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Search of human proteins with 28416444
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2
precursor [Homo sapiens]
(905 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2 ... 1825 0.0
gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1 p... 1719 0.0
gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1 ... 1438 0.0
gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2 ... 1417 0.0
gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor ... 1358 0.0
gi|29029597 glutamate receptor KA2 precursor [Homo sapiens] 706 0.0
gi|29029595 glutamate receptor KA1 precursor [Homo sapiens] 669 0.0
gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [H... 614 e-175
gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [H... 613 e-175
gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1 p... 600 e-171
gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2 p... 599 e-171
gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1 pre... 593 e-169
gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2 pr... 592 e-169
gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [H... 592 e-169
gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2 p... 588 e-168
gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1 p... 588 e-168
gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [H... 373 e-103
gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens] 366 e-101
gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens] 265 1e-70
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens] 260 5e-69
gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens] 260 5e-69
gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor ... 190 6e-48
gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2 ... 186 1e-46
gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1 ... 186 1e-46
gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1 pr... 186 1e-46
gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor ... 179 1e-44
gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor [... 171 3e-42
gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartat... 162 2e-39
gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate... 153 6e-37
gi|116284390 glutamate receptor, ionotrophic, AMPA 4 isoform 3 p... 145 2e-34
>gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2
precursor [Homo sapiens]
Length = 905
Score = 1825 bits (4727), Expect = 0.0
Identities = 905/905 (100%), Positives = 905/905 (100%)
Query: 1 MEHGTLLAQPGLWTRDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKF 60
MEHGTLLAQPGLWTRDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKF
Sbjct: 1 MEHGTLLAQPGLWTRDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKF 60
Query: 61 AVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQ 120
AVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQ
Sbjct: 61 AVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQ 120
Query: 121 SICNALEVPHIQTRWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDS 180
SICNALEVPHIQTRWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDS
Sbjct: 121 SICNALEVPHIQTRWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDS 180
Query: 181 TGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEIL 240
TGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEIL
Sbjct: 181 TGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEIL 240
Query: 241 KQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSME 300
KQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSME
Sbjct: 241 KQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSME 300
Query: 301 RLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRF 360
RLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRF
Sbjct: 301 RLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRF 360
Query: 361 MNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNKD 420
MNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNKD
Sbjct: 361 MNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNKD 420
Query: 421 KSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYD 480
KSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYD
Sbjct: 421 KSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYD 480
Query: 481 VKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISI 540
VKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISI
Sbjct: 481 VKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISI 540
Query: 541 LYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSD 600
LYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSD
Sbjct: 541 LYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSD 600
Query: 601 VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT 660
VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT
Sbjct: 601 VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT 660
Query: 661 VERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRN 720
VERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRN
Sbjct: 661 VERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRN 720
Query: 721 SDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITI 780
SDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITI
Sbjct: 721 SDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITI 780
Query: 781 AILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIG 840
AILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIG
Sbjct: 781 AILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIG 840
Query: 841 EFIYKSRKNNDIEQCLSFNAIMEELGISLKNQKKIKKKSRTKGKSSFTSILTCHQRRTQR 900
EFIYKSRKNNDIEQCLSFNAIMEELGISLKNQKKIKKKSRTKGKSSFTSILTCHQRRTQR
Sbjct: 841 EFIYKSRKNNDIEQCLSFNAIMEELGISLKNQKKIKKKSRTKGKSSFTSILTCHQRRTQR 900
Query: 901 KETVA 905
KETVA
Sbjct: 901 KETVA 905
>gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1
precursor [Homo sapiens]
Length = 918
Score = 1719 bits (4451), Expect = 0.0
Identities = 855/873 (97%), Positives = 855/873 (97%), Gaps = 15/873 (1%)
Query: 1 MEHGTLLAQPGLWTRDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKF 60
MEHGTLLAQPGLWTRDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKF
Sbjct: 1 MEHGTLLAQPGLWTRDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKF 60
Query: 61 AVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQ 120
AVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQ
Sbjct: 61 AVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQ 120
Query: 121 SICNALEVPHIQTRWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDS 180
SICNALEVPHIQTRWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDS
Sbjct: 121 SICNALEVPHIQTRWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDS 180
Query: 181 TGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEIL 240
TGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEIL
Sbjct: 181 TGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEIL 240
Query: 241 KQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSME 300
KQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSME
Sbjct: 241 KQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSME 300
Query: 301 RLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRF 360
RLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRF
Sbjct: 301 RLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRF 360
Query: 361 MNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEK---------------IGI 405
MNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEK IGI
Sbjct: 361 MNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGI 420
Query: 406 WNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCL 465
WNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCL
Sbjct: 421 WNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCL 480
Query: 466 DLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREK 525
DLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREK
Sbjct: 481 DLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREK 540
Query: 526 VIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFT 585
VIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFT
Sbjct: 541 VIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFT 600
Query: 586 PYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTL 645
PYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTL
Sbjct: 601 PYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTL 660
Query: 646 IIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKM 705
IIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKM
Sbjct: 661 IIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKM 720
Query: 706 WAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYG 765
WAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYG
Sbjct: 721 WAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYG 780
Query: 766 VGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFI 825
VGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFI
Sbjct: 781 VGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFI 840
Query: 826 VLAAGLVLSVFVAIGEFIYKSRKNNDIEQCLSF 858
VLAAGLVLSVFVAIGEFIYKSRKNNDIEQ F
Sbjct: 841 VLAAGLVLSVFVAIGEFIYKSRKNNDIEQAFCF 873
>gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1
precursor [Homo sapiens]
Length = 908
Score = 1438 bits (3722), Expect = 0.0
Identities = 705/895 (78%), Positives = 799/895 (89%), Gaps = 4/895 (0%)
Query: 15 RDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPN 74
R T LL L Q VLR GGIFE VE+ P+ EELAF+FAV +INRNRTL+PN
Sbjct: 14 RRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPN 73
Query: 75 TTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTR 134
TTLTYD Q+INL+DSFEAS++ACDQL+LGVAA+FGPSHSSS +AVQSICNAL VPHIQTR
Sbjct: 74 TTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTR 133
Query: 135 WKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPS 194
WKH DNKD FY++LYPD++++SRAILDLV ++ WKTVTVVY+DSTGLIRLQELIKAPS
Sbjct: 134 WKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPS 193
Query: 195 RYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYH 254
RYN+++KIRQLP+ KDAKPLLKEMK+GKEF+VIFDCSHE AA ILKQ L MGMMTEYYH
Sbjct: 194 RYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYH 253
Query: 255 YFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLD 314
Y FTTLDLFALD+E YRYSGVNMTGFR+LN +N VSSIIEKWSMERLQAPP+P++GLLD
Sbjct: 254 YIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLD 313
Query: 315 GMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTG 374
G MTT+AALMYDAV++V++A + Q+TVSSLQC+RHKPWR G RFM+LIKEA W+GLTG
Sbjct: 314 GFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTG 373
Query: 375 HITFNKTNGLRKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTL 434
ITFNKTNGLR DFDLD+ISLKEEG EKIG W+ SGLNMT+S K K +NITDSL+NR+L
Sbjct: 374 RITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSL 433
Query: 435 IVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQND 494
IVTTILEEPYV+++KSDKPLYGNDRFEGYC+DLL+ELS ILGF Y+++LV DGKYGAQ+D
Sbjct: 434 IVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDD 493
Query: 495 -KGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVF 553
