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Search of human proteins with 54792096
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|54792096 erbB-2 isoform a [Homo sapiens]
(1255 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|54792096 erbB-2 isoform a [Homo sapiens] 2629 0.0
gi|54792098 erbB-2 isoform b [Homo sapiens] 2568 0.0
gi|29725609 epidermal growth factor receptor isoform a precursor... 1198 0.0
gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo... 1140 0.0
gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo... 1131 0.0
gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens] 921 0.0
gi|41327736 epidermal growth factor receptor isoform d precursor... 580 e-165
gi|41327732 epidermal growth factor receptor isoform b precursor... 580 e-165
gi|41327734 epidermal growth factor receptor isoform c precursor... 363 e-100
gi|32967311 ephrin receptor EphA2 [Homo sapiens] 215 2e-55
gi|32528301 EPH receptor B4 precursor [Homo sapiens] 214 4e-55
gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens] 211 3e-54
gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo sap... 206 9e-53
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens] 206 9e-53
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens] 206 9e-53
gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 204 3e-52
gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo... 204 3e-52
gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 204 3e-52
gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 204 3e-52
gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo sap... 204 4e-52
gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo sapi... 202 1e-51
gi|4758280 ephrin receptor EphA4 [Homo sapiens] 202 1e-51
gi|17975768 ephrin receptor EphB3 precursor [Homo sapiens] 202 1e-51
gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo sap... 202 2e-51
gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo sap... 201 4e-51
gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo sap... 201 4e-51
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 201 5e-51
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 201 5e-51
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 201 5e-51
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 201 5e-51
>gi|54792096 erbB-2 isoform a [Homo sapiens]
Length = 1255
Score = 2629 bits (6815), Expect = 0.0
Identities = 1255/1255 (100%), Positives = 1255/1255 (100%)
Query: 1 MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNL 60
MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNL
Sbjct: 1 MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNL 60
Query: 61 ELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG 120
ELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
Sbjct: 61 ELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG 120
Query: 121 DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLA 180
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLA
Sbjct: 121 DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLA 180
Query: 181 LTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQC 240
LTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQC
Sbjct: 181 LTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQC 240
Query: 241 AAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP 300
AAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
Sbjct: 241 AAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP 300
Query: 301 YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSAN 360
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSAN
Sbjct: 301 YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSAN 360
Query: 361 IQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLP 420
IQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLP
Sbjct: 361 IQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLP 420
Query: 421 DLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV 480
DLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
Sbjct: 421 DLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV 480
Query: 481 PWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQEC 540
PWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQEC
Sbjct: 481 PWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQEC 540
Query: 541 VEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARC 600
VEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARC
Sbjct: 541 VEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARC 600
Query: 601 PSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVG 660
PSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVG
Sbjct: 601 PSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVG 660
Query: 661 ILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETEL 720
ILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETEL
Sbjct: 661 ILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETEL 720
Query: 721 RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSP 780
RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSP
Sbjct: 721 RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSP 780
Query: 781 YVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVR 840
YVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVR
Sbjct: 781 YVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVR 840
Query: 841 LVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFT 900
LVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFT
Sbjct: 841 LVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFT 900
Query: 901 HQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWM 960
HQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWM
Sbjct: 901 HQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWM 960
Query: 961 IDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDA 1020
IDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDA
Sbjct: 961 IDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDA 1020
Query: 1021 EEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEG 1080
EEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEG
Sbjct: 1021 EEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEG 1080
Query: 1081 AGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYV 1140
AGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYV
Sbjct: 1081 AGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYV 1140
Query: 1141 NQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQ 1200
NQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQ
Sbjct: 1141 NQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQ 1200
Query: 1201 GGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV 1255
GGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV
Sbjct: 1201 GGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV 1255
>gi|54792098 erbB-2 isoform b [Homo sapiens]
Length = 1225
Score = 2568 bits (6657), Expect = 0.0
Identities = 1225/1225 (100%), Positives = 1225/1225 (100%)
Query: 31 MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQ 90
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQ
Sbjct: 1 MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQ 60
Query: 91 VRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILK 150
VRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILK
Sbjct: 61 VRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILK 120
Query: 151 GGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE 210
GGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
Sbjct: 121 GGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE 180
Query: 211 DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPA 270
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPA
Sbjct: 181 DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPA 240
Query: 271 LVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQR 330
LVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQR
Sbjct: 241 LVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQR 300
Query: 331 CEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA 390
CEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
Sbjct: 301 CEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA 360
Query: 391 PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGI 450
