Guide to the Human Genome
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Search of human proteins with 4885609

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
         (536 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap...  1096   0.0  
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi...  1096   0.0  
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]              819   0.0  
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]      763   0.0  
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]       745   0.0  
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa...   716   0.0  
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa...   716   0.0  
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi...   716   0.0  
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]      669   0.0  
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]     587   e-168
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs...   566   e-161
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs...   566   e-161
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ...   560   e-160
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is...   560   e-160
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]                 553   e-157
gi|4503787 fyn-related kinase [Homo sapiens]                          468   e-132
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]              374   e-104
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...   364   e-100
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...   363   e-100
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]             359   3e-99
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]               359   3e-99
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]             359   3e-99
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]             359   3e-99
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]             359   3e-99
gi|18250298 src-related kinase lacking C-terminal regulatory tyr...   354   1e-97
gi|148596974 TXK tyrosine kinase [Homo sapiens]                       328   6e-90
gi|130977759 tec protein tyrosine kinase [Homo sapiens]               322   4e-88
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]   318   6e-87
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]                305   5e-83
gi|187475373 c-src tyrosine kinase [Homo sapiens]                     294   1e-79

>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score = 1096 bits (2834), Expect = 0.0
 Identities = 536/536 (100%), Positives = 536/536 (100%)

Query: 1   MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE 60
           MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE
Sbjct: 1   MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE 60

Query: 61  PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD 120
           PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
Sbjct: 61  PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD 120

Query: 121 WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES 180
           WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
Sbjct: 121 WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES 180

Query: 181 ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL 240
           ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
Sbjct: 181 ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL 240

Query: 241 CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL 300
           CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
Sbjct: 241 CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL 300

Query: 301 KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY 360
           KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY
Sbjct: 301 KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY 360

Query: 361 LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT 420
           LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
Sbjct: 361 LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT 420

Query: 421 ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 480
           ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
Sbjct: 421 ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 480

Query: 481 GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
           GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
Sbjct: 481 GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536


>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score = 1096 bits (2834), Expect = 0.0
 Identities = 536/536 (100%), Positives = 536/536 (100%)

Query: 1   MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE 60
           MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE
Sbjct: 1   MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE 60

Query: 61  PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD 120
           PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
Sbjct: 61  PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD 120

Query: 121 WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES 180
           WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
Sbjct: 121 WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES 180

Query: 181 ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL 240
           ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
Sbjct: 181 ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL 240

Query: 241 CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL 300
           CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
Sbjct: 241 CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL 300

Query: 301 KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY 360
           KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY
Sbjct: 301 KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY 360

Query: 361 LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT 420
           LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
Sbjct: 361 LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT 420

Query: 421 ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 480
           ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
Sbjct: 421 ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 480

Query: 481 GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
           GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
Sbjct: 481 GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536


>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
          Length = 543

 Score =  819 bits (2116), Expect = 0.0
 Identities = 401/543 (73%), Positives = 450/543 (82%), Gaps = 7/543 (1%)

Query: 1   MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE 60
           MG  KSK   +   +   E            + A  T   P  +   +G +  F+  +  
Sbjct: 1   MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMT 60

Query: 61  P-------KLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQI 113
           P         FGG +SS +V        L GGVT FVALYDYE+RT  DLSFKKGER QI
Sbjct: 61  PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI 120

Query: 114 VNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRG 173
           +NNTEGDWW A S++TG+ GYIPSNYVAP+DSIQAEEWYFGK+ R+++ERLLLN  N RG
Sbjct: 121 INNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRG 180

Query: 174 TFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYY 233
            FLVRESETTKGAY LS+ D+D  +G NVKHYKIRKLD+GG+YIT+R QF++LQ+LV +Y
Sbjct: 181 IFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY 240

Query: 234 SKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT 293
           ++HADGLCH+LTTVCPT KPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT
Sbjct: 241 TEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT 300

Query: 294 RVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFL 353
           +VAIKTLKPGTM PEAFLQEAQ+MKKLRH+KLV LYAVVSEEPIYIVTE+MSKGSLLDFL
Sbjct: 301 KVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFL 360

Query: 354 KGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARL 413
           K   GKYL+LPQLVDMAAQIA GMAY+ERMNY+HRDLRAANILVGENLVCK+ADFGLARL
Sbjct: 361 KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARL 420

Query: 414 IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNRE 473
           IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL TEL TKGRVPYPGMVNRE
Sbjct: 421 IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNRE 480

Query: 474 VLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPG 533
           VL+QVERGYRMPCP  CPESLH+LM  CW+K+P+ERPTFEY+Q+FLEDYFT+TEPQYQPG
Sbjct: 481 VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPG 540

Query: 534 ENL 536
           ENL
Sbjct: 541 ENL 543


>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
          Length = 534

 Score =  763 bits (1970), Expect = 0.0
 Identities = 366/475 (77%), Positives = 417/475 (87%), Gaps = 4/475 (0%)

Query: 63  LFGGFNSSD-TVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDW 121
           +FGG NSS  T T   R G    GVT FVALYDYE+RTE DLSF KGE+ QI+N++EGDW
Sbjct: 63  VFGGVNSSSHTGTLRTRGGT---GVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDW 119

Query: 122 WLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESE 181
           W A SL+TG+TGYIPSNYVAP DSIQAEEWYFGK+ R+++ER LL+  NPRGTFL+RESE
Sbjct: 120 WEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESE 179

Query: 182 TTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLC 241
           TTKGAY LS+ D+D+ KG +VKHYKIRKLD+GG+YIT+R QF +LQQLV +YS+ ADGLC
Sbjct: 180 TTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLC 239

Query: 242 HRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLK 301
             LT +  +  PQT GLAKDAWE+ R SL LE KLGQGCF EVW+GTWNG T+VAIKTLK
Sbjct: 240 FNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLK 299

Query: 302 PGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYL 361
           PGTMSPE+FL+EAQ+MKKL+H+KLVQLYAVVSEEPIYIVTEYM+KGSLLDFLK   G+ L
Sbjct: 300 PGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRAL 359

Query: 362 RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTA 421
           +LP LVDMAAQ+A+GMAY+ERMNY+HRDLR+ANILVG  L+CK+ADFGLARLIEDNEYTA
Sbjct: 360 KLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTA 419

Query: 422 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG 481
           RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTEL TKGRVPYPGM NREVL+QVERG
Sbjct: 420 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERG 479

Query: 482 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
           YRMPCP +CP SLH+LM  CW+K+PEERPTFEYLQ+FLEDYFT+TEPQYQPGENL
Sbjct: 480 YRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 534


>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
          Length = 537

 Score =  745 bits (1923), Expect = 0.0
 Identities = 362/478 (75%), Positives = 413/478 (86%), Gaps = 7/478 (1%)

Query: 63  LFGGFNSSD-TVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDW 121
           +FGG NSS  T T   R G    GVT FVALYDYE+RTE DLSF KGE+ QI+N++EGDW
Sbjct: 63  VFGGVNSSSHTGTLRTRGGT---GVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDW 119

