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Search of human proteins with 131889447
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|131889447 cancer susceptibility candidate 1 isoform c [Homo
sapiens]
(690 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|131889447 cancer susceptibility candidate 1 isoform c [Homo s... 1376 0.0
gi|131888105 cancer susceptibility candidate 1 isoform a [Homo s... 1253 0.0
gi|131889097 cancer susceptibility candidate 1 isoform b [Homo s... 1241 0.0
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 57 6e-08
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 55 3e-07
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 54 4e-07
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 53 8e-07
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 51 3e-06
gi|190341068 forkhead-associated (FHA) phosphopeptide binding do... 51 4e-06
gi|154354979 myosin X [Homo sapiens] 49 2e-05
gi|120431738 huntingtin-associated protein 1 isoform 2 [Homo sap... 49 2e-05
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 49 2e-05
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 49 2e-05
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 48 3e-05
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 48 3e-05
gi|116174778 centrosome spindle pole associated protein 1 isofor... 48 3e-05
gi|116174789 centrosome spindle pole associated protein 1 isofor... 48 3e-05
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 48 3e-05
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi... 48 3e-05
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 48 3e-05
gi|56549694 enabled homolog isoform a [Homo sapiens] 47 5e-05
gi|39930375 enabled homolog isoform b [Homo sapiens] 47 5e-05
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 47 5e-05
gi|38044112 restin isoform b [Homo sapiens] 47 6e-05
gi|4506751 restin isoform a [Homo sapiens] 47 6e-05
gi|221219020 NYD-SP11 protein [Homo sapiens] 46 1e-04
gi|205277396 dynactin 1 isoform 4 [Homo sapiens] 46 1e-04
gi|205277392 dynactin 1 isoform 3 [Homo sapiens] 46 1e-04
gi|13259508 dynactin 1 isoform 2 [Homo sapiens] 46 1e-04
gi|13259510 dynactin 1 isoform 1 [Homo sapiens] 46 1e-04
>gi|131889447 cancer susceptibility candidate 1 isoform c [Homo
sapiens]
Length = 690
Score = 1376 bits (3561), Expect = 0.0
Identities = 690/690 (100%), Positives = 690/690 (100%)
Query: 1 MRQTGGGATTDSASPVLNNVIKSQSYFTAKRVGLGNNSYLGVGRPSSQQWLSLPGPGGQG 60
MRQTGGGATTDSASPVLNNVIKSQSYFTAKRVGLGNNSYLGVGRPSSQQWLSLPGPGGQG
Sbjct: 1 MRQTGGGATTDSASPVLNNVIKSQSYFTAKRVGLGNNSYLGVGRPSSQQWLSLPGPGGQG 60
Query: 61 PKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHR 120
PKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHR
Sbjct: 61 PKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHR 120
Query: 121 LEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTF 180
LEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTF
Sbjct: 121 LEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTF 180
Query: 181 ISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELL 240
ISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELL
Sbjct: 181 ISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELL 240
Query: 241 HLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIG 300
HLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIG
Sbjct: 241 HLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIG 300
Query: 301 FEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEV 360
FEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEV
Sbjct: 301 FEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEV 360
Query: 361 EEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVSAAQL 420
EEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVSAAQL
Sbjct: 361 EEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVSAAQL 420
Query: 421 LLVENSSEKPDFFEDNVVDLCQFTTLGGVYHLDILELPPQCKPVKGWMIVEILKEGLQKY 480
LLVENSSEKPDFFEDNVVDLCQFTTLGGVYHLDILELPPQCKPVKGWMIVEILKEGLQKY
Sbjct: 421 LLVENSSEKPDFFEDNVVDLCQFTTLGGVYHLDILELPPQCKPVKGWMIVEILKEGLQKY 480
Query: 481 TYPPETTEEFETENAFPPIEVTLEVHENVIFFEDPVVVRWDAEGKHWRTDGISNVSYKPK 540
TYPPETTEEFETENAFPPIEVTLEVHENVIFFEDPVVVRWDAEGKHWRTDGISNVSYKPK
Sbjct: 481 TYPPETTEEFETENAFPPIEVTLEVHENVIFFEDPVVVRWDAEGKHWRTDGISNVSYKPK 540
Query: 541 ERLVTFSLDTFGPVTLIQDAHINMPYQSWELRPLDVNKVLLTVTTVFTEIQIQIKENLCM 600
ERLVTFSLDTFGPVTLIQDAHINMPYQSWELRPLDVNKVLLTVTTVFTEIQIQIKENLCM
Sbjct: 541 ERLVTFSLDTFGPVTLIQDAHINMPYQSWELRPLDVNKVLLTVTTVFTEIQIQIKENLCM 600
Query: 601 LSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKAY 660
LSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKAY
Sbjct: 601 LSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKAY 660
Query: 661 RQMALLSSAFAFGWSKWNLLCNSTKVVFKW 690
RQMALLSSAFAFGWSKWNLLCNSTKVVFKW
Sbjct: 661 RQMALLSSAFAFGWSKWNLLCNSTKVVFKW 690
>gi|131888105 cancer susceptibility candidate 1 isoform a [Homo
sapiens]
Length = 722
Score = 1253 bits (3242), Expect = 0.0
Identities = 630/630 (100%), Positives = 630/630 (100%)
Query: 60 GPKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWH 119
GPKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWH
Sbjct: 2 GPKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWH 61
Query: 120 RLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNT 179
RLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNT
Sbjct: 62 RLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNT 121
Query: 180 FISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQEL 239
FISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQEL
Sbjct: 122 FISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQEL 181
Query: 240 LHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQI 299
LHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQI
Sbjct: 182 LHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQI 241
Query: 300 GFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKE 359
GFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKE
Sbjct: 242 GFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKE 301
Query: 360 VEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVSAAQ 419
VEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVSAAQ
Sbjct: 302 VEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVSAAQ 361
Query: 420 LLLVENSSEKPDFFEDNVVDLCQFTTLGGVYHLDILELPPQCKPVKGWMIVEILKEGLQK 479
LLLVENSSEKPDFFEDNVVDLCQFTTLGGVYHLDILELPPQCKPVKGWMIVEILKEGLQK
Sbjct: 362 LLLVENSSEKPDFFEDNVVDLCQFTTLGGVYHLDILELPPQCKPVKGWMIVEILKEGLQK 421
Query: 480 YTYPPETTEEFETENAFPPIEVTLEVHENVIFFEDPVVVRWDAEGKHWRTDGISNVSYKP 539
YTYPPETTEEFETENAFPPIEVTLEVHENVIFFEDPVVVRWDAEGKHWRTDGISNVSYKP
Sbjct: 422 YTYPPETTEEFETENAFPPIEVTLEVHENVIFFEDPVVVRWDAEGKHWRTDGISNVSYKP 481
Query: 540 KERLVTFSLDTFGPVTLIQDAHINMPYQSWELRPLDVNKVLLTVTTVFTEIQIQIKENLC 599
KERLVTFSLDTFGPVTLIQDAHINMPYQSWELRPLDVNKVLLTVTTVFTEIQIQIKENLC
Sbjct: 482 KERLVTFSLDTFGPVTLIQDAHINMPYQSWELRPLDVNKVLLTVTTVFTEIQIQIKENLC 541
Query: 600 MLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKA 659
MLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKA
Sbjct: 542 MLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKA 601
Query: 660 YRQMALLSSAFAFGWSKWNLLCNSTKVVFK 689
YRQMALLSSAFAFGWSKWNLLCNSTKVVFK
Sbjct: 602 YRQMALLSSAFAFGWSKWNLLCNSTKVVFK 631
>gi|131889097 cancer susceptibility candidate 1 isoform b [Homo
sapiens]
Length = 716
Score = 1241 bits (3210), Expect = 0.0
Identities = 624/624 (100%), Positives = 624/624 (100%)
Query: 66 SGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKD 125
SGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKD
Sbjct: 2 SGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKD 61
Query: 126 LERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLWK 185
LERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLWK
Sbjct: 62 LERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLWK 121
Query: 186 EKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFG 245
EKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFG
Sbjct: 122 EKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFG 181
Query: 246 VATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPR 305
VATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPR
Sbjct: 182 VATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPR 241
Query: 306 ILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESK 365
ILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESK
Sbjct: 242 ILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESK 301
Query: 366 QQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVSAAQLLLVEN 425
QQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVSAAQLLLVEN
Sbjct: 302 QQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVSAAQLLLVEN 361
Query: 426 SSEKPDFFEDNVVDLCQFTTLGGVYHLDILELPPQCKPVKGWMIVEILKEGLQKYTYPPE 485
SSEKPDFFEDNVVDLCQFTTLGGVYHLDILELPPQCKPVKGWMIVEILKEGLQKYTYPPE
Sbjct: 362 SSEKPDFFEDNVVDLCQFTTLGGVYHLDILELPPQCKPVKGWMIVEILKEGLQKYTYPPE 421
Query: 486 TTEEFETENAFPPIEVTLEVHENVIFFEDPVVVRWDAEGKHWRTDGISNVSYKPKERLVT 545
TTEEFETENAFPPIEVTLEVHENVIFFEDPVVVRWDAEGKHWRTDGISNVSYKPKERLVT
Sbjct: 422 TTEEFETENAFPPIEVTLEVHENVIFFEDPVVVRWDAEGKHWRTDGISNVSYKPKERLVT 481
Query: 546 FSLDTFGPVTLIQDAHINMPYQSWELRPLDVNKVLLTVTTVFTEIQIQIKENLCMLSSIK 605
FSLDTFGPVTLIQDAHINMPYQSWELRPLDVNKVLLTVTTVFTEIQIQIKENLCMLSSIK
Sbjct: 482 FSLDTFGPVTLIQDAHINMPYQSWELRPLDVNKVLLTVTTVFTEIQIQIKENLCMLSSIK 541
Query: 606 LKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKAYRQMAL 665
LKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKAYRQMAL
Sbjct: 542 LKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKAYRQMAL 601
Query: 666 LSSAFAFGWSKWNLLCNSTKVVFK 689
LSSAFAFGWSKWNLLCNSTKVVFK
Sbjct: 602 LSSAFAFGWSKWNLLCNSTKVVFK 625
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 57.0 bits (136), Expect = 6e-08
Identities = 40/106 (37%), Positives = 58/106 (54%), Gaps = 6/106 (5%)
Query: 59 QGPKAKKSGSKKKKVTKA------ERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQR 112
+G K +K KKK +KA E L L+EEEER+ +EEEE + E+ E +R E +R
Sbjct: 322 KGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEER 381
Query: 113 IEKEKWHRLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQ 158
+E+EK R + K+ ER+ +E LL + EA + T L Q
Sbjct: 382 LEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQ 427
Score = 43.1 bits (100), Expect = 9e-04
Identities = 82/385 (21%), Positives = 155/385 (40%), Gaps = 49/385 (12%)
Query: 54 PGPGGQGPKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKY--EKEEMER-LEI 110
PGP + S K K ++ + ++E ER+ ++EE+A+L+ EKEE+E +
Sbjct: 208 PGPNIESGNEDDDASFKIKTVAQKKAE--KKERERKKRDEEKAKLRKLKEKEELETGKKD 265
Query: 111 QRIEKEKWHRLEAKDLERR----------NEELEELYLLERCFPEAEKLKQETKLLSQWK 160
Q +KE + E + ++ + +EE E E +K K++ K K
Sbjct: 266 QSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEK 325
Query: 161 HYIQCDGSPDPSVA--QEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPP 218
+ + PS A + M ++ KE+ E E+ K + L K K E
Sbjct: 326 EEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEE--ERLE 383
Query: 219 CDLQDKNIIQYQESILQLQELLHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLY 278
+ +++ + +E +L++ L E + +TL L + +E KD
Sbjct: 384 QEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLP--- 440
Query: 279 VWANLKKNPRHRSVRFSETQIGFEIPRILATSDI--AVRLLHTHYDHVSALHPVSTPSKE 336
KK P + + + E + + ++ AV ++ P P +E
Sbjct: 441 -----KKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEE 495
Query: 337 Y--------------TSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVE 382
+ TE V+ + ++E + E EEE +++E +E+E E
Sbjct: 496 EDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEE------EEDEESEE 549
Query: 383 EEQGDIEVKMSSAEEESEAIKCERE 407
EE+ + E + S +EE E + E++
Sbjct: 550 EEEEEGESEGSEGDEEDEKVSDEKD 574
Score = 41.2 bits (95), Expect = 0.003
Identities = 38/122 (31%), Positives = 61/122 (50%), Gaps = 12/122 (9%)
Query: 45 PSSQQWLSLPGPG---GQGPKAKKSGSKKK--KVTKAERLKLLQEEEERRLKEEEEARLK 99
P+S++ P +G K KK KKK K K + K + + +E A+LK
Sbjct: 293 PASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLK 352
Query: 100 YEKEEMERLE---IQRIEKEKWHRLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLL 156
E+E +R E I+R+E+ + R E + LE+ E ++ ER E+LK+E KLL
Sbjct: 353 EEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKER----KERLKKEGKLL 408
Query: 157 SQ 158
++
Sbjct: 409 TK 410
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 54.7 bits (130), Expect = 3e-07
Identities = 84/371 (22%), Positives = 160/371 (43%), Gaps = 45/371 (12%)
Query: 73 VTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRN-- 130
+T+ R LQ E E+ AR++ + + LE+Q +E ++ + K+LE
Sbjct: 1050 LTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQ 1109
Query: 131 ------------EELEELYL-LERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEM 177
ELEEL + L++ + +K QE +L+ + D M
Sbjct: 1110 KEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKK-----------DAQQTTLM 1158
Query: 178 NTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQ 237
N I+ ++ E +++ K+ + +L +++K ++ + + I Q S+ Q +
Sbjct: 1159 NMEIADYERLMKELNQKLTNKNNKIEDLEQEIK---IQKQKQETLQEEITSLQSSVQQYE 1215
Query: 238 ELLHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSET 297
E K ++L+K LAD + +I ++ + A+ ++ ++ T
Sbjct: 1216 E----KNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEIT 1271
Query: 298 QIGFEIPRILATS-DIAVRLLHTHYDHVSALHPVSTPSKEYTSAVT---ELVKDDVKNV- 352
+I L TS + R L + V+AL +K + VT E K V NV
