Guide to the Human Genome
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Search of human proteins with 51173727

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|51173727 Sma- and Mad-related protein 1 [Homo sapiens]
         (465 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|51173727 Sma- and Mad-related protein 1 [Homo sapiens]             991   0.0  
gi|5174509 Sma- and Mad-related protein 1 [Homo sapiens]              991   0.0  
gi|47778931 SMAD, mothers against DPP homolog 5 [Homo sapiens]        875   0.0  
gi|47778929 SMAD, mothers against DPP homolog 5 [Homo sapiens]        875   0.0  
gi|47778925 SMAD, mothers against DPP homolog 5 [Homo sapiens]        875   0.0  
gi|187828357 SMAD family member 9 isoform a [Homo sapiens]            783   0.0  
gi|5174519 SMAD family member 9 isoform b [Homo sapiens]              749   0.0  
gi|5174513 mothers against decapentaplegic homolog 3 isoform 1 [...   555   e-158
gi|209693426 Sma- and Mad-related protein 2 isoform 2 [Homo sapi...   551   e-157
gi|51173730 Sma- and Mad-related protein 2 isoform 1 [Homo sapiens]   536   e-152
gi|5174511 Sma- and Mad-related protein 2 isoform 1 [Homo sapiens]    536   e-152
gi|223029442 mothers against decapentaplegic homolog 3 isoform 3...   484   e-137
gi|223029440 mothers against decapentaplegic homolog 3 isoform 2...   409   e-114
gi|223029444 mothers against decapentaplegic homolog 3 isoform 4...   343   1e-94
gi|4885457 mothers against decapentaplegic homolog 4 [Homo sapiens]   265   7e-71
gi|218749837 SMAD family member 6 isoform 2 [Homo sapiens]             96   9e-20
gi|92859871 SMAD family member 6 isoform 1 [Homo sapiens]              95   2e-19
gi|5174517 SMAD family member 7 [Homo sapiens]                         92   8e-19
gi|4557317 annexin A11 [Homo sapiens]                                  51   3e-06
gi|22165433 annexin A11 [Homo sapiens]                                 51   3e-06
gi|22165431 annexin A11 [Homo sapiens]                                 51   3e-06
gi|167555104 interferon regulatory factor 4 [Homo sapiens]             45   2e-04
gi|32307128 nuclear receptor coactivator 6 [Homo sapiens]              44   2e-04
gi|118498345 AT-binding transcription factor 1 [Homo sapiens]          44   4e-04
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    43   5e-04
gi|209862789 microtubule associated monoxygenase, calponin and L...    43   5e-04
gi|42544123 splicing factor 1 isoform 3 [Homo sapiens]                 42   0.001
gi|42544125 splicing factor 1 isoform 2 [Homo sapiens]                 42   0.001
gi|42544130 splicing factor 1 isoform 1 [Homo sapiens]                 42   0.001
gi|32699048 family with sequence similarity 70, member B [Homo s...    41   0.003

>gi|51173727 Sma- and Mad-related protein 1 [Homo sapiens]
          Length = 465

 Score =  991 bits (2561), Expect = 0.0
 Identities = 465/465 (100%), Positives = 465/465 (100%)

Query: 1   MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQ 60
           MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQ
Sbjct: 1   MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQ 60

Query: 61  PSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEV 120
           PSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEV
Sbjct: 61  PSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEV 120

Query: 121 CINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPN 180
           CINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPN
Sbjct: 121 CINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPN 180

Query: 181 SHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQ 240
           SHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQ
Sbjct: 181 SHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQ 240

Query: 241 PMDTNMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT 300
           PMDTNMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT
Sbjct: 241 PMDTNMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT 300

Query: 301 DPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC 360
           DPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC
Sbjct: 301 DPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC 360

Query: 361 NYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGW 420
           NYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGW
Sbjct: 361 NYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGW 420

Query: 421 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS 465
           GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
Sbjct: 421 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS 465


>gi|5174509 Sma- and Mad-related protein 1 [Homo sapiens]
          Length = 465

 Score =  991 bits (2561), Expect = 0.0
 Identities = 465/465 (100%), Positives = 465/465 (100%)

Query: 1   MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQ 60
           MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQ
Sbjct: 1   MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQ 60

Query: 61  PSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEV 120
           PSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEV
Sbjct: 61  PSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEV 120

Query: 121 CINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPN 180
           CINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPN
Sbjct: 121 CINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPN 180

Query: 181 SHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQ 240
           SHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQ
Sbjct: 181 SHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQ 240

Query: 241 PMDTNMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT 300
           PMDTNMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT
Sbjct: 241 PMDTNMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT 300

Query: 301 DPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC 360
           DPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC
Sbjct: 301 DPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC 360

Query: 361 NYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGW 420
           NYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGW
Sbjct: 361 NYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGW 420

Query: 421 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS 465
           GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
Sbjct: 421 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS 465


>gi|47778931 SMAD, mothers against DPP homolog 5 [Homo sapiens]
          Length = 465

 Score =  875 bits (2262), Expect = 0.0
 Identities = 417/465 (89%), Positives = 432/465 (92%), Gaps = 3/465 (0%)

Query: 2   NVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQP 61
           ++ SLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALS PGQP
Sbjct: 3   SMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPGQP 62

Query: 62  SNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVC 121
           S CVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPL+ CEFPFGSKQKEVC
Sbjct: 63  SKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVC 122

Query: 122 INPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPNS 181
           INPYHYKRVESPVLPPVLVPRH+E+NPQHSLL QFRNL  NEPHMP NATFPDSF QPN+
Sbjct: 123 INPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNN 182

Query: 182 HPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQP 241
            PFP SPNS YP SP  +SSTYP+SP SS PGSPFQ+PADTPPPAY+PP+D M QD SQP
Sbjct: 183 TPFPLSPNSPYPPSP--ASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNSQP 240

Query: 242 MDT-NMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT 300
           MDT N M P +   I+  DVQ VAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT
Sbjct: 241 MDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT 300

Query: 301 DPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC 360
           DPSNNK+RFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC
Sbjct: 301 DPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC 360

Query: 361 NYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGW 420
           N+HHGFHPTTVCKIPS CSLKIFNNQEFAQLLAQSVNHGFE VYELTKMCTIRMSFVKGW
Sbjct: 361 NFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGW 420

Query: 421 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS 465
           GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSP NPISSVS
Sbjct: 421 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS 465


>gi|47778929 SMAD, mothers against DPP homolog 5 [Homo sapiens]
          Length = 465

 Score =  875 bits (2262), Expect = 0.0
 Identities = 417/465 (89%), Positives = 432/465 (92%), Gaps = 3/465 (0%)

Query: 2   NVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQP 61
           ++ SLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALS PGQP
Sbjct: 3   SMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPGQP 62

Query: 62  SNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVC 121
           S CVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPL+ CEFPFGSKQKEVC
Sbjct: 63  SKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVC 122