Query: 122 WLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESE 181
           W A SL+TG+TGYIPSNYVAP DSIQAEEWYFGK+ R+++ER LL+  NPRGTFL+RESE
Sbjct: 120 WEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESE 179

Query: 182 TTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLC 241
           TTKGAY LS+ D+D+ KG +VKHYKIRKLD+GG+YIT+R QF +LQQLV +YS+ A GLC
Sbjct: 180 TTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLC 239

Query: 242 HRLTTVCPTSKPQTQGLA---KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIK 298
            RL   C    P+   L+   KD WEIPRESL+L  +LG G FGEVWMGTWNG T+VAIK
Sbjct: 240 CRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIK 299

Query: 299 TLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETG 358
           TLKPGTMSPE+FL+EAQ+MKKL+H+KLVQLYAVVSEEPIYIVTEYM+KGSLLDFLK   G
Sbjct: 300 TLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEG 359

Query: 359 KYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE 418
           + L+LP LVDMAAQ+A+GMAY+ERMNY+HRDLR+ANILVG  L+CK+ADFGLARLIEDNE
Sbjct: 360 RALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNE 419

Query: 419 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478
           YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTEL TKGRVPYPGM NREVL+QV
Sbjct: 420 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQV 479

Query: 479 ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
           ERGYRMPCP +CP SLH+LM  CW+K+PEERPTFEYLQ+FLEDYFT+TEPQYQPGENL
Sbjct: 480 ERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 537


>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  716 bits (1848), Expect = 0.0
 Identities = 356/530 (67%), Positives = 418/530 (78%), Gaps = 10/530 (1%)

Query: 5   KSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLF 64
           K +P   ++    LE     +GA     P   T ++PAS+  H    + F+  A  P   
Sbjct: 8   KLEPVATAKEDAGLEGDFRSYGAADHYGP-DPTKARPASSFAHIPNYSNFSSQAINP--- 63

Query: 65  GGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLA 124
            GF  S T+      G    GVT F+ALYDYE+RTE DL+F KGE+  I+NNTEGDWW A
Sbjct: 64  -GFLDSGTIR-----GVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEA 117

Query: 125 HSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTK 184
            SLS+G+TG IPSNYVAP DSIQAEEWYFGKI R+++ER LL+  NP+G FL+RESETTK
Sbjct: 118 RSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTK 177

Query: 185 GAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRL 244
           GAY LS+ D+D  +G +VKHYKIRKLD GG+YIT+R QFNS+Q+LV +Y +  DGLC+ L
Sbjct: 178 GAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLL 237

Query: 245 TTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGT 304
              C   KPQT GLAKDAWEI R S+ LE +LG GCFG+VW+GTWNG+T+VA+KTLKPGT
Sbjct: 238 IAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGT 297

Query: 305 MSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLP 364
           MSP+AFL+EAQVMK LRH+KLVQLYAVVSEEPIYIVTE+M  GSLLDFLK   G+ LRLP
Sbjct: 298 MSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLP 357

Query: 365 QLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG 424
           QLVDMAAQ+A GMAY+ERMNY+HRDLRAANILVGE L CK+ADFGLARLI+D+EY   QG
Sbjct: 358 QLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQG 417

Query: 425 AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM 484
           +KFPIKWTAPEAAL+GRFTIKSDVWSFGILLTEL TKGR+PYPGM  REVL+QVE+GY M
Sbjct: 418 SKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHM 477

Query: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGE 534
           PCPP CP SL++ M Q WR +PEERPTFEYLQ+FLEDYFTS EPQYQPG+
Sbjct: 478 PCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527


>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  716 bits (1848), Expect = 0.0
 Identities = 356/530 (67%), Positives = 418/530 (78%), Gaps = 10/530 (1%)

Query: 5   KSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLF 64
           K +P   ++    LE     +GA     P   T ++PAS+  H    + F+  A  P   
Sbjct: 8   KLEPVATAKEDAGLEGDFRSYGAADHYGP-DPTKARPASSFAHIPNYSNFSSQAINP--- 63

Query: 65  GGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLA 124
            GF  S T+      G    GVT F+ALYDYE+RTE DL+F KGE+  I+NNTEGDWW A
Sbjct: 64  -GFLDSGTIR-----GVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEA 117

Query: 125 HSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTK 184
            SLS+G+TG IPSNYVAP DSIQAEEWYFGKI R+++ER LL+  NP+G FL+RESETTK
Sbjct: 118 RSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTK 177

Query: 185 GAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRL 244
           GAY LS+ D+D  +G +VKHYKIRKLD GG+YIT+R QFNS+Q+LV +Y +  DGLC+ L
Sbjct: 178 GAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLL 237

Query: 245 TTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGT 304
              C   KPQT GLAKDAWEI R S+ LE +LG GCFG+VW+GTWNG+T+VA+KTLKPGT
Sbjct: 238 IAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGT 297

Query: 305 MSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLP 364
           MSP+AFL+EAQVMK LRH+KLVQLYAVVSEEPIYIVTE+M  GSLLDFLK   G+ LRLP
Sbjct: 298 MSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLP 357

Query: 365 QLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG 424
           QLVDMAAQ+A GMAY+ERMNY+HRDLRAANILVGE L CK+ADFGLARLI+D+EY   QG
Sbjct: 358 QLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQG 417

Query: 425 AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM 484
           +KFPIKWTAPEAAL+GRFTIKSDVWSFGILLTEL TKGR+PYPGM  REVL+QVE+GY M
Sbjct: 418 SKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHM 477

Query: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGE 534
           PCPP CP SL++ M Q WR +PEERPTFEYLQ+FLEDYFTS EPQYQPG+
Sbjct: 478 PCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527


>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  716 bits (1848), Expect = 0.0
 Identities = 356/530 (67%), Positives = 418/530 (78%), Gaps = 10/530 (1%)

Query: 5   KSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLF 64
           K +P   ++    LE     +GA     P   T ++PAS+  H    + F+  A  P   
Sbjct: 8   KLEPVATAKEDAGLEGDFRSYGAADHYGP-DPTKARPASSFAHIPNYSNFSSQAINP--- 63

Query: 65  GGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLA 124
            GF  S T+      G    GVT F+ALYDYE+RTE DL+F KGE+  I+NNTEGDWW A
Sbjct: 64  -GFLDSGTIR-----GVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEA 117

Query: 125 HSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTK 184
            SLS+G+TG IPSNYVAP DSIQAEEWYFGKI R+++ER LL+  NP+G FL+RESETTK
Sbjct: 118 RSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTK 177

Query: 185 GAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRL 244
           GAY LS+ D+D  +G +VKHYKIRKLD GG+YIT+R QFNS+Q+LV +Y +  DGLC+ L
Sbjct: 178 GAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLL 237

Query: 245 TTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGT 304
              C   KPQT GLAKDAWEI R S+ LE +LG GCFG+VW+GTWNG+T+VA+KTLKPGT
Sbjct: 238 IAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGT 297

Query: 305 MSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLP 364
           MSP+AFL+EAQVMK LRH+KLVQLYAVVSEEPIYIVTE+M  GSLLDFLK   G+ LRLP
Sbjct: 298 MSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLP 357

