Guide to the Human Genome
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Search of human proteins with 46909598

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|46909598 a disintegrin and metalloproteinase domain 15
isoform 5 preproprotein [Homo sapiens]
         (862 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|46909598 a disintegrin and metalloproteinase domain 15 isofor...  1823   0.0  
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor...  1818   0.0  
gi|46909594 a disintegrin and metalloproteinase domain 15 isofor...  1735   0.0  
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor...  1713   0.0  
gi|46909590 a disintegrin and metalloproteinase domain 15 isofor...  1678   0.0  
gi|46909592 a disintegrin and metalloproteinase domain 15 isofor...  1560   0.0  
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot...   543   e-154
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro...   516   e-146
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ...   516   e-146
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot...   508   e-144
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop...   479   e-135
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H...   426   e-119
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]   399   e-111
gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot...   392   e-109
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ...   313   3e-85
gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprot...   313   4e-85
gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot...   313   6e-85
gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprot...   313   6e-85
gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprot...   313   6e-85
gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprot...   313   6e-85
gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprote...   313   6e-85
gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo s...   312   7e-85
gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo s...   295   1e-79
gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo ...   288   1e-77
gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ...   286   6e-77
gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo ...   285   1e-76
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo...   273   4e-73
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo...   273   4e-73
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo...   273   4e-73
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ...   273   4e-73

>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
           preproprotein [Homo sapiens]
          Length = 862

 Score = 1823 bits (4721), Expect = 0.0
 Identities = 862/862 (100%), Positives = 862/862 (100%)

Query: 1   MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV 60
           MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
Sbjct: 1   MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV 60

Query: 61  LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ 120
           LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
Sbjct: 61  LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ 120

Query: 121 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA 180
           GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
Sbjct: 121 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA 180

Query: 181 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL 240
           LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
Sbjct: 181 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL 240

Query: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300
           EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
Sbjct: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300

Query: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360
           AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
Sbjct: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360

Query: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM 420
           PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM 420

Query: 421 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480
           AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
Sbjct: 421 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480

Query: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540
           RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
Sbjct: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540

Query: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600
           PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
Sbjct: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600

Query: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK 660
           ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
Sbjct: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK 660

Query: 661 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720
           CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
Sbjct: 661 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720

Query: 721 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKASALSFPAPPSRPLPPDPVSK 780
           LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKASALSFPAPPSRPLPPDPVSK
Sbjct: 721 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKASALSFPAPPSRPLPPDPVSK 780

Query: 781 RLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAG 840
           RLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAG
Sbjct: 781 RLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAG 840

Query: 841 IPPLVVPSRPAPPPPTVSSLYL 862
           IPPLVVPSRPAPPPPTVSSLYL
Sbjct: 841 IPPLVVPSRPAPPPPTVSSLYL 862


>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
           preproprotein [Homo sapiens]
          Length = 863

 Score = 1818 bits (4709), Expect = 0.0
 Identities = 862/863 (99%), Positives = 862/863 (99%), Gaps = 1/863 (0%)

Query: 1   MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV 60
           MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
Sbjct: 1   MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV 60

Query: 61  LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ 120
           LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
Sbjct: 61  LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ 120

Query: 121 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA 180
           GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
Sbjct: 121 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA 180

Query: 181 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL 240
           LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
Sbjct: 181 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL 240

Query: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300
           EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
Sbjct: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300

Query: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360
           AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
Sbjct: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360

Query: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM 420
           PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM 420

Query: 421 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480
           AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
Sbjct: 421 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480

Query: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540
           RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
Sbjct: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540

Query: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600
           PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
Sbjct: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600

Query: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK 660
           ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
Sbjct: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK 660

Query: 661 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720
           CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
Sbjct: 661 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720

Query: 721 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK-ASALSFPAPPSRPLPPDPVS 779
           LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK ASALSFPAPPSRPLPPDPVS
Sbjct: 721 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKQASALSFPAPPSRPLPPDPVS 780

Query: 780 KRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGA 839
           KRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGA
Sbjct: 781 KRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGA 840

Query: 840 GIPPLVVPSRPAPPPPTVSSLYL 862
           GIPPLVVPSRPAPPPPTVSSLYL
Sbjct: 841 GIPPLVVPSRPAPPPPTVSSLYL 863


>gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3
           preproprotein [Homo sapiens]
          Length = 839

 Score = 1735 bits (4494), Expect = 0.0
 Identities = 829/863 (96%), Positives = 833/863 (96%), Gaps = 25/863 (2%)

Query: 1   MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV 60
           MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
Sbjct: 1   MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV 60

Query: 61  LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ 120
           LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
Sbjct: 61  LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ 120

Query: 121 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA 180
           GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
Sbjct: 121 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA 180

Query: 181 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL 240
           LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
Sbjct: 181 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL 240

Query: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300
           EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
Sbjct: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300

Query: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360
           AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
Sbjct: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360

Query: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM 420
           PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM 420

Query: 421 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480
           AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
Sbjct: 421 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480

Query: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540
           RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
Sbjct: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540

Query: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600
           PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
Sbjct: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600

Query: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK 660
           ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
Sbjct: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK 660

Query: 661 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720
           CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
Sbjct: 661 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720

Query: 721 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK-ASALSFPAPPSRPLPPDPVS 779
           LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK ASALSFPAPPSRPLPPDPVS
Sbjct: 721 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKQASALSFPAPPSRPLPPDPVS 780

Query: 780 KRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGA 839
           KRLQ++   +P PP +PLPA                        DPQGRCPSGDLPGPGA
Sbjct: 781 KRLQSQGPAKPPPPRKPLPA------------------------DPQGRCPSGDLPGPGA 816

Query: 840 GIPPLVVPSRPAPPPPTVSSLYL 862
           GIPPLVVPSRPAPPPPTVSSLYL
Sbjct: 817 GIPPLVVPSRPAPPPPTVSSLYL 839


>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
           preproprotein [Homo sapiens]
          Length = 838

 Score = 1713 bits (4436), Expect = 0.0
 Identities = 816/862 (94%), Positives = 823/862 (95%), Gaps = 24/862 (2%)

Query: 1   MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV 60
           MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
Sbjct: 1   MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV 60

Query: 61  LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ 120
           LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
Sbjct: 61  LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ 120

Query: 121 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA 180
           GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
Sbjct: 121 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA 180

Query: 181 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL 240
           LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
Sbjct: 181 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL 240

Query: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300
           EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
Sbjct: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300

Query: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360
           AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
Sbjct: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360

Query: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM 420
           PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM 420

Query: 421 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480
           AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
Sbjct: 421 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480

Query: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540
           RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
Sbjct: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540

Query: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600
           PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
Sbjct: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600

Query: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK 660
           ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
Sbjct: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK 660

Query: 661 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720
           CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
Sbjct: 661 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720

Query: 721 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKASALSFPAPPSRPLPPDPVSK 780
           LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKA     P PP+RPLP DPV +
Sbjct: 721 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKAELADRPNPPTRPLPADPVVR 780

Query: 781 RLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAG 840
             +++   +P PP +PLPA                        DPQGRCPSGDLPGPGAG
Sbjct: 781 SPKSQGPAKPPPPRKPLPA------------------------DPQGRCPSGDLPGPGAG 816

Query: 841 IPPLVVPSRPAPPPPTVSSLYL 862
           IPPLVVPSRPAPPPPTVSSLYL
Sbjct: 817 IPPLVVPSRPAPPPPTVSSLYL 838


>gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2
           preproprotein [Homo sapiens]
          Length = 814

 Score = 1678 bits (4345), Expect = 0.0
 Identities = 805/862 (93%), Positives = 808/862 (93%), Gaps = 48/862 (5%)

Query: 1   MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV 60
           MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
Sbjct: 1   MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV 60

Query: 61  LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ 120
           LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
Sbjct: 61  LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ 120

Query: 121 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA 180
           GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
Sbjct: 121 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA 180

Query: 181 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL 240
           LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
Sbjct: 181 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL 240

Query: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300
           EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
Sbjct: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300

Query: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360
           AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
Sbjct: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360

Query: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM 420
           PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM 420

Query: 421 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480
           AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
Sbjct: 421 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480

Query: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540
           RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
Sbjct: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540

Query: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600
           PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
Sbjct: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600

Query: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK 660
           ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
Sbjct: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK 660

Query: 661 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720
           CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
Sbjct: 661 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720

Query: 721 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKASALSFPAPPSRPLPPDPVSK 780
           LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK+   + P PP +         
Sbjct: 721 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKSQGPAKPPPPRK--------- 771

Query: 781 RLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAG 840
                               P                   LPADPQGRCPSGDLPGPGAG
Sbjct: 772 --------------------P-------------------LPADPQGRCPSGDLPGPGAG 792

Query: 841 IPPLVVPSRPAPPPPTVSSLYL 862
           IPPLVVPSRPAPPPPTVSSLYL
Sbjct: 793 IPPLVVPSRPAPPPPTVSSLYL 814


>gi|46909592 a disintegrin and metalloproteinase domain 15 isoform 1
           preproprotein [Homo sapiens]
          Length = 772

 Score = 1560 bits (4039), Expect = 0.0
 Identities = 738/746 (98%), Positives = 740/746 (99%), Gaps = 1/746 (0%)

Query: 1   MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV 60
           MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
Sbjct: 1   MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV 60

Query: 61  LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ 120
           LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
Sbjct: 61  LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ 120

Query: 121 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA 180
           GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
Sbjct: 121 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA 180

Query: 181 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL 240
           LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
Sbjct: 181 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL 240

Query: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300
           EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
Sbjct: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300

Query: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360
           AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
Sbjct: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360

Query: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM 420
           PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM 420

Query: 421 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480
           AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
Sbjct: 421 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480

Query: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540
           RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
Sbjct: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540

Query: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600
           PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
Sbjct: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600

Query: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK 660
           ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
Sbjct: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK 660

Query: 661 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720
           CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
Sbjct: 661 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720

Query: 721 LHQRLCQLKGPTCQYRAAQSGPSERP 746
           LHQRLCQLKGPTCQY + +  PS  P
Sbjct: 721 LHQRLCQLKGPTCQY-SLRGQPSPHP 745


>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
           [Homo sapiens]
          Length = 909

 Score =  543 bits (1400), Expect = e-154
 Identities = 332/874 (37%), Positives = 458/874 (52%), Gaps = 78/874 (8%)

Query: 42  EPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQ 101
           E +   V   DL I +K     + PE L I+L+ +    I+ L +N  L+    T   Y 
Sbjct: 41  EVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYL 100

Query: 102 PDGTRV-VSEGHT--LENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPG 158
            DGT V ++  +T  L +C Y G VRGY+ S VS+ TCSGLRGL+V   E SY LE    
Sbjct: 101 QDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENE-SYVLEPMKS 159

