Guide to the Human Genome
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Search of human proteins with 239751523

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239751523 PREDICTED: ankyrin repeat domain 20 family, member
A5 [Homo sapiens]
         (823 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239757009 PREDICTED: ankyrin repeat domain 20 family, member ...  1617   0.0  
gi|239751523 PREDICTED: ankyrin repeat domain 20 family, member ...  1617   0.0  
gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo sap...  1423   0.0  
gi|149363679 ankyrin repeat domain 20 family, member A4 [Homo sa...  1420   0.0  
gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo sap...  1417   0.0  
gi|156104901 ankyrin repeat domain 20 family, member A1 [Homo sa...  1415   0.0  
gi|239746016 PREDICTED: ankyrin repeat domain 62 isoform 1 [Homo...   459   e-129
gi|239756999 PREDICTED: ankyrin repeat domain 62 [Homo sapiens]       458   e-128
gi|239751514 PREDICTED: ankyrin repeat domain 62 isoform 4 [Homo...   458   e-128
gi|239741279 PREDICTED: similar to FLJ00310 protein [Homo sapiens]    370   e-102
gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]      358   1e-98
gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]      358   1e-98
gi|239743705 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]      357   3e-98
gi|239755047 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]      353   4e-97
gi|239749578 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]      353   4e-97
gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]      353   4e-97
gi|154354990 ankyrin repeat domain 26 [Homo sapiens]                  325   1e-88
gi|115495445 ankyrin repeat domain 30A [Homo sapiens]                 295   9e-80
gi|222537750 ankyrin repeat domain 30B [Homo sapiens]                 293   3e-79
gi|149363642 coiled-coil domain containing 144A [Homo sapiens]        279   7e-75
gi|153791352 prostate, ovary, testis expressed protein on chromo...   257   3e-68
gi|134133226 protein expressed in prostate, ovary, testis, and p...   256   5e-68
gi|88953571 PREDICTED: similar to protein expressed in prostate,...   253   5e-67
gi|113413200 PREDICTED: similar to protein expressed in prostate...   253   7e-67
gi|239741673 PREDICTED: protein immuno-reactive with anti-PTH po...   252   9e-67
gi|239747793 PREDICTED: protein immuno-reactive with anti-PTH po...   251   2e-66
gi|239741684 PREDICTED: ankyrin repeat domain 36 [Homo sapiens]       249   6e-66
gi|124517695 ankyrin repeat domain 36B [Homo sapiens]                 249   6e-66
gi|52856430 protein expressed in prostate, ovary, testis, and pl...   247   3e-65
gi|169163827 PREDICTED: similar to UPF0634 protein KIAA1641 [Hom...   245   1e-64

>gi|239757009 PREDICTED: ankyrin repeat domain 20 family, member A5
           [Homo sapiens]
          Length = 823

 Score = 1617 bits (4186), Expect = 0.0
 Identities = 823/823 (100%), Positives = 823/823 (100%)

Query: 1   MKLFGFRSRRGQTVLGSIDHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDL 60
           MKLFGFRSRRGQTVLGSIDHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDL
Sbjct: 1   MKLFGFRSRRGQTVLGSIDHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDL 60

Query: 61  DALDKQHRTALHLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILL 120
           DALDKQHRTALHLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILL
Sbjct: 61  DALDKQHRTALHLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILL 120

Query: 121 EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEK 180
           EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEK
Sbjct: 121 EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEK 180

Query: 181 MVEFLLKNKASTHAVDRLRXTALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAI 240
           MVEFLLKNKASTHAVDRLR TALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAI
Sbjct: 181 MVEFLLKNKASTHAVDRLRXTALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAI 240

Query: 241 SCRLTKIQQQILEHKKMILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQC 300
           SCRLTKIQQQILEHKKMILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQC
Sbjct: 241 SCRLTKIQQQILEHKKMILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQC 300

Query: 301 VPEKVSEPLRGPSHGKGNRIVNGKGEGPPAKHPSLKPSTEMEDPAVKGAVQXKNVQTLRA 360
           VPEKVSEPLRGPSHGKGNRIVNGKGEGPPAKHPSLKPSTEMEDPAVKGAVQ KNVQTLRA
Sbjct: 301 VPEKVSEPLRGPSHGKGNRIVNGKGEGPPAKHPSLKPSTEMEDPAVKGAVQXKNVQTLRA 360

Query: 361 EQALPVASEEEQQRRERSEKKQPQVIEGNNTYKSEKIQLSENICHSTFSAAADRLTQQRK 420
           EQALPVASEEEQQRRERSEKKQPQVIEGNNTYKSEKIQLSENICHSTFSAAADRLTQQRK
Sbjct: 361 EQALPVASEEEQQRRERSEKKQPQVIEGNNTYKSEKIQLSENICHSTFSAAADRLTQQRK 420

Query: 421 IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLHKKNREELERKEKQYKKEVEAKQLE 480
           IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLHKKNREELERKEKQYKKEVEAKQLE
Sbjct: 421 IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLHKKNREELERKEKQYKKEVEAKQLE 480

Query: 481 PTVQSLEMKPKTARNTPNQDFHNHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKEN 540
           PTVQSLEMKPKTARNTPNQDFHNHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKEN
Sbjct: 481 PTVQSLEMKPKTARNTPNQDFHNHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKEN 540

Query: 541 KYLKDIKIAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAENTRLNSELLKEKESKK 600
           KYLKDIKIAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAENTRLNSELLKEKESKK
Sbjct: 541 KYLKDIKIAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAENTRLNSELLKEKESKK 600

Query: 601 KLEAEIESYQSRLAAAISKHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFL 660
           KLEAEIESYQSRLAAAISKHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKN FL
Sbjct: 601 KLEAEIESYQSRLAAAISKHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFL 660

Query: 661 TEQLSKMQIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKV 720
           TEQLSKMQIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKV
Sbjct: 661 TEQLSKMQIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKV 720

Query: 721 SKSTGKWNCVEERICQLQRENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEE 780
           SKSTGKWNCVEERICQLQRENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEE
Sbjct: 721 SKSTGKWNCVEERICQLQRENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEE 780

Query: 781 KNKKLMNEYDHLKESLFQYERQKAETVVSIKEDKYFQTSRKKV 823
           KNKKLMNEYDHLKESLFQYERQKAETVVSIKEDKYFQTSRKKV
Sbjct: 781 KNKKLMNEYDHLKESLFQYERQKAETVVSIKEDKYFQTSRKKV 823


