EELHIITSEKDKL 780
Query: 148 KKKVFEKEAHIQELSCLFQSEK-------ANTLKANRFSQSVKVVHERLQIQIHKREAEN 200
+V KE+ +Q L K +N ++ Q+ K +H + + EN
Sbjct: 781 FSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN 840
Query: 201 DKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKA---SKVYKQRLDHFT 257
+++ + + +L + K++ K E + ++KT +++ + K++L++
Sbjct: 841 ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD 900
Query: 258 GAIEKLTSQIRDQEAKLSETISA-------SNAWKSHYEKIVIEKTELEVQIETM----- 305
++ + + KL +T+ + K E + IE+ +L+ I
Sbjct: 901 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI 960
Query: 306 --KKQIINLLEDLKKMEDH----GKNSCEEILRKVHSIEYENETLNLENTKL-----KTT 354
++Q+ N LE LK+ ++ EE+ R +H E ET + K+ K
Sbjct: 961 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD 1020
Query: 355 LAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQI 414
L A + ++ + + +E+ E ++K +LI+ K ++Q++ E+ K + + L +N ++
Sbjct: 1021 LEAKNTQTLTADVKDNEIIEQQRKIFSLIQE-KNELQQMLESVIAEKEQLKTDLKENIEM 1079
Query: 415 TKTKNKNVEKMRGQMESHLK--------------ELERVCDSLTAAERRLHECQESLQCC 460
T + + + +++ + EL R CD L E +L E + LQ
Sbjct: 1080 TIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEK 1139
Query: 461 KGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEK 520
+ + + + + E+Q +++ NL +L +E L ++ E L+ L Q EN E K
Sbjct: 1140 QQQLLNVQEEMSEMQKKINEIENLKNELK-NKELTLEHMETERLE--LAQKLNENYEEVK 1196
Query: 521 KLANQEECLKHSNLKFKEKSAEYTALARQLEAA--------------LEEGRQKVAEEIE 566
+ + + LK F+ + R++EA L+E Q+ +E+
Sbjct: 1197 SITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKE-HQETIDELR 1255
Query: 567 KMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNE 626
+ S ++A I DLE K EE L ++ L V+ E E NE
Sbjct: 1256 RSVSEKTAQIINTQDLEKSHTKLQEEIPVL--------HEEQELLPNVKEVSETQETMNE 1307
Score = 79.7 bits (195), Expect = 8e-15
Identities = 140/654 (21%), Positives = 280/654 (42%), Gaps = 85/654 (12%)
Query: 33 ESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSALNLKI 92
ES + L + + E++ +KE E + V+ L + +D ++ EN +K
Sbjct: 1568 ESKMLELTNRLQESQEEIQIMIKEKEEMKR-VQEALQIERDQLK----ENTKEIVAKMKE 1622
Query: 93 SEQKEILIKELDTFKSVK---LALEHLLRKRDYKQTGDNLSSMLLEN--LTDNESENTNL 147
S++KE ++ + +EHL K ++ NL ++ EN LT EN
Sbjct: 1623 SQEKEYQFLKMTAVNETQEKMCEIEHL--KEQFETQKLNLENIETENIRLTQILHENLEE 1680
Query: 148 KKKVFEKEAHIQELSCLFQSEKANTLKAN---RFSQSVKVVHERLQIQIHKREAEN--DK 202
+ V ++ ++ + + E+ + LK N ++ ++ E + +H +E + DK
Sbjct: 1681 MRSVTKERDDLRSVEETLKVER-DQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDK 1739
Query: 203 LKEYVKSLETKIAKWNLQSRM-NKNEAIVMKEASRQKTVALKKAS-KVYKQRLDHFTGAI 260
L+ V +I+ N+Q + + N+A+ ++ Q+ + + K ++ +D G +
Sbjct: 1740 LRGIVSEKTNEIS--NMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIV 1797
Query: 261 ----EKLTSQIRDQE---AKLSETISASNAWKSHYEKIVIEKTELEVQ-----IETMKKQ 308
+KL++ +D E AKL E I A + ++ I ++K E Q +E +KKQ
Sbjct: 1798 SEKTDKLSNMQKDLENSNAKLQEKIQELKA--NEHQLITLKKDVNETQKKVSEMEQLKKQ 1855
Query: 309 IINLLEDLKKMEDHGKNSCEEI---LRKVHSIEYENETLNLENTKLKTTLAALKDEVVSV 365
I + L K+E N +++ L ++ S+ E + L LK LK+ +
Sbjct: 1856 IKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQET 1915
Query: 366 ENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKM 425
+ E+Q+ K + L + +K V KL+ E + K QI+ + K+++K
Sbjct: 1916 KARDLEIQQELKTARMLSKEHKETVDKLR----------EKISEKTIQISDIQ-KDLDKS 1964
Query: 426 RGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLL 485
+ +++ ++EL++ E +L +E + K + E ++ + Q L
Sbjct: 1965 KDELQKKIQELQK-------KELQLLRVKEDVNMSHKKINEMEQLKKQFEAQ------NL 2011
Query: 486 TKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTA 545
+ S+ +N + K L + LE++ KE + +L +E LK +F E A
Sbjct: 2012 SMQSVRMDNFQLTKK---LHESLEEIRIVAKERD-ELRRIKESLKMERDQFIATLREMIA 2067
Query: 546 LARQ------LEAALEEGRQKVAEEIEKMSSRESALQIKILD----------LETELRKK 589
RQ + L +G+Q + E + + SR L + + L +L K+
Sbjct: 2068 RDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKE 2127
Query: 590 NEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLK--TSYVT 641
E Q +L ++ + + K ++ ++ + ++ LK SYVT
Sbjct: 2128 IEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVT 2181
Score = 74.3 bits (181), Expect = 3e-13
Identities = 148/693 (21%), Positives = 297/693 (42%), Gaps = 115/693 (16%)
Query: 21 ISEKEDLPRCTSESHLSCLKQDILNEKTELEA-TLKEAEL-VTHSVELLLPLFKDTIEKI 78
+ + E L E L +++ L+E LE T K+ E+ + H + L L K E
Sbjct: 511 VLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHA-EVY 569
Query: 79 NFENANLSALNLKISEQKEILIKELDTF------KSVKLALEHLLRK----RDYKQTGDN 128
N + N + +++ +KE IK+L + +++K+ L + L + KQT +
Sbjct: 570 NQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFD 629
Query: 129 LSSMLLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHER 188
++ L D + E+ L+ + E + ++EL+ ++ + + ++ K +
Sbjct: 630 AETVAL----DAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVD 685
Query: 189 LQIQIHKREAENDKL---------KEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKT 239
L+ ++ E KL K+ + +LE + +LQ +NK + EA R++
Sbjct: 686 LEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKE--VEENEALREEV 743
Query: 240 VALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELE 299
+ L + L +E+L +I+D+ +L + S +K+ E E
Sbjct: 744 ILLSE--------LKSLPSEVERLRKEIQDKSEEL-------HIITSEKDKLFSEVVHKE 788
Query: 300 VQIETMKKQIINLLEDLKKMEDHGKNSCEEIL----------RKVHSIEYENETLNLENT 349
+++ + ++I +DL + + K++ +E +K + ENE +N E
Sbjct: 789 SRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIV 848
Query: 350 KLK-------TTLAALKDEVVSVENELSEL---------------QEVEKKQKTL--IEM 385
L ++L ALK E+ EL E +++E + TL +E
Sbjct: 849 NLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVER 908
Query: 386 YKTQV-QKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVC---- 440
KT + +KLQ+ E VK+ L + K ++++ R Q++S + + +
Sbjct: 909 EKTLITEKLQQTLEEVKT-----LTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQ 963
Query: 441 DSLTAAERRLHECQESLQCCKGKCADQE-----------HTIRELQGQVDGNHNLLTKLS 489
+ L A L + QE++ K K +++ T E Q ++ G + K
Sbjct: 964 EQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVG---IDKKQD 1020
Query: 490 LEEENC---LIQLKCENL---QQKLEQMDAENKELEKKLAN---QEECLKHSNLKFKEKS 540
LE +N +K + Q+K+ + E EL++ L + ++E LK + E +
Sbjct: 1021 LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT 1080
Query: 541 AEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKM 600
E R L L++ ++ VA+E +E L + D E+ +K +E++Q +
Sbjct: 1081 IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELS-RTCDRLAEVEEKLKEKSQQL--- 1136
Query: 601 NSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQ 633
+ Q Q + ++E + ++K N+ E++KN L+
Sbjct: 1137 -QEKQQQLLNVQEEMSEMQKKINEIENLKNELK 1168
Score = 73.2 bits (178), Expect = 7e-13
Identities = 136/665 (20%), Positives = 268/665 (40%), Gaps = 124/665 (18%)
Query: 43 ILNEKT-ELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSALNLKISEQKEILIK 101
I++EKT E+ K+ E HS + L E++ + +L I + + I+ +
Sbjct: 1743 IVSEKTNEISNMQKDLE---HSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSE 1799
Query: 102 ELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESENTNLKKKVFEKEAHIQEL 161
+ D +++ LE+ K K ++ L NE + LKK V E + + E+
Sbjct: 1800 KTDKLSNMQKDLENSNAKLQEK----------IQELKANEHQLITLKKDVNETQKKVSEM 1849
Query: 162 SCLFQSEKANTLKANRFS----QSVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAKW 217
L + K +L ++ + +HE L+ ++ E D L+ ++L K+ +
Sbjct: 1850 EQLKKQIKDQSLTLSKLEIENLNLAQKLHENLE-EMKSVMKERDNLRRVEETL--KLERD 1906
Query: 218 NLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSET 277
L+ + + +A ++ KT + SK +K+ +D I + T QI D + L ++
Sbjct: 1907 QLKESLQETKARDLEIQQELKTARM--LSKEHKETVDKLREKISEKTIQISDIQKDLDKS 1964
Query: 278 ISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLL---EDLKKMEDHGKNSCEEILRKV 334
K EL+ +I+ ++K+ + LL ED+ M N E++ ++
Sbjct: 1965 -----------------KDELQKKIQELQKKELQLLRVKEDVN-MSHKKINEMEQLKKQF 2006
Query: 335 HSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQ 394
+ +++ ++N +L L +E+ V E EL+ +++ K + + ++++
Sbjct: 2007 EAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREM- 2065
Query: 395 EAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKE-LERVCDSLTAAERRLHEC 453
I + R +N+Q+ K ++ + HL E L C + +R E
Sbjct: 2066 ----IARDR------QNHQVKPEK-----RLLSDGQQHLTESLREKCSRIKELLKRYSEM 2110
Query: 454 QESLQCCKGKCADQEHTI---RELQGQVDGNHNL-------LTKLSLEEENCLIQLKCEN 503
+ +C D E I +EL +V N +L + KL + C ++
Sbjct: 2111 DDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEF--HR 2168
Query: 504 LQQKL------------EQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQL- 550
+ +KL EQ ++ NK E ++ E K +K + + +R+L
Sbjct: 2169 IMKKLKYVLSYVTKIKEEQHESINK-FEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELR 2227
Query: 551 EAALEEGRQKVAEEIEK-----------------MSSRESALQI---------KILDLET 584
+ L + EEI K +S+R+ Q I L+
Sbjct: 2228 DLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKN 2287
Query: 585 ELRKKNEE--------QNQLVCKMNSKAQHQE---VCLKEVQNSLEKSENQNESIKNYLQ 633
++K+N+ N+++ MN + +E KE + L+ + +NE + Q
Sbjct: 2288 GIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQ 2347
Query: 634 FLKTS 638
LKTS
Sbjct: 2348 TLKTS 2352
Score = 71.6 bits (174), Expect = 2e-12
Identities = 146/695 (21%), Positives = 285/695 (41%), Gaps = 166/695 (23%)
Query: 36 LSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTI----EKIN--------FENA 83
+S +++D+ K EL+ ++E + EL L K+ + +KIN FE
Sbjct: 1954 ISDIQKDLDKSKDELQKKIQELQ----KKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQ 2009
Query: 84 NLSALNLKIS------------EQKEILIKELDTFKSVKLAL------------EHLLRK 119
NLS ++++ E+ I+ KE D + +K +L E + R
Sbjct: 2010 NLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARD 2069
Query: 120 RDYKQTGDNLSSM------LLENLTDNESENTNLKKKVFEKEAHIQELSCL--------- 164
R Q + L E+L + S L K+ E + H + L+ L
Sbjct: 2070 RQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIE 2129
Query: 165 FQSEKANTLKAN--------RFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAK 216
FQ E + +KAN + + + ++R ++ H+ KLK YV S TKI +
Sbjct: 2130 FQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMK---KLK-YVLSYVTKIKE 2185
Query: 217 WNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSE 276
+S +NK E + E +QK + +K + H + + ++RD KL++
Sbjct: 2186 EQHES-INKFEMDFIDEVEKQKELLIK---------IQHLQQDCDVPSRELRD--LKLNQ 2233
Query: 277 TISASNAWKSHYEKIVIEKTELEV-QIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVH 335
+ H E+I+ + +E E I+T +Q+++ +++ + + N+ +I + +
Sbjct: 2234 NMDL------HIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKN 2287
Query: 336 SIEYENETLNLENTKLKTTLAALKDEVVSVENELS--------ELQEVEKKQKTLIEMYK 387
I+ EN+ + N + A+ +E E + +L+ +++K + L + Y+
Sbjct: 2288 GIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQ 2347
Query: 388 TQVQKLQEAAEI-----------VKSRC-----------ENLLHKNNQITKTKNKNVEKM 425
T L A++ V SR EN LH+ + K + KM
Sbjct: 2348 TLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKM 2407
Query: 426 RGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLL 485
+ KELE D + + ++HE + L+ K TI+ LQ +V L
Sbjct: 2408 Q-------KELEVTNDIIAKLQAKVHESNKCLEKTK-------ETIQVLQDKV-----AL 2448
Query: 486 TKLSLEEENCLIQLKCENLQQKLEQMDAEN----KELEKKLA-------NQEECLK--HS 532
+EE E+L+ KL ++D E KE EK+++ Q+E ++
Sbjct: 2449 GAKPYKEE-------IEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRE 2501
Query: 533 NLKFKEKSAEYTALARQLEAALEE------GRQKVAEEIEKMSSRESALQIKILDLETEL 586
NL+ +++ + + ++ + G + + +++ L+ + + LE E+
Sbjct: 2502 NLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQ-----NTKALILKSEHIRLEKEI 2556
Query: 587 RKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKS 621
K ++ QL+ + N + + EV+ E++
Sbjct: 2557 SKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERT 2591
Score = 43.9 bits (102), Expect = 5e-04
Identities = 78/381 (20%), Positives = 170/381 (44%), Gaps = 54/381 (14%)
Query: 25 EDLPRCTSESHLSCLK---QDILNEKTELEATLKEAELVTHSVELL---LPLFKDTIEKI 78
E++ + SES +K Q +L+ + E+ L+E +E L + D I ++
Sbjct: 2240 EEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQV 2299
Query: 79 N--FENANLSALN--LKISEQKEILIKELDT-FKSVKLALEHLLRKRDYKQTGDNLSSML 133
N F N ++ +N + E+ + KE + KS+K E L + +Y+ +L+S
Sbjct: 2300 NNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFK--NYQTLKTSLASGA 2357
Query: 134 LENLTDNESENTNLK--------KKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVV 185
N T +++N ++ +K+ E E + E +++ +K + + +
Sbjct: 2358 QVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDI 2417
Query: 186 HERLQIQIHKREAENDKLKEYVKSLETKIAKW---------NLQSRMNKNEAIVMKEASR 236
+LQ ++H+ +K KE ++ L+ K+A +L+ ++ K + MK A
Sbjct: 2418 IAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKE 2477
Query: 237 -QKTVALKKASKVYKQRLDHFTGAIEKLTSQI-RDQEAKLSETISASNAWKSHYEKI--- 291
+K ++ KA+ Y++ + I L + R Q+A+ + IS + + +
Sbjct: 2478 FEKEISATKATVEYQKEV------IRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCG 2531
Query: 292 ----VIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLE 347
+++ T+ + +K + I L +++ K+ K E+++++ + + N+ L+ E
Sbjct: 2532 GGSGIVQNTKALI----LKSEHIRLEKEISKL----KQQNEQLIKQKNELLSNNQHLSNE 2583
Query: 348 -NTKLKTTLAALKDEVVSVEN 367
T + TL + V+ EN
Sbjct: 2584 VKTWKERTLKREAHKQVTCEN 2604
Score = 43.5 bits (101), Expect = 6e-04
Identities = 73/315 (23%), Positives = 127/315 (40%), Gaps = 31/315 (9%)
Query: 326 SCEEILRKVHSIEYENETLNLENTKLKTTLAAL-KDEVVSVENELSELQEVE-KKQKTLI 383
S +E L K + E + LE L+T A+ KD++ + E LQ+V+ +K + L
Sbjct: 339 STDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLT 398
Query: 384 EMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSL 443
M T L E+ R + +I K KN N + + ++ +L
Sbjct: 399 RMLVTS-SSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINL 457
Query: 444 TAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCEN 503
L E ES+ ++ T+ E++ + LL + ++E E ++ +N
Sbjct: 458 ------LREIDESVCSESDVFSNTLDTLSEIEW--NPATKLLNQENIESELNSLRADYDN 509
Query: 504 LQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAE 563
L EQ+ E +E+E K LK K E+ AL R+ + ++ ++
Sbjct: 510 LVLDYEQLRTEKEEMELK------------LKEKNDLDEFEALERKTK---KDQEMQLIH 554
Query: 564 EIEKMSSRESALQIKILDLETELRKKNE---EQNQLVCKMNSKAQHQEVCLKEVQNSLEK 620
EI + + ++ DLE EL K E E+ + K+ Q+ L+ ++ L
Sbjct: 555 EISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQK--LENIKMDLSY 612
Query: 621 SENQNESIKNYLQFL 635
S E K Q L
Sbjct: 613 SLESIEDPKQMKQTL 627
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 103 bits (257), Expect = 5e-22
Identities = 135/654 (20%), Positives = 282/654 (43%), Gaps = 59/654 (9%)
Query: 31 TSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSALNL 90
T E + + ++ + T ++ TL+ + E LL K+TI+ + L++
Sbjct: 259 TKEENPESDGEPVVEDGTSVK-TLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKE 317
Query: 91 KISEQKEILIKELDTFKSVKLA--LEHLLRKRDYKQTGDNLSS-----------MLLENL 137
+ EQ + ++EL+ K + +A + + + RD K + L + E L
Sbjct: 318 ALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETL 377
Query: 138 TDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKRE 197
E E L+ ++ + +EL Q EK+ +++ + + + +
Sbjct: 378 EMKEEEIAQLRSRIKQMTTQGEELR--EQKEKSERAAFEELEKALSTAQKTEEARRKLKA 435
Query: 198 AENDKLKEYVK-SLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHF 256
++++K K S E +I+ SR+ + VMK++S ++ L+K + R +
Sbjct: 436 EMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKE-- 493
Query: 257 TGAIEKLTSQIRDQEAKLSETIS-ASNAWKSHYEKIVIEKTELE----VQIETMKKQIIN 311
++LT +++ +E + E + A +S Y KI EK + E ++E KK I+
Sbjct: 494 ----QELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILT 549
Query: 312 LLED-LKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDE-----VVSV 365
E+ L+ ++ + IL S+E + ++ L L A K++ V V
Sbjct: 550 ESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMV 609
Query: 366 ENELSELQEVEKKQ--------KTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKT 417
E +EL+ ++ +Q + L + Y+T+++KL+E E K E LL I +
Sbjct: 610 EKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEK---ETLLKDKEIIFQA 666
Query: 418 KNKNV-EKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQG 476
+ + EK +++ ELE + L+ + H+ +E L K + + +
Sbjct: 667 HIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMD 726
Query: 477 QVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKF 536
+ +H ++E IQ + L+ ++ Q++ KE +K L + +++
Sbjct: 727 EQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADI 786
Query: 537 KEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQL 596
K E + +L+ + + E+ + + + LQ K+LDLETE ++ ++
Sbjct: 787 KRSEGELQQASAKLD-VFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEV 845
Query: 597 VCKMNSKAQHQEVCLK------EVQNSLEKSENQNESIKNYLQFLKTSYVTMFE 644
+AQ ++VC + +VQ+ +++ E QN ++ ++ L Y + E
Sbjct: 846 ------EAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLE 893
Score = 94.4 bits (233), Expect = 3e-19
Identities = 139/666 (20%), Positives = 284/666 (42%), Gaps = 86/666 (12%)
Query: 44 LNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSALNLKISEQKEILIKEL 103
LN++ E + E +L E+ + +KI +N +I+ KE +K+
Sbjct: 1051 LNQQAEELQEIHEIQLQEKEQEVA-----ELKQKILLFGCEKEEMNKEITWLKEEGVKQD 1105
Query: 104 DTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESE-NTNLKKKVFEKEAHIQELS 162
T ++ E L +K + + + L +L E + N +LK+ F +E + EL
Sbjct: 1106 TTLNELQ---EQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQE-QLVELK 1161
Query: 163 CLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSR 222
L + +K K + + +K E Q E N L++ KSLE K L +
Sbjct: 1162 MLAEEDKR---KVSELTSKLKTTDEEFQSLKSSHEKSNKSLED--KSLEFKKLSEELAIQ 1216
Query: 223 MN----KNEAIVMKEASRQKTVALKKASKVYKQ--RLDHFTGAIEKL----TSQIRDQEA 272
++ K EA++ + + ++ K + + + H T +++ T + + EA
Sbjct: 1217 LDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEA 1276
Query: 273 KLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHG--------- 323
+L + N +++ + E E QI++MK I +L+ + + ++ G
Sbjct: 1277 QLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASE 1336
Query: 324 KNSC-----EEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKK 378
K SC +E+ ++++ E L + ++ + L D V ++N +S L E E
Sbjct: 1337 KESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSIS-LSEKEAA 1395
Query: 379 QKTLIEMYK-------TQVQKLQEAAEIVK----SRCENLLHKNNQITKTKNK------- 420
+L + Y QVQ L + + S E + +N+ ++ K K
Sbjct: 1396 ISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQ 1455
Query: 421 ---NVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQ 477
V++++ Q+E KE + + + L + + C KG+ D + + + +
Sbjct: 1456 HQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESN 1515
Query: 478 VDGNHNLLTKLSLEEENCLIQ--LKCENLQQKL----EQMDAENKELEKKLANQEECLKH 531
++ T +E E+ + Q ++ E+L + L +Q D E+KEL +KL + +E +
Sbjct: 1516 LETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEE 1575
Query: 532 SNLKFKEKSAEYTALARQ---LEAALEEGRQK-------VAEEIEKMSSRESALQIKILD 581
+ + KE + L Q ++A LE +++ V + E++ + E L+ +
Sbjct: 1576 KDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAA 1635
Query: 582 LETELRKKNEE-----QNQLVCKMNSKAQH----QEVCLKEVQNSLEKSENQNESIKNYL 632
EL++K E+ + QL+ +M K + E L E+ L++ E + ++ L
Sbjct: 1636 KLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKL 1695
Query: 633 QFLKTS 638
+ +++S
Sbjct: 1696 KSVESS 1701
Score = 91.7 bits (226), Expect = 2e-18
Identities = 136/673 (20%), Positives = 286/673 (42%), Gaps = 87/673 (12%)
Query: 24 KEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFENA 83
KE+L + CLK ++ ++K+++E E S + +D I + E
Sbjct: 1485 KEELDQ--QNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIE 1542
Query: 84 NLSALNLKISEQKEI----LIKELDTFKSVKLALEHLLRKRDYK-QTGDNLSSMLLENLT 138
+L+ + ++QK+I L+++L F+ + ++ +++ + K T +N + L
Sbjct: 1543 SLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELE 1602
Query: 139 DNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKA--NRFSQSVKVVHERLQIQIHKR 196
+ E ++ V KE ++ L +SE A L + Q + + ++L Q+ ++
Sbjct: 1603 TKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEK 1662
Query: 197 EAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKE------ASRQKTVALKKASK--- 247
E ++Y K E+ +++ N + + + E +++E +S+ +T+ + +++K
Sbjct: 1663 E------EQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVA 1716
Query: 248 -VYKQRLDHFTGAIEK--------LTSQIRDQEAKLS-------ETISASNAWKSHYEKI 291
+Q G ++K L + ++E L ET+S+ + Y++
Sbjct: 1717 AYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQER 1776
Query: 292 VIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENT-- 349
+I+ E + + I +L E+L++ + + K NLEN
Sbjct: 1777 LIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFD 1836
Query: 350 KLKTTLAALKDEVVSVENELSELQEVEKKQKTL----IEMYKTQVQKLQEAAEIVKSRCE 405
++ TL + +E ++ EL +QK + +E ++ +KLQ ++
Sbjct: 1837 DVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKP 1896
Query: 406 NLLHKNNQITKTKN--------KNVEKMRGQMESHLKELERVCDSLTAAERRLH------ 451
L + N K+K+ N+E +E L ER L RL
Sbjct: 1897 TELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRML 1956
Query: 452 --ECQESLQCCKGKC-ADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQ--- 505
E Q+ L+ K + ++E I++ Q ++ HN K + E N + K + L+
Sbjct: 1957 RKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTI 2016
Query: 506 ------------QKLEQMDAENKELEKKLANQEECLKHSNLKFKE----KSAEYTALARQ 549
+ LE E +L KK+A +++ LK + +++E + E TA R
Sbjct: 2017 KETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRD 2076
Query: 550 LEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEV 609
L+ LEE ++K +++E+ + + + I++L+T+L +K L+ K Q
Sbjct: 2077 LQTQLEELQKKYQQKLEQEENPGND-NVTIMELQTQLAQK----TTLISDSKLKEQEFRE 2131
Query: 610 CLKEVQNSLEKSE 622
+ +++ L+K E
Sbjct: 2132 QIHNLEDRLKKYE 2144
Score = 90.5 bits (223), Expect = 4e-18
Identities = 140/687 (20%), Positives = 294/687 (42%), Gaps = 106/687 (15%)
Query: 1 MEKAVNDGSHSEE--------LFCHLKTISEKEDLPRCTSESHLSCLKQ---DILNEKTE 49
+EKA++ +EE + +KTI + + R + + LS +KQ D++ + +E
Sbjct: 416 LEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSE 475
Query: 50 LEAT----LKEAELVTHSVELLLPLF---KDTIEKINFENANLSALNLKISEQKE----I 98
+ L E EL EL L ++ E++ + LKIS++KE +
Sbjct: 476 EQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESL 535
Query: 99 LIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESENTNLKKKVFEKEAHI 158
++EL+ K L E + RD +Q + + +LE ++L+K + E +
Sbjct: 536 ALEELELQKKAILT-ESENKLRDLQQEAETYRTRILEL-------ESSLEKSLQENKNQS 587
Query: 159 QELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAKWN 218
++L+ ++EK N+ ++ + V+ E+ + ++ + + D L + + L+ + K
Sbjct: 588 KDLAVHLEAEK------NKHNKEITVMVEKHKTELESLKHQQDAL--WTEKLQ--VLKQQ 637
Query: 219 LQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTG-AIEKLTSQIRDQEAKLSET 277
Q+ M K + ++ ++K LK +++ ++ +EKL + K +E
Sbjct: 638 YQTEMEK----LREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKL-------DVKQTEL 686
Query: 278 ISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSI 337
S S S +++ + +LE ++ +K Q + ++L+ D KN ++ +V SI
Sbjct: 687 ESLS----SELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQ---QVDSI 739
Query: 338 EYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAA 397
E+E ++ T ALKD++ +E L E + K+ + +E + +++ +
Sbjct: 740 IKEHEV------SIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGEL 793
Query: 398 EIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELER------------------V 439
+ ++ + + T + K E+ Q++ L +LE V
Sbjct: 794 QQASAKLD-VFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDV 852
Query: 440 CDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQV--DGN--HNLLTKLSLEEENC 495
C L A + ++ + + L+ + + ++ ++ DGN ++ +E+EN
Sbjct: 853 CTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENM 912
Query: 496 LIQLK------CENLQQKLEQMDAE----NKELEKKLANQEECLKHSNLKFKEKSA---- 541
++Q++ E L QKL + N+E E K NQE+ ++ K KE
Sbjct: 913 ILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKK 972
Query: 542 ----EYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLV 597
+ L ++LE E QK + KM A I D + L +EQ + +
Sbjct: 973 KLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESL 1032
Query: 598 CKMNSKAQHQEVCLKEVQNSLEKSENQ 624
+++ + + + + E + + + E Q
Sbjct: 1033 TEVHRRELNDVISIWEKKLNQQAEELQ 1059
Score = 73.2 bits (178), Expect = 7e-13
Identities = 106/438 (24%), Positives = 191/438 (43%), Gaps = 75/438 (17%)
Query: 243 KKASKVYKQRLDHFTGAIEKLTSQIR-DQEAK--LSETISASNAWKSHYEKIVIEKTELE 299
KK + Q D I +L +++ DQ+AK L E AS K Y + L+
Sbjct: 172 KKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISV------LQ 225
Query: 300 VQIETMKKQI------INLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKT 353
Q+ +K+++ +++L+ L ++E E+ K + E + E + + T +KT
Sbjct: 226 TQVSLLKQRLRNGPMNVDVLKPLPQLEPQA-----EVFTKEENPESDGEPVVEDGTSVKT 280
Query: 354 TLAALKDEVVSVENELSELQEV---EKKQKTLIEMYKTQVQ-----KLQEAAEIVKSR-- 403
L L+ V EN L +E K+Q TL+ K +Q +LQE +I
Sbjct: 281 -LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMA 339
Query: 404 -----------CENLLHKNNQ-----ITKTKNKNVEKMR------GQMESHLKELERVCD 441
+NL+ + Q I +TK + E + Q+ S +K++ +
Sbjct: 340 EKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGE 399
Query: 442 SLTAAERRLHECQ-ESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLK 500
L + + E L+ E R+L+ ++D + K S EE