Query: 122 INPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPNS 181
           INPYHYKRVESPVLPPVLVPRH+E+NPQHSLL QFRNL  NEPHMP NATFPDSF QPN+
Sbjct: 123 INPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNN 182

Query: 182 HPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQP 241
            PFP SPNS YP SP  +SSTYP+SP SS PGSPFQ+PADTPPPAY+PP+D M QD SQP
Sbjct: 183 TPFPLSPNSPYPPSP--ASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNSQP 240

Query: 242 MDT-NMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT 300
           MDT N M P +   I+  DVQ VAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT
Sbjct: 241 MDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT 300

Query: 301 DPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC 360
           DPSNNK+RFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC
Sbjct: 301 DPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC 360

Query: 361 NYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGW 420
           N+HHGFHPTTVCKIPS CSLKIFNNQEFAQLLAQSVNHGFE VYELTKMCTIRMSFVKGW
Sbjct: 361 NFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGW 420

Query: 421 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS 465
           GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSP NPISSVS
Sbjct: 421 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS 465


>gi|47778925 SMAD, mothers against DPP homolog 5 [Homo sapiens]
          Length = 465

 Score =  875 bits (2262), Expect = 0.0
 Identities = 417/465 (89%), Positives = 432/465 (92%), Gaps = 3/465 (0%)

Query: 2   NVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQP 61
           ++ SLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALS PGQP
Sbjct: 3   SMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPGQP 62

Query: 62  SNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVC 121
           S CVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPL+ CEFPFGSKQKEVC
Sbjct: 63  SKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVC 122

Query: 122 INPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPNS 181
           INPYHYKRVESPVLPPVLVPRH+E+NPQHSLL QFRNL  NEPHMP NATFPDSF QPN+
Sbjct: 123 INPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNN 182

Query: 182 HPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQP 241
            PFP SPNS YP SP  +SSTYP+SP SS PGSPFQ+PADTPPPAY+PP+D M QD SQP
Sbjct: 183 TPFPLSPNSPYPPSP--ASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNSQP 240

Query: 242 MDT-NMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT 300
           MDT N M P +   I+  DVQ VAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT
Sbjct: 241 MDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT 300

Query: 301 DPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC 360
           DPSNNK+RFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC
Sbjct: 301 DPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC 360

Query: 361 NYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGW 420
           N+HHGFHPTTVCKIPS CSLKIFNNQEFAQLLAQSVNHGFE VYELTKMCTIRMSFVKGW
Sbjct: 361 NFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGW 420

Query: 421 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS 465
           GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSP NPISSVS
Sbjct: 421 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS 465


>gi|187828357 SMAD family member 9 isoform a [Homo sapiens]
          Length = 467

 Score =  783 bits (2021), Expect = 0.0
 Identities = 379/465 (81%), Positives = 407/465 (87%), Gaps = 6/465 (1%)

Query: 3   VTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQPS 62
           ++SLFSFTSPAVKRLLGWKQGDEEEKWAEKAVD+LVKKLKKKKGAM+ELE+ALSCPGQPS
Sbjct: 7   ISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALSCPGQPS 66

Query: 63  NCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCI 122
            CVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCI
Sbjct: 67  KCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCI 126

Query: 123 NPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLG-QNEPHMPLNATFPDSFQQPNS 181
           NPYHY+RVE+PVLPPVLVPRHSEYNPQ SLLA+FR+    +EP MP NAT+PDSFQQP  
Sbjct: 127 NPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDSFQQPPC 186

Query: 182 HPFPHSPNSSYPNSPGSSSSTYPHSPTS-SDPGSPFQMPADTPPPAYLPPEDPMTQDGSQ 240
              P SP+ ++  SP ++S  YPHSP S S+P SP+Q   DTPP  Y   E   TQ G Q
Sbjct: 187 SALPPSPSHAFSQSPCTAS--YPHSPGSPSEPESPYQHSVDTPPLPYHATEASETQSG-Q 243

Query: 241 PMDTNMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT 300
           P+D       + S I  GD + V YEEP+HWCS+ YYELNNRVGE F ASS SVL+DGFT
Sbjct: 244 PVDATADRHVVLS-IPNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDGFT 302

Query: 301 DPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC 360
           DPSNN+NRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAEC+SDSSIFVQSRNC
Sbjct: 303 DPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSRNC 362

Query: 361 NYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGW 420
           NY HGFHP TVCKIPSGCSLK+FNNQ FAQLLAQSV+HGFE VYELTKMCTIRMSFVKGW
Sbjct: 363 NYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVKGW 422

Query: 421 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS 465
           GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
Sbjct: 423 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS 467


>gi|5174519 SMAD family member 9 isoform b [Homo sapiens]
          Length = 430

 Score =  749 bits (1933), Expect = 0.0
 Identities = 364/464 (78%), Positives = 389/464 (83%), Gaps = 41/464 (8%)

Query: 3   VTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQPS 62
           ++SLFSFTSPAVKRLLGWKQGDEEEKWAEKAVD+LVKKLKKKKGAM+ELE+ALSCPGQPS
Sbjct: 7   ISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALSCPGQPS 66

Query: 63  NCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCI 122
            CVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCI
Sbjct: 67  KCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCI 126

Query: 123 NPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLG-QNEPHMPLNATFPDSFQQPNS 181
           NPYHY+RVE+PVLPPVLVPRHSEYNPQ SLLA+FR+    +EP MP NAT+PDSFQQP  
Sbjct: 127 NPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDSFQQPPC 186

Query: 182 HPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQP 241
              P SP+ ++  SP ++S  YPHSP     GSP +            PE P        
Sbjct: 187 SALPPSPSHAFSQSPCTAS--YPHSP-----GSPSE------------PESPY------- 220

Query: 242 MDTNMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTD 301
                            D + V YEEP+HWCS+ YYELNNRVGE F ASS SVL+DGFTD
Sbjct: 221 --------------QHSDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDGFTD 266

Query: 302 PSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCN 361
           PSNN+NRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAEC+SDSSIFVQSRNCN
Sbjct: 267 PSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSRNCN 326

Query: 362 YHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWG 421
           Y HGFHP TVCKIPSGCSLK+FNNQ FAQLLAQSV+HGFE VYELTKMCTIRMSFVKGWG
Sbjct: 327 YQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVKGWG 386

Query: 422 AEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS 465
           AEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
Sbjct: 387 AEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS 430


>gi|5174513 mothers against decapentaplegic homolog 3 isoform 1
           [Homo sapiens]
          Length = 425

 Score =  555 bits (1431), Expect = e-158
 Identities = 286/471 (60%), Positives = 333/471 (70%), Gaps = 54/471 (11%)

Query: 3   VTSLFSFTSPAVKRLLGWKQGDE---EEKWAEKAVDALVKKLKKKKGAMEELEKALSCPG 59
           ++S+  FT P VKRLLGWK+G++   EEKW EKAV +LVKKLKK  G ++ELEKA++   
Sbjct: 1   MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKT-GQLDELEKAITTQN 59