Sbjct: 1272 SEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVL 1331
Query: 353 ----EKAISKEVEEESKQQ-ERGSHLIQEEEIKVEEEQGDIEVKMSSAE--EESEAIKCE 405
K++S+ E +KQ+ E LI + +IK+++ Q ++++ +S + + E
Sbjct: 1332 KQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLE 1391
Query: 406 REMKVLSETVS 416
R K+L ETVS
Sbjct: 1392 RHNKMLQETVS 1402
Score = 38.1 bits (87), Expect = 0.027
Identities = 98/447 (21%), Positives = 203/447 (45%), Gaps = 87/447 (19%)
Query: 66 SGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYE--KEEMERLEIQRIEK-------- 115
S S+K+K+T ++ L+E+ E +E++EA L YE +E ME L+ + E
Sbjct: 446 SDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEF 505
Query: 116 EKWHRLEAKDLERRNEELEELY-----LLE---RCFPEAEKLKQETKLLSQWKHYI---- 163
E + +A D+ ++L + LLE R E EKL + +L+ + ++ I
Sbjct: 506 ESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQ 565
Query: 164 ------------------QCDGSPDPSVAQEMNTFISLWKEKTNE--TFEEVIEK-SKVV 202
+ +G + S+ +E + FI+ K E F + E+ +++
Sbjct: 566 EKNGVYLLSLSQRDTMLKELEGKIN-SLTEEKDDFINKLKNSHEEMDNFHKKCEREERLI 624
Query: 203 LNLIEKLKFIL-----LETPPCDL----------QDKNIIQYQESILQLQELLHLKFGVA 247
L L +K++ + LE +L +D+N + ++ ++Q++ L K
Sbjct: 625 LELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDK---- 680
Query: 248 TEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPRIL 307
E+L + +L + ++ + K + L V+ + K++ ++ TQ+ ++ ++
Sbjct: 681 -EVLSAEVKSLYE-ENNKLSSEKKQLSRDLEVFLSQKEDV---ILKEHITQLEKKLQLMV 735
Query: 308 ATSDIAVRLLHTHYDHVSALHPVSTP----SKEYTSAVTELVKD-DVKNVEKAISKEVEE 362
D +LL + V L V T KE S V+E ++ DV NV +A+ + + +
Sbjct: 736 EEQDNLNKLLEN--EQVQKLF-VKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAK 792
Query: 363 ESKQQ-----ERGSHLIQ-EEEIKVEEEQGDI---EVKMSSAEEESEAIKCEREMKVLSE 413
++++ +R +++ E+EIK +E+ + E+K + E E + +E++ +
Sbjct: 793 INEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQS 852
Query: 414 TVSAAQ--LLLVENSSEKPDFFEDNVV 438
A Q LL ++N++EK N++
Sbjct: 853 EKEALQSDLLEMKNANEKTRLENQNLL 879
Score = 33.9 bits (76), Expect = 0.52
Identities = 73/409 (17%), Positives = 164/409 (40%), Gaps = 35/409 (8%)
Query: 65 KSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAK 124
K K K + L ++E EE+ E+E + K EK + ++++ ++ +K K
Sbjct: 929 KDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEK--INKIKLVAVKAKKELDSSRK 986
Query: 125 DLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVA--QEMNTFIS 182
+ + EELE L ++ +L + + IQ S + ++ + +
Sbjct: 987 ETQTVKEELESL------------RSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLD 1034
Query: 183 LWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHL 242
+ KE+ N FE IE +L +L+ L+ + +++++ E++ +LL +
Sbjct: 1035 VEKERAN-NFEHRIE------DLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEV 1087
Query: 243 KFGVATEILLKQASTLADLDSGNMEK--VIKDENVTLYVWANLKKNPRHRSVRFSETQIG 300
+ E+ +A +L++ ++K IK+ T+ L+ + + +T
Sbjct: 1088 QI---LEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQE 1144
Query: 301 FEIPRILATSDIAVRLLHTHYDH-VSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKE 359
E+ + A + + Y+ + L+ T + + +K K ++ + +E
Sbjct: 1145 LELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQ-KQKQETLQEE 1203
Query: 360 V---EEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVS 416
+ + +Q E + I++ +K ++E D K + + + E++ + V
Sbjct: 1204 ITSLQSSVQQYEEKNTKIKQLLVKTKKELAD--SKQAETDHLILQASLKGELEASQQQVE 1261
Query: 417 AAQLLLVENSSEKPDFFEDNVVDLCQFTTLGGVYHLDILELPPQCKPVK 465
++ L E +SEK E Q Y + L +C+ K
Sbjct: 1262 VYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAK 1310
Score = 33.1 bits (74), Expect = 0.88
Identities = 67/373 (17%), Positives = 163/373 (43%), Gaps = 44/373 (11%)
Query: 93 EEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEE---------LYLLERCF 143
E++A L+ + EE +++ E+ K+ ++++ EE+E+ LYL ++
Sbjct: 147 EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206
Query: 144 PEAEKLKQETKLLSQWKHYIQCDGSPDP----SVAQEMNTFISLWKEKTNETFEEVIEKS 199
++ K+ET ++Q ++ I+ + S+ +E+ ++ +E+ E ++ +
Sbjct: 207 ATTDE-KKET--VTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASA 263
Query: 200 K---VVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFGVATEILLKQAS 256
K +N + +LK L++ C+ +KNI + E EL +L+ + Q
Sbjct: 264 KEHEAEINKLNELKENLVKQ--CEASEKNIQKKYEC-----ELENLRKATSNANQDNQIC 316
Query: 257 TLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQI--GFEIPRILATSDIAV 314
++ ++ +E+V+ ++ ++ LK+ S+ E ++ + I
Sbjct: 317 SILLQENTFVEQVVNEK--VKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKD 374
Query: 315 RLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHLI 374
H D ++ + +KE V E +K ++ + K VE+ +++ +
Sbjct: 375 EFFHEREDLEFKINELLL-AKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQH 433
Query: 375 QEEEIKV--------EEEQGDIEVKMSSAEEESEAIKCEREMKVLS-----ETVSAAQLL 421
Q+E ++ E+E+ + ++ +E+ E ++ E++ +L+ E + Q
Sbjct: 434 QKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTE 493
Query: 422 LVENSSEKPDFFE 434
L E++ + FE
Sbjct: 494 LGESAGKISQEFE 506
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 54.3 bits (129), Expect = 4e-07
Identities = 75/345 (21%), Positives = 149/345 (43%), Gaps = 40/345 (11%)
Query: 70 KKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEE-MERLEIQRIEKEKWHRLEAKDLER 128
+++ K R + + E+E +++ +EE + +EKEE M R E EKE+ R + + +
Sbjct: 331 REQEEKMRRQEEMMWEKEEKMRRQEE--MMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWE 388
Query: 129 RNEELEEL----YLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLW 184
+ E++ EL + E+ + EK ++E K+ Q K QE +
Sbjct: 389 KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR-------------QEQEAKMWRQ 435
Query: 185 KEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKF 244
+EK E E++ E+ K + EK+ E ++K Q QE + + +E +H
Sbjct: 436 EEKIREQEEKIREQEKKMWRQEEKIH----EQEKIREEEKR--QEQEEMWRQEEKIH--- 486
Query: 245 GVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKK-NPRHRSVRFSETQIGFEI 303
E + +Q + + + EK+ K E VW +K + +R E ++ +
Sbjct: 487 --EQEEIWRQKEKMHEQE----EKIRKQEE---KVWRQEEKIREQEEKIREQEEKMWRQE 537
Query: 304 PRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEE 363
+I ++ H ++ E +++ + V + K E+E
Sbjct: 538 EKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQE 597
Query: 364 SKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREM 408
K+QE+ + ++EE K+ E++ I+ + E+ E I+ + EM
Sbjct: 598 EKRQEQEEKMWKQEE-KIREQEEKIQEQEEKIREQEEKIREQEEM 641
Score = 48.5 bits (114), Expect = 2e-05
Identities = 78/370 (21%), Positives = 156/370 (42%), Gaps = 53/370 (14%)
Query: 69 KKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRI-EKEKWHRLEAK--- 124
K++K+ + E + +EE+ R L+E+ + K ++E +R E ++I E+EK EAK
Sbjct: 375 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR 434
Query: 125 -------DLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEM 177
E+ E+ ++++ E E EK+++E K Q + + Q +++
Sbjct: 435 QEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQ---------EEKI 485
Query: 178 NTFISLW--KEKTNETFEEVIEKSKVVLNLIEKLK---FILLETPPCDLQDKNIIQYQES 232
+ +W KEK +E E++ ++ + V EK++ + E + + I+ QE
Sbjct: 486 HEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEE 545
Query: 233 ILQLQELLHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSV 292
+ + +E +H + + E ++ D EK+ + E VW +K
Sbjct: 546 MWREEEKMHEQEKIWEE---EKRQEQEDKMWRQEEKIREQEE---KVWRQEEKIREQEEK 599
Query: 293 RFSETQIGFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNV 352
R + + ++ + + + + +E E+ ++ + +
Sbjct: 600 RQEQEEKMWKQEEKIREQE----------EKIQEQEEKIREQEEKIREQEEMTQEQEEKM 649
Query: 353 EKAISKEVEEESKQQE------RGSHLIQEEEIKVEEEQGDI---EVKMSSAEE---ESE 400
+ K E+E K QE R I+E+E K+ E++ I E M EE E E
Sbjct: 650 GEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQE 709
Query: 401 AIKCEREMKV 410
CE+E K+
Sbjct: 710 EKMCEQEEKM 719
Score = 42.7 bits (99), Expect = 0.001
Identities = 47/184 (25%), Positives = 89/184 (48%), Gaps = 14/184 (7%)
Query: 64 KKSGSKKKKVTKAERLKLLQEE----EERRLKEEEEARLKYEKEEMERLEIQRIEKEKWH 119
+K +++K+ K E QEE +E +++E+EE + E++ E+ E+ R E+EK H
Sbjct: 496 EKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWR-EEEKMH 554
Query: 120 RLE-AKDLERRNEELEELYLLERCFPEAEK--LKQETKLLSQWKHYIQCDGS--PDPSVA 174
E + E+R E+ ++++ E E E+ +QE K+ Q + + +
Sbjct: 555 EQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKI 614
Query: 175 QEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESIL 234
+E I +EK E E++ E+ ++ EK+ E C+ ++K +Q QE +
Sbjct: 615 REQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMG--EQEEKMCEQEEK--MQEQEETM 670
Query: 235 QLQE 238
QE
Sbjct: 671 WRQE 674
Score = 33.1 bits (74), Expect = 0.88
Identities = 48/253 (18%), Positives = 111/253 (43%), Gaps = 29/253 (11%)
Query: 59 QGPKAKKSGSKKKKVTKAERLKLLQEEEERRLKE----------EEEARLKYEKEEMERL 108
Q K + +++ + E+ ++ ++EE+ +E E+E +++ ++E++ R
Sbjct: 456 QEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQ 515
Query: 109 EIQRIEKEKWHRLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGS 168
E + E+E+ R + + + R+ E++ E E + E EK+ ++ K+ + K Q D
Sbjct: 516 EEKIREQEEKIREQEEKMWRQEEKIRE---QEEMWREEEKMHEQEKIWEEEKRQEQEDKM 572
Query: 169 -PDPSVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNII 227
+E + +EK E E+ E+ + + EK++ Q++ I
Sbjct: 573 WRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIR----------EQEEKIQ 622
Query: 228 QYQESILQLQELLHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKK-N 286
+ +E I + +E K E+ +Q + + + E+ K + +W +K
Sbjct: 623 EQEEKIREQEE----KIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIR 678
Query: 287 PRHRSVRFSETQI 299
+ + +R E +I
Sbjct: 679 EQEKKIREQEEKI 691
Score = 33.1 bits (74), Expect = 0.88
Identities = 18/72 (25%), Positives = 45/72 (62%), Gaps = 4/72 (5%)
Query: 64 KKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEA 123
KK +++K+ + E +++QE+EE+ ++EE+ + EK + + +++R E++ W +
Sbjct: 682 KKIREQEEKIREQE--EMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWE--QE 737
Query: 124 KDLERRNEELEE 135
L ++ E+++E
Sbjct: 738 VRLRQQEEKMQE 749
Score = 32.3 bits (72), Expect = 1.5
Identities = 24/100 (24%), Positives = 53/100 (53%), Gaps = 8/100 (8%)
Query: 64 KKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEA 123
+K +++K+ + E + +E+E ++ E+EE + E++ E+ E ++EK E
Sbjct: 626 EKIREQEEKIREQEEMT---QEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEK 682
Query: 124 KDLERRNEELEELYLL----ERCFPEAEKL-KQETKLLSQ 158
K E+ + E+ ++ E+ + + EK+ +QE K+ Q
Sbjct: 683 KIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQ 722
Score = 30.8 bits (68), Expect = 4.4
Identities = 20/103 (19%), Positives = 58/103 (56%), Gaps = 7/103 (6%)
Query: 60 GPKAKKSGSKKKKVTKAERLKLLQEE----EERRLKEEEEARLKYEKEEMERLEIQRIEK 115
G + +K +++K+ + E QEE +E++++E+EE +++ ++E M+ E + E+
Sbjct: 650 GEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEE-KIREQEEMMQEQEEKMWEQ 708
Query: 116 EKWHRLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQ 158
E+ + + ++ + E++ E+ + + +L+Q+ + + +
Sbjct: 709 EEKMCEQEEKMQEQEEKMRRQE--EKMWEQEVRLRQQEEKMQE 749
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 53.1 bits (126), Expect = 8e-07
Identities = 80/369 (21%), Positives = 161/369 (43%), Gaps = 36/369 (9%)
Query: 57 GGQGPKAKKSGSKKKKVTKAERLKLLQEEE---ERRLKEEEEARLKYEKEEMERLEIQRI 113
G + +K ++K++ + E+ QE+E ++ L+E+EE + E++ E+ E R
Sbjct: 307 GKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMRE 366
Query: 114 EKEKWHRLEAKDLERRNEELEELYLL----ERCFPEAEKLKQ-ETKLLSQWKHYIQCDGS 168
++EK R E + E+ + E+ + ER + + E+L++ E ++ Q K + Q +
Sbjct: 367 QEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKM 426
Query: 169 PDPSVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQ 228
+ QE +EK E E + E+ K + E+ + + + Q++N+ +
Sbjct: 427 REEKKMQEQEKKTRDQEEKMQEE-ERIREREK---KMREEEETMREQEEKMQKQEENMWE 482
Query: 229 YQESILQLQELLHLKFGVATEILLKQASTLADLDS-GNMEKVIKDENVTLYVWANLKKNP 287
+E Q Q L K E L +Q + E+ I+D+ +W KK
Sbjct: 483 QEEKEWQQQRLPEQK-----EKLWEQEKMQEQEEKIWEQEEKIRDQE---EMWGQEKKMW 534
Query: 288 RHRSVRFSETQIGFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKD 347
R +R E Q+ + ++ +D + + ++ T E +++
Sbjct: 535 RQEKMREQEDQMWEQEEKMRDQE-------QKMWDQEERMEKKTQEQEKKTWDQEEKMRE 587
Query: 348 DVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDI---EVKMSSAEE---ESEA 401
+ + E+ K++ EE + +QE+E K++E++ + E KM EE E E
Sbjct: 588 EERMRER--EKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEE 645
Query: 402 IKCEREMKV 410
E+E K+
Sbjct: 646 KMWEQEEKM 654
Score = 39.7 bits (91), Expect = 0.009
Identities = 43/187 (22%), Positives = 87/187 (46%), Gaps = 27/187 (14%)
Query: 64 KKSGSKKKKVTKAERL-----KLLQEEE-----ERRLKEEEEARLKYEKEEMERLEIQRI 113
KK+ +++K+ + ER+ K+ +EEE E +++E+EE + E++ E+ E +
Sbjct: 576 KKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQE 635
Query: 114 EKEKWHRLEAKDLERRNEELEELYLLER--CFPEAEKLKQETKLLSQWKHYIQCDGSPDP 171
++EK E K E+ + E+ L E+ E EK++++ K+ Q + + +
Sbjct: 636 QEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKK 695
Query: 172 SVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQE 231
+ QE T W ++ E + E+ K + E ++ + + +Q QE
Sbjct: 696 TQEQEKKT----WDQEKMREEESMREREKKMREEEEMMR-----------EQEEKMQEQE 740
Query: 232 SILQLQE 238
+Q QE
Sbjct: 741 EKMQEQE 747
Score = 39.7 bits (91), Expect = 0.009
Identities = 28/104 (26%), Positives = 56/104 (53%), Gaps = 8/104 (7%)
Query: 64 KKSGSKKKKVTKAERLK---LLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHR 120
KK+ ++KK E+++ ++E E++ +EEE R + EK + + ++Q E+E W
Sbjct: 694 KKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMW-- 751
Query: 121 LEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQ 164