Sbjct: 400 ELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERI------ 453
Query: 501 CENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQK 560
+LQQ+L ++ E ++ KK +++E+ K L KE + + L ++L+ E +++
Sbjct: 454 --SLQQELSRVKQEVVDVMKK-SSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQ 510
Query: 561 VAEEIEKMSS------RESALQIKILDLETELRKK---NEEQNQLVCKMNSKAQHQEVCL 611
+ +EK S +E Q + E EL+KK E +N+L + +A+ +
Sbjct: 511 MKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLR-DLQQEAETYRTRI 569
Query: 612 KEVQNSLEKS--ENQNES 627
E+++SLEKS EN+N+S
Sbjct: 570 LELESSLEKSLQENKNQS 587
Score = 60.8 bits (146), Expect = 4e-09
Identities = 135/633 (21%), Positives = 252/633 (39%), Gaps = 129/633 (20%)
Query: 18 LKTISEKEDLPRCTSESHLSCLKQDILNEKTE---LEATLKEAELVTHSVELLLPLFKDT 74
L + EKE+ + +ESHLS L + + E LE LK E + S L++P
Sbjct: 1656 LSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVE-SSQSETLIVP----- 1709
Query: 75 IEKINFENANLSALNLKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLL 134
SA N+ ++E E D+ V+ E + S+L
Sbjct: 1710 ----------RSAKNVAAYTEQE----EADSQGCVQKTYEEKI-------------SVLQ 1742
Query: 135 ENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIH 194
NLT+ E + ++ E + E+ C +Q E+ L+ Q HE + H
Sbjct: 1743 RNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQ-ERLIKLEHAEAKQ-----HEDQSMIGH 1796
Query: 195 KREAENDKLKEY----VKSLETKIAKWNLQSRMNKNEAI---------------VMKEAS 235
+E +K K+Y + +E + K N+Q++ N ++++
Sbjct: 1797 LQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKI 1856
Query: 236 RQKTVALKKASKVYKQRLDHFTGAIEKLTS-QIRDQEAKLSETISASNAWKSH------- 287
++ L + +V++ ++ T EKL + Q D K +E + + KS
Sbjct: 1857 KELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPK 1916
Query: 288 -YEKIVIEKTELEVQI-------ETMKKQIINLLEDLKKMEDHGKNSCEEILRKVH---- 335
+ + +LE ++ + + K+I+ L +DL+ + + EIL+K +
Sbjct: 1917 LLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQEL-EILKKEYDQER 1975
Query: 336 --SIEYENETLNLE-NTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQK 392
I+ E E L L+ N+ LK + ++ E EL + T+ K + K
Sbjct: 1976 EEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQEL---------EMTI----KETINK 2022
Query: 393 LQEA-AEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLH 451
QE AE+++S E + NQ+ K + + ++ + + + L+ + +TA R L
Sbjct: 2023 AQEVEAELLESHQE----ETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQ 2078
Query: 452 ECQESLQCCKGKCADQEH-------TIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENL 504
E LQ + +QE TI ELQ Q+ L++ L+E+ Q+ NL
Sbjct: 2079 TQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQI--HNL 2136
Query: 505 QQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEE 564
+ +L++ + + L H+++ + E+ L + L
Sbjct: 2137 EDRLKKYEKNVYATTVGTPYKGGNLYHTDVSLFGEPTEFEYLRKVL-------------- 2182
Query: 565 IEKMSSRESALQIKILDLETELRKKNEEQNQLV 597
E M RE+ K++ T + K ++Q Q +
Sbjct: 2183 FEYMMGRETKTMAKVI---TTVLKFPDDQTQKI 2212
Score = 30.0 bits (66), Expect = 6.9
Identities = 29/95 (30%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 9 SHSEELFCHLKTISEKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLL 68
SH EE LK I+EK+D + T++ + ++IL+ + E E T K +L T EL
Sbjct: 2033 SHQEETNQLLKKIAEKDDDLKRTAKRY-----EEILDAREE-EMTAKVRDLQTQLEELQK 2086
Query: 69 PLFKDTIEKINFENANLSALNLKIS-EQKEILIKE 102
+ ++ N N N++ + L+ QK LI +
Sbjct: 2087 KYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISD 2121
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 102 bits (254), Expect = 1e-21
Identities = 140/690 (20%), Positives = 280/690 (40%), Gaps = 97/690 (14%)
Query: 13 ELFCHLKTISEKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFK 72
E CH +E+ RC HL K+ + ELE L+E E ++L +
Sbjct: 914 EEICHDLEARVEEEEERC---QHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTE 970
Query: 73 DTIEKINFENANLSALNLKISEQKEILIKELDTF---------KSVKLA----------- 112
++K+ E L N K++++K++L + F KS LA
Sbjct: 971 AKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMIT 1030
Query: 113 -LEHLLRKRD----------YKQTGDNLSSMLLENLTDNESENTNLKKKVFEKEAHIQEL 161
LE LR+ + K GD S+ L + + + +++ LK ++ +KE +Q
Sbjct: 1031 DLEERLRREEKQRQELEKTRRKLEGD--STDLSDQIAELQAQIAELKMQLAKKEEELQAA 1088
Query: 162 SCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSL--ETKIAKWNL 219
+ E A A + + ++ LQ + A +K ++ + L E + K L
Sbjct: 1089 LARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTEL 1148
Query: 220 QSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETIS 279
+ ++ A + R++ V + K K ++ I+++ + +L+E +
Sbjct: 1149 EDTLDSTAAQQELRSKREQEVNILK--KTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE 1206
Query: 280 ASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEY 339
+ K++ EK K LE + + ++ LL+ GK E +KV +
Sbjct: 1207 QTKRVKANLEK---AKQTLENERGELANEVKVLLQ--------GKGDSEHKRKKVEAQLQ 1255
Query: 340 ENETLNLENTKLKTTLAALKDEVVSVENELSE----LQEVEKKQKTLIEMYKTQVQKLQE 395
E + E +++T LA D+V ++ EL L + + K L + + +LQ+
Sbjct: 1256 ELQVKFNEGERVRTELA---DKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQD 1312
Query: 396 AAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLH---- 451
E+++ ++ TK K VE + L+E E +L LH
Sbjct: 1313 TQELLQEE-----NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVA 1367
Query: 452 ECQESLQCCKGKCADQEHTIRELQGQVDG--------------NHNLLTKLSLEEENCLI 497
+ ++ ++ G E R+LQ ++G T+L E ++ L+
Sbjct: 1368 DMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLV 1427
Query: 498 QL--------KCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQ 549
L E Q+K +Q+ AE K + K A + + + + +EK + +LAR
Sbjct: 1428 DLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERD---RAEAEAREKETKALSLARA 1484
Query: 550 LEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEV 609
LE A+E+ E+E+++ + ++ + ++ K E + + + + +
Sbjct: 1485 LEEAMEQ-----KAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKT 1539
Query: 610 CLKEVQNSLEKSENQNESIKNYLQFLKTSY 639
L+E+++ L+ +E+ ++ LQ +K +
Sbjct: 1540 QLEELEDELQATEDAKLRLEVNLQAMKAQF 1569
Score = 91.3 bits (225), Expect = 3e-18
Identities = 139/679 (20%), Positives = 269/679 (39%), Gaps = 127/679 (18%)
Query: 40 KQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSALNLKISEQKEIL 99
K D +++ ++EA L+E ++ + E + D + K+ E N++ L + + L
Sbjct: 1240 KGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKL 1299
Query: 100 IKELDTFKSVKLALEHLLRKRD---------YKQTGDNLSSMLLENLTDNESENTNLKKK 150
K+ +S + LL++ + KQ D +S E L + E NL+K+
Sbjct: 1300 TKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFR-EQLEEEEEAKHNLEKQ 1358
Query: 151 VFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSL 210
+ A + ++ + A + ++ E L + ++ A DKL++
Sbjct: 1359 IATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEK----- 1413
Query: 211 ETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQ 270
K LQ ++ + +V + RQ L+K K + Q L K + RD+
Sbjct: 1414 ----TKTRLQQELD--DLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEE-RDR 1466
Query: 271 ---EAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSC 327
EA+ ET + S A + + E E + ++E + KQ +EDL +D S
Sbjct: 1467 AEAEAREKETKALSLA------RALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSV 1520
Query: 328 EEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSEL------------QEV 375
E+ + ++E + E + + +L+ L A +D + +E L + ++
Sbjct: 1521 HELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQS 1580
Query: 376 EKKQKTLIEMYKTQVQKLQEA------AEIVKSRCENLLHKNNQITKTKNKN-------V 422
E+K+K L+ + +L++ A + + E L + NKN +
Sbjct: 1581 EEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQL 1640
Query: 423 EKMRGQMESHLKELE----------------------------RVCDSLTAAERRLHECQ 454
K++ QM+ ++EL+ ++ + L AAER + Q
Sbjct: 1641 RKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQ 1700
Query: 455 ---------------------ESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEE 493
E + + + A E + E QG + ++ L K +L+ +
Sbjct: 1701 QERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQID 1760
Query: 494 NCLIQL--------KCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTA 545
L K EN +Q+LE+ +NKEL+ KL E +K K+K A
Sbjct: 1761 QINTDLNLERSHAQKNENARQQLER---QNKELKVKLQEMEGTVKS---KYKASITALEA 1814
Query: 546 LARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQ 605
QLE L+ ++ +++ E L+ +L ++ E R + ++Q A
Sbjct: 1815 KIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQ--------AD 1866
Query: 606 HQEVCLKEVQNSLEKSENQ 624
LK+++ LE++E +
Sbjct: 1867 KASTRLKQLKRQLEEAEEE 1885
Score = 88.6 bits (218), Expect = 2e-17
Identities = 132/594 (22%), Positives = 259/594 (43%), Gaps = 80/594 (13%)
Query: 90 LKISEQK---EILIKELDTFKSVKLALEHLLRKRDYKQT-----GDNLSSMLLENLTDNE 141
+K+ E++ E + E++T +S +A + L+++ +T + L + L + E
Sbjct: 855 VKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELE 914
Query: 142 SENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAEND 201
+L+ +V E+E Q L + + N + + + ++LQ++ EA+
Sbjct: 915 EICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLK 974
Query: 202 KLKEYVKSLE---TKIAKWN--LQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHF 256
KL+E LE K+AK L+ R+ + + +E + K++A K
Sbjct: 975 KLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLK------------ 1022
Query: 257 TGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDL 316
K + I D E +L + K+ + T+L QI ++ QI L L
Sbjct: 1023 ----NKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQL 1078
Query: 317 KKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVE 376
K E EE+ + +E E N+ K++ + + + +E+E + + E
Sbjct: 1079 AKKE-------EELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAE 1131
Query: 377 KKQKTL---IEMYKTQVQKLQE---AAEIVKSRCE---NLLHKN-NQITKTKNKNVEKMR 426
K+++ L +E KT+++ + A + ++S+ E N+L K + KT +++MR
Sbjct: 1132 KQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMR 1191
Query: 427 GQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLT 486
+ ++EL + + L + +++L+ +G+ A++ + LQG+ D H
Sbjct: 1192 QKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVL--LQGKGDSEHK--- 1246
Query: 487 KLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTAL 546
+ +E + +Q+K ++ ++ + +L+ +L N L S+ K + + +++AL
Sbjct: 1247 RKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSAL 1306
Query: 547 ARQL----EAALEEGRQKVA-------EEIEKMSSRESALQIKILDLETELRKKNEEQ-- 593
QL E EE RQK++ E EK S RE L+ E E + E+Q
Sbjct: 1307 ESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQ------LEEEEEAKHNLEKQIA 1360
Query: 594 --NQLVCKMNSKAQHQEVCL---KEVQNSLEK-----SENQNESIKNYLQFLKT 637
+ V M K + CL +EV+ L+K S+ E + Y + KT
Sbjct: 1361 TLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKT 1414
Score = 86.7 bits (213), Expect = 6e-17
Identities = 134/675 (19%), Positives = 277/675 (41%), Gaps = 121/675 (17%)
Query: 33 ESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLS---ALN 89
++ ++ LK + ++ EL+A L E + L ++ +I+ +L A
Sbjct: 1068 QAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASR 1127
Query: 90 LKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESENTNLKK 149
K +QK L +EL+ K+ + + T D+ ++ + L + N+ K
Sbjct: 1128 NKAEKQKRDLGEELEALKT------------ELEDTLDSTAAQ--QELRSKREQEVNILK 1173
Query: 150 KVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKS 209
K E+EA E +K SQ+V+ + E+L+ Q + +A +K K+ +++
Sbjct: 1174 KTLEEEAKTHEAQIQEMRQK--------HSQAVEELAEQLE-QTKRVKANLEKAKQTLEN 1224
Query: 210 LETKIA---------KWNLQSRMNKNEA------IVMKEASRQKTVALKKASKVYKQRLD 254
++A K + + + K EA + E R +T K +K+ + LD
Sbjct: 1225 ERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVE-LD 1283
Query: 255 HFTGAIEK--------------LTSQIRDQE--------------AKLSETISASNAWKS 286
+ TG + + L SQ++D + KL + N+++
Sbjct: 1284 NVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFRE 1343
Query: 287 HYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGK--NSCEEILRKVHS----IEYE 340
E+ K LE QI T+ Q+ ++ KKMED + EE+ RK+ +
Sbjct: 1344 QLEEEEEAKHNLEKQIATLHAQVADMK---KKMEDSVGCLETAEEVKRKLQKDLEGLSQR 1400
Query: 341 NETLNLENTKLKTTLAALKDEV----VSVENELSELQEVEKKQKT---LIEMYKTQVQKL 393
+E KL+ T L+ E+ V ++++ +EKKQK L+ KT K
Sbjct: 1401 HEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKY 1460
Query: 394 QEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLK----ELERVCDSLTAAERR 449
E + ++ K + + + +E+ + ++E K E+E + S +
Sbjct: 1461 AEERDRAEAEAREKETKALSLARALEEAMEQ-KAELERLNKQFRTEMEDLMSSKDDVGKS 1519
Query: 450 LHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLE 509
+HE ++S + + + + + + EL+ ++ + KL LE +Q ++ L+
Sbjct: 1520 VHELEKSKRALEQQVEEMKTQLEELEDELQATED--AKLRLEVN---LQAMKAQFERDLQ 1574
Query: 510 QMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMS 569
D +++E +K+L Q R++EA LE+ R++ + +
Sbjct: 1575 GRDEQSEEKKKQLVRQ---------------------VREMEAELEDERKQRSMAV---- 1609
Query: 570 SRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIK 629
+ L++ + DLE + N+ +++ + ++ + C++E+ ++ E K
Sbjct: 1610 AARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAK 1669
Query: 630 NYLQFLKTSYVTMFE 644
+ LK+ M +
Sbjct: 1670 ENEKKLKSMEAEMIQ 1684
Score = 79.0 bits (193), Expect = 1e-14
Identities = 94/441 (21%), Positives = 198/441 (44%), Gaps = 43/441 (9%)
Query: 213 KIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGA-----IEKLTSQI 267
K+ W K + ++ + SRQ+ + K ++ K R +E L SQ+
Sbjct: 821 KLRNWQWWRLFTKVKPLL--QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQL 878
Query: 268 RDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSC 327
++ +L E + A ++ E EL ++ K+++ + DL+ + + C
Sbjct: 879 MAEKLQLQEQLQAET-------ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERC 931
Query: 328 EEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYK 387
+ + + ++ + L + + ++ L+ E V+ E +L +L+E ++ ++E
Sbjct: 932 QHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEE----EQIILE--- 984
Query: 388 TQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAE 447
Q KL + ++++ R N + K+K++ K++ + E+ + +LE + L E
Sbjct: 985 DQNCKLAKEKKLLEDRIAEFT-TNLTEEEEKSKSLAKLKNKHEAMITDLE---ERLRREE 1040
Query: 448 RRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQ-- 505
++ E +++ + +G D I ELQ Q+ L K E + L +++ E Q
Sbjct: 1041 KQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKN 1100
Query: 506 ---QKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVA 562
+K+ +++++ EL++ L ++ + + ++ E AL +LE L+ A
Sbjct: 1101 MALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLD----STA 1156
Query: 563 EEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKA----QHQEVCLKEVQNSL 618
+ E S RE + I LE E K +E Q Q + + +S+A Q K V+ +L
Sbjct: 1157 AQQELRSKREQEVNILKKTLEEE-AKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANL 1215
Query: 619 EKS----ENQNESIKNYLQFL 635
EK+ EN+ + N ++ L
Sbjct: 1216 EKAKQTLENERGELANEVKVL 1236
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 102 bits (253), Expect = 1e-21
Identities = 144/670 (21%), Positives = 297/670 (44%), Gaps = 127/670 (18%)
Query: 2 EKAVNDGSHSEELF---CHLKTISEKEDLPRCTSESHLSCLKQDI----------LNEKT 48
+K +N+G++ E CH +K S H L++++ +KT
Sbjct: 148 KKKINNGTNPETTTSGGCHSPEDEQK------ASHQHQEALRRELEAQVHTIRILTCQKT 201
Query: 49 ELEATLKEAELVTHSVELLLPLFKDTIEKIN----FENANLSALNLKISEQKEILIKELD 104
EL+ L ++ H+V+ L +D I +++ F AL+ ++ QK K+ D
Sbjct: 202 ELQMALYYSQ---HAVKQLEGEARDLISRLHDSWKFAGELEQALSA-VATQK----KKAD 253
Query: 105 TFKSVKLALEHLLRKRDYKQTGDNLSSMLLEN-LTDNESENTNLKKKVFEKEAHIQELSC 163
+ +E L ++RD LS L N +TD E + EK A +QE
Sbjct: 254 RY------IEELTKERDA------LSLELYRNTITDEELK---------EKNAKLQEKLQ 292
Query: 164 LFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRM 223
L +SEK+ ++ N K+ +L + + +AE D L + ++S+ K LQ+++
Sbjct: 293 LVESEKSE-IQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK-----LQAQV 346
Query: 224 NKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNA 283
+NE + ++Q+ + + ++++ + I++ +IR+QE K+ E
Sbjct: 347 EENE--LWNRLNQQQEEKMWRQ----EEKIQEWEEKIQEQEEKIREQEEKIRE------- 393
Query: 284 WKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKM--EDHGKNSCEEILRKVHSIEYEN 341
EK+ ++ + + E M++Q + E +KM ++ EE +R++ +E
Sbjct: 394 ---QEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQ 450
Query: 342 ETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVK 401
E + + K E +++E EK+Q+ +M++ Q +K++E E ++
Sbjct: 451 EKIREQEEK---------------RQEEEKIREQEKRQEQEAKMWR-QEEKIREQEEKIR 494
Query: 402 S------RCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVC---DSLTAAERRLHE 452
R E +H+ +I + + + ++ + E ++E E + + + E ++ +
Sbjct: 495 EQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRK 554
Query: 453 CQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMD 512
+E + + K DQE IRE + +V K+ +EE K ++K+ + +
Sbjct: 555 QEEKMWRQEEKMHDQEEKIREQEEKVWRQEE---KIREQEE------KIREQEEKIREQE 605
Query: 513 AENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRE 572
+E E+K+ QEE + K +E+ + R+ E + E +K+ E+ EK+ +E
Sbjct: 606 EMTQEQEEKMGEQEEKMCEQEEKMQEQEEKM----RRQEEKIREQEKKIREQEEKIREQE 661
Query: 573 SALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSE----NQNESI 628
+Q E +K EQ + +C+ K Q QE ++ + + + E Q E +
Sbjct: 662 EMMQ--------EQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKM 713
Query: 629 KNYLQFLKTS 638
+ + + L+ +
Sbjct: 714 QEHQEHLEAA 723
Score = 81.6 bits (200), Expect = 2e-15
Identities = 113/516 (21%), Positives = 234/516 (45%), Gaps = 68/516 (13%)
Query: 58 ELVTHSVELLLPLFKDTI--EKINFENANLSA-LNLKISEQKEILIKELDTFKSVKLALE 114
EL L L L+++TI E++ +NA L L L SE+ EI + K +K LE
Sbjct: 258 ELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLN----VKELKRKLE 313
Query: 115 H---LLRKRDYKQTGDNLSSMLLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKAN 171
LL ++ + D+L L +S + L+ +V E E + L Q ++
Sbjct: 314 RAKLLLPQQQLQAEADHLGKEL-------QSVSAKLQAQVEENELWNR----LNQQQEE- 361
Query: 172 TLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAK-WNLQSRMNKNEAIV 230
K R + ++ E++Q Q K + +K++E + + + W + +M + E ++
Sbjct: 362 --KMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMM 419
Query: 231 MKEAS---RQKTVALKKASKVYKQRLDHFTGAIEKLTSQ---------IRDQEAKLSETI 278
++ RQ+ + +K K+ + L+ EK+ Q IR+QE + +
Sbjct: 420 WEKEEKMRRQEEMMWEKEEKI--RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQE- 476
Query: 279 SASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIE 338
+ W+ EKI ++ ++ Q E M +Q + E K E+ + EE+ R+ I
Sbjct: 477 --AKMWRQE-EKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIR 533
Query: 339 YENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAE 398
E E + + K+ ++ + + + ++ + E+K + E Q +K++E E
Sbjct: 534 -EQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEE 592
Query: 399 IVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQ 458
++ + E + + ++T+ + EKM G+ E E++C+ E ++ E +E ++
Sbjct: 593 KIREQ-EEKIREQEEMTQEQE---EKM-GEQE------EKMCEQ----EEKMQEQEEKMR 637
Query: 459 CCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKEL 518
+ K +QE IRE + ++ ++ + +EE Q ++K+ + + + +E
Sbjct: 638 RQEEKIREQEKKIREQEEKIREQEEMMQE---QEEKMWEQ------EEKMCEQEEKMQEQ 688
Query: 519 EKKLANQEECLKHSNLKFKEKSAEYTALARQLEAAL 554
E+K+ QEE + ++ +++ + LEAA+
Sbjct: 689 EEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 724
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 100 bits (249), Expect = 4e-21
Identities = 132/590 (22%), Positives = 258/590 (43%), Gaps = 74/590 (12%)
Query: 58 ELVTHSVELLLPLFKDTI--EKINFENANLSA-LNLKISEQKEIL--IKELDT-FKSVKL 111
EL L L L+++TI E++ +NA L L L SE+ EI +KEL + KL
Sbjct: 197 ELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKL 256
Query: 112 ALEHLLRKRDYKQTGDNLSSM---LLENLTDNE---SENTNLKKKVFEKEAHIQELSCLF 165
L + + G L S+ L + +NE N ++K++ +E IQE
Sbjct: 257 LLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKI 316
Query: 166 QSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNK 225
Q ++ K + ++ E+++ Q + +K++ + + W + +M +
Sbjct: 317 QEQEE---KIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMM------WEKEEKMRR 367
Query: 226 NEAIVMKEAS---RQKTVALKKASKVYKQRLDHFTGAIEKLTSQ---------IRDQEAK 273
E ++ ++ RQ+ + +K K+ + L+ EK+ Q IR+QE +
Sbjct: 368 QEEMMWEKEEKMRRQEEMMWEKEEKI--RELEEKMHEQEKIREQEEKRQEEEKIREQEKR 425
Query: 274 LSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRK 333
+ + W+ EKI ++ ++ Q + M +Q + E K E+ + EE+ R+
Sbjct: 426 QEQE---AKMWRQE-EKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQ 481
Query: 334 VHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKL 393
I +E E + + K+ ++ + V + +++E E+K + E Q +K+
Sbjct: 482 EEKI-HEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKI 540
Query: 394 QEAAEIVKSRCENLLHKNNQI-TKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHE 452
+E E+ + E +H+ +I + K + E + E ++E E + + E ++ E
Sbjct: 541 REQEEMWRE--EEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQE---EKVWRQEEKIRE 595
Query: 453 CQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMD 512
+E Q + K QE IRE + K+ +EE K ++K+ + +
Sbjct: 596 QEEKRQEQEEKMWKQEEKIREQE----------EKIQEQEE------KIREQEEKIREQE 639
Query: 513 AENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRE 572
+E E+K+ QEE + K +E+ + RQ E + E +K+ E+ EK+ +E
Sbjct: 640 EMTQEQEEKMGEQEEKMCEQEEKMQEQEE---TMWRQ-EEKIREQEKKIREQEEKIREQE 695
Query: 573 SALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSE 622
+Q E +K EQ + +C+ K Q QE ++ + + + E
Sbjct: 696 EMMQ--------EQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE 737
Score = 98.6 bits (244), Expect = 2e-20
Identities = 143/689 (20%), Positives = 302/689 (43%), Gaps = 114/689 (16%)
Query: 2 EKAVNDGSHSEELF---CHLKTISEKEDLPRCTSESHLSCLKQDI----------LNEKT 48
+K +N+G++ E CH +K S H L++++ +KT
Sbjct: 87 KKKINNGTNPETTTSGGCHSPEDEQK------ASHQHQEALRRELEAQVHTIRILTCQKT 140
Query: 49 ELEATLKEAELVTHSVELLLPLFKDTIEKIN----FENANLSALNLKISEQKEILIKELD 104
EL+ L ++ H+V+ L +D I +++ F AL+ ++ QK K+ D
Sbjct: 141 ELQMALYYSQ---HAVKQLEGEARDLISRLHDSWKFAGELEQALSA-VATQK----KKAD 192
Query: 105 TFKSVKLALEHLLRKRDYKQTGDNLSSMLLEN-LTDNESENTNLKKKVFEKEAHIQELSC 163
+ +E L ++RD LS L N +TD E + EK A +QE
Sbjct: 193 RY------IEELTKERDA------LSLELYRNTITDEELK---------EKNAKLQEKLQ 231
Query: 164 LFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRM 223
L +SEK+ ++ N K+ +L + + +AE D L + ++S+ K LQ+++
Sbjct: 232 LVESEKSE-IQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK-----LQAQV 285
Query: 224 NKNEAIV-MKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASN 282
+NE + + +K ++ + +++++ I + +IR+QE K+
Sbjct: 286 EENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRR--QEEM 343
Query: 283 AWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKM--EDHGKNSCEEILRKVHSIEYE 340
W+ EK+ ++ + + E M++Q + E +KM ++ EE +R++ +E
Sbjct: 344 MWEKE-EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHE 402
Query: 341 NETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIV 400
E + + K E +++E EK+Q+ +M++ Q +K++E E +
Sbjct: 403 QEKIREQEEK---------------RQEEEKIREQEKRQEQEAKMWR-QEEKIREQEEKI 446
Query: 401 KSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDS--LTAAERRLHECQESLQ 458
+ + + + + +I + + E+ R + E ++ E++ + + + ++HE +E ++
Sbjct: 447 REQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIR 506
Query: 459 CCKGKCADQEHTIRELQGQVDGNHNLLTKLSL----------------EEENCLIQLKCE 502
+ K QE IRE + ++ + + E+E + K +
Sbjct: 507 KQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQ 566
Query: 503 NLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKE---KSAEYTALARQLEAALEEGRQ 559
+ K+ + + + +E E+K+ QEE ++ K +E K + R+ E ++E +
Sbjct: 567 EQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEE 626
Query: 560 KVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCL----KEVQ 615
K+ E+ EK+ +E Q E +K EQ + +C+ K Q QE + ++++
Sbjct: 627 KIREQEEKIREQEEMTQ--------EQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIR 678
Query: 616 NSLEKSENQNESIKNYLQFLKTSYVTMFE 644
+K Q E I+ + ++ M+E
Sbjct: 679 EQEKKIREQEEKIREQEEMMQEQEEKMWE 707
Score = 57.4 bits (137), Expect = 4e-08
Identities = 65/342 (19%), Positives = 148/342 (43%), Gaps = 19/342 (5%)
Query: 91 KISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESENTNLKKK 150
KI EQ++ +E ++ + E + R+ ++ + E E E +++
Sbjct: 418 KIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEE 477
Query: 151 VFEKEAHIQELSCLF-QSEKANTLKANRFSQSVKV--VHERLQIQIHKREAENDKLKEYV 207
++ +E I E ++ Q EK + + Q KV E+++ Q K + +K+
Sbjct: 478 MWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQE 537
Query: 208 KSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQI 267
+ + + W + +M++ E I +E +++ + + + +++ + EK I
Sbjct: 538 EKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEK----I 593
Query: 268 RDQEAKLSETISASNAWK------SHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMED 321
R+QE K E WK EKI ++ ++ Q E +++Q E +KM +
Sbjct: 594 REQEEKRQE--QEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGE 651
Query: 322 HGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKT 381
+ CE+ ++ + ET+ + K++ ++++ + + +QE E+K
Sbjct: 652 QEEKMCEQ----EEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE 707
Query: 382 LIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVE 423
E Q +K+QE E ++ + E + + ++ + + K E
Sbjct: 708 QEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 43.1 bits (100), Expect = 8e-04
