Guide to the Human Genome
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Search of human proteins with 38026934

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11
isoform 2 [Homo sapiens]
         (1562 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof...  3117   0.0  
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo...  3022   0.0  
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo...   695   0.0  
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [...   447   e-125
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [...   447   e-125
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [...   413   e-115
gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isofo...   190   1e-47
gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isofor...   189   2e-47
gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isofor...   185   3e-46
gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isoofor...   185   3e-46
gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isofor...   184   4e-46
gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]       178   4e-44
gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]       178   4e-44
gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]       178   4e-44
gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens]    169   3e-41
gi|38373682 pleckstrin homology domain containing family G membe...   132   3e-30
gi|111154084 pleckstrin homology domain containing family G memb...   132   3e-30
gi|111154088 pleckstrin homology domain containing family G memb...   132   3e-30
gi|111154080 pleckstrin homology domain containing family G memb...   132   3e-30
gi|111154078 pleckstrin homology domain containing family G memb...   132   3e-30
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]               122   3e-27
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                   120   1e-26
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                   120   1e-26
gi|222080070 pleckstrin homology domain-containing family G memb...    96   2e-19
gi|222080068 pleckstrin homology domain-containing family G memb...    96   2e-19
gi|222080066 pleckstrin homology domain-containing family G memb...    96   2e-19
gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 ...    91   9e-18
gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 ...    89   3e-17
gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [H...    89   3e-17
gi|21735572 epithelial cell transforming sequence 2 oncogene pro...    86   4e-16

>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
            [Homo sapiens]
          Length = 1562

 Score = 3117 bits (8082), Expect = 0.0
 Identities = 1562/1562 (100%), Positives = 1562/1562 (100%)

Query: 1    MSVRLPQSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQKDQHGFGFT 60
            MSVRLPQSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQKDQHGFGFT
Sbjct: 1    MSVRLPQSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQKDQHGFGFT 60

Query: 61   VSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLL 120
            VSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLL
Sbjct: 61   VSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLL 120

Query: 121  GSSPSSMGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPPQRITGPKPLQDPEVQKHATQ 180
            GSSPSSMGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPPQRITGPKPLQDPEVQKHATQ
Sbjct: 121  GSSPSSMGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPPQRITGPKPLQDPEVQKHATQ 180

Query: 181  ILRNMLRQEEKELQRICEVYSRNPASLLEEQIEGARRRVTQLQLKIQQETGGSVDILPLY 240
            ILRNMLRQEEKELQRICEVYSRNPASLLEEQIEGARRRVTQLQLKIQQETGGSVDILPLY
Sbjct: 181  ILRNMLRQEEKELQRICEVYSRNPASLLEEQIEGARRRVTQLQLKIQQETGGSVDILPLY 240

Query: 241  GDTSQRPSEGRLSLDSQEGDSGLDSGTERFPSLSESLMNRNSVLSDPGLDSPRTSPVIMA 300
            GDTSQRPSEGRLSLDSQEGDSGLDSGTERFPSLSESLMNRNSVLSDPGLDSPRTSPVIMA
Sbjct: 241  GDTSQRPSEGRLSLDSQEGDSGLDSGTERFPSLSESLMNRNSVLSDPGLDSPRTSPVIMA 300

Query: 301  RVAQHHRRQGSDAAVPSTGDQGVDQSPKPLIIGPEEDYDPGYFNNESDIIFQDLEKLKSR 360
            RVAQHHRRQGSDAAVPSTGDQGVDQSPKPLIIGPEEDYDPGYFNNESDIIFQDLEKLKSR
Sbjct: 301  RVAQHHRRQGSDAAVPSTGDQGVDQSPKPLIIGPEEDYDPGYFNNESDIIFQDLEKLKSR 360

Query: 361  PAHLGVFLRYIFSQADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIP 420
            PAHLGVFLRYIFSQADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIP
Sbjct: 361  PAHLGVFLRYIFSQADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIP 420

Query: 421  EMLQAEIDSRLRNSEDARGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLD 480
            EMLQAEIDSRLRNSEDARGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLD
Sbjct: 421  EMLQAEIDSRLRNSEDARGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLD 480

Query: 481  GDPLRERQVAEKQLAALGDILSKYEEDRSAPMDFALNTYMSHAGIRLREARPSNTAEKAQ 540
            GDPLRERQVAEKQLAALGDILSKYEEDRSAPMDFALNTYMSHAGIRLREARPSNTAEKAQ
Sbjct: 481  GDPLRERQVAEKQLAALGDILSKYEEDRSAPMDFALNTYMSHAGIRLREARPSNTAEKAQ 540

Query: 541  SAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEV 600
            SAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEV
Sbjct: 541  SAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEV 600

Query: 601  KPGNVRNIIQHFENNQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSESLKGREE 660
            KPGNVRNIIQHFENNQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSESLKGREE
Sbjct: 601  KPGNVRNIIQHFENNQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSESLKGREE 660

Query: 661  MKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRSI 720
            MKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRSI
Sbjct: 661  MKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRSI 720

Query: 721  ESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQEVIN 780
            ESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQEVIN
Sbjct: 721  ESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQEVIN 780

Query: 781  ELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLR 840
            ELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLR
Sbjct: 781  ELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLR 840

Query: 841  EEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEA 900
            EEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEA
Sbjct: 841  EEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEA 900

Query: 901  ESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYV 960
            ESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYV
Sbjct: 901  ESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYV 960

Query: 961  NEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDK 1020
            NEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDK
Sbjct: 961  NEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDK 1020

Query: 1021 TLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDK 1080
            TLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDK
Sbjct: 1021 TLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDK 1080

Query: 1081 RAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPR 1140
            RAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPR
Sbjct: 1081 RAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPR 1140

Query: 1141 EPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQGKHQVLLEDPEQEGSAEEEE 1200
            EPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQGKHQVLLEDPEQEGSAEEEE
Sbjct: 1141 EPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQGKHQVLLEDPEQEGSAEEEE 1200

Query: 1201 LGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADSALEDVENLRHLILWSLLPGH 1260
            LGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADSALEDVENLRHLILWSLLPGH
Sbjct: 1201 LGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADSALEDVENLRHLILWSLLPGH 1260

Query: 1261 TMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGGEGDNTQLAGLEGERPEQEDM 1320
            TMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGGEGDNTQLAGLEGERPEQEDM
Sbjct: 1261 TMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGGEGDNTQLAGLEGERPEQEDM 1320

Query: 1321 GLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGGYKVVRKAEVAGSKVVPALPES 1380
            GLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGGYKVVRKAEVAGSKVVPALPES
Sbjct: 1321 GLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGGYKVVRKAEVAGSKVVPALPES 1380

Query: 1381 GQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAPMSPPQPDSLPAGQTEPQPQL 1440
            GQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAPMSPPQPDSLPAGQTEPQPQL
Sbjct: 1381 GQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAPMSPPQPDSLPAGQTEPQPQL 1440

Query: 1441 QGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKLNRLKDMELAHRELLKSLGGESSGG 1500
            QGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKLNRLKDMELAHRELLKSLGGESSGG
Sbjct: 1441 QGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKLNRLKDMELAHRELLKSLGGESSGG 1500

Query: 1501 TTPVGSFHTEAARWTDGSLSPPAKEPLASDSRNSHELGPCPEDGSDAPLEDSTADAAASP 1560
            TTPVGSFHTEAARWTDGSLSPPAKEPLASDSRNSHELGPCPEDGSDAPLEDSTADAAASP
Sbjct: 1501 TTPVGSFHTEAARWTDGSLSPPAKEPLASDSRNSHELGPCPEDGSDAPLEDSTADAAASP 1560

Query: 1561 GP 1562
            GP
Sbjct: 1561 GP 1562


>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
            [Homo sapiens]
          Length = 1522

 Score = 3022 bits (7834), Expect = 0.0
 Identities = 1522/1562 (97%), Positives = 1522/1562 (97%), Gaps = 40/1562 (2%)

Query: 1    MSVRLPQSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQKDQHGFGFT 60
            MSVRLPQSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQKDQHGFGFT
Sbjct: 1    MSVRLPQSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQKDQHGFGFT 60

Query: 61   VSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLL 120
            VSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLL
Sbjct: 61   VSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLL 120

Query: 121  GSSPSSMGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPPQRITGPKPLQDPEVQKHATQ 180
            GSSPSSMGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPPQRITGPKPLQDPEVQKHATQ
Sbjct: 121  GSSPSSMGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPPQRITGPKPLQDPEVQKHATQ 180

Query: 181  ILRNMLRQEEKELQRICEVYSRNPASLLEEQIEGARRRVTQLQLKIQQETGGSVDILPLY 240
            ILRNMLRQEEKELQ                                        DILPLY
Sbjct: 181  ILRNMLRQEEKELQ----------------------------------------DILPLY 200

Query: 241  GDTSQRPSEGRLSLDSQEGDSGLDSGTERFPSLSESLMNRNSVLSDPGLDSPRTSPVIMA 300
            GDTSQRPSEGRLSLDSQEGDSGLDSGTERFPSLSESLMNRNSVLSDPGLDSPRTSPVIMA
Sbjct: 201  GDTSQRPSEGRLSLDSQEGDSGLDSGTERFPSLSESLMNRNSVLSDPGLDSPRTSPVIMA 260

Query: 301  RVAQHHRRQGSDAAVPSTGDQGVDQSPKPLIIGPEEDYDPGYFNNESDIIFQDLEKLKSR 360
            RVAQHHRRQGSDAAVPSTGDQGVDQSPKPLIIGPEEDYDPGYFNNESDIIFQDLEKLKSR
Sbjct: 261  RVAQHHRRQGSDAAVPSTGDQGVDQSPKPLIIGPEEDYDPGYFNNESDIIFQDLEKLKSR 320

Query: 361  PAHLGVFLRYIFSQADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIP 420
            PAHLGVFLRYIFSQADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIP
Sbjct: 321  PAHLGVFLRYIFSQADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIP 380

Query: 421  EMLQAEIDSRLRNSEDARGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLD 480
            EMLQAEIDSRLRNSEDARGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLD
Sbjct: 381  EMLQAEIDSRLRNSEDARGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLD 440

Query: 481  GDPLRERQVAEKQLAALGDILSKYEEDRSAPMDFALNTYMSHAGIRLREARPSNTAEKAQ 540
            GDPLRERQVAEKQLAALGDILSKYEEDRSAPMDFALNTYMSHAGIRLREARPSNTAEKAQ
Sbjct: 441  GDPLRERQVAEKQLAALGDILSKYEEDRSAPMDFALNTYMSHAGIRLREARPSNTAEKAQ 500

Query: 541  SAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEV 600
            SAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEV
Sbjct: 501  SAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEV 560

Query: 601  KPGNVRNIIQHFENNQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSESLKGREE 660
            KPGNVRNIIQHFENNQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSESLKGREE
Sbjct: 561  KPGNVRNIIQHFENNQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSESLKGREE 620