+ E+ E+ E+++ +R + EKL + K+ Q K + Q
Sbjct: 752 ---EQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQ 792
Score = 38.9 bits (89), Expect = 0.016
Identities = 29/147 (19%), Positives = 73/147 (49%), Gaps = 19/147 (12%)
Query: 64 KKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEA 123
+K +++K+ + E+++ +E+E++ ++E+ R E+E M E + E+E+ R +
Sbjct: 677 EKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMR---EEESMREREKKMREEEEMMREQE 733
Query: 124 KDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISL 183
+ ++ + E+++E E E +QE K+ Q + + P+ L
Sbjct: 734 EKMQEQEEKMQE--------QEEEMWEQEEKMWEQEEKMWEQQRLPEQKE--------KL 777
Query: 184 WKEKTNETFEEVIEKSKVVLNLIEKLK 210
W+ + + E++ E+ + + + EK++
Sbjct: 778 WEHEKMQEQEKIWEQEEKMRDQEEKMR 804
Score = 37.7 bits (86), Expect = 0.036
Identities = 24/99 (24%), Positives = 53/99 (53%), Gaps = 2/99 (2%)
Query: 62 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEK-WHR 120
K ++ S +++ K + + E+E +++E+EE + E+E E+ E ++EK W +
Sbjct: 708 KMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQ 767
Query: 121 LEAKDLERRNEELEELYLLERCFPEAEKLK-QETKLLSQ 158
+ + + E E++ E+ + + EK++ QE K+ Q
Sbjct: 768 QRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQ 806
Score = 35.4 bits (80), Expect = 0.18
Identities = 40/159 (25%), Positives = 69/159 (43%), Gaps = 16/159 (10%)
Query: 48 QQWLSLPGPGGQGPKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMER 107
Q W Q K + +K T+ + K +EE+ R EEE + EK+ E
Sbjct: 545 QMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMR---EEERMREREKKMREE 601
Query: 108 LEIQRIEKEKWHRLEAKDLERRNEELEELYLL----ERCFPEAEKL-KQETKLLSQWKHY 162
E+ R ++EK E K E+ + E+ + E+ + + EK+ +QE K+ Q +
Sbjct: 602 EEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLP 661
Query: 163 IQCDGSPDPSVAQEMNTFISLWKEKTNETFEEVIEKSKV 201
Q + + QE +EK E E++ E+ K+
Sbjct: 662 EQKEKLWEHEKMQE--------QEKMQEQEEKIWEQEKM 692
Score = 33.9 bits (76), Expect = 0.52
Identities = 33/146 (22%), Positives = 69/146 (47%), Gaps = 15/146 (10%)
Query: 77 ERLKLLQEEEERRLKEEEEARLKYEK----------EEMERLEIQRIEKEK---WHRLEA 123
E+ + +QE+EE+ ++EE+ + + EK +E + E QR+ ++K W +
Sbjct: 614 EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM 673
Query: 124 KDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISL 183
++ E+ E+ E+++ E+ E + +QE K Q K + +E +
Sbjct: 674 QEQEKMQEQEEKIWEQEKM--EKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMRE 731
Query: 184 WKEKTNETFEEVIEKSKVVLNLIEKL 209
+EK E E++ E+ + + EK+
Sbjct: 732 QEEKMQEQEEKMQEQEEEMWEQEEKM 757
Score = 30.0 bits (66), Expect = 7.5
Identities = 25/127 (19%), Positives = 64/127 (50%), Gaps = 18/127 (14%)
Query: 61 PKAKKSGSKKKKVTKAERL-----KLLQEEEERRLKEE----EEARLKYEKEEM------ 105
P+ K+ + +K+ + E++ K+ +EE+ R +EE +E +++ ++E+M
Sbjct: 771 PEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEK 830
Query: 106 ---ERLEIQRIEKEKWHRLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHY 162
+ ++ E++ W + E + + + +E + E+ + EK++++ + + +
Sbjct: 831 MWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEK 890
Query: 163 IQCDGSP 169
I C GSP
Sbjct: 891 IYCVGSP 897
Score = 29.6 bits (65), Expect = 9.8
Identities = 29/106 (27%), Positives = 44/106 (41%), Gaps = 22/106 (20%)
Query: 69 KKKKVTKAERLKLLQEEEERRLKEEEEARLKYEK--------------EEMERLEIQRIE 114
KKK E+L L + E+ +E + K E+ EEM R E + E
Sbjct: 224 KKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELRE 283
Query: 115 KEKWHRLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWK 160
+EK R + + + R+ E L E E + +QE K+ Q K
Sbjct: 284 QEKKIRKQEEKMWRQEERLRE--------QEGKMREQEEKMWRQEK 321
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 51.2 bits (121), Expect = 3e-06
Identities = 83/358 (23%), Positives = 144/358 (40%), Gaps = 44/358 (12%)
Query: 84 EEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEELYLLE--R 141
E E RL+ EE R+K E+++ E RIE E+ + A++ ERR E E E R
Sbjct: 266 EAERARLEAEERERIKAEQDKKIADERARIEAEE--KAAAQERERREAEERERMREEEKR 323
Query: 142 CFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLWKEKTNETFEEVIEKSKV 201
E +++K+E K ++ + I+ + Q + E+ E EK+KV
Sbjct: 324 AAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKV 383
Query: 202 V----LNLIEKLKFILLETP------PCDLQDK--NIIQYQESILQLQELLHLKFGVATE 249
+E+ K + ET ++ K N + QE LQ L T+
Sbjct: 384 EEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTK 443
Query: 250 ILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPRILAT 309
+ K+ D + E+ IKDE + K P+ F + + GF +
Sbjct: 444 VQAKREKLQEDKPTFKKEE-IKDEKI------KKDKEPKEEVKSFMDRKKGFTEVKSQNG 496
Query: 310 SDIAVRLLHTHYD--------HVSALHPVSTPSKEYTSAVTELVK----------DDVKN 351
+ +L HT V P E + EL + + +K
Sbjct: 497 EFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQ 556
Query: 352 VEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMK 409
++ + E+EE K++E +++EEE + ++E+ D +++ EEE +K E E +
Sbjct: 557 KQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLR---EEEEKRRLKEEIERR 611
Score = 50.8 bits (120), Expect = 4e-06
Identities = 84/362 (23%), Positives = 147/362 (40%), Gaps = 31/362 (8%)
Query: 64 KKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEA 123
+K + K+ +AER +L EE ER +K E++ ++ E+ +E E + ++ R EA
Sbjct: 255 EKMEEEDKERAEAERARLEAEERER-IKAEQDKKIADERARIEAEE--KAAAQERERREA 311
Query: 124 KDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISL 183
++ ER EE + R E +++K+E K ++ + I+ + Q +
Sbjct: 312 EERERMREEEK------RAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKR 365
Query: 184 WKEKTNETFEEVIEKSKVVLNL----IEKLKFILLETP------PCDLQDK--NIIQYQE 231
E+ E EK+KV +E+ K + ET ++ K N + QE
Sbjct: 366 AAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQE 425
Query: 232 SILQLQELLHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRS 291
LQ L T++ K+ D + E+ IKDE + K P+
Sbjct: 426 DKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEE-IKDEKI------KKDKEPKEEV 478
Query: 292 VRFSETQIGFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKN 351
F + + GF + + +L HT S +KE A + K
Sbjct: 479 KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQV---EAGKR 535
Query: 352 VEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVL 411
+E+ + E ES++ E+ QE +++EE + E + EEE + K E + L
Sbjct: 536 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKL 595
Query: 412 SE 413
E
Sbjct: 596 RE 597
Score = 40.0 bits (92), Expect = 0.007
Identities = 22/54 (40%), Positives = 33/54 (61%), Gaps = 2/54 (3%)
Query: 64 KKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEK 117
KK +++KV + E + QEE +R+L+EEEE R KEE+ER + EK +
Sbjct: 569 KKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRL--KEEIERRRAEAAEKRQ 620
Score = 36.2 bits (82), Expect = 0.10
Identities = 25/77 (32%), Positives = 41/77 (53%), Gaps = 3/77 (3%)
Query: 338 TSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAE- 396
T + E V +KN + IS E ++ +++E+GS I E EE++ E + + E
Sbjct: 217 TESQEETVVMSLKNGQ--ISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEA 274
Query: 397 EESEAIKCEREMKVLSE 413
EE E IK E++ K+ E
Sbjct: 275 EERERIKAEQDKKIADE 291
Score = 34.7 bits (78), Expect = 0.30
Identities = 29/86 (33%), Positives = 47/86 (54%), Gaps = 8/86 (9%)
Query: 72 KVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNE 131
K + ER K+L+EEE+R +++EEA K +EE +R + IE+ R EA + ++
Sbjct: 569 KKKREERRKVLEEEEQR--RKQEEADRKLREEEEKRRLKEEIER---RRAEAAEKRQKMP 623
Query: 132 E--LEELYLLERCF-PEAEKLKQETK 154
E L + +CF P+ LK E +
Sbjct: 624 EDGLSDDKKPFKCFTPKGSSLKIEER 649
Score = 33.5 bits (75), Expect = 0.68
Identities = 19/56 (33%), Positives = 33/56 (58%), Gaps = 1/56 (1%)
Query: 62 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEK 117
K + +++K +A+R KL +EEE+RRLKEE E R E+ +++ + +K
Sbjct: 577 KVLEEEEQRRKQEEADR-KLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDK 631
Score = 30.0 bits (66), Expect = 7.5
Identities = 21/78 (26%), Positives = 34/78 (43%)
Query: 343 ELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAI 402
E ++++ K + + EEE + E + +EE+ EE Q E + +AEE A
Sbjct: 315 ERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRAR 374
Query: 403 KCEREMKVLSETVSAAQL 420
E E + E QL
Sbjct: 375 AEEEEKAKVEEQKRNKQL 392
>gi|190341068 forkhead-associated (FHA) phosphopeptide binding domain
1 [Homo sapiens]
Length = 1412
Score = 50.8 bits (120), Expect = 4e-06
Identities = 84/394 (21%), Positives = 167/394 (42%), Gaps = 41/394 (10%)
Query: 64 KKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEME-------RLEIQRIEKE 116
+K K + R+K EEE+ R++E EE RL +KE +E R + +E E
Sbjct: 722 QKKALAKSITQEKNRVKEALEEEQTRVQELEE-RLARQKEVLESSIAHEKRKAKEALESE 780
Query: 117 KW-------HRLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSP 169
K H + K++ N E+ E E +K++ L++ K ++
Sbjct: 781 KRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQK 840
Query: 170 DPSVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQY 229
+ + +++ +++ +E E ++ + L L E L + + ++ +I
Sbjct: 841 EDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQ 900
Query: 230 QESILQLQ-ELLHLKFGVATEIL-----LKQ-ASTLADLDSGNMEKVIKDENVTLYVWAN 282
Q+ + LQ E + G EI+ +KQ A T+ L+ ++KV + A
Sbjct: 901 QKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEE-KLQKVTQHHKKIEGEIAT 959
Query: 283 LKKN-PRHRSVRFSETQIGFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAV 341
LK N P + R + P + ++ + + Y+H+ + + KE S
Sbjct: 960 LKDNDPAPKEERPQD-------PLVAPMTESSAK--DMAYEHL--IDDLLAAQKEILSQ- 1007
Query: 342 TELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEV-KMSSAEEESE 400
E++ K++ +A S+ + + E+ +++ + V+++ ++ V K A+ S
Sbjct: 1008 QEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSL 1067
Query: 401 AIKCEREMKVLSETVSAAQ----LLLVENSSEKP 430
K +RE+K L E + A+Q L L +KP
Sbjct: 1068 VEKKDRELKALEEALRASQEKHRLQLNTEKEQKP 1101
Score = 37.7 bits (86), Expect = 0.036
Identities = 100/416 (24%), Positives = 161/416 (38%), Gaps = 75/416 (18%)
Query: 70 KKKVTKAE-RLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLER 128
+K +T+A R+ L+ E + K E E + +++ + L + KEK ++ + +E+
Sbjct: 1015 RKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVL---KEKMAQMSSL-VEK 1070
Query: 129 RNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQ-CDGSP--DP------SVAQEMNT 179
++ EL+ L R E +L+ T+ + + Q CD S +P S +QE +
Sbjct: 1071 KDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQS 1130
Query: 180 FISLWKEKTNETFEEVIEKSKVVLN-LIEKLKFILLETPPCDLQDKNIIQYQESILQLQE 238
F L EEVI++ K L+ L ++K + P +N ES L L+
Sbjct: 1131 FSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQN-----ESFLDLKN 1185
Query: 239 ----------LLHLKFGVAT----EILLKQASTL------ADLDSGNM---------EKV 269
LL K + T EIL Q A SG M EK+
Sbjct: 1186 LRMENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKL 1245
Query: 270 IKDENVTLYVWANLKKNPRHRSVRFSETQ---------------IGFEIPRILATSDIAV 314
D + TL N+K H S+++ Q + +I ++
Sbjct: 1246 YLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKE 1305
Query: 315 RLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNV-EKAISKEVEEESKQQERGSHL 373
LL + V L + Y S V +L D K EKA+ KE E + Q L
Sbjct: 1306 ELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQ-----L 1360
Query: 374 IQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVSAAQLLLVENSSEK 429
QE+ I Q + + +S + + EREM + ++Q LL S K
Sbjct: 1361 CQEKRINRAIRQQKVGTRKASLKMDQ-----EREMLRKETSSKSSQSLLHSKPSGK 1411
Score = 33.1 bits (74), Expect = 0.88
Identities = 34/150 (22%), Positives = 73/150 (48%), Gaps = 14/150 (9%)
Query: 62 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRL 121
KAK++ K+KK + +L +++EE LKE++E L + + + + + + L
Sbjct: 808 KAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESL 867
Query: 122 EAKDLE-RRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTF 180
+A+ L + NE L EL + + + E +L+ Q K ++ E +
Sbjct: 868 KAESLALKLNETLAELET-----TKTKMIMVEERLILQQKMV--------KALQDEQESQ 914
Query: 181 ISLWKEKTNETFEEVIEKSKVVLNLIEKLK 210
++E+ E E++ + ++ +++L EKL+
Sbjct: 915 RHGFEEEIMEYKEQIKQHAQTIVSLEEKLQ 944
>gi|154354979 myosin X [Homo sapiens]
Length = 2058
Score = 48.9 bits (115), Expect = 2e-05
Identities = 28/97 (28%), Positives = 58/97 (59%), Gaps = 4/97 (4%)
Query: 63 AKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERL--EIQRIEKEKWHR 120
A+K ++KK + E K +EEE R +E EA L+ ++EE R E++ ++K +
Sbjct: 813 AEKREQEEKKKQEEEEKKKREEEERERERERREAELRAQQEEETRKQQELEALQKSQKEA 872
Query: 121 LEAKDLERR--NEELEELYLLERCFPEAEKLKQETKL 155
++LE++ N+++EE+ LE+ + +++K++ +L
Sbjct: 873 ELTRELEKQKENKQVEEILRLEKEIEDLQRMKEQQEL 909
Score = 33.1 bits (74), Expect = 0.88
Identities = 21/66 (31%), Positives = 39/66 (59%), Gaps = 4/66 (6%)
Query: 355 AISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSET 414
A +E EE+ KQ+E +EEE + E E+ + E++ A++E E K ++E++ L ++
Sbjct: 813 AEKREQEEKKKQEEEEKKKREEEERERERERREAELR---AQQEEETRK-QQELEALQKS 868
Query: 415 VSAAQL 420
A+L
Sbjct: 869 QKEAEL 874
Score = 29.6 bits (65), Expect = 9.8
Identities = 24/101 (23%), Positives = 45/101 (44%), Gaps = 17/101 (16%)
Query: 346 KDDVKNVEKAISKEVEEESKQQERGS-----HLIQEEEIKVEEEQGDIEVKMSSAE---- 396
+++ K E+ K+ EEE +++ER QEEE + ++E ++ AE
Sbjct: 818 QEEKKKQEEEEKKKREEEERERERERREAELRAQQEEETRKQQELEALQKSQKEAELTRE 877
Query: 397 --------EESEAIKCEREMKVLSETVSAAQLLLVENSSEK 429
+ E ++ E+E++ L +L L E S +K
Sbjct: 878 LEKQKENKQVEEILRLEKEIEDLQRMKEQQELSLTEASLQK 918
>gi|120431738 huntingtin-associated protein 1 isoform 2 [Homo
sapiens]
Length = 619
Score = 48.9 bits (115), Expect = 2e-05
Identities = 44/181 (24%), Positives = 85/181 (46%), Gaps = 17/181 (9%)
Query: 77 ERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEEL 136
