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Search of human proteins with 47078233
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]
(504 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens] 1017 0.0
gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 941 0.0
gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 941 0.0
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens] 652 0.0
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens] 596 e-170
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens] 596 e-170
gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens] 370 e-102
gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens] 345 4e-95
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens] 329 4e-90
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens] 316 4e-86
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens] 314 1e-85
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens] 313 3e-85
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens] 311 1e-84
gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens] 247 2e-65
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens] 229 3e-60
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] 225 6e-59
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 224 1e-58
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 224 1e-58
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 224 1e-58
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 224 1e-58
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof... 224 1e-58
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 224 1e-58
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 223 3e-58
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 223 3e-58
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens] 216 3e-56
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens] 216 3e-56
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens] 215 9e-56
gi|223718134 cyclin-dependent kinase 6 [Homo sapiens] 211 1e-54
gi|4502741 cyclin-dependent kinase 6 [Homo sapiens] 211 1e-54
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2... 211 1e-54
>gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]
Length = 504
Score = 1017 bits (2630), Expect = 0.0
Identities = 504/504 (100%), Positives = 504/504 (100%)
Query: 1 MIMNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECST 60
MIMNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECST
Sbjct: 1 MIMNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECST 60
Query: 61 FSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEVRASGALPRQVAGCTHKGVHRRAAALQPD 120
FSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEVRASGALPRQVAGCTHKGVHRRAAALQPD
Sbjct: 61 FSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEVRASGALPRQVAGCTHKGVHRRAAALQPD 120
Query: 121 FDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKL 180
FDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKL
Sbjct: 121 FDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKL 180
Query: 181 GEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIH 240
GEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIH
Sbjct: 181 GEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIH 240
Query: 241 TDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQN 300
TDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQN
Sbjct: 241 TDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQN 300
Query: 301 LLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCI 360
LLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCI
Sbjct: 301 LLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCI 360
Query: 361 HYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINH 420
HYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINH
Sbjct: 361 HYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINH 420
Query: 421 APRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQ 480
APRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQ
Sbjct: 421 APRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQ 480
Query: 481 KDPGYRGLAFQQPGRGKNRRQSIF 504
KDPGYRGLAFQQPGRGKNRRQSIF
Sbjct: 481 KDPGYRGLAFQQPGRGKNRRQSIF 504
>gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 941 bits (2432), Expect = 0.0
Identities = 474/504 (94%), Positives = 474/504 (94%), Gaps = 30/504 (5%)
Query: 1 MIMNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECST 60
MIMNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECST
Sbjct: 1 MIMNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECST 60
Query: 61 FSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEVRASGALPRQVAGCTHKGVHRRAAALQPD 120
FSPTDSGEEPGQLSPGVQFQRRQNQRRFSME
Sbjct: 61 FSPTDSGEEPGQLSPGVQFQRRQNQRRFSME----------------------------- 91
Query: 121 FDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKL 180
DVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKL
Sbjct: 92 -DVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKL 150
Query: 181 GEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIH 240
GEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIH
Sbjct: 151 GEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIH 210
Query: 241 TDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQN 300
TDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQN
Sbjct: 211 TDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQN 270
Query: 301 LLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCI 360
LLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCI
Sbjct: 271 LLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCI 330
Query: 361 HYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINH 420
HYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINH
Sbjct: 331 HYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINH 390
Query: 421 APRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQ 480
APRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQ
Sbjct: 391 APRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQ 450
Query: 481 KDPGYRGLAFQQPGRGKNRRQSIF 504
KDPGYRGLAFQQPGRGKNRRQSIF
Sbjct: 451 KDPGYRGLAFQQPGRGKNRRQSIF 474
>gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 941 bits (2432), Expect = 0.0
Identities = 474/504 (94%), Positives = 474/504 (94%), Gaps = 30/504 (5%)
Query: 1 MIMNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECST 60
MIMNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECST
Sbjct: 1 MIMNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECST 60
Query: 61 FSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEVRASGALPRQVAGCTHKGVHRRAAALQPD 120
FSPTDSGEEPGQLSPGVQFQRRQNQRRFSME
Sbjct: 61 FSPTDSGEEPGQLSPGVQFQRRQNQRRFSME----------------------------- 91
Query: 121 FDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKL 180
DVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKL
Sbjct: 92 -DVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKL 150
Query: 181 GEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIH 240
GEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIH
Sbjct: 151 GEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIH 210
Query: 241 TDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQN 300
TDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQN
Sbjct: 211 TDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQN 270
Query: 301 LLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCI 360
LLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCI
Sbjct: 271 LLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCI 330
Query: 361 HYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINH 420
HYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINH
Sbjct: 331 HYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINH 390
Query: 421 APRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQ 480
APRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQ
Sbjct: 391 APRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQ 450
Query: 481 KDPGYRGLAFQQPGRGKNRRQSIF 504
KDPGYRGLAFQQPGRGKNRRQSIF
Sbjct: 451 KDPGYRGLAFQQPGRGKNRRQSIF 474
>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
Length = 523
Score = 652 bits (1681), Expect = 0.0
Identities = 335/526 (63%), Positives = 402/526 (76%), Gaps = 33/526 (6%)
Query: 6 MKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECSTFS--- 62
MK FKRR SL++ ++TI+ESL+E EQ N +N + GR PP S S
Sbjct: 1 MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGR-PPTSHSMHSFLH 59
Query: 63 -PTDSGEEPGQLSP--------GVQFQRRQNQRRFSM------------EVRASGALPRQ 101
T S ++P P G +N R + +ASG +
Sbjct: 60 QYTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDE 119
Query: 102 VAG----CTHKGVHRRAAALQPDFDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRM 157
V C +HRR + D++KRLSLP DIR+P +L+KLQ+ SP +P+SR
Sbjct: 120 VQSPTGVCLRNRIHRRISME----DLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRR 175
Query: 158 SRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTA 217
SRRASLS+IGFGK+ETY+KL+KLGEGTYATV+KGRSKLTENLVALKEIRLEHEEGAPCTA
Sbjct: 176 SRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTA 235
Query: 218 IREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMF 277
IREVSLLK+LKHANIVTLHD++HTD+SLTLVFEYLD DLKQY+D CGN+MSMHNVK+F++
Sbjct: 236 IREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLY 295
Query: 278 QLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYR 337
Q+LRGLAYCH RK+LHRDLKPQNLLINE+GELKLADFGLARAKSVPTKTYSNEVVTLWYR
Sbjct: 296 QILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYR 355
Query: 338 PPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPG 397
PPDVLLGS+EYST IDMWGVGCI +EMA+GRPLFPGSTV++ELHLIFRLLGTP++ETWPG
Sbjct: 356 PPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPG 415
Query: 398 VTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRS 457
+++ EF+ Y+FP Y PQPLINHAPRLD++GI L++ L YESK R+SAE A+ H YFRS
Sbjct: 416 ISSNEEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRS 475
Query: 458 LGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQQPGRGKNRRQSI 503
LG R+H L ++ SIFSLKEIQLQKDPG+R ++ + G GKNRRQS+
Sbjct: 476 LGPRIHALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGKNRRQSM 521
>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
Length = 502
Score = 596 bits (1536), Expect = e-170
Identities = 304/498 (61%), Positives = 372/498 (74%), Gaps = 17/498 (3%)
Query: 3 MNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQL----GPLGRDPPQEC 58
M++MK KR+ S+++ I+++ N E + L G G DP +
Sbjct: 7 MDRMKKIKRQLSMTLRGGRGIDKT------------NGAPEQIGLDESGGGGGSDPGEAP 54
Query: 59 STFSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEV-RASGALPRQVAGCTHKGVHRRAAAL 117
+ +P + G LS + + E +AS +V +
Sbjct: 55 TRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRK 114
Query: 118 QPDFDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKL 177
D++KRLSLP DIRLP+ +L+KL + SP KPLSR RR SLS+IGFGKLETY+KL
Sbjct: 115 ISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKL 174
Query: 178 DKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHD 237