Query: 661  MKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRSI 720
            MKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRSI
Sbjct: 621  MKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRSI 680

Query: 721  ESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQEVIN 780
            ESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQEVIN
Sbjct: 681  ESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQEVIN 740

Query: 781  ELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLR 840
            ELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLR
Sbjct: 741  ELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLR 800

Query: 841  EEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEA 900
            EEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEA
Sbjct: 801  EEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEA 860

Query: 901  ESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYV 960
            ESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYV
Sbjct: 861  ESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYV 920

Query: 961  NEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDK 1020
            NEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDK
Sbjct: 921  NEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDK 980

Query: 1021 TLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDK 1080
            TLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDK
Sbjct: 981  TLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDK 1040

Query: 1081 RAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPR 1140
            RAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPR
Sbjct: 1041 RAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPR 1100

Query: 1141 EPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQGKHQVLLEDPEQEGSAEEEE 1200
            EPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQGKHQVLLEDPEQEGSAEEEE
Sbjct: 1101 EPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQGKHQVLLEDPEQEGSAEEEE 1160

Query: 1201 LGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADSALEDVENLRHLILWSLLPGH 1260
            LGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADSALEDVENLRHLILWSLLPGH
Sbjct: 1161 LGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADSALEDVENLRHLILWSLLPGH 1220

Query: 1261 TMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGGEGDNTQLAGLEGERPEQEDM 1320
            TMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGGEGDNTQLAGLEGERPEQEDM
Sbjct: 1221 TMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGGEGDNTQLAGLEGERPEQEDM 1280

Query: 1321 GLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGGYKVVRKAEVAGSKVVPALPES 1380
            GLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGGYKVVRKAEVAGSKVVPALPES
Sbjct: 1281 GLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGGYKVVRKAEVAGSKVVPALPES 1340

Query: 1381 GQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAPMSPPQPDSLPAGQTEPQPQL 1440
            GQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAPMSPPQPDSLPAGQTEPQPQL
Sbjct: 1341 GQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAPMSPPQPDSLPAGQTEPQPQL 1400

Query: 1441 QGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKLNRLKDMELAHRELLKSLGGESSGG 1500
            QGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKLNRLKDMELAHRELLKSLGGESSGG
Sbjct: 1401 QGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKLNRLKDMELAHRELLKSLGGESSGG 1460

Query: 1501 TTPVGSFHTEAARWTDGSLSPPAKEPLASDSRNSHELGPCPEDGSDAPLEDSTADAAASP 1560
            TTPVGSFHTEAARWTDGSLSPPAKEPLASDSRNSHELGPCPEDGSDAPLEDSTADAAASP
Sbjct: 1461 TTPVGSFHTEAARWTDGSLSPPAKEPLASDSRNSHELGPCPEDGSDAPLEDSTADAAASP 1520

Query: 1561 GP 1562
            GP
Sbjct: 1521 GP 1522


>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
            sapiens]
          Length = 1544

 Score =  695 bits (1793), Expect = 0.0
 Identities = 450/1184 (38%), Positives = 661/1184 (55%), Gaps = 89/1184 (7%)

Query: 7    QSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQKDQHGFGFTVSGDRI 66
            Q ++R++S       +  +K+ S   +    SE  GLVQRCVIIQKD +GFG TVSGD  
Sbjct: 34   QKVERIASHDFDPTDSSSKKTKSSSEE--SRSEIYGLVQRCVIIQKDDNGFGLTVSGDNP 91

Query: 67   VLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLLGSSPSS 126
            V VQSV+  GAAM+AGV+ GDRIIKVNGT+VT+S+HLEVVKLIKSG+YVALT+ G  P S
Sbjct: 92   VFVQSVKEDGAAMRAGVQTGDRIIKVNGTLVTHSNHLEVVKLIKSGSYVALTVQGRPPGS 151

Query: 127  MGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPPQRITGPKPLQDPE--VQKHATQILRN 184
              I     +  P+    ++ ++ SP  P      +RIT P  + +    V     +ILR 
Sbjct: 152  PQIPLADSEVEPSVIGHMSPIMTSPHSPGASGNMERITSPVLMGEENNVVHNQKVEILRK 211

Query: 185  MLRQEEKELQRICEVYSRNPASLLEEQIEGARRRVTQLQLKIQQETGGSVDILPLYGDTS 244
            ML++E++ LQ + E Y+R PA  L ++I+ A++ + QLQ ++ + TG + D   +   T 
Sbjct: 212  MLQKEQERLQLLQEDYNRTPAQRLLKEIQEAKKHIPQLQEQLSKATGSAQDGAVV---TP 268

Query: 245  QRPSEGRLSLDSQEGDSGLDSGTERFPSLSESLMNRNSVLSDPGLDSPRTSPVIMARVAQ 304
             RP    L++   E D G   G     S   S  + ++       DSP++ P    R+  
Sbjct: 269  SRPLGDTLTVSEAETDPGDVLGRTDCSSGDASRPSSDNA------DSPKSGP--KERIYL 320

Query: 305  HHRRQGSDAAVPSTGDQGVDQSPK----PLIIGPEEDYDPGYFNNESDII------FQDL 354
                + S+  +  T  Q +  SP     P IIG E+D     F  E + I      FQ +
Sbjct: 321  EENPEKSET-IQDTDTQSLVGSPSTRIAPHIIGAEDDD----FGTEHEQINGQCSCFQSI 375

Query: 355  EKLKSRPAHLGVFLRYIFSQADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAP 414
            E LKSRPAHL VFL ++ SQ DP+ LL YL +++Y+  + K++R +  +    FL+++A 
Sbjct: 376  ELLKSRPAHLAVFLHHVVSQFDPATLLCYLYSDLYKHTNSKETRRIFLEFHQFFLDRSAH 435

Query: 415  LRVKIPEMLQAEIDSR---LRNSEDARGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLY 471
            L+V +P+ + A+++ R   L   +  R  +   QE   PE+Q  + D+R KR++GL    
Sbjct: 436  LKVSVPDEMSADLEKRRPELIPEDLHRHYIQTMQERVHPEVQRHLEDFRQKRSMGLTLAE 495

Query: 472  GENDLLDLDGDPLR-----ERQVAEKQLAALGDIL---SKYEEDRSAPMDFALNTYMSHA 523
             E   LD + D  R     ER  AE+ +A + ++L      EED+S+ M + +  YM H 
Sbjct: 496  SELTKLDAERDKDRLTLEKERTCAEQIVAKIEEVLMTAQAVEEDKSSTMQYVILMYMKHL 555

Query: 524  GIRLREARPSNTAEKAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKP 583
            G++++E R         +   K   + F PK K+S   KK+K+  E  KR      +G P
Sbjct: 556  GVKVKEPR---------NLEHKRGRIGFLPKIKQSM--KKDKEGEEKGKRRGFPSILGPP 604

Query: 584  KSSSQSTFHIPLSPVEVK----------PGNVRNIIQHFENNQQYDAPEPGTQRLSTGSF 633
            +  S+         +E++          P +V    Q     +Q      GT     G  
Sbjct: 605  RRPSRHDNSAIGRAMELQKARHPKHLSTPSSVSPEPQDSAKLRQSGLANEGTD---AGYL 661

Query: 634  PEDLLESDSSRSEIRLGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSAS 693
            P +      S S +  G S S +G +E     K      +  D           +     
Sbjct: 662  PAN------SMSSVASGASFSQEGGKENDTGSKQVGETSAPGDTLDGTPRTLNTVFDFPP 715

Query: 694  SSTSSLSTRS--LENPTPPFTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEPEP 751
                 +      +E  T   TPK  R+     S+ F          E+DL        E 
Sbjct: 716  PPLDQVQEEECEVERVTEHGTPKPFRKF---DSVAFGESQSEDEQFENDL--------ET 764

Query: 752  DAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMP 811
            D  NWQ  V ++V+ GL   EI RQEVINELF TE +H+RTL+VLD +FYQR+ +E ++ 
Sbjct: 765  DPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILS 824

Query: 812  REELARLFPNLPELIEIHNSWCEAMKKLRE--EGPIIKEISDLMLARFDGPAREELQQVA 869
              EL ++F NL +++++H    E MK +R+  E  +I +I + +L  F GP  E+L+  A
Sbjct: 825  PSELRKIFSNLEDILQLHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAA 884

Query: 870  AQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLL 929
            A FCS Q  ALE+IK++Q+K+SRFQ F+Q+AES+P CRRLQL+D+I ++MQRLTKYPLLL
Sbjct: 885  ATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLL 944

Query: 930  ESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERAS 989
            ++I K+TE  T E EK+ +A D CR+IL YVN+AVK+ EN+ RLE YQ+RLD ++L+ + 
Sbjct: 945  DNIAKYTEWPT-EREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSE 1003

Query: 990  NPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHS 1049
             P   E ++LDLT RKMIHEGPL W++++DKT+DL+ LLLED+LVLLQKQD++L+L+CHS
Sbjct: 1004 YPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHS 1063

Query: 1050 KTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNT 1109
            K    ++DSK TFSPV+KL+ VL+R VATD +A F+I  S  G  QIYELVA T S+K  
Sbjct: 1064 KILASTADSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDNG-AQIYELVAQTVSEKTV 1122

Query: 1110 WMELLEEAVRNATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVE 1153
            W +L+   +  + +     P+P+    PG  +  ++ P+  + E
Sbjct: 1123 WQDLICR-MAASVKEQSTKPIPLPQSTPGEGDNDEEDPSKLKEE 1165


>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [Homo
            sapiens]
          Length = 927

 Score =  447 bits (1149), Expect = e-125
 Identities = 332/914 (36%), Positives = 487/914 (53%), Gaps = 105/914 (11%)

Query: 313  AAVPSTGDQGVDQSPKPLIIGPEEDYDPGYFNN--ESDIIFQDLEKLKSRPAHLGVFLRY 370
            AA P     G+   P  +I   +ED++     N  E +  FQ LE++K RPAHL   L++
Sbjct: 23   AASPGPSRPGL--VPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQH 80

Query: 371  IFSQADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIPEMLQAEIDSR 430
            +  Q +P PLL  L A++     PK+++    D ++ FLEK A LRV +P  +  E+D  
Sbjct: 81   VALQFEPGPLLCCLHADMLGSLGPKEAKKAFLDFYHSFLEKTAVLRVPVPPNVAFELDRT 140

Query: 431  LRN--SEDA-RGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLDG------ 481
              +  SED  R  + E  ++    +  Q+ D+R+KR +G+     E +L  L+       
Sbjct: 141  RADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPW--EQELAQLEAWVGRDR 198

Query: 482  --DPLRERQVAEKQLAALGDILSKY--EEDRSAPMDFALNTYMSHAGIRLREARPSNTAE 537
                 RER VAE+ L  L ++      +E++SA +  A+  YM H G+R +         
Sbjct: 199  ASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSG------- 251

Query: 538  KAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSP 597
                  DK     FF K K   N + ++ A   K  + IL      +   Q    +P   
Sbjct: 252  ------DKKSGRNFFRK-KVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQ----VP--- 297