G+WNGMV+ELIDH+ADLAVAPL ITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVF
Sbjct: 494 ANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVF 553
Query: 554 SFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFW 613
SFLNPLSPDIWMY+LLA LGVSCVLFVIARF+PYEWYNPHPCNPDSDVVENNFTLLNSFW
Sbjct: 554 SFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFW 613
Query: 614 FGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD 673
FGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD
Sbjct: 614 FGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD 673
Query: 674 LAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDY 733
LAKQTKIEYGAV DG+TMTFFKKSKISTY+KMWAFMSSR+Q+ LV++++EGIQRVLT+DY
Sbjct: 674 LAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDY 733
Query: 734 ALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHM 793
A LMEST+IE+VTQRNCNLTQIGGLIDSKGYGVGTP+GSPYRDKITIAILQLQEEGKLHM
Sbjct: 734 AFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHM 793
Query: 794 MKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIE 853
MKEKWWRGNGCPEE++KEASALGV+NIGGIFIVLAAGLVLSVFVA+GEF+YKS+KN +E
Sbjct: 794 MKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLE 853
Query: 854 QCLSFNAIMEELGISLKNQKKIKKKSRTKGKSSFTSILTCH---QRRTQRKETVA 905
+ +A++EEL +SLK Q+++K K + ++ H RR KET+A
Sbjct: 854 KRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA 908
>gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2
precursor [Homo sapiens]
Length = 869
Score = 1417 bits (3669), Expect = 0.0
Identities = 688/841 (81%), Positives = 771/841 (91%), Gaps = 1/841 (0%)
Query: 15 RDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPN 74
R T LL L Q VLR GGIFE VE+ P+ EELAF+FAV +INRNRTL+PN
Sbjct: 14 RRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPN 73
Query: 75 TTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTR 134
TTLTYD Q+INL+DSFEAS++ACDQL+LGVAA+FGPSHSSS +AVQSICNAL VPHIQTR
Sbjct: 74 TTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTR 133
Query: 135 WKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPS 194
WKH DNKD FY++LYPD++++SRAILDLV ++ WKTVTVVY+DSTGLIRLQELIKAPS
Sbjct: 134 WKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPS 193
Query: 195 RYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYH 254
RYN+++KIRQLP+ KDAKPLLKEMK+GKEF+VIFDCSHE AA ILKQ L MGMMTEYYH
Sbjct: 194 RYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYH 253
Query: 255 YFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLD 314
Y FTTLDLFALD+E YRYSGVNMTGFR+LN +N VSSIIEKWSMERLQAPP+P++GLLD
Sbjct: 254 YIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLD 313
Query: 315 GMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTG 374
G MTT+AALMYDAV++V++A + Q+TVSSLQC+RHKPWR G RFM+LIKEA W+GLTG
Sbjct: 314 GFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTG 373
Query: 375 HITFNKTNGLRKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTL 434
ITFNKTNGLR DFDLD+ISLKEEG EKIG W+ SGLNMT+S K K +NITDSL+NR+L
Sbjct: 374 RITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSL 433
Query: 435 IVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQND 494
IVTTILEEPYV+++KSDKPLYGNDRFEGYC+DLL+ELS ILGF Y+++LV DGKYGAQ+D
Sbjct: 434 IVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDD 493
Query: 495 -KGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVF 553
G+WNGMV+ELIDH+ADLAVAPL ITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVF
Sbjct: 494 ANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVF 553
Query: 554 SFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFW 613
SFLNPLSPDIWMY+LLA LGVSCVLFVIARF+PYEWYNPHPCNPDSDVVENNFTLLNSFW
Sbjct: 554 SFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFW 613
Query: 614 FGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD 673
FGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD
Sbjct: 614 FGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD 673
Query: 674 LAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDY 733
LAKQTKIEYGAV DG+TMTFFKKSKISTY+KMWAFMSSR+Q+ LV++++EGIQRVLT+DY
Sbjct: 674 LAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDY 733
Query: 734 ALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHM 793
A LMEST+IE+VTQRNCNLTQIGGLIDSKGYGVGTP+GSPYRDKITIAILQLQEEGKLHM
Sbjct: 734 AFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHM 793
Query: 794 MKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIE 853
MKEKWWRGNGCPEE++KEASALGV+NIGGIFIVLAAGLVLSVFVA+GEF+YKS+KN +E
Sbjct: 794 MKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLE 853
Query: 854 Q 854
+
Sbjct: 854 K 854
>gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor
[Homo sapiens]
Length = 919
Score = 1358 bits (3516), Expect = 0.0
Identities = 657/895 (73%), Positives = 773/895 (86%), Gaps = 9/895 (1%)
Query: 19 WALLYFLCYILPQTA--PQVLRIGGIFETVEN---EPVNVEELAFKFAVTSINRNRTLMP 73
WA L + +P + P V+RIGGIFE + + +N EE AF+F+ INRNRTL+P
Sbjct: 16 WAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLP 75
Query: 74 NTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQT 133
NTTLTYDIQRI+ DSFEA+++ACDQLALGV A+FGPS S +AVQSICNALEVPHIQ
Sbjct: 76 NTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQL 135
Query: 134 RWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAP 193
RWKH +DNKD FY+NLYPDYA++S AILDLV Y W++ TVVY+DSTGLIRLQELI AP
Sbjct: 136 RWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAP 195
Query: 194 SRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYY 253
SRYNI++KIRQLP + D++PLLKEMK+G+EF +IFDCSH AA+ILKQ + MGMMTEYY
Sbjct: 196 SRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYY 255
Query: 254 HYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLL 313
H+ FTTLDL+ALDLE YRYSGVN+TGFR+LN+DNPHVS+I+EKWSMERLQA PR E+GLL
Sbjct: 256 HFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLL 315
Query: 314 DGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLT 373
DG+M T+AAL+YDAV++V++ RA Q+TV+SLQCHRHK WR G RFMN IKEA+W+GLT
Sbjct: 316 DGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLT 375
Query: 374 GHITFNKTNGLRKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNKDKSSNITDSLANRT 433
G I FNKT+GLR DFDLDIISLKE+G EK+G+W+ GLN+T+ K + N+TDSL NR+
Sbjct: 376 GRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRS 435
Query: 434 LIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQN 493
LIVTT+LEEP+VM+RKSD+ LYGNDRFEGYC+DLLKEL++ILGF Y+++LV DGKYGAQ+
Sbjct: 436 LIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQD 495
Query: 494 DKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVF 553
DKG+WNGMVKELIDH+ADLAVAPLTIT+VREK IDFSKPFMTLG+SILYRKPNGTNP VF
Sbjct: 496 DKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVF 555
Query: 554 SFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFW 613
SFLNPLSPDIWMYVLLA LGVSCVLFVIARF+PYEWY+ HPCNP S+VVENNFTLLNSFW
Sbjct: 556 SFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFW 615
Query: 614 FGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD 673
FG+G+LMQQGSELMPKALSTRI+GGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD
Sbjct: 616 FGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD 675
Query: 674 LAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDY 733
LAKQTKIEYGAV+DG+TMTFFKKSKIST+EKMWAFMSS+ +ALV+N++EGIQR LT DY
Sbjct: 676 LAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSK-PSALVKNNEEGIQRALTADY 734
Query: 734 ALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHM 793
ALLMEST+IEYVTQRNCNLTQIGGLIDSKGYG+GTP+GSPYRDKITIAILQLQEE KLH+
Sbjct: 735 ALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHI 794
Query: 794 MKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIE 853
MKEKWWRG+GCPEE+NKEASALG++ IGGIFIVLAAGLVLSV VA+GEF+YK RK + E
Sbjct: 795 MKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAERE 854
Query: 854 QCLSFNAIMEELGISLKNQKKIKKKSRTKGKSSFTSILTCH---QRRTQRKETVA 905
Q + + +E+ SL Q+++K K + +++ H RR K+++A
Sbjct: 855 QRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMA 909
>gi|29029597 glutamate receptor KA2 precursor [Homo sapiens]
Length = 980
Score = 706 bits (1823), Expect = 0.0
Identities = 378/843 (44%), Positives = 530/843 (62%), Gaps = 22/843 (2%)
Query: 54 EELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHS 113
E LA A IN + + DI + +E + C L GV ++ GPS S
Sbjct: 40 ERLALALAREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSS 99
Query: 114 -SSVSAVQSICNALEVPHIQTRWKH-PSVDNKDLFYINLYPDYAAISRAILDLVLYYNWK 171
+S S V IC E+PHI+ + P + ++LYP +S A+ ++ +N+
Sbjct: 100 PASASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYP 159
Query: 172 TVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDC 231
+ +++ + L+RL+EL++ + +R L ++D PLLKE++ K +I D
Sbjct: 160 SASLICAKAECLLRLEELVRGFLISKETLSVRMLDD-SRDPTPLLKEIRDDKVSTIIIDA 218
Query: 232 SHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVS 291
+ + IL++ +GM + +Y Y TT+D L L+ N+ GF + N +P
Sbjct: 219 NASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYP 278
Query: 292 SIIEKWSM---ERLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIAS---HRASQLTVSS 345
+ +M E +A L AALM+DAV++V A +R+ ++ V
Sbjct: 279 EFVRSLNMSWRENCEASTYLGPAL-------SAALMFDAVHVVVSAVRELNRSQEIGVKP 331
Query: 346 LQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKIGI 405
L C W G MN ++ +DGLTG + FN + G R ++ L I+ +G +IG+
Sbjct: 332 LACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFN-SKGQRTNYTLRILEKSRQGHREIGV 390
Query: 406 WNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCL 465
W SN L M + D N++ +LAN+TL+VTTILE PYVM R + + L GN+RFEG+C+
Sbjct: 391 WYSNRTLAMNATTLD--INLSQTLANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCV 448
Query: 466 DLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREK 525
D+L+EL+ +L F Y ++LV DG YGA G W GMV ELI+ +ADLAVA TIT REK
Sbjct: 449 DMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTITAEREK 508
Query: 526 VIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFT 585
VIDFSKPFMTLGISILYR G PG FSFL+P SP +W+++LLA L VSCVLF+ AR +
Sbjct: 509 VIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLS 568
Query: 586 PYEWYNPHPC-NPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFT 644
PYEWYNPHPC ++EN +TL NS WF VG MQQGSE+MP+ALSTR V G+WW FT
Sbjct: 569 PYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFT 628
Query: 645 LIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEK 704
LIIISSYTANLAAFLTV+RME P++SADDLA QT IEYG + GSTMTFF+ S+ TY++
Sbjct: 629 LIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQR 688
Query: 705 MWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGY 764
MW +M S+Q + V++++EGI RVL + YA L+EST EY + NCNLTQIGGL+D+KGY
Sbjct: 689 MWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGY 748
Query: 765 GVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIF 824
G+G P+GSP+RD+IT+AILQLQE +L ++K KWW G CP+E++ A LG+ENIGGIF
Sbjct: 749 GIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIF 808
Query: 825 IVLAAGLVLSVFVAIGEFIYKSRKNNDIEQCLSFNAIMEEL--GISLKNQKKIKKKSRTK 882
IVL GL+++VFVA+ EFI+ +R++ + E+ +++EL +S + + +++ R
Sbjct: 809 IVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRPG 868
