Guide to the Human Genome
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Search of human proteins with 40353727

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40353727 synaptopodin isoform A [Homo sapiens]
         (903 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40353727 synaptopodin isoform A [Homo sapiens]                    1828   0.0  
gi|158303333 synaptopodin isoform B [Homo sapiens]                   1349   0.0  
gi|166706868 synaptopodin 2-like isoform a [Homo sapiens]             147   6e-35
gi|50301232 synaptopodin 2-like isoform b [Homo sapiens]              147   6e-35
gi|193083183 synaptopodin 2 isoform a [Homo sapiens]                  119   1e-26
gi|163965366 nascent polypeptide-associated complex alpha subuni...   115   2e-25
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...   107   5e-23
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...   104   3e-22
gi|193083191 synaptopodin 2 isoform c [Homo sapiens]                  101   3e-21
gi|193083185 synaptopodin 2 isoform b [Homo sapiens]                  101   4e-21
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    99   2e-20
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    95   3e-19
gi|150170670 piccolo isoform 2 [Homo sapiens]                          93   1e-18
gi|150378539 piccolo isoform 1 [Homo sapiens]                          93   1e-18
gi|116284398 WAS/WASL interacting protein family, member 1 [Homo...    88   4e-17
gi|38373695 WAS/WASL interacting protein family, member 1 [Homo ...    88   4e-17
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   87   7e-17
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   87   7e-17
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   87   7e-17
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    87   7e-17
gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Hom...    84   8e-16
gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Hom...    84   8e-16
gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo sap...    84   8e-16
gi|160707881 formin 2 [Homo sapiens]                                   83   1e-15
gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens]             82   2e-15
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]         82   2e-15
gi|60460889 Myb protein P42POP [Homo sapiens]                          79   1e-14
gi|41281612 zinc finger protein 828 [Homo sapiens]                     79   2e-14
gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]          78   4e-14
gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]          78   4e-14

>gi|40353727 synaptopodin isoform A [Homo sapiens]
          Length = 903

 Score = 1828 bits (4736), Expect = 0.0
 Identities = 903/903 (100%), Positives = 903/903 (100%)

Query: 1   MEGYSEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPA 60
           MEGYSEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPA
Sbjct: 1   MEGYSEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPA 60

Query: 61  EVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSE 120
           EVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSE
Sbjct: 61  EVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSE 120

Query: 121 AQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSS 180
           AQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSS
Sbjct: 121 AQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSS 180

Query: 181 RPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTA 240
           RPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTA
Sbjct: 181 RPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTA 240

Query: 241 RPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMM 300
           RPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMM
Sbjct: 241 RPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMM 300

Query: 301 GQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVP 360
           GQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVP
Sbjct: 301 GQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVP 360

Query: 361 ASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEP 420
           ASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEP
Sbjct: 361 ASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEP 420

Query: 421 FALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKG 480
           FALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKG
Sbjct: 421 FALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKG 480

Query: 481 AELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTP 540
           AELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTP
Sbjct: 481 AELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTP 540

Query: 541 PASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVP 600
           PASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVP
Sbjct: 541 PASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVP 600

Query: 601 NLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQ 660
           NLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQ
Sbjct: 601 NLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQ 660

Query: 661 APRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPP 720
           APRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPP
Sbjct: 661 APRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPP 720

Query: 721 PLPPPPPMSPSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAENP 780
           PLPPPPPMSPSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAENP
Sbjct: 721 PLPPPPPMSPSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAENP 780

Query: 781 RPFSPPRAPPPPPPPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCTSPRS 840
           RPFSPPRAPPPPPPPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCTSPRS
Sbjct: 781 RPFSPPRAPPPPPPPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCTSPRS 840

Query: 841 PLPAPPRPFLYRRSPTDSDVSLDSEDSGAKSPGILGYNICPRGWNGSLRLKRGSLPAEAS 900
           PLPAPPRPFLYRRSPTDSDVSLDSEDSGAKSPGILGYNICPRGWNGSLRLKRGSLPAEAS
Sbjct: 841 PLPAPPRPFLYRRSPTDSDVSLDSEDSGAKSPGILGYNICPRGWNGSLRLKRGSLPAEAS 900

Query: 901 CTT 903
           CTT
Sbjct: 901 CTT 903


>gi|158303333 synaptopodin isoform B [Homo sapiens]
          Length = 685

 Score = 1349 bits (3491), Expect = 0.0
 Identities = 676/676 (100%), Positives = 676/676 (100%)

Query: 1   MEGYSEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPA 60
           MEGYSEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPA
Sbjct: 1   MEGYSEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPA 60

Query: 61  EVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSE 120
           EVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSE
Sbjct: 61  EVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSE 120

Query: 121 AQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSS 180
           AQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSS
Sbjct: 121 AQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSS 180

Query: 181 RPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTA 240
           RPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTA
Sbjct: 181 RPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTA 240

Query: 241 RPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMM 300
           RPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMM
Sbjct: 241 RPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMM 300

Query: 301 GQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVP 360
           GQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVP
Sbjct: 301 GQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVP 360

Query: 361 ASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEP 420
           ASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEP
Sbjct: 361 ASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEP 420

Query: 421 FALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKG 480
           FALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKG
Sbjct: 421 FALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKG 480

Query: 481 AELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTP 540
           AELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTP
Sbjct: 481 AELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTP 540

Query: 541 PASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVP 600
           PASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVP
Sbjct: 541 PASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVP 600

Query: 601 NLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQ 660
           NLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQ
Sbjct: 601 NLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQ 660

Query: 661 APRPSFSTRNAGIEAQ 676
           APRPSFSTRNAGIEAQ
Sbjct: 661 APRPSFSTRNAGIEAQ 676



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 68/239 (28%), Positives = 92/239 (38%), Gaps = 31/239 (12%)

Query: 638 SPPYGGDISPVSPSRAWSPR--AKQAPRPSFSTRNA---GIEAQDRRES-----LPTSPP 687
           SP    ++ P   S   SPR  AK  P+P+ +   A   G E   RR+S     +  S  
Sbjct: 441 SPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSS 500

Query: 688 WTPGASRPPSSLDGWVSPGPWE-----PGRGSSMSSPPPLPPPPPMSPSWSERSVSPLRP 742
            TP  +R PS       P  W+     PG     S  P   PP  +   +   +   LRP
Sbjct: 501 HTPELARCPSPTMSL--PSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPEN-GVLRP 557

Query: 743 ETEARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRM 802
           E   +PP +   +L   + I    +   SPR+A     +P S    P  P    PP P +
Sbjct: 558 EPTKQPPYQLRPSLFVLSPIKEPAK--VSPRAASPA--KPSSLDLVPNLPKGALPPSPAL 613

Query: 803 RSPQPARPGSAAVPGA-AFAPIPRSP------LPAGPSSCTSPRSPLPAPPRPFLYRRS 854
             P  + PG    PG  +  P   SP       P  PS   SPR+     PRP    R+
Sbjct: 614 PRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRA--KQAPRPSFSTRN 670


>gi|166706868 synaptopodin 2-like isoform a [Homo sapiens]
          Length = 977

 Score =  147 bits (370), Expect = 6e-35
 Identities = 157/530 (29%), Positives = 216/530 (40%), Gaps = 86/530 (16%)

Query: 233 PSVVNRTARPF--GIQA--PGGTSQMER--SPMLERRHFGEKAPAPQPPSLPDRSPRPQR 286
           PS+ NR+ARPF  G+Q   P  TS + R  +P       G  +PAP PP L  + P P  
Sbjct: 461 PSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAP-PPFLSSQGPTPLP 519

Query: 287 HIMSRSPMVERRMMGQRSPASE--------------RRPL--GNFTAPPTYTETLSTAPL 330
              S  P          +P S                RP+  G    PP      +    
Sbjct: 520 SFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTST 579

Query: 331 ASWVRSPPSYSVLYPSS--------DPKSSHLKGQAVPASKTGILEESMARRGSRKSMF- 381
           AS   S P      P +        +P S+  +  +VPA++TGIL+E+  RRG+RK MF 
Sbjct: 580 ASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGILQEA-RRRGTRKQMFR 638

Query: 382 TFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRD-RA 440
              E+ K +PNP+LL LVQ  DEK R     E G EE+  +LGAEA NF Q    R  + 
Sbjct: 639 PGKEETKNSPNPELLSLVQNLDEKPR-AGGAESGPEEDALSLGAEACNFMQPVGARSYKT 697

Query: 441 SPAAAEEVVPEWASCLKSPRIQAKPKP----KPNQNLSEA-----------------SGK 479
            P    +  P  A     P     P P     P++ L +                   G+
Sbjct: 698 LPHVTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGR 757

Query: 480 GAELYARRQSRMEKYVIESSSHTPELA---RCPSPTMSLPSSWKYPTNAPGAFRVASR-- 534
           G EL+A+RQSR ++YV+E +   P L    R PSPT SLP SWKY  N      +A    
Sbjct: 758 GGELFAKRQSRADRYVVEGTP-GPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPL 816

Query: 535 -SP-----ARTPPASLYHG--YLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPR 586
            SP     ART P +   G    P+ G+   +  +  PYQL+ ++F    +  P    P 
Sbjct: 817 LSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEV--PPTPGPI 874

Query: 587 AASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDIS 646
           A+   K + +  +      A  P+     P+  +P   T+  +   +    S P      
Sbjct: 875 ASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAP 934

Query: 647 PVSPSRAW----SPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGA 692
           P    R      S    Q  RP FS    G++A            W PGA
Sbjct: 935 PPEAPRGLGASPSSCGFQVARPRFSATRTGLQAH----------VWRPGA 974



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 178/777 (22%), Positives = 256/777 (32%), Gaps = 142/777 (18%)

Query: 189 SSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAP 248
           S+  LID   N LV++       R A   P +  S     +  P S ++       +  P
Sbjct: 68  SAMSLIDASGNQLVLTVQ-----RLADEGPVQSPSPHELQVLSPLSPLSPEPPGAPVPQP 122

Query: 249 GGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASE 308
                + RSP     ++GE       P+  ++  RP+R   +R               S 
Sbjct: 123 LQPGSL-RSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSP 181

Query: 309 RRPLGNFTAPPTYTETLSTAPLASW-----VRSPPSYSVLYPSSDPKSS-HL-------- 354
             P      PP+  ++  ++P  SW     ++ PP+ ++L P    +   HL        
Sbjct: 182 AEPAPTIPGPPSQGDSRVSSP--SWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVP 239

Query: 355 -------------KGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQT 401
                        K +     +   L+E   +    K   T        PNP    ++  
Sbjct: 240 HPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCR-TIASLLTAAPNPHSKGVLMF 298

Query: 402 ADEKRRQRDQ----------GEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPE 451
             +KRRQR +             G EEE        S   +E       S A +     +
Sbjct: 299 --KKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAF-----SDARSLTNQSD 351

Query: 452 WAS-CLKSPRIQAKPKPKPNQN------LSEASGKGAELYARRQSRMEKYVIESSSHTPE 504
           W S  L     +A  +    Q       LSE SG+G +L+ +++ R +       S T E
Sbjct: 352 WDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRAD-------SSTQE 404

Query: 505 LARCPSPTMSLPSSWKYPT---NAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPT- 560
           LAR     M      + P    +AP    V   SP   P AS    + P  G   P P+ 
Sbjct: 405 LARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASP-RPFQPGGGAPTPAPSI 463

Query: 561 -KQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLP-----KGALP-PSPAL 613
             +      P L    P        P A   A  S   L P  P     +G  P PS   
Sbjct: 464 FNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTS 523

Query: 614 PRPSRSSPGLYTSPGQDSLQPTAVSPPY-GGDISPVSPSRAWSPRAKQAPRPSFSTRNAG 672
             PS +      S  + S   TA S  Y      PV+P  A  P A  +     ST +  
Sbjct: 524 GVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIF 583

Query: 673 IEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGP------------------WEPGRGS 714
           + A  R  + P +P   PGA  PPS+ +  +S                     + PG+  
Sbjct: 584 LSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEE 643

Query: 715 SMSSPPP--------LPPPPPMSPSWSERSVSPLRPETEARPPSRQLQALLARNIINAAR 766
           + +SP P        L   P    + S      L    EA      +Q + AR+      
Sbjct: 644 TKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEA---CNFMQPVGARSYKTLPH 700

Query: 767 RKSASPRSAGAENPRPFSPPRAPPPPPPPP------------------PPPPRM------ 802
               +P     + P P +P   PP  P PP                  P PPR+      
Sbjct: 701 VTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGE 760

Query: 803 ----RSPQPARPGSAAVPGAAFAPIPRSPLPA---GPSSCTSP--RSPLPAPPRPFL 850
               R  +  R      PG    P PRSP P     PS   SP  R+P P    P L
Sbjct: 761 LFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLL 817



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 138/623 (22%), Positives = 207/623 (33%), Gaps = 159/623 (25%)

Query: 257 SPMLERRHFGEKAPAPQP-PSLPDRSPRP-QRHIMSRSPMVERRMMGQRSPASERRPLGN 314
           +P+   R F     AP P PS+ +RS RP    +  + P     +    +P      LG 
Sbjct: 442 APVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGG 501

Query: 315 FT-APPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMAR 373
            + APP +  +    PL S+    PS++ +  S  P +    G   P + T         
Sbjct: 502 LSPAPPPFLSSQGPTPLPSFTSGVPSHAPV--SGSPSTPRSSG---PVTATS-------- 548

Query: 374 RGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPF-----ALGAEAS 428
                S++       VTP                       G  E P      A+ + AS
Sbjct: 549 -----SLYIPAPSRPVTPG----------------------GAPEPPAPPSAAAMTSTAS 581

Query: 429 NFQQEPA-PRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARR 487
            F   P  P  R    A     PE             P     Q +S  + +   L   R
Sbjct: 582 IFLSAPLRPSARPEAPAPGPGAPE-------------PPSAREQRISVPAARTGILQEAR 628

Query: 488 QSRMEKYVIESSSHTPELARCPSPTM-SLPSSWKYPTNAPGAFRVASRSPARTPPASLYH 546
           +    K +        E    P+P + SL  +      A GA        A +  A   +
Sbjct: 629 RRGTRKQMFRPGKE--ETKNSPNPELLSLVQNLDEKPRAGGA-ESGPEEDALSLGAEACN 685

Query: 547 GYLPENG---VLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPA--KPSSLDLVPN 601
              P         P  T + P  + P        K P  ++P+   P   KP S  L+  
Sbjct: 686 FMQPVGARSYKTLPHVTPKTPPPMAP--------KTPPPMTPKTPPPVAPKPPSRGLLDG 737

Query: 602 LPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQA 661
           L  GA   S  +P P R             LQ        GG++     SRA     +  
Sbjct: 738 LVNGAAS-SAGIPEPPR-------------LQGR------GGELFAKRQSRADRYVVEGT 777

Query: 662 PRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPPP 721
           P P    R             P SP  TP  S PPS          W+     ++ +PPP
Sbjct: 778 PGPGLGPR-------------PRSPSPTP--SLPPS----------WK--YSPNIRAPPP 810

Query: 722 LPPPPPMSPSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRK------------- 768
           +   P +SP + + + +  + +++  P +   Q + A + +     +             
Sbjct: 811 IAYNPLLSPFFPQAARTLPKAQSQG-PRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPP 869

Query: 769 ------SASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQPA--------RPGSAA 814
                 S SP++A  +  R FS    P P P   P  P + +P+ A        R   A+
Sbjct: 870 TPGPIASGSPKTARVQEIRRFS---TPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELAS 926

Query: 815 VPGAAFAPIPRSP--LPAGPSSC 835
            P  + AP P +P  L A PSSC
Sbjct: 927 APVPSPAPPPEAPRGLGASPSSC 949



 Score = 37.0 bits (84), Expect = 0.083
 Identities = 34/103 (33%), Positives = 39/103 (37%), Gaps = 24/103 (23%)

Query: 791 PPPPPPPPPPRMRSPQPARPGSAAVP---------------GAAFAPIPRSPLPAGPSSC 835
           P  P  P PP    PQP +PGS   P               G A    PR P   GP+  
Sbjct: 106 PLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTRP 165

Query: 836 TSPRSP--------LPAPPRPFL-YRRSPTDSDVSLDSEDSGA 869
           T P +P         PA P P +    S  DS VS  S + GA
Sbjct: 166 TPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGA 208


>gi|50301232 synaptopodin 2-like isoform b [Homo sapiens]
          Length = 753

 Score =  147 bits (370), Expect = 6e-35
 Identities = 157/530 (29%), Positives = 216/530 (40%), Gaps = 86/530 (16%)

Query: 233 PSVVNRTARPF--GIQA--PGGTSQMER--SPMLERRHFGEKAPAPQPPSLPDRSPRPQR 286
           PS+ NR+ARPF  G+Q   P  TS + R  +P       G  +PAP PP L  + P P  
Sbjct: 237 PSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAP-PPFLSSQGPTPLP 295

Query: 287 HIMSRSPMVERRMMGQRSPASE--------------RRPL--GNFTAPPTYTETLSTAPL 330
              S  P          +P S                RP+  G    PP      +    
Sbjct: 296 SFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTST 355

Query: 331 ASWVRSPPSYSVLYPSS--------DPKSSHLKGQAVPASKTGILEESMARRGSRKSMF- 381
           AS   S P      P +        +P S+  +  +VPA++TGIL+E+  RRG+RK MF 
Sbjct: 356 ASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGILQEA-RRRGTRKQMFR 414

Query: 382 TFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRD-RA 440
              E+ K +PNP+LL LVQ  DEK R     E G EE+  +LGAEA NF Q    R  + 
Sbjct: 415 PGKEETKNSPNPELLSLVQNLDEKPR-AGGAESGPEEDALSLGAEACNFMQPVGARSYKT 473

Query: 441 SPAAAEEVVPEWASCLKSPRIQAKPKP----KPNQNLSEA-----------------SGK 479
            P    +  P  A     P     P P     P++ L +                   G+
Sbjct: 474 LPHVTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGR 533

Query: 480 GAELYARRQSRMEKYVIESSSHTPELA---RCPSPTMSLPSSWKYPTNAPGAFRVASR-- 534
           G EL+A+RQSR ++YV+E +   P L    R PSPT SLP SWKY  N      +A    
Sbjct: 534 GGELFAKRQSRADRYVVEGTP-GPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPL 592

Query: 535 -SP-----ARTPPASLYHG--YLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPR 586
            SP     ART P +   G    P+ G+   +  +  PYQL+ ++F    +  P    P 
Sbjct: 593 LSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEV--PPTPGPI 650

Query: 587 AASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDIS 646
           A+   K + +  +      A  P+     P+  +P   T+  +   +    S P      
Sbjct: 651 ASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAP 710

Query: 647 PVSPSRAW----SPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGA 692
           P    R      S    Q  RP FS    G++A            W PGA
Sbjct: 711 PPEAPRGLGASPSSCGFQVARPRFSATRTGLQAH----------VWRPGA 750



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 115/449 (25%), Positives = 153/449 (34%), Gaps = 82/449 (18%)

Query: 473 LSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPT---NAPGAF 529
           LSE SG+G +L+ +++ R +       S T ELAR     M      + P    +AP   
Sbjct: 156 LSEVSGRGVQLFEQQRQRAD-------SSTQELARVEPAAMLNGEGLQSPPRAQSAPPEA 208

Query: 530 RVASRSPARTPPASLYHGYLPENGVLRPEPT--KQPPYQLRPSLFVLSPIKEPAKVSPRA 587
            V   SP   P AS    + P  G   P P+   +      P L    P        P A
Sbjct: 209 AVLPPSPLPAPVASP-RPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLA 267

Query: 588 ASPAKPSSLDLVPNLP-----KGALP-PSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPY 641
              A  S   L P  P     +G  P PS     PS +      S  + S   TA S  Y
Sbjct: 268 PKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLY 327

Query: 642 -GGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLD 700
                 PV+P  A  P A  +     ST +  + A  R  + P +P   PGA  PPS+ +
Sbjct: 328 IPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSARE 387

Query: 701 GWVSPGP------------------WEPGRGSSMSSPPP--------LPPPPPMSPSWSE 734
             +S                     + PG+  + +SP P        L   P    + S 
Sbjct: 388 QRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESG 447

Query: 735 RSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPP 794
                L    EA      +Q + AR+          +P     + P P +P   PP  P 
Sbjct: 448 PEEDALSLGAEA---CNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTPPPVAPK 504

Query: 795 PP------------------PPPPRM----------RSPQPARPGSAAVPGAAFAPIPRS 826
           PP                  P PPR+          R  +  R      PG    P PRS
Sbjct: 505 PPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRS 564

Query: 827 PLPA---GPSSCTSP--RSPLPAPPRPFL 850
           P P     PS   SP  R+P P    P L
Sbjct: 565 PSPTPSLPPSWKYSPNIRAPPPIAYNPLL 593



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 138/623 (22%), Positives = 207/623 (33%), Gaps = 159/623 (25%)

Query: 257 SPMLERRHFGEKAPAPQP-PSLPDRSPRP-QRHIMSRSPMVERRMMGQRSPASERRPLGN 314
           +P+   R F     AP P PS+ +RS RP    +  + P     +    +P      LG 
Sbjct: 218 APVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGG 277

Query: 315 FT-APPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMAR 373
            + APP +  +    PL S+    PS++ +  S  P +    G   P + T         
Sbjct: 278 LSPAPPPFLSSQGPTPLPSFTSGVPSHAPV--SGSPSTPRSSG---PVTATS-------- 324

Query: 374 RGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPF-----ALGAEAS 428
                S++       VTP                       G  E P      A+ + AS
Sbjct: 325 -----SLYIPAPSRPVTPG----------------------GAPEPPAPPSAAAMTSTAS 357

Query: 429 NFQQEPA-PRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARR 487
            F   P  P  R    A     PE             P     Q +S  + +   L   R
Sbjct: 358 IFLSAPLRPSARPEAPAPGPGAPE-------------PPSAREQRISVPAARTGILQEAR 404

Query: 488 QSRMEKYVIESSSHTPELARCPSPTM-SLPSSWKYPTNAPGAFRVASRSPARTPPASLYH 546
           +    K +        E    P+P + SL  +      A GA        A +  A   +
Sbjct: 405 RRGTRKQMFRPGKE--ETKNSPNPELLSLVQNLDEKPRAGGA-ESGPEEDALSLGAEACN 461

Query: 547 GYLPENG---VLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPA--KPSSLDLVPN 601
              P         P  T + P  + P        K P  ++P+   P   KP S  L+  
Sbjct: 462 FMQPVGARSYKTLPHVTPKTPPPMAP--------KTPPPMTPKTPPPVAPKPPSRGLLDG 513

Query: 602 LPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQA 661
           L  GA   S  +P P R             LQ        GG++     SRA     +  
Sbjct: 514 LVNGAAS-SAGIPEPPR-------------LQGR------GGELFAKRQSRADRYVVEGT 553

Query: 662 PRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPPP 721
           P P    R             P SP  TP  S PPS          W+     ++ +PPP
Sbjct: 554 PGPGLGPR-------------PRSPSPTP--SLPPS----------WK--YSPNIRAPPP 586

Query: 722 LPPPPPMSPSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRK------------- 768
           +   P +SP + + + +  + +++  P +   Q + A + +     +             
Sbjct: 587 IAYNPLLSPFFPQAARTLPKAQSQG-PRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPP 645

Query: 769 ------SASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQPA--------RPGSAA 814
                 S SP++A  +  R FS    P P P   P  P + +P+ A        R   A+
Sbjct: 646 TPGPIASGSPKTARVQEIRRFS---TPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELAS 702

Query: 815 VPGAAFAPIPRSP--LPAGPSSC 835
            P  + AP P +P  L A PSSC
Sbjct: 703 APVPSPAPPPEAPRGLGASPSSC 725


>gi|193083183 synaptopodin 2 isoform a [Homo sapiens]
          Length = 1261

 Score =  119 bits (299), Expect = 1e-26
 Identities = 109/329 (33%), Positives = 147/329 (44%), Gaps = 51/329 (15%)

Query: 469  PNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNA--- 525
            P+  L   SG+GA+L+A+RQSRMEKYV++S +     AR  SPT SLP+SWKY +N    
Sbjct: 861  PSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSPTPSLPASWKYSSNVRAP 920

Query: 526  -PGAFR----------VASRSPARTPPASL--YHGYLPENGVLRPEPTKQPPYQLRPSLF 572
             P A+                P+   P+ +    G  P N +   +  K  PYQL  SLF
Sbjct: 921  PPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNAL---DVMKHQPYQLNASLF 977

Query: 573  VLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPA-------LPRPSRSSPGLYT 625
               P  +     P+ +S    S+L +     K ALPP P        +   S  S   YT
Sbjct: 978  TFQP-PDAKDGLPQKSSVKVNSALAM-----KQALPPRPVNAASPTNVQASSVYSVPAYT 1031

Query: 626  SPGQ---DSLQPTAVSP-PYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRES 681
            SP     ++  P + SP P G   SP   S + S     APRP FS + +G+  Q+   S
Sbjct: 1032 SPPSFFAEASSPVSASPVPVGIPTSPKQESASSSYFV--APRPKFSAKKSGVTIQESGRS 1089

Query: 682  LPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPPP--LPPPPPMSPSWSERSVSP 739
            L       PG S PP      +S  PW      S SS P   L         W   + SP
Sbjct: 1090 LS-----LPGRSVPPP-----ISTSPWVYQPTYSYSSKPTDGLEKANKRPTPWEAAAKSP 1139

Query: 740  LRPETEARPPSRQLQALLARNIINAARRK 768
            L    +A  P R +Q  +  N+++AARRK
Sbjct: 1140 LGLVDDAFQP-RNIQESIVANVVSAARRK 1167



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 100/476 (21%), Positives = 162/476 (34%), Gaps = 91/476 (19%)

Query: 473 LSEASGKGAELYARRQSRMEKYVIESSSH----TPELARCPSPTMSLPSSWKYPTNAPGA 528
           L + +GKGA ++A+R+ RM++   +        TP   +  + T  L ++  Y      +
Sbjct: 484 LPDTTGKGALMFAKRRERMDQITAQKEEDKVGGTPSREQDAAQTDGLRTTTSYQRKEEES 543

Query: 529 FRV----------ASRSPARTPPASLYHG---------YLPENGVLRPEP--TKQPPYQL 567
            R            S      P  + + G          +P N   +P P    QP    
Sbjct: 544 VRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANIQRMVPMNRTAKPFPGSVNQPATPF 603

Query: 568 RPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSR-SSPGLYTS 626
            P+  + SPI +     P +A    P +     + P       P  P+P+  S P  Y S
Sbjct: 604 SPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAFYDS 663

Query: 627 PGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSP 686
             + + +   +S P                + +   +P F+ +   +       SL  + 
Sbjct: 664 SERIASRDERISVP------AKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNS 717

Query: 687 PWT--PGASRPPSSLDGWVSPGP----WEPGRGSSMSSPPPLPPPP-----------PMS 729
                 GA       + ++S G     +     +   +PPP+ P P           P+S
Sbjct: 718 EGKRGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVS 777

Query: 730 PSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAEN-PRPFSPPRA 788
           P WS   V+P +P   A P S   +  +  + I  A+      R A   N   PF  P+A
Sbjct: 778 PVWSP-GVAPTQP--PAFPTSNPSKGTVVSS-IKIAQPSYPPARPASTLNVAGPFKGPQA 833

Query: 789 PPP----PPPPPPPPPRMRSPQPARPG-SAAVPG-------------------------- 817
                   P P    P + + QP   G S  +PG                          
Sbjct: 834 AVASQNYTPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTV 893

Query: 818 ---AAFAPIPRSPLPAGPSSCTSPRSPLPAPPRPFLYRRSPTDSDVSLDSEDSGAK 870
              AA A  P   LPA     ++ R+P P    P     SP+    +L S+ S A+
Sbjct: 894 QAHAARAQSPTPSLPASWKYSSNVRAPPPVAYNPI---HSPSYPLAALKSQPSAAQ 946


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score =  115 bits (288), Expect = 2e-25
 Identities = 212/874 (24%), Positives = 306/874 (35%), Gaps = 130/874 (14%)

Query: 55   PAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSI 114
            P  P A  + P A   QN  +P ATL      +   P +      PPA   P +  +  I
Sbjct: 699  PLVPTASENCPVAPSPQNTCAPLATLVL----APEIPKSVPSPSLPPAGTPPGTKKVDGI 754

Query: 115  QQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREA 174
               S+ A + S+   P   P+    D    A A      T L D  S    + S  ++  
Sbjct: 755  SHTSALAPVASS---PKECPT---EDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRP 808

Query: 175  TLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTL--AKP 232
                 S  P  D    +L   + P       +  +S + +  +P   +S    +   A  
Sbjct: 809  PTKKGSAGP--DTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPT 866

Query: 233  PSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAP-QPPSLPDRSPRPQRHIMSR 291
            PS V   + P G+  P   +       L     G   PAP Q P+L   S  P++   + 
Sbjct: 867  PSAVTPLS-PKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATP 925

Query: 292  SPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKS 351
            +P          SP+ +  P      PP+     +T P   W  +PP+ +   P   P +
Sbjct: 926  APKGI-----PASPSPKGAPTPPAATPPSPKGGPAT-PSPKWAPTPPAATPPSPKGGPAT 979

Query: 352  SHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQ 411
               KG   P + T    +      S K   T    P VTP         T   K      
Sbjct: 980  PSPKGAPTPPAATPPSPKGGPATPSPKGAPT---PPAVTPPSPKGSPAATPFPKGASTPP 1036

Query: 412  GEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQ 471
                    P   G+ A+    + AP   A+   + +  P   S   +P   A   P P  
Sbjct: 1037 AAT----PPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKG 1092

Query: 472  NLSEASGKGAELYARRQSRMEKYVIESSSH----TPELARCPSPT--MSLPSSWKYPTN- 524
              +  S KGA +         K  + +  H    T   A  PSP   ++ P     PT  
Sbjct: 1093 GPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTP 1152

Query: 525  -----------APGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQP--PYQLRPSL 571
                       A    + A  +PA TPP+       P+ G+  P P   P  P    PS 
Sbjct: 1153 AATPPSPKGGLATPPPKGAPTTPAATPPS-------PKGGLATPSPKGAPTTPAATPPSP 1205

Query: 572  --FVLSPIKEPAKVSPRAASPA------------KPSSLDLVPNLPKG--ALPPSPALPR 615
               + +P  + A  +P A  P+             P++    P  PKG  A PP    P 
Sbjct: 1206 KGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPT 1265

Query: 616  PSRSSP-----GLYTSPGQDSLQPTAVSP--PYGGD-------------ISPVSPSRA-W 654
            P  ++P     GL T P + +  P  V+P  P GG               +P SP  +  
Sbjct: 1266 PPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPG 1325

Query: 655  SPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPG-------- 706
            +P  K AP P   T      +     +LP + P + G    PSS +G   P         
Sbjct: 1326 TPPPKGAPTPPAVTP----PSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGG 1381

Query: 707  ----PWEPGRGSSMSSP----------PPLPPPPPMSPSWSERSVSPLRPETEARPPSRQ 752
                P  P RG ++ SP          P  P   P +P   E + +P   + +  PP+  
Sbjct: 1382 PAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATP--SKGDLTPPAVT 1439

Query: 753  LQALLARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQPAR-PG 811
              +L      +A +   A+P S G     P  P   PP P  PP P     S  P + P 
Sbjct: 1440 PVSLKKAPATSAPKGGPATPSSKG----DPTLPAVTPPSPKEPPAPKQVATSSSPKKAPA 1495

Query: 812  SAAVPGAAFAP--IPRSP--LPAGPSSCTSPRSP 841
            + A  GA   P  IP SP  +PA PSS   P +P
Sbjct: 1496 TPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAP 1529



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 207/860 (24%), Positives = 296/860 (34%), Gaps = 101/860 (11%)

Query: 59   PAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNS 118
            PA    PA+   +   +P A  T P+       P+      PPA   P S        + 
Sbjct: 925  PAPKGIPASPSPKGAPTPPAA-TPPSPKGGPATPSPKWAPTPPAAT-PPSPKGGPATPSP 982

Query: 119  SEAQLPSNGTGPASK--PSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATL 176
              A  P   T P+ K  P+T    G P  PA              +PA T   F + A+ 
Sbjct: 983  KGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPK------GSPAATP--FPKGAST 1034

Query: 177  IPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVV 236
             P++ PP+     S     +        A    S +    TP+   +      A PPS  
Sbjct: 1035 PPAATPPSPK--GSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTP-PAATPPSPK 1091

Query: 237  NRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQP--PSLPDRSPRPQRHIMSRSPM 294
               A P    AP   +    SP       G  A  P    P+ P  +P   +  ++  P 
Sbjct: 1092 GGPATPSPKGAPMPPAATPPSPK------GGLATPPHKGAPTTPAATPPSPKGGLATPPP 1145

Query: 295  VERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHL 354
                     +P S   P G    PP   +   T P A+    PPS      +  PK +  
Sbjct: 1146 KGAPTTPAATPPS---PKGGLATPPP--KGAPTTPAAT----PPSPKGGLATPSPKGAPT 1196

Query: 355  KGQAVPASKTGILEESMARRGSRKSMFTFVEKPK---VTPNPDLLDLVQTA---DEKRRQ 408
               A P S  G L  + + +G+  +       PK    TP+P        A     K   
Sbjct: 1197 TPAATPPSPKGGLA-TPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGP 1255

Query: 409  RDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPK-- 466
                  G    P A           P  +   +PA      P+       P+    P   
Sbjct: 1256 ATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAA 1315

Query: 467  --PKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTN 524
              P P  +      KGA           K      + TP     P+     PSS + PT 
Sbjct: 1316 TPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTT----PSSKEGPT- 1370

Query: 525  APGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVS 584
             P A       PA TPP+       P+ G   P P   P     P++  LSP K PA   
Sbjct: 1371 PPAATPSHKGGPAMTPPS-------PKRGPAIPSPKGDPT---SPAVIPLSPKKAPATPV 1420

Query: 585  PRAASPAKPSSLDLVPN-LPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGG 643
             R  + A PS  DL P  +   +L  +PA   P +  P   +S G  +L   AV+PP   
Sbjct: 1421 TREGA-ATPSKGDLTPPAVTPVSLKKAPATSAP-KGGPATPSSKGDPTLP--AVTPP--- 1473

Query: 644  DISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSP---PWTPGASRPP---- 696
              SP  P          +P+ + +T  A + A      +P+SP   P TP + R P    
Sbjct: 1474 --SPKEPPAPKQVATSSSPKKAPATP-APMGAPTLPAVIPSSPKEVPATPSSRRDPIAPT 1530

Query: 697  SSLDGWVSPGPWEPGRG--------SSMSSPPPLPPPP--PMSPSWSERSVSP-LRPETE 745
            ++L    +P    P            S    P +P P   P +PS  E S  P + P T 
Sbjct: 1531 ATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTY 1590

Query: 746  ARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSP 805
               PS + + L+   + + + +++ +P +    +P       AP   P  PP  P     
Sbjct: 1591 KGAPSPK-ELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKD 1649

Query: 806  QPARPGSAAVPGAAFAPIPRSPLPA--GPSS------CTSPRSP--LPAPPR--PFLYRR 853
             P  P S      A  P     LPA  GP++        +P S   + AP R  P   + 
Sbjct: 1650 SPTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKS 1709

Query: 854  SPTDSDVSLD-SEDSGAKSP 872
            S T   +  D S  +G+K P
Sbjct: 1710 SATSPPICPDPSAKNGSKGP 1729



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 202/876 (23%), Positives = 310/876 (35%), Gaps = 184/876 (21%)

Query: 77   SATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQN----SSEAQLPSNGTGPA- 131
            S+T  +  S  S  PP    N+  PATV    +   S+ +     SS    PS     A 
Sbjct: 344  SSTGASYPSQRSVIPPLPSRNEVVPATVAAFPVVAPSVDKGPSTISSITCSPSGSLNVAT 403

Query: 132  ----SKPSTLCADGQPQA----------PAEEVRCSTLLIDKVSTPATTTSTFSREATLI 177
                S  ++L     P A          P   V  + L++    T A   +T    AT +
Sbjct: 404  SFSLSPTTSLILKSSPNATYHYPLVAQMPVSSVGTTPLVVTNPCTIAAAPTTTFEVATCV 463

Query: 178  PSSRPPASDFMSSSLLIDIQPNT---LVVS--ADQEMSGRAAATT----------PTKVY 222
                PP    MSS  + +I+P +   LV++  A +E S + A T           P  + 
Sbjct: 464  S---PP----MSSGPISNIEPTSPAALVMAPVAPKEPSTQVATTLRIPVSPPLPDPEDLK 516

Query: 223  SEVHFTLAKPPSVVNRTARPFGIQ-APGGTSQMERSPMLERRHFGEKAPAPQ-PPSLPDR 280
            +     L K P+  +    P  ++ AP   +Q   +   +         AP+  PS    
Sbjct: 517  NLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPSFQST 576

Query: 281  SPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSY 340
            S  P+  +   + +  ++ +G+  P    +P  + T+P     + S     S        
Sbjct: 577  SSSPEIPLSPEATLA-KKSLGEPLPIG--KPASSMTSPLGVNSSASVIKTDS-------- 625

Query: 341  SVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQ 400
               Y   D     LK   +  +      ES    G   +          T +P L   V 
Sbjct: 626  ---YAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGTSTYTTTASPFLEGTVS 682

Query: 401  TADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPR 460
             A +    ++     +   P A    + N    P+P++  +P A   + PE    + SP 
Sbjct: 683  LAPKNHPVKEGTLTTLPLVPTA----SENCPVAPSPQNTCAPLATLVLAPEIPKSVPSPS 738

Query: 461  IQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWK 520
            +     P   +                        ++  SHT  LA    P  S P   +
Sbjct: 739  LPPAGTPPGTKK-----------------------VDGISHTSALA----PVASSPK--E 769

Query: 521  YPTNAPGAFRVASRSPARTPPASLYHGYLPEN----GVLRPEPTKQPPYQLRPSLFVLSP 576
             PT   GA   AS     T        YL ++    GV     TK+PP + + S    +P
Sbjct: 770  CPTEDSGASATASSKGTLT--------YLADSPSPLGVSVSPQTKRPPTK-KGSAGPDTP 820

Query: 577  IKE-PAKVSPRAASPAKPSSLDL-------------VPNLPKGALPPSPALPRPSRSSPG 622
            I    + VSP  AS    +SL                P  PKGA  PS   P     SP 
Sbjct: 821  IGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPL----SPK 876

Query: 623  LYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAG-IEAQDRRES 681
              T P +++  P+ V+ P+  +  P +P+       KQAP  S ++ +     A    + 
Sbjct: 877  GVTLPPKETPTPSVVNLPFPKE-GPATPA------PKQAPALSMTSSSPKKARATPAPKG 929

Query: 682  LPTSPPW----TPGASRPPSSLDGWVSPGP-WEPGRGSSMSSPPPLPPPPPMSPSWSERS 736
            +P SP      TP A+ PPS   G  +P P W P       +PP   PP P         
Sbjct: 930  IPASPSPKGAPTPPAATPPSPKGGPATPSPKWAP-------TPPAATPPSPKG------- 975

Query: 737  VSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAENPR--PFSP-PRAPPPPP 793
              P  P  +  P                      +P +A   +P+  P +P P+  P PP
Sbjct: 976  -GPATPSPKGAP----------------------TPPAATPPSPKGGPATPSPKGAPTPP 1012

Query: 794  PPPPPPPRMRSPQPARPGSAAVPGAAFAPIPR-----SPLPAGPSSCTSPRSPLPAP--- 845
               PP P+        P  A+ P AA  P P+     +PLP G  + T+P + LP+P   
Sbjct: 1013 AVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKG--APTTPAATLPSPKGG 1070

Query: 846  PRPFLYRRSPTDSDVSLDSEDSGAKSPGILGYNICP 881
            P     + +PT    +  S   G  +P   G  + P
Sbjct: 1071 PATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPP 1106



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 206/904 (22%), Positives = 302/904 (33%), Gaps = 136/904 (15%)

Query: 56   APPPAEVHSPAADVNQNLA--SPSATL-------TTPTSNSSHNPPAT--DVNQNPPATV 104
            A PP+   SPAA      A  +P+ATL        TP+   +  PPA      +  PAT 
Sbjct: 1038 ATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATP 1097

Query: 105  VPQSLPLSSIQQNSSE----AQLPSNG--TGPASKPSTLCADGQPQAPAEEVRCSTLLID 158
             P+  P+       S     A  P  G  T PA+ P +    G    P  +   +T    
Sbjct: 1098 SPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPS--PKGGLATPPPKGAPTTPAAT 1155

Query: 159  KVSTPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSG------R 212
              S      +   + A   P++ PP+     ++      P T   +      G      +
Sbjct: 1156 PPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPK 1215

Query: 213  AAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERS----PMLERRHFGEK 268
             A TTP           A PPS     A P    AP   +    S    P          
Sbjct: 1216 GAPTTPA----------ATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPT 1265

Query: 269  APAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTA 328
             PA  PPSL      P  H  + +P V      +  PA+   P G  T P     +   +
Sbjct: 1266 PPAATPPSLKGGLATPP-HKGAPNPAVVTPPSPKGGPATS-PPKGAPTPPAATPPSPKGS 1323

Query: 329  PLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPK 388
            P     +  P+   + P S PK +       P+SK G    S ++ G           P 
Sbjct: 1324 PGTPPPKGAPTPPAVTPPS-PKGTPTLPATTPSSKGGPTTPS-SKEGP--------TPPA 1373

Query: 389  VTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEV 448
             TP+      +     KR        G    P  +          P  R+ A+  +  ++
Sbjct: 1374 ATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDL 1433

Query: 449  VPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRME----KYVIESSS---- 500
             P   + +   +  A   PK       + G          S  E    K V  SSS    
Sbjct: 1434 TPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKA 1493

Query: 501  -HTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEP 559
              TP     P+    +PSS K     P     +SR     P A+L     P    L P+ 
Sbjct: 1494 PATPAPMGAPTLPAVIPSSPKEVPATP-----SSRRDPIAPTATLLSKKTP--ATLAPKE 1546

Query: 560  TKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLD------LVPNLPKGALPPSPAL 613
               P     P++ V SP K PA  +P+ A PA PSS +      + P+  KGA  P   L
Sbjct: 1547 ALIP-----PAMTVPSPKKTPAIPTPKEA-PATPSSKEASSPPAVTPSTYKGAPSPKELL 1600

Query: 614  PRPSRSSPGLYTSPGQDSLQPTAVSP--PYGGDISPVSPSRAWSPRAKQAPRPSFSTRNA 671
              P+ +SP    +P      P AV+P  P  G  +P       SP    +      T  A
Sbjct: 1601 IPPAVTSPSPKEAP-----TPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPA 1655

Query: 672  GIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWE-----------PGRGSSMSSPP 720
             +  +    ++P +    P    P +  +  V+P P             P    S ++ P
Sbjct: 1656 SVTCK-MGATVPQASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSP 1714

Query: 721  PLPP----------------PPPMSPSWSERSVSPL------RPETEARPPSRQLQALLA 758
            P+ P                P P+ P   + S +         P+    PP  +    L 
Sbjct: 1715 PICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLT 1774

Query: 759  RNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPPPP------PPPPRMRSPQPARPGS 812
                     K  S   + A +P P S P AP P P  P      P  P +    P++P +
Sbjct: 1775 AAAFEKVLPKPESASVSAAPSP-PVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLA 1833