Query: 159 DLQGPPIISRIQDLHLPGHTCALSWRESVHTQK----PPEHPLGQRHIRRRRDVVTETKT 214
                 +    +   + G +C           K    PP     +RH   +R+ +  TK 
Sbjct: 160 ATNRYKLFPAKKLKSVRG-SCGSHHNTPNLAAKNVFPPPSQTWARRH---KRETLKATKY 215

Query: 215 VELVIVADHSEAQKY-RDFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEI 273
           VELVIVAD+ E Q+  +D + +  R +E+A  +D F+RPLN+R+ LVG+E W   D   +
Sbjct: 216 VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSV 275

Query: 274 SPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNM 333
           S +P  +L  FL WR+  LLPR  HD+AQLV+G  F G T+GMA   S+C+ D SGG+ M
Sbjct: 276 SQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVM 335

Query: 334 DHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNC 393
           DHS + LG A ++AHELGH+ G++HD     C C        CIM AST +   + FS+C
Sbjct: 336 DHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSC 395

Query: 394 SRRALEKALLDGMGSCLFERLPSLPPM--AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSL 451
           SR+ LE +L  GMG CLF  LP +        CGN FVE GE+CDCG  ++C++ CC++ 
Sbjct: 396 SRKDLETSLEKGMGVCLF-NLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNAT 454

Query: 452 TCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEP 511
           TC L+P A CA  G CC++CQL+P+G  CR +   CDLPEFC G S  CP +V L DG  
Sbjct: 455 TCTLKPDAVCA-HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHS 513

Query: 512 CAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSC 571
           C      C +G C ++ QQC +LWGPGA+PA  +C +  N+ G+ +G+CG+    S+  C
Sbjct: 514 CQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKC 573

Query: 572 TPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTL 630
             RDA CG++QCQ G ++P++G+    +   I +  G  + C   H+ LG D+  P L L
Sbjct: 574 EMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVL 633

Query: 631 PGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDC------ 684
            GT C  G +C++ +CQ + + G  EC  +CHG GVC++ ++C+CE  WAPP C      
Sbjct: 634 AGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFG 693

Query: 685 ------TTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRARLHQRLCQLKGPT------ 732
                   +      LT G+L+++L LL    +   Y  R  L + L   K  T      
Sbjct: 694 GSTDSGPIRQADNQGLTIGILVTILCLLAAGFV--VYLKRKTLIRLLFTNKKTTIEKLRC 751

Query: 733 ------------CQYRAAQSG-------PSERP--GPPQRALLARGTKAS----ALSFPA 767
                       CQ      G       P   P    P+R L  +    S     L+ P 
Sbjct: 752 VRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSYPPKDNPRRLLQCQNVDISRPLNGLNVPQ 811

Query: 768 PPS--RPLPPDPVSKRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADP 825
           P S  R LPP   + R        P+ P RPLPA P +R  ++QG  KP PP+KPLPADP
Sbjct: 812 PQSTQRVLPPLHRAPR-------APSVPARPLPAKPALR--QAQGTCKPNPPQKPLPADP 862

Query: 826 QG---RCPSGDLPGPGAGIPPL-VVPSRPAPPPP 855
                R        PG     L + P RPAP  P
Sbjct: 863 LARTTRLTHALARTPGQWETGLRLAPLRPAPQYP 896


>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
           preproprotein [Homo sapiens]
          Length = 813

 Score =  516 bits (1330), Expect = e-146
 Identities = 321/810 (39%), Positives = 423/810 (52%), Gaps = 44/810 (5%)

Query: 21  WPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLP---ISLKKVLQTSLPEPLRIKLELDG 77
           WP+P  G  +         P +P+ P  + D  P   +SL++ +  S P+   + LE +G
Sbjct: 23  WPVPGAGVLQGH------IPGQPVTPHWVLDGQPWRTVSLEEPV--SKPDMGLVALEAEG 74

Query: 78  DSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCS 137
              +LEL +N  L+        Y PDG  VV   +  ++C YQGRVRG+  SWV +CTCS
Sbjct: 75  QELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCS 134

Query: 138 GLRGLVVLTPERSYTLE----QGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKPP 193
           G+ GL+ L+   SY L     +G  D     I    Q L   G TC    R+  +     
Sbjct: 135 GMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKG-TCG--HRDPGNKAGMT 191

Query: 194 EHPLGQRHIRRRRDVVTETKTVELVIVADHSE-AQKYRDFQHLLNRTLEVALLLDTFFRP 252
             P G +  R RR+     K +EL IVADH+    ++R+  H   R LEVA  +D   R 
Sbjct: 192 SLPGGPQS-RGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRT 250

Query: 253 LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGP 312
           L+++VAL GLE WT+RD   ++ +   TL  FL WRR  L  + PHDSAQL+TG +F G 
Sbjct: 251 LDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRG-LWAQRPHDSAQLLTGRAFQGA 309

Query: 313 TVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAP 372
           TVG+A    +C  + SGGV+ DHS   +G A+++AHE+GHSLGL HD  G  C     A 
Sbjct: 310 TVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDG--CCVEAAAE 367

Query: 373 AKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERL-PSLPPMAAFCGNMFVEP 431
           +  C+M A+T       FS CSRR L      G G+CL     P LP   A CGN FVE 
Sbjct: 368 SGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEA 427

Query: 432 GEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPE 491
           GE+CDCG   +C D CC +  C LRPGAQCA  G CC  C L+P+G  CR   GDCDLPE
Sbjct: 428 GEECDCGPGQECRDLCCFAHNCSLRPGAQCAH-GDCCVRCLLKPAGALCRQAMGDCDLPE 486

Query: 492 FCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTAN 551
           FC G SS CPPDV L DG PCA G   C  G C +  QQCQ LWGPG+ PA   C Q  N
Sbjct: 487 FCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVN 546

Query: 552 TRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVNGTELN 611
           + G+A G+CG++  G ++ C  RDA+CG+LQCQ G+   LL      +  T+ ++G E+ 
Sbjct: 547 SAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPS-LLAPHMVPVDSTVHLDGQEVT 605

Query: 612 CSWVHLDLGS---DVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCD 668
           C    L L S   D+    L  PGT CGP +VC   RC++      Q C + CH HGVC+
Sbjct: 606 CRGA-LALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCN 664

Query: 669 SNRHCYCEEGWAPPDC----------TTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYR 718
           SN +C+C  GWAPP C          +  ++A +  T  L + L VLL L+      W  
Sbjct: 665 SNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCC 724

Query: 719 ARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKASALSFPAPPSRPLPPDPV 778
            RL     Q     C+   A SGP +    P R     G     L  P    +P P DP 
Sbjct: 725 YRLPGAHLQRCSWGCRRDPACSGPKD---GPHRDHPLGGVHPMELG-PTATGQPWPLDPE 780

Query: 779 SKRLQAELADRPNPPTRPLPADPVVRSPKS 808
           +    +   ++P P   P P    V+ P+S
Sbjct: 781 NSHEPSSHPEKPLPAVSPDPQADQVQMPRS 810


>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
           sapiens]
          Length = 918

 Score =  516 bits (1328), Expect = e-146
 Identities = 313/880 (35%), Positives = 458/880 (52%), Gaps = 91/880 (10%)

Query: 27  GGTEEQQAESEKAPREPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQ 86
           G T   +  S K   E + PQ    + P+  K  L+  L      ++  +G   IL+L +
Sbjct: 29  GWTRGSEEGSPKLQHELIIPQWKTSESPVREKHPLKAEL------RVMAEGRELILDLEK 82

Query: 87  NRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLT 146
           N +L     T   Y   G    +     ++C Y G VR    S V++ TC G+RGL+ ++
Sbjct: 83  NEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVTLSTCRGIRGLITVS 142

Query: 147 PERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESV-------HTQKPPEHPLGQ 199
              SY +E  P D +G  +I R + L  P   C     +          TQ+  + P   
Sbjct: 143 SNLSYVIEPLP-DSKGQHLIYRSEHLKPPPGNCGFEHSKPTTRDWALQFTQQTKKRPR-- 199

Query: 200 RHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVALLLDTFFRPLNVRVA 258
              R +R+ +   K VEL +VAD+ E QK R D     ++ +E+A  +D F+R LN+R+A
Sbjct: 200 ---RMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDKFYRSLNIRIA 256

Query: 259 LVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAI 318
           LVGLE WT  ++ E+S NP  TL +FL WRR  LL +  HD+AQL+TG SF G T+G+A 
Sbjct: 257 LVGLEVWTHGNMCEVSENPYSTLWSFLSWRRK-LLAQKYHDNAQLITGMSFHGTTIGLAP 315

Query: 319 QNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIM 378
             ++CS   SGGVNMDHS + +GVA+++AHE+GH+ G+ HD   ++  C   A    CIM
Sbjct: 316 LMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHD---SADCCSASAADGGCIM 372

Query: 379 EASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM--AAFCGNMFVEPGEQCD 436
            A+T       F+ C+RR L++ L  G G CL   +P    +     CGN ++E GE+CD
Sbjct: 373 AAATGHPFPKVFNGCNRRELDRYLQSGGGMCL-SNMPDTRMLYGGRRCGNGYLEDGEECD 431

Query: 437 CGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGD 496
           CG  ++C +PCC++  C LRPGA+CA  G CC  C+L   G  CR     CDLPEFC G 
Sbjct: 432 CGEEEECNNPCCNASNCTLRPGAECAH-GSCCHQCKLLAPGTLCREQARQCDLPEFCTGK 490

Query: 497 SSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNA 556
           S  CP +    DG PC GGQA C +G C +Y +QCQ LWGPGA+PA  LC +  N  G+ 
Sbjct: 491 SPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVNVAGDT 550

Query: 557 FGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVNGTELNCSWVH 616
           FG+CG++ +G +  C  RDA CG++QCQ+   +PL  +   +   TI +NG ++ C   H
Sbjct: 551 FGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPID-TTIIMNGRQIQCRGTH 609

Query: 617 LDLG----SDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRH 672
           +  G     D+  P L + GT CG   +C + +C+       + C  KC+GHGVC++N++
Sbjct: 610 VYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHGVCNNNQN 669

Query: 673 CYCEEGWAPPDCTTQ------------LKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720
           C+C  GWAPP C T              ++   +  G+L+++LVL VL+++    +Y  R
Sbjct: 670 CHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLM----YYCCR 725

Query: 721 LHQRLCQLKGP----------TCQYRAAQSGPSERPGPPQRALLARGTKASALSFPA--- 767
            + +L QLK            +C +R +Q+  +    P  +    +G K   ++ P    
Sbjct: 726 QNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQG-KRKVINTPEILR 784

Query: 768 ----PPSRP--------LPPDPVSKRLQAELADRPNPPT---------RPLPADPVVRSP 806
               PP RP         PP P+   L     + P P +         RP P+ P+  +P
Sbjct: 785 KPSQPPPRPPPDYLRGGSPPAPLPAHLSRAARNSPGPGSQIERTESSRRPPPSRPIPPAP 844

