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Search of human proteins with 34101282
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2
[Homo sapiens]
(638 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2 ... 1331 0.0
gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform 1... 1289 0.0
gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2 ... 449 e-126
gi|227430287 sodium channel, nonvoltage-gated 1 alpha isoform 3 ... 449 e-126
gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1 [H... 449 e-126
gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo sapi... 301 9e-82
gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo sapi... 285 7e-77
gi|33519442 amiloride-sensitive cation channel 4 isoform 1 [Homo... 127 3e-29
gi|33519444 amiloride-sensitive cation channel 4 isoform 2 [Homo... 126 7e-29
gi|34452695 amiloride-sensitive cation channel 1, neuronal isofo... 115 1e-25
gi|21536349 amiloride-sensitive cation channel 2, neuronal isofo... 113 5e-25
gi|9998944 amiloride-sensitive cation channel 1, neuronal isofor... 111 2e-24
gi|4757710 amiloride-sensitive cation channel 3 isoform a [Homo ... 102 1e-21
gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo ... 102 1e-21
gi|9998948 amiloride-sensitive cation channel 3 isoform c [Homo ... 102 1e-21
gi|21536351 amiloride-sensitive cation channel 2, neuronal isofo... 96 1e-19
gi|31442761 amiloride-sensitive cation channel 5, intestinal [Ho... 93 9e-19
gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo ... 36 0.095
gi|49472841 A kinase (PRKA) anchor protein 8-like [Homo sapiens] 36 0.12
gi|126090663 zinc finger homeodomain 4 [Homo sapiens] 35 0.21
gi|150170670 piccolo isoform 2 [Homo sapiens] 35 0.21
gi|150378539 piccolo isoform 1 [Homo sapiens] 35 0.21
gi|13376146 zinc finger and BTB domain containing 3 [Homo sapiens] 35 0.21
gi|110556644 zinc finger protein, multitype 1 [Homo sapiens] 35 0.21
gi|40018640 parafibromin [Homo sapiens] 34 0.36
gi|239757409 PREDICTED: similar to zinc finger protein 208 [Homo... 34 0.36
gi|239751624 PREDICTED: hypothetical protein XP_002347938 [Homo ... 34 0.36
gi|239746371 PREDICTED: similar to zinc finger protein 208 [Homo... 34 0.36
gi|239746135 PREDICTED: hypothetical protein XP_002344205 [Homo ... 34 0.36
gi|28872814 semaphorin 4G [Homo sapiens] 34 0.36
>gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2
[Homo sapiens]
Length = 638
Score = 1331 bits (3445), Expect = 0.0
Identities = 638/638 (100%), Positives = 638/638 (100%)
Query: 1 MAEHRSMDGRMEAATRGGSHLQAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELL 60
MAEHRSMDGRMEAATRGGSHLQAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELL
Sbjct: 1 MAEHRSMDGRMEAATRGGSHLQAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELL 60
Query: 61 TFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVS 120
TFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVS
Sbjct: 61 TFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVS 120
Query: 121 VHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAALSATVPR 180
VHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAALSATVPR
Sbjct: 121 VHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAALSATVPR 180
Query: 181 HEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDI 240
HEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDI
Sbjct: 181 HEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDI 240
Query: 241 LALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGI 300
LALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGI
Sbjct: 241 LALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGI 300
Query: 301 THGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEV 360
THGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEV
Sbjct: 301 THGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEV 360
Query: 361 HRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEY 420
HRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEY
Sbjct: 361 HRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEY 420
Query: 421 CSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLA 480
CSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLA
Sbjct: 421 CSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLA 480
Query: 481 TLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASV 540
TLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASV
Sbjct: 481 TLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASV 540
Query: 541 LSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPPPAGGTSD 600
LSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPPPAGGTSD
Sbjct: 541 LSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPPPAGGTSD 600
Query: 601 DPEPSGPHLPRVMLPGVLAGVSAEESWAGPQPLETLDT 638
DPEPSGPHLPRVMLPGVLAGVSAEESWAGPQPLETLDT
Sbjct: 601 DPEPSGPHLPRVMLPGVLAGVSAEESWAGPQPLETLDT 638
>gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform 1
[Homo sapiens]
Length = 704
Score = 1289 bits (3336), Expect = 0.0
Identities = 617/617 (100%), Positives = 617/617 (100%)