Query: 813  AAVPGAAFAPIPRSPLPAGPS------SCTSPRS---PLPAPPRPFLYRRSPTDSDVSLD 863
             A        IP  P+  G        +  +P+S   P+P P       ++   S    D
Sbjct: 1834 PADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESD 1893

Query: 864  SEDS 867
            S++S
Sbjct: 1894 SDES 1897



 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 161/713 (22%), Positives = 239/713 (33%), Gaps = 163/713 (22%)

Query: 41   GLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNP 100
            GL    ++ A   +   PP+    PA    +   +P A  T P+   S   P       P
Sbjct: 1277 GLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAA-TPPSPKGSPGTPPPKGAPTP 1335

Query: 101  PATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKV 160
            PA   P                     T PA+ PS   + G P  P+ +        +  
Sbjct: 1336 PAVTPPSP---------------KGTPTLPATTPS---SKGGPTTPSSK--------EGP 1369

Query: 161  STPATTTSTFSREATLIPSSR-----PPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAA 215
            + PA T S     A   PS +     P      +S  +I + P      A      R  A
Sbjct: 1370 TPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPK----KAPATPVTREGA 1425

Query: 216  TTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPP 275
             TP+K           PP+V      P  ++    TS  +  P           PA  PP
Sbjct: 1426 ATPSK-------GDLTPPAVT-----PVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPP 1473

Query: 276  SLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVR 335
            S P   P P++   S SP        +++PA+   P+G  T P     +    P     R
Sbjct: 1474 S-PKEPPAPKQVATSSSP--------KKAPATP-APMGAPTLPAVIPSSPKEVPATPSSR 1523

Query: 336  SPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDL 395
              P    + P++   S   K  A  A K  ++  +M            V  PK TP    
Sbjct: 1524 RDP----IAPTATLLSK--KTPATLAPKEALIPPAMT-----------VPSPKKTP---- 1562

Query: 396  LDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASC 455
               + T  E        E      P A+    S ++  P+P++   P A     P+    
Sbjct: 1563 --AIPTPKEAPATPSSKEA---SSPPAV--TPSTYKGAPSPKELLIPPAVTSPSPK---- 1611

Query: 456  LKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSL 515
             ++P   A   P P +  +  + KG                            P+     
Sbjct: 1612 -EAPTPPAVTPPSPEKGPATPAPKGT---------------------------PTSPPVT 1643

Query: 516  PSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLS 575
            PSS K    +P +  V  +  A  P AS            +  P K+ P  L+  L   +
Sbjct: 1644 PSSLKDSPTSPAS--VTCKMGATVPQAS------------KGLPAKKGPTALKEVLVAPA 1689

Query: 576  PIKEPAKVSPRAASP-AKPSSLDLVPNLP--------KGAL---PPSPALPRPSRSSPGL 623
            P   P   +P    P  K SS    P  P        KG L    P+P LP    SS   
Sbjct: 1690 PESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSK-- 1747

Query: 624  YTSPGQDSLQPT--AVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRES 681
             T+ G+D+       ++PP     +P++ +       K  P+P  ++ +A   A     S
Sbjct: 1748 -TAKGKDASHSPKGPLAPPESKASTPLTAAAF----EKVLPKPESASVSA---APSPPVS 1799

Query: 682  LPTSPPWTPGASRPPS-----SLDGWVSPGPWEPGRGSSMSSPPPLPPPPPMS 729
            LP +P  +P  + PP      S  G V   P +P   +      PL PP P+S
Sbjct: 1800 LPLAP--SPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPIS 1850



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 193/874 (22%), Positives = 296/874 (33%), Gaps = 153/874 (17%)

Query: 64  SPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPP----ATVVPQSLPLSSIQQNSS 119
           S A  V   L  P  TL  P S +    P +  NQ  P    +T+    L +    Q+SS
Sbjct: 29  SSALSVTAALGQPGPTLPPPCSPAPQQCPLSAANQASPFPSPSTIASTPLEVP-FPQSSS 87

Query: 120 EAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPS 179
              LP  GT P +        G P +PA     S ++   +    ++++  +  A L P 
Sbjct: 88  GTALPL-GTAPEAPTFLPNLIGPPISPAALALASPMIAPTLKGTPSSSAPLALVA-LAPH 145

Query: 180 SRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRT 239
           S   +S F  + L     P ++ V+    +   +A   P    SE    L K PS V   
Sbjct: 146 SVQKSSAFPPNLLT---SPPSVAVAESGSVITLSAPIAP----SEPKTNLNKVPSEV--- 195

Query: 240 ARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRM 299
                +  P GT                    P PP +    P    H ++    ++   
Sbjct: 196 -----VPNPKGT--------------------PSPPCIVSTVPY---HCVTPMASIQ--- 224

Query: 300 MGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAV 359
                            + P  T T + A  +  V+     SVL    +P S  LKG   
Sbjct: 225 -------------SGVASLPQTTPTTTLAIASPQVKDTTISSVLISPQNPGSLSLKGPVS 271

Query: 360 PASKTGILEESMARRGSRKSMFTFVEKPKVTPN--PDLLDLVQTADEKRRQRDQGEVGV- 416
           P +   +  +S+        + T  +K    PN  PD    + +      Q   G V + 
Sbjct: 272 PPAALSLSTQSL-------PVVTSSQK-TAGPNTPPDFPISLGSHLAPLHQSSFGSVQLL 323

Query: 417 -EEEPFALG---------AEASNFQQEPAPRDRASP-AAAEEVVPEWASCL--------K 457
            +  P AL            +S     P+ R    P  +  EVVP   +          K
Sbjct: 324 GQTGPSALSDPTVKTISVDHSSTGASYPSQRSVIPPLPSRNEVVPATVAAFPVVAPSVDK 383

Query: 458 SPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCP-SPTMSLP 516
            P   +     P+ +L+ A+       +   S + K    ++ H P +A+ P S   + P
Sbjct: 384 GPSTISSITCSPSGSLNVATSFS---LSPTTSLILKSSPNATYHYPLVAQMPVSSVGTTP 440

Query: 517 SSWKYPTNAPGA----FRVAS--RSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPS 570
                P     A    F VA+    P  + P S      P   V+ P   K+P  Q+  +
Sbjct: 441 LVVTNPCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVAPKEPSTQVATT 500

Query: 571 LF--VLSPIKEP--AKVSPRAASPAKPSSLDL--VPNLPKGALPPSPALPRPSRSSPGLY 624
           L   V  P+ +P   K  P +     P+  DL  VP   +GA P SPA         GL 
Sbjct: 501 LRIPVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGA-PFSPA-------QAGLT 552

Query: 625 TSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPT 684
           T      L     +P      SP   S + SP    +P  + + ++ G      + +   
Sbjct: 553 TKKDPTVLPLVQAAPKN----SPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSM 608

Query: 685 SPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPP----PLPPPPP--MSPSWSERSVS 738
           + P    +S      D +  P    P   SS+ +P     PL    P  ++P+ ++ + +
Sbjct: 609 TSPLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGTST 668

Query: 739 PLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPPPPP- 797
                T A P      +L  +N           P   G     P  P  +   P  P P 
Sbjct: 669 ---YTTTASPFLEGTVSLAPKN----------HPVKEGTLTTLPLVPTASENCPVAPSPQ 715

Query: 798 ---PPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAPPRPFLYRRS 854
               P       P  P S   P    A  P         S TS  +P+ + P     +  
Sbjct: 716 NTCAPLATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSP-----KEC 770

Query: 855 PT-DSDVSLDSEDSG-----AKSPGILGYNICPR 882
           PT DS  S  +   G     A SP  LG ++ P+
Sbjct: 771 PTEDSGASATASSKGTLTYLADSPSPLGVSVSPQ 804


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score =  107 bits (267), Expect = 5e-23
 Identities = 175/654 (26%), Positives = 238/654 (36%), Gaps = 94/654 (14%)

Query: 268 KAPAPQPPSL----PDRSPRPQRHIMSRSPMV--ERRMMGQRSPASERRPLGNFTAP--- 318
           + PA + P L    P  SPRP   +   +  V      +G++  A     +G  T P   
Sbjct: 15  RTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESA 74

Query: 319 PTYTETLSTAPLASW--VRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGS 376
           P    T ++ P AS    R+PP+ +    S  P SS   G+A   ++ G L     ++G 
Sbjct: 75  PRAGPTRTSRPPASGRGERAPPAKNT---SPGPVSS--PGRASGTTRPGPL----GQKGL 125

Query: 377 RKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQ---QE 433
           R S    V + K T  P    L   A   RR       G      A  + A+  +     
Sbjct: 126 RISAEETVARGKATEAPKRSALSAGA---RRDTSGPTPGTPSPAMARRSRAAGTEVGLPR 182

Query: 434 PAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEK 493
           PAP  R  P             + S    +  +P P      ++G G +  A R      
Sbjct: 183 PAPSARPRPPTEGP-----RKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSL---- 233

Query: 494 YVIESSSHTP--ELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPP---ASLYHGY 548
               SSS TP    AR        P +  +P+        A R P  TPP   A+   G 
Sbjct: 234 ----SSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGP 289

Query: 549 LPENGVLRPEPTKQPPYQLRPSLFVLS--PIKEPAKVSPRAASPAKPSSLDLVPNLPKGA 606
           L  + +  P P+  P     PSL  L   P   P++ +    SP   ++   +P+ P   
Sbjct: 290 LSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSP 349

Query: 607 LPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQA---PR 663
           L   P    P+ + P L   P          SPP    +SP++     +P A        
Sbjct: 350 LATPPPQAPPALALPPLQAPP----------SPPASPPLSPLATPSPQAPNALAVHLLQA 399

Query: 664 PSFSTRNAGIEAQDRRESLPTSPPWTPGASRP---PSSLDG---WVSPGPWEPGRGSSMS 717
           P     +  ++A     S P SPP +P A+ P   P SL      V P P      S  +
Sbjct: 400 PFSPPPSPPVQAPF---SPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSA 456

Query: 718 SPPPLPPPPPMSPSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGA 777
           +PPP  PPP  +P        P  P   A PP   LQAL              SP  A  
Sbjct: 457 TPPPQAPPPLAAPPLQLAKPPPQAPPALATPP---LQAL-------------PSP-PASF 499

Query: 778 ENPRPFSPPRAPPPPP---PPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSS 834
               PFSP  + P  P   PPP  PP + +P    P S        AP  R P P   +S
Sbjct: 500 PGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAP-RRPPTPGPDTS 558

Query: 835 CTSPRSPL---PAPPRPFLYRRSPTDSDVSLDSEDSGAKS--PGILGYNICPRG 883
            + PR  L   P PP P     S T S   L    S A S    + GY+  P G
Sbjct: 559 VSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEG 612



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 162/695 (23%), Positives = 226/695 (32%), Gaps = 107/695 (15%)

Query: 179 SSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPT--------KVYSEVHFTLA 230
           +SRPPAS     +      P            GRA+ TT          ++ +E      
Sbjct: 82  TSRPPASGRGERA-----PPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARG 136

Query: 231 KPPSVVNRTARPFGIQAP-GGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIM 289
           K      R+A   G +    G +    SP + RR          P   P   PRP     
Sbjct: 137 KATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGP 196

Query: 290 SRS-PMVERRMMGQRSPASERRPL--GNFTAPPTYTETLSTAPLASWVRSPPSY-----S 341
            +S          + SPA+ RRP   G    P + + + S  PL+S  RS PS      +
Sbjct: 197 RKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRA 256

Query: 342 VLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQT 401
             +PS  PK   L+    P       + +  R+ +  ++      P  TP+P        
Sbjct: 257 PAHPSQ-PKPKGLQALRPP-------QVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSA 308

Query: 402 ADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRI 461
               +           +   +LG+          P    SP A     P+    L  P +
Sbjct: 309 PPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPP--PQAPPALALPPL 366

Query: 462 QAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKY 521
           QA P P  +  LS  +    +      + +  +++++    P     PSP +  P S   
Sbjct: 367 QAPPSPPASPPLSPLATPSPQA----PNALAVHLLQAPFSPP-----PSPPVQAPFS--- 414

Query: 522 PTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPA 581
           P  +P        SP+ TPP+              P     PP Q+ PS     P+   A
Sbjct: 415 PPASPPV------SPSATPPSQA------------PPSLAAPPLQVPPSPPASPPMSPSA 456

Query: 582 KVSPRAASPAKPSSLDLVPNLPKG----ALPPSPALPRPSRSSPGL--YTSPGQDSLQPT 635
              P+A  P     L L    P+     A PP  ALP P  S PG   ++      + P 
Sbjct: 457 TPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPL 516

Query: 636 AVSPPYG-----GDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTP 690
           A  PP         +  V PS   SP  +   RP     +  +       +L   PP  P
Sbjct: 517 ATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPP--P 574

Query: 691 GASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPPPMSPSWSERSVSPLRPETEARPPS 750
             SR PSS       GP   G  SS +S P         P     +  P   E  A  P+
Sbjct: 575 PPSRSPSS----TLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPA 630

Query: 751 RQLQALLARNIINAARRKSASPRS-AGAEN-PRPFSPPRAPP-------------PPPPP 795
                        A  R  A P +  GA   P P+ P   P              P    
Sbjct: 631 -------------AWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESAT 677

Query: 796 PPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPA 830
           P P      P P   G  A  GA      RSP  A
Sbjct: 678 PAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQA 712



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 89/332 (26%), Positives = 116/332 (34%), Gaps = 80/332 (24%)

Query: 578 KEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAV 637
           ++ AK    A +PA  +   L P  P    PP P  P   R   G   + G+  L   A 
Sbjct: 5   RDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVL-GAAGAVGRKPLAERAG 63

Query: 638 SPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPS 697
               GG   P S  RA   R  + P            A  R E  P +   +PG    P 
Sbjct: 64  G--IGGATIPESAPRAGPTRTSRPP------------ASGRGERAPPAKNTSPGPVSSPG 109

Query: 698 SLDGWVSPGPW-----------EPGRGSSMSSPPPL------------PPPPPMSPSWSE 734
              G   PGP               RG +  +P               P P   SP+ + 
Sbjct: 110 RASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMAR 169

Query: 735 RS------VSPLRPETEARP------PSRQLQALLARNIIN---AARRK----------- 768
           RS      V   RP   ARP      P + + +    +      AARR+           
Sbjct: 170 RSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPA 229

Query: 769 ------SASPRSAGAEN-PRPFSPPRAPPPPPPPPPPP-PRMRSPQPARPGSAAVPGAAF 820
                 SA+P S+ A + P     PRAP  P  P P     +R PQ   P   A P  A 
Sbjct: 230 SRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAP--AL 287

Query: 821 APIPRSPL----PAGPSSCTSPRS--PLPAPP 846
            P+  SPL    P+ P S ++P S   LP+PP
Sbjct: 288 GPLSSSPLATPSPSAPPSPSAPPSLQTLPSPP 319



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 73/316 (23%), Positives = 104/316 (32%), Gaps = 39/316 (12%)

Query: 50  AQQSSPAPP------PAEVHSPAADVNQNL----ASPSATLTTPTSNSSHNPPATDVNQN 99
           A  S P P       P +V  P  D    L    +SP AT +     S   PP+     +
Sbjct: 258 AHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPS 317

Query: 100 PPATVVPQ-SLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLID 158
           PPAT   Q +  L S    ++ + LPS    P + P        PQAP        L + 
Sbjct: 318 PPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATP-------PPQAP------PALALP 364

Query: 159 KVSTPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTP 218
            +  P +  ++        PS + P +  +         P +  V A          +  
Sbjct: 365 PLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPS 424

Query: 219 TKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQ-PPSL 277
               S+   +LA PP  V  +       +P  T   +  P L         P PQ PP+L
Sbjct: 425 ATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPAL 484

Query: 278 P----DRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASW 333
                   P P      ++P          SP S   P+     PP     +  APL   
Sbjct: 485 ATPPLQALPSPPASFPGQAPF---------SP-SASLPMSPLATPPPQAPPVLAAPLLQV 534

Query: 334 VRSPPSYSVLYPSSDP 349
             SPP+   L     P
Sbjct: 535 PPSPPASPTLQAPRRP 550



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 36/115 (31%), Positives = 46/115 (40%), Gaps = 8/115 (6%)

Query: 765 ARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQPA---RPGSAAVPGAAFA 821
           A  ++ + R+ G   PRP   PR   PPPP  P   R+     A   +P +    G   A
Sbjct: 12  AAARTPAARAPGLLTPRPPGSPR---PPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGA 68

Query: 822 PIPRSPLPAGPSSCTSPRSPLPAPPRPFLYRRSPTDSDVSLDSEDSGAKSPGILG 876
            IP S   AGP+  + P +       P     SP    VS     SG   PG LG
Sbjct: 69  TIPESAPRAGPTRTSRPPASGRGERAPPAKNTSP--GPVSSPGRASGTTRPGPLG 121


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score =  104 bits (260), Expect = 3e-22
 Identities = 183/767 (23%), Positives = 268/767 (34%), Gaps = 118/767 (15%)

Query: 163 PATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPT--- 219
           P  +  T SR     P+SRPPAS     +      P            GRA+ TT     
Sbjct: 79  PTRSAGTSSRN----PASRPPASGRGERA-----PPAKNTSPGPVSSPGRASGTTRPGPL 129

Query: 220 -----KVYSEVHFTLAKPPSVVNRTARPFGIQAP-GGTSQMERSPMLERRHFGEKAPAPQ 273
                ++ +E      K      R+A   G +    G +    SP + RR          
Sbjct: 130 GQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGL 189

Query: 274 PPSLPDRSPRPQRHIMSRS-PMVERRMMGQRSPASERRPL--GNFTAPPTYTETLSTAPL 330
           P   P   PRP      +S          + SPA+ RRP   G    P + + + S  PL
Sbjct: 190 PRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPL 249

Query: 331 ASWVRSPPSY-----SVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVE 385
           +S  RS PS      +  +PS  PK   L+    P       + +  R+ +  ++     
Sbjct: 250 SSPARSGPSARGTPRAPAHPSQ-PKPKGLQALRPP-------QVTPPRKDAAPALGPLSS 301

Query: 386 KPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEAS--------NFQQEPAPR 437
            P  TP+P                          P A     +        + Q  P+P 
Sbjct: 302 SPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPP 361

Query: 438 --------------DRASPAAAEEVVP-EWASCLKSPRIQAKPKPKPNQNLSEASGKGAE 482
                            +P + + + P +    L SP +QA P P    +L   +  G+ 
Sbjct: 362 ATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSP 421

Query: 483 LYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVA-----SRSPA 537
                 S    ++  S   T      PS   S P     P  AP +   +     S SPA
Sbjct: 422 TLQATHS----FLTMSPRQTQASLTSPSRPASTPPD-SPPLQAPLSLPASPPLQTSLSPA 476

Query: 538 RTPPAS--LYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSS 595
            +P +S    H     + +    P       + P L   S +  P+  +P A+    P  
Sbjct: 477 VSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPP-- 534

Query: 596 LDLVPNL--------------PKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPY 641
           L+ +P+L              P    PP PA P P ++ P   T+P  ++  P++++ P 
Sbjct: 535 LENLPSLAPPPLQTASAPLTTPHLETPPCPA-PCPLQAPPSPLTTPPPET--PSSIATP- 590

Query: 642 GGDISPVSPSRAWSPRAKQAPRPSFST-RNAGIEAQDRRESLPTSPPWTPGASRPPSSLD 700
                P +P    SP  +  P P  S       +A       P   P +P AS P S L 
Sbjct: 591 ----PPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPL- 645

Query: 701 GWVSPGPWEPGRGSS--MSSPPPLPPPPPMSPSWSERSVSPLRPETEARPPSRQLQALLA 758
              +P P  P   +   + +P   PP PP+   +S  +  P+ P   A PPS Q    LA
Sbjct: 646 --ATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPS--ATPPS-QAPPSLA 700

Query: 759 RNIINAARRKSASPRSAGAENPRPFSPP--RAP----PPPPPPPPPPPRMRSPQPARPGS 812
              +       ASP  + +  P P +PP   AP    PP PP  PP     +P P  P  
Sbjct: 701 APPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPL 760

Query: 813 AAVPGAAFAPIPRSPLP----------AGPSSCTSPRSPLPAPPRPF 849
            A P     P P + LP          A P+  T P   LP+PP  F
Sbjct: 761 LAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASF 807



 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 213/887 (24%), Positives = 298/887 (33%), Gaps = 131/887 (14%)

Query: 58  PPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQN 117
           PPA+  SP    +   AS   T   P         A +      AT  P+   LS+  + 
Sbjct: 104 PPAKNTSPGPVSSPGRAS-GTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARR 162

Query: 118 SSEAQLPSNGTGPASKPSTLCAD--GQPQ-APAEEVRCSTLLIDKVSTPATTTSTFSREA 174
            +    P   +   ++ S       G P+ AP+   R  T        P  + S+ S  +
Sbjct: 163 DTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPT------EGPRKSVSSASEHS 216

Query: 175 TLIPSS----RPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLA 230
           T  PS     RP A   +       +  +   +S+    SG +A  TP    +  H +  
Sbjct: 217 TTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPAR-SGPSARGTPR---APAHPSQP 272

Query: 231 KPPSVVNRTARPFGIQAPG-----GTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQ 285
           KP  +  +  RP  +  P          +  SP+      G KA  P PP  PD +  P 
Sbjct: 273 KPKGL--QALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKA-RPVPP--PDNAATPL 327

Query: 286 RHIMSRSPMVERRM-----MGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSY 340
              +  SP +   +          P+ +  P    T P     +++T P+    ++PPS 
Sbjct: 328 PATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPM----QAPPSL 383

Query: 341 SVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQ 400
             + P   P S        P S   +         S     T +  P +      L +  
Sbjct: 384 QTIPPIQVPHSLTSPSLQAPPSPLAL---------SSLQATTSLGSPTLQATHSFLTMSP 434

Query: 401 TADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDR-ASPAAAEEVVPEWASCLKSP 459
                  ++ Q  +     P +   ++   Q   AP    ASP     + P   S L SP
Sbjct: 435 -------RQTQASLTSPSRPASTPPDSPPLQ---APLSLPASPPLQTSLSPA-VSPLSSP 483

Query: 460 RIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSW 519
                    P Q LS  +    +  A   S +   +   SS  P   + P  +++ P   
Sbjct: 484 LTI-----HPLQALSSLASHSPQ--APLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLE 536

Query: 520 KYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKE 579
             P+ AP   + AS +P  TP         P      P P   PP +   S+    P   
Sbjct: 537 NLPSLAPPPLQTAS-APLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAP 595

Query: 580 PAKVSPRAASPAKPSSLDLVPNLPKG----ALPPSPALPRPSRSSPGLYTSPGQDSLQPT 635
           PA  SP       P    L    P+     ALPP  A P P  S P          L P 
Sbjct: 596 PALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPP----------LSPL 645

Query: 636 AVSPPYGGDISPVSPSRA-WSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASR 694
           A   P   +   V   +A +SP      +  FS             S P SP  TP +  
Sbjct: 646 ATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPP----------ASPPVSPSATPPSQA 695

Query: 695 PPS----SLDGWVSPGPWEPGRGSSMSSPPPLPPP-----------PPMSPSWSERSVSP 739
           PPS     L    SP P  P    S + PP  PPP           PP SP  S  +  P
Sbjct: 696 PPSLAAPPLQVPPSP-PASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPP 754

Query: 740 LRP---------ETEARPPSRQLQALLARNIINAARRKSASPRSAGAENP------RPFS 784
            R          +    PP+    + LA+    A    +  P  A    P       PFS
Sbjct: 755 PRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFS 814

Query: 785 PPRAPPPPP---PPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCTSPRSP 841
           P  + P  P   PPP  PP + +P    P S        AP  R P P   +S + PR  
Sbjct: 815 PSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAP-RRPPTPGPDTSVSGPRLT 873

Query: 842 L---PAPPRPFLYRRSPTDSDVSLDSEDSGAKS--PGILGYNICPRG 883
           L   P PP P     S T S   L    S A S    + GY+  P G
Sbjct: 874 LALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEG 920



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 214/871 (24%), Positives = 301/871 (34%), Gaps = 128/871 (14%)

Query: 39  ANGLHLSQNREAQQSSPAPP---PAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATD 95
           A G  +   R A  + P PP   P +  S A++ +    SP+A            P +  
Sbjct: 182 AAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRS 241

Query: 96  VNQNPPATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTL 155
           ++    ++  P S P  S        + P++ + P  KP  L A   PQ        +  
Sbjct: 242 LS----SSATPLSSPARSGPSARGTPRAPAHPSQP--KPKGLQALRPPQVTPPRKDAAPA 295

Query: 156 LIDKVSTPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAA 215
           L    S+P  T S    +A  +P   PP  D  ++ L     P TL  S         A 
Sbjct: 296 LGPLSSSPLATPSPSGTKARPVP---PP--DNAATPL-----PATLPPSPPLATPLPLAP 345

Query: 216 TTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAP-GGTSQMERSPMLERRHFGEKAPAPQP 274
            +P+   S    TL  PP+     A P     P      ++  P ++  H    +P+ Q 
Sbjct: 346 PSPSAPPSLQ--TLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPH-SLTSPSLQA 402

Query: 275 PSLPDRSPRPQRHIMSRSPMVERR-----MMGQRSPASERRPLGNFTAPPTYTETLSTAP 329
           P  P      Q      SP ++       M  +++ AS   P    + PP        AP
Sbjct: 403 PPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPL--QAP 460

Query: 330 LASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKV 389
           L S   SPP  + L P+  P SS L    + A        S+A    +  + + +  P  
Sbjct: 461 L-SLPASPPLQTSLSPAVSPLSSPLTIHPLQALS------SLASHSPQAPLSSLIMPPLE 513

Query: 390 TPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEAS---------------NFQQEP 434
           T +      +QT            +     P    A A                  Q  P
Sbjct: 514 TQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPP 573

Query: 435 APRDRASPAAAEEVV---PEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRM 491
           +P     P     +    P+    L SP +Q  P P P   L+    +     A      
Sbjct: 574 SPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSP-PLSPLATPPPQAPPXLA------ 626

Query: 492 EKYVIESSSHTPELARCPSPTMSLP-SSWKYPT-NAPGAFRV----ASRSPARTPPASLY 545
                      P L   PSP  S P S    P+  AP A  V    A  SP  +PP    
Sbjct: 627 ----------LPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQA- 675

Query: 546 HGYLPENGVLRP--EPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLP 603
               P +    P   P+  PP Q  PSL    P++ P   SP A+ P  PS+       P
Sbjct: 676 ----PFSPPASPPVSPSATPPSQAPPSL-AAPPLQVPP--SPPASPPMSPSATPPPQAPP 728

Query: 604 KGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPR 663
             A PP    P P  S P   ++     + P   +PP     SP + S   SP AK  P+
Sbjct: 729 PLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPA-SLPMSPLAKPPPQ 787

Query: 664 PSFSTRNAGIEA-QDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPP-P 721
              +     ++A      S P   P++P AS P S L    +P P  P     +++P   
Sbjct: 788 APPALATPPLQALPSPPASFPGQAPFSPSASLPMSPL---ATPPPQAP---PVLAAPLLQ 841

Query: 722 LPPPPPMSPSWSERSVSPLRPETEARPPS---RQLQALLARNIINAARRKSAS----PRS 774
           +PP PP SP+      +P RP T     S    +L   LA        R  +S    P  
Sbjct: 842 VPPSPPASPTLQ----APRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDL 897

Query: 775 AGAENPRPFSPPRAPPPPPPP-------PPPPPRMRSPQPARPGSAAVPGAAFAPIPRSP 827
           AG  +    +P         P       PPP   + +  PA       P  AF   P +P
Sbjct: 898 AGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAP 957

Query: 828 LP----AGPSS----CT-----SPRSPLPAP 845
           LP     GP S    CT      P S  PAP
Sbjct: 958 LPWPPATGPGSADGLCTIYETEGPESATPAP 988



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 199/850 (23%), Positives = 273/850 (32%), Gaps = 177/850 (20%)

Query: 48   REAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPT---SNSSHNPPATDVNQNPPATV 104
            R  Q + P    A    P +       SPS T   P     N++   PAT     P AT 
Sbjct: 281  RPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATP 340

Query: 105  VPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPA 164
            +P + P  S     S   LPS    P S+          QAP      S   I  +  P 
Sbjct: 341  LPLAPPSPSAPP--SLQTLPSPPATPPSQAPPSMTTPPMQAPP-----SLQTIPPIQVPH 393

Query: 165  TTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSE 224
            + TS         PS + P S    SSL    Q  T + S   + +      +P +  ++
Sbjct: 394  SLTS---------PSLQAPPSPLALSSL----QATTSLGSPTLQATHSFLTMSPRQ--TQ 438

Query: 225  VHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQP---------P 275
               T    P+     + P  +QAP     +  SP L+       +P   P          
Sbjct: 439  ASLTSPSRPASTPPDSPP--LQAP---LSLPASPPLQTSLSPAVSPLSSPLTIHPLQALS 493

Query: 276  SLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETL-STAPLASWV 334
            SL   SP+     +   P+  +  +   +P S + P  + T PP   E L S AP     
Sbjct: 494  SLASHSPQAPLSSLIMPPLETQSSL---APPSLQTPPASLTTPPL--ENLPSLAP----- 543

Query: 335  RSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPD 394
              PP  +   P + P   HL+    PA                         P  TP P+
Sbjct: 544  --PPLQTASAPLTTP---HLETPPCPAP----------------CPLQAPPSPLTTPPPE 582

Query: 395  LLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWAS 454
                + T                + P AL +        P     A+P       P+   
Sbjct: 583  TPSSIATPPP-------------QAPPALASPPLQGLPSPPLSPLATPP------PQAPP 623

Query: 455  CLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMS 514
             L  P +QA P P  +  LS  +    +      + +  +++++    P     PSP + 
Sbjct: 624  XLALPPLQAPPSPPASPPLSPLATPSPQA----PNALAVHLLQAPFSPP-----PSPPVQ 674

Query: 515  LP----------SSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPP 564
             P           S   P+ AP +          +PPAS             P P   PP
Sbjct: 675  APFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPP 734

Query: 565  YQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLY 624
             Q+ PS    SP   P+   P    P   +    VP  P  +LP SP    P ++ P L 
Sbjct: 735  LQVPPSP-PASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALA 793

Query: 625  TSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPT 684
            T P Q    P A  P      +P SPS +        P P      A    Q     +P 
Sbjct: 794  TPPLQALPSPPASFPGQ----APFSPSASLPMSPLATPPPQAPPVLAAPLLQ-----VPP 844

Query: 685  SPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSP-------PPLPPPPPMSPSWS---- 733
            SPP +P    P           P  PG  +S+S P       P  PPPP  SPS +    
Sbjct: 845  SPPASPTLQAPRR---------PPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGP 895

Query: 734  ----ERSVSPLRPE-------------TEARPPSRQLQALLARNIINAARRKSASPRSA- 775
                  S +   PE               + PP  +L A        AA  +  +P  A 
Sbjct: 896  DLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHP-----AAWSRGPAPPLAF 950

Query: 776  -GAEN-PRPFSPPRAPP-------------PPPPPPPPPPRMRSPQPARPGSAAVPGAAF 820
             GA   P P+ P   P              P    P P      P P   G  A  GA  
Sbjct: 951  RGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGA 1010

Query: 821  APIPRSPLPA 830
                RSP  A
Sbjct: 1011 GASSRSPKQA 1020



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 112/429 (26%), Positives = 155/429 (36%), Gaps = 44/429 (10%)

Query: 437 RDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVI 496
           RD+A   AA       A  L +PR    P+P P    +     GA     R+   E+   
Sbjct: 5   RDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGG 64

Query: 497 ESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRS-PARTPPASLYHGYLPENGVL 555
              +  PE A    PT S  +S + P + P A     R+ PA+             +G  
Sbjct: 65  IGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTT 124

Query: 556 RPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPR 615
           RP P  Q   ++     V    +  A  +P+ ++ +  +  D     P     PSPA+ R
Sbjct: 125 RPGPLGQKGLRISAEETV---ARGKATEAPKRSALSAGARRDTSGPTPG---TPSPAMAR 178

Query: 616 PSRSSPGLYTSPGQDSLQPTA-VSPPYGG---DISPVSPSRAWSPRAKQAPRPSFSTRNA 671
            SR++    T  G     P+A   PP  G    +S  S      P      RPS      
Sbjct: 179 RSRAAG---TEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPS---AGG 232

Query: 672 GIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPG-PWEP-GRGSSMSSPPPLPPP---- 725
           G++    R    ++ P +  A   PS+     +P  P +P  +G     PP + PP    
Sbjct: 233 GLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDA 292

Query: 726 -PPMSPSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFS 784
            P + P  S    +P    T+ARP      A        A    +  P S     P P +
Sbjct: 293 APALGPLSSSPLATPSPSGTKARPVPPPDNA--------ATPLPATLPPSPPLATPLPLA 344

Query: 785 PPRAPPPP-----PPPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCTSPR 839
           PP    PP     P PP  PP    P    P   A P     P    P+   P S TSP 
Sbjct: 345 PPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIP----PIQV-PHSLTSP- 398

Query: 840 SPLPAPPRP 848
             L APP P
Sbjct: 399 -SLQAPPSP 406



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 41/122 (33%), Positives = 52/122 (42%), Gaps = 13/122 (10%)

Query: 765 ARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQPA---RPGSAAVPGAAFA 821
           A  ++ + R+ G   PRP   PR   PPPP  P   R+     A   +P +    G   A
Sbjct: 12  AAARTPAARAPGLLTPRPPGSPR---PPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGA 68

Query: 822 PIPRSPLPAGP--SSCTSPRSPLPAPPRPFLYRRSP-----TDSDVSLDSEDSGAKSPGI 874
            IP S   AGP  S+ TS R+P   PP      R+P     +   VS     SG   PG 
Sbjct: 69  TIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGP 128

Query: 875 LG 876
           LG
Sbjct: 129 LG 130


>gi|193083191 synaptopodin 2 isoform c [Homo sapiens]
          Length = 1109

 Score =  101 bits (252), Expect = 3e-21
 Identities = 131/494 (26%), Positives = 193/494 (39%), Gaps = 139/494 (28%)

Query: 311  PLGNFTAPPTYTETLS---------TAPLASWVRSPP-------SYSVLYPSSDPKSSHL 354
            P+ +F APP Y+             ++P+A   + PP       S    Y SS+  +S  
Sbjct: 612  PIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAFYDSSERIASRD 671

Query: 355  KGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEV 414
            +  +VPA +TGIL+E+  RR + K MFTF E PKV+PNP+LL L+Q ++ KR     G+ 
Sbjct: 672  ERISVPAKRTGILQEAK-RRSTTKPMFTFKE-PKVSPNPELLSLLQNSEGKRGTGAGGDS 729

Query: 415  GVEEEPFALGAEASNFQQEPAPRDRASPAAAEE-------------VVPEWASCLKSPRI 461
            G EE+  +LGAEA NF Q  + + +  P  A +             V P W+  +   + 
Sbjct: 730  GPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQP 789

Query: 462  QAKPKPKPNQNLSEASGKGAELY---ARRQSRME--------KYVIESSSHTPELARCPS 510
             A P   P++    +S K A+     AR  S +         +  + S ++TP+      
Sbjct: 790  PAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPK------ 843

Query: 511  PTMSLPSSWKYPTNAPG------------------------------------AFRVASR 534
            PT+S P+       A G                                    A R  S 
Sbjct: 844  PTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSP 903

Query: 535  SPA-----------RTPPASLY---HGYLPENGVLRPEPTKQPP---------------- 564
            +P+           R PP   Y   H        L+ +P+   P                
Sbjct: 904  TPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALD 963

Query: 565  ------YQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPA------ 612
                  YQL  SLF   P  +     P+ +S    S+L +     K ALPP P       
Sbjct: 964  VMKHQPYQLNASLFTFQP-PDAKDGLPQKSSVKVNSALAM-----KQALPPRPVNAASPT 1017

Query: 613  -LPRPSRSSPGLYTSPGQ---DSLQPTAVSP-PYGGDISPVSPSRAWSPRAKQAPRPSFS 667
             +   S  S   YTSP     ++  P + SP P G   SP   S + S     APRP FS
Sbjct: 1018 NVQASSVYSVPAYTSPPSFFAEASSPVSASPVPVGIPTSPKQESASSSYFV--APRPKFS 1075

Query: 668  TRNAGIEAQDRRES 681
             + +G+  Q + +S
Sbjct: 1076 AKKSGVTIQVKCKS 1089



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 100/476 (21%), Positives = 162/476 (34%), Gaps = 91/476 (19%)

Query: 473 LSEASGKGAELYARRQSRMEKYVIESSSH----TPELARCPSPTMSLPSSWKYPTNAPGA 528
           L + +GKGA ++A+R+ RM++   +        TP   +  + T  L ++  Y      +
Sbjct: 484 LPDTTGKGALMFAKRRERMDQITAQKEEDKVGGTPSREQDAAQTDGLRTTTSYQRKEEES 543

Query: 529 FRV----------ASRSPARTPPASLYHG---------YLPENGVLRPEP--TKQPPYQL 567
            R            S      P  + + G          +P N   +P P    QP    
Sbjct: 544 VRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANIQRMVPMNRTAKPFPGSVNQPATPF 603

Query: 568 RPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSR-SSPGLYTS 626
            P+  + SPI +     P +A    P +     + P       P  P+P+  S P  Y S
Sbjct: 604 SPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAFYDS 663

Query: 627 PGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSP 686
             + + +   +S P                + +   +P F+ +   +       SL  + 
Sbjct: 664 SERIASRDERISVP------AKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNS 717

Query: 687 PWT--PGASRPPSSLDGWVSPGP----WEPGRGSSMSSPPPLPPPP-----------PMS 729
                 GA       + ++S G     +     +   +PPP+ P P           P+S
Sbjct: 718 EGKRGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVS 777

Query: 730 PSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAEN-PRPFSPPRA 788
           P WS   V+P +P   A P S   +  +  + I  A+      R A   N   PF  P+A
Sbjct: 778 PVWSP-GVAPTQP--PAFPTSNPSKGTVVSS-IKIAQPSYPPARPASTLNVAGPFKGPQA 833

Query: 789 PPP----PPPPPPPPPRMRSPQPARPG-SAAVPG-------------------------- 817
                   P P    P + + QP   G S  +PG                          
Sbjct: 834 AVASQNYTPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTV 893

Query: 818 ---AAFAPIPRSPLPAGPSSCTSPRSPLPAPPRPFLYRRSPTDSDVSLDSEDSGAK 870
              AA A  P   LPA     ++ R+P P    P     SP+    +L S+ S A+
Sbjct: 894 QAHAARAQSPTPSLPASWKYSSNVRAPPPVAYNPI---HSPSYPLAALKSQPSAAQ 946


>gi|193083185 synaptopodin 2 isoform b [Homo sapiens]
          Length = 1093

 Score =  101 bits (251), Expect = 4e-21
 Identities = 130/489 (26%), Positives = 190/489 (38%), Gaps = 139/489 (28%)

Query: 311  PLGNFTAPPTYTETLS---------TAPLASWVRSPP-------SYSVLYPSSDPKSSHL 354
            P+ +F APP Y+             ++P+A   + PP       S    Y SS+  +S  
Sbjct: 612  PIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAFYDSSERIASRD 671

Query: 355  KGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEV 414
            +  +VPA +TGIL+E+  RR + K MFTF E PKV+PNP+LL L+Q ++ KR     G+ 
Sbjct: 672  ERISVPAKRTGILQEAK-RRSTTKPMFTFKE-PKVSPNPELLSLLQNSEGKRGTGAGGDS 729

Query: 415  GVEEEPFALGAEASNFQQEPAPRDRASPAAAEE-------------VVPEWASCLKSPRI 461
            G EE+  +LGAEA NF Q  + + +  P  A +             V P W+  +   + 
Sbjct: 730  GPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQP 789

Query: 462  QAKPKPKPNQNLSEASGKGAELY---ARRQSRME--------KYVIESSSHTPELARCPS 510
             A P   P++    +S K A+     AR  S +         +  + S ++TP+      
Sbjct: 790  PAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPK------ 843

Query: 511  PTMSLPSSWKYPTNAPG------------------------------------AFRVASR 534
            PT+S P+       A G                                    A R  S 
Sbjct: 844  PTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSP 903

Query: 535  SPA-----------RTPPASLY---HGYLPENGVLRPEPTKQPP---------------- 564
            +P+           R PP   Y   H        L+ +P+   P                
Sbjct: 904  TPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALD 963

Query: 565  ------YQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPA------ 612
                  YQL  SLF   P  +     P+ +S    S+L +     K ALPP P       
Sbjct: 964  VMKHQPYQLNASLFTFQP-PDAKDGLPQKSSVKVNSALAM-----KQALPPRPVNAASPT 1017

Query: 613  -LPRPSRSSPGLYTSPGQ---DSLQPTAVSP-PYGGDISPVSPSRAWSPRAKQAPRPSFS 667
             +   S  S   YTSP     ++  P + SP P G   SP   S + S     APRP FS
Sbjct: 1018 NVQASSVYSVPAYTSPPSFFAEASSPVSASPVPVGIPTSPKQESASSSYFV--APRPKFS 1075

Query: 668  TRNAGIEAQ 676
             + +G+  Q
Sbjct: 1076 AKKSGVTIQ 1084



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 100/476 (21%), Positives = 162/476 (34%), Gaps = 91/476 (19%)

Query: 473 LSEASGKGAELYARRQSRMEKYVIESSSH----TPELARCPSPTMSLPSSWKYPTNAPGA 528
           L + +GKGA ++A+R+ RM++   +        TP   +  + T  L ++  Y      +
Sbjct: 484 LPDTTGKGALMFAKRRERMDQITAQKEEDKVGGTPSREQDAAQTDGLRTTTSYQRKEEES 543

Query: 529 FRV----------ASRSPARTPPASLYHG---------YLPENGVLRPEP--TKQPPYQL 567
            R            S      P  + + G          +P N   +P P    QP    
Sbjct: 544 VRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANIQRMVPMNRTAKPFPGSVNQPATPF 603

Query: 568 RPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSR-SSPGLYTS 626
            P+  + SPI +     P +A    P +     + P       P  P+P+  S P  Y S
Sbjct: 604 SPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAFYDS 663

Query: 627 PGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSP 686
             + + +   +S P                + +   +P F+ +   +       SL  + 
Sbjct: 664 SERIASRDERISVP------AKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNS 717

Query: 687 PWT--PGASRPPSSLDGWVSPGP----WEPGRGSSMSSPPPLPPPP-----------PMS 729
                 GA       + ++S G     +     +   +PPP+ P P           P+S
Sbjct: 718 EGKRGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVS 777

Query: 730 PSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAEN-PRPFSPPRA 788
           P WS   V+P +P   A P S   +  +  + I  A+      R A   N   PF  P+A
Sbjct: 778 PVWSP-GVAPTQP--PAFPTSNPSKGTVVSS-IKIAQPSYPPARPASTLNVAGPFKGPQA 833

Query: 789 PPP----PPPPPPPPPRMRSPQPARPG-SAAVPG-------------------------- 817
                   P P    P + + QP   G S  +PG                          
Sbjct: 834 AVASQNYTPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTV 893

Query: 818 ---AAFAPIPRSPLPAGPSSCTSPRSPLPAPPRPFLYRRSPTDSDVSLDSEDSGAK 870
              AA A  P   LPA     ++ R+P P    P     SP+    +L S+ S A+
Sbjct: 894 QAHAARAQSPTPSLPASWKYSSNVRAPPPVAYNPI---HSPSYPLAALKSQPSAAQ 946