Query: 365 QLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG 424
           QLVDMAAQ+A GMAY+ERMNY+HRDLRAANILVGE L CK+ADFGLARLI+D+EY   QG
Sbjct: 358 QLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQG 417

Query: 425 AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM 484
           +KFPIKWTAPEAAL+GRFTIKSDVWSFGILLTEL TKGR+PYPGM  REVL+QVE+GY M
Sbjct: 418 SKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHM 477

Query: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGE 534
           PCPP CP SL++ M Q WR +PEERPTFEYLQ+FLEDYFTS EPQYQPG+
Sbjct: 478 PCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527


>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
          Length = 482

 Score =  669 bits (1725), Expect = 0.0
 Identities = 333/475 (70%), Positives = 379/475 (79%), Gaps = 56/475 (11%)

Query: 63  LFGGFNSSD-TVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDW 121
           +FGG NSS  T T   R G    GVT FVALYDYE+RTE DLSF KGE+ QI+N++EGDW
Sbjct: 63  VFGGVNSSSHTGTLRTRGGT---GVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDW 119

Query: 122 WLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESE 181
           W A SL+TG+TGYIPSNYVAP DSIQAEEWYFGK+ R+++ER LL+  NPRGTFL+RESE
Sbjct: 120 WEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESE 179

Query: 182 TTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLC 241
           TTKGAY LS+ D+D+ KG +VKHYKIRKLD+GG+YIT+R QF +LQQLV +YS       
Sbjct: 180 TTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYS------- 232

Query: 242 HRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLK 301
                                                        GTWNG T+VAIKTLK
Sbjct: 233 ---------------------------------------------GTWNGNTKVAIKTLK 247

Query: 302 PGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYL 361
           PGTMSPE+FL+EAQ+MKKL+H+KLVQLYAVVSEEPIYIVTEYM+KGSLLDFLK   G+ L
Sbjct: 248 PGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRAL 307

Query: 362 RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTA 421
           +LP LVDMAAQ+A+GMAY+ERMNY+HRDLR+ANILVG  L+CK+ADFGLARLIEDNEYTA
Sbjct: 308 KLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTA 367

Query: 422 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG 481
           RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTEL TKGRVPYPGM NREVL+QVERG
Sbjct: 368 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERG 427

Query: 482 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
           YRMPCP +CP SLH+LM  CW+K+PEERPTFEYLQ+FLEDYFT+TEPQYQPGENL
Sbjct: 428 YRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 482


>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
          Length = 526

 Score =  587 bits (1513), Expect = e-168
 Identities = 291/504 (57%), Positives = 378/504 (75%), Gaps = 13/504 (2%)

Query: 28  GGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVT 87
           GG  F  ++T + P        P++   P         G NS ++ T   R       + 
Sbjct: 33  GGNTFSKTETSASPHCPVYVPDPTSTIKP---------GPNSHNSNTPGIREAGSEDIIV 83

Query: 88  TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQ 147
             VALYDYE+    DLSF+KG+++ ++  + G+WW A SL+T + GYIPSNYVA  DS++
Sbjct: 84  --VALYDYEAIHHEDLSFQKGDQMVVLEES-GEWWKARSLATRKEGYIPSNYVARVDSLE 140

Query: 148 AEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKI 207
            EEW+F  I+R+++ER LL   N  G+F++R+SETTKG+Y LSV D+D  +G  VKHYKI
Sbjct: 141 TEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKI 200

Query: 208 RKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPR 267
           R LD+GGFYI+ R+ F++LQ+LV +Y K  DGLC +L+  C +SKPQ +   KDAWEIPR
Sbjct: 201 RTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQ-KPWEKDAWEIPR 259

Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQ 327
           ESL+LE KLG G FGEVWM T+N  T+VA+KT+KPG+MS EAFL EA VMK L+H+KLV+
Sbjct: 260 ESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVK 319

Query: 328 LYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVH 387
           L+AVV++EPIYI+TE+M+KGSLLDFLK + G    LP+L+D +AQIA GMA++E+ NY+H
Sbjct: 320 LHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIH 379

Query: 388 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 447
           RDLRAANILV  +LVCK+ADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA  +G FTIKSD
Sbjct: 380 RDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSD 439

Query: 448 VWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPE 507
           VWSFGILL E+ T GR+PYPGM N EV+  +ERGYRMP P  CPE L+++M +CW+  PE
Sbjct: 440 VWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPE 499

Query: 508 ERPTFEYLQAFLEDYFTSTEPQYQ 531
           ERPTFEY+Q+ L+D++T+TE QYQ
Sbjct: 500 ERPTFEYIQSVLDDFYTATESQYQ 523


>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score =  566 bits (1459), Expect = e-161
 Identities = 272/454 (59%), Positives = 352/454 (77%), Gaps = 4/454 (0%)

Query: 79  AGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSN 138
           A PL   +   +AL+ YE   + DL F+KGE+L+I+  + G+WW A SL+TGQ G+IP N
Sbjct: 58  ASPLQDNLV--IALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFN 114

Query: 139 YVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAK 198
           +VA ++S++ E W+F  ++R+++ER LL   N  G+FL+RESE+T G++ LSV DFD  +
Sbjct: 115 FVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQ 174

Query: 199 GLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGL 258
           G  VKHYKIR LD+GGFYI+ R  F  L +LV +Y+  +DGLC RL+  C T KPQ    
Sbjct: 175 GEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW 234

Query: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMK 318
            +D WE+PRE+L+L  +LG G FGEVWMG +NG T+VA+K+LK G+MSP+AFL EA +MK
Sbjct: 235 -EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMK 293

Query: 319 KLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 378
           +L+H++LV+LYAVV++EPIYI+TEYM  GSL+DFLK  +G  L + +L+DMAAQIA GMA
Sbjct: 294 QLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA 353

Query: 379 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438
           ++E  NY+HRDLRAANILV + L CK+ADFGLARLIEDNEYTAR+GAKFPIKWTAPEA  
Sbjct: 354 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN 413

Query: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLM 498
           YG FTIKSDVWSFGILLTE+ T GR+PYPGM N EV+  +ERGYRM  P  CPE L+ LM
Sbjct: 414 YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLM 473

Query: 499 CQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQP 532
             CW++ PE+RPTF+YL++ LED+FT+TE QYQP
Sbjct: 474 RLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQP 507


>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score =  566 bits (1459), Expect = e-161
 Identities = 272/454 (59%), Positives = 352/454 (77%), Gaps = 4/454 (0%)

Query: 79  AGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSN 138
           A PL   +   +AL+ YE   + DL F+KGE+L+I+  + G+WW A SL+TGQ G+IP N
Sbjct: 58  ASPLQDNLV--IALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFN 114

Query: 139 YVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAK 198
           +VA ++S++ E W+F  ++R+++ER LL   N  G+FL+RESE+T G++ LSV DFD  +
Sbjct: 115 FVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQ 174

Query: 199 GLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGL 258
           G  VKHYKIR LD+GGFYI+ R  F  L +LV +Y+  +DGLC RL+  C T KPQ    
Sbjct: 175 GEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW 234