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGI
Sbjct: 361 PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGI 420
Query: 451 SWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLA 510
SWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLA
Sbjct: 421 SWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLA 480
Query: 511 CHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQ 570
CHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQ
Sbjct: 481 CHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQ 540
Query: 571 NGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINC 630
NGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINC
Sbjct: 541 NGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINC 600
Query: 631 THSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRL 690
THSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRL
Sbjct: 601 THSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRL 660
Query: 691 LQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPV 750
LQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPV
Sbjct: 661 LQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPV 720
Query: 751 AIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHV 810
AIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHV
Sbjct: 721 AIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHV 780
Query: 811 RENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLL 870
RENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLL
Sbjct: 781 RENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLL 840
Query: 871 DIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPARE 930
DIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPARE
Sbjct: 841 DIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPARE 900
Query: 931 IPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQ 990
IPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQ
Sbjct: 901 IPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQ 960
Query: 991 NEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSS 1050
NEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSS
Sbjct: 961 NEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSS 1020
Query: 1051 STRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQ 1110
STRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQ
Sbjct: 1021 STRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQ 1080
Query: 1111 RYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERP 1170
RYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERP
Sbjct: 1081 RYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERP 1140
Query: 1171 KTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPER 1230
KTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPER
Sbjct: 1141 KTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPER 1200
Query: 1231 GAPPSTFKGTPTAENPEYLGLDVPV 1255
GAPPSTFKGTPTAENPEYLGLDVPV
Sbjct: 1201 GAPPSTFKGTPTAENPEYLGLDVPV 1225
>gi|29725609 epidermal growth factor receptor isoform a precursor
[Homo sapiens]
Length = 1210
Score = 1198 bits (3099), Expect = 0.0
Identities = 628/1252 (50%), Positives = 802/1252 (64%), Gaps = 80/1252 (6%)
Query: 11 LLLALLPPGAA--STQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTN 68
LL AL P A +VC GT KL + E H L+ ++ C+VV GNLE+TY+ N
Sbjct: 14 LLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRN 73
Query: 69 ASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTP 128
LSFL+ IQEV GYVLIA N V ++PL+ L+I+RG +E++YALAVL N D
Sbjct: 74 YDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYD------- 126
Query: 129 VTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNR 188
A+ GL+EL +R+L EIL G V NP LC ++I W+DI + +++ N
Sbjct: 127 ---ANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNH 183
Query: 189 SRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCA-RCKGPLPTDCCHEQCAAGCTGP 247
+C C P C CWG E+CQ LT+ +CA C+ RC+G P+DCCH QCAAGCTGP
Sbjct: 184 LGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGP 243
Query: 248 KHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTD 307
+ SDCL C F C+ CP L+ YN T++ NPEG+Y+FGA+CV CP NY+ TD
Sbjct: 244 RESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTD 303
Query: 308 VGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGC 367
GSC C + E+ EDG ++C+KC PC +VC G+G+ ++ ++ + NI+ F C
Sbjct: 304 HGSCVRACGADSYEME-EDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNC 362
Query: 368 KKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQN 427
I G L LP +F GD ++T PL P++L + +T++EITG+L I AWP++ DL F+N
Sbjct: 363 TSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFEN 422
Query: 428 LQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFR 487
L++IRGR +G +SL + L I+ LGLRSL+E+ G +I N +LC+ +T+ W +LF
Sbjct: 423 LEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFG 482
Query: 488 NPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVL 547
Q +NR E+ C G CH LC+ CWGP P CV+C RG+ECV++C +L
Sbjct: 483 TSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLL 542
Query: 548 QGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPD 607
+G PRE+V C+ CHPEC PQ ++TC G D C+ CAHY D P CV CP+GV +
Sbjct: 543 EGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGE 602
Query: 608 LSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVL 667
+ + +WK+ D C C NCT+ C +GCP P SI + +VG LL++++
Sbjct: 603 NNTL-VWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIP--SIATGMVGALLLLLV 659
Query: 668 GVVFGI-LIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVL 726
V GI L RR+ +RK T+RRLLQE ELVEPLTPSG PNQA +RILKETE +K+KVL
Sbjct: 660 -VALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVL 718
Query: 727 GSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLL 786
GSGAFGTVYKG+WIP+GE VKIPVAIK LRE TSPKANKEILDEAYVMA V +P+V RLL
Sbjct: 719 GSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLL 778
Query: 787 GICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDL 846
GICLTSTVQL+TQLMP+GCLLD+VRE++ +GSQ LLNWC+QIAKGM+YLED RLVHRDL
Sbjct: 779 GICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDL 838
Query: 847 AARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVW 906
AARNVLVK+P HVKITDFGLA+LL +E EYHA+GGKVPIKWMALESIL R +THQSDVW
Sbjct: 839 AARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVW 898
Query: 907 SYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECR 966
SYGVTVWELMTFG+KPYDGIPA EI +LEKGERLPQPPICTIDVYMIMVKCWMID++ R
Sbjct: 899 SYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSR 958
Query: 967 PRFRELVSEFSRMARDPQRFVVIQ-NEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLV 1025
P+FREL+ EFS+MARDPQR++VIQ +E + SP DS FYR+L++++DM D+VDA+EYL+
Sbjct: 959 PKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLI 1018
Query: 1026 PQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDV 1085
PQQGFF S R+PL S A S+
Sbjct: 1019 PQQGFF----------------------------------SSPSTSRTPLLSSLSATSN- 1043
Query: 1086 FDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDV 1145
+ + GLQS P + S LQRYS DPT L ++ T P PEY+NQ V
Sbjct: 1044 -NSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDS----IDDTFLPVPEYINQ-SV 1097
Query: 1146 RPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYL-TPQGGAA 1204
+P + P+ +P +P ++ +D AV NPEYL T Q
Sbjct: 1098 PKRPAGSVQNPVYHNQPLNP--------APSRDPHYQD--PHSTAVGNPEYLNTVQPTCV 1147
Query: 1205 PQPHPPPA-------FSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYL 1249
PA + DN Y P+ P FKG+ TAEN EYL
Sbjct: 1148 NSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGS-TAENAEYL 1198
>gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-2 precursor [Homo sapiens]
Length = 1292
Score = 1140 bits (2948), Expect = 0.0
Identities = 602/1261 (47%), Positives = 785/1261 (62%), Gaps = 75/1261 (5%)
Query: 22 STQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQ 81
S VC GT+ KL + E LR Y+ C+VV GNLE+T + N LSFL+ ++EV
Sbjct: 25 SQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVT 84
Query: 82 GYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQ 141
GYVL+A NQ R +PL+ LRI+RGT+L+ED YALA+ N N GL+EL
Sbjct: 85 GYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNF---------GLQELG 135
Query: 142 LRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKG 201
L++LTEIL GGV + +N LCY DTI W+DI LTL+ TN S C C C G