E L+L + +E EEEE K +EE E E + + + H +A L +E
Sbjct: 251 ELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEE-DLQCAHPCDAPKLIS-----QEA 304
Query: 137 YLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLWKEKTNETFEEVI 196
L + P+ E L+++ +LL + H ++ + S ++ E I E+ +E +++
Sbjct: 305 LLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMA 364
Query: 197 EKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFGVATEILLKQAS 256
E S+V++ +E + Q + + + Q +L+LQ+ + +G TE L KQ +
Sbjct: 365 ELSEVLVLRLENY----------ERQQQEVARLQAQVLKLQQRCRM-YGAETEKLQKQLA 413
Query: 257 T 257
+
Sbjct: 414 S 414
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 48.5 bits (114), Expect = 2e-05
Identities = 45/153 (29%), Positives = 73/153 (47%), Gaps = 15/153 (9%)
Query: 62 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKY-EKEEMERLE---IQRIEKEK 117
KAK+ ++K K K ++E E RR +EEE RL++ ++EE ER +Q+ ++E+
Sbjct: 612 KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEE 671
Query: 118 WHRL----------EAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDG 167
RL E ++ ERR +E E E+ E E+ +QE +L Q + Q +
Sbjct: 672 QERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQ-ER 730
Query: 168 SPDPSVAQEMNTFISLWKEKTNETFEEVIEKSK 200
QE + L KE+ EE +K +
Sbjct: 731 LQAERELQEREKALRLQKEQLQRELEEKKKKEE 763
Score = 37.7 bits (86), Expect = 0.036
Identities = 31/113 (27%), Positives = 51/113 (45%), Gaps = 24/113 (21%)
Query: 62 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRI-------- 113
K ++ + +K +A+RL +E+E R + E+ R + E+ E ER E +R
Sbjct: 667 KKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRR 726
Query: 114 ------------EKEKWHRLEAKDLERRNEEL----EELYLLERCFPEAEKLK 150
E+EK RL+ + L+R EE E+ L ER E ++ K
Sbjct: 727 EQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKK 779
Score = 35.8 bits (81), Expect = 0.14
Identities = 30/120 (25%), Positives = 65/120 (54%), Gaps = 27/120 (22%)
Query: 62 KAKKSGSKKKKVTKAERLKLLQEEEERRLKE------------------EEEARLKYEKE 103
K K+ +K + ER++ ++EE+++++++ EE+A+ K +
Sbjct: 571 KLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAK 630
Query: 104 EMERLEIQRIEKEKWHR---LEAKDLERRNEELEELYLLERCFPEAEKLKQ--ETKLLSQ 158
+ME +E +R ++E+ R L+ ++ ERR++EL L ++ E E+L++ E K L++
Sbjct: 631 KMEEVEARRKQEEEARRLRWLQQEEEERRHQEL----LQKKKEEEQERLRKAAEAKRLAE 686
Score = 35.0 bits (79), Expect = 0.23
Identities = 24/65 (36%), Positives = 36/65 (55%), Gaps = 6/65 (9%)
Query: 92 EEEEARLKY--EKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEELYLLERCFPEAEKL 149
E+E RL+ KEE E+L Q++E++K RLE L+R + L ER E++
Sbjct: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARER----VEQM 591
Query: 150 KQETK 154
K+E K
Sbjct: 592 KEEKK 596
Score = 32.0 bits (71), Expect = 2.0
Identities = 28/81 (34%), Positives = 38/81 (46%), Gaps = 13/81 (16%)
Query: 342 TELVKDDVKNVEKAISK-------EVEEESKQQERGSHL--IQEEEIKVEEEQGDIEVKM 392
TE K++ EKA K EVE KQ+E L +Q+EE EE+ E+
Sbjct: 610 TEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE----EERRHQELLQ 665
Query: 393 SSAEEESEAIKCEREMKVLSE 413
EEE E ++ E K L+E
Sbjct: 666 KKKEEEQERLRKAAEAKRLAE 686
Score = 31.2 bits (69), Expect = 3.4
Identities = 26/103 (25%), Positives = 53/103 (51%), Gaps = 18/103 (17%)
Query: 70 KKKVTKAERLKLLQEEEE-RRLKEEEEARLKYEKEEMERLE-----------IQRIEKEK 117
+K+ + E L+ +E E+ RR K EE+ R + E+ +++R E ++++++EK
Sbjct: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595
Query: 118 WHRLEAK--DLERRNEELEELYLLERCFPEAEKLKQETKLLSQ 158
++E K ++ + E+ +E ER E K K K + +
Sbjct: 596 KKQIEQKFAQIDEKTEKAKE----ERLAEEKAKKKAAAKKMEE 634
Score = 30.8 bits (68), Expect = 4.4
Identities = 26/107 (24%), Positives = 60/107 (56%), Gaps = 11/107 (10%)
Query: 64 KKSGSKKKKVTKAERLKLLQEEEER--RLKEEEEARLKYE----KEEMERLEIQRIEKEK 117
K+ ++ K+ + ERL+ + + ER ++KEE++ +++ + E+ E+ + +R+ +EK
Sbjct: 563 KRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEK 622
Query: 118 WHRLEA----KDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWK 160
+ A +++E R ++ EE L R + E+ ++ +LL + K
Sbjct: 623 AKKKAAAKKMEEVEARRKQEEEARRL-RWLQQEEEERRHQELLQKKK 668
Score = 30.4 bits (67), Expect = 5.7
Identities = 20/78 (25%), Positives = 43/78 (55%), Gaps = 3/78 (3%)
Query: 354 KAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAE--EESEAIKCEREMKVL 411
K ++++ E+E ++QER +E+E + E+E+ + E +++ E E E ++ ERE++
Sbjct: 682 KRLAEQREQERREQERREQERREQE-RREQERREQERQLAEQERRREQERLQAERELQER 740
Query: 412 SETVSAAQLLLVENSSEK 429
+ + + L EK
Sbjct: 741 EKALRLQKEQLQRELEEK 758
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 48.5 bits (114), Expect = 2e-05
Identities = 45/153 (29%), Positives = 73/153 (47%), Gaps = 15/153 (9%)
Query: 62 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKY-EKEEMERLE---IQRIEKEK 117
KAK+ ++K K K ++E E RR +EEE RL++ ++EE ER +Q+ ++E+
Sbjct: 608 KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEE 667
Query: 118 WHRL----------EAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDG 167
RL E ++ ERR +E E E+ E E+ +QE +L Q + Q +
Sbjct: 668 QERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQ-ER 726
Query: 168 SPDPSVAQEMNTFISLWKEKTNETFEEVIEKSK 200
QE + L KE+ EE +K +
Sbjct: 727 LQAERELQEREKALRLQKEQLQRELEEKKKKEE 759
Score = 37.7 bits (86), Expect = 0.036
Identities = 31/113 (27%), Positives = 51/113 (45%), Gaps = 24/113 (21%)
Query: 62 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRI-------- 113
K ++ + +K +A+RL +E+E R + E+ R + E+ E ER E +R
Sbjct: 663 KKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRR 722
Query: 114 ------------EKEKWHRLEAKDLERRNEEL----EELYLLERCFPEAEKLK 150
E+EK RL+ + L+R EE E+ L ER E ++ K
Sbjct: 723 EQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKK 775
Score = 37.0 bits (84), Expect = 0.061
Identities = 25/66 (37%), Positives = 37/66 (56%), Gaps = 6/66 (9%)
Query: 91 KEEEEARLKY--EKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEELYLLERCFPEAEK 148
KE+E RL+ KEE E+L Q++E++K RLE L+R + L ER E+
Sbjct: 531 KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARER----VEQ 586
Query: 149 LKQETK 154
+K+E K
Sbjct: 587 MKEEKK 592
Score = 35.8 bits (81), Expect = 0.14
Identities = 30/120 (25%), Positives = 65/120 (54%), Gaps = 27/120 (22%)
Query: 62 KAKKSGSKKKKVTKAERLKLLQEEEERRLKE------------------EEEARLKYEKE 103
K K+ +K + ER++ ++EE+++++++ EE+A+ K +
Sbjct: 567 KLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAK 626
Query: 104 EMERLEIQRIEKEKWHR---LEAKDLERRNEELEELYLLERCFPEAEKLKQ--ETKLLSQ 158
+ME +E +R ++E+ R L+ ++ ERR++EL L ++ E E+L++ E K L++
Sbjct: 627 KMEEVEARRKQEEEARRLRWLQQEEEERRHQEL----LQKKKEEEQERLRKAAEAKRLAE 682
Score = 33.1 bits (74), Expect = 0.88
Identities = 27/104 (25%), Positives = 54/104 (51%), Gaps = 18/104 (17%)
Query: 69 KKKKVTKAERLKLLQEEEE-RRLKEEEEARLKYEKEEMERLE-----------IQRIEKE 116
K+K+ + E L+ +E E+ RR K EE+ R + E+ +++R E ++++++E
Sbjct: 531 KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 590
Query: 117 KWHRLEAK--DLERRNEELEELYLLERCFPEAEKLKQETKLLSQ 158
K ++E K ++ + E+ +E ER E K K K + +
Sbjct: 591 KKKQIEQKFAQIDEKTEKAKE----ERLAEEKAKKKAAAKKMEE 630
Score = 32.0 bits (71), Expect = 2.0
Identities = 28/81 (34%), Positives = 38/81 (46%), Gaps = 13/81 (16%)
Query: 342 TELVKDDVKNVEKAISK-------EVEEESKQQERGSHL--IQEEEIKVEEEQGDIEVKM 392
TE K++ EKA K EVE KQ+E L +Q+EE EE+ E+
Sbjct: 606 TEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE----EERRHQELLQ 661
Query: 393 SSAEEESEAIKCEREMKVLSE 413
EEE E ++ E K L+E
Sbjct: 662 KKKEEEQERLRKAAEAKRLAE 682
Score = 30.8 bits (68), Expect = 4.4
Identities = 26/107 (24%), Positives = 60/107 (56%), Gaps = 11/107 (10%)
Query: 64 KKSGSKKKKVTKAERLKLLQEEEER--RLKEEEEARLKYE----KEEMERLEIQRIEKEK 117
K+ ++ K+ + ERL+ + + ER ++KEE++ +++ + E+ E+ + +R+ +EK
Sbjct: 559 KRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEK 618
Query: 118 WHRLEA----KDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWK 160
+ A +++E R ++ EE L R + E+ ++ +LL + K
Sbjct: 619 AKKKAAAKKMEEVEARRKQEEEARRL-RWLQQEEEERRHQELLQKKK 664
Score = 30.4 bits (67), Expect = 5.7
Identities = 20/78 (25%), Positives = 43/78 (55%), Gaps = 3/78 (3%)
Query: 354 KAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAE--EESEAIKCEREMKVL 411
K ++++ E+E ++QER +E+E + E+E+ + E +++ E E E ++ ERE++
Sbjct: 678 KRLAEQREQERREQERREQERREQE-RREQERREQERQLAEQERRREQERLQAERELQER 736
Query: 412 SETVSAAQLLLVENSSEK 429
+ + + L EK
Sbjct: 737 EKALRLQKEQLQRELEEK 754
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 48.1 bits (113), Expect = 3e-05
Identities = 70/364 (19%), Positives = 157/364 (43%), Gaps = 27/364 (7%)
Query: 62 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRL 121
+ ++ ++++ + E K L+++ E + EEE R + E+ E + E++R + +W R
Sbjct: 393 RKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERN 452
Query: 122 EAKD-LERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTF 180
++ L +RN+E E++ +L+ + + L+ E + L+ KH ++ Q++
Sbjct: 453 RRQELLNQRNKEQEDIVVLK---AKKKTLEFELEALNDKKHQLE-------GKLQDIRCR 502
Query: 181 ISLWK---EKTNETFE-EVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQL 236
++ + E TN++ E + E + + L E + + P + + + Q Q++ L
Sbjct: 503 LTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHR 562
Query: 237 QELLHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSE 296
L+ LK + + L +Q LD E K + + ++ LK+ + + +
Sbjct: 563 DSLVTLKRALEAKELARQ-HLRDQLDEVEKETRSKLQEIDIFN-NQLKELREIHNKQQLQ 620
Query: 297 TQIGFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTE---------LVKD 347
Q E R L + +++ A K++ V + L ++
Sbjct: 621 KQKSMEAER-LKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEE 679
Query: 348 DVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCERE 407
+ E+++ K+ EE +QE L + E + ++ S+AE+ I +
Sbjct: 680 EKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQEN 739
Query: 408 MKVL 411
+KV+
Sbjct: 740 VKVV 743
Score = 39.7 bits (91), Expect = 0.009
Identities = 75/352 (21%), Positives = 152/352 (43%), Gaps = 54/352 (15%)
Query: 71 KKVTKAERLKLLQEEEERRLKE----EEEARLKYEKEEMERLEIQRIEKEKWHRLE---- 122
KK ER L E+ + L E E+E + E+ E ER E +R E+E+ +LE
Sbjct: 353 KKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQ 412
Query: 123 ---AKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNT 179
++LER+ EE E +ER EA K + E + +W+ + + + QE
Sbjct: 413 LEKQRELERQREE-ERRKEIER--REAAKRELERQRQLEWERNRRQELLNQRNKEQEDIV 469
Query: 180 FISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQEL 239
+ K+ E + +K + ++ ++ L T +++ N + L++ E+
Sbjct: 470 VLKAKKKTLEFELEALNDKKHQLEGKLQDIR-CRLTTQRQEIESTN----KSRELRIAEI 524
Query: 240 LHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQI 299
HL + L+++ + + ++I ++ + +++N HR +
Sbjct: 525 THL------QQQLQESQQM-------LGRLIPEKQILNDQLKQVQQNSLHRDSLVT---- 567
Query: 300 GFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKE 359
+ R L ++A + L D V KE S + E+ D+ N + +E
Sbjct: 568 ---LKRALEAKELARQHLRDQLDEV---------EKETRSKLQEI---DIFNNQLKELRE 612
Query: 360 VEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVL 411
+ +KQQ + ++ E +K +E++ I +++ +EE++ ER+ + L
Sbjct: 613 I--HNKQQLQKQKSMEAERLKQKEQERKI-IELEKQKEEAQRRAQERDKQWL 661
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 48.1 bits (113), Expect = 3e-05
Identities = 70/364 (19%), Positives = 157/364 (43%), Gaps = 27/364 (7%)
Query: 62 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRL 121
+ ++ ++++ + E K L+++ E + EEE R + E+ E + E++R + +W R
Sbjct: 393 RKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERN 452
Query: 122 EAKD-LERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTF 180
++ L +RN+E E++ +L+ + + L+ E + L+ KH ++ Q++
Sbjct: 453 RRQELLNQRNKEQEDIVVLK---AKKKTLEFELEALNDKKHQLE-------GKLQDIRCR 502
Query: 181 ISLWK---EKTNETFE-EVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQL 236
++ + E TN++ E + E + + L E + + P + + + Q Q++ L
Sbjct: 503 LTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHR 562
Query: 237 QELLHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSE 296
L+ LK + + L +Q LD E K + + ++ LK+ + + +
Sbjct: 563 DSLVTLKRALEAKELARQ-HLRDQLDEVEKETRSKLQEIDIFN-NQLKELREIHNKQQLQ 620
Query: 297 TQIGFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTE---------LVKD 347
Q E R L + +++ A K++ V + L ++
Sbjct: 621 KQKSMEAER-LKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEE 679
Query: 348 DVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCERE 407
+ E+++ K+ EE +QE L + E + ++ S+AE+ I +
Sbjct: 680 EKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQEN 739
Query: 408 MKVL 411
+KV+
Sbjct: 740 VKVV 743
Score = 39.7 bits (91), Expect = 0.009
Identities = 75/352 (21%), Positives = 152/352 (43%), Gaps = 54/352 (15%)
Query: 71 KKVTKAERLKLLQEEEERRLKE----EEEARLKYEKEEMERLEIQRIEKEKWHRLE---- 122
KK ER L E+ + L E E+E + E+ E ER E +R E+E+ +LE
Sbjct: 353 KKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQ 412
Query: 123 ---AKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNT 179
++LER+ EE E +ER EA K + E + +W+ + + + QE
Sbjct: 413 LEKQRELERQREE-ERRKEIER--REAAKRELERQRQLEWERNRRQELLNQRNKEQEDIV 469
Query: 180 FISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQEL 239
+ K+ E + +K + ++ ++ L T +++ N + L++ E+
Sbjct: 470 VLKAKKKTLEFELEALNDKKHQLEGKLQDIR-CRLTTQRQEIESTN----KSRELRIAEI 524
Query: 240 LHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQI 299
HL + L+++ + + ++I ++ + +++N HR +
Sbjct: 525 THL------QQQLQESQQM-------LGRLIPEKQILNDQLKQVQQNSLHRDSLVT---- 567
Query: 300 GFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKE 359
+ R L ++A + L D V KE S + E+ D+ N + +E