DKLGEGTYATV+KG+SKLT+NLVALKEIRLEHEEGAPCTAIREVSLLK+LKHANIVTLHD
Sbjct: 175 DKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHD 234
Query: 238 LIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLK 297
+IHT++SLTLVFEYLD DLKQYLD CGN+++MHNVK+F+FQLLRGLAYCH +K+LHRDLK
Sbjct: 235 IIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLK 294
Query: 298 PQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGV 357
PQNLLINERGELKLADFGLARAKS+PTKTYSNEVVTLWYRPPD+LLGST+YST IDMWGV
Sbjct: 295 PQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGV 354
Query: 358 GCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPL 417
GCI YEMATGRPLFPGSTV+E+LH IFR+LGTPTEETWPG+ + EF+TY++P Y + L
Sbjct: 355 GCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEAL 414
Query: 418 INHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEI 477
++HAPRLD+DG LL+ LL +E ++R+SAE A+ H +F SLGER+H+L DT SIF+LKEI
Sbjct: 415 LSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEI 474
Query: 478 QLQKDPGYRGLAFQQPGR 495
QLQK+ R + GR
Sbjct: 475 QLQKEASLRSSSMPDSGR 492
>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
Length = 496
Score = 596 bits (1536), Expect = e-170
Identities = 304/498 (61%), Positives = 372/498 (74%), Gaps = 17/498 (3%)
Query: 3 MNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQL----GPLGRDPPQEC 58
M++MK KR+ S+++ I+++ N E + L G G DP +
Sbjct: 1 MDRMKKIKRQLSMTLRGGRGIDKT------------NGAPEQIGLDESGGGGGSDPGEAP 48
Query: 59 STFSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEV-RASGALPRQVAGCTHKGVHRRAAAL 117
+ +P + G LS + + E +AS +V +
Sbjct: 49 TRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRK 108
Query: 118 QPDFDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKL 177
D++KRLSLP DIRLP+ +L+KL + SP KPLSR RR SLS+IGFGKLETY+KL
Sbjct: 109 ISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKL 168
Query: 178 DKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHD 237
DKLGEGTYATV+KG+SKLT+NLVALKEIRLEHEEGAPCTAIREVSLLK+LKHANIVTLHD
Sbjct: 169 DKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHD 228
Query: 238 LIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLK 297
+IHT++SLTLVFEYLD DLKQYLD CGN+++MHNVK+F+FQLLRGLAYCH +K+LHRDLK
Sbjct: 229 IIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLK 288
Query: 298 PQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGV 357
PQNLLINERGELKLADFGLARAKS+PTKTYSNEVVTLWYRPPD+LLGST+YST IDMWGV
Sbjct: 289 PQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGV 348
Query: 358 GCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPL 417
GCI YEMATGRPLFPGSTV+E+LH IFR+LGTPTEETWPG+ + EF+TY++P Y + L
Sbjct: 349 GCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEAL 408
Query: 418 INHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEI 477
++HAPRLD+DG LL+ LL +E ++R+SAE A+ H +F SLGER+H+L DT SIF+LKEI
Sbjct: 409 LSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEI 468
Query: 478 QLQKDPGYRGLAFQQPGR 495
QLQK+ R + GR
Sbjct: 469 QLQKEASLRSSSMPDSGR 486
>gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
Length = 451
Score = 370 bits (949), Expect = e-102
Identities = 204/367 (55%), Positives = 250/367 (68%), Gaps = 23/367 (6%)
Query: 142 KLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVA 201
K + PK + R S +S + FGK ++Y KL+KLGEG+YATV+KG+SK+ LVA
Sbjct: 86 KTSSTGKESPK-VRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVA 144
Query: 202 LKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLD 261
LK IRL+ EEG P TAIRE SLLK LKHANIV LHD+IHT +LTLVFEY+ +DL QY+D
Sbjct: 145 LKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMD 204
Query: 262 HCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKS 321
+ NVK+F+FQLLRGL+Y H R ILHRDLKPQNLLI++ GELKLADFGLARAKS
Sbjct: 205 KHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKS 264
Query: 322 VPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPG-STVKEEL 380
VP+ TYSNEVVTLWYRPPDVLLGSTEYST +DMWGVGCI EM G FPG ++++L
Sbjct: 265 VPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQL 324
Query: 381 HLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPL---------INHAPRLDTDGIHL 431
IF +LGTP E+TWPGV + F+ F Y + L +NHA L
Sbjct: 325 ERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAE-------DL 377
Query: 432 LSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQ 491
S LL K+R+SA+AALSH YF L R+ +L D +SIF++ ++LQ + G AF
Sbjct: 378 ASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAF- 436
Query: 492 QPGRGKN 498
GKN
Sbjct: 437 ----GKN 439
>gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]
Length = 384
Score = 345 bits (886), Expect = 4e-95
Identities = 175/318 (55%), Positives = 227/318 (71%), Gaps = 3/318 (0%)
Query: 168 FGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNL 227
FG +Y+ L+KLGEG+YATV+KG S++ LVALK I + EEG P TAIRE SLLK L
Sbjct: 46 FGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGL 105
Query: 228 KHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCH 287
KHANIV LHD+IHT +LT VFEY+ +DL QY+ + HNV++FMFQLLRGLAY H
Sbjct: 106 KHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIH 165
Query: 288 HRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTE 347
H+ +LHRDLKPQNLLI+ GELKLADFGLARAKS+P++TYS+EVVTLWYRPPD LLG+TE
Sbjct: 166 HQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATE 225
Query: 348 YSTPIDMWGVGCIHYEMATGRPLFPG-STVKEELHLIFRLLGTPTEETWPGVTAFSEFRT 406
YS+ +D+WG GCI EM G+PLFPG S + E+L I+ +LG PTE+TWPGV+ +
Sbjct: 226 YSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNP 285
