Guide to the Human Genome
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Search of human proteins with 27886590

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a
[Homo sapiens]
         (1009 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo...  2043   0.0  
gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo...  2043   0.0  
gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo...  2043   0.0  
gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo...  1933   0.0  
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]   824   0.0  
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]   824   0.0  
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]     232   1e-60
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...   215   1e-55
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...   215   1e-55
gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo...   214   3e-55
gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo...   213   6e-55
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]             211   3e-54
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]               211   3e-54
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]             211   3e-54
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]             211   3e-54
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]             211   3e-54
gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]             211   3e-54
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo...   208   2e-53
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]     206   7e-53
gi|54792098 erbB-2 isoform b [Homo sapiens]                           204   3e-52
gi|54792096 erbB-2 isoform a [Homo sapiens]                           204   3e-52
gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo sap...   204   3e-52
gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo sapi...   204   3e-52
gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo sap...   204   3e-52
gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo sap...   204   3e-52
gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo sapi...   204   3e-52
gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]         204   4e-52
gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]         204   4e-52
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]         204   4e-52
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]           204   4e-52

>gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
            sapiens]
          Length = 1009

 Score = 2043 bits (5292), Expect = 0.0
 Identities = 1009/1009 (100%), Positives = 1009/1009 (100%)

Query: 1    MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVK 60
            MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVK
Sbjct: 1    MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVK 60

Query: 61   CTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYEC 120
            CTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYEC
Sbjct: 61   CTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYEC 120

Query: 121  LHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGC 180
            LHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGC
Sbjct: 121  LHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGC 180

Query: 181  LELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYAS 240
            LELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYAS
Sbjct: 181  LELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYAS 240

Query: 241  LREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLA 300
            LREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLA
Sbjct: 241  LREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLA 300

Query: 301  EFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQG 360
            EFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQG
Sbjct: 301  EFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQG 360

Query: 361  SLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGI 420
            SLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGI
Sbjct: 361  SLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGI 420

Query: 421  AREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKN 480
            AREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKN
Sbjct: 421  AREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKN 480

Query: 481  LDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL 540
            LDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL
Sbjct: 481  LDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL 540

Query: 541  ESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFR 600
            ESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFR
Sbjct: 541  ESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFR 600

Query: 601  RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTR 660
            RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTR
Sbjct: 601  RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTR 660

Query: 661  CWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRP 720
            CWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRP
Sbjct: 661  CWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRP 720

Query: 721  KYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMR 780
            KYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMR
Sbjct: 721  KYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMR 780

Query: 781  EEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSP 840
            EEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSP
Sbjct: 781  EEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSP 840

Query: 841  LTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQ 900
            LTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQ
Sbjct: 841  LTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQ 900

Query: 901  LPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLA 960
            LPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLA
Sbjct: 901  LPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLA 960

Query: 961  QQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE 1009
            QQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE
Sbjct: 961  QQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE 1009


>gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
            sapiens]
          Length = 1009

 Score = 2043 bits (5292), Expect = 0.0
 Identities = 1009/1009 (100%), Positives = 1009/1009 (100%)

Query: 1    MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVK 60
            MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVK
Sbjct: 1    MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVK 60

Query: 61   CTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYEC 120
            CTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYEC
Sbjct: 61   CTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYEC 120

Query: 121  LHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGC 180
            LHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGC
Sbjct: 121  LHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGC 180

Query: 181  LELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYAS 240
            LELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYAS
Sbjct: 181  LELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYAS 240

Query: 241  LREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLA 300
            LREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLA
Sbjct: 241  LREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLA 300

Query: 301  EFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQG 360
            EFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQG
Sbjct: 301  EFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQG 360

Query: 361  SLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGI 420
            SLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGI
Sbjct: 361  SLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGI 420

Query: 421  AREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKN 480
            AREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKN
Sbjct: 421  AREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKN 480

Query: 481  LDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL 540
            LDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL
Sbjct: 481  LDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL 540

Query: 541  ESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFR 600
            ESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFR
Sbjct: 541  ESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFR 600

Query: 601  RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTR 660
            RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTR
Sbjct: 601  RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTR 660

Query: 661  CWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRP 720
            CWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRP
Sbjct: 661  CWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRP 720

Query: 721  KYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMR 780
            KYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMR
Sbjct: 721  KYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMR 780

Query: 781  EEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSP 840
            EEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSP
Sbjct: 781  EEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSP 840

Query: 841  LTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQ 900
            LTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQ
Sbjct: 841  LTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQ 900

Query: 901  LPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLA 960
            LPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLA
Sbjct: 901  LPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLA 960

Query: 961  QQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE 1009
            QQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE
Sbjct: 961  QQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE 1009


>gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
            sapiens]
          Length = 1009

 Score = 2043 bits (5292), Expect = 0.0
 Identities = 1009/1009 (100%), Positives = 1009/1009 (100%)

Query: 1    MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVK 60
            MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVK
Sbjct: 1    MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVK 60

Query: 61   CTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYEC 120
            CTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYEC
Sbjct: 61   CTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYEC 120

Query: 121  LHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGC 180
            LHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGC
Sbjct: 121  LHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGC 180

Query: 181  LELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYAS 240
            LELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYAS
Sbjct: 181  LELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYAS 240

Query: 241  LREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLA 300
            LREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLA
Sbjct: 241  LREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLA 300

Query: 301  EFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQG 360
            EFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQG
Sbjct: 301  EFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQG 360

Query: 361  SLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGI 420
            SLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGI
Sbjct: 361  SLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGI 420

Query: 421  AREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKN 480
            AREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKN
Sbjct: 421  AREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKN 480

Query: 481  LDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL 540
            LDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL
Sbjct: 481  LDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL 540

Query: 541  ESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFR 600
            ESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFR
Sbjct: 541  ESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFR 600

Query: 601  RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTR 660
            RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTR
Sbjct: 601  RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTR 660

Query: 661  CWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRP 720
            CWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRP
Sbjct: 661  CWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRP 720

Query: 721  KYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMR 780
            KYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMR
Sbjct: 721  KYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMR 780

Query: 781  EEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSP 840
            EEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSP
Sbjct: 781  EEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSP 840

Query: 841  LTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQ 900
            LTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQ
Sbjct: 841  LTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQ 900

Query: 901  LPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLA 960
            LPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLA
Sbjct: 901  LPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLA 960

Query: 961  QQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE 1009
            QQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE
Sbjct: 961  QQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE 1009


>gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo
            sapiens]
          Length = 967

 Score = 1933 bits (5007), Expect = 0.0
 Identities = 967/1009 (95%), Positives = 967/1009 (95%), Gaps = 42/1009 (4%)

Query: 1    MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVK 60
            MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVK
Sbjct: 1    MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVK 60

Query: 61   CTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYEC 120
            CTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYEC
Sbjct: 61   CTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYEC 120

Query: 121  LHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGC 180
            LHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGC
Sbjct: 121  LHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGC 180

Query: 181  LELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYAS 240
            LELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYAS
Sbjct: 181  LELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYAS 240

Query: 241  LREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLA 300
            LREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLA
Sbjct: 241  LREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLA 300

Query: 301  EFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQG 360
            EFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQG
Sbjct: 301  EFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQG 360

Query: 361  SLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGI 420
            SLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGI
Sbjct: 361  SLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGI 420

Query: 421  AREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKN 480
            AREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKN
Sbjct: 421  AREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKN 480

Query: 481  LDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL 540
            LDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL
Sbjct: 481  LDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL 540

Query: 541  ESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFR 600
            ESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFR
Sbjct: 541  ESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFR 600

Query: 601  RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTR 660
            RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTR
Sbjct: 601  RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTR 660

Query: 661  CWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRP 720
            CWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRP
Sbjct: 661  CWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRP 720

Query: 721  KYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMR 780
            KYRPPPQTNLLAPKLQFQ                                          
Sbjct: 721  KYRPPPQTNLLAPKLQFQ------------------------------------------ 738

Query: 781  EEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSP 840
            EEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSP
Sbjct: 739  EEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSP 798

Query: 841  LTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQ 900
            LTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQ
Sbjct: 799  LTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQ 858

Query: 901  LPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLA 960
            LPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLA
Sbjct: 859  LPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLA 918

Query: 961  QQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE 1009
            QQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE
Sbjct: 919  QQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE 967


>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
          Length = 1074

 Score =  824 bits (2128), Expect = 0.0
 Identities = 473/1022 (46%), Positives = 637/1022 (62%), Gaps = 74/1022 (7%)

Query: 39   RILKVCFY--SNSFNPGKNFKLVKCTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKH 96
            R+LKV  Y  SNS  P     +++    T++R II  I+ S ++    +   CYG RL H
Sbjct: 57   RVLKVFHYFESNS-EPTTWASIIRHGDATDVRGIIQKIVDSHKV----KHVACYGFRLSH 111

Query: 97   MKSDEIHWLHPQMTVGEVQDKYECLHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQ 156
            ++S+E+HWLH  M V  V++KYE  H   EW+Y+L+IRYLP+ F+    ED+ TL +FYQ
Sbjct: 112  LRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQ 171

Query: 157  QLRNDYMQRYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPK 216
            Q+++DYM   A +V + +AL+LGCLE+RR + +M  NAL+KKSN+E+LEK+VGL  FFPK
Sbjct: 172  QVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPK 231

Query: 217  QMQENLKPKQFRKMIQQTFQQYASLREEECVMKFFNTLAGFANIDQETYRCELIQGWNIT 276
             + +++K K  RK+IQQTF+Q+A+L  EE ++KFF  L+     D+E ++C L   W I+
Sbjct: 232  SLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIIS 291

Query: 277  VDLVIGPK-GIRQLTSQDAKPTCLAEFKQIRSIRCLPLEEG--QAVLQLGIEGAPQALSI 333
            V+L IGP+ GI  LT +   PT LA+F Q+++I+    E+   + +LQL I GAP+ L++
Sbjct: 292  VELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTV 351

Query: 334  KTSSLAEAENMADLIDGYCRLQGEHQGSLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSE 393
               SL  AENMADLIDGYCRL      S II P+K+GE+  +LP IP L    ++   + 
Sbjct: 352  TAPSLTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGER--ALPSIPKLANSEKQGMRTH 409

Query: 394  SCSI-ESDIYAEIPDE--TLRRPGGPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGE 450
            + S+ E+D YAEI DE  T   P    Y I RE + L R +GEG FG+V++G+Y + +  
Sbjct: 410  AVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENP 469

Query: 451  KINVAVKTCKKDCTLDN-KEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGE 509
             + VA+KTCK +CT D+ +EKF+ EA+ M+  DHPHIVKLIG+I E P WIIMEL   GE
Sbjct: 470  ALAVAIKTCK-NCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGE 528

Query: 510  LGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFG 569
            L  +L+  K SL + +L+LY+ Q+  A+AYLES   VHRDIA RN+LV+S +CVKLGDFG
Sbjct: 529  LRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFG 588

Query: 570  LSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWL 629
            LSRY+ED  YYKAS  +LPIKWM+PESINFRRFT+ASDVWMF VCMWEIL  G +PF  +
Sbjct: 589  LSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGV 648

Query: 630  ENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQMEKDI 689
            +N DVIG +E G+RLP P  CPP LY+LMT+CW YDPS RPRFTEL   LS + + EK  
Sbjct: 649  KNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEK-- 706

Query: 690  AMEQER---NARYRTPKILEPTAFQEPPPKPSRPKYRPPPQTNLLAPKLQ-------FQV 739
            A ++ER    +R +     +     E PPKPSRP Y  P  +    P  Q       +QV
Sbjct: 707  AQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQV 766

Query: 740  PEGLCASSPTLTSPMEYPSPVNSLHTPPL--HRHNVFKRHSMREEDFIQPSSREEAQQLW 797
                 +   T  +   YP   + L       HR           ED      R   Q L 
Sbjct: 767  SGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVL- 825

Query: 798  EAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKS----------PLTPE--- 844
                  M + L +QQ++M ED +WL +EE+ L P V ++  S          P+  +   
Sbjct: 826  --PTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIY 883

Query: 845  KEVGYLEFTGPPQKPPRLGAQ---------------------------SIQPTANLDRTD 877
            + VG  +   PP+KPPR GA                            S  PTANLDR++
Sbjct: 884  QPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSN 943

Query: 878  DLVYLNVMELVRAVLELKNELCQLPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRT 937
            D VY NV  LV+AV+E+ +++   PPE YV +VK VGL LR L+ +VD+ +P LP+S+  
Sbjct: 944  DKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHR 1003

Query: 938  EIEGTQKLLNKDLAELINKMRLAQQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQA 997
            EIE  QKLLN DL ELINKM+LAQQ  +TSL +E K+QMLTA+H LAVDAKNLLD +DQA
Sbjct: 1004 EIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQA 1063