Query: 22 QAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGN 81
QAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGN
Sbjct: 88 QAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGN 147
Query: 82 RLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRP 141
RLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRP
Sbjct: 148 RLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRP 207
Query: 142 SPVLRHLELLDEFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGS 201
SPVLRHLELLDEFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGS
Sbjct: 208 SPVLRHLELLDEFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGS 267
Query: 202 RVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVL 261
RVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVL
Sbjct: 268 RVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVL 327
Query: 262 SCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLST 321
SCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLST
Sbjct: 328 SCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLST 387
Query: 322 LAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVEL 381
LAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVEL
Sbjct: 388 LAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVEL 447
Query: 382 LHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLE 441
LHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLE
Sbjct: 448 LHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLE 507
Query: 442 THRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKI 501
THRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKI
Sbjct: 508 THRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKI 567
Query: 502 NIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLG 561
NIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLG
Sbjct: 568 NIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLG 627
Query: 562 GRRLRRAWFSWPRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGV 621
GRRLRRAWFSWPRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGV
Sbjct: 628 GRRLRRAWFSWPRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGV 687
Query: 622 SAEESWAGPQPLETLDT 638
SAEESWAGPQPLETLDT
Sbjct: 688 SAEESWAGPQPLETLDT 704
>gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2
[Homo sapiens]
Length = 728
Score = 449 bits (1155), Expect = e-126
Identities = 229/588 (38%), Positives = 338/588 (57%), Gaps = 31/588 (5%)
Query: 32 GP-PSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGL 90
GP P+AP P E +E L+E S+REL FFC N TIHGAIRLVCS+ NR+KT W +
Sbjct: 91 GPEPAAPQQPTAE--EEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAV 148
Query: 91 LSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLEL 150
L L + WQ GLLF ++ PV + ++++S++ + P VT+C NP R + LE
Sbjct: 149 LWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEE 208
Query: 151 LDEFARENIDSLYNVNL-------SKGRAALSATVP------RHEPPFHLDREIR--LQR 195
LD + + LY + S+ R L T+P R PP H R R
Sbjct: 209 LDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASS 268
Query: 196 LSHSGSRV-----RVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWED 250
L + +V ++GF+LCN DCFY+ Y+SGV AV++WY FHY++IL+ LP
Sbjct: 269 LRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPS 328
Query: 251 SHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVD-----GVWTAQRPGITHGVG 305
G+F+ +C ++ + C + FHHP YG+CYT + +W + PGI +G+
Sbjct: 329 LEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLS 388
Query: 306 LVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGS 365
L+LR EQ +PLLST+ G RVMVHG++ F+ F++RPG E +IS+R++ + RLG
Sbjct: 389 LMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGG 448
Query: 366 PYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSAR 425
YG CT G V VE L+ + YT+Q C+ SCFQ+ M++ C C Y +P P EYC +
Sbjct: 449 DYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRK 508
Query: 426 HPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQ 485
H +WG+C+Y+L D + L C ++C +PC ++++LS G SRWPS S W L Q
Sbjct: 509 HSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQ 568
Query: 486 GLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLE 545
+ + +R+ +AK+NI ++ELNY++ E+P ++ LLS +GS SLWFG+SVLS++E
Sbjct: 569 N-NYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVE 627
Query: 546 LLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPP 593
+ EL+ D + ++ RR R + W GA + + PP
Sbjct: 628 MAELVFDLLVIMFLMLLRRFRSRY--WSPGRGGRGAQEVASTLASSPP 673
>gi|227430287 sodium channel, nonvoltage-gated 1 alpha isoform 3
[Homo sapiens]
Length = 692
Score = 449 bits (1155), Expect = e-126
Identities = 229/588 (38%), Positives = 338/588 (57%), Gaps = 31/588 (5%)
Query: 32 GP-PSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGL 90
GP P+AP P E +E L+E S+REL FFC N TIHGAIRLVCS+ NR+KT W +
Sbjct: 55 GPEPAAPQQPTAE--EEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAV 112
Query: 91 LSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLEL 150
L L + WQ GLLF ++ PV + ++++S++ + P VT+C NP R + LE