Identities = 66/325 (20%), Positives = 135/325 (41%), Gaps = 47/325 (14%)
Query: 10 HSEELFCHLKTISEKEDLPRCTSESHLSCLKQDILNEKTEL----EATLKEAELVTHSVE 65
H +E + E+E++ R + H +++I +K ++ E K+ E V E
Sbjct: 461 HEQEKIREEEKRQEQEEMWRQEEKIHE---QEEIWRQKEKMHEQEEKIRKQEEKVWRQEE 517
Query: 66 LLLPLFKDTIEKINFENANLSALNLKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQT 125
+ ++ EKI + + KI EQ+E+ +E + K+ E ++++ K
Sbjct: 518 KI----REQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDK-- 571
Query: 126 GDNLSSMLLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKV- 184
+ E + ++KV+ +E I+E Q EK + + Q K+
Sbjct: 572 -----------MWRQEEKIREQEEKVWRQEEKIRE-----QEEKRQEQEEKMWKQEEKIR 615
Query: 185 -VHERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALK 243
E++Q Q K + +K++E + + + K Q + M+E Q+ +
Sbjct: 616 EQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQE---QEETMWR 672
Query: 244 KASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHY------EKIVIEKTE 297
+ K+ +Q I + +IR+QE + E W+ EK+ ++ +
Sbjct: 673 QEEKIREQEKK-----IREQEEKIREQEEMMQE--QEEKMWEQEEKMCEQEEKMQEQEEK 725
Query: 298 LEVQIETMKKQIINLLEDLKKMEDH 322
+ Q E M +Q + L + +KM++H
Sbjct: 726 MRRQEEKMWEQEVRLRQQEEKMQEH 750
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 100 bits (249), Expect = 4e-21
Identities = 137/632 (21%), Positives = 259/632 (40%), Gaps = 155/632 (24%)
Query: 21 ISEKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINF 80
+ EK+ L C + L +D++ EK +LE T+ E + + E + + + E +N
Sbjct: 515 VQEKQSLQNCQN------LSKDLMKEKAQLEKTI---ETLRENSERQIKILEQENEHLN- 564
Query: 81 ENANLSALNLKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDN 140
+S+L + E +K+++ E+ + K+T LS +
Sbjct: 565 --QTVSSLRQRSQISAEARVKDIEK--------ENKILHESIKETSSKLSKI-------- 606
Query: 141 ESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAEN 200
E E +KK++ H +E + E+A E L+ ++H E EN
Sbjct: 607 EFEKRQIKKEL----EHYKE-----KGERA----------------EELENELHHLEKEN 641
Query: 201 DKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTG-- 258
+ L++ + +L+ K EA Q+ L++ ++ K+ LD F
Sbjct: 642 ELLQKKITNLKITCEKI---------------EALEQENSELERENRKLKKTLDSFKNLT 686
Query: 259 ----AIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLE 314
++EK SQ+ ++ +L + + ++ +E ELE + E +KK + L
Sbjct: 687 FQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA 746
Query: 315 DLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQE 374
KK E +E + L++EN +L+ TL ++ +E SELQ+
Sbjct: 747 SFKKTE---------------RLEVSYQGLDIENQRLQKTLENSNKKIQQLE---SELQD 788
Query: 375 VEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLK 434
+E + +TL QK E +I R E L + +NK++E+ Q+E K
Sbjct: 789 LEMENQTL--------QKNLEELKISSKRLEQL--------EKENKSLEQETSQLEKDKK 832
Query: 435 ELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEEN 494
+LE+ +RL + E K E ++ N L ++ + +E+
Sbjct: 833 QLEK-------ENKRLRQQAEI------KDTTLEENNVKIGNLEKENKTLSKEIGIYKES 879
Query: 495 CLIQLKCENLQQKLEQMDAENKELEKK-------LANQEECLKHSNLKFKEKSAEYTALA 547
C+ +L++++ ENKEL K+ L E L LK ++ + + L
Sbjct: 880 CV----------RLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLT 929
Query: 548 RQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQ 607
+LE + + +E SR L+ K LE+ L+K E + + + + ++
Sbjct: 930 HELEKIGLNKERLLHDEQSTDDSRYKLLESK---LESTLKKSLEIKEEKIAALEAR---- 982
Query: 608 EVCLKEVQNSLEKSENQNESIKNYLQFLKTSY 639
LE+S N N+ ++ L+ +K +Y
Sbjct: 983 ----------LEESTNYNQQLRQELKTVKKNY 1004
Score = 85.9 bits (211), Expect = 1e-16
Identities = 133/611 (21%), Positives = 245/611 (40%), Gaps = 69/611 (11%)
Query: 41 QDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEK---INFENANLSALNLKISEQKE 97
QD+ E L+ L+E ++ + +E L K ++ + + L N ++ +Q E
Sbjct: 787 QDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE 846
Query: 98 ILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESENTNLKKKVFEKEAH 157
I L+ +VK+ K K+ G S + L + E EN L K+
Sbjct: 847 IKDTTLEE-NNVKIGNLEKENKTLSKEIGIYKESCV--RLKELEKENKELVKRATIDIKT 903
Query: 158 IQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLK---EYVKSLETKI 214
+ L SEK T + N + K+ HE +I ++K +D+ K LE+K+
Sbjct: 904 LVTLREDLVSEKLKTQQMNNDLE--KLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKL 961
Query: 215 AKWNLQSRMNKNEAIVMKEAS-----------RQKTVALKKASKVYKQRLDH-------- 255
+S K E I EA RQ+ +KK + KQR D
Sbjct: 962 ESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSP 1021
Query: 256 ---------------FTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEV 300
T + K+ ++ + E + + A K+ +++ + L+
Sbjct: 1022 PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQA 1081
Query: 301 QIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKD 360
QI +++Q ++L E ++ ++ EN TLN ++T L A L
Sbjct: 1082 QILALQRQTVSLQEQNTTLQTQNAK-----------LQVENSTLNSQSTSLMNQNAQLLI 1130
Query: 361 EVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNK 420
+ S+ENE + + + K+L + +KL+ E S E+L+ K+ + K+ +K
Sbjct: 1131 QQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTL-KSAHK 1189
Query: 421 NVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDG 480
N+E +E +L + L E+ L QE + ++L G+ D
Sbjct: 1190 NLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDR 1249
Query: 481 NHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKS 540
++ ++L E E ++Q +NL+ L E LE + + +E + ++ K
Sbjct: 1250 LNHTYSQLLKETE--VLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDIT-STKL 1306
Query: 541 AEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKK---NEEQNQLV 597
L QL+ LEE + + ++I+ + + L LE + K + EQ Q +
Sbjct: 1307 NNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTL------LEQNMESKDLFHVEQRQYI 1360
Query: 598 CKMNSKAQHQE 608
K+N + +E
Sbjct: 1361 DKLNELRRQKE 1371
Score = 65.5 bits (158), Expect = 1e-10
Identities = 87/441 (19%), Positives = 191/441 (43%), Gaps = 68/441 (15%)
Query: 257 TGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDL 316
T + + L+ ++ D +AK+ E ++E++++ ++++ +NLL D
Sbjct: 243 TESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA 302
Query: 317 KKME----------------DHGKNSCEEILRKVHSIEYEN---ETLNLENTKLKTTLAA 357
+ D ++ ++H IE+ E L +N L T
Sbjct: 303 RSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTM 362
Query: 358 LKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKT 417
L+D++ +L E+EK+ L K ++ ++ ++ + + E L+ +N +
Sbjct: 363 LEDQLEGTRARSDKLHELEKENLQL----KAKLHDMEMERDMDRKKIEELMEENMTLEMA 418
Query: 418 KNKNVEKMRGQMESHLKELERVCDSLTAAERRL-HECQE--SLQCCKGKCADQE--HTIR 472
+ +++++ + L+++ R + A ++ L HE E S + K + +Q T+
Sbjct: 419 QKQSMDESL-HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVE 477
Query: 473 ELQGQVD---GNHNLLTKLSLEE----------ENCLIQLK-----CENLQQKLEQMDA- 513
EL+ VD GN + + K+ E EN ++Q K C+NL + L + A
Sbjct: 478 ELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQ 537
Query: 514 ---------ENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEE 564
EN E + K+ QE + + + ++ +A AR + +E+ + + E
Sbjct: 538 LEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKD--IEKENKILHES 595
Query: 565 IEKMSSRESALQIKILDLETEL---RKKNEEQNQLVCKMNSKAQHQEVCLKEVQN----- 616
I++ SS+ S ++ + ++ EL ++K E +L +++ + E+ K++ N
Sbjct: 596 IKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITC 655
Query: 617 -SLEKSENQNESIKNYLQFLK 636
+E E +N ++ + LK
Sbjct: 656 EKIEALEQENSELERENRKLK 676
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 100 bits (248), Expect = 5e-21
Identities = 135/632 (21%), Positives = 261/632 (41%), Gaps = 156/632 (24%)
Query: 21 ISEKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINF 80
+ EK+ L C + L +D++ EK +LE T+ E + + E + + + E +N
Sbjct: 515 VQEKQSLQNCQN------LSKDLMKEKAQLEKTI---ETLRENSERQIKILEQENEHLN- 564
Query: 81 ENANLSALNLKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDN 140
+S+L + E +K+++ E+ + K+T LS +
Sbjct: 565 --QTVSSLRQRSQISAEARVKDIEK--------ENKILHESIKETSSKLSKI-------- 606
Query: 141 ESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAEN 200
E E +KK++ H +E + E+A E L+ ++H E EN
Sbjct: 607 EFEKRQIKKEL----EHYKE-----KGERA----------------EELENELHHLEKEN 641
Query: 201 DKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTG-- 258
+ L++ + +L+ K EA Q+ L++ ++ K+ LD F
Sbjct: 642 ELLQKKITNLKITCEKI---------------EALEQENSELERENRKLKKTLDSFKNLT 686
Query: 259 ----AIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLE 314
++EK SQ+ ++ +L + + ++ +E ELE + E +KK + L
Sbjct: 687 FQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA 746
Query: 315 DLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQE 374
KK E +E + L++EN +L+ TL ++ +E SELQ+
Sbjct: 747 SFKKTE---------------RLEVSYQGLDIENQRLQKTLENSNKKIQQLE---SELQD 788
Query: 375 VEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLK 434
+E + +TL QK E +I R E L + +NK++E+ Q+E K
Sbjct: 789 LEMENQTL--------QKNLEELKISSKRLEQL--------EKENKSLEQETSQLEKDKK 832
Query: 435 ELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEEN 494
+LE+ +RL + E K E ++ N L ++ + +E+
Sbjct: 833 QLEK-------ENKRLRQQAEI------KDTTLEENNVKIGNLEKENKTLSKEIGIYKES 879
Query: 495 CLIQLKCENLQQKLEQMDAENKELEKK-------LANQEECLKHSNLKFKEKSAEYTALA 547
C+ +L++++ ENKEL K+ L E L LK ++ + + L
Sbjct: 880 CV----------RLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLT 929
Query: 548 RQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQ 607
+LE + ++++ + + R L+ K LE+ L+K E + + + + ++
Sbjct: 930 HELE-KIGLNKERLLHDEQSTDDRYKLLESK---LESTLKKSLEIKEEKIAALEAR---- 981
Query: 608 EVCLKEVQNSLEKSENQNESIKNYLQFLKTSY 639
LE+S N N+ ++ L+ +K +Y
Sbjct: 982 ----------LEESTNYNQQLRQELKTVKKNY 1003
Score = 87.0 bits (214), Expect = 5e-17
Identities = 133/610 (21%), Positives = 246/610 (40%), Gaps = 68/610 (11%)
Query: 41 QDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEK---INFENANLSALNLKISEQKE 97
QD+ E L+ L+E ++ + +E L K ++ + + L N ++ +Q E
Sbjct: 787 QDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE 846
Query: 98 ILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESENTNLKKKVFEKEAH 157
I L+ +VK+ K K+ G S + L + E EN L K+
Sbjct: 847 IKDTTLEE-NNVKIGNLEKENKTLSKEIGIYKESCV--RLKELEKENKELVKRATIDIKT 903
Query: 158 IQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLK--EYVKSLETKIA 215
+ L SEK T + N + K+ HE +I ++K +D+ + K LE+K+
Sbjct: 904 LVTLREDLVSEKLKTQQMNNDLE--KLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLE 961
Query: 216 KWNLQSRMNKNEAIVMKEAS-----------RQKTVALKKASKVYKQRLDH--------- 255
+S K E I EA RQ+ +KK + KQR D
Sbjct: 962 STLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPP 1021
Query: 256 --------------FTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQ 301
T + K+ ++ + E + + A K+ +++ + L+ Q
Sbjct: 1022 ISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQ 1081
Query: 302 IETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDE 361
I +++Q ++L E ++ ++ EN TLN ++T L A L +
Sbjct: 1082 ILALQRQTVSLQEQNTTLQTQNAK-----------LQVENSTLNSQSTSLMNQNAQLLIQ 1130
Query: 362 VVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKN 421
S+ENE + + + K+L + +KL+ E S E+L+ K+ + K+ +KN
Sbjct: 1131 QSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTL-KSAHKN 1189
Query: 422 VEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGN 481
+E +E +L + L E+ L QE + ++L G+ D
Sbjct: 1190 LEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRL 1249
Query: 482 HNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSA 541
++ ++L E E ++Q +NL+ L E LE + + +E + ++ K
Sbjct: 1250 NHTYSQLLKETE--VLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDIT-STKLN 1306
Query: 542 EYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKK---NEEQNQLVC 598
L QL+ LEE + + ++I+ + + L LE + K + EQ Q +
Sbjct: 1307 NQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTL------LEQNMESKDLFHVEQRQYID 1360
Query: 599 KMNSKAQHQE 608
K+N + +E
Sbjct: 1361 KLNELRRQKE 1370
Score = 65.5 bits (158), Expect = 1e-10
Identities = 87/441 (19%), Positives = 191/441 (43%), Gaps = 68/441 (15%)
Query: 257 TGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDL 316
T + + L+ ++ D +AK+ E ++E++++ ++++ +NLL D
Sbjct: 243 TESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA 302
Query: 317 KKME----------------DHGKNSCEEILRKVHSIEYEN---ETLNLENTKLKTTLAA 357
+ D ++ ++H IE+ E L +N L T
Sbjct: 303 RSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTM 362
Query: 358 LKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKT 417
L+D++ +L E+EK+ L K ++ ++ ++ + + E L+ +N +
Sbjct: 363 LEDQLEGTRARSDKLHELEKENLQL----KAKLHDMEMERDMDRKKIEELMEENMTLEMA 418
Query: 418 KNKNVEKMRGQMESHLKELERVCDSLTAAERRL-HECQE--SLQCCKGKCADQE--HTIR 472
+ +++++ + L+++ R + A ++ L HE E S + K + +Q T+
Sbjct: 419 QKQSMDESL-HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVE 477
Query: 473 ELQGQVD---GNHNLLTKLSLEE----------ENCLIQLK-----CENLQQKLEQMDA- 513
EL+ VD GN + + K+ E EN ++Q K C+NL + L + A
Sbjct: 478 ELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQ 537
Query: 514 ---------ENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEE 564
EN E + K+ QE + + + ++ +A AR + +E+ + + E
Sbjct: 538 LEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKD--IEKENKILHES 595
Query: 565 IEKMSSRESALQIKILDLETEL---RKKNEEQNQLVCKMNSKAQHQEVCLKEVQN----- 616
I++ SS+ S ++ + ++ EL ++K E +L +++ + E+ K++ N
Sbjct: 596 IKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITC 655
Query: 617 -SLEKSENQNESIKNYLQFLK 636
+E E +N ++ + LK
Sbjct: 656 EKIEALEQENSELERENRKLK 676
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 99.8 bits (247), Expect = 7e-21
Identities = 158/677 (23%), Positives = 289/677 (42%), Gaps = 107/677 (15%)
Query: 40 KQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSA----LNLKISEQ 95
K + + +LE +K+ S E + + E++N E + L L+ S+
Sbjct: 301 KVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKL 360
Query: 96 KEILIKELDTFKSVKLAL------EHLLRKRDYKQTGDNLSSMLLENLTDNESENTNLKK 149
+ +K+ DT + L E + R + +N L DN NLK
Sbjct: 361 QPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKL 420
Query: 150 K----VFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHER---LQIQIH----KREA 198
K V EKE + LS + + + LK N + +K R L ++H EA
Sbjct: 421 KMRIEVLEKEKSL--LSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEA 478
Query: 199 ENDKLKEYVKSLETKIAKWNLQSRMN----KNEAIVMKEASRQKTVA------LKKASKV 248
+ +L + + ET IA+ R N K+ ++ + S+Q+ LK+
Sbjct: 479 KEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLND 538
Query: 249 YKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQ 308
K+R+ +T ++ Q+ KL ++ A N +K+ + L Q+ ++
Sbjct: 539 EKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQES 598
Query: 309 IINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLE-NTKLKTTLAALKD-EVVSVE 366
+++ ++ ++++H + + EE+ R + + ++LN + N+ K TL ++ EV +++
Sbjct: 599 NVSIQKENLELKEHIRQNEEELSRIRNELM---QSLNQDSNSNFKDTLLKEREAEVRNLK 655
Query: 367 NELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMR 426
LSEL+++ + K + K + +KL A E V+ + E L NNQ++ KN VE ++
Sbjct: 656 QNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLK 715
Query: 427 GQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLT 486
ME E E L A++RL E + E TI EL + N +
Sbjct: 716 --MEKGEIEAE-----LCWAKKRLLE----------EANKYEKTIEELSNARNLN---TS 755
Query: 487 KLSLEEENCL-----IQLKCENLQQKLEQMDAENKE----LEKKLANQE----------- 526
L LE E+ + ++ L++ +EQMD ++KE L L Q+
Sbjct: 756 ALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEI 815
Query: 527 --ECLKHSNLKFKEKSAEYTALARQLE-------------AALEEGRQKVAEEIEKMSSR 571
E LK + K +E+ +Y+ R+ E +++E + EE+E++
Sbjct: 816 FIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREE 875
Query: 572 ES----ALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNES 627
+S K LD TEL + V ++N+ +H E +E+++ + E+QN+S
Sbjct: 876 QSRTAPVADPKTLDSVTELASE-------VSQLNTIKEHLE---EEIKHHQKIIEDQNQS 925
Query: 628 IKNYLQFLKTSYVTMFE 644
LQ L+ M E
Sbjct: 926 KMQLLQSLQEQKKEMDE 942
Score = 73.6 bits (179), Expect = 5e-13
Identities = 95/471 (20%), Positives = 208/471 (44%), Gaps = 71/471 (15%)
Query: 186 HERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKA 245
H++ +I +R E +L +Y + +E ++ Q E + K QKT+ + +
Sbjct: 243 HQQKLTEISRRHRE--ELSDYEERIE-ELENLLQQGGSGVIETDLSKIYEMQKTIQVLQI 299
Query: 246 SKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETM 305
KV T +E+L +I+D KLS + + + E++ +EK ++ + E +
Sbjct: 300 EKVES------TKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENL 353
Query: 306 KKQIINLLEDLKKMED---------HGKNSCEEILRKVHSI-EYENETLNLENTKLKTTL 355
K + L K D S EE+ R ++ + ENE + L + +L
Sbjct: 354 KLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSL 413
Query: 356 AALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQ----KLQEAAEIVKSRCENLLHKN 411
A +D + +L EV +K+K+L+ K ++Q KL E++KS + +
Sbjct: 414 A--EDNL-----KLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLD 466
Query: 412 NQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTI 471
+++ + N+E ++ + E E + + +R+ E + + K + + Q++
Sbjct: 467 SELHDLR-LNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNE- 524
Query: 472 RELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKH 531
++++KL + + ++++ Q++ + ++ K+L Q+E L
Sbjct: 525 ---------GDSIISKLKQD---------LNDEKKRVHQLEDDKMDITKELDVQKEKLIQ 566
Query: 532 SNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNE 591
S + + L +Q LE+ + + +++ K ++Q + L+L+ +R+ E
Sbjct: 567 SEVALND-----LHLTKQ---KLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEE 618
Query: 592 E----QNQLVCKMN--SKAQHQEVCLKE-------VQNSLEKSENQNESIK 629
E +N+L+ +N S + ++ LKE ++ +L + E NE++K
Sbjct: 619 ELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLK 669
Score = 73.2 bits (178), Expect = 7e-13
Identities = 144/673 (21%), Positives = 290/673 (43%), Gaps = 102/673 (15%)
Query: 11 SEELFCHLKTISEKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPL 70
++E H+ I ++ + +S +S LKQD+ +EK + + +T +++
Sbjct: 504 NQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQK-- 561
Query: 71 FKDTIEKINFENANLSALNL---KISEQKEILIKELDTFK--SVKLALEHLLRKRDYKQT 125
EK+ L+ L+L K+ ++ E L+ +L+ + +V + E+L K +Q
Sbjct: 562 -----EKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQN 616
Query: 126 GDNLSSMLLENLTD-NESENTNLKKKVF-EKEAHIQELSCLFQSEKANTLKANRFSQSVK 183
+ LS + E + N+ N+N K + E+EA ++ L + + + VK
Sbjct: 617 EEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVK 676
Query: 184 VVHERLQI-------QIHKREAENDKLK-------EYVKSLETKI------AKWNLQSRM 223
+ +E+L + Q+ + A N++L E +K + +I AK L
Sbjct: 677 MENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEA 736
Query: 224 NKNEAIV--MKEASRQKTVALKKASK---VYKQRLDHFTGAIEKLTSQIRDQEAKLSETI 278
NK E + + A T AL+ + Q+ D ++K Q+ + + +
Sbjct: 737 NKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVL 796
Query: 279 SASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIE 338
S+S + +++ +K E+ IE +K++ L E+L K + + EILR+ +IE
Sbjct: 797 SSSLEEQKQLTQLINKK---EIFIEKLKERSSKLQEELDKYSQALRKN--EILRQ--TIE 849
Query: 339 YENETLNL---ENTKLKTTLAALKDE---------------VVSVENELSEL-------- 372
++ +L EN L+ L L++E V + +E+S+L
Sbjct: 850 EKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLE 909
Query: 373 QEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESH 432
+E++ QK + + ++++Q LQ E K + +++ Q+ T + + +++S
Sbjct: 910 EEIKHHQKIIEDQNQSKMQLLQSLQE-QKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSL 968
Query: 433 LKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLE- 491
K +E++ + +LHE ++ +Q QE ++ L + + L+K E
Sbjct: 969 QKTIEQI-------KTQLHEERQDIQTDNSDIF-QETKVQSLNIENGSEKHDLSKAETER 1020
Query: 492 ------EENCLIQLKCENLQQKLEQMDAENKELEKKLAN--QEECLK----HSNLKFKEK 539
E I+L E +Q+D +K+ KL Q++ L+ H+ +
Sbjct: 1021 LVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSH 1080
Query: 540 SAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQI---KILDL----ETELRKKNEE 592
+ + L +QL+A E R+KV + + + S L+ K++D+ E L K +E
Sbjct: 1081 TQDVVYLQQQLQAYAME-REKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDE 1139
Query: 593 QNQLVCKMNSKAQ 605
+L + S Q
Sbjct: 1140 NKKLSTRFESSGQ 1152
Score = 67.4 bits (163), Expect = 4e-11
Identities = 91/493 (18%), Positives = 200/493 (40%), Gaps = 39/493 (7%)
Query: 91 KISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESENTNLKKK 150
++ K++L+ +LD S +L+ LL + + + S +L E+ + E L+K
Sbjct: 1297 QLCNTKDLLLGKLDII-SPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKS 1355
Query: 151 VFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSL 210
+ EK+A I+ L ++ + S+ + HE+ +I + + + D L++ +K
Sbjct: 1356 LQEKDATIRTLQ---ENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEK 1412
Query: 211 ETKIAKWN---LQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQI 267
+ I + L S N + E RQ LK+ + + + G EK+
Sbjct: 1413 DLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETY 1472
Query: 268 RDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSC 327
R +E + + + +N K + E E + +MK++ + + LK+ E
Sbjct: 1473 RGKETEY-QALQETNM------KFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGEL 1525
Query: 328 EEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYK 387
++L V S++ + E ++ L + E +++NE+ L++ E + +E +
Sbjct: 1526 NQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLR 1585
Query: 388 TQVQKLQEA----AEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSL 443
+ + +++ A + R L K + + + M ++E + + L
Sbjct: 1586 NHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQL 1645
Query: 444 TAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCEN 503
++ E L + + ++ LQ ++ + +EE + + E
Sbjct: 1646 NVVSKQRDETALQLSVSQEQVKQYALSLANLQ--------MVLEHFQQEEKAMYSAELEK 1697
Query: 504 LQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALE-------- 555
+Q + + + LE K+ + +ECL +N S L QL+ E
Sbjct: 1698 QKQLIAEWKKNAENLEGKVISLQECLDEANAALDSAS----RLTEQLDVKEEQIEELKRQ 1753
Query: 556 -EGRQKVAEEIEK 567
E RQ++ ++++K
Sbjct: 1754 NELRQEMLDDVQK 1766
Score = 60.1 bits (144), Expect = 6e-09
Identities = 126/657 (19%), Positives = 276/657 (42%), Gaps = 75/657 (11%)
Query: 29 RCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSAL 88
R +S SH QD++ + +L+A E E V L + T E + + +
Sbjct: 1074 RISSTSHT----QDVVYLQQQLQAYAMEREKV------FAVLNEKTRENSHLKTEYHKMM 1123
Query: 89 NLKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESENTNLK 148
++ ++ ++ LIK D K + E + +++T NLS ++ E + E L
Sbjct: 1124 DI-VAAKEAALIKLQDENKKLSTRFESSGQDM-FRETIQNLSRIIREK----DIEIDALS 1177
Query: 149 KKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVK 208
+K A +Q S +A + +N+F + ++ ++L+ Q+ K E ++ V+
Sbjct: 1178 QKCQTLLAVLQTSST---GNEAGGVNSNQFEELLQE-RDKLKQQVKKMEEWKQQVMTTVQ 1233
Query: 209 SLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKV--YKQ---RLDHF---TGAI 260
+++ + A+ LQ +++ +A V+ ++ + + + Y+Q +L +F +
Sbjct: 1234 NMQHESAQ--LQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQV 1291
Query: 261 EKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKME 320
+ Q+ + + L + + S + + E + K ++++ +L + E
Sbjct: 1292 QHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAEC---LRASKSEVLSESSELLQQE 1348
Query: 321 DHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKD-EVVSVENELSELQEVEKKQ 379
EE+ + + + TL N +L ++AA + E E SE++++++KQ
Sbjct: 1349 ------LEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQ 1402
Query: 380 KTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQ-------ITKTKNK------NVEKMR 426
L ++ K + ++ ++ + S EN +K N+ +T K + ++ K++
Sbjct: 1403 DVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLK 1462
Query: 427 GQMESHLK-------ELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVD 479
G+ E ++ E + + ++ L E + K K E ++E +
Sbjct: 1463 GENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKT 1522
Query: 480 GNHNLLTKL--SLEEENCLIQLKCENLQQKLEQMDAENKELEKKL---------ANQE-E 527
G N L S++E+ + Q + + + L+Q EN L+ ++ +NQE E
Sbjct: 1523 GELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELE 1582
Query: 528 CLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELR 587
L++ L+ ++ A EA L R+KV EK+ S +A++ ++
Sbjct: 1583 RLRNHLLESEDSYTREALAAEDREAKL---RKKVTVLEEKLVSSSNAMENASHQASVQVE 1639
Query: 588 KKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSYVTMFE 644
E+ N + + + A V ++V+ N ++++ Q K Y E
Sbjct: 1640 SLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELE 1696
Score = 32.0 bits (71), Expect = 1.8
Identities = 27/116 (23%), Positives = 56/116 (48%), Gaps = 12/116 (10%)
Query: 470 TIRELQGQVDG-NHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEEC 528
++ L GQ+ ++L + + E E L + + ++ + +EN+ L+K + EE
Sbjct: 22 SLASLTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEK 81
Query: 529 LKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLET 584
+ S ++ K++S Y +Q E EI + +R+ ALQ ++L L++
Sbjct: 82 HEASEIQIKQQSTSYRNQLQQKEV-----------EISHLKARQIALQDQLLKLQS 126
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 99.0 bits (245), Expect = 1e-20
Identities = 133/645 (20%), Positives = 283/645 (43%), Gaps = 76/645 (11%)
Query: 33 ESHLSCLKQDILNEK---TELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSA-- 87
E LS + + NEK +L+ T+KE + ++ L + T K+ E A+L+
Sbjct: 1096 ELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDL 1155
