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Search of human proteins with 33636738
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33636738 cAMP-dependent protein kinase catalytic subunit
beta isoform 1 [Homo sapiens]
(398 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 818 0.0
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 688 0.0
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 644 0.0
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 642 0.0
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 570 e-163
gi|46909587 cAMP-dependent protein kinase catalytic subunit beta... 492 e-139
gi|4826948 protein kinase, X-linked [Homo sapiens] 374 e-103
gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [H... 280 2e-75
gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Ho... 280 2e-75
gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens] 278 8e-75
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 269 4e-72
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 269 4e-72
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 269 4e-72
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 269 4e-72
gi|4502023 AKT2 kinase [Homo sapiens] 268 6e-72
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 268 8e-72
gi|62241015 AKT1 kinase [Homo sapiens] 265 4e-71
gi|62241013 AKT1 kinase [Homo sapiens] 265 4e-71
gi|62241011 AKT1 kinase [Homo sapiens] 265 4e-71
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 264 9e-71
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 264 1e-70
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 264 1e-70
gi|5453974 protein kinase N2 [Homo sapiens] 254 1e-67
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 249 2e-66
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 245 4e-65
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 245 4e-65
gi|28557781 protein kinase C, eta [Homo sapiens] 245 6e-65
gi|4506067 protein kinase C, alpha [Homo sapiens] 244 1e-64
gi|4885563 protein kinase C, epsilon [Homo sapiens] 241 8e-64
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 239 3e-63
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 818 bits (2112), Expect = 0.0
Identities = 398/398 (100%), Positives = 398/398 (100%)
Query: 1 MAAYREPPCNQYTGTTTALQKLEGFASRLFHRHSKGTAHDQKTALENDSLHFSEHTALWD 60
MAAYREPPCNQYTGTTTALQKLEGFASRLFHRHSKGTAHDQKTALENDSLHFSEHTALWD
Sbjct: 1 MAAYREPPCNQYTGTTTALQKLEGFASRLFHRHSKGTAHDQKTALENDSLHFSEHTALWD 60
Query: 61 RSMKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMK 120
RSMKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMK
Sbjct: 61 RSMKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMK 120
Query: 121 ILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHL 180
ILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHL
Sbjct: 121 ILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHL 180
Query: 181 RRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVK 240
RRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVK
Sbjct: 181 RRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVK 240
Query: 241 GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS 300
GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS
Sbjct: 241 GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS 300
Query: 301 GKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEA 360
GKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEA
Sbjct: 301 GKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEA 360
Query: 361 PFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 398
PFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF
Sbjct: 361 PFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 398
>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
Length = 351
Score = 688 bits (1776), Expect = 0.0
Identities = 336/337 (99%), Positives = 337/337 (100%)
Query: 62 SMKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKI 121
S+KEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKI
Sbjct: 15 SVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKI 74
Query: 122 LDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLR 181
LDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLR
Sbjct: 75 LDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLR 134
Query: 182 RIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG 241
RIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG
Sbjct: 135 RIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG 194
Query: 242 RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 301
RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG
Sbjct: 195 RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 254
Query: 302 KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAP 361
KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAP
Sbjct: 255 KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAP 314
Query: 362 FIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 398
FIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF
Sbjct: 315 FIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 351
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 644 bits (1660), Expect = 0.0
Identities = 313/337 (92%), Positives = 323/337 (95%)
Query: 62 SMKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKI 121