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 174/686 (25%), Positives = 240/686 (34%), Gaps = 101/686 (14%)

Query: 231 KPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHF--GEKAPAPQPPSLPDRSP-RPQRH 287
           +PP  V     P  ++  G    + R P+ ER     G   P   P + P RS     R+
Sbjct: 34  RPPPPVT----PAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRN 89

Query: 288 IMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASW---VRSPPSYSVLY 344
             SR P   R   G+R+P ++    G  ++P   + T    PL      + +  + +   
Sbjct: 90  PASRPPASGR---GERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGK 146

Query: 345 PSSDPKSSHLKGQA---VPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQT 401
            +  PK S L   A         G    +MARR   ++  T V  P+  P P       T
Sbjct: 147 ATEAPKRSALSAGARRDTSGPTPGTPSPAMARRS--RAAGTEVGLPR--PAPSARPRPPT 202

Query: 402 ADEKRRQRDQGEVGVEEEPFALGAE--ASNFQQEPAPRDRASPA----AAEEVVPEWASC 455
              ++      E    E   A      A    Q PA R  +S A    +     P     
Sbjct: 203 EGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGT 262

Query: 456 LKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSL 515
            ++P   ++PKPK  Q L                R  +         P L    S  ++ 
Sbjct: 263 PRAPAHPSQPKPKGLQAL----------------RPPQVTPPRKDAAPALGPLSSSPLAT 306

Query: 516 PS-SWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVL 574
           PS S    + AP         PA    +SL         +  P P+  P  Q  PS    
Sbjct: 307 PSPSAALQSQAPPTL------PATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPS---- 356

Query: 575 SPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQP 634
            P   P++ +    SP   ++   +P+ P   L   P    P+ + P L   P       
Sbjct: 357 PPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPP------- 409

Query: 635 TAVSPPYGGDISPVSPSRAWSPRAKQA---PRPSFSTRNAGIEAQDRRESLPTSPPWTPG 691
              SPP    +SP++     +P A        P     +  ++A     S P SPP +P 
Sbjct: 410 ---SPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPF---SPPASPPVSPS 463

Query: 692 ASRP---PSSLDG---WVSPGPWEPGRGSSMSSPPPLPPPPPMSPSWSERSVSPLRPETE 745
           A+ P   P SL      V P P      S  ++PPP  PPP  +P        P  P   
Sbjct: 464 ATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPAL 523

Query: 746 ARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPP---PPPPPPPRM 802
           A PP   LQAL              SP  A      PFSP  + P  P   PPP  PP +
Sbjct: 524 ATPP---LQAL-------------PSP-PASFPGQAPFSPSASLPMSPLATPPPQAPPVL 566

Query: 803 RSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCTSPRSPL---PAPPRPFLYRRSPTDSD 859
            +P    P S        AP  R P P   +S + PR  L   P PP P     S T S 
Sbjct: 567 AAPLLQVPPSPPASPTLQAP-RRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSG 625

Query: 860 VSLDSEDSGAKS--PGILGYNICPRG 883
             L    S A S    + GY+  P G
Sbjct: 626 PDLAGHSSSATSTPEELRGYDSGPEG 651



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 122/479 (25%), Positives = 174/479 (36%), Gaps = 80/479 (16%)

Query: 437 RDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVI 496
           RD+A   AA       A  L +PR    P+P P    +     GA     R+   E+   
Sbjct: 5   RDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGG 64

Query: 497 ESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRS-PARTPPASLYHGYLPENGVL 555
              +  PE A    PT S  +S + P + P A     R+ PA+             +G  
Sbjct: 65  IGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTT 124

Query: 556 RPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGAL-------- 607
           RP P  Q   ++     V       A      ++ A+  +    P  P  A+        
Sbjct: 125 RPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAG 184

Query: 608 -------PPSPALPRPSRSSPGLYTSPGQD--SLQPTAVS---PPYGGDI---------- 645
                  P   A PRP    P    S   +  + +P+  +   P  GG +          
Sbjct: 185 TEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSS 244

Query: 646 --SPVSPSRAWSPRAKQAPR----PSFSTRNAGIEA-------QDRRESLP------TSP 686
             +P+S      P A+  PR    PS   +  G++A         R+++ P      +SP
Sbjct: 245 SATPLSSPARSGPSARGTPRAPAHPS-QPKPKGLQALRPPQVTPPRKDAAPALGPLSSSP 303

Query: 687 PWTPGASRPPSSLDGWVSPG-PWEPGRGS---SMSSPPPLPPPPPMSPSWSERSVSPLRP 742
             TP    P ++L     P  P  P   S    +++P PL PP P +P     S+  L P
Sbjct: 304 LATPS---PSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPP----SLQTL-P 355

Query: 743 ETEARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSPP-------RAPPPPPPP 795
              A PPS Q    L    + A      SP  +    P P +PP       +APP PP  
Sbjct: 356 SPPATPPS-QATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPAS 414

Query: 796 PPPPPRMRSPQPARPGSAAVP--GAAFAPIPRSPL------PAGPSSCTSPRSPLPAPP 846
           PP  P + +P P  P + AV    A F+P P  P+      PA P    S   P  APP
Sbjct: 415 PPLSP-LATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPP 472



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 180/740 (24%), Positives = 246/740 (33%), Gaps = 139/740 (18%)

Query: 163 PATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPT--- 219
           P  +  T SR     P+SRPPAS     +      P            GRA+ TT     
Sbjct: 79  PTRSAGTSSRN----PASRPPASGRGERA-----PPAKNTSPGPVSSPGRASGTTRPGPL 129

Query: 220 -----KVYSEVHFTLAKPPSVVNRTARPFGIQAP-GGTSQMERSPMLERRHFGEKAPAPQ 273
                ++ +E      K      R+A   G +    G +    SP + RR          
Sbjct: 130 GQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGL 189

Query: 274 PPSLPDRSPRPQRHIMSRS-PMVERRMMGQRSPASERRPL--GNFTAPPTYTETLSTAPL 330
           P   P   PRP      +S          + SPA+ RRP   G    P + + + S  PL
Sbjct: 190 PRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPL 249

Query: 331 ASWVRSPPSY-----SVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVE 385
           +S  RS PS      +  +PS  PK   L+    P       + +  R+ +  ++     
Sbjct: 250 SSPARSGPSARGTPRAPAHPSQ-PKPKGLQALRPP-------QVTPPRKDAAPALGPLSS 301

Query: 386 KPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEE---PFALGAEASNFQQEPAPRDRASP 442
            P  TP+P      Q             +  +     P A  + ++    +  P   A+P
Sbjct: 302 SPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATP 361

Query: 443 AAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHT 502
            +      +  + L SP +QA     P+  LS  +    +                +   
Sbjct: 362 PS------QATTSLGSPTLQATHSFLPSPPLSPLATPPPQA-------------PPALAL 402

Query: 503 PELARCPSPTMSLP-SSWKYPT-NAPGAFRV----ASRSPARTPPASLYHGYLPENGVLR 556
           P L   PSP  S P S    P+  AP A  V    A  SP  +PP        P +    
Sbjct: 403 PPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQA-----PFSPPAS 457

Query: 557 P--EPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALP 614
           P   P+  PP Q  PSL    P++ P   SP A+ P  PS+       P  A PP     
Sbjct: 458 PPVSPSATPPSQAPPSL-AAPPLQVPP--SPPASPPMSPSATPPPQAPPPLAAPPLQLAK 514

Query: 615 RPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIE 674
            P ++ P L T P Q    P A  P      +P SPS +        P P      A   
Sbjct: 515 PPPQAPPALATPPLQALPSPPASFPGQ----APFSPSASLPMSPLATPPPQAPPVLAAPL 570

Query: 675 AQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSP-------PPLPPPPP 727
            Q     +P SPP +P    P           P  PG  +S+S P       P  PPPP 
Sbjct: 571 LQ-----VPPSPPASPTLQAPRR---------PPTPGPDTSVSGPRLTLALAPGPPPPPS 616

Query: 728 MSPSWS--------ERSVSPLRPE-------------TEARPPSRQLQALLARNIINAAR 766
            SPS +          S +   PE               + PP  +L A        AA 
Sbjct: 617 RSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHP-----AAW 671

Query: 767 RKSASPRSA--GAEN-PRPFSPPRAPP-------------PPPPPPPPPPRMRSPQPARP 810
            +  +P  A  GA   P P+ P   P              P    P P      P P   
Sbjct: 672 SRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTS 731

Query: 811 GSAAVPGAAFAPIPRSPLPA 830
           G  A  GA      RSP  A
Sbjct: 732 GGKAAAGAGAGASSRSPKQA 751



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 75/289 (25%), Positives = 104/289 (35%), Gaps = 37/289 (12%)

Query: 578 KEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAV 637
           ++ AK    A +PA  +   L P  P    PP P  P   R   G   + G+  L   A 
Sbjct: 5   RDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVL-GAAGAVGRKPLAERAG 63

Query: 638 SPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIE--AQDRRESLPTSPPWTPGASRP 695
               GG   P S     +PRA        S+RN      A  R E  P +   +PG    
Sbjct: 64  G--IGGATIPES-----APRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSS 116

Query: 696 PSSLDGWVSPGPWEPGRGSSMSSPPPLPPPPPMSPSWSERSVSPLRPETEARPPSRQLQA 755
           P    G   PGP    +G  +S+   +               +  R +T    P     A
Sbjct: 117 PGRASGTTRPGPLGQ-KGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPA 175

Query: 756 LLARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPP-----------PPPPPPPRMRS 804
           +        ARR  A+    G   P P + PR P   P              P P   R 
Sbjct: 176 M--------ARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRR 227

Query: 805 PQPA----RPGSAAVPGAAFAPIPRSPLPAGPSSCTSPRSPL-PAPPRP 848
           P       RP S ++  +A  P+  SP  +GPS+  +PR+P  P+ P+P
Sbjct: 228 PSAGGGLQRPASRSLSSSA-TPL-SSPARSGPSARGTPRAPAHPSQPKP 274



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 41/122 (33%), Positives = 52/122 (42%), Gaps = 13/122 (10%)

Query: 765 ARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQPA---RPGSAAVPGAAFA 821
           A  ++ + R+ G   PRP   PR   PPPP  P   R+     A   +P +    G   A
Sbjct: 12  AAARTPAARAPGLLTPRPPGSPR---PPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGA 68

Query: 822 PIPRSPLPAGP--SSCTSPRSPLPAPPRPFLYRRSP-----TDSDVSLDSEDSGAKSPGI 874
            IP S   AGP  S+ TS R+P   PP      R+P     +   VS     SG   PG 
Sbjct: 69  TIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGP 128

Query: 875 LG 876
           LG
Sbjct: 129 LG 130



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 73/308 (23%), Positives = 107/308 (34%), Gaps = 37/308 (12%)

Query: 50  AQQSSPAPP--PAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQ 107
           A   S APP  PA  HS  + +   LA+P   L  P+ ++   PP+     +PPAT   Q
Sbjct: 311 AALQSQAPPTLPATPHS--SSLTCQLATP-LPLAPPSPSA---PPSLQTLPSPPATPPSQ 364

Query: 108 -SLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATT 166
            +  L S    ++ + LPS    P + P        PQAP        L +  +  P + 
Sbjct: 365 ATTSLGSPTLQATHSFLPSPPLSPLATP-------PPQAP------PALALPPLQAPPSP 411

Query: 167 TSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVH 226
            ++        PS + P +  +         P +  V A          +      S+  
Sbjct: 412 PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAP 471

Query: 227 FTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQ-PPSLP----DRS 281
            +LA PP  V  +       +P  T   +  P L         P PQ PP+L        
Sbjct: 472 PSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQAL 531

Query: 282 PRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYS 341
           P P      ++P          SP S   P+     PP     +  APL     SPP+  
Sbjct: 532 PSPPASFPGQAPF---------SP-SASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASP 581

Query: 342 VLYPSSDP 349
            L     P
Sbjct: 582 TLQAPRRP 589


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
           sapiens]
          Length = 5537

 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 123/402 (30%), Positives = 145/402 (36%), Gaps = 80/402 (19%)

Query: 498 SSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVA-----------SRSPARTPPASLYH 546
           +  HTP  +R      S P     PT+ P A  VA           S  P    P     
Sbjct: 362 AEQHTPVCSR-----FSPPEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEPGPLQCEA 416

Query: 547 GYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKP----SSLDLVPN- 601
             L + GV + EP  + P  L   + +L P +E     P   SP  P    S L   P  
Sbjct: 417 KPLGKAGV-QLEPQLEAP--LNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEE 473

Query: 602 LPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGG-DISPVSPSRAWSP---- 656
           LP   LP +  L RP   SP L   P +  L P   S P+   + SP+SP     P    
Sbjct: 474 LPASPLPEALHLSRPLEESP-LSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPAL 532

Query: 657 RAKQAPRPSFSTRNAGIEAQDRR---ESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRG 713
               +P P  S  +   E        E LPTSPP  P ASR        +SP P E    
Sbjct: 533 ETPLSPPPEASPLSPPFEESPLSPPPEELPTSPP--PEASR--------LSPPPEE---- 578

Query: 714 SSMSSPP---PLPPPPPMSPSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSA 770
           S MS PP   P+ PPP  S  +     SPL P  E  P S                    
Sbjct: 579 SPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLS-------------------- 618

Query: 771 SPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPA 830
            P  A   +P P   P +PPP   P  PPP +    P    S   P     P   SPL  
Sbjct: 619 PPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSP-----PPEESPLSP 673

Query: 831 GPSSCTSPRSPLPAPPRPFLYRRSPTDSDVSLDSEDSGAKSP 872
            P    SP SP   PP        P DS  S   EDS A  P
Sbjct: 674 PPEE--SPTSP---PPEASRLSPPPEDSPTSPPPEDSPASPP 710



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 201/856 (23%), Positives = 294/856 (34%), Gaps = 213/856 (24%)

Query: 22   EEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLT 81
            EE+PL+   +E+          LS   E   +SP P  + +  P  ++  +    +  L+
Sbjct: 436  EEMPLLPPPEESP---------LSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLS 486

Query: 82   TPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADG 141
             P   S  +PP  +   +PP    P+S P S ++++            P S P     + 
Sbjct: 487  RPLEESPLSPPPEESPLSPP----PESSPFSPLEES------------PLSPP-----EE 525

Query: 142  QPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTL 201
             P +PA E   S        +P    S  S     +P+S PP +  +S        P   
Sbjct: 526  SPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRLSP------PPEES 579

Query: 202  VVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLE 261
             +S   E S  +     ++++     +   PP           +  P   S++   P   
Sbjct: 580  PMSPPPEESPMSPPPEASRLFPPFEESPLSPP------PEESPLSPPPEASRLSPPP--- 630

Query: 262  RRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLG-----NFT 316
                 E +P   PP     SP P+   +S  P+V R      SP  E  PL      + T
Sbjct: 631  -----EDSPMSPPPEESPMSPPPEVSRLSPLPVVSR-----LSPPPEESPLSPPPEESPT 680

Query: 317  APPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGIL----EESMA 372
            +PP     LS  P  S    PP  S   P+S P    L   ++P  ++ +L    E  + 
Sbjct: 681  SPPPEASRLSPPPEDSPTSPPPEDS---PASPPPEDSL--MSLPLEESPLLPLPEEPQLC 735

Query: 373  RRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGE---VGVEEEPFALGAEASN 429
             R     +    E+P ++P P+   L   A+E        E     V EEP  L  +A  
Sbjct: 736  PRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPH-LSPQAEG 794

Query: 430  FQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQS 489
                P P +       EE  P  +   + P +     P+P ++      +   L  R   
Sbjct: 795  PHLSPQPEELHLSPQTEE--PHLSPVPEEPCL----SPQPEESHLSPQSEEPCLSPRP-- 846

Query: 490  RMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYL 549
                   E S  +PEL + P     L    + P   PG        P   PP        
Sbjct: 847  -------EESHLSPELEKPP-----LSPRPEKPPEEPGQCPAPEELPLFPPPGE------ 888

Query: 550  PENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPP 609
            P    L  EP    P +       LSP+ E   +SP              P+L    +PP
Sbjct: 889  PSLSPLLGEPALSEPGEP-----PLSPLPEELPLSPSGE-----------PSLSPQLMPP 932

Query: 610  SPALPRPSRSSPGLYTSPGQDSLQPTAVSP------PYG--GDISPVSPSRAWSPRAKQA 661
             P LP P         SP   +  P A+SP      P+G  GD  P SP  A        
Sbjct: 933  DP-LPPP--------LSPIITAAAPPALSPLGELEYPFGAKGDSDPESPLAA-------- 975

Query: 662  PRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPPP 721
              P   T              P SPP     + P             EP        PP 
Sbjct: 976  --PILET--------------PISPPPEANCTDP-------------EP-------VPPM 999

Query: 722  LPPPPPMSPSWSERSVSPLRP-ETEARPPSRQLQALLARNIINAARRKSASPRSAGAENP 780
            + PP P SP      V P  P   E  PP  Q   LL  +++         P+++    P
Sbjct: 1000 ILPPSPGSP------VGPASPILMEPLPP--QCSPLLQHSLV---------PQNS---PP 1039

Query: 781  RPFSPPRAPPPPPPPPPPPPR------------MRSPQPARPGSAAVPGAAFAPIPRSPL 828
               SPP  P   P P  P  +            M + + + P   A+  +A +P+P    
Sbjct: 1040 SQCSPPALPLSVPSPLSPIGKVVGVSDEAELHEMETEKVSEPECPALEPSATSPLPS--- 1096

Query: 829  PAGPSSCTSPRSPLPA 844
            P G  SC +P SP PA
Sbjct: 1097 PMGDLSCPAP-SPAPA 1111



 Score = 87.0 bits (214), Expect = 7e-17
 Identities = 154/630 (24%), Positives = 211/630 (33%), Gaps = 103/630 (16%)

Query: 248 PGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPAS 307
           P G + ++  P LE     E+ P   PP     SP P+    S  P   R         +
Sbjct: 418 PLGKAGVQLEPQLEAP-LNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPA 476

Query: 308 ERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSD-PKSSHLKGQAVPASKTGI 366
              P     + P     LS  P  S +  PP  S   P  + P S   +    PA +T +
Sbjct: 477 SPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPL 536

Query: 367 LEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGV----EEEPFA 422
                A   S      F E P ++P P+ L      +  R      E  +    EE P +
Sbjct: 537 SPPPEASPLSPP----FEESP-LSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMS 591

Query: 423 LGAEASN----FQQEP-APRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEAS 477
              EAS     F++ P +P    SP +     P  AS L  P   +   P P     E S
Sbjct: 592 PPPEASRLFPPFEESPLSPPPEESPLSP----PPEASRLSPPPEDSPMSPPP-----EES 642

Query: 478 GKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPA 537
                    R S +   V+   S  PE +    P    P+S   P  A         SP 
Sbjct: 643 PMSPPPEVSRLSPLP--VVSRLSPPPEESPLSPPPEESPTS--PPPEASRLSPPPEDSPT 698

Query: 538 RTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASP---AKPS 594
             PP        PE+ ++   P ++ P    P    L P  E   +SPR   P    +P 
Sbjct: 699 SPPPEDSPASPPPEDSLMSL-PLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPE 757

Query: 595 SLDLVPNLPKGALPPSPALP-----------RPSRSSPGLYTSPGQDSLQPTAVSP---- 639
              L P   +  L P P  P            P    P L   P +  L P    P    
Sbjct: 758 EPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSP 817

Query: 640 -PYGGDISPVSPSRAWSPRAKQ---APRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRP 695
            P    +SP       SP++++   +PRP  S  +  +E           PP +P   +P
Sbjct: 818 VPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELE----------KPPLSPRPEKP 867

Query: 696 PSSLDGWVSPGPWEPGRGSSMSSPPPLPPPPPMSPSWSERSVSPLRPETEARPPSRQLQA 755
           P            EPG+  +    P  PPP        E S+SPL  E     P     +
Sbjct: 868 PE-----------EPGQCPAPEELPLFPPP-------GEPSLSPLLGEPALSEPGEPPLS 909

Query: 756 LLARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQPARPGSAAV 815
            L   +          P S   E   P   P+  PP P PPP  P + +  P        
Sbjct: 910 PLPEEL----------PLSPSGE---PSLSPQLMPPDPLPPPLSPIITAAAPP------- 949

Query: 816 PGAAFAPIPRSPLPAGPSSCTSPRSPLPAP 845
              A +P+     P G    + P SPL AP
Sbjct: 950 ---ALSPLGELEYPFGAKGDSDPESPLAAP 976



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 95/341 (27%), Positives = 132/341 (38%), Gaps = 68/341 (19%)

Query: 556  RPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLV-PNLPKGA---LPPSP 611
            +P     PP    P++F+ SP   PA +S  A    KP +  +  P+ P      LPP  
Sbjct: 2109 QPGALGSPPPAAAPTIFIGSPTT-PAGLSTSADGFLKPPAGSVPGPDSPGELFLKLPPQV 2167

Query: 612  ALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNA 671
                PS+   GL  +   +   PTA  P Y     P  PS   +P   Q P    S+R  
Sbjct: 2168 PAQVPSQDPFGLAPAYPLEPRFPTA-PPTY-----PPYPSPTGAPA--QPPMLGASSRPG 2219

Query: 672  GIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPG---------PWEPGRGSSMSSPPPL 722
              +  +      T+PP TP     PS+ D ++ P          P  PG G   +S P L
Sbjct: 2220 AGQPGE----FHTTPPGTP--RHQPSTPDPFLKPRCPSLDNLAVPESPGVGGGKASEPLL 2273

Query: 723  PPPPPMSPSWSERSVSPLRPETEARPPSRQ------LQALLARNIINAARRKSA----SP 772
             PPP      S +++   + E  A  PS        + +  +   +     K+     +P
Sbjct: 2274 SPPPFGE---SRKALEVKKEELGASSPSYGPPNLGFVDSPSSGTHLGGLELKTPDVFKAP 2330

Query: 773  RSAGAENPRPFSP-----PRAPPP-----PPPPPPP--------------PPRMRSPQPA 808
             +  A    P SP     P+ PPP     P PP  P              PP    PQP 
Sbjct: 2331 LTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPP 2390

Query: 809  RPGSA-AVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAPPRP 848
             P S  A+P  +    P S +PA P S +S +SPL   PRP
Sbjct: 2391 PPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPL--TPRP 2429



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 179/793 (22%), Positives = 257/793 (32%), Gaps = 142/793 (17%)

Query: 22   EEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLT 81
            E  PL    +E+        L  S   EA + SP P  + +  P  +   +    ++ L 
Sbjct: 541  EASPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLF 600

Query: 82   TPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADG 141
             P   S  +PP  +   +PP      S P      +    + P +     S+ S L    
Sbjct: 601  PPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVS 660

Query: 142  QPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTL 201
            +   P EE   S    +  ++P    S  S      P+S PP     S        P   
Sbjct: 661  RLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASP------PPEDS 714

Query: 202  VVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLE 261
            ++S   E S                  L + P +  R+  P              SP  E
Sbjct: 715  LMSLPLEESPL--------------LPLPEEPQLCPRSEGP------------HLSPRPE 748

Query: 262  RRHFGEKAPAPQPPSL------PDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNF 315
              H    +P P+ P L      P  SP+P+   +   P           P    +P    
Sbjct: 749  EPHL---SPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELH 805

Query: 316  TAPPTYTETLSTAPLASWVRSPPSYSVLYPSSD-------PKSSHLKGQAVPASKTGILE 368
             +P T    LS  P    +   P  S L P S+       P+ SHL  +         LE
Sbjct: 806  LSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPE---------LE 856

Query: 369  ESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEE--EPFALGAE 426
            +        K      E+P   P P+ L L     E       GE  + E  EP  L   
Sbjct: 857  KPPLSPRPEKP----PEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEP-PLSPL 911

Query: 427  ASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYAR 486
                   P+     SP   + + P+      SP I A   P  +         GA+  + 
Sbjct: 912  PEELPLSPSGEPSLSP---QLMPPDPLPPPLSPIITAAAPPALSPLGELEYPFGAKGDSD 968

Query: 487  RQSRMEKYVIESSSHTPELARC----PSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPA 542
             +S +   ++E+    P  A C    P P M LP S   P        +    P  +P  
Sbjct: 969  PESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPGSPVGPASPILMEPLPPQCSP-- 1026

Query: 543  SLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPI--------------KEPAKVSPRAA 588
             L H  +P+N    P     PP         LSPI               E  KVS    
Sbjct: 1027 LLQHSLVPQNS---PPSQCSPPALPLSVPSPLSPIGKVVGVSDEAELHEMETEKVSEPEC 1083

Query: 589  SPAKPSSLDLVPNLPKGAL-----PPSPAL-----------PRPSRSSPGLYTSPGQ--D 630
               +PS+   +P+ P G L      P+PAL           P     +PG    PGQ   
Sbjct: 1084 PALEPSATSPLPS-PMGDLSCPAPSPAPALDDFSGLGEDTAPLDGIDAPGSQPEPGQTPG 1142

Query: 631  SL------QPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPT 684
            SL       P  + P    +++PV+P   + P  KQ       T   G   +++ E    
Sbjct: 1143 SLASELKGSPVLLDPE---ELAPVTPMEVY-PECKQ-------TAGQGSPCEEQEE---- 1187

Query: 685  SPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPP---PL--PPPPPMSPSWS-----E 734
              P  P A  PP+ +   +        +G + +S P   PL   P P    S S      
Sbjct: 1188 --PRAPVAPTPPTLIKSDIVNEISNLSQGDASASFPGSEPLLGSPDPEGGGSLSMELGVS 1245

Query: 735  RSVSPLRPETEAR 747
              VSP R E   R
Sbjct: 1246 TDVSPARDEGSLR 1258



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 96/350 (27%), Positives = 125/350 (35%), Gaps = 65/350 (18%)

Query: 563  PPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPS-----PALPRPS 617
            P Y L P  F  +P   P   SP  A PA+P  L    + P    P       P  PR  
Sbjct: 2181 PAYPLEPR-FPTAPPTYPPYPSPTGA-PAQPPMLG-ASSRPGAGQPGEFHTTPPGTPRHQ 2237

Query: 618  RSSPGLYTSPGQDSLQPTAV--SPPYGGDIS--------PVSPSRAWSPRAKQ---APRP 664
             S+P  +  P   SL   AV  SP  GG  +        P   SR      K+   A  P
Sbjct: 2238 PSTPDPFLKPRCPSLDNLAVPESPGVGGGKASEPLLSPPPFGESRKALEVKKEELGASSP 2297

Query: 665  SFSTRNAG-IEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPPP-- 721
            S+   N G +++      L      TP   + P +        P  PG G     PPP  
Sbjct: 2298 SYGPPNLGFVDSPSSGTHLGGLELKTPDVFKAPLTPRA-SQVEPQSPGLGLRPQEPPPAQ 2356

Query: 722  -LPPPPPMSP------SWSERSVSPLRPETEARPPSRQLQALLARNI-------INAARR 767
             L P PP  P      S+++    P        PP     AL  R++       + A+ +
Sbjct: 2357 ALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQ 2416

Query: 768  KSAS--------PRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSP-----QPARP---- 810
              +S        P SA A  P P +P    P P   PP  P+ R P     +P RP    
Sbjct: 2417 SQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPPRPQPPE 2476

Query: 811  -----GSAAVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAPPRPFLYRRSP 855
                 GS A         P + LPAGP+     + P   PP    + RSP
Sbjct: 2477 VAFKAGSLAHTSLGAGGFP-AALPAGPAGELHAKVPSGQPPN---FVRSP 2522



 Score = 53.5 bits (127), Expect = 9e-07
 Identities = 82/297 (27%), Positives = 109/297 (36%), Gaps = 42/297 (14%)

Query: 581  AKVSPRAASPAKPSS--LDLVPNLPKGALPPSPALP-RPSRSSPGLYTSP-GQDSLQPTA 636
            A ++PRA S  +P S  L L P  P  A   +P+ P  P    PG YT P  Q  L P  
Sbjct: 2329 APLTPRA-SQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPYAQPPLTPRP 2387

Query: 637  VSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPP 696
              PP         P    +   +  P   FS   A  ++Q   +S  T  P +  A  P 
Sbjct: 2388 QPPP---------PESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPS 2438

Query: 697  SSLDGWVSPGPWE--PGRGSSMSSPPPLPPPP-PMSPSWSERSVSPLR--------PETE 745
                 + SP P+   P R  S     PL  PP P  P  + ++ S           P   
Sbjct: 2439 PVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPPRPQPPEVAFKAGSLAHTSLGAGGFPAAL 2498

Query: 746  ARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSPPRA------PPPPPPPPPPP 799
               P+ +L A +         R   +    G  +P  F+ P+A       PP P P  PP
Sbjct: 2499 PAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPPVPQPGLPP 2558

Query: 800  PR------MRSPQPARPGSA--AVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAPPRP 848
            P          P   +P S    V    F P   S  P GPSS ++  S   +P RP
Sbjct: 2559 PHGINSHFGPGPTLGKPQSTNYTVATGNFHP---SGSPLGPSSGSTGESYGLSPLRP 2612



 Score = 53.5 bits (127), Expect = 9e-07
 Identities = 153/713 (21%), Positives = 246/713 (34%), Gaps = 136/713 (19%)

Query: 238  RTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRS--PMV 295
            R   P  + AP G   +   P+L   H      +PQ P  P + P P   + + +  P  
Sbjct: 4282 RPQGPPRLPAPPGA--LSTGPVLGPVHPTPPPSSPQEPKRPSQLPSPSSQLPTEAQLPPT 4339

Query: 296  ERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHL- 354
                   + P  E  P     A     +TL +  L  W   PP    L  +  P+ S L 
Sbjct: 4340 HPGTPKPQGPTLEPPPGRVSPAAAQLADTLFSKGLGPW--DPPDN--LAETQKPEQSSLV 4395

Query: 355  -------KGQAVP-ASKTGILEE-----------SMARRGSRK-------SMFTFVEKPK 388
                    GQ VP AS+  I +E           S+ R  + +       S    +  P+
Sbjct: 4396 PGHLDQVNGQVVPEASQLSIKQEPREEPCALGAQSVKREANGEPIGAPGTSNHLLLAGPR 4455

Query: 389  VTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFA-LGAEASNFQQ--EPAPRDRASPAAA 445
                  LL  +  A   +    +G  G+  E    + ++ +  +Q  +  P ++   AA 
Sbjct: 4456 SEAGHLLLQKLLRAKNVQLSTGRGSEGLRAEINGHIDSKLAGLEQKLQGTPSNKEDAAAR 4515

Query: 446  EEVVPEWASCLK-SPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPE 504
            + + P+     K S R+ +  K      L +  G  A     +Q + E  ++  +    E
Sbjct: 4516 KPLTPKPKRVQKASDRLVSSRK-----KLRKEDGVRASEALLKQLKQELSLLPLT----E 4566

Query: 505  LARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPE------ 558
             A   + ++  P     P N     R A  S A       Y   L +N +  P       
Sbjct: 4567 PAITANFSLFAPFGSGCPVNGQSQLRGAFGSGALPTGPDYYSQLLTKNNLSNPPTPPSSL 4626

Query: 559  PTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSR 618
            P   PP   +  +  ++P +E  +  P+ A+ A+ S   L       +L    ALP P  
Sbjct: 4627 PPTPPPSVQQKMVNGVTPSEELGE-HPKDAASARDSERALRDTSEVKSLDLLAALPTPPH 4685

Query: 619  S-SPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQD 677
            + +  +     +DS  P ++ P           S   S   ++APR  F    +G   Q+
Sbjct: 4686 NQTEDVRMESDEDSDSPDSIVPA----------SSPESILGEEAPR--FPHLGSGRWEQE 4733

Query: 678  RRESLPTSPPWTPGASRP------PSSLDGWVSPGP-----WEPGRGSSMS--------- 717
             R   P  P   P AS P      P    G   PG      WE G+GS +S         
Sbjct: 4734 DRALSPVIP-LIPRASIPVFPDTKPYGALGLEVPGKLPVTTWEKGKGSEVSVMLTVSAAA 4792

Query: 718  ---------------------SPPPLPPPPPM------------SPSWSERSVSPLRPET 744
                                 S   L P  P              P   E+ +    P+T
Sbjct: 4793 AKNLNGVMVAVAELLSMKIPNSYEVLFPESPARAGTEPKKGEAEGPGGKEKGLEGKSPDT 4852

Query: 745  --------EARPPSRQLQALLARNIINAARRKSASP----RSAGAENPRPFSPPRAPPPP 792
                    +A  P   L++ L  +I++  +++S +P    + +   N       +   PP
Sbjct: 4853 GPDWLKQFDAVLPGYTLKSQL--DILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPP 4910

Query: 793  PPPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAP 845
            P  P PPP   +P PA P +  +      P+   P+P+     +SP S  P P
Sbjct: 4911 PEEPSPPPSPLAPSPASPPTEPLVELPTEPLAEPPVPSPLPLASSPESARPKP 4963



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 137/619 (22%), Positives = 191/619 (30%), Gaps = 83/619 (13%)

Query: 272  PQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLA 331
            PQP +L    P     I   SP          +PA        F  PP  +     +P  
Sbjct: 2108 PQPGALGSPPPAAAPTIFIGSPT---------TPAGLSTSADGFLKPPAGSVPGPDSPGE 2158

Query: 332  SWVRSPPSYSVLYPSSDP----KSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKP 387
             +++ PP      PS DP     +  L+ +   A  T     S     ++  M     +P
Sbjct: 2159 LFLKLPPQVPAQVPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAPAQPPMLGASSRP 2218

Query: 388  --------KVTPNPDLLDLVQTADE--KRRQRDQGEVGVEEEPFALGAEASNFQQEPAP- 436
                      TP         T D   K R      + V E P   G +AS     P P 
Sbjct: 2219 GAGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVGGGKASEPLLSPPPF 2278

Query: 437  -RDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYV 495
               R +    +E +   +     P +     P    +L     K  +++    +     V
Sbjct: 2279 GESRKALEVKKEELGASSPSYGPPNLGFVDSPSSGTHLGGLELKTPDVFKAPLTPRASQV 2338

Query: 496  IESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRS-PARTPPASLYHGYLPENGV 554
               S       + P P  +L  S   P + P  FR  S + P   PP             
Sbjct: 2339 EPQSPGLGLRPQEPPPAQALAPS---PPSHPDIFRPGSYTDPYAQPP------------- 2382

Query: 555  LRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRA-ASPAKPSSLD--LVPN-LPKGALPPS 610
            L P P   PP     S   L P   P+    R  ASP   SS    L P  L   A  PS
Sbjct: 2383 LTPRPQPPPP----ESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPS 2438

Query: 611  PALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSF---S 667
            P  PR        + SP   S  P   S P   D  P +P     P   Q P  +F   S
Sbjct: 2439 PVTPR--------FQSPDPYSRPP---SRPQSRD--PFAPLH--KPPRPQPPEVAFKAGS 2483

Query: 668  TRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPPP 727
              +  + A     +LP  P     A  P      +V      PG G+ + +P P+    P
Sbjct: 2484 LAHTSLGAGGFPAALPAGPAGELHAKVPSGQPPNFVR----SPGTGAFVGTPSPMRFTFP 2539

Query: 728  MSPSWSERSVSPLRPETEARPP---------SRQLQALLARNIINAARRKSASPRSAGAE 778
             +    E S+ P  P+    PP            L    + N   A      S    G  
Sbjct: 2540 QAVG--EPSLKPPVPQPGLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPS 2597

Query: 779  NPRPFSPPRAPPPPPPPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCTSP 838
            +          P  PP   PPP      P     A+      +P+ +   P      +  
Sbjct: 2598 SGSTGESYGLSPLRPPSVLPPPAPDGSLPYLSHGASQRSGITSPVEKREDPGTGMGSSLA 2657

Query: 839  RSPLPAPPRPFLYRRSPTD 857
             + LP    P +   S T+
Sbjct: 2658 TAELPGTQDPGMSGLSQTE 2676



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 52/180 (28%), Positives = 71/180 (39%), Gaps = 42/180 (23%)

Query: 647  PVSPSRAWS-PRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWT-------PGASRPPS- 697
            P SP+RA + P+  +A  P    +  G+E +    S  T P W        PG +     
Sbjct: 4820 PESPARAGTEPKKGEAEGPG--GKEKGLEGK----SPDTGPDWLKQFDAVLPGYTLKSQL 4873

Query: 698  ---SLDGWVSPGPWEPGRGS-----------SMSSPPPLPPPPPMSPSWSERSVSPLRPE 743
               SL    SP P  P + S            +S+PPP  P PP          SPL P 
Sbjct: 4874 DILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPP---------PSPLAP- 4923

Query: 744  TEARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMR 803
            + A PP+  L  L    +       S  P ++  E+ RP   PRA PP       PPR++
Sbjct: 4924 SPASPPTEPLVELPTEPLAEPP-VPSPLPLASSPESARP--KPRARPPEEGEDSRPPRLK 4980



 Score = 38.1 bits (87), Expect = 0.037
 Identities = 60/229 (26%), Positives = 77/229 (33%), Gaps = 46/229 (20%)

Query: 608  PPSPALPRPSRSS-------PGLYTSPGQDSLQPTAVSPPYG-------GDISPVSPSRA 653
            P  P L RP +++       PG     GQ  L    + P  G       G ++     R 
Sbjct: 4155 PQQPMLERPMQNNTGPQPPKPGPVLQSGQ-GLPGVGIMPTVGQLRAQLQGVLAKNPQLRH 4213

Query: 654  WSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPP--------SSLDGWVSP 705
             SP+ +Q  +     R    + Q  +    T P   PG    P          L G+  P
Sbjct: 4214 LSPQQQQQLQALLMQR----QLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPGP 4269

Query: 706  --GPW-EPGRGSSMSSPPPLPPPP-PMSPSWSERSVSPLRPETEARPPSRQLQALLARNI 761
              GP  E G G     PP LP PP  +S       V P  P +  + P R  Q       
Sbjct: 4270 QTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQL------ 4323

Query: 762  INAARRKSASPRSA-GAENPRPFSPPRAPPPPPPPPPPPPRMRSPQPAR 809
                     SP S    E   P + P  P P  P   PPP   SP  A+
Sbjct: 4324 --------PSPSSQLPTEAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQ 4364



 Score = 37.7 bits (86), Expect = 0.049
 Identities = 150/699 (21%), Positives = 240/699 (34%), Gaps = 108/699 (15%)

Query: 57   PPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPP----ATVVPQSLPLS 112
            PPPA+  +P+   + ++  P +  T P +     PP T   Q PP      + P+SLP  
Sbjct: 2352 PPPAQALAPSPPSHPDIFRPGS-YTDPYAQ----PPLTPRPQPPPPESCCALPPRSLPSD 2406

Query: 113  SIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSR 172
               +  +  Q  S+   P + P  L A+    +P      S    D  S P +   +   
Sbjct: 2407 PFSRVPASPQSQSSSQSPLT-PRPLSAEAFCPSPVTPRFQSP---DPYSRPPSRPQSRDP 2462

Query: 173  EATLI--PSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLA 230
             A L   P  +PP   F + SL           +     +G   A  P     E+H   A
Sbjct: 2463 FAPLHKPPRPQPPEVAFKAGSL-----------AHTSLGAGGFPAALPAGPAGELH---A 2508

Query: 231  KPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGE-------KAPAPQPPSLPDRSPR 283
            K PS      +P       GT     +P   R  F +       K P PQP   P   P 
Sbjct: 2509 KVPS-----GQPPNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPPVPQPGLPP---PH 2560

Query: 284  PQRHIMSRSPMVERRMMGQRSPASER-RPLGNFTAPPTYT--ETLSTAPLASWVRSPPSY 340
                     P + +      + A+    P G+   P + +  E+   +PL      PP  
Sbjct: 2561 GINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSGSTGESYGLSPLRPPSVLPP-- 2618

Query: 341  SVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKV--TPNPDLLDL 398
                P+ D    +L   A  + ++GI      R      M + +   ++  T +P +  L
Sbjct: 2619 ----PAPDGSLPYLSHGA--SQRSGITSPVEKREDPGTGMGSSLATAELPGTQDPGMSGL 2672

Query: 399  VQTADEKRRQRDQ-GEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLK 457
             QT  EK+RQR +  E+ + ++           Q+    +++ + AAA   V    S   
Sbjct: 2673 SQTELEKQRQRQRLRELLIRQQ----------IQRNTLRQEKETAAAAAGAVGPPGSWGA 2722

Query: 458  SPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPE--LARCPSPT--M 513
             P   A  +    Q     +   + L     S++   ++   S   +  L+R P P    
Sbjct: 2723 EPSSPAFEQLSRGQTPFAGTQDKSSLVGLPPSKLSGPILGPGSFPSDDRLSRPPPPATPS 2782

Query: 514  SLPSSWKYPTNAPGAFRVASRSPARTP---------------PASLYHGYLPENGVLRPE 558
            S+  + +       AF   +  P   P                A+     +       P 
Sbjct: 2783 SMDVNSRQLVGGSQAFYQRAPYPGSLPLQQQQQQLWQQQQATAATSMRFAMSARFPSTPG 2842

Query: 559  PTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALP---PSPALPR 615
            P         P   + + +  P +  P  A PA+   ++L  N+ KG  P   P P    
Sbjct: 2843 PELGRQALGSPLAGISTRLPGPGEPVPGPAGPAQ--FIELRHNVQKGLGPGGTPFPGQGP 2900

Query: 616  PSRSSPGLY-TSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIE 674
            P R  P  Y  S     L P  +       + P  PS   +P    +  P+  T+     
Sbjct: 2901 PQR--PRFYPVSEDPHRLAPEGLRGLAVSGLPPQKPSAPPAPELNNSLHPTPHTKG---- 2954

Query: 675  AQDRRESLPTSPPWTPGASRPPSSLD-GWVSPGPWEPGR 712
                    PT P      +RPPSS + G  +P   E G+
Sbjct: 2955 --------PTLPTGLELVNRPPSSTELGRPNPLALEAGK 2985



 Score = 37.7 bits (86), Expect = 0.049
 Identities = 26/81 (32%), Positives = 31/81 (38%), Gaps = 16/81 (19%)

Query: 780  PRPFSPPRAPPPP--------------PPPPPPPPRMRSPQPARPGSAAVPGAAFAP--I 823
            PRP  PPR P PP               PPP  P   + P      S+ +P  A  P   
Sbjct: 4281 PRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQLPSPSSQLPTEAQLPPTH 4340

Query: 824  PRSPLPAGPSSCTSPRSPLPA 844
            P +P P GP+    P    PA
Sbjct: 4341 PGTPKPQGPTLEPPPGRVSPA 4361



 Score = 35.4 bits (80), Expect = 0.24
 Identities = 72/293 (24%), Positives = 105/293 (35%), Gaps = 53/293 (18%)

Query: 579  EPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVS 638
            EP +V P   S +  S L LV   P+   P S  L  P R        PGQ   Q + + 
Sbjct: 4061 EPGEVKP---SLSGDSQLLLVQPQPQPQ-PSSLQLQPPLRL-------PGQQQQQVSLLH 4109

Query: 639  PPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTS--PPWTPGASRPP 696
               GG     S  +  S  + +A           +   D+  S+  +   P  P   RP 
Sbjct: 4110 TAGGG-----SHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPM 4164

Query: 697  SSLDGWVSPGPWEPGRGSSMSSPPPLPPPPPMSPSWSERS----VSPLRPETEARPPSRQ 752
             +     + GP  P  G  + S   LP    M      R+    V    P+     P +Q
Sbjct: 4165 QN-----NTGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQ 4219