Query: 883 GKS 885
G S
Sbjct: 869 GPS 871
>gi|29029595 glutamate receptor KA1 precursor [Homo sapiens]
Length = 956
Score = 669 bits (1727), Expect = 0.0
Identities = 370/852 (43%), Positives = 519/852 (60%), Gaps = 23/852 (2%)
Query: 28 ILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLF 87
++ +P LRI I + E E L+ A INR + + DI +
Sbjct: 16 VMVACSPHSLRIAAILDD-PMECSRGERLSITLAKNRINRAPERLGKAKVEVDIFELLRD 74
Query: 88 DSFEASRRACDQLALGVAALFGPSHS-SSVSAVQSICNALEVPHIQTRWKHPSVDNKDLF 146
+E + C L GV A+ GPS S +S S + +IC EVPH + P K F
Sbjct: 75 SEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKVA---PEEFVKFQF 131
Query: 147 Y----INLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKI 202
+NL+P IS A+ ++ ++N T ++ + L+ L++L++ + +
Sbjct: 132 QRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSV 191
Query: 203 RQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDL 262
R L +D PLLKE++ K +I + + IL + +GM++ YY Y FT L+
Sbjct: 192 RMLDD-TRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEF 250
Query: 263 FALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSME-RLQAPPRPETGLLDGMMTTEA 321
++ VN+ GF + N + + + + P TG +
Sbjct: 251 SLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTG-----PALSS 305
Query: 322 ALMYDAVYMVAIAS---HRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITF 378
AL++DAVY V A +R+ ++ V L C + W+ G MN ++ +GLTGHI F
Sbjct: 306 ALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEF 365
Query: 379 NKTNGLRKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTT 438
N + G R ++ L I+ G +IG W+ GL+M DS+ +SNI+D+L N TL+VTT
Sbjct: 366 N-SKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSM-DSHL-YASNISDTLFNTTLVVTT 422
Query: 439 ILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEW 498
ILE PY+M + + + + GNDR+EG+C+D+LKEL+ IL F Y ++LV DG YG G W
Sbjct: 423 ILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTW 482
Query: 499 NGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNP 558
GMV ELI +ADLAVA LTIT REKVIDFSKPFMTLGISILYR G PG FSFL+P
Sbjct: 483 TGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDP 542
Query: 559 LSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDS-DVVENNFTLLNSFWFGVG 617
SP +W+++LLA L VSCVLF++AR TPYEWY+PHPC +++ N ++L NS WF VG
Sbjct: 543 FSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVG 602
Query: 618 ALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQ 677
MQQGS + P+ALSTR V G+WW FTLIIISSYTANLAAFLTV+RM+ PI+S DDLA Q
Sbjct: 603 GFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQ 662
Query: 678 TKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLM 737
T IEYG + GS+MTFF+ S+ TY++MW +M S+Q + V++++EGI RVL ++YA L+
Sbjct: 663 TAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAFLL 722
Query: 738 ESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEK 797
EST EY QRNCNLTQIGGL+D+KGYG+G P+GS +RD+ +AILQLQE +L ++K K
Sbjct: 723 ESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRK 782
Query: 798 WWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQCLS 857
WW G CP+E++ A LG+ENIGGIF+VL GL++++F+A+ EF++ R + E +
Sbjct: 783 WWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEATEVSVC 842
Query: 858 FNAIMEELGISL 869
+ E I L
Sbjct: 843 QEMVTELRSIIL 854
>gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [Homo
sapiens]
Length = 906
Score = 614 bits (1584), Expect = e-175
Identities = 343/847 (40%), Positives = 515/847 (60%), Gaps = 42/847 (4%)
Query: 24 FLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQR 83
FL ++ P ++IGG+F +++ E AF+FA++ + L+P I
Sbjct: 12 FLGAVVGANFPNNIQIGGLFPNQQSQ----EHAAFRFALSQLTEPPKLLPQ------IDI 61
Query: 84 INLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNK 143
+N+ DSFE + R C Q + GV A+FG +V+ + S C AL V I + VD
Sbjct: 62 VNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFP---VDTS 118
Query: 144 DLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIK-I 202
+ F + L P+ + A++ ++ +Y W+ +Y+ GL LQ+++ + N ++ +
Sbjct: 119 NQFVLQLRPE---LQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAV 175
Query: 203 RQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDL 262
L + + + L ++++K KE V+ DC E IL QI+ + YHY L
Sbjct: 176 NILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYILANLGF 235
Query: 263 FALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAA 322
+DL ++ SG N+TGF+L+N + + I+++W + R T + +A
Sbjct: 236 MDIDLNKFKESGANVTGFQLVNYTDTIPAKIMQQWK----NSDARDHTRVDWKRPKYTSA 291
Query: 323 LMYDAVYMVAIA--SHRASQLTVS------SLQCHRHKPWRLGPRFMNLIKEARWDGLTG 374
L YD V ++A A S R ++ +S + PW G +++ R++GLTG
Sbjct: 292 LTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTG 351
Query: 375 HITFNKTNGLRKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTL 434
++ FN+ G R ++ L +I +K +G KIG WN + + + ++ S+ NRT
Sbjct: 352 NVQFNE-KGRRTNYTLHVIEMKHDGIRKIGYWNEDDKF-VPAATDAQAGGDNSSVQNRTY 409
Query: 435 IVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQN- 493
IVTTILE+PYVM +K+ GNDR+EGYC++L E++ +G+ Y +++V DGKYGA++
Sbjct: 410 IVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDP 469
Query: 494 DKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVF 553
D WNGMV EL+ RAD+AVAPLTIT VRE+VIDFSKPFM+LGISI+ +KP + PGVF
Sbjct: 470 DTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVF 529
Query: 554 SFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPH---PCNPDSDVVENNFTLLN 610
SFL+PL+ +IWM ++ A +GVS VLF+++RF+PYEW++ + + N F + N
Sbjct: 530 SFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFN 589
Query: 611 SFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDS 670
S WF +GA MQQG ++ P++LS RIVGG+WWFFTLIIISSYTANLAAFLTVERM SPI+S
Sbjct: 590 SLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES 649
Query: 671 ADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLT 730
A+DLAKQT+I YG + GST FF++SKI+ +EKMW +M S + + VR ++EG+ RV
Sbjct: 650 AEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRK 709
Query: 731 T--DYALLMESTSIEYVTQRN-CNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQE 787
+ YA L+EST EY+ QR C+ ++GG +DSKGYG+ TP GS R + +A+L+L E
Sbjct: 710 SKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRGPVNLAVLKLSE 769
Query: 788 EGKLHMMKEKWWRGNG-CPEEDN---KEASALGVENIGGIFIVLAAGLVLSVFVAIGEFI 843
+G L +K KWW G C +D+ + SAL + N+ G+F +L GL L++ VA+ EF
Sbjct: 770 QGVLDKLKSKWWYDKGECGSKDSGSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFC 829
Query: 844 YKSRKNN 850
YKSR +
Sbjct: 830 YKSRSES 836
>gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [Homo
sapiens]
Length = 906
Score = 613 bits (1580), Expect = e-175
Identities = 342/847 (40%), Positives = 514/847 (60%), Gaps = 42/847 (4%)
Query: 24 FLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQR 83
FL ++ P ++IGG+F +++ E AF+FA++ + L+P I
Sbjct: 12 FLGAVVGANFPNNIQIGGLFPNQQSQ----EHAAFRFALSQLTEPPKLLPQ------IDI 61
Query: 84 INLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNK 143
+N+ DSFE + R C Q + GV A+FG +V+ + S C AL V I + VD
Sbjct: 62 VNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFP---VDTS 118
Query: 144 DLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIK-I 202
+ F + L P+ + A++ ++ +Y W+ +Y+ GL LQ+++ + N ++ +
Sbjct: 119 NQFVLQLRPE---LQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAV 175
Query: 203 RQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDL 262
L + + + L ++++K KE V+ DC E IL QI+ + YHY L
Sbjct: 176 NILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYILANLGF 235
Query: 263 FALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAA 322
+DL ++ SG N+TGF+L+N + + I+++W + R T + +A
Sbjct: 236 MDIDLNKFKESGANVTGFQLVNYTDTIPAKIMQQWK----NSDARDHTRVDWKRPKYTSA 291
Query: 323 LMYDAVYMVAIA--SHRASQLTVS------SLQCHRHKPWRLGPRFMNLIKEARWDGLTG 374
L YD V ++A A S R ++ +S + PW G +++ R++GLTG
Sbjct: 292 LTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTG 351
Query: 375 HITFNKTNGLRKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTL 434
++ FN+ G R ++ L +I +K +G KIG WN + + + ++ S+ NRT
Sbjct: 352 NVQFNE-KGRRTNYTLHVIEMKHDGIRKIGYWNEDDKF-VPAATDAQAGGDNSSVQNRTY 409
Query: 435 IVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQN- 493
IVTTILE+PYVM +K+ GNDR+EGYC++L E++ +G+ Y +++V DGKYGA++
Sbjct: 410 IVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDP 469
Query: 494 DKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVF 553
D WNGMV EL+ RAD+AVAPLTIT VRE+VIDFSKPFM+LGISI+ +KP + PGVF
Sbjct: 470 DTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVF 529
Query: 554 SFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPH---PCNPDSDVVENNFTLLN 610
SFL+PL+ +IWM ++ A +GVS VLF+++RF+PYEW++ + + N F + N
Sbjct: 530 SFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFN 589
Query: 611 SFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDS 670
S WF +GA MQQG ++ P++LS RIVGG+WWFFTLIIISSYTANLAAFLTVERM SPI+S
Sbjct: 590 SLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES 649
Query: 671 ADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLT 730
A+DLAKQT+I YG + GST FF++SKI+ +EKMW +M S + + VR ++EG+ RV
Sbjct: 650 AEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRK 709
Query: 731 T--DYALLMESTSIEYVTQRN-CNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQE 787
+ YA L+EST EY+ QR C+ ++GG +DSKGYG+ TP GS R+ + +A+L+L E
Sbjct: 710 SKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNE 769
Query: 788 EGKLHMMKEKWWRGNG-CPE---EDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFI 843
+G L +K KWW G C + + SAL + N+ G+F +L GL L++ VA+ EF
Sbjct: 770 QGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFC 829
Query: 844 YKSRKNN 850
YKSR +
Sbjct: 830 YKSRSES 836
>gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1
precursor [Homo sapiens]
Length = 894
Score = 600 bits (1546), Expect = e-171
Identities = 347/846 (41%), Positives = 507/846 (59%), Gaps = 57/846 (6%)
Query: 34 PQVLRIGGIF--ETVENEPVNVEELAFKFAVTSINRNRTLMPNTT-----LTYDIQRINL 86
P + IGG+F TV+ E AF+FAV N N+ NTT L Y + ++
Sbjct: 31 PNTISIGGLFMRNTVQ------EHSAFRFAVQLYNTNQ----NTTEKPFHLNYHVDHLDS 80
Query: 87 FDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDLF 146
+SF + C Q + GV A+FG S++ + S C AL + + D F
Sbjct: 81 SNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFP---TDADVQF 137
Query: 147 YINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLP 206
I + P A+ AIL L+ +Y W+ +Y+ G LQ +++A + N ++ R +
Sbjct: 138 VIQMRP---ALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSV- 193
Query: 207 SGN----KDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDL 262
GN ++ + +++EM + +E + DC E IL+Q++ +G + YHY L
Sbjct: 194 -GNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGF 252
Query: 263 FALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAA 322
+ LE + G N+TGF+++N +NP V I++W RL PE + + +A
Sbjct: 253 TDILLERVMHGGANITGFQIVNNENPMVQQFIQRWV--RLDEREFPEAK--NAPLKYTSA 308
Query: 323 LMYDAVYMVAIASH--RASQLTVS------SLQCHRHKPWRLGPRFMNLIKEARWDGLTG 374
L +DA+ ++A A R ++ VS + PW G +K + G+TG
Sbjct: 309 LTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTG 368
Query: 375 HITFNKTNGLRKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTL 434
+I F+ T G R ++ +D+ +K G+ K G WN + + SN + S NRT+