Sbjct: 568 ---LKRALEAKELARQHLRDQLDEV---------EKETRSKLQEI---DIFNNQLKELRE 612
Query: 360 VEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVL 411
+ +KQQ + ++ E +K +E++ I +++ +EE++ ER+ + L
Sbjct: 613 I--HNKQQLQKQKSMEAERLKQKEQERKI-IELEKQKEEAQRRAQERDKQWL 661
>gi|116174778 centrosome spindle pole associated protein 1 isoform b
[Homo sapiens]
Length = 1221
Score = 48.1 bits (113), Expect = 3e-05
Identities = 51/191 (26%), Positives = 92/191 (48%), Gaps = 25/191 (13%)
Query: 69 KKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEE-----MERLEIQRIEKEKWHRL-- 121
K+++ + ERL++ +E+EERRL E+ AR++ E EE E+ E QR++ E+ RL
Sbjct: 747 KQREEAERERLRIAEEKEERRLAEQR-ARIQQEYEEEQEKKREKEEEQRLKNEEHIRLAE 805
Query: 122 -EAKDLERRNEELEELYLLE---------RCFPEAEKLKQETKLLSQWKHYIQCDGSPDP 171
K+ ER+ +E EE Y L+ E + ++Q + ++ ++ I P
Sbjct: 806 ERQKEAERKKKEEEEKYNLQLQHYCERDNLIGEETKHMRQPSPIVPALQNKIASKLQRPP 865
Query: 172 SVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQE 231
SV + +FI + + + K L E+ K +++E Q ++ +E
Sbjct: 866 SVDSIIRSFIH--ESSMSRAQSPPVPARKNQLRAEEEKKNVIMELSEMRKQ----LRSEE 919
Query: 232 SILQLQELLHL 242
LQ + LLH+
Sbjct: 920 RRLQ-ERLLHM 929
Score = 40.8 bits (94), Expect = 0.004
Identities = 39/171 (22%), Positives = 78/171 (45%), Gaps = 15/171 (8%)
Query: 83 QEEEERRLKEEEEARLKYEKEEME------RLEIQRIEKEKWHRLEAKDLERRNEELEEL 136
Q EE+++ +E E RL+ +E+ E R IQ+ +E+ + K+ E+R + E +
Sbjct: 742 QIEEKKQREEAERERLRIAEEKEERRLAEQRARIQQEYEEEQEKKREKEEEQRLKNEEHI 801
Query: 137 YLLERCFPEAEKLK--QETKLLSQWKHYIQCDG--SPDPSVAQEMNTFISLWKEKTNETF 192
L E EAE+ K +E K Q +HY + D + ++ + + + K
Sbjct: 802 RLAEERQKEAERKKKEEEEKYNLQLQHYCERDNLIGEETKHMRQPSPIVPALQNKIASKL 861
Query: 193 EEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQES----ILQLQEL 239
+ ++ + I + ++PP + KN ++ +E I++L E+
Sbjct: 862 QRPPSVDSIIRSFIHESSMSRAQSPPVPAR-KNQLRAEEEKKNVIMELSEM 911
>gi|116174789 centrosome spindle pole associated protein 1 isoform a
[Homo sapiens]
Length = 1256
Score = 48.1 bits (113), Expect = 3e-05
Identities = 51/191 (26%), Positives = 92/191 (48%), Gaps = 25/191 (13%)
Query: 69 KKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEE-----MERLEIQRIEKEKWHRL-- 121
K+++ + ERL++ +E+EERRL E+ AR++ E EE E+ E QR++ E+ RL
Sbjct: 782 KQREEAERERLRIAEEKEERRLAEQR-ARIQQEYEEEQEKKREKEEEQRLKNEEHIRLAE 840
Query: 122 -EAKDLERRNEELEELYLLE---------RCFPEAEKLKQETKLLSQWKHYIQCDGSPDP 171
K+ ER+ +E EE Y L+ E + ++Q + ++ ++ I P
Sbjct: 841 ERQKEAERKKKEEEEKYNLQLQHYCERDNLIGEETKHMRQPSPIVPALQNKIASKLQRPP 900
Query: 172 SVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQE 231
SV + +FI + + + K L E+ K +++E Q ++ +E
Sbjct: 901 SVDSIIRSFIH--ESSMSRAQSPPVPARKNQLRAEEEKKNVIMELSEMRKQ----LRSEE 954
Query: 232 SILQLQELLHL 242
LQ + LLH+
Sbjct: 955 RRLQ-ERLLHM 964
Score = 40.8 bits (94), Expect = 0.004
Identities = 39/171 (22%), Positives = 78/171 (45%), Gaps = 15/171 (8%)
Query: 83 QEEEERRLKEEEEARLKYEKEEME------RLEIQRIEKEKWHRLEAKDLERRNEELEEL 136
Q EE+++ +E E RL+ +E+ E R IQ+ +E+ + K+ E+R + E +
Sbjct: 777 QIEEKKQREEAERERLRIAEEKEERRLAEQRARIQQEYEEEQEKKREKEEEQRLKNEEHI 836
Query: 137 YLLERCFPEAEKLK--QETKLLSQWKHYIQCDG--SPDPSVAQEMNTFISLWKEKTNETF 192
L E EAE+ K +E K Q +HY + D + ++ + + + K
Sbjct: 837 RLAEERQKEAERKKKEEEEKYNLQLQHYCERDNLIGEETKHMRQPSPIVPALQNKIASKL 896
Query: 193 EEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQES----ILQLQEL 239
+ ++ + I + ++PP + KN ++ +E I++L E+
Sbjct: 897 QRPPSVDSIIRSFIHESSMSRAQSPPVPAR-KNQLRAEEEKKNVIMELSEM 946
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 47.8 bits (112), Expect = 3e-05
Identities = 56/230 (24%), Positives = 104/230 (45%), Gaps = 16/230 (6%)
Query: 77 ERLKLLQE---EEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLE---AKDLERRN 130
ERL+ +E E+E RL+E EE + E+ E+ E R ++E+ H E + ER
Sbjct: 234 ERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLR 293
Query: 131 EELEELYLLERCFPEAEK--LKQETKLLSQWKHYIQCDGSP-DPSVAQEMNTFISLWKEK 187
E+ E L E E E+ +QE +L Q + + + P + +E+ + +E+
Sbjct: 294 EQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEKLPGQERLLEEVEKLLE--QER 351
Query: 188 TNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFGVA 247
E E ++E+ +++ + E L+ L L + +Q E + +L+ +L L +
Sbjct: 352 RQEEQERLLERERLLEEVEELLEQERLRQQDERLWQQETLQELERLRELERMLELGWEAL 411
Query: 248 TEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSET 297
E + S +L++ N + ++ V LKK+ R SE+
Sbjct: 412 YEQRAEPRSGFEELNNENKSTLQLEQQV-----KELKKSGGAEEPRGSES 456
Score = 37.0 bits (84), Expect = 0.061
Identities = 29/88 (32%), Positives = 47/88 (53%), Gaps = 4/88 (4%)
Query: 72 KVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNE 131
+V + L LL +E RL+E+EE RL+ ++E + E + E+E+ R + + L + E
Sbjct: 183 EVENNQMLSLLNRRQEERLREQEE-RLREQEERLREQEERLCEQEERLREQEERLREQEE 241
Query: 132 ELEELYLLERCFPEAEKL-KQETKLLSQ 158
L E ER E+L +QE +L Q
Sbjct: 242 RLCEQE--ERLREHEERLCEQEERLCEQ 267
Score = 33.1 bits (74), Expect = 0.88
Identities = 51/223 (22%), Positives = 104/223 (46%), Gaps = 22/223 (9%)
Query: 58 GQGPKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEK--EEMERLEIQ--RI 113
G+ +A+ ++ + + + L+E+EER ++EE R + E+ E+ ERL Q R+
Sbjct: 177 GRQLQAEVENNQMLSLLNRRQEERLREQEERLREQEERLREQEERLCEQEERLREQEERL 236
Query: 114 EKEKWHRLEAKDLERRNEE--LEELYLL----ERCFPEAEKL-KQETKLLSQWKHYIQCD 166
+++ E ++ R +EE E+ L ER + E+L +QE +L Q + + +
Sbjct: 237 REQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQE 296
Query: 167 G--SPDPSVAQEMNTFISLWKEKTNETFEEVIEKSKV-----VLNLIEKLKFILLETPPC 219
+E + +E+ E E + E+ K+ +L +EK LLE
Sbjct: 297 ERLCEQEERLREQEERLCEQEERLREQEERLCEQEKLPGQERLLEEVEK----LLEQERR 352
Query: 220 DLQDKNIIQYQESILQLQELLHLKFGVATEILLKQASTLADLD 262
+ + +++ + + +++ELL + + L Q TL +L+
Sbjct: 353 QEEQERLLERERLLEEVEELLEQERLRQQDERLWQQETLQELE 395
Score = 29.6 bits (65), Expect = 9.8
Identities = 34/115 (29%), Positives = 56/115 (48%), Gaps = 18/115 (15%)
Query: 71 KKVTKAERLKLLQEEEERRLKEEEEARLKYEKEE-MERLEIQRIEKEKWHRLEAKDLERR 129
++V K + QEE+ER L+ E RL E EE +E+ +++ ++ W + ++LER
Sbjct: 341 EEVEKLLEQERRQEEQERLLERE---RLLEEVEELLEQERLRQQDERLWQQETLQELERL 397
Query: 130 NEELEELYLL-------ERCFPEA--EKLKQETK----LLSQWKHYIQCDGSPDP 171
ELE + L +R P + E+L E K L Q K + G+ +P
Sbjct: 398 -RELERMLELGWEALYEQRAEPRSGFEELNNENKSTLQLEQQVKELKKSGGAEEP 451
>gi|239508778 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 123
Score = 47.8 bits (112), Expect = 3e-05
Identities = 32/77 (41%), Positives = 44/77 (57%), Gaps = 7/77 (9%)
Query: 64 KKSGSKKKKVTKAERLKLLQEEEERRL-----KEEEEARLKYEKEEMERLEIQRIEKEKW 118
+K KKKK + E+ K +EEE++R K+EEE R + E+EE E E + EKE+
Sbjct: 37 RKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEE--EKEEG 94
Query: 119 HRLEAKDLERRNEELEE 135
R + K RR EE EE
Sbjct: 95 RRRKKKKKRRRKEEEEE 111
Score = 40.0 bits (92), Expect = 0.007
Identities = 27/89 (30%), Positives = 47/89 (52%), Gaps = 1/89 (1%)
Query: 64 KKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEA 123
KK KKK+ + E + +EEEE+ K +E+ + K KE+ ++ + + EK K E
Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEK-RKEKEKKKKTKETEKRKEKEEEE 59
Query: 124 KDLERRNEELEELYLLERCFPEAEKLKQE 152
K +R+ ++ +E E E E+ K+E
Sbjct: 60 KKRKRKRKKKKEEEEREEEEEEEEEEKEE 88
Score = 38.5 bits (88), Expect = 0.021
Identities = 26/70 (37%), Positives = 42/70 (60%), Gaps = 7/70 (10%)
Query: 62 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRL 121
K K+ KK+K + K +EEEER +EEEE + EKEE E+ E +R +K+K R
Sbjct: 53 KEKEEEEKKRK----RKRKKKKEEEEREEEEEEE---EEEKEEEEKEEGRRRKKKKKRRR 105
Query: 122 EAKDLERRNE 131
+ ++ E++ +
Sbjct: 106 KEEEEEKKKK 115
Score = 36.6 bits (83), Expect = 0.080
Identities = 21/63 (33%), Positives = 35/63 (55%)
Query: 62 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRL 121
K +K KKKK + + +EEEE+ +E+EE R + +K++ R E + +K+K R
Sbjct: 60 KKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKKKRRRK 119
Query: 122 EAK 124
K
Sbjct: 120 TKK 122
Score = 34.7 bits (78), Expect = 0.30
Identities = 21/68 (30%), Positives = 42/68 (61%), Gaps = 1/68 (1%)
Query: 69 KKKKVTKAERLKLLQEEEERRLK-EEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLE 127
++K+ + E+ K ++E+E++ K +E E R + E+EE +R ++ +KE+ R E ++ E
Sbjct: 23 EEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEE 82
Query: 128 RRNEELEE 135
+E EE
Sbjct: 83 EEEKEEEE 90
Score = 34.3 bits (77), Expect = 0.40
Identities = 22/64 (34%), Positives = 34/64 (53%), Gaps = 2/64 (3%)
Query: 346 KDDVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCE 405
K K EK KE EEE K+++R +EEE + EEE+ + E K +EE K +
Sbjct: 43 KKKTKETEKR--KEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKK 100
Query: 406 REMK 409
++ +
Sbjct: 101 KKRR 104
Score = 30.0 bits (66), Expect = 7.5
Identities = 19/63 (30%), Positives = 35/63 (55%), Gaps = 10/63 (15%)
Query: 64 KKSGSKKKKVTKAERLKLLQEEEE----------RRLKEEEEARLKYEKEEMERLEIQRI 113
K+ +KKK + ER + +EEEE RR K++++ R K E+EE ++ ++
Sbjct: 61 KRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKKKRRRKT 120
Query: 114 EKE 116
+K+
Sbjct: 121 KKK 123
Score = 29.6 bits (65), Expect = 9.8
Identities = 20/64 (31%), Positives = 30/64 (46%)
Query: 343 ELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAI 402
E +++ K K K+ EEE +++E +EEE K E + + K EEE E
Sbjct: 54 EKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKK 113
Query: 403 KCER 406
K R
Sbjct: 114 KKRR 117
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 47.8 bits (112), Expect = 3e-05
Identities = 99/445 (22%), Positives = 191/445 (42%), Gaps = 76/445 (17%)
Query: 46 SSQQWLSLPGPGGQGPKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEM 105
+ QQ S+P Q + S + KV + KL E+ +++ E+E L+ KEE
Sbjct: 279 AQQQAASVPILEEQIINLEAEVSAQDKVLREAENKL---EQSQKMVIEKEQSLQESKEEC 335
Query: 106 ERLEIQRIEKEKWHRLEAKDLER-RNEELEELYLLERCFPE--------AEKLKQETKLL 156
+L++ +E+ K + K ER RNE L L + F + EK++ E ++L
Sbjct: 336 IKLKVDLLEQTK----QGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEIL 391
Query: 157 SQWKHYIQCDGSPDPSVAQEMNTF---ISLWKEKTNETFEE-----------VIEKSKVV 202
++ C+ + + + + + + KEK + EE ++ S+V+
Sbjct: 392 E--RNLTNCE-KENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVM 448
Query: 203 LNLIEKLKFIL-LETPPCDLQDKNIIQYQESILQLQELLHLKFGVATE----ILLKQAST 257
L E + IL LE+ +L++K+ I ++ + E LK VA + L +Q
Sbjct: 449 AQLTESRQSILKLES---ELENKDEI-LRDKFSLMNENRELKVRVAAQNERLDLCQQEIE 504
Query: 258 LADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQ---IGFEIPRILATSDIAV 314
+ ++ ++EK+I + ++ +++ FS + IG L S++ +
Sbjct: 505 SSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRI 564
Query: 315 RLLHTHYDHVSALHP---------------VSTPSKEYTSAVTELVK-------DDVKNV 352
+L + + LH S S + +S TE VK + VK+
Sbjct: 565 KLAIKEAE-IQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQ 623
Query: 353 -EKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAI------KCE 405
+ ++K+ E+E ++ G ++ + I++E E D++V M+ + + I K
Sbjct: 624 NQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKAS 683
Query: 406 REMKVLSE-TVSAAQLLLVENSSEK 429
K+ SE T +QLL +E E+
Sbjct: 684 NSSKLESEMTKKCSQLLTLEKQLEE 708
Score = 31.6 bits (70), Expect = 2.6
Identities = 20/78 (25%), Positives = 40/78 (51%)
Query: 77 ERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEEL 136
ER + +E E +KE+E+ KE ++ + R+ +E+ + E R+++++
Sbjct: 1221 ERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQ 1280
Query: 137 YLLERCFPEAEKLKQETK 154
+ER E E +KQ +K
Sbjct: 1281 REIERLSSELEDMKQLSK 1298
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 47.4 bits (111), Expect = 5e-05
Identities = 34/112 (30%), Positives = 59/112 (52%), Gaps = 9/112 (8%)
Query: 53 LPGPGGQGPKAKKSGSKKKKVTKAERLKLLQEE-------EERRLKEE--EEARLKYEKE 103
LP GP ++ +++++ + +R K L+ E E RL+ E E RL+ E+
Sbjct: 127 LPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERL 186
Query: 104 EMERLEIQRIEKEKWHRLEAKDLERRNEELEELYLLERCFPEAEKLKQETKL 155
E E+LE +R E+E+ RLE ++ R E LE L+R E ++ ++ +L
Sbjct: 187 EQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERL 238
Score = 45.1 bits (105), Expect = 2e-04
Identities = 40/150 (26%), Positives = 71/150 (47%), Gaps = 12/150 (8%)
Query: 52 SLPGPGGQGPKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQ 111
+LP Q P ++G ++++ R Q +E++R KE E RL+ E+ E ERLE +
Sbjct: 119 TLPRQNSQLPAQVQNGPSQEELEIQRR----QLQEQQRQKELERERLERERMERERLERE 174
Query: 112 RIEKEKWHRLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDP 171
R+E+E LER E E+L + E+L+++ +L Q + Q +
Sbjct: 175 RLERE--------RLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRER 226
Query: 172 SVAQEMNTFISLWKEKTNETFEEVIEKSKV 201
QE L +E+ +E +E+ ++
Sbjct: 227 QERQERERLERLERERQERERQEQLEREQL 256
Score = 45.1 bits (105), Expect = 2e-04
Identities = 39/112 (34%), Positives = 62/112 (55%), Gaps = 5/112 (4%)
Query: 75 KAERLKLLQEEEER-RLKEEEEARLKYEKEEMERLEIQ-RIEK-EKWHRLEAKDLERR-N 130
+ ER +L +E ER RL++E+ R + E+E ERLE Q R+E+ E+ R E D ER+
Sbjct: 170 RLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQER 229
Query: 131 EELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDP-SVAQEMNTFI 181
+E E L LER E E+ +Q + +W+ + + P SV +N+ +
Sbjct: 230 QERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVL 281
Score = 41.6 bits (96), Expect = 0.002
Identities = 22/70 (31%), Positives = 44/70 (62%), Gaps = 1/70 (1%)
Query: 62 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRL 121
+ ++ +++++ + ERL+ QE ER+ + + E + + E+E +ERLE +R E+E+ +L
Sbjct: 193 RERQERERQERLERQERLER-QERLERQERLDRERQERQERERLERLERERQERERQEQL 251
Query: 122 EAKDLERRNE 131
E + LE E
Sbjct: 252 EREQLEWERE 261
Score = 32.7 bits (73), Expect = 1.2
