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Search of human proteins with 40806175
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40806175 diacylglycerol kinase, theta [Homo sapiens]
(942 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40806175 diacylglycerol kinase, theta [Homo sapiens] 1934 0.0
gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo sapiens] 254 3e-67
gi|22027632 diacylglycerol kinase, beta isoform 1 [Homo sapiens] 254 3e-67
gi|124256482 diacylglycerol kinase gamma isoform 3 [Homo sapiens] 251 2e-66
gi|124256476 diacylglycerol kinase gamma isoform 1 [Homo sapiens] 251 2e-66
gi|4503313 diacylglycerol kinase epsilon [Homo sapiens] 251 3e-66
gi|157688564 diacylglycerol kinase zeta isoform 4 [Homo sapiens] 238 3e-62
gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens] 238 3e-62
gi|41872507 diacylglycerol kinase zeta isoform 2 [Homo sapiens] 238 3e-62
gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens] 238 3e-62
gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 228 3e-59
gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 228 3e-59
gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 228 3e-59
gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 228 3e-59
gi|4758156 diacylglycerol kinase, iota [Homo sapiens] 223 9e-58
gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo sapiens] 205 1e-52
gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo ... 132 2e-30
gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo ... 132 2e-30
gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens] 131 3e-30
gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens] 131 3e-30
gi|62000702 diacylglycerol kinase kappa [Homo sapiens] 130 4e-30
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 69 2e-11
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 69 2e-11
gi|13384594 protein kinase C, gamma [Homo sapiens] 66 2e-10
gi|4506067 protein kinase C, alpha [Homo sapiens] 65 2e-10
gi|4885563 protein kinase C, epsilon [Homo sapiens] 64 5e-10
gi|28557781 protein kinase C, eta [Homo sapiens] 62 3e-09
gi|5453976 protein kinase C, theta [Homo sapiens] 61 4e-09
gi|47157325 protein kinase C, delta [Homo sapiens] 60 7e-09
gi|31377782 protein kinase C, delta [Homo sapiens] 60 7e-09
>gi|40806175 diacylglycerol kinase, theta [Homo sapiens]
Length = 942
Score = 1934 bits (5010), Expect = 0.0
Identities = 942/942 (100%), Positives = 942/942 (100%)
Query: 1 MAAAAEPGARAWLGGGSPRPGSPACSPVLGSGGRARPGPGPGPGPERAGVRAPGPAAAPG 60
MAAAAEPGARAWLGGGSPRPGSPACSPVLGSGGRARPGPGPGPGPERAGVRAPGPAAAPG
Sbjct: 1 MAAAAEPGARAWLGGGSPRPGSPACSPVLGSGGRARPGPGPGPGPERAGVRAPGPAAAPG 60
Query: 61 HSFRKVTLTKPTFCHLCSDFIWGLAGFLCDVCNFMSHEKCLKHVRIPCTSVAPSLVRVPV 120
HSFRKVTLTKPTFCHLCSDFIWGLAGFLCDVCNFMSHEKCLKHVRIPCTSVAPSLVRVPV
Sbjct: 61 HSFRKVTLTKPTFCHLCSDFIWGLAGFLCDVCNFMSHEKCLKHVRIPCTSVAPSLVRVPV 120
Query: 121 AHCFGPRGLHKRKFCAVCRKVLEAPALHCEVCELHLHPDCVPFACSDCRQCHQDGHQDHD 180
AHCFGPRGLHKRKFCAVCRKVLEAPALHCEVCELHLHPDCVPFACSDCRQCHQDGHQDHD
Sbjct: 121 AHCFGPRGLHKRKFCAVCRKVLEAPALHCEVCELHLHPDCVPFACSDCRQCHQDGHQDHD 180
Query: 181 THHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGRLR 240
THHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGRLR
Sbjct: 181 THHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGRLR 240
Query: 241 SLVLPPACVRLLPGGFSKTQSFRIVEAAEPGEGGDGADGSAAVGPGRETQATPESGKQTL 300
SLVLPPACVRLLPGGFSKTQSFRIVEAAEPGEGGDGADGSAAVGPGRETQATPESGKQTL
Sbjct: 241 SLVLPPACVRLLPGGFSKTQSFRIVEAAEPGEGGDGADGSAAVGPGRETQATPESGKQTL 300
Query: 301 KIFDGDDAVRRSQFRLVTVSRLAGAEEVLEAALRAHHIPEDPGHLELCRLPPSSQACDAW 360
KIFDGDDAVRRSQFRLVTVSRLAGAEEVLEAALRAHHIPEDPGHLELCRLPPSSQACDAW
Sbjct: 301 KIFDGDDAVRRSQFRLVTVSRLAGAEEVLEAALRAHHIPEDPGHLELCRLPPSSQACDAW 360
Query: 361 AGGKAGSAVISEEGRSPGSGEATPEAWVIRALPRAQEVLKIYPGWLKVGVAYVSVRVTPK 420
AGGKAGSAVISEEGRSPGSGEATPEAWVIRALPRAQEVLKIYPGWLKVGVAYVSVRVTPK
Sbjct: 361 AGGKAGSAVISEEGRSPGSGEATPEAWVIRALPRAQEVLKIYPGWLKVGVAYVSVRVTPK 420
Query: 421 STARSVVLEVLPLLGRQAESPESFQLVEVAMGCRHVQRTMLMDEQPLLDRLQDIRQMSVR 480
STARSVVLEVLPLLGRQAESPESFQLVEVAMGCRHVQRTMLMDEQPLLDRLQDIRQMSVR
Sbjct: 421 STARSVVLEVLPLLGRQAESPESFQLVEVAMGCRHVQRTMLMDEQPLLDRLQDIRQMSVR 480
Query: 481 QVSQTRFYVAESRDVAPHVSLFVGGLPPGLSPEEYSSLLHEAGATKATVVSVSHIYSSQG 540
QVSQTRFYVAESRDVAPHVSLFVGGLPPGLSPEEYSSLLHEAGATKATVVSVSHIYSSQG
Sbjct: 481 QVSQTRFYVAESRDVAPHVSLFVGGLPPGLSPEEYSSLLHEAGATKATVVSVSHIYSSQG 540
Query: 541 AVVLDVACFAEAERLYMLLKDMAVRGRLLTALVLPDLLHAKLPPDSCPLLVFVNPKSGGL 600
AVVLDVACFAEAERLYMLLKDMAVRGRLLTALVLPDLLHAKLPPDSCPLLVFVNPKSGGL
Sbjct: 541 AVVLDVACFAEAERLYMLLKDMAVRGRLLTALVLPDLLHAKLPPDSCPLLVFVNPKSGGL 600
Query: 601 KGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLVCGGDGTVGWVLGALEET 660
KGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLVCGGDGTVGWVLGALEET
Sbjct: 601 KGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLVCGGDGTVGWVLGALEET 660
Query: 661 RYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLLSVDEADAVLMDRWTILLD 720
RYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLLSVDEADAVLMDRWTILLD
Sbjct: 661 RYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLLSVDEADAVLMDRWTILLD 720
Query: 721 AHEAGSAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQAREEEPGKFTSRLHNKGVYV 780
AHEAGSAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQAREEEPGKFTSRLHNKGVYV
Sbjct: 721 AHEAGSAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQAREEEPGKFTSRLHNKGVYV 780
Query: 781 RVGLQKISHSRSLHKQIRLQVERQEVELPSIEGLIFINIPSWGSGADLWGSDSDTRFEKP 840
RVGLQKISHSRSLHKQIRLQVERQEVELPSIEGLIFINIPSWGSGADLWGSDSDTRFEKP
Sbjct: 781 RVGLQKISHSRSLHKQIRLQVERQEVELPSIEGLIFINIPSWGSGADLWGSDSDTRFEKP 840
Query: 841 RMDDGLLEVVGVTGVVHMGQVQGGLRSGIRIAQGSYFRVTLLKATPVQVDGEPWVQAPGH 900
RMDDGLLEVVGVTGVVHMGQVQGGLRSGIRIAQGSYFRVTLLKATPVQVDGEPWVQAPGH
Sbjct: 841 RMDDGLLEVVGVTGVVHMGQVQGGLRSGIRIAQGSYFRVTLLKATPVQVDGEPWVQAPGH 900
Query: 901 MIISAAGPKVHMLRKAKQKPRRAGTTRDARADAAPAPESDPR 942
MIISAAGPKVHMLRKAKQKPRRAGTTRDARADAAPAPESDPR
Sbjct: 901 MIISAAGPKVHMLRKAKQKPRRAGTTRDARADAAPAPESDPR 942
>gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo sapiens]
Length = 773
Score = 254 bits (648), Expect = 3e-67
Identities = 141/343 (41%), Positives = 200/343 (58%), Gaps = 37/343 (10%)
Query: 584 PDSCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLV 643
P + PLLVFVNPKSGG +G + F+ LLNP QV+ L+ GP+PGL+ F VP FRVL
Sbjct: 434 PGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLA 493
Query: 644 CGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLLS 703
CGGDGTVGWVL +E+ P VAILPLGTGNDL R LRWG GY GE+ +L
Sbjct: 494 CGGDGTVGWVLDCIEKAN---VGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKD 550
Query: 704 VDEADAVLMDRWTILLDAHEAGSAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQARE 763
++ + +++DRW + ++ +++ D P I+ +NY IG+DA ++ FH RE
Sbjct: 551 IENSTEIMLDRWKFEVIPND----KDEKGDPVPYSII--NNYFSIGVDASIAHRFHIMRE 604
Query: 764 EEPGKFTSRLHNKGVYVRVGLQKI--SHSRSLHKQIRLQVERQEVEL--PSIEGLIFINI 819
+ P KF SR+ NK Y G + + + LH+ + ++ + +++L S+EG+ +NI
Sbjct: 605 KHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIAILNI 664
Query: 820 PSWGSGADLW---------------GSDSDT--------RFEKPRMDDGLLEVVGVTGVV 856
PS G++LW GSD T +F + D LLEVVG+ G +
Sbjct: 665 PSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGAM 724
Query: 857 HMGQVQGGLRS-GIRIAQGSYFRVTLLKATPVQVDGEPWVQAP 898
MGQ+ GL+S G R+AQ S + K+ P+Q+DGEPW+Q P
Sbjct: 725 EMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTP 767
Score = 86.3 bits (212), Expect = 1e-16
Identities = 41/131 (31%), Positives = 65/131 (49%), Gaps = 5/131 (3%)
Query: 122 HCFGPRGLHKRKFCAVCRKVLEA---PALHCEVCELHLHPDCVPFACSDCRQCHQDGHQD 178
H + + +K +C +C +L L C C+ +H CV A C + + ++
Sbjct: 245 HVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRN 304
Query: 179 HDTHHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGR 238