Query: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMK 318
            +D WE+PRE+L+L  +LG G FGEVWMG +NG T+VA+K+LK G+MSP+AFL EA +MK
Sbjct: 235 -EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMK 293

Query: 319 KLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 378
           +L+H++LV+LYAVV++EPIYI+TEYM  GSL+DFLK  +G  L + +L+DMAAQIA GMA
Sbjct: 294 QLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA 353

Query: 379 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438
           ++E  NY+HRDLRAANILV + L CK+ADFGLARLIEDNEYTAR+GAKFPIKWTAPEA  
Sbjct: 354 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN 413

Query: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLM 498
           YG FTIKSDVWSFGILLTE+ T GR+PYPGM N EV+  +ERGYRM  P  CPE L+ LM
Sbjct: 414 YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLM 473

Query: 499 CQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQP 532
             CW++ PE+RPTF+YL++ LED+FT+TE QYQP
Sbjct: 474 RLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQP 507


>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform B [Homo sapiens]
          Length = 491

 Score =  560 bits (1444), Expect = e-160
 Identities = 267/443 (60%), Positives = 346/443 (78%), Gaps = 3/443 (0%)

Query: 90  VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAE 149
           VALY Y+     DLSFKKGE+++++    G+WW A SL T + G+IPSNYVA  ++++ E
Sbjct: 48  VALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLETE 106

Query: 150 EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRK 209
           EW+F  ITR+++ER LL   N  G FL+RESET KG++ LSV DFD   G  +KHYKIR 
Sbjct: 107 EWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRS 166

Query: 210 LDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRES 269
           LD+GG+YI+ R  F  +  ++ +Y K ADGLC RL   C + KPQ +   KDAWEIPRES
Sbjct: 167 LDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQ-KPWDKDAWEIPRES 225

Query: 270 LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY 329
           ++L  +LG G FGEVWMG +N +T+VA+KTLKPGTMS +AFL+EA +MK L+H+KLV+LY
Sbjct: 226 IKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY 285

Query: 330 AVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388
           AVV+ EEPIYI+TEYM+KGSLLDFLK + G  + LP+L+D +AQIA GMAY+ER NY+HR
Sbjct: 286 AVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHR 345

Query: 389 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 448
           DLRAAN+LV E+L+CK+ADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA  +G FTIKSDV
Sbjct: 346 DLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDV 405

Query: 449 WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEE 508
           WSFGILL E+ T G++PYPG  N +V+  + +GYRMP    CP+ L+D+M  CW+++ EE
Sbjct: 406 WSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEE 465

Query: 509 RPTFEYLQAFLEDYFTSTEPQYQ 531
           RPTF+YLQ+ L+D++T+TE QYQ
Sbjct: 466 RPTFDYLQSVLDDFYTATEGQYQ 488


>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform A [Homo sapiens]
          Length = 512

 Score =  560 bits (1444), Expect = e-160
 Identities = 267/443 (60%), Positives = 346/443 (78%), Gaps = 3/443 (0%)

Query: 90  VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAE 149
           VALY Y+     DLSFKKGE+++++    G+WW A SL T + G+IPSNYVA  ++++ E
Sbjct: 69  VALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLETE 127

Query: 150 EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRK 209
           EW+F  ITR+++ER LL   N  G FL+RESET KG++ LSV DFD   G  +KHYKIR 
Sbjct: 128 EWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRS 187

Query: 210 LDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRES 269
           LD+GG+YI+ R  F  +  ++ +Y K ADGLC RL   C + KPQ +   KDAWEIPRES
Sbjct: 188 LDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQ-KPWDKDAWEIPRES 246

Query: 270 LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY 329
           ++L  +LG G FGEVWMG +N +T+VA+KTLKPGTMS +AFL+EA +MK L+H+KLV+LY
Sbjct: 247 IKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY 306

Query: 330 AVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388
           AVV+ EEPIYI+TEYM+KGSLLDFLK + G  + LP+L+D +AQIA GMAY+ER NY+HR
Sbjct: 307 AVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHR 366

Query: 389 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 448
           DLRAAN+LV E+L+CK+ADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA  +G FTIKSDV
Sbjct: 367 DLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDV 426

Query: 449 WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEE 508
           WSFGILL E+ T G++PYPG  N +V+  + +GYRMP    CP+ L+D+M  CW+++ EE
Sbjct: 427 WSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEE 486

Query: 509 RPTFEYLQAFLEDYFTSTEPQYQ 531
           RPTF+YLQ+ L+D++T+TE QYQ
Sbjct: 487 RPTFDYLQSVLDDFYTATEGQYQ 509


>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
          Length = 505

 Score =  553 bits (1426), Expect = e-157
 Identities = 278/443 (62%), Positives = 338/443 (76%), Gaps = 5/443 (1%)

Query: 90  VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAE 149
           VALYDY +  + DL   KGE+LQ++  T GDWWLA SL TG+ GY+PSN+VA  +S++ E
Sbjct: 64  VALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESLEME 122

Query: 150 EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRK 209
            W+F    R+E+ER LL   N  G+FL+RESET KGA+ LSV D    +G  +KHYKIR 
Sbjct: 123 RWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDV-TTQGELIKHYKIRC 181

Query: 210 LDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRES 269
           LD GG+YI+ R  F SLQ LV +YSK  DGLC RLT  C    PQ    A+D WEIPR+S
Sbjct: 182 LDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPW-AQDEWEIPRQS 240

Query: 270 LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY 329
           LRL  KLG G FGEVWMG +    +VAIKTLK GTMSPEAFL EA VMK L+HE+LV+LY
Sbjct: 241 LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY 300

Query: 330 AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389
           AVV++EPIYIVTEYM++G LLDFLK + G  L LP+L+DM+AQIA GMAY+ERMN +HRD
Sbjct: 301 AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD 360

Query: 390 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 449
           LRAANILV E L CK+ADFGLAR+I D+EYTA++GAKFPIKWTAPEA  +G FTIK+DVW
Sbjct: 361 LRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVW 419

Query: 450 SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLH-DLMCQCWRKEPEE 508
           SFG+LL E+ T GRVPYPGM N EV+  +ERGYRMP P  CP  L+  ++ +CWR  PEE
Sbjct: 420 SFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEE 479

Query: 509 RPTFEYLQAFLEDYFTSTEPQYQ 531
           RPTFE+LQ+ LED++T+TE QY+
Sbjct: 480 RPTFEFLQSVLEDFYTATERQYE 502


>gi|4503787 fyn-related kinase [Homo sapiens]
          Length = 505

 Score =  468 bits (1205), Expect = e-132
 Identities = 240/462 (51%), Positives = 317/462 (68%), Gaps = 21/462 (4%)

Query: 89  FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSL-------STGQTGYIPSNYVA 141
           FVAL+DY++RT  DLSF+ G++LQ+++     WW A  L       S    GYIPSNYVA
Sbjct: 47  FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106

Query: 142 PSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLN 201
              S+QAE W+FG I R ++E+ LL +EN  G+FL+RESE+ KG + LSV D     G  
Sbjct: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD-----GAV 161