Sbjct: 113 LWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEE 172
Query: 151 LDEFARENIDSLYNVNL-------SKGRAALSATVP------RHEPPFHLDREIR--LQR 195
LD + + LY + S+ R L T+P R PP H R R
Sbjct: 173 LDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASS 232
Query: 196 LSHSGSRV-----RVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWED 250
L + +V ++GF+LCN DCFY+ Y+SGV AV++WY FHY++IL+ LP
Sbjct: 233 LRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPS 292
Query: 251 SHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVD-----GVWTAQRPGITHGVG 305
G+F+ +C ++ + C + FHHP YG+CYT + +W + PGI +G+
Sbjct: 293 LEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLS 352
Query: 306 LVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGS 365
L+LR EQ +PLLST+ G RVMVHG++ F+ F++RPG E +IS+R++ + RLG
Sbjct: 353 LMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGG 412
Query: 366 PYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSAR 425
YG CT G V VE L+ + YT+Q C+ SCFQ+ M++ C C Y +P P EYC +
Sbjct: 413 DYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRK 472
Query: 426 HPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQ 485
H +WG+C+Y+L D + L C ++C +PC ++++LS G SRWPS S W L Q
Sbjct: 473 HSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQ 532
Query: 486 GLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLE 545
+ + +R+ +AK+NI ++ELNY++ E+P ++ LLS +GS SLWFG+SVLS++E
Sbjct: 533 N-NYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVE 591
Query: 546 LLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPP 593
+ EL+ D + ++ RR R + W GA + + PP
Sbjct: 592 MAELVFDLLVIMFLMLLRRFRSRY--WSPGRGGRGAQEVASTLASSPP 637
>gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1 [Homo
sapiens]
Length = 669
Score = 449 bits (1155), Expect = e-126
Identities = 229/588 (38%), Positives = 338/588 (57%), Gaps = 31/588 (5%)
Query: 32 GP-PSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGL 90
GP P+AP P E +E L+E S+REL FFC N TIHGAIRLVCS+ NR+KT W +
Sbjct: 32 GPEPAAPQQPTAE--EEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAV 89
Query: 91 LSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLEL 150
L L + WQ GLLF ++ PV + ++++S++ + P VT+C NP R + LE
Sbjct: 90 LWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEE 149
Query: 151 LDEFARENIDSLYNVNL-------SKGRAALSATVP------RHEPPFHLDREIR--LQR 195
LD + + LY + S+ R L T+P R PP H R R
Sbjct: 150 LDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASS 209
Query: 196 LSHSGSRV-----RVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWED 250
L + +V ++GF+LCN DCFY+ Y+SGV AV++WY FHY++IL+ LP
Sbjct: 210 LRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPS 269
Query: 251 SHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVD-----GVWTAQRPGITHGVG 305
G+F+ +C ++ + C + FHHP YG+CYT + +W + PGI +G+
Sbjct: 270 LEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLS 329
Query: 306 LVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGS 365
L+LR EQ +PLLST+ G RVMVHG++ F+ F++RPG E +IS+R++ + RLG
Sbjct: 330 LMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGG 389
Query: 366 PYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSAR 425
YG CT G V VE L+ + YT+Q C+ SCFQ+ M++ C C Y +P P EYC +
Sbjct: 390 DYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRK 449
Query: 426 HPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQ 485
H +WG+C+Y+L D + L C ++C +PC ++++LS G SRWPS S W L Q
Sbjct: 450 HSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQ 509
Query: 486 GLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLE 545
+ + +R+ +AK+NI ++ELNY++ E+P ++ LLS +GS SLWFG+SVLS++E
Sbjct: 510 N-NYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVE 568
Query: 546 LLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPP 593
+ EL+ D + ++ RR R + W GA + + PP
Sbjct: 569 MAELVFDLLVIMFLMLLRRFRSRY--WSPGRGGRGAQEVASTLASSPP 614
>gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo
sapiens]
Length = 649
Score = 301 bits (772), Expect = 9e-82
Identities = 181/599 (30%), Positives = 290/599 (48%), Gaps = 53/599 (8%)
Query: 55 SFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRP 114
+ +EL+ ++C N HG R+V SRG RL+ W +L A+ + WQ LL +
Sbjct: 24 TIKELMRWYCLNTNTHGCRRIVVSRG-RLRRLLWIGFTLTAVALILWQCALLVFSFY--T 80
Query: 115 VLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGR--- 171
V +++ VH + P VT+C+ NP + S V L L++ RE + SLY S+ R
Sbjct: 81 VSVSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREA 140
Query: 172 ----AALSATVPR--HEPP--------------FHLDREIRL--------QRLSHSGSRV 203
+ PR H P F R+ ++ + H S+
Sbjct: 141 ESWNSVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKRKVGGSIIHKASNVMHIESKQ 200
Query: 204 RVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSC 263
VGF+LC++ DC ++SG+ A+Q+WY HY++I+A +P + + +++C
Sbjct: 201 VVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTC 260
Query: 264 SYDGLDCQARQFRTFHHPTYGSCYTVDG-----VWTAQRPGITHGVGLVLRVEQQPHLPL 318
+DG+ C AR F FHHP +G+CYT + + + G +G+ ++L + ++ + P