S+KEFLAKAKEDFLKKWE+P QN A L+ FER KTLGTGSFGRVMLVKHK T +YAMKI
Sbjct: 15 SVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKI 74
Query: 122 LDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLR 181
LDKQKVVKLKQIEHTLNEKRILQAVNFPFLV+LE++FKDNSNLYMVMEYVPGGEMFSHLR
Sbjct: 75 LDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLR 134
Query: 182 RIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG 241
RIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID QGYIQVTDFGFAKRVKG
Sbjct: 135 RIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG 194
Query: 242 RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 301
RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG
Sbjct: 195 RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 254
Query: 302 KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAP 361
KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGV+DIK HKWFATTDWIAIYQRKVEAP
Sbjct: 255 KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAP 314
Query: 362 FIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 398
FIPKF+G GDTSNFDDYEEE+IRVSI EKC KEF EF
Sbjct: 315 FIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 351
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 642 bits (1656), Expect = 0.0
Identities = 312/336 (92%), Positives = 322/336 (95%)
Query: 63 MKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKIL 122
+KEFLAKAKEDFLKKWE+P QN A L+ FER KTLGTGSFGRVMLVKHK T +YAMKIL
Sbjct: 8 VKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKIL 67
Query: 123 DKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRR 182
DKQKVVKLKQIEHTLNEKRILQAVNFPFLV+LE++FKDNSNLYMVMEYVPGGEMFSHLRR
Sbjct: 68 DKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRR 127
Query: 183 IGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGR 242
IGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID QGYIQVTDFGFAKRVKGR
Sbjct: 128 IGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR 187
Query: 243 TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK 302
TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK
Sbjct: 188 TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK 247
Query: 303 VRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPF 362
VRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGV+DIK HKWFATTDWIAIYQRKVEAPF
Sbjct: 248 VRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPF 307
Query: 363 IPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 398
IPKF+G GDTSNFDDYEEE+IRVSI EKC KEF EF
Sbjct: 308 IPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 343
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 570 bits (1469), Expect = e-163
Identities = 269/339 (79%), Positives = 305/339 (89%)
Query: 60 DRSMKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAM 119
+ S+ EFLAKA+ DFL +W NP QN A + FER +TLG GSFGRVMLV+H+ T +YAM
Sbjct: 13 EESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAM 72
Query: 120 KILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSH 179
KIL+KQKVVK+KQ+EH LNEKRILQA++FPFLV+L+++FKDNS LY+VMEYVPGGEMFS
Sbjct: 73 KILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSR 132
Query: 180 LRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRV 239
L+R+GRFSEPHA FYAAQ+VL +YLHSLDLI+RDLKPENLLID QGY+QVTDFGFAKRV
Sbjct: 133 LQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRV 192
Query: 240 KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 299
KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMA G+PPF+ADQPIQIYEKIV
Sbjct: 193 KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIV 252
Query: 300 SGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVE 359
SG+VRFPS SSDLK LLR+LLQVDLTKRFGNL+NGV DIK HKWFATT WIAIY++KVE
Sbjct: 253 SGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVE 312
Query: 360 APFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 398
APFIPK+ G GD SNFDDYEEE++R+SI EKCAKEF EF
Sbjct: 313 APFIPKYTGPGDASNFDDYEEEELRISINEKCAKEFSEF 351
>gi|46909587 cAMP-dependent protein kinase catalytic subunit beta
isoform 3 [Homo sapiens]
Length = 257
Score = 492 bits (1266), Expect = e-139
Identities = 240/241 (99%), Positives = 241/241 (100%)
Query: 62 SMKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKI 121
S+KEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKI
Sbjct: 15 SVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKI 74
Query: 122 LDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLR 181
LDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLR
Sbjct: 75 LDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLR 134
Query: 182 RIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG 241
RIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG
Sbjct: 135 RIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG 194
Query: 242 RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 301
RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG
Sbjct: 195 RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 254
Query: 302 K 302
K
Sbjct: 255 K 255
>gi|4826948 protein kinase, X-linked [Homo sapiens]
Length = 358
Score = 374 bits (959), Expect = e-103
Identities = 165/295 (55%), Positives = 225/295 (76%)
Query: 88 LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 147
L+DF+ T+GTG+FGRV LVK K + ++A+K++ V++LKQ +H NEK +L+ V+