Sbjct: 369 NIQFD-TYGRRTNYTIDVYEMKVSGSRKAGYWNEYE--RFVPFSDQQISNDSASSENRTI 425
Query: 435 IVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQND 494
+VTTILE PYVMY+K+ + L GN+R+EGYC+DL E++ + Y + +V DGKYGA++
Sbjct: 426 VVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDP 485
Query: 495 KGE-WNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVF 553
+ + WNGMV EL+ RAD+AVAPLTIT VRE+VIDFSKPFM+LGISI+ +KP + PGVF
Sbjct: 486 ETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVF 545
Query: 554 SFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWY----NPHPCNPDSDV-VENNFTL 608
SFL+PL+ +IWM ++ A +GVS VLF+++RF+PYEW+ N P +P S N F +
Sbjct: 546 SFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGI 605
Query: 609 LNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPI 668
NS WF +GA MQQG ++ P++LS RIVGG+WWFFTLIIISSYTANLAAFLTVERM SPI
Sbjct: 606 FNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPI 665
Query: 669 DSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRV 728
+SA+DLAKQT+I YG + GST FF++SKI+ YEKMW++M S + + + + +G+ RV
Sbjct: 666 ESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARV 725
Query: 729 LTT--DYALLMESTSIEYVTQRN-CNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQL 785
+ +A L+EST EY+ QR C+ ++GG +DSKGYGV TP GS + +A+L+L
Sbjct: 726 RKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLKL 785
Query: 786 QEEGKLHMMKEKWWRGNG-CPEEDN---KEASALGVENIGGIFIVLAAGLVLSVFVAIGE 841
E+G L +K KWW G C +D+ + SAL + N+ G+F +L GL L++ VA+ E
Sbjct: 786 SEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIE 845
Query: 842 FIYKSR 847
F YKSR
Sbjct: 846 FCYKSR 851
>gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2
precursor [Homo sapiens]
Length = 894
Score = 599 bits (1544), Expect = e-171
Identities = 346/846 (40%), Positives = 506/846 (59%), Gaps = 57/846 (6%)
Query: 34 PQVLRIGGIF--ETVENEPVNVEELAFKFAVTSINRNRTLMPNTT-----LTYDIQRINL 86
P + IGG+F TV+ E AF+FAV N N+ NTT L Y + ++
Sbjct: 31 PNTISIGGLFMRNTVQ------EHSAFRFAVQLYNTNQ----NTTEKPFHLNYHVDHLDS 80
Query: 87 FDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDLF 146
+SF + C Q + GV A+FG S++ + S C AL + + D F
Sbjct: 81 SNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFP---TDADVQF 137
Query: 147 YINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLP 206
I + P A+ AIL L+ +Y W+ +Y+ G LQ +++A + N ++ R +
Sbjct: 138 VIQMRP---ALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSV- 193
Query: 207 SGN----KDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDL 262
GN ++ + +++EM + +E + DC E IL+Q++ +G + YHY L
Sbjct: 194 -GNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGF 252
Query: 263 FALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAA 322
+ LE + G N+TGF+++N +NP V I++W RL PE + + +A
Sbjct: 253 TDILLERVMHGGANITGFQIVNNENPMVQQFIQRWV--RLDEREFPEAK--NAPLKYTSA 308
Query: 323 LMYDAVYMVAIASH--RASQLTVS------SLQCHRHKPWRLGPRFMNLIKEARWDGLTG 374
L +DA+ ++A A R ++ VS + PW G +K + G+TG
Sbjct: 309 LTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTG 368
Query: 375 HITFNKTNGLRKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTL 434
+I F+ T G R ++ +D+ +K G+ K G WN + + SN + S NRT+
Sbjct: 369 NIQFD-TYGRRTNYTIDVYEMKVSGSRKAGYWNEYE--RFVPFSDQQISNDSASSENRTI 425
Query: 435 IVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQND 494
+VTTILE PYVMY+K+ + L GN+R+EGYC+DL E++ + Y + +V DGKYGA++
Sbjct: 426 VVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDP 485
Query: 495 KGE-WNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVF 553
+ + WNGMV EL+ RAD+AVAPLTIT VRE+VIDFSKPFM+LGISI+ +KP + PGVF
Sbjct: 486 ETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVF 545
Query: 554 SFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWY----NPHPCNPDSDV-VENNFTL 608
SFL+PL+ +IWM ++ A +GVS VLF+++RF+PYEW+ N P +P S N F +
Sbjct: 546 SFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGI 605
Query: 609 LNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPI 668
NS WF +GA MQQG ++ P++LS RIVGG+WWFFTLIIISSYTANLAAFLTVERM SPI
Sbjct: 606 FNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPI 665
Query: 669 DSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRV 728
+SA+DLAKQT+I YG + GST FF++SKI+ YEKMW++M S + + + + +G+ RV
Sbjct: 666 ESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARV 725
Query: 729 LTT--DYALLMESTSIEYVTQRN-CNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQL 785
+ +A L+EST EY+ QR C+ ++GG +DSKGYGV TP GS + + +A+L+L
Sbjct: 726 RKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGNAVNLAVLKL 785
Query: 786 QEEGKLHMMKEKWWRGNG-CPE---EDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGE 841
E+G L +K KWW G C + + SAL + N+ G+F +L GL L++ VA+ E
Sbjct: 786 NEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIE 845
Query: 842 FIYKSR 847
F YKSR
Sbjct: 846 FCYKSR 851
>gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1
precursor [Homo sapiens]
Length = 883
Score = 593 bits (1529), Expect = e-169
Identities = 337/839 (40%), Positives = 499/839 (59%), Gaps = 53/839 (6%)
Query: 37 LRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRA 96
++IGG+F ++ E AF+ + + + LT I + + +SF +
Sbjct: 27 IQIGGLFPRGADQ----EYSAFRVGMVQFSTSEF-----RLTPHIDNLEVANSFAVTNAF 77
Query: 97 CDQLALGVAALFGPSHSSSVSAVQSICNALEV----PHIQTRWKHPSVDNKDLFYINLYP 152
C Q + GV A+FG SV+ + S C L V P T HP F I + P
Sbjct: 78 CSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHP-------FVIQMRP 130
Query: 153 DYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDA 212
D + A+L L+ YY W +Y+ GL LQ ++ + + ++ + + N D
Sbjct: 131 D---LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDK 187
Query: 213 KP-----LLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDL 267
K L ++++ KE VI DC + +I+ Q++ +G + YHY L DL
Sbjct: 188 KDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDL 247
Query: 268 ELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDA 327
++ G N++GF++++ D+ VS IE+WS + P T + +AL YDA
Sbjct: 248 LKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIK----YTSALTYDA 303
Query: 328 VYMV--AIASHRASQLTVS------SLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFN 379
V ++ A + R ++ +S + PW G +K+ + +GL+G+I F+
Sbjct: 304 VQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFD 363
Query: 380 KTNGLRKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTI 439
+ NG R ++ ++I+ LK G KIG W+ + +T + S N T L N+T++VTTI
Sbjct: 364 Q-NGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELP-SGNDTSGLENKTVVVTTI 421
Query: 440 LEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQN-DKGEW 498
LE PYVM +K+ + L GN+R+EGYC+DL E++ GF Y + +V DGKYGA++ D W
Sbjct: 422 LESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIW 481
Query: 499 NGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNP 558
NGMV EL+ +AD+A+APLTIT VRE+VIDFSKPFM+LGISI+ +KP + PGVFSFL+P
Sbjct: 482 NGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDP 541
Query: 559 LSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPH---PCNPDSDVVENNFTLLNSFWFG 615
L+ +IWM ++ A +GVS VLF+++RF+PYEW+ S N F + NS WF
Sbjct: 542 LAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFS 601
Query: 616 VGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLA 675
+GA M+QG ++ P++LS RIVGG+WWFFTLIIISSYTANLAAFLTVERM SPI+SA+DL+
Sbjct: 602 LGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLS 661
Query: 676 KQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTT--DY 733
KQT+I YG + GST FF++SKI+ ++KMW +M S + + VR + EG+ RV + Y
Sbjct: 662 KQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKY 721
Query: 734 ALLMESTSIEYVTQRN-CNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLH 792
A L+EST EY+ QR C+ ++GG +DSKGYG+ TP GS R + +A+L+L E+G L
Sbjct: 722 AYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLD 781
Query: 793 MMKEKWWRGNG-CPEEDN---KEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSR 847
+K KWW G C +D+ ++ SAL + N+ G+F +L GL L++ VA+ EF YKSR
Sbjct: 782 KLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR 840
>gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2
precursor [Homo sapiens]
Length = 883
Score = 592 bits (1526), Expect = e-169
Identities = 336/839 (40%), Positives = 498/839 (59%), Gaps = 53/839 (6%)
Query: 37 LRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRA 96
++IGG+F ++ E AF+ + + + LT I + + +SF +
Sbjct: 27 IQIGGLFPRGADQ----EYSAFRVGMVQFSTSEF-----RLTPHIDNLEVANSFAVTNAF 77
Query: 97 CDQLALGVAALFGPSHSSSVSAVQSICNALEV----PHIQTRWKHPSVDNKDLFYINLYP 152
C Q + GV A+FG SV+ + S C L V P T HP F I + P
Sbjct: 78 CSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHP-------FVIQMRP 130
Query: 153 DYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDA 212
D + A+L L+ YY W +Y+ GL LQ ++ + + ++ + + N D
Sbjct: 131 D---LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDK 187
Query: 213 KP-----LLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDL 267
K L ++++ KE VI DC + +I+ Q++ +G + YHY L DL
Sbjct: 188 KDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDL 247
Query: 268 ELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDA 327
++ G N++GF++++ D+ VS IE+WS + P T + +AL YDA
Sbjct: 248 LKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIK----YTSALTYDA 303
Query: 328 VYMV--AIASHRASQLTVS------SLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFN 379
V ++ A + R ++ +S + PW G +K+ + +GL+G+I F+
Sbjct: 304 VQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFD 363
Query: 380 KTNGLRKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTI 439
+ NG R ++ ++I+ LK G KIG W+ + +T + S N T L N+T++VTTI
Sbjct: 364 Q-NGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELP-SGNDTSGLENKTVVVTTI 421
Query: 440 LEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQN-DKGEW 498
LE PYVM +K+ + L GN+R+EGYC+DL E++ GF Y + +V DGKYGA++ D W
Sbjct: 422 LESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIW 481
Query: 499 NGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNP 558
NGMV EL+ +AD+A+APLTIT VRE+VIDFSKPFM+LGISI+ +KP + PGVFSFL+P
Sbjct: 482 NGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDP 541
Query: 559 LSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPH---PCNPDSDVVENNFTLLNSFWFG 615
L+ +IWM ++ A +GVS VLF+++RF+PYEW+ S N F + NS WF
Sbjct: 542 LAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFS 601
Query: 616 VGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLA 675
+GA M+QG ++ P++LS RIVGG+WWFFTLIIISSYTANLAAFLTVERM SPI+SA+DL+
Sbjct: 602 LGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLS 661
Query: 676 KQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTT--DY 733
KQT+I YG + GST FF++SKI+ ++KMW +M S + + VR + EG+ RV + Y
Sbjct: 662 KQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKY 721
Query: 734 ALLMESTSIEYVTQRN-CNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLH 792
A L+EST EY+ QR C+ ++GG +DSKGYG+ TP GS R+ + +A+L+L E+G L
Sbjct: 722 AYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLD 781
Query: 793 MMKEKWWRGNG-CPE---EDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSR 847
+K KWW G C + ++ SAL + N+ G+F +L GL L++ VA+ EF YKSR
Sbjct: 782 KLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR 840
>gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [Homo
sapiens]
Length = 836
Score = 592 bits (1525), Expect = e-169
Identities = 330/799 (41%), Positives = 483/799 (60%), Gaps = 44/799 (5%)
Query: 77 LTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEV----PHIQ 132
LT I + + +SF + C Q + GV A+FG SV+ + S C L V P
Sbjct: 11 LTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFP 70
Query: 133 TRWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKA 192
T HP F I + PD + A+L L+ YY W +Y+ GL LQ ++ +
Sbjct: 71 TDGTHP-------FVIQMRPD---LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDS 120
Query: 193 PSRYNIKIKIRQLPSGNKDAKP-----LLKEMKKGKEFYVIFDCSHETAAEILKQILFMG 247
+ ++ + + N D K L ++++ KE VI DC + +I+ Q++ +G
Sbjct: 121 AAEKKWQVTAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIG 180
Query: 248 MMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPR 307
+ YHY L DL ++ G N++GF++++ D+ VS IE+WS + P
Sbjct: 181 KHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPG 240
Query: 308 PETGLLDGMMTTEAALMYDAVYMV--AIASHRASQLTVS------SLQCHRHKPWRLGPR 359
T + +AL YDAV ++ A + R ++ +S + PW G
Sbjct: 241 AHTTTIK----YTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVE 296
Query: 360 FMNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNK 419
+K+ + +GL+G+I F++ NG R ++ ++I+ LK G KIG W+ + +T +
Sbjct: 297 IERALKQVQVEGLSGNIKFDQ-NGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTEL 355
Query: 420 DKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIY 479
S N T L N+T++VTTILE PYVM +K+ + L GN+R+EGYC+DL E++ GF Y
Sbjct: 356 P-SGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKY 414
Query: 480 DVKLVPDGKYGAQN-DKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGI 538
+ +V DGKYGA++ D WNGMV EL+ +AD+A+APLTIT VRE+VIDFSKPFM+LGI
Sbjct: 415 KLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGI 474
Query: 539 SILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPH---PC 595
SI+ +KP + PGVFSFL+PL+ +IWM ++ A +GVS VLF+++RF+PYEW+
Sbjct: 475 SIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGR 534
Query: 596 NPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANL 655
S N F + NS WF +GA M+QG ++ P++LS RIVGG+WWFFTLIIISSYTANL
Sbjct: 535 ETQSSESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANL 594
Query: 656 AAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQT 715
AAFLTVERM SPI+SA+DL+KQT+I YG + GST FF++SKI+ ++KMW +M S + +
Sbjct: 595 AAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPS 654
Query: 716 ALVRNSDEGIQRVLTT--DYALLMESTSIEYVTQRN-CNLTQIGGLIDSKGYGVGTPIGS 772
VR + EG+ RV + YA L+EST EY+ QR C+ ++GG +DSKGYG+ TP GS
Sbjct: 655 VFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGS 714
Query: 773 PYRDKITIAILQLQEEGKLHMMKEKWWRGNG-CPEEDN---KEASALGVENIGGIFIVLA 828
R + +A+L+L E+G L +K KWW G C +D+ ++ SAL + N+ G+F +L
Sbjct: 715 SLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILV 774
Query: 829 AGLVLSVFVAIGEFIYKSR 847
GL L++ VA+ EF YKSR
Sbjct: 775 GGLGLAMLVALIEFCYKSR 793
>gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2
precursor [Homo sapiens]
Length = 884
Score = 588 bits (1517), Expect = e-168
Identities = 332/834 (39%), Positives = 490/834 (58%), Gaps = 36/834 (4%)
Query: 34 PQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEAS 93
P ++IGG+F ++ LA TS N + L + I +SF +
Sbjct: 24 PSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPF---NLVPHVDNIETANSFAVT 80
Query: 94 RRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDLFYINLYPD 153
C Q + GV A+FG SV + S C+AL + I + + + F + L P
Sbjct: 81 NAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFP---TEGESQFVLQLRP- 136
Query: 154 YAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDA- 212
++ A+L L+ +Y W +Y+ G LQ +++ + + + + N +
Sbjct: 137 --SLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSY 194
Query: 213 KPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRY 272
+ LL+E+ + +E + DC E IL+QI+ +G + YHY L + LE + +
Sbjct: 195 RQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIH 254
Query: 273 SGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDAVYMVA 332
G N+TGF+L++ + P V ++++W + P ET +AL YD V ++A
Sbjct: 255 GGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSETP-----PKYTSALTYDGVLVMA 309
Query: 333 --IASHRASQLTVS------SLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNGL 384
S R ++ +S + PW G +K+ R GLTG++ F+ G
Sbjct: 310 ETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHY-GR 368
Query: 385 RKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPY 444
R ++ +D+ LK G K+G WN L + + N T ++ NRT++VTTI+E PY
Sbjct: 369 RVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQ-DVPTLGNDTAAIENRTVVVTTIMESPY 427
Query: 445 VMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQN-DKGEWNGMVK 503
VMY+K+ + GND++EGYC+DL E++ +G Y + +VPDGKYGA++ D WNGMV
Sbjct: 428 VMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVG 487
Query: 504 ELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDI 563
EL+ +A++A+APLTIT VRE+VIDFSKPFM+LGISI+ +KP + PGVFSFL+PL+ +I
Sbjct: 488 ELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEI 547
Query: 564 WMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPD---SDVVENNFTLLNSFWFGVGALM 620
WM ++ A +GVS VLF+++RF+PYEW+ P + SD N F + NS WF +GA M
Sbjct: 548 WMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFM 607
Query: 621 QQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKI 680
QQG ++ P++LS RIVGG+WWFFTLIIISSYTANLAAFLTVERM SPI+SA+DLAKQT+I
Sbjct: 608 QQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEI 667
Query: 681 EYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTT--DYALLME 738
YG + GST FF++SKI+ YEKMW +M S + + R + EG+ RV + +A L+E
Sbjct: 668 AYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLE 727
Query: 739 STSIEYVTQRN-CNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEK 797
ST EY+ QR C+ ++GG +DSKGYGV TP GS + + +A+L+L E+G L +K K
Sbjct: 728 STMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLGNAVNLAVLKLNEQGLLDKLKNK 787
Query: 798 WWRGNG-CPE---EDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSR 847
WW G C + + SAL + N+ G+F +L GL L++ VA+ EF YKSR
Sbjct: 788 WWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR 841
>gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1
precursor [Homo sapiens]
Length = 902
Score = 588 bits (1517), Expect = e-168
Identities = 333/834 (39%), Positives = 490/834 (58%), Gaps = 36/834 (4%)
Query: 34 PQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEAS 93
P ++IGG+F ++ LA TS N + L + I +SF +
Sbjct: 24 PSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPF---NLVPHVDNIETANSFAVT 80
Query: 94 RRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDLFYINLYPD 153
C Q + GV A+FG SV + S C+AL + I + + + F + L P
Sbjct: 81 NAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFP---TEGESQFVLQLRP- 136
Query: 154 YAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDA- 212
++ A+L L+ +Y W +Y+ G LQ +++ + + + + N +
Sbjct: 137 --SLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSY 194
Query: 213 KPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRY 272
+ LL+E+ + +E + DC E IL+QI+ +G + YHY L + LE + +
Sbjct: 195 RQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIH 254
Query: 273 SGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDAVYMVA 332
G N+TGF+L++ + P V ++++W + P ET +AL YD V ++A
Sbjct: 255 GGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSETP-----PKYTSALTYDGVLVMA 309
Query: 333 --IASHRASQLTVS------SLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNGL 384
S R ++ +S + PW G +K+ R GLTG++ F+ G
Sbjct: 310 ETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHY-GR 368
Query: 385 RKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPY 444
R ++ +D+ LK G K+G WN L + + N T ++ NRT++VTTI+E PY
Sbjct: 369 RVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQ-DVPTLGNDTAAIENRTVVVTTIMESPY 427
Query: 445 VMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQN-DKGEWNGMVK 503
VMY+K+ + GND++EGYC+DL E++ +G Y + +VPDGKYGA++ D WNGMV
Sbjct: 428 VMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVG 487
Query: 504 ELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDI 563
EL+ +A++A+APLTIT VRE+VIDFSKPFM+LGISI+ +KP + PGVFSFL+PL+ +I
Sbjct: 488 ELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEI 547
Query: 564 WMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPD---SDVVENNFTLLNSFWFGVGALM 620
WM ++ A +GVS VLF+++RF+PYEW+ P + SD N F + NS WF +GA M
Sbjct: 548 WMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFM 607
Query: 621 QQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKI 680
QQG ++ P++LS RIVGG+WWFFTLIIISSYTANLAAFLTVERM SPI+SA+DLAKQT+I
Sbjct: 608 QQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEI 667
Query: 681 EYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTT--DYALLME 738
YG + GST FF++SKI+ YEKMW +M S + + R + EG+ RV + +A L+E
Sbjct: 668 AYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLE 727
Query: 739 STSIEYVTQRN-CNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEK 797
ST EY+ QR C+ ++GG +DSKGYGV TP GS + +A+L+L E G L +K K
Sbjct: 728 STMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLGTPVNLAVLKLSEAGVLDKLKNK 787
Query: 798 WWRGNG-CPEEDN---KEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSR 847
WW G C +D+ + SAL + N+ G+F +L GL L++ VA+ EF YKSR
Sbjct: 788 WWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR 841
>gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [Homo
sapiens]
Length = 1009
Score = 373 bits (958), Expect = e-103
Identities = 271/891 (30%), Positives = 434/891 (48%), Gaps = 95/891 (10%)
Query: 17 TSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTT 76
T W LL ++C + A ++ IG IFE E ++ F+ AV+ ++ N ++ +
Sbjct: 5 TLW-LLPWICQCVSVRADSIIHIGAIFE----ENAAKDDRVFQLAVSDLSLNDDILQSEK 59
Query: 77 LTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWK 136
+TY I+ I + F+A + ACD + G+ AL + +S +A+QS+ +A+ +PH+ + +
Sbjct: 60 ITYSIKVIEANNPFQAVQEACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQ-R 118
Query: 137 HPSVDNKDLFYINLYPD---YAAISR-------AILDLVLYYNWKTVTVVYEDSTGLIRL 186
+P + ++N PD Y SR +L LV W+ + Y+ + L
Sbjct: 119 NPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGL 178
Query: 187 QELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFY--------VIFDCSHETAAE 238
Q + SR + + ++++ L K +E I S + A
Sbjct: 179 QSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHS 238
Query: 239 ILKQILFMGMMTEYYHYFFTTLDLFALD-LELYRYSGVNMTGFRLL----------NIDN 287
+ + + + ++ H+ F ++ + L+L + MT R + +N
Sbjct: 239 FINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNN 298
Query: 288 PHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQ----LTV 343
+SS++ P+ G L M+ +YD+V M+A A HR + ++
Sbjct: 299 HRISSLLCD-----------PQEGYLQ-MLQISNLYLYDSVLMLANAFHRKLEDRKWHSM 346
Query: 344 SSLQCHRH--KPWRLGPRFMNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGT- 400
+SL C R KPW G ++ IK+ GLTG + F R+D + + GT
Sbjct: 347 ASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEF------REDSSNPYVQFEILGTT 400