Query: 807 K---SQGPAKPPPPRKPLPADP-QGRCPSGDLPGPGAGIP 842
               SQ  ++P PP+K LPA+P  GR     LP PG   P
Sbjct: 845 NCIVSQDFSRPRPPQKALPANPVPGR---RSLPRPGGASP 881


>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
           [Homo sapiens]
          Length = 738

 Score =  508 bits (1309), Expect = e-144
 Identities = 269/654 (41%), Positives = 378/654 (57%), Gaps = 18/654 (2%)

Query: 42  EPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQ 101
           E +   V   DL I +K     + PE L I+L+ +    I+ L +N  L+    T   Y 
Sbjct: 41  EVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYL 100

Query: 102 PDGTRV-VSEGHT--LENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPG 158
            DGT V ++  +T  L +C Y G VRGY+ S VS+ TCSGLRGL+V   E SY LE    
Sbjct: 101 QDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENE-SYVLEPMKS 159

Query: 159 DLQGPPIISRIQDLHLPGHTCALSWRESVHTQK----PPEHPLGQRHIRRRRDVVTETKT 214
                 +    +   + G +C           K    PP     +RH   +R+ +  TK 
Sbjct: 160 ATNRYKLFPAKKLKSVRG-SCGSHHNTPNLAAKNVFPPPSQTWARRH---KRETLKATKY 215

Query: 215 VELVIVADHSEAQKY-RDFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEI 273
           VELVIVAD+ E Q+  +D + +  R +E+A  +D F+RPLN+R+ LVG+E W   D   +
Sbjct: 216 VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSV 275

Query: 274 SPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNM 333
           S +P  +L  FL WR+  LLPR  HD+AQLV+G  F G T+GMA   S+C+ D SGG+ M
Sbjct: 276 SQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVM 335

Query: 334 DHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNC 393
           DHS + LG A ++AHELGH+ G++HD     C C        CIM AST +   + FS+C
Sbjct: 336 DHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSC 395

Query: 394 SRRALEKALLDGMGSCLFERLPSLPPM--AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSL 451
           SR+ LE +L  GMG CLF  LP +        CGN FVE GE+CDCG  ++C++ CC++ 
Sbjct: 396 SRKDLETSLEKGMGVCLF-NLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNAT 454

Query: 452 TCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEP 511
           TC L+P A CA  G CC++CQL+P+G  CR +   CDLPEFC G S  CP +V L DG  
Sbjct: 455 TCTLKPDAVCA-HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHS 513

Query: 512 CAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSC 571
           C      C +G C ++ QQC +LWGPGA+PA  +C +  N+ G+ +G+CG+    S+  C
Sbjct: 514 CQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKC 573

Query: 572 TPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTL 630
             RDA CG++QCQ G ++P++G+    +   I +  G  + C   H+ LG D+  P L L
Sbjct: 574 EMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVL 633

Query: 631 PGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDC 684
            GT C  G +C++ +CQ + + G  EC  +CHG GVC++ ++C+CE  WAPP C
Sbjct: 634 AGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFC 687


>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
           preproprotein [Homo sapiens]
          Length = 787

 Score =  479 bits (1233), Expect = e-135
 Identities = 311/810 (38%), Positives = 410/810 (50%), Gaps = 70/810 (8%)

Query: 21  WPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLP---ISLKKVLQTSLPEPLRIKLELDG 77
           WP+P  G  +         P +P+ P  + D  P   +SL++ +  S P+   + LE +G
Sbjct: 23  WPVPGAGVLQGH------IPGQPVTPHWVLDGQPWRTVSLEEPV--SKPDMGLVALEAEG 74

Query: 78  DSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCS 137
              +LEL +N  L+        Y PDG  VV   +  ++C YQGRVRG+  SWV +CTCS
Sbjct: 75  QELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCS 134

Query: 138 GLRGLVVLTPERSYTLE----QGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKPP 193
           G+ GL+ L+   SY L     +G  D     I    Q L   G TC    R+  +     
Sbjct: 135 GMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKG-TCG--HRDPGNKAGMT 191

Query: 194 EHPLGQRHIRRRRDVVTETKTVELVIVADHSE-AQKYRDFQHLLNRTLEVALLLDTFFRP 252
             P G +  R RR+     K +EL IVADH+    ++R+  H   R LEVA  +D   R 
Sbjct: 192 SLPGGPQS-RGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRT 250

Query: 253 LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGP 312
           L+++VAL GLE WT+RD   ++ +   TL  FL WRR  L  + PHDSAQL+TG +F G 
Sbjct: 251 LDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRG-LWAQRPHDSAQLLTGRAFQGA 309

Query: 313 TVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAP 372
           TVG+A    +C  + SGGV+ DHS   +G A+++AHE+GHSLGL HD  G  C     A 
Sbjct: 310 TVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDG--CCVEAAAE 367

Query: 373 AKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERL-PSLPPMAAFCGNMFVEP 431
           +  C+M A+T       FS CSRR L      G G+CL     P LP   A CGN FVE 
Sbjct: 368 SGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEA 427

Query: 432 GEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPE 491
           GE+CDCG   +C D CC +  C LRPGAQCA  G CC  C L+P+G  CR   GDCDLPE
Sbjct: 428 GEECDCGPGQECRDLCCFAHNCSLRPGAQCAH-GDCCVRCLLKPAGALCRQAMGDCDLPE 486

Query: 492 FCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTAN 551
           FC G SS CPPDV L DG PCA G   C  G C +  QQCQ LWGPG+ PA   C Q  N
Sbjct: 487 FCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVN 546

Query: 552 TRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVNGTELN 611
           + G+A G+CG++  G ++ C  RDA+CG+LQCQ G+   LL      +  T+ ++G E+ 
Sbjct: 547 SAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPS-LLAPHMVPVDSTVHLDGQEVT 605

Query: 612 CSWVHLDLGS---DVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCD 668
           C    L L S   D+    L  PGT CGP +                          VC+
Sbjct: 606 CRGA-LALPSAQLDLLGLGLVEPGTQCGPRM--------------------------VCN 638

Query: 669 SNRHCYCEEGWAPPDC----------TTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYR 718
           SN +C+C  GWAPP C          +  ++A +  T  L + L VLL L+      W  
Sbjct: 639 SNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCC 698

Query: 719 ARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKASALSFPAPPSRPLPPDPV 778
            RL     Q     C+   A SGP +    P R     G     L  P    +P P DP 
Sbjct: 699 YRLPGAHLQRCSWGCRRDPACSGPKD---GPHRDHPLGGVHPMELG-PTATGQPWPLDPE 754

Query: 779 SKRLQAELADRPNPPTRPLPADPVVRSPKS 808
           +    +   ++P P   P P    V+ P+S
Sbjct: 755 NSHEPSSHPEKPLPAVSPDPQADQVQMPRS 784


>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
           sapiens]
          Length = 819

 Score =  426 bits (1095), Expect = e-119
 Identities = 270/810 (33%), Positives = 406/810 (50%), Gaps = 83/810 (10%)

Query: 73  LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132
           ++ +G  HI+ L +N++L+P    +  Y  +GT +    +   +C Y+G V G   S ++
Sbjct: 70  IQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIA 129

Query: 133 ICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRE---SVHT 189
           +  C GLRGL+ L    SY +E          II R+ D++     C +S ++       
Sbjct: 130 LSDCFGLRGLLHLE-NASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKETAK 188

Query: 190 QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLLNRTLEVALLLDT 248
            +  E P   + +RRRR V+ +T+ VEL IV D        R+   +    + +A  LD+
Sbjct: 189 DEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLDS 248

Query: 249 FFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTS 308
            +  LN+R+ LVGLE WT  +L+ I       L NF+ WR   L+ R  HDSAQLV    
Sbjct: 249 MYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKG 308

Query: 309 FSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCP 368
           F G T GMA   ++CS   +GG+N+    ++   AS +AHELGH+LG++HD  G  C C 
Sbjct: 309 FGG-TAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHD-DGRDCSCG 366

Query: 369 GPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFE-RLPSLPPMAAFCGNM 427
               AK+CIM +        NFS+CS    EK  L+  G+CL     P     A  CGN 
Sbjct: 367 ----AKSCIMNSGAS--GSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNK 420

Query: 428 FVEPGEQCDCGFLDDC-VDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGD 486
            V+ GE+CDCG   +C +DPCC+  TC+L+  A+CA  G CC++C+  P G  CR    +
Sbjct: 421 LVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAY-GDCCKDCRFLPGGTLCRGKTSE 479

Query: 487 CDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLC 546
           CD+PE+C G S  C PDV + +G PC   +A C +G C  Y  QCQ ++G  A+ A   C
Sbjct: 480 CDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDC 539

Query: 547 LQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVN 606
               N++G+ FG+CG +    Y  C   +A+CG+LQC+  +  P+ G +  ++       
Sbjct: 540 FIEVNSKGDRFGNCGFS-GNEYKKCATGNALCGKLQCENVQEIPVFGIVPAII--QTPSR 596

Query: 607 GTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQ-ECRSKCHGHG 665
           GT+  C  V   LGSDV  P +   GT CG G +C + +C    +L    + + KCHGHG
Sbjct: 597 GTK--CWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHG 654

Query: 666 VCDSNRHCYCEEGWAPPDCTTQ------------LKATSSLTTGLLLSLLVLLVLVMLGA 713
           VC+SN++C+CE GWAPP+C T+             +  ++L  GLL+   +++ L++   
Sbjct: 655 VCNSNKNCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAI 714

Query: 714 SYWYRARLHQRLCQLKGPTCQYRAA---QSGPSERPGPPQRALLARGTKASALSFPAPPS 770
             + +     R    K  +  Y +    Q+ PS +PG   R +            P  P 
Sbjct: 715 FIFIKRDQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHVS-----------PVTPP 763

Query: 771 RPLPPDPVSKRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRCP 830
           R +P            A+R   PT         + P+ Q P++PPPP+  + +  QG   
Sbjct: 764 REVPI----------YANRFAVPTY------AAKQPQ-QFPSRPPPPQPKVSS--QGN-- 802

Query: 831 SGDLPGPGAGIPPLVVPSRPAPPPPTVSSL 860
                         ++P+RPAP PP  SSL
Sbjct: 803 --------------LIPARPAPAPPLYSSL 818


>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
          Length = 856

 Score =  399 bits (1025), Expect = e-111
 Identities = 283/812 (34%), Positives = 390/812 (48%), Gaps = 89/812 (10%)

Query: 66  PEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRG 125
           PE +   L   G +  L L +NR+L+    T  +   +G+ V  +    ++C YQG V G
Sbjct: 54  PERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEG 113

Query: 126 YAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRE 185
           Y  S  S+ TC+GLRG   +  +         G   G   + + + L     TC +S  +
Sbjct: 114 YPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVS-DD 172