D HH+W EGN P+ +C+ C KT L G+ C WC + H+ C++ L PEC G
Sbjct: 305 TDVMHHYWVEGNCPT--KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGP 362
Query: 239 LRSLVLPPACV 249
L+ +LPP +
Sbjct: 363 LKDHILPPTTI 373
Score = 51.2 bits (121), Expect = 4e-06
Identities = 31/115 (26%), Positives = 47/115 (40%), Gaps = 8/115 (6%)
Query: 61 HSFRKVTLTKPTFCHLCSDFIWGLA--GFLCDVCNFMSHEKCLKHVRIPC-TSVAPSLVR 117
H +R KP +C+LC + + G+ G C C + HE+C+ C + S
Sbjct: 245 HVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRN 304
Query: 118 VPVAHCFGPRGLHKRKFCAVCRKVLEA----PALHCEVCELHLHPDCVPFACSDC 168
V H + G K C C K ++ LHC C++ LH C +C
Sbjct: 305 TDVMHHYWVEGNCPTK-CDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPEC 358
>gi|22027632 diacylglycerol kinase, beta isoform 1 [Homo sapiens]
Length = 804
Score = 254 bits (648), Expect = 3e-67
Identities = 141/343 (41%), Positives = 200/343 (58%), Gaps = 37/343 (10%)
Query: 584 PDSCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLV 643
P + PLLVFVNPKSGG +G + F+ LLNP QV+ L+ GP+PGL+ F VP FRVL
Sbjct: 434 PGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLA 493
Query: 644 CGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLLS 703
CGGDGTVGWVL +E+ P VAILPLGTGNDL R LRWG GY GE+ +L
Sbjct: 494 CGGDGTVGWVLDCIEKAN---VGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKD 550
Query: 704 VDEADAVLMDRWTILLDAHEAGSAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQARE 763
++ + +++DRW + ++ +++ D P I+ +NY IG+DA ++ FH RE
Sbjct: 551 IENSTEIMLDRWKFEVIPND----KDEKGDPVPYSII--NNYFSIGVDASIAHRFHIMRE 604
Query: 764 EEPGKFTSRLHNKGVYVRVGLQKI--SHSRSLHKQIRLQVERQEVEL--PSIEGLIFINI 819
+ P KF SR+ NK Y G + + + LH+ + ++ + +++L S+EG+ +NI
Sbjct: 605 KHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIAILNI 664
Query: 820 PSWGSGADLW---------------GSDSDT--------RFEKPRMDDGLLEVVGVTGVV 856
PS G++LW GSD T +F + D LLEVVG+ G +
Sbjct: 665 PSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGAM 724
Query: 857 HMGQVQGGLRS-GIRIAQGSYFRVTLLKATPVQVDGEPWVQAP 898
MGQ+ GL+S G R+AQ S + K+ P+Q+DGEPW+Q P
Sbjct: 725 EMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTP 767
Score = 86.3 bits (212), Expect = 1e-16
Identities = 41/131 (31%), Positives = 65/131 (49%), Gaps = 5/131 (3%)
Query: 122 HCFGPRGLHKRKFCAVCRKVLEA---PALHCEVCELHLHPDCVPFACSDCRQCHQDGHQD 178
H + + +K +C +C +L L C C+ +H CV A C + + ++
Sbjct: 245 HVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRN 304
Query: 179 HDTHHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGR 238
D HH+W EGN P+ +C+ C KT L G+ C WC + H+ C++ L PEC G
Sbjct: 305 TDVMHHYWVEGNCPT--KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGP 362
Query: 239 LRSLVLPPACV 249
L+ +LPP +
Sbjct: 363 LKDHILPPTTI 373
Score = 51.2 bits (121), Expect = 4e-06
Identities = 31/115 (26%), Positives = 47/115 (40%), Gaps = 8/115 (6%)
Query: 61 HSFRKVTLTKPTFCHLCSDFIWGLA--GFLCDVCNFMSHEKCLKHVRIPC-TSVAPSLVR 117
H +R KP +C+LC + + G+ G C C + HE+C+ C + S
Sbjct: 245 HVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRN 304
Query: 118 VPVAHCFGPRGLHKRKFCAVCRKVLEA----PALHCEVCELHLHPDCVPFACSDC 168
V H + G K C C K ++ LHC C++ LH C +C
Sbjct: 305 TDVMHHYWVEGNCPTK-CDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPEC 358
>gi|124256482 diacylglycerol kinase gamma isoform 3 [Homo sapiens]
Length = 752
Score = 251 bits (641), Expect = 2e-66
Identities = 143/335 (42%), Positives = 191/335 (57%), Gaps = 31/335 (9%)
Query: 584 PDSCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLV 643
P + PLLV VNPKSGG +G +L F LLNP QVF+L NGGP PGL+ F P FRVL
Sbjct: 391 PGTHPLLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDFRVLA 450
Query: 644 CGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLLS 703
CGGDGTVGW+L +++ + P VA+LPLGTGNDL R LRWG GY G +L
Sbjct: 451 CGGDGTVGWILDCIDKANF---AKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKD 507
Query: 704 VDEADAVLMDRWTILLDAHEAGSAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQARE 763
++++ V++DRW + + E E + D P I M+NY IG+DA ++ FH RE
Sbjct: 508 IEQSPLVMLDRWHLEVIPRE----EVENGDQVPYSI--MNNYFSIGVDASIAHRFHVMRE 561
Query: 764 EEPGKFTSRLHNKGVYVRVGLQK--ISHSRSLHKQIRLQVERQEVELPSI--EGLIFINI 819
+ P KF SR+ NK Y G + + + LH I L+ + V+L +I EG+ +NI
Sbjct: 562 KHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNI 621
Query: 820 PSWGSGADLWGSDSDTR-----------------FEKPRMDDGLLEVVGVTGVVHMGQVQ 862
PS G +LWG + R F + D LLEVVG+ G + MGQ+
Sbjct: 622 PSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIY 681
Query: 863 GGLRS-GIRIAQGSYFRVTLLKATPVQVDGEPWVQ 896
GL+S G R+AQ + + K P+QVDGEPW+Q
Sbjct: 682 TGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQ 716
Score = 34.7 bits (78), Expect = 0.43
Identities = 13/43 (30%), Positives = 22/43 (51%), Gaps = 2/43 (4%)
Query: 61 HSFRKVTLTKPTFCHLCSDFIWGL--AGFLCDVCNFMSHEKCL 101
H++ KPT+C+ C + G+ G C C + HE+C+
Sbjct: 272 HAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCV 314
>gi|124256476 diacylglycerol kinase gamma isoform 1 [Homo sapiens]
Length = 791
Score = 251 bits (641), Expect = 2e-66
Identities = 143/335 (42%), Positives = 191/335 (57%), Gaps = 31/335 (9%)
Query: 584 PDSCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLV 643
P + PLLV VNPKSGG +G +L F LLNP QVF+L NGGP PGL+ F P FRVL
Sbjct: 430 PGTHPLLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDFRVLA 489
Query: 644 CGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLLS 703
CGGDGTVGW+L +++ + P VA+LPLGTGNDL R LRWG GY G +L
Sbjct: 490 CGGDGTVGWILDCIDKANF---AKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKD 546
Query: 704 VDEADAVLMDRWTILLDAHEAGSAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQARE 763
++++ V++DRW + + E E + D P I M+NY IG+DA ++ FH RE
Sbjct: 547 IEQSPLVMLDRWHLEVIPRE----EVENGDQVPYSI--MNNYFSIGVDASIAHRFHVMRE 600
Query: 764 EEPGKFTSRLHNKGVYVRVGLQK--ISHSRSLHKQIRLQVERQEVELPSI--EGLIFINI 819
+ P KF SR+ NK Y G + + + LH I L+ + V+L +I EG+ +NI
Sbjct: 601 KHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNI 660
Query: 820 PSWGSGADLWGSDSDTR-----------------FEKPRMDDGLLEVVGVTGVVHMGQVQ 862
PS G +LWG + R F + D LLEVVG+ G + MGQ+
Sbjct: 661 PSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIY 720
Query: 863 GGLRS-GIRIAQGSYFRVTLLKATPVQVDGEPWVQ 896
GL+S G R+AQ + + K P+QVDGEPW+Q
Sbjct: 721 TGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQ 755
Score = 55.5 bits (132), Expect = 2e-07
Identities = 33/131 (25%), Positives = 51/131 (38%), Gaps = 7/131 (5%)
Query: 122 HCFGPRGLHKRKFCAVCRKVL---EAPALHCEVCELHLHPDCVPFACSDCRQCHQDGHQD 178
H + + K +C C +L L C C+ +H CV C + + +
Sbjct: 272 HAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKAKRS 331
Query: 179 HDTHHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGR 238
+ H W EGN S +C+ C K+ + C WC + H C L+ C G
Sbjct: 332 GEVMQHAWVEGN--SSVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCE--LSTLCDGGE 387
Query: 239 LRSLVLPPACV 249
LR +L P +
Sbjct: 388 LRDHILLPTSI 398
Score = 37.7 bits (86), Expect = 0.051
Identities = 27/107 (25%), Positives = 39/107 (36%), Gaps = 8/107 (7%)
Query: 61 HSFRKVTLTKPTFCHLCSDFIWGL--AGFLCDVCNFMSHEKCLKHVRIPCTSVAPSLVRV 118
H++ KPT+C+ C + G+ G C C + HE+C+ C R
Sbjct: 272 HAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKAKRS 331
Query: 119 -PVAHCFGPRGLHKRKFCAVCRKVLE----APALHCEVCELHLHPDC 160
V G K C C K ++ A HC C + H C
Sbjct: 332 GEVMQHAWVEGNSSVK-CDRCHKSIKCYQSVTARHCVWCRMTFHRKC 377
>gi|4503313 diacylglycerol kinase epsilon [Homo sapiens]
Length = 567
Score = 251 bits (640), Expect = 3e-66
Identities = 142/330 (43%), Positives = 194/330 (58%), Gaps = 14/330 (4%)
Query: 576 DLLHAKLPPDSCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQ 635
++L +KL PL++ N +SG G LL FR LLNP QVFD+T P+ L L +
Sbjct: 207 EVLASKLGKQWTPLIILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTL 266
Query: 636 VPCF--RVLVCGGDGTVGWVLGALEETRYRLACPE-PSVAILPLGTGNDLGRVLRWGAGY 692