Query: 598  VEVKPGNVRNIIQHFENNQQYDAPEPG-TQRLSTGSFPEDLLESDSSRSEIRLGRSESLK 656
                  + R++        + DA +PG T R      P        SR      R+    
Sbjct: 298  ------DFRHL------KAEVDAEKPGATDRKGGVGMP--------SRD-----RNIGAP 332

Query: 657  GREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMG 716
            G++    S      P S    D +  A+A  L    SS    +S  SL    PP +   G
Sbjct: 333  GQDTPGVSLH----PLSLDSPDREPGADAP-LELGDSSPQGPMSLESL---APPESTDEG 384

Query: 717  RRSIESPSLGFCTDTLLPHLLEDDLGQLS-DLEPEPDAQNWQHTVGKDVVAGLTQREIDR 775
              + ESP  G           E + G+   +LEPE +   W+  V  D +  L + ++ R
Sbjct: 385  AET-ESPEPGD----------EGEPGRSGLELEPE-EPPGWRELVPPDTLHSLPKSQVKR 432

Query: 776  QEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEA 835
            QEVI+EL VTEA+H+R LRVL  +F+Q M +    P EEL  +FP+L ELIE+H+ + + 
Sbjct: 433  QEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDR 492

Query: 836  MKKLREE-GPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQ 894
            + K R+E G +I+EI D++LARFDG      Q+++++FCS QS ALE +K KQRK+ RF 
Sbjct: 493  LMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFC 552

Query: 895  LFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCR 954
             F+QEAES P+CRRLQL+D+I +EMQRLTKYPLLL+SI ++TE  T E EK+  A + CR
Sbjct: 553  AFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPT-EREKVELAAECCR 611

Query: 955  EILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTW 1014
            EIL +VN+AV+  E+  RL+ YQ+RLD + L ++S+P+ +EFK+LD+T +K++HEGPLTW
Sbjct: 612  EILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTW 671

Query: 1015 RISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIR 1074
            R++KDK +++HVLLL+DLL+LLQ+QDE+LLLK HS+T   + D K    PVL+L + + R
Sbjct: 672  RVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTR 731

Query: 1075 SVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN-ATRHPGAAPMPVH 1133
             VATD +AF+++ T      QIYELVA T S++  W  L+ E   +     P + P P  
Sbjct: 732  EVATDHKAFYVLFTWD-QEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKP-R 789

Query: 1134 PPPPGPREP-----------AQQGPTPSRVELDDSDVF-HGEPEPEELPGGTGSQQRVQG 1181
            P P   REP            +  P  +R E   SD+     P PE     T + ++V  
Sbjct: 790  PSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAAT-ALRKVLS 848

Query: 1182 KHQVLLEDPEQEGS 1195
              Q+L    E  G+
Sbjct: 849  LKQLLFPAEEDNGA 862


>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [Homo
            sapiens]
          Length = 912

 Score =  447 bits (1149), Expect = e-125
 Identities = 332/914 (36%), Positives = 487/914 (53%), Gaps = 105/914 (11%)

Query: 313  AAVPSTGDQGVDQSPKPLIIGPEEDYDPGYFNN--ESDIIFQDLEKLKSRPAHLGVFLRY 370
            AA P     G+   P  +I   +ED++     N  E +  FQ LE++K RPAHL   L++
Sbjct: 8    AASPGPSRPGL--VPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQH 65

Query: 371  IFSQADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIPEMLQAEIDSR 430
            +  Q +P PLL  L A++     PK+++    D ++ FLEK A LRV +P  +  E+D  
Sbjct: 66   VALQFEPGPLLCCLHADMLGSLGPKEAKKAFLDFYHSFLEKTAVLRVPVPPNVAFELDRT 125

Query: 431  LRN--SEDA-RGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLDG------ 481
              +  SED  R  + E  ++    +  Q+ D+R+KR +G+     E +L  L+       
Sbjct: 126  RADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPW--EQELAQLEAWVGRDR 183

Query: 482  --DPLRERQVAEKQLAALGDILSKY--EEDRSAPMDFALNTYMSHAGIRLREARPSNTAE 537
                 RER VAE+ L  L ++      +E++SA +  A+  YM H G+R +         
Sbjct: 184  ASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSG------- 236

Query: 538  KAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSP 597
                  DK     FF K K   N + ++ A   K  + IL      +   Q    +P   
Sbjct: 237  ------DKKSGRNFFRK-KVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQ----VP--- 282

Query: 598  VEVKPGNVRNIIQHFENNQQYDAPEPG-TQRLSTGSFPEDLLESDSSRSEIRLGRSESLK 656
                  + R++        + DA +PG T R      P        SR      R+    
Sbjct: 283  ------DFRHL------KAEVDAEKPGATDRKGGVGMP--------SRD-----RNIGAP 317

Query: 657  GREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMG 716
            G++    S      P S    D +  A+A  L    SS    +S  SL    PP +   G
Sbjct: 318  GQDTPGVSLH----PLSLDSPDREPGADAP-LELGDSSPQGPMSLESL---APPESTDEG 369

Query: 717  RRSIESPSLGFCTDTLLPHLLEDDLGQLS-DLEPEPDAQNWQHTVGKDVVAGLTQREIDR 775
              + ESP  G           E + G+   +LEPE +   W+  V  D +  L + ++ R
Sbjct: 370  AET-ESPEPGD----------EGEPGRSGLELEPE-EPPGWRELVPPDTLHSLPKSQVKR 417

Query: 776  QEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEA 835
            QEVI+EL VTEA+H+R LRVL  +F+Q M +    P EEL  +FP+L ELIE+H+ + + 
Sbjct: 418  QEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDR 477

Query: 836  MKKLREE-GPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQ 894
            + K R+E G +I+EI D++LARFDG      Q+++++FCS QS ALE +K KQRK+ RF 
Sbjct: 478  LMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFC 537

Query: 895  LFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCR 954
             F+QEAES P+CRRLQL+D+I +EMQRLTKYPLLL+SI ++TE  T E EK+  A + CR
Sbjct: 538  AFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPT-EREKVELAAECCR 596

Query: 955  EILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTW 1014
            EIL +VN+AV+  E+  RL+ YQ+RLD + L ++S+P+ +EFK+LD+T +K++HEGPLTW
Sbjct: 597  EILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTW 656

Query: 1015 RISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIR 1074
            R++KDK +++HVLLL+DLL+LLQ+QDE+LLLK HS+T   + D K    PVL+L + + R
Sbjct: 657  RVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTR 716

Query: 1075 SVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN-ATRHPGAAPMPVH 1133
             VATD +AF+++ T      QIYELVA T S++  W  L+ E   +     P + P P  
Sbjct: 717  EVATDHKAFYVLFTWD-QEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKP-R 774

Query: 1134 PPPPGPREP-----------AQQGPTPSRVELDDSDVF-HGEPEPEELPGGTGSQQRVQG 1181
            P P   REP            +  P  +R E   SD+     P PE     T + ++V  
Sbjct: 775  PSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAAT-ALRKVLS 833

Query: 1182 KHQVLLEDPEQEGS 1195
              Q+L    E  G+
Sbjct: 834  LKQLLFPAEEDNGA 847


>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [Homo
            sapiens]
          Length = 879

 Score =  413 bits (1062), Expect = e-115
 Identities = 321/914 (35%), Positives = 470/914 (51%), Gaps = 138/914 (15%)

Query: 313  AAVPSTGDQGVDQSPKPLIIGPEEDYDPGYFNN--ESDIIFQDLEKLKSRPAHLGVFLRY 370
            AA P     G+   P  +I   +ED++     N  E +  FQ LE++K RPAHL   L++
Sbjct: 8    AASPGPSRPGL--VPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQH 65

Query: 371  IFSQADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIPEMLQAEIDSR 430
            +  Q +P PL+                                 LRV +P  +  E+D  
Sbjct: 66   VALQFEPGPLV---------------------------------LRVPVPPNVAFELDRT 92

Query: 431  LRN--SEDA-RGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLDG------ 481
              +  SED  R  + E  ++    +  Q+ D+R+KR +G+     E +L  L+       
Sbjct: 93   RADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPW--EQELAQLEAWVGRDR 150

Query: 482  --DPLRERQVAEKQLAALGDILSKY--EEDRSAPMDFALNTYMSHAGIRLREARPSNTAE 537
                 RER VAE+ L  L ++      +E++SA +  A+  YM H G+R +         
Sbjct: 151  ASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSG------- 203

Query: 538  KAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSP 597
                  DK     FF K K   N + ++ A   K  + IL      +   Q    +P   
Sbjct: 204  ------DKKSGRNFFRK-KVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQ----VP--- 249

Query: 598  VEVKPGNVRNIIQHFENNQQYDAPEPG-TQRLSTGSFPEDLLESDSSRSEIRLGRSESLK 656
                  + R++        + DA +PG T R      P        SR      R+    
Sbjct: 250  ------DFRHL------KAEVDAEKPGATDRKGGVGMP--------SRD-----RNIGAP 284

Query: 657  GREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMG 716
            G++    S      P S    D +  A+A  L    SS    +S  SL    PP +   G
Sbjct: 285  GQDTPGVSLH----PLSLDSPDREPGADAP-LELGDSSPQGPMSLESL---APPESTDEG 336

Query: 717  RRSIESPSLGFCTDTLLPHLLEDDLGQLS-DLEPEPDAQNWQHTVGKDVVAGLTQREIDR 775
              + ESP  G           E + G+   +LEPE +   W+  V  D +  L + ++ R
Sbjct: 337  AET-ESPEPGD----------EGEPGRSGLELEPE-EPPGWRELVPPDTLHSLPKSQVKR 384

Query: 776  QEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEA 835
            QEVI+EL VTEA+H+R LRVL  +F+Q M +    P EEL  +FP+L ELIE+H+ + + 
Sbjct: 385  QEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDR 444

Query: 836  MKKLREE-GPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQ 894
            + K R+E G +I+EI D++LARFDG      Q+++++FCS QS ALE +K KQRK+ RF 
Sbjct: 445  LMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFC 504

Query: 895  LFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCR 954
             F+QEAES P+CRRLQL+D+I +EMQRLTKYPLLL+SI ++TE  T E EK+  A + CR
Sbjct: 505  AFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPT-EREKVELAAECCR 563

Query: 955  EILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTW 1014
            EIL +VN+AV+  E+  RL+ YQ+RLD + L ++S+P+ +EFK+LD+T +K++HEGPLTW
Sbjct: 564  EILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTW 623

Query: 1015 RISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIR 1074
            R++KDK +++HVLLL+DLL+LLQ+QDE+LLLK HS+T   + D K    PVL+L + + R
Sbjct: 624  RVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTR 683

Query: 1075 SVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN-ATRHPGAAPMPVH 1133
             VATD +AF+++ T      QIYELVA T S++  W  L+ E   +     P + P P  
Sbjct: 684  EVATDHKAFYVLFTWD-QEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKP-R 741