Query: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALL 245
           S+ +   P      R          ET+ VEL +V D++E Q       + +R LEV   
Sbjct: 173 SLGSLLGPRTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNH 232

Query: 246 LDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVT 305
           +D  ++ LN RV LVGLE W  +D   +SP+P+VTLEN L W+      R  HD+ QL+T
Sbjct: 233 VDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLIT 292

Query: 306 GTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSC 365
           G  F+G TVG A  +++CS   SG VN DHS + +GVA ++AHE+GH+LG+DHD     C
Sbjct: 293 GVDFTGTTVGFARVSAMCSHS-SGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGC 351

Query: 366 PCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMAA--F 423
            C     A  CIM  S        FS+CS+  LE  L      CL    P L  +     
Sbjct: 352 RCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCL-ANAPDLSHLVGGPV 410

Query: 424 CGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPT 483
           CGN+FVE GEQCDCG  +DC + CC+S TCQL  GAQCA  G CCQ C+++P+G  CRP 
Sbjct: 411 CGNLFVERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCA-HGTCCQECKVKPAGELCRPK 469

Query: 484 RGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAA 543
           +  CDL EFC G   +CP D    +G PC+GG   C +G C + AQQCQ+ WGPG Q A 
Sbjct: 470 KDMCDLEEFCDGRHPECPEDAFQENGTPCSGG--YCYNGACPTLAQQCQAFWGPGGQAAE 527

Query: 544 PLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETI 603
             C        +    C    +  Y     R  +CG LQC+ G+ QPL  +I       +
Sbjct: 528 ESCFSY-----DILPGC---KASRY-----RADMCGVLQCKGGQ-QPLGRAIC-----IV 568

Query: 604 DVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHG 663
           DV      C  +  + G+   +P+    GT CGP  VC   RCQ + +  +  C ++CH 
Sbjct: 569 DV------CHALTTEDGT-AYEPV--PEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQCHN 619

Query: 664 HGVCDSNRHCYCEEGWAPPDCT---TQLKATSSLTTGLLLSLLVLLVLVML---GASYWY 717
           HGVC+  + C+C  GWAPP C    T++ A S      ++ +LVLL +V++   G   + 
Sbjct: 620 HGVCNHKQECHCHAGWAPPHCAKLLTEVHAASGSLPVFVVVVLVLLAVVLVTLAGIIVYR 679

Query: 718 RAR--------------------LHQRLCQL--KG--PTCQYRAAQSGPSERPGPPQRAL 753
           +AR                     HQ   ++  KG  P       +  P+  PG P R  
Sbjct: 680 KARSRILSRNVAPKTTMGRSNPLFHQAASRVPAKGGAPAPSRGPQELVPTTHPGQPARH- 738

Query: 754 LARGTKASALSFPAPP---SRPLPPDPVSKRLQAELADRPN--PPTRPLPADPVVRSPKS 808
               + A     PAPP   S P  P PV  R   +   +P   PP  P+       +P  
Sbjct: 739 -PASSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTFAPPVPPVKPGAGAANP-- 795

Query: 809 QGPA----------KPPPPRK---PLPADPQG 827
            GPA          KPP  RK    LP  P+G
Sbjct: 796 -GPAEGAVGPKVALKPPIQRKQGAELPQHPRG 826


>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
           [Homo sapiens]
          Length = 775

 Score =  392 bits (1007), Expect = e-109
 Identities = 230/658 (34%), Positives = 338/658 (51%), Gaps = 31/658 (4%)

Query: 62  QTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQG 121
           Q      L+ K+ ++G   +L L +N+ L+    T  +Y   G  + +    +++C YQG
Sbjct: 50  QEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQG 109

Query: 122 RVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGP--GDLQGPPIISRIQDLHLPGHTC 179
            +     S  SI TC GLRG      +R +     P   D Q   +     D      TC
Sbjct: 110 HILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTC 169

Query: 180 ALSWRESVHT-QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQ-HLLN 237
            +      H  Q+    P  +    + R V    K +E  +V D+ E ++Y + Q  +  
Sbjct: 170 GMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRK 229

Query: 238 RTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297
           R  E+A  ++  ++ LN  VALVG+E WT +D ++I+PN + TLENF  WR + L  R  
Sbjct: 230 RVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKR 289

Query: 298 HDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLD 357
           HD AQL+T T  +G TVG+A  +++CSP +S GV  DHS ++L VA ++AHE+GH+ G+ 
Sbjct: 290 HDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVVQDHSDNLLRVAGTMAHEMGHNFGMF 348

Query: 358 HDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPS 416
           HD    SC CP    +  C+M+ +  F    +FS+CSR + +K   D + +CLF   LP+
Sbjct: 349 HD--DYSCKCP----STICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPT 402

Query: 417 LPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPS 476
                  CGN  VE GE CDCG  ++C + CCD+ TC+++   QCA  G CC+ CQ + +
Sbjct: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCAL-GECCEKCQFKKA 461

Query: 477 GWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWG 536
           G  CRP + +CDLPE C G S  CP D    +G PC  G+  C+ G C +  +QC  LWG
Sbjct: 462 GMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWG 521

Query: 537 PGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIR 596
           PG + A   C    N  G+ +G C R    + + C   D +CG+L CQ        G   
Sbjct: 522 PGTEVADKSC-YNRNEGGSKYGYC-RRVDDTLIPCKANDTMCGKLFCQ--------GGSD 571

Query: 597 DLLWETIDVNGTELNCSWVHLDLGSDVAQPL-LTLPGTACGPGLVCIDHRCQRVD-LLGA 654
           +L W+   V  T L C     +   D +Q + +   GT CG   VCI+  C  ++    +
Sbjct: 572 NLPWKGRIV--TFLTCKTFDPE---DTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKS 626

Query: 655 QECRSKCHGHGVCDSNRHCYCEEGWAPPDC-TTQLKATSSLTTGLLLSLLVLLVLVML 711
             C SKC GH VCD    C CEEGW PPDC  + +    S+  G+L  + V+ V+V +
Sbjct: 627 TNCSSKCKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVGVLFPMAVIFVVVAM 684


>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
           sapiens]
          Length = 754

 Score =  313 bits (803), Expect = 3e-85
 Identities = 208/684 (30%), Positives = 327/684 (47%), Gaps = 33/684 (4%)

Query: 67  EPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGY 126
           E L  +++L+  + +L LL++RE +    +  +Y   G         +++C YQG +   
Sbjct: 57  EELLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHE 116

Query: 127 AGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRES 186
             S  SI TC+GLRG   +  +R Y +E      +G  ++ +  +L +P +    S  E 
Sbjct: 117 YDSAASISTCNGLRGFFRINDQR-YLIEPVKYSDEGEHLVFKY-NLRVP-YGANYSCTEL 173

Query: 187 VHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLLNRTLEVALL 245
             T+K            + + +  E K VEL IVAD +  ++       L NR   +   
Sbjct: 174 NFTRKTVPGDNESEEDSKIKGIHDE-KYVELFIVADDTVYRRNGHPHNKLRNRIWGMVNF 232

Query: 246 LDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVT 305
           ++  ++ LN+ V LVG+E WT  D +E+  N   TL  F  W+   L  R   D   L++
Sbjct: 233 VNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLLS 292

Query: 306 GTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSC 365
           G        G++    +C P +S  +  D       +A+ +AH+LGH+LG+ HD      
Sbjct: 293 GKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHD----EF 348

Query: 366 PCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFE-RLPSLPPMAAFC 424
           PC    P+  C+M+ S   +P L FS CS+    + L D   +C+     P       FC
Sbjct: 349 PCT--CPSGKCVMD-SDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFC 405

Query: 425 GNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTR 484
           GN  ++ GE+CDCG   +C +PCCD+ TC L+PG  CA +G CC++CQ++ +G  CRP +
Sbjct: 406 GNKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCA-EGECCESCQIKKAGSICRPAK 464

Query: 485 GDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAP 544
            +CD PE C G S  CP D    +G PC   +  C  G+C +   QC  L+   A  +  
Sbjct: 465 DECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHD 524

Query: 545 LCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETID 604
           +C +  NT+GN FG C +N    ++ C  +D  CG++ C  G    LLG  +    +   
Sbjct: 525 ICYK-MNTKGNKFGYC-KNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQ 582

Query: 605 VNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVD-LLGAQECRSKCHG 663
            N T + C  +   L  D     L   GT CG G+VC +  C  ++ +  +  C S+C+ 
Sbjct: 583 KNAT-VKCKTIF--LYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNE 639

Query: 664 HGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRARLHQ 723
           + V      C+CEEG AP  C   L  T+      +  L+V+LVLV++G         ++
Sbjct: 640 NPVDGHGLQCHCEEGQAPVACEETLHVTN------ITILVVVLVLVIVGIGVLILLVRYR 693

Query: 724 RLCQLKGPTCQYRAAQSGPSERPG 747
           +  +LK         QS P+E  G
Sbjct: 694 KCIKLK-------QVQSPPTETLG 710


>gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprotein
           [Homo sapiens]
          Length = 540

 Score =  313 bits (802), Expect = 4e-85
 Identities = 174/482 (36%), Positives = 257/482 (53%), Gaps = 13/482 (2%)

Query: 62  QTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQG 121
           Q      L+ K+ ++G   +L L +N+ L+    T  +Y   G  + +    +++C YQG
Sbjct: 50  QEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQG 109

Query: 122 RVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGP--GDLQGPPIISRIQDLHLPGHTC 179
            +     S  SI TC GLRG      +R +     P   D Q   +     D      TC
Sbjct: 110 HILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTC 169

Query: 180 ALSWRESVHT-QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQ-HLLN 237
            +      H  Q+    P  +    + R V    K +E  +V D+ E ++Y + Q  +  
Sbjct: 170 GMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRK 229

Query: 238 RTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297
           R  E+A  ++  ++ LN  VALVG+E WT +D ++I+PN + TLENF  WR + L  R  
Sbjct: 230 RVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKR 289

Query: 298 HDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLD 357
           HD AQL+T T  +G TVG+A  +++CSP +S GV  DHS ++L VA ++AHE+GH+ G+ 
Sbjct: 290 HDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVVQDHSDNLLRVAGTMAHEMGHNFGMF 348

Query: 358 HDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPS 416
           HD    SC C    P+  C+M+ +  F    +FS+CSR + +K   D + +CLF   LP+
Sbjct: 349 HD--DYSCKC----PSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPT 402

Query: 417 LPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPS 476
                  CGN  VE GE CDCG  ++C + CCD+ TC+++   QCA  G CC+ CQ + +
Sbjct: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCAL-GECCEKCQFKKA 461

Query: 477 GWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWG 536
           G  CRP + +CDLPE C G S  CP D    +G PC  G+  C+ G C +  +QC  LWG
Sbjct: 462 GMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWG 521

Query: 537 PG 538
           PG
Sbjct: 522 PG 523


>gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein
           [Homo sapiens]
          Length = 906