Query: 998  KV 999
            ++
Sbjct: 1064 RL 1065


>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
          Length = 1052

 Score =  824 bits (2128), Expect = 0.0
 Identities = 473/1022 (46%), Positives = 637/1022 (62%), Gaps = 74/1022 (7%)

Query: 39   RILKVCFY--SNSFNPGKNFKLVKCTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKH 96
            R+LKV  Y  SNS  P     +++    T++R II  I+ S ++    +   CYG RL H
Sbjct: 35   RVLKVFHYFESNS-EPTTWASIIRHGDATDVRGIIQKIVDSHKV----KHVACYGFRLSH 89

Query: 97   MKSDEIHWLHPQMTVGEVQDKYECLHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQ 156
            ++S+E+HWLH  M V  V++KYE  H   EW+Y+L+IRYLP+ F+    ED+ TL +FYQ
Sbjct: 90   LRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQ 149

Query: 157  QLRNDYMQRYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPK 216
            Q+++DYM   A +V + +AL+LGCLE+RR + +M  NAL+KKSN+E+LEK+VGL  FFPK
Sbjct: 150  QVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPK 209

Query: 217  QMQENLKPKQFRKMIQQTFQQYASLREEECVMKFFNTLAGFANIDQETYRCELIQGWNIT 276
             + +++K K  RK+IQQTF+Q+A+L  EE ++KFF  L+     D+E ++C L   W I+
Sbjct: 210  SLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIIS 269

Query: 277  VDLVIGPK-GIRQLTSQDAKPTCLAEFKQIRSIRCLPLEEG--QAVLQLGIEGAPQALSI 333
            V+L IGP+ GI  LT +   PT LA+F Q+++I+    E+   + +LQL I GAP+ L++
Sbjct: 270  VELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTV 329

Query: 334  KTSSLAEAENMADLIDGYCRLQGEHQGSLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSE 393
               SL  AENMADLIDGYCRL      S II P+K+GE+  +LP IP L    ++   + 
Sbjct: 330  TAPSLTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGER--ALPSIPKLANSEKQGMRTH 387

Query: 394  SCSI-ESDIYAEIPDE--TLRRPGGPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGE 450
            + S+ E+D YAEI DE  T   P    Y I RE + L R +GEG FG+V++G+Y + +  
Sbjct: 388  AVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENP 447

Query: 451  KINVAVKTCKKDCTLDN-KEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGE 509
             + VA+KTCK +CT D+ +EKF+ EA+ M+  DHPHIVKLIG+I E P WIIMEL   GE
Sbjct: 448  ALAVAIKTCK-NCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGE 506

Query: 510  LGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFG 569
            L  +L+  K SL + +L+LY+ Q+  A+AYLES   VHRDIA RN+LV+S +CVKLGDFG
Sbjct: 507  LRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFG 566

Query: 570  LSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWL 629
            LSRY+ED  YYKAS  +LPIKWM+PESINFRRFT+ASDVWMF VCMWEIL  G +PF  +
Sbjct: 567  LSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGV 626

Query: 630  ENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQMEKDI 689
            +N DVIG +E G+RLP P  CPP LY+LMT+CW YDPS RPRFTEL   LS + + EK  
Sbjct: 627  KNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEK-- 684

Query: 690  AMEQER---NARYRTPKILEPTAFQEPPPKPSRPKYRPPPQTNLLAPKLQ-------FQV 739
            A ++ER    +R +     +     E PPKPSRP Y  P  +    P  Q       +QV
Sbjct: 685  AQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQV 744

Query: 740  PEGLCASSPTLTSPMEYPSPVNSLHTPPL--HRHNVFKRHSMREEDFIQPSSREEAQQLW 797
                 +   T  +   YP   + L       HR           ED      R   Q L 
Sbjct: 745  SGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVL- 803

Query: 798  EAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKS----------PLTPE--- 844
                  M + L +QQ++M ED +WL +EE+ L P V ++  S          P+  +   
Sbjct: 804  --PTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIY 861

Query: 845  KEVGYLEFTGPPQKPPRLGAQ---------------------------SIQPTANLDRTD 877
            + VG  +   PP+KPPR GA                            S  PTANLDR++
Sbjct: 862  QPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSN 921

Query: 878  DLVYLNVMELVRAVLELKNELCQLPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRT 937
            D VY NV  LV+AV+E+ +++   PPE YV +VK VGL LR L+ +VD+ +P LP+S+  
Sbjct: 922  DKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHR 981

Query: 938  EIEGTQKLLNKDLAELINKMRLAQQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQA 997
            EIE  QKLLN DL ELINKM+LAQQ  +TSL +E K+QMLTA+H LAVDAKNLLD +DQA
Sbjct: 982  EIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQA 1041

Query: 998  KV 999
            ++
Sbjct: 1042 RL 1043


>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
          Length = 822

 Score =  232 bits (592), Expect = 1e-60
 Identities = 113/264 (42%), Positives = 168/264 (63%), Gaps = 5/264 (1%)

Query: 413 PGGPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFM 472
           P   ++ ++ EDV+L  +LG+G FGEVY+G       +K +VAVKTCK+D   + K KF+
Sbjct: 551 PKDKKWILSHEDVILGELLGKGNFGEVYKGTLK----DKTSVAVKTCKEDLPQELKIKFL 606

Query: 473 SEAVIMKNLDHPHIVKLIGII-EEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSL 531
            EA I+K  DHP+IVKLIG+  + +P +IIMEL   G+   +L R K+ LK+  LV +SL
Sbjct: 607 QEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSL 666

Query: 532 QICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKW 591
                M YLES NC+HRD+A RN LV     +K+ DFG+SR  +   Y  + + ++PIKW
Sbjct: 667 DAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKW 726

Query: 592 MSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCP 651
            +PE++N+ R+++ SDVW F + +WE  S G  P+  + N+     +E+G R+  P  CP
Sbjct: 727 TAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCP 786

Query: 652 PVLYTLMTRCWDYDPSDRPRFTEL 675
             +  +M +CWDY P +RP+F+EL
Sbjct: 787 EDISKIMMKCWDYKPENRPKFSEL 810


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score =  215 bits (548), Expect = 1e-55
 Identities = 116/303 (38%), Positives = 174/303 (57%), Gaps = 8/303 (2%)

Query: 413 PGGPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFM 472
           P   ++ + R D+ +   LG G +GEVYEGV+  +    + VAVKT K+D      E+F+
Sbjct: 230 PNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYS---LTVAVKTLKEDTM--EVEEFL 284