>gi|239751523 PREDICTED: ankyrin repeat domain 20 family, member A5
           [Homo sapiens]
          Length = 823

 Score = 1617 bits (4186), Expect = 0.0
 Identities = 823/823 (100%), Positives = 823/823 (100%)

Query: 1   MKLFGFRSRRGQTVLGSIDHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDL 60
           MKLFGFRSRRGQTVLGSIDHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDL
Sbjct: 1   MKLFGFRSRRGQTVLGSIDHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDL 60

Query: 61  DALDKQHRTALHLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILL 120
           DALDKQHRTALHLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILL
Sbjct: 61  DALDKQHRTALHLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILL 120

Query: 121 EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEK 180
           EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEK
Sbjct: 121 EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEK 180

Query: 181 MVEFLLKNKASTHAVDRLRXTALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAI 240
           MVEFLLKNKASTHAVDRLR TALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAI
Sbjct: 181 MVEFLLKNKASTHAVDRLRXTALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAI 240

Query: 241 SCRLTKIQQQILEHKKMILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQC 300
           SCRLTKIQQQILEHKKMILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQC
Sbjct: 241 SCRLTKIQQQILEHKKMILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQC 300

Query: 301 VPEKVSEPLRGPSHGKGNRIVNGKGEGPPAKHPSLKPSTEMEDPAVKGAVQXKNVQTLRA 360
           VPEKVSEPLRGPSHGKGNRIVNGKGEGPPAKHPSLKPSTEMEDPAVKGAVQ KNVQTLRA
Sbjct: 301 VPEKVSEPLRGPSHGKGNRIVNGKGEGPPAKHPSLKPSTEMEDPAVKGAVQXKNVQTLRA 360

Query: 361 EQALPVASEEEQQRRERSEKKQPQVIEGNNTYKSEKIQLSENICHSTFSAAADRLTQQRK 420
           EQALPVASEEEQQRRERSEKKQPQVIEGNNTYKSEKIQLSENICHSTFSAAADRLTQQRK
Sbjct: 361 EQALPVASEEEQQRRERSEKKQPQVIEGNNTYKSEKIQLSENICHSTFSAAADRLTQQRK 420

Query: 421 IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLHKKNREELERKEKQYKKEVEAKQLE 480
           IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLHKKNREELERKEKQYKKEVEAKQLE
Sbjct: 421 IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLHKKNREELERKEKQYKKEVEAKQLE 480

Query: 481 PTVQSLEMKPKTARNTPNQDFHNHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKEN 540
           PTVQSLEMKPKTARNTPNQDFHNHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKEN
Sbjct: 481 PTVQSLEMKPKTARNTPNQDFHNHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKEN 540

Query: 541 KYLKDIKIAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAENTRLNSELLKEKESKK 600
           KYLKDIKIAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAENTRLNSELLKEKESKK
Sbjct: 541 KYLKDIKIAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAENTRLNSELLKEKESKK 600

Query: 601 KLEAEIESYQSRLAAAISKHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFL 660
           KLEAEIESYQSRLAAAISKHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKN FL
Sbjct: 601 KLEAEIESYQSRLAAAISKHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFL 660

Query: 661 TEQLSKMQIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKV 720
           TEQLSKMQIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKV
Sbjct: 661 TEQLSKMQIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKV 720

Query: 721 SKSTGKWNCVEERICQLQRENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEE 780
           SKSTGKWNCVEERICQLQRENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEE
Sbjct: 721 SKSTGKWNCVEERICQLQRENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEE 780

Query: 781 KNKKLMNEYDHLKESLFQYERQKAETVVSIKEDKYFQTSRKKV 823
           KNKKLMNEYDHLKESLFQYERQKAETVVSIKEDKYFQTSRKKV
Sbjct: 781 KNKKLMNEYDHLKESLFQYERQKAETVVSIKEDKYFQTSRKKV 823


>gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo
           sapiens]
          Length = 823

 Score = 1423 bits (3683), Expect = 0.0
 Identities = 728/823 (88%), Positives = 770/823 (93%)

Query: 1   MKLFGFRSRRGQTVLGSIDHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDL 60
           MKLFGF SRRGQT  GSIDH+YTGSGYRIR SELQKIH+AAVKGDAAE+ERCLARRSGDL
Sbjct: 1   MKLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDL 60

Query: 61  DALDKQHRTALHLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILL 120
           DALDKQHRTALHLACASGHV+VVTLLVNRKCQID+ DKENRTPLIQAVHCQEEACAVILL
Sbjct: 61  DALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILL 120

Query: 121 EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEK 180
           EHGANPNLKDIYGNTALHYAVYSESTSLAEKLL HG +IEALDKD+NTPLLFAIICKKEK
Sbjct: 121 EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEK 180

Query: 181 MVEFLLKNKASTHAVDRLRXTALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAI 240
           MVEFLLK KAS+HAVDRLR +ALMLAV+YDS GIVNILLKQ+I+VF QDMCGRDAEDYAI
Sbjct: 181 MVEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAI 240

Query: 241 SCRLTKIQQQILEHKKMILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQC 300
           S  LTKIQQQILEHKK ILK +K DVGSSDESAVSIFHEL VDSL A DD+ L+VA KQC
Sbjct: 241 SHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQC 300

Query: 301 VPEKVSEPLRGPSHGKGNRIVNGKGEGPPAKHPSLKPSTEMEDPAVKGAVQXKNVQTLRA 360
           VPEKVSEPL G SH KGNRIVNG+GEGPPAKHPSLKPSTE+EDPAVKGAVQ KNVQTLRA
Sbjct: 301 VPEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRA 360

Query: 361 EQALPVASEEEQQRRERSEKKQPQVIEGNNTYKSEKIQLSENICHSTFSAAADRLTQQRK 420
           EQALPVASEEEQ+R ERSEKKQPQV EGNNT KSEKIQLSENIC ST SAAA RLTQQRK
Sbjct: 361 EQALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK 420

Query: 421 IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLHKKNREELERKEKQYKKEVEAKQLE 480
           IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNML+KKNREELERKEKQYKKEVEAKQLE
Sbjct: 421 IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLE 480

Query: 481 PTVQSLEMKPKTARNTPNQDFHNHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKEN 540
           PTVQSLEMK KTARNTPN+DFHNHEE+K LMDENCILK DIAILRQEICTMKNDNLEKEN
Sbjct: 481 PTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKEN 540