Sbjct: 136 LKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTG 195
Query: 202 SRCWGESSEDCQSLTRTVCAGGC-ARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNH 260
RCWG + CQ+LTRTVCA C RC GP +DCCH +CA GC+GPK +DC AC++FN
Sbjct: 196 -RCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFND 254
Query: 261 SGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQ 320
SG C CP YN TF+ N +YT+GA CV CP+N++ D SC CP
Sbjct: 255 SGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFV-VDSSSCVRACPSSKM 313
Query: 321 EVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPES 380
EV E+G + C+ C+ C + C G+G L + V S+NI +F C KI G+L FL
Sbjct: 314 EVE-ENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTG 372
Query: 381 FDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGA 440
GDP + + PE+L VF T+ EITG+L I +WP ++ D SVF NL I GR+L++G
Sbjct: 373 IHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGL 432
Query: 441 YSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRP 500
L L+ GI+ L +SL+E+ +G I N++LC+ HT+ W LF +Q ++ NR
Sbjct: 433 SLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRK 492
Query: 501 EDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHC 560
+ C EG+ C+ LC+ CWGPGP QC++C +F RG+ C+E C + G RE+ N C
Sbjct: 493 AENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSIC 552
Query: 561 LPCHPECQP-QNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDE 619
+ C P+C+ ++G +TC GP D C C+H+KD P CV +CP G++ S+ I+K+ D
Sbjct: 553 VECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSF--IFKYADP 610
Query: 620 EGACQPCPINCTHSCVDLDDKGC-----------PAEQRASPLTSIISAVV--GILLVVV 666
+ C PC NCT C C P R T +I+A V G+ ++V+
Sbjct: 611 DRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHAR----TPLIAAGVIGGLFILVI 666
Query: 667 LGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVL 726
+G+ F + ++R+ K +K +RR L ETELVEPLTPSG PNQAQ+RILKETEL++VKVL
Sbjct: 667 VGLTFAVYVRRKSIK-KKRALRRFL-ETELVEPLTPSGTAPNQAQLRILKETELKRVKVL 724
Query: 727 GSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLL 786
GSGAFGTVYKGIW+P+GE VKIPVAIK+L E T PKAN E +DEA +MA + P++ RLL
Sbjct: 725 GSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLL 784
Query: 787 GICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDL 846
G+CL+ T+QLVTQLMP+GCLL++V E++ +GSQ LLNWC+QIAKGM YLE+ RLVHRDL
Sbjct: 785 GVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDL 844
Query: 847 AARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVW 906
AARNVLVKSPNHVKITDFGLARLL+ DE EY+ADGGK+PIKWMALE I R+FTHQSDVW
Sbjct: 845 AARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVW 904
Query: 907 SYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECR 966
SYGVT+WELMTFG KPYDGIP REIPDLLEKGERLPQPPICTIDVYM+MVKCWMID++ R
Sbjct: 905 SYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSR 964
Query: 967 PRFRELVSEFSRMARDPQRFVVIQNED-LGPASPLDSTFYRSLLEDDDMGDLVDAEEYLV 1025
P+F+EL +EFSRMARDPQR++VIQ +D + SP DS F+++LL+++D+ D++DAEEYLV
Sbjct: 965 PKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLV 1024
Query: 1026 PQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLE-PSEEEAPRSPLAP-SEGAGS 1083
P Q F P P + + R GG G+ P P AP ++GA +
Sbjct: 1025 P-QAFNIPPPIYTSRARIDSNRNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATA 1083
Query: 1084 DVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPS-------ETDGYVAPLTCSPQ 1136
++FD G + + + S QRYS DPTV P + +GY+ P+ P+
Sbjct: 1084 EIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPK 1143
Query: 1137 PEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEY 1196
EY+N + P + G L A L+ P+ NG K A V P Y
Sbjct: 1144 QEYLNPVEENPFVSRRKNGDLQA-------LDNPE-YHNASNGPPK---AEDEYVNEPLY 1192
Query: 1197 LTPQGGAAPQPH--------PPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEY 1248
L + P AFDN YW+ P R T ++P+Y
Sbjct: 1193 LNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRS----------TLQHPDY 1242
Query: 1249 L 1249
L
Sbjct: 1243 L 1243
>gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-1 precursor [Homo sapiens]
Length = 1308
Score = 1131 bits (2925), Expect = 0.0
Identities = 601/1282 (46%), Positives = 788/1282 (61%), Gaps = 101/1282 (7%)
Query: 22 STQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQ 81
S VC GT+ KL + E LR Y+ C+VV GNLE+T + N LSFL+ ++EV
Sbjct: 25 SQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVT 84
Query: 82 GYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQ 141
GYVL+A NQ R +PL+ LRI+RGT+L+ED YALA+ N N GL+EL
Sbjct: 85 GYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNF---------GLQELG 135
Query: 142 LRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKG 201
L++LTEIL GGV + +N LCY DTI W+DI LTL+ TN S C C C G
Sbjct: 136 LKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTG 195
Query: 202 SRCWGESSEDCQSLTRTVCAGGC-ARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNH 260
RCWG + CQ+LTRTVCA C RC GP +DCCH +CA GC+GPK +DC AC++FN
Sbjct: 196 -RCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFND 254
Query: 261 SGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQ 320
SG C CP YN TF+ N +YT+GA CV CP+N++ D SC CP
Sbjct: 255 SGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFV-VDSSSCVRACPSSKM 313
Query: 321 EVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPES 380
EV E+G + C+ C+ C + C G+G L + V S+NI +F C KI G+L FL
Sbjct: 314 EVE-ENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTG 372
Query: 381 FDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGA 440
GDP + + PE+L VF T+ EITG+L I +WP ++ D SVF NL I GR+L++G
Sbjct: 373 IHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGL 432
Query: 441 YSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRP 500
L L+ GI+ L +SL+E+ +G I N++LC+ HT+ W LF +Q ++ NR
Sbjct: 433 SLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRK 492
Query: 501 EDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHC 560
+ C EG+ C+ LC+ CWGPGP QC++C +F RG+ C+E C + G RE+ N C
Sbjct: 493 AENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSIC 552
Query: 561 LPCHPECQP-QNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDE 619
+ C P+C+ ++G +TC GP D C C+H+KD P CV +CP G++ S+ I+K+ D
Sbjct: 553 VECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSF--IFKYADP 610
Query: 620 EGACQPCPINCTHSCVDLDDKGC-----------PAEQRASPLTSIISAVV--GILLVVV 666
+ C PC NCT C C P R T +I+A V G+ ++V+
Sbjct: 611 DRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHAR----TPLIAAGVIGGLFILVI 666
Query: 667 LGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVL 726
+G+ F + ++R+ K +K +RR L ETELVEPLTPSG PNQAQ+RILKETEL++VKVL
Sbjct: 667 VGLTFAVYVRRKSIK-KKRALRRFL-ETELVEPLTPSGTAPNQAQLRILKETELKRVKVL 724
Query: 727 GSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLL 786
GSGAFGTVYKGIW+P+GE VKIPVAIK+L E T PKAN E +DEA +MA + P++ RLL
Sbjct: 725 GSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLL 784
Query: 787 GICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDL 846
G+CL+ T+QLVTQLMP+GCLL++V E++ +GSQ LLNWC+QIAKGM YLE+ RLVHRDL
Sbjct: 785 GVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDL 844
Query: 847 AARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVW 906
AARNVLVKSPNHVKITDFGLARLL+ DE EY+ADGGK+PIKWMALE I R+FTHQSDVW
Sbjct: 845 AARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVW 904
Query: 907 SYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECR 966
SYGVT+WELMTFG KPYDGIP REIPDLLEKGERLPQPPICTIDVYM+MVKCWMID++ R
Sbjct: 905 SYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSR 964
Query: 967 PRFRELVSEFSRMARDPQRFVVIQNED-LGPASPLDSTFYRSLLEDDDMGDLVDAEEYLV 1025
P+F+EL +EFSRMARDPQR++VIQ +D + SP DS F+++LL+++D+ D++DAEEYLV
Sbjct: 965 PKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLV 1024
Query: 1026 PQQGFFCPDP-----------------------APGAGGMVHHRHRSSSTRSGGGDLTLG 1062
P Q F P P P +G +R + G +++
Sbjct: 1025 P-QAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQG---VSVP 1080
Query: 1063 LEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPS 1122
P +P+A +GA +++FD G + + + S QRYS DPTV P
Sbjct: 1081 YRAPTSTIPEAPVA--QGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPE 1138
Query: 1123 -------ETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSP 1175
+ +GY+ P+ P+ EY+N + P + G L A L+ P+
Sbjct: 1139 RSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQA-------LDNPE-YHN 1190