Query: 401 ---------EKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSD 451
K+ W+S GLN + + S L TL V T+LEEP+VM ++
Sbjct: 401 YSETFGKDMRKLATWDSEKGLNGSLQERPMGSR----LQGLTLKVVTVLEEPFVMV--AE 454
Query: 452 KPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRAD 511
L R++G+ +D+L L+ LGF Y++ PDG+YG Q WNGM+ ELI RAD
Sbjct: 455 NILGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRAD 514
Query: 512 LAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLAC 571
LA++ +TIT RE V+DFSK +M + IL +KP +FS P +W + A
Sbjct: 515 LAISAITITPERESVVDFSKRYMDYSVGILIKKPE-EKISIFSLFAPFDFAVWACIAAAI 573
Query: 572 LGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKAL 631
V ++FV+ R + P + TL ++ W GA +QQG E ++
Sbjct: 574 PVVGVLIFVLNRIQAVRAQSAAQPRPSASA-----TLHSAIWIVYGAFVQQGGESSVNSM 628
Query: 632 STRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTM 691
+ RIV G WW FTLI+ SSYTANLAAFLTV RM++PI + DL+KQ ++ YG VRD +
Sbjct: 629 AMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVY 688
Query: 692 TFFKK------SKISTYEKMWAFMSSR-QQTALVRNSDEGIQRVLTTDYALLMESTSIEY 744
+F+ + ST+ ++W +S V + EGI++ +YA L + +EY
Sbjct: 689 EYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGNYAFLWDVAVVEY 748
Query: 745 --VTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGN 802
+T +C++T IG I SKGYG+ GSPYRD + IL+LQ+ G L ++K+KWW
Sbjct: 749 AALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHM 808
Query: 803 G-CPEEDNKEASA----LGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRK 848
G C + A A L + + G+F +LA GL+L+ VA E + S +
Sbjct: 809 GRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNSNR 859
>gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens]
Length = 1007
Score = 366 bits (940), Expect = e-101
Identities = 257/863 (29%), Positives = 432/863 (50%), Gaps = 65/863 (7%)
Query: 33 APQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEA 92
A ++ IG IF+ E ++ F+ AV +N+N ++ +T+ + ++ + F+A
Sbjct: 23 ADSIIHIGAIFD----ESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQA 78
Query: 93 SRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPH--IQTRWKHPSVDNKDLFYINL 150
+ AC+ + G+ AL +S ++QS+ +A+ +PH IQ L N
Sbjct: 79 VQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNR 138
Query: 151 YPDYAAISR-------AILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIR 203
DY R IL +V Y W+ + Y+ + +QE + S+ + + ++
Sbjct: 139 NDDYTLSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQ 198
Query: 204 QLPSG-NKDAKPL-----LKEMKKGKEFY--VIFDCSHETAAEILKQILFMGMMTEYYHY 255
++ + NK L ++E+ + ++ I + TA + +++ ++ H+
Sbjct: 199 KVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCHW 258
Query: 256 FFTTLDLFALDL-ELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLD 314
++ +D+ EL R S +T R ++S + + P+
Sbjct: 259 IIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQ 318
Query: 315 GMMTTEAALMYDAVYMVAIASHRASQ----LTVSSLQCHRH--KPWRLGPRFMNLIKEAR 368
M + + YD V ++A A H+ + +++SL C R KPW+ G + IK+
Sbjct: 319 NMEISNLYI-YDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGG 377
Query: 369 WDGLTGHITFNKTNGLRKDFDLDIISLK--EE---GTEKIGIWNSNSGLNMTDSNKDKSS 423
GLTG + F + NG + +I+ EE G K+G WN +GLN + ++K +
Sbjct: 378 VSGLTGELEFGE-NGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLEN 436
Query: 424 NITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKL 483
N+ + L V T+LEEP+VM S+ L +++G+ +D+L LSN LGF Y++ +
Sbjct: 437 NMRGVV----LRVVTVLEEPFVMV--SENVLGKPKKYQGFSIDVLDALSNYLGFNYEIYV 490
Query: 484 VPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYR 543
PD KYG+ + G WNG+V EL+ RAD+ ++ LTIT RE V+DF+ +M + +L R
Sbjct: 491 APDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLR 550
Query: 544 KPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVE 603
+ T +F+ L P +W + L V +++++ W NP S
Sbjct: 551 RAEKT-VDMFACLAPFDLSLWACIAGTVLLVGLLVYLL------NWLNPPRLQMGS---M 600
Query: 604 NNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVER 663
+ TL NS WF G+ +QQG E+ L+TR++ G WW F LI+ISSYTANLAAFLT+ R
Sbjct: 601 TSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITR 660
Query: 664 MESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKI------STYEKMWAFMS-SRQQTA 716
+ES I S DL+KQT+I YG V D + + + S Y +MW ++ S
Sbjct: 661 IESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSEN 720
Query: 717 LVRNSDEGIQRVLTTDYALLMESTSIEYV--TQRNCNLTQIGGLIDSKGYGVGTPIGSPY 774
V S GIQ+V +YA + ++ +EYV +C+ IG + +GYG+ GSPY
Sbjct: 721 NVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPY 780
Query: 775 RDKITIAILQLQEEGKLHMMKEKWWRGNG-----CPEEDNKEASALGVENIGGIFIVLAA 829
RD + IL+LQ+ G + ++K KWW NG + ++ AL +++ G+F +LAA
Sbjct: 781 RDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAA 840
Query: 830 GLVLSVFVAIGEFIYKSRKNNDI 852
G+VLS F+A+ E + RK + +
Sbjct: 841 GIVLSCFIAMLETWWNKRKGSRV 863
>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
Length = 938
Score = 265 bits (677), Expect = 1e-70
Identities = 242/953 (25%), Positives = 436/953 (45%), Gaps = 131/953 (13%)
Query: 20 ALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRN----RTLMPNT 75
ALL+ P+++ IG + T ++E + F+ AV N+ + + T
Sbjct: 10 ALLFSCSVARAACDPKIVNIGAVLSTRKHEQM------FREAVNQANKRHGSWKIQLNAT 63
Query: 76 TLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVP--HIQT 133
++T+ I + S + A+ V+ P+ + + V +P + T
Sbjct: 64 SVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTT 123
Query: 134 RWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDS----TGLIRLQEL 189
R S + L ++ P Y+ S +++ Y+W + ++ D RL+ L
Sbjct: 124 RMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETL 183
Query: 190 IKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMM 249
++ R + K+ Q G K+ LL E K+ + +I S + AA + + + M
Sbjct: 184 LE--ERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMT 241
Query: 250 TEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPE 309
Y + ++ L RY+ + G +L+N N
Sbjct: 242 GSGYVWLVGEREISGNAL---RYAPDGILGLQLINGKN---------------------- 276
Query: 310 TGLLDGMMTTEAALMYDAVYMVAIASHRASQ---LTVSSLQCHRHKP-WRLGPRFMNLIK 365
E+A + DAV +VA A H + +T C + W+ GP F ++
Sbjct: 277 ----------ESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLM 326
Query: 366 EARW-DGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNKD---- 420
+++ DG+TG + FN+ +G RK + I++L+ ++GI+N G ++ +++
Sbjct: 327 SSKYADGVTGRVEFNE-DGDRKFANYSIMNLQNRKLVQVGIYN---GTHVIPNDRKIIWP 382
Query: 421 --KSSNITDSLANRTLIVTTILEEPYVMYR--------KSDKPLYG-----------NDR 459
++ + L + TI +EP+V + K + + G ND
Sbjct: 383 GGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDT 442
Query: 460 FEG------------YCLDLLKELSNILGFIYDVKLVPDGKYGAQ-----NDKGEWNGMV 502
G +C+DLL +L+ + F Y+V LV DGK+G Q ++K EWNGM+
Sbjct: 443 SPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMM 502
Query: 503 KELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRK--PNGTNPGVFSFLNPLS 560
EL+ +AD+ VAPLTI R + I+FSKPF G++IL +K P T + SF+ P
Sbjct: 503 GELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRST---LDSFMQPFQ 559
Query: 561 PDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALM 620
+W+ V L+ V+ +L+++ RF+P+ + + + D + TL ++ WF G L+
Sbjct: 560 STLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDAL----TLSSAMWFSWGVLL 615
Query: 621 QQG-SELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQT- 678
G E P++ S RI+G +W F +II++SYTANLAAFL ++R E I +D +
Sbjct: 616 NSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNP 675
Query: 679 --KIEYGAVRDGSTMTFFKKS-KISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTD-YA 734
K Y V+ S +F++ ++ST M+ M ++ E IQ V +A
Sbjct: 676 SDKFIYATVKQSSVDIYFRRQVELST---MYRHMEKHN----YESAAEAIQAVRDNKLHA 728
Query: 735 LLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMM 794
+ +S +E+ + C+L G L G+G+G SP++ ++++IL+ E G + +
Sbjct: 729 FIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDL 788
Query: 795 KEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQ 854
+ W R C N A+ L EN+ G+F+++A G+V +F+ E YK K+ +Q
Sbjct: 789 DKTWVRYQECDSRSNAPAT-LTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQ 847
Query: 855 CLSFNAIMEELGISLKNQKKIKKKSRTKGKSSF----TSILTCHQRRTQRKET 903
A + +L+++K + + K K++F +++ + +RR K+T
Sbjct: 848 MQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDT 900
>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
Length = 885
Score = 260 bits (664), Expect = 5e-69
Identities = 235/908 (25%), Positives = 416/908 (45%), Gaps = 128/908 (14%)
Query: 20 ALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRN----RTLMPNT 75
ALL+ P+++ IG + T ++E + F+ AV N+ + + T
Sbjct: 10 ALLFSCSVARAACDPKIVNIGAVLSTRKHEQM------FREAVNQANKRHGSWKIQLNAT 63
Query: 76 TLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVP--HIQT 133
++T+ I + S + A+ V+ P+ + + V +P + T
Sbjct: 64 SVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTT 123
Query: 134 RWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDS----TGLIRLQEL 189
R S + L ++ P Y+ S +++ Y+W + ++ D RL+ L
Sbjct: 124 RMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETL 183
Query: 190 IKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMM 249
++ R + K+ Q G K+ LL E K+ + +I S + AA + + + M
Sbjct: 184 LE--ERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMT 241
Query: 250 TEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPE 309
Y + ++ L RY+ + G +L+N N
Sbjct: 242 GSGYVWLVGEREISGNAL---RYAPDGILGLQLINGKN---------------------- 276
Query: 310 TGLLDGMMTTEAALMYDAVYMVAIASHRASQ---LTVSSLQCHRHKP-WRLGPRFMNLIK 365
E+A + DAV +VA A H + +T C + W+ GP F ++
Sbjct: 277 ----------ESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLM 326
Query: 366 EARW-DGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNKD---- 420
+++ DG+TG + FN+ +G RK + I++L+ ++GI+N G ++ +++
Sbjct: 327 SSKYADGVTGRVEFNE-DGDRKFANYSIMNLQNRKLVQVGIYN---GTHVIPNDRKIIWP 382
Query: 421 --KSSNITDSLANRTLIVTTILEEPYVMYR--------KSDKPLYG-----------NDR 459
++ + L + TI +EP+V + K + + G ND
Sbjct: 383 GGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDT 442
Query: 460 FEG------------YCLDLLKELSNILGFIYDVKLVPDGKYGAQ-----NDKGEWNGMV 502
G +C+DLL +L+ + F Y+V LV DGK+G Q ++K EWNGM+
Sbjct: 443 SPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMM 502
Query: 503 KELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRK--PNGTNPGVFSFLNPLS 560
EL+ +AD+ VAPLTI R + I+FSKPF G++IL +K P T + SF+ P
Sbjct: 503 GELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRST---LDSFMQPFQ 559
Query: 561 PDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALM 620
+W+ V L+ V+ +L+++ RF+P+ + + + D + TL ++ WF G L+
Sbjct: 560 STLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDAL----TLSSAMWFSWGVLL 615
Query: 621 QQG-SELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQT- 678
G E P++ S RI+G +W F +II++SYTANLAAFL ++R E I +D +
Sbjct: 616 NSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNP 675
Query: 679 --KIEYGAVRDGSTMTFFKKS-KISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTD-YA 734
K Y V+ S +F++ ++ST M+ M ++ E IQ V +A
Sbjct: 676 SDKFIYATVKQSSVDIYFRRQVELST---MYRHMEKHN----YESAAEAIQAVRDNKLHA 728
Query: 735 LLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMM 794
+ +S +E+ + C+L G L G+G+G SP++ ++++IL+ E G + +