Query: 541 KYLKDIKIAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAENTRLNSELLKEKESKK 600
           KYLKDIKI KETNAALEK IKLNEEMIT+TAF YQQELNDLKAENTRLN+ELLKEKESKK
Sbjct: 541 KYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKK 600

Query: 601 KLEAEIESYQSRLAAAISKHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFL 660
           +LEA+IESYQSRLAAAISKHSE+VKTERNLKLALERT+D+S QV+MSS IS+++D+N FL
Sbjct: 601 RLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFL 660

Query: 661 TEQLSKMQIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKV 720
           TEQLS+ QIKFN LKDKFRKTRD+LRKKSLALETVQNDLSQTQQQ +EMKEMYQ+AEAKV
Sbjct: 661 TEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKV 720

Query: 721 SKSTGKWNCVEERICQLQRENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEE 780
           + STGKWNCVEERIC LQREN WL QQL DVHQKEDHKEIV NIQRGFIES KKDL+LEE
Sbjct: 721 NNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEE 780

Query: 781 KNKKLMNEYDHLKESLFQYERQKAETVVSIKEDKYFQTSRKKV 823
           K+KKLMNE DHLKESLFQYER+K E VVSIKEDKYFQTSRKK+
Sbjct: 781 KSKKLMNECDHLKESLFQYEREKTEGVVSIKEDKYFQTSRKKI 823


>gi|149363679 ankyrin repeat domain 20 family, member A4 [Homo
           sapiens]
          Length = 823

 Score = 1420 bits (3676), Expect = 0.0
 Identities = 727/823 (88%), Positives = 768/823 (93%)

Query: 1   MKLFGFRSRRGQTVLGSIDHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDL 60
           MKLFGF SRRGQT  GSIDH+YTGSGYRIR SELQKIH+AAVKGDAAE+ERCLARRSG+L
Sbjct: 1   MKLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGEL 60

Query: 61  DALDKQHRTALHLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILL 120
           DALDKQHRTALHLACASGHV+VVTLLVNRKCQID+ DKENRTPLIQAVHCQEEACAVILL
Sbjct: 61  DALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILL 120

Query: 121 EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEK 180
           EHGANPNLKDIYGNTALHYAVYSESTSLAEKLL HG +IEALDKD+NTPLLFAIICKKEK
Sbjct: 121 EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEK 180

Query: 181 MVEFLLKNKASTHAVDRLRXTALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAI 240
           MVEFLLK KAS+HAVDRLR +ALMLAV+YDS GIVNILLKQ+I+VF QDMCGRDAEDYAI
Sbjct: 181 MVEFLLKKKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAI 240

Query: 241 SCRLTKIQQQILEHKKMILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQC 300
           S  LTKIQQQILEHKK ILK +K DVGSSDESAVSIFHEL VDSL A DD+ L+VA KQC
Sbjct: 241 SHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQC 300

Query: 301 VPEKVSEPLRGPSHGKGNRIVNGKGEGPPAKHPSLKPSTEMEDPAVKGAVQXKNVQTLRA 360
           VPEKVSEPL G SH KGNRIVNG+GEGPPAKHPSLKPSTE+EDPAVKGAVQ KNVQTLRA
Sbjct: 301 VPEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRA 360

Query: 361 EQALPVASEEEQQRRERSEKKQPQVIEGNNTYKSEKIQLSENICHSTFSAAADRLTQQRK 420
           EQALPVASEEEQQR ERSEKKQPQV EGNNT KSEKIQLSENIC ST SAAA RLTQQRK
Sbjct: 361 EQALPVASEEEQQRHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK 420

Query: 421 IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLHKKNREELERKEKQYKKEVEAKQLE 480
           IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNML+KKNREELERKEKQYKKEVEAKQLE
Sbjct: 421 IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLE 480

Query: 481 PTVQSLEMKPKTARNTPNQDFHNHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKEN 540
           PTVQSLEMK KTARNTPN DFHNHEE+K LMDENCILK DIAILRQEICTMKNDNLEKEN
Sbjct: 481 PTVQSLEMKSKTARNTPNWDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKEN 540

Query: 541 KYLKDIKIAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAENTRLNSELLKEKESKK 600
           KYLKDIKI KETNAALEK IKLNEEMIT+TAF YQQELNDLKAENTRLN+ELLKEKESKK
Sbjct: 541 KYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKK 600

Query: 601 KLEAEIESYQSRLAAAISKHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFL 660
           +LEA+IESYQSRLAAAISKHSE+VKTERNLKLALERTQD+S QV+MSS IS+++D+N FL
Sbjct: 601 RLEADIESYQSRLAAAISKHSESVKTERNLKLALERTQDVSVQVEMSSAISKVKDENEFL 660

Query: 661 TEQLSKMQIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKV 720
           TEQLS+ QIKFN LKDKFRKTRD+LRKKSLALETVQN+LSQTQQQ +EMKEMYQ+AEAKV
Sbjct: 661 TEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNNLSQTQQQTQEMKEMYQNAEAKV 720

Query: 721 SKSTGKWNCVEERICQLQRENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEE 780
           + STGKWNCVEERIC LQREN WL QQL DVHQKEDHKEIV NIQRGFIES KKD +LEE
Sbjct: 721 NNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDFVLEE 780

Query: 781 KNKKLMNEYDHLKESLFQYERQKAETVVSIKEDKYFQTSRKKV 823
           K+KKLMNE DHLKESLFQYER+K E VVSIKEDKYFQTSRKK+
Sbjct: 781 KSKKLMNECDHLKESLFQYEREKTEVVVSIKEDKYFQTSRKKI 823


>gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo
           sapiens]
          Length = 823

 Score = 1417 bits (3668), Expect = 0.0
 Identities = 726/823 (88%), Positives = 768/823 (93%)

Query: 1   MKLFGFRSRRGQTVLGSIDHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDL 60
           MKLFGF SRRGQT  GSIDH+YTGSGYRIR SELQKIH+AAVKGDAAE+ERCLARRSGDL
Sbjct: 1   MKLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDL 60

Query: 61  DALDKQHRTALHLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILL 120
           DALDKQHRTALHLACASGHV+VVTLLVNRKCQID+ DKENRTPLIQAVHCQEEACAVILL
Sbjct: 61  DALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILL 120

Query: 121 EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEK 180
           EHGANPNLKDIYGNTALHYAVYSESTSLAEKLL HG +IEALDKD+NTPLLFAIICKKEK
Sbjct: 121 EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEK 180