Query: 88 --LNLKISEQKEILIKELDTFKSVKLALEHLLRKRD-----YKQTGDNLSSMLLENLTDN 140
LN ++ E + +L+ K + + L R + ++ T +L ++L +
Sbjct: 1156 ADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAEL 1215
Query: 141 ESENTNLK--KKVFEKEAHIQELSC---LFQSEKANTLKANRFSQSVKVVHERLQIQIHK 195
E + NL+ K+ EK+ +L L + E+ KAN ++ + ++E ++H+
Sbjct: 1216 EGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKAN--AEKLCTLYEE---RLHE 1270
Query: 196 REAENDKLKEYVKSLETKIAKWNLQS-----RMNKNEAIVMKEASRQKTVALKKASKVYK 250
A+ DK+ + L + K +S R+ + EA++ + SR+K+ ++ +
Sbjct: 1271 ATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALI-NQLSREKSNFTRQIEDLRG 1329
Query: 251 Q---------RLDHFTGAIEKLTSQIRDQ-------EAKLSETISASNA----WKSHYEK 290
Q L H ++ +R+Q +A+L T+S NA W+ YE
Sbjct: 1330 QLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYEN 1389
Query: 291 IVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTK 350
VI++TE +E KK++ L++ + + R H ++ E + K
Sbjct: 1390 NVIQRTE---DLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGK 1446
Query: 351 LKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHK 410
+++ A L + + L++ ++ ++ + L++ + +VQ L +K+ E +
Sbjct: 1447 VRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESI-V 1505
Query: 411 NNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHT 470
+ + +NKN+++ E+ + + + + L E ++ + + + + + T
Sbjct: 1506 GQETLRRENKNLQE----------EISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVT 1555
Query: 471 IRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLK 530
+ E +G ++ N + + LE L++ K E L++KL + D E + +K + L+
Sbjct: 1556 LEETEGALERNESKILHFQLE----LLEAKAE-LERKLSEKDEEIENFRRKQQCTIDSLQ 1610
Query: 531 HSNLKFKEKSAEYTALARQLEAALEEGRQKVA---EEIEKMSSRESALQIKILDLE---- 583
S + E T L +++E L E +++ ++ + + LQI+I DL+
Sbjct: 1611 SSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLD 1670
Query: 584 --TELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNE 626
T+L +EQ + + NS Q + L+ +Q E+ +E
Sbjct: 1671 DSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSE 1715
Score = 80.9 bits (198), Expect = 3e-15
Identities = 111/624 (17%), Positives = 260/624 (41%), Gaps = 75/624 (12%)
Query: 12 EELFCHLKTISEKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLF 71
+E F K I + E + SE + + N E+E ++ + + +++
Sbjct: 957 DECFELKKEIDDLETM-LVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAH 1015
Query: 72 KDTIEKINFENANLSAL---NLKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDN 128
+ T++ ++ E LS+L NLK+ +Q + L L+ + ++ E L K +
Sbjct: 1016 QQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNL---K 1072
Query: 129 LSSMLLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHER 188
L+ +ENL ES +L +++ +KE + +++ ++EK + + + ++ +
Sbjct: 1073 LNRESMENL---ESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKD 1129
Query: 189 LQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKV 248
L+ ++ K++ L +A N + ++ E ++++ +K +
Sbjct: 1130 LKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRD 1189
Query: 249 YKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQ 308
++ HF L + D A+L + K EK +K++L+++++
Sbjct: 1190 MEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEK---DKSDLQLEVD----D 1242
Query: 309 IINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENE 368
++ +E + + + + + C ++H + + + T+L LAA K ++ S E
Sbjct: 1243 LLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKV----TQLANDLAAQKTKLWSESGE 1298
Query: 369 LSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKN---KNVEKM 425
L+ +E+K+ + NQ+++ K+ + +E +
Sbjct: 1299 F--LRRLEEKEALI-----------------------------NQLSREKSNFTRQIEDL 1327
Query: 426 RGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLL 485
RGQ+E K + +L A+R +E + +++ EL H L
Sbjct: 1328 RGQLEKETKSQSALAHALQKAQRDCDLLREQYE-------EEQEVKAEL-------HRTL 1373
Query: 486 TKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTA 545
+K++ E ++ + N+ Q+ E ++ KEL +L E + +N ++A
Sbjct: 1374 SKVNAEMVQWRMKYE-NNVIQRTEDLEDAKKELAIRLQEAAEAMGVAN----ARNASLER 1428
Query: 546 LARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQ 605
QL+ L + + ++ ++R Q++ + ++K+EE L+ + Q
Sbjct: 1429 ARHQLQLELGDALSDLG-KVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQ 1487
Query: 606 HQEVCLKEVQNSLEKSENQNESIK 629
L +++N+ E+S E+++
Sbjct: 1488 ALSTELLKLKNTYEESIVGQETLR 1511
Score = 74.3 bits (181), Expect = 3e-13
Identities = 108/563 (19%), Positives = 230/563 (40%), Gaps = 95/563 (16%)
Query: 75 IEKINFENANLSALNLKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLL 134
+EK F+ L A + ++++K LI +L +
Sbjct: 875 LEKSEFQREELKAKQVSLTQEKNDLILQLQAEQ--------------------------- 907
Query: 135 ENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIH 194
E L + E + L K + EA ++ELS + E+ ++ L +
Sbjct: 908 ETLANVEEQCEWLIKSKIQLEARVKELSERVEEEEE--------------INSELTARGR 953
Query: 195 KREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASR---QKTVALKKASKVYKQ 251
K E E +LK+ + LET + K + R +++ + E + L +A+KV ++
Sbjct: 954 KLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQE 1013
Query: 252 RLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIIN 311
A ++ + +E KLS ++S +N K+ + ELE +E +K +N
Sbjct: 1014 -------AHQQTLDDLHMEEEKLS-SLSKANL------KLEQQVDELEGALEQERKARMN 1059
Query: 312 LLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSE 371
+L K+E + K + E + ++E L E K + L+ + +V + + +++
Sbjct: 1060 CERELHKLEGNLKLNRESM----ENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQ 1115
Query: 372 LQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMES 431
LQ+ K+ +T I+ K ++ EA +++ E Q N+ +E++ G +
Sbjct: 1116 LQKTVKELQTQIKDLKEKL----EAERTTRAKMERERADLTQDLADLNERLEEVGGSSLA 1171
Query: 432 HLKELERVCDSLTAAERRLHECQESLQCCKGKCADQE-HTIRELQGQVDGNHNLLTKLSL 490
L+ ++ R + E + + ++ EL+GQV+ + K L
Sbjct: 1172 QLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQV--KQKL 1229
Query: 491 EEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQL 550
E++ +QL+ ++L ++EQM EK EE L + K
Sbjct: 1230 EKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKL-------------- 1275
Query: 551 EAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVC 610
+++ ++++ +A + K+ E ++ EE+ L+ +++ + +
Sbjct: 1276 ------------DKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQ 1323
Query: 611 LKEVQNSLEKSENQNESIKNYLQ 633
+++++ LEK ++ + LQ
Sbjct: 1324 IEDLRGQLEKETKSQSALAHALQ 1346
Score = 72.8 bits (177), Expect = 9e-13
Identities = 87/437 (19%), Positives = 181/437 (41%), Gaps = 53/437 (12%)
Query: 188 RLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASK 247
+LQ + K E + ++LK SL + KN+ I+ +A ++ +++ +
Sbjct: 870 QLQKALEKSEFQREELKAKQVSLTQE-----------KNDLILQLQAEQETLANVEEQCE 918
Query: 248 VYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKK 307
+ +++L+ ++ ++E SE + K+ E EL+ +I+ ++
Sbjct: 919 WLIKSKIQLEARVKELSERVEEEEEINSELTARGR-------KLEDECFELKKEIDDLET 971
Query: 308 QIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALK---DEVVS 364
++ ++ + E KN EE+ E+ NE ++ N K A + D++
Sbjct: 972 MLVKSEKEKRTTEHKVKNLTEEV-------EFLNEDISKLNRAAKVVQEAHQQTLDDLHM 1024
Query: 365 VENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEK 424
E +LS L + K +E +++ E + CE LHK K +++E
Sbjct: 1025 EEEKLSSLSKANLK----LEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMEN 1080
Query: 425 MRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNL 484
+ + HL E L E L + ++ KG A + T++ELQ Q+
Sbjct: 1081 LESS-QRHLAE------ELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEK 1133
Query: 485 L-----TKLSLEEENCLIQLKCENLQQKLEQMDAEN-------KELEKKLANQEECLKHS 532
L T+ +E E + +L ++LE++ + K+ E K ++ +
Sbjct: 1134 LEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEA 1193
Query: 533 NLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRK--KN 590
L F+ SA A LE + + + +K+ +S LQ+++ DL T + + +
Sbjct: 1194 TLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRA 1253
Query: 591 EEQNQLVCKMNSKAQHQ 607
+ + +C + + H+
Sbjct: 1254 KANAEKLCTLYEERLHE 1270
Score = 54.7 bits (130), Expect = 3e-07
Identities = 165/826 (19%), Positives = 303/826 (36%), Gaps = 221/826 (26%)
Query: 12 EELFCHLKTISEKEDLPRCTS---ESHLSCLKQDI--LNEKTE---------LEATLKEA 57
+EL +K + EK + R T E + L QD+ LNE+ E LE T K+
Sbjct: 1121 KELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQE 1180
Query: 58 -----------ELVTHSVELLLPLFK---DTIEKINFENANLSALNLKISEQKEILIKEL 103
E H L K D++ ++ + NL + K+ + K L E+
Sbjct: 1181 TKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEV 1240
Query: 104 DTF----------KSVKLALEHLLRKRDYKQTGD-----NLSSMLLENLTDNESENTNLK 148
D K+ L L +R ++ T L++ L T SE+
Sbjct: 1241 DDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFL 1300
Query: 149 KKVFEKEAHIQELSCLFQSEKAN----------TLKANRFSQSVKVVH---------ERL 189
+++ EKEA I +LS EK+N L+ SQS + H + L
Sbjct: 1301 RRLEEKEALINQLS----REKSNFTRQIEDLRGQLEKETKSQSA-LAHALQKAQRDCDLL 1355
Query: 190 QIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMN------------KNEAIVMKEASRQ 237
+ Q + + +L + + ++ +W ++ N K AI ++EA+
Sbjct: 1356 REQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEA 1415
Query: 238 KTVA------LKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEK- 290
VA L++A + L + K+ S + K ++ A WK +E+
Sbjct: 1416 MGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEES 1475
Query: 291 -IVIEKTELEVQI-------------------ETMKKQIINLLEDLKKMEDHGKNSCEEI 330
+++ ++ EVQ ET++++ NL E++ + N E
Sbjct: 1476 QALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLT----NQVREG 1531
Query: 331 LRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQ--------EVEKKQKTL 382
+ + +E + + E T+++ TL + + E+++ Q E+E+K
Sbjct: 1532 TKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEK 1591
Query: 383 IEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVE------------------- 423
E + +K Q + ++S ++ ++T+ K K E
Sbjct: 1592 DEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEA 1651
Query: 424 -KMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDG-- 480
K GQ++ +K+L+ D T L E + + +R LQ Q +
Sbjct: 1652 TKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGR 1711
Query: 481 --------------------NHNLLT-KLSLEEENCLIQLKCE----------------- 502
N +LL+ K LE + +Q + E
Sbjct: 1712 RLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAA 1771
Query: 503 ----NLQQKL--------------EQMDAENKELEKKLANQEECLKHSNLKFKEK----- 539
NL ++L E M+ +L+K+LA E+ + K +K
Sbjct: 1772 IEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRV 1831
Query: 540 -------------SAEYTALARQLEAALEEGRQKVAEE---IEKMSSRESALQIKILDLE 583
SAE AR+LE ++E + E+ + +M ++ LQ+K+ + +
Sbjct: 1832 RELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYK 1891
Query: 584 TELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIK 629
++ + NQ + K K QH+ L EV+ E +E+Q +K
Sbjct: 1892 QQVEVAETQANQYLSKY-KKQQHE---LNEVKERAEVAESQVNKLK 1933
Score = 52.0 bits (123), Expect = 2e-06
Identities = 69/398 (17%), Positives = 166/398 (41%), Gaps = 35/398 (8%)
Query: 32 SESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSALNLK 91
+ES + + ++L K ELE L E + +E + TI+ + + + ++
Sbjct: 1566 NESKILHFQLELLEAKAELERKLSEKD---EEIENFRRKQQCTIDSLQSSLDSEAKSRIE 1622
Query: 92 ISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLE--NLTDNESENTNLKK 149
++ K+ + ++L+ ++ L+ R + +L + ++ +L ++T L
Sbjct: 1623 VTRLKKKMEEDLN-----EMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNS 1677
Query: 150 KVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKR----EAENDKLKE 205
+ E+ A + + L QSE + ++ + + E ++ +R +N L
Sbjct: 1678 DLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLS 1737
Query: 206 YVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLD---HFTGAIEK 262
K LE +A+ ++ E +E +++ + S+ K++ D H E
Sbjct: 1738 QKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTREN 1797
Query: 263 LTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQ-IETMKKQIINLLEDLKKMED 321
+ I D + +L+E E++ + + ++Q +E+ +++ LE +
Sbjct: 1798 MEQTITDLQKRLAEA-----------EQMALMGSRKQIQKLESRVRELEGELEGEIRRSA 1846
Query: 322 HGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKT 381
+ + R + + Y+ E ++++T + L+ + V+N +++ E +
Sbjct: 1847 EAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQ---LKVQNYKQQVEVAETQANQ 1903
Query: 382 LIEMYKTQVQKL---QEAAEIVKSRCENLLHKNNQITK 416
+ YK Q +L +E AE+ +S+ L K + K
Sbjct: 1904 YLSKYKKQQHELNEVKERAEVAESQVNKLKIKAREFGK 1941
Score = 40.8 bits (94), Expect = 0.004
Identities = 42/158 (26%), Positives = 75/158 (47%), Gaps = 20/158 (12%)
Query: 484 LLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEY 543
L+ + EE ++ +C LQ+ LE+ + + +EL+ K Q + N + AE
Sbjct: 851 LVKSSEVGEEVAGLKEECAQLQKALEKSEFQREELKAK---QVSLTQEKNDLILQLQAEQ 907
Query: 544 TALAR-------------QLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKN 590
LA QLEA ++E ++V EE E+++S +A K+ D EL+K+
Sbjct: 908 ETLANVEEQCEWLIKSKIQLEARVKELSERVEEE-EEINSELTARGRKLEDECFELKKEI 966
Query: 591 EEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESI 628
++ ++ K + + E +V+N E+ E NE I
Sbjct: 967 DDLETMLVKSEKEKRTTE---HKVKNLTEEVEFLNEDI 1001
Score = 38.1 bits (87), Expect = 0.025
Identities = 66/334 (19%), Positives = 138/334 (41%), Gaps = 42/334 (12%)
Query: 32 SESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSALNLK 91
S ++ LK+ + + E+E L A L + I+ + + + + LN
Sbjct: 1619 SRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSD 1678
Query: 92 ISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDN----ESENTNL 147
+ EQ + + +S LE L ++ + G LS L T+ ++NT+L
Sbjct: 1679 LKEQVAVAERRNSLLQS---ELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSL 1735
Query: 148 ---KKKV------FEKEAHIQELSCLFQSEKAN--TLKANRFSQSVK-----VVH----- 186
KKK+ +KEA C EKA ++A S+ +K + H
Sbjct: 1736 LSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTR 1795
Query: 187 ---ERLQIQIHKREAENDKL-----KEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQK 238
E+ + KR AE +++ ++ ++ LE+++ + + + + +R+
Sbjct: 1796 ENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRL 1855
Query: 239 TVALKKAS---KVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEK 295
+K+ + + K+ L ++KL ++++ + ++ + +N + S Y+K E
Sbjct: 1856 ERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHEL 1915
Query: 296 TELEVQIETMKKQIINLLEDLKKMEDHGKNSCEE 329
E++ + E + Q+ L K + GK EE
Sbjct: 1916 NEVKERAEVAESQVNKL---KIKAREFGKKVQEE 1946
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 98.6 bits (244), Expect = 2e-20
Identities = 124/613 (20%), Positives = 268/613 (43%), Gaps = 54/613 (8%)
Query: 47 KTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSALNLKISEQKEILIKELDTF 106
K L+ T +E EL ELL K T K+ E + + ++ E+K IL ++L
Sbjct: 842 KPLLQVTRQEEELQAKDEELLKVKEKQT--KVEGELEEMERKHQQLLEEKNILAEQLQAE 899
Query: 107 KSVKLALEHL-LRKRDYKQTGDNLSSMLLENLTDNESENTNLKKKVFEKEAHIQELSCLF 165
+ E + R KQ + + L + + E N L+ + + +AHIQ+L
Sbjct: 900 TELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQL 959
Query: 166 QSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNK 225
E+ ++LQ++ EA+ K++E + LE + +K+ + ++ +
Sbjct: 960 DEEEG--------------ARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLME 1005
Query: 226 NEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWK 285
+ + E S Q +KA + K R + I L +++ +E E A
Sbjct: 1006 DR---IAECSSQLAEEEEKAKNLAKIR-NKQEVMISDLEERLKKEEKTRQELEKAKRKLD 1061
Query: 286 SHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHG------KNSCEEILRKVHS--- 336
+ + EL+ QI+ +K Q+ E+L+ G KN+ +++R++ +
Sbjct: 1062 GETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIA 1121
Query: 337 -IEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQE 395
++ + E+ K + L +E+ +++ EL + + Q+ L + ++ QE
Sbjct: 1122 ELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQEL------RTKREQE 1175
Query: 396 AAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQE 455
AE+ K+ E + QI + ++ + ++ L++ +R +L ++ L +
Sbjct: 1176 VAELKKALEEETKNHEAQIQDMRQRHATALE-ELSEQLEQAKRFKANLEKNKQGLETDNK 1234
Query: 456 SLQC----CKGKCADQEHTIRELQGQVDGNHNLLT-----KLSLEEENCLIQLKCENLQQ 506
L C + A+ EH ++L QV H ++ ++ L E+ +Q + +N+
Sbjct: 1235 ELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVST 1294
Query: 507 KLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIE 566
LE+ + + + K A+ E L+ + +E++ + L+ ++ LEE + + E+ E
Sbjct: 1295 LLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIR-QLEEEKNSLQEQQE 1353
Query: 567 KMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSE---- 622
+ L+ ++L L+++L ++ + + + S + ++ LK+ + ++ E
Sbjct: 1354 EEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKAL 1413
Query: 623 --NQNESIKNYLQ 633
++ E KN LQ
Sbjct: 1414 AYDKLEKTKNRLQ 1426
Score = 95.9 bits (237), Expect = 1e-19
Identities = 139/691 (20%), Positives = 283/691 (40%), Gaps = 90/691 (13%)
Query: 13 ELFCHLKTISEKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFK 72
EL L T + +++L R E ++ LK+ + E EA +++ H+ L
Sbjct: 1154 ELEDTLDTTAAQQEL-RTKREQEVAELKKALEEETKNHEAQIQDMRQ-RHATAL--EELS 1209
Query: 73 DTIEKINFENANLSALNLKISEQKEILIKELDTFKSVKLALEHLLRKRDYK--------Q 124
+ +E+ ANL + + L E+ + VK EH +K D +
Sbjct: 1210 EQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVS 1269
Query: 125 TGDNLSSML------LENLTDN------ESENTNLK--KKVFEKEAHIQELSCLFQSEKA 170
GD L L L+N DN E+E +K K E+ +Q+ L Q E
Sbjct: 1270 EGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETR 1329
Query: 171 NTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAKW------------N 218
L + + ++ LQ Q + E L++ V +L++++A +
Sbjct: 1330 QKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIES 1389
Query: 219 LQSRMNK--NEAIVMKEASRQKTVALKKASKV---YKQRLDHFTGAIE---KLTSQIRDQ 270
L+ K +A + + +K +A K K +Q LD T ++ ++ S + +
Sbjct: 1390 LEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKK 1449
Query: 271 EAKLSETISASNAWKSHY----EKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGK-- 324
+ K + ++ + + Y ++ E E E + ++ + + LE ++ E K
Sbjct: 1450 QKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQL 1509
Query: 325 --------NSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVE 376
+S +++ + VH +E L + +++T L L+DE+ + E+ L+
Sbjct: 1510 RADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNM 1569
Query: 377 KKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKEL 436
+ K E + LQ E +N + + K V ++ ++E K+
Sbjct: 1570 QAMKAQFE------RDLQTRDE-----------QNEEKKRLLIKQVRELEAELEDERKQR 1612
Query: 437 ERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCL 496
S E L + + ++ + +R+LQ Q+ L + +
Sbjct: 1613 ALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIF 1672
Query: 497 IQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEE 556
Q K ++KL+ ++AE +L+++LA+ E +H+ + E + E T A A L+E
Sbjct: 1673 AQSK--ESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDE 1730
Query: 557 GRQ---KVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKE 613
R+ ++A+ E++ +S +++ L RK + V +N++ + ++
Sbjct: 1731 KRRLEARIAQLEEELEEEQSNMEL----LNDRFRKTTLQ----VDTLNAELAAERSAAQK 1782
Query: 614 VQNSLEKSENQNESIKNYLQFLKTSYVTMFE 644
N+ ++ E QN+ +K LQ L+ + + F+
Sbjct: 1783 SDNARQQLERQNKELKAKLQELEGAVKSKFK 1813
Score = 82.8 bits (203), Expect = 9e-16
Identities = 132/626 (21%), Positives = 262/626 (41%), Gaps = 102/626 (16%)
Query: 35 HLSCLKQDILNEKTELEATLKEAELVTHSVE----LLLPLFKDTIEKINFENANLSALNL 90
+LS + + EK L+ +E E ++E L DT +K++ + + +L
Sbjct: 1333 NLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLE- 1391
Query: 91 KISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESENTNLKKK 150
E K+ L+K+ + LE D + N L++LT + +
Sbjct: 1392 ---EAKKKLLKDAEALSQ---RLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASN 1445
Query: 151 VFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKL---KEYV 207
+ +K+ +K + L A S S + ER + + RE E L +
Sbjct: 1446 LEKKQ------------KKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALE 1493
Query: 208 KSLETK--IAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTS 265
++LE K + N Q R + + + K+ + L+K+ + +Q+ +E++ +
Sbjct: 1494 EALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQ-------VEEMRT 1546
Query: 266 QIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKN 325
Q+ + E +L T A K LEV ++ MK Q DL+ ++ +
Sbjct: 1547 QLEELEDELQATEDA--------------KLRLEVNMQAMKAQFER---DLQTRDEQNEE 1589
Query: 326 SCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQ-EVEKKQKTLIE 384
++++V +E E LE+ + + LA + +E +L +L+ ++E K E
Sbjct: 1590 KKRLLIKQVRELEAE-----LEDERKQRALAVASKK--KMEIDLKDLEAQIEAANKARDE 1642
Query: 385 MYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLT 444
+ K Q++KLQ + + E ++I ++K EK +E+ + +L+ S
Sbjct: 1643 VIK-QLRKLQAQMKDYQRELEEARASRDEIF-AQSKESEKKLKSLEAEILQLQEELASSE 1700
Query: 445 AAERRLHECQESL------------------QCCKGKCADQEHTIRELQGQVDGNHNLLT 486
A R + ++ L + + + A E + E Q ++ ++
Sbjct: 1701 RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFR 1760
Query: 487 KLSLEEENCLIQL--------KCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKE 538
K +L+ + +L K +N +Q+LE+ +NKEL+ KL E +K KFK
Sbjct: 1761 KTTLQVDTLNAELAAERSAAQKSDNARQQLER---QNKELKAKLQELEGAVKS---KFKA 1814
Query: 539 KSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVC 598
+ A QLE LE+ ++ A + + E L+ + +E E R ++ + Q+
Sbjct: 1815 TISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQME- 1873
Query: 599 KMNSKAQHQEVCLKEVQNSLEKSENQ 624
K N++ +K+++ LE++E +
Sbjct: 1874 KANAR-------MKQLKRQLEEAEEE 1892
Score = 37.4 bits (85), Expect = 0.043
Identities = 57/321 (17%), Positives = 128/321 (39%), Gaps = 43/321 (13%)
Query: 36 LSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSALNLKISEQ 95
L +D E E A+ E + E L + I ++ E A+ ++
Sbjct: 1650 LQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQE 1709
Query: 96 KEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESENTNLKKKVFEKE 155
++ L E+ S K AL D K+ + + L E L + +S L + +
Sbjct: 1710 RDELADEITNSASGKSAL------LDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTT 1763
Query: 156 AHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKRE-AENDKLKEYVKSLETKI 214
+ L+ +E++ K++ Q ++ ++ L+ ++ + E A K K + +LE KI
Sbjct: 1764 LQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKI 1823
Query: 215 AKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKL 274
+ Q +++ ++++ A K + K+ ++++ Q+ D+
Sbjct: 1824 GQLEEQ----------LEQEAKERAAANKLVRRTEKK--------LKEIFMQVEDE---- 1861
Query: 275 SETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKV 334
+ H ++ + + +++ +K+Q LE+ ++ S ++ R++
Sbjct: 1862 ----------RRHADQYKEQMEKANARMKQLKRQ----LEEAEEEATRANASRRKLQREL 1907
Query: 335 HSIEYENETLNLENTKLKTTL 355
NE L+ E + LK L
Sbjct: 1908 DDATEANEGLSREVSTLKNRL 1928
Score = 37.0 bits (84), Expect = 0.056
Identities = 79/355 (22%), Positives = 139/355 (39%), Gaps = 41/355 (11%)
Query: 40 KQDILNEKTELEATL----KEAELVTHSVELLLPLFKDTIEKINFENANLSALNLKISEQ 95
K+ ++ + ELEA L K+ L S + + KD A + A N E
Sbjct: 1591 KRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDL-------EAQIEAANKARDEV 1643
Query: 96 KEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESENTNLKKKVFEKE 155
+ L K K + LE RD S L++L E+E L++++ E
Sbjct: 1644 IKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSL---EAEILQLQEELASSE 1700
Query: 156 A---HIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLET 212
H ++ E N+ K RL+ +I + E E ++ + ++ L
Sbjct: 1701 RARRHAEQERDELADEITNSASGKSALLDEK---RRLEARIAQLEEELEEEQSNMELLND 1757
Query: 213 KIAKWNLQSRMNKNEAIVMKEASRQKTVA---LKKASKVYKQRLDHFTGAIE-KLTSQIR 268
+ K LQ E + A+++ A L++ +K K +L GA++ K + I
Sbjct: 1758 RFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATIS 1817
Query: 269 DQEAK---LSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKN 325
EAK L E + ++ K+V +TE ++ K+I +ED ++ D K
Sbjct: 1818 ALEAKIGQLEEQLEQEAKERAAANKLV-RRTEKKL------KEIFMQVEDERRHADQYKE 1870
Query: 326 SCE-------EILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQ 373
E ++ R++ E E N KL+ L + + E+S L+
Sbjct: 1871 QMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLK 1925
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 98.2 bits (243), Expect = 2e-20
Identities = 162/741 (21%), Positives = 296/741 (39%), Gaps = 173/741 (23%)
Query: 33 ESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLP------------LFKDTIEKINF 80
E S LK+DI +LE TL + E H+ E + + K T EK
Sbjct: 944 EDECSELKRDI----DDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKAL 999
Query: 81 ENANLSALN----------------LKISEQKEILIKELDTFKSVKLALEHLLRKR--DY 122
+ A+ AL+ +K+ +Q + L L+ K V++ LE RK D
Sbjct: 1000 QEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDL 1059
Query: 123 KQTGDNLSSM--------------------LLENLTDNESENTNLKKKVFEKEAHIQELS 162
K T +++ + L + D ++ + L+KK+ E +A I+EL
Sbjct: 1060 KLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELE 1119
Query: 163 CLFQSEKANTLKANRF----SQSVKVVHERLQ-------IQIH---KREAENDKLKEYVK 208
++E+ K + S+ ++ + ERL+ +QI KREAE K++ ++
Sbjct: 1120 EELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE 1179
Query: 209 SLETK-------IAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIE 261
+ + K + S E I + +QK L+K +K LD T +E
Sbjct: 1180 EATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQK---LEKEKSEFKLELDDVTSNME 1236