+P + RVLVCGGDGTVGWVL A+++ + + P VA+LPLGTGNDL L WG GY
Sbjct: 267 LPYYSARVLVCGGDGTVGWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDLSNTLGWGTGY 326
Query: 693 SGEDPFS-VLLSVDEADAVLMDRWTILLDAHEAGSAENDTADAEPPKIVQMSNYCGIGID 751
+GE P + VL +V EAD + +DRW + + + PK M+NY +G D
Sbjct: 327 AGEIPVAQVLRNVMEADGIKLDRWKVQV-------TNKGYYNLRKPKEFTMNNYFSVGPD 379
Query: 752 AELSLDFHQAREEEPGKFTSRLHNKGVYVRVGLQK--ISHSRSLHKQIRLQVERQEVELP 809
A ++L+FH RE+ P F+SR+ NK VY+ G + + + L+K++ L+++ + V LP
Sbjct: 380 ALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKVELELDGERVALP 439
Query: 810 SIEGLIFINIPSWGSGADLWGSDSDTRFEKPRMDDGLLEVVGVTGVVHMGQVQGGLRSGI 869
S+EG+I +NI WG G LW D + R DDGLLEVVGV G H Q+Q L +
Sbjct: 440 SLEGIIVLNIGYWGGGCRLWEGMGDETYPLARHDDGLLEVVGVYGSFHCAQIQVKLANPF 499
Query: 870 RIAQGSYFRVTL-LKATPVQVDGEPWVQAP 898
RI Q R+ L P+QVDGEPW Q P
Sbjct: 500 RIGQAHTVRLILKCSMMPMQVDGEPWAQGP 529
Score = 66.2 bits (160), Expect = 1e-10
Identities = 35/119 (29%), Positives = 58/119 (48%), Gaps = 6/119 (5%)
Query: 134 FCAVCRKVLEAPALHCEVCELHLHPDCVPFACS--DCRQCH-QDGHQDHDTHHHHWREGN 190
+C VC + + A C+ C L + C+ A C++ ++ + D HHW GN
Sbjct: 73 YCCVCAQHILQGAF-CDCCGLRVDEGCLRKADKRFQCKEIMLKNDTKVLDAMPHHWIRGN 131
Query: 191 LPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLC--SAALAPECGFGRLRSLVLPPA 247
+P + C VC++ CG L RC WC H C ++ +C FG ++L++PP+
Sbjct: 132 VPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMKNSLKNEKCDFGEFKNLIIPPS 190
Score = 36.6 bits (83), Expect = 0.11
Identities = 27/111 (24%), Positives = 47/111 (42%), Gaps = 12/111 (10%)
Query: 61 HSFRKVTL-TKPTFCHLCSDFIWGLAGFLCDVCNFMSHEKCLKHV--RIPCTSVA---PS 114
H +R L ++PT+C +C+ I L G CD C E CL+ R C + +
Sbjct: 60 HGWRDTDLFSQPTYCCVCAQHI--LQGAFCDCCGLRVDEGCLRKADKRFQCKEIMLKNDT 117
Query: 115 LVRVPVAHCFGPRGLHKRKFCAVCRKVLEAPALHCEV----CELHLHPDCV 161
V + H + + +C VC++ C+ C+ +H +C+
Sbjct: 118 KVLDAMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECM 168
>gi|157688564 diacylglycerol kinase zeta isoform 4 [Homo sapiens]
Length = 1117
Score = 238 bits (606), Expect = 3e-62
Identities = 147/373 (39%), Positives = 205/373 (54%), Gaps = 21/373 (5%)
Query: 575 PDLLHAKLPPDSCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFS 634
P ++ P PLLVFVNPKSGG +G ++ SF LNP QVFDL+ GGP L ++
Sbjct: 471 PFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYR 530
Query: 635 QVPCFRVLVCGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSG 694
+V R+L CGGDGTVGW+L L++ R + P P VAILPLGTGNDL R L WG GY+
Sbjct: 531 KVHNLRILACGGDGTVGWILSTLDQLRLK---PPPPVAILPLGTGNDLARTLNWGGGYTD 587
Query: 695 EDPFSVLLSVDEADAVLMDRWTILLDAH-EAGSAENDTADAEPPKIVQMSNYCGIGIDAE 753
E +L V+E + V +DRW + + + EAG + D + + +NY +G DA
Sbjct: 588 EPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAH 647
Query: 754 LSLDFHQAREEEPGKFTSRLHNKGVYVRVGLQK--ISHSRSLHKQIRLQVERQEVELPSI 811
++L+FH++RE P KF SR NK Y + S+ L K IR+ + ++ P I
Sbjct: 648 VTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDL-TPKI 706
Query: 812 EGL-----IFINIPSWGSGADLWGSDSDTR-FEKPRMDDGLLEVVGVTGVVHMGQVQGGL 865
+ L +F+NIP + +G WG + FE R DDG LEV+G T + + +Q G
Sbjct: 707 QDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFT-MTSLAALQVG- 764
Query: 866 RSGIRIAQGSYFRVTLLKATPVQVDGEPWVQAPGHMIISAAGPKVHMLRKAKQKPRRAGT 925
G R+ Q +T KA PVQVDGEP A + I A + M++KAK++ +
Sbjct: 765 GHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRI-ALRNQATMVQKAKRR-----S 818
Query: 926 TRDARADAAPAPE 938
+D P PE
Sbjct: 819 AAPLHSDQQPVPE 831
>gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens]
Length = 945
Score = 238 bits (606), Expect = 3e-62
Identities = 147/373 (39%), Positives = 205/373 (54%), Gaps = 21/373 (5%)
Query: 575 PDLLHAKLPPDSCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFS 634
P ++ P PLLVFVNPKSGG +G ++ SF LNP QVFDL+ GGP L ++
Sbjct: 299 PFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYR 358
Query: 635 QVPCFRVLVCGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSG 694
+V R+L CGGDGTVGW+L L++ R + P P VAILPLGTGNDL R L WG GY+
Sbjct: 359 KVHNLRILACGGDGTVGWILSTLDQLRLK---PPPPVAILPLGTGNDLARTLNWGGGYTD 415
Query: 695 EDPFSVLLSVDEADAVLMDRWTILLDAH-EAGSAENDTADAEPPKIVQMSNYCGIGIDAE 753
E +L V+E + V +DRW + + + EAG + D + + +NY +G DA
Sbjct: 416 EPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAH 475
Query: 754 LSLDFHQAREEEPGKFTSRLHNKGVYVRVGLQK--ISHSRSLHKQIRLQVERQEVELPSI 811
++L+FH++RE P KF SR NK Y + S+ L K IR+ + ++ P I
Sbjct: 476 VTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDL-TPKI 534
Query: 812 EGL-----IFINIPSWGSGADLWGSDSDTR-FEKPRMDDGLLEVVGVTGVVHMGQVQGGL 865
+ L +F+NIP + +G WG + FE R DDG LEV+G T + + +Q G
Sbjct: 535 QDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFT-MTSLAALQVG- 592
Query: 866 RSGIRIAQGSYFRVTLLKATPVQVDGEPWVQAPGHMIISAAGPKVHMLRKAKQKPRRAGT 925
G R+ Q +T KA PVQVDGEP A + I A + M++KAK++ +
Sbjct: 593 GHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRI-ALRNQATMVQKAKRR-----S 646
Query: 926 TRDARADAAPAPE 938
+D P PE
Sbjct: 647 AAPLHSDQQPVPE 659
>gi|41872507 diacylglycerol kinase zeta isoform 2 [Homo sapiens]
Length = 929
Score = 238 bits (606), Expect = 3e-62
Identities = 147/373 (39%), Positives = 205/373 (54%), Gaps = 21/373 (5%)
Query: 575 PDLLHAKLPPDSCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFS 634
P ++ P PLLVFVNPKSGG +G ++ SF LNP QVFDL+ GGP L ++
Sbjct: 283 PFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYR 342
Query: 635 QVPCFRVLVCGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSG 694
+V R+L CGGDGTVGW+L L++ R + P P VAILPLGTGNDL R L WG GY+
Sbjct: 343 KVHNLRILACGGDGTVGWILSTLDQLRLK---PPPPVAILPLGTGNDLARTLNWGGGYTD 399
Query: 695 EDPFSVLLSVDEADAVLMDRWTILLDAH-EAGSAENDTADAEPPKIVQMSNYCGIGIDAE 753
E +L V+E + V +DRW + + + EAG + D + + +NY +G DA
Sbjct: 400 EPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAH 459
Query: 754 LSLDFHQAREEEPGKFTSRLHNKGVYVRVGLQK--ISHSRSLHKQIRLQVERQEVELPSI 811
++L+FH++RE P KF SR NK Y + S+ L K IR+ + ++ P I
Sbjct: 460 VTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDL-TPKI 518
Query: 812 EGL-----IFINIPSWGSGADLWGSDSDTR-FEKPRMDDGLLEVVGVTGVVHMGQVQGGL 865
+ L +F+NIP + +G WG + FE R DDG LEV+G T + + +Q G
Sbjct: 519 QDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFT-MTSLAALQVG- 576
Query: 866 RSGIRIAQGSYFRVTLLKATPVQVDGEPWVQAPGHMIISAAGPKVHMLRKAKQKPRRAGT 925
G R+ Q +T KA PVQVDGEP A + I A + M++KAK++ +
Sbjct: 577 GHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRI-ALRNQATMVQKAKRR-----S 630
Query: 926 TRDARADAAPAPE 938
+D P PE
Sbjct: 631 AAPLHSDQQPVPE 643
>gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens]
Length = 895
Score = 238 bits (606), Expect = 3e-62
Identities = 147/373 (39%), Positives = 205/373 (54%), Gaps = 21/373 (5%)
Query: 575 PDLLHAKLPPDSCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFS 634
P ++ P PLLVFVNPKSGG +G ++ SF LNP QVFDL+ GGP L ++
Sbjct: 249 PFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYR 308
Query: 635 QVPCFRVLVCGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSG 694
+V R+L CGGDGTVGW+L L++ R + P P VAILPLGTGNDL R L WG GY+
Sbjct: 309 KVHNLRILACGGDGTVGWILSTLDQLRLK---PPPPVAILPLGTGNDLARTLNWGGGYTD 365
Query: 695 EDPFSVLLSVDEADAVLMDRWTILLDAH-EAGSAENDTADAEPPKIVQMSNYCGIGIDAE 753
E +L V+E + V +DRW + + + EAG + D + + +NY +G DA
Sbjct: 366 EPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAH 425
Query: 754 LSLDFHQAREEEPGKFTSRLHNKGVYVRVGLQK--ISHSRSLHKQIRLQVERQEVELPSI 811
++L+FH++RE P KF SR NK Y + S+ L K IR+ + ++ P I
Sbjct: 426 VTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDL-TPKI 484
Query: 812 EGL-----IFINIPSWGSGADLWGSDSDTR-FEKPRMDDGLLEVVGVTGVVHMGQVQGGL 865
+ L +F+NIP + +G WG + FE R DDG LEV+G T + + +Q G
Sbjct: 485 QDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFT-MTSLAALQVG- 542
Query: 866 RSGIRIAQGSYFRVTLLKATPVQVDGEPWVQAPGHMIISAAGPKVHMLRKAKQKPRRAGT 925