Sbjct: 261 FFDGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINEEEYNPF 320
Query: 319 LSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVE 378
L + G +V++H ++ PF+ + +I + E +L PY CT G V
Sbjct: 321 LVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDGSDVP 380
Query: 379 VELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQ 438
+ ++N +Y+ Q CL SCFQ MVE C C Y PLP A YC+ +HP W +C+Y+L++
Sbjct: 381 IRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLHR 440
Query: 439 DLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATL-GEQGLPHQSHRQRSS 497
L C S C C + L+T ++WPS S W L L +QG ++
Sbjct: 441 AFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQGRQVNKKLNKTD 500
Query: 498 LAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALT 557
LAK+ I Y++LN RS+ E+P S+ LLS G LW SV+ ++E++E+
Sbjct: 501 LAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSI 560
Query: 558 LVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPP----PAGGTSDDPEP--SGPHLP 610
+ + + W++W +A P PEA + P PA DD S HLP
Sbjct: 561 IARRQWQKAKEWWAWKQAPPC-------PEAPRSPQGQDNPALDIDDDLPTFNSALHLP 612
>gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo
sapiens]
Length = 640
Score = 285 bits (730), Expect = 7e-77
Identities = 176/605 (29%), Positives = 283/605 (46%), Gaps = 54/605 (8%)
Query: 55 SFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRP 114
+++ELL ++C N HG R++C K W LL+L +CWQ G+ +
Sbjct: 21 TYKELLVWYCDNTNTHGPKRIICEGPK--KKAMWFLLTLLFAALVCWQWGIFIRTYLSWE 78
Query: 115 VLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAA- 173
V +++SV + P VT+C+ +P + S + L+ LDE ++ + LS A
Sbjct: 79 VSVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKDLDELMEAVLERILAPELSHANATR 138
Query: 174 -LSATVPRHEPPFHLDRE-------IRLQRLSHSGSR-------------VRVGFRLCNS 212
L+ ++ H P +D + L +H+G ++ RLC+
Sbjct: 139 NLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSSSASEKICNAHGCKMAMRLCSL 198
Query: 213 TGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQA 272
C +R +TS A+ +WY +I A +P +L+C + C
Sbjct: 199 NRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQELVEMSYPGEQMILACLFGAEPCNY 258
Query: 273 RQFRTFHHPTYGSCYTVDGVWTAQ-----RPGITHGVGLVLRVEQQPHLPLLSTLAGIRV 327
R F + +P YG+CY + T + PG G+ L+L + Q+ ++P L++ AG+R+
Sbjct: 259 RNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRL 318
Query: 328 MVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLH---N 384
M+H + PF+ GTE +I + D++ R+G PY CT G V V+ + N
Sbjct: 319 MLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYN 378
Query: 385 TSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHR 444
T+Y+ QACL SCFQ M+ C+CG+YL+PLP G +YC++ P W HC+ L + R
Sbjct: 379 TTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSV-AQR 437
Query: 445 LPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLG-EQGLPHQSHRQRSSLAKINI 503
C C C ++ +K++ + WPS S W L E+ R + K+NI
Sbjct: 438 ETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNI 497
Query: 504 VYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLV---- 559
+QE NYR++EE+ ++ LLS +G W G SVL L+E E+++D +T++
Sbjct: 498 YFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVA 557
Query: 560 -LGGRRLRRAWFSWPRASP-------ASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPR 611
R RRA S+ P A +P+ + P G P PS LP
Sbjct: 558 LAKSLRQRRAQASYAGPPPTVAELVEAHTNFGFQPDTAPRSPNTG-----PYPSEQALP- 611
Query: 612 VMLPG 616
+PG
Sbjct: 612 --IPG 614
>gi|33519442 amiloride-sensitive cation channel 4 isoform 1 [Homo
sapiens]
Length = 666
Score = 127 bits (319), Expect = 3e-29
Identities = 147/606 (24%), Positives = 241/606 (39%), Gaps = 128/606 (21%)
Query: 39 PPPKEGHQE----GLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLG 94
P KE E G V A+ R+L TF T+ T+HG R + L+ T W L L
Sbjct: 145 PKEKEAGDEQSLLGAVAPGAAPRDLATFASTS-TLHGLGRACGPGPHGLRRTLWALALLT 203
Query: 95 ALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEF 154
+L A +Q L + RP L+A+ +P P+PV +
Sbjct: 204 SLAAFLYQAAGLARGYLTRPHLVAM-----------------DPAAPAPVAGFPAV---- 242
Query: 155 ARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTG 214
+L N+N + A A + FHL L G R
Sbjct: 243 ------TLCNINRFRHSALSDADI------FHLANLTGLPPKDRDGHR------------ 278
Query: 215 GDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQ 274
AA + VDIL + G Q + SC++ G C A
Sbjct: 279 ------------AAGLRYPEPDMVDIL--------NRTGHQLADMLKSCNFSGHHCSASN 318
Query: 275 FRTFHHPTYGSCYTVDGVWTAQRP----GITHGVGLVLRVEQQPHLPL------LSTLAG 324
F + YG CYT + + P G+ G+ ++L ++Q+ +LP+ S AG
Sbjct: 319 FSVVY-TRYGKCYTFNADPRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAG 377
Query: 325 IRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHN 384
IRV +H + P++ F V PG + +S +E + L P+G+C A E E EL
Sbjct: 378 IRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPELQGY 437
Query: 385 TSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHR 444
++Y+ AC + C ++ +++ C C + +P C +Y + H
Sbjct: 438 SAYSVSACRLRCEKEAVLQRCHC--RMVHMPGNETICPP-----------NIYIECADHT 484
Query: 445 L---------PCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQR 495
L PC CP PC + + R P+ SA + L + ++++ +