Query: 262 K--------------LTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKK 307
+ L Q+ + +K ET + N S K+ E EL Q++ +
Sbjct: 1237 QIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEA 1296
Query: 308 QIINL----------LEDLKKM---EDHGKNSCEEILRKVHSI------EYENETLNLEN 348
I L LEDLK+ E KN+ L+ +YE ET
Sbjct: 1297 LISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETE--AK 1354
Query: 349 TKLKTTLAALKDEVVSVENE-----LSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSR 403
+L+ L+ EV + + +E+E+ +K L + ++Q+ +EA E V ++
Sbjct: 1355 AELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ----RLQEAEEAVEAVNAK 1410
Query: 404 CENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGK 463
C +L KTK++ ++ ++E + ++ER + A +++ + L K K
Sbjct: 1411 CSSL-------EKTKHR----LQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQK 1459
Query: 464 CADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKC-----ENLQQKL---------- 508
+ + + Q + L KL E L L+ +NLQ+++
Sbjct: 1460 YEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSS 1519
Query: 509 -----------EQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEG 557
+Q++AE EL+ L E L+H K E+ + ++E
Sbjct: 1520 GKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE------ 1573
Query: 558 RQKVAEEIEKMSSRESALQIKILD-----LETELRKKNEEQNQLVCKMNSKAQHQEVCLK 612
+K+AE+ E+M + ++++D L+ E R +NE ++ KM E+ L
Sbjct: 1574 -RKLAEKDEEMEQAKRN-HLRVVDSLQTSLDAETRSRNEAL-RVKKKMEGDLNEMEIQLS 1630
Query: 613 EVQNSLEKSENQNESIKNYLQ 633
+++ Q +S+++ L+
Sbjct: 1631 HANRMAAEAQKQVKSLQSLLK 1651
Score = 92.4 bits (228), Expect = 1e-18
Identities = 173/751 (23%), Positives = 322/751 (42%), Gaps = 154/751 (20%)
Query: 12 EELFCHLKTISEKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLL--- 68
+EL ++ + E+ + R T+ + + L+ D+ E E+ L+EA T SV++ +
Sbjct: 1109 KELQARIEELEEELEAER-TARAKVEKLRSDLSRELEEISERLEEAGGAT-SVQIEMNKK 1166
Query: 69 ------PLFKDTIEKINFENANLSALNLKISEQKEILIKELDTFKSVKLALEHLLRKRDY 122
+ +D E A +AL K ++ L +++D + VK LE K ++
Sbjct: 1167 REAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEK--EKSEF 1224
Query: 123 KQTGDNLSSML----------------------------------LENLTDN----ESEN 144
K D+++S + + +LT ++EN
Sbjct: 1225 KLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTEN 1284
Query: 145 TNLKKKVFEKEAHIQELSC--LFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDK 202
L +++ EKEA I +L+ L +++ LK + + VK + L + + D
Sbjct: 1285 GELSRQLDEKEALISQLTRGKLTYTQQLEDLK-RQLEEEVKAKNA-LAHALQSARHDCDL 1342
Query: 203 LKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASR------QKTVALKKASKVYKQRLDHF 256
L+E + ET+ AK LQ ++K + V + ++ Q+T L++A K QRL
Sbjct: 1343 LREQYEE-ETE-AKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEA 1400
Query: 257 TGAIE--------------KLTSQIRDQEAKLSETISASNAW---KSHYEKIVIE----K 295
A+E +L ++I D + + +A+ A + +++KI+ E
Sbjct: 1401 EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKY 1460
Query: 296 TELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTL 355
E + ++E+ +K+ +L +L K+ KN+ EE L + + + EN+ L E + L L
Sbjct: 1461 EESQSELESSQKEARSLSTELFKL----KNAYEESLEHLETFKRENKNLQEEISDLTEQL 1516
Query: 356 AA-------LKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCEN-L 407
+ L+ +E E ELQ ++ + +E + ++ + Q +K+ E L
Sbjct: 1517 GSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKL 1576
Query: 408 LHKNNQITKTKNKNVE--------------------KMRGQMESHLKELERVCDSLTAAE 447
K+ ++ + K ++ +++ +ME L E+E L+ A
Sbjct: 1577 AEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEI---QLSHAN 1633
Query: 448 RRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSL-EEENCLIQLKCENLQQ 506
R E Q+ ++ + D T +L V N +L +++ E N L+Q + E L+
Sbjct: 1634 RMAAEAQKQVKSLQSLLKD---TQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA 1690
Query: 507 KLEQMDAENKELEKKLANQEE--CLKHS------NLKFKEKSAEYTALARQLEAALEEGR 558
+EQ + K E++L E L HS N K K+ A+ + L ++E A++E R
Sbjct: 1691 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQK-KKMDADLSQLQTEVEEAVQECR 1749
Query: 559 QKVAEEIEKMSSRESALQIKILDLE------TELRKKNEEQ------------NQLVCKM 600
AEE K + ++A+ + L E E KKN EQ Q+ K
Sbjct: 1750 N--AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKG 1807
Query: 601 NSK-AQHQEVCLKEVQNSLEKSENQN-ESIK 629
K Q E ++E++N LE + +N ES+K
Sbjct: 1808 GKKQLQKLEARVRELENELEAEQKRNAESVK 1838
Score = 79.3 bits (194), Expect = 1e-14
Identities = 99/443 (22%), Positives = 192/443 (43%), Gaps = 42/443 (9%)
Query: 205 EYVKSLETK----IAKWNLQSRMNKNE----AIVMKEASRQKTVALKKASKVYKQRLDHF 256
EY K LE + + +WN+++ M + K K+ +K K+
Sbjct: 800 EYKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAEREKEMASMKEEFTRL 859
Query: 257 TGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDL 316
A+EK ++ ++ E K+ + N + + + E + + + K I L +
Sbjct: 860 KEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKV 919
Query: 317 KKMEDHGKNSCE---EILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQ 373
K+M + ++ E E+ K +E E L + L+ TLA ++ E + EN++ L
Sbjct: 920 KEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLT 979
Query: 374 EVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHL 433
E +I + + LQEA + + K N +TK K K +E+ +E L
Sbjct: 980 EEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVK-LEQQVDDLEGSL 1038
Query: 434 KELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLS--LE 491
++ ++V L A+R+L + L+ + D E+ ++L ++ L L+ +E
Sbjct: 1039 EQEKKVRMDLERAKRKL---EGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIE 1095
Query: 492 EENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLE 551
+E L LQ+KL+++ A +ELE++L E + + K ++ ++ + ++
Sbjct: 1096 DEQAL----GSQLQKKLKELQARIEELEEEL----EAERTARAKVEKLRSDLSRELEEIS 1147
Query: 552 AALEEGRQKVAEEIEKMSSRESALQIKILDLE----------TELRKKNEEQNQLVCKMN 601
LEE + +IE RE+ Q DLE LRKK+ + V ++
Sbjct: 1148 ERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADS---VAELG 1204
Query: 602 SKAQHQEVCLKEVQNSLEKSENQ 624
+ + L+ V+ LEK +++
Sbjct: 1205 EQIDN----LQRVKQKLEKEKSE 1223
Score = 60.1 bits (144), Expect = 6e-09
Identities = 93/446 (20%), Positives = 185/446 (41%), Gaps = 62/446 (13%)
Query: 32 SESHLSCLKQDILN---EKTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSAL 88
S HL K++ N E ++L L + H +E + + EK+ ++A A
Sbjct: 1491 SLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLE--AEKMELQSALEEAE 1548
Query: 89 NLKISEQKEILIKELDTFKSVKLALEHLLR---------KRDYKQTGDNLSSMLLENLTD 139
E+ +IL +L+ F +K +E L KR++ + D+L + L + T
Sbjct: 1549 ASLEHEEGKILRAQLE-FNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSL-DAETR 1606
Query: 140 NESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAE 199
+ +E +KKK+ E + E+ +A + +S++ + + QIQ+
Sbjct: 1607 SRNEALRVKKKM---EGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRA 1663
Query: 200 NDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMK-EASRQ------------------KTV 240
ND LKE + +E + LQ+ + + A+V + E SR+ +
Sbjct: 1664 NDDLKENIAIVERRNNL--LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNT 1721
Query: 241 ALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEV 300
+L K L +E+ + R+ E K + I+ + +K + +
Sbjct: 1722 SLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKK----EQDTSA 1777
Query: 301 QIETMKKQIINLLEDLKKMEDH--------GKNSCEEILRKVHSIEYENET---LNLENT 349
+E MKK + ++DL+ D GK +++ +V +E E E N E+
Sbjct: 1778 HLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESV 1837
Query: 350 K-LKTTLAALKDEVVSVENE---LSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCE 405
K ++ + +K+ E + L LQ++ K + ++ YK Q ++ +E A S+
Sbjct: 1838 KGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFR 1897
Query: 406 NLLHKNNQITKTKN---KNVEKMRGQ 428
+ H+ ++ + + V K+R +
Sbjct: 1898 KVQHELDEAEERADIAESQVNKLRAK 1923
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 97.8 bits (242), Expect = 3e-20
Identities = 138/652 (21%), Positives = 277/652 (42%), Gaps = 74/652 (11%)
Query: 2 EKAVNDGSHSEELFCHLKTISEKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVT 61
+K + S E + HLK ++ R E H L+ +I +L + L E E
Sbjct: 375 QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEI----NQLHSKLLETERQL 430
Query: 62 HSVELLLPLFKD-TIEKINFENANLSALNLKISEQKEILIKELDTFKSVKLALEHLLRK- 119
L + + EK+ + ++ L LK+S +E L +++ L+H L K
Sbjct: 431 GEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN----STELQHQLDKT 486
Query: 120 RDYKQTGDNLSSMLLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFS 179
+ Q L L + +++ + +++ +K+ IQ L L Q K N
Sbjct: 487 KQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKEN-------- 538
Query: 180 QSVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKT 239
I E E + L +++ E + A N N ++E Q T
Sbjct: 539 -------------ISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHT----LQEQVTQLT 581
Query: 240 VALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELE 299
LK S+ +KQ ++ +++ + +R + ++ ++ N S + + ++L+
Sbjct: 582 EKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLD 641
Query: 300 VQIETMKKQIINL-------LEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLK 352
+QI+ + +++ DL+ D +N+ ++ + + LN T+L
Sbjct: 642 IQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQD----------KQQELNKITTQLD 691
Query: 353 TTLAALKDEVVSVENELSELQEVEKKQKTL---IEMYKTQVQKLQEAAEIVKSRCENLLH 409
A L+D+ S L+E ++K +L E + Q++KL+ + VK+ E L
Sbjct: 692 QVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQ 751
Query: 410 KNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEH 469
Q + N ++E ++ K+LE + +++ L + E+L+ K K QE
Sbjct: 752 DLQQ-QRQLNTDLELRATELS---KQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEE 807
Query: 470 TIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKEL---EKKLANQE 526
+ L+ + + TK+ EE N IQ LQ+ + +A EL + KL+
Sbjct: 808 EKQILKQDFE-TLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVS 866
Query: 527 ECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETEL 586
+ LK+S +F++++ + A LE +E + ++ ++E + +L+ L
Sbjct: 867 DSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQK-------ELKKSL 919
Query: 587 RKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTS 638
K+ E +QL ++NS + L + QN+L+++E + + ++ + LK S
Sbjct: 920 EKEKEASHQLKLELNSMQEQ----LIQAQNTLKQNEKEEQQLQGNINELKQS 967
Score = 93.6 bits (231), Expect = 5e-19
Identities = 133/664 (20%), Positives = 272/664 (40%), Gaps = 80/664 (12%)
Query: 11 SEELFCHLKTISE-KEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLP 69
+EEL I + K +L + ++ LK++++ +T ++ E E + +
Sbjct: 197 TEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKL----- 251
Query: 70 LFKDTIEKINFE----NANLSALNLKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQT 125
KD +K+ + A +S L ++++ + + + + +K ++ L +K
Sbjct: 252 --KDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQK------ 303
Query: 126 GDNLSSMLLENLTDNESENTNLKKKVFEKEAHIQELSC-LFQSEKANTLKANRFSQSVKV 184
+ L ENL E + T L++K E+ + + L Q + +R S S
Sbjct: 304 ----NQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETS 359
Query: 185 VHERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKK 244
+H R+ +++ ++ KLKE + +ETK + + + + +E Q + L+
Sbjct: 360 LH-RIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQ----REEKEQHGLQLQS 414
Query: 245 ASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIET 304
I +L S++ + E +L E + + +++K E Q+
Sbjct: 415 E--------------INQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDK---EQQVAD 457
Query: 305 MKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTK--------LKTTLA 356
++ ++ L E LK+ + + L K E + L T L+ L
Sbjct: 458 LQLKLSRLEEQLKEKVTNS-TELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLR 516
Query: 357 ALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITK 416
+ D+ ++N L L + K+ +L+E + + +A E + L KN+ + +
Sbjct: 517 QIGDKDQKIQN-LEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQE 575
Query: 417 TKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQE---SLQCCKGKCADQEHTIRE 473
+ EK++ Q ESH + E + D + + L Q+ SL+ + Q + +E
Sbjct: 576 QVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKE 635
Query: 474 LQGQVDGNHNLLTKLSLEEENC-------------LIQLKCENLQQKLEQMDAENKELEK 520
Q+D T+L L E Q ++ QQ+L ++ + ++
Sbjct: 636 KVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTA 695
Query: 521 KLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQ---- 576
KL +++E KE +Y +L ++ E + ++ A+ +E +S+E ALQ
Sbjct: 696 KLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQ 755
Query: 577 --IKILDLE---TELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNY 631
DLE TEL K+ E + ++V Q + L+ ++ L K E + + +K
Sbjct: 756 QRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQD 815
Query: 632 LQFL 635
+ L
Sbjct: 816 FETL 819
Score = 93.2 bits (230), Expect = 7e-19
Identities = 155/697 (22%), Positives = 292/697 (41%), Gaps = 139/697 (19%)
Query: 2 EKAVNDGSHSEELFCHLKTISEKEDLPRCTSESHLSCLKQ------DILNEKTELEATLK 55
EK ++ +EEL +K + + + E L L+Q D+ TEL L+
Sbjct: 716 EKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLE 775
Query: 56 EAELVTHSVELLLPLFKDTIEKINFENANLSALNLKISEQKEILIKELDTF--------- 106
+ + S L L + +E I + K E+K+IL ++ +T
Sbjct: 776 MEKEIVSSTRLDLQKKSEALESIKQKLT-------KQEEEKQILKQDFETLSQETKIQHE 828
Query: 107 -------------KSVKLALEHLLRKRD-YKQTGDNLSSMLLENLTDNESENTNLKKKVF 152
+ VK+ E L+ + K +S L + ++ E EN K +
Sbjct: 829 ELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAIL 888
Query: 153 EKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLET 212
+ E +EL Q + NTLK + L+ + K + + +LK + S++
Sbjct: 889 DLEKTCKELKHQLQVQMENTLKEQK----------ELKKSLEKEKEASHQLKLELNSMQE 938
Query: 213 KIAKWNLQSRMNKNEAIVMKEASRQKTV-ALKKASKVYKQRLDHFTGAIEKLTSQIRDQE 271
++ + Q+ + +NE +E Q + LK++S+ K++++ G ++ Q + E
Sbjct: 939 QLIQ--AQNTLKQNEK---EEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELE 993
Query: 272 AKLSETIS-ASNAWKSHYEKIVIEKTELEVQIETMKK----------QIINLLEDLKKME 320
KL + ++ A+ + EKI + + E ET K+ +++ +DLK +E
Sbjct: 994 NKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVE 1053
Query: 321 DHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSE----LQEVE 376
+ + E+++ + I +N+ + +LKT A L+ + E +L E LQ+++
Sbjct: 1054 EKLSLAQEDLISNRNQIGNQNKLIQ----ELKTAKATLEQDSAKKEQQLQERCKALQDIQ 1109
Query: 377 KKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKEL 436
K+K+L E K V + + AEI + +C + K + K+ +++SH E
Sbjct: 1110 -KEKSLKE--KELVNEKSKLAEIEEIKCR------------QEKEITKLNEELKSHKLES 1154
Query: 437 ERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCL 496
+ +L A++ L Q+ L ELQG+ D K ++E+E
Sbjct: 1155 IKEITNLKDAKQLL--IQQKL---------------ELQGKADS-----LKAAVEQEK-- 1190
Query: 497 IQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKE----KSAEYTALARQLEA 552
N Q +Q+ E +EL+K+ +E L HS +K KE K E A
Sbjct: 1191 -----RNQQILKDQVKKEEEELKKEFIEKEAKL-HSEIKEKEVGMKKHEENEAKLTMQIT 1244
Query: 553 ALEEGRQKVAEEIEKMSSRESALQIKILDLETELR------KKNEEQNQLVCKMNSKAQH 606
AL E V +E + R S L+ + DL E+ + N+++ + + + K +
Sbjct: 1245 ALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEG 1304
Query: 607 Q----EVCLKEVQNSLEKS---------ENQNESIKN 630
+ + + E+Q L+ + ENQ+ IK+
Sbjct: 1305 EIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKH 1341
Score = 60.1 bits (144), Expect = 6e-09
Identities = 70/302 (23%), Positives = 136/302 (45%), Gaps = 32/302 (10%)
Query: 352 KTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAE--------IVKSR 403
++ LA +D+V + E+ +LQ K++K E K +++K Q + + S
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 404 CE-NLLHKNNQITKTKNKNVEKMRGQMESHLKEL-ERVCD--SLTAAERRLHECQESLQC 459
E L + + +T+N N+++M+ E +L + D S ER L E E
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194
Query: 460 CKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELE 519
+ ++E T+ + D LL + +E+ +++ + +Q ++ M E +
Sbjct: 195 RLTEELNKEATVIQ-----DLKTELLQRPGIEDV-AVLKKELVQVQTLMDNMTLERERES 248
Query: 520 KKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVA---EEIEKMSSRESALQ 576
+KL ++EC K + + A A QL + L +G Q+VA +E++K+ S + L
Sbjct: 249 EKL--KDEC-----KKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELT 301
Query: 577 IKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLK 636
K L L KK ++ K+ K + V K +Q +L + + + +++ L +
Sbjct: 302 QKNQTLTENLLKKEQDYT----KLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASE 357
Query: 637 TS 638
TS
Sbjct: 358 TS 359
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 97.8 bits (242), Expect = 3e-20
Identities = 144/671 (21%), Positives = 299/671 (44%), Gaps = 101/671 (15%)
Query: 39 LKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFE---NANLSALNLKISEQ 95
L + I++ + EL + K+ ++ V+ + + I +++ + N +K+S +
Sbjct: 868 LNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNE 927
Query: 96 KEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSML---LENLTD--NESENTNLKKK 150
E + + S ++ L H K D +T D++S + L NL D N SE NL
Sbjct: 928 IETATRSITNNVS-QIKLMHT--KIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNT 984
Query: 151 VFE------------KEAHIQE----------LSCLFQSEKANTLKANRFSQSVKVVHER 188
+ KE IQE + +++ K +++ S + E
Sbjct: 985 QLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQI----EE 1040
Query: 189 LQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIV--MKEASRQKTVALKKAS 246
L+ QI K +AE K+ L+ K K N + + E ++ +KE ++K V L
Sbjct: 1041 LEQQIEKLQAEVKGYKDENNRLKEKEHK-NQDDLLKEKETLIQQLKEELQEKNVTLD--- 1096
Query: 247 KVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWK---SHYEKI---VIEKTELEV 300
V Q + A+ +LT + +AK+ E + K SH K+ ++EK + +
Sbjct: 1097 -VQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIIL 1155
Query: 301 QIETMKKQIINLLED--------------LKKMEDHGKNSCEEILRKVHSIEYENETLNL 346
++E K+ L+D LK+ N+ +++ + E E ET
Sbjct: 1156 KLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQ 1215
Query: 347 ENTKLKTTLAA-------LKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEI 399
E KLK L+A LK ++ E + ++L+E K I+ + +V +++ ++
Sbjct: 1216 ETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKL 1275
Query: 400 VKSRCENLLHKNNQITKT---KNKNVEKMRGQM-----ESHLKELERVCDSLTAAERRLH 451
++ + L K NQ ++ K + +++++ Q+ E +++ ER C L E+ +
Sbjct: 1276 LRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIE 1335
Query: 452 ECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQM 511
+ + +L+ + +Q+ L+ +++ L T+L +E C L+ +N Q+ ++
Sbjct: 1336 DMRMTLEEQEQTQVEQDQV---LEAKLEEVERLATELEKWKEKCN-DLETKNNQRSNKEH 1391
Query: 512 DAENKELEKKLANQEECLKHSNLKFK-------EKSAEYTALARQLEAALEEGRQKVAEE 564
+ N ++ KL N ++ L+ S K+ E+ A++ E + +K AE+
Sbjct: 1392 E-NNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAED 1450
Query: 565 IEKMSSRESALQI---KILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKS 621
E+ +++ ++I ++ + +++L+K EE++QLV + E+ LK + +S +
Sbjct: 1451 RERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAAL-------EIQLKALISSNVQK 1503
Query: 622 ENQNESIKNYL 632
+N+ E +K +
Sbjct: 1504 DNEIEQLKRII 1514
Score = 87.8 bits (216), Expect = 3e-17
Identities = 155/686 (22%), Positives = 303/686 (44%), Gaps = 107/686 (15%)
Query: 23 EKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFEN 82
E E+ C E + +K ++ K EL T +E + + + L+ + + +KI +N
Sbjct: 665 ETEEATACL-ELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQN 723
Query: 83 ANLSALNLKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNL-SSMLLENLT--- 138
+ L + I +QKE I E F+++K +E+ + D T + ++ L+ N T
Sbjct: 724 QRIKEL-INIIDQKEDTINE---FQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEV 779
Query: 139 --DNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQ-IHK 195
D++S+ + +K+V E E E S ++ +S +V +I+ I
Sbjct: 780 PKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRV 839
Query: 196 REAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEA----SRQKTVALKKASKVYKQ 251
+ N+ L+ ++ ++E ++ K + + N+ IV + S +K + L K + +
Sbjct: 840 LQENNEGLRAFLLTIENEL-KNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQS 898
Query: 252 RLDHFTGAIEKLTSQIRDQEAKL----SETISASNAWKSHYEKIVIEKTELEVQIETMKK 307
D + S+ ++QE K+ +E +A+ + ++ +I + T+++ ++ T+
Sbjct: 899 NYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKID-ELRTLDS 957
Query: 308 --QIINL----LEDLKK--MEDHGKNSCEEILRKVHSI-----EYENETLNLENTKLKTT 354
QI N+ L DL ED+ N+ ++L + + EY + N EN+
Sbjct: 958 VSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENS----- 1012
Query: 355 LAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVK---SRCENLLHKN 411
+ ++ E E+ + K+ IE + Q++KLQ + K +R + HKN
Sbjct: 1013 ---FHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKN 1069
Query: 412 -NQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHT 470
+ + K K +++++ +++ L+ + +R L E + + C K K + E T
Sbjct: 1070 QDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELE-T 1128
Query: 471 IRELQGQVDGNHNL-LTKLSLEEENCLIQLKC------ENLQQKLEQM-DAENKELEKK- 521
I E Q +V+ +H+ L + LE+E+ +++L+ E+LQ ++ D KEL+ K
Sbjct: 1129 ILETQ-KVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKE 1187
Query: 522 ----LANQEECLKH------------------------------SNLK--FKEKSAEYTA 545
L N + +KH NLK + K +Y
Sbjct: 1188 EITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYAD 1247
Query: 546 LARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQ 605
L +L A ++ +Q V +E+ M + L+IKI +LE +KKN+ +L K + Q
Sbjct: 1248 LKEKLTDAKKQIKQ-VQKEVSVMRDEDKLLRIKINELE---KKKNQCSQELDMKQRTIQQ 1303
Query: 606 HQEVCLKEVQNSLEKSENQNESIKNY 631
LKE N ++ E+I+ Y
Sbjct: 1304 -----LKEQLN----NQKVEEAIQQY 1320
Score = 71.2 bits (173), Expect = 3e-12
Identities = 123/575 (21%), Positives = 245/575 (42%), Gaps = 109/575 (18%)
Query: 49 ELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSALNLKISEQKEILIKELDTFKS 108
E + +K + +H +E L + IEK+ E N ++ E++ + D K
Sbjct: 1023 ECKEIVKASSKKSHQIEEL----EQQIEKLQAEVKGYKDENNRLKEKEHK--NQDDLLKE 1076
Query: 109 VKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSE 168
+ ++ L K + ++ L + ++++ + + + L + V +A I+EL + +++
Sbjct: 1077 KETLIQQL--KEELQEKNVTLD-VQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQ 1133
Query: 169 KANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEA 228
K + + Q + + E + +++ + LKE+ + L+ + +N E
Sbjct: 1134 KVECSHSAKLEQDI-LEKESIILKLERN------LKEFQEHLQDSVKN---TKDLNVKE- 1182
Query: 229 IVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHY 288
+ +KE Q T L Q + H E+ R + KL E +SAS+A +
Sbjct: 1183 LKLKEEITQLTNNL--------QDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNL 1234
Query: 289 EKIVIEKTE----LEVQIETMKKQIINLLEDLKKMEDHGK-------------NSC-EEI 330
+ + K E L+ ++ KKQI + +++ M D K N C +E+
Sbjct: 1235 KADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQEL 1294
Query: 331 LRKVHSIEYENETLNLENTKLKTTLAA---------LKDEVVS-VENELSELQEVEKKQK 380
K +I+ E LN N K++ + +K++++ + L E ++ + +Q
Sbjct: 1295 DMKQRTIQQLKEQLN--NQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQD 1352
Query: 381 TLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVC 440
++E +V++L E K +C +L KNNQ + +++N + G++ + EL
Sbjct: 1353 QVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDEL---- 1408
Query: 441 DSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLI--Q 498
QES Q +N K LEE+ LI
Sbjct: 1409 -------------QESEQ----------------------KYNADRKKWLEEKMMLITQA 1433
Query: 499 LKCENLQQKLEQMDAENKELEKKLANQEECL------KHSNLK--FKEKSAEYTALARQL 550
+ EN++ K + AE++E K N+ E L K S+L+ +E+ AL QL
Sbjct: 1434 KEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQL 1493
Query: 551 EAALEEGRQK--VAEEIEKMSSRESALQIKILDLE 583
+A + QK E+++++ S S ++ +I+D++
Sbjct: 1494 KALISSNVQKDNEIEQLKRIISETSKIETQIMDIK 1528
Score = 58.2 bits (139), Expect = 2e-08
Identities = 104/488 (21%), Positives = 193/488 (39%), Gaps = 63/488 (12%)
Query: 196 REAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYK----- 250
+ +E K +++V E+K+ + QS N I M Q +A + V K
Sbjct: 418 KNSEKSKFQQHVPFRESKLTHY-FQSFFNGKGKICMIVNISQCYLAYDETLNVLKFSAIA 476
Query: 251 QRL---DHFTGAIEKLTSQIRDQE---------AKLSETISASNAWKSHYEKIVIEKT-- 296
Q++ D + EKL ++ + +K+ A+ +W++ E ++ ++
Sbjct: 477 QKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATISWENSLEDLMEDEDLV 536
Query: 297 -ELEVQIETMKKQIINLLEDLKKMEDHGKN--SCEEILRKVHSIEYENETLNLENTKLKT 353
ELE ET + L EDL K + K S EE + + IE + L E + T
Sbjct: 537 EELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLT 596
Query: 354 TLAALKDEVVSV-------------ENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIV 400
+++EV E L E + +E+ + + ++K V K E
Sbjct: 597 LEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAA 656
Query: 401 KSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCC 460
K C + + + T +++ ++ EL + + L E + L+
Sbjct: 657 KDICATKV-ETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETS 715
Query: 461 KGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCEN--------LQQKL---- 508
K Q I+EL +D + + + + + KC + + KL
Sbjct: 716 NKKIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNE 775
Query: 509 ---EQMDAENKEL-EKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAE- 563
D+++K E+K N+ E L+ K+ S ++ + + EE R +AE
Sbjct: 776 TVEVPKDSKSKICSERKRVNENE-LQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEI 834
Query: 564 -EIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQH--QEVCLKEVQN-SLE 619