Query: 407 YSFPCYLPQPLINHAPRLD--TDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQ 464
FP P+ L RL + L S +L + R+SA+ AL H YF +L +++Q
Sbjct: 286 EWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQ 345
Query: 465 LEDTASIFSLKEIQLQKD 482
L D S+F++ ++L+ +
Sbjct: 346 LPDEESLFTVSGVRLKPE 363
>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
Length = 292
Score = 329 bits (843), Expect = 4e-90
Identities = 164/288 (56%), Positives = 205/288 (71%), Gaps = 5/288 (1%)
Query: 171 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKH 229
++ Y KL+K+GEGTY TVFK +++ T +VALK +RL+ + EG P +A+RE+ LLK LKH
Sbjct: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60
Query: 230 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHR 289
NIV LHD++H+D+ LTLVFE+ D DLK+Y D C + VK F+FQLL+GL +CH R
Sbjct: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120
Query: 290 KILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYS 349
+LHRDLKPQNLLIN GELKLADFGLARA +P + YS EVVTLWYRPPDVL G+ YS
Sbjct: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180
Query: 350 TPIDMWGVGCIHYEMA-TGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYS 408
T IDMW GCI E+A GRPLFPG+ V ++L IFRLLGTPTEE WP +T +++ Y
Sbjct: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY- 239
Query: 409 FPCY-LPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYF 455
P Y L+N P+L+ G LL +LL R+SAE AL H YF
Sbjct: 240 -PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286
>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
Length = 297
Score = 316 bits (809), Expect = 4e-86
Identities = 151/298 (50%), Positives = 212/298 (71%), Gaps = 4/298 (1%)
Query: 171 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLE-HEEGAPCTAIREVSLLKNLKH 229
+E Y K++K+GEGTY V+KGR K T +VA+K+IRLE EEG P TAIRE+SLLK L+H
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
Query: 230 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHC--GNLMSMHNVKIFMFQLLRGLAYCH 287
NIV+L D++ D L L+FE+L DLK+YLD G M VK +++Q+L+G+ +CH
Sbjct: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120
Query: 288 HRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTE 347
R++LHRDLKPQNLLI+++G +KLADFGLARA +P + Y++EVVTLWYR P+VLLGS
Sbjct: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180
Query: 348 YSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTY 407
YSTP+D+W +G I E+AT +PLF G + ++L IFR LGTP E WP V + +++
Sbjct: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN- 239
Query: 408 SFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQL 465
+FP + P L +H LD +G+ LLS +L+Y+ R+S + AL+H YF L ++ ++
Sbjct: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297
>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
Length = 297
Score = 314 bits (804), Expect = 1e-85
Identities = 149/298 (50%), Positives = 211/298 (70%), Gaps = 4/298 (1%)
Query: 171 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLE-HEEGAPCTAIREVSLLKNLKH 229
+E Y K++K+GEGTY V+KGR K T +VA+K+IRLE EEG P TAIRE+SLLK L+H
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
Query: 230 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHC--GNLMSMHNVKIFMFQLLRGLAYCH 287
NIV+L D++ D L L+FE+L DLK+YLD G M VK +++Q+L+G+ +CH
Sbjct: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120
Query: 288 HRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTE 347
R++LHRDLKPQNLLI+++G +KLADFGLARA +P + Y++E +TLWYR P+VLLGS
Sbjct: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEAITLWYRSPEVLLGSAR 180
Query: 348 YSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTY 407
YSTP+D+W +G I E+AT +PLF G + ++L IFR LGTP E WP V + +++
Sbjct: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN- 239
Query: 408 SFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQL 465
+FP + P L +H LD +G+ LLS +L+Y+ R+S + AL+H YF L ++ ++
Sbjct: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297
>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
Length = 305
Score = 313 bits (801), Expect = 3e-85
Identities = 152/289 (52%), Positives = 213/289 (73%), Gaps = 3/289 (1%)
Query: 171 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKH 229
++ + K++K+GEGTY V+K +++ T LVALK+IRL+ E EG P TAIRE+SLLK LKH
Sbjct: 1 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH 60
Query: 230 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHC-GNLMSMHNVKIFMFQLLRGLAYCHH 288
NIV L D++H +R L LVFE+L DLK+Y+D G+ + +H +K ++FQLL+G+++CH
Sbjct: 61 PNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHS 120
Query: 289 RKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEY 348
+++HRDLKPQNLLINE G +KLADFGLARA VP +TY++EVVTLWYR P++LLGS Y
Sbjct: 121 HRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFY 180
Query: 349 STPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYS 408
+T +D+W +GCI EM T + LFPG + ++L IFR+LGTP+E+TWPGVT +++ S
Sbjct: 181 TTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKG-S 239
Query: 409 FPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRS 457
FP + + L P L+ +G LL LL Y+ R++A+ AL+H YF S
Sbjct: 240 FPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSS 288
>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
Length = 298
Score = 311 bits (796), Expect = 1e-84
Identities = 158/297 (53%), Positives = 210/297 (70%), Gaps = 3/297 (1%)
Query: 171 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKH 229
+E + K++K+GEGTY V+K R+KLT +VALK+IRL+ E EG P TAIRE+SLLK L H
Sbjct: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
Query: 230 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNL-MSMHNVKIFMFQLLRGLAYCHH 288