G R+ Q +T KA PVQVDGEP A + I A + M++KAK++ +
Sbjct: 543 GHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRI-ALRNQATMVQKAKRR-----S 596
Query: 926 TRDARADAAPAPE 938
+D P PE
Sbjct: 597 AAPLHSDQQPVPE 609
>gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 228 bits (580), Expect = 3e-59
Identities = 133/344 (38%), Positives = 195/344 (56%), Gaps = 38/344 (11%)
Query: 584 PDSCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLV 643
P++ PLLVFVNPKSGG +G+ +L F+ +LNP QVF+L GP GL LF VP R+LV
Sbjct: 372 PNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILV 431
Query: 644 CGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLLS 703
CGGDGTVGW+L +++ + P VA+LPLGTGNDL R LRWG GY G++ +L
Sbjct: 432 CGGDGTVGWILETIDKANLPVL---PPVAVLPLGTGNDLARCLRWGGGYEGQNLAKILKD 488
Query: 704 VDEADAVLMDRWTILLDAHEAGSAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQARE 763
++ + V MDRW++ + + + +D P +I+ +NY IG+DA ++ FH RE
Sbjct: 489 LEMSKVVHMDRWSVEVIPQQT----EEKSDPVPFQII--NNYFSIGVDASIAHRFHIMRE 542
Query: 764 EEPGKFTSRLHNKGVYVRVGLQK--ISHSRSLHKQIRLQVERQEVELP--SIEGLIFINI 819
+ P KF SR+ NK Y + S + L + + +++ + ++L S+EG+ +NI
Sbjct: 543 KYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNI 602
Query: 820 PSWGSGADLWGSD---------------------SDTRFEK---PRMDDGLLEVVGVTGV 855
PS G++LWG +D K P + D LEVVG+ G
Sbjct: 603 PSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEGA 662
Query: 856 VHMGQVQGGLRS-GIRIAQGSYFRVTLLKATPVQVDGEPWVQAP 898
+ MGQ+ L++ G R+A+ S K P+Q+DGEPW+Q P
Sbjct: 663 IEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTP 706
Score = 68.9 bits (167), Expect = 2e-11
Identities = 37/130 (28%), Positives = 56/130 (43%), Gaps = 3/130 (2%)
Query: 122 HCFGPRGLHKRKFCAVCRKV--LEAPALHCEVCELHLHPDCVPFACSDCRQCHQDGHQDH 179
H + P+ + +C +C L L C +C+ +H C A + +D
Sbjct: 206 HMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDI 265
Query: 180 DTHHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGRL 239
H W G SG RC+ C+K L G+ C WC ++ H C A+ EC G L
Sbjct: 266 GVQSHVWVRGGCESG-RCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLL 324
Query: 240 RSLVLPPACV 249
R +LPP+ +
Sbjct: 325 RDHILPPSSI 334
Score = 52.4 bits (124), Expect = 2e-06
Identities = 32/115 (27%), Positives = 51/115 (44%), Gaps = 8/115 (6%)
Query: 61 HSFRKVTLTKPTFCHLCSDFIW-GLAGFLCDVCNFMSHEKCLKHVRIPC--TSVAPSLVR 117
H +R +P +C+LC I G G C++C + H++C +PC ++ A S
Sbjct: 206 HMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKA-LPCEVSTYAKSRKD 264
Query: 118 VPVAHCFGPRGLHKRKFCAVCRKVL----EAPALHCEVCELHLHPDCVPFACSDC 168
+ V RG + C C+K + LHC C L +H DC+ +C
Sbjct: 265 IGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHEC 319
>gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 228 bits (580), Expect = 3e-59
Identities = 133/344 (38%), Positives = 195/344 (56%), Gaps = 38/344 (11%)
Query: 584 PDSCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLV 643
P++ PLLVFVNPKSGG +G+ +L F+ +LNP QVF+L GP GL LF VP R+LV
Sbjct: 372 PNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILV 431
Query: 644 CGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLLS 703
CGGDGTVGW+L +++ + P VA+LPLGTGNDL R LRWG GY G++ +L
Sbjct: 432 CGGDGTVGWILETIDKANLPVL---PPVAVLPLGTGNDLARCLRWGGGYEGQNLAKILKD 488
Query: 704 VDEADAVLMDRWTILLDAHEAGSAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQARE 763
++ + V MDRW++ + + + +D P +I+ +NY IG+DA ++ FH RE
Sbjct: 489 LEMSKVVHMDRWSVEVIPQQT----EEKSDPVPFQII--NNYFSIGVDASIAHRFHIMRE 542
Query: 764 EEPGKFTSRLHNKGVYVRVGLQK--ISHSRSLHKQIRLQVERQEVELP--SIEGLIFINI 819
+ P KF SR+ NK Y + S + L + + +++ + ++L S+EG+ +NI
Sbjct: 543 KYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNI 602
Query: 820 PSWGSGADLWGSD---------------------SDTRFEK---PRMDDGLLEVVGVTGV 855
PS G++LWG +D K P + D LEVVG+ G
Sbjct: 603 PSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEGA 662
Query: 856 VHMGQVQGGLRS-GIRIAQGSYFRVTLLKATPVQVDGEPWVQAP 898
+ MGQ+ L++ G R+A+ S K P+Q+DGEPW+Q P
Sbjct: 663 IEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTP 706
Score = 68.9 bits (167), Expect = 2e-11
Identities = 37/130 (28%), Positives = 56/130 (43%), Gaps = 3/130 (2%)
Query: 122 HCFGPRGLHKRKFCAVCRKV--LEAPALHCEVCELHLHPDCVPFACSDCRQCHQDGHQDH 179
H + P+ + +C +C L L C +C+ +H C A + +D
Sbjct: 206 HMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDI 265
Query: 180 DTHHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGRL 239
H W G SG RC+ C+K L G+ C WC ++ H C A+ EC G L
Sbjct: 266 GVQSHVWVRGGCESG-RCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLL 324
Query: 240 RSLVLPPACV 249
R +LPP+ +
Sbjct: 325 RDHILPPSSI 334
Score = 52.4 bits (124), Expect = 2e-06
Identities = 32/115 (27%), Positives = 51/115 (44%), Gaps = 8/115 (6%)
Query: 61 HSFRKVTLTKPTFCHLCSDFIW-GLAGFLCDVCNFMSHEKCLKHVRIPC--TSVAPSLVR 117
H +R +P +C+LC I G G C++C + H++C +PC ++ A S
Sbjct: 206 HMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKA-LPCEVSTYAKSRKD 264
Query: 118 VPVAHCFGPRGLHKRKFCAVCRKVL----EAPALHCEVCELHLHPDCVPFACSDC 168
+ V RG + C C+K + LHC C L +H DC+ +C
Sbjct: 265 IGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHEC 319
>gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 228 bits (580), Expect = 3e-59
Identities = 133/344 (38%), Positives = 195/344 (56%), Gaps = 38/344 (11%)
Query: 584 PDSCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLV 643
P++ PLLVFVNPKSGG +G+ +L F+ +LNP QVF+L GP GL LF VP R+LV
Sbjct: 372 PNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILV 431
Query: 644 CGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLLS 703
CGGDGTVGW+L +++ + P VA+LPLGTGNDL R LRWG GY G++ +L
Sbjct: 432 CGGDGTVGWILETIDKANLPVL---PPVAVLPLGTGNDLARCLRWGGGYEGQNLAKILKD 488
Query: 704 VDEADAVLMDRWTILLDAHEAGSAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQARE 763
++ + V MDRW++ + + + +D P +I+ +NY IG+DA ++ FH RE
Sbjct: 489 LEMSKVVHMDRWSVEVIPQQT----EEKSDPVPFQII--NNYFSIGVDASIAHRFHIMRE 542
Query: 764 EEPGKFTSRLHNKGVYVRVGLQK--ISHSRSLHKQIRLQVERQEVELP--SIEGLIFINI 819
+ P KF SR+ NK Y + S + L + + +++ + ++L S+EG+ +NI
Sbjct: 543 KYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNI 602
Query: 820 PSWGSGADLWGSD---------------------SDTRFEK---PRMDDGLLEVVGVTGV 855
PS G++LWG +D K P + D LEVVG+ G
Sbjct: 603 PSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEGA 662
Query: 856 VHMGQVQGGLRS-GIRIAQGSYFRVTLLKATPVQVDGEPWVQAP 898
+ MGQ+ L++ G R+A+ S K P+Q+DGEPW+Q P
Sbjct: 663 IEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTP 706
Score = 68.9 bits (167), Expect = 2e-11
Identities = 37/130 (28%), Positives = 56/130 (43%), Gaps = 3/130 (2%)
Query: 122 HCFGPRGLHKRKFCAVCRKV--LEAPALHCEVCELHLHPDCVPFACSDCRQCHQDGHQDH 179
H + P+ + +C +C L L C +C+ +H C A + +D
Sbjct: 206 HMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDI 265
Query: 180 DTHHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGRL 239
H W G SG RC+ C+K L G+ C WC ++ H C A+ EC G L
Sbjct: 266 GVQSHVWVRGGCESG-RCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLL 324
Query: 240 RSLVLPPACV 249
R +LPP+ +
Sbjct: 325 RDHILPPSSI 334
Score = 52.4 bits (124), Expect = 2e-06
Identities = 32/115 (27%), Positives = 51/115 (44%), Gaps = 8/115 (6%)
Query: 61 HSFRKVTLTKPTFCHLCSDFIW-GLAGFLCDVCNFMSHEKCLKHVRIPC--TSVAPSLVR 117
H +R +P +C+LC I G G C++C + H++C +PC ++ A S
Sbjct: 206 HMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKA-LPCEVSTYAKSRKD 264
Query: 118 VPVAHCFGPRGLHKRKFCAVCRKVL----EAPALHCEVCELHLHPDCVPFACSDC 168
+ V RG + C C+K + LHC C L +H DC+ +C
Sbjct: 265 IGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHEC 319
>gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 228 bits (580), Expect = 3e-59
Identities = 133/344 (38%), Positives = 195/344 (56%), Gaps = 38/344 (11%)
Query: 584 PDSCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLV 643
P++ PLLVFVNPKSGG +G+ +L F+ +LNP QVF+L GP GL LF VP R+LV