Sbjct: 46 LQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVS 105
Query: 148 FPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 207
PFL+RL + + D LYM+MEYVPGGE+FS+LR GRFS FY+A+I+ EYLHS
Sbjct: 106 HPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHS 165
Query: 208 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAV 267
+++YRDLKPEN+L+D G+I++TDFGFAK++ RTWTLCGTPEYLAPE+I SKG+ +AV
Sbjct: 166 KEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAV 225
Query: 268 DWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTK 327
DWWALG+LI+EM +G+PPFF D P IY+KI++GK+ FP H +KDL++ LL VD T+
Sbjct: 226 DWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTR 285
Query: 328 RFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEED 382
R GN+KNG +D+K H+WF + DW A+ QRK++ P +PK G GDTSNF+ Y E D
Sbjct: 286 RLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPEND 340
>gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [Homo
sapiens]
Length = 671
Score = 280 bits (715), Expect = 2e-75
Identities = 140/303 (46%), Positives = 199/303 (65%), Gaps = 5/303 (1%)
Query: 85 NAGLEDFERKKTLGTGSFGRVMLVKHKATE-QYYAMKILDKQKVVKLKQIEHTLNEKRIL 143
N L DF TLG G FGRV LV+ K+ E + +AMKIL K+ +V +Q EH +EK+I+
Sbjct: 354 NLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM 413
Query: 144 QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 203
Q + F+VRL FKD+ LYM+ME GGE+++ LR G F + RFY A +V F
Sbjct: 414 QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFA 473
Query: 204 YLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRV--KGRTWTLCGTPEYLAPEIILSK 261
YLHS +IYRDLKPENL++DH+GY ++ DFGFAK++ +TWT CGTPEY+APEIIL+K
Sbjct: 474 YLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNK 533
Query: 262 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVRFPSHFSSDLKDLLRN 319
G++ + D+W+LG+L+YE+ G PPF P++ Y I+ G + FP + + +L++
Sbjct: 534 GHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKK 593
Query: 320 LLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYE 379
L + + ++R GNLKNGV DI+ HKWF +W + + + P IP DTSNFD +
Sbjct: 594 LCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFP 653
Query: 380 EED 382
E++
Sbjct: 654 EDN 656
>gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Homo
sapiens]
Length = 686
Score = 280 bits (715), Expect = 2e-75
Identities = 140/303 (46%), Positives = 199/303 (65%), Gaps = 5/303 (1%)
Query: 85 NAGLEDFERKKTLGTGSFGRVMLVKHKATE-QYYAMKILDKQKVVKLKQIEHTLNEKRIL 143
N L DF TLG G FGRV LV+ K+ E + +AMKIL K+ +V +Q EH +EK+I+
Sbjct: 369 NLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM 428
Query: 144 QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 203
Q + F+VRL FKD+ LYM+ME GGE+++ LR G F + RFY A +V F
Sbjct: 429 QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFA 488
Query: 204 YLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRV--KGRTWTLCGTPEYLAPEIILSK 261
YLHS +IYRDLKPENL++DH+GY ++ DFGFAK++ +TWT CGTPEY+APEIIL+K
Sbjct: 489 YLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNK 548
Query: 262 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVRFPSHFSSDLKDLLRN 319
G++ + D+W+LG+L+YE+ G PPF P++ Y I+ G + FP + + +L++
Sbjct: 549 GHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKK 608
Query: 320 LLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYE 379
L + + ++R GNLKNGV DI+ HKWF +W + + + P IP DTSNFD +
Sbjct: 609 LCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFP 668
Query: 380 EED 382
E++
Sbjct: 669 EDN 671
>gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]
Length = 762
Score = 278 bits (710), Expect = 8e-75
Identities = 159/377 (42%), Positives = 226/377 (59%), Gaps = 22/377 (5%)
Query: 10 NQYTGTTTALQK-LEGFASRLFHRHSKGTAHDQKTALENDSLHFSEHTALWDRSMKEFLA 68
NQ GT LQK LEG+ + L K A K ++ N L S+ +L +KE +A
Sbjct: 388 NQTVGTFEELQKYLEGYVANLNRDDEKRHA---KRSMSNWKL--SKALSLEMIQLKEKVA 442
Query: 69 KAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVV 128
+ +P QN E TLG G FGRV LVK K +AMK + K+ +V
Sbjct: 443 RFSSS------SPFQN------LEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIV 490
Query: 129 KLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSE 188
KQ EH +EKRIL+ + PF+V+L FKDN +YM++E GGE++S LR G F E
Sbjct: 491 DTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDE 550
Query: 189 PHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG--RTWTL 246
P ++F A + F+YLH L +IYRDLKPENL++D +GY+++ DFGFAK++ +TWT
Sbjct: 551 PTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTF 610
Query: 247 CGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVR 304
CGTPEY+APE+IL+KG++ +VD+W+LG+L+YE+ G PPF + Y I+ G K+
Sbjct: 611 CGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMD 670
Query: 305 FPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIP 364
FP + +DL+R L + + T+R GNLKNG++DIK H+W +W + R + +P
Sbjct: 671 FPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQR 730
Query: 365 KFRGSGDTSNFDDYEEE 381
+ +G D S FD Y E
Sbjct: 731 ELKGPIDHSYFDKYPPE 747
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 269 bits (687), Expect = 4e-72
Identities = 134/313 (42%), Positives = 202/313 (64%), Gaps = 7/313 (2%)
Query: 81 PTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNE 139
P+ N +A DF K +G GSFG+V+L +HKA E +YA+K+L K+ ++K K+ +H ++E
Sbjct: 87 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSE 146
Query: 140 KRIL-QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 198