NIV L D+IHT+ L LVFE+L DLK+++D + + +K ++FQLL+GLA+CH
Sbjct: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
Query: 289 RKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEY 348
++LHRDLKPQNLLIN G +KLADFGLARA VP +TY++EVVTLWYR P++LLG Y
Sbjct: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180
Query: 349 STPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYS 408
ST +D+W +GCI EM T R LFPG + ++L IFR LGTP E WPGVT+ +++ S
Sbjct: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 239
Query: 409 FPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQL 465
FP + Q P LD DG LLS +L Y+ R+SA+AAL+H +F+ + + V L
Sbjct: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 296
>gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens]
Length = 264
Score = 247 bits (631), Expect = 2e-65
Identities = 138/297 (46%), Positives = 185/297 (62%), Gaps = 37/297 (12%)
Query: 171 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKH 229
+E + K++K+GEGTY V+K R+KLT +VALK+IRL+ E EG P TAIRE+SLLK L H
Sbjct: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
Query: 230 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNL-MSMHNVKIFMFQLLRGLAYCHH 288
NIV L D+IHT+ L LVFE+L DLK+++D + + +K ++FQLL+GLA+CH
Sbjct: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
Query: 289 RKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEY 348
++LHRDLKPQNLLIN G +KLADFGLARA VP +TY++EV
Sbjct: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV----------------- 163
Query: 349 STPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYS 408
T R LFPG + ++L IFR LGTP E WPGVT+ +++ S
Sbjct: 164 -----------------TRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 205
Query: 409 FPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQL 465
FP + Q P LD DG LLS +L Y+ R+SA+AAL+H +F+ + + V L
Sbjct: 206 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 262
>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
Length = 360
Score = 229 bits (585), Expect = 3e-60
Identities = 130/328 (39%), Positives = 191/328 (58%), Gaps = 11/328 (3%)
Query: 132 DIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKG 191
D+ Q L+ ++ E P R+ R S+ + + KL+++GEGTY V++
Sbjct: 5 DLECEQIRLKCIRKEGFFTVPPEHRLGRCRSVKE--------FEKLNRIGEGTYGIVYRA 56
Query: 192 RSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKHANIVTLHDLIHTDR--SLTLV 248
R T+ +VALK++R++ E +G P +++RE++LL L+H NIV L +++ + S+ LV
Sbjct: 57 RDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLV 116
Query: 249 FEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGE 308
Y + DL L++ S VK + Q+LRGL Y H I+HRDLK NLL+ ++G
Sbjct: 117 MGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGC 176
Query: 309 LKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGR 368
+K ADFGLARA VP K + +VVTLWYR P++LLG+T +T IDMW VGCI E+ R
Sbjct: 177 VKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHR 236
Query: 369 PLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDG 428
PL PG++ ++ LI +LLGTP+E WPG + YS L + P L G
Sbjct: 237 PLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAG 296
Query: 429 IHLLSSLLLYESKSRMSAEAALSHSYFR 456
+ LL L +Y+ K R +A L SYF+
Sbjct: 297 LRLLHFLFMYDPKKRATAGDCLESSYFK 324
>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
Length = 346
Score = 225 bits (574), Expect = 6e-59
Identities = 119/291 (40%), Positives = 178/291 (61%), Gaps = 8/291 (2%)
Query: 170 KLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEH----EEGAPCTAIREVSLLK 225
+ + Y KLD LGEG +ATV+K R K T +VA+K+I+L H ++G TA+RE+ LL+
Sbjct: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67
Query: 226 NLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAY 285
L H NI+ L D +++LVF+++++DL+ + +++ ++K +M L+GL Y
Sbjct: 68 ELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127
Query: 286 CHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGS 345
H ILHRDLKP NLL++E G LKLADFGLA++ P + Y+++VVT WYR P++L G+
Sbjct: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187
Query: 346 TEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFR 405
Y +DMW VGCI E+ P PG + ++L IF LGTPTEE WP + + ++
Sbjct: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV 247
Query: 406 TY-SFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYF 455
T+ SFP PL + D + L+ L L+ +R++A AL YF
Sbjct: 248 TFKSFPGI---PLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 224 bits (572), Expect = 1e-58
Identities = 120/297 (40%), Positives = 175/297 (58%), Gaps = 10/297 (3%)
Query: 167 GFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 225
G +E + L+++ EGTY V++ + K T+ +VALK +++E E EG P T++RE++ +
Sbjct: 407 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 466
Query: 226 NLKHANIVTLHDLIHTDR--SLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGL 283
+H NIVT+ +++ + +V Y++ DLK ++ VK M QLLRG+
Sbjct: 467 KAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGV 526
Query: 284 AYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLL 343
+ H ILHRDLK NLL++ G LK+ DFGLAR P K Y+ VVTLWYR P++LL
Sbjct: 527 KHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLL 586
Query: 344 GSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSE 403
G+ EYST +DMW VGCI E+ T +PLFPG + ++++ +F+ LGTP+E+ WPG +SE
Sbjct: 587 GAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG---YSE 643
Query: 404 FRTYSFPCYLPQPLINHAPR----LDTDGIHLLSSLLLYESKSRMSAEAALSHSYFR 456
+ P N R L G L++ L Y R+SAE L H YFR
Sbjct: 644 LPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 700