 Score =  313 bits (801), Expect = 6e-85
 Identities = 212/652 (32%), Positives = 306/652 (46%), Gaps = 47/652 (7%)

Query: 77  GDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTC 136
           G S IL+++ N +L+         +  G  V  +G   E+C YQG +RG   S+V++ TC
Sbjct: 97  GTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNPDSFVALSTC 154

Query: 137 SGLRGLV-------VLTPERSYTLEQGPGDLQGPPII-SRIQDLHL---PGHTCALSWRE 185
            GL G+        ++ PE + T ++   D     +  SR+ +  L   P     ++   
Sbjct: 155 HGLHGMFYDGNHTYLIEPEENDTTQE---DFHFHSVYKSRLFEFSLDDLPSEFQQVNITP 211

Query: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVAL 244
           S    KP      ++  R  R+V  ETK +EL+IV DH   +K+R    H       V  
Sbjct: 212 SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVN 271

Query: 245 LLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQL 303
           + D  ++  L  R+ LV +E W   +   IS NP +TL  F+ +RR  +  +   D+  L
Sbjct: 272 MADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK--SDAVHL 329

Query: 304 VTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHD---L 360
            +G+ F     G A    ICS    GGVN    T ++ V  ++A  L H++G+  D   L
Sbjct: 330 FSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAHNIGIISDKRKL 387

Query: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL--P 418
               C C        CIM  +  +LP   F+ C+       L  G G+CLF +   L  P
Sbjct: 388 ASGECKCEDTWSG--CIMGDTGYYLPK-KFTQCNIEEYHDFLNSGGGACLFNKPSKLLDP 444

Query: 419 PMAAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLRPGAQCASDGPCCQNCQLRP 475
           P    CGN F+E GE+CDCG   +CV     CC    C L   +QC SDG CC+ C+ +P
Sbjct: 445 PE---CGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQC-SDGLCCKKCKFQP 498

Query: 476 SGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLW 535
            G  CR    DCD+ E C G+SSQC P++   DG  C G Q +C  GRC +  +QC+ +W
Sbjct: 499 MGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIW 558

Query: 536 GPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSI 595
           G     +   C +  N  G   G+CG++   +++ C  RD +CG L C      P LG +
Sbjct: 559 GQKVTASDKYCYEKLNIEGTEKGNCGKD-KDTWIQCNKRDVLCGYLLCTNIGNIPRLGEL 617

Query: 596 RDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654
              +  T+ V  G  LNCS  H+ L  DV    +   GT CGP ++C++HRC  V     
Sbjct: 618 DGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVE-DGTPCGPQMMCLEHRCLPVASFNF 676

Query: 655 QECRSK-----CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLS 701
             C S      C G+GVC +   C C   W   DC T         TG+ LS
Sbjct: 677 STCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728


>gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprotein
           [Homo sapiens]
          Length = 899

 Score =  313 bits (801), Expect = 6e-85
 Identities = 212/652 (32%), Positives = 306/652 (46%), Gaps = 47/652 (7%)

Query: 77  GDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTC 136
           G S IL+++ N +L+         +  G  V  +G   E+C YQG +RG   S+V++ TC
Sbjct: 97  GTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNPDSFVALSTC 154

Query: 137 SGLRGLV-------VLTPERSYTLEQGPGDLQGPPII-SRIQDLHL---PGHTCALSWRE 185
            GL G+        ++ PE + T ++   D     +  SR+ +  L   P     ++   
Sbjct: 155 HGLHGMFYDGNHTYLIEPEENDTTQE---DFHFHSVYKSRLFEFSLDDLPSEFQQVNITP 211

Query: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVAL 244
           S    KP      ++  R  R+V  ETK +EL+IV DH   +K+R    H       V  
Sbjct: 212 SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVN 271

Query: 245 LLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQL 303
           + D  ++  L  R+ LV +E W   +   IS NP +TL  F+ +RR  +  +   D+  L
Sbjct: 272 MADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK--SDAVHL 329

Query: 304 VTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHD---L 360
            +G+ F     G A    ICS    GGVN    T ++ V  ++A  L H++G+  D   L
Sbjct: 330 FSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAHNIGIISDKRKL 387

Query: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL--P 418
               C C        CIM  +  +LP   F+ C+       L  G G+CLF +   L  P
Sbjct: 388 ASGECKCEDTWSG--CIMGDTGYYLPK-KFTQCNIEEYHDFLNSGGGACLFNKPSKLLDP 444

Query: 419 PMAAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLRPGAQCASDGPCCQNCQLRP 475
           P    CGN F+E GE+CDCG   +CV     CC    C L   +QC SDG CC+ C+ +P
Sbjct: 445 PE---CGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQC-SDGLCCKKCKFQP 498

Query: 476 SGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLW 535
            G  CR    DCD+ E C G+SSQC P++   DG  C G Q +C  GRC +  +QC+ +W
Sbjct: 499 MGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIW 558

Query: 536 GPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSI 595
           G     +   C +  N  G   G+CG++   +++ C  RD +CG L C      P LG +
Sbjct: 559 GQKVTASDKYCYEKLNIEGTEKGNCGKD-KDTWIQCNKRDVLCGYLLCTNIGNIPRLGEL 617

Query: 596 RDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654
              +  T+ V  G  LNCS  H+ L  DV    +   GT CGP ++C++HRC  V     
Sbjct: 618 DGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVE-DGTPCGPQMMCLEHRCLPVASFNF 676

Query: 655 QECRSK-----CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLS 701
             C S      C G+GVC +   C C   W   DC T         TG+ LS
Sbjct: 677 STCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728


>gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprotein
           [Homo sapiens]
          Length = 823

 Score =  313 bits (801), Expect = 6e-85
 Identities = 212/652 (32%), Positives = 306/652 (46%), Gaps = 47/652 (7%)

Query: 77  GDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTC 136
           G S IL+++ N +L+         +  G  V  +G   E+C YQG +RG   S+V++ TC
Sbjct: 97  GTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNPDSFVALSTC 154

Query: 137 SGLRGLV-------VLTPERSYTLEQGPGDLQGPPII-SRIQDLHL---PGHTCALSWRE 185
            GL G+        ++ PE + T ++   D     +  SR+ +  L   P     ++   
Sbjct: 155 HGLHGMFYDGNHTYLIEPEENDTTQE---DFHFHSVYKSRLFEFSLDDLPSEFQQVNITP 211

Query: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVAL 244
           S    KP      ++  R  R+V  ETK +EL+IV DH   +K+R    H       V  
Sbjct: 212 SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVN 271

Query: 245 LLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQL 303
           + D  ++  L  R+ LV +E W   +   IS NP +TL  F+ +RR  +  +   D+  L
Sbjct: 272 MADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK--SDAVHL 329

Query: 304 VTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHD---L 360
            +G+ F     G A    ICS    GGVN    T ++ V  ++A  L H++G+  D   L
Sbjct: 330 FSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAHNIGIISDKRKL 387

Query: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL--P 418
               C C        CIM  +  +LP   F+ C+       L  G G+CLF +   L  P
Sbjct: 388 ASGECKCEDTWSG--CIMGDTGYYLPK-KFTQCNIEEYHDFLNSGGGACLFNKPSKLLDP 444

Query: 419 PMAAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLRPGAQCASDGPCCQNCQLRP 475
           P    CGN F+E GE+CDCG   +CV     CC    C L   +QC SDG CC+ C+ +P
Sbjct: 445 PE---CGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQC-SDGLCCKKCKFQP 498

Query: 476 SGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLW 535
            G  CR    DCD+ E C G+SSQC P++   DG  C G Q +C  GRC +  +QC+ +W
Sbjct: 499 MGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIW 558

Query: 536 GPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSI 595
           G     +   C +  N  G   G+CG++   +++ C  RD +CG L C      P LG +
Sbjct: 559 GQKVTASDKYCYEKLNIEGTEKGNCGKD-KDTWIQCNKRDVLCGYLLCTNIGNIPRLGEL 617

Query: 596 RDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654
              +  T+ V  G  LNCS  H+ L  DV    +   GT CGP ++C++HRC  V     
Sbjct: 618 DGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVE-DGTPCGPQMMCLEHRCLPVASFNF 676

Query: 655 QECRSK-----CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLS 701
             C S      C G+GVC +   C C   W   DC T         TG+ LS
Sbjct: 677 STCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728


>gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprotein
           [Homo sapiens]
          Length = 870

 Score =  313 bits (801), Expect = 6e-85
 Identities = 212/652 (32%), Positives = 306/652 (46%), Gaps = 47/652 (7%)

Query: 77  GDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTC 136
           G S IL+++ N +L+         +  G  V  +G   E+C YQG +RG   S+V++ TC
Sbjct: 97  GTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNPDSFVALSTC 154

Query: 137 SGLRGLV-------VLTPERSYTLEQGPGDLQGPPII-SRIQDLHL---PGHTCALSWRE 185
            GL G+        ++ PE + T ++   D     +  SR+ +  L   P     ++   
Sbjct: 155 HGLHGMFYDGNHTYLIEPEENDTTQE---DFHFHSVYKSRLFEFSLDDLPSEFQQVNITP 211

Query: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVAL 244
           S    KP      ++  R  R+V  ETK +EL+IV DH   +K+R    H       V  
Sbjct: 212 SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVN 271

Query: 245 LLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQL 303
           + D  ++  L  R+ LV +E W   +   IS NP +TL  F+ +RR  +  +   D+  L
Sbjct: 272 MADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK--SDAVHL 329

Query: 304 VTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHD---L 360
            +G+ F     G A    ICS    GGVN    T ++ V  ++A  L H++G+  D   L
Sbjct: 330 FSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAHNIGIISDKRKL 387

Query: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL--P 418
               C C        CIM  +  +LP   F+ C+       L  G G+CLF +   L  P
Sbjct: 388 ASGECKCEDTWSG--CIMGDTGYYLPK-KFTQCNIEEYHDFLNSGGGACLFNKPSKLLDP 444

Query: 419 PMAAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLRPGAQCASDGPCCQNCQLRP 475
           P    CGN F+E GE+CDCG   +CV     CC    C L   +QC SDG CC+ C+ +P
Sbjct: 445 PE---CGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQC-SDGLCCKKCKFQP 498

Query: 476 SGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLW 535
            G  CR    DCD+ E C G+SSQC P++   DG  C G Q +C  GRC +  +QC+ +W
Sbjct: 499 MGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIW 558

Query: 536 GPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSI 595
           G     +   C +  N  G   G+CG++   +++ C  RD +CG L C      P LG +
Sbjct: 559 GQKVTASDKYCYEKLNIEGTEKGNCGKD-KDTWIQCNKRDVLCGYLLCTNIGNIPRLGEL 617

Query: 596 RDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654
              +  T+ V  G  LNCS  H+ L  DV    +   GT CGP ++C++HRC  V     
Sbjct: 618 DGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVE-DGTPCGPQMMCLEHRCLPVASFNF 676