+I + L+ +L +E EL+ + EE+ +L N + H QE+ L E +N +L
Sbjct: 835 EDIRVLQENNEGLRAFLLTIENELKNEKEEKAEL----NKQIVHFQQELSLSEKKNLTLS 890
Query: 620 KSENQNES 627
K Q +S
Sbjct: 891 KEVQQIQS 898
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 97.4 bits (241), Expect = 4e-20
Identities = 174/774 (22%), Positives = 324/774 (41%), Gaps = 167/774 (21%)
Query: 22 SEKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELV------------THSVEL--- 66
SE ++L +C SE L KQ ++ EKT++E+ +++ L +H+ EL
Sbjct: 1956 SEMKNLKKCVSE--LEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQEL 2013
Query: 67 -------LLPLFKDTI---EKINFENANLSALNLKISE-QKEILIKELDTFKSVKLALEH 115
+ L KD I EKI+ + AL +E QK++ I + + ++V+ +
Sbjct: 2014 LKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKA 2073
Query: 116 LLRKRDYKQTGDNLSSMLLENLTDN-----------ESENTNLKKKVFEKEAHIQELSCL 164
+K D+ S L DN ES + +K+K + E +++
Sbjct: 2074 QAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEK 2133
Query: 165 FQSEKANTLKANRFSQSVKVVHER----LQIQIHKREAENDKLKEYVKSLETKIA----- 215
EK N + + KV E +Q+ ++K++ E +L+E + S T++A
Sbjct: 2134 HLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKS 2193
Query: 216 ----------------KWN------LQS-----RMNKNEAIVMKEASRQKTVALKKASKV 248
KW +QS R+ ++ V+K+ RQ ++ +++ K+
Sbjct: 2194 MSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEEL-KI 2252
Query: 249 YKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNA--------WKSHYEKIVIEKTELEV 300
RL+H E + K+ +T+ N + Y E +LE
Sbjct: 2253 NISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLES 2312
Query: 301 QIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHS------IEYE-------------- 340
+++++K Q+ +L L+K ++ K + E I+R+ + YE
Sbjct: 2313 ELKSLKDQLTDLSNSLEKCKEQ-KGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTS 2371
Query: 341 --NETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAE 398
+E +N++ K+ + L+ K+E + V ++EL++ K+ I+ + + + +E
Sbjct: 2372 RLHEEINMKEQKIISLLSG-KEEAIQVA--IAELRQQHDKE---IKELENLLSQEEEENI 2425
Query: 399 IVKSRCENLLHKNNQITKT----KNKNVEKMRGQMESHLKELER--------VCDSLTAA 446
+++ + + K NQ+ +T K +N+++ + Q++S +K + V D
Sbjct: 2426 VLEEENKKAVDKTNQLMETLKTIKKENIQQ-KAQLDSFVKSMSSLQNDRDRIVGDYQQLE 2484
Query: 447 ERRLHECQESLQCCKGKCADQ---EHTIRELQGQVDGNHNLLTKLSLE------EENCLI 497
ER L E Q + A+ + IR L+ +D ++ KL E + N +I
Sbjct: 2485 ERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVI 2544
Query: 498 QLKCENLQQKLEQMDAENKELEKKLANQEECLKHS-----------NLKFKEK------- 539
+K +Q LE +NKELE K A EE LK S N +EK
Sbjct: 2545 TIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEI 2604
Query: 540 ---SAEYTALARQLEAALEEG-------RQKV-AEEIEKMSSRESALQIKILDLETELRK 588
+ L RQ+ A EEG + KV EE+ ++S+ S+ Q +I +LE EL
Sbjct: 2605 ESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVC 2664
Query: 589 KNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSYVTM 642
+E + V ++ K + + LK + + N+ E+ + + L V M
Sbjct: 2665 VQKEAAKKVGEIEDKLKKE---LKHLHHDAGIMRNETETAEERVAELARDLVEM 2715
Score = 83.2 bits (204), Expect = 7e-16
Identities = 140/697 (20%), Positives = 310/697 (44%), Gaps = 99/697 (14%)
Query: 19 KTISEKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKI 78
K++ E+ L R T E L + + + ++++ A KE + V + LL I ++
Sbjct: 1500 KSLQEELSLARGTIER----LTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEM 1555
Query: 79 N---FENANLSAL--NLKIS-----EQKEILIKELDTFKSVKLA------LEHLLRKRDY 122
+ EN +LS+ +LK++ E KE L+KE+++ KS K+A +H +++Y
Sbjct: 1556 DRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEY 1615
Query: 123 K---QTGDNLSS------MLLENLTDNESE------NTNLKKKVFEKEAHIQELSCLFQS 167
+ Q+ +N+S+ ++E + + E +T KK EK+ E
Sbjct: 1616 EILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMK 1675
Query: 168 EKANTLKANRFSQSVKVVHE--RLQIQIHKRE-----------AENDKLKEYVK--SLET 212
EK ++ + +++ E RL+ ++H + N +KE ++ +E
Sbjct: 1676 EKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEY 1735
Query: 213 KIAKWNLQSRMNKNEAI--------------VMKEASRQKTVALKKASKVYKQRLDHFTG 258
+ QS M++ +++ V K+A+ + T + V ++ G
Sbjct: 1736 ETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPG 1795
Query: 259 AIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELE---VQIETMKKQIINLLED 315
E+ S SE++ ++ + K E+ QI+ +K++I L E+
Sbjct: 1796 ETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEE 1855
Query: 316 LKKMEDHG---KNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSEL 372
+K ++ +N +L ++ + + E + L E TK+ +++E+ + +++L
Sbjct: 1856 KQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEEL----SRVTKL 1911
Query: 373 QEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHK--NNQITKTKNKNVEKMRGQME 430
+E +++K +E + + +L E + + C+++ N++ +++ KN++K ++E
Sbjct: 1912 KETAEEEKDDLE--ERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELE 1969
Query: 431 SHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSL 490
++L + + + R+ E E +Q + + ++ H +ELQ + + +L
Sbjct: 1970 EEKQQLVKEKTKVESEIRK--EYLEKIQGAQKEPGNKSHA-KELQELLKEKQQEVKQL-- 2024
Query: 491 EEENCL-IQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQ 549
+++C+ Q K L++ ++ ++ E +K L +E L + K+ AE +
Sbjct: 2025 -QKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVL 2083
Query: 550 LEAALEEGRQKVAEEI----EKMSSRESA-LQIKILDLETELRKKNEEQNQLVCKMNSKA 604
L+ E + +A+ + E S++ES Q+K D + E R + E+ L K N +
Sbjct: 2084 LDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQE 2143
Query: 605 Q---------HQEVCLKEVQNSLEKSENQNESIKNYL 632
+ H E + E+Q +L K + + + ++ L
Sbjct: 2144 KLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENL 2180
Score = 79.3 bits (194), Expect = 1e-14
Identities = 147/677 (21%), Positives = 286/677 (42%), Gaps = 96/677 (14%)
Query: 25 EDLPRCTSESHLSCLKQDIL-NEKTELEATLKEAELVTHSVELLLPLFKDTI----EKIN 79
E + + E+ +K ++L NE +++ E + S++ L + + E++
Sbjct: 796 EQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVR 855
Query: 80 FENANLSALNLKISEQKEILIKELDTFKSVKL----ALEHLLRKRDYKQTGDNLSSMLLE 135
++ + L+ +S QKE+ I ++D K L+ + ++D + T +S + E
Sbjct: 856 HISSKVEELSQALS-QKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVT--EISFSMTE 912
Query: 136 NLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERL----QI 191
+ E +L ++ + + LS +++K + N S +K ++ + QI
Sbjct: 913 KMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQI 972
Query: 192 QIHKREAENDKLKEYVKSLETKIAKWNLQSRM-NKNEAIVMKEASRQKTVALKKASKVYK 250
+ + E D LK+ E + K LQ+ + N+ E + ++ LK SK
Sbjct: 973 SKEELQHEFDLLKK-----ENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEI 1027
Query: 251 QRLDHFTGAIEK-----------LTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELE 299
+ G +E+ +TS+ ++ E L +TIS H K + EK E
Sbjct: 1028 PLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAE 1087
Query: 300 VQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLK--TTLAA 357
Q + + KQ+ L+D N + + ++ + + L NT ++A
Sbjct: 1088 EQFQALVKQMNQTLQD-------KTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVAL 1140
Query: 358 LKDEVVSVE--NELSELQEVEKKQKTL-IEMYKTQVQ-KLQEA----AEIVKSRCENLLH 409
+K+ VV SE + E ++K L +E K Q+Q KLQEA I+K E H
Sbjct: 1141 VKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERH 1200
Query: 410 KNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHEC----------QESLQC 459
++ + K+ + +++ Q + KE E + D L + ++ E QES
Sbjct: 1201 LREELKQQKD-DYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSS 1259
Query: 460 CKG------KCADQEHTIRELQGQV--DGNHNLLTKLSLEEENCLIQLKCENLQQKLEQM 511
G K +Q HT L+ + D + +L+ + Q+K + L+++
Sbjct: 1260 TPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQ-----LKEI 1314
Query: 512 DAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQL-EAALE-EGRQKVAEEIE--- 566
+AE ELE K+++ + + +KS E L Q+ + LE E + V+ E E
Sbjct: 1315 EAEKVELELKVSS-------TTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHA 1367
Query: 567 ---KMSSRESALQIKILDLETELRKKNEEQNQLVCK-------MNSKAQHQEVCLKEVQN 616
+ S LQI L+ EL+ K +E +L+ K ++ + +E L ++Q
Sbjct: 1368 ESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQT 1427
Query: 617 SLEKSENQNESIKNYLQ 633
+ + E+ +++ L+
Sbjct: 1428 EIIEQEDLIKALHTQLE 1444
Score = 77.0 bits (188), Expect = 5e-14
Identities = 148/704 (21%), Positives = 294/704 (41%), Gaps = 127/704 (18%)
Query: 39 LKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSALNLKISEQKEI 98
LKQ I ++ EL+ K+ E + E L K + + + + L +ISE + I
Sbjct: 1062 LKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAI 1121
Query: 99 LIK------ELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESENTNLKKKVF 152
+ K + SV L E ++ + ++ L E + E E L+KK+
Sbjct: 1122 IQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKL- 1180
Query: 153 EKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLET 212
+EA + L ++++ Q K + RLQ Q ++ EN+ + + ++ L+
Sbjct: 1181 -QEALTSRKAILKKAQEKERHLREELKQQ-KDDYNRLQEQFDEQSKENENIGDQLRQLQI 1238
Query: 213 KIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEA 272
++ + ++ ++ + ++ S T L++ ++K H T + L S +
Sbjct: 1239 QVRE-SIDGKLPSTD----QQESCSSTPGLEEP--LFKATEQHHTQPV--LESNLCPDWP 1289
Query: 273 KLSETISASNAW------KSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDH-GKN 325
SE SA K+ ++I EK ELE+++ + ++ E++ ++++ K
Sbjct: 1290 SHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQ 1349
Query: 326 SCE-EILRKV-HSIEYENETLN--LENTKLKTT-----------------LAALKDEVVS 364
E E L+ V H E E+L LE+++L+ L + K+E VS
Sbjct: 1350 GLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVS 1409
Query: 365 ---------------VENELSELQEVEKKQKTLIEM----YKTQVQKLQ-EAAEIVK--- 401
++ E+ E +++ K T +EM + ++++LQ E E+ +
Sbjct: 1410 YLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPE 1469
Query: 402 -----SRCENLLHKNNQITKTKNKNVEKMRGQMESHLK----ELERVCDSLTAAERRLHE 452
SR + + + Q K K ++ L +ER+ SL E ++
Sbjct: 1470 EIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSA 1529
Query: 453 CQESLQCCKGKCA----DQEHTIRELQGQVDGNHNLLT-----KLSLE----EENCLIQ- 498
+ G+ A +++ I E+ + N +L + KL+LE ++ L++
Sbjct: 1530 QNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKE 1589
Query: 499 ---LKCENLQQKLEQMDAENKELEKK----------LANQEECLKHSNLKFKEKSAEYTA 545
LK + + E + ++KEL+K+ ++N+ E ++H +++ E
Sbjct: 1590 IESLKSSKIAESTEWQE-KHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYG 1648
Query: 546 LARQLEA-------ALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVC 598
R EA L+E Q++ E EKM + Q KIL+LE EE ++L
Sbjct: 1649 KLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELE-------EENDRLRA 1701
Query: 599 KMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSYVTM 642
+++ + C++ + +S N S+K L+ +K Y T+
Sbjct: 1702 EVHPAGDTAKECMETLLSS-------NASMKEELERVKMEYETL 1738
Score = 75.1 bits (183), Expect = 2e-13
Identities = 114/581 (19%), Positives = 253/581 (43%), Gaps = 61/581 (10%)
Query: 94 EQKEILIKELDTFKSVKLALEHLLRK--RDYKQTGDNLSSMLLENLTDNESENTNLKKKV 151
E KE+L +L+ + + + ++ L K + K D L+ L +L + + NL+ +
Sbjct: 2285 ENKELL-SQLEETRHLYHSSQNELAKLESELKSLKDQLTD-LSNSLEKCKEQKGNLEGII 2342
Query: 152 FEKEAHIQELSCLFQSEKANT-LKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSL 210
++EA IQ F E+ T L+A+R + +HE + + K + L +++
Sbjct: 2343 RQQEADIQNSK--FSYEQLETDLQASR--ELTSRLHEEINM---KEQKIISLLSGKEEAI 2395
Query: 211 ETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQ 270
+ IA+ Q E + ++ + L++ +K + + ++ + + Q
Sbjct: 2396 QVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQ 2455
Query: 271 EAKLSETISASNAWKSHYEKIVIEKTELE---VQIETMKKQIIN--------LLEDLKKM 319
+A+L + + ++ ++ ++IV + +LE + I K Q+I L E+++ +
Sbjct: 2456 KAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGL 2515
Query: 320 EDHGKN-SCEEILRKVHSIEYE---NETLNLENTKLKTTLAALKDEVVSVENELSELQEV 375
H + + E I+Y N+ + +++++ K L + +EN+ ++L+E
Sbjct: 2516 RSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEK 2575
Query: 376 EKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEK-----MRGQME 430
K+ + E + LQE + + E+L +Q+T+ E+ Q++
Sbjct: 2576 LKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLK 2635
Query: 431 SHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRE-LQGQVDGNHNLLTKL- 488
+E+ R+ +++++R+ E +E L C + + A + I + L+ ++ H+ +
Sbjct: 2636 VKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMR 2695
Query: 489 ----SLEEENCLIQLKCENLQQKLEQMDAENKELE-------KKLANQEECLKHSNLKFK 537
+ EE + ++QKL + ENK L + +++ + H+N +
Sbjct: 2696 NETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELD 2755
Query: 538 EKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQL- 596
E +Y A ++L E+G + +RE + ET + E+N L
Sbjct: 2756 ELKRKYDASLKELAQLKEQG----------LLNRERDALLS----ETAFSMNSTEENSLS 2801
Query: 597 -VCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLK 636
+ K+N + ++ L + + LE S NQ +S + L+
Sbjct: 2802 HLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQ 2842
Score = 66.6 bits (161), Expect = 7e-11
Identities = 105/578 (18%), Positives = 239/578 (41%), Gaps = 84/578 (14%)
Query: 90 LKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESENTNLKK 149
L +EQ + +K++ K V+L + + + K + + + L +++ T+L K
Sbjct: 54 LAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHA----KAKLTSLNK 109
Query: 150 KVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKS 209
+ E +A + + K ++ S ++ E+++ HK + + + +
Sbjct: 110 YIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIK---HKLQEKEELISTLQAQ 166
Query: 210 LETKIAKWNLQSRMNKNEAIVMKEASRQK-------------TVALKKASKVYKQRLDHF 256
L A+ QS E ++MK+ ++K T A + A +V +++ F
Sbjct: 167 LTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARF 226
Query: 257 TGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETM--KKQIINLLE 314
+Q+R E +L + ++ ++ +K+ + + +LE E++ + Q+++LL+
Sbjct: 227 E-------TQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQ 279
Query: 315 DLKKMEDHGKNSCEEILRKV--------HSIEYENETLNLENTKLKTTLAALKDEVVSVE 366
+ + L+++ +++E E E + K++ +A K +++
Sbjct: 280 QELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQ 339
Query: 367 NELSELQE------------------VEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLL 408
E+ L E +E+K K +E + + LQ+ + ++S C+ L
Sbjct: 340 EEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALK 399
Query: 409 HKNNQITKTKN-------KNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQ--- 458
+N+++ + KN + ++++ Q++ KE+ + + L + HE
Sbjct: 400 DQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQ---HETASQTSFPD 456
Query: 459 -CCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKE 517
+G A E I LQ +V + LE E + L +LE++ AEN++
Sbjct: 457 VYNEGTQAVTEENIASLQKRV---------VELENEKGALLLS----SIELEELKAENEK 503
Query: 518 LEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQI 577
L ++ E + + +A + ++ EE Q V E S + L +
Sbjct: 504 LSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLE--NTFSQKHKELSV 561
Query: 578 KILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQ 615
+L+++ + + QL K +A H+ + KE++
Sbjct: 562 LLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMK 599
Score = 57.4 bits (137), Expect = 4e-08
Identities = 96/439 (21%), Positives = 180/439 (41%), Gaps = 70/439 (15%)
Query: 218 NLQSRMNKNEAIV--MKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLS 275
++Q R+ E +V +K+ RQK V L++ + ++ I+KL + AKL
Sbjct: 49 DVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAK---AKL- 104
Query: 276 ETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLL----EDLKKMEDHGKNSCEEIL 331
T L IE MK Q +L + +++ H K+S EE
Sbjct: 105 --------------------TSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEE-- 142
Query: 332 RKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQK-TLIEMYKTQV 390
+E K+K L ++ + +++ +L++ Q + Q T +E +
Sbjct: 143 -------------EMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMK 189
Query: 391 QKLQEAAEIVKSRCENLLHKN-----NQITKTKNKNVEKMRGQMESHLKELERVCD---- 441
Q+LQE E + + L Q+ + K+ E E L +L D
Sbjct: 190 QQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETE 249
Query: 442 ---SLTAAERRLHECQESLQCCKGKCAD---QEHTIRELQGQVDGNHNLLTKLSLEEENC 495
L +R+L E +ESL + + D QE T E + Q+ L ++ E
Sbjct: 250 MQQKLRVLQRKLEEHEESL-VGRAQVVDLLQQELTAAEQRNQILSQQ--LQQMEAEHNTL 306
Query: 496 LIQLKCENLQQK--LEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAA 553
++ E + K LE+M+ E E + N +E + H +F E++ + A +A
Sbjct: 307 RNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQF-EQAGQAQAELESRYSA 365
Query: 554 LEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKE 613
LE QK E+E+ +S +LQ +L++ ++ ++L+ N +A +++
Sbjct: 366 LE---QKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQ 422
Query: 614 VQNSLEKSENQNESIKNYL 632
+++ L++ + N L
Sbjct: 423 LEDQLQQKSKEISQFLNRL 441
Score = 57.0 bits (136), Expect = 5e-08
Identities = 140/694 (20%), Positives = 272/694 (39%), Gaps = 131/694 (18%)
Query: 42 DILNEK---TELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSALNLKISE---Q 95
DI N K +LE L+ + +T + + + + I I+ + A+ + I+E Q
Sbjct: 2348 DIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKI--ISLLSGKEEAIQVAIAELRQQ 2405
Query: 96 KEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESENTNLKKKVFEKE 155
+ IKEL+ S + E+++ + + K+ D ++ L+E L + EN K ++ +
Sbjct: 2406 HDKEIKELENLLSQEEE-ENIVLEEENKKAVDK-TNQLMETLKTIKKENIQQKAQL---D 2460
Query: 156 AHIQELSCLFQSEKANTLKANRFSQS-VKVVHERLQIQIHKREAENDKLKEYVKSLETKI 214
+ ++ +S L + + + ++ E+ Q+ I + AEN+KLKE ++ L + +
Sbjct: 2461 SFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQL-IQEAAAENNKLKEEIRGLRSHM 2519
Query: 215 AKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKL 274
N ++ E I +E Q + +K + + KQ L+ ++L ++ E KL
Sbjct: 2520 DDLNSENAKLDAELIQYREDLNQ-VITIKDSQQ--KQLLEVQLQQNKELENKYAKLEEKL 2576
Query: 275 SETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHG---------KN 325
E+ A+ + + + EK +L +IE++K I L + +++ G K
Sbjct: 2577 KESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKV 2636
Query: 326 SCEEILR----------KVHSIEYENETLNLE--------NTKLKTTLAALKDEVVSVEN 367
EE+ R ++ +E E + E KLK L L + + N
Sbjct: 2637 KEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRN 2696
Query: 368 ELSELQE---------VEKKQKTLI--EMYKTQVQKLQEAAEIVKSRCENLLHKNNQITK 416
E +E VE +QK L+ + K ++Q + S + H N ++ +
Sbjct: 2697 ETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDE 2756
Query: 417 TKNK-----------------NVEK----------MRGQMESHLKELERVCDSLTAAERR 449
K K N E+ M E+ L LE++ L + + +
Sbjct: 2757 LKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQ 2816
Query: 450 LHECQESLQCCKGKCA-----------DQEHTIRELQ--------------------GQV 478
L L+ + +++H EL+ +V
Sbjct: 2817 LLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEV 2876
Query: 479 DGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEEC--------LK 530
++ L + + L +LK NLQQ+ Q++ E EL A +E +
Sbjct: 2877 QSLKKAMSSLQNDRDRLLKELK--NLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIM 2934
Query: 531 HSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKIL-DLETELRKK 589
L+ + S ++ ++E + E ++ +E M+ + Q+ L +L ELR
Sbjct: 2935 QEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSS 2994
Query: 590 NEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSEN 623
+ + L K Q+Q E S + S+N
Sbjct: 2995 SSQTQPL------KVQYQRQASPETSASPDGSQN 3022
Score = 56.6 bits (135), Expect = 7e-08
Identities = 124/609 (20%), Positives = 237/609 (38%), Gaps = 90/609 (14%)
Query: 49 ELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSALNLKISEQKEILIKELDTFKS 108
+L+ E + ++VE K +EK+ E A + E+ L+++ +
Sbjct: 295 QLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQ 354
Query: 109 VKLALEH---LLRKRDYKQTGDNLSSMLLENLTDNESENT-------NLKKKVFEKEAHI 158
+ LE L ++ + + S +L T E ++ N K + E +
Sbjct: 355 AQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAV 414
Query: 159 QELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAEN---DKLKEYVKSL-ETKI 214
Q + Q E K+ SQ + RL +Q H+ ++ D E +++ E I
Sbjct: 415 QSAQTIQQLEDQLQQKSKEISQFLN----RLPLQQHETASQTSFPDVYNEGTQAVTEENI 470
Query: 215 AKWNLQSRM----NKNEAIVMK--EASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIR 268
A +LQ R+ N+ A+++ E K K +S++ + TG ++ S+I
Sbjct: 471 A--SLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEIS 528
Query: 269 DQEAKLSETISASNAWKSHYEKIVIEK-TELEVQIETMKKQIINLLEDLKKMEDHGKNSC 327
+ + SA + + E +K EL V + MK+ + K++ GK +
Sbjct: 529 IVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIA--FLKLQLQGKRAE 586
Query: 328 E---EILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIE 384
E E+L + + E E + K+K L + + NE S L VEK+Q +
Sbjct: 587 EADHEVLDQKEMKQMEGE--GIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEH 644
Query: 385 MYKTQVQ-KLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSL 443
+T + L +A +KS ++ +K++ + + H ELER+ +
Sbjct: 645 QSRTSEEISLNDAGVELKSTKQD-----------GDKSLSAVPDIGQCHQDELERLKSQI 693
Query: 444 TAAERRLHECQE----SLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQL 499
E H+ QE +L + ++ I E + D N + T LS E + L Q+
Sbjct: 694 LELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQV 753
Query: 500 KCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQ 559
K ++ +L A +QLE L E +
Sbjct: 754 KELSMVTELR-----------------------------------AQVKQLEMNLAEAER 778
Query: 560 KVAEEIEKMSSRESALQIKILDLETELRKKNEE----QNQLVCKMNSKAQHQEVCLKEVQ 615
+ + E ++ ++ L +I L E + K+ + QN+L + + Q ++ +Q
Sbjct: 779 QRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNEL-DDVQLQFSEQSTLIRSLQ 837
Query: 616 NSLEKSENQ 624
+ L+ E++
Sbjct: 838 SQLQNKESE 846
Score = 43.9 bits (102), Expect = 5e-04
Identities = 96/572 (16%), Positives = 228/572 (39%), Gaps = 73/572 (12%)
Query: 33 ESHLSCLKQDILNEKTELEATLK-EAELVTHSVELL---LPLFKDTIEKINFENANLSAL 88
E L C++++ + E+E LK E + + H ++ ++ + ++ + +
Sbjct: 2659 EEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQK 2718
Query: 89 NLKISEQKEILIKELDTF----KSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESEN 144
L ++++ + L ++ +F S++ + +H + D + + S L L + N
Sbjct: 2719 LLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLN 2778
Query: 145 TNLKKKVFEKEAHIQELSCLFQSEKANTLK-ANRFSQSVKVVHERLQIQIHKREAENDKL 203
E++A + E + S + N+L + +Q + E+L + E +++
Sbjct: 2779 R-------ERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQV 2831
Query: 204 KEYVKSLET----KIAKWNLQSRMNKNEAIVMKEASRQKTV-----ALKKASKVYKQRLD 254
+ + K++ + + WN + K+E + A++ T +LKKA + D
Sbjct: 2832 QSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRD 2891
Query: 255 HFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLE 314
++ L + Q ++++ I+ + K+ ++ + ++ E ++++ ++
Sbjct: 2892 RLLKELKNL----QQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQH 2947
Query: 315 DLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTT-LAALKD---EVVSVENELS 370
+L H + E + + ++K L A+ D ++ ++N +
Sbjct: 2948 EL------------------HQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIR 2989
Query: 371 ELQEVEKKQKTLIEMYKTQV-----------QKLQEAAEIVKSRCENLLHKNNQITKTKN 419
EL+ + + L Y+ Q Q L E+++++ + L + +Q K
Sbjct: 2990 ELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQ----KE 3045
Query: 420 KNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVD 479
++++ L+E + L + L E Q+ CA E ++ELQ
Sbjct: 3046 LRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQA--- 3102
Query: 480 GNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEK 539
G N+ +E + K + ++L + E +++L N + + +E+
Sbjct: 3103 GPLNIDVAPGAPQEKNGVHRKSD--PEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEE 3160
Query: 540 SAEYTALARQLEAALEEGRQKVAEEIEKMSSR 571
+ A L A E+ R+ E E SSR
Sbjct: 3161 RDQRVAAENALSVAEEQIRR--LEHSEWDSSR 3190
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 97.1 bits (240), Expect = 5e-20
Identities = 146/653 (22%), Positives = 289/653 (44%), Gaps = 109/653 (16%)
Query: 2 EKAVNDGSHSEELF---CHLKTISEKEDLPRCTSESHLSCLKQDI----------LNEKT 48
+K +N+G++ E CH +K S H L++++ +KT
Sbjct: 87 KKKINNGTNPETTTSGGCHSPEDEQK------ASHQHQEALRRELEAQVHTIRILTCQKT 140
Query: 49 ELEATLKEAELVTHSVELLLPLFKDTIEKIN----FENANLSALNLKISEQKEILIKELD 104
EL+ L ++ H+V+ L +D I +++ F AL+ ++ QK K+ D
Sbjct: 141 ELQMALYYSQ---HAVKQLEGEARDLISRLHDSWKFAGELEQALSA-VATQK----KKAD 192
Query: 105 TFKSVKLALEHLLRKRDYKQTGDNLSSMLLEN-LTDNESENTNLKKKVFEKEAHIQELSC 163
+ +E L ++RD LS L N +TD E + EK A +QE
Sbjct: 193 RY------IEELTKERDA------LSLELYRNTITDEELK---------EKNAKLQEKLQ 231
Query: 164 LFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRM 223
L +SEK+ ++ N K+ +L + + +AE D L + ++S+ K LQ+++
Sbjct: 232 LVESEKSE-IQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK-----LQAQV 285
Query: 224 NKNEAIV-MKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKL---SETIS 279
+NE + + +K ++ + +++++ I + +IR+QE K+ E +
Sbjct: 286 EENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMW 345
Query: 280 ASNAWKSHYEKIVIEKTELEVQIETM---KKQIINLLEDL-----KKMEDHGKNSCEEIL 331
E+++ EK E ++E M K++ I LE+ K E K EE +
Sbjct: 346 EKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI 405
Query: 332 RKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEK-----KQKTLIEMY 386
R+ + + + + K++ ++++ + + ++ E EK K++ EM+
Sbjct: 406 REQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMW 465
Query: 387 KTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAA 446
+ Q +K++E EI + K K EK+R Q E ++ E++ D
Sbjct: 466 R-QEEKIREQEEIWRQ-------------KEKMHEQEKIRKQEEKVWRQEEKMHDQ---- 507