Query: 60  QPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKE 119
             + C+TIPRSLDGRLQVSHRKGLPHVIYCR+WRWPDL SHHEL+ +E CEF F  K+ E
Sbjct: 60  VNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDE 119

Query: 120 VCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQP 179
           VC+NPYHY+RVE+PVLPPVLVPRH+E      + A+F  L      +P N  FP   +  
Sbjct: 120 VCVNPYHYQRVETPVLPPVLVPRHTE------IPAEFPPLDDYSHSIPENTNFPAGIE-- 171

Query: 180 NSHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDG- 238
                   P S+ P                           +TPPP YL  ED  T D  
Sbjct: 172 --------PQSNIP---------------------------ETPPPGYLS-EDGETSDHQ 195

Query: 239 -SQPMDT---NMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSV 294
            +  MD    N+   P+    N  D+Q V Y EP  WCSI YYELN RVGE FHAS  S+
Sbjct: 196 MNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSM 255

Query: 295 LVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIF 354
            VDGFTDPSN++ RFCLGLLSNVNRN+ +E TRRHIG+GV LYY+GGEV+AECLSDS+IF
Sbjct: 256 TVDGFTDPSNSE-RFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIF 314

Query: 355 VQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRM 414
           VQS NCN  +G+HP TVCKIP GC+LKIFNNQEFA LLAQSVN GFE VY+LT+MCTIRM
Sbjct: 315 VQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRM 374

Query: 415 SFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS 465
           SFVKGWGAEY RQ VTSTPCWIE+HL+GPLQWLDKVLTQMGSP    SSVS
Sbjct: 375 SFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS 425


>gi|209693426 Sma- and Mad-related protein 2 isoform 2 [Homo
           sapiens]
          Length = 437

 Score =  551 bits (1421), Expect = e-157
 Identities = 288/482 (59%), Positives = 336/482 (69%), Gaps = 64/482 (13%)

Query: 3   VTSLFSFTSPAVKRLLGWK-------------QGDEEEKWAEKAVDALVKKLKKKKGAME 49
           ++S+  FT P VKRLLGWK             Q  +EEKW EKAV +LVKKLKK  G ++
Sbjct: 1   MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKT-GRLD 59

Query: 50  ELEKALSCPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECC 109
           ELEKA++     + CVTIPRSLDGRLQVSHRKGLPHVIYCR+WRWPDL SHHELK +E C
Sbjct: 60  ELEKAITTQNCNTKCVTIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENC 119

Query: 110 EFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLN 169
           E+ F  K+ EVC+NPYHY+RVE+PVLPPVLVPRH+E      +L +   L      +P N
Sbjct: 120 EYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTE------ILTELPPLDDYTHSIPEN 173

Query: 170 ATFPDSFQQPNSHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLP 229
             FP   +          P S+Y                         +P +TPPP Y+ 
Sbjct: 174 TNFPAGIE----------PQSNY-------------------------IP-ETPPPGYIS 197

Query: 230 PEDPMTQDG--SQPMDTNM---MAPPLPSEINRG-DVQAVAYEEPKHWCSIVYYELNNRV 283
            ED  T D   +Q MDT     ++P   S +N   D+Q V Y EP  WCSI YYELN RV
Sbjct: 198 -EDGETSDQQLNQSMDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRV 256

Query: 284 GEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEV 343
           GE FHAS  S+ VDGFTDPSN++ RFCLGLLSNVNRN+T+E TRRHIG+GV LYY+GGEV
Sbjct: 257 GETFHASQPSLTVDGFTDPSNSE-RFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEV 315

Query: 344 YAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETV 403
           +AECLSDS+IFVQS NCN  +G+HP TVCKIP GC+LKIFNNQEFA LLAQSVN GFE V
Sbjct: 316 FAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAV 375

Query: 404 YELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISS 463
           Y+LT+MCTIRMSFVKGWGAEY RQ VTSTPCWIE+HL+GPLQWLDKVLTQMGSP    SS
Sbjct: 376 YQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSS 435

Query: 464 VS 465
           +S
Sbjct: 436 MS 437


>gi|51173730 Sma- and Mad-related protein 2 isoform 1 [Homo sapiens]
          Length = 467

 Score =  536 bits (1380), Expect = e-152
 Identities = 288/512 (56%), Positives = 336/512 (65%), Gaps = 94/512 (18%)

Query: 3   VTSLFSFTSPAVKRLLGWK-------------QGDEEEKWAEKAVDALVKKLKKKKGAME 49
           ++S+  FT P VKRLLGWK             Q  +EEKW EKAV +LVKKLKK  G ++
Sbjct: 1   MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKT-GRLD 59

Query: 50  ELEKALSCPGQPSNCVTIP------------------------------RSLDGRLQVSH 79
           ELEKA++     + CVTIP                              RSLDGRLQVSH
Sbjct: 60  ELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSH 119

Query: 80  RKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYKRVESPVLPPVL 139
           RKGLPHVIYCR+WRWPDL SHHELK +E CE+ F  K+ EVC+NPYHY+RVE+PVLPPVL
Sbjct: 120 RKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVL 179

Query: 140 VPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNSPGSS 199
           VPRH+E      +L +   L      +P N  FP   +          P S+Y       
Sbjct: 180 VPRHTE------ILTELPPLDDYTHSIPENTNFPAGIE----------PQSNY------- 216

Query: 200 SSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDG--SQPMDTNM---MAPPLPSE 254
                             +P +TPPP Y+  ED  T D   +Q MDT     ++P   S 
Sbjct: 217 ------------------IP-ETPPPGYIS-EDGETSDQQLNQSMDTGSPAELSPTTLSP 256

Query: 255 INRG-DVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGL 313
           +N   D+Q V Y EP  WCSI YYELN RVGE FHAS  S+ VDGFTDPSN++ RFCLGL
Sbjct: 257 VNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSE-RFCLGL 315

Query: 314 LSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCK 373
           LSNVNRN+T+E TRRHIG+GV LYY+GGEV+AECLSDS+IFVQS NCN  +G+HP TVCK
Sbjct: 316 LSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCK 375

Query: 374 IPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTP 433
           IP GC+LKIFNNQEFA LLAQSVN GFE VY+LT+MCTIRMSFVKGWGAEY RQ VTSTP
Sbjct: 376 IPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTP 435

Query: 434 CWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS 465
           CWIE+HL+GPLQWLDKVLTQMGSP    SS+S
Sbjct: 436 CWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS 467


>gi|5174511 Sma- and Mad-related protein 2 isoform 1 [Homo sapiens]
          Length = 467

 Score =  536 bits (1380), Expect = e-152
 Identities = 288/512 (56%), Positives = 336/512 (65%), Gaps = 94/512 (18%)