Query: 1134 PPPPGPREP-----------AQQGPTPSRVELDDSDVF-HGEPEPEELPGGTGSQQRVQG 1181
            P P   REP            +  P  +R E   SD+     P PE     T + ++V  
Sbjct: 742  PSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAAT-ALRKVLS 800

Query: 1182 KHQVLLEDPEQEGS 1195
              Q+L    E  G+
Sbjct: 801  LKQLLFPAEEDNGA 814


>gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isoform b
            [Homo sapiens]
          Length = 1173

 Score =  190 bits (482), Expect = 1e-47
 Identities = 135/498 (27%), Positives = 246/498 (49%), Gaps = 50/498 (10%)

Query: 634  PEDLLESDSSRSEIR-LGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSA 692
            P   L SD S +  R +G + S KG  +   S             +MD A  A    +  
Sbjct: 141  PRGTLLSDGSPALSRNVGMTVSQKGGPQPTPSPAGPGTQLGPITGEMDEADSAFLKFKQT 200

Query: 693  SSSTSSLSTRSLEN--PTPPFTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEPE 750
            +  + SL++ + E+     P+T  + R  IES    F                       
Sbjct: 201  ADDSLSLTSPNTESIFVEDPYTASL-RSEIESDGHEF----------------------- 236

Query: 751  PDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLM 810
             +A++W   V         +  + RQ+V+ EL  TE  H+RTL+++  ++ + +++E   
Sbjct: 237  -EAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQF 295

Query: 811  PREELARLFPNLPELIEIHNSWCEAMKKLREEGP--------IIKEISDLMLARFDGPAR 862
              + + RLFP   +L+E H+ +   +K+ R+E          +I++I DL++ +F G   
Sbjct: 296  SSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENG 355

Query: 863  EELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRL 922
            E +++    FCS  + A+   K   ++  +FQ  +++  +    RRL +++ I+   QR+
Sbjct: 356  ERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRI 415

Query: 923  TKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDA 982
            TKYP+L+E II++TE GT ++E L +A +  ++I+  V+  V + E   RL     ++D 
Sbjct: 416  TKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDL 475

Query: 983  TALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEK 1042
             +  +  N L   F+  D+  R++  EG L W+ +  +  D+  +LL D+L+LLQ++D+K
Sbjct: 476  KSSSKLKNGLT--FRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQK 533

Query: 1043 LLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVAL 1102
             +          S DSK    PV+ L  +++R VA +++A F+I  S  G P++YE+   
Sbjct: 534  YVF--------ASVDSK---PPVISLQKLIVREVANEEKAMFLISASLQG-PEMYEIYTS 581

Query: 1103 TSSDKNTWMELLEEAVRN 1120
            +  D+N WM  ++ AV +
Sbjct: 582  SKEDRNAWMAHIQRAVES 599


>gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isoform a
            [Homo sapiens]
          Length = 1015

 Score =  189 bits (480), Expect = 2e-47
 Identities = 111/379 (29%), Positives = 208/379 (54%), Gaps = 22/379 (5%)

Query: 750  EPDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENL 809
            E +A++W   V         +  + RQ+V+ EL  TE  H+RTL+++  ++ + +++E  
Sbjct: 77   EFEAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQ 136

Query: 810  MPREELARLFPNLPELIEIHNSWCEAMKKLREEGP--------IIKEISDLMLARFDGPA 861
               + + RLFP   +L+E H+ +   +K+ R+E          +I++I DL++ +F G  
Sbjct: 137  FSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGEN 196

Query: 862  REELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQR 921
             E +++    FCS  + A+   K   ++  +FQ  +++  +    RRL +++ I+   QR
Sbjct: 197  GERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQR 256

Query: 922  LTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLD 981
            +TKYP+L+E II++TE GT ++E L +A +  ++I+  V+  V + E   RL     ++D
Sbjct: 257  ITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMD 316

Query: 982  ATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDE 1041
              +  +  N L   F+  D+  R++  EG L W+ +  +  D+  +LL D+L+LLQ++D+
Sbjct: 317  LKSSSKLKNGLT--FRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQ 374

Query: 1042 KLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVA 1101
            K +          S DSK    PV+ L  +++R VA +++A F+I  S  G P++YE+  
Sbjct: 375  KYVF--------ASVDSK---PPVISLQKLIVREVANEEKAMFLISASLQG-PEMYEIYT 422

Query: 1102 LTSSDKNTWMELLEEAVRN 1120
             +  D+N WM  ++ AV +
Sbjct: 423  SSKEDRNAWMAHIQRAVES 441


>gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isoform 2
            [Homo sapiens]
          Length = 985

 Score =  185 bits (470), Expect = 3e-46
 Identities = 128/453 (28%), Positives = 231/453 (50%), Gaps = 38/453 (8%)

Query: 686  TRLHQSASSSTSSLSTRSLENPTPPFTPKMGRR--SIESPSLGFCTDTLLPHLLEDDLGQ 743
            +R  +S+ S   S+ST ++       +P   RR  S  + SL     TL    L D+   
Sbjct: 137  SRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVI 196

Query: 744  LSDL-------EPEPDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVL 796
             S+L       E +  A +W   V    +    +  + +Q+VI EL  TE  H+RTL+++
Sbjct: 197  YSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIM 256

Query: 797  DLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGP--------IIKE 848
              +F   M +E  +    +  LFP + EL +IH  +   + + R +          +I  
Sbjct: 257  TRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHR 316

Query: 849  ISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRR 908
            + DL++++F GP+ E++ +  ++FCS  S AL+L K    ++ RFQ F+++       +R
Sbjct: 317  LGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKR 376

Query: 909  LQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTE 968
              +++ I+   QR+TKYPLL+  I++H+ G   E + L  A    +E+L  V+E + Q E
Sbjct: 377  HGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLE 436

Query: 969  NRHRLEGYQKRLDATALERASNPLAAE--FKSLDLTTRKMIHEGPLTWRISKDKTLDLHV 1026
               RL+    R+D     RA  P+  +  F   +L  RK+IH+G L W+ +  +  D+ V
Sbjct: 437  KGARLQEIYNRMD----PRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLV 492

Query: 1027 LLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFII 1086
            LL+ D+LV LQ++D+K +     K +            V+ L  +++R +A  ++  F+I
Sbjct: 493  LLMTDVLVFLQEKDQKYIFPTLDKPS------------VVSLQNLIVRDIANQEKGMFLI 540

Query: 1087 CTSKLGPPQIYELVALTSSDKNTWMELLEEAVR 1119
              +   PP++YE+   +  D++TW+ +++++VR
Sbjct: 541  SAA---PPEMYEVHTASRDDRSTWIRVIQQSVR 570


>gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isooform 3
            [Homo sapiens]
          Length = 958

 Score =  185 bits (470), Expect = 3e-46
 Identities = 128/453 (28%), Positives = 231/453 (50%), Gaps = 38/453 (8%)

Query: 686  TRLHQSASSSTSSLSTRSLENPTPPFTPKMGRR--SIESPSLGFCTDTLLPHLLEDDLGQ 743
            +R  +S+ S   S+ST ++       +P   RR  S  + SL     TL    L D+   
Sbjct: 110  SRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVI 169

Query: 744  LSDL-------EPEPDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVL 796
             S+L       E +  A +W   V    +    +  + +Q+VI EL  TE  H+RTL+++
Sbjct: 170  YSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIM 229

Query: 797  DLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGP--------IIKE 848
              +F   M +E  +    +  LFP + EL +IH  +   + + R +          +I  
Sbjct: 230  TRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHR 289

Query: 849  ISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRR 908
            + DL++++F GP+ E++ +  ++FCS  S AL+L K    ++ RFQ F+++       +R
Sbjct: 290  LGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKR 349

Query: 909  LQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTE 968
              +++ I+   QR+TKYPLL+  I++H+ G   E + L  A    +E+L  V+E + Q E
Sbjct: 350  HGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLE 409

Query: 969  NRHRLEGYQKRLDATALERASNPLAAE--FKSLDLTTRKMIHEGPLTWRISKDKTLDLHV 1026
               RL+    R+D     RA  P+  +  F   +L  RK+IH+G L W+ +  +  D+ V
Sbjct: 410  KGARLQEIYNRMD----PRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLV 465

Query: 1027 LLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFII 1086
            LL+ D+LV LQ++D+K +     K +            V+ L  +++R +A  ++  F+I
Sbjct: 466  LLMTDVLVFLQEKDQKYIFPTLDKPS------------VVSLQNLIVRDIANQEKGMFLI 513

Query: 1087 CTSKLGPPQIYELVALTSSDKNTWMELLEEAVR 1119
              +   PP++YE+   +  D++TW+ +++++VR
Sbjct: 514  SAA---PPEMYEVHTASRDDRSTWIRVIQQSVR 543


>gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isoform 1
            [Homo sapiens]
          Length = 986

 Score =  184 bits (468), Expect = 4e-46
 Identities = 128/454 (28%), Positives = 231/454 (50%), Gaps = 39/454 (8%)

Query: 686  TRLHQSASSSTSSLSTRSLENPTPPFTPKMGRR--SIESPSLGFCTDTLLPHLLEDDLGQ 743
            +R  +S+ S   S+ST ++       +P   RR  S  + SL     TL    L D+   
Sbjct: 137  SRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEAEV 196

Query: 744  L-----SDLEPEPD---AQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRV 795
            +     SD E +     A +W   V    +    +  + +Q+VI EL  TE  H+RTL++
Sbjct: 197  IYSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKI 256

Query: 796  LDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGP--------IIK 847
            +  +F   M +E  +    +  LFP + EL +IH  +   + + R +          +I 
Sbjct: 257  MTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIH 316

Query: 848  EISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCR 907
             + DL++++F GP+ E++ +  ++FCS  S AL+L K    ++ RFQ F+++       +
Sbjct: 317  RLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLK 376

Query: 908  RLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQT 967
            R  +++ I+   QR+TKYPLL+  I++H+ G   E + L  A    +E+L  V+E + Q 
Sbjct: 377  RHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQL 436

Query: 968  ENRHRLEGYQKRLDATALERASNPLAAE--FKSLDLTTRKMIHEGPLTWRISKDKTLDLH 1025
            E   RL+    R+D     RA  P+  +  F   +L  RK+IH+G L W+ +  +  D+ 
Sbjct: 437  EKGARLQEIYNRMD----PRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVL 492

Query: 1026 VLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFI 1085
            VLL+ D+LV LQ++D+K +     K +            V+ L  +++R +A  ++  F+
Sbjct: 493  VLLMTDVLVFLQEKDQKYIFPTLDKPS------------VVSLQNLIVRDIANQEKGMFL 540

Query: 1086 ICTSKLGPPQIYELVALTSSDKNTWMELLEEAVR 1119
            I  +   PP++YE+   +  D++TW+ +++++VR
Sbjct: 541  ISAA---PPEMYEVHTASRDDRSTWIRVIQQSVR 571


>gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]
          Length = 2817

 Score =  178 bits (451), Expect = 4e-44
 Identities = 183/805 (22%), Positives = 359/805 (44%), Gaps = 111/805 (13%)

Query: 555  TKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFEN 614
            +KKS   +KEKD +++K+++   K   K   +  +   IP+    V P +    ++ F N
Sbjct: 1763 SKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPV----VGPISCSQCMKPFTN 1818

Query: 615  NQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSE-SLKGREE------MKRSRKA 667
               Y           +    +   ES +S +++++ + + SL+  +       + R++ +
Sbjct: 1819 KDAYTCAN------CSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPS 1872

Query: 668  ENVPRSRSDVDM-DAAAE----ATRLHQSASSSTSSLSTRSL----ENPTPPFTPKMGRR 718
            +   R RS V + D  A     A R  Q + S + S+S +++     +     T K    
Sbjct: 1873 QPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSH 1932

Query: 719  SIES----PSLGFCTDTLLPHLLEDDLGQ---LSDLEPEP---DAQNWQHTVGKDVVAGL 768
            S +S      +   T++L    +  D+ +   L D E E    +A++W   +    +   
Sbjct: 1933 STDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQ 1992

Query: 769  TQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEI 828
             +  + RQEVI EL  TE  H+RTL+++  ++ Q M  + L  ++ + +LFP L ELI I
Sbjct: 1993 KKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISI 2052

Query: 829  HNSWCEAMKKLREEGPI--------IKEISDLMLARFDGPAREELQQVAAQFCSYQSIAL 880
            H+ + + + + ++E  +        IK I D+++ +F G   E L++   +FC   + ++
Sbjct: 2053 HSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSV 2112

Query: 881  ELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGT 940
               K    K+ RFQ F+++  S    RRL + + I+   QR+TKYP+L + I++ T+   
Sbjct: 2113 NYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNE 2172

Query: 941  SEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLD 1000
             E E L ++    ++++  V+  V   E + RL     + D+ ++ R  +     F   D
Sbjct: 2173 VEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKS--GQMFAKED 2230

Query: 1001 LTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQ 1060
            L  +K++ +G +  + +  +  ++  +LL D+LV LQ++D+K +          S D K 
Sbjct: 2231 LKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIF--------ASLDQKS 2282

Query: 1061 TFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN 1120
            T   V+ L  +++R VA +++  F+I +  +  P++ E+ A +  ++N+W++++++ +  
Sbjct: 2283 T---VISLKKLIVREVAHEEKGLFLI-SMGMTDPEMVEVHASSKEERNSWIQIIQDTINT 2338

Query: 1121 ATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQ 1180
              R                               D+ +    E E E+    T +++  +
Sbjct: 2339 LNR-------------------------------DEDEGIPSENEEEKKMLDTRARELKE 2367

Query: 1181 GKHQ----VLLEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEG 1236
              HQ    +LL   E+E    +      P P       +  +  R+    A  G   M+ 
Sbjct: 2368 QLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGGPLMK- 2426

Query: 1237 LADSALEDVENLRHLILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQA 1296
               SA+ +VE L+ L+  +L  G T+    +   E D+    S+            P +A
Sbjct: 2427 ---SAINEVEILQGLVSGNL--GGTLGPTVSSPIEQDVVGPVSL------------PRRA 2469

Query: 1297 PPGGEGDNTQLAGLEGERPEQEDMG 1321
               G  D+ Q+   +G   E+ D G
Sbjct: 2470 ETFGGFDSHQMNASKGGEKEEGDDG 2494


>gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]
          Length = 1058

 Score =  178 bits (451), Expect = 4e-44
 Identities = 183/805 (22%), Positives = 359/805 (44%), Gaps = 111/805 (13%)

Query: 555  TKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFEN 614
            +KKS   +KEKD +++K+++   K   K   +  +   IP+    V P +    ++ F N
Sbjct: 4    SKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPV----VGPISCSQCMKPFTN 59

Query: 615  NQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSE-SLKGREE------MKRSRKA 667
               Y           +    +   ES +S +++++ + + SL+  +       + R++ +
Sbjct: 60   KDAYTCAN------CSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPS 113

Query: 668  ENVPRSRSDVDM-DAAAE----ATRLHQSASSSTSSLSTRSL----ENPTPPFTPKMGRR 718
            +   R RS V + D  A     A R  Q + S + S+S +++     +     T K    
Sbjct: 114  QPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSH 173

Query: 719  SIES----PSLGFCTDTLLPHLLEDDLGQ---LSDLEPEP---DAQNWQHTVGKDVVAGL 768
            S +S      +   T++L    +  D+ +   L D E E    +A++W   +    +   
Sbjct: 174  STDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQ 233

Query: 769  TQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEI 828
             +  + RQEVI EL  TE  H+RTL+++  ++ Q M  + L  ++ + +LFP L ELI I
Sbjct: 234  KKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISI 293

Query: 829  HNSWCEAMKKLREEGPI--------IKEISDLMLARFDGPAREELQQVAAQFCSYQSIAL 880
            H+ + + + + ++E  +        IK I D+++ +F G   E L++   +FC   + ++
Sbjct: 294  HSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSV 353

Query: 881  ELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGT 940
               K    K+ RFQ F+++  S    RRL + + I+   QR+TKYP+L + I++ T+   
Sbjct: 354  NYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNE 413

Query: 941  SEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLD 1000
             E E L ++    ++++  V+  V   E + RL     + D+ ++ R  +     F   D
Sbjct: 414  VEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKS--GQMFAKED 471

Query: 1001 LTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQ 1060
            L  +K++ +G +  + +  +  ++  +LL D+LV LQ++D+K +          S D K 
Sbjct: 472  LKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIF--------ASLDQKS 523

Query: 1061 TFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN 1120
            T   V+ L  +++R VA +++  F+I +  +  P++ E+ A +  ++N+W++++++ +  
Sbjct: 524  T---VISLKKLIVREVAHEEKGLFLI-SMGMTDPEMVEVHASSKEERNSWIQIIQDTINT 579

Query: 1121 ATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQ 1180
              R                               D+ +    E E E+    T +++  +
Sbjct: 580  LNR-------------------------------DEDEGIPSENEEEKKMLDTRARELKE 608

Query: 1181 GKHQ----VLLEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEG 1236
              HQ    +LL   E+E    +      P P       +  +  R+    A  G   M+ 
Sbjct: 609  QLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGGPLMK- 667

Query: 1237 LADSALEDVENLRHLILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQA 1296
               SA+ +VE L+ L+  +L  G T+    +   E D+    S+            P +A
Sbjct: 668  ---SAINEVEILQGLVSGNL--GGTLGPTVSSPIEQDVVGPVSL------------PRRA 710

Query: 1297 PPGGEGDNTQLAGLEGERPEQEDMG 1321
               G  D+ Q+   +G   E+ D G
Sbjct: 711  ETFGGFDSHQMNASKGGEKEEGDDG 735


>gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]
          Length = 2813

 Score =  178 bits (451), Expect = 4e-44
 Identities = 183/805 (22%), Positives = 359/805 (44%), Gaps = 111/805 (13%)

Query: 555  TKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFEN 614
            +KKS   +KEKD +++K+++   K   K   +  +   IP+    V P +    ++ F N
Sbjct: 1759 SKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPV----VGPISCSQCMKPFTN 1814

Query: 615  NQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSE-SLKGREE------MKRSRKA 667
               Y           +    +   ES +S +++++ + + SL+  +       + R++ +
Sbjct: 1815 KDAYTCAN------CSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPS 1868

Query: 668  ENVPRSRSDVDM-DAAAE----ATRLHQSASSSTSSLSTRSL----ENPTPPFTPKMGRR 718
            +   R RS V + D  A     A R  Q + S + S+S +++     +     T K    
Sbjct: 1869 QPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSH 1928

Query: 719  SIES----PSLGFCTDTLLPHLLEDDLGQ---LSDLEPEP---DAQNWQHTVGKDVVAGL 768
            S +S      +   T++L    +  D+ +   L D E E    +A++W   +    +   
Sbjct: 1929 STDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQ 1988

Query: 769  TQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEI 828
             +  + RQEVI EL  TE  H+RTL+++  ++ Q M  + L  ++ + +LFP L ELI I
Sbjct: 1989 KKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISI 2048

Query: 829  HNSWCEAMKKLREEGPI--------IKEISDLMLARFDGPAREELQQVAAQFCSYQSIAL 880
            H+ + + + + ++E  +        IK I D+++ +F G   E L++   +FC   + ++
Sbjct: 2049 HSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSV 2108

Query: 881  ELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGT 940
               K    K+ RFQ F+++  S    RRL + + I+   QR+TKYP+L + I++ T+   
Sbjct: 2109 NYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNE 2168

Query: 941  SEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLD 1000
             E E L ++    ++++  V+  V   E + RL     + D+ ++ R  +     F   D
Sbjct: 2169 VEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKS--GQMFAKED 2226

Query: 1001 LTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQ 1060
            L  +K++ +G +  + +  +  ++  +LL D+LV LQ++D+K +          S D K 
Sbjct: 2227 LKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIF--------ASLDQKS 2278

Query: 1061 TFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN 1120
            T   V+ L  +++R VA +++  F+I +  +  P++ E+ A +  ++N+W++++++ +  
Sbjct: 2279 T---VISLKKLIVREVAHEEKGLFLI-SMGMTDPEMVEVHASSKEERNSWIQIIQDTINT 2334

Query: 1121 ATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQ 1180
              R                               D+ +    E E E+    T +++  +
Sbjct: 2335 LNR-------------------------------DEDEGIPSENEEEKKMLDTRARELKE 2363

Query: 1181 GKHQ----VLLEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEG 1236
              HQ    +LL   E+E    +      P P       +  +  R+    A  G   M+ 
Sbjct: 2364 QLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGGPLMK- 2422

Query: 1237 LADSALEDVENLRHLILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQA 1296
               SA+ +VE L+ L+  +L  G T+    +   E D+    S+            P +A
Sbjct: 2423 ---SAINEVEILQGLVSGNL--GGTLGPTVSSPIEQDVVGPVSL------------PRRA 2465

Query: 1297 PPGGEGDNTQLAGLEGERPEQEDMG 1321
               G  D+ Q+   +G   E+ D G
Sbjct: 2466 ETFGGFDSHQMNASKGGEKEEGDDG 2490


>gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens]
          Length = 1651

 Score =  169 bits (427), Expect = 3e-41
 Identities = 132/524 (25%), Positives = 247/524 (47%), Gaps = 57/524 (10%)

Query: 614  NNQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSESLKGREEMKRS---RKAENV 670
            N+   D P+PG     + S P  L            GR E++     + RS      E+ 
Sbjct: 718  NSSFRDIPQPGLSLHPSSSVPVGL----------PTGRRETVGQVHPLSRSVPGTTLESF 767