Query: 473 SEAVIMKNLDHPHIVKLIGIIEEEPT-WIIMELYPYGELGHYL-ERNKNSLKVLTLVLYS 530
            EA +MK + HP++V+L+G+   EP  +II E   YG L  YL E N+  +  + L+  +
Sbjct: 285 KEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMA 344

Query: 531 LQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIK 590
            QI  AM YLE  N +HRD+A RN LV     VK+ DFGLSR +  + Y   +  + PIK
Sbjct: 345 TQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIK 404

Query: 591 WMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLC 650
           W +PES+ + +F+  SDVW F V +WEI ++G  P+  ++   V  +LEK  R+ +P+ C
Sbjct: 405 WTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGC 464

Query: 651 PPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAF 710
           P  +Y LM  CW ++PSDRP F E+  +   ++Q E  I+ E E+    +  +    T  
Sbjct: 465 PEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ-ESSISDEVEKELGKQGVRGAVSTLL 523

Query: 711 QEP 713
           Q P
Sbjct: 524 QAP 526


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score =  215 bits (548), Expect = 1e-55
 Identities = 116/303 (38%), Positives = 174/303 (57%), Gaps = 8/303 (2%)

Query: 413 PGGPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFM 472
           P   ++ + R D+ +   LG G +GEVYEGV+  +    + VAVKT K+D      E+F+
Sbjct: 249 PNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYS---LTVAVKTLKEDTM--EVEEFL 303

Query: 473 SEAVIMKNLDHPHIVKLIGIIEEEPT-WIIMELYPYGELGHYL-ERNKNSLKVLTLVLYS 530
            EA +MK + HP++V+L+G+   EP  +II E   YG L  YL E N+  +  + L+  +
Sbjct: 304 KEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMA 363

Query: 531 LQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIK 590
            QI  AM YLE  N +HRD+A RN LV     VK+ DFGLSR +  + Y   +  + PIK
Sbjct: 364 TQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIK 423

Query: 591 WMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLC 650
           W +PES+ + +F+  SDVW F V +WEI ++G  P+  ++   V  +LEK  R+ +P+ C
Sbjct: 424 WTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGC 483

Query: 651 PPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAF 710
           P  +Y LM  CW ++PSDRP F E+  +   ++Q E  I+ E E+    +  +    T  
Sbjct: 484 PEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ-ESSISDEVEKELGKQGVRGAVSTLL 542

Query: 711 QEP 713
           Q P
Sbjct: 543 QAP 545


>gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4
            isoform JM-a/CVT-1 precursor [Homo sapiens]
          Length = 1308

 Score =  214 bits (546), Expect = 3e-55
 Identities = 125/376 (33%), Positives = 203/376 (53%), Gaps = 40/376 (10%)

Query: 429  RILGEGFFGEVYEGVYTNHKGE--KINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHI 486
            ++LG G FG VY+G++   +GE  KI VA+K   +        +FM EA+IM ++DHPH+
Sbjct: 722  KVLGSGAFGTVYKGIWVP-EGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL 780

Query: 487  VKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCV 546
            V+L+G+       ++ +L P+G L  Y+  +K+++    L+ + +QI K M YLE    V
Sbjct: 781  VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840

Query: 547  HRDIAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVTRLPIKWMSPESINFRRFTTA 605
            HRD+A RN+LV SP  VK+ DFGL+R +E DE  Y A   ++PIKWM+ E I++R+FT  
Sbjct: 841  HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ 900

Query: 606  SDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYD 665
            SDVW + V +WE+++FG +P+  +  +++  +LEKG+RLP+P +C   +Y +M +CW  D
Sbjct: 901  SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID 960

Query: 666  PSDRPRFTELVCSLSDV-----------------------YQMEKDIAMEQERNARYRTP 702
               RP+F EL    S +                        +  +++  E++        
Sbjct: 961  ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE 1020

Query: 703  KILEPTAFQEPPP----------KPSRPKYRPPPQTNLLAPKLQFQVPEGLCASSPTLTS 752
            + L P AF  PPP            S   + PPP    ++   QF   +G  A+   ++ 
Sbjct: 1021 EYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGN-QFVYRDGGFAAEQGVSV 1079

Query: 753  PMEYPSPVNSLHTPPL 768
            P  Y +P +++   P+
Sbjct: 1080 P--YRAPTSTIPEAPV 1093


>gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog
           4 isoform JM-a/CVT-2 precursor [Homo sapiens]
          Length = 1292

 Score =  213 bits (543), Expect = 6e-55
 Identities = 105/255 (41%), Positives = 163/255 (63%), Gaps = 4/255 (1%)

Query: 429 RILGEGFFGEVYEGVYTNHKGE--KINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHI 486
           ++LG G FG VY+G++   +GE  KI VA+K   +        +FM EA+IM ++DHPH+
Sbjct: 722 KVLGSGAFGTVYKGIWVP-EGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL 780

Query: 487 VKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCV 546
           V+L+G+       ++ +L P+G L  Y+  +K+++    L+ + +QI K M YLE    V
Sbjct: 781 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840

Query: 547 HRDIAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVTRLPIKWMSPESINFRRFTTA 605
           HRD+A RN+LV SP  VK+ DFGL+R +E DE  Y A   ++PIKWM+ E I++R+FT  
Sbjct: 841 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ 900

Query: 606 SDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYD 665
           SDVW + V +WE+++FG +P+  +  +++  +LEKG+RLP+P +C   +Y +M +CW  D
Sbjct: 901 SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID 960

Query: 666 PSDRPRFTELVCSLS 680
              RP+F EL    S
Sbjct: 961 ADSRPKFKELAAEFS 975


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score =  211 bits (537), Expect = 3e-54
 Identities = 107/260 (41%), Positives = 157/260 (60%), Gaps = 7/260 (2%)

Query: 417 QYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAV 476
           ++ + R D+ +   LG G +GEVY GV+  +    + VAVKT K+D      E+F+ EA 
Sbjct: 265 KWEMERTDITMKHKLGGGQYGEVYVGVWKKYS---LTVAVKTLKEDTM--EVEEFLKEAA 319

Query: 477 IMKNLDHPHIVKLIGIIE-EEPTWIIMELYPYGELGHYL-ERNKNSLKVLTLVLYSLQIC 534
           +MK + HP++V+L+G+   E P +I+ E  PYG L  YL E N+  +  + L+  + QI 
Sbjct: 320 VMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQIS 379