Query: 202 VKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVC-PTSKPQTQGLAK 260
           VKHY+I++LD GGF++T R  F++L + V++Y+K +DGLC +L   C     P    L+ 
Sbjct: 162 VKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSY 221

Query: 261 ---DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVM 317
              D WEI R S++L  +LG G FGEVW G WN TT VA+KTLKPG+M P  FL+EAQ+M
Sbjct: 222 KTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIM 281

Query: 318 KKLRHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376
           K LRH KL+QLYAV + E+PIYI+TE M  GSL ++L+ +TG  + L Q VDMAAQ+ASG
Sbjct: 282 KNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASG 341

Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE-DNE--YTARQGAKFPIKWTA 433
           MAY+E  NY+HRDL A N+LVGE+ + KVADFGLAR+ + DNE  Y +R   K P+KWTA
Sbjct: 342 MAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTA 401

Query: 434 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES 493
           PEA    +F+IKSDVWSFGILL E+ T G++PY GM   +V+  + + YR+P P  CP+ 
Sbjct: 402 PEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQ 461

Query: 494 LHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGEN 535
            +++M +CW  EP+ERPTFE L+  LEDYF  T+  Y    N
Sbjct: 462 FYNIMLECWNAEPKERPTFETLRWKLEDYF-ETDSSYSDANN 502


>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
          Length = 451

 Score =  374 bits (961), Expect = e-104
 Identities = 204/445 (45%), Positives = 272/445 (61%), Gaps = 15/445 (3%)

Query: 89  FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQT---GYIPSNYVAPSDS 145
           +V L+D++SRT+ +LSF+ G+   +    E  WW       G     GY+P NY+A  ++
Sbjct: 13  YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERET 72

Query: 146 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHY 205
           +++E W+FG I+R E+ R L    N  G FL+R SE     Y LSV D        V+HY
Sbjct: 73  VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQA-----VRHY 127

Query: 206 KIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAK-DAWE 264
           KI +   G  ++     F SL +LV Y+   A  L H L    P  K + + L   D WE
Sbjct: 128 KIWRRAGGRLHLNEAVSFLSLPELVNYH--RAQSLSHGLRLAAPCRKHEPEPLPHWDDWE 185

Query: 265 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ-EAQVMKKLRHE 323
            PRE   L  KLG G FGEV+ G W    +VAIK +    +  +  LQ E Q MKKLRH+
Sbjct: 186 RPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHK 245

Query: 324 KLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382
            ++ LYAVVS  +P+YI+TE M+KGSLL+ L+    K L + +L+D+A Q+A GM Y+E 
Sbjct: 246 HILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLES 305

Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 442
            NY+HRDL A NILVGEN +CKV DFGLARLI+++ Y +      P KWTAPEA   G +
Sbjct: 306 QNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDH-NIPYKWTAPEALSRGHY 364

Query: 443 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCW 502
           + KSDVWSFGILL E+ ++G+VPYPGM N E   +V+ GYRMPCP ECP S+H LM  CW
Sbjct: 365 STKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCW 424

Query: 503 RKEPEERPTFEYLQAFLEDYFTSTE 527
            ++PE+RP F+ L+  L   FTS E
Sbjct: 425 CRDPEQRPCFKALRERLSS-FTSYE 448


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score =  364 bits (935), Expect = e-100
 Identities = 213/527 (40%), Positives = 305/527 (57%), Gaps = 38/527 (7%)

Query: 13  QRRRSLEPAENVHGAG-------GG----AFPASQTPSKPASADGHRGPSAAFAPAAAEP 61
           QRR SL     + GAG       GG     F   +   +P ++D        F P     
Sbjct: 12  QRRPSLPALHFIKGAGKKESSRHGGPHCNVFVEHEALQRPVASD--------FEPQGLSE 63

Query: 62  KLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDW 121
                +NS + +     AGP       FVALYD+ +  +  LS  KGE+L+++       
Sbjct: 64  A--ARWNSKENLL----AGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGE 117

Query: 122 WLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESE 181
           W       GQ G++PSNY+ P +S++   WY G ++R  +E LL +  N  G+FLVRESE
Sbjct: 118 WCEAQTKNGQ-GWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESE 174

Query: 182 TTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLC 241
           ++ G   +S+      +G  V HY+I     G  Y++S ++FN+L +LV ++S  ADGL 
Sbjct: 175 SSPGQRSISL----RYEG-RVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLI 229

Query: 242 HRLTTVCPT-SKPQTQGLAK--DAWEIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAI 297
             L    P  +KP   G++   D WE+ R  + ++ KLG G +GEV+ G W   +  VA+
Sbjct: 230 TTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAV 289

Query: 298 KTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGE 356
           KTLK  TM  E FL+EA VMK+++H  LVQL  V + EP  YI+TE+M+ G+LLD+L+  
Sbjct: 290 KTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLREC 349

Query: 357 TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED 416
             + +    L+ MA QI+S M Y+E+ N++HRDL A N LVGEN + KVADFGL+RL+  
Sbjct: 350 NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTG 409

Query: 417 NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLD 476
           + YTA  GAKFPIKWTAPE+  Y +F+IKSDVW+FG+LL E+ T G  PYPG+   +V +
Sbjct: 410 DTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYE 469

Query: 477 QVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523
            +E+ YRM  P  CPE +++LM  CW+  P +RP+F  +    E  F
Sbjct: 470 LLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMF 516


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score =  363 bits (933), Expect = e-100
 Identities = 196/450 (43%), Positives = 280/450 (62%), Gaps = 13/450 (2%)

Query: 79  AGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSN 138
           AGP       FVALYD+ +  +  LS  KGE+L+++       W       GQ G++PSN
Sbjct: 56  AGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQ-GWVPSN 114

Query: 139 YVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAK 198
           Y+ P +S++   WY G ++R  +E LL +  N  G+FLVRESE++ G   +S+      +
Sbjct: 115 YITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISL----RYE 168

Query: 199 GLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQG 257
           G  V HY+I     G  Y++S ++FN+L +LV ++S  ADGL   L    P  +KP   G
Sbjct: 169 G-RVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYG 227

Query: 258 LAK--DAWEIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEA 314
           ++   D WE+ R  + ++ KLG G +GEV+ G W   +  VA+KTLK  TM  E FL+EA
Sbjct: 228 VSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEA 287

Query: 315 QVMKKLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 373
            VMK+++H  LVQL  V + EP  YI+TE+M+ G+LLD+L+    + +    L+ MA QI
Sbjct: 288 AVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQI 347

Query: 374 ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 433
           +S M Y+E+ N++HRDL A N LVGEN + KVADFGL+RL+  + YTA  GAKFPIKWTA
Sbjct: 348 SSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTA 407

Query: 434 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES 493
           PE+  Y +F+IKSDVW+FG+LL E+ T G  PYPG+   +V + +E+ YRM  P  CPE 
Sbjct: 408 PESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEK 467

Query: 494 LHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523
           +++LM  CW+  P +RP+F  +    E  F
Sbjct: 468 VYELMRACWQWNPSDRPSFAEIHQAFETMF 497