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 224 bits (572), Expect = 1e-58
Identities = 120/297 (40%), Positives = 175/297 (58%), Gaps = 10/297 (3%)
Query: 167 GFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 225
G +E + L+++ EGTY V++ + K T+ +VALK +++E E EG P T++RE++ +
Sbjct: 416 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 475
Query: 226 NLKHANIVTLHDLIHTDR--SLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGL 283
+H NIVT+ +++ + +V Y++ DLK ++ VK M QLLRG+
Sbjct: 476 KAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGV 535
Query: 284 AYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLL 343
+ H ILHRDLK NLL++ G LK+ DFGLAR P K Y+ VVTLWYR P++LL
Sbjct: 536 KHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLL 595
Query: 344 GSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSE 403
G+ EYST +DMW VGCI E+ T +PLFPG + ++++ +F+ LGTP+E+ WPG +SE
Sbjct: 596 GAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG---YSE 652
Query: 404 FRTYSFPCYLPQPLINHAPR----LDTDGIHLLSSLLLYESKSRMSAEAALSHSYFR 456
+ P N R L G L++ L Y R+SAE L H YFR
Sbjct: 653 LPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 709
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 224 bits (572), Expect = 1e-58
Identities = 120/297 (40%), Positives = 175/297 (58%), Gaps = 10/297 (3%)
Query: 167 GFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 225
G +E + L+++ EGTY V++ + K T+ +VALK +++E E EG P T++RE++ +
Sbjct: 384 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 443
Query: 226 NLKHANIVTLHDLIHTDR--SLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGL 283
+H NIVT+ +++ + +V Y++ DLK ++ VK M QLLRG+
Sbjct: 444 KAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGV 503
Query: 284 AYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLL 343
+ H ILHRDLK NLL++ G LK+ DFGLAR P K Y+ VVTLWYR P++LL
Sbjct: 504 KHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLL 563
Query: 344 GSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSE 403
G+ EYST +DMW VGCI E+ T +PLFPG + ++++ +F+ LGTP+E+ WPG +SE
Sbjct: 564 GAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG---YSE 620
Query: 404 FRTYSFPCYLPQPLINHAPR----LDTDGIHLLSSLLLYESKSRMSAEAALSHSYFR 456
+ P N R L G L++ L Y R+SAE L H YFR
Sbjct: 621 LPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 677
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 224 bits (572), Expect = 1e-58
Identities = 120/297 (40%), Positives = 175/297 (58%), Gaps = 10/297 (3%)
Query: 167 GFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 225
G +E + L+++ EGTY V++ + K T+ +VALK +++E E EG P T++RE++ +
Sbjct: 373 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 432
Query: 226 NLKHANIVTLHDLIHTDR--SLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGL 283
+H NIVT+ +++ + +V Y++ DLK ++ VK M QLLRG+
Sbjct: 433 KAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGV 492
Query: 284 AYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLL 343
+ H ILHRDLK NLL++ G LK+ DFGLAR P K Y+ VVTLWYR P++LL
Sbjct: 493 KHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLL 552
Query: 344 GSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSE 403
G+ EYST +DMW VGCI E+ T +PLFPG + ++++ +F+ LGTP+E+ WPG +SE
Sbjct: 553 GAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG---YSE 609
Query: 404 FRTYSFPCYLPQPLINHAPR----LDTDGIHLLSSLLLYESKSRMSAEAALSHSYFR 456
+ P N R L G L++ L Y R+SAE L H YFR
Sbjct: 610 LPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 666
>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
3 [Homo sapiens]
Length = 526
Score = 224 bits (572), Expect = 1e-58
Identities = 120/297 (40%), Positives = 175/297 (58%), Gaps = 10/297 (3%)
Query: 167 GFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 225
G +E + L+++ EGTY V++ + K T+ +VALK +++E E EG P T++RE++ +
Sbjct: 162 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 221
Query: 226 NLKHANIVTLHDLIHTDR--SLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGL 283
+H NIVT+ +++ + +V Y++ DLK ++ VK M QLLRG+
Sbjct: 222 KAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGV 281
Query: 284 AYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLL 343
+ H ILHRDLK NLL++ G LK+ DFGLAR P K Y+ VVTLWYR P++LL
Sbjct: 282 KHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLL 341
Query: 344 GSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSE 403
G+ EYST +DMW VGCI E+ T +PLFPG + ++++ +F+ LGTP+E+ WPG +SE
Sbjct: 342 GAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG---YSE 398
Query: 404 FRTYSFPCYLPQPLINHAPR----LDTDGIHLLSSLLLYESKSRMSAEAALSHSYFR 456
+ P N R L G L++ L Y R+SAE L H YFR
Sbjct: 399 LPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 455
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 224 bits (572), Expect = 1e-58
Identities = 120/297 (40%), Positives = 175/297 (58%), Gaps = 10/297 (3%)
Query: 167 GFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 225
G +E + L+++ EGTY V++ + K T+ +VALK +++E E EG P T++RE++ +
Sbjct: 418 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 477
Query: 226 NLKHANIVTLHDLIHTDR--SLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGL 283
+H NIVT+ +++ + +V Y++ DLK ++ VK M QLLRG+
Sbjct: 478 KAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGV 537
Query: 284 AYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLL 343
+ H ILHRDLK NLL++ G LK+ DFGLAR P K Y+ VVTLWYR P++LL
Sbjct: 538 KHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLL 597