Sbjct: 372 PNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILV 431
Query: 644 CGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLLS 703
CGGDGTVGW+L +++ + P VA+LPLGTGNDL R LRWG GY G++ +L
Sbjct: 432 CGGDGTVGWILETIDKANLPVL---PPVAVLPLGTGNDLARCLRWGGGYEGQNLAKILKD 488
Query: 704 VDEADAVLMDRWTILLDAHEAGSAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQARE 763
++ + V MDRW++ + + + +D P +I+ +NY IG+DA ++ FH RE
Sbjct: 489 LEMSKVVHMDRWSVEVIPQQT----EEKSDPVPFQII--NNYFSIGVDASIAHRFHIMRE 542
Query: 764 EEPGKFTSRLHNKGVYVRVGLQK--ISHSRSLHKQIRLQVERQEVELP--SIEGLIFINI 819
+ P KF SR+ NK Y + S + L + + +++ + ++L S+EG+ +NI
Sbjct: 543 KYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNI 602
Query: 820 PSWGSGADLWGSD---------------------SDTRFEK---PRMDDGLLEVVGVTGV 855
PS G++LWG +D K P + D LEVVG+ G
Sbjct: 603 PSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEGA 662
Query: 856 VHMGQVQGGLRS-GIRIAQGSYFRVTLLKATPVQVDGEPWVQAP 898
+ MGQ+ L++ G R+A+ S K P+Q+DGEPW+Q P
Sbjct: 663 IEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTP 706
Score = 68.9 bits (167), Expect = 2e-11
Identities = 37/130 (28%), Positives = 56/130 (43%), Gaps = 3/130 (2%)
Query: 122 HCFGPRGLHKRKFCAVCRKV--LEAPALHCEVCELHLHPDCVPFACSDCRQCHQDGHQDH 179
H + P+ + +C +C L L C +C+ +H C A + +D
Sbjct: 206 HMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDI 265
Query: 180 DTHHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGRL 239
H W G SG RC+ C+K L G+ C WC ++ H C A+ EC G L
Sbjct: 266 GVQSHVWVRGGCESG-RCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLL 324
Query: 240 RSLVLPPACV 249
R +LPP+ +
Sbjct: 325 RDHILPPSSI 334
Score = 52.4 bits (124), Expect = 2e-06
Identities = 32/115 (27%), Positives = 51/115 (44%), Gaps = 8/115 (6%)
Query: 61 HSFRKVTLTKPTFCHLCSDFIW-GLAGFLCDVCNFMSHEKCLKHVRIPC--TSVAPSLVR 117
H +R +P +C+LC I G G C++C + H++C +PC ++ A S
Sbjct: 206 HMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKA-LPCEVSTYAKSRKD 264
Query: 118 VPVAHCFGPRGLHKRKFCAVCRKVL----EAPALHCEVCELHLHPDCVPFACSDC 168
+ V RG + C C+K + LHC C L +H DC+ +C
Sbjct: 265 IGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHEC 319
>gi|4758156 diacylglycerol kinase, iota [Homo sapiens]
Length = 1065
Score = 223 bits (567), Expect = 9e-58
Identities = 134/341 (39%), Positives = 193/341 (56%), Gaps = 17/341 (4%)
Query: 588 PLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLVCGGD 647
PLLVFVNPKSGG +G +L F LNP QVFDL+ GP L L+ +VP R+L CGGD
Sbjct: 376 PLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILACGGD 435
Query: 648 GTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLLSVDEA 707
GTVGW+L L+E + P+P V +LPLGTGNDL R L WG GY+ E +L V++
Sbjct: 436 GTVGWILSILDELQ---LSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDG 492
Query: 708 DAVLMDRWTILLDAH-EAGSAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQAREEEP 766
V +DRW + ++ + + E + + P V +NY +G DA ++L+FH++RE P
Sbjct: 493 TVVQLDRWNLHVERNPDLPPEELEDGVCKLPLNV-FNNYFSLGFDAHVTLEFHESREANP 551
Query: 767 GKFTSRLHNKGVYVRVGLQKI--SHSRSLHKQIRLQVERQEVELPSIEGL-----IFINI 819
KF SR NK Y SR L K +++ + ++ P I+ L +F+NI
Sbjct: 552 EKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDL-TPKIQELKFQCIVFLNI 610
Query: 820 PSWGSGADLWGSDSDTR-FEKPRMDDGLLEVVGVTGVVHMGQVQGGLRSGIRIAQGSYFR 878
P + +G WG+ D FE R DDG +EV+G T + + +Q G G R+ Q
Sbjct: 611 PRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFT-MASLAALQVG-GHGERLHQCREVM 668
Query: 879 VTLLKATPVQVDGEPWVQAPGHMIISAAGPKVHMLRKAKQK 919
+ K+ P+QVDGEP AP + IS + +M++K+K++
Sbjct: 669 LLTYKSIPMQVDGEPCRLAPAMIRISLRN-QANMVQKSKRR 708
>gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo sapiens]
Length = 766
Score = 205 bits (522), Expect = 1e-52
Identities = 127/335 (37%), Positives = 173/335 (51%), Gaps = 56/335 (16%)
Query: 584 PDSCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLV 643
P + PLLV VNPKSGG +G L + F P FRVL
Sbjct: 430 PGTHPLLVLVNPKSGGRQGERL-------------------------NFFRDTPDFRVLA 464
Query: 644 CGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLLS 703
CGGDGTVGW+L +++ + P VA+LPLGTGNDL R LRWG GY G +L
Sbjct: 465 CGGDGTVGWILDCIDKANF---AKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKD 521
Query: 704 VDEADAVLMDRWTILLDAHEAGSAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQARE 763
++++ V++DRW + + E E + D P I M+NY IG+DA ++ FH RE
Sbjct: 522 IEQSPLVMLDRWHLEVIPRE----EVENGDQVPYSI--MNNYFSIGVDASIAHRFHVMRE 575
Query: 764 EEPGKFTSRLHNKGVYVRVGLQK--ISHSRSLHKQIRLQVERQEVELPSI--EGLIFINI 819
+ P KF SR+ NK Y G + + + LH I L+ + V+L +I EG+ +NI
Sbjct: 576 KHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNI 635
Query: 820 PSWGSGADLWGSDSDTR-----------------FEKPRMDDGLLEVVGVTGVVHMGQVQ 862
PS G +LWG + R F + D LLEVVG+ G + MGQ+
Sbjct: 636 PSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIY 695
Query: 863 GGLRS-GIRIAQGSYFRVTLLKATPVQVDGEPWVQ 896
GL+S G R+AQ + + K P+QVDGEPW+Q
Sbjct: 696 TGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQ 730
Score = 55.5 bits (132), Expect = 2e-07
Identities = 33/131 (25%), Positives = 51/131 (38%), Gaps = 7/131 (5%)
Query: 122 HCFGPRGLHKRKFCAVCRKVL---EAPALHCEVCELHLHPDCVPFACSDCRQCHQDGHQD 178
H + + K +C C +L L C C+ +H CV C + + +
Sbjct: 272 HAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKAKRS 331
Query: 179 HDTHHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGR 238
+ H W EGN S +C+ C K+ + C WC + H C L+ C G
Sbjct: 332 GEVMQHAWVEGN--SSVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCE--LSTLCDGGE 387
Query: 239 LRSLVLPPACV 249
LR +L P +
Sbjct: 388 LRDHILLPTSI 398
Score = 37.7 bits (86), Expect = 0.051
Identities = 27/107 (25%), Positives = 39/107 (36%), Gaps = 8/107 (7%)
Query: 61 HSFRKVTLTKPTFCHLCSDFIWGL--AGFLCDVCNFMSHEKCLKHVRIPCTSVAPSLVRV 118
H++ KPT+C+ C + G+ G C C + HE+C+ C R
Sbjct: 272 HAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKAKRS 331
Query: 119 -PVAHCFGPRGLHKRKFCAVCRKVLE----APALHCEVCELHLHPDC 160
V G K C C K ++ A HC C + H C
Sbjct: 332 GEVMQHAWVEGNSSVK-CDRCHKSIKCYQSVTARHCVWCRMTFHRKC 377
>gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo
sapiens]
Length = 1170
Score = 132 bits (332), Expect = 2e-30
Identities = 78/180 (43%), Positives = 102/180 (56%), Gaps = 13/180 (7%)
Query: 584 PDSC--PLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRV 641
P SC PLLVFVN KSG +G L F++LLNP QVFDL NGGP GL LF + FR+
Sbjct: 271 PPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRI 330
Query: 642 LVCGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPF-SV 700
LVCGGDG+VGWVL ++ C + +LPLGTGNDL RVL WG+ + +
Sbjct: 331 LVCGGDGSVGWVLSEIDSLNLHKQC---QLGVLPLGTGNDLARVLGWGSACDDDTQLPQI 387
Query: 701 LLSVDEADAVLMDRWTILLDAHEA-----GSAENDTADAEPPKIVQMSNYCGIGIDAELS 755
L ++ A ++DRW+++ A+EA S+ T D VQ + + A LS
Sbjct: 388 LEKLERASTKMLDRWSVM--AYEAKLPRQASSSTVTEDFSEDSEVQQILFYEDSVAAHLS 445
Score = 119 bits (297), Expect = 2e-26
Identities = 69/183 (37%), Positives = 109/183 (59%), Gaps = 6/183 (3%)
Query: 726 SAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQAREEEPGKFTSRLHNKGVYVRVGLQ 785
++E +T + K V M+NY GIG+DA++SLDF+ R+E P K SR N Y +G +
Sbjct: 705 NSEPETLEYYTEKCV-MNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTK 763
Query: 786 KISHS--RSLHKQIRLQVERQEVELPSIEGLIFINIPSWGSGADLW-GSDSDTRFEKPRM 842
++ H ++L +++ L+ + + + LPS++G+ +NIPS+ G + W G+ D F P
Sbjct: 764 ELLHRTYKNLEQKVLLECDGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSF 823
Query: 843 DDGLLEVVGVTGVVHMGQVQGGLRSGIRIAQGSYFRVTLL--KATPVQVDGEPWVQAPGH 900
DD +LEVV V G + M + RIAQ ++++L + PVQVDGE WVQ PG+
Sbjct: 824 DDKILEVVAVFGSMQMAVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGY 883
Query: 901 MII 903
+ I
Sbjct: 884 IRI 886
Score = 87.4 bits (215), Expect = 6e-17
Identities = 49/136 (36%), Positives = 65/136 (47%), Gaps = 11/136 (8%)
Query: 134 FCAVCRKVLEAPALH---CEVCELHLHPDCVPFACSDCR-----QCHQDGHQDHD--THH 183