Query: 655 QECRSK-----CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLS 701
             C S      C G+GVC +   C C   W   DC T         TG+ LS
Sbjct: 677 STCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728


>gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprotein
           [Homo sapiens]
          Length = 859

 Score =  313 bits (801), Expect = 6e-85
 Identities = 212/652 (32%), Positives = 306/652 (46%), Gaps = 47/652 (7%)

Query: 77  GDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTC 136
           G S IL+++ N +L+         +  G  V  +G   E+C YQG +RG   S+V++ TC
Sbjct: 97  GTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNPDSFVALSTC 154

Query: 137 SGLRGLV-------VLTPERSYTLEQGPGDLQGPPII-SRIQDLHL---PGHTCALSWRE 185
            GL G+        ++ PE + T ++   D     +  SR+ +  L   P     ++   
Sbjct: 155 HGLHGMFYDGNHTYLIEPEENDTTQE---DFHFHSVYKSRLFEFSLDDLPSEFQQVNITP 211

Query: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVAL 244
           S    KP      ++  R  R+V  ETK +EL+IV DH   +K+R    H       V  
Sbjct: 212 SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVN 271

Query: 245 LLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQL 303
           + D  ++  L  R+ LV +E W   +   IS NP +TL  F+ +RR  +  +   D+  L
Sbjct: 272 MADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK--SDAVHL 329

Query: 304 VTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHD---L 360
            +G+ F     G A    ICS    GGVN    T ++ V  ++A  L H++G+  D   L
Sbjct: 330 FSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAHNIGIISDKRKL 387

Query: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL--P 418
               C C        CIM  +  +LP   F+ C+       L  G G+CLF +   L  P
Sbjct: 388 ASGECKCEDTWSG--CIMGDTGYYLPK-KFTQCNIEEYHDFLNSGGGACLFNKPSKLLDP 444

Query: 419 PMAAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLRPGAQCASDGPCCQNCQLRP 475
           P    CGN F+E GE+CDCG   +CV     CC    C L   +QC SDG CC+ C+ +P
Sbjct: 445 PE---CGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQC-SDGLCCKKCKFQP 498

Query: 476 SGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLW 535
            G  CR    DCD+ E C G+SSQC P++   DG  C G Q +C  GRC +  +QC+ +W
Sbjct: 499 MGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIW 558

Query: 536 GPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSI 595
           G     +   C +  N  G   G+CG++   +++ C  RD +CG L C      P LG +
Sbjct: 559 GQKVTASDKYCYEKLNIEGTEKGNCGKD-KDTWIQCNKRDVLCGYLLCTNIGNIPRLGEL 617

Query: 596 RDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654
              +  T+ V  G  LNCS  H+ L  DV    +   GT CGP ++C++HRC  V     
Sbjct: 618 DGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVE-DGTPCGPQMMCLEHRCLPVASFNF 676

Query: 655 QECRSK-----CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLS 701
             C S      C G+GVC +   C C   W   DC T         TG+ LS
Sbjct: 677 STCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728


>gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo
           sapiens]
          Length = 769

 Score =  312 bits (800), Expect = 7e-85
 Identities = 240/727 (33%), Positives = 331/727 (45%), Gaps = 64/727 (8%)

Query: 9   LGLLGAGSPLPSWPLPNIGGTEEQQA-ESEKAPREPLEPQVLQDDLPISLKKVLQTSLPE 67
           LG  G    L    LP +GG    +  E  +  RE    +V +  L   +++      P 
Sbjct: 22  LGTQGPAGALRWGGLPQLGGPGAPEVTEPSRLVRESSGGEVRKQQLDTRVRQEPPGGPPV 81

Query: 68  PLR---IKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVR 124
            L      +     +  L+L  N  L+  +     +  +GT   S G   ++C YQG++R
Sbjct: 82  HLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSREGTTQHSTGAG-DHCYYQGKLR 140

Query: 125 GYAGSWVSICTCSGLRGLVVLTPERSYTLEQ----GP-GDLQGP--------PIISRIQD 171
           G   S+ ++ TC GL G V      +Y +E     GP G  QGP        P++     
Sbjct: 141 GNPHSFAALSTCQGLHG-VFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLG 199

Query: 172 LHLPGHTCALSWRESVHTQKPPEHPL--GQRHIRRRRDVV-TETKTVELVIVADHSEAQK 228
              PG   A+  + +     PP  P    +R +RR    V +ETK VEL+++ DH   ++
Sbjct: 200 CREPGCLFAVPAQSA-----PPNRPRLRRKRQVRRGHPTVHSETKYVELIVINDHQLFEQ 254

Query: 229 YRDFQHLL-NRTLEVALLLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLH 286
            R    L  N    V  L D  ++  LN R+ LV +E W   D +++  +   TL   + 
Sbjct: 255 MRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMV 314

Query: 287 WRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSI 346
           +RR  L    P D+  L +G +F   + G A    ICS    GGVN   +   + V  ++
Sbjct: 315 YRREGLPE--PSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEYGNMGAMAV--TL 370

Query: 347 AHELGHSLGL---DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALL 403
           A  LG +LG+    H      C CP       CIME +  +LP   FS CS     + L 
Sbjct: 371 AQTLGQNLGMMWNKHRSSAGDCKCPDIWLG--CIMEDTGFYLPR-KFSRCSIDEYNQFLQ 427

Query: 404 DGMGSCLFERLPSL--PPMAAFCGNMFVEPGEQCDCGFLDDCVDP---CCDSLTCQLRPG 458
           +G GSCLF +   L  PP    CGN FVE GE+CDCG + +C      CC    C L   
Sbjct: 428 EGGGSCLFNKPLKLLDPPE---CGNGFVEAGEECDCGSVQECSRAGGNCCKK--CTLTHD 482

Query: 459 AQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAV 518
           A C SDG CC+ C+  P G  CR    +CD+ E C GDSSQCPP++   DG  C   Q  
Sbjct: 483 AMC-SDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGR 541

Query: 519 CMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAIC 578
           C  GRC +  +QCQ LWG  A  A   C +  N  G   GSCGR  SG +V C+ +D +C
Sbjct: 542 CYGGRCKTRDRQCQVLWGHAA--ADRFCYEKLNVEGTERGSCGRKGSG-WVQCSKQDVLC 598

Query: 579 GQLQCQTGRTQPLLGS-IRDLLWETIDVNGTELNCSWVHLDL--GSDVAQPLLTLPGTAC 635
           G L C      P LG  + D+   T    G EL+C   H+ L  GSD++       GTAC
Sbjct: 599 GFLLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGSDLS---YVEDGTAC 655

Query: 636 GPGLVCIDHRCQRVDLLGAQEC-----RSKCHGHGVCDSNRHCYCEEGWAPPDCTTQLKA 690
           GP ++C+DHRC          C     R  C  HGVC +   C C+  W   DC+     
Sbjct: 656 GPNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPL 715

Query: 691 TSSLTTG 697
            +S  TG
Sbjct: 716 PTSPPTG 722


>gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo
           sapiens]
          Length = 832

 Score =  295 bits (755), Expect = 1e-79
 Identities = 195/640 (30%), Positives = 300/640 (46%), Gaps = 50/640 (7%)

Query: 72  KLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWV 131
           ++E  G   IL+L+ N  L+      + Y+ +G    S+G   E+C Y G +RG   S V
Sbjct: 154 QIEAFGSKFILDLILNNGLLSSDYVEIHYE-NGKPQYSKGG--EHCYYHGSIRGVKDSKV 210

Query: 132 SICTCSGLRGLV-------VLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWR 184
           ++ TC+GL G+        ++ P      E+  G    P II +     L G        
Sbjct: 211 ALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGR---PHIIQKT----LAGQYS--KQM 261

Query: 185 ESVHTQKPPEHPL---------GQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQ-H 234
           +++  ++  + P           +R +   R +  E K +EL+IV DH   +K+R    H
Sbjct: 262 KNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAH 321

Query: 235 LLNRTLEVALLLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLL 293
             N    V  L+D+ ++  LN RV LV +E WT++D ++I+ NP   L  F  +R+    
Sbjct: 322 TNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQRI-- 379

Query: 294 PRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHS 353
            +   D+  L++  +F      ++    +CS   + GV ++     + VA  ++  L  +
Sbjct: 380 -KQHADAVHLISRVTFHYKRSSLSYFGGVCSR--TRGVGVNEYGLPMAVAQVLSQSLAQN 436

Query: 354 LGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER 413
           LG+  +       C        CIME  T       FS CS       L  G G+CLF R
Sbjct: 437 LGIQWEPSSRKPKCDCTESWGGCIME-ETGVSHSRKFSKCSILEYRDFLQRGGGACLFNR 495

Query: 414 LPSLPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQN--C 471
            P+       CGN +VE GE+CDCGF  +C   CC    C L  GA C SDGPCC N  C
Sbjct: 496 -PTKLFEPTECGNGYVEAGEECDCGFHVECYGLCCKK--CSLSNGAHC-SDGPCCNNTSC 551

Query: 472 QLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQC 531
             +P G++CR    +CD+ E+C GDS QCPP++   DG  C   Q  C +G C +   QC
Sbjct: 552 LFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQC 611

Query: 532 QSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPL 591
           Q +WG  A  +   C +  NT G   G+CG++    ++ C+  D  CG L C      P 
Sbjct: 612 QYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKD-GDRWIQCSKHDVFCGFLLCTNLTRAPR 670

Query: 592 LGSIR-DLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650
           +G ++ +++  +    G  ++CS  H+ L  D     +   GT CGP ++C+D +C ++ 
Sbjct: 671 IGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDTDVGYVE-DGTPCGPSMMCLDRKCLQIQ 729

Query: 651 LLGAQEC-----RSKCHGHGVCDSNRHCYCEEGWAPPDCT 685
            L    C        C GHGVC +   C C+  WA  DC+
Sbjct: 730 ALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCS 769


>gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo
           sapiens]
          Length = 790

 Score =  288 bits (737), Expect = 1e-77
 Identities = 197/626 (31%), Positives = 297/626 (47%), Gaps = 34/626 (5%)

Query: 68  PLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYA 127
           P+   L+L G  H+L L   R L+P    +  +   G  +    +  ++C Y G V+   
Sbjct: 61  PVSYLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESL 120

Query: 128 GSWVSICTC-SGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRES 186
            S  +I TC  GLRG+  +  +  Y +E          ++  ++        C LS  E 
Sbjct: 121 DSKATISTCMGGLRGVFNIDAKH-YQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEI 179

Query: 187 VHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALLL 246
                P E+   +  +R         K +EL+++ D S   +YR   + L++ +  A+LL
Sbjct: 180 EWQMAPYEN---KARLRDFPGSYKHPKYLELILLFDQS---RYRFVNNNLSQVIHDAILL 233