Query: 344 GSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSE 403
G+ EYST +DMW VGCI E+ T +PLFPG + ++++ +F+ LGTP+E+ WPG +SE
Sbjct: 598 GAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG---YSE 654
Query: 404 FRTYSFPCYLPQPLINHAPR----LDTDGIHLLSSLLLYESKSRMSAEAALSHSYFR 456
+ P N R L G L++ L Y R+SAE L H YFR
Sbjct: 655 LPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 711
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 223 bits (568), Expect = 3e-58
Identities = 119/297 (40%), Positives = 175/297 (58%), Gaps = 10/297 (3%)
Query: 167 GFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 225
G +E + L+++ EGTY V++ + K T+ +VALK +++E E EG P T++RE++ +
Sbjct: 406 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 465
Query: 226 NLKHANIVTLHDLIHTDR--SLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGL 283
+H NIVT+ +++ + +V Y++ DLK ++ VK M QLLRG+
Sbjct: 466 KAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGV 525
Query: 284 AYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLL 343
+ H ILHRDLK NLL++ G LK+ DFGLAR P K Y+ VVT WYR P++LL
Sbjct: 526 KHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLL 585
Query: 344 GSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSE 403
G+ EYST +DMW VGCI E+ T +PLFPG++ ++++ +F+ LGTP+E+ WPG +SE
Sbjct: 586 GAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPG---YSE 642
Query: 404 FRTYSFPCYLPQPLINHAPR----LDTDGIHLLSSLLLYESKSRMSAEAALSHSYFR 456
+ P N R L G L++ L Y R+SAE L H YFR
Sbjct: 643 LPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 699
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 223 bits (568), Expect = 3e-58
Identities = 119/297 (40%), Positives = 175/297 (58%), Gaps = 10/297 (3%)
Query: 167 GFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 225
G +E + L+++ EGTY V++ + K T+ +VALK +++E E EG P T++RE++ +
Sbjct: 416 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 475
Query: 226 NLKHANIVTLHDLIHTDR--SLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGL 283
+H NIVT+ +++ + +V Y++ DLK ++ VK M QLLRG+
Sbjct: 476 KAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGV 535
Query: 284 AYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLL 343
+ H ILHRDLK NLL++ G LK+ DFGLAR P K Y+ VVT WYR P++LL
Sbjct: 536 KHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLL 595
Query: 344 GSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSE 403
G+ EYST +DMW VGCI E+ T +PLFPG++ ++++ +F+ LGTP+E+ WPG +SE
Sbjct: 596 GAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPG---YSE 652
Query: 404 FRTYSFPCYLPQPLINHAPR----LDTDGIHLLSSLLLYESKSRMSAEAALSHSYFR 456
+ P N R L G L++ L Y R+SAE L H YFR
Sbjct: 653 LPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 709
>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
Length = 1512
Score = 216 bits (551), Expect = 3e-56
Identities = 130/367 (35%), Positives = 197/367 (53%), Gaps = 17/367 (4%)
Query: 108 KGVHRRAAALQPDFDVSKRLSLPMDI-RLPQEFLQKLQMESPDLPKPLSRMSRRASLSDI 166
K V ++ L D + L D+ + P+E Q+ S PK DI
Sbjct: 636 KEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYGETKEKDI 695
Query: 167 GFGK--LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSL 223
+GK ++ + + +GEGTY V+K R K T +VALK++RL++E EG P TAIRE+ +
Sbjct: 696 DWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKI 755
Query: 224 LKNLKHANIVTLHDLIHTDR-----------SLTLVFEYLDSDLKQYLDHCGNLMSMHNV 272
L+ L H +I+ + +++ TD+ + LVFEY+D DL L+ + +++
Sbjct: 756 LRQLTHQSIINMKEIV-TDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHI 814
Query: 273 KIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARA-KSVPTKTYSNEV 331
K FM QL+ GL YCH + LHRD+K N+L+N RG++KLADFGLAR S ++ Y+N+V
Sbjct: 815 KSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKV 874
Query: 332 VTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPT 391
+TLWYRPP++LLG Y+ ID+W GCI E+ T +P+F + +L LI R+ G+P
Sbjct: 875 ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPC 934
Query: 392 EETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALS 451
WP V F T + L + + L +L + R +AE AL
Sbjct: 935 PAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQ 994
Query: 452 HSYFRSL 458
+ R +
Sbjct: 995 CEFLRDV 1001
>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
Length = 1452
Score = 216 bits (551), Expect = 3e-56
Identities = 130/367 (35%), Positives = 197/367 (53%), Gaps = 17/367 (4%)
Query: 108 KGVHRRAAALQPDFDVSKRLSLPMDI-RLPQEFLQKLQMESPDLPKPLSRMSRRASLSDI 166
K V ++ L D + L D+ + P+E Q+ S PK DI
Sbjct: 636 KEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYGETKEKDI 695
Query: 167 GFGK--LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSL 223
+GK ++ + + +GEGTY V+K R K T +VALK++RL++E EG P TAIRE+ +
Sbjct: 696 DWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKI 755
Query: 224 LKNLKHANIVTLHDLIHTDR-----------SLTLVFEYLDSDLKQYLDHCGNLMSMHNV 272
L+ L H +I+ + +++ TD+ + LVFEY+D DL L+ + +++
Sbjct: 756 LRQLTHQSIINMKEIV-TDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHI 814
Query: 273 KIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARA-KSVPTKTYSNEV 331
K FM QL+ GL YCH + LHRD+K N+L+N RG++KLADFGLAR S ++ Y+N+V
Sbjct: 815 KSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKV 874
Query: 332 VTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPT 391
+TLWYRPP++LLG Y+ ID+W GCI E+ T +P+F + +L LI R+ G+P
Sbjct: 875 ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPC 934
Query: 392 EETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALS 451
WP V F T + L + + L +L + R +AE AL