+ +L + V PFLV L ++F+ LY V++Y+ GGE+F HL+R F EP ARFYAA+I
Sbjct: 147 RNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEI 206
Query: 199 VLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAP 255
YLHSL+++YRDLKPEN+L+D QG+I +TDFG K T T CGTPEYLAP
Sbjct: 207 ASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAP 266
Query: 256 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKD 315
E++ + Y++ VDWW LG ++YEM G PPF++ ++Y+ I++ ++ + ++ +
Sbjct: 267 EVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARH 326
Query: 316 LLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNF 375
LL LLQ D TKR G K+ +IK+H +F+ +W + +K+ PF P G D +F
Sbjct: 327 LLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 385
Query: 376 D-DYEEEDIRVSI 387
D ++ EE + SI
Sbjct: 386 DPEFTEEPVPNSI 398
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 269 bits (687), Expect = 4e-72
Identities = 134/313 (42%), Positives = 202/313 (64%), Gaps = 7/313 (2%)
Query: 81 PTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNE 139
P+ N +A DF K +G GSFG+V+L +HKA E +YA+K+L K+ ++K K+ +H ++E
Sbjct: 101 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSE 160
Query: 140 KRIL-QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 198
+ +L + V PFLV L ++F+ LY V++Y+ GGE+F HL+R F EP ARFYAA+I
Sbjct: 161 RNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEI 220
Query: 199 VLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAP 255
YLHSL+++YRDLKPEN+L+D QG+I +TDFG K T T CGTPEYLAP
Sbjct: 221 ASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAP 280
Query: 256 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKD 315
E++ + Y++ VDWW LG ++YEM G PPF++ ++Y+ I++ ++ + ++ +
Sbjct: 281 EVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARH 340
Query: 316 LLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNF 375
LL LLQ D TKR G K+ +IK+H +F+ +W + +K+ PF P G D +F
Sbjct: 341 LLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 399
Query: 376 D-DYEEEDIRVSI 387
D ++ EE + SI
Sbjct: 400 DPEFTEEPVPNSI 412
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 269 bits (687), Expect = 4e-72
Identities = 134/313 (42%), Positives = 202/313 (64%), Gaps = 7/313 (2%)
Query: 81 PTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNE 139
P+ N +A DF K +G GSFG+V+L +HKA E +YA+K+L K+ ++K K+ +H ++E
Sbjct: 115 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSE 174
Query: 140 KRIL-QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 198
+ +L + V PFLV L ++F+ LY V++Y+ GGE+F HL+R F EP ARFYAA+I
Sbjct: 175 RNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEI 234
Query: 199 VLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAP 255
YLHSL+++YRDLKPEN+L+D QG+I +TDFG K T T CGTPEYLAP
Sbjct: 235 ASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAP 294
Query: 256 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKD 315
E++ + Y++ VDWW LG ++YEM G PPF++ ++Y+ I++ ++ + ++ +
Sbjct: 295 EVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARH 354
Query: 316 LLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNF 375
LL LLQ D TKR G K+ +IK+H +F+ +W + +K+ PF P G D +F
Sbjct: 355 LLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 413
Query: 376 D-DYEEEDIRVSI 387
D ++ EE + SI
Sbjct: 414 DPEFTEEPVPNSI 426
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 269 bits (687), Expect = 4e-72
Identities = 134/313 (42%), Positives = 202/313 (64%), Gaps = 7/313 (2%)
Query: 81 PTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNE 139
P+ N +A DF K +G GSFG+V+L +HKA E +YA+K+L K+ ++K K+ +H ++E
Sbjct: 182 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSE 241
Query: 140 KRIL-QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 198
+ +L + V PFLV L ++F+ LY V++Y+ GGE+F HL+R F EP ARFYAA+I
Sbjct: 242 RNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEI 301
Query: 199 VLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAP 255
YLHSL+++YRDLKPEN+L+D QG+I +TDFG K T T CGTPEYLAP
Sbjct: 302 ASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAP 361
Query: 256 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKD 315
E++ + Y++ VDWW LG ++YEM G PPF++ ++Y+ I++ ++ + ++ +
Sbjct: 362 EVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARH 421
Query: 316 LLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNF 375
LL LLQ D TKR G K+ +IK+H +F+ +W + +K+ PF P G D +F
Sbjct: 422 LLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 480
Query: 376 D-DYEEEDIRVSI 387
D ++ EE + SI
Sbjct: 481 DPEFTEEPVPNSI 493
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 268 bits (685), Expect = 6e-72
Identities = 132/293 (45%), Positives = 186/293 (63%), Gaps = 3/293 (1%)
Query: 88 LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 147
+ DF+ K LG G+FG+V+LV+ KAT +YYAMKIL K+ ++ ++ HT+ E R+LQ
Sbjct: 149 MNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTR 208
Query: 148 FPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 207
PFL L+YAF+ + L VMEY GGE+F HL R F+E ARFY A+IV EYLHS
Sbjct: 209 HPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHS 268
Query: 208 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKR--VKGRTW-TLCGTPEYLAPEIILSKGYN 264
D++YRD+K ENL++D G+I++TDFG K G T T CGTPEYLAPE++ Y
Sbjct: 269 RDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYG 328