Query: 535 KAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSP 594
            AM YLE  N +HRD+A RN LV     VK+ DFGLSR +  + Y   +  + PIKW +P
Sbjct: 380 SAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 439

Query: 595 ESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVL 654
           ES+ +  F+  SDVW F V +WEI ++G  P+  ++   V  +LEKG R+ +P+ CPP +
Sbjct: 440 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 499

Query: 655 YTLMTRCWDYDPSDRPRFTE 674
           Y LM  CW + P+DRP F E
Sbjct: 500 YELMRACWKWSPADRPSFAE 519


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score =  211 bits (537), Expect = 3e-54
 Identities = 107/260 (41%), Positives = 157/260 (60%), Gaps = 7/260 (2%)

Query: 417 QYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAV 476
           ++ + R D+ +   LG G +GEVY GV+  +    + VAVKT K+D      E+F+ EA 
Sbjct: 280 KWEMERTDITMKHKLGGGQYGEVYVGVWKKYS---LTVAVKTLKEDTM--EVEEFLKEAA 334

Query: 477 IMKNLDHPHIVKLIGIIE-EEPTWIIMELYPYGELGHYL-ERNKNSLKVLTLVLYSLQIC 534
           +MK + HP++V+L+G+   E P +I+ E  PYG L  YL E N+  +  + L+  + QI 
Sbjct: 335 VMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQIS 394

Query: 535 KAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSP 594
            AM YLE  N +HRD+A RN LV     VK+ DFGLSR +  + Y   +  + PIKW +P
Sbjct: 395 SAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 454

Query: 595 ESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVL 654
           ES+ +  F+  SDVW F V +WEI ++G  P+  ++   V  +LEKG R+ +P+ CPP +
Sbjct: 455 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 514

Query: 655 YTLMTRCWDYDPSDRPRFTE 674
           Y LM  CW + P+DRP F E
Sbjct: 515 YELMRACWKWSPADRPSFAE 534


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score =  211 bits (537), Expect = 3e-54
 Identities = 107/260 (41%), Positives = 157/260 (60%), Gaps = 7/260 (2%)

Query: 417 QYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAV 476
           ++ + R D+ +   LG G +GEVY GV+  +    + VAVKT K+D      E+F+ EA 
Sbjct: 259 KWEMERTDITMKHKLGGGQYGEVYVGVWKKYS---LTVAVKTLKEDTM--EVEEFLKEAA 313

Query: 477 IMKNLDHPHIVKLIGIIE-EEPTWIIMELYPYGELGHYL-ERNKNSLKVLTLVLYSLQIC 534
           +MK + HP++V+L+G+   E P +I+ E  PYG L  YL E N+  +  + L+  + QI 
Sbjct: 314 VMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQIS 373

Query: 535 KAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSP 594
            AM YLE  N +HRD+A RN LV     VK+ DFGLSR +  + Y   +  + PIKW +P
Sbjct: 374 SAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 433

Query: 595 ESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVL 654
           ES+ +  F+  SDVW F V +WEI ++G  P+  ++   V  +LEKG R+ +P+ CPP +
Sbjct: 434 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 493

Query: 655 YTLMTRCWDYDPSDRPRFTE 674
           Y LM  CW + P+DRP F E
Sbjct: 494 YELMRACWKWSPADRPSFAE 513


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score =  211 bits (537), Expect = 3e-54
 Identities = 107/260 (41%), Positives = 157/260 (60%), Gaps = 7/260 (2%)

Query: 417 QYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAV 476
           ++ + R D+ +   LG G +GEVY GV+  +    + VAVKT K+D      E+F+ EA 
Sbjct: 265 KWEMERTDITMKHKLGGGQYGEVYVGVWKKYS---LTVAVKTLKEDTM--EVEEFLKEAA 319

Query: 477 IMKNLDHPHIVKLIGIIE-EEPTWIIMELYPYGELGHYL-ERNKNSLKVLTLVLYSLQIC 534
           +MK + HP++V+L+G+   E P +I+ E  PYG L  YL E N+  +  + L+  + QI 
Sbjct: 320 VMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQIS 379

Query: 535 KAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSP 594
            AM YLE  N +HRD+A RN LV     VK+ DFGLSR +  + Y   +  + PIKW +P
Sbjct: 380 SAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 439

Query: 595 ESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVL 654
           ES+ +  F+  SDVW F V +WEI ++G  P+  ++   V  +LEKG R+ +P+ CPP +
Sbjct: 440 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 499

Query: 655 YTLMTRCWDYDPSDRPRFTE 674
           Y LM  CW + P+DRP F E
Sbjct: 500 YELMRACWKWSPADRPSFAE 519


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score =  211 bits (537), Expect = 3e-54
 Identities = 107/260 (41%), Positives = 157/260 (60%), Gaps = 7/260 (2%)

Query: 417 QYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAV 476
           ++ + R D+ +   LG G +GEVY GV+  +    + VAVKT K+D      E+F+ EA 
Sbjct: 244 KWEMERTDITMKHKLGGGQYGEVYVGVWKKYS---LTVAVKTLKEDTM--EVEEFLKEAA 298

Query: 477 IMKNLDHPHIVKLIGIIE-EEPTWIIMELYPYGELGHYL-ERNKNSLKVLTLVLYSLQIC 534
           +MK + HP++V+L+G+   E P +I+ E  PYG L  YL E N+  +  + L+  + QI 
Sbjct: 299 VMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQIS 358

Query: 535 KAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSP 594
            AM YLE  N +HRD+A RN LV     VK+ DFGLSR +  + Y   +  + PIKW +P
Sbjct: 359 SAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 418

Query: 595 ESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVL 654
           ES+ +  F+  SDVW F V +WEI ++G  P+  ++   V  +LEKG R+ +P+ CPP +
Sbjct: 419 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 478

Query: 655 YTLMTRCWDYDPSDRPRFTE 674
           Y LM  CW + P+DRP F E
Sbjct: 479 YELMRACWKWSPADRPSFAE 498


>gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]
          Length = 984

 Score =  211 bits (537), Expect = 3e-54
 Identities = 108/260 (41%), Positives = 158/260 (60%), Gaps = 5/260 (1%)

Query: 425 VVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHP 484
           V +  ++G G FGEVY+G        +I VA+KT K   +   +  F+SEA IM   DHP
Sbjct: 619 VKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHP 678

Query: 485 HIVKLIGII-EEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESI 543
           +I++L G++ +  P  II E    G L  +L +N     V+ LV     I   M YL  +
Sbjct: 679 NIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEM 738