Query: 3   VTSLFSFTSPAVKRLLGWK-------------QGDEEEKWAEKAVDALVKKLKKKKGAME 49
           ++S+  FT P VKRLLGWK             Q  +EEKW EKAV +LVKKLKK  G ++
Sbjct: 1   MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKT-GRLD 59

Query: 50  ELEKALSCPGQPSNCVTIP------------------------------RSLDGRLQVSH 79
           ELEKA++     + CVTIP                              RSLDGRLQVSH
Sbjct: 60  ELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSH 119

Query: 80  RKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYKRVESPVLPPVL 139
           RKGLPHVIYCR+WRWPDL SHHELK +E CE+ F  K+ EVC+NPYHY+RVE+PVLPPVL
Sbjct: 120 RKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVL 179

Query: 140 VPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNSPGSS 199
           VPRH+E      +L +   L      +P N  FP   +          P S+Y       
Sbjct: 180 VPRHTE------ILTELPPLDDYTHSIPENTNFPAGIE----------PQSNY------- 216

Query: 200 SSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDG--SQPMDTNM---MAPPLPSE 254
                             +P +TPPP Y+  ED  T D   +Q MDT     ++P   S 
Sbjct: 217 ------------------IP-ETPPPGYIS-EDGETSDQQLNQSMDTGSPAELSPTTLSP 256

Query: 255 INRG-DVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGL 313
           +N   D+Q V Y EP  WCSI YYELN RVGE FHAS  S+ VDGFTDPSN++ RFCLGL
Sbjct: 257 VNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSE-RFCLGL 315

Query: 314 LSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCK 373
           LSNVNRN+T+E TRRHIG+GV LYY+GGEV+AECLSDS+IFVQS NCN  +G+HP TVCK
Sbjct: 316 LSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCK 375

Query: 374 IPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTP 433
           IP GC+LKIFNNQEFA LLAQSVN GFE VY+LT+MCTIRMSFVKGWGAEY RQ VTSTP
Sbjct: 376 IPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTP 435

Query: 434 CWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS 465
           CWIE+HL+GPLQWLDKVLTQMGSP    SS+S
Sbjct: 436 CWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS 467


>gi|223029442 mothers against decapentaplegic homolog 3 isoform 3
           [Homo sapiens]
          Length = 381

 Score =  484 bits (1246), Expect = e-137
 Identities = 248/402 (61%), Positives = 282/402 (70%), Gaps = 50/402 (12%)

Query: 69  RSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYK 128
           RSLDGRLQVSHRKGLPHVIYCR+WRWPDL SHHEL+ +E CEF F  K+ EVC+NPYHY+
Sbjct: 25  RSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQ 84

Query: 129 RVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPNSHPFPHSP 188
           RVE+PVLPPVLVPRH+E      + A+F  L      +P N  FP   +          P
Sbjct: 85  RVETPVLPPVLVPRHTE------IPAEFPPLDDYSHSIPENTNFPAGIE----------P 128

Query: 189 NSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDG--SQPMDT-- 244
            S+ P                           +TPPP YL  ED  T D   +  MD   
Sbjct: 129 QSNIP---------------------------ETPPPGYLS-EDGETSDHQMNHSMDAGS 160

Query: 245 -NMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPS 303
            N+   P+    N  D+Q V Y EP  WCSI YYELN RVGE FHAS  S+ VDGFTDPS
Sbjct: 161 PNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPS 220

Query: 304 NNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYH 363
           N++ RFCLGLLSNVNRN+ +E TRRHIG+GV LYY+GGEV+AECLSDS+IFVQS NCN  
Sbjct: 221 NSE-RFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQR 279

Query: 364 HGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAE 423
           +G+HP TVCKIP GC+LKIFNNQEFA LLAQSVN GFE VY+LT+MCTIRMSFVKGWGAE
Sbjct: 280 YGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAE 339

Query: 424 YHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS 465
           Y RQ VTSTPCWIE+HL+GPLQWLDKVLTQMGSP    SSVS
Sbjct: 340 YRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS 381


>gi|223029440 mothers against decapentaplegic homolog 3 isoform 2
           [Homo sapiens]
          Length = 320

 Score =  409 bits (1052), Expect = e-114
 Identities = 215/365 (58%), Positives = 247/365 (67%), Gaps = 50/365 (13%)

Query: 106 LECCEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPH 165
           +E CEF F  K+ EVC+NPYHY+RVE+PVLPPVLVPRH+E      + A+F  L      
Sbjct: 1   MELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTE------IPAEFPPLDDYSHS 54

Query: 166 MPLNATFPDSFQQPNSHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPP 225
           +P N  FP   +          P S+ P                           +TPPP
Sbjct: 55  IPENTNFPAGIE----------PQSNIP---------------------------ETPPP 77

Query: 226 AYLPPEDPMTQDG--SQPMDT---NMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELN 280
            YL  ED  T D   +  MD    N+   P+    N  D+Q V Y EP  WCSI YYELN
Sbjct: 78  GYLS-EDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELN 136

Query: 281 NRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVG 340
            RVGE FHAS  S+ VDGFTDPSN++ RFCLGLLSNVNRN+ +E TRRHIG+GV LYY+G
Sbjct: 137 QRVGETFHASQPSMTVDGFTDPSNSE-RFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIG 195

Query: 341 GEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGF 400
           GEV+AECLSDS+IFVQS NCN  +G+HP TVCKIP GC+LKIFNNQEFA LLAQSVN GF
Sbjct: 196 GEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGF 255

Query: 401 ETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNP 460
           E VY+LT+MCTIRMSFVKGWGAEY RQ VTSTPCWIE+HL+GPLQWLDKVLTQMGSP   
Sbjct: 256 EAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIR 315

Query: 461 ISSVS 465
            SSVS
Sbjct: 316 CSSVS 320


>gi|223029444 mothers against decapentaplegic homolog 3 isoform 4
           [Homo sapiens]
          Length = 230

 Score =  343 bits (881), Expect = 1e-94
 Identities = 164/221 (74%), Positives = 183/221 (82%), Gaps = 1/221 (0%)

Query: 245 NMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSN 304
           N+   P+    N  D+Q V Y EP  WCSI YYELN RVGE FHAS  S+ VDGFTDPSN
Sbjct: 11  NLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSN 70

Query: 305 NKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHH 364
           ++ RFCLGLLSNVNRN+ +E TRRHIG+GV LYY+GGEV+AECLSDS+IFVQS NCN  +
Sbjct: 71  SE-RFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRY 129

Query: 365 GFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEY 424
           G+HP TVCKIP GC+LKIFNNQEFA LLAQSVN GFE VY+LT+MCTIRMSFVKGWGAEY
Sbjct: 130 GWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEY 189

Query: 425 HRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS 465
            RQ VTSTPCWIE+HL+GPLQWLDKVLTQMGSP    SSVS
Sbjct: 190 RRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS 230