Query: 265 KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVD 324
+AVDWW LGV++YEM G PF+ +++E I+ ++RFP S + K LL LL+ D
Sbjct: 329 RAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKD 388
Query: 325 LTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDD 377
+R G + ++ H++F + +W + Q+K+ PF P+ DT FDD
Sbjct: 389 PKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDD 441
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 268 bits (684), Expect = 8e-72
Identities = 134/308 (43%), Positives = 188/308 (61%), Gaps = 4/308 (1%)
Query: 88 LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 147
+ DF+ K LG G+FG+V+LV+ KA+ +YYAMKIL K+ ++ ++ HTL E R+L+
Sbjct: 145 MNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTR 204
Query: 148 FPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 207
PFL L+Y+F+ L VMEYV GGE+F HL R FSE RFY A+IV +YLHS
Sbjct: 205 HPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHS 264
Query: 208 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKR---VKGRTWTLCGTPEYLAPEIILSKGYN 264
++YRDLK ENL++D G+I++TDFG K T CGTPEYLAPE++ Y
Sbjct: 265 GKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYG 324
Query: 265 KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVD 324
+AVDWW LGV++YEM G PF+ +++E I+ ++FP SSD K LL LL D
Sbjct: 325 RAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKD 384
Query: 325 LTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFD-DYEEEDI 383
KR G + +I H +F+ +W +Y +K+ PF P+ DT FD ++ + I
Sbjct: 385 PNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTI 444
Query: 384 RVSITEKC 391
++ EKC
Sbjct: 445 TITPPEKC 452
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 265 bits (678), Expect = 4e-71
Identities = 153/394 (38%), Positives = 213/394 (54%), Gaps = 22/394 (5%)
Query: 5 REPPCNQYTGTTTALQKLEG---------------FASRLFHRHSKGTAHDQKTALEN-- 47
RE P N ++ L K E R FH + + TA++
Sbjct: 48 REAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVA 107
Query: 48 DSLHFSEHTALWDRSMKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML 107
D L E + RS E+ P ++ + +FE K LG G+FG+V+L
Sbjct: 108 DGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKP-KHRVTMNEFEYLKLLGKGTFGKVIL 166
Query: 108 VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV 167
VK KAT +YYAMKIL K+ +V ++ HTL E R+LQ PFL L+Y+F+ + L V
Sbjct: 167 VKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFV 226
Query: 168 MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS-LDLIYRDLKPENLLIDHQG 226
MEY GGE+F HL R FSE ARFY A+IV +YLHS +++YRDLK ENL++D G
Sbjct: 227 MEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDG 286
Query: 227 YIQVTDFGFAKR--VKGRTW-TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGY 283
+I++TDFG K G T T CGTPEYLAPE++ Y +AVDWW LGV++YEM G
Sbjct: 287 HIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGR 346
Query: 284 PPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHK 343
PF+ +++E I+ ++RFP + K LL LL+ D +R G +I H+
Sbjct: 347 LPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHR 406
Query: 344 WFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDD 377
+FA W +Y++K+ PF P+ DT FD+
Sbjct: 407 FFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 265 bits (678), Expect = 4e-71
Identities = 153/394 (38%), Positives = 213/394 (54%), Gaps = 22/394 (5%)
Query: 5 REPPCNQYTGTTTALQKLEG---------------FASRLFHRHSKGTAHDQKTALEN-- 47
RE P N ++ L K E R FH + + TA++
Sbjct: 48 REAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVA 107
Query: 48 DSLHFSEHTALWDRSMKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML 107
D L E + RS E+ P ++ + +FE K LG G+FG+V+L
Sbjct: 108 DGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKP-KHRVTMNEFEYLKLLGKGTFGKVIL 166
Query: 108 VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV 167
VK KAT +YYAMKIL K+ +V ++ HTL E R+LQ PFL L+Y+F+ + L V
Sbjct: 167 VKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFV 226
Query: 168 MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS-LDLIYRDLKPENLLIDHQG 226
MEY GGE+F HL R FSE ARFY A+IV +YLHS +++YRDLK ENL++D G
Sbjct: 227 MEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDG 286
Query: 227 YIQVTDFGFAKR--VKGRTW-TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGY 283
+I++TDFG K G T T CGTPEYLAPE++ Y +AVDWW LGV++YEM G
Sbjct: 287 HIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGR 346
Query: 284 PPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHK 343
PF+ +++E I+ ++RFP + K LL LL+ D +R G +I H+
Sbjct: 347 LPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHR 406
Query: 344 WFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDD 377
+FA W +Y++K+ PF P+ DT FD+
Sbjct: 407 FFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 265 bits (678), Expect = 4e-71
Identities = 153/394 (38%), Positives = 213/394 (54%), Gaps = 22/394 (5%)
Query: 5 REPPCNQYTGTTTALQKLEG---------------FASRLFHRHSKGTAHDQKTALEN-- 47
RE P N ++ L K E R FH + + TA++
Sbjct: 48 REAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVA 107
Query: 48 DSLHFSEHTALWDRSMKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML 107
D L E + RS E+ P ++ + +FE K LG G+FG+V+L
Sbjct: 108 DGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKP-KHRVTMNEFEYLKLLGKGTFGKVIL 166
Query: 108 VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV 167
VK KAT +YYAMKIL K+ +V ++ HTL E R+LQ PFL L+Y+F+ + L V