Query: 544 NCVHRDIAVRNILVASPECVKLGDFGLSRYIEDED----YYKASVTRLPIKWMSPESINF 599
           N VHRD+A RNILV S    K+ DFGLSRY++D+     Y  +   ++P++W +PE+I +
Sbjct: 739 NYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAY 798

Query: 600 RRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMT 659
           R+FT+ASDVW + + MWE++SFG++P++ + N+DVI  +E+  RLP P  CP  L+ LM 
Sbjct: 799 RKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLML 858

Query: 660 RCWDYDPSDRPRFTELVCSL 679
            CW  D + RPRF E+V +L
Sbjct: 859 DCWQKDRNSRPRFAEIVNTL 878


>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
            sapiens]
          Length = 1367

 Score =  208 bits (530), Expect = 2e-53
 Identities = 121/338 (35%), Positives = 192/338 (56%), Gaps = 31/338 (9%)

Query: 399  SDIYAEIPDETLRRPGGPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEK--INVAV 456
            +D+Y  +PDE         + +ARE + ++R LG+G FG VYEGV      ++    VA+
Sbjct: 984  ADVY--VPDE---------WEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAI 1032

Query: 457  KTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEE-EPTWIIMELYPYGELGHYLE 515
            KT  +  ++  + +F++EA +MK  +  H+V+L+G++ + +PT +IMEL   G+L  YL 
Sbjct: 1033 KTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLR 1092

Query: 516  RNKNSLK---------VLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLG 566
              +  ++         +  ++  + +I   MAYL +   VHRD+A RN +VA    VK+G
Sbjct: 1093 SLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIG 1152

Query: 567  DFGLSRYIEDEDYY-KASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQP 625
            DFG++R I + DYY K     LP++WMSPES+    FTT SDVW F V +WEI +  +QP
Sbjct: 1153 DFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQP 1212

Query: 626  FFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQM 685
            +  L N+ V+  + +G  L KPD CP +L+ LM  CW Y+P  RP F E++ S+ +  +M
Sbjct: 1213 YQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKE--EM 1270

Query: 686  E---KDIAMEQERNARYRTPK--ILEPTAFQEPPPKPS 718
            E   ++++       +   P+   LEP   +  P  PS
Sbjct: 1271 EPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPS 1308


>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
          Length = 526

 Score =  206 bits (525), Expect = 7e-53
 Identities = 109/265 (41%), Positives = 157/265 (59%), Gaps = 7/265 (2%)

Query: 420 IAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMK 479
           I RE + L + LG G FGEV+   Y  H      VAVKT K      + E F++EA +MK
Sbjct: 257 IPRESLKLEKKLGAGQFGEVWMATYNKHT----KVAVKTMKPGSM--SVEAFLAEANVMK 310

Query: 480 NLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLT-LVLYSLQICKAMA 538
            L H  +VKL  ++ +EP +II E    G L  +L+ ++ S + L  L+ +S QI + MA
Sbjct: 311 TLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMA 370

Query: 539 YLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESIN 598
           ++E  N +HRD+   NILV++    K+ DFGL+R IED +Y      + PIKW +PE+IN
Sbjct: 371 FIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 430

Query: 599 FRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLM 658
           F  FT  SDVW F + + EI+++G+ P+  + N +VI  LE+G R+P+P+ CP  LY +M
Sbjct: 431 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIM 490

Query: 659 TRCWDYDPSDRPRFTELVCSLSDVY 683
            RCW   P +RP F  +   L D Y
Sbjct: 491 MRCWKNRPEERPTFEYIQSVLDDFY 515


>gi|54792098 erbB-2 isoform b [Homo sapiens]
          Length = 1225

 Score =  204 bits (520), Expect = 3e-52
 Identities = 101/254 (39%), Positives = 160/254 (62%), Gaps = 2/254 (0%)

Query: 429 RILGEGFFGEVYEGVYT-NHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIV 487
           ++LG G FG VY+G++  + +  KI VA+K  +++ +    ++ + EA +M  +  P++ 
Sbjct: 694 KVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVS 753

Query: 488 KLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVH 547
           +L+GI       ++ +L PYG L  ++  N+  L    L+ + +QI K M+YLE +  VH
Sbjct: 754 RLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVH 813

Query: 548 RDIAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVTRLPIKWMSPESINFRRFTTAS 606
           RD+A RN+LV SP  VK+ DFGL+R ++ DE  Y A   ++PIKWM+ ESI  RRFT  S
Sbjct: 814 RDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQS 873

Query: 607 DVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDP 666
           DVW + V +WE+++FG +P+  +  +++  +LEKG+RLP+P +C   +Y +M +CW  D 
Sbjct: 874 DVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDS 933

Query: 667 SDRPRFTELVCSLS 680
             RPRF ELV   S
Sbjct: 934 ECRPRFRELVSEFS 947


>gi|54792096 erbB-2 isoform a [Homo sapiens]
          Length = 1255

 Score =  204 bits (520), Expect = 3e-52
 Identities = 101/254 (39%), Positives = 160/254 (62%), Gaps = 2/254 (0%)

Query: 429 RILGEGFFGEVYEGVYT-NHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIV 487
           ++LG G FG VY+G++  + +  KI VA+K  +++ +    ++ + EA +M  +  P++ 
Sbjct: 724 KVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVS 783

Query: 488 KLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVH 547
           +L+GI       ++ +L PYG L  ++  N+  L    L+ + +QI K M+YLE +  VH
Sbjct: 784 RLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVH 843

Query: 548 RDIAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVTRLPIKWMSPESINFRRFTTAS 606
           RD+A RN+LV SP  VK+ DFGL+R ++ DE  Y A   ++PIKWM+ ESI  RRFT  S
Sbjct: 844 RDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQS 903

Query: 607 DVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDP 666
           DVW + V +WE+++FG +P+  +  +++  +LEKG+RLP+P +C   +Y +M +CW  D 
Sbjct: 904 DVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDS 963

Query: 667 SDRPRFTELVCSLS 680
             RPRF ELV   S
Sbjct: 964 ECRPRFRELVSEFS 977


>gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo
           sapiens]
          Length = 986

 Score =  204 bits (520), Expect = 3e-52
 Identities = 106/260 (40%), Positives = 156/260 (60%), Gaps = 5/260 (1%)

Query: 425 VVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHP 484
           V + +++G G FGEV  G        +I VA+KT K   T   +  F+SEA IM   DHP
Sbjct: 621 VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHP 680

Query: 485 HIVKLIGIIEEE-PTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESI 543
           +++ L G++ +  P  II E    G L  +L +N     V+ LV     I   M YL  +
Sbjct: 681 NVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADM 740