Identities = 15/55 (27%), Positives = 34/55 (61%)
Query: 69 KKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEA 123
+++++ + ERL ++E + R + E R + E+E E+LE +++E E+ R+ +
Sbjct: 212 RQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISS 266
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 47.4 bits (111), Expect = 5e-05
Identities = 34/112 (30%), Positives = 59/112 (52%), Gaps = 9/112 (8%)
Query: 53 LPGPGGQGPKAKKSGSKKKKVTKAERLKLLQEE-------EERRLKEE--EEARLKYEKE 103
LP GP ++ +++++ + +R K L+ E E RL+ E E RL+ E+
Sbjct: 127 LPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERL 186
Query: 104 EMERLEIQRIEKEKWHRLEAKDLERRNEELEELYLLERCFPEAEKLKQETKL 155
E E+LE +R E+E+ RLE ++ R E LE L+R E ++ ++ +L
Sbjct: 187 EQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERL 238
Score = 45.1 bits (105), Expect = 2e-04
Identities = 40/150 (26%), Positives = 71/150 (47%), Gaps = 12/150 (8%)
Query: 52 SLPGPGGQGPKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQ 111
+LP Q P ++G ++++ R Q +E++R KE E RL+ E+ E ERLE +
Sbjct: 119 TLPRQNSQLPAQVQNGPSQEELEIQRR----QLQEQQRQKELERERLERERMERERLERE 174
Query: 112 RIEKEKWHRLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDP 171
R+E+E LER E E+L + E+L+++ +L Q + Q +
Sbjct: 175 RLERE--------RLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRER 226
Query: 172 SVAQEMNTFISLWKEKTNETFEEVIEKSKV 201
QE L +E+ +E +E+ ++
Sbjct: 227 QERQERERLERLERERQERERQEQLEREQL 256
Score = 45.1 bits (105), Expect = 2e-04
Identities = 39/112 (34%), Positives = 62/112 (55%), Gaps = 5/112 (4%)
Query: 75 KAERLKLLQEEEER-RLKEEEEARLKYEKEEMERLEIQ-RIEK-EKWHRLEAKDLERR-N 130
+ ER +L +E ER RL++E+ R + E+E ERLE Q R+E+ E+ R E D ER+
Sbjct: 170 RLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQER 229
Query: 131 EELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDP-SVAQEMNTFI 181
+E E L LER E E+ +Q + +W+ + + P SV +N+ +
Sbjct: 230 QERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVL 281
Score = 41.6 bits (96), Expect = 0.002
Identities = 22/70 (31%), Positives = 44/70 (62%), Gaps = 1/70 (1%)
Query: 62 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRL 121
+ ++ +++++ + ERL+ QE ER+ + + E + + E+E +ERLE +R E+E+ +L
Sbjct: 193 RERQERERQERLERQERLER-QERLERQERLDRERQERQERERLERLERERQERERQEQL 251
Query: 122 EAKDLERRNE 131
E + LE E
Sbjct: 252 EREQLEWERE 261
Score = 32.7 bits (73), Expect = 1.2
Identities = 15/55 (27%), Positives = 34/55 (61%)
Query: 69 KKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEA 123
+++++ + ERL ++E + R + E R + E+E E+LE +++E E+ R+ +
Sbjct: 212 RQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISS 266
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 47.4 bits (111), Expect = 5e-05
Identities = 83/368 (22%), Positives = 168/368 (45%), Gaps = 62/368 (16%)
Query: 78 RLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEELY 137
R + + E + R E E + KE+ ++ + KE+ R D++ RNEE+E+L
Sbjct: 2099 RFQPISEHQTR----EVEQLANHLKEKTDKCSELLLSKEQLQR----DIQERNEEIEKLE 2150
Query: 138 LLERCFPEAEKLKQET-KLLSQWKHYIQCDGSPDPSVAQEMNTFISLWKEKTNETFEEVI 196
R +A + +T + + KH+ + P E++ + L E+ + +
Sbjct: 2151 FRVRELEQALLVSADTFQKVEDRKHFGAVEAKP------ELSLEVQLQAER-----DAID 2199
Query: 197 EKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFGVATEILLKQAS 256
K K + NL E+L+ E L++KN E + QL L EI K+++
Sbjct: 2200 RKEKEITNLEEQLEQFREE-----LENKN-----EEVQQLHMQL--------EIQKKEST 2241
Query: 257 T-LADLDSGNMEKVIKD--ENVTLYVWANLKKNPRHRSVRFSETQIGFEIPRILATSDIA 313
T L +L+ N K+ KD E + L + + + + + V F + +I+ ++
Sbjct: 2242 TRLQELEQEN--KLFKDDMEKLGLAIKESDAMSTQDQHVLFG------KFAQIIQEKEVE 2293
Query: 314 VRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHL 373
+ L+ + ++T +K EL++D +E +S ++E ++ R +
Sbjct: 2294 IDQLNEQVTKLQQQLKITTDNK-VIEEKNELIRDLETQIECLMS---DQECVKRNREEEI 2349
Query: 374 IQEEEI--KVEEEQGDIEVKMS----SAEEESEAIKCEREMKVLSETVSAAQLLLVENSS 427
Q E+ K+++E +I K S S EE++++K + ++ V++E ++ Q VE ++
Sbjct: 2350 EQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDV-VIAEKLALEQ--QVETAN 2406
Query: 428 EKPDFFED 435
E+ F ++
Sbjct: 2407 EEMTFMKN 2414
Score = 37.0 bits (84), Expect = 0.061
Identities = 43/219 (19%), Positives = 92/219 (42%), Gaps = 33/219 (15%)
Query: 220 DLQDKNIIQYQESILQLQELLHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYV 279
+L++ + E + QLQE E +KQ + + N+++ ++++ T+
Sbjct: 177 ELEEMRVTYGTEGLQQLQEF---------EAAIKQRDGIITQLTANLQQARREKDETMRE 227
Query: 280 WANLKKNPRHRSVRFSETQIGFEIPRILATSDIAVRLLH------THYDHVSA----LHP 329
+ L + + ++F + Q E R S A LL TH + L
Sbjct: 228 FLELTEQSQKLQIQFQQLQAS-ETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLED 286
Query: 330 VSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIE 389
+++T ++ L ++ +K E K+VE +K++ IQE+E +E E
Sbjct: 287 YQKKKEDFTMQISFL-QEKIKVYEMEQDKKVENSNKEE------IQEKETIIE------E 333
Query: 390 VKMSSAEEESEAIKCEREMKVLSETVSAAQLLLVENSSE 428
+ EEE + ++ + ++ + + Q +V+ + E
Sbjct: 334 LNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQE 372
Score = 37.0 bits (84), Expect = 0.061
Identities = 48/197 (24%), Positives = 93/197 (47%), Gaps = 34/197 (17%)
Query: 81 LLQEEEERRLKEEE--EARLKYEKEEMERLEIQRIEKEKWHRLEAKD--LERRNEELEEL 136
L QEE+E+ E+E E +LK E E + E + +EK+ +LEA++ L+ + LE++
Sbjct: 731 LRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDM 790
Query: 137 YLLERCFPEAEKL------KQETKLLSQWKHYI------------QCDGSPDPSVAQEMN 178
+ + E+L K ++K S W+ I QC + + ++ N
Sbjct: 791 LKIHTPVSQEERLIFLDSIKSKSK-DSVWEKEIEILIEENEDLKQQCI-QLNEEIEKQRN 848
Query: 179 TFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQE 238
TF S ++ ++E+ E+ +L + + L+ D ++K ++Y+ + L E
Sbjct: 849 TF-SFAEKNFEVNYQELQEEYACLLKVKDDLE---------DSKNKQELEYKSKLKALNE 898
Query: 239 LLHLKFGVATEILLKQA 255
LHL+ T + +K +
Sbjct: 899 ELHLQRINPTTVKMKSS 915
Score = 37.0 bits (84), Expect = 0.061
Identities = 79/397 (19%), Positives = 154/397 (38%), Gaps = 65/397 (16%)
Query: 95 EARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEELYL-----LERCFPEAEKL 149
E +L+ E++ ++R E + E+ ++LE +NEE+++L++ + ++L
Sbjct: 2188 EVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2247
Query: 150 KQETKLLSQWKHYI-QCDGSPDPSVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEK 208
+QE KL + D Q+ + + + E E+ + ++ V L ++
Sbjct: 2248 EQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQ 2307
Query: 209 LKFIL--------------LETP-PCDLQDKNIIQ--YQESILQLQELLH------LKFG 245
LK LET C + D+ ++ +E I QL E++ G
Sbjct: 2308 LKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIG 2367
Query: 246 VATEILLKQASTLADLDSGNMEKVIKDE----------NVTLYVWANLKKNPRHRSVRFS 295
T + S AD ++ VI ++ N + N+ K + + +
Sbjct: 2368 QKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLT 2427
Query: 296 ETQIGFEIPR--ILATSDIAVRLLHTHYDHVSALHP-----------VSTPSKEYTSAVT 342
+ + R + I ++ DH+S P S ++ Y +
Sbjct: 2428 QELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFE 2487
Query: 343 ELVKDDVKNVEKAISKEVEEESKQQERGSHLIQ-EEEIKVEEEQGDIEVKMSSAEEESEA 401
E K + N+E ++ ++ ES + L Q ++IK +EQG E +M
Sbjct: 2488 ENGKGSIINLE---TRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK------ 2538
Query: 402 IKCEREMKVLSETVSAAQL--LLVENSSEKPDFFEDN 436
K K++ E V+AA + + +E E F +DN
Sbjct: 2539 -KIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDN 2574
Score = 35.8 bits (81), Expect = 0.14
Identities = 62/330 (18%), Positives = 133/330 (40%), Gaps = 26/330 (7%)
Query: 77 ERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKD-LERRNEELEE 135
E++K+ + E++++++ + ++ ++ +E L + IE+EK LE KD L ++ L E
Sbjct: 303 EKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEK-KTLELKDKLTTADKLLGE 361
Query: 136 LYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLWKEKTNETFEEV 195
L E+ + +++K L+ K Q + + Q M T L K ++ E
Sbjct: 362 LQ--EQIVQKNQEIKNMKLELTNSK---QKERQSSEEIKQLMGTVEELQKRNHKDSQFET 416
Query: 196 IEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQL-QELLHLKFGVATEILLKQ 254
++ KL+ + E Y + I+Q+ QEL+ E+ +
Sbjct: 417 DIVQRMEQETQRKLEQLRAELDE---------MYGQQIVQMKQELIRQHMAQMEEMKTRH 467
Query: 255 ASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPRILATSDIAV 314
+ + + ++ + L A + N + + + ++ E+ IL
Sbjct: 468 KGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ 527
Query: 315 RLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISK--EVEEESKQQERGSH 372
R L + +S S+E + + + + +A VE+ + S
Sbjct: 528 RQLEDLVEELSF-------SREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASE 580
Query: 373 LIQEEEIKVEEEQGDIEVKMSSAEEESEAI 402
+E E+K E E + ++K+ E+E A+
Sbjct: 581 SRKELELKHEAEVTNYKIKLEMLEKEKNAV 610
Score = 34.3 bits (77), Expect = 0.40
Identities = 59/331 (17%), Positives = 145/331 (43%), Gaps = 45/331 (13%)
Query: 83 QEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEELYLLERC 142
Q +EER L ++ +K E +E+ +Q EK +LE +C
Sbjct: 1968 QIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEV-----------------QC 2010
Query: 143 FPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLWKEKTNETFEEVIEKSKVV 202
+AEK++ + L + ++ D V ++++ FI L +EK E ++ ++++ +
Sbjct: 2011 --QAEKVRDD---LQKQVKALEID------VEEQVSRFIELEQEKNTELM-DLRQQNQAL 2058
Query: 203 LNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFGVATEILLKQASTLADLD 262
+EK++ L E ++++ Q + L+ Q + +F +E ++ LA+
Sbjct: 2059 EKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLAN-- 2116
Query: 263 SGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGF-EIPRILATSDIAVRLL--HT 319
++++ + L L+++ + R+ + + E+ + L S + +
Sbjct: 2117 --HLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRK 2174
Query: 320 HYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAIS---KEVEEESKQQERGSHLIQE 376
H+ V A +S + +D + EK I+ +++E+ ++ E + +Q+
Sbjct: 2175 HFGAVEAKPELS------LEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQ 2228
Query: 377 EEIKVEEEQGDIEVKMSSAEEESEAIKCERE 407
+++E ++ + ++ E+E++ K + E
Sbjct: 2229 LHMQLEIQKKESTTRLQELEQENKLFKDDME 2259
Score = 32.3 bits (72), Expect = 1.5
Identities = 81/389 (20%), Positives = 156/389 (40%), Gaps = 61/389 (15%)
Query: 59 QGPKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEE---------EARLKYEKEEMERLE 109
Q K KK + +V K EE E E +A L KE+ E+L+
Sbjct: 2657 QREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQ 2716
Query: 110 IQRIEKEKWHRLEAKDLERRNEEL----EELYLLERCFPEAEKLKQETKLLSQWKHYIQC 165
+ + KE KDL + + L E+L +LE+ E E QE+K C
Sbjct: 2717 EELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEK---EDETEVQESKK--------AC 2765
Query: 166 DGSPDP-----SVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCD 220
P P S+A + + + + +N+T + +++ + + +NL + C
Sbjct: 2766 MFEPLPIKLSKSIASQTDGTLKI--SSSNQTPQILVKNAGIQINLQSE----------CS 2813
Query: 221 LQD--KNIIQYQESILQLQELLHLKFGVATEILLKQASTLADLDSGNME-----KVIKDE 273
++ + I Q+ E I ++QEL A EIL ++ +++ ++ E +++K+E
Sbjct: 2814 SEEVTEIISQFTEKIEKMQEL------HAAEILDMESRHISETETLKREHYVAVQLLKEE 2867
Query: 274 NVTLYVWANLKKNPRHRSVRFSETQIGFEIPRILATSDIAVRLLHTHYDHVSALHPVSTP 333
TL ++ S+ ++ I ++ + + H S
Sbjct: 2868 CGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEG 2927
Query: 334 SKEYTSAVTELVKDDVKNVEKAISKEVEE-----ESKQQERGSHLIQE-EEIKVEEEQGD 387
E + + T+ +K + +A+ E + ES + H IQ+ E +EE +
Sbjct: 2928 RGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAY 2987
Query: 388 IEVKMSSAEEESEAIKCEREMKVLSETVS 416
I +SS ++ ++ +RE +V + S
Sbjct: 2988 INT-ISSLKDLITKMQLQREAEVYDSSQS 3015
Score = 30.4 bits (67), Expect = 5.7
Identities = 62/338 (18%), Positives = 137/338 (40%), Gaps = 80/338 (23%)
Query: 122 EAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFI 181
+ KD++ + + E +L++ +K+ +E K+ + IQ + + + + N I
Sbjct: 2521 QIKDMQEQGQF--ETEMLQKKIVNLQKIVEE-KVAAALVSQIQLEAVQEYAKFCQDNQTI 2577
Query: 182 SLWKEKTN-ETFEEVIEK-------------SKVVLNLIEKLKFILLETPPCDLQDKNII 227
S E+TN + ++ E S++ ++E ++LE ++ +KN++
Sbjct: 2578 SSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVL 2637
Query: 228 QYQESILQLQELLHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNP 287
+ ++ +L+LQ+LL GN +K + E K++P
Sbjct: 2638 EKEKKLLELQKLL----------------------EGNEKKQREKEK---------KRSP 2666
Query: 288 RHRSVRFSETQIGFEIPRILATSDIAVRLLHTH-----YDHVSALHPVSTPSKEYTSAVT 342
+ V + T+ L H++ ++ + AL S +K ++
Sbjct: 2667 QDVEVLKTTTE-----------------LFHSNEESGFFNELEALRAESVATKAELASYK 2709
Query: 343 ELVKDDVKNVEKAISKEVEEESKQQERG---SHLIQ-EEEIKVEEEQGDIEVKMSSAEEE 398
E + K E+ + KE S Q++ HL + +E++ + E++ + EV+ S
Sbjct: 2710 EKAE---KLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACM 2766
Query: 399 SEAIKCEREMKVLSETVSAAQLLLVENSSEKPDFFEDN 436
E + + + S+T L + +S++ P N
Sbjct: 2767 FEPLPIKLSKSIASQTDGT---LKISSSNQTPQILVKN 2801
Score = 30.4 bits (67), Expect = 5.7
Identities = 33/120 (27%), Positives = 56/120 (46%), Gaps = 6/120 (5%)
Query: 93 EEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEELYLLERCFPEAEKLKQE 152
E L EKE++E E +EKEK LE + L NE+ + +R + E LK
Sbjct: 2617 EMHTSLILEKEQVEIAEKNVLEKEK-KLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTT 2675
Query: 153 TKLL---SQWKHYIQCDGSPDPSVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEKL 209
T+L + + + + SVA + ++ +KEK + EE++ K + +L + L
Sbjct: 2676 TELFHSNEESGFFNELEALRAESVATKAE--LASYKEKAEKLQEELLVKETNMTSLQKDL 2733
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 47.0 bits (110), Expect = 6e-05
Identities = 77/368 (20%), Positives = 156/368 (42%), Gaps = 52/368 (14%)
Query: 70 KKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERR 129
+ K+ KAE L++ E+ +E E ++K E+E L+ + E+ K L+
Sbjct: 668 RSKLDKAEDQHLVEMEDTLNKLQEAEIKVK----ELEVLQAKCNEQTKVIDNFTSQLKAT 723
Query: 130 NEELEELYLLERCFPEAE----KLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLWK 185