Sbjct: 485 LDSLGGGPEGPCF--CPTPCNLTRYGKEISMVRIPNRGSARY----LARKYNRNETYIRE 538
Query: 496 SSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASA 555
+ L +++ ++ L ++E+ Y + LL +G L+ GAS+L+LLE+L+ + + S
Sbjct: 539 NFLV-LDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVS- 596
Query: 556 LTLVLGGRRLRRAWF--SWPRASPASGASS--IKPEASQMPPPAGGTSDD-------PEP 604
RL+R W P + G S+ ++ Q P P+ G ++ P
Sbjct: 597 ------WDRLKRVWRRPKTPLRTSTGGISTLGLQELKEQSPCPSLGRAEGGGVSSLLPNH 650
Query: 605 SGPHLP 610
PH P
Sbjct: 651 HHPHGP 656
>gi|33519444 amiloride-sensitive cation channel 4 isoform 2 [Homo
sapiens]
Length = 647
Score = 126 bits (316), Expect = 7e-29
Identities = 147/599 (24%), Positives = 237/599 (39%), Gaps = 133/599 (22%)
Query: 39 PPPKEGHQE----GLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLG 94
P KE E G V A+ R+L TF T+ T+HG R + L+ T W L L
Sbjct: 145 PKEKEAGDEQSLLGAVAPGAAPRDLATFASTS-TLHGLGRACGPGPHGLRRTLWALALLT 203
Query: 95 ALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEF 154
+L A +Q L + RP L+A+ +P P+PV +
Sbjct: 204 SLAAFLYQAAGLARGYLTRPHLVAM-----------------DPAAPAPVAGFPAV---- 242
Query: 155 ARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTG 214
+L N+N + A A + FHL L G R
Sbjct: 243 ------TLCNINRFRHSALSDADI------FHLANLTGLPPKDRDGHR------------ 278
Query: 215 GDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQ 274
AA + VDIL + G Q + SC++ G C A
Sbjct: 279 ------------AAGLRYPEPDMVDIL--------NRTGHQLADMLKSCNFSGHHCSASN 318
Query: 275 FRTFHHPTYGSCYTVDGVWTAQRP----GITHGVGLVLRVEQQPHLPL------LSTLAG 324
F + YG CYT + + P G+ G+ ++L ++Q+ +LP+ S AG
Sbjct: 319 FSVVY-TRYGKCYTFNADPRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAG 377
Query: 325 IRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHN 384
IRV +H + P++ F V PG + +S +E + L P+G+C A E E EL
Sbjct: 378 IRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPELQGY 437
Query: 385 TSYTRQACLVSCFQQLMVETCSCGYYLHP--LPAGAEYCSSARHPAWGHCFYRLYQDLET 442
++Y+ AC + C ++ +++ C C P L G E G CF
Sbjct: 438 SAYSVSACRLRCEKEAVLQRCHCRMVHMPDSLGGGPE----------GPCF--------- 478
Query: 443 HRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKIN 502
CP PC + + R P+ SA + L + ++++ + + L ++
Sbjct: 479 --------CPTPCNLTRYGKEISMVRIPNRGSARY----LARKYNRNETYIRENFLV-LD 525
Query: 503 IVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGG 562
+ ++ L ++E+ Y + LL +G L+ GAS+L+LLE+L+ + + S
Sbjct: 526 VFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVS-------W 578
Query: 563 RRLRRAWF--SWPRASPASGASS--IKPEASQMPPPAGGTSDD-------PEPSGPHLP 610
RL+R W P + G S+ ++ Q P P+ G ++ P PH P
Sbjct: 579 DRLKRVWRRPKTPLRTSTGGISTLGLQELKEQSPCPSLGRAEGGGVSSLLPNHHHPHGP 637
>gi|34452695 amiloride-sensitive cation channel 1, neuronal isoform
1 [Homo sapiens]
Length = 563
Score = 115 bits (288), Expect = 1e-25
Identities = 79/321 (24%), Positives = 147/321 (45%), Gaps = 28/321 (8%)
Query: 244 LPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDG------VWTAQR 297
+ AA+ D G Q +LSC Y G C F + YG CY + + T +
Sbjct: 203 ISAAFMDRLGHQLEDMLLSCKYRGELCGPHNFSSVF-TKYGKCYMFNSGEDGKPLLTTVK 261
Query: 298 PGITHGVGLVLRVEQQPHLPLLSTL------AGIRVMVHGRNHTPFLGHHSFSVRPGTEA 351
G +G+ ++L ++Q +LP+ AG++V +H ++ PF+ F V PG +
Sbjct: 262 GGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQT 321
Query: 352 TISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYL 411
++ +E + L P+G C + G++ + Y+ AC + C + +VE C+C +
Sbjct: 322 FVATQEQRLTYLPPPWGECRSSEMGLDFFPV----YSITACRIDCETRYIVENCNCRM-V 376
Query: 412 HPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPS 471
H +P A +C+ +H L + +++ C + PC + + + PS
Sbjct: 377 H-MPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRT----PCNLTRYNKELSMVKIPS 431
Query: 472 AKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSL 531
SA + E+ ++ ++I ++ LNY ++E+ Y V LL +G
Sbjct: 432 KTSAKYL-----EKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQ 486
Query: 532 CSLWFGASVLSLLELLELLLD 552
L+ GAS+L++LEL + + +
Sbjct: 487 MGLFIGASILTILELFDYIYE 507
>gi|21536349 amiloride-sensitive cation channel 2, neuronal isoform
b [Homo sapiens]
Length = 528
Score = 113 bits (283), Expect = 5e-25
Identities = 128/557 (22%), Positives = 221/557 (39%), Gaps = 90/557 (16%)
Query: 63 FCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFER-----HWHRPVLM 117
F +++T+HG + LK W L LG+L L L + ER H+H V
Sbjct: 21 FASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVL---LCVCTERVQYYFHYHH-VTK 76
Query: 118 AVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAALSAT 177
V + + P VTLC+ N R F++ + + LY+ L+
Sbjct: 77 LDEVAASQLTFPAVTLCNLNEFR-------------FSQVSKNDLYHAG-----ELLALL 118
Query: 178 VPRHE-PPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFH 236
R+E P + E +L+ L + +R + ++++Y
Sbjct: 119 NNRYEIPDTQMADEKQLEILQDKAN-----------------FRSFKPKPFNMREFY--- 158
Query: 237 YVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQ 296
D G +LSC + G C A F+ YG CYT + +
Sbjct: 159 -------------DRAGHDIRDMLLSCHFRGEVCSAEDFKVVF-TRYGKCYTFNSGRDGR 204
Query: 297 ------RPGITHGVGLVLRVEQQPHLPL------LSTLAGIRVMVHGRNHTPFLGHHSFS 344