Query: 544 NCVHRDIAVRNILVASPECVKLGDFGLSRYIEDED----YYKASVTRLPIKWMSPESINF 599
           N VHRD+A RNILV S    K+ DFGLSR++ED+     Y  A   ++PI+W +PE+I +
Sbjct: 741 NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQY 800

Query: 600 RRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMT 659
           R+FT+ASDVW + + MWE++S+G++P++ + N+DVI  +E+  RLP P  CP  L+ LM 
Sbjct: 801 RKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLML 860

Query: 660 RCWDYDPSDRPRFTELVCSL 679
            CW  D + RP+F ++V +L
Sbjct: 861 DCWQKDRNHRPKFGQIVNTL 880


>gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo
           sapiens]
          Length = 987

 Score =  204 bits (520), Expect = 3e-52
 Identities = 106/260 (40%), Positives = 156/260 (60%), Gaps = 5/260 (1%)

Query: 425 VVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHP 484
           V + +++G G FGEV  G        +I VA+KT K   T   +  F+SEA IM   DHP
Sbjct: 622 VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHP 681

Query: 485 HIVKLIGIIEEE-PTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESI 543
           +++ L G++ +  P  II E    G L  +L +N     V+ LV     I   M YL  +
Sbjct: 682 NVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADM 741

Query: 544 NCVHRDIAVRNILVASPECVKLGDFGLSRYIEDED----YYKASVTRLPIKWMSPESINF 599
           N VHRD+A RNILV S    K+ DFGLSR++ED+     Y  A   ++PI+W +PE+I +
Sbjct: 742 NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQY 801

Query: 600 RRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMT 659
           R+FT+ASDVW + + MWE++S+G++P++ + N+DVI  +E+  RLP P  CP  L+ LM 
Sbjct: 802 RKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLML 861

Query: 660 RCWDYDPSDRPRFTELVCSL 679
            CW  D + RP+F ++V +L
Sbjct: 862 DCWQKDRNHRPKFGQIVNTL 881


>gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo
           sapiens]
          Length = 1015

 Score =  204 bits (519), Expect = 3e-52
 Identities = 104/255 (40%), Positives = 153/255 (60%), Gaps = 3/255 (1%)

Query: 425 VVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHP 484
           + + R++G G FGEV  G        ++ VA+KT K   T   +  F+ EA IM   DHP
Sbjct: 653 ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHP 712

Query: 485 HIVKLIGII-EEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESI 543
           +I+ L G++ + +P  I+ E    G L  +L++N     V+ LV     I   M YL  +
Sbjct: 713 NIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDM 772

Query: 544 NCVHRDIAVRNILVASPECVKLGDFGLSRYIED--EDYYKASVTRLPIKWMSPESINFRR 601
             VHRD+A RNIL+ S    K+ DFGLSR +ED  E  Y     ++PI+W +PE+I FR+
Sbjct: 773 GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRK 832

Query: 602 FTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRC 661
           FT+ASDVW + + MWE++S+G++P++ + N+DVI  +E+G RLP P  CP  LY LM  C
Sbjct: 833 FTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDC 892

Query: 662 WDYDPSDRPRFTELV 676
           W  + + RP+F E+V
Sbjct: 893 WQKERNSRPKFDEIV 907


>gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo
           sapiens]
          Length = 1037

 Score =  204 bits (519), Expect = 3e-52
 Identities = 104/255 (40%), Positives = 153/255 (60%), Gaps = 3/255 (1%)

Query: 425 VVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHP 484
           + + R++G G FGEV  G        ++ VA+KT K   T   +  F+ EA IM   DHP
Sbjct: 675 ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHP 734

Query: 485 HIVKLIGII-EEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESI 543
           +I+ L G++ + +P  I+ E    G L  +L++N     V+ LV     I   M YL  +
Sbjct: 735 NIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDM 794

Query: 544 NCVHRDIAVRNILVASPECVKLGDFGLSRYIED--EDYYKASVTRLPIKWMSPESINFRR 601
             VHRD+A RNIL+ S    K+ DFGLSR +ED  E  Y     ++PI+W +PE+I FR+
Sbjct: 795 GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRK 854

Query: 602 FTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRC 661
           FT+ASDVW + + MWE++S+G++P++ + N+DVI  +E+G RLP P  CP  LY LM  C
Sbjct: 855 FTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDC 914

Query: 662 WDYDPSDRPRFTELV 676
           W  + + RP+F E+V
Sbjct: 915 WQKERNSRPKFDEIV 929


>gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo
           sapiens]
          Length = 983

 Score =  204 bits (519), Expect = 3e-52
 Identities = 102/259 (39%), Positives = 159/259 (61%), Gaps = 3/259 (1%)

Query: 424 DVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDH 483
           ++ +++++G G FGEV  G       ++I+VA+KT K   T   +  F+ EA IM   DH
Sbjct: 620 NISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDH 679

Query: 484 PHIVKLIGII-EEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLES 542
           P+I++L G++ + +P  I+ E    G L  +L ++     V+ LV     I   M YL  
Sbjct: 680 PNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSD 739

Query: 543 INCVHRDIAVRNILVASPECVKLGDFGLSRYIED--EDYYKASVTRLPIKWMSPESINFR 600
           +  VHRD+A RNIL+ S    K+ DFGLSR +ED  E  Y     ++PI+W SPE+I +R
Sbjct: 740 MGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYR 799

Query: 601 RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTR 660
           +FT+ASDVW + + +WE++S+G++P++ + N+DVI  +++G RLP P  CP  LY LM  
Sbjct: 800 KFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLD 859

Query: 661 CWDYDPSDRPRFTELVCSL 679
           CW  D ++RP+F ++V  L
Sbjct: 860 CWQKDRNNRPKFEQIVSIL 878


>gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]
          Length = 694

 Score =  204 bits (518), Expect = 4e-52
 Identities = 115/321 (35%), Positives = 182/321 (56%), Gaps = 22/321 (6%)

Query: 367 RKDGEKRNSLPQIPML--NLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGIARED 424
           R +GE     P IP+L  +L + +  L++   +   ++  +P +        ++ +  ED
Sbjct: 386 RLEGE---GFPSIPLLIDHLLSTQQPLTKKSGVV--LHRAVPKD--------KWVLNHED 432

Query: 425 VVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHP 484
           +VL   +G G FGEV+ G     + +   VAVK+C++    D K KF+ EA I+K   HP
Sbjct: 433 LVLGEQIGRGNFGEVFSG---RLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHP 489