Sbjct: 729 FIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDL 788
Query: 795 KEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQ 854
+ W R C N A+ L EN+ G+F+++A G+V +F+ E YK K+ +Q
Sbjct: 789 DKTWVRYQECDSRSNAPAT-LTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQ 847
Query: 855 C-LSFNAI 861
L+F A+
Sbjct: 848 MQLAFAAV 855
>gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]
Length = 901
Score = 260 bits (664), Expect = 5e-69
Identities = 235/908 (25%), Positives = 416/908 (45%), Gaps = 128/908 (14%)
Query: 20 ALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRN----RTLMPNT 75
ALL+ P+++ IG + T ++E + F+ AV N+ + + T
Sbjct: 10 ALLFSCSVARAACDPKIVNIGAVLSTRKHEQM------FREAVNQANKRHGSWKIQLNAT 63
Query: 76 TLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVP--HIQT 133
++T+ I + S + A+ V+ P+ + + V +P + T
Sbjct: 64 SVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTT 123
Query: 134 RWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDS----TGLIRLQEL 189
R S + L ++ P Y+ S +++ Y+W + ++ D RL+ L
Sbjct: 124 RMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETL 183
Query: 190 IKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMM 249
++ R + K+ Q G K+ LL E K+ + +I S + AA + + + M
Sbjct: 184 LE--ERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMT 241
Query: 250 TEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPE 309
Y + ++ L RY+ + G +L+N N
Sbjct: 242 GSGYVWLVGEREISGNAL---RYAPDGILGLQLINGKN---------------------- 276
Query: 310 TGLLDGMMTTEAALMYDAVYMVAIASHRASQ---LTVSSLQCHRHKP-WRLGPRFMNLIK 365
E+A + DAV +VA A H + +T C + W+ GP F ++
Sbjct: 277 ----------ESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLM 326
Query: 366 EARW-DGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNKD---- 420
+++ DG+TG + FN+ +G RK + I++L+ ++GI+N G ++ +++
Sbjct: 327 SSKYADGVTGRVEFNE-DGDRKFANYSIMNLQNRKLVQVGIYN---GTHVIPNDRKIIWP 382
Query: 421 --KSSNITDSLANRTLIVTTILEEPYVMYR--------KSDKPLYG-----------NDR 459
++ + L + TI +EP+V + K + + G ND
Sbjct: 383 GGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDT 442
Query: 460 FEG------------YCLDLLKELSNILGFIYDVKLVPDGKYGAQ-----NDKGEWNGMV 502
G +C+DLL +L+ + F Y+V LV DGK+G Q ++K EWNGM+
Sbjct: 443 SPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMM 502
Query: 503 KELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRK--PNGTNPGVFSFLNPLS 560
EL+ +AD+ VAPLTI R + I+FSKPF G++IL +K P T + SF+ P
Sbjct: 503 GELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRST---LDSFMQPFQ 559
Query: 561 PDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALM 620
+W+ V L+ V+ +L+++ RF+P+ + + + D + TL ++ WF G L+
Sbjct: 560 STLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDAL----TLSSAMWFSWGVLL 615
Query: 621 QQG-SELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQT- 678
G E P++ S RI+G +W F +II++SYTANLAAFL ++R E I +D +
Sbjct: 616 NSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNP 675
Query: 679 --KIEYGAVRDGSTMTFFKKS-KISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTD-YA 734
K Y V+ S +F++ ++ST M+ M ++ E IQ V +A
Sbjct: 676 SDKFIYATVKQSSVDIYFRRQVELST---MYRHMEKHN----YESAAEAIQAVRDNKLHA 728
Query: 735 LLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMM 794
+ +S +E+ + C+L G L G+G+G SP++ ++++IL+ E G + +
Sbjct: 729 FIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDL 788
Query: 795 KEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQ 854
+ W R C N A+ L EN+ G+F+++A G+V +F+ E YK K+ +Q
Sbjct: 789 DKTWVRYQECDSRSNAPAT-LTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQ 847
Query: 855 C-LSFNAI 861
L+F A+
Sbjct: 848 MQLAFAAV 855
>gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor
[Homo sapiens]
Length = 1484
Score = 190 bits (482), Expect = 6e-48
Identities = 143/493 (29%), Positives = 243/493 (49%), Gaps = 55/493 (11%)
Query: 392 IISLKEEGTEKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSD 451
I+ KE E++G W S L M + T+ + L + T+ E P+V+ D
Sbjct: 365 ILLNKERKWERVGKWKDKS-LQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVESVD 423
Query: 452 -------------------------KPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPD 486
+P Y +G+C+D+LK++S + F YD+ LV +
Sbjct: 424 PLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTN 483
Query: 487 GKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPN 546
GK+G + + G WNGM+ E++ RA +AV LTI R +V+DFS PF+ GIS++ + N
Sbjct: 484 GKHGKKIN-GTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSN 542
Query: 547 GT-NPGVFSFLNPLSPDIWMYVLLACLGVSCV-LFVIARFTPYEWYNPHPCNPDS-DVVE 603
GT +P +FL P S D+W+ + + L VS V +FV F+P + + C D +
Sbjct: 543 GTVSPS--AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGY---NRCLADGREPGG 597
Query: 604 NNFTLLNSFWFGVGALMQQGSELM-PKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVE 662
+FT+ + W G + + PK +++I+ +W FF +I ++SYTANLAAF+ E
Sbjct: 598 PSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQE 657
Query: 663 RMESPIDSADDLAKQ------TKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTA 716
+ D Q +G V +GST +++ + Y +M A+M Q
Sbjct: 658 EYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGST----ERNIRNNYAEMHAYMGKFNQ-- 711
Query: 717 LVRNSDEGIQRVLTTDY-ALLMESTSIEYVTQRN--CNLTQIGG--LIDSKGYGVGTPIG 771
R D+ + + T A + ++ + Y+ R+ C L IG + S GYG+
Sbjct: 712 --RGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKD 769
Query: 772 SPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGL 831
S ++ ++ +AILQL +G++ ++ W G E++ +S L ++N+ G+F +L A +
Sbjct: 770 SGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAM 829
Query: 832 VLSVFVAIGEFIY 844
LS+ I E ++
Sbjct: 830 ALSLITFICEHLF 842
>gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2
precursor [Homo sapiens]
Length = 1281
Score = 186 bits (471), Expect = 1e-46
Identities = 181/687 (26%), Positives = 310/687 (45%), Gaps = 98/687 (14%)
Query: 205 LPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFA 264
L + +DAK + ++KK ++ CS + A IL + +G+ Y +F+ L +
Sbjct: 206 LDTSFEDAKTQV-QLKKIHSSVILLYCSKDEAVLILSEARSLGLTG--YDFFWIVPSLVS 262
Query: 265 LDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALM 324
+ EL + +S + W L+A R G+L TT A+ M
Sbjct: 263 GNTELIPKE-----------FPSGLISVSYDDWDYS-LEARVRDGIGIL----TTAASSM 306
Query: 325 YDAV-YMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNG 383
+ Y+ + Q+ + H P+ + WDG T G
Sbjct: 307 LEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVN---------VTWDGKDLSFT---EEG 354
Query: 384 LRKDFDLDIISL-KEEGTEKIGIWNSNSGLNMTDSNKDKSSNITDSLANRT-LIVTTILE 441
+ L +I L K+ EK+G W +++ L++ + + + +D + L + T+ E
Sbjct: 355 YQVHPRLVVIVLNKDREWEKVGKWENHT-LSLRHAVWPRYKSFSDCEPDDNHLSIVTLEE 413
Query: 442 EPYVMYRKSDKPL----------------YGNDRFEG---------YCLDLLKELSNILG 476
P+V+ D PL N EG +C+D+LK+LS +
Sbjct: 414 APFVIVEDID-PLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVK 472
Query: 477 FIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTL 536
F YD+ LV +GK+G + + WNGM+ E++ RA +AV LTI R +V+DFS PF+
Sbjct: 473 FTYDLYLVTNGKHGKKVNN-VWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVET 531
Query: 537 GISILYRKPNGT-NPGVFSFLNPLSPDIWMYVLLACLGVSCV-LFVIARFTPYEWYNPH- 593
GIS++ + NGT +P +FL P S +W+ + + L VS + +FV F+P YN +
Sbjct: 532 GISVMVSRSNGTVSPS--AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVG-YNRNL 588
Query: 594 -----PCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM-PKALSTRIVGGIWWFFTLII 647
P P +FT+ + W G + + PK +++I+ +W FF +I
Sbjct: 589 AKGKAPHGP-------SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIF 641
Query: 648 ISSYTANLAAFLTVERMESPIDSADDLAKQTKIEY------GAVRDGSTMTFFKKSKIST 701
++SYTANLAAF+ E + D Q +Y G V +GST + +
Sbjct: 642 LASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYM 701
Query: 702 YEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRN--CNLTQIGG-- 757
++ M F + ALV + A + ++ + Y R+ C L IG
Sbjct: 702 HQYMTKFNQKGVEDALVSLKTGKLD-------AFIYDAAVLNYKAGRDEGCKLVTIGSGY 754
Query: 758 LIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGV 817
+ + GYG+ GSP++ +I +A+LQ +G++ ++ W G E++ +S L +
Sbjct: 755 IFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDI 814
Query: 818 ENIGGIFIVLAAGLVLSVFVAIGEFIY 844
+N+ G+F +LAA + LS+ I E ++
Sbjct: 815 DNMAGVFYMLAAAMALSLITFIWEHLF 841
>gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 186 bits (471), Expect = 1e-46
Identities = 181/687 (26%), Positives = 310/687 (45%), Gaps = 98/687 (14%)
Query: 205 LPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFA 264
L + +DAK + ++KK ++ CS + A IL + +G+ Y +F+ L +
Sbjct: 206 LDTSFEDAKTQV-QLKKIHSSVILLYCSKDEAVLILSEARSLGLTG--YDFFWIVPSLVS 262
Query: 265 LDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALM 324
+ EL + +S + W L+A R G+L TT A+ M
Sbjct: 263 GNTELIPKE-----------FPSGLISVSYDDWDYS-LEARVRDGIGIL----TTAASSM 306
Query: 325 YDAV-YMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNG 383
+ Y+ + Q+ + H P+ + WDG T G
Sbjct: 307 LEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVN---------VTWDGKDLSFT---EEG 354
Query: 384 LRKDFDLDIISL-KEEGTEKIGIWNSNSGLNMTDSNKDKSSNITDSLANRT-LIVTTILE 441
+ L +I L K+ EK+G W +++ L++ + + + +D + L + T+ E
Sbjct: 355 YQVHPRLVVIVLNKDREWEKVGKWENHT-LSLRHAVWPRYKSFSDCEPDDNHLSIVTLEE 413
Query: 442 EPYVMYRKSDKPL----------------YGNDRFEG---------YCLDLLKELSNILG 476
P+V+ D PL N EG +C+D+LK+LS +
Sbjct: 414 APFVIVEDID-PLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVK 472
Query: 477 FIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTL 536
F YD+ LV +GK+G + + WNGM+ E++ RA +AV LTI R +V+DFS PF+
Sbjct: 473 FTYDLYLVTNGKHGKKVNN-VWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVET 531
Query: 537 GISILYRKPNGT-NPGVFSFLNPLSPDIWMYVLLACLGVSCV-LFVIARFTPYEWYNPH- 593
GIS++ + NGT +P +FL P S +W+ + + L VS + +FV F+P YN +
Sbjct: 532 GISVMVSRSNGTVSPS--AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVG-YNRNL 588
Query: 594 -----PCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM-PKALSTRIVGGIWWFFTLII 647
P P +FT+ + W G + + PK +++I+ +W FF +I
Sbjct: 589 AKGKAPHGP-------SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIF 641
Query: 648 ISSYTANLAAFLTVERMESPIDSADDLAKQTKIEY------GAVRDGSTMTFFKKSKIST 701
++SYTANLAAF+ E + D Q +Y G V +GST + +
Sbjct: 642 LASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYM 701
Query: 702 YEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRN--CNLTQIGG-- 757
++ M F + ALV + A + ++ + Y R+ C L IG
Sbjct: 702 HQYMTKFNQKGVEDALVSLKTGKLD-------AFIYDAAVLNYKAGRDEGCKLVTIGSGY 754
Query: 758 LIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGV 817
+ + GYG+ GSP++ +I +A+LQ +G++ ++ W G E++ +S L +
Sbjct: 755 IFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDI 814
Query: 818 ENIGGIFIVLAAGLVLSVFVAIGEFIY 844
+N+ G+F +LAA + LS+ I E ++
Sbjct: 815 DNMAGVFYMLAAAMALSLITFIWEHLF 841
>gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 186 bits (471), Expect = 1e-46
Identities = 181/687 (26%), Positives = 310/687 (45%), Gaps = 98/687 (14%)
Query: 205 LPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFA 264
L + +DAK + ++KK ++ CS + A IL + +G+ Y +F+ L +
Sbjct: 206 LDTSFEDAKTQV-QLKKIHSSVILLYCSKDEAVLILSEARSLGLTG--YDFFWIVPSLVS 262