Query: 181 MVEFLLKNKASTHAVDRLRXTALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAI 240
           MVEFLLK KAS+HAVDRLR +ALMLAV+YDS GIVNILLKQ+I+VF QDMCGRDAEDYAI
Sbjct: 181 MVEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAI 240

Query: 241 SCRLTKIQQQILEHKKMILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQC 300
           S  LTKIQQQILEHKK ILK +K DVGSSDESAVSIFHEL VDSL A DD+ L+VA KQC
Sbjct: 241 SHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQC 300

Query: 301 VPEKVSEPLRGPSHGKGNRIVNGKGEGPPAKHPSLKPSTEMEDPAVKGAVQXKNVQTLRA 360
           VPEKVSEPL G SH KGNRIVNG+GEGPPAKHPSLKPSTE+EDPAVKGAVQ KNVQTLRA
Sbjct: 301 VPEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRA 360

Query: 361 EQALPVASEEEQQRRERSEKKQPQVIEGNNTYKSEKIQLSENICHSTFSAAADRLTQQRK 420
           EQALPVASEEEQ+R ERSEKKQPQV EGNNT KSEKIQLSENIC ST SAAA RLTQQRK
Sbjct: 361 EQALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK 420

Query: 421 IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLHKKNREELERKEKQYKKEVEAKQLE 480
           IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNML+KKNREELERKEKQYKKEVEAKQLE
Sbjct: 421 IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLE 480

Query: 481 PTVQSLEMKPKTARNTPNQDFHNHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKEN 540
           PTVQSLEMK KTARNTPN+DFHNHEE+K LMDENCILK DIAILRQEICTMKNDNLEKEN
Sbjct: 481 PTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKEN 540

Query: 541 KYLKDIKIAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAENTRLNSELLKEKESKK 600
           KYLKDIKI KETNAALEK IKLNEEMIT+TAF YQQELN LKAENTRLN+ELLKEKESKK
Sbjct: 541 KYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNYLKAENTRLNAELLKEKESKK 600

Query: 601 KLEAEIESYQSRLAAAISKHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFL 660
           +LEA+IESYQSRLAAAISKHSE+VKTERNLKLALERT+D+S QV+MSS IS+++D+N FL
Sbjct: 601 RLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFL 660

Query: 661 TEQLSKMQIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKV 720
           TEQLS+ QIKFN LKDKFRKTRD+LRKKSLALETVQNDLSQTQQQ +EMKEMYQ+AEAKV
Sbjct: 661 TEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKV 720

Query: 721 SKSTGKWNCVEERICQLQRENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEE 780
           + STGKWNCVEERIC LQREN WL QQL DVHQKEDHKEIV NIQRGFIES KKDL+LEE
Sbjct: 721 NNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEE 780

Query: 781 KNKKLMNEYDHLKESLFQYERQKAETVVSIKEDKYFQTSRKKV 823
           K+KKLMNE DHLKESLFQYER+K E VVSIKEDKYFQTSRK +
Sbjct: 781 KSKKLMNECDHLKESLFQYEREKTEGVVSIKEDKYFQTSRKTI 823


>gi|156104901 ankyrin repeat domain 20 family, member A1 [Homo
           sapiens]
          Length = 823

 Score = 1415 bits (3662), Expect = 0.0
 Identities = 725/823 (88%), Positives = 766/823 (93%)

Query: 1   MKLFGFRSRRGQTVLGSIDHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDL 60
           MKLFGF SRRGQT  GSIDH+YTGSGYRIR SELQKIH+AAVKGDAAE+ERCLARRSGDL
Sbjct: 1   MKLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDL 60

Query: 61  DALDKQHRTALHLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILL 120
           DALDKQHRTALHLAC SGHV+VVTLLVNRKCQID+ DKENRTPLIQAVHCQEEACAVILL
Sbjct: 61  DALDKQHRTALHLACTSGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILL 120

Query: 121 EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEK 180
           EHGANPNLKDIYGNTALHYAVYSESTSLAEKLL HG +IEALDKD+NTPLLFAIICKKEK
Sbjct: 121 EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEK 180

Query: 181 MVEFLLKNKASTHAVDRLRXTALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAI 240
           MVEFLLK KAS+HAVDRLR +ALMLAV+YDS GIVNILLKQ+I+VF QDMCGRDAEDYAI
Sbjct: 181 MVEFLLKKKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAI 240

Query: 241 SCRLTKIQQQILEHKKMILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQC 300
           S  LTKIQQQILEHKK ILK +K DVGSSDESAVSIFHEL VDSL A DD+ L+VA KQC
Sbjct: 241 SHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQC 300

Query: 301 VPEKVSEPLRGPSHGKGNRIVNGKGEGPPAKHPSLKPSTEMEDPAVKGAVQXKNVQTLRA 360
           VPEKVSEPL G SH KGNRIVNG+GEGPPAKHPSLKPSTE+EDPAVKGAVQ KNVQTLRA
Sbjct: 301 VPEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRA 360

Query: 361 EQALPVASEEEQQRRERSEKKQPQVIEGNNTYKSEKIQLSENICHSTFSAAADRLTQQRK 420
           EQALPVASEEEQ+R ERSEKKQPQV EGNNT KSEKIQLSENIC ST SAAA RLTQQRK
Sbjct: 361 EQALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK 420

Query: 421 IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLHKKNREELERKEKQYKKEVEAKQLE 480
           IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNML+KKNREELERKEKQYKKEVEAKQLE
Sbjct: 421 IGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLE 480

Query: 481 PTVQSLEMKPKTARNTPNQDFHNHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKEN 540
           PTVQSLEMK KTARNTPN DFHNHEE+K LMDENCILK DIAILRQEICTMKNDNLEKEN
Sbjct: 481 PTVQSLEMKSKTARNTPNWDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKEN 540

Query: 541 KYLKDIKIAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAENTRLNSELLKEKESKK 600
           KYLKDIKI KETNAALEK IKLNEEMIT+TAF YQQELNDLKAENTRLN+ELLKEKESKK
Sbjct: 541 KYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKK 600

Query: 601 KLEAEIESYQSRLAAAISKHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFL 660
           +LEA+IESYQSRLAAAISKHSE+VKTERNLKLALERT+D+S QV+MSS IS+++ +N FL
Sbjct: 601 RLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKAENEFL 660

Query: 661 TEQLSKMQIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKV 720
           TEQLS+ QIKFN LKDKFRKTRD+LRKKSLALETVQNDLSQTQQQ +EMKEMYQ+AEAKV
Sbjct: 661 TEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKV 720