Query: 753  --LQALLARNIINAARRKSASP--RSAGAEN----------------PRPFSPPRAPPPP 792
              LQALL +  +  ++    +P  +  G +                 P P + P      
Sbjct: 4220 QQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPGPQTGPLQELGA 4279

Query: 793  PPPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAP 845
             P P  PPR+    PA PG+ +  G    P+  +P P+ P     P S LP+P
Sbjct: 4280 GPRPQGPPRL----PAPPGALST-GPVLGPVHPTPPPSSPQEPKRP-SQLPSP 4326



 Score = 35.0 bits (79), Expect = 0.32
 Identities = 29/109 (26%), Positives = 42/109 (38%), Gaps = 16/109 (14%)

Query: 550  PENGVLR-----PEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPK 604
            P+ G L+     P P   P     P      P+  P   +P  +SP +P     +P+   
Sbjct: 4269 PQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQLPS--- 4325

Query: 605  GALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRA 653
                PS  LP  ++  P   T PG    Q   + PP  G +SP +   A
Sbjct: 4326 ----PSSQLPTEAQLPP---THPGTPKPQGPTLEPP-PGRVSPAAAQLA 4366



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 36/108 (33%), Positives = 40/108 (37%), Gaps = 21/108 (19%)

Query: 535  SPARTPPASLYHGYLPENGVLR------PEPTKQPPYQLRPSLFVLSPIKEPAKVSPRA- 587
            SPA  PP    + Y   N  +R      PE    PP  L PS    SP  EP    P   
Sbjct: 4883 SPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPS--PASPPTEPLVELPTEP 4940

Query: 588  -ASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQP 634
             A P  PS L L       A  P  A P+P    P      G+DS  P
Sbjct: 4941 LAEPPVPSPLPL-------ASSPESARPKPRARPP----EEGEDSRPP 4977


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 117/452 (25%), Positives = 164/452 (36%), Gaps = 96/452 (21%)

Query: 420 PFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGK 479
           PF L +++   Q+E   + +      E+  PE    +K P  Q  PKP P Q      G 
Sbjct: 175 PFDLISDSEASQEETTKKQKV--VQKEQGKPE--GIIKPPLQQQPPKPIPKQQ-----GP 225

Query: 480 GAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPART 539
           G +    +Q    K +   SS  PE  +   P    P                 + P +T
Sbjct: 226 GRD--PLQQDGTPKSI---SSQQPEKIKSQPPGTGKPI----------------QGPTQT 264

Query: 540 PPASLYHGYLP-ENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDL 598
           P     H  LP +    RP+ TKQ            + I     V P   SP+KP     
Sbjct: 265 PQTD--HAKLPLQRDASRPQ-TKQ------------ADIVRGESVKPSLPSPSKPPIQQP 309

Query: 599 VPNLPKGALP------PSPALP--RPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSP 650
            P  P    P      P PA P  +PS  +  L   PG  +++P  V PP G    P  P
Sbjct: 310 TPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPG--TVKPP-VQPP-GTTKPPAQP 365

Query: 651 SRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEP 710
                P A+Q      S+   G +A  +   +  +P   PG ++PP+   G   P   +P
Sbjct: 366 LGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQP 425

Query: 711 GRGSSMSSPPPLPPPPPMSPSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSA 770
           G  S   +P P              + +P++     + P++Q                 A
Sbjct: 426 GLQSPAKAPGP--------------TKTPVQQPGPGKIPAQQ-----------------A 454

Query: 771 SPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQPARPGSAAVPG---AAFAPIPRSP 827
            P    A+   P  PP   P P  PPP  P    P P +PGSA  P     +  P P+ P
Sbjct: 455 GPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQP 514

Query: 828 LPAGPS----SCTSPRSPLPAPPRPFLYRRSP 855
            PA PS      T P S  P   +P   + SP
Sbjct: 515 GPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSP 546



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 184/845 (21%), Positives = 287/845 (33%), Gaps = 128/845 (15%)

Query: 51   QQSSPAPPPAEVHSPAADVNQ-NLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSL 109
            QQ +P  PPA+   P  + +Q   A P A  +  T   +  P        PP T  P + 
Sbjct: 307  QQPTPGKPPAQ--QPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQ 364

Query: 110  PLSSIQQNSSEAQLPSNGTG---PASKPSTLCADGQP----QAPAEEVRCSTLLIDKVST 162
            PL         A+ P+  TG   P+S+     A  QP    + PA++   +     +V T
Sbjct: 365  PLGP-------AKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGT 417

Query: 163  PATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAA--TTPTK 220
            P              P  + PA     +   +  QP    + A Q   G+ +A  T PTK
Sbjct: 418  PKPLAQQ--------PGLQSPAKAPGPTKTPVQ-QPGPGKIPAQQAGPGKTSAQQTGPTK 468

Query: 221  VYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDR 280
              S++    AKPP      A+P   Q PG      + P   +    +  PA   P  P  
Sbjct: 469  PPSQLPGP-AKPPPQQPGPAKP-PPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGS 526

Query: 281  SPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSY 340
            +  P +   S  P  +     Q SPA   +P    +  P  ++T S  PL      PP+ 
Sbjct: 527  TKPPSQQPGSAKPSAQ-----QPSPA---KPSAQQSTKPV-SQTGSGKPL-----QPPTV 572

Query: 341  SVLYPSS-DPKSSHLKGQAVPASKTGILEESMARRGS----RKSMFTFVEKPKVTPNPDL 395
            S   PS+  P S  L     P   T  L   +  + +     +   T        PNP L
Sbjct: 573  S---PSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHL 629

Query: 396  LDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASC 455
             ++ +      + +            ALG + +     P P+ + +P      V      
Sbjct: 630  TEVKEWLCLNCQMKR-----------ALGGDLAPVPSSPQPKLKTAPVTTTSAV------ 672

Query: 456  LKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSL 515
                   +K  P+P Q   +                     + ++   +L++ P P    
Sbjct: 673  -------SKSSPQPQQTSPK---------------------KDAAPKQDLSKAPEPKKP- 703

Query: 516  PSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLS 575
            P   K PT        +  + A+ PP +        + + +P P K+P     PS    +
Sbjct: 704  PPLVKQPT-----LHGSPSAKAKQPPEA--------DSLSKPAPPKEPSV---PSEQDKA 747

Query: 576  PIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPT 635
            P+ +     P+   P    + DLV +      P  P+    S++          DS +P+
Sbjct: 748  PVADDKPKQPKMVKP----TTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPS 803

Query: 636  AVSPPYGGDISPVSPSRAWSPRA--KQAPRPSFSTRNAGIE----AQDRRESLPTSPPWT 689
               PP G  +SP        P +  K    P  S+ + G +     Q + E        +
Sbjct: 804  QSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMS 863

Query: 690  PGASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPPPMSPSWSERSVSPL-RPETEARP 748
            P     P        PGP  P  G ++ +P   P P   S  +S    S    P+++   
Sbjct: 864  PKPDAKPMPKGSPTPPGP-RPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTT 922

Query: 749  PSRQLQALLARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQPA 808
            P   +   L     +   + S    +AG   P   S P AP    P P  PP  + P P 
Sbjct: 923  PQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGP-PK 981

Query: 809  RPGSAAVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAPPRPFLYRRSPTDSD-VSLDSEDS 867
              G A    A   P+ +                 P   R    ++ P   D  SL +E  
Sbjct: 982  STGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQ 1041

Query: 868  GAKSP 872
             A  P
Sbjct: 1042 KAVLP 1046



 Score = 70.9 bits (172), Expect = 5e-12
 Identities = 102/423 (24%), Positives = 150/423 (35%), Gaps = 59/423 (13%)

Query: 401 TADEKRRQRDQGEV-GVEEEPFALGAEASNFQQEPAPRDR----ASPAAAEEVVPEWASC 455
           T  +K  Q++QG+  G+ + P          +Q+   RD      +P +     PE    
Sbjct: 190 TKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPE--KI 247

Query: 456 LKSPRIQAKPKPKPNQNLSEASGK-GAELYARRQSRMEKYVIESSSHTPELARCPSPTMS 514
              P    KP   P Q       K   +  A R    +  ++   S  P L     P + 
Sbjct: 248 KSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQ 307

Query: 515 LPSSWKYPTNAPGAFRVASRSPARTP--PASLYHGYLPENGVLRPEPTKQPPYQLRPSLF 572
            P+  K P   PG  + +   PA+ P  P+ L      + G ++P    QPP   +P   
Sbjct: 308 QPTPGKPPAQQPGHEK-SQPGPAKPPAQPSGLTKPLAQQPGTVKPPV--QPPGTTKPPAQ 364

Query: 573 VLSPIKEPAKVS----PRAASP-----AKPSSLDLVP-NLPKGALPPSPAL--PRPSRSS 620
            L P K PA+ +    P +  P     A+P  +   P   P  A PP+  +  P+P    
Sbjct: 365 PLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQ 424

Query: 621 PGLYTSPGQDSLQPTAVSPPYGGDI--SPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDR 678
           PGL +         T V  P  G I      P +  + +      PS     A    Q  
Sbjct: 425 PGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQP 484

Query: 679 RESLPTSPPWTPGASRPPSSLDGWVSP-----GPWEPGRGSSMSSPPPLPPPPPMSPSWS 733
             + P  PP  PG+++PPS   G   P     GP +P      S+ PP   P    PS  
Sbjct: 485 GPAKP--PPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQ 542

Query: 734 ERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPP 793
           + S         A+P ++Q               K  S   +G    +P  PP   P   
Sbjct: 543 QPS--------PAKPSAQQ-------------STKPVSQTGSG----KPLQPPTVSPSAK 577

Query: 794 PPP 796
            PP
Sbjct: 578 QPP 580



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 124/543 (22%), Positives = 177/543 (32%), Gaps = 106/543 (19%)

Query: 384 VEKPKVTPNPDLLDLVQTADEKRRQRDQGEV--GVEEEPFALGAEASNFQQEPAP----- 436
           ++ P  TP  D   L    D  R Q  Q ++  G   +P +L + +    Q+P P     
Sbjct: 258 IQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKP-SLPSPSKPPIQQPTPGKPPA 316

Query: 437 ----RDRASPAAAEEVVPEWASCLKSPRIQAK-----PKPKPNQNLSEASGKGAELYARR 487
                +++ P  A+   P   S L  P  Q       P   P      A   G      +
Sbjct: 317 QQPGHEKSQPGPAKP--PAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQ 374

Query: 488 QSRMEKYVIESS-----SHTPELARCPS--PTMSLPSSWKYPTNAPGAFRVASRSPARTP 540
           Q+  EK   E       +  P + + P+  P  + P + +  T  P A +   +SPA+ P
Sbjct: 375 QTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAP 434

Query: 541 PASLYHGYLPENGVLRPEPTKQPPYQLRP---SLFVLSPIKEP------AKVSPRAASPA 591
             +       +  V +P P K P  Q  P   S     P K P      AK  P+   PA
Sbjct: 435 GPT-------KTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPA 487

Query: 592 KP---------------SSLDLVPNLPKGALPPSPALP---RPSRSSPG------LYTSP 627
           KP                S    P  P G   PSP  P   +P    PG         SP
Sbjct: 488 KPPPQQPGSAKPPSQQPGSTKPPPQQP-GPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSP 546

Query: 628 GQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPR--------------------PSFS 667
            + S Q +       G   P+ P    SP AKQ P                     P  +
Sbjct: 547 AKPSAQQSTKPVSQTGSGKPLQPPTV-SPSAKQPPSQGLPKTICPLCNTTELLLHVPEKA 605

Query: 668 TRNAGIEAQDRRESLPTSPP---------WTPGASRPPSSLDGWVSPGPWEPGRGSSMSS 718
             N   E Q    SL    P         W     +   +L G ++P P         SS
Sbjct: 606 NFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVP---------SS 656

Query: 719 PPPLPPPPPMSPSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAE 778
           P P     P++ + +    SP   +T  +  +   Q L               P   G+ 
Sbjct: 657 PQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSP 716

Query: 779 NPRPFSPPRAPPPPPPPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCTSP 838
           + +   PP A     P PP  P + S Q   P +   P       P + L +  S+ T P
Sbjct: 717 SAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKP 776

Query: 839 RSP 841
             P
Sbjct: 777 DIP 779



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 66/247 (26%), Positives = 88/247 (35%), Gaps = 62/247 (25%)

Query: 608  PPSP--ALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPS 665
            PPS   ALP   + S   +TS      +  A   P G      SPS +  P     PRP 
Sbjct: 2343 PPSSVIALPMKEQLSTTYFTSGETFGQEKPASQLPSG------SPSVSSLPAK---PRPF 2393

Query: 666  FSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLPPP 725
            F + +  I AQ      P  PP  P    PP                      PPP PPP
Sbjct: 2394 FRSSSLDISAQ------PPPPPPPPPPPPPP----------------------PPPPPPP 2425

Query: 726  PPMSPSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSP 785
            P   P+  + ++ P +  T A P +       A   +      +A  RS G    R  + 
Sbjct: 2426 PLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLET----TAVLRSNGLPVTRICT- 2480

Query: 786  PRAPPPPPPPPPPPPR----MRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCTSPRSP 841
              APPP PP P   P        P+P++P             P +P P  P   T+ + P
Sbjct: 2481 -TAPPPVPPKPSSIPSGLVFTHRPEPSKP-------------PIAPKPVIPQLPTTTQKP 2526

Query: 842  LPAPPRP 848
                P+P
Sbjct: 2527 TDIHPKP 2533



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 134/639 (20%), Positives = 218/639 (34%), Gaps = 113/639 (17%)

Query: 50   AQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSL 109
            AQQ+ P  PP+++  PA    Q    P      P    S  PP    +Q P +T  P   
Sbjct: 461  AQQTGPTKPPSQLPGPAKPPPQ---QPGPAKPPPQQPGSAKPP----SQQPGSTKPPPQQ 513

Query: 110  PLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAE-EVRCSTLLIDKVSTPATTTS 168
            P  +        Q P +   P+ +P +     Q  +PA+   + ST  + +     T + 
Sbjct: 514  PGPA----KPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQ-----TGSG 564

Query: 169  TFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYS----- 223
               +  T+ PS++ P S  +  ++        L++   ++ +        T V S     
Sbjct: 565  KPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFN 624

Query: 224  -EVHFTLAKPPSVVNRTARPF--GIQAPGGTS---QMERSPMLERRHFGEKAPAPQPPSL 277
               H T  K    +N   +    G  AP  +S   +++ +P+       + +P PQ  S 
Sbjct: 625  PNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTS- 683

Query: 278  PDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSP 337
            P +   P++  +S++P  ++     + P     P      PP        AP      S 
Sbjct: 684  PKKDAAPKQD-LSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKE--PSV 740

Query: 338  PSYSVLYPSSDPK--------------------------SSHLKGQA----VPASKTGIL 367
            PS     P +D K                          SS ++ QA     P  KT   
Sbjct: 741  PSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSA 800

Query: 368  E--ESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGA 425
            +  +S    G + S F     P+   +  ++     + E + Q+    V  +EEP     
Sbjct: 801  KPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQT 860

Query: 426  EAS----------NFQQEPAPRDRAS---PAAAEEVVPEWAS---CLKSPRIQAKPKPKP 469
            + S               P PR  A    P   +   P+  S    L    I   PK +P
Sbjct: 861  KMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQP 920

Query: 470  NQNLSEASGK----GAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNA 525
                   +GK    GA ++++            +S+    A  P P         +  + 
Sbjct: 921  TTPQETVTGKLFGFGASIFSQ------------ASNLISTAGQPGP---------HSQSG 959

Query: 526  PGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLR---PSLFVLSPIKEPAK 582
            PGA    + +P++ PP S   G     G   P P K  P +     P+   L P  E A 
Sbjct: 960  PGAPMKQAPAPSQ-PPTS--QGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAP 1016

Query: 583  VSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSP 621
               R  +  KP  +    +L   A P    LP     SP
Sbjct: 1017 TVKRTETEKKPPPIKDSKSLT--AEPQKAVLPTKLEKSP 1053



 Score = 38.1 bits (87), Expect = 0.037
 Identities = 55/228 (24%), Positives = 76/228 (33%), Gaps = 47/228 (20%)

Query: 576  PIKEPAKVSPRAAS-PAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQP 634
            P  +    SP  +S PAKP       +L   A PP P  P P    P            P
Sbjct: 2372 PASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPP-----------PP 2420

Query: 635  TAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQD--------RRESLPTS- 685
                PP      P SP     P+ K       +T     +A          R   LP + 
Sbjct: 2421 PPPPPPLP---PPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTR 2477

Query: 686  ------PPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPP--PMSPSWSERSV 737
                  PP  P  S  PS L     P P          S PP+ P P  P  P+ +++  
Sbjct: 2478 ICTTAPPPVPPKPSSIPSGLVFTHRPEP----------SKPPIAPKPVIPQLPTTTQKPT 2527

Query: 738  SPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSP 785
                 +   +P    L + +  N++ +A  K  SP S  + +    SP
Sbjct: 2528 -----DIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSPHSNKSSP 2570



 Score = 33.5 bits (75), Expect = 0.92
 Identities = 67/336 (19%), Positives = 110/336 (32%), Gaps = 37/336 (11%)

Query: 462  QAKPKPKPNQNLSEASGKGAELYARRQSRME------KYVIESSSHTPELARCPSPTMSL 515
            +A P P P ++ S+ +    ++   ++   E      K ++E    T  + + P    + 
Sbjct: 1133 KASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTD 1192

Query: 516  PSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLS 575
                +       A  +  + P            LPE   L PE  K    + +P L    
Sbjct: 1193 QKQEESKLEKDKASALQEKKP------------LPEEKKLIPEEEKIRSEEKKPLLEEKK 1240

Query: 576  PIKEPAKVSPRAASPA-KPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQP 634
            P  E  K+ P A + A +    DL+ +  + A         P     G       + L  
Sbjct: 1241 PTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGL-- 1298

Query: 635  TAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASR 694
                 P G   S        +   K+ P+P  + +   +E    +         T  +S+
Sbjct: 1299 -----PSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDT-SSSQ 1352

Query: 695  PPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPPP-------MSPSWSERSVSPLRPETEAR 747
             P S  G    G    G  SS+   P L P             S+S+ S SP  P   A+
Sbjct: 1353 QPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQES-SPSSPSDLAK 1411

Query: 748  PPSRQLQALLAR--NIINAARRKSASPRSAGAENPR 781
              S  L  L A+   + +    K   P     E P+
Sbjct: 1412 LESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPK 1447



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 36/141 (25%), Positives = 54/141 (38%), Gaps = 18/141 (12%)

Query: 659  KQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSM-- 716
            K    P  + +   +  Q   +S   SP +    S P         P P E G  S +  
Sbjct: 3551 KHISAPEKTYKGGSLGCQTEADSDTQSPQYLSATSPPKDKK----RPTPLEIGYSSHLRA 3606

Query: 717  SSPPPLPPPPPMSPSWSERSVSPLRP----ETEARPPSRQLQALLARNII---NAARRKS 769
             S   L P PP SP      +SPL P    E+   P  + L   ++   +   + A+   
Sbjct: 3607 DSTVQLAPSPPKSPKVLYSPISPLSPGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPP 3666

Query: 770  ASPRSA-----GAENPRPFSP 785
            ASP++A        +P+P SP
Sbjct: 3667 ASPKTAKMMQRSMSDPKPLSP 3687



 Score = 31.6 bits (70), Expect = 3.5
 Identities = 32/135 (23%), Positives = 53/135 (39%), Gaps = 15/135 (11%)

Query: 488  QSRMEKYVIESSSHTPELARCPSP-TMSLPSSWKYPTNAPGAFRVASR-----------S 535
            Q+   +++   +    +L    SP T    SS   PT AP ++   S            S
Sbjct: 3861 QTEFSQFIPPQTQTESQLVPPTSPYTQYQYSSPALPTQAPTSYTQQSHFEQQTLYHQQVS 3920

Query: 536  PARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSS 595
            P +T P       +     ++P PT QP YQL   + V   I++  + +     P   S+
Sbjct: 3921 PYQTQPTFQAVATMSFTPQVQPTPTPQPSYQLPSQMMV---IQQKPRQTTLYLEPKITSN 3977

Query: 596  LDLVPNLPKGALPPS 610
             +++ N P    P S
Sbjct: 3978 YEVIRNQPLMIAPVS 3992


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 117/452 (25%), Positives = 164/452 (36%), Gaps = 96/452 (21%)

Query: 420 PFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGK 479
           PF L +++   Q+E   + +      E+  PE    +K P  Q  PKP P Q      G 
Sbjct: 175 PFDLISDSEASQEETTKKQKV--VQKEQGKPE--GIIKPPLQQQPPKPIPKQQ-----GP 225

Query: 480 GAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPART 539
           G +    +Q    K +   SS  PE  +   P    P                 + P +T
Sbjct: 226 GRD--PLQQDGTPKSI---SSQQPEKIKSQPPGTGKPI----------------QGPTQT 264

Query: 540 PPASLYHGYLP-ENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDL 598
           P     H  LP +    RP+ TKQ            + I     V P   SP+KP     
Sbjct: 265 PQTD--HAKLPLQRDASRPQ-TKQ------------ADIVRGESVKPSLPSPSKPPIQQP 309

Query: 599 VPNLPKGALP------PSPALP--RPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSP 650
            P  P    P      P PA P  +PS  +  L   PG  +++P  V PP G    P  P
Sbjct: 310 TPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPG--TVKPP-VQPP-GTTKPPAQP 365

Query: 651 SRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEP 710
                P A+Q      S+   G +A  +   +  +P   PG ++PP+   G   P   +P
Sbjct: 366 LGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQP 425

Query: 711 GRGSSMSSPPPLPPPPPMSPSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSA 770
           G  S   +P P              + +P++     + P++Q                 A
Sbjct: 426 GLQSPAKAPGP--------------TKTPVQQPGPGKIPAQQ-----------------A 454

Query: 771 SPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQPARPGSAAVPG---AAFAPIPRSP 827
            P    A+   P  PP   P P  PPP  P    P P +PGSA  P     +  P P+ P
Sbjct: 455 GPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQP 514

Query: 828 LPAGPS----SCTSPRSPLPAPPRPFLYRRSP 855
            PA PS      T P S  P   +P   + SP
Sbjct: 515 GPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSP 546



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 184/845 (21%), Positives = 287/845 (33%), Gaps = 128/845 (15%)

Query: 51   QQSSPAPPPAEVHSPAADVNQ-NLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSL 109
            QQ +P  PPA+   P  + +Q   A P A  +  T   +  P        PP T  P + 
Sbjct: 307  QQPTPGKPPAQ--QPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQ 364

Query: 110  PLSSIQQNSSEAQLPSNGTG---PASKPSTLCADGQP----QAPAEEVRCSTLLIDKVST 162
            PL         A+ P+  TG   P+S+     A  QP    + PA++   +     +V T
Sbjct: 365  PLGP-------AKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGT 417

Query: 163  PATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAA--TTPTK 220
            P              P  + PA     +   +  QP    + A Q   G+ +A  T PTK
Sbjct: 418  PKPLAQQ--------PGLQSPAKAPGPTKTPVQ-QPGPGKIPAQQAGPGKTSAQQTGPTK 468

Query: 221  VYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDR 280
              S++    AKPP      A+P   Q PG      + P   +    +  PA   P  P  
Sbjct: 469  PPSQLPGP-AKPPPQQPGPAKP-PPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGS 526

Query: 281  SPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSY 340
            +  P +   S  P  +     Q SPA   +P    +  P  ++T S  PL      PP+ 
Sbjct: 527  TKPPSQQPGSAKPSAQ-----QPSPA---KPSAQQSTKPV-SQTGSGKPL-----QPPTV 572

Query: 341  SVLYPSS-DPKSSHLKGQAVPASKTGILEESMARRGS----RKSMFTFVEKPKVTPNPDL 395
            S   PS+  P S  L     P   T  L   +  + +     +   T        PNP L
Sbjct: 573  S---PSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHL 629

Query: 396  LDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASC 455
             ++ +      + +            ALG + +     P P+ + +P      V      
Sbjct: 630  TEVKEWLCLNCQMKR-----------ALGGDLAPVPSSPQPKLKTAPVTTTSAV------ 672

Query: 456  LKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSL 515
                   +K  P+P Q   +                     + ++   +L++ P P    
Sbjct: 673  -------SKSSPQPQQTSPK---------------------KDAAPKQDLSKAPEPKKP- 703

Query: 516  PSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLS 575
            P   K PT        +  + A+ PP +        + + +P P K+P     PS    +
Sbjct: 704  PPLVKQPT-----LHGSPSAKAKQPPEA--------DSLSKPAPPKEPSV---PSEQDKA 747

Query: 576  PIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPT 635
            P+ +     P+   P    + DLV +      P  P+    S++          DS +P+
Sbjct: 748  PVADDKPKQPKMVKP----TTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPS 803

Query: 636  AVSPPYGGDISPVSPSRAWSPRA--KQAPRPSFSTRNAGIE----AQDRRESLPTSPPWT 689
               PP G  +SP        P +  K    P  S+ + G +     Q + E        +
Sbjct: 804  QSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMS 863

Query: 690  PGASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPPPMSPSWSERSVSPL-RPETEARP 748
            P     P        PGP  P  G ++ +P   P P   S  +S    S    P+++   
Sbjct: 864  PKPDAKPMPKGSPTPPGP-RPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTT 922

Query: 749  PSRQLQALLARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQPA 808
            P   +   L     +   + S    +AG   P   S P AP    P P  PP  + P P 
Sbjct: 923  PQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGP-PK 981

Query: 809  RPGSAAVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAPPRPFLYRRSPTDSD-VSLDSEDS 867
              G A    A   P+ +                 P   R    ++ P   D  SL +E  
Sbjct: 982  STGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQ 1041

Query: 868  GAKSP 872
             A  P
Sbjct: 1042 KAVLP 1046



 Score = 70.9 bits (172), Expect = 5e-12
 Identities = 102/423 (24%), Positives = 150/423 (35%), Gaps = 59/423 (13%)

Query: 401 TADEKRRQRDQGEV-GVEEEPFALGAEASNFQQEPAPRDR----ASPAAAEEVVPEWASC 455
           T  +K  Q++QG+  G+ + P          +Q+   RD      +P +     PE    
Sbjct: 190 TKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPE--KI 247

Query: 456 LKSPRIQAKPKPKPNQNLSEASGK-GAELYARRQSRMEKYVIESSSHTPELARCPSPTMS 514
              P    KP   P Q       K   +  A R    +  ++   S  P L     P + 
Sbjct: 248 KSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQ 307

Query: 515 LPSSWKYPTNAPGAFRVASRSPARTP--PASLYHGYLPENGVLRPEPTKQPPYQLRPSLF 572
            P+  K P   PG  + +   PA+ P  P+ L      + G ++P    QPP   +P   
Sbjct: 308 QPTPGKPPAQQPGHEK-SQPGPAKPPAQPSGLTKPLAQQPGTVKPPV--QPPGTTKPPAQ 364

Query: 573 VLSPIKEPAKVS----PRAASP-----AKPSSLDLVP-NLPKGALPPSPAL--PRPSRSS 620
            L P K PA+ +    P +  P     A+P  +   P   P  A PP+  +  P+P    
Sbjct: 365 PLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQ 424

Query: 621 PGLYTSPGQDSLQPTAVSPPYGGDI--SPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDR 678
           PGL +         T V  P  G I      P +  + +      PS     A    Q  
Sbjct: 425 PGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQP 484

Query: 679 RESLPTSPPWTPGASRPPSSLDGWVSP-----GPWEPGRGSSMSSPPPLPPPPPMSPSWS 733
             + P  PP  PG+++PPS   G   P     GP +P      S+ PP   P    PS  
Sbjct: 485 GPAKP--PPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQ 542

Query: 734 ERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPP 793
           + S         A+P ++Q               K  S   +G    +P  PP   P   
Sbjct: 543 QPS--------PAKPSAQQ-------------STKPVSQTGSG----KPLQPPTVSPSAK 577

Query: 794 PPP 796
            PP
Sbjct: 578 QPP 580



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 124/543 (22%), Positives = 177/543 (32%), Gaps = 106/543 (19%)

Query: 384 VEKPKVTPNPDLLDLVQTADEKRRQRDQGEV--GVEEEPFALGAEASNFQQEPAP----- 436
           ++ P  TP  D   L    D  R Q  Q ++  G   +P +L + +    Q+P P     
Sbjct: 258 IQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKP-SLPSPSKPPIQQPTPGKPPA 316

Query: 437 ----RDRASPAAAEEVVPEWASCLKSPRIQAK-----PKPKPNQNLSEASGKGAELYARR 487
                +++ P  A+   P   S L  P  Q       P   P      A   G      +
Sbjct: 317 QQPGHEKSQPGPAKP--PAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQ 374

Query: 488 QSRMEKYVIESS-----SHTPELARCPS--PTMSLPSSWKYPTNAPGAFRVASRSPARTP 540
           Q+  EK   E       +  P + + P+  P  + P + +  T  P A +   +SPA+ P
Sbjct: 375 QTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAP 434

Query: 541 PASLYHGYLPENGVLRPEPTKQPPYQLRP---SLFVLSPIKEP------AKVSPRAASPA 591
             +       +  V +P P K P  Q  P   S     P K P      AK  P+   PA
Sbjct: 435 GPT-------KTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPA 487

Query: 592 KP---------------SSLDLVPNLPKGALPPSPALP---RPSRSSPG------LYTSP 627
           KP                S    P  P G   PSP  P   +P    PG         SP
Sbjct: 488 KPPPQQPGSAKPPSQQPGSTKPPPQQP-GPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSP 546

Query: 628 GQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPR--------------------PSFS 667
            + S Q +       G   P+ P    SP AKQ P                     P  +
Sbjct: 547 AKPSAQQSTKPVSQTGSGKPLQPPTV-SPSAKQPPSQGLPKTICPLCNTTELLLHVPEKA 605

Query: 668 TRNAGIEAQDRRESLPTSPP---------WTPGASRPPSSLDGWVSPGPWEPGRGSSMSS 718
             N   E Q    SL    P         W     +   +L G ++P P         SS
Sbjct: 606 NFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVP---------SS 656

Query: 719 PPPLPPPPPMSPSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAE 778
           P P     P++ + +    SP   +T  +  +   Q L               P   G+ 
Sbjct: 657 PQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSP 716

Query: 779 NPRPFSPPRAPPPPPPPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCTSP 838
           + +   PP A     P PP  P + S Q   P +   P       P + L +  S+ T P
Sbjct: 717 SAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKP 776

Query: 839 RSP 841
             P
Sbjct: 777 DIP 779



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 66/247 (26%), Positives = 88/247 (35%), Gaps = 62/247 (25%)

Query: 608  PPSP--ALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPS 665
            PPS   ALP   + S   +TS      +  A   P G      SPS +  P     PRP 
Sbjct: 2343 PPSSVIALPMKEQLSTTYFTSGETFGQEKPASQLPSG------SPSVSSLPAK---PRPF 2393

Query: 666  FSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLPPP 725
            F + +  I AQ      P  PP  P    PP                      PPP PPP
Sbjct: 2394 FRSSSLDISAQ------PPPPPPPPPPPPPP----------------------PPPPPPP 2425

Query: 726  PPMSPSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSP 785
            P   P+  + ++ P +  T A P +       A   +      +A  RS G    R  + 
Sbjct: 2426 PLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLET----TAVLRSNGLPVTRICT- 2480

Query: 786  PRAPPPPPPPPPPPPR----MRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCTSPRSP 841
              APPP PP P   P        P+P++P             P +P P  P   T+ + P
Sbjct: 2481 -TAPPPVPPKPSSIPSGLVFTHRPEPSKP-------------PIAPKPVIPQLPTTTQKP 2526

Query: 842  LPAPPRP 848
                P+P
Sbjct: 2527 TDIHPKP 2533



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 134/639 (20%), Positives = 218/639 (34%), Gaps = 113/639 (17%)

Query: 50   AQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSL 109
            AQQ+ P  PP+++  PA    Q    P      P    S  PP    +Q P +T  P   
Sbjct: 461  AQQTGPTKPPSQLPGPAKPPPQ---QPGPAKPPPQQPGSAKPP----SQQPGSTKPPPQQ 513

Query: 110  PLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAE-EVRCSTLLIDKVSTPATTTS 168
            P  +        Q P +   P+ +P +     Q  +PA+   + ST  + +     T + 
Sbjct: 514  PGPA----KPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQ-----TGSG 564

Query: 169  TFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYS----- 223
               +  T+ PS++ P S  +  ++        L++   ++ +        T V S     
Sbjct: 565  KPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFN 624

Query: 224  -EVHFTLAKPPSVVNRTARPF--GIQAPGGTS---QMERSPMLERRHFGEKAPAPQPPSL 277
               H T  K    +N   +    G  AP  +S   +++ +P+       + +P PQ  S 
Sbjct: 625  PNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTS- 683

Query: 278  PDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSP 337
            P +   P++  +S++P  ++     + P     P      PP        AP      S 
Sbjct: 684  PKKDAAPKQD-LSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKE--PSV 740

Query: 338  PSYSVLYPSSDPK--------------------------SSHLKGQA----VPASKTGIL 367
            PS     P +D K                          SS ++ QA     P  KT   
Sbjct: 741  PSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSA 800

Query: 368  E--ESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGA 425
            +  +S    G + S F     P+   +  ++     + E + Q+    V  +EEP     
Sbjct: 801  KPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQT 860

Query: 426  EAS----------NFQQEPAPRDRAS---PAAAEEVVPEWAS---CLKSPRIQAKPKPKP 469
            + S               P PR  A    P   +   P+  S    L    I   PK +P
Sbjct: 861  KMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQP 920

Query: 470  NQNLSEASGK----GAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNA 525
                   +GK    GA ++++            +S+    A  P P         +  + 
Sbjct: 921  TTPQETVTGKLFGFGASIFSQ------------ASNLISTAGQPGP---------HSQSG 959

Query: 526  PGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLR---PSLFVLSPIKEPAK 582
            PGA    + +P++ PP S   G     G   P P K  P +     P+   L P  E A 
Sbjct: 960  PGAPMKQAPAPSQ-PPTS--QGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAP 1016

Query: 583  VSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSP 621
               R  +  KP  +    +L   A P    LP     SP
Sbjct: 1017 TVKRTETEKKPPPIKDSKSLT--AEPQKAVLPTKLEKSP 1053



 Score = 38.1 bits (87), Expect = 0.037
 Identities = 55/228 (24%), Positives = 76/228 (33%), Gaps = 47/228 (20%)

Query: 576  PIKEPAKVSPRAAS-PAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQP 634
            P  +    SP  +S PAKP       +L   A PP P  P P    P            P
Sbjct: 2372 PASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPP-----------PP 2420

Query: 635  TAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQD--------RRESLPTS- 685
                PP      P SP     P+ K       +T     +A          R   LP + 
Sbjct: 2421 PPPPPPLP---PPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTR 2477

Query: 686  ------PPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPP--PMSPSWSERSV 737
                  PP  P  S  PS L     P P          S PP+ P P  P  P+ +++  
Sbjct: 2478 ICTTAPPPVPPKPSSIPSGLVFTHRPEP----------SKPPIAPKPVIPQLPTTTQKPT 2527

Query: 738  SPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSP 785
                 +   +P    L + +  N++ +A  K  SP S  + +    SP
Sbjct: 2528 -----DIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSPHSNKSSP 2570



 Score = 33.5 bits (75), Expect = 0.92
 Identities = 67/336 (19%), Positives = 110/336 (32%), Gaps = 37/336 (11%)

Query: 462  QAKPKPKPNQNLSEASGKGAELYARRQSRME------KYVIESSSHTPELARCPSPTMSL 515
            +A P P P ++ S+ +    ++   ++   E      K ++E    T  + + P    + 
Sbjct: 1133 KASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTD 1192

Query: 516  PSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLS 575
                +       A  +  + P            LPE   L PE  K    + +P L    
Sbjct: 1193 QKQEESKLEKDKASALQEKKP------------LPEEKKLIPEEEKIRSEEKKPLLEEKK 1240

Query: 576  PIKEPAKVSPRAASPA-KPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQP 634
            P  E  K+ P A + A +    DL+ +  + A         P     G       + L  
Sbjct: 1241 PTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGL-- 1298

Query: 635  TAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASR 694
                 P G   S        +   K+ P+P  + +   +E    +         T  +S+
Sbjct: 1299 -----PSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDT-SSSQ 1352

Query: 695  PPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPPP-------MSPSWSERSVSPLRPETEAR 747
             P S  G    G    G  SS+   P L P             S+S+ S SP  P   A+
Sbjct: 1353 QPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQES-SPSSPSDLAK 1411

Query: 748  PPSRQLQALLAR--NIINAARRKSASPRSAGAENPR 781
              S  L  L A+   + +    K   P     E P+
Sbjct: 1412 LESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPK 1447



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 36/141 (25%), Positives = 54/141 (38%), Gaps = 18/141 (12%)

Query: 659  KQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSM-- 716
            K    P  + +   +  Q   +S   SP +    S P         P P E G  S +  
Sbjct: 3551 KHISAPEKTYKGGSLGCQTEADSDTQSPQYLSATSPPKDKK----RPTPLEIGYSSHLRA 3606

Query: 717  SSPPPLPPPPPMSPSWSERSVSPLRP----ETEARPPSRQLQALLARNII---NAARRKS 769
             S   L P PP SP      +SPL P    E+   P  + L   ++   +   + A+   
Sbjct: 3607 DSTVQLAPSPPKSPKVLYSPISPLSPGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPP 3666

Query: 770  ASPRSA-----GAENPRPFSP 785
            ASP++A        +P+P SP
Sbjct: 3667 ASPKTAKMMQRSMSDPKPLSP 3687



 Score = 31.6 bits (70), Expect = 3.5
 Identities = 32/135 (23%), Positives = 53/135 (39%), Gaps = 15/135 (11%)

Query: 488  QSRMEKYVIESSSHTPELARCPSP-TMSLPSSWKYPTNAPGAFRVASR-----------S 535
            Q+   +++   +    +L    SP T    SS   PT AP ++   S            S
Sbjct: 3861 QTEFSQFIPPQTQTESQLVPPTSPYTQYQYSSPALPTQAPTSYTQQSHFEQQTLYHQQVS 3920

Query: 536  PARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSS 595
            P +T P       +     ++P PT QP YQL   + V   I++  + +     P   S+
Sbjct: 3921 PYQTQPTFQAVATMSFTPQVQPTPTPQPSYQLPSQMMV---IQQKPRQTTLYLEPKITSN 3977

Query: 596  LDLVPNLPKGALPPS 610
             +++ N P    P S
Sbjct: 3978 YEVIRNQPLMIAPVS 3992


>gi|116284398 WAS/WASL interacting protein family, member 1 [Homo
           sapiens]
          Length = 503

 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 96/345 (27%), Positives = 123/345 (35%), Gaps = 74/345 (21%)

Query: 522 PTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPA 581
           P + PG F V S      PP    +   P    +  +P   PP           P+  P+
Sbjct: 143 PPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPP-----------PV--PS 189

Query: 582 KVSPRAASPAKPSSLDLVPNLPKGALPPSPA-LPRPSRSSPGLYTSPGQDSLQPTAVSPP 640
              P  +SP    S    P +P G   PSP   P P   + G     G     P + S P
Sbjct: 190 TPRPIQSSPHNRGS----PPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSP 245

Query: 641 YGGDIS-PVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSL 699
           +      P +PSRA   +    P P       G      RE++P  PP     ++PP   
Sbjct: 246 FSNRPPLPPTPSRALDDKPPPPPPP------VGNRPSIHREAVPPPPPQN---NKPPV-- 294

Query: 700 DGWVSPGPWEPGRGSSMSSPPPLPPP-----PPMSPSWSERSVSPLRPETEARPPSRQLQ 754
                  P  P   +S  +PPP PPP     PP+ PS S    +P  P+           
Sbjct: 295 -------PSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQR---------- 337

Query: 755 ALLARNIINAARRKSASPR-SAGAENPRPFSPPRAPPPPP-----------PPPPPPPRM 802
                   N +   S  P  S G   P P  PP   PPPP           PPPPP  R 
Sbjct: 338 --------NLSLSSSTPPLPSPGRSGPLP-PPPSERPPPPVRDPPGRSGPLPPPPPVSRN 388

Query: 803 RSPQPARPGSAAVPGAAFAPIPRS-PLPAGPSSCTSPRSPLPAPP 846
            S   A P +  +P  +    PRS P P  P    S  +P P PP
Sbjct: 389 GSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPP 433



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 40/137 (29%), Positives = 54/137 (39%), Gaps = 17/137 (12%)

Query: 752 QLQALLARNIINAARRKSASPRSAGAENPRPFSPPRAPP--PPPPP-----PPPPPRMRS 804
           +L++   R+  +   R    P    + + +PFSPP  P   P P P     PP P R R 
Sbjct: 110 KLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRM 169

Query: 805 PQPARPGSAAVPGAAFAPIPRSPLP--------AGPSSCTSPRSPLPAP-PRPFLYRRSP 855
           P P RP   + P +   P+P +P P          P     PR P P P P PF   R  
Sbjct: 170 PPP-RPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGT 228

Query: 856 TDSDVSLDSEDSGAKSP 872
                S+      + SP
Sbjct: 229 ALGGGSIRQSPLSSSSP 245



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 109/483 (22%), Positives = 148/483 (30%), Gaps = 117/483 (24%)

Query: 256 RSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNF 315
           R P+L        A    PPS P R P P     S  P  +R  M    P    +P    
Sbjct: 125 RPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIP 184

Query: 316 TAPPTYTETLSTAPLASWVRSPP-SYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARR 374
              P+    + ++P      SPP       PS  P      G    A   G + +S    
Sbjct: 185 PPVPSTPRPIQSSPHNR--GSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSS 242

Query: 375 GSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEP 434
            S      F  +P + P P      +  D+K                            P
Sbjct: 243 SS-----PFSNRPPLPPTPS-----RALDDK-------------------------PPPP 267

Query: 435 APRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKY 494
            P     P+   E VP        P + + P+P        AS +               
Sbjct: 268 PPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRP-------SASSQAPPPPPPPSRPGPPP 320

Query: 495 VIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGV 554
           +  SSS   E  R P   +SL SS   P  +PG                        +G 
Sbjct: 321 LPPSSSGNDETPRLPQRNLSLSSSTP-PLPSPG-----------------------RSGP 356

Query: 555 LRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALP 614
           L P P+++PP           P+++P         P +            G LPP P + 
Sbjct: 357 LPPPPSERPP----------PPVRDP---------PGR-----------SGPLPPPPPVS 386

Query: 615 RPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIE 674
           R   +S  L  +P   S   + V  P  G   P+ P R  S  A   P PS S RN   +
Sbjct: 387 RNGSTSRALPATPQLPS--RSGVDSPRSGPRPPLPPDRP-SAGAPPPPPPSTSIRNGFQD 443

Query: 675 A--QDRRES---------LPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLP 723
           +  +D  ES         LP   P+       PS L    +      G        PPLP
Sbjct: 444 SPCEDEWESRFYFHPISDLPPPEPYVQTTKSYPSKL----ARNESRSGSNRRERGAPPLP 499

Query: 724 PPP 726
           P P
Sbjct: 500 PIP 502



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 48/183 (26%), Positives = 65/183 (35%), Gaps = 42/183 (22%)

Query: 691 GASRPPSSLDGW--VSPGPWEPGRGSSMSSPPPLPPPPPMSPSWSERSVSPLRPETEARP 748
           G SRPP    G    S  P+ P  G     P P P      P      + P RP+  ++P
Sbjct: 122 GGSRPPLLPPGGRSTSAKPFSPPSGPGRF-PVPSPGHRSGPPEPQRNRMPPPRPDVGSKP 180