>gi|4885457 mothers against decapentaplegic homolog 4 [Homo sapiens]
          Length = 552

 Score =  265 bits (677), Expect = 7e-71
 Identities = 190/530 (35%), Positives = 265/530 (50%), Gaps = 95/530 (17%)

Query: 14  VKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPG-QPSNCVTIPRSLD 72
           V  L+  +QG E E +A++A+++LVKKLK+KK  ++ L  A++  G  PS CVTI R+LD
Sbjct: 20  VHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLD 79

Query: 73  GRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYKRVES 132
           GRLQV+ RKG PHVIY R+WRWPDL   +ELK ++ C++ F  K   VC+NPYHY+RV S
Sbjct: 80  GRLQVAGRKGFPHVIYARLWRWPDLHK-NELKHVKYCQYAFDLKCDSVCVNPYHYERVVS 138

Query: 133 PVL-----------PPVLVPRHS---EYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQ 178
           P +           P  ++ +     ++  Q SL  +  ++ Q   H P N    +++  
Sbjct: 139 PGIDLSGLTLQSNAPSSMMVKDEYVHDFEGQPSLSTEGHSI-QTIQHPPSNRASTETYST 197

Query: 179 P-----------NSHPFPHSP--NSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPP 225
           P           ++  FP+ P  ++S P S    S +      +S P    Q    T  P
Sbjct: 198 PALLAPSESNATSTANFPNIPVASTSQPASILGGSHSEGLLQIASGPQPGQQQNGFTGQP 257

Query: 226 AYLPPEDPMTQDGSQ--PMDTNM---------MAPPLPSEINRGDVQAVAYE-------- 266
           A        T  GS+  P   N+           PP+P   + G    V  E        
Sbjct: 258 ATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPP--HPGHYWPVHNELAFQPPIS 315

Query: 267 ---EPKHWCSIVYYELNNRVGEAFHASSTS--VLVDGFTDPSNNKNRFCLGLLSNVNRNS 321
               P++WCSI Y+E++ +VGE F   S+   V VDG+ DPS   +RFCLG LSNV+R  
Sbjct: 316 NHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGG-DRFCLGQLSNVHRTE 374

Query: 322 TIENTRRHIGKGVHLYYVG-GEVYAECLSDSSIFVQSRNCNYHHGFHP-TTVCKIPSGCS 379
            IE  R HIGKGV L   G G+V+  CLSD ++FVQS   +   G  P   V KI     
Sbjct: 375 AIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAY 434

Query: 380 LKIFNNQE-----------------------------------FAQLLAQSVNHGFETVY 404
           +K+F+ ++                                    A  ++ S   G   V 
Sbjct: 435 IKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGI-GVD 493

Query: 405 ELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQM 454
           +L ++C +RMSFVKGWG +Y RQ +  TPCWIEIHLH  LQ LD+VL  M
Sbjct: 494 DLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLLDEVLHTM 543


>gi|218749837 SMAD family member 6 isoform 2 [Homo sapiens]
          Length = 235

 Score = 95.5 bits (236), Expect = 9e-20
 Identities = 75/239 (31%), Positives = 108/239 (45%), Gaps = 17/239 (7%)

Query: 213 GSPFQMPADTPPP-AYLPPED---PMTQDGSQPMDTNMMAP----PLPSEINRGDVQAVA 264
           G P +     PPP + L P D   P+    S    T   A       P E +   +   A
Sbjct: 5   GKPIETQKSPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDA 64

Query: 265 YEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIE 324
             +P HWCS+ Y+E   RVG  +     +V +  F D       FCLG L+   R+ ++ 
Sbjct: 65  -TKPSHWCSVAYWEHRTRVGRLYAVYDQAVSI--FYDLPQGSG-FCLGQLNLEQRSESVR 120

Query: 325 NTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFN 384
            TR  IG G+ L      V+A    +  IFV S   +   G     V K+P G S+K+F+
Sbjct: 121 RTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGG-RALVVRKVPPGYSIKVFD 179

Query: 385 NQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGP 443
            +      A   +   +  Y+     ++R+SF KGWG  Y RQ +TS PCW+EI L+ P
Sbjct: 180 FERSGLQHAPEPDAA-DGPYDPN---SVRISFAKGWGPCYSRQFITSCPCWLEILLNNP 234


>gi|92859871 SMAD family member 6 isoform 1 [Homo sapiens]
          Length = 496

 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 74/232 (31%), Positives = 107/232 (46%), Gaps = 18/232 (7%)

Query: 221 DTPPPAY--LPPED---PMTQDGSQPMDTNMMAP----PLPSEINRGDVQAVAYEEPKHW 271
           ++PPP Y  L P D   P+    S    T   A       P E +   +   A  +P HW
Sbjct: 273 ESPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDA-TKPSHW 331

Query: 272 CSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIG 331
           CS+ Y+E   RVG  +     +V +  F D       FCLG L+   R+ ++  TR  IG
Sbjct: 332 CSVAYWEHRTRVGRLYAVYDQAVSI--FYDLPQGSG-FCLGQLNLEQRSESVRRTRSKIG 388

Query: 332 KGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQL 391
            G+ L      V+A    +  IFV S   +   G     V K+P G S+K+F+ +     
Sbjct: 389 FGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGG-RALVVRKVPPGYSIKVFDFERSGLQ 447

Query: 392 LAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGP 443
            A   +   +  Y+     ++R+SF KGWG  Y RQ +TS PCW+EI L+ P
Sbjct: 448 HAPEPDAA-DGPYDPN---SVRISFAKGWGPCYSRQFITSCPCWLEILLNNP 495



 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 42/116 (36%), Positives = 67/116 (57%), Gaps = 10/116 (8%)

Query: 36  ALVKKLKKKKGAMEELEKAL-SCPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRW 94
           +L+K+LK++  +++ L +A+ S  G P  CV +PR+    L++  +   P ++  R++RW
Sbjct: 178 SLLKRLKER--SLDTLLEAVESRGGVPGGCVLVPRA---DLRLGGQPAPPQLLLGRLFRW 232

Query: 95  PDLQSHHELKPL-ECCEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQ 149
           PDLQ   ELKPL  C  F   +    VC NPYH+ R+  P  PP   P +S  +P+
Sbjct: 233 PDLQHAVELKPLCGCHSFAAAADGPTVCCNPYHFSRLCGPESPP---PPYSRLSPR 285


>gi|5174517 SMAD family member 7 [Homo sapiens]
          Length = 426

 Score = 92.4 bits (228), Expect = 8e-19
 Identities = 111/417 (26%), Positives = 171/417 (41%), Gaps = 107/417 (25%)

Query: 36  ALVKKLKKKKGAMEELEKAL-SCPGQPSNCVTIPRSLDGRL-----------QVSHRKGL 83
           +++KKLK+++  +E L +A+ S  G  + C+ +P  LD RL           Q      L
Sbjct: 98  SVLKKLKERQ--LELLLQAVESRGGTRTACLLLPGRLDCRLGPGAPAGAQPAQPPSSYSL 155