Query: 721 SKSTGKWNCVEERICQLQRENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEE 780
           + STGKWNCVEERIC LQREN WL QQL DVHQKEDHKEIV NIQRGFIES KKDL+LEE
Sbjct: 721 NNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEE 780

Query: 781 KNKKLMNEYDHLKESLFQYERQKAETVVSIKEDKYFQTSRKKV 823
           K+KKLMNE DHLKESLFQYER+K E VVSIKEDKYFQTSRK +
Sbjct: 781 KSKKLMNECDHLKESLFQYEREKTEGVVSIKEDKYFQTSRKTI 823


>gi|239746016 PREDICTED: ankyrin repeat domain 62 isoform 1 [Homo
           sapiens]
          Length = 917

 Score =  459 bits (1180), Expect = e-129
 Identities = 311/841 (36%), Positives = 463/841 (55%), Gaps = 66/841 (7%)

Query: 22  YTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDLDALDKQHRTALHLACASGHVK 81
           ++  GYR+R  +L  IHKAA+ GD  ++   +  R  DL+  DK++RTAL LACA G   
Sbjct: 27  FSNPGYRVRQKDLGMIHKAAIAGDVNKVMESILLRLNDLNDRDKKNRTALLLACAHGRPG 86

Query: 82  VVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALHYAV 141
           VV  LV RKCQ+++ D ENRT LI+AV CQEE CA ILLEHGANPN++D+YGNTALHYA+
Sbjct: 87  VVADLVARKCQLNLTDSENRTALIKAVQCQEEVCASILLEHGANPNVRDMYGNTALHYAI 146

Query: 142 YSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEKMVEFLLKNKASTHAVDRLRXT 201
            +E+ S+A KLL +G +IEA  +D +T LL A+  KKE+MV FLLK K    A+D    T
Sbjct: 147 DNENISMARKLLAYGADIEARSQDGHTSLLLAVNRKKEQMVAFLLKKKPDLTAIDNFGRT 206

Query: 202 ALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAISCRLTKIQQQILEHK------ 255
           AL+LA    S  +V  LL+ +I+VF QD+ G  AEDYA++ +   I+  I E+K      
Sbjct: 207 ALILAARNGSTSVVYQLLQHNIDVFCQDISGWTAEDYAVASKFQAIRGMISEYKANKRCK 266

Query: 256 KMILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQCVPEK--VSEPLRGPS 313
            +   N + D+  + E       E C  S   +++++     K+C  +K  VS  +    
Sbjct: 267 SLQNSNSEQDLEMTSEGEQERL-EGCESSQPQVEEKM-----KKCRNKKMEVSRNVHADD 320

Query: 314 HGKGN----RIVNGKGEGPPAKHPS----------LKPSTEMEDPAVKGAVQXKN----- 354
               N     +++      P  H S          L   T  E   VK  +   +     
Sbjct: 321 SDNYNDDVDELIHKIKNRKPDNHQSPGKENGEFDRLARKTSNEKSKVKSQIYFTDDLNDI 380

Query: 355 ---VQTLRAEQALPVASEE------EQQRRERSEKKQPQVIEGNNTYKSEKIQLSENICH 405
               +    +  LP + +E      EQ   E  +       +         I+  +  C 
Sbjct: 381 SGSSEKTSEDDELPYSDDENFMLLIEQSGMECKDFVSLSKSKNATAACGRSIEDQKCYCE 440

Query: 406 ST---FSAAADRLTQQRKI----GKTYPQQFPKKLKEEHDRCTLK----QENEEKTNVNM 454
                F    + ++  +K+     KT  Q   + L+ +   C L+    Q+ EE+     
Sbjct: 441 RLKVKFQKMKNNISVLQKVLSETDKTKSQSEHQNLQGKKKLCNLRFILQQQEEERIKAEE 500

Query: 455 LHKKNREELERKEKQYKKEVEAK-QLEPTVQSLEMKPKTARNTPNQDFHNHEEVKDLMDE 513
           L++K+ EEL+  E+QY+ + E K Q + T++SLE++ KT R+  NQ+FH HE  +DL  E
Sbjct: 501 LYEKDIEELKIMEEQYRTQTEVKKQSKLTLKSLEVELKTVRSNSNQNFHTHERERDLWQE 560

Query: 514 NCILKTDIAILRQEICTMKNDNLEKENKYLKDIKIAKETNAALEKCIKLNEEMITKTAFW 573
           N +++ +IA LR EI T+K+ N E ENKY KDI+I KE N  LEK +K NEE +TKT   
Sbjct: 561 NHLMRDEIARLRLEIDTIKHQNQETENKYFKDIEIIKENNEDLEKTLKRNEEALTKTITR 620

Query: 574 YQQELNDLKAENTRLNSELLKEKESKKKLEAEIESYQSRLAAAISKHSENVKTERNLKLA 633
           Y +ELN L  ENT LNSEL KEK+S  +LE E+ESY+ RLAAA+  H +   ++R+L+LA
Sbjct: 621 YSKELNVLMDENTMLNSELQKEKQSMSRLETEMESYRCRLAAALCDHDQRQSSKRDLQLA 680

Query: 634 LERTQDISEQVKMSSDI-SEIEDKNXFLTEQLSKMQIKFNTLKDKFRKTRDTLRKKSLAL 692
            + T  ++E   +  D  S I+     L++QLSK +   + L+ +    R+ L++K+L +
Sbjct: 681 FQST--VNEWCHLQEDTNSHIQ----ILSQQLSKAESTSSGLETELHYEREALKEKTLHI 734

Query: 693 ETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKWNCVEERICQLQRENPWLEQQLVDVH 752
           E +Q  LS+TQ+++++++ MYQ+ +  + K   K   VE+ + QLQ +N   +QQ  D  
Sbjct: 735 EHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQQSVEDGLFQLQSQNLLYQQQCNDAR 794

Query: 753 QKEDHKE-IVINIQ---RGFIESRKKDL-MLEEKNKKLMNEYDHLKESLFQYERQKAETV 807
           +K D++E  +INIQ      +E  + +   LEE NK LM E   LKE   QYE++K E  
Sbjct: 795 KKADNQEKTIINIQVKCEDTVEKLQAECRKLEENNKGLMKECTLLKERQCQYEKEKEERE 854

Query: 808 V 808
           V
Sbjct: 855 V 855


>gi|239756999 PREDICTED: ankyrin repeat domain 62 [Homo sapiens]
          Length = 917