Query: 749 PSRQLQALLARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQPA 808
            S      +   + +  R   +SP + G+                PP P  PR  SP P 
Sbjct: 181 DS------IPPPVPSTPRPIQSSPHNRGS----------------PPVPGGPRQPSPGPT 218

Query: 809 RP-----GSAAVPGAAFAPIP---------RSPLPAGPSSCTSPRSPLPAPP---RPFLY 851
            P        A+ G +    P         R PLP  PS     + P P PP   RP ++
Sbjct: 219 PPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIH 278

Query: 852 RRS 854
           R +
Sbjct: 279 REA 281



 Score = 32.7 bits (73), Expect = 1.6
 Identities = 26/100 (26%), Positives = 41/100 (41%), Gaps = 7/100 (7%)

Query: 250 GTSQMERSPMLERRHFGEKAPAPQPPS--LPDRSPRPQRHIMSRSPMVERRMMGQRSPAS 307
           G   + +SP+     F  + P P  PS  L D+ P P   + +R P + R  +    P +
Sbjct: 231 GGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNR-PSIHREAVPPPPPQN 289

Query: 308 ERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSS 347
            + P+ +   P   ++     P  S    PP    L PSS
Sbjct: 290 NKPPVPSTPRPSASSQAPPPPPPPSRPGPPP----LPPSS 325



 Score = 31.2 bits (69), Expect = 4.5
 Identities = 11/22 (50%), Positives = 12/22 (54%)

Query: 789 PPPPPPPPPPPPRMRSPQPARP 810
           P PPPP PPPPP        +P
Sbjct: 2   PVPPPPAPPPPPTFALANTEKP 23



 Score = 30.4 bits (67), Expect = 7.8
 Identities = 28/102 (27%), Positives = 40/102 (39%), Gaps = 17/102 (16%)

Query: 50  AQQSSPAPPP------AEVHSPAA--DVNQNLASPSATLTTPTSNSSHNPPATDVNQNPP 101
           A    P PPP        +H  A      QN   P  +   P+++S   PP    ++  P
Sbjct: 259 ALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGP 318

Query: 102 ATVVPQS--------LPLSSIQQNSSEAQLPSNG-TGPASKP 134
             + P S        LP  ++  +SS   LPS G +GP   P
Sbjct: 319 PPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPP 360


>gi|38373695 WAS/WASL interacting protein family, member 1 [Homo
           sapiens]
          Length = 503

 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 96/345 (27%), Positives = 123/345 (35%), Gaps = 74/345 (21%)

Query: 522 PTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPA 581
           P + PG F V S      PP    +   P    +  +P   PP           P+  P+
Sbjct: 143 PPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPP-----------PV--PS 189

Query: 582 KVSPRAASPAKPSSLDLVPNLPKGALPPSPA-LPRPSRSSPGLYTSPGQDSLQPTAVSPP 640
              P  +SP    S    P +P G   PSP   P P   + G     G     P + S P
Sbjct: 190 TPRPIQSSPHNRGS----PPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSP 245

Query: 641 YGGDIS-PVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSL 699
           +      P +PSRA   +    P P       G      RE++P  PP     ++PP   
Sbjct: 246 FSNRPPLPPTPSRALDDKPPPPPPP------VGNRPSIHREAVPPPPPQN---NKPPV-- 294

Query: 700 DGWVSPGPWEPGRGSSMSSPPPLPPP-----PPMSPSWSERSVSPLRPETEARPPSRQLQ 754
                  P  P   +S  +PPP PPP     PP+ PS S    +P  P+           
Sbjct: 295 -------PSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQR---------- 337

Query: 755 ALLARNIINAARRKSASPR-SAGAENPRPFSPPRAPPPPP-----------PPPPPPPRM 802
                   N +   S  P  S G   P P  PP   PPPP           PPPPP  R 
Sbjct: 338 --------NLSLSSSTPPLPSPGRSGPLP-PPPSERPPPPVRDPPGRSGPLPPPPPVSRN 388

Query: 803 RSPQPARPGSAAVPGAAFAPIPRS-PLPAGPSSCTSPRSPLPAPP 846
            S   A P +  +P  +    PRS P P  P    S  +P P PP
Sbjct: 389 GSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPP 433



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 40/137 (29%), Positives = 54/137 (39%), Gaps = 17/137 (12%)

Query: 752 QLQALLARNIINAARRKSASPRSAGAENPRPFSPPRAPP--PPPPP-----PPPPPRMRS 804
           +L++   R+  +   R    P    + + +PFSPP  P   P P P     PP P R R 
Sbjct: 110 KLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRM 169

Query: 805 PQPARPGSAAVPGAAFAPIPRSPLP--------AGPSSCTSPRSPLPAP-PRPFLYRRSP 855
           P P RP   + P +   P+P +P P          P     PR P P P P PF   R  
Sbjct: 170 PPP-RPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGT 228

Query: 856 TDSDVSLDSEDSGAKSP 872
                S+      + SP
Sbjct: 229 ALGGGSIRQSPLSSSSP 245



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 109/483 (22%), Positives = 148/483 (30%), Gaps = 117/483 (24%)

Query: 256 RSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNF 315
           R P+L        A    PPS P R P P     S  P  +R  M    P    +P    
Sbjct: 125 RPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIP 184

Query: 316 TAPPTYTETLSTAPLASWVRSPP-SYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARR 374
              P+    + ++P      SPP       PS  P      G    A   G + +S    
Sbjct: 185 PPVPSTPRPIQSSPHNR--GSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSS 242

Query: 375 GSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEP 434
            S      F  +P + P P      +  D+K                            P
Sbjct: 243 SS-----PFSNRPPLPPTPS-----RALDDK-------------------------PPPP 267

Query: 435 APRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKY 494
            P     P+   E VP        P + + P+P        AS +               
Sbjct: 268 PPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRP-------SASSQAPPPPPPPSRPGPPP 320

Query: 495 VIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGV 554
           +  SSS   E  R P   +SL SS   P  +PG                        +G 
Sbjct: 321 LPPSSSGNDETPRLPQRNLSLSSSTP-PLPSPG-----------------------RSGP 356

Query: 555 LRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALP 614
           L P P+++PP           P+++P         P +            G LPP P + 
Sbjct: 357 LPPPPSERPP----------PPVRDP---------PGR-----------SGPLPPPPPVS 386

Query: 615 RPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIE 674
           R   +S  L  +P   S   + V  P  G   P+ P R  S  A   P PS S RN   +
Sbjct: 387 RNGSTSRALPATPQLPS--RSGVDSPRSGPRPPLPPDRP-SAGAPPPPPPSTSIRNGFQD 443

Query: 675 A--QDRRES---------LPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLP 723
           +  +D  ES         LP   P+       PS L    +      G        PPLP
Sbjct: 444 SPCEDEWESRFYFHPISDLPPPEPYVQTTKSYPSKL----ARNESRSGSNRRERGAPPLP 499

Query: 724 PPP 726
           P P
Sbjct: 500 PIP 502



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 48/183 (26%), Positives = 65/183 (35%), Gaps = 42/183 (22%)

Query: 691 GASRPPSSLDGW--VSPGPWEPGRGSSMSSPPPLPPPPPMSPSWSERSVSPLRPETEARP 748
           G SRPP    G    S  P+ P  G     P P P      P      + P RP+  ++P
Sbjct: 122 GGSRPPLLPPGGRSTSAKPFSPPSGPGRF-PVPSPGHRSGPPEPQRNRMPPPRPDVGSKP 180

Query: 749 PSRQLQALLARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQPA 808
            S      +   + +  R   +SP + G+                PP P  PR  SP P 
Sbjct: 181 DS------IPPPVPSTPRPIQSSPHNRGS----------------PPVPGGPRQPSPGPT 218

Query: 809 RP-----GSAAVPGAAFAPIP---------RSPLPAGPSSCTSPRSPLPAPP---RPFLY 851
            P        A+ G +    P         R PLP  PS     + P P PP   RP ++
Sbjct: 219 PPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIH 278

Query: 852 RRS 854
           R +
Sbjct: 279 REA 281



 Score = 32.7 bits (73), Expect = 1.6
 Identities = 26/100 (26%), Positives = 41/100 (41%), Gaps = 7/100 (7%)

Query: 250 GTSQMERSPMLERRHFGEKAPAPQPPS--LPDRSPRPQRHIMSRSPMVERRMMGQRSPAS 307
           G   + +SP+     F  + P P  PS  L D+ P P   + +R P + R  +    P +
Sbjct: 231 GGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNR-PSIHREAVPPPPPQN 289

Query: 308 ERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSS 347
            + P+ +   P   ++     P  S    PP    L PSS
Sbjct: 290 NKPPVPSTPRPSASSQAPPPPPPPSRPGPPP----LPPSS 325



 Score = 31.2 bits (69), Expect = 4.5
 Identities = 11/22 (50%), Positives = 12/22 (54%)

Query: 789 PPPPPPPPPPPPRMRSPQPARP 810
           P PPPP PPPPP        +P
Sbjct: 2   PVPPPPAPPPPPTFALANTEKP 23



 Score = 30.4 bits (67), Expect = 7.8
 Identities = 28/102 (27%), Positives = 40/102 (39%), Gaps = 17/102 (16%)

Query: 50  AQQSSPAPPP------AEVHSPAA--DVNQNLASPSATLTTPTSNSSHNPPATDVNQNPP 101
           A    P PPP        +H  A      QN   P  +   P+++S   PP    ++  P
Sbjct: 259 ALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGP 318

Query: 102 ATVVPQS--------LPLSSIQQNSSEAQLPSNG-TGPASKP 134
             + P S        LP  ++  +SS   LPS G +GP   P
Sbjct: 319 PPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPP 360


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 87.0 bits (214), Expect = 7e-17
 Identities = 106/482 (21%), Positives = 183/482 (37%), Gaps = 60/482 (12%)

Query: 386 KPKVTPNPDLL-DLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAA 444
           +P + PN D   +   T +++     +      ++    G E +   +E    ++ S   
Sbjct: 127 RPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTS--- 183

Query: 445 AEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPE 504
           A+++ P       + ++ AKP PK     +E + KG  L   ++        E +S TP+
Sbjct: 184 AKDLAP-------TSKVLAKPTPK-----AETTTKGPALTTPKEPTPTTPK-EPASTTPK 230

Query: 505 LARCPSPTM--SLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQ 562
               P+PT   S P++ K P  AP   + A  +P    P +             P  TK+
Sbjct: 231 E---PTPTTIKSAPTTPKEP--APTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKE 285

Query: 563 PPYQLRPSLFVLSPI--KEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSS 620
           P     P+    +P   KEPA  +P+  +P  P   +  P  PK   P +P  P P+   
Sbjct: 286 PA----PTTTKSAPTTPKEPAPTTPKKPAPTTPK--EPAPTTPKEPTPTTPKEPAPTTKE 339

Query: 621 PGLYTSPGQDSLQPTAVSPPYGGDISPVSP-------SRAWSPRAKQAPRPSFSTRNAGI 673
           P   T        P   +P    + +P +P       ++  SP   + P P+ +T++A  
Sbjct: 340 PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPT-TTKSAPT 398

Query: 674 EAQDRRESLPTSPPWTPGASRPPSSLDGWVS----PGPWEPGRGSSMSSPPPLPPPPPMS 729
             ++   +   S P TP    P ++ +   +    P P  P + +  +   P P  P   
Sbjct: 399 TTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP 458

Query: 730 PSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSP---- 785
              + +  +P  P+  A    ++      + +      K A       E P P +P    
Sbjct: 459 APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTP---EKPAPTTPEELA 515

Query: 786 PRAPPPPPPPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAP 845
           P  P  P P  P  P   +P+ A P +   P       P+ P P      T+P+ P P  
Sbjct: 516 PTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPT---TPKEPAP------TTPKEPAPTT 566

Query: 846 PR 847
           P+
Sbjct: 567 PK 568



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 98/470 (20%), Positives = 163/470 (34%), Gaps = 53/470 (11%)

Query: 432 QEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKP------KPKPNQNLSEASGKGAELYA 485
           +EPAP     PA      P   +   +P    +P      KP P      A     E   
Sbjct: 268 KEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTP 327

Query: 486 RRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLY 545
                      E +  TP+     +P    P++ K P  AP   +  + +  + P  +  
Sbjct: 328 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEP--APTTPKEPAPTTTKEPSPTTP 385

Query: 546 HGYLPENGVLRPEPTKQPPYQLRPSLFVL------SPIKEPAKVSPRAASPAKPSSLDLV 599
               P      P  TK+P      S          +  KEPA  +P+  +P  P      
Sbjct: 386 KEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKP--A 443

Query: 600 PNLPKGALPPSPALPRPSRSSPGLYTSPGQDS-LQPTAVSPPYGGDISPVSPSRAWSPRA 658
           P  PK   P +P  P P+ +     T+P + +   P   +P     ++P +P +  +P  
Sbjct: 444 PTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKL-APTT 502

Query: 659 KQAPRPSFSTRNAGIEAQDRRESLPTSP-PWTPGASRPPSSLDGWVSPGPWEPGRGSSMS 717
            + P P+     A    ++   + P  P P TP A+ P +  +    P P  P   +  +
Sbjct: 503 PEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE----PAPTTPKEPAPTT 558

Query: 718 SPPPLPPPPPMSPSWSERSVSPLR-----PETEARPPSRQLQALLARNIINAARRKSA-- 770
              P P  P  +   + +  +P       P T  +P  ++L     +   +    K A  
Sbjct: 559 PKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPT 618

Query: 771 SPRSAGAENPRPFSP--PRAPPPPPP---------------PPPPPPRMRSPQPARPGSA 813
           +P+      P+  +P  P+ P P  P               P  P P+  +P   +  ++
Sbjct: 619 TPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTS 678

Query: 814 AVPGAAFAPIPRSPLPAGPS--SCTSPRSPLPAPPRPFLYRRSPTDSDVS 861
                     P+   P  P   + T+P+ P P  P        PT S+VS
Sbjct: 679 TTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPE----TPPPTTSEVS 724



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 159/772 (20%), Positives = 246/772 (31%), Gaps = 77/772 (9%)

Query: 46  QNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTP-TSNSSHNPPATDVNQNPPATV 104
           +NR  ++ +P PP  +      +    L +    +TTP TS + HN  +T         +
Sbjct: 71  KNRTKKKPTPKPPVVD------EAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPI 124

Query: 105 VPQ-SLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTP 163
            P+ SLP +S    S E  L  N         T   + Q     +E   +T   +  S  
Sbjct: 125 NPRPSLPPNS--DTSKETSLTVNKETTVETKETTTTNKQTSTDGKEK--TTSAKETQSIE 180

Query: 164 ATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYS 223
            T+    +  + ++    P A        L   +  T   +  +  S      TPT + S
Sbjct: 181 KTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPT-PTTPKEPASTTPKEPTPTTIKS 239

Query: 224 EVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPR 283
               T  K P+     + P   + P  T+  E +P         K PAP     P  +  
Sbjct: 240 AP--TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTT------PKEPAPTTTKEPAPTTT 291

Query: 284 PQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVL 343
                  + P          +P + ++P     AP T  E   T P      +P   +  
Sbjct: 292 KSAPTTPKEP----------APTTPKKP-----APTTPKEPAPTTPKEPTPTTPKEPAPT 336

Query: 344 YPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVT----PNPDLLDLV 399
                P +        P        +  A    ++   T  ++P  T    P P      
Sbjct: 337 TKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSA 396

Query: 400 QTADEK---RRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCL 456
            T  ++      +       E  P      A    +EPAP     PA      P   +  
Sbjct: 397 PTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA-PTTP 455

Query: 457 KSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIES-SSHTPELARCPSPTMSL 515
           K P      KP P      A     E       ++     E  +  TPE     +P    
Sbjct: 456 KEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELA 515

Query: 516 PSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLS 575
           P++ + PT            PA T P +        N    P PT   P +  P+    +
Sbjct: 516 PTTPEEPT------PTTPEEPAPTTPKA-----AAPNTPKEPAPT--TPKEPAPT----T 558

Query: 576 PIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPT 635
           P KEPA  +P+  +P  P      P   K   P +P  P P   +P     P   +    
Sbjct: 559 P-KEPAPTTPKETAPTTPKG--TAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP 615

Query: 636 AVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRP 695
           A + P G   +P +P    +P   + P P   T   G      +E  PT+P         
Sbjct: 616 APTTPKG--TAPTTPKEP-APTTPKEPAP---TTPKGTAPTTLKEPAPTTPKKPAPKELA 669

Query: 696 PSSLDGWVSPGPWEPGRGSSMSSPPPLP-PPPPMSPSWSERSVSPLRPETEARPPSRQLQ 754
           P++  G  S    +P   +   + P  P  P P +P    +  +P  PET     S    
Sbjct: 670 PTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTP----KKPAPTTPETPPPTTSEVST 725

Query: 755 ALLARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQ 806
               +      +    S     AE P P +   +P  P  P    P    P+
Sbjct: 726 PTTTKEPTTIHKSPDESTPELSAE-PTPKALENSPKEPGVPTTKTPAATKPE 776



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 98/482 (20%), Positives = 155/482 (32%), Gaps = 50/482 (10%)

Query: 386 KPKVTPNPDLLD-----------LVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEP 434
           K K TP P ++D            V T D    Q ++    V   P    A+  N +   
Sbjct: 75  KKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNK----VSTSPKITTAKPINPRPSL 130

Query: 435 APRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKY 494
            P    S   +  V        K   ++ K     N+  S   GK     A+    +EK 
Sbjct: 131 PPNSDTSKETSLTVN-------KETTVETKETTTTNKQTS-TDGKEKTTSAKETQSIEKT 182

Query: 495 VIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGV 554
             +  + T ++   P+P     +     T          + PA T P       +     
Sbjct: 183 SAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPT 242

Query: 555 L--RPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAK-----PSSLDLVPNLPKGAL 607
               P PT        P     +  KEPA  +P+  +P       P++    P  PK   
Sbjct: 243 TPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPA 302

Query: 608 PPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFS 667
           P +P  P P+       T+P +    PT  +P       P   ++  +P   + P P+  
Sbjct: 303 PTTPKKPAPTTPKEPAPTTPKE----PTPTTPK-----EPAPTTKEPAPTTPKEPAPTAP 353

Query: 668 TRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPPP 727
            + A    ++   + P  P   P  ++ PS         P EP   ++ S+P     P P
Sbjct: 354 KKPAPTTPKEPAPTTPKEP--APTTTKEPSPTT------PKEPAPTTTKSAPTTTKEPAP 405

Query: 728 MSPSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSPPR 787
            +   +  +     P T   P     +          A      P     + P P +  +
Sbjct: 406 TTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 465

Query: 788 -APPPPPPPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSC--TSPRSPLPA 844
            AP  P  P P  P+  +P   +  +   P       P  P P  P     T+P  P P 
Sbjct: 466 PAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPT 525

Query: 845 PP 846
            P
Sbjct: 526 TP 527



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 171/866 (19%), Positives = 272/866 (31%), Gaps = 120/866 (13%)

Query: 5   SEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAEVHS 64
           S+E SL  + E     +E          +    T +        +      AP    +  
Sbjct: 137 SKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAK 196

Query: 65  PAADVNQNLASPSATLTT-PTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSEAQL 123
           P          P+ T    PT  +   P +T   +  P T+  +S P +   +  +    
Sbjct: 197 PTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTI--KSAPTTP--KEPAPTTT 252

Query: 124 PSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTS--TFSREATLIPSSR 181
            S  T P     T   +  P  P E    +T    K   P TT S  T  +E       +
Sbjct: 253 KSAPTTPKEPAPTTTKEPAPTTPKEPAPTTT----KEPAPTTTKSAPTTPKEPAPTTPKK 308

Query: 182 PPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTAR 241
           P  +     +     +P           +   A TTP +          KP     +   
Sbjct: 309 PAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAP---KKPAPTTPKEPA 365

Query: 242 PFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPP-SLPDRSPRPQRHIMSRSPMVERRMM 300
           P   + P  T+  E SP         K PAP    S P  +  P       +P   +   
Sbjct: 366 PTTPKEPAPTTTKEPSPTTP------KEPAPTTTKSAPTTTKEPAPTTTKSAPTTPK--- 416

Query: 301 GQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSD----PKSSHLKG 356
            + SP + + P       P  T     AP      +P +     P++     P +     
Sbjct: 417 -EPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPA 475

Query: 357 QAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGV 416
              P        + +      K   T  EKP  T   +L     T +E      +     
Sbjct: 476 PTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPT--TPEEPTPTTPE----- 528

Query: 417 EEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEA 476
           E  P    A A N  +EPAP     PA               P    +P P   +  +  
Sbjct: 529 EPAPTTPKAAAPNTPKEPAPTTPKEPA---------------PTTPKEPAPTTPKETAPT 573

Query: 477 SGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSP 536
           + KG      ++              P   + P+P    P++ K PT+           P
Sbjct: 574 TPKGTAPTTLKEP------------APTTPKKPAPKELAPTTTKEPTST------TCDKP 615

Query: 537 ARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSL 596
           A T P     G  P         T + P    P     + +KEPA  +P+     KP+  
Sbjct: 616 APTTPK----GTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPK-----KPAPK 666

Query: 597 DLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSP 656
           +L P   KG  P S    +P+ ++P            PT    P     +P +P +  +P
Sbjct: 667 ELAPTTTKG--PTSTTSDKPAPTTP--------KETAPTTPKEP-----APTTPKKP-AP 710

Query: 657 RAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGW---VSPGPWEPGRG 713
              + P P+ S  +     ++     PT+   +P  S P  S +     +   P EPG  
Sbjct: 711 TTPETPPPTTSEVSTPTTTKE-----PTTIHKSPDESTPELSAEPTPKALENSPKEPGVP 765

Query: 714 SSMSSPPPLPPPPPMSPSWSERSVS-PLR--PETEARPP--SRQLQALLARNIINAARRK 768
           ++ +   P    P M+ +  +++    LR  PET    P  +++      +   +     
Sbjct: 766 TTKT---PAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITAT 822

Query: 769 SASPRSAGAENPRPFSPPRAPPPPPPPPPPPPR--------MRSP-QPARPGSAAVPGAA 819
           +    S   ++  PF           P     +        M  P + A+P   A    A
Sbjct: 823 TTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKA 882

Query: 820 FAPIPRSPLPAGPSSCTSPRSPLPAP 845
             P P+ P  A P   TS + P   P
Sbjct: 883 TTPKPQKPTKA-PKKPTSTKKPKTMP 907



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 45/205 (21%), Positives = 65/205 (31%), Gaps = 13/205 (6%)

Query: 662 PRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGS--SMSSP 719
           P P   T   G      +E  PT+P   P ++ P       +   P  P   +  +  S 
Sbjct: 197 PTPKAETTTKGPALTTPKEPTPTTPK-EPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSA 255

Query: 720 PPLPPPPPMSPSWSERSVSPLRPE-TEARPPSRQLQALLARNIINAARRKSASPRSAGAE 778
           P  P  P  + +      +P  P  T  + P+              A      P     +
Sbjct: 256 PTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPK 315

Query: 779 NPRPFSPPRAPPPPPPPPPPPPRMRSPQPARPGSAA--VPGAAFAPIPRSPLPA-----G 831
            P P +P    P P  P  P P  + P P  P   A   P       P+ P P       
Sbjct: 316 EPAPTTPKE--PTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPA 373

Query: 832 PSSCTSPRSPLPAPPRPFLYRRSPT 856
           P++   P    P  P P   + +PT
Sbjct: 374 PTTTKEPSPTTPKEPAPTTTKSAPT 398



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 46/251 (18%), Positives = 86/251 (34%), Gaps = 17/251 (6%)

Query: 609 PSPALPRPSRSSPGL------YTSPGQDSLQPTAVSP-PYGGDISPVSPSRAWSPRAKQA 661
           P+P  P    +  GL       T+P   + Q   VS  P      P++P  +  P +  +
Sbjct: 78  PTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTS 137

Query: 662 PRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGW----VSPGPWEPGRGSSMS 717
              S  T N     + +  +       T G  +  S+ +       S     P     ++
Sbjct: 138 KETSL-TVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAP-TSKVLA 195

Query: 718 SPPPLPPPPPMSPSWSE-RSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAG 776
            P P        P+ +  +  +P  P+  A    ++      ++     +  + +   + 
Sbjct: 196 KPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSA 255

Query: 777 AENPRPFSPPRAPPPPPPPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCT 836
              P+  +P     P P  P  P    + +PA   + + P     P P +P    P   T
Sbjct: 256 PTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAP---T 312

Query: 837 SPRSPLPAPPR 847
           +P+ P P  P+
Sbjct: 313 TPKEPAPTTPK 323



 Score = 38.9 bits (89), Expect = 0.022
 Identities = 108/569 (18%), Positives = 183/569 (32%), Gaps = 116/569 (20%)

Query: 50  AQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSL 109
           A  ++  P P     PA    +  A  +    TPT+     P   +     PA   P+ L
Sbjct: 459 APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPE----KPAPTTPEEL 514

Query: 110 -PLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTS 168
            P +  +   +  + P+  T  A+ P+T      P+ PA             +TP     
Sbjct: 515 APTTPEEPTPTTPEEPAPTTPKAAAPNT------PKEPAP------------TTPKEPAP 556

Query: 169 TFSREA--TLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVH 226
           T  +E   T    + P      + + L +  P T    A +E++       PT       
Sbjct: 557 TTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELA-------PTTTKEPTS 609

Query: 227 FTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGE--KAPAPQPPSLPDRSPRP 284
            T  KP     +   P   + P  T+  E +P   +       K PAP  P    + P P
Sbjct: 610 TTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTP----KKPAP 665

Query: 285 QRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLY 344
           +        +      G  S  S++       AP T  ET  T P      +P   +   
Sbjct: 666 KE-------LAPTTTKGPTSTTSDK------PAPTTPKETAPTTPKEPAPTTPKKPAPTT 712

Query: 345 PSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADE 404
           P + P ++                             + V  P  T  P       T   
Sbjct: 713 PETPPPTT-----------------------------SEVSTPTTTKEP-------TTIH 736

Query: 405 KRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAK 464
           K       E+  E  P AL     N  +EP      +PAA +   PE  +  K    +  
Sbjct: 737 KSPDESTPELSAEPTPKAL----ENSPKEPGVPTTKTPAATK---PEMTTTAKDKTTERD 789

Query: 465 PKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTN 524
            +  P    +               +M K    ++  T E ++  + T  + S+    T 
Sbjct: 790 LRTTPETTTAAP-------------KMTKETATTTEKTTE-SKITATTTQVTSTTTQDTT 835

Query: 525 APGAFRVAS-RSPARTPPASLYHGYLPENGVL-RPEPTKQPPYQLRPSLFVLSPIKEPAK 582
               F++ + ++    P  +     +    ++ +PE T +P  +   S       ++P K
Sbjct: 836 P---FKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTK 892

Query: 583 VSPRAASPAKPSSLDLVPNLPKGALPPSP 611
              +  S  KP ++   P + K    P+P
Sbjct: 893 APKKPTSTKKPKTM---PRVRKPKTTPTP 918


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 87.0 bits (214), Expect = 7e-17
 Identities = 106/482 (21%), Positives = 183/482 (37%), Gaps = 60/482 (12%)

Query: 386 KPKVTPNPDLL-DLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAA 444
           +P + PN D   +   T +++     +      ++    G E +   +E    ++ S   
Sbjct: 168 RPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTS--- 224

Query: 445 AEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPE 504
           A+++ P       + ++ AKP PK     +E + KG  L   ++        E +S TP+
Sbjct: 225 AKDLAP-------TSKVLAKPTPK-----AETTTKGPALTTPKEPTPTTPK-EPASTTPK 271

Query: 505 LARCPSPTM--SLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQ 562
               P+PT   S P++ K P  AP   + A  +P    P +             P  TK+
Sbjct: 272 E---PTPTTIKSAPTTPKEP--APTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKE 326

Query: 563 PPYQLRPSLFVLSPI--KEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSS 620
           P     P+    +P   KEPA  +P+  +P  P   +  P  PK   P +P  P P+   
Sbjct: 327 PA----PTTTKSAPTTPKEPAPTTPKKPAPTTPK--EPAPTTPKEPTPTTPKEPAPTTKE 380

Query: 621 PGLYTSPGQDSLQPTAVSPPYGGDISPVSP-------SRAWSPRAKQAPRPSFSTRNAGI 673
           P   T        P   +P    + +P +P       ++  SP   + P P+ +T++A  
Sbjct: 381 PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPT-TTKSAPT 439

Query: 674 EAQDRRESLPTSPPWTPGASRPPSSLDGWVS----PGPWEPGRGSSMSSPPPLPPPPPMS 729
             ++   +   S P TP    P ++ +   +    P P  P + +  +   P P  P   
Sbjct: 440 TTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP 499

Query: 730 PSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSP---- 785
              + +  +P  P+  A    ++      + +      K A       E P P +P    
Sbjct: 500 APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTP---EKPAPTTPEELA 556

Query: 786 PRAPPPPPPPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAP 845
           P  P  P P  P  P   +P+ A P +   P       P+ P P      T+P+ P P  
Sbjct: 557 PTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPT---TPKEPAP------TTPKEPAPTT 607

Query: 846 PR 847
           P+
Sbjct: 608 PK 609



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 98/470 (20%), Positives = 163/470 (34%), Gaps = 53/470 (11%)

Query: 432 QEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKP------KPKPNQNLSEASGKGAELYA 485
           +EPAP     PA      P   +   +P    +P      KP P      A     E   
Sbjct: 309 KEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTP 368

Query: 486 RRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLY 545
                      E +  TP+     +P    P++ K P  AP   +  + +  + P  +  
Sbjct: 369 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEP--APTTPKEPAPTTTKEPSPTTP 426

Query: 546 HGYLPENGVLRPEPTKQPPYQLRPSLFVL------SPIKEPAKVSPRAASPAKPSSLDLV 599
               P      P  TK+P      S          +  KEPA  +P+  +P  P      
Sbjct: 427 KEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKP--A 484

Query: 600 PNLPKGALPPSPALPRPSRSSPGLYTSPGQDS-LQPTAVSPPYGGDISPVSPSRAWSPRA 658
           P  PK   P +P  P P+ +     T+P + +   P   +P     ++P +P +  +P  
Sbjct: 485 PTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKL-APTT 543

Query: 659 KQAPRPSFSTRNAGIEAQDRRESLPTSP-PWTPGASRPPSSLDGWVSPGPWEPGRGSSMS 717
            + P P+     A    ++   + P  P P TP A+ P +  +    P P  P   +  +
Sbjct: 544 PEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE----PAPTTPKEPAPTT 599

Query: 718 SPPPLPPPPPMSPSWSERSVSPLR-----PETEARPPSRQLQALLARNIINAARRKSA-- 770
              P P  P  +   + +  +P       P T  +P  ++L     +   +    K A  
Sbjct: 600 PKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPT 659

Query: 771 SPRSAGAENPRPFSP--PRAPPPPPP---------------PPPPPPRMRSPQPARPGSA 813
           +P+      P+  +P  P+ P P  P               P  P P+  +P   +  ++
Sbjct: 660 TPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTS 719

Query: 814 AVPGAAFAPIPRSPLPAGPS--SCTSPRSPLPAPPRPFLYRRSPTDSDVS 861
                     P+   P  P   + T+P+ P P  P        PT S+VS
Sbjct: 720 TTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPE----TPPPTTSEVS 765



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 159/772 (20%), Positives = 246/772 (31%), Gaps = 77/772 (9%)

Query: 46  QNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTP-TSNSSHNPPATDVNQNPPATV 104
           +NR  ++ +P PP  +      +    L +    +TTP TS + HN  +T         +
Sbjct: 112 KNRTKKKPTPKPPVVD------EAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPI 165

Query: 105 VPQ-SLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTP 163
            P+ SLP +S    S E  L  N         T   + Q     +E   +T   +  S  
Sbjct: 166 NPRPSLPPNS--DTSKETSLTVNKETTVETKETTTTNKQTSTDGKEK--TTSAKETQSIE 221

Query: 164 ATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYS 223
            T+    +  + ++    P A        L   +  T   +  +  S      TPT + S
Sbjct: 222 KTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPT-PTTPKEPASTTPKEPTPTTIKS 280

Query: 224 EVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPR 283
               T  K P+     + P   + P  T+  E +P         K PAP     P  +  
Sbjct: 281 AP--TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTT------PKEPAPTTTKEPAPTTT 332

Query: 284 PQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVL 343
                  + P          +P + ++P     AP T  E   T P      +P   +  
Sbjct: 333 KSAPTTPKEP----------APTTPKKP-----APTTPKEPAPTTPKEPTPTTPKEPAPT 377

Query: 344 YPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVT----PNPDLLDLV 399
                P +        P        +  A    ++   T  ++P  T    P P      
Sbjct: 378 TKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSA 437

Query: 400 QTADEK---RRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCL 456
            T  ++      +       E  P      A    +EPAP     PA      P   +  
Sbjct: 438 PTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA-PTTP 496

Query: 457 KSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIES-SSHTPELARCPSPTMSL 515
           K P      KP P      A     E       ++     E  +  TPE     +P    
Sbjct: 497 KEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELA 556

Query: 516 PSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLS 575
           P++ + PT            PA T P +        N    P PT   P +  P+    +
Sbjct: 557 PTTPEEPT------PTTPEEPAPTTPKA-----AAPNTPKEPAPT--TPKEPAPT----T 599

Query: 576 PIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPT 635
           P KEPA  +P+  +P  P      P   K   P +P  P P   +P     P   +    
Sbjct: 600 P-KEPAPTTPKETAPTTPKG--TAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP 656

Query: 636 AVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRP 695
           A + P G   +P +P    +P   + P P   T   G      +E  PT+P         
Sbjct: 657 APTTPKG--TAPTTPKEP-APTTPKEPAP---TTPKGTAPTTLKEPAPTTPKKPAPKELA 710

Query: 696 PSSLDGWVSPGPWEPGRGSSMSSPPPLP-PPPPMSPSWSERSVSPLRPETEARPPSRQLQ 754
           P++  G  S    +P   +   + P  P  P P +P    +  +P  PET     S    
Sbjct: 711 PTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTP----KKPAPTTPETPPPTTSEVST 766

Query: 755 ALLARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQ 806
               +      +    S     AE P P +   +P  P  P    P    P+
Sbjct: 767 PTTTKEPTTIHKSPDESTPELSAE-PTPKALENSPKEPGVPTTKTPAATKPE 817



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 98/482 (20%), Positives = 155/482 (32%), Gaps = 50/482 (10%)

Query: 386 KPKVTPNPDLLD-----------LVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEP 434
           K K TP P ++D            V T D    Q ++    V   P    A+  N +   
Sbjct: 116 KKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNK----VSTSPKITTAKPINPRPSL 171

Query: 435 APRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKY 494
            P    S   +  V        K   ++ K     N+  S   GK     A+    +EK 
Sbjct: 172 PPNSDTSKETSLTVN-------KETTVETKETTTTNKQTS-TDGKEKTTSAKETQSIEKT 223

Query: 495 VIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGV 554
             +  + T ++   P+P     +     T          + PA T P       +     
Sbjct: 224 SAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPT 283

Query: 555 L--RPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAK-----PSSLDLVPNLPKGAL 607
               P PT        P     +  KEPA  +P+  +P       P++    P  PK   
Sbjct: 284 TPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPA 343

Query: 608 PPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFS 667
           P +P  P P+       T+P +    PT  +P       P   ++  +P   + P P+  
Sbjct: 344 PTTPKKPAPTTPKEPAPTTPKE----PTPTTPK-----EPAPTTKEPAPTTPKEPAPTAP 394

Query: 668 TRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPPP 727
            + A    ++   + P  P   P  ++ PS         P EP   ++ S+P     P P
Sbjct: 395 KKPAPTTPKEPAPTTPKEP--APTTTKEPSPTT------PKEPAPTTTKSAPTTTKEPAP 446

Query: 728 MSPSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSPPR 787
            +   +  +     P T   P     +          A      P     + P P +  +
Sbjct: 447 TTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 506

Query: 788 -APPPPPPPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSC--TSPRSPLPA 844
            AP  P  P P  P+  +P   +  +   P       P  P P  P     T+P  P P 
Sbjct: 507 PAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPT 566

Query: 845 PP 846
            P
Sbjct: 567 TP 568



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 171/866 (19%), Positives = 272/866 (31%), Gaps = 120/866 (13%)

Query: 5   SEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAEVHS 64
           S+E SL  + E     +E          +    T +        +      AP    +  
Sbjct: 178 SKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAK 237

Query: 65  PAADVNQNLASPSATLTT-PTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSEAQL 123
           P          P+ T    PT  +   P +T   +  P T+  +S P +   +  +    
Sbjct: 238 PTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTI--KSAPTTP--KEPAPTTT 293

Query: 124 PSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTS--TFSREATLIPSSR 181
            S  T P     T   +  P  P E    +T    K   P TT S  T  +E       +
Sbjct: 294 KSAPTTPKEPAPTTTKEPAPTTPKEPAPTTT----KEPAPTTTKSAPTTPKEPAPTTPKK 349

Query: 182 PPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTAR 241
           P  +     +     +P           +   A TTP +          KP     +   
Sbjct: 350 PAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAP---KKPAPTTPKEPA 406

Query: 242 PFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPP-SLPDRSPRPQRHIMSRSPMVERRMM 300
           P   + P  T+  E SP         K PAP    S P  +  P       +P   +   
Sbjct: 407 PTTPKEPAPTTTKEPSPTTP------KEPAPTTTKSAPTTTKEPAPTTTKSAPTTPK--- 457

Query: 301 GQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSD----PKSSHLKG 356
            + SP + + P       P  T     AP      +P +     P++     P +     
Sbjct: 458 -EPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPA 516

Query: 357 QAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGV 416
              P        + +      K   T  EKP  T   +L     T +E      +     
Sbjct: 517 PTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPT--TPEEPTPTTPE----- 569

Query: 417 EEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEA 476
           E  P    A A N  +EPAP     PA               P    +P P   +  +  
Sbjct: 570 EPAPTTPKAAAPNTPKEPAPTTPKEPA---------------PTTPKEPAPTTPKETAPT 614

Query: 477 SGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSP 536
           + KG      ++              P   + P+P    P++ K PT+           P
Sbjct: 615 TPKGTAPTTLKEP------------APTTPKKPAPKELAPTTTKEPTST------TCDKP 656

Query: 537 ARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSL 596
           A T P     G  P         T + P    P     + +KEPA  +P+     KP+  
Sbjct: 657 APTTPK----GTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPK-----KPAPK 707

Query: 597 DLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSP 656
           +L P   KG  P S    +P+ ++P            PT    P     +P +P +  +P
Sbjct: 708 ELAPTTTKG--PTSTTSDKPAPTTP--------KETAPTTPKEP-----APTTPKKP-AP 751

Query: 657 RAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGW---VSPGPWEPGRG 713
              + P P+ S  +     ++     PT+   +P  S P  S +     +   P EPG  
Sbjct: 752 TTPETPPPTTSEVSTPTTTKE-----PTTIHKSPDESTPELSAEPTPKALENSPKEPGVP 806

Query: 714 SSMSSPPPLPPPPPMSPSWSERSVS-PLR--PETEARPP--SRQLQALLARNIINAARRK 768
           ++ +   P    P M+ +  +++    LR  PET    P  +++      +   +     
Sbjct: 807 TTKT---PAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITAT 863

Query: 769 SASPRSAGAENPRPFSPPRAPPPPPPPPPPPPR--------MRSP-QPARPGSAAVPGAA 819
           +    S   ++  PF           P     +        M  P + A+P   A    A
Sbjct: 864 TTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKA 923

Query: 820 FAPIPRSPLPAGPSSCTSPRSPLPAP 845
             P P+ P  A P   TS + P   P
Sbjct: 924 TTPKPQKPTKA-PKKPTSTKKPKTMP 948



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 45/205 (21%), Positives = 65/205 (31%), Gaps = 13/205 (6%)

Query: 662 PRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGS--SMSSP 719
           P P   T   G      +E  PT+P   P ++ P       +   P  P   +  +  S 
Sbjct: 238 PTPKAETTTKGPALTTPKEPTPTTPK-EPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSA 296

Query: 720 PPLPPPPPMSPSWSERSVSPLRPE-TEARPPSRQLQALLARNIINAARRKSASPRSAGAE 778
           P  P  P  + +      +P  P  T  + P+              A      P     +
Sbjct: 297 PTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPK 356

Query: 779 NPRPFSPPRAPPPPPPPPPPPPRMRSPQPARPGSAA--VPGAAFAPIPRSPLPA-----G 831
            P P +P    P P  P  P P  + P P  P   A   P       P+ P P       
Sbjct: 357 EPAPTTPKE--PTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPA 414

Query: 832 PSSCTSPRSPLPAPPRPFLYRRSPT 856
           P++   P    P  P P   + +PT
Sbjct: 415 PTTTKEPSPTTPKEPAPTTTKSAPT 439



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 46/251 (18%), Positives = 86/251 (34%), Gaps = 17/251 (6%)

Query: 609 PSPALPRPSRSSPGL------YTSPGQDSLQPTAVSP-PYGGDISPVSPSRAWSPRAKQA 661
           P+P  P    +  GL       T+P   + Q   VS  P      P++P  +  P +  +
Sbjct: 119 PTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTS 178

Query: 662 PRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGW----VSPGPWEPGRGSSMS 717
              S  T N     + +  +       T G  +  S+ +       S     P     ++
Sbjct: 179 KETSL-TVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAP-TSKVLA 236

Query: 718 SPPPLPPPPPMSPSWSE-RSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAG 776
            P P        P+ +  +  +P  P+  A    ++      ++     +  + +   + 
Sbjct: 237 KPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSA 296

Query: 777 AENPRPFSPPRAPPPPPPPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCT 836
              P+  +P     P P  P  P    + +PA   + + P     P P +P    P   T
Sbjct: 297 PTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAP---T 353

Query: 837 SPRSPLPAPPR 847
           +P+ P P  P+
Sbjct: 354 TPKEPAPTTPK 364



 Score = 38.9 bits (89), Expect = 0.022
 Identities = 108/569 (18%), Positives = 183/569 (32%), Gaps = 116/569 (20%)

Query: 50  AQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSL 109
           A  ++  P P     PA    +  A  +    TPT+     P   +     PA   P+ L
Sbjct: 500 APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPE----KPAPTTPEEL 555

Query: 110 -PLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTS 168
            P +  +   +  + P+  T  A+ P+T      P+ PA             +TP     
Sbjct: 556 APTTPEEPTPTTPEEPAPTTPKAAAPNT------PKEPAP------------TTPKEPAP 597

Query: 169 TFSREA--TLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVH 226
           T  +E   T    + P      + + L +  P T    A +E++       PT       
Sbjct: 598 TTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELA-------PTTTKEPTS 650

Query: 227 FTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGE--KAPAPQPPSLPDRSPRP 284
            T  KP     +   P   + P  T+  E +P   +       K PAP  P    + P P
Sbjct: 651 TTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTP----KKPAP 706

Query: 285 QRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLY 344
           +        +      G  S  S++       AP T  ET  T P      +P   +   
Sbjct: 707 KE-------LAPTTTKGPTSTTSDK------PAPTTPKETAPTTPKEPAPTTPKKPAPTT 753

Query: 345 PSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADE 404
           P + P ++                             + V  P  T  P       T   
Sbjct: 754 PETPPPTT-----------------------------SEVSTPTTTKEP-------TTIH 777

Query: 405 KRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAK 464
           K       E+  E  P AL     N  +EP      +PAA +   PE  +  K    +  
Sbjct: 778 KSPDESTPELSAEPTPKAL----ENSPKEPGVPTTKTPAATK---PEMTTTAKDKTTERD 830