Query: 1176 GKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPH--------PPPAFSPAFDNLYYWDQDP 1227
NG K A V P YL + P AFDN YW+
Sbjct: 1191 ASNGPPK---AEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSL 1247
Query: 1228 PERGAPPSTFKGTPTAENPEYL 1249
P R T ++P+YL
Sbjct: 1248 PPRS----------TLQHPDYL 1259
>gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens]
Length = 1342
Score = 921 bits (2380), Expect = 0.0
Identities = 470/983 (47%), Positives = 621/983 (63%), Gaps = 31/983 (3%)
Query: 22 STQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQ 81
S VC GT L + E L LY+ C+VV GNLE+ NA LSFLQ I+EV
Sbjct: 25 SQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVT 84
Query: 82 GYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQ 141
GYVL+A N+ +PL LR+VRGTQ+++ +A+ V+ N NT S LR+L+
Sbjct: 85 GYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLN----YNTN-----SSHALRQLR 135
Query: 142 LRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKG 201
L LTEIL GGV I++N +LC+ DTI W+DI + ++ + R+C PC +CKG
Sbjct: 136 LTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDA---EIVVKDNGRSCPPCHEVCKG 192
Query: 202 SRCWGESSEDCQSLTRTVCAGGC-ARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNH 260
RCWG SEDCQ+LT+T+CA C C GP P CCH++CA GC+GP+ +DC AC HFN
Sbjct: 193 -RCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFND 251
Query: 261 SGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQ 320
SG C CP + YN TF+ PNP +Y +G CV +CP+N++ D SC CP
Sbjct: 252 SGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFV-VDQTSCVRACPPDKM 310
Query: 321 EVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPES 380
EV ++G + CE C C + C G G + V S+NI F C KI G+L FL
Sbjct: 311 EVD-KNGLKMCEPCGGLCPKACEGTGSGS--RFQTVDSSNIDGFVNCTKILGNLDFLITG 367
Query: 381 FDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGA 440
+GDP L PE+L VF T+ EITGYL I +WP + + SVF NL I GR L+N
Sbjct: 368 LNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRG 427
Query: 441 YSLTL-QGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTA-N 498
+SL + + L ++ LG RSL+E+ +G I N LC+ H++ W ++ R P + L N
Sbjct: 428 FSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHN 487
Query: 499 RPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNAR 558
RP +CV EG C LC+ G CWGPGP QC++C + RG CV C L G PRE+ +
Sbjct: 488 RPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEA 547
Query: 559 HCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPD 618
C CHPECQP G+ TC G +D C CAH++D P CV+ CP GV PI+K+PD
Sbjct: 548 ECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKG--PIYKYPD 605
Query: 619 EEGACQPCPINCTHSCVDLDDKGCPAEQRA----SPLTSIISAVVGILLVVVLGVVFGIL 674
+ C+PC NCT C + + C + + LT ++ + G LVV+ ++ G
Sbjct: 606 VQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAG--LVVIFMMLGGTF 663
Query: 675 IKRRQQKIR-KYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGT 733
+ R ++I+ K MRR L+ E +EPL PS N+ RI KETELRK+KVLGSG FGT
Sbjct: 664 LYWRGRRIQNKRAMRRYLERGESIEPLDPS-EKANKVLARIFKETELRKLKVLGSGVFGT 722
Query: 734 VYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTST 793
V+KG+WIP+GE++KIPV IKV+ + + ++ + + D + + ++ RLLG+C S+
Sbjct: 723 VHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSS 782
Query: 794 VQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLV 853
+QLVTQ +P G LLDHVR++RG LG Q LLNW +QIAKGM YLE+ +VHR+LAARNVL+
Sbjct: 783 LQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLL 842
Query: 854 KSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVW 913
KSP+ V++ DFG+A LL D+ + K PIKWMALESI ++THQSDVWSYGVTVW
Sbjct: 843 KSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVW 902
Query: 914 ELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELV 973
ELMTFGA+PY G+ E+PDLLEKGERL QP ICTIDVYM+MVKCWMID RP F+EL
Sbjct: 903 ELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELA 962
Query: 974 SEFSRMARDPQRFVVIQNEDLGP 996
+EF+RMARDP R++VI+ E GP
Sbjct: 963 NEFTRMARDPPRYLVIKRES-GP 984
>gi|41327736 epidermal growth factor receptor isoform d precursor
[Homo sapiens]
Length = 705
Score = 580 bits (1495), Expect = e-165
Identities = 275/625 (44%), Positives = 381/625 (60%), Gaps = 15/625 (2%)
Query: 11 LLLALLPPGAA--STQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTN 68
LL AL P A +VC GT KL + E H L+ ++ C+VV GNLE+TY+ N
Sbjct: 14 LLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRN 73
Query: 69 ASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTP 128
LSFL+ IQEV GYVLIA N V ++PL+ L+I+RG +E++YALAVL N D
Sbjct: 74 YDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYD------- 126
Query: 129 VTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNR 188
A+ GL+EL +R+L EIL G V NP LC ++I W+DI + +++ N
Sbjct: 127 ---ANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNH 183
Query: 189 SRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCA-RCKGPLPTDCCHEQCAAGCTGP 247
+C C P C CWG E+CQ LT+ +CA C+ RC+G P+DCCH QCAAGCTGP
Sbjct: 184 LGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGP 243
Query: 248 KHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTD 307
+ SDCL C F C+ CP L+ YN T++ NPEG+Y+FGA+CV CP NY+ TD
Sbjct: 244 RESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTD 303
Query: 308 VGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGC 367
GSC C + E+ EDG ++C+KC PC +VC G+G+ ++ ++ + NI+ F C
Sbjct: 304 HGSCVRACGADSYEME-EDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNC 362
Query: 368 KKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQN 427
I G L LP +F GD ++T PL P++L + +T++EITG+L I AWP++ DL F+N
Sbjct: 363 TSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFEN 422
Query: 428 LQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFR 487
L++IRGR +G +SL + L I+ LGLRSL+E+ G +I N +LC+ +T+ W +LF
Sbjct: 423 LEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFG 482
Query: 488 NPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVL 547
Q +NR E+ C G CH LC+ CWGP P CV+C RG+ECV++C +L
Sbjct: 483 TSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLL 542
Query: 548 QGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPD 607
+G PRE+V C+ CHPEC PQ ++TC G D C+ CAHY D P CV CP+GV +
Sbjct: 543 EGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGE 602
Query: 608 LSYMPIWKFPDEEGACQPCPINCTH 632
+ + +WK+ D C C NCT+
Sbjct: 603 NNTL-VWKYADAGHVCHLCHPNCTY 626
>gi|41327732 epidermal growth factor receptor isoform b precursor
[Homo sapiens]
Length = 628
Score = 580 bits (1495), Expect = e-165
Identities = 275/625 (44%), Positives = 381/625 (60%), Gaps = 15/625 (2%)
Query: 11 LLLALLPPGAA--STQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTN 68
LL AL P A +VC GT KL + E H L+ ++ C+VV GNLE+TY+ N
Sbjct: 14 LLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRN 73
Query: 69 ASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTP 128
LSFL+ IQEV GYVLIA N V ++PL+ L+I+RG +E++YALAVL N D
Sbjct: 74 YDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYD------- 126
Query: 129 VTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNR 188
A+ GL+EL +R+L EIL G V NP LC ++I W+DI + +++ N
Sbjct: 127 ---ANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNH 183
Query: 189 SRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCA-RCKGPLPTDCCHEQCAAGCTGP 247
+C C P C CWG E+CQ LT+ +CA C+ RC+G P+DCCH QCAAGCTGP
Sbjct: 184 LGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGP 243
Query: 248 KHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTD 307
+ SDCL C F C+ CP L+ YN T++ NPEG+Y+FGA+CV CP NY+ TD
Sbjct: 244 RESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTD 303
Query: 308 VGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGC 367
GSC C + E+ EDG ++C+KC PC +VC G+G+ ++ ++ + NI+ F C
Sbjct: 304 HGSCVRACGADSYEME-EDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNC 362
Query: 368 KKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQN 427
I G L LP +F GD ++T PL P++L + +T++EITG+L I AWP++ DL F+N
Sbjct: 363 TSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFEN 422
Query: 428 LQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFR 487
L++IRGR +G +SL + L I+ LGLRSL+E+ G +I N +LC+ +T+ W +LF
Sbjct: 423 LEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFG 482
Query: 488 NPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVL 547
Q +NR E+ C G CH LC+ CWGP P CV+C RG+ECV++C +L