 Score =  458 bits (1178), Expect = e-128
 Identities = 309/841 (36%), Positives = 464/841 (55%), Gaps = 66/841 (7%)

Query: 22  YTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDLDALDKQHRTALHLACASGHVK 81
           ++  GYR+R  +L  IHKAA+ GD  ++   +  R  DL+  DK++RTAL LACA G   
Sbjct: 27  FSNPGYRVRQKDLGMIHKAAIAGDVNKVMESILLRLNDLNDRDKKNRTALLLACAHGRPG 86

Query: 82  VVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALHYAV 141
           VV  LV RKCQ+++ D ENRT LI+AV CQEE CA ILLEHGANPN++D+YGNTALHYA+
Sbjct: 87  VVADLVARKCQLNLTDSENRTALIKAVQCQEEVCASILLEHGANPNVRDMYGNTALHYAI 146

Query: 142 YSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEKMVEFLLKNKASTHAVDRLRXT 201
            +E+ S+A KLL +G +IEA  +D +T LL A+  KKE+MV FLLK K    A+D    T
Sbjct: 147 DNENISMARKLLAYGADIEARSQDGHTSLLLAVNRKKEQMVSFLLKKKPDLTAIDNFGRT 206

Query: 202 ALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAISCRLTKIQQQILEH------K 255
           AL+LA    S  +V  LL+ +I+VF QD+ G  AEDYA++ +   I+  I E+      K
Sbjct: 207 ALILAARNGSTSVVYQLLQHNIDVFCQDISGWTAEDYAVASKFQAIRGMISEYKANKRRK 266

Query: 256 KMILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQCVPEK--VSEPLRGPS 313
            +   N + D+  + E       E C  S   +++++     K+C  +K  VS  +    
Sbjct: 267 SLQNSNSEQDLEMTSEGEQERL-EGCESSQPQVEEKM-----KKCRNKKMEVSRNVHADD 320

Query: 314 HGKGN----RIVNGKGEGPPAKHPS----------LKPSTEMEDPAVKGAVQXKN----- 354
               N     +++      P  H S          L   T  E   VK  +   +     
Sbjct: 321 SDNYNDDVDELIHKIKNRKPDNHQSPGKENGEFDRLARKTSNEKSKVKSQIYFTDDLNDI 380

Query: 355 ---VQTLRAEQALPVASEEEQQRRERSE----KKQPQVIEGNNTYKSEKIQLSENICHST 407
               +    +  LP + +E      +      K    + +  N   +    + +  C+  
Sbjct: 381 SGSSEKTSEDDELPYSDDENFMLLIKQSGMECKDFVSLSKSKNATAACGRSIEDQKCYCE 440

Query: 408 -----FSAAADRLTQQRKI----GKTYPQQFPKKLKEEHDRCTLK----QENEEKTNVNM 454
                F    + ++  +K+     KT  Q   + L+ +   C L+    Q+ EE+     
Sbjct: 441 RLKVKFQKMKNNISVLQKVLSETDKTKSQSEHQNLQGKKKLCNLRFILQQQEEERIKAEE 500

Query: 455 LHKKNREELERKEKQYKKEVEAK-QLEPTVQSLEMKPKTARNTPNQDFHNHEEVKDLMDE 513
           L++K+ EEL+  E+QY+ + E K Q + T++SLE++ KT R+  NQ+FH HE  +DL  E
Sbjct: 501 LYEKDIEELKIMEEQYRTQTEVKKQSKLTLKSLEVELKTVRSNSNQNFHTHERERDLWQE 560

Query: 514 NCILKTDIAILRQEICTMKNDNLEKENKYLKDIKIAKETNAALEKCIKLNEEMITKTAFW 573
           N +++ +IA LR EI T+K+ N E ENKY KDI+I KE N  LEK +K NEE +TKT   
Sbjct: 561 NHLMRDEIARLRLEIDTIKHQNQETENKYFKDIEIIKENNEDLEKTLKRNEETLTKTITR 620

Query: 574 YQQELNDLKAENTRLNSELLKEKESKKKLEAEIESYQSRLAAAISKHSENVKTERNLKLA 633
           Y +ELN L  ENT LNSEL KEK+S  +LE E+ESY+ RLAAA+  H +   ++R+L+LA
Sbjct: 621 YSKELNVLMDENTMLNSELQKEKQSMSRLETEMESYRCRLAAALCDHDQRQSSKRDLQLA 680

Query: 634 LERTQDISEQVKMSSDI-SEIEDKNXFLTEQLSKMQIKFNTLKDKFRKTRDTLRKKSLAL 692
            + T  ++E   +  D  S I+     L++QLSK +   + L+ +    R+ L++K+L +
Sbjct: 681 FQST--VNEWCHLQEDTNSHIQ----ILSQQLSKAESTSSGLETELHYEREALKEKTLHI 734

Query: 693 ETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKWNCVEERICQLQRENPWLEQQLVDVH 752
           E +Q  LS+TQ+++++++ MYQ+ +  + K   K   VE+ + QLQ +N   +QQ  D  
Sbjct: 735 EHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQQSVEDGLFQLQSQNLLYQQQCNDAR 794

Query: 753 QKEDHKE-IVINIQ---RGFIESRKKDL-MLEEKNKKLMNEYDHLKESLFQYERQKAETV 807
           +K D++E  +INIQ      +E  + +   LEE NK LM E   LKE   QYE++K E  
Sbjct: 795 KKADNQEKTIINIQVKCEDTVEKLQAECRKLEENNKGLMKECTLLKERQCQYEKEKEERE 854

Query: 808 V 808
           V
Sbjct: 855 V 855


>gi|239751514 PREDICTED: ankyrin repeat domain 62 isoform 4 [Homo
           sapiens]
          Length = 917

 Score =  458 bits (1178), Expect = e-128
 Identities = 309/841 (36%), Positives = 464/841 (55%), Gaps = 66/841 (7%)

Query: 22  YTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDLDALDKQHRTALHLACASGHVK 81
           ++  GYR+R  +L  IHKAA+ GD  ++   +  R  DL+  DK++RTAL LACA G   
Sbjct: 27  FSNPGYRVRQKDLGMIHKAAIAGDVNKVMESILLRLNDLNDRDKKNRTALLLACAHGRPG 86

Query: 82  VVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALHYAV 141
           VV  LV RKCQ+++ D ENRT LI+AV CQEE CA ILLEHGANPN++D+YGNTALHYA+
Sbjct: 87  VVADLVARKCQLNLTDSENRTALIKAVQCQEEVCASILLEHGANPNVRDMYGNTALHYAI 146