Query: 465 PKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTN 524
            +  P    +               +M K    ++  T E ++  + T  + S+    T 
Sbjct: 831 LRTTPETTTAAP-------------KMTKETATTTEKTTE-SKITATTTQVTSTTTQDTT 876

Query: 525 APGAFRVAS-RSPARTPPASLYHGYLPENGVL-RPEPTKQPPYQLRPSLFVLSPIKEPAK 582
               F++ + ++    P  +     +    ++ +PE T +P  +   S       ++P K
Sbjct: 877 P---FKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTK 933

Query: 583 VSPRAASPAKPSSLDLVPNLPKGALPPSP 611
              +  S  KP ++   P + K    P+P
Sbjct: 934 APKKPTSTKKPKTM---PRVRKPKTTPTP 959


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 87.0 bits (214), Expect = 7e-17
 Identities = 106/482 (21%), Positives = 183/482 (37%), Gaps = 60/482 (12%)

Query: 386 KPKVTPNPDLL-DLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAA 444
           +P + PN D   +   T +++     +      ++    G E +   +E    ++ S   
Sbjct: 220 RPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTS--- 276

Query: 445 AEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPE 504
           A+++ P       + ++ AKP PK     +E + KG  L   ++        E +S TP+
Sbjct: 277 AKDLAP-------TSKVLAKPTPK-----AETTTKGPALTTPKEPTPTTPK-EPASTTPK 323

Query: 505 LARCPSPTM--SLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQ 562
               P+PT   S P++ K P  AP   + A  +P    P +             P  TK+
Sbjct: 324 E---PTPTTIKSAPTTPKEP--APTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKE 378

Query: 563 PPYQLRPSLFVLSPI--KEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSS 620
           P     P+    +P   KEPA  +P+  +P  P   +  P  PK   P +P  P P+   
Sbjct: 379 PA----PTTTKSAPTTPKEPAPTTPKKPAPTTPK--EPAPTTPKEPTPTTPKEPAPTTKE 432

Query: 621 PGLYTSPGQDSLQPTAVSPPYGGDISPVSP-------SRAWSPRAKQAPRPSFSTRNAGI 673
           P   T        P   +P    + +P +P       ++  SP   + P P+ +T++A  
Sbjct: 433 PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPT-TTKSAPT 491

Query: 674 EAQDRRESLPTSPPWTPGASRPPSSLDGWVS----PGPWEPGRGSSMSSPPPLPPPPPMS 729
             ++   +   S P TP    P ++ +   +    P P  P + +  +   P P  P   
Sbjct: 492 TTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP 551

Query: 730 PSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSP---- 785
              + +  +P  P+  A    ++      + +      K A       E P P +P    
Sbjct: 552 APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTP---EKPAPTTPEELA 608

Query: 786 PRAPPPPPPPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAP 845
           P  P  P P  P  P   +P+ A P +   P       P+ P P      T+P+ P P  
Sbjct: 609 PTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPT---TPKEPAP------TTPKEPAPTT 659

Query: 846 PR 847
           P+
Sbjct: 660 PK 661



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 157/836 (18%), Positives = 270/836 (32%), Gaps = 116/836 (13%)

Query: 60  AEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSS 119
           AEVH+P +  +   A P +  +    +++   P     +     +  + +   + + + S
Sbjct: 64  AEVHNPTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEI---TEEHSVS 120

Query: 120 EAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPS 179
           E Q  S+ +  +S  ST+      +  A        L  K +    T           P+
Sbjct: 121 ENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKK--------PT 172

Query: 180 SRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTP-TKVYSEVHFTLAKPPSVVNR 238
            +PP  D   S L           + D +++    +TT   KV +    T AKP  +  R
Sbjct: 173 PKPPVVDEAGSGL----------DNGDFKVTTPDTSTTQHNKVSTSPKITTAKP--INPR 220

Query: 239 TARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERR 298
            + P     P   +  E S  + +    E               + +      +  +E+ 
Sbjct: 221 PSLP-----PNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEK- 274

Query: 299 MMGQRSPASERRPLGNFTAPPT-YTETLSTAPLASWVRSPPSYSVLYPSS----DPKSSH 353
                + A +  P     A PT   ET +  P  +  + P   +   P+S    +P  + 
Sbjct: 275 -----TSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTT 329

Query: 354 LKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGE 413
           +K       +        A    ++   T  ++P  T   +              +    
Sbjct: 330 IKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPT 389

Query: 414 VGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNL 473
              E  P      A    +EPAP     P       P  A   K P      +P P    
Sbjct: 390 TPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEP--APTTKEPAPTTPKEPAPTAPK 447

Query: 474 SEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVAS 533
             A     E              +  S T      P+ T S P++ K P  AP   + A 
Sbjct: 448 KPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEP--APTTTKSAP 505

Query: 534 RSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKP 593
            +P                    P PT                 KEPA  +P+  +P  P
Sbjct: 506 TTPKE------------------PSPTTT---------------KEPAPTTPKEPAPTTP 532

Query: 594 SSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDS-LQPTAVSPPYGGDISPVSPSR 652
                 P  PK   P +P  P P+ +     T+P + +   P   +P     ++P +P +
Sbjct: 533 KKP--APTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEK 590

Query: 653 AWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSP-PWTPGASRPPSSLDGWVSPGPWEPG 711
             +P   + P P+     A    ++   + P  P P TP A+ P +  +    P P  P 
Sbjct: 591 L-APTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE----PAPTTPK 645

Query: 712 RGSSMSSPPPLPPPPPMSPSWSERSVSPLR-----PETEARPPSRQLQALLARNIINAAR 766
             +  +   P P  P  +   + +  +P       P T  +P  ++L     +   +   
Sbjct: 646 EPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTC 705

Query: 767 RKSA--SPRSAGAENPRPFSP--PRAPPPPPP---------------PPPPPPRMRSPQP 807
            K A  +P+      P+  +P  P+ P P  P               P  P P+  +P  
Sbjct: 706 DKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTT 765

Query: 808 ARPGSAAVPGAAFAPIPRSPLPAGPS--SCTSPRSPLPAPPRPFLYRRSPTDSDVS 861
            +  ++          P+   P  P   + T+P+ P P  P        PT S+VS
Sbjct: 766 TKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPE----TPPPTTSEVS 817



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 159/772 (20%), Positives = 246/772 (31%), Gaps = 77/772 (9%)

Query: 46  QNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTP-TSNSSHNPPATDVNQNPPATV 104
           +NR  ++ +P PP  +      +    L +    +TTP TS + HN  +T         +
Sbjct: 164 KNRTKKKPTPKPPVVD------EAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPI 217

Query: 105 VPQ-SLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTP 163
            P+ SLP +S    S E  L  N         T   + Q     +E   +T   +  S  
Sbjct: 218 NPRPSLPPNS--DTSKETSLTVNKETTVETKETTTTNKQTSTDGKEK--TTSAKETQSIE 273

Query: 164 ATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYS 223
            T+    +  + ++    P A        L   +  T   +  +  S      TPT + S
Sbjct: 274 KTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPT-PTTPKEPASTTPKEPTPTTIKS 332

Query: 224 EVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPR 283
               T  K P+     + P   + P  T+  E +P         K PAP     P  +  
Sbjct: 333 AP--TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTT------PKEPAPTTTKEPAPTTT 384

Query: 284 PQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVL 343
                  + P          +P + ++P     AP T  E   T P      +P   +  
Sbjct: 385 KSAPTTPKEP----------APTTPKKP-----APTTPKEPAPTTPKEPTPTTPKEPAPT 429

Query: 344 YPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVT----PNPDLLDLV 399
                P +        P        +  A    ++   T  ++P  T    P P      
Sbjct: 430 TKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSA 489

Query: 400 QTADEK---RRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCL 456
            T  ++      +       E  P      A    +EPAP     PA      P   +  
Sbjct: 490 PTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA-PTTP 548

Query: 457 KSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIES-SSHTPELARCPSPTMSL 515
           K P      KP P      A     E       ++     E  +  TPE     +P    
Sbjct: 549 KEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELA 608

Query: 516 PSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLS 575
           P++ + PT            PA T P +        N    P PT   P +  P+    +
Sbjct: 609 PTTPEEPT------PTTPEEPAPTTPKA-----AAPNTPKEPAPT--TPKEPAPT----T 651

Query: 576 PIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPT 635
           P KEPA  +P+  +P  P      P   K   P +P  P P   +P     P   +    
Sbjct: 652 P-KEPAPTTPKETAPTTPKG--TAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP 708

Query: 636 AVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRP 695
           A + P G   +P +P    +P   + P P   T   G      +E  PT+P         
Sbjct: 709 APTTPKG--TAPTTPKEP-APTTPKEPAP---TTPKGTAPTTLKEPAPTTPKKPAPKELA 762

Query: 696 PSSLDGWVSPGPWEPGRGSSMSSPPPLP-PPPPMSPSWSERSVSPLRPETEARPPSRQLQ 754
           P++  G  S    +P   +   + P  P  P P +P    +  +P  PET     S    
Sbjct: 763 PTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTP----KKPAPTTPETPPPTTSEVST 818

Query: 755 ALLARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQ 806
               +      +    S     AE P P +   +P  P  P    P    P+
Sbjct: 819 PTTTKEPTTIHKSPDESTPELSAE-PTPKALENSPKEPGVPTTKTPAATKPE 869



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 171/866 (19%), Positives = 272/866 (31%), Gaps = 120/866 (13%)

Query: 5    SEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAEVHS 64
            S+E SL  + E     +E          +    T +        +      AP    +  
Sbjct: 230  SKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAK 289

Query: 65   PAADVNQNLASPSATLTT-PTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSEAQL 123
            P          P+ T    PT  +   P +T   +  P T+  +S P +   +  +    
Sbjct: 290  PTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTI--KSAPTTP--KEPAPTTT 345

Query: 124  PSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTS--TFSREATLIPSSR 181
             S  T P     T   +  P  P E    +T    K   P TT S  T  +E       +
Sbjct: 346  KSAPTTPKEPAPTTTKEPAPTTPKEPAPTTT----KEPAPTTTKSAPTTPKEPAPTTPKK 401

Query: 182  PPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTAR 241
            P  +     +     +P           +   A TTP +          KP     +   
Sbjct: 402  PAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAP---KKPAPTTPKEPA 458

Query: 242  PFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPP-SLPDRSPRPQRHIMSRSPMVERRMM 300
            P   + P  T+  E SP         K PAP    S P  +  P       +P   +   
Sbjct: 459  PTTPKEPAPTTTKEPSPTTP------KEPAPTTTKSAPTTTKEPAPTTTKSAPTTPK--- 509

Query: 301  GQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSD----PKSSHLKG 356
             + SP + + P       P  T     AP      +P +     P++     P +     
Sbjct: 510  -EPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPA 568

Query: 357  QAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGV 416
               P        + +      K   T  EKP  T   +L     T +E      +     
Sbjct: 569  PTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPT--TPEEPTPTTPE----- 621

Query: 417  EEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEA 476
            E  P    A A N  +EPAP     PA               P    +P P   +  +  
Sbjct: 622  EPAPTTPKAAAPNTPKEPAPTTPKEPA---------------PTTPKEPAPTTPKETAPT 666

Query: 477  SGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSP 536
            + KG      ++              P   + P+P    P++ K PT+           P
Sbjct: 667  TPKGTAPTTLKEP------------APTTPKKPAPKELAPTTTKEPTST------TCDKP 708

Query: 537  ARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSL 596
            A T P     G  P         T + P    P     + +KEPA  +P+     KP+  
Sbjct: 709  APTTPK----GTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPK-----KPAPK 759

Query: 597  DLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSP 656
            +L P   KG  P S    +P+ ++P            PT    P     +P +P +  +P
Sbjct: 760  ELAPTTTKG--PTSTTSDKPAPTTP--------KETAPTTPKEP-----APTTPKKP-AP 803

Query: 657  RAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGW---VSPGPWEPGRG 713
               + P P+ S  +     ++     PT+   +P  S P  S +     +   P EPG  
Sbjct: 804  TTPETPPPTTSEVSTPTTTKE-----PTTIHKSPDESTPELSAEPTPKALENSPKEPGVP 858

Query: 714  SSMSSPPPLPPPPPMSPSWSERSVS-PLR--PETEARPP--SRQLQALLARNIINAARRK 768
            ++ +   P    P M+ +  +++    LR  PET    P  +++      +   +     
Sbjct: 859  TTKT---PAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITAT 915

Query: 769  SASPRSAGAENPRPFSPPRAPPPPPPPPPPPPR--------MRSP-QPARPGSAAVPGAA 819
            +    S   ++  PF           P     +        M  P + A+P   A    A
Sbjct: 916  TTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKA 975

Query: 820  FAPIPRSPLPAGPSSCTSPRSPLPAP 845
              P P+ P  A P   TS + P   P
Sbjct: 976  TTPKPQKPTKA-PKKPTSTKKPKTMP 1000



 Score = 38.9 bits (89), Expect = 0.022
 Identities = 108/569 (18%), Positives = 183/569 (32%), Gaps = 116/569 (20%)

Query: 50   AQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSL 109
            A  ++  P P     PA    +  A  +    TPT+     P   +     PA   P+ L
Sbjct: 552  APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPE----KPAPTTPEEL 607

Query: 110  -PLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTS 168
             P +  +   +  + P+  T  A+ P+T      P+ PA             +TP     
Sbjct: 608  APTTPEEPTPTTPEEPAPTTPKAAAPNT------PKEPAP------------TTPKEPAP 649

Query: 169  TFSREA--TLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVH 226
            T  +E   T    + P      + + L +  P T    A +E++       PT       
Sbjct: 650  TTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELA-------PTTTKEPTS 702

Query: 227  FTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGE--KAPAPQPPSLPDRSPRP 284
             T  KP     +   P   + P  T+  E +P   +       K PAP  P    + P P
Sbjct: 703  TTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTP----KKPAP 758

Query: 285  QRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLY 344
            +        +      G  S  S++       AP T  ET  T P      +P   +   
Sbjct: 759  KE-------LAPTTTKGPTSTTSDK------PAPTTPKETAPTTPKEPAPTTPKKPAPTT 805

Query: 345  PSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADE 404
            P + P ++                             + V  P  T  P       T   
Sbjct: 806  PETPPPTT-----------------------------SEVSTPTTTKEP-------TTIH 829

Query: 405  KRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAK 464
            K       E+  E  P AL     N  +EP      +PAA +   PE  +  K    +  
Sbjct: 830  KSPDESTPELSAEPTPKAL----ENSPKEPGVPTTKTPAATK---PEMTTTAKDKTTERD 882

Query: 465  PKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTN 524
             +  P    +               +M K    ++  T E ++  + T  + S+    T 
Sbjct: 883  LRTTPETTTAAP-------------KMTKETATTTEKTTE-SKITATTTQVTSTTTQDTT 928

Query: 525  APGAFRVAS-RSPARTPPASLYHGYLPENGVL-RPEPTKQPPYQLRPSLFVLSPIKEPAK 582
                F++ + ++    P  +     +    ++ +PE T +P  +   S       ++P K
Sbjct: 929  P---FKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTK 985

Query: 583  VSPRAASPAKPSSLDLVPNLPKGALPPSP 611
               +  S  KP ++   P + K    P+P
Sbjct: 986  APKKPTSTKKPKTM---PRVRKPKTTPTP 1011


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 87.0 bits (214), Expect = 7e-17
 Identities = 106/482 (21%), Positives = 183/482 (37%), Gaps = 60/482 (12%)

Query: 386 KPKVTPNPDLL-DLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAA 444
           +P + PN D   +   T +++     +      ++    G E +   +E    ++ S   
Sbjct: 261 RPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTS--- 317

Query: 445 AEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPE 504
           A+++ P       + ++ AKP PK     +E + KG  L   ++        E +S TP+
Sbjct: 318 AKDLAP-------TSKVLAKPTPK-----AETTTKGPALTTPKEPTPTTPK-EPASTTPK 364

Query: 505 LARCPSPTM--SLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQ 562
               P+PT   S P++ K P  AP   + A  +P    P +             P  TK+
Sbjct: 365 E---PTPTTIKSAPTTPKEP--APTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKE 419

Query: 563 PPYQLRPSLFVLSPI--KEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSS 620
           P     P+    +P   KEPA  +P+  +P  P   +  P  PK   P +P  P P+   
Sbjct: 420 PA----PTTTKSAPTTPKEPAPTTPKKPAPTTPK--EPAPTTPKEPTPTTPKEPAPTTKE 473

Query: 621 PGLYTSPGQDSLQPTAVSPPYGGDISPVSP-------SRAWSPRAKQAPRPSFSTRNAGI 673
           P   T        P   +P    + +P +P       ++  SP   + P P+ +T++A  
Sbjct: 474 PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPT-TTKSAPT 532

Query: 674 EAQDRRESLPTSPPWTPGASRPPSSLDGWVS----PGPWEPGRGSSMSSPPPLPPPPPMS 729
             ++   +   S P TP    P ++ +   +    P P  P + +  +   P P  P   
Sbjct: 533 TTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP 592

Query: 730 PSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSP---- 785
              + +  +P  P+  A    ++      + +      K A       E P P +P    
Sbjct: 593 APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTP---EKPAPTTPEELA 649

Query: 786 PRAPPPPPPPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAP 845
           P  P  P P  P  P   +P+ A P +   P       P+ P P      T+P+ P P  
Sbjct: 650 PTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPT---TPKEPAP------TTPKEPAPTT 700

Query: 846 PR 847
           P+
Sbjct: 701 PK 702



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 157/836 (18%), Positives = 270/836 (32%), Gaps = 116/836 (13%)

Query: 60  AEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSS 119
           AEVH+P +  +   A P +  +    +++   P     +     +  + +   + + + S
Sbjct: 105 AEVHNPTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEI---TEEHSVS 161

Query: 120 EAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPS 179
           E Q  S+ +  +S  ST+      +  A        L  K +    T           P+
Sbjct: 162 ENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKK--------PT 213

Query: 180 SRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTP-TKVYSEVHFTLAKPPSVVNR 238
            +PP  D   S L           + D +++    +TT   KV +    T AKP  +  R
Sbjct: 214 PKPPVVDEAGSGL----------DNGDFKVTTPDTSTTQHNKVSTSPKITTAKP--INPR 261

Query: 239 TARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERR 298
            + P     P   +  E S  + +    E               + +      +  +E+ 
Sbjct: 262 PSLP-----PNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEK- 315

Query: 299 MMGQRSPASERRPLGNFTAPPT-YTETLSTAPLASWVRSPPSYSVLYPSS----DPKSSH 353
                + A +  P     A PT   ET +  P  +  + P   +   P+S    +P  + 
Sbjct: 316 -----TSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTT 370

Query: 354 LKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGE 413
           +K       +        A    ++   T  ++P  T   +              +    
Sbjct: 371 IKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPT 430

Query: 414 VGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNL 473
              E  P      A    +EPAP     P       P  A   K P      +P P    
Sbjct: 431 TPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEP--APTTKEPAPTTPKEPAPTAPK 488

Query: 474 SEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVAS 533
             A     E              +  S T      P+ T S P++ K P  AP   + A 
Sbjct: 489 KPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEP--APTTTKSAP 546

Query: 534 RSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKP 593
            +P                    P PT                 KEPA  +P+  +P  P
Sbjct: 547 TTPKE------------------PSPTTT---------------KEPAPTTPKEPAPTTP 573

Query: 594 SSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDS-LQPTAVSPPYGGDISPVSPSR 652
                 P  PK   P +P  P P+ +     T+P + +   P   +P     ++P +P +
Sbjct: 574 KKP--APTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEK 631

Query: 653 AWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSP-PWTPGASRPPSSLDGWVSPGPWEPG 711
             +P   + P P+     A    ++   + P  P P TP A+ P +  +    P P  P 
Sbjct: 632 L-APTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE----PAPTTPK 686

Query: 712 RGSSMSSPPPLPPPPPMSPSWSERSVSPLR-----PETEARPPSRQLQALLARNIINAAR 766
             +  +   P P  P  +   + +  +P       P T  +P  ++L     +   +   
Sbjct: 687 EPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTC 746

Query: 767 RKSA--SPRSAGAENPRPFSP--PRAPPPPPP---------------PPPPPPRMRSPQP 807
            K A  +P+      P+  +P  P+ P P  P               P  P P+  +P  
Sbjct: 747 DKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTT 806

Query: 808 ARPGSAAVPGAAFAPIPRSPLPAGPS--SCTSPRSPLPAPPRPFLYRRSPTDSDVS 861
            +  ++          P+   P  P   + T+P+ P P  P        PT S+VS
Sbjct: 807 TKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPE----TPPPTTSEVS 858



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 159/772 (20%), Positives = 246/772 (31%), Gaps = 77/772 (9%)

Query: 46  QNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTP-TSNSSHNPPATDVNQNPPATV 104
           +NR  ++ +P PP  +      +    L +    +TTP TS + HN  +T         +
Sbjct: 205 KNRTKKKPTPKPPVVD------EAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPI 258

Query: 105 VPQ-SLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTP 163
            P+ SLP +S    S E  L  N         T   + Q     +E   +T   +  S  
Sbjct: 259 NPRPSLPPNS--DTSKETSLTVNKETTVETKETTTTNKQTSTDGKEK--TTSAKETQSIE 314

Query: 164 ATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYS 223
            T+    +  + ++    P A        L   +  T   +  +  S      TPT + S
Sbjct: 315 KTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPT-PTTPKEPASTTPKEPTPTTIKS 373

Query: 224 EVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPR 283
               T  K P+     + P   + P  T+  E +P         K PAP     P  +  
Sbjct: 374 AP--TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTT------PKEPAPTTTKEPAPTTT 425

Query: 284 PQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVL 343
                  + P          +P + ++P     AP T  E   T P      +P   +  
Sbjct: 426 KSAPTTPKEP----------APTTPKKP-----APTTPKEPAPTTPKEPTPTTPKEPAPT 470

Query: 344 YPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVT----PNPDLLDLV 399
                P +        P        +  A    ++   T  ++P  T    P P      
Sbjct: 471 TKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSA 530

Query: 400 QTADEK---RRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCL 456
            T  ++      +       E  P      A    +EPAP     PA      P   +  
Sbjct: 531 PTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA-PTTP 589

Query: 457 KSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIES-SSHTPELARCPSPTMSL 515
           K P      KP P      A     E       ++     E  +  TPE     +P    
Sbjct: 590 KEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELA 649

Query: 516 PSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLS 575
           P++ + PT            PA T P +        N    P PT   P +  P+    +
Sbjct: 650 PTTPEEPT------PTTPEEPAPTTPKA-----AAPNTPKEPAPT--TPKEPAPT----T 692

Query: 576 PIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPT 635
           P KEPA  +P+  +P  P      P   K   P +P  P P   +P     P   +    
Sbjct: 693 P-KEPAPTTPKETAPTTPKG--TAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP 749

Query: 636 AVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRP 695
           A + P G   +P +P    +P   + P P   T   G      +E  PT+P         
Sbjct: 750 APTTPKG--TAPTTPKEP-APTTPKEPAP---TTPKGTAPTTLKEPAPTTPKKPAPKELA 803

Query: 696 PSSLDGWVSPGPWEPGRGSSMSSPPPLP-PPPPMSPSWSERSVSPLRPETEARPPSRQLQ 754
           P++  G  S    +P   +   + P  P  P P +P    +  +P  PET     S    
Sbjct: 804 PTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTP----KKPAPTTPETPPPTTSEVST 859

Query: 755 ALLARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQ 806
               +      +    S     AE P P +   +P  P  P    P    P+
Sbjct: 860 PTTTKEPTTIHKSPDESTPELSAE-PTPKALENSPKEPGVPTTKTPAATKPE 910



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 171/866 (19%), Positives = 272/866 (31%), Gaps = 120/866 (13%)

Query: 5    SEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAEVHS 64
            S+E SL  + E     +E          +    T +        +      AP    +  
Sbjct: 271  SKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAK 330

Query: 65   PAADVNQNLASPSATLTT-PTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSEAQL 123
            P          P+ T    PT  +   P +T   +  P T+  +S P +   +  +    
Sbjct: 331  PTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTI--KSAPTTP--KEPAPTTT 386

Query: 124  PSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTS--TFSREATLIPSSR 181
             S  T P     T   +  P  P E    +T    K   P TT S  T  +E       +
Sbjct: 387  KSAPTTPKEPAPTTTKEPAPTTPKEPAPTTT----KEPAPTTTKSAPTTPKEPAPTTPKK 442

Query: 182  PPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTAR 241
            P  +     +     +P           +   A TTP +          KP     +   
Sbjct: 443  PAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAP---KKPAPTTPKEPA 499

Query: 242  PFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPP-SLPDRSPRPQRHIMSRSPMVERRMM 300
            P   + P  T+  E SP         K PAP    S P  +  P       +P   +   
Sbjct: 500  PTTPKEPAPTTTKEPSPTTP------KEPAPTTTKSAPTTTKEPAPTTTKSAPTTPK--- 550

Query: 301  GQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSD----PKSSHLKG 356
             + SP + + P       P  T     AP      +P +     P++     P +     
Sbjct: 551  -EPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPA 609

Query: 357  QAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGV 416
               P        + +      K   T  EKP  T   +L     T +E      +     
Sbjct: 610  PTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPT--TPEEPTPTTPE----- 662

Query: 417  EEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEA 476
            E  P    A A N  +EPAP     PA               P    +P P   +  +  
Sbjct: 663  EPAPTTPKAAAPNTPKEPAPTTPKEPA---------------PTTPKEPAPTTPKETAPT 707

Query: 477  SGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSP 536
            + KG      ++              P   + P+P    P++ K PT+           P
Sbjct: 708  TPKGTAPTTLKEP------------APTTPKKPAPKELAPTTTKEPTST------TCDKP 749

Query: 537  ARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSL 596
            A T P     G  P         T + P    P     + +KEPA  +P+     KP+  
Sbjct: 750  APTTPK----GTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPK-----KPAPK 800

Query: 597  DLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSP 656
            +L P   KG  P S    +P+ ++P            PT    P     +P +P +  +P
Sbjct: 801  ELAPTTTKG--PTSTTSDKPAPTTP--------KETAPTTPKEP-----APTTPKKP-AP 844

Query: 657  RAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGW---VSPGPWEPGRG 713
               + P P+ S  +     ++     PT+   +P  S P  S +     +   P EPG  
Sbjct: 845  TTPETPPPTTSEVSTPTTTKE-----PTTIHKSPDESTPELSAEPTPKALENSPKEPGVP 899

Query: 714  SSMSSPPPLPPPPPMSPSWSERSVS-PLR--PETEARPP--SRQLQALLARNIINAARRK 768
            ++ +   P    P M+ +  +++    LR  PET    P  +++      +   +     
Sbjct: 900  TTKT---PAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITAT 956

Query: 769  SASPRSAGAENPRPFSPPRAPPPPPPPPPPPPR--------MRSP-QPARPGSAAVPGAA 819
            +    S   ++  PF           P     +        M  P + A+P   A    A
Sbjct: 957  TTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKA 1016

Query: 820  FAPIPRSPLPAGPSSCTSPRSPLPAP 845
              P P+ P  A P   TS + P   P
Sbjct: 1017 TTPKPQKPTKA-PKKPTSTKKPKTMP 1041



 Score = 38.9 bits (89), Expect = 0.022
 Identities = 108/569 (18%), Positives = 183/569 (32%), Gaps = 116/569 (20%)

Query: 50   AQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSL 109
            A  ++  P P     PA    +  A  +    TPT+     P   +     PA   P+ L
Sbjct: 593  APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPE----KPAPTTPEEL 648

Query: 110  -PLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTS 168
             P +  +   +  + P+  T  A+ P+T      P+ PA             +TP     
Sbjct: 649  APTTPEEPTPTTPEEPAPTTPKAAAPNT------PKEPAP------------TTPKEPAP 690

Query: 169  TFSREA--TLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVH 226
            T  +E   T    + P      + + L +  P T    A +E++       PT       
Sbjct: 691  TTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELA-------PTTTKEPTS 743

Query: 227  FTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGE--KAPAPQPPSLPDRSPRP 284
             T  KP     +   P   + P  T+  E +P   +       K PAP  P    + P P
Sbjct: 744  TTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTP----KKPAP 799

Query: 285  QRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLY 344
            +        +      G  S  S++       AP T  ET  T P      +P   +   
Sbjct: 800  KE-------LAPTTTKGPTSTTSDK------PAPTTPKETAPTTPKEPAPTTPKKPAPTT 846

Query: 345  PSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADE 404
            P + P ++                             + V  P  T  P       T   
Sbjct: 847  PETPPPTT-----------------------------SEVSTPTTTKEP-------TTIH 870

Query: 405  KRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAK 464
            K       E+  E  P AL     N  +EP      +PAA +   PE  +  K    +  
Sbjct: 871  KSPDESTPELSAEPTPKAL----ENSPKEPGVPTTKTPAATK---PEMTTTAKDKTTERD 923

Query: 465  PKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTN 524
             +  P    +               +M K    ++  T E ++  + T  + S+    T 
Sbjct: 924  LRTTPETTTAAP-------------KMTKETATTTEKTTE-SKITATTTQVTSTTTQDTT 969

Query: 525  APGAFRVAS-RSPARTPPASLYHGYLPENGVL-RPEPTKQPPYQLRPSLFVLSPIKEPAK 582
                F++ + ++    P  +     +    ++ +PE T +P  +   S       ++P K
Sbjct: 970  P---FKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTK 1026

Query: 583  VSPRAASPAKPSSLDLVPNLPKGALPPSP 611
               +  S  KP ++   P + K    P+P
Sbjct: 1027 APKKPTSTKKPKTM---PRVRKPKTTPTP 1052


>gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Homo
           sapiens]
          Length = 1188

 Score = 83.6 bits (205), Expect = 8e-16
 Identities = 95/337 (28%), Positives = 131/337 (38%), Gaps = 40/337 (11%)

Query: 522 PTNAPGAFRVASRSPARTP-PASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEP 580
           P  APG  +  S  P  +P P+       P   +L P P   PP    P   VL  +  P
Sbjct: 144 PGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPP---PPSMAPPPPPVLEALSPP 200

Query: 581 AKVSPRAASPAKPSSLDLVPNLPKGAL--PPSPALPRPSRSSPGLYTSPGQDSLQPTAVS 638
             +S    SP+ P+  D +P  P  A   PP P +P P+  +P    + G     P  V+
Sbjct: 201 HTLS----SPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVT 256

Query: 639 PPYGGDIS----PVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTS---PPWTPG 691
             +  D++        +RA  PR+   P+ S    N      +   + P S   PP TP 
Sbjct: 257 K-WKSDVALNGRQAEATRASPPRSPAEPKGSALGPNP-----EPHLTFPRSFKVPPPTPV 310

Query: 692 ASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPPPMSPSWSERSVSPLRPETEARPPSR 751
            +      +   +P   E   G++  +P  LP PP    S+  R  S + P+    P   
Sbjct: 311 RTSSIPVQEAQEAPRKEE---GATKKAPSRLPLPP----SFHIRPASQVYPDRAPEPDCP 363

Query: 752 QLQALLARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQPARPG 811
                 A       + +S +   AG   P P  PP APP PPP PP PP   +P      
Sbjct: 364 GELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPP--AAPPLPCAQ 421

Query: 812 SAAVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAPPRP 848
            AA P A F   P+S  PA          P P PP P
Sbjct: 422 KAAHPPAGFTKTPKSSSPA--------LKPKPNPPSP 450



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 187/817 (22%), Positives = 268/817 (32%), Gaps = 177/817 (21%)

Query: 55  PAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSI 114
           P PPP     P  D+++      + L +P S +   PP   +   PP ++ P   P+   
Sbjct: 140 PPPPPGPAPGPPQDISE--PPGGSPLPSPPSTAPPPPPLL-LEPPPPPSMAPPPPPVLEA 196

Query: 115 QQNSSEAQLPSNGTGP----ASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTF 170
                    PS  T P     + P    A   P  PA               P    S  
Sbjct: 197 LSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAP-------------APPAPASPH 243

Query: 171 SREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQ---EMSGRAAATTPTKVYSEVHF 227
           +    L P      + + S   L   Q      S  +   E  G A    P     E H 
Sbjct: 244 TVGTRLFPPGG--VTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNP-----EPHL 296

Query: 228 TLAK-----PPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPA--PQPPSL--- 277
           T  +     PP+ V  ++ P          + + +P  E     +KAP+  P PPS    
Sbjct: 297 TFPRSFKVPPPTPVRTSSIP--------VQEAQEAPRKEEGAT-KKAPSRLPLPPSFHIR 347

Query: 278 ------PDRSPRPQ--RHIMSRSPMVERRMMGQ-RSPASERR------------------ 310
                 PDR+P P     + + +P   R  +GQ +S A ER                   
Sbjct: 348 PASQVYPDRAPEPDCPGELKATAPASPR--LGQSQSQADERAGTPPPAPPLPPPAPPLPP 405

Query: 311 ---PLGNFTAPPTYTETLSTAPLASWVRSPPSYS-VLYPSSDPKSSHLKGQAVPA----- 361
              PL    APP      +  P A + ++P S S  L P  +P S      + P      
Sbjct: 406 PAPPLPP-AAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDP 464

Query: 362 SKTGILEESMARR--GSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEE 419
           S+   L   +A    GSR+       +P  T  P      Q+ + K+  R      + E+
Sbjct: 465 SQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAP------QSKEGKKGPR------LPEK 512

Query: 420 PFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGK 479
              L   A +    P      S   +     E A  L  P +   P+  P  ++ +    
Sbjct: 513 ETLLSLPAKD---TPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRN- 568

Query: 480 GAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPART 539
             EL AR  S  EK    S    P     P P +      +   N     +++       
Sbjct: 569 --ELEARLSSAAEKEAKPSIGSLP-----PKPRLE---GGRICENGADDDKLSKPVAKNL 618

Query: 540 PPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLV 599
           PP S           L P  + QP   L P++        P K +P  A P K +     
Sbjct: 619 PPQST---------TLLPTTSLQPKAMLGPAI--------PPKATPEPAIPPKATLWPAT 661

Query: 600 PNLPKGALPPS--------PALPRPSRSSPGLY----TSPGQDS-LQPTAVSPPYGGDIS 646
           P  PK  L P+        P  P  + S P +     T P   S L     S P G    
Sbjct: 662 P--PKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEK 719

Query: 647 PVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPP---------S 697
           P S   +   +A+    PS +TR   +  Q  R S    P  +PG    P         S
Sbjct: 720 PASQEVSTPSQARGEGSPSEATR---LPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQS 776

Query: 698 SLDGWVSP--------GPWEPGRGSSMSSPPPLPPPPPMSPSWSERSV-SPLRPETEARP 748
           SL   V+         G   PG    +  PP LP  PP S   ++  +  P+  E   R 
Sbjct: 777 SLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERG 836

Query: 749 PSRQLQALLARNIINAARRKSASPRSAGAENPRPFSP 785
               L        + AAR+++   RS GA   R   P
Sbjct: 837 SPMAL--------LLAARQRAQKGRSVGAALGRSSLP 865



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 154/658 (23%), Positives = 211/658 (32%), Gaps = 132/658 (20%)

Query: 265 FGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTET 324
           +G+    P PP  P  +P P + I                P     P    TAPP     
Sbjct: 133 YGQDLLIPPPP--PGPAPGPPQDI-------------SEPPGGSPLPSPPSTAPPPPPLL 177

Query: 325 LSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFV 384
           L   P  S    PP   VL   S P +  L   ++P     I             +    
Sbjct: 178 LEPPPPPSMAPPPPP--VLEALSPPHT--LSSPSIPTPPDFI--------PPAPPLAFLA 225

Query: 385 EKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAA 444
             P   P P             R    G V   +   AL    +   +   PR  A P  
Sbjct: 226 PPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKG 285

Query: 445 AEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPE 504
           +  + P     L  PR    P P P +  S    +  E   + +   +K         P 
Sbjct: 286 SA-LGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKK--------APS 336

Query: 505 LARCPSPTMSLPSSWKYPTNAPGAF---RVASRSPARTPPASLYHGYLPEN-GVLRPEPT 560
               P      P+S  YP  AP       + + +PA +P          E  G   P P 
Sbjct: 337 RLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPA-SPRLGQSQSQADERAGTPPPAPP 395

Query: 561 KQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSS 620
             PP           P+  PA   P AA P        +P   K A PP+     P  SS
Sbjct: 396 LPPP---------APPLPPPAPPLPPAAPP--------LPCAQKAAHPPAGFTKTPKSSS 438

Query: 621 PGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAW-SPRAKQAPRPSFSTRNAGIEAQDRR 679
           P L   P   S + TA S P             W  P   +  R   +    G   +DR 
Sbjct: 439 PALKPKPNPPSPENTASSAPVD-----------WRDPSQMEKLRNELAAYLCGSRREDRF 487

Query: 680 ESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMS-----SPPPLPPPPPMSPSWSE 734
            S        PG +  P S +G    GP  P + + +S     +PP +P       S +E
Sbjct: 488 LS------HRPGPTVAPQSKEG--KKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTE 539

Query: 735 RSVSP--------LRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAENPRP---- 782
              +P          P+    P  RQ++  L   + +AA  K A P S G+  P+P    
Sbjct: 540 TEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAA-EKEAKP-SIGSLPPKPRLEG 597

Query: 783 ------------FSPPRAPPPPPPPP---------------PPPPRMRSPQPARPGSAAV 815
                        S P A   PP                  P  P   +P+PA P  A +
Sbjct: 598 GRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATL 657

Query: 816 PGAAFAPIPRSPL-PAGPSSCTS-PRSPLPAPPRPFLYRRS---PTDSDVSLDSEDSG 868
             A     P++ L PA P   TS P +PL A   P +   +   PT +   +  +DSG
Sbjct: 658 WPAT---PPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSG 712



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 62/223 (27%), Positives = 74/223 (33%), Gaps = 57/223 (25%)

Query: 686 PPWTPG-ASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPPPMSPSWSERSVSPLRPET 744
           PP  PG A  PP  +       P      ++   PP L  PPP              P +
Sbjct: 140 PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPP--------------PPS 185

Query: 745 EARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSPPR------APPPPPPPPPP 798
            A PP   L+AL   + ++          S     P  F PP       APPPPP P P 
Sbjct: 186 MAPPPPPVLEALSPPHTLS----------SPSIPTPPDFIPPAPPLAFLAPPPPPVPAPA 235

Query: 799 PPRMRSPQPA-----RPG-------SAAVPG----AAFAPIPRSPL--------PAGPSS 834
           PP   SP         PG         A+ G    A  A  PRSP         P     
Sbjct: 236 PPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPH 295

Query: 835 CTSPRSPLPAPPRPFLYRRSPTDSDVSLDSEDSGA--KSPGIL 875
            T PRS    PP P      P         ++ GA  K+P  L
Sbjct: 296 LTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRL 338



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 51/182 (28%), Positives = 59/182 (32%), Gaps = 50/182 (27%)

Query: 704 SPGPWEPGR-GSSMSSPPPLPPPPPMSPSWSER----SVSPLRPETEARPPSRQLQALLA 758
           S G   PG+ G  +  PPP P P P  P         S  P  P T   PP   L+    
Sbjct: 124 SVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLE---- 179

Query: 759 RNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPP---PPPPPPRMRSPQPARPGS--A 813
                                  P  PP   PPPPP      PP  + SP    P     
Sbjct: 180 -----------------------PPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIP 216

Query: 814 AVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAPPRPFLYRRSPT------DSDVSLDSEDS 867
             P  AF   P  P+PA       P  P PA P     R  P        SDV+L+   +
Sbjct: 217 PAPPLAFLAPPPPPVPA-------PAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQA 269

Query: 868 GA 869
            A
Sbjct: 270 EA 271



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 148/675 (21%), Positives = 235/675 (34%), Gaps = 103/675 (15%)

Query: 55   PAPPPAEVHSPAAD---VNQNLASPSATLT-TPTSNS-----SHNPPATD-------VNQ 98
            P PPPA    PAA      Q  A P A  T TP S+S       NPP+ +       V+ 
Sbjct: 402  PLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDW 461

Query: 99   NPPATVVPQSLPLSSIQQNSS-EAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLI 157
              P+ +      L++    S  E +  S+  GP   P +      P+ P +E    TLL 
Sbjct: 462  RDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKE----TLL- 516

Query: 158  DKVSTPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATT 217
               S PA  T          P   P  S   SS    +  P+  + S D          +
Sbjct: 517  ---SLPAKDT----------PPGVPEKSLGGSSLTETEAAPSLTLPSVDY-----IPQDS 558

Query: 218  PTKVYSEVHFTL-AKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPS 276
            PT    ++   L A+  S   + A+P  I +     ++E   + E     +K   P   +
Sbjct: 559  PTPSVRQIRNELEARLSSAAEKEAKP-SIGSLPPKPRLEGGRICENGADDDKLSKPVAKN 617

Query: 277  LPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRS 336
            LP +S      ++  + +  + M+G   PA   +       PP  T   +T P A+   +
Sbjct: 618  LPPQSTT----LLPTTSLQPKAMLG---PAIPPKATPEPAIPPKATLWPATPPKATLGPA 670

Query: 337  PPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLL 396
             P  +   P++  K++   G A+ ++ T +   +      + S       P   P     
Sbjct: 671  TPLKATSGPTTPLKAT--SGPAIASTATTLPTTTSQLMAEKDS------GPAGQPEKPAS 722

Query: 397  DLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCL 456
              V T  + R +    E        A        +   A   + SP   E        C 
Sbjct: 723  QEVSTPSQARGEGSPSE--------ATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCH 774

Query: 457  KSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLP 516
            +S   +      P      A+G G  +  +    +      S+  T EL R P       
Sbjct: 775  QSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPV------ 828

Query: 517  SSWKYPTNAPGAFRVASRSPA---RTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFV 573
            +       +P A  +A+R  A   R+  A+L    LP  G LR    +        S+F 
Sbjct: 829  TGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLP--GSLRDHSHQAEASS--DSIF- 883

Query: 574  LSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPAL--------PRPSRSSPGLYT 625
                           S   P+S  +VP LPK A   SP          PR  R + G   
Sbjct: 884  --------------HSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGTEL 929

Query: 626  SPGQDSLQPTAVSPPYGGDISPVS-PSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPT 684
            S   +  +P   +P     ++P + P     P++  +P PS S +    E +   E +P 
Sbjct: 930  SRRHNWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSP-PSPSNKREEEEEEFNFEVIPP 988

Query: 685  SPPWTPGASRPPSSL 699
             P ++     P  +L
Sbjct: 989  PPEFSNDPEPPAPAL 1003



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 37/115 (32%), Positives = 48/115 (41%), Gaps = 21/115 (18%)

Query: 789 PPPPPPPPPPPPR------MRSPQPARPGSA---------AVPGAAFAPIPRSPLPA--G 831
           PPPPP P P PP+        SP P+ P +A           P  + AP P   L A   
Sbjct: 140 PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSP 199

Query: 832 PSSCTSPRSPLP---APPRPFLYRRSPTDSDVSLDSEDSGAKSPGILGYNICPRG 883
           P + +SP  P P    PP P L   +P    V   +  + A SP  +G  + P G
Sbjct: 200 PHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPA-SPHTVGTRLFPPG 253


>gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Homo
           sapiens]
          Length = 1188

 Score = 83.6 bits (205), Expect = 8e-16
 Identities = 95/337 (28%), Positives = 131/337 (38%), Gaps = 40/337 (11%)