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score =  359 bits (922), Expect = 3e-99
 Identities = 198/453 (43%), Positives = 280/453 (61%), Gaps = 13/453 (2%)

Query: 89  FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA 148
           FVALYD+ +  +  LS  KGE+L+++   +   W       GQ G++PSNY+ P +S++ 
Sbjct: 97  FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYITPVNSLEK 155

Query: 149 EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIR 208
             WY G ++R  +E LL +  N  G+FLVRESE++ G   +S+      +G  V HY+I 
Sbjct: 156 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISL----RYEG-RVYHYRIN 208

Query: 209 KLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAK--DAWEI 265
               G  Y+T+ ++F++L +LV ++S  ADGL   L    P  +KP   G++   D WE+
Sbjct: 209 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEM 268

Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324
            R  + ++ KLG G +GEV++G W   +  VA+KTLK  TM  E FL+EA VMK+++H  
Sbjct: 269 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN 328

Query: 325 LVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383
           LVQL  V + E P YIVTEYM  G+LLD+L+    + +    L+ MA QI+S M Y+E+ 
Sbjct: 329 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 388

Query: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443
           N++HRDL A N LVGEN V KVADFGL+RL+  + YTA  GAKFPIKWTAPE+  Y  F+
Sbjct: 389 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 448

Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 503
           IKSDVW+FG+LL E+ T G  PYPG+   +V D +E+GYRM  P  CP  +++LM  CW+
Sbjct: 449 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 508

Query: 504 KEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
             P +RP+F       E  F  +    +  E L
Sbjct: 509 WSPADRPSFAETHQAFETMFHDSSISEEVAEEL 541


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score =  359 bits (922), Expect = 3e-99
 Identities = 198/453 (43%), Positives = 280/453 (61%), Gaps = 13/453 (2%)

Query: 89  FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA 148
           FVALYD+ +  +  LS  KGE+L+++   +   W       GQ G++PSNY+ P +S++ 
Sbjct: 112 FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYITPVNSLEK 170

Query: 149 EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIR 208
             WY G ++R  +E LL +  N  G+FLVRESE++ G   +S+      +G  V HY+I 
Sbjct: 171 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISL----RYEG-RVYHYRIN 223

Query: 209 KLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAK--DAWEI 265
               G  Y+T+ ++F++L +LV ++S  ADGL   L    P  +KP   G++   D WE+
Sbjct: 224 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEM 283

Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324
            R  + ++ KLG G +GEV++G W   +  VA+KTLK  TM  E FL+EA VMK+++H  
Sbjct: 284 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN 343

Query: 325 LVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383
           LVQL  V + E P YIVTEYM  G+LLD+L+    + +    L+ MA QI+S M Y+E+ 
Sbjct: 344 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 403

Query: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443
           N++HRDL A N LVGEN V KVADFGL+RL+  + YTA  GAKFPIKWTAPE+  Y  F+
Sbjct: 404 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 463

Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 503
           IKSDVW+FG+LL E+ T G  PYPG+   +V D +E+GYRM  P  CP  +++LM  CW+
Sbjct: 464 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 523

Query: 504 KEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
             P +RP+F       E  F  +    +  E L
Sbjct: 524 WSPADRPSFAETHQAFETMFHDSSISEEVAEEL 556


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score =  359 bits (922), Expect = 3e-99
 Identities = 215/523 (41%), Positives = 307/523 (58%), Gaps = 34/523 (6%)

Query: 2   GSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEP 61
           GS+ ++P   S RRR  +PA      G   F   +   +P   D          P A   
Sbjct: 24  GSSAARP---SGRRR--DPAGRTTETGFNIFTQHEALHRPYGCD--------VEPQALNE 70

Query: 62  KLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDW 121
            +   ++S + +     + P       FVALYD+ +  +  LS  KGE+L+++   +   
Sbjct: 71  AI--RWSSKENLLGATESDP-----NLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGE 123

Query: 122 WLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESE 181
           W       GQ G++PSNY+ P +S++   WY G ++R  +E LL +  N  G+FLVRESE
Sbjct: 124 WSEVRSKNGQ-GWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESE 180

Query: 182 TTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLC 241
           ++ G   +S+      +G  V HY+I     G  Y+T+ ++F++L +LV ++S  ADGL 
Sbjct: 181 SSPGQLSISL----RYEG-RVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLV 235

Query: 242 HRLTTVCPT-SKPQTQGLAK--DAWEIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAI 297
             L    P  +KP   G++   D WE+ R  + ++ KLG G +GEV++G W   +  VA+
Sbjct: 236 TTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAV 295

Query: 298 KTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGE 356
           KTLK  TM  E FL+EA VMK+++H  LVQL  V + E P YIVTEYM  G+LLD+L+  
Sbjct: 296 KTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLREC 355

Query: 357 TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED 416
             + +    L+ MA QI+S M Y+E+ N++HRDL A N LVGEN V KVADFGL+RL+  
Sbjct: 356 NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTG 415

Query: 417 NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLD 476
           + YTA  GAKFPIKWTAPE+  Y  F+IKSDVW+FG+LL E+ T G  PYPG+   +V D
Sbjct: 416 DTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYD 475

Query: 477 QVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTF-EYLQAF 518
            +E+GYRM  P  CP  +++LM  CW+  P +RP+F E  QAF
Sbjct: 476 LLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAF 518


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score =  359 bits (922), Expect = 3e-99
 Identities = 198/453 (43%), Positives = 280/453 (61%), Gaps = 13/453 (2%)

Query: 89  FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA 148
           FVALYD+ +  +  LS  KGE+L+++   +   W       GQ G++PSNY+ P +S++ 
Sbjct: 97  FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYITPVNSLEK 155

Query: 149 EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIR 208
             WY G ++R  +E LL +  N  G+FLVRESE++ G   +S+      +G  V HY+I 
Sbjct: 156 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISL----RYEG-RVYHYRIN 208

Query: 209 KLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAK--DAWEI 265
               G  Y+T+ ++F++L +LV ++S  ADGL   L    P  +KP   G++   D WE+
Sbjct: 209 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEM 268

Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324
            R  + ++ KLG G +GEV++G W   +  VA+KTLK  TM  E FL+EA VMK+++H  
Sbjct: 269 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN 328

Query: 325 LVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383
           LVQL  V + E P YIVTEYM  G+LLD+L+    + +    L+ MA QI+S M Y+E+ 
Sbjct: 329 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 388

Query: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443
           N++HRDL A N LVGEN V KVADFGL+RL+  + YTA  GAKFPIKWTAPE+  Y  F+
Sbjct: 389 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 448

Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 503
           IKSDVW+FG+LL E+ T G  PYPG+   +V D +E+GYRM  P  CP  +++LM  CW+
Sbjct: 449 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 508

Query: 504 KEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
             P +RP+F       E  F  +    +  E L
Sbjct: 509 WSPADRPSFAETHQAFETMFHDSSISEEVAEEL 541


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score =  359 bits (922), Expect = 3e-99
 Identities = 198/453 (43%), Positives = 280/453 (61%), Gaps = 13/453 (2%)

Query: 89  FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA 148
           FVALYD+ +  +  LS  KGE+L+++   +   W       GQ G++PSNY+ P +S++ 
Sbjct: 76  FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYITPVNSLEK 134