Sbjct: 483 TSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLL 542
Query: 548 QGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPD 607
+G PRE+V C+ CHPEC PQ ++TC G D C+ CAHY D P CV CP+GV +
Sbjct: 543 EGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGE 602
Query: 608 LSYMPIWKFPDEEGACQPCPINCTH 632
+ + +WK+ D C C NCT+
Sbjct: 603 NNTL-VWKYADAGHVCHLCHPNCTY 626
>gi|41327734 epidermal growth factor receptor isoform c precursor
[Homo sapiens]
Length = 405
Score = 363 bits (931), Expect = e-100
Identities = 177/401 (44%), Positives = 244/401 (60%), Gaps = 14/401 (3%)
Query: 11 LLLALLPPGAA--STQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTN 68
LL AL P A +VC GT KL + E H L+ ++ C+VV GNLE+TY+ N
Sbjct: 14 LLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRN 73
Query: 69 ASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTP 128
LSFL+ IQEV GYVLIA N V ++PL+ L+I+RG +E++YALAVL N D
Sbjct: 74 YDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYD------- 126
Query: 129 VTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNR 188
A+ GL+EL +R+L EIL G V NP LC ++I W+DI + +++ N
Sbjct: 127 ---ANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNH 183
Query: 189 SRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCA-RCKGPLPTDCCHEQCAAGCTGP 247
+C C P C CWG E+CQ LT+ +CA C+ RC+G P+DCCH QCAAGCTGP
Sbjct: 184 LGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGP 243
Query: 248 KHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTD 307
+ SDCL C F C+ CP L+ YN T++ NPEG+Y+FGA+CV CP NY+ TD
Sbjct: 244 RESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTD 303
Query: 308 VGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGC 367
GSC C + E+ EDG ++C+KC PC +VC G+G+ ++ ++ + NI+ F C
Sbjct: 304 HGSCVRACGADSYEM-EEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNC 362
Query: 368 KKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITG 408
I G L LP +F GD ++T PL P++L + +T++EITG
Sbjct: 363 TSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITG 403
Score = 84.7 bits (208), Expect = 5e-16
Identities = 57/246 (23%), Positives = 101/246 (41%), Gaps = 43/246 (17%)
Query: 364 FAGCKKIFGSL--AFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPD 421
F C+ + G+L ++ ++D L +T++E+ GY+ I+ + +
Sbjct: 55 FNNCEVVLGNLEITYVQRNYD--------------LSFLKTIQEVAGYVLIAL---NTVE 97
Query: 422 LSVFQNLQVIRGRILHNGAYSLTLQG------LGISWLGLRSLRELGSGLALIHHNTHLC 475
+NLQ+IRG + + +Y+L + G+ L +R+L+E+ G +N LC
Sbjct: 98 RIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALC 157
Query: 476 FVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFL 535
V ++ W + + L + +G C C G CWG G C ++ +
Sbjct: 158 NVESIQWRDIVSSD---FLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKII 214
Query: 536 RGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPF 595
Q+C CR + C CH +C + C GP C+ C ++D
Sbjct: 215 CAQQCSGRCR--------GKSPSDC--CHNQC-----AAGCTGPRESDCLVCRKFRDEAT 259
Query: 596 CVARCP 601
C CP
Sbjct: 260 CKDTCP 265
>gi|32967311 ephrin receptor EphA2 [Homo sapiens]
Length = 976
Score = 215 bits (547), Expect = 2e-55
Identities = 132/374 (35%), Positives = 200/374 (53%), Gaps = 16/374 (4%)
Query: 646 QRASPLTSIISAVVG------ILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEP 699
Q SP S AV+G +LL+V+ GV F I +R+ Q+ R+ ++E ++P
Sbjct: 525 QTLSPEGSGNLAVIGGVAVGVVLLLVLAGVGFFIHRRRKNQRARQSPEDVYFSKSEQLKP 584
Query: 700 LTP-----SGAMPNQAQMRILKETE---LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVA 751
L + PNQA ++ E + + KV+G+G FG VYKG+ ++PVA
Sbjct: 585 LKTYVDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVA 644
Query: 752 IKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLT-STVQLVTQLMPYGCLLDHV 810
IK L+ + K + L EA +M + RL G+ + ++T+ M G L +
Sbjct: 645 IKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFL 704
Query: 811 RENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLL 870
RE G L+ IA GM YL ++ VHRDLAARN+LV S K++DFGL+R+L
Sbjct: 705 REKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVL 764
Query: 871 DID-ETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAR 929
+ D E Y GGK+PI+W A E+I R+FT SDVWS+G+ +WE+MT+G +PY +
Sbjct: 765 EDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNH 824
Query: 930 EIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVI 989
E+ + G RLP P C +Y +M++CW + RP+F ++VS ++ R P +
Sbjct: 825 EVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTL 884
Query: 990 QNEDLGPASPLDST 1003
+ D + L ST
Sbjct: 885 ADFDPRVSIRLPST 898
>gi|32528301 EPH receptor B4 precursor [Homo sapiens]
Length = 987
Score = 214 bits (545), Expect = 4e-55
Identities = 138/383 (36%), Positives = 209/383 (54%), Gaps = 21/383 (5%)
Query: 632 HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIR------KY 685
HS LD+ EQ A + AVVG++LV+V+ +V +L R+Q R K+
Sbjct: 523 HSQTQLDESEGWREQLALIAGT---AVVGVVLVLVV-IVVAVLCLRKQSNGREAEYSDKH 578
Query: 686 TMRRLLQETEL-VEPLTPSGAMPNQAQMRILKETELRKVK---VLGSGAFGTVYKGIWIP 741
+ T++ ++P T PN+A KE ++ VK V+G+G FG V +G
Sbjct: 579 GQYLIGHGTKVYIDPFTYED--PNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKA 636
Query: 742 DGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTST-VQLVTQL 800
G+ VAIK L+ + + +E L EA +M P + RL G+ S V ++T+
Sbjct: 637 PGKKESC-VAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEF 695
Query: 801 MPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVK 860
M G L +R N G+ L+ IA GM YL ++ VHRDLAARN+LV S K
Sbjct: 696 MENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCK 755
Query: 861 ITDFGLARLLD---IDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMT 917
++DFGL+R L+ D T + GGK+PI+W A E+I R+FT SD WSYG+ +WE+M+
Sbjct: 756 VSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMS 815
Query: 918 FGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFS 977
FG +PY + +++ + +E+ RLP PP C ++ +M+ CW D RPRF ++VS
Sbjct: 816 FGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALD 875
Query: 978 RMARDPQRFVVIQNEDLGPASPL 1000
+M R+P ++ E+ G + PL
Sbjct: 876 KMIRNPASLKIVARENGGASHPL 898
>gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]
Length = 984
Score = 211 bits (538), Expect = 3e-54
Identities = 129/361 (35%), Positives = 198/361 (54%), Gaps = 19/361 (5%)
Query: 656 SAVVGILLVVVLGVVFGILIKRR--------QQKIRKYTMRRLLQETEL-VEPLTPSGAM 706
SA G++ VV L + + ++R K++ Y+ R ++ ++P T
Sbjct: 545 SAAAGVVFVVSLVAISIVCSRKRAYSKEAVYSDKLQHYSTGRGSPGMKIYIDPFTYED-- 602
Query: 707 PNQAQMRILKETELRKVK---VLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKA 763
PN+A KE ++ VK V+G+G FG VYKG G+ +I VAIK L+ S K
Sbjct: 603 PNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKR-EIYVAIKTLKAGYSEKQ 661
Query: 764 NKEILDEAYVMAGVGSPYVSRLLGICLTST-VQLVTQLMPYGCLLDHVRENRGRLGSQDL 822
++ L EA +M P + RL G+ S V ++T+ M G L +R+N G+ L
Sbjct: 662 RRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQL 721
Query: 823 LNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETE--YHAD 880
+ IA GM YL ++ VHRDLAARN+LV S K++DFGL+R L D ++ Y +
Sbjct: 722 VGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSS 781
Query: 881 -GGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGE 939
GGK+P++W A E+I R+FT SDVWSYG+ +WE+M+FG +PY + +++ + +E+
Sbjct: 782 LGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDY 841
Query: 940 RLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASP 999
RLP P C ++ +M+ CW D RPRF E+V+ +M R+P + P+ P
Sbjct: 842 RLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQP 901
Query: 1000 L 1000
L
Sbjct: 902 L 902
>gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo sapiens]
Length = 1015
Score = 206 bits (525), Expect = 9e-53
Identities = 132/380 (34%), Positives = 203/380 (53%), Gaps = 30/380 (7%)
Query: 655 ISAVVGILLVVVLGVVFGILIKRR------------QQKIRKYTMR-RLLQETELVEPLT 701
+S VG++L L VV G+L+ R ++K+ + +L ++P T
Sbjct: 577 VSVTVGVIL---LAVVIGVLLSGRRCGYSKAKQDPEEEKMHFHNGHIKLPGVRTYIDPHT 633
Query: 702 PSGAMPNQAQMRILKETELRKV---KVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLREN 758
PNQA KE E + +V+G+G FG V G G+ ++PVAIK L+
Sbjct: 634 YED--PNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKR-ELPVAIKTLKVG 690
Query: 759 TSPKANKEILDEAYVMAGVGSPYVSRLLGICLTST-VQLVTQLMPYGCLLDHVRENRGRL 817
+ K ++ L EA +M P + L G+ S V +VT+ M G L +++N G+
Sbjct: 691 YTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQF 750
Query: 818 GSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDID-ETE 876