Query: 247 ----DTFFRPLNVRVALVGLEAWTQRDLVEIS-PNPAVTLENFLHWRRAHLLPRLPHDSA 301
               DT+F+ + +R+ L  LE WT  + + +  P  A  L  F+ ++++ L  RL  D A
Sbjct: 234 TGIMDTYFQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWA 293

Query: 302 QLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLP 361
            L     ++           +CS +++G V+    T+IL  A+  AHELGH++G+ HD  
Sbjct: 294 HLYLQRKYNDALAWSF--GKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHD-- 349

Query: 362 GNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMA 421
              C C G      CIM +         FSNCS  +  K +  G  +CL   +P L  + 
Sbjct: 350 EQYCQCRGRL---NCIMGSGRT-----GFSNCSYISFFKHISSG-ATCL-NNIPGLGYVL 399

Query: 422 AFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480
             CGN  VE  E+CDCG  ++C  D CC S  C+L+PGA C S G CC +C+ RPSG+ C
Sbjct: 400 KRCGNKIVEDNEECDCGSTEECQKDRCCQS-NCKLQPGANC-SIGLCCHDCRFRPSGYVC 457

Query: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540
           R    +CDL E+C G+SS CP DV   DG PC   +  C    C S   QCQS++GP A 
Sbjct: 458 RQEGNECDLAEYCDGNSSSCPNDVYKQDGTPCK-YEGRCFRKGCRSRYMQCQSIFGPDAM 516

Query: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600
            A   C    N  G+ FG+C      ++  C   ++ICG+LQC    T P L     ++ 
Sbjct: 517 EAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIIS 576

Query: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTL--PGTACGPGLVCIDHRCQRVDLLGAQECR 658
             +         +  HL +   +  P L +   GT+CG G VC    C    +L      
Sbjct: 577 THLQAENLMCWGTGYHLSM-KPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLP 635

Query: 659 SKCHGHGVCDSNRHCYCEEGWAPPDC 684
            KC+  GVC++ ++C+C  GWAPP C
Sbjct: 636 EKCNTRGVCNNRKNCHCMYGWAPPFC 661


>gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
           sapiens]
          Length = 776

 Score =  286 bits (732), Expect = 6e-77
 Identities = 201/632 (31%), Positives = 294/632 (46%), Gaps = 39/632 (6%)

Query: 66  PEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRG 125
           P  L   L   G  +I+ +  N+ L      +  Y      +  +    ++C Y G V G
Sbjct: 108 PGWLSYSLRFGGQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEG 167

Query: 126 YAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGP--PIISRIQ--DLHLPGHTCAL 181
              S V++ TCSG  G + +        E  P  +      ++ +I   D   P   C L
Sbjct: 168 VPESLVALSTCSG--GFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGL 225

Query: 182 SWRESVHTQKPPEHPLGQRHIRRRRDVV---TETKTVELVIVADHSEAQ-KYRDFQHLLN 237
           +  +  H     E  L      ++   V   T  + VELV+V D+        +   + +
Sbjct: 226 TEEKIAHQM---ELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQH 282

Query: 238 RTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297
               V  ++D+F+ PL V V L G++ WT  + +  S +    LE+F  W+  +L  RL 
Sbjct: 283 EVFNVVNIVDSFYHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQ 342

Query: 298 HDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLD 357
           HD A L    +  G  +G+A    IC   F+ GV++     ++  A ++ HELGH+LG+ 
Sbjct: 343 HDVAHLFIKDT-QGMKLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQ 401

Query: 358 HDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL 417
           HD     C C      + CIM A         FSNCS      + +   G C+  + P  
Sbjct: 402 HDTQW--CVCE----LQWCIMHAYRKVTT--KFSNCSYAQYWDSTISS-GLCI--QPPPY 450

Query: 418 PP---MAAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQL 473
           P       +CGN+ VE GE+CDCG +  C  DPCC  L C L PGA CA  G CC++C+ 
Sbjct: 451 PGNIFRLKYCGNLVVEEGEECDCGTIRQCAKDPCC-LLNCTLHPGAACAF-GICCKDCKF 508

Query: 474 RPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQS 533
            PSG  CR   G+CDLPE+C G S QCP DV + DG  C    A C    C ++  QC+ 
Sbjct: 509 LPSGTLCRQQVGECDLPEWCNGTSHQCPDDVYVQDGISC-NVNAFCYEKTCNNHDIQCKE 567

Query: 534 LWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLG 593
           ++G  A+ A+  C Q  NT+GN FG CG     +YV C   D +CG++QC+     P L 
Sbjct: 568 IFGQDARSASQSCYQEINTQGNRFGHCG-IVGTTYVKCWTPDIMCGRVQCENVGVIPNL- 625

Query: 594 SIRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLG 653
            I     +   +N T   C      LG  +        GT CGP  +CI  +C  +  L 
Sbjct: 626 -IEHSTVQQFHLNDT--TCWGTDYHLGMAIPDIGEVKDGTVCGPEKICIRKKCASMVHL- 681

Query: 654 AQECRSK-CHGHGVCDSNRHCYCEEGWAPPDC 684
           +Q C+ K C+  G+C++ +HC+C   WAPP C
Sbjct: 682 SQACQPKTCNMRGICNNKQHCHCNHEWAPPYC 713


>gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo
           sapiens]
          Length = 722

 Score =  285 bits (729), Expect = 1e-76
 Identities = 207/693 (29%), Positives = 320/693 (46%), Gaps = 45/693 (6%)

Query: 66  PEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRG 125
           P  L   L   G  H++ +   + LV     +  Y  +   +  +    ++C Y G V G
Sbjct: 58  PGWLSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEG 117

Query: 126 YAGSWVSICTC-SGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQ--DLHLPGHTCALS 182
              S V    C  G RG++ ++   +Y +E          ++ ++   +   P   C L+
Sbjct: 118 APESLVVFSACFGGFRGVLKISG-LTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLT 176

Query: 183 WRESVHTQKPPEHPLGQR-HIRRRRDVVTETKTVELVIVADHSE-AQKYRDFQHLLNRTL 240
            +E    Q   E         +   D  T    +ELV+V +H        +   +     
Sbjct: 177 EKEVARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVF 236

Query: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300
            V  ++D+ ++ L   + L+G+E W Q ++  ++    V L +F  W++  L  +L HD+
Sbjct: 237 LVVNIVDSMYQQLGTYIILIGIEIWNQGNVFPMTSIEQV-LNDFSQWKQISL-SQLQHDA 294

Query: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360
           A +    S     +G+A    IC P    GV+     +    A+++AHELGH+LG+ HD 
Sbjct: 295 AHMFIKNSLIS-ILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHD- 352

Query: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPP- 419
               C C      + CIM  +T  +P   F+NCS     K  L+  GSCL       PP 
Sbjct: 353 -EEFCFCG----ERGCIM--NTFRVPAEKFTNCSYADFMKTTLN-QGSCLHN-----PPR 399

Query: 420 -----MAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474
                M   CGN  VE  EQCDCG +  C    C  L C LRPGA CA  G CC++C+  
Sbjct: 400 LGEIFMLKRCGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAACAF-GLCCKDCKFM 458

Query: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534
           PSG  CR    +CDLPE+C G S QCP D  + DG PC+   A C   RC ++ Q C+ +
Sbjct: 459 PSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPCS-DSAYCYQKRCNNHDQHCREI 517

Query: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594
           +G  A+ A+  C +  N++GN FG CG N + +Y+ C   D  CG++QC+  R  PLL  
Sbjct: 518 FGKDAKSASQNCYKEINSQGNRFGHCGINGT-TYLKCHISDVFCGRVQCENVRDIPLLQD 576

Query: 595 IRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654
              L  +   +NG  + C  +   L  +++       GT CGPG +CI  +C  + +L  
Sbjct: 577 HFTL--QHTHING--VTCWGIDYHLRMNISDIGEVKDGTVCGPGKICIHKKCVSLSVLSH 632

Query: 655 QECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ------LKATSSLTTGLLLSLLVLLVL 708
                 C+  G+C++  HC+C  GW+PP C  +          +S   G+ L L+V+  L
Sbjct: 633 VCLPETCNMKGICNNKHHCHCGYGWSPPYCQHRGYGGSIDSGPASAKRGVFLPLIVIPSL 692

Query: 709 VMLGASYWYRARLHQRLCQLKGPTCQYRAAQSG 741
            +L  ++ +   L   L Q  GP  + +A  SG
Sbjct: 693 SVL--TFLFTVGLLMYLRQCSGPK-ETKAHSSG 722


>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  273 bits (699), Expect = 4e-73
 Identities = 220/815 (26%), Positives = 350/815 (42%), Gaps = 88/815 (10%)

Query: 73  LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132
           L   G  HI+ +   + L      +  Y   G  +  +     NC Y G V G   S VS
Sbjct: 56  LPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVS 115

Query: 133 ICTCSG--------------LRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHT 178
           + TC G              ++ L   T       +    + Q   + S      +   T
Sbjct: 116 LSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---T 172

Query: 179 CALSWRESVH-TQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLL 236
           C + + E  + TQK   +     H R           VE+V+V D+    +Y R+   LL
Sbjct: 173 CRMEFEEIDNSTQKQSSYVGWWIHFR----------IVEIVVVIDNYLYIRYERNDSKLL 222

Query: 237 NRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRL 296
                +  ++D+    + V+V L GLE WT ++L+ +  +   ++  +  W+  ++ PR+
Sbjct: 223 EDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRM 281

Query: 297 PHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGL 356
            HD++ L T     G + G+     +C+P  S  +    + ++   + ++AH LGH+LG+
Sbjct: 282 QHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM 340

Query: 357 DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPS 416
           +HD   ++C C  P     CIM       P   FSNCS     +  ++    CL E + +
Sbjct: 341 NHD--EDTCRCSQPR----CIMHEGNP--PITKFSNCSYGDFWEYTVERT-KCLLETVHT 391

Query: 417 LPPM-AAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474
                   CGN  VE GE+CDCG L  C  DPCC S  C L  G+ CA  G CC++C+  
Sbjct: 392 KDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAF-GLCCKDCKFL 449

Query: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534
           PSG  CR    +CDLPE+C G S +CP D  + DG PC   +  C    C    +QC+ +
Sbjct: 450 PSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRI 508

Query: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594
           +G GA  A+  C +  NT G+  G CG   + +Y+ C   D  CG++QC+     P +  
Sbjct: 509 FGAGANTASETCYKELNTLGDRVGHCGIK-NATYIKCNISDVQCGRIQCENVTEIPNMSD 567

Query: 595 IRDLLWETIDVNGTELNCSW---VHLDL-GSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650
              + W   +    ++ C W    HL + G D+ +      GT CG   +CI   C  + 
Sbjct: 568 HTTVHWARFN----DIMC-WSTDYHLGMKGPDIGE---VKDGTECGIDHICIHRHCVHIT 619