Query: 447 ERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQ 506
E ++ E +E + + K +QE IRE + ++ ++ + +EE Q + Q+
Sbjct: 508 EEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQE---QEEKMGEQEEKMQEQE 564
Query: 507 KLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIE 566
K+ + + + +E E+K+ Q+E ++ +EK E R+ E ++E +K+ E+ E
Sbjct: 565 KMRRQEEKIREQEEKIREQKEKIREQ----EEKIWEQEEKIREQEEMMQEQEEKMWEQEE 620
Query: 567 KMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLE 619
KM +E +Q E +K Q + + + + + QE ++E Q LE
Sbjct: 621 KMCEQEEKMQ--------EQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 665
Score = 78.6 bits (192), Expect = 2e-14
Identities = 109/514 (21%), Positives = 226/514 (43%), Gaps = 59/514 (11%)
Query: 58 ELVTHSVELLLPLFKDTI--EKINFENANLSA-LNLKISEQKEILIKELDTFKSVKLALE 114
EL L L L+++TI E++ +NA L L L SE+ EI + K +K LE
Sbjct: 197 ELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLN----VKELKRKLE 252
Query: 115 H---LLRKRDYKQTGDNLSSMLLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKAN 171
LL ++ + D+L L +S + L+ +V E E + L Q ++
Sbjct: 253 RAKLLLPQQQLQAEADHLGKEL-------QSVSAKLQAQVEENELWNR----LNQQQEE- 300
Query: 172 TLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAK-WNLQSRMNKNEAIV 230
K R + ++ E++Q Q K + +K++E + + + W + +M + E ++
Sbjct: 301 --KMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMM 358
Query: 231 MKEASRQKTVALKKASKVYKQR-LDHFTGAIEKLTSQ---------IRDQEAKLSETISA 280
++ + + + K K R L+ EK+ Q IR+QE + +
Sbjct: 359 WEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQE--- 415
Query: 281 SNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYE 340
+ W+ EKI ++ ++ Q + M +Q + E K E+ + EE+ R+ I +
Sbjct: 416 AKMWRQE-EKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQ 474
Query: 341 NETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIV 400
E + + ++E V + E ++ + E+K + E Q +K++E E +
Sbjct: 475 EEIWRQKEKMHEQEKIRKQEEKVWRQEE--KMHDQEEKIREQEEKMWRQEEKIREQEEKI 532
Query: 401 KSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCC 460
+ + E + + + + + K G+ E ++E E+ + E ++ E +E ++
Sbjct: 533 REQEEKIREQEEMMQEQEEK-----MGEQEEKMQEQEK----MRRQEEKIREQEEKIREQ 583
Query: 461 KGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEK 520
K K +QE I E + ++ ++ + +EE Q ++K+ + + + +E E+
Sbjct: 584 KEKIREQEEKIWEQEEKIREQEEMMQE---QEEKMWEQ------EEKMCEQEEKMQEQEE 634
Query: 521 KLANQEECLKHSNLKFKEKSAEYTALARQLEAAL 554
K+ QEE + ++ +++ + LEAA+
Sbjct: 635 KMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 668
Score = 69.7 bits (169), Expect = 8e-12
Identities = 88/413 (21%), Positives = 181/413 (43%), Gaps = 45/413 (10%)
Query: 227 EAIVMKEASRQKTVALKKASKVYKQRLDHFTG-AIEKLTSQIRDQEAKLSETISASNAWK 285
EA+ + ++ T+ + K Q +++ A+++L + RD ++L ++ WK
Sbjct: 119 EALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDS------WK 172
Query: 286 SHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLN 345
E + + T KK+ +E+L K D S+E T+
Sbjct: 173 -----FAGELEQALSAVATQKKKADRYIEELTKERD------------ALSLELYRNTIT 215
Query: 346 LENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQV--QKLQEAAEIVKSR 403
E K K A L++++ VE+E SE+Q K+ K +E K + Q+LQ A+ +
Sbjct: 216 DEELKEKN--AKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKE 273
Query: 404 CENLLHK------NNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESL 457
+++ K N++ N+ E+ + E ++E E + + E ++ E +E +
Sbjct: 274 LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWE---EKIQEQEEKIREQEEKI 330
Query: 458 QCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKE 517
+ + K QE + E + ++ ++ + EE+ ++ ++K+ +++ + E
Sbjct: 331 REQEEKMRRQEEMMWEKEEKMRRQEEMMWEK--EEKMRRLEEMMWEKEEKIRELEEKMHE 388
Query: 518 LEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQI 577
EK +E+ + ++ +EK E A + E + E +K+ E+ +KM +E +
Sbjct: 389 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHE 448
Query: 578 KILDLETELRKKNEEQNQLVCKMNSKAQHQEVC--LKEVQNSLEKSENQNESI 628
+ E E R++ EE + + K + QE KE + EK Q E +
Sbjct: 449 QEKIREEEKRQEQEE----MWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKV 497
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 96.7 bits (239), Expect = 6e-20
Identities = 138/644 (21%), Positives = 283/644 (43%), Gaps = 68/644 (10%)
Query: 19 KTISEKEDLPRCTSESHLSCLKQDILNEKTE--------LEATLKEAELVTHSVELLLPL 70
KT E ++L E +C K +I NEK + L+ L++ EL EL+L
Sbjct: 870 KTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELIL-- 927
Query: 71 FKDTIEKI-NFENANLSALNLKISEQKEILIKEL----DTFKSVKLALEHLLRKRDYKQT 125
KD++ K + +N LS++ ++ E+ E L KE + +KL ++ D +
Sbjct: 928 LKDSLAKSPSVKNDPLSSVK-ELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRK 986
Query: 126 GDNLSSMLLENLTDNESENTNLKKKVFEKEAHIQELSCLF--QSEKANTLK--ANRFSQS 181
LE+L + + + + + + + L + QSE+ + K AN F
Sbjct: 987 ETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHR 1046
Query: 182 VKVVHERLQ---IQIHKREAENDKLKEYVKSLETKIAKWNLQS-RMNKNEAIVMKEASRQ 237
++ + +L+ +Q ++N+ L +++L++ +Q + + +A+V KE +
Sbjct: 1047 IEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAE 1106
Query: 238 KTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTE 297
K L+K K+ + +E+L Q++ ++ +L +T+ K ++ + E
Sbjct: 1107 K---LQKEQKIKEHATT--VNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNME 1161
Query: 298 LEVQIETMKKQII-------NLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTK 350
+ E + K++ N +EDL++ K E + ++ S++ + +NTK
Sbjct: 1162 I-ADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTK 1220
Query: 351 LKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHK 410
+K L V + EL++ ++ E L K +++ Q+ E+ K +
Sbjct: 1221 IKQLL-------VKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLA----- 1268
Query: 411 NNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHT 470
+IT K+K E ++ E H + +L+A ++R+ QE C+ A+Q
Sbjct: 1269 --EITSEKHKIHEHLKTSAEQHQR-------TLSAYQQRVTALQEE---CRAAKAEQATV 1316
Query: 471 IRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLK 530
E + HN+L + ++ + Q + E +Q+ E ++ +L+ KL + + L+
Sbjct: 1317 TSEFESYKVRVHNVLKQ---QKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQ 1373
Query: 531 HSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESA-LQIKILDLET--ELR 587
+ + + +E+ L + L+E K AE EK+ S +S + +K +T +L
Sbjct: 1374 INVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLT 1433
Query: 588 KKNEE-QNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKN 630
+NE +N ++ + ++ +Q L K E Q +KN
Sbjct: 1434 SQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKN 1477
Score = 74.7 bits (182), Expect = 2e-13
Identities = 129/662 (19%), Positives = 264/662 (39%), Gaps = 84/662 (12%)
Query: 33 ESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSALNLKI 92
E ++ +K + K EL+++ KE + V K+ +E + E LSA
Sbjct: 964 EEKINKIKLVAVKAKKELDSSRKETQTV-----------KEELESLRSEKDQLSA----- 1007
Query: 93 SEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLT-------------D 139
LI+ +++K++ L E + D ++ N +E+LT +
Sbjct: 1008 --SMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETIN 1065
Query: 140 NESENTNLKKKVFEKEAHIQELSCL-FQSEKA---NTLKANRFSQSVKVVH--------E 187
+++E+ + + + A + E+ L Q KA L+A + + K+ E
Sbjct: 1066 SDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELE 1125
Query: 188 RLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQ------KTVA 241
LQ+Q+ K + + K + ++ ++ + L + + +MKE +++ K
Sbjct: 1126 ELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIED 1185
Query: 242 LKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLS-----------ETISASNAWKSHYEK 290
L++ K+ KQ+ + I L S ++ E K + E + A H
Sbjct: 1186 LEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLIL 1245
Query: 291 IVIEKTELEV---QIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLE 347
K ELE Q+E K Q+ + + K+ +H K S E+ R + + + L E
Sbjct: 1246 QASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEE 1305
Query: 348 NTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENL 407
K A + E S + + + + ++K K++ + ++ +E E++ + +
Sbjct: 1306 CRAAKAEQATVTSEFESYKVRVHNVLK-QQKNKSMSQAETEGAKQEREHLEMLIDQLKIK 1364
Query: 408 LHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQ 467
L + + ++ ++ + ++ L+ ++ + E L E S+Q +
Sbjct: 1365 LQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQS-ENMMMKS 1423
Query: 468 EHT--IRELQGQVDGNHNLLTKL--SLEEENCLIQLKCENLQQKLEQMDAENKELEKKLA 523
EHT + +L Q + N L+EE+ + E LQQ+L +M+A+ +L+ +
Sbjct: 1424 EHTQTVSQLTSQNEVLRNSFRDQVRHLQEEH---RKTVETLQQQLSKMEAQLFQLKNEPT 1480
Query: 524 NQEECLKHSNLK-FKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSR-------ESAL 575
+ +LK +E+ L EEG + E +SS E L
Sbjct: 1481 TRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLL 1540
Query: 576 QIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFL 635
LE L + +LV K++S + + + L ++E N + ++ L
Sbjct: 1541 NSPETKLEPPLWHAEFTKEELVQKLSSTTKSAD----HLNGLLRETEATNAILMEQIKLL 1596
Query: 636 KT 637
K+
Sbjct: 1597 KS 1598
Score = 73.6 bits (179), Expect = 5e-13
Identities = 148/679 (21%), Positives = 275/679 (40%), Gaps = 109/679 (16%)
Query: 18 LKTISEKED---LPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDT 74
+K ++E+ D L + +E LK++ + K E+E ++ + +E +
Sbjct: 71 IKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKE 130
Query: 75 IEKINFENANLSALNLKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLL 134
IE + E L A+ K SE K L K+L+ + +L L L+ ++ +
Sbjct: 131 IENLKNE---LMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSE---------- 177
Query: 135 ENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIH 194
+N+ + E ++ E+ ++Q+ EK T+ + ++ + Q I+
Sbjct: 178 DNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETV--TQLQNIIEANSQHYQKNIN 235
Query: 195 KREAENDKLK----EYVKSLETKIAKWNLQSRMNKNEAIVMKE-ASRQKTVALKKASKVY 249
+ E +LK E VK L +I + N+ +KE +Q + K K Y
Sbjct: 236 SLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKY 295
Query: 250 KQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKT--------ELEVQ 301
+ L++ + K TS +Q+ ++ + N + E++V EK ELE Q
Sbjct: 296 ECELEN----LRKATSNA-NQDNQICSILLQENTF---VEQVVNEKVKHLEDTLKELESQ 347
Query: 302 IETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDE 361
+K ++ + K+E ++ +E + +E+ K+ L A +++
Sbjct: 348 HSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEF----------KINELLLAKEEQ 397
Query: 362 VVSVENELSELQEVEKKQKTLIEMYKTQVQKLQE-------------------------- 395
+E SEL + K+ +E + +VQ L+E
Sbjct: 398 GCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMF 457
Query: 396 AAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKEL----ERVCDSLTAAERR-- 449
+ +K +CENL + + N E +R ME EL ++ + +++
Sbjct: 458 EIQGLKEQCENLQQEKQEAI----LNYESLREIMEILQTELGESAGKISQEFESMKQQQA 513
Query: 450 --LHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQK 507
+HE Q+ L+ + T+ LQG+ N LL++ L E ++ +NLQ+K
Sbjct: 514 SDVHELQQKLRTAFTEKDALLETVNRLQGE---NEKLLSQQELVPE---LENTIKNLQEK 567
Query: 508 -------LEQMDAENKELEKKLANQEECLKHSNLKFKEKSAE----YTALARQLEAALEE 556
L Q D KELE K+ + E K K E + R+ LE
Sbjct: 568 NGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILEL 627
Query: 557 GRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQ---NQLVCKMNSKAQHQEVCLKE 613
G+ KV + I+ S E + LE L++K++ +L+ +M ++ +EV E
Sbjct: 628 GK-KVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAE 686
Query: 614 VQNSLEKSENQNESIKNYL 632
V+ SL + N+ S K L
Sbjct: 687 VK-SLYEENNKLSSEKKQL 704
Score = 67.4 bits (163), Expect = 4e-11
Identities = 144/713 (20%), Positives = 275/713 (38%), Gaps = 139/713 (19%)
Query: 39 LKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKIN------FENANLSALNLKI 92
+K + +E+ +LE + E L ++ K + +N E N +LK
Sbjct: 372 IKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKE 431
Query: 93 SEQKEIL-IKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESENTN---LK 148
QKEI + E S K L + + K+ +NL E + + ES L+
Sbjct: 432 QHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQ 491
Query: 149 KKVFEKEAHI-QELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKL---K 204
++ E I QE + Q + ++ + + ++ + L +++ + EN+KL +
Sbjct: 492 TELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQ 551
Query: 205 EYVKSLETKIAKWNLQSR-------MNKNEAIVMKEASRQKTVALKKASKVYK-----QR 252
E V LE I NLQ + +++ + ++ + + ++ +K + K +
Sbjct: 552 ELVPELENTIK--NLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEE 609
Query: 253 LDHFTGAIEK---------------------LTSQIRDQEAKLSETISASNAWKSHYEKI 291
+D+F E+ L ++ + L ET+ + EK+
Sbjct: 610 MDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKL 669
Query: 292 VIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKL 351
+++ L E + ++ +L E+ K+ K ++ +V + E+ L T+L
Sbjct: 670 MVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDL--EVFLSQKEDVILKEHITQL 727
Query: 352 KTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQK-LQEAAEIVKSRCE----- 405
+ L + +E ++ L++L E E+ QK + KTQ+ L+E V E
Sbjct: 728 EKKLQLMVEE----QDNLNKLLENEQVQKLFV---KTQLYGFLKEMGSEVSEDSEEKDVV 780
Query: 406 NLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCA 465
N+L + N+ + Q + + ELE+ L E + +C+E K
Sbjct: 781 NVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCL--QEESVVQCEE----LKSLLR 834
Query: 466 DQEH-------TIRELQGQVDG-------NHNLLTKLSLEEENCLIQL------------ 499
D E + E+Q + + N K LE +N LIQ+
Sbjct: 835 DYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEI 894
Query: 500 -----KC-----ENLQQKLEQMDAEN--------------------------KELEKKLA 523
KC ENL+ LEQ + + KELE+K+
Sbjct: 895 HNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIE 954
Query: 524 NQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDL- 582
N E+ K K + ++L+++ +E Q V EE+E + S + L + DL
Sbjct: 955 NLEKECKEKEEKINKIKLVAVKAKKELDSSRKE-TQTVKEELESLRSEKDQLSASMRDLI 1013
Query: 583 -----ETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKN 630
L + E+Q++ + +A + E ++++ L S Q E+I +
Sbjct: 1014 QGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINS 1066
Score = 41.6 bits (96), Expect = 0.002
Identities = 42/182 (23%), Positives = 77/182 (42%), Gaps = 25/182 (13%)
Query: 457 LQCCKGKCADQEHTIRELQGQ--VDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAE 514
+Q K +C + E I EL+ + +G +++ L+ E + L+ K E QQ L
Sbjct: 41 IQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALT-ERLDALLLEKAETEQQCLS----- 94
Query: 515 NKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESA 574
LK N+K K++ + LE+ +EIE + + A
Sbjct: 95 --------------LKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMA 140
Query: 575 LQIKILDLETELRKKNEEQNQLVCKMNSKAQHQ---EVCLKEVQNSLEKSENQNESIKNY 631
++ K + + L+K+ EE +++ + + Q E +K++Q +EK E Y
Sbjct: 141 VRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILY 200
Query: 632 LQ 633
LQ
Sbjct: 201 LQ 202
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 96.7 bits (239), Expect = 6e-20
Identities = 156/742 (21%), Positives = 316/742 (42%), Gaps = 126/742 (16%)
Query: 12 EELFCHLKTISEKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHS-VEL---- 66
+EL ++ + E+ + R T + + D E EL L+EA VT + +EL
Sbjct: 1110 KELQARIEELEEEIEAERAT-RAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKR 1168
Query: 67 ---LLPLFKDTIEKINFENANLSALNLKISEQKEILIKELDTFKSVKLALEHLLRKRDYK 123
L L +D E A ++AL K ++ L +++D + VK LE K ++K
Sbjct: 1169 EAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEK--EKSEFK 1226
Query: 124 QTGDNLSSM-----------------LLENLTDNESENTNLKKKVFE---KEAHIQ---- 159
D+LSS L + L++ +N +++ + E +++ +Q
Sbjct: 1227 LEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAG 1286
Query: 160 ELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSL--------- 210
ELS + +++ + +R Q+ E L+ Q+ + + L ++S
Sbjct: 1287 ELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLRE 1346
Query: 211 ---ETKIAKWNLQSRMNKNEAIVMKEASR------QKTVALKKASKVYKQRLDHFT---- 257
E + K LQ ++K + V + ++ Q+T L++A K QRL
Sbjct: 1347 QYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVE 1406
Query: 258 ------GAIEKLTSQIRDQEAKLSETISASNAWKS-------HYEKIVIE-KTELE---V 300
++EK +++ + L + +N+ + +++K++ E KT+ E
Sbjct: 1407 AVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQA 1466
Query: 301 QIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAA--- 357
++E K+ +L +L K+ KN+ EE L ++ +++ EN+ L E L +A
Sbjct: 1467 ELEASLKESRSLSTELFKL----KNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGK 1522
Query: 358 ----LKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNN- 412
L+ +E E +++Q ++ + +E + ++ ++Q VKS + + + +
Sbjct: 1523 TIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDE 1582
Query: 413 ---QITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEH 469
Q+ + + VE M+ +++ ++ E L+E + L + A+
Sbjct: 1583 EIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLK 1642
Query: 470 TIRELQGQVD-----------GNHNLLTKLSLEEENC-LIQLKCENLQQKLEQMDAENKE 517
+R +QGQ+ G +L +L++ E L+Q + E L+ LEQ + K
Sbjct: 1643 HLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKL 1702
Query: 518 LEKKLANQEE----------CLKHSNLKFK----EKSAEYTALARQLEAALEEGRQKV-- 561
E++L + E L H+ K + + +E +R A E+ ++ +
Sbjct: 1703 AEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITD 1762
Query: 562 ----AEEIEKMSSRESALQIKILDLE---TELRKKNEEQNQLVCKMNSK-AQHQEVCLKE 613
AEE++K + L+ +LE +L+ + +E QL K K Q E ++E
Sbjct: 1763 AAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRE 1822
Query: 614 VQNSLEKSENQN-ESIKNYLQF 634
++ LE + +N ES+K ++
Sbjct: 1823 LEFELEGEQKKNTESVKGLRKY 1844
Score = 91.7 bits (226), Expect = 2e-18
Identities = 142/649 (21%), Positives = 275/649 (42%), Gaps = 106/649 (16%)
Query: 27 LPRCTSESHLSCLK-QDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANL 85
L + E H + K +++ E + L+ T+ + +T + L + ++ + E +
Sbjct: 962 LAKVEKEKHATENKVKNLTEELSGLDETIAK---LTREKKALQEAHQQALDDLQAEEDKV 1018
Query: 86 SALNL---KISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNES 142
++LN K+ +Q E L L+ K +++ LE RK + GD + E++ D E+
Sbjct: 1019 NSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLE----GD--LKLAQESILDLEN 1072
Query: 143 ENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDK 202
+ L +++ +K+ +L + E+ L+ + + ++ E L+ +I A K
Sbjct: 1073 DKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAK 1132
Query: 203 LK----EYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQR--LDHF 256
+ +Y + LE L R+ + + + K K+ ++ K R L+
Sbjct: 1133 TEKQRSDYARELE------ELSERLEEAGGVTSTQIELNK----KREAEFLKLRRDLEEA 1182
Query: 257 TGAIEKLTSQIR----DQEAKLSETISASNAWKSHYEKIVIEKTELEVQI-------ETM 305
T E + + +R D A+L E I K EK EK+E +++I E++
Sbjct: 1183 TLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEK---EKSEFKLEIDDLSSSMESV 1239
Query: 306 KKQIINLLEDLKKMEDH-----GKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKD 360
K NL + + +ED GKN EEI R + + + L E +L L +
Sbjct: 1240 SKSKANLEKICRTLEDQLSEARGKN--EEIQRSLSELTTQKSRLQTEAGELSRQL----E 1293
Query: 361 EVVSVENELSE-----LQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQIT 415
E S+ ++LS Q+ E+ ++ L E K + L A + + C+ L + +
Sbjct: 1294 EKESIVSQLSRSKQAFTQQTEELKRQLEEENKAK-NALAHALQSSRHDCDLLREQYEEEQ 1352
Query: 416 KTK----------NKNVEKMRGQMESH-LKELERVCDSLTAAERRLHECQESLQCCKGKC 464
+ K N V + R + E+ ++ E + ++ +RL + +E ++ KC
Sbjct: 1353 EGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKC 1412
Query: 465 ADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLAN 524
A E T + LQG+V E+L +E+ ++ L+KK N
Sbjct: 1413 ASLEKTKQRLQGEV-----------------------EDLMVDVERANSLAAALDKKQRN 1449
Query: 525 QEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLET 584
++ L K +E AE LEA+L+E R E + ++ E AL LET
Sbjct: 1450 FDKVLAEWKTKCEESQAE-------LEASLKESRSLSTELFKLKNAYEEALD----QLET 1498
Query: 585 ELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQ 633
++++N+ Q + + + + E++ S ++ E + I+ L+
Sbjct: 1499 -VKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALE 1546
Score = 72.0 bits (175), Expect = 2e-12
Identities = 96/471 (20%), Positives = 196/471 (41%), Gaps = 65/471 (13%)
Query: 202 KLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIE 261
K+K +KS ET+ ++ K + + K +++K + K + V Q + ++
Sbjct: 836 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLV--QEKNDLQLQVQ 893
Query: 262 KLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMED 321
+ + D E + + I A + Q+E K++ ED +++
Sbjct: 894 AESENLLDAEERCDQLIKA------------------KFQLEAKIKEVTERAEDEEEIN- 934
Query: 322 HGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKT 381
E+ K +E E L + L+ TLA ++ E + EN++ L E
Sbjct: 935 ------AELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDE 988
Query: 382 LIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNK---NVEKMRGQMESHLK---E 435
I + + LQEA + + K N + KTK+K VE + +E K +
Sbjct: 989 TIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVD 1048
Query: 436 LER----VCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLE 491
LER + L A+ + + + Q + ++ +LQ +V+ L L +
Sbjct: 1049 LERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTL--GLQFQ 1106
Query: 492 EENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKF--------------K 537
++ +Q + E L++++E A + EK+ ++ L+ + + K
Sbjct: 1107 KKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNK 1166
Query: 538 EKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLV 597
++ AE+ L R LE A + VA +K + + L +I +L+ +K +E+++
Sbjct: 1167 KREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK 1226
Query: 598 CKMN-----------SKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKT 637
+++ SKA +++C + +++ L ++ +NE I+ L L T
Sbjct: 1227 LEIDDLSSSMESVSKSKANLEKIC-RTLEDQLSEARGKNEEIQRSLSELTT 1276
Score = 56.2 bits (134), Expect = 9e-08
Identities = 89/445 (20%), Positives = 183/445 (41%), Gaps = 55/445 (12%)
Query: 2 EKAVNDGSHSEELFCHLKTIS-EKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAEL- 59
E+ +G EL K I EK D+ E+ + ++ + +LE T ++E+
Sbjct: 1515 EQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEID 1574
Query: 60 -----VTHSVELLLPLFKDTIEKINFENANLSALNLKISEQKEI--LIKELD-TFKSVKL 111
+E L ++ T+E + SAL+ ++ + E L K+++ +++
Sbjct: 1575 RKIAEKDEEIEQLKRNYQRTVETMQ------SALDAEVRSRNEAIRLKKKMEGDLNEIEI 1628
Query: 112 ALEHLLRKRDYKQTGDNLSSM-------------LLENLTDNESENTNLKKKVFEKEAHI 158
L H R +T +L S+ L D + + ++++ +A +
Sbjct: 1629 QLSHA--NRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEV 1686
Query: 159 QEL-SCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAKW 217
+EL + L Q+E+A L S +ER+Q+ +H +N L K LET + +
Sbjct: 1687 EELRATLEQTERARKLAEQELLDS----NERVQL-LH---TQNTSLIHTKKKLETDLMQL 1738
Query: 218 NLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLD---HFTGAIEKLTSQIRDQEAKL 274
+ +A +E +++ ++ K+ D H + L ++D + +L
Sbjct: 1739 QSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRL 1798
Query: 275 SETIS-ASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRK 333
E A K +K+ ELE ++E +K+ ++ L+K E R+
Sbjct: 1799 DEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYE-----------RR 1847
Query: 334 VHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKL 393
V + Y++E +L+ + L+ +V S + + E E T + ++++
Sbjct: 1848 VKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEA 1907
Query: 394 QEAAEIVKSRCENLLHKNNQITKTK 418
+E A+I +S+ L K T ++
Sbjct: 1908 EERADIAESQVNKLRAKTRDFTSSR 1932
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 96.3 bits (238), Expect = 8e-20
Identities = 135/663 (20%), Positives = 291/663 (43%), Gaps = 108/663 (16%)
Query: 23 EKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFEN 82
EK+D E +S L+QDI+ ++ LE S++ LL K ++K N +
Sbjct: 778 EKKDQQFKEQEKTMSMLQQDIICKQHHLE-----------SLDRLLTESKGEMKKENMKK 826
Query: 83 AN-LSALNLKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNE 141
L AL ++SE+ I +++LD+ ++++ E L+ + L L N+
Sbjct: 827 DEALKALQNQVSEET-IKVRQLDS--ALEICKEELV--------------LHLNQLEGNK 869
Query: 142 SE-NTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQ---IHKRE 197
+ LKKK +E+ CL + K S+ ++ LQ Q + +
Sbjct: 870 EKFEKQLKKKS-------EEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQET 922
Query: 198 AENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFT 257
N +L++ LE +++K + + + + +K + + + +Q++ T
Sbjct: 923 IRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELT 982
Query: 258 GAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQI---INLLE 314
G ++ ++ + +LS+ K E + ++L++ ++ K ++ N ++
Sbjct: 983 GTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVK 1042
Query: 315 DLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKD-------EVVSVEN 367
+L+K++ + E L+K +E E + + E LK+TL L++ +S+E
Sbjct: 1043 ELEKLQHSTETELTEALQKREVLETELQNAHGE---LKSTLRQLQELRDVLQKAQLSLEE 1099
Query: 368 ELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRG 427
+ + ++++ + + + + Q+L E + +K R L + Q+T + + + RG
Sbjct: 1100 KYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHL-DMTIREHRG 1158
Query: 428 QMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTK 487
+ME + +LE +L +E L EC + ++ K + + +RE +
Sbjct: 1159 EMEQKIIKLE---GTLEKSELELKECNKQIESLNDKLQNAKEQLREKE---------FIM 1206
Query: 488 LSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQ--------------EECLKHSN 533
L E+E ++ + E QQ++++M++ KE E+ +A Q E +++S+