Sbjct: 167 VKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFV 226
Query: 168 MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS-LDLIYRDLKPENLLIDHQG 226
MEY GGE+F HL R FSE ARFY A+IV +YLHS +++YRDLK ENL++D G
Sbjct: 227 MEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDG 286
Query: 227 YIQVTDFGFAKR--VKGRTW-TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGY 283
+I++TDFG K G T T CGTPEYLAPE++ Y +AVDWW LGV++YEM G
Sbjct: 287 HIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGR 346
Query: 284 PPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHK 343
PF+ +++E I+ ++RFP + K LL LL+ D +R G +I H+
Sbjct: 347 LPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHR 406
Query: 344 WFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDD 377
+FA W +Y++K+ PF P+ DT FD+
Sbjct: 407 FFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 264 bits (675), Expect = 9e-71
Identities = 133/307 (43%), Positives = 187/307 (60%), Gaps = 4/307 (1%)
Query: 88 LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 147
+ DF+ K LG G+FG+V+LV+ KA+ +YYAMKIL K+ ++ ++ HTL E R+L+
Sbjct: 145 MNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTR 204
Query: 148 FPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 207
PFL L+Y+F+ L VMEYV GGE+F HL R FSE RFY A+IV +YLHS
Sbjct: 205 HPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHS 264
Query: 208 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKR---VKGRTWTLCGTPEYLAPEIILSKGYN 264
++YRDLK ENL++D G+I++TDFG K T CGTPEYLAPE++ Y
Sbjct: 265 GKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYG 324
Query: 265 KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVD 324
+AVDWW LGV++YEM G PF+ +++E I+ ++FP SSD K LL LL D
Sbjct: 325 RAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKD 384
Query: 325 LTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFD-DYEEEDI 383
KR G + +I H +F+ +W +Y +K+ PF P+ DT FD ++ + I
Sbjct: 385 PNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTI 444
Query: 384 RVSITEK 390
++ EK
Sbjct: 445 TITPPEK 451
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 264 bits (674), Expect = 1e-70
Identities = 134/313 (42%), Positives = 200/313 (63%), Gaps = 7/313 (2%)
Query: 81 PTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNE 139
P+ N NA DF+ K +G G++G+V+L K K+ +YA+K+L K+ ++K K+ H + E
Sbjct: 24 PSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAE 83
Query: 140 KRIL-QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 198
+ +L + V PFLV L Y+F+ LY V++YV GGE+F HL+R RF EP ARFYAA++
Sbjct: 84 RSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEV 143
Query: 199 VLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAP 255
YLHSL++IYRDLKPEN+L+D QG++ +TDFG K + T T CGTPEYLAP
Sbjct: 144 ASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAP 203
Query: 256 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKD 315
E++ + Y++AVDWW LG ++YEM G PPF++ Q+YE I+ ++ P + D
Sbjct: 204 EVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACD 263
Query: 316 LLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNF 375
LL++LL D +R G+ K +IK H +F+ +W +Y +++ PF P G D +F
Sbjct: 264 LLQSLLHKDQRQRLGS-KADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHF 322
Query: 376 D-DYEEEDIRVSI 387
D ++ +E + SI
Sbjct: 323 DPEFTQEAVSKSI 335
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 264 bits (674), Expect = 1e-70
Identities = 134/313 (42%), Positives = 200/313 (63%), Gaps = 7/313 (2%)
Query: 81 PTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNE 139
P+ N NA DF+ K +G G++G+V+L K K+ +YA+K+L K+ ++K K+ H + E
Sbjct: 84 PSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAE 143
Query: 140 KRIL-QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 198
+ +L + V PFLV L Y+F+ LY V++YV GGE+F HL+R RF EP ARFYAA++
Sbjct: 144 RSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEV 203
Query: 199 VLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAP 255
YLHSL++IYRDLKPEN+L+D QG++ +TDFG K + T T CGTPEYLAP
Sbjct: 204 ASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAP 263
Query: 256 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKD 315
E++ + Y++AVDWW LG ++YEM G PPF++ Q+YE I+ ++ P + D
Sbjct: 264 EVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACD 323
Query: 316 LLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNF 375
LL++LL D +R G+ K +IK H +F+ +W +Y +++ PF P G D +F
Sbjct: 324 LLQSLLHKDQRQRLGS-KADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHF 382
Query: 376 D-DYEEEDIRVSI 387
D ++ +E + SI
Sbjct: 383 DPEFTQEAVSKSI 395
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 254 bits (649), Expect = 1e-67
Identities = 127/296 (42%), Positives = 182/296 (61%), Gaps = 7/296 (2%)
Query: 88 LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 147
L+DF LG G FG+V+L ++K T + +A+K L K +V +++ + EKRI + VN
Sbjct: 654 LQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVN 713
Query: 148 ---FPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEY 204
PFLV L F+ ++ VMEY GG++ H+ FSEP A FYAA +VL +Y
Sbjct: 714 SVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT-DVFSEPRAVFYAACVVLGLQY 772
Query: 205 LHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILSK 261
LH ++YRDLK +NLL+D +G++++ DFG K G RT T CGTPE+LAPE++