E+L +L L + E + KL+Q+ + + +++ + + + S A + + +
Sbjct: 724 EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRE 783
Query: 186 EKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLK-- 243
K E + E S+V L ++L+ + + + + Q S+ + LH K
Sbjct: 784 LKLTNLQENLSEVSQVKETLEKELQILKEKFAEAS---EEAVSVQRSMQETVNKLHQKEE 840
Query: 244 -FGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGFE 302
F + + L K LAD+++ EK ++E + ++ ++ +
Sbjct: 841 QFNMLSSDLEKLRENLADMEAKFREKDEREEQLIK-----------------AKEKLEND 883
Query: 303 IPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKA--ISKEV 360
I I+ S D+ S L ++ + V EL K E A + K +
Sbjct: 884 IAEIMKMSG----------DNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSI 933
Query: 361 E------EESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSET 414
E E+S+Q+ H +EE+ ++E + D+E KM ++ + + +K E + SET
Sbjct: 934 EDMTVKAEQSQQEAAKKH--EEEKKELERKLSDLEKKMETSHNQCQELKARYE-RATSET 990
Query: 415 VSAAQLLL 422
+ + +L
Sbjct: 991 KTKHEEIL 998
Score = 38.1 bits (87), Expect = 0.027
Identities = 72/373 (19%), Positives = 152/373 (40%), Gaps = 57/373 (15%)
Query: 74 TKAERLKLLQEEEERRLKEEEEARLKYEKEEME--RLEIQRIEKEKWHRLEAKDLERRNE 131
T+ E+++L + E L+ ++++ +EME R ++ ++ KEK + LEA + + +
Sbjct: 615 TQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEA--IRSKLD 672
Query: 132 ELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLWKEKTNET 191
+ E+ +L+E + QE ++ + +Q K NE
Sbjct: 673 KAEDQHLVE--MEDTLNKLQEAEIKVKELEVLQA---------------------KCNE- 708
Query: 192 FEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFGVATEIL 251
++KV+ N +LK + D K + + + +L++ L A E
Sbjct: 709 ------QTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLE-----AAEKQ 757
Query: 252 LKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSV--RFSETQIGFEIPRILAT 309
+K + +S + ++ NL++N S E ++ +
Sbjct: 758 IKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEA 817
Query: 310 SDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQER 369
S+ AV + + + V+ LH +S ++EK + E+K +E+
Sbjct: 818 SEEAVSVQRSMQETVNKLHQKEEQFNMLSS-----------DLEKLRENLADMEAKFREK 866
Query: 370 GSHLIQEEEIKVEEE-QGDI-EVKMSSAEEESEAIKCEREMKVLSETVSAAQLLLVENSS 427
+E+ IK +E+ + DI E+ S + S+ K E+++ V QL L + ++
Sbjct: 867 DER--EEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTK-AN 923
Query: 428 EKPDFFEDNVVDL 440
E F + ++ D+
Sbjct: 924 ENASFLQKSIEDM 936
Score = 29.6 bits (65), Expect = 9.8
Identities = 23/62 (37%), Positives = 37/62 (59%), Gaps = 3/62 (4%)
Query: 77 ERLKLLQE-EEERRLKEEEEARLKYEKEEMERLEIQRI-EKEKWHRLEAKDLERRNEELE 134
E+++LL + EEE+R E+ + R++ E LE+ + EK + LE KDL R +E+
Sbjct: 423 EKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELE-KDLALRVQEVA 481
Query: 135 EL 136
EL
Sbjct: 482 EL 483
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 47.0 bits (110), Expect = 6e-05
Identities = 77/368 (20%), Positives = 156/368 (42%), Gaps = 52/368 (14%)
Query: 70 KKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERR 129
+ K+ KAE L++ E+ +E E ++K E+E L+ + E+ K L+
Sbjct: 703 RSKLDKAEDQHLVEMEDTLNKLQEAEIKVK----ELEVLQAKCNEQTKVIDNFTSQLKAT 758
Query: 130 NEELEELYLLERCFPEAE----KLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLWK 185
E+L +L L + E + KL+Q+ + + +++ + + + S A + + +
Sbjct: 759 EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRE 818
Query: 186 EKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLK-- 243
K E + E S+V L ++L+ + + + + Q S+ + LH K
Sbjct: 819 LKLTNLQENLSEVSQVKETLEKELQILKEKFAEAS---EEAVSVQRSMQETVNKLHQKEE 875
Query: 244 -FGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGFE 302
F + + L K LAD+++ EK ++E + ++ ++ +
Sbjct: 876 QFNMLSSDLEKLRENLADMEAKFREKDEREEQLIK-----------------AKEKLEND 918
Query: 303 IPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKA--ISKEV 360
I I+ S D+ S L ++ + V EL K E A + K +
Sbjct: 919 IAEIMKMSG----------DNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSI 968
Query: 361 E------EESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSET 414
E E+S+Q+ H +EE+ ++E + D+E KM ++ + + +K E + SET
Sbjct: 969 EDMTVKAEQSQQEAAKKH--EEEKKELERKLSDLEKKMETSHNQCQELKARYE-RATSET 1025
Query: 415 VSAAQLLL 422
+ + +L
Sbjct: 1026 KTKHEEIL 1033
Score = 38.1 bits (87), Expect = 0.027
Identities = 72/373 (19%), Positives = 152/373 (40%), Gaps = 57/373 (15%)
Query: 74 TKAERLKLLQEEEERRLKEEEEARLKYEKEEME--RLEIQRIEKEKWHRLEAKDLERRNE 131
T+ E+++L + E L+ ++++ +EME R ++ ++ KEK + LEA + + +
Sbjct: 650 TQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEA--IRSKLD 707
Query: 132 ELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLWKEKTNET 191
+ E+ +L+E + QE ++ + +Q K NE
Sbjct: 708 KAEDQHLVE--MEDTLNKLQEAEIKVKELEVLQA---------------------KCNE- 743
Query: 192 FEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFGVATEIL 251
++KV+ N +LK + D K + + + +L++ L A E
Sbjct: 744 ------QTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLE-----AAEKQ 792
Query: 252 LKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSV--RFSETQIGFEIPRILAT 309
+K + +S + ++ NL++N S E ++ +
Sbjct: 793 IKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEA 852
Query: 310 SDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQER 369
S+ AV + + + V+ LH +S ++EK + E+K +E+
Sbjct: 853 SEEAVSVQRSMQETVNKLHQKEEQFNMLSS-----------DLEKLRENLADMEAKFREK 901
Query: 370 GSHLIQEEEIKVEEE-QGDI-EVKMSSAEEESEAIKCEREMKVLSETVSAAQLLLVENSS 427
+E+ IK +E+ + DI E+ S + S+ K E+++ V QL L + ++
Sbjct: 902 DER--EEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTK-AN 958
Query: 428 EKPDFFEDNVVDL 440
E F + ++ D+
Sbjct: 959 ENASFLQKSIEDM 971
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 46.2 bits (108), Expect = 1e-04
Identities = 81/394 (20%), Positives = 152/394 (38%), Gaps = 52/394 (13%)
Query: 62 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEME-RLEIQRIEKEKWHR 120
+ + S +KK++ E++KL E+ + K+ L KEE LE++R+ +EK
Sbjct: 1918 QVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRL 1977
Query: 121 LEAKDLERRNEELEELYLLERCFPEAE----KLKQETKLLSQWKHYIQCDGSPDPSVAQE 176
+E K+ + E E + E E KL E K+L + + S E
Sbjct: 1978 VEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLE 2037
Query: 177 MNTFISLW---KEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESI 233
++ + K + ++I+K + + KL IL ++ + Q + +
Sbjct: 2038 FTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKM 2097
Query: 234 LQLQELLHLK-----------------FGVATEILLKQASTLADLD---SGNMEKVIKDE 273
+++ L +K F L K LA + M ++I E
Sbjct: 2098 TKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKE 2157
Query: 274 NVTLYVWANLKKNPRHRSVRFS-ETQIGFEIPRILA-------------TSDIAVRLLHT 319
+ L + +H V E + G E ++ D +
Sbjct: 2158 EKMTEEESKLAR--KHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSS 2215
Query: 320 HYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEI 379
D V S+E+ S E + D+++ E S+E EE +++ER ++EEE
Sbjct: 2216 QVDEVE--------SEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEE 2267
Query: 380 KVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSE 413
+ +EE+ E ++ EEE + K E++ + + E
Sbjct: 2268 ERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQE 2301
Score = 40.8 bits (94), Expect = 0.004
Identities = 82/369 (22%), Positives = 152/369 (41%), Gaps = 45/369 (12%)
Query: 64 KKSGSKKKKVTKAERL--KLLQEEEERRLKEEEE----ARLKYEKEEMERLEIQRIEKEK 117
KK+ + K+V R K +EE E+RL +EEE A K EE E ++++ E+
Sbjct: 1461 KKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEE 1520
Query: 118 WHR-----LEAKDLERRNEELEELYLLERCFPEAEKLKQET-------KLLSQWKHYIQC 165
W + L +K E++ ++ EE+ L E E E+ +Q+ + +W +
Sbjct: 1521 WKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRK 1580
Query: 166 DGSPDPSVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKN 225
+ AQE ++ +EK + ++ ++ + + K+ D+
Sbjct: 1581 RARAEKKRAQEERK-LAQEEEKLAQEERQLAQEERKLAQAYVKIT----------QDDRE 1629
Query: 226 IIQYQESILQLQELLHL---KFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWAN 282
+ Q + Q +E L K E L ++ LA EKV ++E
Sbjct: 1630 MAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAK----KWEKVAREEEKLA----- 1680
Query: 283 LKKNPRHRSVRFSETQIGFEIPRILATSDIAVRLLHTHYDHVS-ALHPVSTPSKEYTSAV 341
KK + V+ Q E+P+ D + L + + + +S +E
Sbjct: 1681 -KKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEE 1739
Query: 342 TELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEA 401
+LV++ K E+ + + E K E + L QEEE+ ++E++ + K EEE E
Sbjct: 1740 GKLVEEKKKLAEEEEALAWQRE-KLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEE-ER 1797
Query: 402 IKCEREMKV 410
+ +RE +
Sbjct: 1798 LGRKREQLI 1806
Score = 40.4 bits (93), Expect = 0.006
Identities = 28/77 (36%), Positives = 47/77 (61%), Gaps = 11/77 (14%)
Query: 83 QEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEELYLLERC 142
+E EE ++EEEE R E+EE E ++++ E+EK + K E++ EE++E E
Sbjct: 2255 EEREEEEVREEEEERK--EEEEGEEKQVEKEEEEK----KKKKKEKKKEEVQE---KEEV 2305
Query: 143 FPEAEKL--KQETKLLS 157
F E E++ ++ET+ LS
Sbjct: 2306 FEEKEEIMSEEETESLS 2322
Score = 35.8 bits (81), Expect = 0.14
Identities = 57/245 (23%), Positives = 109/245 (44%), Gaps = 46/245 (18%)
Query: 68 SKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEM----------ERLEIQRIEKEK 117
S K++ E KL+ EE+++L EEEEA L +++E++ E L IQ EK
Sbjct: 1729 SWKEEELNQEEGKLV--EEKKKLAEEEEA-LAWQREKLSEEETKLAQEEELLIQEKEKLA 1785
Query: 118 WHR----LEAKDLERRNEELEELYL-----LERCFPEAEKLKQETKLLSQWKHYIQCDGS 168
H+ E + L R+ E+L E + ER E+L + +L Q K+ Q
Sbjct: 1786 QHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQ---- 1841
Query: 169 PDPSVAQEMNTF------ISLWKEKTNETFEEVIEK-------SKVVLNLIEKL----KF 211
++AQE + KE+ + +++++ +K++ + EKL +
Sbjct: 1842 EKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKET 1901
Query: 212 ILLETPPCDLQDKNIIQYQESILQLQELL---HLKFGVATEILLKQASTLADLDSGNMEK 268
++ + +K ++Q ++S+ + QE L +K + ++ + +LD EK
Sbjct: 1902 VIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEK 1961
Query: 269 VIKDE 273
+ E
Sbjct: 1962 ALNLE 1966
Score = 35.8 bits (81), Expect = 0.14
Identities = 28/96 (29%), Positives = 46/96 (47%), Gaps = 6/96 (6%)
Query: 69 KKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIE------KEKWHRLE 122
++++V + E + +EE E + E+EE K +K+E ++ E+Q E +E E
Sbjct: 2258 EEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEE 2317
Query: 123 AKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQ 158
+ L EE E L E E E LK+E + Q
Sbjct: 2318 TESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQ 2353
Score = 35.0 bits (79), Expect = 0.23
Identities = 87/396 (21%), Positives = 165/396 (41%), Gaps = 58/396 (14%)
Query: 59 QGPKAKKSGSKKKKVTKAERLKLLQ-EEEERRLKEEEEARLKYEKEEMERL-EIQRIEKE 116
QG K + K KA L++ + EE+ RL E +E K E E R ++ ++E+E
Sbjct: 1945 QGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQE 2004
Query: 117 KWHR---LEAKDL--ERRNEELEELYLL---------ERCFPEAE-KLKQETKLLSQWKH 161
+ R LE K L E R +EE + +R F + + KL + ++ L + +
Sbjct: 2005 LFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRE 2064
Query: 162 YIQCDGSPDPSVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDL 221
+ S +P+ ++ + + +E I+ +K+ L K + + +E D+
Sbjct: 2065 SL----SKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDI 2120
Query: 222 QDKNIIQYQESILQLQELLHLKFGVAT----------EILLKQASTLADLDS-----GNM 266
++ + + + + + ++ L K E + ++ S LA S
Sbjct: 2121 KEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEE 2180
Query: 267 EKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPRILATSDIAVRLLHTHYDHVSA 326
E I++E V + LK+ R R E + G + P+ +S + H+
Sbjct: 2181 EGGIEEEEVIPF----LKRRWRKRK----EAKRG-DKPKEKFSSQVDEVESEEHFSEEME 2231
Query: 327 LHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQG 386
+E S+ E +++ + E+ +E EEE K++E G +E++++ EEE+
Sbjct: 2232 SLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEG----EEKQVEKEEEEK 2287
Query: 387 DIEVKMSSAE---------EESEAIKCEREMKVLSE 413
+ K E EE E I E E + LS+
Sbjct: 2288 KKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSD 2323
Score = 33.5 bits (75), Expect = 0.68
Identities = 24/69 (34%), Positives = 40/69 (57%), Gaps = 5/69 (7%)
Query: 346 KDDVKNVEKAISKEVEEESKQQ-ERGSHLIQEEEIKVEEEQGDI---EVKMSSAEEESEA 401
K++ + EK + KE EE+ K++ E+ +QE+E +V EE+ +I E S ++EE E
Sbjct: 2270 KEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKE-EVFEEKEEIMSEEETESLSDEEEEE 2328
Query: 402 IKCEREMKV 410
C E +V
Sbjct: 2329 ESCSLEEEV 2337
Score = 33.1 bits (74), Expect = 0.88
Identities = 22/79 (27%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 64 KKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEI-QRIEKEKWHRLE 122
KK K+KK + + + + EE+E + EEE L E+EE E + + +++EK +
Sbjct: 2287 KKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKK 2346
Query: 123 AKDLERRNEELEELYLLER 141
K + + + + L ER
Sbjct: 2347 EKQFKLQEQRRKSLRGRER 2365
Score = 32.7 bits (73), Expect = 1.2
Identities = 41/200 (20%), Positives = 86/200 (43%), Gaps = 20/200 (10%)
Query: 62 KAKKSGSKKKKVTKAERLKLLQEEEE-------------RRLKEEEEARLKYEKEEMERL 108
K +K ++ K+ + +L +EEE RR ++ +EA+ + +E
Sbjct: 2156 KEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSS 2215
Query: 109 EIQRIEKEKWHRLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGS 168
++ +E E+ E + L E+ E L E E E+ ++E ++ + + + +
Sbjct: 2216 QVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEG 2275
Query: 169 PDPSVAQEMNTFISLWKEKTNETF---EEVIEKSKVVLN--LIEKLKFILLETPPCDLQD 223
+ V +E KEK E EEV E+ + +++ E L E C L++
Sbjct: 2276 EEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEE 2335
Query: 224 KNIIQYQESILQLQELLHLK 243
+ + ++ IL+ ++ L+