Query: 671  PRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRSIESPSL-GFCT 729
             RS + ++ ++   + R    +     S+ +                    SPS   F  
Sbjct: 768  RRSATSLESESDHNSCRSRSHSDELLQSMGS--------------------SPSTESFIM 807

Query: 730  DTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASH 789
            + ++   L  DL   SD + E +A++W   V         +  I RQ+VI EL  TE  H
Sbjct: 808  EDVVDSSLWSDLS--SDAQ-EFEAESWSLVVDPSFCNRQEKDVIKRQDVIFELMQTEMHH 864

Query: 790  LRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGP----- 844
            ++TL ++  IF + MK+E  +    + ++FP L EL+EIH  +  +MK+ R+E       
Sbjct: 865  IQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQESCAGSDR 924

Query: 845  --IIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAES 902
              +I  I D+++ +F      +++++  +FC +   A+ L K  Q+ + +FQ F++   S
Sbjct: 925  NFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKELQQNK-KFQNFIKLRNS 983

Query: 903  HPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNE 962
            +   RR  + + I+   QR+TKYP+L+E I+++T+  T EH+ L +A    ++++  V+ 
Sbjct: 984  NLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMIATVDL 1043

Query: 963  AVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTL 1022
             V + E   +      +++     +  N      ++L    R ++++G + W+ +  +  
Sbjct: 1044 KVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSEERTLLYDGLVYWKTATGRFK 1103

Query: 1023 DLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRA 1082
            D+  LLL D+L+ LQ++D+K +       AV    S      V+ L  ++ R VA ++R 
Sbjct: 1104 DILALLLTDVLLFLQEKDQKYIF-----AAVDQKPS------VISLQKLIAREVANEERG 1152

Query: 1083 FFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNATRHPG 1126
             F+I  S  G P++YE+   +  ++N WM  +++AV +     G
Sbjct: 1153 MFLISASSAG-PEMYEIHTNSKEERNNWMRRIQQAVESCPEEKG 1195


>gi|38373682 pleckstrin homology domain containing family G member 5
            isoform a [Homo sapiens]
          Length = 1006

 Score =  132 bits (331), Expect = 3e-30
 Identities = 116/427 (27%), Positives = 198/427 (46%), Gaps = 55/427 (12%)

Query: 768  LTQREIDRQEVINELFVTEASHLRTLRVLDLIFY---QRMKKENLMPREELARLFPNLPE 824
            LT+R+  +QE + EL  TEAS++R LRV+  +F      +++  L+   E  RLF N+PE
Sbjct: 330  LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPE 389

Query: 825  LIEIHNS-WCEAM----KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIA 879
            + ++H   W   M    +K R    +++    L   +  G     L +   ++C  +   
Sbjct: 390  IAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFG----SLFKPYIRYCMEEEGC 445

Query: 880  LELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGG 939
            +E ++   R    F+ ++  AE HPQC+RL+L D++    QRLTKYPLLL+S+++ TE  
Sbjct: 446  MEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEP 505

Query: 940  TSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERAS----NPLAAE 995
             ++ E +          + +VN  ++Q + R RL     R+DA  +  +S    + L  E
Sbjct: 506  RAK-EAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKE 564

Query: 996  FKSLDLT----------TRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLL 1045
            F  LDLT          TR+++ EG L  +  KD  +D++  L  DLL++ +        
Sbjct: 565  FLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTK-------- 616

Query: 1046 KCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKL-GPPQIYELVALTS 1104
                  AV  ++  +   P L ++ ++ R +  D  +F +I  ++       Y   A   
Sbjct: 617  ------AVKKAERTRVIRPPLLVDKIVCREL-RDPGSFLLIYLNEFHSAVGAYTFQASGQ 669

Query: 1105 SDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEP 1164
            +    W++ +  A +N  +   A        PPG ++P Q     S  E +D      E 
Sbjct: 670  ALCRGWVDTIYNA-QNQLQQLRA------QEPPGSQQPLQ-----SLEEEEDEQEEEEEE 717

Query: 1165 EPEELPG 1171
            E EE  G
Sbjct: 718  EEEEEEG 724


>gi|111154084 pleckstrin homology domain containing family G member 5
            isoform b [Homo sapiens]
          Length = 1083

 Score =  132 bits (331), Expect = 3e-30
 Identities = 116/427 (27%), Positives = 198/427 (46%), Gaps = 55/427 (12%)

Query: 768  LTQREIDRQEVINELFVTEASHLRTLRVLDLIFY---QRMKKENLMPREELARLFPNLPE 824
            LT+R+  +QE + EL  TEAS++R LRV+  +F      +++  L+   E  RLF N+PE
Sbjct: 407  LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPE 466

Query: 825  LIEIHNS-WCEAM----KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIA 879
            + ++H   W   M    +K R    +++    L   +  G     L +   ++C  +   
Sbjct: 467  IAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFG----SLFKPYIRYCMEEEGC 522

Query: 880  LELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGG 939
            +E ++   R    F+ ++  AE HPQC+RL+L D++    QRLTKYPLLL+S+++ TE  
Sbjct: 523  MEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEP 582

Query: 940  TSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERAS----NPLAAE 995
             ++ E +          + +VN  ++Q + R RL     R+DA  +  +S    + L  E
Sbjct: 583  RAK-EAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKE 641

Query: 996  FKSLDLT----------TRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLL 1045
            F  LDLT          TR+++ EG L  +  KD  +D++  L  DLL++ +        
Sbjct: 642  FLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTK-------- 693

Query: 1046 KCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKL-GPPQIYELVALTS 1104
                  AV  ++  +   P L ++ ++ R +  D  +F +I  ++       Y   A   
Sbjct: 694  ------AVKKAERTRVIRPPLLVDKIVCREL-RDPGSFLLIYLNEFHSAVGAYTFQASGQ 746

Query: 1105 SDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEP 1164
            +    W++ +  A +N  +   A        PPG ++P Q     S  E +D      E 
Sbjct: 747  ALCRGWVDTIYNA-QNQLQQLRA------QEPPGSQQPLQ-----SLEEEEDEQEEEEEE 794

Query: 1165 EPEELPG 1171
            E EE  G
Sbjct: 795  EEEEEEG 801


>gi|111154088 pleckstrin homology domain containing family G member 5
            isoform a [Homo sapiens]
          Length = 1006

 Score =  132 bits (331), Expect = 3e-30
 Identities = 116/427 (27%), Positives = 198/427 (46%), Gaps = 55/427 (12%)

Query: 768  LTQREIDRQEVINELFVTEASHLRTLRVLDLIFY---QRMKKENLMPREELARLFPNLPE 824
            LT+R+  +QE + EL  TEAS++R LRV+  +F      +++  L+   E  RLF N+PE
Sbjct: 330  LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPE 389

Query: 825  LIEIHNS-WCEAM----KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIA 879
            + ++H   W   M    +K R    +++    L   +  G     L +   ++C  +   
Sbjct: 390  IAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFG----SLFKPYIRYCMEEEGC 445

Query: 880  LELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGG 939
            +E ++   R    F+ ++  AE HPQC+RL+L D++    QRLTKYPLLL+S+++ TE  
Sbjct: 446  MEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEP 505

Query: 940  TSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERAS----NPLAAE 995
             ++ E +          + +VN  ++Q + R RL     R+DA  +  +S    + L  E
Sbjct: 506  RAK-EAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKE 564

Query: 996  FKSLDLT----------TRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLL 1045
            F  LDLT          TR+++ EG L  +  KD  +D++  L  DLL++ +        
Sbjct: 565  FLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTK-------- 616

Query: 1046 KCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKL-GPPQIYELVALTS 1104
                  AV  ++  +   P L ++ ++ R +  D  +F +I  ++       Y   A   
Sbjct: 617  ------AVKKAERTRVIRPPLLVDKIVCREL-RDPGSFLLIYLNEFHSAVGAYTFQASGQ 669

Query: 1105 SDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEP 1164
            +    W++ +  A +N  +   A        PPG ++P Q     S  E +D      E 
Sbjct: 670  ALCRGWVDTIYNA-QNQLQQLRA------QEPPGSQQPLQ-----SLEEEEDEQEEEEEE 717

Query: 1165 EPEELPG 1171
            E EE  G
Sbjct: 718  EEEEEEG 724


>gi|111154080 pleckstrin homology domain containing family G member 5
            isoform a [Homo sapiens]
          Length = 1006

 Score =  132 bits (331), Expect = 3e-30
 Identities = 116/427 (27%), Positives = 198/427 (46%), Gaps = 55/427 (12%)

Query: 768  LTQREIDRQEVINELFVTEASHLRTLRVLDLIFY---QRMKKENLMPREELARLFPNLPE 824
            LT+R+  +QE + EL  TEAS++R LRV+  +F      +++  L+   E  RLF N+PE
Sbjct: 330  LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPE 389

Query: 825  LIEIHNS-WCEAM----KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIA 879
            + ++H   W   M    +K R    +++    L   +  G     L +   ++C  +   
Sbjct: 390  IAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFG----SLFKPYIRYCMEEEGC 445

Query: 880  LELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGG 939
            +E ++   R    F+ ++  AE HPQC+RL+L D++    QRLTKYPLLL+S+++ TE  
Sbjct: 446  MEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEP 505

Query: 940  TSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERAS----NPLAAE 995
             ++ E +          + +VN  ++Q + R RL     R+DA  +  +S    + L  E
Sbjct: 506  RAK-EAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKE 564

Query: 996  FKSLDLT----------TRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLL 1045
            F  LDLT          TR+++ EG L  +  KD  +D++  L  DLL++ +        
Sbjct: 565  FLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTK-------- 616

Query: 1046 KCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKL-GPPQIYELVALTS 1104
                  AV  ++  +   P L ++ ++ R +  D  +F +I  ++       Y   A   
Sbjct: 617  ------AVKKAERTRVIRPPLLVDKIVCREL-RDPGSFLLIYLNEFHSAVGAYTFQASGQ 669

Query: 1105 SDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEP 1164
            +    W++ +  A +N  +   A        PPG ++P Q     S  E +D      E 
Sbjct: 670  ALCRGWVDTIYNA-QNQLQQLRA------QEPPGSQQPLQ-----SLEEEEDEQEEEEEE 717

Query: 1165 EPEELPG 1171
            E EE  G
Sbjct: 718  EEEEEEG 724


>gi|111154078 pleckstrin homology domain containing family G member 5
            isoform c [Homo sapiens]
          Length = 1062

 Score =  132 bits (331), Expect = 3e-30
 Identities = 116/427 (27%), Positives = 198/427 (46%), Gaps = 55/427 (12%)

Query: 768  LTQREIDRQEVINELFVTEASHLRTLRVLDLIFY---QRMKKENLMPREELARLFPNLPE 824
            LT+R+  +QE + EL  TEAS++R LRV+  +F      +++  L+   E  RLF N+PE
Sbjct: 386  LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPE 445

Query: 825  LIEIHNS-WCEAM----KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIA 879
            + ++H   W   M    +K R    +++    L   +  G     L +   ++C  +   
Sbjct: 446  IAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFG----SLFKPYIRYCMEEEGC 501