Sbjct: 773 LHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTET 832
Query: 262 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLL 321
Y +AVDWW LGVLIYEM G PF D ++++ IV+ +VR+P S++ ++R LL
Sbjct: 833 SYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLL 892
Query: 322 QVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDD 377
+ + +R G + D+K H +F DW A+ +KV+ PFIP RG D SNFDD
Sbjct: 893 RRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDD 948
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 249 bits (637), Expect = 2e-66
Identities = 128/316 (40%), Positives = 191/316 (60%), Gaps = 5/316 (1%)
Query: 80 NPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNE 139
N ++ L DF LG GSFG+VML + K T++ YA+KIL K V++ +E T+ E
Sbjct: 331 NGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVE 390
Query: 140 KRILQAVNFP-FLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 198
KR+L P FL +L F+ LY VMEYV GG++ H++++GRF EPHA FYAA+I
Sbjct: 391 KRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI 450
Query: 199 VLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAP 255
+ +L S +IYRDLK +N+++D +G+I++ DFG K T T CGTP+Y+AP
Sbjct: 451 AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAP 510
Query: 256 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKD 315
EII + Y K+VDWWA GVL+YEM AG PF + ++++ I+ V +P S +
Sbjct: 511 EIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVA 570
Query: 316 LLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNF 375
+ + L+ KR G G DIK H +F DW + +++++ P+ PK R DTSNF
Sbjct: 571 ICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNF 630
Query: 376 D-DYEEEDIRVSITEK 390
D ++ + + ++ T+K
Sbjct: 631 DKEFTRQPVELTPTDK 646
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 245 bits (626), Expect = 4e-65
Identities = 124/303 (40%), Positives = 180/303 (59%), Gaps = 6/303 (1%)
Query: 90 DFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRIL-QAVNF 148
DF+ K +G GSFG+V+L K K ++YA+K+L K+ V+ K+ +H + E+ +L + V
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
Query: 149 PFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 208
PFLV L Y+F+ LY V+++V GGE+F HL+R F E ARFYAA+I YLHS+
Sbjct: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
Query: 209 DLIYRDLKPENLLIDHQGYIQVTDFGFAKR---VKGRTWTLCGTPEYLAPEIILSKGYNK 265
++YRDLKPEN+L+D G++ +TDFG K + T T CGTPEYLAPE+I + Y+
Sbjct: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN 340
Query: 266 AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDL 325
VDWW LG ++YEM G PPF+ ++Y+ I+ + S +L LL+ D
Sbjct: 341 TVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDR 400
Query: 326 TKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDD-YEEEDIR 384
R G K +I+ H +F + W + Q+K+ PF P G D NFD + EE +
Sbjct: 401 QNRLG-AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVP 459
Query: 385 VSI 387
S+
Sbjct: 460 YSV 462
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 245 bits (626), Expect = 4e-65
Identities = 124/303 (40%), Positives = 180/303 (59%), Gaps = 6/303 (1%)
Query: 90 DFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRIL-QAVNF 148
DF+ K +G GSFG+V+L K K ++YA+K+L K+ V+ K+ +H + E+ +L + V
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
Query: 149 PFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 208
PFLV L Y+F+ LY V+++V GGE+F HL+R F E ARFYAA+I YLHS+
Sbjct: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
Query: 209 DLIYRDLKPENLLIDHQGYIQVTDFGFAKR---VKGRTWTLCGTPEYLAPEIILSKGYNK 265
++YRDLKPEN+L+D G++ +TDFG K + T T CGTPEYLAPE+I + Y+
Sbjct: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN 340
Query: 266 AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDL 325
VDWW LG ++YEM G PPF+ ++Y+ I+ + S +L LL+ D
Sbjct: 341 TVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDR 400
Query: 326 TKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDD-YEEEDIR 384
R G K +I+ H +F + W + Q+K+ PF P G D NFD + EE +
Sbjct: 401 QNRLG-AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVP 459
Query: 385 VSI 387
S+
Sbjct: 460 YSV 462
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 245 bits (625), Expect = 6e-65
Identities = 128/315 (40%), Positives = 191/315 (60%), Gaps = 7/315 (2%)
Query: 82 TQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKR 141
+ N G+++FE + LG GSFG+VML + K T YA+K+L K +++ +E T+ EKR
Sbjct: 346 SSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKR 405
Query: 142 ILQ-AVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVL 200
IL A N PFL +L F+ L+ VME+V GG++ H+++ RF E ARFYAA+I+
Sbjct: 406 ILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIIS 465
Query: 201 TFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKR--VKG-RTWTLCGTPEYLAPEI 257
+LH +IYRDLK +N+L+DH+G+ ++ DFG K G T T CGTP+Y+APEI
Sbjct: 466 ALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEI 525
Query: 258 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLL 317
+ Y AVDWWA+GVL+YEM G+ PF A+ ++E I++ +V +P+ D +L
Sbjct: 526 LQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGIL 585
Query: 318 RNLLQVDLTKRFGNL-KNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFD 376
++ + + T R G+L + G I H +F DW + R++E PF P+ + D SNFD
Sbjct: 586 KSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFD 645
Query: 377 D--YEEEDIRVSITE 389
+EE + I E
Sbjct: 646 PDFIKEEPVLTPIDE 660