Sbjct: 2336 E--VDREKEILKKEKQFKLQ 2353
Score = 32.0 bits (71), Expect = 2.0
Identities = 44/183 (24%), Positives = 80/183 (43%), Gaps = 26/183 (14%)
Query: 61 PKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHR 120
P+ +++ ++K E +L + EE KE EE+ + E + +E++K
Sbjct: 1701 PQREQNLDWQEKELAQELEELEWDMEELSWKE----------EELNQEEGKLVEEKKKLA 1750
Query: 121 LEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTF 180
E + L + E+L E E KL QE +LL Q K + P + +
Sbjct: 1751 EEEEALAWQREKLSE---------EETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGR- 1800
Query: 181 ISLWKEKTNETFEEVIEKSKVVLNLIEKL---KFILLETPPCDLQDKNIIQYQESILQLQ 237
+E+ E ++ +K + +N +E+L K IL + + KN+ Q +E + Q +
Sbjct: 1801 ---KREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRK 1857
Query: 238 ELL 240
E L
Sbjct: 1858 ENL 1860
Score = 30.8 bits (68), Expect = 4.4
Identities = 35/157 (22%), Positives = 72/157 (45%), Gaps = 33/157 (21%)
Query: 62 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEE---EEARL-----------------KYE 101
K +K G K+++TK ER + EE L+E+ +E +L +++
Sbjct: 1409 KERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWK 1468
Query: 102 KEEMERLEIQRIEKEKWHRLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKH 161
+ E + + KE+W + ++ E+ ++ E+L PE E L+++ KL +W+
Sbjct: 1469 QVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKL------SPEEEMLQEDKKL--KWEE 1520
Query: 162 YIQCDGSPDPSVAQEMNTFISLWKEKTNETFEEVIEK 198
+ Q + S ++E +K++ T EE + +
Sbjct: 1521 WKQVWENMLSSKSKEQQ-----YKDEEEVTLEEEVSR 1552
Score = 30.4 bits (67), Expect = 5.7
Identities = 24/77 (31%), Positives = 38/77 (49%), Gaps = 4/77 (5%)
Query: 353 EKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLS 412
EK +++E+EE E S +EEE+ +E+G + + EE EA+ +RE
Sbjct: 1711 EKELAQELEELEWDMEELSW--KEEELN--QEEGKLVEEKKKLAEEEEALAWQREKLSEE 1766
Query: 413 ETVSAAQLLLVENSSEK 429
ET A + L+ EK
Sbjct: 1767 ETKLAQEEELLIQEKEK 1783
>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
Length = 1139
Score = 46.2 bits (108), Expect = 1e-04
Identities = 33/121 (27%), Positives = 68/121 (56%), Gaps = 10/121 (8%)
Query: 326 ALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEI-----K 380
A+ P+ +PSKE + V+D + +E K E+++K +E H IQ E++ K
Sbjct: 72 AVPPLPSPSKE-EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSK 130
Query: 381 VEEEQGDIEVKMSSAEEES-EAIKC-EREMKVLSETVSAAQLLLV--ENSSEKPDFFEDN 436
++E+Q D++ ++ A +E+ EA++ ER M+ +++T A ++ + E + E+ + +
Sbjct: 131 MQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQE 190
Query: 437 V 437
V
Sbjct: 191 V 191
Score = 37.4 bits (85), Expect = 0.047
Identities = 84/388 (21%), Positives = 157/388 (40%), Gaps = 40/388 (10%)
Query: 53 LPGPGGQGPKAKKSGSKKKKVTKAERLKLLQEEEERRLKE-EEEARLKYEKEEMERLEIQ 111
L PG P S SK+++ +A+ L ++ E RLK E++A+LK E+E+ +IQ
Sbjct: 67 LTSPGAVPPLP--SPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLK----ELEKHKIQ 120
Query: 112 RIEKEKWHR--------LEAKDLERRNEELEELYLLERCFPE----AEKLKQET---KLL 156
+ ++W L+ + E R E E L ER E A+ ++ T ++
Sbjct: 121 LEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMA 180
Query: 157 SQWKHYIQCDGSPDPSVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIE---KLKFIL 213
+ +Q + E+ T + + K + E + S + L E +LK L
Sbjct: 181 EERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDAL 240
Query: 214 LETPPCDLQDK----NIIQYQESILQLQELLHLKFGVATEILLKQASTLADLDSGNMEKV 269
+ +K + + E Q E++ + E L + ST+ +L +
Sbjct: 241 VRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAAL 300
Query: 270 IKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPRILATSDIAVRLLHTHYDHVSALHP 329
+E V + NL + R +R ET E + ++ T + L
Sbjct: 301 GAEEMVEMLTDRNLNLEEKVRELR--ETVGDLEAMNEM-NDELQENARETELELREQLDM 357
Query: 330 VSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQG--- 386
+E V E ++ V + ++ I K + + Q+ L ++E VE +Q
Sbjct: 358 AGARVREAQKRV-EAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPP 416
Query: 387 ---DIEVKMSSAEEESEAIKCE-REMKV 410
D ++K + + ++AI+ E R+M+V
Sbjct: 417 ETFDFKIKFAETKAHAKAIEMELRQMEV 444
Score = 35.4 bits (80), Expect = 0.18
Identities = 40/138 (28%), Positives = 62/138 (44%), Gaps = 22/138 (15%)
Query: 56 PGGQGPKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEK 115
P P ++ + + ++T AE L L E+ E +KE +++ LK + EE+ ++
Sbjct: 784 PSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKS-LKIKGEELSEANVRLSLL 842
Query: 116 EKWHRLEAKDLERRNEE----LEELYLL----ERCFP-------------EAEKLKQETK 154
EK AKD + R E+ LEE L E+ F EAEK + + +
Sbjct: 843 EKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQR 902
Query: 155 LLSQWKHYIQCDGSPDPS 172
L SQ K I+ P PS
Sbjct: 903 LNSQSKRTIEGLRGPPPS 920
>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
Length = 1253
Score = 46.2 bits (108), Expect = 1e-04
Identities = 33/121 (27%), Positives = 68/121 (56%), Gaps = 10/121 (8%)
Query: 326 ALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEI-----K 380
A+ P+ +PSKE + V+D + +E K E+++K +E H IQ E++ K
Sbjct: 186 AVPPLPSPSKE-EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSK 244
Query: 381 VEEEQGDIEVKMSSAEEES-EAIKC-EREMKVLSETVSAAQLLLV--ENSSEKPDFFEDN 436
++E+Q D++ ++ A +E+ EA++ ER M+ +++T A ++ + E + E+ + +
Sbjct: 245 MQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQE 304
Query: 437 V 437
V
Sbjct: 305 V 305
Score = 37.4 bits (85), Expect = 0.047
Identities = 84/388 (21%), Positives = 157/388 (40%), Gaps = 40/388 (10%)
Query: 53 LPGPGGQGPKAKKSGSKKKKVTKAERLKLLQEEEERRLKE-EEEARLKYEKEEMERLEIQ 111
L PG P S SK+++ +A+ L ++ E RLK E++A+LK E+E+ +IQ
Sbjct: 181 LTSPGAVPPLP--SPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLK----ELEKHKIQ 234
Query: 112 RIEKEKWHR--------LEAKDLERRNEELEELYLLERCFPE----AEKLKQET---KLL 156
+ ++W L+ + E R E E L ER E A+ ++ T ++
Sbjct: 235 LEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMA 294
Query: 157 SQWKHYIQCDGSPDPSVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIE---KLKFIL 213
+ +Q + E+ T + + K + E + S + L E +LK L
Sbjct: 295 EERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDAL 354
Query: 214 LETPPCDLQDK----NIIQYQESILQLQELLHLKFGVATEILLKQASTLADLDSGNMEKV 269
+ +K + + E Q E++ + E L + ST+ +L +
Sbjct: 355 VRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAAL 414
Query: 270 IKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPRILATSDIAVRLLHTHYDHVSALHP 329
+E V + NL + R +R ET E + ++ T + L
Sbjct: 415 GAEEMVEMLTDRNLNLEEKVRELR--ETVGDLEAMNEM-NDELQENARETELELREQLDM 471
Query: 330 VSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQG--- 386
+E V E ++ V + ++ I K + + Q+ L ++E VE +Q
Sbjct: 472 AGARVREAQKRV-EAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPP 530
Query: 387 ---DIEVKMSSAEEESEAIKCE-REMKV 410
D ++K + + ++AI+ E R+M+V
Sbjct: 531 ETFDFKIKFAETKAHAKAIEMELRQMEV 558
Score = 35.4 bits (80), Expect = 0.18
Identities = 40/138 (28%), Positives = 62/138 (44%), Gaps = 22/138 (15%)
Query: 56 PGGQGPKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEK 115
P P ++ + + ++T AE L L E+ E +KE +++ LK + EE+ ++
Sbjct: 898 PSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKS-LKIKGEELSEANVRLSLL 956
Query: 116 EKWHRLEAKDLERRNEE----LEELYLL----ERCFP-------------EAEKLKQETK 154
EK AKD + R E+ LEE L E+ F EAEK + + +
Sbjct: 957 EKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQR 1016
Query: 155 LLSQWKHYIQCDGSPDPS 172
L SQ K I+ P PS
Sbjct: 1017 LNSQSKRTIEGLRGPPPS 1034
>gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
Length = 1144
Score = 46.2 bits (108), Expect = 1e-04
Identities = 33/121 (27%), Positives = 68/121 (56%), Gaps = 10/121 (8%)
Query: 326 ALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEI-----K 380
A+ P+ +PSKE + V+D + +E K E+++K +E H IQ E++ K
Sbjct: 72 AVPPLPSPSKE-EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSK 130
Query: 381 VEEEQGDIEVKMSSAEEES-EAIKC-EREMKVLSETVSAAQLLLV--ENSSEKPDFFEDN 436
++E+Q D++ ++ A +E+ EA++ ER M+ +++T A ++ + E + E+ + +
Sbjct: 131 MQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQE 190
Query: 437 V 437
V
Sbjct: 191 V 191
Score = 37.4 bits (85), Expect = 0.047
Identities = 84/388 (21%), Positives = 157/388 (40%), Gaps = 40/388 (10%)
Query: 53 LPGPGGQGPKAKKSGSKKKKVTKAERLKLLQEEEERRLKE-EEEARLKYEKEEMERLEIQ 111
L PG P S SK+++ +A+ L ++ E RLK E++A+LK E+E+ +IQ
Sbjct: 67 LTSPGAVPPLP--SPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLK----ELEKHKIQ 120
Query: 112 RIEKEKWHR--------LEAKDLERRNEELEELYLLERCFPE----AEKLKQET---KLL 156
+ ++W L+ + E R E E L ER E A+ ++ T ++
Sbjct: 121 LEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMA 180
Query: 157 SQWKHYIQCDGSPDPSVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIE---KLKFIL 213
+ +Q + E+ T + + K + E + S + L E +LK L
Sbjct: 181 EERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDAL 240
Query: 214 LETPPCDLQDK----NIIQYQESILQLQELLHLKFGVATEILLKQASTLADLDSGNMEKV 269
+ +K + + E Q E++ + E L + ST+ +L +
Sbjct: 241 VRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAAL 300
Query: 270 IKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPRILATSDIAVRLLHTHYDHVSALHP 329
+E V + NL + R +R ET E + ++ T + L
Sbjct: 301 GAEEMVEMLTDRNLNLEEKVRELR--ETVGDLEAMNEM-NDELQENARETELELREQLDM 357
Query: 330 VSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQG--- 386
+E V E ++ V + ++ I K + + Q+ L ++E VE +Q
Sbjct: 358 AGARVREAQKRV-EAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPP 416
Query: 387 ---DIEVKMSSAEEESEAIKCE-REMKV 410
D ++K + + ++AI+ E R+M+V
Sbjct: 417 ETFDFKIKFAETKAHAKAIEMELRQMEV 444
Score = 35.4 bits (80), Expect = 0.18
Identities = 40/138 (28%), Positives = 62/138 (44%), Gaps = 22/138 (15%)
Query: 56 PGGQGPKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEK 115
P P ++ + + ++T AE L L E+ E +KE +++ LK + EE+ ++
Sbjct: 784 PSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKS-LKIKGEELSEANVRLSLL 842
Query: 116 EKWHRLEAKDLERRNEE----LEELYLL----ERCFP-------------EAEKLKQETK 154
EK AKD + R E+ LEE L E+ F EAEK + + +
Sbjct: 843 EKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQR 902
Query: 155 LLSQWKHYIQCDGSPDPS 172
L SQ K I+ P PS
Sbjct: 903 LNSQSKRTIEGLRGPPPS 920
>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
Length = 1278
Score = 46.2 bits (108), Expect = 1e-04
Identities = 33/121 (27%), Positives = 68/121 (56%), Gaps = 10/121 (8%)
Query: 326 ALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEI-----K 380
A+ P+ +PSKE + V+D + +E K E+++K +E H IQ E++ K
Sbjct: 206 AVPPLPSPSKE-EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSK 264
Query: 381 VEEEQGDIEVKMSSAEEES-EAIKC-EREMKVLSETVSAAQLLLV--ENSSEKPDFFEDN 436
++E+Q D++ ++ A +E+ EA++ ER M+ +++T A ++ + E + E+ + +
Sbjct: 265 MQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQE 324
Query: 437 V 437
V
Sbjct: 325 V 325
Score = 37.4 bits (85), Expect = 0.047
Identities = 84/388 (21%), Positives = 157/388 (40%), Gaps = 40/388 (10%)
Query: 53 LPGPGGQGPKAKKSGSKKKKVTKAERLKLLQEEEERRLKE-EEEARLKYEKEEMERLEIQ 111
L PG P S SK+++ +A+ L ++ E RLK E++A+LK E+E+ +IQ
Sbjct: 201 LTSPGAVPPLP--SPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLK----ELEKHKIQ 254
Query: 112 RIEKEKWHR--------LEAKDLERRNEELEELYLLERCFPE----AEKLKQET---KLL 156
+ ++W L+ + E R E E L ER E A+ ++ T ++
Sbjct: 255 LEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMA 314
Query: 157 SQWKHYIQCDGSPDPSVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIE---KLKFIL 213
+ +Q + E+ T + + K + E + S + L E +LK L
Sbjct: 315 EERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDAL 374
Query: 214 LETPPCDLQDK----NIIQYQESILQLQELLHLKFGVATEILLKQASTLADLDSGNMEKV 269
+ +K + + E Q E++ + E L + ST+ +L +
Sbjct: 375 VRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAAL 434
Query: 270 IKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPRILATSDIAVRLLHTHYDHVSALHP 329
+E V + NL + R +R ET E + ++ T + L
Sbjct: 435 GAEEMVEMLTDRNLNLEEKVRELR--ETVGDLEAMNEM-NDELQENARETELELREQLDM 491
Query: 330 VSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQG--- 386
+E V E ++ V + ++ I K + + Q+ L ++E VE +Q
Sbjct: 492 AGARVREAQKRV-EAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPP 550
Query: 387 ---DIEVKMSSAEEESEAIKCE-REMKV 410
D ++K + + ++AI+ E R+M+V
Sbjct: 551 ETFDFKIKFAETKAHAKAIEMELRQMEV 578
Score = 35.4 bits (80), Expect = 0.18
Identities = 40/138 (28%), Positives = 62/138 (44%), Gaps = 22/138 (15%)
Query: 56 PGGQGPKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEK 115
P P ++ + + ++T AE L L E+ E +KE +++ LK + EE+ ++
Sbjct: 918 PSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKS-LKIKGEELSEANVRLSLL 976
Query: 116 EKWHRLEAKDLERRNEE----LEELYLL----ERCFP-------------EAEKLKQETK 154
EK AKD + R E+ LEE L E+ F EAEK + + +
Sbjct: 977 EKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQR 1036
Query: 155 LLSQWKHYIQCDGSPDPS 172
L SQ K I+ P PS
Sbjct: 1037 LNSQSKRTIEGLRGPPPS 1054
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.132 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,317,590
Number of Sequences: 37866
Number of extensions: 1346226
Number of successful extensions: 18835
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 279
Number of HSP's successfully gapped in prelim test: 714
Number of HSP's that attempted gapping in prelim test: 8403
Number of HSP's gapped (non-prelim): 6729
length of query: 690
length of database: 18,247,518
effective HSP length: 109
effective length of query: 581
effective length of database: 14,120,124
effective search space: 8203792044
effective search space used: 8203792044
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.