+ G +G+ ++L ++Q +LP+ S AGI+V +H ++ PF+ F
Sbjct: 205 PRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFG 264
Query: 345 VRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVET 404
V PG + ++ +E + L P+G C A ++ +L SY+ AC + C + +VE
Sbjct: 265 VAPGFQTFVACQEQRLIYLPPPWGTCKA--VTMDSDLDFFDSYSITACRIDCETRYLVEN 322
Query: 405 CSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLST 464
C+C + +P A YC+ ++ +E + C C PC + +
Sbjct: 323 CNC--RMVHMPGDAPYCTPEQYKECADPALDFL--VEKDQEYCV--CEMPCNLTRYGKEL 376
Query: 465 GTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQL 524
+ PS SA + + ++ ++I ++ LNY ++E+ Y + L
Sbjct: 377 SMVKIPSKASAKYLAKKFNK-----SEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGL 431
Query: 525 LSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSI 584
L +G L+ GAS+L++LEL + + L G+ + A S A +
Sbjct: 432 LGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDV 491
Query: 585 K---PEASQMPPPAGGT 598
K P S PAG T
Sbjct: 492 KRHNPCESLRGHPAGMT 508
>gi|9998944 amiloride-sensitive cation channel 1, neuronal isoform 2
[Homo sapiens]
Length = 512
Score = 111 bits (277), Expect = 2e-24
Identities = 73/305 (23%), Positives = 141/305 (46%), Gaps = 28/305 (9%)
Query: 260 VLSCSYDGLDCQARQFRTFHHPTYGSCYTVDG------VWTAQRPGITHGVGLVLRVEQQ 313
+L C + G +C + F T YG CY + + T + G +G+ ++L ++Q
Sbjct: 168 MLYCKFKGQECGHQDFTTVF-TKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQD 226
Query: 314 PHLPLLSTL------AGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPY 367
+LP+ AG++V +H ++ PF+ F V PG + ++ +E + L P+
Sbjct: 227 EYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPW 286
Query: 368 GHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHP 427
G C + G++ + Y+ AC + C + +VE C+C +H +P A +C+ +H
Sbjct: 287 GECRSSEMGLDFFPV----YSITACRIDCETRYIVENCNCRM-VH-MPGDAPFCTPEQHK 340
Query: 428 AWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGL 487
L + +++ C + PC + + + PS SA + E+
Sbjct: 341 ECAEPALGLLAEKDSNYCLCRT----PCNLTRYNKELSMVKIPSKTSAKYL-----EKKF 391
Query: 488 PHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELL 547
++ ++I ++ LNY ++E+ Y V LL +G L+ GAS+L++LEL
Sbjct: 392 NKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELF 451
Query: 548 ELLLD 552
+ + +
Sbjct: 452 DYIYE 456
>gi|4757710 amiloride-sensitive cation channel 3 isoform a [Homo
sapiens]
Length = 531
Score = 102 bits (254), Expect = 1e-21
Identities = 80/316 (25%), Positives = 138/316 (43%), Gaps = 37/316 (11%)
Query: 260 VLSCSYDGLDCQARQFRTFHHPTYGSCYT----VDG--VWTAQRPGITHGVGLVLRVEQQ 313
+L C + G C F T G CYT DG + T R G+ +G+ ++L V+Q+
Sbjct: 161 LLDCRFRGQPCGPENFTTIF-TRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQE 219
Query: 314 PHLPLLSTL------AGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPY 367
+LP+ GIRV +H + P + V PG + +S ++ ++ L P+
Sbjct: 220 EYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPW 279
Query: 368 GHCTAGG-----EGVEVELLHNTS------YTRQACLVSCFQQLMVETCSCGYYLHPLPA 416
G C++ E + L + S YT C ++C + + C C +P
Sbjct: 280 GDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVY--MPG 337
Query: 417 GAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAG 476
CS ++ H D + C CP PC + + R PS +A
Sbjct: 338 DVPVCSPQQYKNCAHPAI----DAMLRKDSCA--CPNPCASTRYAKELSMVRIPSRAAAR 391
Query: 477 WTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWF 536
+ L +++ + LA ++I ++ LNY +VE+ Y + +LL +G L+
Sbjct: 392 FLARKLNRS----EAYIAENVLA-LDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFI 446
Query: 537 GASVLSLLELLELLLD 552
GAS+L++LE+L+ L +
Sbjct: 447 GASLLTILEILDYLCE 462
>gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo
sapiens]
Length = 549
Score = 102 bits (254), Expect = 1e-21
Identities = 80/316 (25%), Positives = 138/316 (43%), Gaps = 37/316 (11%)
Query: 260 VLSCSYDGLDCQARQFRTFHHPTYGSCYT----VDG--VWTAQRPGITHGVGLVLRVEQQ 313
+L C + G C F T G CYT DG + T R G+ +G+ ++L V+Q+
Sbjct: 161 LLDCRFRGQPCGPENFTTIF-TRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQE 219
Query: 314 PHLPLLSTL------AGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPY 367
+LP+ GIRV +H + P + V PG + +S ++ ++ L P+
Sbjct: 220 EYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPW 279
Query: 368 GHCTAGG-----EGVEVELLHNTS------YTRQACLVSCFQQLMVETCSCGYYLHPLPA 416
G C++ E + L + S YT C ++C + + C C +P
Sbjct: 280 GDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVY--MPG 337
Query: 417 GAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAG 476
CS ++ H D + C CP PC + + R PS +A
Sbjct: 338 DVPVCSPQQYKNCAHPAI----DAMLRKDSCA--CPNPCASTRYAKELSMVRIPSRAAAR 391
Query: 477 WTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWF 536
+ L +++ + LA ++I ++ LNY +VE+ Y + +LL +G L+
Sbjct: 392 FLARKLNRS----EAYIAENVLA-LDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFI 446
Query: 537 GASVLSLLELLELLLD 552
GAS+L++LE+L+ L +
Sbjct: 447 GASLLTILEILDYLCE 462
>gi|9998948 amiloride-sensitive cation channel 3 isoform c [Homo
sapiens]
Length = 543
Score = 102 bits (254), Expect = 1e-21