Query: 880  LELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGG 939
            +E ++   R    F+ ++  AE HPQC+RL+L D++    QRLTKYPLLL+S+++ TE  
Sbjct: 502  MEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEP 561

Query: 940  TSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERAS----NPLAAE 995
             ++ E +          + +VN  ++Q + R RL     R+DA  +  +S    + L  E
Sbjct: 562  RAK-EAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKE 620

Query: 996  FKSLDLT----------TRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLL 1045
            F  LDLT          TR+++ EG L  +  KD  +D++  L  DLL++ +        
Sbjct: 621  FLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTK-------- 672

Query: 1046 KCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKL-GPPQIYELVALTS 1104
                  AV  ++  +   P L ++ ++ R +  D  +F +I  ++       Y   A   
Sbjct: 673  ------AVKKAERTRVIRPPLLVDKIVCREL-RDPGSFLLIYLNEFHSAVGAYTFQASGQ 725

Query: 1105 SDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEP 1164
            +    W++ +  A +N  +   A        PPG ++P Q     S  E +D      E 
Sbjct: 726  ALCRGWVDTIYNA-QNQLQQLRA------QEPPGSQQPLQ-----SLEEEEDEQEEEEEE 773

Query: 1165 EPEELPG 1171
            E EE  G
Sbjct: 774  EEEEEEG 780


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score =  122 bits (306), Expect = 3e-27
 Identities = 97/362 (26%), Positives = 170/362 (46%), Gaps = 35/362 (9%)

Query: 768  LTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIE 827
            LT  E  RQ  I+EL VTE +++  L+++  IF + + +  L+  +E+A +F N  ELI 
Sbjct: 1231 LTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIM 1290

Query: 828  IHNSWCEAM---KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIK 884
             +    +A+   KK+  E   +K I D++ A+          Q   +FCS Q     LI+
Sbjct: 1291 CNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPH------MQPYIRFCSRQLNGAALIQ 1344

Query: 885  TKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHE 944
             K  +   F+ F++     P+C+ + L   I+  MQR+T+YPL++++I+++T     +H 
Sbjct: 1345 QKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHS 1404

Query: 945  KLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTR 1004
             L  A ++  E+   VNE V++ EN  RLE  Q  +    L   S  L     +  L  R
Sbjct: 1405 HLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGL---SEQLVFNSVTNCLGPR 1461

Query: 1005 KMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSP 1064
            K +H G L ++   +K  +L+  L  D L+L Q               +GSS + + FSP
Sbjct: 1462 KFLHSGKL-YKAKSNK--ELYGFLFNDFLLLTQ-----------ITKPLGSSGTDKVFSP 1507

Query: 1065 VLKLNAVLIRSVATDKRAFFIICTSKLGP---------PQIYELVALTSSDKNTWMELLE 1115
               L   + ++          + T   G           ++Y L A + +++  W++ ++
Sbjct: 1508 KSNLQYKMYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAWVQKIK 1567

Query: 1116 EA 1117
             A
Sbjct: 1568 AA 1569


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score =  120 bits (301), Expect = 1e-26
 Identities = 92/353 (26%), Positives = 171/353 (48%), Gaps = 24/353 (6%)

Query: 772  EIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNS 831
            E  RQ  I+EL  TE  ++  L+++  +F +RM +   +   E+A +F N  ELI  +  
Sbjct: 1180 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1239

Query: 832  WCEAM---KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQR 888
              +A+   KK   E   ++ I D++ A           Q   +FCS Q     L++ K  
Sbjct: 1240 LLKALRVRKKTGGEKMPVQMIGDILAAELSH------MQAYIRFCSCQLNGAALLQQKTD 1293

Query: 889  KESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCR 948
            +++ F+ F+++  S P+C+ + L   ++  MQR+T+YPLL+ SI+++T    ++H  L  
Sbjct: 1294 EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL 1353

Query: 949  ARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIH 1008
            A ++  E+   VNE V++ EN  RLE  Q  +    L   +  L     +  L  RK++H
Sbjct: 1354 ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGL---AEQLIFNSLTNCLGPRKLLH 1410

Query: 1009 EGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSK-QTFSPVLK 1067
             G L ++   +K  +LH  L  D L+L     +  +     K     S+++ + +   + 
Sbjct: 1411 SGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIF 1467

Query: 1068 LNAVLIR---SVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEA 1117
            LN VL++     ++D+  F I    +     +Y L     +++  W++ ++ A
Sbjct: 1468 LNEVLVKLPTDPSSDEPVFHISHIDR-----VYTLRTDNINERTAWVQKIKAA 1515


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score =  120 bits (301), Expect = 1e-26
 Identities = 92/353 (26%), Positives = 171/353 (48%), Gaps = 24/353 (6%)

Query: 772  EIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNS 831
            E  RQ  I+EL  TE  ++  L+++  +F +RM +   +   E+A +F N  ELI  +  
Sbjct: 1207 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1266

Query: 832  WCEAM---KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQR 888
              +A+   KK   E   ++ I D++ A           Q   +FCS Q     L++ K  
Sbjct: 1267 LLKALRVRKKTGGEKMPVQMIGDILAAELSH------MQAYIRFCSCQLNGAALLQQKTD 1320

Query: 889  KESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCR 948
            +++ F+ F+++  S P+C+ + L   ++  MQR+T+YPLL+ SI+++T    ++H  L  
Sbjct: 1321 EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL 1380

Query: 949  ARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIH 1008
            A ++  E+   VNE V++ EN  RLE  Q  +    L   +  L     +  L  RK++H
Sbjct: 1381 ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGL---AEQLIFNSLTNCLGPRKLLH 1437

Query: 1009 EGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSK-QTFSPVLK 1067
             G L ++   +K  +LH  L  D L+L     +  +     K     S+++ + +   + 
Sbjct: 1438 SGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIF 1494

Query: 1068 LNAVLIR---SVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEA 1117
            LN VL++     ++D+  F I    +     +Y L     +++  W++ ++ A
Sbjct: 1495 LNEVLVKLPTDPSSDEPVFHISHIDR-----VYTLRTDNINERTAWVQKIKAA 1542


>gi|222080070 pleckstrin homology domain-containing family G member 6
            isoform b [Homo sapiens]
          Length = 758

 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 113/464 (24%), Positives = 195/464 (42%), Gaps = 58/464 (12%)

Query: 693  SSSTSSLSTRSLENPTPP--FTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLE-- 748
            S     LS   L +P P       +G   + SP L   T     H LE  L   S     
Sbjct: 31   SGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKA---HELEVRLHTFSMFGMP 87

Query: 749  --PEPDAQNWQHTVGKD-----------VVAG---LTQREIDRQEVINELFVTEASHLRT 792
              P  D ++W+   G D           +V G   ++Q    +QE + EL  TE  ++R 
Sbjct: 88   RLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRK 147

Query: 793  LRVL-DLIF--YQRMKKENLMPREELARLFPNLPELIEIHNS-WCEAMKKLREEGPIIKE 848
            L+++ DL+      +++  L+       LF N+P LI  H S W E +    EE     +
Sbjct: 148  LKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQ 207

Query: 849  ISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRR 908
              D +  +       +      Q+C      +   + +Q     F  F+Q  E H +  R
Sbjct: 208  PLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGR 267

Query: 909  LQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTE 968
              L DL+I   QR+TKYPLLL +++K +    ++ E L    +     L+++N  V+Q E
Sbjct: 268  QMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQ-EALNAMIEAVESFLRHINGQVRQGE 326

Query: 969  NRHRLEGYQKRLDA-TALERASNPLAAE---FKSLDLT----------TRKMIHEGPLTW 1014
             +  L    +R+     LE  S+ +      F +LDLT          TR+++ EGP+  
Sbjct: 327  EQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRV 386

Query: 1015 RISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIR 1074
            +  ++  LD+++ L  D+L++ + Q +              +D  +   P L L  ++ +
Sbjct: 387  KEGREGKLDVYLFLFSDVLLVTKPQRK--------------ADKAKVIRPPLMLEKLVCQ 432

Query: 1075 SVATDKRAFFIICTSKLGPPQIYELVALTS-SDKNTWMELLEEA 1117
             +  D  +F +I  ++        LV   S +D+  W+E  ++A
Sbjct: 433  PL-RDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQA 475


>gi|222080068 pleckstrin homology domain-containing family G member 6
            isoform a [Homo sapiens]
          Length = 790

 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 113/464 (24%), Positives = 195/464 (42%), Gaps = 58/464 (12%)

Query: 693  SSSTSSLSTRSLENPTPP--FTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLE-- 748
            S     LS   L +P P       +G   + SP L   T     H LE  L   S     
Sbjct: 63   SGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKA---HELEVRLHTFSMFGMP 119

Query: 749  --PEPDAQNWQHTVGKD-----------VVAG---LTQREIDRQEVINELFVTEASHLRT 792
              P  D ++W+   G D           +V G   ++Q    +QE + EL  TE  ++R 
Sbjct: 120  RLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRK 179

Query: 793  LRVL-DLIF--YQRMKKENLMPREELARLFPNLPELIEIHNS-WCEAMKKLREEGPIIKE 848
            L+++ DL+      +++  L+       LF N+P LI  H S W E +    EE     +
Sbjct: 180  LKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQ 239

Query: 849  ISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRR 908
              D +  +       +      Q+C      +   + +Q     F  F+Q  E H +  R
Sbjct: 240  PLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGR 299

Query: 909  LQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTE 968
              L DL+I   QR+TKYPLLL +++K +    ++ E L    +     L+++N  V+Q E
Sbjct: 300  QMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQ-EALNAMIEAVESFLRHINGQVRQGE 358

Query: 969  NRHRLEGYQKRLDA-TALERASNPLAAE---FKSLDLT----------TRKMIHEGPLTW 1014
             +  L    +R+     LE  S+ +      F +LDLT          TR+++ EGP+  
Sbjct: 359  EQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRV 418

Query: 1015 RISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIR 1074
            +  ++  LD+++ L  D+L++ + Q +              +D  +   P L L  ++ +
Sbjct: 419  KEGREGKLDVYLFLFSDVLLVTKPQRK--------------ADKAKVIRPPLMLEKLVCQ 464

Query: 1075 SVATDKRAFFIICTSKLGPPQIYELVALTS-SDKNTWMELLEEA 1117
             +  D  +F +I  ++        LV   S +D+  W+E  ++A
Sbjct: 465  PL-RDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQA 507


>gi|222080066 pleckstrin homology domain-containing family G member 6
            isoform a [Homo sapiens]
          Length = 790

 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 113/464 (24%), Positives = 195/464 (42%), Gaps = 58/464 (12%)

Query: 693  SSSTSSLSTRSLENPTPP--FTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLE-- 748
            S     LS   L +P P       +G   + SP L   T     H LE  L   S     
Sbjct: 63   SGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKA---HELEVRLHTFSMFGMP 119