Query: 142 YSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEKMVEFLLKNKASTHAVDRLRXT 201
            +E+ S+A KLL +G +IEA  +D +T LL A+  KKE+MV FLLK K    A+D    T
Sbjct: 147 DNENISMARKLLAYGADIEARSQDGHTSLLLAVNRKKEQMVSFLLKKKPDLTAIDNFGRT 206

Query: 202 ALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAISCRLTKIQQQILEH------K 255
           AL+LA    S  +V  LL+ +I+VF QD+ G  AEDYA++ +   I+  I E+      K
Sbjct: 207 ALILAARNGSTSVVYQLLQHNIDVFCQDISGWTAEDYAVASKFQAIRGMISEYKANKRRK 266

Query: 256 KMILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQCVPEK--VSEPLRGPS 313
            +   N + D+  + E       E C  S   +++++     K+C  +K  VS  +    
Sbjct: 267 SLQNSNSEQDLEMTSEGEQERL-EGCESSQPQVEEKM-----KKCRNKKMEVSRNVHADD 320

Query: 314 HGKGN----RIVNGKGEGPPAKHPS----------LKPSTEMEDPAVKGAVQXKN----- 354
               N     +++      P  H S          L   T  E   VK  +   +     
Sbjct: 321 SDNYNDDVDELIHKIKNRKPDNHQSPGKENGEFDRLARKTSNEKSKVKSQIYFTDDLNDI 380

Query: 355 ---VQTLRAEQALPVASEEEQQRRERSE----KKQPQVIEGNNTYKSEKIQLSENICHST 407
               +    +  LP + +E      +      K    + +  N   +    + +  C+  
Sbjct: 381 SGSSEKTSEDDELPYSDDENFMLLIKQSGMECKDFVSLSKSKNATAACGRSIEDQKCYCE 440

Query: 408 -----FSAAADRLTQQRKI----GKTYPQQFPKKLKEEHDRCTLK----QENEEKTNVNM 454
                F    + ++  +K+     KT  Q   + L+ +   C L+    Q+ EE+     
Sbjct: 441 RLKVKFQKMKNNISVLQKVLSETDKTKSQSEHQNLQGKKKLCNLRFILQQQEEERIKAEE 500

Query: 455 LHKKNREELERKEKQYKKEVEAK-QLEPTVQSLEMKPKTARNTPNQDFHNHEEVKDLMDE 513
           L++K+ EEL+  E+QY+ + E K Q + T++SLE++ KT R+  NQ+FH HE  +DL  E
Sbjct: 501 LYEKDIEELKIMEEQYRTQTEVKKQSKLTLKSLEVELKTVRSNSNQNFHTHERERDLWQE 560

Query: 514 NCILKTDIAILRQEICTMKNDNLEKENKYLKDIKIAKETNAALEKCIKLNEEMITKTAFW 573
           N +++ +IA LR EI T+K+ N E ENKY KDI+I KE N  LEK +K NEE +TKT   
Sbjct: 561 NHLMRDEIARLRLEIDTIKHQNQETENKYFKDIEIIKENNEDLEKTLKRNEETLTKTITR 620

Query: 574 YQQELNDLKAENTRLNSELLKEKESKKKLEAEIESYQSRLAAAISKHSENVKTERNLKLA 633
           Y +ELN L  ENT LNSEL KEK+S  +LE E+ESY+ RLAAA+  H +   ++R+L+LA
Sbjct: 621 YSKELNVLMDENTMLNSELQKEKQSMSRLETEMESYRCRLAAALCDHDQRQSSKRDLQLA 680

Query: 634 LERTQDISEQVKMSSDI-SEIEDKNXFLTEQLSKMQIKFNTLKDKFRKTRDTLRKKSLAL 692
            + T  ++E   +  D  S I+     L++QLSK +   + L+ +    R+ L++K+L +
Sbjct: 681 FQST--VNEWCHLQEDTNSHIQ----ILSQQLSKAESTSSGLETELHYEREALKEKTLHI 734

Query: 693 ETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKWNCVEERICQLQRENPWLEQQLVDVH 752
           E +Q  LS+TQ+++++++ MYQ+ +  + K   K   VE+ + QLQ +N   +QQ  D  
Sbjct: 735 EHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQQSVEDGLFQLQSQNLLYQQQCNDAR 794

Query: 753 QKEDHKE-IVINIQ---RGFIESRKKDL-MLEEKNKKLMNEYDHLKESLFQYERQKAETV 807
           +K D++E  +INIQ      +E  + +   LEE NK LM E   LKE   QYE++K E  
Sbjct: 795 KKADNQEKTIINIQVKCEDTVEKLQAECRKLEENNKGLMKECTLLKERQCQYEKEKEERE 854

Query: 808 V 808
           V
Sbjct: 855 V 855


>gi|239741279 PREDICTED: similar to FLJ00310 protein [Homo sapiens]
          Length = 561

 Score =  370 bits (951), Expect = e-102
 Identities = 242/511 (47%), Positives = 306/511 (59%), Gaps = 60/511 (11%)

Query: 265 DVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQCVPEKVSEPLRGPSHGKGNRIVNGK 324
           DVG SDESAVSI HELCVDSL  LDDE LSVA KQCVPEKVSEPLRGPSH KGNRIVNGK
Sbjct: 54  DVGISDESAVSILHELCVDSLPTLDDEDLSVATKQCVPEKVSEPLRGPSHEKGNRIVNGK 113

Query: 325 GEGPPAKHPSLKPSTEMEDPAVKGAVQXKNVQTLRAEQALPVASEEEQQRRERSEKKQPQ 384
           G+GPPAKHPSLKPSTE+EDPAVKGAVQ KNVQTLRAEQ LPVA EEEQ+R ERSEKKQ Q
Sbjct: 114 GKGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQTLPVALEEEQERCERSEKKQSQ 173

Query: 385 VIEGNNTYKSEKIQLSENICHSTFSAAADRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQ 444
           V EGNNT KSEKIQLSEN+CHST SAAADRLT+QRK+GKTYPQQFPKKLK+EHD      
Sbjct: 174 VKEGNNTNKSEKIQLSENVCHSTSSAAADRLTKQRKVGKTYPQQFPKKLKKEHD------ 227

Query: 445 ENEEKTNVNMLHKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKPKTARNTPNQ--DFH 502
                          REELERKEKQYKKEVEAKQLEPTVQSL+MK KT RNTPNQ     
Sbjct: 228 ---------------REELERKEKQYKKEVEAKQLEPTVQSLDMKLKTTRNTPNQINQSL 272