Identities = 80/316 (25%), Positives = 138/316 (43%), Gaps = 37/316 (11%)
Query: 260 VLSCSYDGLDCQARQFRTFHHPTYGSCYT----VDG--VWTAQRPGITHGVGLVLRVEQQ 313
+L C + G C F T G CYT DG + T R G+ +G+ ++L V+Q+
Sbjct: 161 LLDCRFRGQPCGPENFTTIF-TRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQE 219
Query: 314 PHLPLLSTL------AGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPY 367
+LP+ GIRV +H + P + V PG + +S ++ ++ L P+
Sbjct: 220 EYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPW 279
Query: 368 GHCTAGG-----EGVEVELLHNTS------YTRQACLVSCFQQLMVETCSCGYYLHPLPA 416
G C++ E + L + S YT C ++C + + C C +P
Sbjct: 280 GDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVY--MPG 337
Query: 417 GAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAG 476
CS ++ H D + C CP PC + + R PS +A
Sbjct: 338 DVPVCSPQQYKNCAHPAI----DAMLRKDSCA--CPNPCASTRYAKELSMVRIPSRAAAR 391
Query: 477 WTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWF 536
+ L +++ + LA ++I ++ LNY +VE+ Y + +LL +G L+
Sbjct: 392 FLARKLNRS----EAYIAENVLA-LDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFI 446
Query: 537 GASVLSLLELLELLLD 552
GAS+L++LE+L+ L +
Sbjct: 447 GASLLTILEILDYLCE 462
>gi|21536351 amiloride-sensitive cation channel 2, neuronal isoform
a [Homo sapiens]
Length = 574
Score = 95.9 bits (237), Expect = 1e-19
Identities = 107/484 (22%), Positives = 191/484 (39%), Gaps = 87/484 (17%)
Query: 63 FCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFER-----HWHRPVLM 117
F +++T+HG + LK W L LG+L L L + ER H+H V
Sbjct: 21 FASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVL---LCVCTERVQYYFHYHH-VTK 76
Query: 118 AVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAALSAT 177
V + + P VTLC+ N R F++ + + LY+ L+
Sbjct: 77 LDEVAASQLTFPAVTLCNLNEFR-------------FSQVSKNDLYHAG-----ELLALL 118
Query: 178 VPRHE-PPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFH 236
R+E P + E +L+ L + +R + ++++Y
Sbjct: 119 NNRYEIPDTQMADEKQLEILQDKAN-----------------FRSFKPKPFNMREFY--- 158
Query: 237 YVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQ 296
D G +LSC + G C A F+ YG CYT + +
Sbjct: 159 -------------DRAGHDIRDMLLSCHFRGEVCSAEDFKVVF-TRYGKCYTFNSGRDGR 204
Query: 297 ------RPGITHGVGLVLRVEQQPHLPL------LSTLAGIRVMVHGRNHTPFLGHHSFS 344
+ G +G+ ++L ++Q +LP+ S AGI+V +H ++ PF+ F
Sbjct: 205 PRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFG 264
Query: 345 VRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVET 404
V PG + ++ +E + L P+G C A ++ +L SY+ AC + C + +VE
Sbjct: 265 VAPGFQTFVACQEQRLIYLPPPWGTCKA--VTMDSDLDFFDSYSITACRIDCETRYLVEN 322
Query: 405 CSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLST 464
C+C + +P A YC+ ++ +E + C C PC + +
Sbjct: 323 CNC--RMVHMPGDAPYCTPEQYKECADPALDFL--VEKDQEYCV--CEMPCNLTRYGKEL 376
Query: 465 GTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQL 524
+ PS SA + + ++ ++I ++ LNY ++E+ Y + L
Sbjct: 377 SMVKIPSKASAKYLAKKFNK-----SEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGL 431
Query: 525 LSAM 528
L +
Sbjct: 432 LGEL 435
>gi|31442761 amiloride-sensitive cation channel 5, intestinal [Homo
sapiens]
Length = 505
Score = 92.8 bits (229), Expect = 9e-19
Identities = 78/302 (25%), Positives = 131/302 (43%), Gaps = 27/302 (8%)
Query: 260 VLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGIT----HGVGLVLRVEQQPH 315
+L C + G C + F YG+C+T + T Q G+ L+ V Q+
Sbjct: 182 LLDCEFFGKPCSPKDFAHVF-TEYGNCFTFNHGETLQAKRKVSVSGRGLSLLFNVNQEAF 240
Query: 316 L--PLLSTL-AGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTA 372
P L + AGI ++H P G A ++IR+ + P+G C
Sbjct: 241 TDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNP 300
Query: 373 GGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHP---LPAGAEYCSSARHPAW 429
++L + +SY+ CL C Q + + C C +L P + + S P
Sbjct: 301 N-----IKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVL 355
Query: 430 GHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPH 489
H ++ + TH S CP C E + + S +PS K+ + L +
Sbjct: 356 DHIEFKDLCTVGTHN----SSCPVSCEEIEYPATISYSSFPSQKALKYLSKKL------N 405
Query: 490 QSHRQ-RSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLE 548
QS + R +L KI I Y +LNY+ ++ SV +LL+ +G L+ GAS+++++E++E
Sbjct: 406 QSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIE 465
Query: 549 LL 550
L
Sbjct: 466 YL 467
Score = 33.5 bits (75), Expect = 0.62
Identities = 18/76 (23%), Positives = 40/76 (52%), Gaps = 2/76 (2%)
Query: 63 FCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVSV- 121
F + + HG +V +R ++++ W ++ LG++ + WQ+ + ++ P ++ V
Sbjct: 41 FAISTSFHGIHNIVQNR-SKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQ 99
Query: 122 HSERKLLPLVTLCDGN 137
+ E+ P VT C+ N
Sbjct: 100 YVEKMEFPAVTFCNLN 115
>gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo
sapiens]
Length = 1214
Score = 36.2 bits (82), Expect = 0.095
Identities = 20/48 (41%), Positives = 25/48 (52%), Gaps = 1/48 (2%)
Query: 23 AAAQTPPRPGPPSAPPPPPKEGHQEGLVEL-PASFRELLTFFCTNATI 69
AAA P PGPP PPPPP E + E P S ++L+ T+ I
Sbjct: 2 AAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQI 49