Query: 749  --PEPDAQNWQHTVGKD-----------VVAG---LTQREIDRQEVINELFVTEASHLRT 792
              P  D ++W+   G D           +V G   ++Q    +QE + EL  TE  ++R 
Sbjct: 120  RLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRK 179

Query: 793  LRVL-DLIF--YQRMKKENLMPREELARLFPNLPELIEIHNS-WCEAMKKLREEGPIIKE 848
            L+++ DL+      +++  L+       LF N+P LI  H S W E +    EE     +
Sbjct: 180  LKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQ 239

Query: 849  ISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRR 908
              D +  +       +      Q+C      +   + +Q     F  F+Q  E H +  R
Sbjct: 240  PLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGR 299

Query: 909  LQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTE 968
              L DL+I   QR+TKYPLLL +++K +    ++ E L    +     L+++N  V+Q E
Sbjct: 300  QMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQ-EALNAMIEAVESFLRHINGQVRQGE 358

Query: 969  NRHRLEGYQKRLDA-TALERASNPLAAE---FKSLDLT----------TRKMIHEGPLTW 1014
             +  L    +R+     LE  S+ +      F +LDLT          TR+++ EGP+  
Sbjct: 359  EQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRV 418

Query: 1015 RISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIR 1074
            +  ++  LD+++ L  D+L++ + Q +              +D  +   P L L  ++ +
Sbjct: 419  KEGREGKLDVYLFLFSDVLLVTKPQRK--------------ADKAKVIRPPLMLEKLVCQ 464

Query: 1075 SVATDKRAFFIICTSKLGPPQIYELVALTS-SDKNTWMELLEEA 1117
             +  D  +F +I  ++        LV   S +D+  W+E  ++A
Sbjct: 465  PL-RDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQA 507


>gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 [Homo
            sapiens]
          Length = 532

 Score = 90.9 bits (224), Expect = 9e-18
 Identities = 120/520 (23%), Positives = 214/520 (41%), Gaps = 65/520 (12%)

Query: 654  SLKGREEMKRSRKAEN-----VPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPT 708
            S  G+ E++R+R+  N     + R  S  ++    +AT L + + +   S+S RS   P 
Sbjct: 27   STTGQMELRRTREPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRP- 85

Query: 709  PPFTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGL 768
                                 D L P     +    S      D++ W  T    V   L
Sbjct: 86   ---------------------DILAPRPWSRNAAPSST--KRRDSKLWSETFDVCVNQML 122

Query: 769  TQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEI 828
            T +EI RQE I EL   E   +  L++    ++  M K ++M  +EL ++F  L  LI +
Sbjct: 123  TSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPL 182

Query: 829  HNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQR 888
            H      ++ +R+     + +  +++      +  +       +CS Q  A  L+  K +
Sbjct: 183  HEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYD------SYCSNQVAAKALLDHK-K 235

Query: 889  KESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCR 948
            ++ R Q F+Q     P  R+L L + +     RL KYPLLL  I++HT     + + L  
Sbjct: 236  QDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEE 295

Query: 949  ARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIH 1008
            A +  + I+  +N    ++E R+    Y++RL    LE           SL  ++R +  
Sbjct: 296  AINIIQGIVAEINTKTGESECRY----YKERL--LYLEEGQK------DSLIDSSRVLCC 343

Query: 1009 EGPLTWRISKDKTLDLHVLLLEDLLVLLQ--KQDEKLLLKCHSK-TAVGSSDSKQTFSPV 1065
             G L      ++ + LHV L +++LV+ +    +E+L  + + +   V     +      
Sbjct: 344  HGEL----KNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGE 399

Query: 1066 LKLNAVLIRSVATDKRA--FFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNATR 1123
            ++L   L  + + ++R   FF +        Q + L A  + +K  W+  + +A      
Sbjct: 400  VRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLC 459

Query: 1124 HPGAAPM-----PVHPPPPGPREPAQQGPTPSRVELDDSD 1158
              G A +         P  G RE   QG T    ++D SD
Sbjct: 460  AAGQAGVLDSEGSFLNPTTGSRE--LQGETKLE-QMDQSD 496


>gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 [Homo
            sapiens]
          Length = 558

 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 100/417 (23%), Positives = 180/417 (43%), Gaps = 36/417 (8%)

Query: 752  DAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMP 811
            D++ W  T    V   LT +EI RQE I EL   E   +  L++    ++  M K ++M 
Sbjct: 132  DSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMT 191

Query: 812  REELARLFPNLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQ 871
             +EL ++F  L  LI +H      ++ +R+     + +  +++      +  +       
Sbjct: 192  EQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYD------S 245

Query: 872  FCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLES 931
            +CS Q  A  L+  K +++ R Q F+Q     P  R+L L + +     RL KYPLLL  
Sbjct: 246  YCSNQVAAKALLDHK-KQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLRE 304

Query: 932  IIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNP 991
            I++HT     + + L  A +  + I+  +N    ++E R+    Y++RL    LE     
Sbjct: 305  ILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRY----YKERL--LYLEEGQK- 357

Query: 992  LAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQ--KQDEKLLLKCHS 1049
                  SL  ++R +   G L      ++ + LHV L +++LV+ +    +E+L  + + 
Sbjct: 358  -----DSLIDSSRVLCCHGEL----KNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYR 408

Query: 1050 K-TAVGSSDSKQTFSPVLKLNAVLIRSVATDKRA--FFIICTSKLGPPQIYELVALTSSD 1106
            +   V     +      ++L   L  + + ++R   FF +        Q + L A  + +
Sbjct: 409  QPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFN 468

Query: 1107 KNTWMELLEEAVRNATRHPGAAPM-----PVHPPPPGPREPAQQGPTPSRVELDDSD 1158
            K  W+  + +A        G A +         P  G RE   QG T    ++D SD
Sbjct: 469  KQQWLNCIRQAKETVLCAAGQAGVLDSEGSFLNPTTGSRE--LQGETKLE-QMDQSD 522


>gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [Homo
            sapiens]
          Length = 526

 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 100/417 (23%), Positives = 180/417 (43%), Gaps = 36/417 (8%)

Query: 752  DAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMP 811
            D++ W  T    V   LT +EI RQE I EL   E   +  L++    ++  M K ++M 
Sbjct: 100  DSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMT 159

Query: 812  REELARLFPNLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQ 871
             +EL ++F  L  LI +H      ++ +R+     + +  +++      +  +       
Sbjct: 160  EQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYD------S 213

Query: 872  FCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLES 931
            +CS Q  A  L+  K +++ R Q F+Q     P  R+L L + +     RL KYPLLL  
Sbjct: 214  YCSNQVAAKALLDHK-KQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLRE 272

Query: 932  IIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNP 991
            I++HT     + + L  A +  + I+  +N    ++E R+    Y++RL    LE     
Sbjct: 273  ILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRY----YKERL--LYLEEGQK- 325

Query: 992  LAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQ--KQDEKLLLKCHS 1049
                  SL  ++R +   G L      ++ + LHV L +++LV+ +    +E+L  + + 
Sbjct: 326  -----DSLIDSSRVLCCHGEL----KNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYR 376

Query: 1050 K-TAVGSSDSKQTFSPVLKLNAVLIRSVATDKRA--FFIICTSKLGPPQIYELVALTSSD 1106
            +   V     +      ++L   L  + + ++R   FF +        Q + L A  + +
Sbjct: 377  QPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFN 436

Query: 1107 KNTWMELLEEAVRNATRHPGAAPM-----PVHPPPPGPREPAQQGPTPSRVELDDSD 1158
            K  W+  + +A        G A +         P  G RE   QG T    ++D SD
Sbjct: 437  KQQWLNCIRQAKETVLCAAGQAGVLDSEGSFLNPTTGSRE--LQGETKLE-QMDQSD 490


>gi|21735572 epithelial cell transforming sequence 2 oncogene protein
            [Homo sapiens]
          Length = 883

 Score = 85.5 bits (210), Expect = 4e-16
 Identities = 99/470 (21%), Positives = 197/470 (41%), Gaps = 43/470 (9%)

Query: 677  VDMDA-AAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRSIESPSLGFCTDTL--- 732
            + MDA A E   L++ A++     S   L   TP    K  R       L   TD     
Sbjct: 310  IQMDARAGETMYLYEKANTPELKKSVSMLSLNTPNSNRKRRRLKETLAQLSRETDVSPFP 369

Query: 733  ------LPHLLEDDLGQLSDLEPEPDAQ-NWQHTVGKDVVAG-----LTQREIDRQEVIN 780
                    H L   +G L D+   P++  N+  T      +      +  ++  R +V  
Sbjct: 370  PRKRPSAEHSLS--IGSLLDISNTPESSINYGDTPKSCTKSSKSSTPVPSKQSARWQVAK 427

Query: 781  ELFVTEASHLRTLRVLDLIFYQRMKKEN-----LMPREELARLFPNLPELIEIHNSWCEA 835
            EL+ TE++++  L  +  +F   +++E      ++  EE+  +F ++P++ ++H    + 
Sbjct: 428  ELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVHTKIKDD 487

Query: 836  MKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQL 895
            ++ L       K I D+ L        ++L +    F ++  ++ E I   ++++ RF  
Sbjct: 488  LEDLIVNWDESKSIGDIFLKY-----SKDLVKTYPPFVNFFEMSKETIIKCEKQKPRFHA 542

Query: 896  FMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCRE 955
            F++  ++ P+C R  L +L+I  +QRL    LLL  + KHT     +   L +A    +E
Sbjct: 543  FLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGSLKE 602

Query: 956  ILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTWR 1015
            ++ ++NE  ++TE + ++      +D       +N L++    +       + E P    
Sbjct: 603  VMTHINEDKRKTEAQKQIFDVVYEVDGC----PANLLSSHRSLVQRVETISLGEHPC--- 655

Query: 1016 ISKDKTLDLHVLLLEDLLVLLQKQDEKL--LLKCHSKTAVGSSDSKQTFSPVLKLNAVL- 1072
               D+   + + L  D L + +K+ + +      H +T   +S       P+ ++  VL 
Sbjct: 656  ---DRGEQVTLFLFNDCLEIARKRHKVIGTFRSPHGQTRPPASLKHIHLMPLSQIKKVLD 712

Query: 1073 IRSVATDKRAFFIICTSKLGPPQIYELVALTSSD--KNTWMELLEEAVRN 1120
            IR       AF ++         +     +TS +  K  W+++L   V N
Sbjct: 713  IRETEDCHNAFALLVRPPTEQANVLLSFQMTSDELPKENWLKMLCRHVAN 762


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.131    0.377 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 71,622,295
Number of Sequences: 37866
Number of extensions: 4164070
Number of successful extensions: 37612
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 364
Number of HSP's successfully gapped in prelim test: 659
Number of HSP's that attempted gapping in prelim test: 25000
Number of HSP's gapped (non-prelim): 11165
length of query: 1562
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1446
effective length of database: 13,855,062
effective search space: 20034419652
effective search space used: 20034419652
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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