Query: 84  PHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKE-VCINPYHYKRVESPVLPPVLVPR 142
           P ++ C+V+RWPDL+   E+K L CC   +G    E VC                     
Sbjct: 156 P-LLLCKVFRWPDLRHSSEVKRL-CCCESYGKINPELVCC-------------------- 193

Query: 143 HSEYNPQH-SLLAQFRNLGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNSPGSSSS 201
               NP H S L +  +                          P  P S YP      ++
Sbjct: 194 ----NPHHLSRLCELES--------------------------PPPPYSRYPMDFLKPTA 223

Query: 202 TYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQPMDTNMMAPPLPSEINRGDVQ 261
             P +  SS         A+T    YL P            D+ ++  P       GD  
Sbjct: 224 DCPDAVPSS---------AETGGTNYLAP--------GGLSDSQLLLEP-------GD-- 257

Query: 262 AVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNS 321
                   HWC + Y+E   RVG  +     S+  D F D     N FCLG L++ N++ 
Sbjct: 258 ------RSHWCVVAYWEEKTRVGRLYCVQEPSL--DIFYDLPQG-NGFCLGQLNSDNKSQ 308

Query: 322 TIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLK 381
            ++  R  IG G+ L      V+    S   IF++S   + +       V K+  G S+K
Sbjct: 309 LVQKVRSKIGCGIQLTREVDGVWVYNRSSYPIFIKSATLD-NPDSRTLLVHKVFPGFSIK 367

Query: 382 IFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEI 438
            F+ ++ A  L +  +H F  + +     T+++SFVKGWG  Y RQ ++S PCW+E+
Sbjct: 368 AFDYEK-AYSLQRPNDHEF--MQQPWTGFTVQISFVKGWGQCYTRQFISSCPCWLEV 421


>gi|4557317 annexin A11 [Homo sapiens]
          Length = 505

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 34/103 (33%), Positives = 41/103 (39%), Gaps = 4/103 (3%)

Query: 154 AQFRNLGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYP---NSPGSSSSTYPHSPTSS 210
           A   NL    P        P  F QP S   P  P   YP    +P S   +YP  P + 
Sbjct: 68  ANMPNLYPGAPGAGYPPVPPGGFGQPPSAQQPVPPYGMYPPPGGNPPSRMPSYPPYPGAP 127

Query: 211 DPGSPFQMPADTPPPAYLPPEDPMTQDGSQPMDTNMMAPPLPS 253
            PG P   P   PP AY P + P+T  G  P+       P+PS
Sbjct: 128 VPGQPMPPPGQQPPGAY-PGQPPVTYPGQPPVPLPGQQQPVPS 169


>gi|22165433 annexin A11 [Homo sapiens]
          Length = 505

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 34/103 (33%), Positives = 41/103 (39%), Gaps = 4/103 (3%)

Query: 154 AQFRNLGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYP---NSPGSSSSTYPHSPTSS 210
           A   NL    P        P  F QP S   P  P   YP    +P S   +YP  P + 
Sbjct: 68  ANMPNLYPGAPGAGYPPVPPGGFGQPPSAQQPVPPYGMYPPPGGNPPSRMPSYPPYPGAP 127

Query: 211 DPGSPFQMPADTPPPAYLPPEDPMTQDGSQPMDTNMMAPPLPS 253
            PG P   P   PP AY P + P+T  G  P+       P+PS
Sbjct: 128 VPGQPMPPPGQQPPGAY-PGQPPVTYPGQPPVPLPGQQQPVPS 169


>gi|22165431 annexin A11 [Homo sapiens]
          Length = 505

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 34/103 (33%), Positives = 41/103 (39%), Gaps = 4/103 (3%)

Query: 154 AQFRNLGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYP---NSPGSSSSTYPHSPTSS 210
           A   NL    P        P  F QP S   P  P   YP    +P S   +YP  P + 
Sbjct: 68  ANMPNLYPGAPGAGYPPVPPGGFGQPPSAQQPVPPYGMYPPPGGNPPSRMPSYPPYPGAP 127

Query: 211 DPGSPFQMPADTPPPAYLPPEDPMTQDGSQPMDTNMMAPPLPS 253
            PG P   P   PP AY P + P+T  G  P+       P+PS
Sbjct: 128 VPGQPMPPPGQQPPGAY-PGQPPVTYPGQPPVPLPGQQQPVPS 169


>gi|167555104 interferon regulatory factor 4 [Homo sapiens]
          Length = 451

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 53/246 (21%), Positives = 94/246 (38%), Gaps = 38/246 (15%)

Query: 177 QQPNSHPFPHSPNSSYPNSPGSSSSTY----------PHSPTSSDPGSPFQMPADTPPPA 226
           Q   SHP+  +  + YP+ P      Y           + P    P  P+Q P    P  
Sbjct: 145 QMSMSHPY--TMTTPYPSLPAQQVHNYMMPPLDRSWRDYVPDQPHPEIPYQCPMTFGPRG 202

Query: 227 YLPPEDPMTQDGSQPMDT-------NMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYEL 279
           +   + P  ++G Q   T          AP +P+E +    +A+A+ + +    + Y E+
Sbjct: 203 H-HWQGPACENGCQVTGTFYACAPPESQAPGVPTEPSIRSAEALAFSDCRLHICLYYREI 261

Query: 280 NNRVGEAFHASSTSVLVD-GFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYY 338
              V E   +S     +  G T  ++N ++       +  +   IE    H+ +GV L+ 
Sbjct: 262 --LVKELTTSSPEGCRISHGHTYDASNLDQVLFPYPEDNGQRKNIEKLLSHLERGVVLWM 319

Query: 339 VGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVC-----KIPSGCSLKIFNNQEFAQLLA 393
               +YA+ L  S I+             P  +C     K+    + K+F+ Q+F   L 
Sbjct: 320 APDGLYAKRLCQSRIYWDG----------PLALCNDRPNKLERDQTCKLFDTQQFLSELQ 369

Query: 394 QSVNHG 399
              +HG
Sbjct: 370 AFAHHG 375


>gi|32307128 nuclear receptor coactivator 6 [Homo sapiens]
          Length = 2063

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 34/128 (26%), Positives = 55/128 (42%), Gaps = 10/128 (7%)

Query: 140  VPRHSEYNPQHSLLAQFRNL--GQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNSPG 197
            VP      P H +L Q + +  G      PL+AT   + QQP  +  P S    +PN   
Sbjct: 1143 VPGGPNNMPSHVVLPQNQLMMTGPKPGPSPLSATQGATPQQPPVNSLPSSHGHHFPNVAA 1202

Query: 198  SSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQD-------GSQPMDTNMMAPP 250
             + ++ P +P  + P   +    +  PP+  P E  ++ +       G  P   N+  PP
Sbjct: 1203 PTQTSRPKTPNRASPRPYYPQTPNNRPPSTEPSEISLSPERLNASIAGLFPPQINIPLPP 1262