Query: 265 LDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALM 324
+ EL + +S + W L+A R G+L TT A+ M
Sbjct: 263 GNTELIPKE-----------FPSGLISVSYDDWDYS-LEARVRDGIGIL----TTAASSM 306
Query: 325 YDAV-YMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNG 383
+ Y+ + Q+ + H P+ + WDG T G
Sbjct: 307 LEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVN---------VTWDGKDLSFT---EEG 354
Query: 384 LRKDFDLDIISL-KEEGTEKIGIWNSNSGLNMTDSNKDKSSNITDSLANRT-LIVTTILE 441
+ L +I L K+ EK+G W +++ L++ + + + +D + L + T+ E
Sbjct: 355 YQVHPRLVVIVLNKDREWEKVGKWENHT-LSLRHAVWPRYKSFSDCEPDDNHLSIVTLEE 413
Query: 442 EPYVMYRKSDKPL----------------YGNDRFEG---------YCLDLLKELSNILG 476
P+V+ D PL N EG +C+D+LK+LS +
Sbjct: 414 APFVIVEDID-PLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVK 472
Query: 477 FIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTL 536
F YD+ LV +GK+G + + WNGM+ E++ RA +AV LTI R +V+DFS PF+
Sbjct: 473 FTYDLYLVTNGKHGKKVNN-VWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVET 531
Query: 537 GISILYRKPNGT-NPGVFSFLNPLSPDIWMYVLLACLGVSCV-LFVIARFTPYEWYNPH- 593
GIS++ + NGT +P +FL P S +W+ + + L VS + +FV F+P YN +
Sbjct: 532 GISVMVSRSNGTVSPS--AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVG-YNRNL 588
Query: 594 -----PCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM-PKALSTRIVGGIWWFFTLII 647
P P +FT+ + W G + + PK +++I+ +W FF +I
Sbjct: 589 AKGKAPHGP-------SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIF 641
Query: 648 ISSYTANLAAFLTVERMESPIDSADDLAKQTKIEY------GAVRDGSTMTFFKKSKIST 701
++SYTANLAAF+ E + D Q +Y G V +GST + +
Sbjct: 642 LASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYM 701
Query: 702 YEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRN--CNLTQIGG-- 757
++ M F + ALV + A + ++ + Y R+ C L IG
Sbjct: 702 HQYMTKFNQKGVEDALVSLKTGKLD-------AFIYDAAVLNYKAGRDEGCKLVTIGSGY 754
Query: 758 LIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGV 817
+ + GYG+ GSP++ +I +A+LQ +G++ ++ W G E++ +S L +
Sbjct: 755 IFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDI 814
Query: 818 ENIGGIFIVLAAGLVLSVFVAIGEFIY 844
+N+ G+F +LAA + LS+ I E ++
Sbjct: 815 DNMAGVFYMLAAAMALSLITFIWEHLF 841
>gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor
[Homo sapiens]
Length = 1336
Score = 179 bits (453), Expect = 1e-44
Identities = 122/401 (30%), Positives = 209/401 (52%), Gaps = 35/401 (8%)
Query: 461 EGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTIT 520
+G+C+D+LK L++ +GF YD+ LV +GK+G + D G WNGM+ E+ RAD+A+ LTI
Sbjct: 485 KGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKID-GVWNGMIGEVFYQRADMAIGSLTIN 543
Query: 521 YVREKVIDFSKPFMTLGISILYRKPNGT-NPGVFSFLNPLSPDIWMYVLLACLGVSCVLF 579
R +++DFS PF+ GIS++ + NGT +P +FL P SP +W+ + + CL V V
Sbjct: 544 EERSEIVDFSVPFVETGISVMVARSNGTVSPS--AFLEPYSPAVWVMMFVMCLTVVAVTV 601
Query: 580 VIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM--PKALSTRIVG 637
I + YN + FT+ S W + AL+ S + P+ +++I+
Sbjct: 602 FIFEYLSPVGYN-RSLATGKRPGGSTFTIGKSIWL-LWALVFNNSVPVENPRGTTSKIMV 659
Query: 638 GIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQ------TKIEYGAVRDGSTM 691
+W FF +I ++SYTANLAAF+ E + D Q +++G V +GST
Sbjct: 660 LVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGST- 718
Query: 692 TFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDY-----ALLMESTSIEYVT 746
+K+ S Y M ++M VR + ++ LT A + ++ + Y+
Sbjct: 719 ---EKNIRSNYPDMHSYM--------VRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMA 767
Query: 747 QRN--CNLTQIGG--LIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGN 802
+++ C L IG + + GYG+ GS ++ I +A+LQ + ++ M++ W G
Sbjct: 768 RKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGI 827
Query: 803 GCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFI 843
++ +S L ++N+ G+F +L + LS+ V E +
Sbjct: 828 CHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHL 868
>gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor
[Homo sapiens]
Length = 1233
Score = 171 bits (433), Expect = 3e-42
Identities = 130/464 (28%), Positives = 232/464 (50%), Gaps = 70/464 (15%)
Query: 422 SSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYG------------NDRF--------- 460
S+++ + +R L V T+ E P+V+ D G N F
Sbjct: 391 SASLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDVAPYT 450
Query: 461 ----EGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAP 516
+G+C+D+LK+L+ ++ F YD+ LV +GK+G + +G WNGM+ E+ RAD+A+
Sbjct: 451 KLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHG-KRVRGVWNGMIGEVYYKRADMAIGS 509
Query: 517 LTITYVREKVIDFSKPFMTLGISILYRKPNGT-NPGVFSFLNPLSPDIWMYVLLACLGVS 575
LTI R +++DFS PF+ GIS++ + NGT +P +FL P SP +W+ + + CL V
Sbjct: 510 LTINEERSEIVDFSVPFVETGISVMVARSNGTVSPS--AFLEPYSPAVWVMMFVMCLTVV 567
Query: 576 CVLFVIARFTPYEWYNPHPCNPDSDVVENN----FTLLNSFWFGVGALMQQGSELM--PK 629
+ + +E+++P N + + + FT+ S W + AL+ S + P+
Sbjct: 568 AITVFM-----FEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWL-LWALVFNNSVPIENPR 621
Query: 630 ALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTK------IEYG 683
+++I+ +W FF +I ++SYTANLAAF+ E+ + D Q +G
Sbjct: 622 GTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFG 681
Query: 684 AVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDY-----ALLME 738
V +GST +++ S Y M T +V+ + ++ LT+ A + +
Sbjct: 682 TVPNGST----ERNIRSNYRDM--------HTHMVKFNQRSVEDALTSLKMGKLDAFIYD 729
Query: 739 STSIEYVTQRN--CNLTQIGG--LIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMM 794
+ + Y+ ++ C L IG + + GYG+ S ++ I +A+LQ +G+ +
Sbjct: 730 AAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKL 789
Query: 795 KEKWWRGNGCPEEDNKEASALGVENIGGIF--IVLAAGLVLSVF 836
+ W G E++ +S L ++N+ G+F +++A GL L VF
Sbjct: 790 ETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVF 833
>gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartate
3A [Homo sapiens]
Length = 1115
Score = 162 bits (409), Expect = 2e-39
Identities = 112/391 (28%), Positives = 189/391 (48%), Gaps = 23/391 (5%)
Query: 462 GYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITY 521
GYC+DLL++++ + F +D+ +V DGKYGA + G W G+V +L+ A +AV +I
Sbjct: 578 GYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWKN-GHWTGLVGDLLRGTAHMAVTSFSINT 636
Query: 522 VREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVI 581
R +VIDF+ PF + + IL R + P + +F+ PL +W LG+ L +
Sbjct: 637 ARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMW-------LGIFVALHIT 688
Query: 582 ARF-TPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM-PKALSTRIVGGI 639
A F T YEW +P P F+ ++ L + + PK + R + +
Sbjct: 689 AVFLTLYEWKSPFGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNL 748
Query: 640 WWFFTLIIISSYTANLAAFLTVERMESPIDSADDLA---KQTKIEYGAVRDGSTMTFFKK 696
W F + +S+YTANLAA + E++ + D +G VR+ S + ++
Sbjct: 749 WAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQ 808
Query: 697 S--KISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQ 754
S ++ Y + + ++ ++N E + + D ALL SI+ +C L
Sbjct: 809 SFPEMHEYMRRYNVPATPDGVEYLKNDPEKLDAFI-MDKALLDYEVSID----ADCKLLT 863
Query: 755 IGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEED--NKEA 812
+G +GYG+G P SP I+ I Q + G + M+ +KW+R C + E
Sbjct: 864 VGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVTET 923
Query: 813 SALGVENIGGIFIVLAAGLVLSVFVAIGEFI 843
+G+++ G+F++L G LS+ IGE I
Sbjct: 924 LQMGIKHFSGLFVLLCIGFGLSILTTIGEHI 954
>gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
[Homo sapiens]
Length = 1043
Score = 153 bits (387), Expect = 6e-37
Identities = 110/396 (27%), Positives = 189/396 (47%), Gaps = 31/396 (7%)
Query: 462 GYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITY 521
GYC+DLL+ L+ F +++ LV DGKYGA D G W G+V +L+ RA +AV +I
Sbjct: 478 GYCIDLLERLAEDTPFDFELYLVGDGKYGALRD-GRWTGLVGDLLAGRAHMAVTSFSINS 536
Query: 522 VREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVI 581
R +V+DF+ PF + + I+ R + +P + +F+ PL W LGV L +
Sbjct: 537 ARSQVVDFTSPFFSTSLGIMVRARDTASP-IGAFMWPLHWSTW-------LGVFAALHLT 588
Query: 582 ARF-TPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQG-SELMPKALSTRIVGGI 639
A F T YEW +P+ P F+ ++ L ++ S PK + R++ +
Sbjct: 589 ALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCPTGRLLMNL 648
Query: 640 WWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIE---YGAVRDGSTMTFFKK 696
W F L+++SSYTANLAA + ++ + D + +G V + S + KK
Sbjct: 649 WAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYIKK 708
Query: 697 SKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTD----YALLMESTSIEYVT--QRNC 750
S + M A M R +LT+D A +M+ + ++Y +C
Sbjct: 709 S----FPDMHAHMRRHSAPTTPRG-----VAMLTSDPPKLNAFIMDKSLLDYEVSIDADC 759
Query: 751 NLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEE--D 808
L +G +GYG+G P SP ++ I + + G + ++ +KW++ C +
Sbjct: 760 KLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFA 819
Query: 809 NKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIY 844
E + + + G+F++L GL ++ ++GE +
Sbjct: 820 VTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAF 855
>gi|116284390 glutamate receptor, ionotrophic, AMPA 4 isoform 3
precursor [Homo sapiens]
Length = 433
Score = 145 bits (366), Expect = 2e-34
Identities = 110/416 (26%), Positives = 190/416 (45%), Gaps = 25/416 (6%)
Query: 34 PQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEAS 93
P ++IGG+F ++ LA TS N + L + I +SF +
Sbjct: 24 PSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPF---NLVPHVDNIETANSFAVT 80
Query: 94 RRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDLFYINLYPD 153
C Q + GV A+FG SV + S C+AL + I + + + F + L P
Sbjct: 81 NAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFP---TEGESQFVLQLRP- 136
Query: 154 YAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDA- 212
++ A+L L+ +Y W +Y+ G LQ +++ + + + + N +
Sbjct: 137 --SLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSY 194
Query: 213 KPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRY 272
+ LL+E+ + +E + DC E IL+QI+ +G + YHY L + LE + +
Sbjct: 195 RQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIH 254
Query: 273 SGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDAVYMVA 332
G N+TGF+L++ + P V ++++W + P ET +AL YD V ++A
Sbjct: 255 GGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSET-----PPKYTSALTYDGVLVMA 309
Query: 333 --IASHRASQLTVS------SLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNGL 384
S R ++ +S + PW G +K+ R GLTG++ F+ G
Sbjct: 310 ETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDH-YGR 368
Query: 385 RKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTIL 440
R ++ +D+ LK G K+G WN L + + N T ++ NRT++VTTI+
Sbjct: 369 RVNYTMDVFELKSTGPRKVGYWNDMDKLVLI-QDVPTLGNDTAAIENRTVVVTTIM 423
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,455,570
Number of Sequences: 37866
Number of extensions: 1402798
Number of successful extensions: 3408
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 3173
Number of HSP's gapped (non-prelim): 70
length of query: 905
length of database: 18,247,518
effective HSP length: 111
effective length of query: 794
effective length of database: 14,044,392
effective search space: 11151247248
effective search space used: 11151247248
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.