Sbjct: 1207 LQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSH 1266
Query: 534 LKFKEKSAEYTALARQLE---AALEEGRQ----------KVAEEIEKMSSRESAL----- 575
+ E + R++E + LE+ +Q +AEE+ RE+ L
Sbjct: 1267 TELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQ 1326
Query: 576 -QIKILDLETELRKK-------NEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNES 627
+IK L E E K+ + ++N K+++ +Q V +++ LEK++ + E
Sbjct: 1327 AEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSV--QQLNEQLEKAKLELEE 1384
Query: 628 IKN 630
++
Sbjct: 1385 AQD 1387
Score = 86.3 bits (212), Expect = 8e-17
Identities = 135/638 (21%), Positives = 271/638 (42%), Gaps = 82/638 (12%)
Query: 36 LSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFEN-ANLSALNLKISE 94
L +Q+I + + EL + K + EL FK + K + +N + E
Sbjct: 496 LDLCQQEIESSRVELRSLEKIISQLPLKRELFG--FKSYLSKYQMSSFSNKEDRCIGCCE 553
Query: 95 QKEILIKELDTFKSVKLALEHL-LRKRDYKQTGDNLSSMLLE-NLTDNESENTNLKKKVF 152
+++I EL +KLA++ ++K T + LS L+ N + S+ ++L+ +
Sbjct: 554 ANKLVISEL----RIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPV 609
Query: 153 EKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYV----- 207
+ H S Q++ + + Q + E L+ ++ + EAEN LK +
Sbjct: 610 KLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTS 669
Query: 208 -------KSLETKIAKWNLQSRMNK--NEAIVMKEASRQKTVA---LKKASKVYKQRLDH 255
+ LE L+S M K ++ + +++ +K VA + + +Q L
Sbjct: 670 QFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELME 729
Query: 256 FTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLED 315
I L + I + K+ ++ A K H E + E+E QIE ++ Q+ +
Sbjct: 730 KNEKIRSLETNINTEHEKIC--LAFEKAKKIHLE----QHKEMEKQIERLEAQLEKKDQQ 783
Query: 316 LKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEV 375
K+ E ++I+ K H +E + L ++K + + +++N++SE
Sbjct: 784 FKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSE---- 839
Query: 376 EKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKE 435
+T+ +V++L A EI K E +LH N ++ G E K+
Sbjct: 840 ----ETI------KVRQLDSALEICKE--ELVLHLN------------QLEGNKEKFEKQ 875
Query: 436 LERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENC 495
L++ + + ++ L SLQ + +HT+++ Q + + LE+
Sbjct: 876 LKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQML--QQETIRNGELEDTQT 933
Query: 496 LIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALE 555
++ + L+Q+L++ + E +K+ + E H ++K E T ARQ++ ++
Sbjct: 934 KLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMD 993
Query: 556 EGRQ---KVAEEIE--KMSSRESALQIKILDL-----ETELRKKNEE-------QNQLVC 598
+ ++ K+ +EI K A+ + LD+ +TEL KK Q+
Sbjct: 994 QYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTET 1053
Query: 599 KMNSKAQHQEVCLKEVQNS---LEKSENQNESIKNYLQ 633
++ Q +EV E+QN+ L+ + Q + +++ LQ
Sbjct: 1054 ELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQ 1091
Score = 62.4 bits (150), Expect = 1e-09
Identities = 109/519 (21%), Positives = 209/519 (40%), Gaps = 97/519 (18%)
Query: 152 FEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHE--RLQIQIHKREAENDKLKEYVKS 209
+E I S FQ + + + FS S V E L+ +++K +N L S
Sbjct: 199 YENVCKISGSSTDFQKKPRDKM----FSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHS 254
Query: 210 LETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRD 269
L TK + + ++ + +++ A +Q + + ++++ + + +R+
Sbjct: 255 LMTKFESIHFELTQSRAKVSMLESAQQQAA-----SVPILEEQIINLEAEVSAQDKVLRE 309
Query: 270 QEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEE 329
E KL ++ +K+VIEK E ++ K++ I L DL + GK +
Sbjct: 310 AENKLEQS-----------QKMVIEK---EQSLQESKEECIKLKVDLLEQTKQGKRA--- 352
Query: 330 ILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSE--LQEVEKKQKTLIEMYK 387
R+ + Y E L+ + K +A K E V E E+ E L EK+ K
Sbjct: 353 -ERQRNEALYNAEELSKAFQQYKKKVAE-KLEKVQAEEEILERNLTNCEKENK------- 403
Query: 388 TQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAE 447
+LQE + KS E L K Q+ + N EK+R + V +S A+
Sbjct: 404 ----RLQERCGLYKSELEILKEKLRQLKEENNNGKEKLR---------IMAVKNSEVMAQ 450
Query: 448 RRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQK 507
L E ++S+ + + +++ +R+ ++ N L +++ + E + + QQ+
Sbjct: 451 --LTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNE------RLDLCQQE 502
Query: 508 LEQMDAENKELEKKLAN----------QEECLKHSNLKFKEKSAEYTALARQLEAALEEG 557
+E E + LEK ++ + K+ F K + + E
Sbjct: 503 IESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISEL 562
Query: 558 RQKVA---EEIEKMSSRESALQI--------------KILDLETELRK----------KN 590
R K+A EI+K+ + +A Q+ K+ LETE K K+
Sbjct: 563 RIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKD 622
Query: 591 EEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIK 629
+ Q+ + + + Q ++E++ L + E +N +K
Sbjct: 623 QNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLK 661
Score = 41.6 bits (96), Expect = 0.002
Identities = 48/238 (20%), Positives = 104/238 (43%), Gaps = 32/238 (13%)
Query: 406 NLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHEC---QESLQCCKG 462
N L + N T+N ++ + L + L +A+++ +E + +
Sbjct: 239 NKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEA 298
Query: 463 KCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKL 522
+ + Q+ +RE + +++ + K+ +E+E L + K E ++ K++ ++ + K+ ++
Sbjct: 299 EVSAQDKVLREAENKLEQSQ----KMVIEKEQSLQESKEECIKLKVDLLE-QTKQGKRAE 353
Query: 523 ANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDL 582
+ E L + A +L A ++ ++KVAE++EK+ + E L+ + +
Sbjct: 354 RQRNEALYN---------------AEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNC 398
Query: 583 ETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSYV 640
E E ++ E ++ LKE L K EN N K + +K S V
Sbjct: 399 EKENKRLQERCGLYKSELE--------ILKEKLRQL-KEENNNGKEKLRIMAVKNSEV 447
>gi|4758650 kinesin family member 5C [Homo sapiens]
Length = 957
Score = 94.4 bits (233), Expect = 3e-19
Identities = 104/504 (20%), Positives = 220/504 (43%), Gaps = 70/504 (13%)
Query: 162 SCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQS 221
S L ++A T+K N S ++++ E + + K + +N LK ++ LE ++ +W
Sbjct: 316 STLMFGQRAKTIK-NTVSVNLELTAEEWKKKYEKEKEKNKTLKNVIQHLEMELNRWRNGE 374
Query: 222 RMNKNEAIVMKE-----------------------ASRQKTVALKKASKVYKQ------R 252
+ ++E I K+ ++ +K ++ S +Y+Q
Sbjct: 375 AVPEDEQISAKDQKNLEPCDNTPIIDNIAPVVAGISTEEKEKYDEEISSLYRQLDDKDDE 434
Query: 253 LDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINL 312
++ + EKL Q+ DQ+ L+ T + YEKI E T L+++ E K ++ +
Sbjct: 435 INQQSQLAEKLKQQMLDQDELLAST-------RRDYEKIQEELTRLQIENEAAKDEVKEV 487
Query: 313 LEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSEL 372
L+ L+++ + +E+ K + E + L + T L TT + ELS+L
Sbjct: 488 LQALEELAVNYDQKSQEVEDKTRANEQLTDELAQKTTTLTTT-----------QRELSQL 536
Query: 373 QEVEKKQKT-LIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMES 431
QE+ QK E+ ++ L E I+ + L N + + + +M+S
Sbjct: 537 QELSNHQKKRATEILNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEEFTMARLYISKMKS 596
Query: 432 HLKELERVCDSLTAAE----RRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTK 487
+K L L +A+ R+++ + L C+ + E I+ L + +
Sbjct: 597 EVKSLVNRSKQLESAQMDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQ 656
Query: 488 LSLEEENCLIQLKCENLQQKLEQMDAENKELE--KKLANQEECLKHSNLKFKEKSAEYTA 545
L +++ +L Q+K+ ++ ++KE E +L + EE K A
Sbjct: 657 LEESQDSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEMKK--------------A 702
Query: 546 LARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQ 605
L +Q+E+ E +++++ +++ ++ + +I DL +L+ + E+ + K+ + Q
Sbjct: 703 LEQQMESHREAHQKQLSRLRDEIEEKQKIID-EIRDLNQKLQLEQEKLSSDYNKLKIEDQ 761
Query: 606 HQEVCLKEVQNSLEKSENQNESIK 629
+E+ L+++ +K E E +K
Sbjct: 762 EREMKLEKLLLLNDKREQAREDLK 785
Score = 53.9 bits (128), Expect = 4e-07
Identities = 108/539 (20%), Positives = 214/539 (39%), Gaps = 56/539 (10%)
Query: 40 KQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSALNLKISEQKEIL 99
K D +N++++L LK+ L ELL +D EKI E L+ L ++ K
Sbjct: 431 KDDEINQQSQLAEKLKQQML--DQDELLASTRRD-YEKIQEE---LTRLQIENEAAK--- 481
Query: 100 IKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESENTNLKKKVFEKEAHIQ 159
D K V ALE L D K + E LTD ++ T + + +Q
Sbjct: 482 ----DEVKEVLQALEELAVNYDQKSQEVEDKTRANEQLTDELAQKTTTLTTTQRELSQLQ 537
Query: 160 ELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAE-NDKLKEYVKSLETKIAKWN 218
ELS +K T N + + + + K A+ N ++E I+K
Sbjct: 538 ELS--NHQKKRATEILNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEEFTMARLYISKMK 595
Query: 219 LQSRMNKNEAIVMKEA---SRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLS 275
+ + N + ++ A S +K A ++ + + I+ LT +++ E K
Sbjct: 596 SEVKSLVNRSKQLESAQMDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRR 655
Query: 276 ETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVH 335
+ + ++ K+ ++ EV + +K+ + L+D ++M+
Sbjct: 656 QLEESQDSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEMK--------------K 701
Query: 336 SIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQE 395
++E + E+ + K L+ L+DE+ + + E++++ +K + E + KL+
Sbjct: 702 ALEQQMESHREAHQK---QLSRLRDEIEEKQKIIDEIRDLNQKLQLEQEKLSSDYNKLKI 758
Query: 396 AAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERV-------CDSLTAAER 448
+ + + E LL N++ + + E ++G E+ +EL+ + LT +
Sbjct: 759 EDQEREMKLEKLLLLNDKREQAR----EDLKGLEETVSRELQTLHNLRKLFVQDLTTRVK 814
Query: 449 RLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKL--SLEEENCLIQLKCENLQQ 506
+ E G A Q+ I L + N LTK+ L +N ++ + L++
Sbjct: 815 KSVELDND---DGGGSAAQKQKISFL----ENNLEQLTKVHKQLVRDNADLRCELPKLEK 867
Query: 507 KLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEI 565
+L K LE L +E +++++ R A ++A+ I
Sbjct: 868 RLRATAERVKALESALKEAKENAMRDRKRYQQEVDRIKEAVRAKNMARRAHSAQIAKPI 926
Score = 53.9 bits (128), Expect = 4e-07
Identities = 104/458 (22%), Positives = 192/458 (41%), Gaps = 66/458 (14%)
Query: 23 EKEDLPRCTSESHLSCLKQDILNEKTELEATLKEA----ELVTH----SVELLLPLFKDT 74
E ED R + L ++ + T L T +E EL H + E+L L KD
Sbjct: 504 EVEDKTRANEQ-----LTDELAQKTTTLTTTQRELSQLQELSNHQKKRATEILNLLLKDL 558
Query: 75 IEKINFENAN----LSALNLKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLS 130
E N L+ +N I E+ + + KS +L + ++ + Q N
Sbjct: 559 GEIGGIIGTNDVKTLADVNGVIEEEFTMARLYISKMKSEVKSLVNRSKQLESAQMDSN-- 616
Query: 131 SMLLENLTDNESENTNLKKKVFEKEAHIQELSCLFQS--EKANTLKANRFSQSVKVVHER 188
+ +E E + + + EA I+ L+ Q+ +K L+ ++ S S ++ R
Sbjct: 617 ----RKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQLEESQDSLSEELAKLR 672
Query: 189 LQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKV 248
Q ++H+ + DK KE++ L+ +A MK+A Q+ + ++A +
Sbjct: 673 AQEKMHEVSFQ-DKEKEHLTRLQ---------------DAEEMKKALEQQMESHREAHQK 716
Query: 249 YKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQ 308
RL +K+ +IRD KL S Y K+ IE E E+++E K
Sbjct: 717 QLSRLRDEIEEKQKIIDEIRDLNQKLQ---LEQEKLSSDYNKLKIEDQEREMKLE--KLL 771
Query: 309 IIN-----LLEDLKKMEDHGKNSCEEI--LRKVHSIEYE---NETLNLENTKLKTTLAAL 358
++N EDLK +E+ + + LRK+ + +++ L+N + AA
Sbjct: 772 LLNDKREQAREDLKGLEETVSRELQTLHNLRKLFVQDLTTRVKKSVELDNDDGGGS-AAQ 830
Query: 359 KDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTK 418
K ++ +EN L +L +V K+ + ++ KL++ R + L K
Sbjct: 831 KQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKAL----ESALKEA 886
Query: 419 NKNVEKMRGQMESHLKELERVCDSLTAAE--RRLHECQ 454
+N + R + + +E++R+ +++ A RR H Q
Sbjct: 887 KENAMRDR---KRYQQEVDRIKEAVRAKNMARRAHSAQ 921
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 94.4 bits (233), Expect = 3e-19
Identities = 141/683 (20%), Positives = 297/683 (43%), Gaps = 110/683 (16%)
Query: 27 LPRCTSESHLSCLK-QDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANL 85
L + E H + K +++ E L+ T+ + +T + L + T++ + E +
Sbjct: 965 LAKVEKEKHATENKVKNLTEEMAGLDETIAK---LTKEKKALQEAHQQTLDDLQAEEDKV 1021
Query: 86 SALN---LKISEQKEILIKELDTFKSVKLALEHLLRK----------------RDYKQTG 126
+ L +K+ +Q + L L+ K +++ LE RK D +Q
Sbjct: 1022 NTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLD 1081
Query: 127 DNLS------SMLLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANR--- 177
+ L S L + D ++ L+KK+ E +A I+EL ++E+A+ KA +
Sbjct: 1082 EKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRS 1141
Query: 178 -FSQSVKVVHERL---------QIQIH-KREAENDKLKEYV-------KSLETKIAKWNL 219
S+ ++ + ERL QI+++ KREAE K++ + ++ + K +
Sbjct: 1142 DLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHA 1201
Query: 220 QSRMNKNEAIVMKEASRQKTVALKKASKV--------------YKQRLDHFTGAIEKLTS 265
S E I + +QK K K+ K L+ A+E S
Sbjct: 1202 DSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLS 1261
Query: 266 QIRDQEAKLSETISASNAWKS-------HYEKIVIEKTELEVQIETMKKQIINLLEDLKK 318
+I+ +E + I+ A ++ Y + + EK L Q+ K+ +E+LK+
Sbjct: 1262 EIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKR 1321
Query: 319 MEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQ---EV 375
+ + + + S ++ + L + + + A L+ + +E+++ + E
Sbjct: 1322 QLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYET 1381
Query: 376 EKKQKT--LIEMYKTQVQKLQEA---AEIVKSRCENLLHKNNQITKTKNKNVEKMRGQME 430
+ Q+T L E K Q+LQ+A E V ++C +L K ++++ ++E
Sbjct: 1382 DAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASL-----------EKTKQRLQNEVE 1430
Query: 431 SHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSL 490
+ ++ER + A +++ + L K KC E T EL+ + +L T+L
Sbjct: 1431 DLMIDVERTNAACAALDKKQRNFDKILAEWKQKC---EETHAELEASQKESRSLSTEL-- 1485
Query: 491 EEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEK---SAEYTALA 547
I+ E +LE + ENK L++++++ E + + E +
Sbjct: 1486 ----FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEK 1541
Query: 548 RQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQ 607
+L+AALEE + E K+ +Q+++ +++E+ +K E+++ + +M K H
Sbjct: 1542 SELQAALEEAEASLEHEEGKI----LRIQLELNQVKSEVDRKIAEKDEEIDQM--KRNHI 1595
Query: 608 EVCLKEVQNSLE-KSENQNESIK 629
+ ++ +Q++L+ + ++N++I+
Sbjct: 1596 RI-VESMQSTLDAEIRSRNDAIR 1617
Score = 87.8 bits (216), Expect = 3e-17
Identities = 154/714 (21%), Positives = 310/714 (43%), Gaps = 124/714 (17%)
Query: 23 EKEDLPRCTSESHLSCLKQDILNEKTELE-----ATLKEAELVTHSVELLL-PLFKDTIE 76
E E++ E+ + Q +N+K E E L+EA L + L D++
Sbjct: 1146 ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVA 1205
Query: 77 KINFENANLSALNLKISEQKEILIKELD-------TFKSVKLALEHLLRKRDYK----QT 125
++ + NL + K+ ++K + E+D T K LE + R + + +T
Sbjct: 1206 ELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKT 1265
Query: 126 GDNLSSMLLENLTDN----ESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQS 181
+ L+ +LT ++E+ +++ EK+ + +LS Q+ F+Q
Sbjct: 1266 KEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQA----------FTQQ 1315
Query: 182 VKVVHERLQIQIHKREA----------ENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVM 231
++ + +L+ +I + A + D L+E + E + AK LQ M+K + V
Sbjct: 1316 IEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYE--EEQEAKAELQRAMSKANSEVA 1373
Query: 232 KEASR------QKTVALKKASKVYKQRL----DHFTG------AIEKLTSQIRDQEAKLS 275
+ ++ Q+T L++A K QRL +H ++EK +++++ L
Sbjct: 1374 QWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLM 1433
Query: 276 ETISASNAW-------KSHYEKIVIEKT----ELEVQIETMKKQIINLLEDLKKMEDHGK 324
+ +NA + +++KI+ E E ++E +K+ +L +L K+ K
Sbjct: 1434 IDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKI----K 1489
Query: 325 NSCEEILRKVHSIEYENETLNLENTKLKTTLAA-------LKDEVVSVENELSELQEVEK 377
N+ EE L ++ +++ EN+ L E + L +A L+ VE E SELQ +
Sbjct: 1490 NAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALE 1549
Query: 378 KQKTLIEMYKTQVQKLQEAAEIVKSRCEN-LLHKNNQITKTKNKN---VEKMRGQMESHL 433
+ + +E + ++ ++Q VKS + + K+ +I + K + VE M+ +++ +
Sbjct: 1550 EAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEI 1609
Query: 434 KELERVCDSLTAAERRLHECQ-----------ESLQCCKGKCADQEHTIRELQGQVDGNH 482
+ E L+E + E+L+ + A + T L +
Sbjct: 1610 RSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQE 1669
Query: 483 NLLTKLSLEEENC-LIQLKCENLQQKLEQMDAENKELEKKL--ANQEECLKHS------N 533
+L +L++ E L+Q + E L+ LEQ + K E++L A++ L H+ N
Sbjct: 1670 DLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLIN 1729
Query: 534 LKFKEKSAEYTALARQLEAALEEGRQ-------------KVAEEIEKMSSRESALQIKIL 580
K K+ + + + ++E ++E R +AEE++K + L+
Sbjct: 1730 TK-KKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1788
Query: 581 DLE---TELRKKNEEQNQLVCKMNSK-AQHQEVCLKEVQNSLEKSENQN-ESIK 629
+LE +L+ + +E QL K K Q E ++E++ +E + +N E++K
Sbjct: 1789 NLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVK 1842
Score = 72.4 bits (176), Expect = 1e-12
Identities = 93/436 (21%), Positives = 199/436 (45%), Gaps = 60/436 (13%)
Query: 202 KLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIE 261
K+K +KS ET+ N++ K + + K +++K + K + + ++
Sbjct: 839 KIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKN--------- 889
Query: 262 KLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMED 321
L Q++ + L++ + ++++ K +LE +I K++ ED +++
Sbjct: 890 DLQLQVQAEADSLADA-------EERCDQLIKTKIQLEAKI----KEVTERAEDEEEIN- 937
Query: 322 HGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSEL-QEVEKKQK 380
E+ K +E E L + L+ TLA ++ E + EN++ L +E+ +
Sbjct: 938 ------AELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDE 991
Query: 381 TLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVC 440
T+ ++ K + + LQEA + + K N +TK K K +E+ +E L++ +++
Sbjct: 992 TIAKLTKEK-KALQEAHQQTLDDLQAEEDKVNTLTKAKIK-LEQQVDDLEGSLEQEKKIR 1049
Query: 441 DSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKL--SLEEENCLIQ 498
L A+R+L + L+ + D E+ ++L ++ ++ L +E+E L
Sbjct: 1050 MDLERAKRKL---EGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGM 1106
Query: 499 LKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGR 558
LQ+K++++ A +ELE+++ E + S K +++ ++ + ++ LEE
Sbjct: 1107 ----QLQKKIKELQARIEELEEEI----EAERASRAKAEKQRSDLSRELEEISERLEEAG 1158
Query: 559 QKVAEEIEKMSSRESALQIKILDLE----------TELRKKNEEQNQLVCKMNSKAQHQE 608
+ +IE RE+ Q DLE LRKK+ + V ++ + +
Sbjct: 1159 GATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADS---VAELGEQIDN-- 1213
Query: 609 VCLKEVQNSLEKSENQ 624
L+ V+ LEK +++
Sbjct: 1214 --LQRVKQKLEKEKSE 1227
Score = 58.9 bits (141), Expect = 1e-08
Identities = 79/401 (19%), Positives = 168/401 (41%), Gaps = 50/401 (12%)
Query: 36 LSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFE-NANLSALNLKISE 94
L +K+ + EK+EL+A L+EAE E I +I E N S ++ KI+E
Sbjct: 1530 LEKIKKQVEQEKSELQAALEEAEASLEHEE-------GKILRIQLELNQVKSEVDRKIAE 1582
Query: 95 QKEILIKELDTFK--------SVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESENTN 146
+ E E+D K S++ L+ +R R+ L + +L + E + +
Sbjct: 1583 KDE----EIDQMKRNHIRIVESMQSTLDAEIRSRN---DAIRLKKKMEGDLNEMEIQLNH 1635
Query: 147 LKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEY 206
+ E + + + + + + A R + +K ++ + + +AE ++L+
Sbjct: 1636 ANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRAT 1695
Query: 207 VKSLET--KIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLT 264
++ E KIA+ Q ++ +E + + + KK + + G +E +
Sbjct: 1696 LEQTERSRKIAE---QELLDASERVQLLHTQNTSLINTKKKLET---DISQIQGEMEDII 1749
Query: 265 SQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDH-- 322
+ R+ E K + I+ + +K + + +E MKK + ++DL+ D
Sbjct: 1750 QEARNAEEKAKKAITDAAMMAEELKK----EQDTSAHLERMKKNLEQTVKDLQHRLDEAE 1805
Query: 323 ------GKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSE----- 371
GK +++ +V +E E E+ N + L + +V + + E
Sbjct: 1806 QLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNI 1865
Query: 372 --LQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHK 410
LQ++ K + ++ YK Q ++ +E + + S+ + H+
Sbjct: 1866 LRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHE 1906
Score = 56.6 bits (135), Expect = 7e-08
Identities = 87/488 (17%), Positives = 207/488 (42%), Gaps = 57/488 (11%)
Query: 40 KQDILNEKTELEATLKEAELVTHSVELLLPLFK---DTIEKINFENANL----SALNLKI 92
KQ ELEA+ KE+ ++ + + ++ D +E + EN NL S L +I
Sbjct: 1461 KQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQI 1520
Query: 93 SE------QKEILIKELDTFKS-VKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESENT 145
+E + E + K+++ KS ++ ALE ++++ G L L N +E +
Sbjct: 1521 AEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEE-GKILRIQLELNQVKSEVD-- 1577
Query: 146 NLKKKVFEKEAHIQELS-----------CLFQSEKANTLKANRFSQSVKVVHERLQIQI- 193
+K+ EK+ I ++ +E + A R + ++ ++IQ+
Sbjct: 1578 ---RKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLN 1634
Query: 194 HKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRL 253
H + L+ Y + I K ++++ ++A+ +E +++ +++ + + + +
Sbjct: 1635 HANRMAAEALRNYRNT--QAILK---DTQLHLDDALRSQEDLKEQLAMVERRANLLQAEI 1689
Query: 254 DHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLL 313
+ +E+ + E +L + + ++ K +LE I ++ ++ +++
Sbjct: 1690 EELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDII 1749
Query: 314 EDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQ 373
++ + E+ K + + ++ E +T + L+ L+ V +++ L E +
Sbjct: 1750 QEARNAEEKAKKAITDAAMMAEELKKEQDT----SAHLERMKKNLEQTVKDLQHRLDEAE 1805
Query: 374 EVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKN---VEKMRGQME 430
++ K K Q+QKL+ ++ E+ +N + K K+ V+++ Q E
Sbjct: 1806 QLALKGG------KKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTE 1859
Query: 431 SHLKELERVCD-------SLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHN 483
K + R+ D + + +R+ E +E K +H + E + + D +
Sbjct: 1860 EDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAES 1919
Query: 484 LLTKLSLE 491
+ KL ++
Sbjct: 1920 QVNKLRVK 1927
Score = 56.2 bits (134), Expect = 9e-08
Identities = 71/322 (22%), Positives = 146/322 (45%), Gaps = 51/322 (15%)
Query: 346 LENTKLKTTLAALKDEVVSVENELSELQ----EVEKKQKTLIEM---YKTQVQKLQEAAE 398
L++ + + +A +K+E + EL++ + E+E+K TL++ + QVQ ++
Sbjct: 844 LKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLA 903
Query: 399 IVKSRCENLLHKNNQITKTKNKNV-------EKMRGQMESHLKELERVCD---------- 441
+ RC+ L+ Q+ + K K V E++ ++ + ++LE C
Sbjct: 904 DAEERCDQLIKTKIQL-EAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 962
Query: 442 -SLTAAERRLHECQESLQCCKGKCADQEHTI----RELQGQVDGNHNLLTKLSLEEE--N 494
+L E+ H + ++ + A + TI +E + + + L L EE+ N
Sbjct: 963 LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVN 1022
Query: 495 CLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAAL 554
L + K + L+Q+++ ++ + E EKK+ E + K K LA++ +
Sbjct: 1023 TLTKAKIK-LEQQVDDLEG-SLEQEKKIRMDLE-------RAKRKLEGDLKLAQESTMDI 1073
Query: 555 EEGRQKVAEEIEKMSSRESALQIKILD---LETELRKKNEEQNQLVCKMNSKAQHQEVCL 611
E +Q++ E+++K S LQ KI D L +L+KK +E + ++ + E +
Sbjct: 1074 ENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKE-------LQARIEELEEEI 1126
Query: 612 KEVQNSLEKSENQNESIKNYLQ 633
+ + S K+E Q + L+
Sbjct: 1127 EAERASRAKAEKQRSDLSRELE 1148
Score = 39.7 bits (91), Expect = 0.009
Identities = 61/290 (21%), Positives = 119/290 (41%), Gaps = 44/290 (15%)
Query: 46 EKTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSALNLKISEQKEILIKELDT 105
E EL ATL++ E E L + ++ ++ +N +L +N K K+L+T
Sbjct: 1688 EIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSL--INTK---------KKLET 1736
Query: 106 -FKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESENTNLKKKVFEKEAHIQELSCL 164
++ +E ++ Q N + +TD LKK+ + AH++ +
Sbjct: 1737 DISQIQGEMEDII------QEARNAEEKAKKAITDAAMMAEELKKEQ-DTSAHLERMK-- 1787
Query: 165 FQSEKANTLKANRFSQSVKVVHERL----QIQIHKREAENDKLKEYVKSLETKIAKWNLQ 220
Q+VK + RL Q+ + + + KL+ V+ LE ++ +
Sbjct: 1788 -----------KNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEV-----E 1831
Query: 221 SRMNKN-EAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETIS 279
S +N EA+ +K L ++ ++ + ++KL ++++ + + E
Sbjct: 1832 SEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEE 1891
Query: 280 ASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEE 329
SN S + +I E E E + + + Q+ L +K E H K EE
Sbjct: 1892 QSNVNLSKFRRIQHELEEAEERADIAESQVNKL--RVKSREVHTKIISEE 1939
Score = 38.9 bits (89), Expect = 0.015
Identities = 36/155 (23%), Positives = 76/155 (49%), Gaps = 14/155 (9%)
Query: 484 LLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLAN----------QEECLKHSN 533
LL E+E ++ + E +++L + +A+ KELE+K+ Q + S
Sbjct: 843 LLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSL 902
Query: 534 LKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQ 593
+E+ + QLEA ++E ++ AE+ E++++ +A + K+ D +EL+K ++
Sbjct: 903 ADAEERCDQLIKTKIQLEAKIKEVTER-AEDEEEINAELTAKKRKLEDECSELKKDIDDL 961
Query: 594 NQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESI 628
+ K+ + E +V+N E+ +E+I
Sbjct: 962 ELTLAKVEKEKHATE---NKVKNLTEEMAGLDETI 993
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.124 0.325
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,688,117
Number of Sequences: 37866
Number of extensions: 905452
Number of successful extensions: 13405
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 358
Number of HSP's successfully gapped in prelim test: 1039
Number of HSP's that attempted gapping in prelim test: 5301
Number of HSP's gapped (non-prelim): 4182
length of query: 644
length of database: 18,247,518
effective HSP length: 109
effective length of query: 535
effective length of database: 14,120,124
effective search space: 7554266340
effective search space used: 7554266340
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.