+C VCR+ L H CEVC+ H C A ++C+ +D +D D
Sbjct: 132 YCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADGIAMP 191
Query: 184 HHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGRLRSLV 243
H W EGNLP A+C VC KTCGS L RC WC H+ C +L +C G + V
Sbjct: 192 HQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLCKVSV 251
Query: 244 LPPACVRLLPG-GFSK 258
+PP + + GF K
Sbjct: 252 IPPTALNSIDSDGFWK 267
Score = 44.7 bits (104), Expect = 4e-04
Identities = 28/123 (22%), Positives = 51/123 (41%), Gaps = 15/123 (12%)
Query: 61 HSFRKVTLTKPTFCHLCSDFIWGLA--GFLCDVCNFMSHEKCLKHVRIPC-----TSVAP 113
H++ + +PT+C++C + + G+ G C+VC F +H++C C S+
Sbjct: 120 HNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGK 179
Query: 114 SLVR----VPVAHCFGPRGLHKRKFCAVCRK----VLEAPALHCEVCELHLHPDCVPFAC 165
++ + + H + L C VC K VL C C+ +H C
Sbjct: 180 DIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLL 239
Query: 166 SDC 168
+ C
Sbjct: 240 TKC 242
Score = 35.4 bits (80), Expect = 0.25
Identities = 19/65 (29%), Positives = 28/65 (43%), Gaps = 1/65 (1%)
Query: 178 DHDTHHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFG 237
DH + H+W + C VCR+ S G+ CE C +AH C+ C +
Sbjct: 114 DHFSGMHNWYACSHARPTYCNVCREAL-SGVTSHGLSCEVCKFKAHKRCAVRATNNCKWT 172
Query: 238 RLRSL 242
L S+
Sbjct: 173 TLASI 177
>gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo
sapiens]
Length = 1214
Score = 132 bits (332), Expect = 2e-30
Identities = 78/180 (43%), Positives = 102/180 (56%), Gaps = 13/180 (7%)
Query: 584 PDSC--PLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRV 641
P SC PLLVFVN KSG +G L F++LLNP QVFDL NGGP GL LF + FR+
Sbjct: 315 PPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRI 374
Query: 642 LVCGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPF-SV 700
LVCGGDG+VGWVL ++ C + +LPLGTGNDL RVL WG+ + +
Sbjct: 375 LVCGGDGSVGWVLSEIDSLNLHKQC---QLGVLPLGTGNDLARVLGWGSACDDDTQLPQI 431
Query: 701 LLSVDEADAVLMDRWTILLDAHEA-----GSAENDTADAEPPKIVQMSNYCGIGIDAELS 755
L ++ A ++DRW+++ A+EA S+ T D VQ + + A LS
Sbjct: 432 LEKLERASTKMLDRWSVM--AYEAKLPRQASSSTVTEDFSEDSEVQQILFYEDSVAAHLS 489
Score = 119 bits (297), Expect = 2e-26
Identities = 69/183 (37%), Positives = 109/183 (59%), Gaps = 6/183 (3%)
Query: 726 SAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQAREEEPGKFTSRLHNKGVYVRVGLQ 785
++E +T + K V M+NY GIG+DA++SLDF+ R+E P K SR N Y +G +
Sbjct: 749 NSEPETLEYYTEKCV-MNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTK 807
Query: 786 KISHS--RSLHKQIRLQVERQEVELPSIEGLIFINIPSWGSGADLW-GSDSDTRFEKPRM 842
++ H ++L +++ L+ + + + LPS++G+ +NIPS+ G + W G+ D F P
Sbjct: 808 ELLHRTYKNLEQKVLLECDGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSF 867
Query: 843 DDGLLEVVGVTGVVHMGQVQGGLRSGIRIAQGSYFRVTLL--KATPVQVDGEPWVQAPGH 900
DD +LEVV V G + M + RIAQ ++++L + PVQVDGE WVQ PG+
Sbjct: 868 DDKILEVVAVFGSMQMAVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGY 927
Query: 901 MII 903
+ I
Sbjct: 928 IRI 930
Score = 87.4 bits (215), Expect = 6e-17
Identities = 49/136 (36%), Positives = 65/136 (47%), Gaps = 11/136 (8%)
Query: 134 FCAVCRKVLEAPALH---CEVCELHLHPDCVPFACSDCR-----QCHQDGHQDHD--THH 183
+C VCR+ L H CEVC+ H C A ++C+ +D +D D
Sbjct: 176 YCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADGIAMP 235
Query: 184 HHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGRLRSLV 243
H W EGNLP A+C VC KTCGS L RC WC H+ C +L +C G + V
Sbjct: 236 HQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLCKVSV 295
Query: 244 LPPACVRLLPG-GFSK 258
+PP + + GF K
Sbjct: 296 IPPTALNSIDSDGFWK 311
Score = 44.7 bits (104), Expect = 4e-04
Identities = 28/123 (22%), Positives = 51/123 (41%), Gaps = 15/123 (12%)
Query: 61 HSFRKVTLTKPTFCHLCSDFIWGLA--GFLCDVCNFMSHEKCLKHVRIPC-----TSVAP 113
H++ + +PT+C++C + + G+ G C+VC F +H++C C S+
Sbjct: 164 HNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGK 223
Query: 114 SLVR----VPVAHCFGPRGLHKRKFCAVCRK----VLEAPALHCEVCELHLHPDCVPFAC 165
++ + + H + L C VC K VL C C+ +H C
Sbjct: 224 DIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLL 283
Query: 166 SDC 168
+ C
Sbjct: 284 TKC 286
Score = 35.4 bits (80), Expect = 0.25
Identities = 19/65 (29%), Positives = 28/65 (43%), Gaps = 1/65 (1%)
Query: 178 DHDTHHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFG 237
DH + H+W + C VCR+ S G+ CE C +AH C+ C +
Sbjct: 158 DHFSGMHNWYACSHARPTYCNVCREAL-SGVTSHGLSCEVCKFKAHKRCAVRATNNCKWT 216
Query: 238 RLRSL 242
L S+
Sbjct: 217 TLASI 221
>gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens]
Length = 1164
Score = 131 bits (330), Expect = 3e-30
Identities = 66/132 (50%), Positives = 85/132 (64%), Gaps = 4/132 (3%)
Query: 588 PLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLVCGGD 647
PLLVFVN KSG +G L F++LLNP QVFDL NGGP GL LF + FR+LVCGGD
Sbjct: 332 PLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGGD 391
Query: 648 GTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPF-SVLLSVDE 706
G+VGWVL +++ C + +LPLGTGNDL RVL WG Y + +L ++
Sbjct: 392 GSVGWVLSEIDKLNLNKQC---QLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLER 448
Query: 707 ADAVLMDRWTIL 718
A ++DRW+I+
Sbjct: 449 ASTKMLDRWSIM 460
Score = 112 bits (281), Expect = 1e-24
Identities = 66/175 (37%), Positives = 101/175 (57%), Gaps = 6/175 (3%)
Query: 730 DTADAEPPKIVQMSNYCGIGIDAELSLDFHQAREEEPGKFTSRLHNKGVYVRVGLQKISH 789
D+ D K V M+NY GIG+DA++SL+F+ REE P K SR N Y +G +++
Sbjct: 760 DSVDGYSEKCV-MNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQ 818
Query: 790 S--RSLHKQIRLQVERQEVELPSIEGLIFINIPSWGSGADLW-GSDSDTRFEKPRMDDGL 846
++L ++++L+ + Q + LPS++G+ +NIPS+ G + W G+ D F P DD +
Sbjct: 819 RSYKNLEQRVQLECDGQYIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKI 878
Query: 847 LEVVGVTGVVHMGQVQGGLRSGIRIAQGSYFRVTLL--KATPVQVDGEPWVQAPG 899
LEVV + + M + RIAQ ++T+ + PVQVDGE WVQ PG
Sbjct: 879 LEVVAIFDSMQMAVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPG 933
Score = 85.9 bits (211), Expect = 2e-16
Identities = 45/123 (36%), Positives = 59/123 (47%), Gaps = 10/123 (8%)
Query: 134 FCAVCRKVLEAPALH---CEVCELHLHPDCVPFACSDCR-----QCHQDGHQDHD--THH 183
FC VCR+ L H CEVC+ H C A ++C+ +D +D D
Sbjct: 188 FCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDGVAMP 247
Query: 184 HHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGRLRSLV 243
H W EGNLP A+C VC KTCGS L +C WC H+ C P C G+ + +
Sbjct: 248 HQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPLGQCKVSI 307
Query: 244 LPP 246
+PP
Sbjct: 308 IPP 310
Score = 45.8 bits (107), Expect = 2e-04
Identities = 30/115 (26%), Positives = 50/115 (43%), Gaps = 15/115 (13%)
Query: 61 HSFRKVTLTKPTFCHLCSDFIWGLA--GFLCDVCNFMSHEKCLKHVRIPC-----TSVAP 113
H++ + +PTFC++C + + G+ G C+VC F +H++C C S+
Sbjct: 176 HNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGK 235
Query: 114 SLVR----VPVAHCFGPRGLHKRKFCAVCRK----VLEAPALHCEVCELHLHPDC 160
++ V + H + L CAVC K VL C C+ +H C
Sbjct: 236 DIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTAC 290
>gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens]
Length = 1220
Score = 131 bits (330), Expect = 3e-30
Identities = 66/132 (50%), Positives = 85/132 (64%), Gaps = 4/132 (3%)
Query: 588 PLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLVCGGD 647
PLLVFVN KSG +G L F++LLNP QVFDL NGGP GL LF + FR+LVCGGD
Sbjct: 332 PLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGGD 391
Query: 648 GTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPF-SVLLSVDE 706
G+VGWVL +++ C + +LPLGTGNDL RVL WG Y + +L ++
Sbjct: 392 GSVGWVLSEIDKLNLNKQC---QLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLER 448
Query: 707 ADAVLMDRWTIL 718
A ++DRW+I+
Sbjct: 449 ASTKMLDRWSIM 460
Score = 112 bits (281), Expect = 1e-24
Identities = 66/175 (37%), Positives = 101/175 (57%), Gaps = 6/175 (3%)
Query: 730 DTADAEPPKIVQMSNYCGIGIDAELSLDFHQAREEEPGKFTSRLHNKGVYVRVGLQKISH 789