Query: 522 PTNAPGAFRVASRSPARTP-PASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEP 580
           P  APG  +  S  P  +P P+       P   +L P P   PP    P   VL  +  P
Sbjct: 144 PGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPP---PPSMAPPPPPVLEALSPP 200

Query: 581 AKVSPRAASPAKPSSLDLVPNLPKGAL--PPSPALPRPSRSSPGLYTSPGQDSLQPTAVS 638
             +S    SP+ P+  D +P  P  A   PP P +P P+  +P    + G     P  V+
Sbjct: 201 HTLS----SPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVT 256

Query: 639 PPYGGDIS----PVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTS---PPWTPG 691
             +  D++        +RA  PR+   P+ S    N      +   + P S   PP TP 
Sbjct: 257 K-WKSDVALNGRQAEATRASPPRSPAEPKGSALGPNP-----EPHLTFPRSFKVPPPTPV 310

Query: 692 ASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPPPMSPSWSERSVSPLRPETEARPPSR 751
            +      +   +P   E   G++  +P  LP PP    S+  R  S + P+    P   
Sbjct: 311 RTSSIPVQEAQEAPRKEE---GATKKAPSRLPLPP----SFHIRPASQVYPDRAPEPDCP 363

Query: 752 QLQALLARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQPARPG 811
                 A       + +S +   AG   P P  PP APP PPP PP PP   +P      
Sbjct: 364 GELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPP--AAPPLPCAQ 421

Query: 812 SAAVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAPPRP 848
            AA P A F   P+S  PA          P P PP P
Sbjct: 422 KAAHPPAGFTKTPKSSSPA--------LKPKPNPPSP 450



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 187/817 (22%), Positives = 268/817 (32%), Gaps = 177/817 (21%)

Query: 55  PAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSI 114
           P PPP     P  D+++      + L +P S +   PP   +   PP ++ P   P+   
Sbjct: 140 PPPPPGPAPGPPQDISE--PPGGSPLPSPPSTAPPPPPLL-LEPPPPPSMAPPPPPVLEA 196

Query: 115 QQNSSEAQLPSNGTGP----ASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTF 170
                    PS  T P     + P    A   P  PA               P    S  
Sbjct: 197 LSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAP-------------APPAPASPH 243

Query: 171 SREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQ---EMSGRAAATTPTKVYSEVHF 227
           +    L P      + + S   L   Q      S  +   E  G A    P     E H 
Sbjct: 244 TVGTRLFPPGG--VTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNP-----EPHL 296

Query: 228 TLAK-----PPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPA--PQPPSL--- 277
           T  +     PP+ V  ++ P          + + +P  E     +KAP+  P PPS    
Sbjct: 297 TFPRSFKVPPPTPVRTSSIP--------VQEAQEAPRKEEGAT-KKAPSRLPLPPSFHIR 347

Query: 278 ------PDRSPRPQ--RHIMSRSPMVERRMMGQ-RSPASERR------------------ 310
                 PDR+P P     + + +P   R  +GQ +S A ER                   
Sbjct: 348 PASQVYPDRAPEPDCPGELKATAPASPR--LGQSQSQADERAGTPPPAPPLPPPAPPLPP 405

Query: 311 ---PLGNFTAPPTYTETLSTAPLASWVRSPPSYS-VLYPSSDPKSSHLKGQAVPA----- 361
              PL    APP      +  P A + ++P S S  L P  +P S      + P      
Sbjct: 406 PAPPLPP-AAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDP 464

Query: 362 SKTGILEESMARR--GSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEE 419
           S+   L   +A    GSR+       +P  T  P      Q+ + K+  R      + E+
Sbjct: 465 SQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAP------QSKEGKKGPR------LPEK 512

Query: 420 PFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGK 479
              L   A +    P      S   +     E A  L  P +   P+  P  ++ +    
Sbjct: 513 ETLLSLPAKD---TPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRN- 568

Query: 480 GAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPART 539
             EL AR  S  EK    S    P     P P +      +   N     +++       
Sbjct: 569 --ELEARLSSAAEKEAKPSIGSLP-----PKPRLE---GGRICENGADDDKLSKPVAKNL 618

Query: 540 PPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLV 599
           PP S           L P  + QP   L P++        P K +P  A P K +     
Sbjct: 619 PPQST---------TLLPTTSLQPKAMLGPAI--------PPKATPEPAIPPKATLWPAT 661

Query: 600 PNLPKGALPPS--------PALPRPSRSSPGLY----TSPGQDS-LQPTAVSPPYGGDIS 646
           P  PK  L P+        P  P  + S P +     T P   S L     S P G    
Sbjct: 662 P--PKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEK 719

Query: 647 PVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPP---------S 697
           P S   +   +A+    PS +TR   +  Q  R S    P  +PG    P         S
Sbjct: 720 PASQEVSTPSQARGEGSPSEATR---LPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQS 776

Query: 698 SLDGWVSP--------GPWEPGRGSSMSSPPPLPPPPPMSPSWSERSV-SPLRPETEARP 748
           SL   V+         G   PG    +  PP LP  PP S   ++  +  P+  E   R 
Sbjct: 777 SLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERG 836

Query: 749 PSRQLQALLARNIINAARRKSASPRSAGAENPRPFSP 785
               L        + AAR+++   RS GA   R   P
Sbjct: 837 SPMAL--------LLAARQRAQKGRSVGAALGRSSLP 865



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 154/658 (23%), Positives = 211/658 (32%), Gaps = 132/658 (20%)

Query: 265 FGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTET 324
           +G+    P PP  P  +P P + I                P     P    TAPP     
Sbjct: 133 YGQDLLIPPPP--PGPAPGPPQDI-------------SEPPGGSPLPSPPSTAPPPPPLL 177

Query: 325 LSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFV 384
           L   P  S    PP   VL   S P +  L   ++P     I             +    
Sbjct: 178 LEPPPPPSMAPPPPP--VLEALSPPHT--LSSPSIPTPPDFI--------PPAPPLAFLA 225

Query: 385 EKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAA 444
             P   P P             R    G V   +   AL    +   +   PR  A P  
Sbjct: 226 PPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKG 285

Query: 445 AEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPE 504
           +  + P     L  PR    P P P +  S    +  E   + +   +K         P 
Sbjct: 286 SA-LGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKK--------APS 336

Query: 505 LARCPSPTMSLPSSWKYPTNAPGAF---RVASRSPARTPPASLYHGYLPEN-GVLRPEPT 560
               P      P+S  YP  AP       + + +PA +P          E  G   P P 
Sbjct: 337 RLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPA-SPRLGQSQSQADERAGTPPPAPP 395

Query: 561 KQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSS 620
             PP           P+  PA   P AA P        +P   K A PP+     P  SS
Sbjct: 396 LPPP---------APPLPPPAPPLPPAAPP--------LPCAQKAAHPPAGFTKTPKSSS 438

Query: 621 PGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAW-SPRAKQAPRPSFSTRNAGIEAQDRR 679
           P L   P   S + TA S P             W  P   +  R   +    G   +DR 
Sbjct: 439 PALKPKPNPPSPENTASSAPVD-----------WRDPSQMEKLRNELAAYLCGSRREDRF 487

Query: 680 ESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMS-----SPPPLPPPPPMSPSWSE 734
            S        PG +  P S +G    GP  P + + +S     +PP +P       S +E
Sbjct: 488 LS------HRPGPTVAPQSKEG--KKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTE 539

Query: 735 RSVSP--------LRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAENPRP---- 782
              +P          P+    P  RQ++  L   + +AA  K A P S G+  P+P    
Sbjct: 540 TEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAA-EKEAKP-SIGSLPPKPRLEG 597

Query: 783 ------------FSPPRAPPPPPPPP---------------PPPPRMRSPQPARPGSAAV 815
                        S P A   PP                  P  P   +P+PA P  A +
Sbjct: 598 GRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATL 657

Query: 816 PGAAFAPIPRSPL-PAGPSSCTS-PRSPLPAPPRPFLYRRS---PTDSDVSLDSEDSG 868
             A     P++ L PA P   TS P +PL A   P +   +   PT +   +  +DSG
Sbjct: 658 WPAT---PPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSG 712



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 62/223 (27%), Positives = 74/223 (33%), Gaps = 57/223 (25%)

Query: 686 PPWTPG-ASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPPPMSPSWSERSVSPLRPET 744
           PP  PG A  PP  +       P      ++   PP L  PPP              P +
Sbjct: 140 PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPP--------------PPS 185

Query: 745 EARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSPPR------APPPPPPPPPP 798
            A PP   L+AL   + ++          S     P  F PP       APPPPP P P 
Sbjct: 186 MAPPPPPVLEALSPPHTLS----------SPSIPTPPDFIPPAPPLAFLAPPPPPVPAPA 235

Query: 799 PPRMRSPQPA-----RPG-------SAAVPG----AAFAPIPRSPL--------PAGPSS 834
           PP   SP         PG         A+ G    A  A  PRSP         P     
Sbjct: 236 PPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPH 295

Query: 835 CTSPRSPLPAPPRPFLYRRSPTDSDVSLDSEDSGA--KSPGIL 875
            T PRS    PP P      P         ++ GA  K+P  L
Sbjct: 296 LTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRL 338



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 51/182 (28%), Positives = 59/182 (32%), Gaps = 50/182 (27%)

Query: 704 SPGPWEPGR-GSSMSSPPPLPPPPPMSPSWSER----SVSPLRPETEARPPSRQLQALLA 758
           S G   PG+ G  +  PPP P P P  P         S  P  P T   PP   L+    
Sbjct: 124 SVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLE---- 179

Query: 759 RNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPP---PPPPPPRMRSPQPARPGS--A 813
                                  P  PP   PPPPP      PP  + SP    P     
Sbjct: 180 -----------------------PPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIP 216

Query: 814 AVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAPPRPFLYRRSPT------DSDVSLDSEDS 867
             P  AF   P  P+PA       P  P PA P     R  P        SDV+L+   +
Sbjct: 217 PAPPLAFLAPPPPPVPA-------PAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQA 269

Query: 868 GA 869
            A
Sbjct: 270 EA 271



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 148/675 (21%), Positives = 235/675 (34%), Gaps = 103/675 (15%)

Query: 55   PAPPPAEVHSPAAD---VNQNLASPSATLT-TPTSNS-----SHNPPATD-------VNQ 98
            P PPPA    PAA      Q  A P A  T TP S+S       NPP+ +       V+ 
Sbjct: 402  PLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDW 461

Query: 99   NPPATVVPQSLPLSSIQQNSS-EAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLI 157
              P+ +      L++    S  E +  S+  GP   P +      P+ P +E    TLL 
Sbjct: 462  RDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKE----TLL- 516

Query: 158  DKVSTPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATT 217
               S PA  T          P   P  S   SS    +  P+  + S D          +
Sbjct: 517  ---SLPAKDT----------PPGVPEKSLGGSSLTETEAAPSLTLPSVDY-----IPQDS 558

Query: 218  PTKVYSEVHFTL-AKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPS 276
            PT    ++   L A+  S   + A+P  I +     ++E   + E     +K   P   +
Sbjct: 559  PTPSVRQIRNELEARLSSAAEKEAKP-SIGSLPPKPRLEGGRICENGADDDKLSKPVAKN 617

Query: 277  LPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRS 336
            LP +S      ++  + +  + M+G   PA   +       PP  T   +T P A+   +
Sbjct: 618  LPPQSTT----LLPTTSLQPKAMLG---PAIPPKATPEPAIPPKATLWPATPPKATLGPA 670

Query: 337  PPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLL 396
             P  +   P++  K++   G A+ ++ T +   +      + S       P   P     
Sbjct: 671  TPLKATSGPTTPLKAT--SGPAIASTATTLPTTTSQLMAEKDS------GPAGQPEKPAS 722

Query: 397  DLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCL 456
              V T  + R +    E        A        +   A   + SP   E        C 
Sbjct: 723  QEVSTPSQARGEGSPSE--------ATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCH 774

Query: 457  KSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLP 516
            +S   +      P      A+G G  +  +    +      S+  T EL R P       
Sbjct: 775  QSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPV------ 828

Query: 517  SSWKYPTNAPGAFRVASRSPA---RTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFV 573
            +       +P A  +A+R  A   R+  A+L    LP  G LR    +        S+F 
Sbjct: 829  TGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLP--GSLRDHSHQAEASS--DSIF- 883

Query: 574  LSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPAL--------PRPSRSSPGLYT 625
                           S   P+S  +VP LPK A   SP          PR  R + G   
Sbjct: 884  --------------HSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGTEL 929

Query: 626  SPGQDSLQPTAVSPPYGGDISPVS-PSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPT 684
            S   +  +P   +P     ++P + P     P++  +P PS S +    E +   E +P 
Sbjct: 930  SRRHNWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSP-PSPSNKREEEEEEFNFEVIPP 988

Query: 685  SPPWTPGASRPPSSL 699
             P ++     P  +L
Sbjct: 989  PPEFSNDPEPPAPAL 1003



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 37/115 (32%), Positives = 48/115 (41%), Gaps = 21/115 (18%)

Query: 789 PPPPPPPPPPPPR------MRSPQPARPGSA---------AVPGAAFAPIPRSPLPA--G 831
           PPPPP P P PP+        SP P+ P +A           P  + AP P   L A   
Sbjct: 140 PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSP 199

Query: 832 PSSCTSPRSPLP---APPRPFLYRRSPTDSDVSLDSEDSGAKSPGILGYNICPRG 883
           P + +SP  P P    PP P L   +P    V   +  + A SP  +G  + P G
Sbjct: 200 PHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPA-SPHTVGTRLFPPG 253


>gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo
           sapiens]
          Length = 1188

 Score = 83.6 bits (205), Expect = 8e-16
 Identities = 95/337 (28%), Positives = 131/337 (38%), Gaps = 40/337 (11%)

Query: 522 PTNAPGAFRVASRSPARTP-PASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEP 580
           P  APG  +  S  P  +P P+       P   +L P P   PP    P   VL  +  P
Sbjct: 144 PGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPP---PPSMAPPPPPVLEALSPP 200

Query: 581 AKVSPRAASPAKPSSLDLVPNLPKGAL--PPSPALPRPSRSSPGLYTSPGQDSLQPTAVS 638
             +S    SP+ P+  D +P  P  A   PP P +P P+  +P    + G     P  V+
Sbjct: 201 HTLS----SPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVT 256

Query: 639 PPYGGDIS----PVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTS---PPWTPG 691
             +  D++        +RA  PR+   P+ S    N      +   + P S   PP TP 
Sbjct: 257 K-WKSDVALNGRQAEATRASPPRSPAEPKGSALGPNP-----EPHLTFPRSFKVPPPTPV 310

Query: 692 ASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPPPMSPSWSERSVSPLRPETEARPPSR 751
            +      +   +P   E   G++  +P  LP PP    S+  R  S + P+    P   
Sbjct: 311 RTSSIPVQEAQEAPRKEE---GATKKAPSRLPLPP----SFHIRPASQVYPDRAPEPDCP 363

Query: 752 QLQALLARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQPARPG 811
                 A       + +S +   AG   P P  PP APP PPP PP PP   +P      
Sbjct: 364 GELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPP--AAPPLPCAQ 421

Query: 812 SAAVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAPPRP 848
            AA P A F   P+S  PA          P P PP P
Sbjct: 422 KAAHPPAGFTKTPKSSSPA--------LKPKPNPPSP 450



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 187/817 (22%), Positives = 268/817 (32%), Gaps = 177/817 (21%)

Query: 55  PAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSI 114
           P PPP     P  D+++      + L +P S +   PP   +   PP ++ P   P+   
Sbjct: 140 PPPPPGPAPGPPQDISE--PPGGSPLPSPPSTAPPPPPLL-LEPPPPPSMAPPPPPVLEA 196

Query: 115 QQNSSEAQLPSNGTGP----ASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTF 170
                    PS  T P     + P    A   P  PA               P    S  
Sbjct: 197 LSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAP-------------APPAPASPH 243

Query: 171 SREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQ---EMSGRAAATTPTKVYSEVHF 227
           +    L P      + + S   L   Q      S  +   E  G A    P     E H 
Sbjct: 244 TVGTRLFPPGG--VTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNP-----EPHL 296

Query: 228 TLAK-----PPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPA--PQPPSL--- 277
           T  +     PP+ V  ++ P          + + +P  E     +KAP+  P PPS    
Sbjct: 297 TFPRSFKVPPPTPVRTSSIP--------VQEAQEAPRKEEGAT-KKAPSRLPLPPSFHIR 347

Query: 278 ------PDRSPRPQ--RHIMSRSPMVERRMMGQ-RSPASERR------------------ 310
                 PDR+P P     + + +P   R  +GQ +S A ER                   
Sbjct: 348 PASQVYPDRAPEPDCPGELKATAPASPR--LGQSQSQADERAGTPPPAPPLPPPAPPLPP 405

Query: 311 ---PLGNFTAPPTYTETLSTAPLASWVRSPPSYS-VLYPSSDPKSSHLKGQAVPA----- 361
              PL    APP      +  P A + ++P S S  L P  +P S      + P      
Sbjct: 406 PAPPLPP-AAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDP 464

Query: 362 SKTGILEESMARR--GSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEE 419
           S+   L   +A    GSR+       +P  T  P      Q+ + K+  R      + E+
Sbjct: 465 SQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAP------QSKEGKKGPR------LPEK 512

Query: 420 PFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGK 479
              L   A +    P      S   +     E A  L  P +   P+  P  ++ +    
Sbjct: 513 ETLLSLPAKD---TPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRN- 568

Query: 480 GAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPART 539
             EL AR  S  EK    S    P     P P +      +   N     +++       
Sbjct: 569 --ELEARLSSAAEKEAKPSIGSLP-----PKPRLE---GGRICENGADDDKLSKPVAKNL 618

Query: 540 PPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLV 599
           PP S           L P  + QP   L P++        P K +P  A P K +     
Sbjct: 619 PPQST---------TLLPTTSLQPKAMLGPAI--------PPKATPEPAIPPKATLWPAT 661

Query: 600 PNLPKGALPPS--------PALPRPSRSSPGLY----TSPGQDS-LQPTAVSPPYGGDIS 646
           P  PK  L P+        P  P  + S P +     T P   S L     S P G    
Sbjct: 662 P--PKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEK 719

Query: 647 PVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPP---------S 697
           P S   +   +A+    PS +TR   +  Q  R S    P  +PG    P         S
Sbjct: 720 PASQEVSTPSQARGEGSPSEATR---LPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQS 776

Query: 698 SLDGWVSP--------GPWEPGRGSSMSSPPPLPPPPPMSPSWSERSV-SPLRPETEARP 748
           SL   V+         G   PG    +  PP LP  PP S   ++  +  P+  E   R 
Sbjct: 777 SLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERG 836

Query: 749 PSRQLQALLARNIINAARRKSASPRSAGAENPRPFSP 785
               L        + AAR+++   RS GA   R   P
Sbjct: 837 SPMAL--------LLAARQRAQKGRSVGAALGRSSLP 865



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 154/658 (23%), Positives = 211/658 (32%), Gaps = 132/658 (20%)

Query: 265 FGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTET 324
           +G+    P PP  P  +P P + I                P     P    TAPP     
Sbjct: 133 YGQDLLIPPPP--PGPAPGPPQDI-------------SEPPGGSPLPSPPSTAPPPPPLL 177

Query: 325 LSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFV 384
           L   P  S    PP   VL   S P +  L   ++P     I             +    
Sbjct: 178 LEPPPPPSMAPPPPP--VLEALSPPHT--LSSPSIPTPPDFI--------PPAPPLAFLA 225

Query: 385 EKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAA 444
             P   P P             R    G V   +   AL    +   +   PR  A P  
Sbjct: 226 PPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKG 285

Query: 445 AEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPE 504
           +  + P     L  PR    P P P +  S    +  E   + +   +K         P 
Sbjct: 286 SA-LGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKK--------APS 336

Query: 505 LARCPSPTMSLPSSWKYPTNAPGAF---RVASRSPARTPPASLYHGYLPEN-GVLRPEPT 560
               P      P+S  YP  AP       + + +PA +P          E  G   P P 
Sbjct: 337 RLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPA-SPRLGQSQSQADERAGTPPPAPP 395

Query: 561 KQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSS 620
             PP           P+  PA   P AA P        +P   K A PP+     P  SS
Sbjct: 396 LPPP---------APPLPPPAPPLPPAAPP--------LPCAQKAAHPPAGFTKTPKSSS 438

Query: 621 PGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAW-SPRAKQAPRPSFSTRNAGIEAQDRR 679
           P L   P   S + TA S P             W  P   +  R   +    G   +DR 
Sbjct: 439 PALKPKPNPPSPENTASSAPVD-----------WRDPSQMEKLRNELAAYLCGSRREDRF 487

Query: 680 ESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMS-----SPPPLPPPPPMSPSWSE 734
            S        PG +  P S +G    GP  P + + +S     +PP +P       S +E
Sbjct: 488 LS------HRPGPTVAPQSKEG--KKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTE 539

Query: 735 RSVSP--------LRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAENPRP---- 782
              +P          P+    P  RQ++  L   + +AA  K A P S G+  P+P    
Sbjct: 540 TEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAA-EKEAKP-SIGSLPPKPRLEG 597

Query: 783 ------------FSPPRAPPPPPPPP---------------PPPPRMRSPQPARPGSAAV 815
                        S P A   PP                  P  P   +P+PA P  A +
Sbjct: 598 GRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATL 657

Query: 816 PGAAFAPIPRSPL-PAGPSSCTS-PRSPLPAPPRPFLYRRS---PTDSDVSLDSEDSG 868
             A     P++ L PA P   TS P +PL A   P +   +   PT +   +  +DSG
Sbjct: 658 WPAT---PPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSG 712



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 62/223 (27%), Positives = 74/223 (33%), Gaps = 57/223 (25%)

Query: 686 PPWTPG-ASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPPPMSPSWSERSVSPLRPET 744
           PP  PG A  PP  +       P      ++   PP L  PPP              P +
Sbjct: 140 PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPP--------------PPS 185

Query: 745 EARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSPPR------APPPPPPPPPP 798
            A PP   L+AL   + ++          S     P  F PP       APPPPP P P 
Sbjct: 186 MAPPPPPVLEALSPPHTLS----------SPSIPTPPDFIPPAPPLAFLAPPPPPVPAPA 235

Query: 799 PPRMRSPQPA-----RPG-------SAAVPG----AAFAPIPRSPL--------PAGPSS 834
           PP   SP         PG         A+ G    A  A  PRSP         P     
Sbjct: 236 PPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPH 295

Query: 835 CTSPRSPLPAPPRPFLYRRSPTDSDVSLDSEDSGA--KSPGIL 875
            T PRS    PP P      P         ++ GA  K+P  L
Sbjct: 296 LTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRL 338



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 51/182 (28%), Positives = 59/182 (32%), Gaps = 50/182 (27%)

Query: 704 SPGPWEPGR-GSSMSSPPPLPPPPPMSPSWSER----SVSPLRPETEARPPSRQLQALLA 758
           S G   PG+ G  +  PPP P P P  P         S  P  P T   PP   L+    
Sbjct: 124 SVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLE---- 179

Query: 759 RNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPP---PPPPPPRMRSPQPARPGS--A 813
                                  P  PP   PPPPP      PP  + SP    P     
Sbjct: 180 -----------------------PPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIP 216

Query: 814 AVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAPPRPFLYRRSPT------DSDVSLDSEDS 867
             P  AF   P  P+PA       P  P PA P     R  P        SDV+L+   +
Sbjct: 217 PAPPLAFLAPPPPPVPA-------PAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQA 269

Query: 868 GA 869
            A
Sbjct: 270 EA 271



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 148/675 (21%), Positives = 235/675 (34%), Gaps = 103/675 (15%)

Query: 55   PAPPPAEVHSPAAD---VNQNLASPSATLT-TPTSNS-----SHNPPATD-------VNQ 98
            P PPPA    PAA      Q  A P A  T TP S+S       NPP+ +       V+ 
Sbjct: 402  PLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDW 461

Query: 99   NPPATVVPQSLPLSSIQQNSS-EAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLI 157
              P+ +      L++    S  E +  S+  GP   P +      P+ P +E    TLL 
Sbjct: 462  RDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKE----TLL- 516

Query: 158  DKVSTPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATT 217
               S PA  T          P   P  S   SS    +  P+  + S D          +
Sbjct: 517  ---SLPAKDT----------PPGVPEKSLGGSSLTETEAAPSLTLPSVDY-----IPQDS 558

Query: 218  PTKVYSEVHFTL-AKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPS 276
            PT    ++   L A+  S   + A+P  I +     ++E   + E     +K   P   +
Sbjct: 559  PTPSVRQIRNELEARLSSAAEKEAKP-SIGSLPPKPRLEGGRICENGADDDKLSKPVAKN 617

Query: 277  LPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRS 336
            LP +S      ++  + +  + M+G   PA   +       PP  T   +T P A+   +
Sbjct: 618  LPPQSTT----LLPTTSLQPKAMLG---PAIPPKATPEPAIPPKATLWPATPPKATLGPA 670

Query: 337  PPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLL 396
             P  +   P++  K++   G A+ ++ T +   +      + S       P   P     
Sbjct: 671  TPLKATSGPTTPLKAT--SGPAIASTATTLPTTTSQLMAEKDS------GPAGQPEKPAS 722

Query: 397  DLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCL 456
              V T  + R +    E        A        +   A   + SP   E        C 
Sbjct: 723  QEVSTPSQARGEGSPSE--------ATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCH 774

Query: 457  KSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLP 516
            +S   +      P      A+G G  +  +    +      S+  T EL R P       
Sbjct: 775  QSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPV------ 828

Query: 517  SSWKYPTNAPGAFRVASRSPA---RTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFV 573
            +       +P A  +A+R  A   R+  A+L    LP  G LR    +        S+F 
Sbjct: 829  TGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLP--GSLRDHSHQAEASS--DSIF- 883

Query: 574  LSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPAL--------PRPSRSSPGLYT 625
                           S   P+S  +VP LPK A   SP          PR  R + G   
Sbjct: 884  --------------HSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGTEL 929

Query: 626  SPGQDSLQPTAVSPPYGGDISPVS-PSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPT 684
            S   +  +P   +P     ++P + P     P++  +P PS S +    E +   E +P 
Sbjct: 930  SRRHNWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSP-PSPSNKREEEEEEFNFEVIPP 988

Query: 685  SPPWTPGASRPPSSL 699
             P ++     P  +L
Sbjct: 989  PPEFSNDPEPPAPAL 1003



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 37/115 (32%), Positives = 48/115 (41%), Gaps = 21/115 (18%)

Query: 789 PPPPPPPPPPPPR------MRSPQPARPGSA---------AVPGAAFAPIPRSPLPA--G 831
           PPPPP P P PP+        SP P+ P +A           P  + AP P   L A   
Sbjct: 140 PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSP 199

Query: 832 PSSCTSPRSPLP---APPRPFLYRRSPTDSDVSLDSEDSGAKSPGILGYNICPRG 883
           P + +SP  P P    PP P L   +P    V   +  + A SP  +G  + P G
Sbjct: 200 PHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPA-SPHTVGTRLFPPG 253


>gi|160707881 formin 2 [Homo sapiens]
          Length = 1722

 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 117/410 (28%), Positives = 133/410 (32%), Gaps = 67/410 (16%)

Query: 497  ESSSHTPELARCPSPTMSLPSSW--KYPTNA---PGAFRVASRSPARTPPASLYHGYLPE 551
            ESSS  P L   P P   LP       P+ A   P   +     P   PP       LP 
Sbjct: 865  ESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPP-------LPG 917

Query: 552  NGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKP----SSLDLVPNLPKGAL 607
             G+  P P   P   + P   +      P    P AA P  P    + + L P LP   +
Sbjct: 918  AGI--PPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGI 975

Query: 608  PPSPALPR----PSRSSPGLYTSPGQDSLQPTAVSPPY---GGDISPVSPSRAWSPRAKQ 660
            PP P LP     P    PG    P    L    + PP    G  I P  P     P A  
Sbjct: 976  PPPPPLPGAGIPPPPPLPGAGIPP-PPPLPGAGIPPPPPLPGAGIPPPPPL----PGAGI 1030

Query: 661  APRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPP 720
             P P      AGI         P  PP       PP  L G   P P  P  G+ +  PP
Sbjct: 1031 PPPPPLP--GAGI---------PPPPPLPGAGIPPPPPLPGAGIPPP-PPLPGAGIPPPP 1078

Query: 721  PLP----PPPPMSPSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAG 776
            PLP    PPPP  P        PL P     PP           +  A          AG
Sbjct: 1079 PLPGAGIPPPPPLPGAGIPPPPPL-PGVGIPPPPP---------LPGAGIPPPPPLPGAG 1128

Query: 777  AENPRPFSPPRAPPPPP-------PPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLP 829
               P P      PPPPP       PPPP P     P P  PG+   P      +   P P
Sbjct: 1129 IPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPP 1188

Query: 830  AGPSSCTSPRSPLPA----PPRPFLYRRSPTDSDVSLDSEDSGAKSPGIL 875
              P     P  PLP     PP P      P      L    +G   P +L
Sbjct: 1189 PLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLL 1238



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 93/320 (29%), Positives = 112/320 (35%), Gaps = 39/320 (12%)

Query: 558  EPTKQPPYQLRPSL------FVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSP 611
            +P  QPP+ +           V S  K    +      P   SS  + P L  G +PP P
Sbjct: 824  QPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSM-PGL--GMVPPPP 880

Query: 612  ALPRPSRSSPGLYTS--PGQDSLQPTAVSPPY-----GGDISPVSPSRAWSPRAKQAPRP 664
              P P  + P L ++  P    LQ T + PP      G  I P  P     P A   P P
Sbjct: 881  P-PLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPL----PGAGILPLP 935

Query: 665  SFSTRNAGIEAQDRRESLPTSPPWTPGASRP-PSSLDGWVSPGPWEPGRGSSMSSPPPLP 723
                            ++P  PP  PGA  P P  L G   P P  P  G+ +  PPPLP
Sbjct: 936  PLPGAGIPPPPPLPGAAIPPPPP-LPGAGIPLPPPLPGAGIPPP-PPLPGAGIPPPPPLP 993

Query: 724  ----PPPPMSPSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPR-SAGAE 778
                PPPP  P        PL       PP      +     +  A      P   AG  
Sbjct: 994  GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1053

Query: 779  NPRPFSPPRAPPPPP-------PPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAG 831
             P P      PPPPP       PPPP P     P P  PG+   P      +   P P  
Sbjct: 1054 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPL 1113

Query: 832  PSSCTSPRSPLPA---PPRP 848
            P +   P  PLP    PP P
Sbjct: 1114 PGAGIPPPPPLPGAGIPPPP 1133



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 87/303 (28%), Positives = 100/303 (33%), Gaps = 66/303 (21%)

Query: 549  LPENGVLRPEPTKQ---PPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKG 605
            LP  G+  P P      PP    P   +  P   P    P    P   + +   P LP  
Sbjct: 1014 LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP-PPPPLPGAGIPPPPPLPGA 1072

Query: 606  ALPPSPALPR----PSRSSPGLYTSPGQDSLQPTAVSPPY---GGDISPVSPSRAWSPRA 658
             +PP P LP     P    PG    P    L    + PP    G  I P  P     P A
Sbjct: 1073 GIPPPPPLPGAGIPPPPPLPGAGIPP-PPPLPGVGIPPPPPLPGAGIPPPPPL----PGA 1127

Query: 659  KQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSS 718
               P P      AGI         P  PP       PP  L G   P P  P  G+ +  
Sbjct: 1128 GIPPPPPLP--GAGI---------PPPPPLPRVGIPPPPPLPGAGIPPP-PPLPGAGIPP 1175

Query: 719  PPPLP----PPPPMSPSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRS 774
            PPPLP    PPPP  P        PL P     PP                      P  
Sbjct: 1176 PPPLPGVGIPPPPPLPGVGIPPPPPL-PGAGIPPP----------------------PPL 1212

Query: 775  AGAENPRPFSPPRAPP----PPPP--PPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPL 828
             G   P   +PP  PP    PPPP  P   PP +  PQ    GS+ +P          PL
Sbjct: 1213 PGMGIPPAPAPPLPPPGTGIPPPPLLPVSGPPLL--PQ---VGSSTLPTPQVCGFLPPPL 1267

Query: 829  PAG 831
            P+G
Sbjct: 1268 PSG 1270



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 57/214 (26%), Positives = 73/214 (34%), Gaps = 38/214 (17%)

Query: 668 TRNAGIEAQDRRESLPTSPPWTPGASRPP-----SSLDGWVSPGPWEPGRGSSMSSPPPL 722
           T   G+      + LP  PP  PGA   P     S +   VSP        S   +    
Sbjct: 749 TEEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSIS 808

Query: 723 PPPPPMSPSWSERSVSPLRPETEARPP---SRQLQALLARNIINAARRKS--ASPRSAGA 777
            PPPP S  WS     P      ++PP   S + Q     ++ +A +      SP     
Sbjct: 809 QPPPPPSLLWSAGQGQP-----GSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPC 863

Query: 778 ENPRPFSPPRAPPPPPPPP--------------PPPPRMRSPQPARPGSAAVPGAAFAPI 823
                  P     PPPPPP              P PP ++  +   P    +PGA   P 
Sbjct: 864 TESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPP 923

Query: 824 PR------SPLPAGPSSCTSPRSPLPA---PPRP 848
           P        PLP  P +   P  PLP    PP P
Sbjct: 924 PPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPP 957



 Score = 30.4 bits (67), Expect = 7.8
 Identities = 71/305 (23%), Positives = 102/305 (33%), Gaps = 42/305 (13%)

Query: 375 GSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEP 434
           GS   +++F      T   DLL  +Q A   ++Q+ Q           L  +    QQ+ 
Sbjct: 178 GSDTDIYSF---HSATEQEDLLSDIQQAIRLQQQQQQ----------QLQLQLQQQQQQQ 224

Query: 435 APRDRASPAAAEEVV-PEWASCLKSPRI---------QAKPKPKPNQNLSEASGKGAELY 484
             +    PAA    V P+  + L   R          +A   P   Q LS  S     L 
Sbjct: 225 QLQGAEEPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLA 284

Query: 485 ARRQSRMEKYVIESS--SHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPA 542
           A  +   +         S  P L          PSS  +P    G    A+ +P R    
Sbjct: 285 AEPREPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGD 344

Query: 543 SLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNL 602
           +   G   E       P   P  +  P +   +P +   +    A  P  P++       
Sbjct: 345 TDEEG---EEDAFEDAPRGSPGEEWAPEVGEDAPQRLGEEPEEEAQGPDAPAA------- 394

Query: 603 PKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAP 662
              +LP SPA P      P    +P         +S P   + SP S S   SPR K+ P
Sbjct: 395 --ASLPGSPA-PSQRCFKPYPLITPCYIKTTTRQLSSP---NHSP-SQSPNQSPRIKRRP 447

Query: 663 RPSFS 667
            PS S
Sbjct: 448 EPSLS 452


>gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens]
          Length = 1970

 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 105/385 (27%), Positives = 142/385 (36%), Gaps = 25/385 (6%)

Query: 498  SSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRP 557
            SS + P      SP+ S P+S  Y   +PG +    +SP+ +P +  Y    P      P
Sbjct: 1578 SSPYIPSPGGAMSPSYS-PTSPAYEPRSPGGY--TPQSPSYSPTSPSYSPTSPSYSPTSP 1634

Query: 558  E--PTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPA-KPSSLDLVPNLPKGALPPSPALP 614
               PT        PS    SP   P   S    SP+  P+S    P  P      SP  P
Sbjct: 1635 NYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSY----SPTSP 1690

Query: 615  RPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIE 674
              S +SP    SP   S  PT  SP Y    SP SPS + +  +     PS+S  +    
Sbjct: 1691 SYSPTSPSY--SPTSPSYSPT--SPSY----SPTSPSYSPTSPSYSPTSPSYSPTSPSYS 1742

Query: 675  AQDRRESLPTSPPWTPGASR--PPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPPPMSPSW 732
                  S PTSP +TP +    P S      SP         S +SP   P  P  SP+ 
Sbjct: 1743 PTSPNYS-PTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPTS 1801

Query: 733  SERSVSPLR--PETEARPPSRQLQALLARNIINAARRKSASPRSAGAENPR--PFSPPRA 788
               S S  R  P++    PS    +  + +    + + + +  S    +P   P SP  +
Sbjct: 1802 PSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPKYS 1861

Query: 789  PPPPPPPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAPPRP 848
            P  P   P  P    +     P +      +    P SP+    S   SP SP  +P  P
Sbjct: 1862 PTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTSP 1921

Query: 849  FLYRRSPTDSDVSLDSEDSGAKSPG 873
                 SPT S  S         SPG
Sbjct: 1922 KYSPTSPTYSPTSPKGSTYSPTSPG 1946



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 87/310 (28%), Positives = 122/310 (39%), Gaps = 25/310 (8%)

Query: 575  SPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPS--PALPRPSRSSPGLYT------S 626
            SP   P   SP +  P+ P     +P+ P GA+ PS  P  P     SPG YT      S
Sbjct: 1562 SPAWSPTPGSPGSPGPSSP----YIPS-PGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYS 1616

Query: 627  PGQDSLQPTAVS-PPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTS 685
            P   S  PT+ S  P   + SP SPS + +  +     PS+S  +          S PTS
Sbjct: 1617 PTSPSYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYS-PTS 1675

Query: 686  PPWTPGASRPPSSLDGWVSPGPWEPGRG-SSMSSPPPLPPPPPMSPSWSERSVSPLRPET 744
            P ++P +   PS      S  P  P    +S S  P  P   P SPS+S  S S   P +
Sbjct: 1676 PSYSPTS---PSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS-YSPTS 1731

Query: 745  EARPPSRQLQALLARNIINAARRKSASPRSAGAENPR--PFSPPRAPPPPPPPPPPPPRM 802
             +  P+    +  + N    +   + +  S    +P   P SP   P  P   P  P   
Sbjct: 1732 PSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYS 1791

Query: 803  RSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAPPRPFLYRRSPTDSDVSL 862
             +     P S +   ++    P+SP     S   SP SP  +P  P   + +PT    S 
Sbjct: 1792 PTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSP---KYTPTSPSYSP 1848

Query: 863  DSEDSGAKSP 872
             S +    SP
Sbjct: 1849 SSPEYTPTSP 1858



 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 78/281 (27%), Positives = 104/281 (37%), Gaps = 28/281 (9%)

Query: 584  SPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGG 643
            SP   S   P +    P+    A   SP        +PG   SPG  S  P   SP  GG
Sbjct: 1532 SPSVGSGMTPGAAGFSPSAASDASGFSPGYSPAWSPTPGSPGSPGPSS--PYIPSP--GG 1587

Query: 644  DISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTP-GASRPPSSLDGW 702
             +SP     ++SP +     P++  R+ G          PTSP ++P   S  P+S +  
Sbjct: 1588 AMSP-----SYSPTS-----PAYEPRSPGGYTPQSPSYSPTSPSYSPTSPSYSPTSPNYS 1637

Query: 703  VSPGPWEPGRGSSMSSPPPLPPPPPMSPSWS--ERSVSPLRPETEARPPSRQLQALLARN 760
             +   + P   +S S  P  P   P SPS+S    S SP  P      PS         +
Sbjct: 1638 PTSPSYSP---TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYS-----PTS 1689

Query: 761  IINAARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQPARPGSAAVPGAAF 820
               +    S SP S       P   P +P   P  P   P   S  P  P S +     +
Sbjct: 1690 PSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSP-SYSPTSPNY 1748

Query: 821  APIPRSPLPAGPSSCTSPRSPLPAPPRPFLYRRSPTDSDVS 861
            +P   +  P  PS   SP SP  +P  P     SP  S  S
Sbjct: 1749 SPTSPNYTPTSPS--YSPTSPSYSPTSPNYTPTSPNYSPTS 1787



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 47/175 (26%), Positives = 63/175 (36%), Gaps = 9/175 (5%)

Query: 696  PSSLDGWVSPGPWEPGRGSSMSSPPPLPPP--------PPMSPSWSERSVSPLRPETEAR 747
            P+++ G  + GP     GS+ S    + P          P   +WS    S + P     
Sbjct: 1487 PTNIPGLGAAGPTGMFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGF 1546

Query: 748  PPSRQLQAL-LARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQ 806
             PS    A   +     A      SP S G  +P   SP  A  P   P  P    RSP 
Sbjct: 1547 SPSAASDASGFSPGYSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPG 1606

Query: 807  PARPGSAAVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAPPRPFLYRRSPTDSDVS 861
               P S +    + +  P SP  +  S   SP SP  +P  P     SP+ S  S
Sbjct: 1607 GYTPQSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTS 1661


>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
          Length = 904

 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 146/593 (24%), Positives = 217/593 (36%), Gaps = 120/593 (20%)

Query: 256 RSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMG------------QR 303
           RS    RR    + P+P+  + P R P P RH  SRSP+  RR                R
Sbjct: 307 RSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSR 366

Query: 304 SPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKG-QAVPAS 362
           S +  ++P    ++PP  T  LS +      R  PS     P   PK+ H    Q    +
Sbjct: 367 SRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPP---PKTRHSPTPQQSNRT 423

Query: 363 KTGILEESMARRGSRKSMFTFVEK---PKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEE 419
           +   +  S  R   + +     EK   P   P P  ++L ++ ++K  +    +   +  
Sbjct: 424 RKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRR 483

Query: 420 PFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGK 479
            +         Q + +  D  S +++E+  P+  S +K+  +  + +  P+++ S +  K
Sbjct: 484 QYRR-------QNQQSSSDSGSSSSSEDERPK-RSHVKNGEVGRRRRHSPSRSASPSPRK 535

Query: 480 GAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPART 539
             +  + R  R                R PSP          PT          RSP+  
Sbjct: 536 RQKETSPRGRRR---------------RSPSPP---------PTRR-------RRSPSPA 564

Query: 540 PPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLV 599
           PP        P      P P   PP +  PS         P + SP       PS     
Sbjct: 565 PPPRRRRTPTPPPRRRTPSP---PPRRRSPS---------PRRYSPPIQRRYSPSP---- 608

Query: 600 PNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRA--WSPR 657
           P   + A PP P   R S S P           +  + SPP     SPV+  R+   S +
Sbjct: 609 PPKRRTASPPPPPKRRASPSPP---------PKRRVSHSPPPKQRSSPVTKRRSPSLSSK 659

Query: 658 AKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMS 717
            ++   PS STR A     ++R S P+  P  P  S  P             P R  + S
Sbjct: 660 HRKGSSPSRSTREARSPQPNKRHS-PSPRPRAPQTSSSPP------------PVRRGASS 706

Query: 718 SPPPLPPPPPMSPSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGA 777
           SP     P P        S  P+R  +    P +  +A  A     + RR S+S   +G 
Sbjct: 707 SPQRRQSPSP--------STRPIRRVSRTPEPKKIKKA--ASPSPQSVRRVSSSRSVSG- 755

Query: 778 ENPRPFSPPRAPPPPPPPPPPPPRMRSPQPARPGSAAVP-GAAFAPIPRSPLP 829
                 SP  A   PP PP P   ++S  P+   S AVP   A +P P SP P
Sbjct: 756 ------SPEPAAKKPPAPPSP---VQSQSPSTNWSPAVPVKKAKSPTP-SPSP 798



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 158/674 (23%), Positives = 234/674 (34%), Gaps = 131/674 (19%)

Query: 255 ERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRP-LG 313
           ERS    RR    ++P+P+  S P R  R + H  SRSP   R      SPA E++    
Sbjct: 167 ERSRSPRRRK--SRSPSPRRRSSPVRRERKRSH--SRSPR-HRTKSRSPSPAPEKKEKTP 221