Sbjct: 935 PAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQ 994
Query: 452 HSYFRSL 458
+ R +
Sbjct: 995 CEFLRDV 1001
>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
Length = 346
Score = 215 bits (547), Expect = 9e-56
Identities = 111/288 (38%), Positives = 168/288 (58%), Gaps = 3/288 (1%)
Query: 171 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEH-EEGAPCTAIREVSLLKNLK- 228
++ Y L ++GEG + VFK + T +VALK++ L E+G P A+RE+ L+ ++
Sbjct: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60
Query: 229 HANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHH 288
+ +V L + L FE++ SDL + + H ++ VK ++ LL+G+A+CH
Sbjct: 61 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHA 120
Query: 289 RKILHRDLKPQNLLINERGELKLADFGLARAKSVP-TKTYSNEVVTLWYRPPDVLLGSTE 347
I+HRDLKP NLLI+ G+LK+ADFGLAR S ++ Y+++V T WYR P++L G+ +
Sbjct: 121 NNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGARQ 180
Query: 348 YSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTY 407
Y +D+W VGCI E+ G PLFPG E+L + R+LGTP + WP +T ++
Sbjct: 181 YDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKI 240
Query: 408 SFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYF 455
SF +P PL P + + LL LLY R++A AL H YF
Sbjct: 241 SFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF 288
>gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]
Length = 326
Score = 211 bits (537), Expect = 1e-54
Identities = 130/298 (43%), Positives = 177/298 (59%), Gaps = 16/298 (5%)
Query: 172 ETYVKLDKLGEGTYATVFKGRS-KLTENLVALKEIRLEH-EEGAPCTAIREVSLLKNLK- 228
+ Y + ++GEG Y VFK R K VALK +R++ EEG P + IREV++L++L+
Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70
Query: 229 --HANIVTLHDLI---HTDRS--LTLVFEYLDSDLKQYLDHCGNL-MSMHNVKIFMFQLL 280
H N+V L D+ TDR LTLVFE++D DL YLD + +K MFQLL
Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130
Query: 281 RGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPD 340
RGL + H +++HRDLKPQN+L+ G++KLADFGLAR S ++ VVTLWYR P+
Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF-QMALTSVVVTLWYRAPE 189
Query: 341 VLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTA 400
VLL S+ Y+TP+D+W VGCI EM +PLF GS+ ++L I ++G P EE WP A
Sbjct: 190 VLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248
Query: 401 FSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSL 458
+F QP+ +D G LL L + R+SA +ALSH YF+ L
Sbjct: 249 LPR---QAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303
>gi|4502741 cyclin-dependent kinase 6 [Homo sapiens]
Length = 326
Score = 211 bits (537), Expect = 1e-54
Identities = 130/298 (43%), Positives = 177/298 (59%), Gaps = 16/298 (5%)
Query: 172 ETYVKLDKLGEGTYATVFKGRS-KLTENLVALKEIRLEH-EEGAPCTAIREVSLLKNLK- 228
+ Y + ++GEG Y VFK R K VALK +R++ EEG P + IREV++L++L+
Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70
Query: 229 --HANIVTLHDLI---HTDRS--LTLVFEYLDSDLKQYLDHCGNL-MSMHNVKIFMFQLL 280
H N+V L D+ TDR LTLVFE++D DL YLD + +K MFQLL
Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130
Query: 281 RGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPD 340
RGL + H +++HRDLKPQN+L+ G++KLADFGLAR S ++ VVTLWYR P+
Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF-QMALTSVVVTLWYRAPE 189
Query: 341 VLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTA 400
VLL S+ Y+TP+D+W VGCI EM +PLF GS+ ++L I ++G P EE WP A
Sbjct: 190 VLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248
Query: 401 FSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSL 458
+F QP+ +D G LL L + R+SA +ALSH YF+ L
Sbjct: 249 LPR---QAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303
>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
[Homo sapiens]
Length = 1481
Score = 211 bits (537), Expect = 1e-54
Identities = 119/313 (38%), Positives = 178/313 (56%), Gaps = 14/313 (4%)
Query: 159 RRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTA 217
RR + SD G ++ + + +GEGTY V+K + K T LVALK++RL++E EG P TA
Sbjct: 712 RRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITA 771
Query: 218 IREVSLLKNLKHANIVTLHDLIHTDR-----------SLTLVFEYLDSDLKQYLDHCGNL 266
IRE+ +L+ L H ++V + +++ TD+ + LVFEY+D DL L+
Sbjct: 772 IREIKILRQLIHRSVVNMKEIV-TDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVH 830
Query: 267 MSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARA-KSVPTK 325
S ++K FM QL+ GL YCH + LHRD+K N+L+N G++KLADFGLAR S ++
Sbjct: 831 FSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESR 890
Query: 326 TYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFR 385
Y+N+V+TLWYRPP++LLG Y+ ID+W GCI E+ T +P+F + +L LI R
Sbjct: 891 PYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISR 950
Query: 386 LLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMS 445
L G+P WP V F T + L + + + LL +L + R +
Sbjct: 951 LCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCT 1010
Query: 446 AEAALSHSYFRSL 458
AE L + + +
Sbjct: 1011 AEQTLQSDFLKDV 1023
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,895,039
Number of Sequences: 37866
Number of extensions: 960298
Number of successful extensions: 4464
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 728
Number of HSP's successfully gapped in prelim test: 67
Number of HSP's that attempted gapping in prelim test: 2375
Number of HSP's gapped (non-prelim): 923
length of query: 504
length of database: 18,247,518
effective HSP length: 107
effective length of query: 397
effective length of database: 14,195,856
effective search space: 5635754832
effective search space used: 5635754832
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.