D+ D K V M+NY GIG+DA++SL+F+ REE P K SR N Y +G +++
Sbjct: 760 DSVDGYSEKCV-MNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQ 818
Query: 790 S--RSLHKQIRLQVERQEVELPSIEGLIFINIPSWGSGADLW-GSDSDTRFEKPRMDDGL 846
++L ++++L+ + Q + LPS++G+ +NIPS+ G + W G+ D F P DD +
Sbjct: 819 RSYKNLEQRVQLECDGQYIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKI 878
Query: 847 LEVVGVTGVVHMGQVQGGLRSGIRIAQGSYFRVTLL--KATPVQVDGEPWVQAPG 899
LEVV + + M + RIAQ ++T+ + PVQVDGE WVQ PG
Sbjct: 879 LEVVAIFDSMQMAVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPG 933
Score = 85.9 bits (211), Expect = 2e-16
Identities = 45/123 (36%), Positives = 59/123 (47%), Gaps = 10/123 (8%)
Query: 134 FCAVCRKVLEAPALH---CEVCELHLHPDCVPFACSDCR-----QCHQDGHQDHD--THH 183
FC VCR+ L H CEVC+ H C A ++C+ +D +D D
Sbjct: 188 FCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDGVAMP 247
Query: 184 HHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGRLRSLV 243
H W EGNLP A+C VC KTCGS L +C WC H+ C P C G+ + +
Sbjct: 248 HQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPLGQCKVSI 307
Query: 244 LPP 246
+PP
Sbjct: 308 IPP 310
Score = 45.8 bits (107), Expect = 2e-04
Identities = 30/115 (26%), Positives = 50/115 (43%), Gaps = 15/115 (13%)
Query: 61 HSFRKVTLTKPTFCHLCSDFIWGLA--GFLCDVCNFMSHEKCLKHVRIPC-----TSVAP 113
H++ + +PTFC++C + + G+ G C+VC F +H++C C S+
Sbjct: 176 HNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGK 235
Query: 114 SLVR----VPVAHCFGPRGLHKRKFCAVCRK----VLEAPALHCEVCELHLHPDC 160
++ V + H + L CAVC K VL C C+ +H C
Sbjct: 236 DIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTAC 290
>gi|62000702 diacylglycerol kinase kappa [Homo sapiens]
Length = 1271
Score = 130 bits (328), Expect = 4e-30
Identities = 63/135 (46%), Positives = 88/135 (65%), Gaps = 4/135 (2%)
Query: 586 SCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLVCG 645
SCPLL+F+N KSG +G L F++ LNP QVFDL GGP GL +F FR+LVCG
Sbjct: 489 SCPLLIFINSKSGDHQGIVFLRKFKQYLNPSQVFDLLKGGPEAGLSMFKNFARFRILVCG 548
Query: 646 GDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYS-GEDPFSVLLSV 704
GDG+V WVL ++ C +A++PLGTGNDL RVL WGA ++ + P +L V
Sbjct: 549 GDGSVSWVLSLIDAFGLHEKC---QLAVIPLGTGNDLARVLGWGAFWNKSKSPLDILNRV 605
Query: 705 DEADAVLMDRWTILL 719
++A ++DRW++++
Sbjct: 606 EQASVRILDRWSVMI 620
Score = 124 bits (311), Expect = 4e-28
Identities = 72/205 (35%), Positives = 116/205 (56%), Gaps = 6/205 (2%)
Query: 742 MSNYCGIGIDAELSLDFHQAREEEPGKFTSRLHNKGVYVRVGLQKISHS--RSLHKQIRL 799
M+NY GIG+DA++SLDF+ R+E PG++ SRL NK Y +G +++ R L +++ L
Sbjct: 858 MNNYFGIGLDAKISLDFNTRRDEHPGQYNSRLKNKMWYGLLGTKELLQRSYRKLEERVHL 917
Query: 800 QVERQEVELPSIEGLIFINIPSWGSGADLWGSD-SDTRFEKPRMDDGLLEVVGVTGVVHM 858
+ + + + LP+++G++ +NI S+ G + WGS+ + T +E P +DDG LEVV + G V M
Sbjct: 918 ECDGETISLPNLQGIVVLNITSYAGGINFWGSNTATTEYEAPAIDDGKLEVVAIFGSVQM 977
Query: 859 GQVQGGLRSGIRIAQGSYFRVTL--LKATPVQVDGEPWVQAPGHMIISAAGPKVHMLR-K 915
+ RIAQ +T+ + PVQVDGE W+Q PG + I + R +
Sbjct: 978 AMSRIINLHHHRIAQCHEVMITIDGEEGIPVQVDGEAWIQRPGLIKIRYKNAAQMLTRDR 1037
Query: 916 AKQKPRRAGTTRDARADAAPAPESD 940
+ + + AAP P+ D
Sbjct: 1038 DFENSMKMWEYKHTEIQAAPQPQLD 1062
Score = 87.4 bits (215), Expect = 6e-17
Identities = 51/154 (33%), Positives = 70/154 (45%), Gaps = 12/154 (7%)
Query: 105 RIPCTSVAPSLVRVPVAHCFGPRGLHKRKFCAVCRKVLEA---PALHCEVCELHLHPDCV 161
+IP P LV + HC+ H+ + C VCR+ + A A+ CEVC++ H C
Sbjct: 314 KIPAAENNPFLVGM---HCWYSSYSHRTQHCNVCRESIPALSRDAIICEVCKVKSHRLCA 370
Query: 162 PFACSDCRQCHQDGHQD------HDTHHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRC 215
A DC+ D H W EGN+P ++C VC ++CGS L RC
Sbjct: 371 LRASKDCKWNTLSITDDLLLPADEVNMPHQWVEGNMPVSSQCAVCHESCGSYQRLQDFRC 430
Query: 216 EWCGVQAHSLCSAALAPECGFGRLRSLVLPPACV 249
WC H C + EC F RS V+PP +
Sbjct: 431 LWCNSTVHDDCRRRFSKECCFRSHRSSVIPPTAL 464
Score = 30.4 bits (67), Expect = 8.1
Identities = 24/101 (23%), Positives = 37/101 (36%), Gaps = 14/101 (13%)
Query: 74 CHLCSDFIWGLA--GFLCDVCNFMSHEKCLKHVRIPC----TSVAPSLV----RVPVAHC 123
C++C + I L+ +C+VC SH C C S+ L+ V + H
Sbjct: 341 CNVCRESIPALSRDAIICEVCKVKSHRLCALRASKDCKWNTLSITDDLLLPADEVNMPHQ 400
Query: 124 FGPRGLHKRKFCAVCRK----VLEAPALHCEVCELHLHPDC 160
+ + CAVC + C C +H DC
Sbjct: 401 WVEGNMPVSSQCAVCHESCGSYQRLQDFRCLWCNSTVHDDC 441
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 68.9 bits (167), Expect = 2e-11
Identities = 47/157 (29%), Positives = 64/157 (40%), Gaps = 26/157 (16%)
Query: 38 GPGPGPGPE-------RAGVRAPGPAAAPGHSFRKVTLTKPTFCHLCSDFIWGLA--GFL 88
GP P G E + +R H F +PTFC C+DFIWG GF
Sbjct: 7 GPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQ 66
Query: 89 CDVCNFMSHEKCLKHVRIPCTSVAPSLVRVPVAHCFGPRGLHKRK--------FCAVCRK 140
C VC F+ H++C + V C P + P + PR HK K FC C
Sbjct: 67 CQVCCFVVHKRCHEFVTFSC----PGADKGPASD--DPRSKHKFKIHTYSSPTFCDHCGS 120
Query: 141 VLEA---PALHCEVCELHLHPDCVPFACSDCRQCHQD 174
+L + C+ C +++H CV S C H +
Sbjct: 121 LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTE 157
Score = 37.4 bits (85), Expect = 0.066
Identities = 25/117 (21%), Positives = 40/117 (34%), Gaps = 4/117 (3%)
Query: 122 HCFGPRGLHKRKFCAVCRKVLEA---PALHCEVCELHLHPDCVPFACSDCRQCHQDGHQD 178
H F R + FC+ C + C+VC +H C F C + D
Sbjct: 37 HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASD 96
Query: 179 HDTHHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECG 235
H ++ S C+ C + G++C+ C + H C + CG
Sbjct: 97 DPRSKHKFKIHTYSSPTFCDHCGSLLYGL-IHQGMKCDTCMMNVHKRCVMNVPSLCG 152
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 68.9 bits (167), Expect = 2e-11
Identities = 47/157 (29%), Positives = 64/157 (40%), Gaps = 26/157 (16%)
Query: 38 GPGPGPGPE-------RAGVRAPGPAAAPGHSFRKVTLTKPTFCHLCSDFIWGLA--GFL 88
GP P G E + +R H F +PTFC C+DFIWG GF
Sbjct: 7 GPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQ 66
Query: 89 CDVCNFMSHEKCLKHVRIPCTSVAPSLVRVPVAHCFGPRGLHKRK--------FCAVCRK 140
C VC F+ H++C + V C P + P + PR HK K FC C
Sbjct: 67 CQVCCFVVHKRCHEFVTFSC----PGADKGPASD--DPRSKHKFKIHTYSSPTFCDHCGS 120
Query: 141 VLEA---PALHCEVCELHLHPDCVPFACSDCRQCHQD 174
+L + C+ C +++H CV S C H +
Sbjct: 121 LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTE 157
Score = 37.4 bits (85), Expect = 0.066
Identities = 25/117 (21%), Positives = 40/117 (34%), Gaps = 4/117 (3%)
Query: 122 HCFGPRGLHKRKFCAVCRKVLEA---PALHCEVCELHLHPDCVPFACSDCRQCHQDGHQD 178
H F R + FC+ C + C+VC +H C F C + D
Sbjct: 37 HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASD 96
Query: 179 HDTHHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECG 235
H ++ S C+ C + G++C+ C + H C + CG
Sbjct: 97 DPRSKHKFKIHTYSSPTFCDHCGSLLYGL-IHQGMKCDTCMMNVHKRCVMNVPSLCG 152
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 65.9 bits (159), Expect = 2e-10
Identities = 44/154 (28%), Positives = 58/154 (37%), Gaps = 17/154 (11%)
Query: 38 GPGPGPGPERAG----------VRAPGPAAAPGHSFRKVTLTKPTFCHLCSDFIWGLA-- 85
G GPG G G +R H F +PTFC C+DFIWG+
Sbjct: 3 GLGPGVGDSEGGPRPLFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGKQ 62
Query: 86 GFLCDVCNFMSHEKCLKHVRIPCTSV--APSLVRVPVAHCFGPRGLHKRKFCAVCRKVLE 143
G C VC+F+ H +C + V C P H F FC C +L
Sbjct: 63 GLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSLLY 122
Query: 144 A---PALHCEVCELHLHPDCVPFACSDCRQCHQD 174
+ C CE+++H CV S C H +
Sbjct: 123 GLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTE 156
Score = 44.3 bits (103), Expect = 5e-04
Identities = 28/118 (23%), Positives = 45/118 (38%), Gaps = 4/118 (3%)
Query: 121 AHCFGPRGLHKRKFCAVCRKVLEA---PALHCEVCELHLHPDCVPFACSDCRQCHQDGHQ 177
+H F R + FC+ C + L C+VC +H C F +C +
Sbjct: 35 SHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQT 94
Query: 178 DHDTHHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECG 235
D + H +R + S C+ C V G++C C + H C ++ CG
Sbjct: 95 DDPRNKHKFRLHSYSSPTFCDHCGSLLYGL-VHQGMKCSCCEMNVHRRCVRSVPSLCG 151
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 65.5 bits (158), Expect = 2e-10