Query: 485 HIVKLIGII-EEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESI 543
           +IV+LIG+  +++P +I+MEL   G+   +L      L+V TL+         M YLES 
Sbjct: 490 NIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESK 549

Query: 544 NCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKAS--VTRLPIKWMSPESINFRR 601
            C+HRD+A RN LV     +K+ DFG+SR  E +  Y AS  + ++P+KW +PE++N+ R
Sbjct: 550 CCIHRDLAARNCLVTEKNVLKISDFGMSRE-EADGVYAASGGLRQVPVKWTAPEALNYGR 608

Query: 602 FTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRC 661
           +++ SDVW F + +WE  S G  P+  L N+     +EKG RLP P+LCP  ++ LM +C
Sbjct: 609 YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQC 668

Query: 662 WDYDPSDRPRFTELVCSLSDV 682
           W Y+P  RP F+ +   L  +
Sbjct: 669 WAYEPGQRPSFSTIYQELQSI 689


>gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]
          Length = 752

 Score =  204 bits (518), Expect = 4e-52
 Identities = 115/321 (35%), Positives = 182/321 (56%), Gaps = 22/321 (6%)

Query: 367 RKDGEKRNSLPQIPML--NLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGIARED 424
           R +GE     P IP+L  +L + +  L++   +   ++  +P +        ++ +  ED
Sbjct: 444 RLEGE---GFPSIPLLIDHLLSTQQPLTKKSGVV--LHRAVPKD--------KWVLNHED 490

Query: 425 VVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHP 484
           +VL   +G G FGEV+ G     + +   VAVK+C++    D K KF+ EA I+K   HP
Sbjct: 491 LVLGEQIGRGNFGEVFSG---RLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHP 547

Query: 485 HIVKLIGII-EEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESI 543
           +IV+LIG+  +++P +I+MEL   G+   +L      L+V TL+         M YLES 
Sbjct: 548 NIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESK 607

Query: 544 NCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKAS--VTRLPIKWMSPESINFRR 601
            C+HRD+A RN LV     +K+ DFG+SR  E +  Y AS  + ++P+KW +PE++N+ R
Sbjct: 608 CCIHRDLAARNCLVTEKNVLKISDFGMSRE-EADGVYAASGGLRQVPVKWTAPEALNYGR 666

Query: 602 FTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRC 661
           +++ SDVW F + +WE  S G  P+  L N+     +EKG RLP P+LCP  ++ LM +C
Sbjct: 667 YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQC 726

Query: 662 WDYDPSDRPRFTELVCSLSDV 682
           W Y+P  RP F+ +   L  +
Sbjct: 727 WAYEPGQRPSFSTIYQELQSI 747


>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
          Length = 764

 Score =  204 bits (518), Expect = 4e-52
 Identities = 115/321 (35%), Positives = 182/321 (56%), Gaps = 22/321 (6%)

Query: 367 RKDGEKRNSLPQIPML--NLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGIARED 424
           R +GE     P IP+L  +L + +  L++   +   ++  +P +        ++ +  ED
Sbjct: 456 RLEGE---GFPSIPLLIDHLLSTQQPLTKKSGVV--LHRAVPKD--------KWVLNHED 502

Query: 425 VVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHP 484
           +VL   +G G FGEV+ G     + +   VAVK+C++    D K KF+ EA I+K   HP
Sbjct: 503 LVLGEQIGRGNFGEVFSG---RLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHP 559

Query: 485 HIVKLIGII-EEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESI 543
           +IV+LIG+  +++P +I+MEL   G+   +L      L+V TL+         M YLES 
Sbjct: 560 NIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESK 619

Query: 544 NCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKAS--VTRLPIKWMSPESINFRR 601
            C+HRD+A RN LV     +K+ DFG+SR  E +  Y AS  + ++P+KW +PE++N+ R
Sbjct: 620 CCIHRDLAARNCLVTEKNVLKISDFGMSRE-EADGVYAASGGLRQVPVKWTAPEALNYGR 678

Query: 602 FTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRC 661
           +++ SDVW F + +WE  S G  P+  L N+     +EKG RLP P+LCP  ++ LM +C
Sbjct: 679 YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQC 738

Query: 662 WDYDPSDRPRFTELVCSLSDV 682
           W Y+P  RP F+ +   L  +
Sbjct: 739 WAYEPGQRPSFSTIYQELQSI 759


>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
          Length = 822

 Score =  204 bits (518), Expect = 4e-52
 Identities = 115/321 (35%), Positives = 182/321 (56%), Gaps = 22/321 (6%)

Query: 367 RKDGEKRNSLPQIPML--NLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGIARED 424
           R +GE     P IP+L  +L + +  L++   +   ++  +P +        ++ +  ED
Sbjct: 514 RLEGE---GFPSIPLLIDHLLSTQQPLTKKSGVV--LHRAVPKD--------KWVLNHED 560

Query: 425 VVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHP 484
           +VL   +G G FGEV+ G     + +   VAVK+C++    D K KF+ EA I+K   HP
Sbjct: 561 LVLGEQIGRGNFGEVFSG---RLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHP 617

Query: 485 HIVKLIGII-EEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESI 543
           +IV+LIG+  +++P +I+MEL   G+   +L      L+V TL+         M YLES 
Sbjct: 618 NIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESK 677

Query: 544 NCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKAS--VTRLPIKWMSPESINFRR 601
            C+HRD+A RN LV     +K+ DFG+SR  E +  Y AS  + ++P+KW +PE++N+ R
Sbjct: 678 CCIHRDLAARNCLVTEKNVLKISDFGMSRE-EADGVYAASGGLRQVPVKWTAPEALNYGR 736

Query: 602 FTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRC 661
           +++ SDVW F + +WE  S G  P+  L N+     +EKG RLP P+LCP  ++ LM +C
Sbjct: 737 YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQC 796

Query: 662 WDYDPSDRPRFTELVCSLSDV 682
           W Y+P  RP F+ +   L  +
Sbjct: 797 WAYEPGQRPSFSTIYQELQSI 817


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,802,862
Number of Sequences: 37866
Number of extensions: 2067261
Number of successful extensions: 10808
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 545
Number of HSP's successfully gapped in prelim test: 375
Number of HSP's that attempted gapping in prelim test: 8372
Number of HSP's gapped (non-prelim): 1663
length of query: 1009
length of database: 18,247,518
effective HSP length: 112
effective length of query: 897
effective length of database: 14,006,526
effective search space: 12563853822
effective search space used: 12563853822
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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