Query: 251  LPSEINRG 258
             P+ +NRG
Sbjct: 1263 RPN-LNRG 1269



 Score = 29.6 bits (65), Expect = 6.1
 Identities = 40/147 (27%), Positives = 51/147 (34%), Gaps = 35/147 (23%)

Query: 130 VESPVLPPVLVPRHSEYNPQ-HSLLAQFRNLGQ-NEPHMPLNATFPDSFQQPNSHPFPHS 187
           V++P  PP   P  S+   Q H+   Q  N GQ   P M      P     P   P  H 
Sbjct: 366 VQTPSHPPPPYPFGSQQASQAHTNFPQMSNPGQFTAPQMKSLQGGPSRVPTPLQQP--HL 423

Query: 188 PNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMP---------ADTPP-----------PAY 227
            N S    P SS       P+S   GSP   P            PP           P  
Sbjct: 424 TNKS----PASS-------PSSFQQGSPASSPTVNQTQQQMGPRPPQNNPLPQGFQQPVS 472

Query: 228 LPPEDPMTQDGSQPMDTNMMAPPLPSE 254
            P  +PM Q G+ P +  +M    P++
Sbjct: 473 SPGRNPMVQQGNVPPNFMVMQQQPPNQ 499



 Score = 29.3 bits (64), Expect = 7.9
 Identities = 38/143 (26%), Positives = 48/143 (33%), Gaps = 16/143 (11%)

Query: 129 RVESPVLPPVLVPRHSEYNP---QHSLLAQFRNLGQNE----PHMPLNATFPDSFQQPNS 181
           RV +P+  P L  +    +P   Q    A    + Q +    P  P N   P  FQQP S
Sbjct: 413 RVPTPLQQPHLTNKSPASSPSSFQQGSPASSPTVNQTQQQMGPRPPQNNPLPQGFQQPVS 472

Query: 182 HPFPH---SPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDG 238
            P  +      +  PN            P S  PG    MP   PP       +P    G
Sbjct: 473 SPGRNPMVQQGNVPPNFMVMQQQPPNQGPQSLHPGLG-GMPKRLPPGFSAGQANPNFMQG 531

Query: 239 SQPMDT-----NMMAPPLPSEIN 256
             P  T     N  AP L +  N
Sbjct: 532 QVPSTTATTPGNSGAPQLQANQN 554


>gi|118498345 AT-binding transcription factor 1 [Homo sapiens]
          Length = 3703

 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 34/132 (25%), Positives = 54/132 (40%), Gaps = 4/132 (3%)

Query: 125  YHYKRVESPVLPPVLVPRHSE--YNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPNSH 182
            YH    ES +     + +H E   +   ++    RN  ++   +P +A FPD      S 
Sbjct: 3529 YHCLACESALCGEEALSQHLESALHKHRTITRAARNAKEHPSLLPHSACFPDPSTASTSQ 3588

Query: 183  PFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQPM 242
               HS +S  P S  + SS  PH+   S P    +  A  PP    PP    +   S   
Sbjct: 3589 SAAHSNDSPPPPSAAAPSSASPHASRKSWPQVVSRASAAKPPS--FPPLSSSSTVTSSSC 3646

Query: 243  DTNMMAPPLPSE 254
             T+ + P +P++
Sbjct: 3647 STSGVQPSMPTD 3658



 Score = 34.3 bits (77), Expect = 0.25
 Identities = 32/120 (26%), Positives = 43/120 (35%), Gaps = 39/120 (32%)

Query: 135  LPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMP--------LNATFPDSFQQPNSH-PFP 185
            +PPVL+P                  G N P +P        L +  P+    P++  P P
Sbjct: 3121 IPPVLLP------------------GLNSPSLPGFTPSNTALTSPKPNLMGLPSTTVPSP 3162

Query: 186  HSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPAD------------TPPPAYLPPEDP 233
              P S  PN P S+S + P    ++    P Q P               PPPA  PP  P
Sbjct: 3163 GLPTSGLPNKPSSASLSSPTPAQATMAMGPQQPPQQQQQQQQPQVQQPPPPPAAQPPPTP 3222


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 39/127 (30%), Positives = 51/127 (40%), Gaps = 18/127 (14%)

Query: 132 SPVLPPVLVPRHSEYNPQ--HSLLAQFRNLGQNEPHMPLNATFPDSFQQPNSHPFPHSPN 189
           SP L P+  P     N    H L A F       P  P+ A F      P + P P SP+
Sbjct: 639 SPPLSPLATPSPQAPNALAVHLLQAPF----SPPPSPPVQAPF-----SPPASP-PVSPS 688

Query: 190 SSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPP------EDPMTQDGSQPMD 243
           ++ P+    S +  P     S P SP   P+ TPPP   PP      + P +   S PM 
Sbjct: 689 ATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMS 748

Query: 244 TNMMAPP 250
            +   PP
Sbjct: 749 PSATPPP 755



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 36/138 (26%), Positives = 52/138 (37%), Gaps = 29/138 (21%)

Query: 130 VESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPNSHP---FPH 186
           +++P  PP   P  + ++P  S            P +  +AT P       + P    P 
Sbjct: 661 LQAPFSPPPSPPVQAPFSPPAS------------PPVSPSATPPSQAPPSLAAPPLQVPP 708

Query: 187 SPNSSYPNSPGSSSSTYPHSPTS--------SDPGSPFQMPADTPPP------AYLPPED 232
           SP +S P SP ++       P +        S P SP   P+ TPPP      A  P + 
Sbjct: 709 SPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQV 768

Query: 233 PMTQDGSQPMDTNMMAPP 250
           P +   S PM      PP
Sbjct: 769 PPSPPASLPMSPLAKPPP 786



 Score = 33.1 bits (74), Expect = 0.55
 Identities = 32/132 (24%), Positives = 43/132 (32%), Gaps = 27/132 (20%)

Query: 133 PVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSY 192
           P +PP+L     +  P          L +  P  P     P              P  + 
Sbjct: 755 PRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATP--------------PLQAL 800

Query: 193 PNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYL---------PPEDPMTQDGSQP-- 241
           P+ P S     P SP++S P SP   P    PP            PP  P  Q   +P  
Sbjct: 801 PSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPT 860

Query: 242 --MDTNMMAPPL 251
              DT++  P L
Sbjct: 861 PGPDTSVSGPRL 872


>gi|209862789 microtubule associated monoxygenase, calponin and LIM
            domain containing 3 isoform 1 [Homo sapiens]
          Length = 2002

 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 45/163 (27%), Positives = 59/163 (36%), Gaps = 29/163 (17%)

Query: 95   PDLQSHHELKPLECCEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLA 154
            P    H E  P +        ++  +   P H    E P LPPV      E +P+  L  
Sbjct: 1141 PASPKHQERGPSQATSPIRSPQESALLFIPVHSPSTEGPQLPPVPAAT-QEKSPEERLFP 1199