L+ I+ GM YL D+ VHRDLAARN+L+ S K++DFGL+R+L+ D E
Sbjct: 751 TVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAA 810
Query: 877 YHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLE 936
Y GGK+PI+W A E+I R+FT SDVWSYG+ +WE++++G +PY + +++ +E
Sbjct: 811 YTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVE 870
Query: 937 KGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNED--- 993
+G RLP P C +Y +M+ CW + RP+F E+V+ ++ R+P + N
Sbjct: 871 EGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLIRNPSSLKTLVNASCRV 930
Query: 994 ---LGPASPLDSTFYRSLLE 1010
L SPL S YRS+ E
Sbjct: 931 SNLLAEHSPLGSGAYRSVGE 950
>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
Length = 1074
Score = 206 bits (525), Expect = 9e-53
Identities = 109/277 (39%), Positives = 162/277 (58%), Gaps = 3/277 (1%)
Query: 706 MPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANK 765
MP+ I +E + + +G G FG V++GI++ EN + VAIK + TS +
Sbjct: 431 MPSTRDYEIQRE-RIELGRCIGEGQFGDVHQGIYMSP-ENPALAVAIKTCKNCTSDSVRE 488
Query: 766 EILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNW 825
+ L EA M P++ +L+G+ + V ++ +L G L ++ + L L+ +
Sbjct: 489 KFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILY 548
Query: 826 CMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVP 885
Q++ ++YLE R VHRD+AARNVLV S + VK+ DFGL+R ++ D T Y A GK+P
Sbjct: 549 AYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYME-DSTYYKASKGKLP 607
Query: 886 IKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPP 945
IKWMA ESI RRFT SDVW +GV +WE++ G KP+ G+ ++ +E GERLP PP
Sbjct: 608 IKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPP 667
Query: 946 ICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARD 982
C +Y +M KCW D RPRF EL ++ S + +
Sbjct: 668 NCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEE 704
>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
Length = 1052
Score = 206 bits (525), Expect = 9e-53
Identities = 109/277 (39%), Positives = 162/277 (58%), Gaps = 3/277 (1%)
Query: 706 MPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANK 765
MP+ I +E + + +G G FG V++GI++ EN + VAIK + TS +
Sbjct: 409 MPSTRDYEIQRE-RIELGRCIGEGQFGDVHQGIYMSP-ENPALAVAIKTCKNCTSDSVRE 466
Query: 766 EILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNW 825
+ L EA M P++ +L+G+ + V ++ +L G L ++ + L L+ +
Sbjct: 467 KFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILY 526
Query: 826 CMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVP 885
Q++ ++YLE R VHRD+AARNVLV S + VK+ DFGL+R ++ D T Y A GK+P
Sbjct: 527 AYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYME-DSTYYKASKGKLP 585
Query: 886 IKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPP 945
IKWMA ESI RRFT SDVW +GV +WE++ G KP+ G+ ++ +E GERLP PP
Sbjct: 586 IKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPP 645
Query: 946 ICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARD 982
C +Y +M KCW D RPRF EL ++ S + +
Sbjct: 646 NCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEE 682
>gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 204 bits (520), Expect = 3e-52
Identities = 101/254 (39%), Positives = 160/254 (62%), Gaps = 2/254 (0%)
Query: 724 KVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVS 783
++LG G FG VY+G++ + + KI VA+K +++ + ++ + EA +M + P++
Sbjct: 429 RILGEGFFGEVYEGVYT-NHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIV 487
Query: 784 RLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVH 843
+L+GI ++ +L PYG L ++ N+ L L+ + +QI K M+YLE + VH
Sbjct: 488 KLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVH 547
Query: 844 RDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQS 903
RD+A RN+LV SP VK+ DFGL+R ++ DE Y A ++PIKWM+ ESI RRFT S
Sbjct: 548 RDIAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVTRLPIKWMSPESINFRRFTTAS 606
Query: 904 DVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDS 963
DVW + V +WE+++FG +P+ + +++ +LEKG+RLP+P +C +Y +M +CW D
Sbjct: 607 DVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDP 666
Query: 964 ECRPRFRELVSEFS 977
RPRF ELV S
Sbjct: 667 SDRPRFTELVCSLS 680
>gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo
sapiens]
Length = 967
Score = 204 bits (520), Expect = 3e-52
Identities = 101/254 (39%), Positives = 160/254 (62%), Gaps = 2/254 (0%)
Query: 724 KVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVS 783
++LG G FG VY+G++ + + KI VA+K +++ + ++ + EA +M + P++
Sbjct: 429 RILGEGFFGEVYEGVYT-NHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIV 487
Query: 784 RLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVH 843
+L+GI ++ +L PYG L ++ N+ L L+ + +QI K M+YLE + VH
Sbjct: 488 KLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVH 547
Query: 844 RDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQS 903
RD+A RN+LV SP VK+ DFGL+R ++ DE Y A ++PIKWM+ ESI RRFT S
Sbjct: 548 RDIAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVTRLPIKWMSPESINFRRFTTAS 606
Query: 904 DVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDS 963
DVW + V +WE+++FG +P+ + +++ +LEKG+RLP+P +C +Y +M +CW D
Sbjct: 607 DVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDP 666
Query: 964 ECRPRFRELVSEFS 977
RPRF ELV S
Sbjct: 667 SDRPRFTELVCSLS 680
>gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 204 bits (520), Expect = 3e-52
Identities = 101/254 (39%), Positives = 160/254 (62%), Gaps = 2/254 (0%)
Query: 724 KVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVS 783
++LG G FG VY+G++ + + KI VA+K +++ + ++ + EA +M + P++
Sbjct: 429 RILGEGFFGEVYEGVYT-NHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIV 487
Query: 784 RLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVH 843
+L+GI ++ +L PYG L ++ N+ L L+ + +QI K M+YLE + VH
Sbjct: 488 KLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVH 547
Query: 844 RDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQS 903
RD+A RN+LV SP VK+ DFGL+R ++ DE Y A ++PIKWM+ ESI RRFT S
Sbjct: 548 RDIAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVTRLPIKWMSPESINFRRFTTAS 606
Query: 904 DVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDS 963
DVW + V +WE+++FG +P+ + +++ +LEKG+RLP+P +C +Y +M +CW D
Sbjct: 607 DVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDP 666
Query: 964 ECRPRFRELVSEFS 977
RPRF ELV S
Sbjct: 667 SDRPRFTELVCSLS 680
>gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 204 bits (520), Expect = 3e-52
Identities = 101/254 (39%), Positives = 160/254 (62%), Gaps = 2/254 (0%)
Query: 724 KVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVS 783
++LG G FG VY+G++ + + KI VA+K +++ + ++ + EA +M + P++
Sbjct: 429 RILGEGFFGEVYEGVYT-NHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIV 487
Query: 784 RLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVH 843
+L+GI ++ +L PYG L ++ N+ L L+ + +QI K M+YLE + VH
Sbjct: 488 KLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVH 547
Query: 844 RDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQS 903
RD+A RN+LV SP VK+ DFGL+R ++ DE Y A ++PIKWM+ ESI RRFT S
Sbjct: 548 RDIAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVTRLPIKWMSPESINFRRFTTAS 606
Query: 904 DVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDS 963
DVW + V +WE+++FG +P+ + +++ +LEKG+RLP+P +C +Y +M +CW D
Sbjct: 607 DVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDP 666
Query: 964 ECRPRFRELVSEFS 977
RPRF ELV S
Sbjct: 667 SDRPRFTELVCSLS 680
>gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo sapiens]
Length = 1037
Score = 204 bits (519), Expect = 4e-52
Identities = 118/315 (37%), Positives = 177/315 (56%), Gaps = 12/315 (3%)
Query: 707 PNQAQMRILKETELRKV---KVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKA 763
PNQA KE E + +V+G+G FG V G G+ ++PVAIK L+ + K
Sbjct: 659 PNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKR-ELPVAIKTLKVGYTEKQ 717
Query: 764 NKEILDEAYVMAGVGSPYVSRLLGICLTST-VQLVTQLMPYGCLLDHVRENRGRLGSQDL 822
++ L EA +M P + L G+ S V +VT+ M G L +++N G+ L
Sbjct: 718 RRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQL 777
Query: 823 LNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDID-ETEYHADG 881
+ I+ GM YL D+ VHRDLAARN+L+ S K++DFGL+R+L+ D E Y G
Sbjct: 778 VGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRG 837
Query: 882 GKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERL 941