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 244 bits (623), Expect = 1e-64
Identities = 124/295 (42%), Positives = 180/295 (61%), Gaps = 5/295 (1%)
Query: 88 LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 147
L DF LG GSFG+VML K TE+ YA+KIL K V++ +E T+ EKR+L ++
Sbjct: 336 LTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLD 395
Query: 148 FP-FLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 206
P FL +L F+ LY VMEYV GG++ H++++G+F EP A FYAA+I + +LH
Sbjct: 396 KPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLH 455
Query: 207 SLDLIYRDLKPENLLIDHQGYIQVTDFGFAKR--VKG-RTWTLCGTPEYLAPEIILSKGY 263
+IYRDLK +N+++D +G+I++ DFG K + G T T CGTP+Y+APEII + Y
Sbjct: 456 KRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPY 515
Query: 264 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 323
K+VDWWA GVL+YEM AG PPF + ++++ I+ V +P S + + + L+
Sbjct: 516 GKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTK 575
Query: 324 DLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDY 378
KR G G D++ H +F DW + R+++ PF PK G G NFD +
Sbjct: 576 HPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKG-AENFDKF 629
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 241 bits (615), Expect = 8e-64
Identities = 125/319 (39%), Positives = 190/319 (59%), Gaps = 8/319 (2%)
Query: 87 GLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQ-A 145
GL++F K LG GSFG+VML + K ++ YA+K+L K +++ ++ T+ EKRIL A
Sbjct: 404 GLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALA 463
Query: 146 VNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 205
P+L +L F+ L+ VMEYV GG++ ++R +F EP +RFYAA++ +L
Sbjct: 464 RKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFL 523
Query: 206 HSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKR--VKG-RTWTLCGTPEYLAPEIILSKG 262
H +IYRDLK +N+L+D +G+ ++ DFG K + G T T CGTP+Y+APEI+
Sbjct: 524 HQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELE 583
Query: 263 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQ 322
Y +VDWWALGVL+YEM AG PPF AD ++E I+ V +P S + +L+ +
Sbjct: 584 YGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMT 643
Query: 323 VDLTKRFGNL--KNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDD--Y 378
+ KR G + +NG IK H +F DW+ + Q+K++ PF P+ + D +NFD
Sbjct: 644 KNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFT 703
Query: 379 EEEDIRVSITEKCAKEFGE 397
EE + + E K+ +
Sbjct: 704 REEPVLTLVDEAIVKQINQ 722
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
Length = 766
Score = 239 bits (610), Expect = 3e-63
Identities = 129/307 (42%), Positives = 186/307 (60%), Gaps = 14/307 (4%)
Query: 83 QNNAGLEDFERKKTLGTGSFGRVMLVKHKATE---QYYAMKILDKQKVV-KLKQIEHTLN 138
+ +E+FE K LGTG++G+V LV+ + YAMK+L K +V + K EHT
Sbjct: 25 EEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRT 84
Query: 139 EKRILQAVN-FPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQ 197
E+ +L+ V PFLV L YAF+ ++ L+++++YV GGEMF+HL + F E R Y +
Sbjct: 85 ERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGE 144
Query: 198 IVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRV----KGRTWTLCGTPEYL 253
IVL E+LH L +IYRDLK EN+L+D +G+I +TDFG +K K RT++ CGT EY+
Sbjct: 145 IVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYM 204
Query: 254 APEIILSK-GYNKAVDWWALGVLIYEMAAGYPPFFAD----QPIQIYEKIVSGKVRFPSH 308
APEII SK G+ KAVDWW+LG+L++E+ G PF + ++ +I+ FP
Sbjct: 205 APEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPR 264
Query: 309 FSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRG 368
+DLL+ LL D KR G G +++ H +F DW+A+ RK+ APF P+ R
Sbjct: 265 IGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRS 324
Query: 369 SGDTSNF 375
D NF
Sbjct: 325 ELDVGNF 331
Score = 114 bits (284), Expect = 2e-25
Identities = 82/256 (32%), Positives = 132/256 (51%), Gaps = 26/256 (10%)
Query: 93 RKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLV 152
R+ LG GSF + + + Q +A+KIL ++ ++ L R+ Q+ P +V
Sbjct: 407 REPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAAL---RLCQS--HPNVV 461
Query: 153 RLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS-LDLI 211
L D + Y+V+E + GGE+ H+R+ FSE A +V ++H ++
Sbjct: 462 NLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVV 521
Query: 212 YRDLKPENLLI--DHQGY-IQVTDFGFAKRVKGRT-----WTLCGTPEYLAPEIILSKGY 263
+RDLKPEN+L D G +++ DFGFA R++ ++ T C T +Y APE++ +GY
Sbjct: 522 HRDLKPENILYADDTPGAPVKIIDFGFA-RLRPQSPGVPMQTPCFTLQYAAPELLAQQGY 580
Query: 264 NKAVDWWALGVLIYEMAAGYPPFFA-------DQPIQIYEKIVSGKVRFPSH----FSSD 312
+++ D W+LGV++Y M +G PF Q +I KI G+ S +
Sbjct: 581 DESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEE 640
Query: 313 LKDLLRNLLQVDLTKR 328
K+L+R LL VD KR
Sbjct: 641 AKELVRGLLTVDPAKR 656
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,125,053
Number of Sequences: 37866
Number of extensions: 648993
Number of successful extensions: 3627
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 708
Number of HSP's successfully gapped in prelim test: 85
Number of HSP's that attempted gapping in prelim test: 1314
Number of HSP's gapped (non-prelim): 895
length of query: 398
length of database: 18,247,518
effective HSP length: 104
effective length of query: 294
effective length of database: 14,309,454
effective search space: 4206979476
effective search space used: 4206979476
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.