Query: 651 LLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ-----------LKATSSLTTGLL 699
           +L +    + C+  G+C++  HC+C   W PP+C  +            K         L
Sbjct: 620 ILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYL 679

Query: 700 LSLLVLLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK 759
             LL++++ ++L   Y        RLC+   P  + +  Q+  ++     QR    R  +
Sbjct: 680 CILLLIVLFILLCCLY--------RLCKKSKPIKKQQDVQTPSAKEEEKIQR----RPHE 727

Query: 760 ASALSFP-APPSRPLPPDPVSKRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPR 818
               S P   PS+  PP   S+     +  +  PP  P  + P V   +SQ      PP 
Sbjct: 728 LPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQ------PPV 781

Query: 819 KPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPP 853
            P  + PQ        P   +   P ++PS+  PP
Sbjct: 782 MPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPP 816


>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  273 bits (699), Expect = 4e-73
 Identities = 220/815 (26%), Positives = 350/815 (42%), Gaps = 88/815 (10%)

Query: 73  LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132
           L   G  HI+ +   + L      +  Y   G  +  +     NC Y G V G   S VS
Sbjct: 56  LPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVS 115

Query: 133 ICTCSG--------------LRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHT 178
           + TC G              ++ L   T       +    + Q   + S      +   T
Sbjct: 116 LSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---T 172

Query: 179 CALSWRESVH-TQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLL 236
           C + + E  + TQK   +     H R           VE+V+V D+    +Y R+   LL
Sbjct: 173 CRMEFEEIDNSTQKQSSYVGWWIHFR----------IVEIVVVIDNYLYIRYERNDSKLL 222

Query: 237 NRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRL 296
                +  ++D+    + V+V L GLE WT ++L+ +  +   ++  +  W+  ++ PR+
Sbjct: 223 EDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRM 281

Query: 297 PHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGL 356
            HD++ L T     G + G+     +C+P  S  +    + ++   + ++AH LGH+LG+
Sbjct: 282 QHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM 340

Query: 357 DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPS 416
           +HD   ++C C  P     CIM       P   FSNCS     +  ++    CL E + +
Sbjct: 341 NHD--EDTCRCSQPR----CIMHEGNP--PITKFSNCSYGDFWEYTVERT-KCLLETVHT 391

Query: 417 LPPM-AAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474
                   CGN  VE GE+CDCG L  C  DPCC S  C L  G+ CA  G CC++C+  
Sbjct: 392 KDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAF-GLCCKDCKFL 449

Query: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534
           PSG  CR    +CDLPE+C G S +CP D  + DG PC   +  C    C    +QC+ +
Sbjct: 450 PSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRI 508

Query: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594
           +G GA  A+  C +  NT G+  G CG   + +Y+ C   D  CG++QC+     P +  
Sbjct: 509 FGAGANTASETCYKELNTLGDRVGHCGIK-NATYIKCNISDVQCGRIQCENVTEIPNMSD 567

Query: 595 IRDLLWETIDVNGTELNCSW---VHLDL-GSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650
              + W   +    ++ C W    HL + G D+ +      GT CG   +CI   C  + 
Sbjct: 568 HTTVHWARFN----DIMC-WSTDYHLGMKGPDIGE---VKDGTECGIDHICIHRHCVHIT 619

Query: 651 LLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ-----------LKATSSLTTGLL 699
           +L +    + C+  G+C++  HC+C   W PP+C  +            K         L
Sbjct: 620 ILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYL 679

Query: 700 LSLLVLLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK 759
             LL++++ ++L   Y        RLC+   P  + +  Q+  ++     QR    R  +
Sbjct: 680 CILLLIVLFILLCCLY--------RLCKKSKPIKKQQDVQTPSAKEEEKIQR----RPHE 727

Query: 760 ASALSFP-APPSRPLPPDPVSKRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPR 818
               S P   PS+  PP   S+     +  +  PP  P  + P V   +SQ      PP 
Sbjct: 728 LPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQ------PPV 781

Query: 819 KPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPP 853
            P  + PQ        P   +   P ++PS+  PP
Sbjct: 782 MPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPP 816


>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  273 bits (699), Expect = 4e-73
 Identities = 220/815 (26%), Positives = 350/815 (42%), Gaps = 88/815 (10%)

Query: 73  LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132
           L   G  HI+ +   + L      +  Y   G  +  +     NC Y G V G   S VS
Sbjct: 56  LPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVS 115

Query: 133 ICTCSG--------------LRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHT 178
           + TC G              ++ L   T       +    + Q   + S      +   T
Sbjct: 116 LSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---T 172

Query: 179 CALSWRESVH-TQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLL 236
           C + + E  + TQK   +     H R           VE+V+V D+    +Y R+   LL
Sbjct: 173 CRMEFEEIDNSTQKQSSYVGWWIHFR----------IVEIVVVIDNYLYIRYERNDSKLL 222

Query: 237 NRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRL 296
                +  ++D+    + V+V L GLE WT ++L+ +  +   ++  +  W+  ++ PR+
Sbjct: 223 EDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRM 281

Query: 297 PHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGL 356
            HD++ L T     G + G+     +C+P  S  +    + ++   + ++AH LGH+LG+
Sbjct: 282 QHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM 340

Query: 357 DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPS 416
           +HD   ++C C  P     CIM       P   FSNCS     +  ++    CL E + +
Sbjct: 341 NHD--EDTCRCSQPR----CIMHEGNP--PITKFSNCSYGDFWEYTVERT-KCLLETVHT 391

Query: 417 LPPM-AAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474
                   CGN  VE GE+CDCG L  C  DPCC S  C L  G+ CA  G CC++C+  
Sbjct: 392 KDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAF-GLCCKDCKFL 449

Query: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534
           PSG  CR    +CDLPE+C G S +CP D  + DG PC   +  C    C    +QC+ +
Sbjct: 450 PSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRI 508

Query: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594
           +G GA  A+  C +  NT G+  G CG   + +Y+ C   D  CG++QC+     P +  
Sbjct: 509 FGAGANTASETCYKELNTLGDRVGHCGIK-NATYIKCNISDVQCGRIQCENVTEIPNMSD 567

Query: 595 IRDLLWETIDVNGTELNCSW---VHLDL-GSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650
              + W   +    ++ C W    HL + G D+ +      GT CG   +CI   C  + 
Sbjct: 568 HTTVHWARFN----DIMC-WSTDYHLGMKGPDIGE---VKDGTECGIDHICIHRHCVHIT 619

Query: 651 LLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ-----------LKATSSLTTGLL 699
           +L +    + C+  G+C++  HC+C   W PP+C  +            K         L
Sbjct: 620 ILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYL 679

Query: 700 LSLLVLLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK 759
             LL++++ ++L   Y        RLC+   P  + +  Q+  ++     QR    R  +
Sbjct: 680 CILLLIVLFILLCCLY--------RLCKKSKPIKKQQDVQTPSAKEEEKIQR----RPHE 727

Query: 760 ASALSFP-APPSRPLPPDPVSKRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPR 818
               S P   PS+  PP   S+     +  +  PP  P  + P V   +SQ      PP 
Sbjct: 728 LPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQ------PPV 781

Query: 819 KPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPP 853
            P  + PQ        P   +   P ++PS+  PP
Sbjct: 782 MPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPP 816


>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  273 bits (699), Expect = 4e-73
 Identities = 220/815 (26%), Positives = 350/815 (42%), Gaps = 88/815 (10%)

Query: 73  LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132
           L   G  HI+ +   + L      +  Y   G  +  +     NC Y G V G   S VS
Sbjct: 56  LPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVS 115

Query: 133 ICTCSG--------------LRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHT 178
           + TC G              ++ L   T       +    + Q   + S      +   T
Sbjct: 116 LSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---T 172

Query: 179 CALSWRESVH-TQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLL 236
           C + + E  + TQK   +     H R           VE+V+V D+    +Y R+   LL
Sbjct: 173 CRMEFEEIDNSTQKQSSYVGWWIHFR----------IVEIVVVIDNYLYIRYERNDSKLL 222

Query: 237 NRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRL 296
                +  ++D+    + V+V L GLE WT ++L+ +  +   ++  +  W+  ++ PR+
Sbjct: 223 EDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRM 281

Query: 297 PHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGL 356
            HD++ L T     G + G+     +C+P  S  +    + ++   + ++AH LGH+LG+
Sbjct: 282 QHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM 340

Query: 357 DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPS 416
           +HD   ++C C  P     CIM       P   FSNCS     +  ++    CL E + +
Sbjct: 341 NHD--EDTCRCSQPR----CIMHEGNP--PITKFSNCSYGDFWEYTVERT-KCLLETVHT 391

Query: 417 LPPM-AAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474
                   CGN  VE GE+CDCG L  C  DPCC S  C L  G+ CA  G CC++C+  
Sbjct: 392 KDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAF-GLCCKDCKFL 449

Query: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534
           PSG  CR    +CDLPE+C G S +CP D  + DG PC   +  C    C    +QC+ +
Sbjct: 450 PSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRI 508

Query: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594
           +G GA  A+  C +  NT G+  G CG   + +Y+ C   D  CG++QC+     P +  
Sbjct: 509 FGAGANTASETCYKELNTLGDRVGHCGIK-NATYIKCNISDVQCGRIQCENVTEIPNMSD 567

Query: 595 IRDLLWETIDVNGTELNCSW---VHLDL-GSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650
              + W   +    ++ C W    HL + G D+ +      GT CG   +CI   C  + 
Sbjct: 568 HTTVHWARFN----DIMC-WSTDYHLGMKGPDIGE---VKDGTECGIDHICIHRHCVHIT 619

Query: 651 LLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ-----------LKATSSLTTGLL 699
           +L +    + C+  G+C++  HC+C   W PP+C  +            K         L
Sbjct: 620 ILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYL 679

Query: 700 LSLLVLLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK 759
             LL++++ ++L   Y        RLC+   P  + +  Q+  ++     QR    R  +
Sbjct: 680 CILLLIVLFILLCCLY--------RLCKKSKPIKKQQDVQTPSAKEEEKIQR----RPHE 727

Query: 760 ASALSFP-APPSRPLPPDPVSKRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPR 818
               S P   PS+  PP   S+     +  +  PP  P  + P V   +SQ      PP 
Sbjct: 728 LPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQ------PPV 781

Query: 819 KPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPP 853
            P  + PQ        P   +   P ++PS+  PP
Sbjct: 782 MPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPP 816


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.138    0.452 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,946,923
Number of Sequences: 37866
Number of extensions: 2891244
Number of successful extensions: 28561
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 326
Number of HSP's successfully gapped in prelim test: 1416
Number of HSP's that attempted gapping in prelim test: 14721
Number of HSP's gapped (non-prelim): 8802
length of query: 862
length of database: 18,247,518
effective HSP length: 111
effective length of query: 751
effective length of database: 14,044,392
effective search space: 10547338392
effective search space used: 10547338392
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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