GK+PI+W A E+I R+FT SDVWSYG+ +WE++++G +PY + +++ +E+G RL
Sbjct: 838 GKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRL 897
Query: 942 PQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNED------LG 995
P P C +Y +M+ CW + RP+F E+V+ ++ R+P + N L
Sbjct: 898 PSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLIRNPSSLKTLVNASCRVSNLLA 957
Query: 996 PASPLDSTFYRSLLE 1010
SPL S YRS+ E
Sbjct: 958 EHSPLGSGAYRSVGE 972
>gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo
sapiens]
Length = 987
Score = 202 bits (515), Expect = 1e-51
Identities = 126/351 (35%), Positives = 192/351 (54%), Gaps = 21/351 (5%)
Query: 651 LTSIISAVVGILLVVVLGVVFGILIKRRQ----------QKIRKYTMRRLLQETEL-VEP 699
L II + L+ ++ VV I+ RR+ K++ YT + ++ ++P
Sbjct: 541 LPLIIGSSAAGLVFLIAVVVIAIVCNRRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDP 600
Query: 700 LTPSGAMPNQAQMRILKETELRKVK---VLGSGAFGTVYKGIWIPDGENVKIPVAIKVLR 756
T PN+A KE ++ VK V+G+G FG V G G+ +I VAIK L+
Sbjct: 601 FTYED--PNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKR-EIFVAIKTLK 657
Query: 757 ENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTST-VQLVTQLMPYGCLLDHVRENRG 815
+ K ++ L EA +M P V L G+ ST V ++T+ M G L +R+N G
Sbjct: 658 SGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDG 717
Query: 816 RLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLD---I 872
+ L+ IA GM YL D+ VHRDLAARN+LV S K++DFGL+R L+
Sbjct: 718 QFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTS 777
Query: 873 DETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIP 932
D T A GGK+PI+W A E+I R+FT SDVWSYG+ +WE+M++G +PY + +++
Sbjct: 778 DPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVI 837
Query: 933 DLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDP 983
+ +E+ RLP P C ++ +M+ CW D RP+F ++V+ +M R+P
Sbjct: 838 NAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNP 888
>gi|4758280 ephrin receptor EphA4 [Homo sapiens]
Length = 986
Score = 202 bits (515), Expect = 1e-51
Identities = 128/365 (35%), Positives = 195/365 (53%), Gaps = 18/365 (4%)
Query: 648 ASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETEL-------VEPL 700
A+ ++S ++LVV+L F +I RR+ K K + +E L V+P
Sbjct: 544 ANSTVLLVSVSGSVVLVVILIAAF--VISRRRSKYSK-AKQEADEEKHLNQGVRTYVDPF 600
Query: 701 TPSGAMPNQAQMRILKETE---LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRE 757
T PNQA KE + ++ KV+G G FG V G G+ +I VAIK L+
Sbjct: 601 TYED--PNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKR-EICVAIKTLKA 657
Query: 758 NTSPKANKEILDEAYVMAGVGSPYVSRLLGICLT-STVQLVTQLMPYGCLLDHVRENRGR 816
+ K ++ L EA +M P + L G+ V ++T+ M G L +R+N GR
Sbjct: 658 GYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGR 717
Query: 817 LGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDID-ET 875
L+ I GM YL D+ VHRDLAARN+LV S K++DFG++R+L+ D E
Sbjct: 718 FTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEA 777
Query: 876 EYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLL 935
Y GGK+PI+W A E+I R+FT SDVWSYG+ +WE+M++G +PY + +++ +
Sbjct: 778 AYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAI 837
Query: 936 EKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLG 995
E+G RLP P C I ++ +M+ CW + RP+F ++V+ ++ R+P E
Sbjct: 838 EEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGTESSR 897
Query: 996 PASPL 1000
P + L
Sbjct: 898 PNTAL 902
>gi|17975768 ephrin receptor EphB3 precursor [Homo sapiens]
Length = 998
Score = 202 bits (515), Expect = 1e-51
Identities = 130/395 (32%), Positives = 207/395 (52%), Gaps = 16/395 (4%)
Query: 639 DKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQE----- 693
++G A+Q L I+ + L+ VV VV I+ R+Q+ LQ+
Sbjct: 545 ERGSGAQQLQEQLPLIVGSATAGLVFVVAVVVIAIVCLRKQRHGSDSEYTEKLQQYIAPG 604
Query: 694 -TELVEPLTPSGAMPNQAQMRILKETELRKVK---VLGSGAFGTVYKGIWIPDGENVKIP 749
++P T PN+A KE ++ VK V+G+G FG V +G G ++
Sbjct: 605 MKVYIDPFTYED--PNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRR-EVF 661
Query: 750 VAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTST-VQLVTQLMPYGCLLD 808
VAIK L+ + + ++ L EA +M P + RL G+ S V ++T+ M L
Sbjct: 662 VAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDS 721
Query: 809 HVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLAR 868
+R N G+ L+ IA GM YL ++ VHRDLAARN+LV S K++DFGL+R
Sbjct: 722 FLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSR 781
Query: 869 LLDIDETE--YHAD-GGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDG 925
L+ D ++ Y + GGK+PI+W A E+I R+FT SDVWSYG+ +WE+M++G +PY
Sbjct: 782 FLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWD 841
Query: 926 IPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQR 985
+ +++ + +E+ RLP P C ++ +M+ CW+ D RP+F ++V+ ++ R+
Sbjct: 842 MSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLIRNAAS 901
Query: 986 FVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDA 1020
VI + G + PL +GD +DA
Sbjct: 902 LKVIASAQSGMSQPLLDRTVPDYTTFTTVGDWLDA 936
>gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo
sapiens]
Length = 986
Score = 202 bits (514), Expect = 2e-51
Identities = 126/350 (36%), Positives = 191/350 (54%), Gaps = 20/350 (5%)
Query: 651 LTSIISAVVGILLVVVLGVVFGILIKRR---------QQKIRKYTMRRLLQETEL-VEPL 700
L II + L+ ++ VV I+ RR K++ YT + ++ ++P
Sbjct: 541 LPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPF 600
Query: 701 TPSGAMPNQAQMRILKETELRKVK---VLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRE 757
T PN+A KE ++ VK V+G+G FG V G G+ +I VAIK L+
Sbjct: 601 TYED--PNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKR-EIFVAIKTLKS 657
Query: 758 NTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTST-VQLVTQLMPYGCLLDHVRENRGR 816
+ K ++ L EA +M P V L G+ ST V ++T+ M G L +R+N G+
Sbjct: 658 GYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQ 717
Query: 817 LGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLD---ID 873
L+ IA GM YL D+ VHRDLAARN+LV S K++DFGL+R L+ D
Sbjct: 718 FTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSD 777
Query: 874 ETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPD 933
T A GGK+PI+W A E+I R+FT SDVWSYG+ +WE+M++G +PY + +++ +
Sbjct: 778 PTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVIN 837
Query: 934 LLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDP 983
+E+ RLP P C ++ +M+ CW D RP+F ++V+ +M R+P
Sbjct: 838 AIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNP 887
>gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo
sapiens]
Length = 1038
Score = 201 bits (511), Expect = 4e-51
Identities = 111/276 (40%), Positives = 167/276 (60%), Gaps = 7/276 (2%)
Query: 699 PLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIW-IPDGENVKIPVAIKVLRE 757
P P+G P Q+ ++ E +LR ++ LG G+FG V +G W P G+ V VA+K L+
Sbjct: 105 PGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVS--VAVKCLKP 162
Query: 758 N--TSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRG 815
+ + P+A + + E M + + RL G+ LT +++VT+L P G LLD +R+++G
Sbjct: 163 DVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQG 222
Query: 816 RLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDET 875
L + +Q+A+GM YLE R +HRDLAARN+L+ + + VKI DFGL R L ++
Sbjct: 223 HFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDD 282
Query: 876 EY-HADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDL 934
Y + KVP W A ES+ R F+H SD W +GVT+WE+ T+G +P+ G+ +I
Sbjct: 283 HYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHK 342
Query: 935 LEK-GERLPQPPICTIDVYMIMVKCWMIDSECRPRF 969
++K GERLP+P C D+Y +MV+CW E RP F
Sbjct: 343 IDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTF 378
Score = 39.7 bits (91), Expect = 0.018
Identities = 44/156 (28%), Positives = 59/156 (37%), Gaps = 24/156 (15%)
Query: 1077 PSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSED------PTVPLPSE-TDGYVA 1129
PS +++F L + LQ+ P P+P D P VP+P T +V
Sbjct: 698 PSSAQTAEIFQA-LQQECMRQLQA-PAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQ 755
Query: 1130 PLTCSPQPEYVNQ-------PDVRPQPPSPREG---PLPAARPAGATLERPKTLSPGKNG 1179
P E +Q P V P+ P +G P P P + L + SPGK
Sbjct: 756 LSPAPPGEEETSQWPGPASPPRVPPREPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTM 815
Query: 1180 VVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSP 1215
FA +P+Y TPQ AP P P P
Sbjct: 816 PTTQSFA-----SDPKYATPQVIQAPGPRAGPCILP 846
Score = 32.3 bits (72), Expect = 2.9