>gi|49472841 A kinase (PRKA) anchor protein 8-like [Homo sapiens]
Length = 646
Score = 35.8 bits (81), Expect = 0.12
Identities = 18/46 (39%), Positives = 21/46 (45%), Gaps = 2/46 (4%)
Query: 9 GRMEAATRGGSHLQAAAQTPPRPGPP--SAPPPPPKEGHQEGLVEL 52
G + G + A PP P P S PPPPP E +EG V L
Sbjct: 573 GEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPPPPPEEEEEGAVPL 618
>gi|126090663 zinc finger homeodomain 4 [Homo sapiens]
Length = 3571
Score = 35.0 bits (79), Expect = 0.21
Identities = 14/21 (66%), Positives = 14/21 (66%)
Query: 21 LQAAAQTPPRPGPPSAPPPPP 41
LQA TPP P PP PPPPP
Sbjct: 1990 LQAPPPTPPPPPPPPPPPPPP 2010
Score = 30.4 bits (67), Expect = 5.2
Identities = 12/31 (38%), Positives = 18/31 (58%)
Query: 23 AAAQTPPRPGPPSAPPPPPKEGHQEGLVELP 53
++ +TPP P PP PP P + G V++P
Sbjct: 1953 SSPETPPPPPPPPPLPPAPPQPSSMGPVKIP 1983
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 35.0 bits (79), Expect = 0.21
Identities = 14/23 (60%), Positives = 15/23 (65%)
Query: 19 SHLQAAAQTPPRPGPPSAPPPPP 41
S L +AQ PP P PP PPPPP
Sbjct: 2397 SSLDISAQPPPPPPPPPPPPPPP 2419
Score = 30.0 bits (66), Expect = 6.8
Identities = 11/21 (52%), Positives = 12/21 (57%)
Query: 21 LQAAAQTPPRPGPPSAPPPPP 41
+ A PP P PP PPPPP
Sbjct: 2401 ISAQPPPPPPPPPPPPPPPPP 2421
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 35.0 bits (79), Expect = 0.21
Identities = 14/23 (60%), Positives = 15/23 (65%)
Query: 19 SHLQAAAQTPPRPGPPSAPPPPP 41
S L +AQ PP P PP PPPPP
Sbjct: 2397 SSLDISAQPPPPPPPPPPPPPPP 2419
Score = 30.0 bits (66), Expect = 6.8
Identities = 11/21 (52%), Positives = 12/21 (57%)
Query: 21 LQAAAQTPPRPGPPSAPPPPP 41
+ A PP P PP PPPPP
Sbjct: 2401 ISAQPPPPPPPPPPPPPPPPP 2421
>gi|13376146 zinc finger and BTB domain containing 3 [Homo sapiens]
Length = 574
Score = 35.0 bits (79), Expect = 0.21
Identities = 20/50 (40%), Positives = 26/50 (52%), Gaps = 4/50 (8%)
Query: 571 SWPRASPASGASSIKPEASQMPPPAG----GTSDDPEPSGPHLPRVMLPG 616
++P GA +PEA + P AG G SD P+ PHLP +LPG
Sbjct: 379 AFPSGGAVYGAQPSQPEAFEDPGAAGLEEVGPSDHFLPTDPHLPYHLLPG 428
>gi|110556644 zinc finger protein, multitype 1 [Homo sapiens]
Length = 1006
Score = 35.0 bits (79), Expect = 0.21
Identities = 20/50 (40%), Positives = 23/50 (46%), Gaps = 4/50 (8%)
Query: 7 MDGRMEAATRGGSHLQAAAQTPPRPGPPSA----PPPPPKEGHQEGLVEL 52
M+ R E G SH++ A P P PPSA PPP P G EL
Sbjct: 19 MEAREEVQLVGASHMEQKATAPEAPSPPSADVNSPPPLPPPTSPGGPKEL 68
>gi|40018640 parafibromin [Homo sapiens]
Length = 531
Score = 34.3 bits (77), Expect = 0.36
Identities = 18/54 (33%), Positives = 30/54 (55%), Gaps = 3/54 (5%)
Query: 11 MEAATRGGSHLQA---AAQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELLT 61
+++ T G S + AAQ PRP + PPP K+G + ++ +PA+ L+T
Sbjct: 320 LKSVTEGASARKTQTPAAQPVPRPVSQARPPPNQKKGSRTPIIIIPAATTSLIT 373
>gi|239757409 PREDICTED: similar to zinc finger protein 208 [Homo
sapiens]
Length = 1059
Score = 34.3 bits (77), Expect = 0.36
Identities = 15/32 (46%), Positives = 16/32 (50%)
Query: 10 RMEAATRGGSHLQAAAQTPPRPGPPSAPPPPP 41
R E G H +A A P PGPP PPP P
Sbjct: 41 RFEPMELYGEHAKAVAALPCAPGPPPQPPPQP 72
>gi|239751624 PREDICTED: hypothetical protein XP_002347938 [Homo
sapiens]
Length = 244
Score = 34.3 bits (77), Expect = 0.36
Identities = 18/43 (41%), Positives = 24/43 (55%), Gaps = 1/43 (2%)
Query: 1 MAEHRSMDGRMEAATRGGSHLQAAAQTPPRPGPPS-APPPPPK 42
+AE + GR+ A +HLQ A PRP P + APPP P+
Sbjct: 126 VAEQHRLVGRVAQAQLAHAHLQLAQPARPRPQPRTRAPPPGPR 168
>gi|239746371 PREDICTED: similar to zinc finger protein 208 [Homo
sapiens]
Length = 1059
Score = 34.3 bits (77), Expect = 0.36
Identities = 15/32 (46%), Positives = 16/32 (50%)
Query: 10 RMEAATRGGSHLQAAAQTPPRPGPPSAPPPPP 41
R E G H +A A P PGPP PPP P
Sbjct: 41 RFEPMELYGEHAKAVAALPCAPGPPPQPPPQP 72
>gi|239746135 PREDICTED: hypothetical protein XP_002344205 [Homo
sapiens]
Length = 244
Score = 34.3 bits (77), Expect = 0.36
Identities = 18/43 (41%), Positives = 24/43 (55%), Gaps = 1/43 (2%)
Query: 1 MAEHRSMDGRMEAATRGGSHLQAAAQTPPRPGPPS-APPPPPK 42
+AE + GR+ A +HLQ A PRP P + APPP P+
Sbjct: 126 VAEQHRLVGRVAQAQLAHAHLQLAQPARPRPQPRTRAPPPGPR 168
>gi|28872814 semaphorin 4G [Homo sapiens]
Length = 843
Score = 34.3 bits (77), Expect = 0.36
Identities = 14/29 (48%), Positives = 16/29 (55%)
Query: 31 PGPPSAPPPPPKEGHQEGLVELPASFREL 59
P PP PPPPP GLV LP+ R +
Sbjct: 768 PAPPPPPPPPPPAELTNGLVALPSRLRRM 796
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.438
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,170,601
Number of Sequences: 37866
Number of extensions: 1630277
Number of successful extensions: 17834
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 161
Number of HSP's successfully gapped in prelim test: 103
Number of HSP's that attempted gapping in prelim test: 14838
Number of HSP's gapped (non-prelim): 2500
length of query: 638
length of database: 18,247,518
effective HSP length: 109
effective length of query: 529
effective length of database: 14,120,124
effective search space: 7469545596
effective search space used: 7469545596
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.