Query: 155  QFRNLGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGS 214
                    EP +P      D+   P+     HSP  S P        T P + T   PGS
Sbjct: 1200 --------EPLLPKEKPKADA---PSDLKAVHSPIRSQP-------VTLPEARTPVSPGS 1241

Query: 215  PFQMP---ADTPPPAYLPPEDPMTQDGSQPMDTNMMAPPLPSE 254
            P   P   A TPPP+ LP         SQP  +     P P++
Sbjct: 1242 PQPQPPVAASTPPPSPLP-------ICSQPQPSTEATVPSPTQ 1277



 Score = 29.3 bits (64), Expect = 7.9
 Identities = 36/143 (25%), Positives = 54/143 (37%), Gaps = 26/143 (18%)

Query: 132  SPVLPPVLVPRHS-EYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPNSHPFPHSPNS 190
            +P   PV +  +S E +PQ   L   + L      +P     P    +P S P P SP+ 
Sbjct: 1355 TPAFRPVSLKSYSVEKSPQDEGLHLLKPLS-----IPKRLGLPKPEGEPLSLPTPRSPSD 1409

Query: 191  SYPNSP-------GSSSSTYPHSPTSS----------DPGSPFQMPADTPPPAYLPPEDP 233
                S         SSS    H  +S+             S    P  +PPP   P E+P
Sbjct: 1410 RELRSAQEERRELSSSSGLGLHGSSSNMKTLGSQSFNTSDSAMLTPPSSPPPPPPPGEEP 1469

Query: 234  MT---QDGSQPMDTNMMAPPLPS 253
             T   +      + +++ PPLP+
Sbjct: 1470 ATLRRKLREAEPNASVVPPPLPA 1492


>gi|42544123 splicing factor 1 isoform 3 [Homo sapiens]
          Length = 548

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 28/88 (31%), Positives = 39/88 (44%), Gaps = 12/88 (13%)

Query: 181 SHPFPHSPNSSYPNSPGSSSSTYPH---SPTSSDPGSPFQMPADTPPPAYL-PPEDPMTQ 236
           S P+ H  +   P  PG    ++PH   S T    G P Q   + PPP ++ PP  PM Q
Sbjct: 376 SRPY-HGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQ 434

Query: 237 D-------GSQPMDTNMMAPPLPSEINR 257
                   G  PMD  + + P+ S + R
Sbjct: 435 GPHPPGHHGPPPMDQYLGSTPVGSGVYR 462


>gi|42544125 splicing factor 1 isoform 2 [Homo sapiens]
          Length = 638

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 28/88 (31%), Positives = 39/88 (44%), Gaps = 12/88 (13%)

Query: 181 SHPFPHSPNSSYPNSPGSSSSTYPH---SPTSSDPGSPFQMPADTPPPAYL-PPEDPMTQ 236
           S P+ H  +   P  PG    ++PH   S T    G P Q   + PPP ++ PP  PM Q
Sbjct: 376 SRPY-HGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQ 434

Query: 237 D-------GSQPMDTNMMAPPLPSEINR 257
                   G  PMD  + + P+ S + R
Sbjct: 435 GPHPPGHHGPPPMDQYLGSTPVGSGVYR 462



 Score = 32.3 bits (72), Expect = 0.94
 Identities = 31/127 (24%), Positives = 43/127 (33%), Gaps = 19/127 (14%)

Query: 136 PPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNS 195
           PP   P      P    L  ++   Q  P  P     P S    +S P P   N++   +
Sbjct: 480 PPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPP-----PPSSSMASSTPLPWQQNTTTTTT 534

Query: 196 PGSSSSTYP----HSPTSSDPGSP--------FQMPADTPPPAYLPPEDPMTQDGSQPMD 243
              + S  P     +  ++ PG+P          +P    PP  LPP  P       P  
Sbjct: 535 SAGTGSIPPWQQQQAAAAASPGAPQMQGNPTMVPLPPGVQPP--LPPGAPPPPPPPPPGS 592

Query: 244 TNMMAPP 250
             MM PP
Sbjct: 593 AGMMIPP 599


>gi|42544130 splicing factor 1 isoform 1 [Homo sapiens]
          Length = 639

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 28/88 (31%), Positives = 39/88 (44%), Gaps = 12/88 (13%)

Query: 181 SHPFPHSPNSSYPNSPGSSSSTYPH---SPTSSDPGSPFQMPADTPPPAYL-PPEDPMTQ 236
           S P+ H  +   P  PG    ++PH   S T    G P Q   + PPP ++ PP  PM Q
Sbjct: 376 SRPY-HGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQ 434

Query: 237 D-------GSQPMDTNMMAPPLPSEINR 257
                   G  PMD  + + P+ S + R
Sbjct: 435 GPHPPGHHGPPPMDQYLGSTPVGSGVYR 462



 Score = 30.4 bits (67), Expect = 3.6
 Identities = 27/85 (31%), Positives = 29/85 (34%), Gaps = 15/85 (17%)

Query: 178 QPNSHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDP---- 233
           Q N    P  P    P  PG+     P  P    PGS   M A  PPP   PP DP    
Sbjct: 561 QGNPTMVPLPPGVQPPLPPGA-----PPPPPPPPPGSAGMMYAPPPPPP--PPMDPSNFV 613

Query: 234 ----MTQDGSQPMDTNMMAPPLPSE 254
               M   G  P       PP P +
Sbjct: 614 TMMGMGVAGMPPFGMPPAPPPPPPQ 638


>gi|32699048 family with sequence similarity 70, member B [Homo
           sapiens]
          Length = 326

 Score = 40.8 bits (94), Expect = 0.003
 Identities = 32/100 (32%), Positives = 41/100 (41%), Gaps = 19/100 (19%)

Query: 140 VPRHSEYNPQHSLLAQ--FRNLGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNSP- 196
           VP  + YNP   +LA   FR               P+     +S+P P  P S +P +P 
Sbjct: 235 VPPQTLYNPAQQILAYAGFR-------------LTPEPVPTCSSYPLPLQPCSRFPVAPS 281

Query: 197 ---GSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDP 233
               SS    P SP+SS  G P Q P    P  + P E P
Sbjct: 282 SALASSEDLQPPSPSSSGSGLPGQAPPCYAPTYFPPGEKP 321


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.133    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,028,917
Number of Sequences: 37866
Number of extensions: 1205611
Number of successful extensions: 9740
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 142
Number of HSP's successfully gapped in prelim test: 508
Number of HSP's that attempted gapping in prelim test: 7210
Number of HSP's gapped (non-prelim): 2363
length of query: 465
length of database: 18,247,518
effective HSP length: 106
effective length of query: 359
effective length of database: 14,233,722
effective search space: 5109906198
effective search space used: 5109906198
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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