Identities = 41/127 (32%), Positives = 56/127 (44%), Gaps = 19/127 (14%)
Query: 61 HSFRKVTLTKPTFCHLCSDFIWGLA--GFLCDVCNFMSHEKCLKHVRIPCTSVAPSLVRV 118
H F +PTFC C+DFIWG GF C VC F+ H++C + V C P +
Sbjct: 37 HKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC----PGADKG 92
Query: 119 PVAHCFGPRGLHKRK--------FCAVCRKVLEA---PALHCEVCELHLHPDCVPFACSD 167
P PR HK K FC C +L + C+ C++++H CV S
Sbjct: 93 PDTD--DPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSL 150
Query: 168 CRQCHQD 174
C H +
Sbjct: 151 CGMDHTE 157
Score = 37.0 bits (84), Expect = 0.087
Identities = 25/117 (21%), Positives = 40/117 (34%), Gaps = 4/117 (3%)
Query: 122 HCFGPRGLHKRKFCAVCRKVLEA---PALHCEVCELHLHPDCVPFACSDCRQCHQDGHQD 178
H F R + FC+ C + C+VC +H C F C + D
Sbjct: 37 HKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTD 96
Query: 179 HDTHHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECG 235
H ++ S C+ C + G++C+ C + H C + CG
Sbjct: 97 DPRSKHKFKIHTYGSPTFCDHCGSLLYGL-IHQGMKCDTCDMNVHKQCVINVPSLCG 152
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 64.3 bits (155), Expect = 5e-10
Identities = 36/124 (29%), Positives = 53/124 (42%), Gaps = 15/124 (12%)
Query: 60 GHSFRKVTLTKPTFCHLCSDFIWGL---AGFLCDVCNFMSHEKCLKHVRIPCT------- 109
GH F L +PT+C C DFIWG+ G+ C VC + H++C + + C
Sbjct: 169 GHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQET 228
Query: 110 --SVAPSLVRVPVAHCFGPRGLHKRKFCAVCRKVLEA---PALHCEVCELHLHPDCVPFA 164
V V + H FG FC C +L L C+VC++++H C
Sbjct: 229 PDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNV 288
Query: 165 CSDC 168
+C
Sbjct: 289 APNC 292
Score = 40.0 bits (92), Expect = 0.010
Identities = 24/77 (31%), Positives = 30/77 (38%), Gaps = 9/77 (11%)
Query: 44 GPERAGVRAPGPAAAPGHSFRKVTLTKPTFCHLCSDFIWGLA--GFLCDVCNFMSHEKCL 101
G +R V P H F PTFC C +WGL G C VC H +C
Sbjct: 233 GSQRFSVNMP-------HKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCE 285
Query: 102 KHVRIPCTSVAPSLVRV 118
+V C A + +V
Sbjct: 286 TNVAPNCGVDARGIAKV 302
Score = 35.4 bits (80), Expect = 0.25
Identities = 29/125 (23%), Positives = 45/125 (36%), Gaps = 12/125 (9%)
Query: 122 HCFGPRGLHKRKFCAVCRK----VLEAPALHCEVCELHLHPDCVPFACSDCRQCH----- 172
H F L + +C+ CR V+ C+VC +H C + C
Sbjct: 170 HKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETP 229
Query: 173 -QDGHQDHDTHH-HHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAAL 230
Q G Q + H + N C+ C + G++C+ C + H C +
Sbjct: 230 DQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGL-LRQGLQCKVCKMNVHRRCETNV 288
Query: 231 APECG 235
AP CG
Sbjct: 289 APNCG 293
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 61.6 bits (148), Expect = 3e-09
Identities = 33/125 (26%), Positives = 53/125 (42%), Gaps = 16/125 (12%)
Query: 60 GHSFRKVTLTKPTFCHLCSDFIWGL---AGFLCDVCNFMSHEKCLKHVRIPCT------- 109
GH F L +PT+C C +FIWG+ G+ C VC + H++C + CT
Sbjct: 171 GHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNINK 230
Query: 110 ---SVAPSLVRVPVAHCFGPRGLHKRKFCAVCRKVL---EAPALHCEVCELHLHPDCVPF 163
+A + + H F FC C +L L C++C++++H C
Sbjct: 231 VDSKIAEQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQAN 290
Query: 164 ACSDC 168
+C
Sbjct: 291 VAPNC 295
Score = 38.5 bits (88), Expect = 0.030
Identities = 40/151 (26%), Positives = 59/151 (39%), Gaps = 16/151 (10%)
Query: 122 HCFGPRGLHKRKFCAVCRK----VLEAPALHCEVCELHLHPDCVPFACSDCRQCHQDGHQ 177
H F L + +C+ CR+ V C+VC +H C + C C Q+
Sbjct: 172 HKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACT-C-QNNIN 229
Query: 178 DHDTHHHHWREG-NLPS-----GARCEVCRKTCGS---SDVLAGVRCEWCGVQAHSLCSA 228
D+ R G N+P + CGS + G++C+ C + H C A
Sbjct: 230 KVDSKIAEQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQA 289
Query: 229 ALAPECGFGRLRSLVLPPACVRLLPGGFSKT 259
+AP CG + L A + L PG S T
Sbjct: 290 NVAPNCGVNAV-ELAKTLAGMGLQPGNISPT 319
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 61.2 bits (147), Expect = 4e-09
Identities = 34/114 (29%), Positives = 49/114 (42%), Gaps = 14/114 (12%)
Query: 61 HSFRKVTLTKPTFCHLCSDFIWGL--AGFLCDVCNFMSHEKCLKHVRIPCTSVA------ 112
H F +PTFC +C +F+WGL G+ C CN H+KC+ V CT A
Sbjct: 160 HEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRET 219
Query: 113 ---PSLVRVPVAHCFGPRGLHKRKFCAVCRKVLEAPA---LHCEVCELHLHPDC 160
++ + H F FC C +L A L C+ C +++H C
Sbjct: 220 MFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRC 273
Score = 43.5 bits (101), Expect = 0.001
Identities = 19/50 (38%), Positives = 22/50 (44%), Gaps = 2/50 (4%)
Query: 61 HSFRKVTLTKPTFCHLCSDFIWGLA--GFLCDVCNFMSHEKCLKHVRIPC 108
H F+ PTFC C +WGLA G CD C H +C V C
Sbjct: 232 HRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLC 281
Score = 38.9 bits (89), Expect = 0.023
Identities = 26/115 (22%), Positives = 41/115 (35%), Gaps = 11/115 (9%)
Query: 134 FCAVCRKV---LEAPALHCEVCELHLHPDCVPFACSDCRQCHQDGHQD--HDTHH----- 183
FC+VC + L C C +H C+ + C + + H
Sbjct: 172 FCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMP 231
Query: 184 HHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGR 238
H ++ N S CE C G++C+ CG+ H C +A CG +
Sbjct: 232 HRFKVYNYKSPTFCEHCGTLLWGL-ARQGLKCDACGMNVHHRCQTKVANLCGINQ 285
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 60.5 bits (145), Expect = 7e-09
Identities = 34/114 (29%), Positives = 48/114 (42%), Gaps = 14/114 (12%)
Query: 61 HSFRKVTLTKPTFCHLCSDFIWGL--AGFLCDVCNFMSHEKCLKHVRIPCTSVAPS---- 114
H F +PTFC +C DF+WGL G+ C CN H+KC+ + CT A +
Sbjct: 159 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDT 218
Query: 115 -----LVRVPVAHCFGPRGLHKRKFCAVCRKV---LEAPALHCEVCELHLHPDC 160
+ + H F FC C + L L CE C +++H C
Sbjct: 219 IFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKC 272
Score = 38.1 bits (87), Expect = 0.039
Identities = 27/115 (23%), Positives = 41/115 (35%), Gaps = 11/115 (9%)
Query: 134 FCAVCRKV---LEAPALHCEVCELHLHPDCVPFACSDC-------RQCHQDGHQDHDTHH 183
FC+VC+ L C C +H C+ C R + +
Sbjct: 171 FCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMP 230
Query: 184 HHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGR 238
H ++ N S C+ C V G++CE CG+ H C +A CG +
Sbjct: 231 HRFKVHNYMSPTFCDHCGSLLWGL-VKQGLKCEDCGMNVHHKCREKVANLCGINQ 284
>gi|31377782 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 60.5 bits (145), Expect = 7e-09
Identities = 34/114 (29%), Positives = 48/114 (42%), Gaps = 14/114 (12%)
Query: 61 HSFRKVTLTKPTFCHLCSDFIWGL--AGFLCDVCNFMSHEKCLKHVRIPCTSVAPS---- 114
H F +PTFC +C DF+WGL G+ C CN H+KC+ + CT A +
Sbjct: 159 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDT 218
Query: 115 -----LVRVPVAHCFGPRGLHKRKFCAVCRKV---LEAPALHCEVCELHLHPDC 160
+ + H F FC C + L L CE C +++H C
Sbjct: 219 IFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKC 272
Score = 38.1 bits (87), Expect = 0.039
Identities = 27/115 (23%), Positives = 41/115 (35%), Gaps = 11/115 (9%)
Query: 134 FCAVCRKV---LEAPALHCEVCELHLHPDCVPFACSDC-------RQCHQDGHQDHDTHH 183
FC+VC+ L C C +H C+ C R + +
Sbjct: 171 FCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMP 230
Query: 184 HHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGR 238
H ++ N S C+ C V G++CE CG+ H C +A CG +
Sbjct: 231 HRFKVHNYMSPTFCDHCGSLLWGL-VKQGLKCEDCGMNVHHKCREKVANLCGINQ 284
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.432
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,931,042
Number of Sequences: 37866
Number of extensions: 2466446
Number of successful extensions: 15217
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 136
Number of HSP's successfully gapped in prelim test: 338
Number of HSP's that attempted gapping in prelim test: 12791
Number of HSP's gapped (non-prelim): 2345
length of query: 942
length of database: 18,247,518
effective HSP length: 112
effective length of query: 830
effective length of database: 14,006,526
effective search space: 11625416580
effective search space used: 11625416580
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.