Query: 314 NFTAP------PTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGIL 367
               P      P+  E  ST+ +    +  P      PS +  S   K +     ++   
Sbjct: 222 ELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSR 281

Query: 368 EESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEA 427
            +S +R  SR    T   +P+                 RR R +             + +
Sbjct: 282 SKSRSRTRSRSPSHT---RPR-----------------RRHRSR-------------SRS 308

Query: 428 SNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARR 487
            + ++ P+PR R SP       P         R    P  +  ++ +  SG  +   + R
Sbjct: 309 YSPRRRPSPRRRPSPR--RRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSR 366

Query: 488 QSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHG 547
                K   + +S  P   R  SP+ S P     P            SP  TPP    H 
Sbjct: 367 SRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRP------------SPPATPPPKTRHS 414

Query: 548 YLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPR-------AASPA-KPSSLDLV 599
                      PT Q   + R S   +SP +   KV+         + SPA KP  ++L 
Sbjct: 415 -----------PTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELS 463

Query: 600 PNLPK--GALPPSPALPR---------PSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPV 648
            +     G +  + ++ +          S S  G  +S   +  + + V     G     
Sbjct: 464 ESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRH 523

Query: 649 SPSRAWSP---------------RAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGAS 693
           SPSR+ SP               R   +P P+   R+       RR   PT PP     S
Sbjct: 524 SPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPS 583

Query: 694 RPPSSLDGWVSPGPWEPGRGSSMS-SPPPL-----PPPPPMSPSWSERSVSPLRPETEAR 747
            PP       SP  + P      S SPPP      PPPPP   +    S  P R  + + 
Sbjct: 584 PPPRRRSP--SPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRA--SPSPPPKRRVSHSP 639

Query: 748 PPSRQLQALLARNI--INAARRKSASPRSAGAE--NPRPF-----SPPRAPPPPPPPPPP 798
           PP ++   +  R    +++  RK +SP  +  E  +P+P      SP    P     PPP
Sbjct: 640 PPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPP 699

Query: 799 PPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAPPRPFLYRRSPTDS 858
             R  S  P R  S +        + R+P P         +    A P P   RR  +  
Sbjct: 700 VRRGASSSPQRRQSPSPSTRPIRRVSRTPEP--------KKIKKAASPSPQSVRRVSSSR 751

Query: 859 DVSLDSEDSGAKSP 872
            VS   E +  K P
Sbjct: 752 SVSGSPEPAAKKPP 765



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 71/266 (26%), Positives = 103/266 (38%), Gaps = 44/266 (16%)

Query: 652 RAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPG 711
           R+ SPR +++  PS   R++ +  + +R    +    T   S  P+      +P   EP 
Sbjct: 168 RSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPS 227

Query: 712 ---------RGSSMSS------PPPLPPPPPMSP---SWSERSVSPLRPETEARPPSRQL 753
                      +S S       P P+P P   SP   S  E+     RP + +R  SR  
Sbjct: 228 VKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSR 287

Query: 754 QALLARNIINAARR-----KSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSP-QP 807
               + +     RR     +S SPR   +   RP    R PP   PPPP   R RSP + 
Sbjct: 288 TRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRR 347

Query: 808 ARPGSAAVPGAAFAPI---PRSPLPAGPSSCTSP------RSPLPAPPR----------- 847
            R  SA++ G++ +      RSP    P   +SP       SP  +PPR           
Sbjct: 348 RRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATP 407

Query: 848 PFLYRRSPTDSDVSLDSEDSGAKSPG 873
           P   R SPT    +   +   + SPG
Sbjct: 408 PPKTRHSPTPQQSNRTRKSRVSVSPG 433



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 114/488 (23%), Positives = 166/488 (34%), Gaps = 91/488 (18%)

Query: 400 QTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSP 459
           Q  D+ +R +++ E   E+   +         + P+PR R+SP   E       S  +SP
Sbjct: 147 QDEDKDKRDKEEKESSREKRERSRSPRRRK-SRSPSPRRRSSPVRRERK----RSHSRSP 201

Query: 460 RIQAK---PKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTM--- 513
           R + K   P P P     E   K  EL        E  V E++S T ++ + P P     
Sbjct: 202 RHRTKSRSPSPAP-----EKKEKTPELPEPSVKVKEPSVQEATS-TSDILKVPKPEPIPE 255

Query: 514 -SLPSSWKYP--------------TNAPGAFRVASRSPARTPPA----SLYHGYLPENGV 554
              PS  K                + +    R  SRSP+ T P     S    Y P    
Sbjct: 256 PKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRR-- 313

Query: 555 LRPEPTKQP-PYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPAL 613
            RP P ++P P +  P   +  P +     SP        +SL    +    +   SP  
Sbjct: 314 -RPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPK 372

Query: 614 PRPSRSSPGLYTSPGQDS--LQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNA 671
             P R+S     SP + +  L P+A SPP        SP     P+ + +P P  S R  
Sbjct: 373 KPPKRTS-----SPPRKTRRLSPSA-SPPRRRHRP--SPPATPPPKTRHSPTPQQSNRT- 423

Query: 672 GIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPPPMSPS 731
                 R+  +  SP  T G        +                 SP P P P  +  S
Sbjct: 424 ------RKSRVSVSPGRTSGKVTKHKGTE--------------KRESPSPAPKPRKVELS 463

Query: 732 WSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSAS---PRSAGAENPRPFSPPRA 788
            SE          ++    RQ +    ++  ++    S+    P+ +  +N       R 
Sbjct: 464 ESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRH 523

Query: 789 PPPPPPPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAPPRP 848
            P     P P  R +   P                 RSP    P      RSP PAPP  
Sbjct: 524 SPSRSASPSPRKRQKETSPRGRRR------------RSP---SPPPTRRRRSPSPAPP-- 566

Query: 849 FLYRRSPT 856
              RR+PT
Sbjct: 567 PRRRRTPT 574



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 140/614 (22%), Positives = 209/614 (34%), Gaps = 117/614 (19%)

Query: 55  PAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQ---------------- 98
           P P      SP     ++ AS S + ++ +S+ S +PP     +                
Sbjct: 334 PPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSAS 393

Query: 99  --------NPPATVVPQSLPLSSIQQN-----SSEAQLPSNGTGPASK-PSTLCADGQPQ 144
                   +PPAT  P++    + QQ+     S  +  P   +G  +K   T   +    
Sbjct: 394 PPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSP 453

Query: 145 AP-AEEVRCSTLLIDKVSTPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVV 203
           AP   +V  S    DK    A   S   R       ++  +SD  SSS   D +P    V
Sbjct: 454 APKPRKVELSESEEDKGGKMAAADSVQQRR-QYRRQNQQSSSDSGSSSSSEDERPKRSHV 512

Query: 204 SADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERR 263
              +   GR    +P++  S         PS   R        +P G  +   SP   RR
Sbjct: 513 KNGE--VGRRRRHSPSRSAS---------PSPRKRQKE----TSPRGRRRRSPSPPPTRR 557

Query: 264 HFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQR--SPASERR-----PLGNFT 316
               ++P+P PP    R+P P     + SP   RR    R  SP  +RR     P    T
Sbjct: 558 ---RRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRT 614

Query: 317 A----PPTYTETLSTAPLASWVRSPPSYSVLYP-----SSDPKSSHLKGQAVPASKTGIL 367
           A    PP    + S  P      SPP      P     S    S H KG + P+  T   
Sbjct: 615 ASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSS-PSRST--R 671

Query: 368 EESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQ------RDQGEVGVEEEPF 421
           E    +   R S       P+ + +P  +    ++  +RRQ      R    V    EP 
Sbjct: 672 EARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPK 731

Query: 422 ALGAEASNFQQ-------------EPAPRDRASPAAAEEVVPEWASCLKSPRIQAK---- 464
            +   AS   Q              P P  +  PA    V  +  S   SP +  K    
Sbjct: 732 KIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKS 791

Query: 465 --PKPKPNQNL-SEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKY 521
             P P P +N   E  GK  +    ++ + +K   +   H  E A   +   ++      
Sbjct: 792 PTPSPSPPRNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAV------ 845

Query: 522 PTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSP-IKEP 580
               P A   A+ + A+  P            V  PEP K+   +   +L  L   ++E 
Sbjct: 846 ---TPAAIAAATTTLAQEEP------------VAAPEPKKETESEAEDNLDDLEKHLREK 890

Query: 581 AKVSPRAASPAKPS 594
           A  S R A  +  S
Sbjct: 891 ALRSMRKAQVSPQS 904



 Score = 38.5 bits (88), Expect = 0.028
 Identities = 139/644 (21%), Positives = 208/644 (32%), Gaps = 112/644 (17%)

Query: 49  EAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQS 108
           +++  SPAP   E      + +  +  PS    T TS+    P    + +  P    P+ 
Sbjct: 206 KSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPE--PKEPSPEK 263

Query: 109 LPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTS 168
              +S ++   E   P + +   S+  T         P    R  +        P+    
Sbjct: 264 ---NSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRR 320

Query: 169 TFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFT 228
              R  T      PP     S S +   + ++  +S     S  + + +P K        
Sbjct: 321 PSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPK-------- 372

Query: 229 LAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSL-----PDRSPR 283
             KPP    RT+ P     P  T ++  S    RR      PA  PP       P +S R
Sbjct: 373 --KPPK---RTSSP-----PRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNR 422

Query: 284 PQRHIMSRSPM-----------VERRMMGQRSPA--------SERRPLGNFTAPPTYTET 324
            ++  +S SP             E+R     +P         SE    G   A  +  + 
Sbjct: 423 TRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQR 482

Query: 325 LSTAPLASWVRSPPSYSVLYPSSDPKSSHLKG------------QAVPASKTGILEESMA 372
                      S    S       PK SH+K             ++   S     +E+  
Sbjct: 483 RQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSP 542

Query: 373 RRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQ 432
           R   R+S      + + +P+P        A   RR+R          P          ++
Sbjct: 543 RGRRRRSPSPPPTRRRRSPSP--------APPPRRRRTPTPPPRRRTP-----SPPPRRR 589

Query: 433 EPAPRDRASPAAAEEVVPE------WASCLKSPRIQAKPKPKPNQNLSEA---SGKGAEL 483
            P+PR R SP       P        AS    P+ +A P P P + +S +     + + +
Sbjct: 590 SPSPR-RYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPV 648

Query: 484 YARRQ----------SRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVAS 533
             RR           S   +   E+ S  P     PSP    P +   P   P   R AS
Sbjct: 649 TKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSP---PPVRRGAS 705

Query: 534 RSPARTPPASLYHGYLPENGVLR-PEPTK---------QPPYQLRPSLFVLSPIKEPAKV 583
            SP R    S      P   V R PEP K         Q   ++  S  V    +  AK 
Sbjct: 706 SSPQRRQSPS--PSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKK 763

Query: 584 SPRAASPAKPSS--LDLVPNLP--KGALP-PSPALPRPSRSSPG 622
            P   SP +  S   +  P +P  K   P PSP+ PR S    G
Sbjct: 764 PPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEGG 807



 Score = 37.0 bits (84), Expect = 0.083
 Identities = 56/258 (21%), Positives = 89/258 (34%), Gaps = 49/258 (18%)

Query: 48  REAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNS---------SHNPPATDVNQ 98
           R  +  SPAPPP    +P     +   SP     +P+            S +PP      
Sbjct: 556 RRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTA 615

Query: 99  NPPATVVPQSLPLSSIQQNSSEAQLPSNGTGPASK---PSTLCADGQPQAPAEEVRCSTL 155
           +PP     ++ P    ++  S +  P   + P +K   PS      +  +P+   R    
Sbjct: 616 SPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTR---- 671

Query: 156 LIDKVSTPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAA 215
                   A +     R +   PS RP A             P T   S+      R A+
Sbjct: 672 -------EARSPQPNKRHS---PSPRPRA-------------PQT---SSSPPPVRRGAS 705

Query: 216 TTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPP 275
           ++P +  S    T  +P   V+RT  P  I+          SP   RR    ++ +  P 
Sbjct: 706 SSPQRRQSPSPST--RPIRRVSRTPEPKKIKKAASP-----SPQSVRRVSSSRSVSGSPE 758

Query: 276 SLPDRSPRPQRHIMSRSP 293
               + P P   + S+SP
Sbjct: 759 PAAKKPPAPPSPVQSQSP 776


>gi|60460889 Myb protein P42POP [Homo sapiens]
          Length = 399

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 86/290 (29%), Positives = 117/290 (40%), Gaps = 54/290 (18%)

Query: 581 AKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPR----------PSRSSPGLYTSPGQD 630
           A + P  A+P   +  +  P  P    PP  A P+            R+    ++  G  
Sbjct: 118 AILGPGVAAPGAGAGAEEPPAAPSSQPPPPSACPQRYVLSEDRREDRRADTSAHSKAGSS 177

Query: 631 SLQPTA---VSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPP 687
           S +P A    +P  GG            P+ +++P PS     A    Q  R +L   PP
Sbjct: 178 SPEPWARPSCTPQEGG---------CPRPKERESPPPS-----ALQPVQLPRLALSPPPP 223

Query: 688 WTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPPPMSPSWSERSVSPLRPETEAR 747
             P    PP +    V+P P          SPPP PP PP + S S+ S+  LR + E  
Sbjct: 224 APPLPPPPPLAQ---VAPSP---------PSPPP-PPRPPPTLSASDPSLDFLRAQQETA 270

Query: 748 PPSRQLQALLARNIINAARRKSAS-PRSAGAENPRPFSPPRAPPPPPPPPPPPPRMR--- 803
              R+L   L + +   +   SA  P   G   P    PP  PPPPPPPPPP P +    
Sbjct: 271 NAIRELAGTLRQGLAKLSEALSALLPLLPGT--PVDSLPPPLPPPPPPPPPPRPVLPPPA 328

Query: 804 -----SPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAPPRP 848
                +P+P    +A V GA  A   R  + A  S   +PR P PAP  P
Sbjct: 329 PKVEITPEPVSVVAAVVDGAVVA--ARGVIIAPRSEEGAPRPP-PAPLPP 375



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 86/304 (28%), Positives = 111/304 (36%), Gaps = 49/304 (16%)

Query: 526 PGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLR-PSLFVLSPIK-EPAKV 583
           PG     + + A  PPA+               P+ QPP     P  +VLS  + E  + 
Sbjct: 122 PGVAAPGAGAGAEEPPAA---------------PSSQPPPPSACPQRYVLSEDRREDRRA 166

Query: 584 SPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPT-----AVS 638
              A S A  SS +  P       P     PRP         SP   +LQP      A+S
Sbjct: 167 DTSAHSKAGSSSPE--PWARPSCTPQEGGCPRPKERE-----SPPPSALQPVQLPRLALS 219

Query: 639 PPYGGDISPVSPSRAW------SPRAKQAPRPSFSTRNAGIE---AQDRRESLPTSPPWT 689
           PP      P  P  A       SP     P P+ S  +  ++   AQ    +       T
Sbjct: 220 PPPPAPPLPPPPPLAQVAPSPPSPPPPPRPPPTLSASDPSLDFLRAQQETANAIRELAGT 279

Query: 690 --PGASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPPPMSPSWSERSVSPLRPETEAR 747
              G ++   +L   +   P  PG     S PPPLPPPPP  P      + P  P+ E  
Sbjct: 280 LRQGLAKLSEALSALL---PLLPGTPVD-SLPPPLPPPPPPPPP-PRPVLPPPAPKVEIT 334

Query: 748 PPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQP 807
           P    + A +    + AAR    +PRS     PRP   P AP PP   PP   R   P  
Sbjct: 335 PEPVSVVAAVVDGAVVAARGVIIAPRSEEGA-PRP---PPAPLPPHDSPPHKRRKGFPTR 390

Query: 808 ARPG 811
            R G
Sbjct: 391 KRRG 394



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 85/323 (26%), Positives = 109/323 (33%), Gaps = 101/323 (31%)

Query: 667 STRNAGIEAQDR--------RESLPTSPPWTPGASRPPSSLDGW----------VSPGPW 708
           S +  G E Q R        +E L   P  T GA   P++ D +          + PG  
Sbjct: 68  SWKRTGQEVQKRWNDFKRRTKEKLARVPHSTQGAG--PAAEDAFSAEEETIFAILGPGVA 125

Query: 709 EPGRGSSMSSPPPLP---PPPPM-----------------------------SPS-WSER 735
            PG G+    PP  P   PPPP                              SP  W+  
Sbjct: 126 APGAGAGAEEPPAAPSSQPPPPSACPQRYVLSEDRREDRRADTSAHSKAGSSSPEPWARP 185

Query: 736 SVSPL-----RPETEARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSPPRA-- 788
           S +P      RP+    PP   LQ +          R + SP       P P  PP A  
Sbjct: 186 SCTPQEGGCPRPKERESPPPSALQPV-------QLPRLALSPPPPAPPLPPP--PPLAQV 236

Query: 789 ---PPPPPPPPPPPPRMRSPQPA---------------------RPGSAAVPGA--AFAP 822
              PP PPPPP PPP + +  P+                     R G A +  A  A  P
Sbjct: 237 APSPPSPPPPPRPPPTLSASDPSLDFLRAQQETANAIRELAGTLRQGLAKLSEALSALLP 296

Query: 823 I-PRSPLPAGPSSCTSPRSPLPAPPRPFLYRRSP----TDSDVSLDSEDSGAKSPGILGY 877
           + P +P+ + P     P  P P PPRP L   +P    T   VS+ +           G 
Sbjct: 297 LLPGTPVDSLPPPLPPPPPP-PPPPRPVLPPPAPKVEITPEPVSVVAAVVDGAVVAARGV 355

Query: 878 NICPRGWNGSLRLKRGSLPAEAS 900
            I PR   G+ R     LP   S
Sbjct: 356 IIAPRSEEGAPRPPPAPLPPHDS 378


>gi|41281612 zinc finger protein 828 [Homo sapiens]
          Length = 812

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 114/397 (28%), Positives = 149/397 (37%), Gaps = 59/397 (14%)

Query: 509 PSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPE---PTKQPPY 565
           P  +  LP   K P N        S  P   P  S+    L    VL PE   PT   P 
Sbjct: 105 PVKSPPLPEHQKIPCN--------SAEPKSIPALSMETQKL--GSVLSPESPKPTPLTPL 154

Query: 566 QLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLP-----KGALPPSPALPRPSRSS 620
           + +    V+SP  +    SP  + PA  SS +   ++P     K A  PSP   +P+  S
Sbjct: 155 EPQKPGSVVSPELQTPLPSPEPSKPASVSSPEPPKSVPVCESQKLAPVPSPEPQKPAPVS 214

Query: 621 PGLYTS------PGQDSLQPTAVSPPYGGDISPVSPSRA-----WSPRAKQAPRPSFSTR 669
           P    +      P + S  P  + PP     SP SP  A     W P    +P    S R
Sbjct: 215 PESVKATLSNPKPQKQSHFPETLGPPSAS--SPESPVLAASPEPWGPSPAASPESRKSAR 272

Query: 670 NAGIEAQDRRESLPTSP-PWT--PGASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPP 726
               E   R+ S   SP PW   P  S  P      VSPG W+PG       PP  P P 
Sbjct: 273 TTSPE--PRKPSPSESPEPWKPFPAVSPEPRRPAPAVSPGSWKPG-------PPGSPRPW 323

Query: 727 PMSPSWSERSVSPLRPETEARP-PSRQLQALLARNIINAARRKSASPRSAGAENPRPFSP 785
             +PS S     P +P     P P + + ++            SAS +S+   +P  +  
Sbjct: 324 KSNPSASSGPWKPAKPAPSVSPGPWKPIPSVSPGPWKPTPSVSSASWKSSSV-SPSSWKS 382

Query: 786 PRAPPPPPPPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAP 845
           P A P      PP  R  +P  +     AVP    +P  R P   GP      RSP  +P
Sbjct: 383 PPASPESWKSGPPELRKTAPTLSPEHWKAVP--PVSPELRKP---GPPLSPEIRSPAGSP 437

Query: 846 P------RPFLYRRSPTD---SDVSLDSEDSGAKSPG 873
                   P L++ SP     S  SLD  +S   S G
Sbjct: 438 ELRKPSGSPDLWKLSPDQRKTSPASLDFPESQKSSRG 474



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 99/375 (26%), Positives = 146/375 (38%), Gaps = 77/375 (20%)

Query: 436 PRDRASPAAAEEVVPEWASCLKSPRIQAKPKP-KPNQNLSEASGKGAELYARRQSRMEKY 494
           P+ +      E + P  AS  +SP + A P+P  P+   S  S K A   +    +    
Sbjct: 225 PKPQKQSHFPETLGPPSASSPESPVLAASPEPWGPSPAASPESRKSARTTSPEPRK---- 280

Query: 495 VIESSSHTPEL----------ARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTP---- 540
              S S +PE            R P+P +S P SWK     PG+ R    +P+ +     
Sbjct: 281 --PSPSESPEPWKPFPAVSPEPRRPAPAVS-PGSWK--PGPPGSPRPWKSNPSASSGPWK 335

Query: 541 PASLYHGYLPENGVLRPEPTKQP-PYQLRPSLFVLSPIKEPAKVSPRA--ASPAKPSSLD 597
           PA       P  G  +P P+  P P++  PS  V S   + + VSP +  + PA P S  
Sbjct: 336 PAKPAPSVSP--GPWKPIPSVSPGPWKPTPS--VSSASWKSSSVSPSSWKSPPASPESWK 391

Query: 598 ------------LVPNLPKGALPPSPALPRPSRS-SPGLYTSPGQDSLQPTAVSPPYGGD 644
                       L P   K   P SP L +P    SP + +  G   L+  + SP    D
Sbjct: 392 SGPPELRKTAPTLSPEHWKAVPPVSPELRKPGPPLSPEIRSPAGSPELRKPSGSP----D 447

Query: 645 ISPVSPS-RAWSPRAKQAPRPSFSTRNAG---------IEAQ-----DRRESLPTSPPWT 689
           +  +SP  R  SP +   P    S+R            IE Q     + R+  P+ P  +
Sbjct: 448 LWKLSPDQRKTSPASLDFPESQKSSRGGSPDLWKSSFFIEPQKPVFPETRKPGPSGPSES 507

Query: 690 PGAS----RPPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPPPMSPSWSERSVSPLRPETE 745
           P A+    +P  S+D        EP + +    P P    PP SP   +R++ P  P   
Sbjct: 508 PKAASDIWKPVLSIDT-------EPRKPALF--PEPAKTAPPASPEARKRALFP-EPRKH 557

Query: 746 ARPPSRQLQALLARN 760
           A  P     AL + +
Sbjct: 558 ALFPELPKSALFSES 572



 Score = 33.5 bits (75), Expect = 0.92
 Identities = 114/472 (24%), Positives = 167/472 (35%), Gaps = 75/472 (15%)

Query: 218 PTKVYSEVHFTLAKP---PSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQP 274
           P   + ++    A+P   P++   T +   + +P        +P+  ++     +P  Q 
Sbjct: 110 PLPEHQKIPCNSAEPKSIPALSMETQKLGSVLSPESPKPTPLTPLEPQKPGSVVSPELQT 169

Query: 275 PSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAP-PTYTETLSTAPLASW 333
           P LP  SP P +     SP   + +     P  E + L    +P P     +S   + + 
Sbjct: 170 P-LP--SPEPSKPASVSSPEPPKSV-----PVCESQKLAPVPSPEPQKPAPVSPESVKAT 221

Query: 334 VRSP-PSYSVLYPSS--DPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVT 390
           + +P P     +P +   P +S  +   + AS         A   SRKS  T   +P+  
Sbjct: 222 LSNPKPQKQSHFPETLGPPSASSPESPVLAASPEPWGPSPAASPESRKSARTTSPEPR-K 280

Query: 391 PNPD-----LLDLVQTADEKRRQRDQGEVGVEEE--PFALGAEASNFQQEPAPRDRASPA 443
           P+P             + E RR       G  +   P +     SN      P   A PA
Sbjct: 281 PSPSESPEPWKPFPAVSPEPRRPAPAVSPGSWKPGPPGSPRPWKSNPSASSGPWKPAKPA 340

Query: 444 AAEEVVPEWASCLKSPRIQAKPKP-KPNQNLSEASGKGAELYARRQSRMEKYVIESSSHT 502
            +    P W      P     P P KP  ++S AS K + +                S  
Sbjct: 341 PSVSPGP-W-----KPIPSVSPGPWKPTPSVSSASWKSSSVSPSSWKSPPASPESWKSGP 394

Query: 503 PELARCPSPTMSLPSSWK-YPTNAPGAFRVAS------RSPARTPPASLYHGYLPENGVL 555
           PEL R  +PT+S P  WK  P  +P   +         RSPA +P      G  P+   L
Sbjct: 395 PEL-RKTAPTLS-PEHWKAVPPVSPELRKPGPPLSPEIRSPAGSPELRKPSGS-PDLWKL 451

Query: 556 RPEPTKQPPYQL------------RPSLFVLSPIKEPAKV---------------SPRAA 588
            P+  K  P  L             P L+  S   EP K                SP+AA
Sbjct: 452 SPDQRKTSPASLDFPESQKSSRGGSPDLWKSSFFIEPQKPVFPETRKPGPSGPSESPKAA 511

Query: 589 SPA-KPS-SLDLVPNLPKGALPPSPALPRPSRS----SPGLYTSPGQDSLQP 634
           S   KP  S+D  P  P  AL P PA   P  S       L+  P + +L P
Sbjct: 512 SDIWKPVLSIDTEPRKP--ALFPEPAKTAPPASPEARKRALFPEPRKHALFP 561



 Score = 32.7 bits (73), Expect = 1.6
 Identities = 97/473 (20%), Positives = 149/473 (31%), Gaps = 98/473 (20%)

Query: 49  EAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQS 108
           E Q   P+P P++   PA+     ++SP    + P   S    P        PA V P+S
Sbjct: 166 ELQTPLPSPEPSK---PAS-----VSSPEPPKSVPVCESQKLAPVPSPEPQKPAPVSPES 217

Query: 109 L------PLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVST 162
           +      P    Q +  E   P + + P S    L A  +P  P               +
Sbjct: 218 VKATLSNPKPQKQSHFPETLGPPSASSPES--PVLAASPEPWGP---------------S 260

Query: 163 PATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVY 222
           PA +  +     T  P  R P+                            + +  P K +
Sbjct: 261 PAASPESRKSARTTSPEPRKPSP---------------------------SESPEPWKPF 293

Query: 223 SEVHFTLAKP-PSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQP-----PS 276
             V     +P P+V   + +P     PG     + +P      +    PAP         
Sbjct: 294 PAVSPEPRRPAPAVSPGSWKP---GPPGSPRPWKSNPSASSGPWKPAKPAPSVSPGPWKP 350

Query: 277 LPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGN----FTAPPTYTETLSTAPLAS 332
           +P  SP P +   S S    +      SP+S + P  +     + PP   +T  T     
Sbjct: 351 IPSVSPGPWKPTPSVSSASWK--SSSVSPSSWKSPPASPESWKSGPPELRKTAPTLSPEH 408

Query: 333 WVRSPPSYSVLYPSSDPKSSHLKGQA------VPASKTGILEESMARRGSRKSMFTFVEK 386
           W   PP    L     P S  ++  A       P+    + + S  +R +  +   F E 
Sbjct: 409 WKAVPPVSPELRKPGPPLSPEIRSPAGSPELRKPSGSPDLWKLSPDQRKTSPASLDFPES 468

Query: 387 PKVT--PNPDLLDLVQTADEKR----RQRDQGEVGVEEEP----------FALGAEASNF 430
            K +   +PDL       + ++      R  G  G  E P           ++  E    
Sbjct: 469 QKSSRGGSPDLWKSSFFIEPQKPVFPETRKPGPSGPSESPKAASDIWKPVLSIDTEPRKP 528

Query: 431 QQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAEL 483
              P P   A PA+ E       +    PR  A     P   L   S K  EL
Sbjct: 529 ALFPEPAKTAPPASPE---ARKRALFPEPRKHALFPELPKSALFSESQKAVEL 578


>gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 148/676 (21%), Positives = 231/676 (34%), Gaps = 122/676 (18%)

Query: 263  RHFGEKAPAPQPPSLPDRSPRPQRH----IMSRSPMVERRMMGQRSPASERRPLGNFTAP 318
            + +GE  P  +P   P    +P +     +  +  M  RR  G  S     R      A 
Sbjct: 537  KKYGELPPIEKPVDPPPFMFKPVKEEDDGLSGKHSMRTRRSRGSMSTLRSGRK--KQPAS 594

Query: 319  PTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRK 378
            P    +     + S  R+ PS      ++   S+  K + V  S   + EE+ +   S K
Sbjct: 595  PDGRTSPINEDIRSSGRNSPS------AASTSSNDSKAETVKKSAKKVKEEASSPLKSNK 648

Query: 379  SMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRD 438
                  ++ KV  + +  D   +   K ++  +     E E  +  + + N +    P+D
Sbjct: 649  R-----QREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKD 703

Query: 439  RASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIES 498
                  +            SP I   P P+ N++ S++S +   L A+  +      +  
Sbjct: 704  IDQDNRST-----------SPSI---PSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTP 749

Query: 499  --SSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPP--------ASLYHGY 548
              SS  P   + P+P  +  ++   P  +P A +  ++  A T P        A   H  
Sbjct: 750  APSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQ 809

Query: 549  LPENGVLRPEPTKQPPYQ--------------LRPSLFVLSPI-KEPAKVSPRAASPAKP 593
             P +    P P+  PP Q               +P L    P      +  P    P  P
Sbjct: 810  RPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPP 869

Query: 594  SSLDLVPNLPKGALP----PSPALPRPSRSSPGLYTS------PGQDSLQPTAVSPPYGG 643
                L P   +G  P    P+ A P  S   P   ++      P +  L P  ++ P+  
Sbjct: 870  QPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIK 929

Query: 644  DISPVSPSRAWSPRAKQAPR----PSFSTRNAGIE---AQDRRESLPTSPPWTPGASRPP 696
                    +  +P+A + P     PS  + NA +    A     SL T  P  P A  PP
Sbjct: 930  PPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHP--PSAHPPP 987

Query: 697  SSLDGWVSPGPWEPGRGSSMSSPPPLPPPPPMSPSWSERSVSPLRPETEARPPSRQLQAL 756
              L     P P  P +   ++    LPPPP   P      V+P       +PP  Q    
Sbjct: 988  LQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAP-------QPPFAQ---- 1036

Query: 757  LARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQPARPGSAA-- 814
                           P   G   P P +PP  P    PP  P     S QP   G+AA  
Sbjct: 1037 --------------HPFVPG--GPPPITPPTCPSTSTPPAGPG---TSAQPPCSGAAASG 1077

Query: 815  --VPGAAFAPIPRSPL-PAGPSSCTSPRSPLPAPPRPFLYRRSPTDSDVSLDSEDSGAKS 871
              + G +  P+P   +          P SP P P       RSP+     +D+    ++S
Sbjct: 1078 GSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPP-------RSPSPEPTVVDTPSHASQS 1130

Query: 872  PGIL-----GYNICPR 882
                     GYN C R
Sbjct: 1131 ARFYKHLDRGYNSCAR 1146



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 82/369 (22%), Positives = 127/369 (34%), Gaps = 68/369 (18%)

Query: 2   EGYSEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAE 61
           E  S   S  R  EKVAS+ EE       K     ++    +     E + S       E
Sbjct: 639 EASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRP--NSPSEGEGESSDSRSVNDE 696

Query: 62  VHSPAADVNQNLASPSATLTTPTSNSSHNPPATD---VNQNPPATVVPQSLPLSSIQQNS 118
             S   D++Q+  S S ++ +P  N S +  +     +   PPA   P  +  +      
Sbjct: 697 GSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPP 756

Query: 119 SEAQLPSNGTGPAS-------KPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFS 171
              QLP+ G  P++        P+   A  QPQAP                 A    T  
Sbjct: 757 GTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPT----------------APVPHTHI 800

Query: 172 REATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAK 231
           ++A  +   RPP+             P+       Q ++G A                  
Sbjct: 801 QQAPALHPQRPPSP---------HPPPHPSPHPPLQPLTGSAG----------------- 834

Query: 232 PPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSR 291
            PS  +    P   Q P G   ++  P+L+  H G     PQP  LP ++ + Q   +  
Sbjct: 835 QPSAPSHAQPPLHGQGPPGPHSLQAGPLLQ--HPG----PPQPFGLPPQASQGQAP-LGT 887

Query: 292 SPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLA-SWVRSPPSYSVLY---PSS 347
           SP         + PAS+       +  P   + L  APLA   ++ PP+  +     P +
Sbjct: 888 SPAAAYPHTSLQLPASQS---ALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQA 944

Query: 348 DPKSSHLKG 356
                HL G
Sbjct: 945 HKHPPHLSG 953



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 141/671 (21%), Positives = 224/671 (33%), Gaps = 143/671 (21%)

Query: 44   LSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPAT 103
            +S  R  ++  PA P        + +N+++ S      +  S SS++  A  V ++    
Sbjct: 581  MSTLRSGRKKQPASPDGRT----SPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKV 636

Query: 104  VVPQSLPL-SSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAE---EVRCSTLLIDK 159
                S PL S+ +Q    A         +SK +      +P +P+E   E   S  + D+
Sbjct: 637  KEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDE 696

Query: 160  VSTPATTTSTFSREAT-LIPSSRPPASDFMSSS--LLIDIQPNTL------VVSADQEMS 210
             S+        +R  +  IPS +   SD  SS+   ++  QP  L        +      
Sbjct: 697  GSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPP 756

Query: 211  GRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAP 270
            G     TP    S         P+      +P    AP   + ++++P L      ++ P
Sbjct: 757  GTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALH----PQRPP 812

Query: 271  APQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPL 330
            +P PP  P  SP P    ++ S        GQ S  S  +P  +   PP    +L   PL
Sbjct: 813  SPHPP--PHPSPHPPLQPLTGS-------AGQPSAPSHAQPPLHGQGPPG-PHSLQAGPL 862

Query: 331  ASWVRSPPSYSVLYPSSDPKSSHLKGQA-VPASKTGILEESMARRGSRKSMFTFVEKPKV 389
                  P  + +      P++S  +GQA +  S       +  +  + +S     + P+ 
Sbjct: 863  LQHPGPPQPFGL-----PPQAS--QGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPRE 915

Query: 390  TPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVV 449
             P P                          P       +   Q PAP+    P       
Sbjct: 916  QPLPP--------------------APLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPS 955

Query: 450  PEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCP 509
            P       +  +   P  KP  +LS                        S+H P L   P
Sbjct: 956  P----FSMNANLPPPPALKPLSSLSTHH-------------------PPSAHPPPLQLMP 992

Query: 510  SPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRP 569
              +  LPSS   P   PG  +  +  P   PPAS      P  G+ +  P  QPP+   P
Sbjct: 993  Q-SQPLPSS---PAQPPGLTQSQNLPP---PPAS-----HPPTGLHQVAP--QPPFAQHP 1038

Query: 570  SLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQ 629
                                         VP  P    PP+     PS S+P     PG 
Sbjct: 1039 ----------------------------FVPGGPPPITPPT----CPSTSTPP--AGPGT 1064

Query: 630  DSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWT 689
             +  P + +   GG I+  S            P P+   +   ++  +  ES P  PP +
Sbjct: 1065 SAQPPCSGAAASGGSIAGGS----------SCPLPTVQIKEEALDDAEEPES-PPPPPRS 1113

Query: 690  PGASRPPSSLD 700
            P  S  P+ +D
Sbjct: 1114 P--SPEPTVVD 1122


>gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 148/676 (21%), Positives = 231/676 (34%), Gaps = 122/676 (18%)

Query: 263  RHFGEKAPAPQPPSLPDRSPRPQRH----IMSRSPMVERRMMGQRSPASERRPLGNFTAP 318
            + +GE  P  +P   P    +P +     +  +  M  RR  G  S     R      A 
Sbjct: 537  KKYGELPPIEKPVDPPPFMFKPVKEEDDGLSGKHSMRTRRSRGSMSTLRSGRK--KQPAS 594

Query: 319  PTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRK 378
            P    +     + S  R+ PS      ++   S+  K + V  S   + EE+ +   S K
Sbjct: 595  PDGRTSPINEDIRSSGRNSPS------AASTSSNDSKAETVKKSAKKVKEEASSPLKSNK 648

Query: 379  SMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRD 438
                  ++ KV  + +  D   +   K ++  +     E E  +  + + N +    P+D
Sbjct: 649  R-----QREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKD 703

Query: 439  RASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIES 498
                  +            SP I   P P+ N++ S++S +   L A+  +      +  
Sbjct: 704  IDQDNRST-----------SPSI---PSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTP 749

Query: 499  --SSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPP--------ASLYHGY 548
              SS  P   + P+P  +  ++   P  +P A +  ++  A T P        A   H  
Sbjct: 750  APSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQ 809

Query: 549  LPENGVLRPEPTKQPPYQ--------------LRPSLFVLSPI-KEPAKVSPRAASPAKP 593
             P +    P P+  PP Q               +P L    P      +  P    P  P
Sbjct: 810  RPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPP 869

Query: 594  SSLDLVPNLPKGALP----PSPALPRPSRSSPGLYTS------PGQDSLQPTAVSPPYGG 643
                L P   +G  P    P+ A P  S   P   ++      P +  L P  ++ P+  
Sbjct: 870  QPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIK 929

Query: 644  DISPVSPSRAWSPRAKQAPR----PSFSTRNAGIE---AQDRRESLPTSPPWTPGASRPP 696
                    +  +P+A + P     PS  + NA +    A     SL T  P  P A  PP
Sbjct: 930  PPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHP--PSAHPPP 987

Query: 697  SSLDGWVSPGPWEPGRGSSMSSPPPLPPPPPMSPSWSERSVSPLRPETEARPPSRQLQAL 756
              L     P P  P +   ++    LPPPP   P      V+P       +PP  Q    
Sbjct: 988  LQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAP-------QPPFAQ---- 1036

Query: 757  LARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQPARPGSAA-- 814
                           P   G   P P +PP  P    PP  P     S QP   G+AA  
Sbjct: 1037 --------------HPFVPG--GPPPITPPTCPSTSTPPAGPG---TSAQPPCSGAAASG 1077

Query: 815  --VPGAAFAPIPRSPL-PAGPSSCTSPRSPLPAPPRPFLYRRSPTDSDVSLDSEDSGAKS 871
              + G +  P+P   +          P SP P P       RSP+     +D+    ++S
Sbjct: 1078 GSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPP-------RSPSPEPTVVDTPSHASQS 1130

Query: 872  PGIL-----GYNICPR 882
                     GYN C R
Sbjct: 1131 ARFYKHLDRGYNSCAR 1146



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 82/369 (22%), Positives = 127/369 (34%), Gaps = 68/369 (18%)

Query: 2   EGYSEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAE 61
           E  S   S  R  EKVAS+ EE       K     ++    +     E + S       E
Sbjct: 639 EASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRP--NSPSEGEGESSDSRSVNDE 696

Query: 62  VHSPAADVNQNLASPSATLTTPTSNSSHNPPATD---VNQNPPATVVPQSLPLSSIQQNS 118
             S   D++Q+  S S ++ +P  N S +  +     +   PPA   P  +  +      
Sbjct: 697 GSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPP 756

Query: 119 SEAQLPSNGTGPAS-------KPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFS 171
              QLP+ G  P++        P+   A  QPQAP                 A    T  
Sbjct: 757 GTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPT----------------APVPHTHI 800

Query: 172 REATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAK 231
           ++A  +   RPP+             P+       Q ++G A                  
Sbjct: 801 QQAPALHPQRPPSP---------HPPPHPSPHPPLQPLTGSAG----------------- 834

Query: 232 PPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSR 291
            PS  +    P   Q P G   ++  P+L+  H G     PQP  LP ++ + Q   +  
Sbjct: 835 QPSAPSHAQPPLHGQGPPGPHSLQAGPLLQ--HPG----PPQPFGLPPQASQGQAP-LGT 887

Query: 292 SPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLA-SWVRSPPSYSVLY---PSS 347
           SP         + PAS+       +  P   + L  APLA   ++ PP+  +     P +
Sbjct: 888 SPAAAYPHTSLQLPASQS---ALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQA 944

Query: 348 DPKSSHLKG 356
                HL G
Sbjct: 945 HKHPPHLSG 953



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 141/671 (21%), Positives = 224/671 (33%), Gaps = 143/671 (21%)

Query: 44   LSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPAT 103
            +S  R  ++  PA P        + +N+++ S      +  S SS++  A  V ++    
Sbjct: 581  MSTLRSGRKKQPASPDGRT----SPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKV 636

Query: 104  VVPQSLPL-SSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAE---EVRCSTLLIDK 159
                S PL S+ +Q    A         +SK +      +P +P+E   E   S  + D+
Sbjct: 637  KEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDE 696

Query: 160  VSTPATTTSTFSREAT-LIPSSRPPASDFMSSS--LLIDIQPNTL------VVSADQEMS 210
             S+        +R  +  IPS +   SD  SS+   ++  QP  L        +      
Sbjct: 697  GSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPP 756

Query: 211  GRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAP 270
            G     TP    S         P+      +P    AP   + ++++P L      ++ P
Sbjct: 757  GTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALH----PQRPP 812

Query: 271  APQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPL 330
            +P PP  P  SP P    ++ S        GQ S  S  +P  +   PP    +L   PL
Sbjct: 813  SPHPP--PHPSPHPPLQPLTGS-------AGQPSAPSHAQPPLHGQGPPG-PHSLQAGPL 862

Query: 331  ASWVRSPPSYSVLYPSSDPKSSHLKGQA-VPASKTGILEESMARRGSRKSMFTFVEKPKV 389
                  P  + +      P++S  +GQA +  S       +  +  + +S     + P+ 
Sbjct: 863  LQHPGPPQPFGL-----PPQAS--QGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPRE 915

Query: 390  TPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVV 449
             P P                          P       +   Q PAP+    P       
Sbjct: 916  QPLPP--------------------APLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPS 955

Query: 450  PEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCP 509
            P       +  +   P  KP  +LS                        S+H P L   P
Sbjct: 956  P----FSMNANLPPPPALKPLSSLSTHH-------------------PPSAHPPPLQLMP 992

Query: 510  SPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRP 569
              +  LPSS   P   PG  +  +  P   PPAS      P  G+ +  P  QPP+   P
Sbjct: 993  Q-SQPLPSS---PAQPPGLTQSQNLPP---PPAS-----HPPTGLHQVAP--QPPFAQHP 1038

Query: 570  SLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQ 629
                                         VP  P    PP+     PS S+P     PG 
Sbjct: 1039 ----------------------------FVPGGPPPITPPT----CPSTSTPP--AGPGT 1064

Query: 630  DSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWT 689
             +  P + +   GG I+  S            P P+   +   ++  +  ES P  PP +
Sbjct: 1065 SAQPPCSGAAASGGSIAGGS----------SCPLPTVQIKEEALDDAEEPES-PPPPPRS 1113

Query: 690  PGASRPPSSLD 700
            P  S  P+ +D
Sbjct: 1114 P--SPEPTVVD 1122


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.126    0.377 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,982,991
Number of Sequences: 37866
Number of extensions: 3848844
Number of successful extensions: 87223
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1172
Number of HSP's successfully gapped in prelim test: 2241
Number of HSP's that attempted gapping in prelim test: 22849
Number of HSP's gapped (non-prelim): 26495
length of query: 903
length of database: 18,247,518
effective HSP length: 111
effective length of query: 792
effective length of database: 14,044,392
effective search space: 11123158464
effective search space used: 11123158464
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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