Query: 149 EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIR 208
             WY G ++R  +E LL +  N  G+FLVRESE++ G   +S+      +G  V HY+I 
Sbjct: 135 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISL----RYEG-RVYHYRIN 187

Query: 209 KLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAK--DAWEI 265
               G  Y+T+ ++F++L +LV ++S  ADGL   L    P  +KP   G++   D WE+
Sbjct: 188 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEM 247

Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324
            R  + ++ KLG G +GEV++G W   +  VA+KTLK  TM  E FL+EA VMK+++H  
Sbjct: 248 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN 307

Query: 325 LVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383
           LVQL  V + E P YIVTEYM  G+LLD+L+    + +    L+ MA QI+S M Y+E+ 
Sbjct: 308 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 367

Query: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443
           N++HRDL A N LVGEN V KVADFGL+RL+  + YTA  GAKFPIKWTAPE+  Y  F+
Sbjct: 368 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 427

Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 503
           IKSDVW+FG+LL E+ T G  PYPG+   +V D +E+GYRM  P  CP  +++LM  CW+
Sbjct: 428 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 487

Query: 504 KEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
             P +RP+F       E  F  +    +  E L
Sbjct: 488 WSPADRPSFAETHQAFETMFHDSSISEEVAEEL 520


>gi|18250298 src-related kinase lacking C-terminal regulatory
           tyrosine and N-terminal myristylation sites [Homo
           sapiens]
          Length = 488

 Score =  354 bits (908), Expect = 1e-97
 Identities = 202/469 (43%), Positives = 275/469 (58%), Gaps = 20/469 (4%)

Query: 56  PAAAEPKLFGGFNSSDTVTSPQR---AGPLAGGVTTFVALYDYESRTETDLSFKKGERLQ 112
           PA  EP   G   S D  T P     A P +     F+ALYD+ +R   +LS ++G+RL 
Sbjct: 21  PAGGEPD-HGTPGSLDPNTDPVPTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLC 79

Query: 113 IVNNTEGDWWLAHSLSTGQ--TGYIPSNYVAPS--DSIQAEEWYFGKITRRESERLLLNA 168
            +   EG  ++     +GQ   G +P  +VA +  +++  + WYF  ++R ++++LLL+ 
Sbjct: 80  ALE--EGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSP 137

Query: 169 ENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQ 228
            N  G FL+R SE++ G Y LSV     AK   V HY++     G  Y+     F  L++
Sbjct: 138 PNEPGAFLIRPSESSLGGYSLSVRA--QAK---VCHYRVSMAADGSLYLQKGRLFPGLEE 192

Query: 229 LVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGT 288
           L+ YY  +   + + L   C   K   Q    D WE P     L  KLG+G FGEVW G 
Sbjct: 193 LLTYYKANWKLIQNPLLQPCMPQKAPRQ----DVWERPHSEFALGRKLGEGYFGEVWEGL 248

Query: 289 WNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKG 347
           W G+  VAIK +K   M      +E Q +K LRHE+L++L+AV S  EP+YIVTE M KG
Sbjct: 249 WLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKG 308

Query: 348 SLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVAD 407
           +L  FL    G+ LRLP L+  A Q+A GM+Y+E    VHRDL A N+LV + L CKVAD
Sbjct: 309 NLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVAD 368

Query: 408 FGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYP 467
           FGLARL++D+ Y+    +K P+KWTAPEAA Y  F+ KSDVWSFG+LL E+ T G+ PY 
Sbjct: 369 FGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYE 428

Query: 468 GMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQ 516
           GM N E L Q+ RGYR+P P  CP  ++ LM +CWR  PEERP+F  L+
Sbjct: 429 GMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLR 477


>gi|148596974 TXK tyrosine kinase [Homo sapiens]
          Length = 527

 Score =  328 bits (842), Expect = 6e-90
 Identities = 179/440 (40%), Positives = 263/440 (59%), Gaps = 16/440 (3%)

Query: 91  ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSD--SIQA 148
           ALYD+  R   +L+ ++ E   I+      WW A     G  G IPSNYV  +   +++ 
Sbjct: 89  ALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD-RLGNEGLIPSNYVTENKITNLEI 147

Query: 149 EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLN---VKHY 205
            EWY   ITR ++E LL   E+  G F+VR+S    G+Y +SV  F  A+      +KHY
Sbjct: 148 YEWYHRNITRNQAEHLL-RQESKEGAFIVRDSRHL-GSYTISV--FMGARRSTEAAIKHY 203

Query: 206 KIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRL---TTVCPTSKPQTQGLAKDA 262
           +I+K DSG +Y+  R  F S+ +L+ Y+  +A GL  RL     +  +  P T G + + 
Sbjct: 204 QIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEK 263

Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRH 322
           WEI    L    ++G G FG V +G W    +VAIK +  G+MS E F++EA+VM KL H
Sbjct: 264 WEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSH 323

Query: 323 EKLVQLYAV-VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381
            KLVQLY V +  +P+YIVTE+M  G LL++L+   GK LR   L+ +   I  GM Y+E
Sbjct: 324 SKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGK-LRKEMLLSVCQDICEGMEYLE 382

Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441
           R  Y+HRDL A N LV    + K++DFG+ R + D+EY +  GAKFPIKW+ PE  L+ +
Sbjct: 383 RNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNK 442

Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQC 501
           ++ KSDVWSFG+L+ E+ T+G++P+    N +V++ +  G+R+  P   P S++++M  C
Sbjct: 443 YSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSC 502

Query: 502 WRKEPEERPTF-EYLQAFLE 520
           W ++PE RPTF E L+A  E
Sbjct: 503 WHEKPEGRPTFAELLRAVTE 522


>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
          Length = 631

 Score =  322 bits (826), Expect = 4e-88
 Identities = 174/441 (39%), Positives = 266/441 (60%), Gaps = 13/441 (2%)

Query: 90  VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVA--PSDSIQ 147
           VA+YD+++    DL  ++G+   I+   +  WW A     G  GYIPSNYV    S+++ 
Sbjct: 185 VAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNNLD 243

Query: 148 AEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSV-SDFDNAKGLNVKHYK 206
             EWY   + R ++E+LL  +E+  G F+VR+S +  G Y +S+ + F        +HY 
Sbjct: 244 QYEWYCRNMNRSKAEQLL-RSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRHYH 301

Query: 207 IRKLDSGG--FYITSRTQFNSLQQLVAYYSKHADGLCHRL---TTVCPTSKPQTQGLAKD 261
           I++  +    +Y+  +  F S+ +++ Y+  +A GL  RL    +V   + P T G + +
Sbjct: 302 IKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYE 361

Query: 262 AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR 321
            WEI    L    +LG G FG V +G W    +VAIK ++ G M  E F++EA+VM KL 
Sbjct: 362 KWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLT 421

Query: 322 HEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380
           H KLVQLY V +++ PIYIVTE+M +G LL+FL+   G + R   L+ M   +  GM Y+
Sbjct: 422 HPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLSMCQDVCEGMEYL 480

Query: 381 ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 440
           ER +++HRDL A N LV E  V KV+DFG+AR + D++YT+  GAKFP+KW  PE   Y 
Sbjct: 481 ERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYS 540

Query: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQ 500
           RF+ KSDVWSFG+L+ E+ T+GR+P+    N EV+  V RG+R+  P      ++++M +
Sbjct: 541 RFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLR 600

Query: 501 CWRKEPEERPTFEYLQAFLED 521
           CW+++PE RP+FE L   +++
Sbjct: 601 CWQEKPEGRPSFEDLLRTIDE 621


>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
          Length = 659

 Score =  318 bits (816), Expect = 6e-87
 Identities = 184/496 (37%), Positives = 279/496 (56%), Gaps = 32/496 (6%)

Query: 40  KPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTT-----FVALYD 94
           KP S+  HR       P   E ++         +  P    P A  V+T      VALYD
Sbjct: 176 KPGSS--HRKTKKPLPPTPEEDQI---------LKKPLPPEPAAAPVSTSELKKVVALYD 224

Query: 95  YESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPS-DSIQAEEWYF 153
           Y      DL  +KG+   I+  +   WW A     GQ GYIPSNYV  + DSI+  EWY 
Sbjct: 225 YMPMNANDLQLRKGDEYFILEESNLPWWRARD-KNGQEGYIPSNYVTEAEDSIEMYEWYS 283

Query: 154 GKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSV--SDFDNAKGLNVKHYKIRKLD 211
             +TR ++E+LL   E   G F+VR+S    G Y +SV      + +G+ ++HY +    
Sbjct: 284 KHMTRSQAEQLL-KQEGKEGGFIVRDSSKA-GKYTVSVFAKSTGDPQGV-IRHYVVCSTP 340

Query: 212 SGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSK-----PQTQGLAKDAWEIP 266
              +Y+  +  F+++ +L+ Y+  ++ GL  RL    P S+     P T GL   +WEI 
Sbjct: 341 QSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKY--PVSQQNKNAPSTAGLGYGSWEID 398

Query: 267 RESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLV 326
            + L    +LG G FG V  G W G   VAIK +K G+MS + F++EA+VM  L HEKLV
Sbjct: 399 PKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLV 458

Query: 327 QLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385
           QLY V +++ PI+I+TEYM+ G LL++L+ E     +  QL++M   +   M Y+E   +
Sbjct: 459 QLYGVCTKQRPIFIITEYMANGCLLNYLR-EMRHRFQTQQLLEMCKDVCEAMEYLESKQF 517

Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 445
           +HRDL A N LV +  V KV+DFGL+R + D+EYT+  G+KFP++W+ PE  +Y +F+ K
Sbjct: 518 LHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSK 577

Query: 446 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKE 505
           SD+W+FG+L+ E+ + G++PY    N E  + + +G R+  P    E ++ +M  CW ++
Sbjct: 578 SDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEK 637

Query: 506 PEERPTFEYLQAFLED 521
            +ERPTF+ L + + D
Sbjct: 638 ADERPTFKILLSNILD 653


>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
          Length = 620

 Score =  305 bits (782), Expect = 5e-83
 Identities = 166/439 (37%), Positives = 255/439 (58%), Gaps = 14/439 (3%)

Query: 87  TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPS--D 144
           T  +ALYDY++    +L+ ++ E   +++++E  WW     + G  GY+PS+Y+     +
Sbjct: 174 TVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRN-GHEGYVPSSYLVEKSPN 232

Query: 145 SIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLN--V 202
           +++  EWY   I+R ++E+LLL+     G F+VR+S T  G Y +SV         N  +
Sbjct: 233 NLETYEWYNKSISRDKAEKLLLDT-GKEGAFMVRDSRTA-GTYTVSVFTKAVVSENNPCI 290

Query: 203 KHYKIRKLDSGG--FYITSRTQFNSLQQLVAYYSKHADGLCHRLT-TVC--PTSKPQTQG 257
           KHY I++ +     +Y+  +  F+S+  L+ Y+  +  GL  RL   VC      P T G
Sbjct: 291 KHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAG 350

Query: 258 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVM 317
           L    W I    L    ++G G FG V +G W    +VAIKT++ G MS E F++EA+VM
Sbjct: 351 LRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVM 410

Query: 318 KKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376
            KL H KLVQLY V  E+ PI +V E+M  G L D+L+ + G +     L+ M   +  G
Sbjct: 411 MKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAA-ETLLGMCLDVCEG 469

Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436
           MAY+E    +HRDL A N LVGEN V KV+DFG+ R + D++YT+  G KFP+KW +PE 
Sbjct: 470 MAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEV 529

Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496
             + R++ KSDVWSFG+L+ E+ ++G++PY    N EV++ +  G+R+  P      ++ 
Sbjct: 530 FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQ 589

Query: 497 LMCQCWRKEPEERPTFEYL 515
           +M  CW++ PE+RP F  L
Sbjct: 590 IMNHCWKERPEDRPAFSRL 608


>gi|187475373 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score =  294 bits (753), Expect = 1e-79
 Identities = 179/444 (40%), Positives = 250/444 (56%), Gaps = 24/444 (5%)

Query: 87  TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSI 146
           T  +A Y++    E DL F KG+ L IV  T+   W       G+ G IP+NYV   + +
Sbjct: 12  TECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGV 71

Query: 147 QAEE------WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGL 200
           +A        W+ GKITR ++ERLL   E   G FLVRES    G Y L VS      G 
Sbjct: 72  KAGTKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVS----CDG- 124

Query: 201 NVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTT--VCPTSKPQTQGL 258
            V+HY+I    +    I     F +L QLV +Y+  ADGLC RL    V   +       
Sbjct: 125 KVEHYRIM-YHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEF 183

Query: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMK 318
            +  W +  + L+L   +G+G FG+V +G + G  +VA+K +K    + +AFL EA VM 
Sbjct: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK-NDATAQAFLAEASVMT 241

Query: 319 KLRHEKLVQLYAVVSEEP--IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376
           +LRH  LVQL  V+ EE   +YIVTEYM+KGSL+D+L+      L    L+  +  +   
Sbjct: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301

Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436
           M Y+E  N+VHRDL A N+LV E+ V KV+DFGL +     + T     K P+KWTAPEA
Sbjct: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEA 357

Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496
               +F+ KSDVWSFGILL E+ + GRVPYP +  ++V+ +VE+GY+M  P  CP ++++
Sbjct: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYE 417

Query: 497 LMCQCWRKEPEERPTFEYLQAFLE 520
           +M  CW  +   RP+F  L+  LE
Sbjct: 418 VMKNCWHLDAAMRPSFLQLREQLE 441


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.133    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,964,093
Number of Sequences: 37866
Number of extensions: 1050091
Number of successful extensions: 5912
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 772
Number of HSP's successfully gapped in prelim test: 319
Number of HSP's that attempted gapping in prelim test: 3417
Number of HSP's gapped (non-prelim): 1434
length of query: 536
length of database: 18,247,518
effective HSP length: 107
effective length of query: 429
effective length of database: 14,195,856
effective search space: 6090022224
effective search space used: 6090022224
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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