Guide to the Human Genome
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Name: HFE Sequence: fasta or formatted (348aa) NCBI GI: 4504377
Description:

hemochromatosis protein isoform 1 precursor

Referenced in:

Major Disease Loci
HLA and Related Proteins
Iron, Copper, and Arsenic Metabolism
Polymorphism

Other entries for this name:
alt prot [242aa] hemochromatosis protein isoform 3 precursor
alt prot [256aa] hemochromatosis protein isoform 4 precursor
alt prot [334aa] hemochromatosis protein isoform 6 precursor
alt prot [260aa] hemochromatosis protein isoform 7 precursor
alt prot [246aa] hemochromatosis protein isoform 8 precursor
alt prot [325aa] hemochromatosis protein isoform 9 precursor
alt prot [168aa] hemochromatosis protein isoform 10 precursor
alt prot [76aa] hemochromatosis protein isoform 11 precursor
Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             4.9         17           2
 C cysteine            1.4          5           1
 D aspartate           5.2         18           2
 E glutamate           6.6         23           2
 F phenylalanine       3.2         11           1
 G glycine             6.9         24           1
 H histidine           3.7         13           2
 I isoleucine          4.6         16           2
 K lysine              3.4         12           1
 L leucine            12.4         43           4
 M methionine          2.9         10           1
 N asparagine          2.0          7           1
 P proline             5.7         20           2
 Q glutamine           6.6         23           2
 R arginine            6.6         23           2
 S serine              5.7         20           2
 T threonine           4.9         17           2
 V valine              6.6         23           2
 W tryptophan          3.2         11           1
 Y tyrosine            3.4         12           2
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   hemochromatosis protein isoform 1 precursor 
HFE                   0.947   hemochromatosis protein isoform 6 precursor 
HFE                   0.914   hemochromatosis protein isoform 9 precursor 
HFE                   0.670   hemochromatosis protein isoform 7 precursor 
HFE                   0.617   hemochromatosis protein isoform 8 precursor 
HFE                   0.389   hemochromatosis protein isoform 4 precursor 
HFE                   0.386   hemochromatosis protein isoform 10 precursor 
HFE                   0.352   hemochromatosis protein isoform 3 precursor 
MR1                   0.283   major histocompatibility complex, class I-related [Ho...
HLA-A                 0.273   major histocompatibility complex, class I, A precurs...
HLA-B                 0.272   major histocompatibility complex, class I, B precurs...
LOC652614             0.265   PREDICTED: similar to MHC class I antigen 
HLA-C                 0.259   major histocompatibility complex, class I, C precurs...
HLA-G                 0.255   major histocompatibility complex, class I, G precurso...
HLA-F                 0.253   major histocompatibility complex, class I, F isofor...
HLA-F                 0.253   major histocompatibility complex, class I, F isofor...
HLA-E                 0.252   major histocompatibility complex, class I, E precurs...
AZGP1                 0.247   alpha-2-glycoprotein 1, zinc 
MICB                  0.165   MHC class I polypeptide-related sequence B 
MICA                  0.156   MHC class I polypeptide-related sequence A 
FCGRT                 0.146   Fc fragment of IgG, receptor, transporter, alpha [H...
FCGRT                 0.146   Fc fragment of IgG, receptor, transporter, alpha [Hom...
HFE                   0.106   hemochromatosis protein isoform 11 precursor 
HLA-F                 0.097   major histocompatibility complex, class I, F isofor...
LOC100294318          0.090   PREDICTED: similar to major histocompatibility comp...
CD1D                  0.090   CD1D antigen precursor 
LOC100294318          0.090   PREDICTED: similar to major histocompatibility comp...
HLA-DQB1              0.087   major histocompatibility complex, class II, DQ beta...
LOC100133583          0.086   PREDICTED: similar to major histocompatibility comp...
LOC100133583          0.080   PREDICTED: similar to major histocompatibility comp...
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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