Identities = 35/124 (28%), Positives = 46/124 (37%), Gaps = 33/124 (26%)
Query: 1134 SPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVEN 1193
SP P ++P V P+ P P P + LSP G ++ + G
Sbjct: 728 SPSPGGDDKPQVPPRVPIPPRPTRPHVQ-----------LSPAPPGE-EETSQWPGPASP 775
Query: 1194 P-----EYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPT----AE 1244
P E L+PQG P P PP SP PP + P K PT A
Sbjct: 776 PRVPPREPLSPQGSRTPSPLVPPGSSPL----------PPRLSSSPG--KTMPTTQSFAS 823
Query: 1245 NPEY 1248
+P+Y
Sbjct: 824 DPKY 827
>gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo
sapiens]
Length = 1086
Score = 201 bits (511), Expect = 4e-51
Identities = 111/276 (40%), Positives = 167/276 (60%), Gaps = 7/276 (2%)
Query: 699 PLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIW-IPDGENVKIPVAIKVLRE 757
P P+G P Q+ ++ E +LR ++ LG G+FG V +G W P G+ V VA+K L+
Sbjct: 168 PGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVS--VAVKCLKP 225
Query: 758 N--TSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRG 815
+ + P+A + + E M + + RL G+ LT +++VT+L P G LLD +R+++G
Sbjct: 226 DVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQG 285
Query: 816 RLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDET 875
L + +Q+A+GM YLE R +HRDLAARN+L+ + + VKI DFGL R L ++
Sbjct: 286 HFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDD 345
Query: 876 EY-HADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDL 934
Y + KVP W A ES+ R F+H SD W +GVT+WE+ T+G +P+ G+ +I
Sbjct: 346 HYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHK 405
Query: 935 LEK-GERLPQPPICTIDVYMIMVKCWMIDSECRPRF 969
++K GERLP+P C D+Y +MV+CW E RP F
Sbjct: 406 IDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTF 441
Score = 39.7 bits (91), Expect = 0.018
Identities = 44/156 (28%), Positives = 59/156 (37%), Gaps = 24/156 (15%)
Query: 1077 PSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSED------PTVPLPSE-TDGYVA 1129
PS +++F L + LQ+ P P+P D P VP+P T +V
Sbjct: 776 PSSAQTAEIFQA-LQQECMRQLQA-PAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQ 833
Query: 1130 PLTCSPQPEYVNQ-------PDVRPQPPSPREG---PLPAARPAGATLERPKTLSPGKNG 1179
P E +Q P V P+ P +G P P P + L + SPGK
Sbjct: 834 LSPAPPGEEETSQWPGPASPPRVPPREPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTM 893
Query: 1180 VVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSP 1215
FA +P+Y TPQ AP P P P
Sbjct: 894 PTTQSFA-----SDPKYATPQVIQAPGPRAGPCILP 924
Score = 32.3 bits (72), Expect = 2.9
Identities = 35/124 (28%), Positives = 46/124 (37%), Gaps = 33/124 (26%)
Query: 1134 SPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVEN 1193
SP P ++P V P+ P P P + LSP G ++ + G
Sbjct: 806 SPSPGGDDKPQVPPRVPIPPRPTRPHVQ-----------LSPAPPGE-EETSQWPGPASP 853
Query: 1194 P-----EYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPT----AE 1244
P E L+PQG P P PP SP PP + P K PT A
Sbjct: 854 PRVPPREPLSPQGSRTPSPLVPPGSSPL----------PPRLSSSPG--KTMPTTQSFAS 901
Query: 1245 NPEY 1248
+P+Y
Sbjct: 902 DPKY 905
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 201 bits (510), Expect = 5e-51
Identities = 120/290 (41%), Positives = 163/290 (56%), Gaps = 10/290 (3%)
Query: 715 LKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVM 774
++ T++ LG G +G VY G+W + + VA+K L+E+T +E L EA VM
Sbjct: 268 MERTDITMKHKLGGGQYGEVYVGVW----KKYSLTVAVKTLKEDTMEV--EEFLKEAAVM 321
Query: 775 AGVGSPYVSRLLGIC-LTSTVQLVTQLMPYGCLLDHVRE-NRGRLGSQDLLNWCMQIAKG 832
+ P + +LLG+C L +VT+ MPYG LLD++RE NR + + LL QI+
Sbjct: 322 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 381
Query: 833 MSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALE 892
M YLE +HRDLAARN LV + VK+ DFGL+RL+ D HA G K PIKW A E
Sbjct: 382 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHA-GAKFPIKWTAPE 440
Query: 893 SILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVY 952
S+ F+ +SDVW++GV +WE+ T+G PY GI ++ DLLEKG R+ QP C VY
Sbjct: 441 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 500
Query: 953 MIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDS 1002
+M CW RP F E F M D + E+LG A+ S
Sbjct: 501 ELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVA-EELGRAASSSS 549
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 201 bits (510), Expect = 5e-51
Identities = 120/290 (41%), Positives = 163/290 (56%), Gaps = 10/290 (3%)
Query: 715 LKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVM 774
++ T++ LG G +G VY G+W + + VA+K L+E+T +E L EA VM
Sbjct: 283 MERTDITMKHKLGGGQYGEVYVGVW----KKYSLTVAVKTLKEDTMEV--EEFLKEAAVM 336
Query: 775 AGVGSPYVSRLLGIC-LTSTVQLVTQLMPYGCLLDHVRE-NRGRLGSQDLLNWCMQIAKG 832
+ P + +LLG+C L +VT+ MPYG LLD++RE NR + + LL QI+
Sbjct: 337 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 396
Query: 833 MSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALE 892
M YLE +HRDLAARN LV + VK+ DFGL+RL+ D HA G K PIKW A E
Sbjct: 397 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHA-GAKFPIKWTAPE 455
Query: 893 SILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVY 952
S+ F+ +SDVW++GV +WE+ T+G PY GI ++ DLLEKG R+ QP C VY
Sbjct: 456 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 515
Query: 953 MIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDS 1002
+M CW RP F E F M D + E+LG A+ S
Sbjct: 516 ELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVA-EELGRAASSSS 564
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 201 bits (510), Expect = 5e-51
Identities = 120/290 (41%), Positives = 163/290 (56%), Gaps = 10/290 (3%)
Query: 715 LKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVM 774
++ T++ LG G +G VY G+W + + VA+K L+E+T +E L EA VM
Sbjct: 268 MERTDITMKHKLGGGQYGEVYVGVW----KKYSLTVAVKTLKEDTMEV--EEFLKEAAVM 321
Query: 775 AGVGSPYVSRLLGIC-LTSTVQLVTQLMPYGCLLDHVRE-NRGRLGSQDLLNWCMQIAKG 832
+ P + +LLG+C L +VT+ MPYG LLD++RE NR + + LL QI+
Sbjct: 322 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 381
Query: 833 MSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALE 892
M YLE +HRDLAARN LV + VK+ DFGL+RL+ D HA G K PIKW A E
Sbjct: 382 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHA-GAKFPIKWTAPE 440
Query: 893 SILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVY 952
S+ F+ +SDVW++GV +WE+ T+G PY GI ++ DLLEKG R+ QP C VY
Sbjct: 441 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 500
Query: 953 MIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDS 1002
+M CW RP F E F M D + E+LG A+ S
Sbjct: 501 ELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVA-EELGRAASSSS 549
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 201 bits (510), Expect = 5e-51
Identities = 120/290 (41%), Positives = 163/290 (56%), Gaps = 10/290 (3%)
Query: 715 LKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVM 774
++ T++ LG G +G VY G+W + + VA+K L+E+T +E L EA VM
Sbjct: 247 MERTDITMKHKLGGGQYGEVYVGVW----KKYSLTVAVKTLKEDTMEV--EEFLKEAAVM 300
Query: 775 AGVGSPYVSRLLGIC-LTSTVQLVTQLMPYGCLLDHVRE-NRGRLGSQDLLNWCMQIAKG 832
+ P + +LLG+C L +VT+ MPYG LLD++RE NR + + LL QI+
Sbjct: 301 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 360
Query: 833 MSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALE 892
M YLE +HRDLAARN LV + VK+ DFGL+RL+ D HA G K PIKW A E
Sbjct: 361 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHA-GAKFPIKWTAPE 419
Query: 893 SILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVY 952
S+ F+ +SDVW++GV +WE+ T+G PY GI ++ DLLEKG R+ QP C VY
Sbjct: 420 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 479
Query: 953 MIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDS 1002
+M CW RP F E F M D + E+LG A+ S
Sbjct: 480 ELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVA-EELGRAASSSS 528
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.441
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,219,438
Number of Sequences: 37866
Number of extensions: 3420812
Number of successful extensions: 15539
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 580
Number of HSP's successfully gapped in prelim test: 678
Number of HSP's that attempted gapping in prelim test: 11689
Number of HSP's gapped (non-prelim): 3068
length of query: 1255
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1141
effective length of database: 13,930,794
effective search space: 15895035954
effective search space used: 15895035954
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.