Query: 503 NHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKENKYLKDIKIAKETNAALEKCIKL 562
            + + K +   N     D++  +Q+I  MK      EN   K      + +   E+  +L
Sbjct: 273 RYSQKKVIGFRNS--PNDLSQTQQQIKEMKE---MYENAEAKVNNSTGKWSCVEERICQL 327

Query: 563 NEEMITKTAFWYQQELNDL--KAENTRLNSEL-----------LKEKESKKKLEAEIESY 609
             E         +Q+L+D+  K ++  + + +           L  +E  KKL  E +  
Sbjct: 328 QHENPC-----IEQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNECDHL 382

Query: 610 QSRLAAAISKHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFLTE-QLSKMQ 668
           +  L     + +E V   R L+   E    + +   + S +  I   +  L E Q+ K +
Sbjct: 383 KESLFQYEREKAERVVVVRQLQ--QEAADSLKKLTMLESPLEGISHYHINLDETQVPKKK 440

Query: 669 I-KFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKW 727
           + +  +  D F   ++ +  K + L     ++   QQ++  MK++ Q  E    K     
Sbjct: 441 LFQVESQFDDFMAEKEAVSSKCVNL---AKEIQVFQQELLSMKKVQQECE----KLEEDK 493

Query: 728 NCVEERICQLQRENPWLEQQLVDVHQKEDHK 758
             +EE I  L+     +E  +V++ + +++K
Sbjct: 494 KMLEEEILNLKTH---MENSMVELSKLQEYK 521



 Score =  213 bits (542), Expect = 6e-55
 Identities = 128/263 (48%), Positives = 163/263 (61%), Gaps = 26/263 (9%)

Query: 575 QQELNDLKAENT---RLNSELLKEKESKKKLEAEIESYQSRLAAAISKHSENV------- 624
           ++ +  L+AE T    L  E  + + S+KK     E   +  +  I   SENV       
Sbjct: 141 RKNVQTLRAEQTLPVALEEEQERCERSEKKQSQVKEGNNTNKSEKIQL-SENVCHSTSSA 199

Query: 625 ---KTERNLKLALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKMQIK--FNTLKDKFR 679
              +  +  K+     Q   +++K   D  E+E K     +++   Q++    +L  K +
Sbjct: 200 AADRLTKQRKVGKTYPQQFPKKLKKEHDREELERKEKQYKKEVEAKQLEPTVQSLDMKLK 259

Query: 680 KTRDT----------LRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKWNC 729
            TR+T           +KK +      NDLSQTQQQIKEMKEMY++AEAKV+ STGKW+C
Sbjct: 260 TTRNTPNQINQSLRYSQKKVIGFRNSPNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSC 319

Query: 730 VEERICQLQRENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEEKNKKLMNEY 789
           VEERICQLQ ENP +EQQL DVHQKEDHKEIV NIQRGFIES KKDLMLEEKNKKLMNE 
Sbjct: 320 VEERICQLQHENPCIEQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNEC 379

Query: 790 DHLKESLFQYERQKAETVVSIKE 812
           DHLKESLFQYER+KAE VV +++
Sbjct: 380 DHLKESLFQYEREKAERVVVVRQ 402


>gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
          Length = 1363

 Score =  358 bits (918), Expect = 1e-98
 Identities = 271/805 (33%), Positives = 396/805 (49%), Gaps = 120/805 (14%)

Query: 2   KLFGFRSRRGQTVLGSIDHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDLD 61
           KL  F  R GQ +L S+D  Y G GY IR  EL+KIH+AA+KGDAAE+E CL RR  DLD
Sbjct: 102 KLLSFGRRLGQALLSSMDQEYAGRGYHIRDWELRKIHRAAIKGDAAEVEHCLTRRFRDLD 161

Query: 62  ALDKQHRTALHLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILLE 121
             DK+ RT LHLACA G V+VVTLL++RKCQI+I D+ NRTPL++AVHCQEEACA+ILL+
Sbjct: 162 VRDKKDRTVLHLACAHGRVQVVTLLLDRKCQINICDRLNRTPLMKAVHCQEEACAIILLK 221

Query: 122 HGANPNLKDIYGNTALHYAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEKM 181
            GANPN+KDIYGNTALHYAVY+E TSLAE+LL H  NIEAL+K+ NTPLLFAI  +++ M
Sbjct: 222 RGANPNIKDIYGNTALHYAVYNEGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHM 281

Query: 182 VEFLLKNKASTHAVDRLRXTALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAIS 241
           VEFLLKN+A+ HAVD  + TAL+LAV ++   IV +LL+Q+I++ +QDM G+ AEDYA  
Sbjct: 282 VEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIHISSQDMFGQTAEDYAFC 341

Query: 242 CRLTKIQQQILEHKKMILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQCV 301
           C L  IQQQILEHK  +LKN                           +D   + A K   
Sbjct: 342 CDLRSIQQQILEHKNKMLKN------------------------HLRNDNQETAAMK--- 374

Query: 302 PEKVSEPLRGPSHGKGNRIVNGKGEGPPAKHPSLKPSTEMEDPAVKGAVQXKNVQTLRAE 361
           PE + +        K  + +  + EG  A+H +LK ++E                     
Sbjct: 375 PENLKK-------RKKRKKLKKRKEGAKAEH-NLKVASE--------------------- 405

Query: 362 QALPVASEEEQQRRERSEKKQPQVIEGNNTYKSE---KIQLSENIC---HSTFSAAADRL 415
                   E+Q+R ERSE KQPQ  +     K E      L  +I       ++   D L
Sbjct: 406 --------EKQERLERSENKQPQDSQSYGKKKDEMFGNFMLKRDIAMLKEELYAIKNDSL 457

Query: 416 TQQRKIGKTYPQ------QFPKKLKEEHDRCTLK--QENEEKTNVNMLHKKNREELERKE 467
            +++K  +           F K ++   +  T K  Q +++  ++   + +   +LE KE
Sbjct: 458 RKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVAQYSQQLNDLKAENARLNSKLE-KE 516

Query: 468 KQYKKEVEAKQLEPTVQSLEMKPKTARNTPNQDFHNHEEVKDLMDENCILKTDIAILRQE 527
           K  K+ +EA+     V+SL     TA N        + E+ +  D   +L     + R E
Sbjct: 517 KHNKERLEAE-----VESLHSNLATAIN-------EYNEILERKDLELVLWRADDVSRHE 564

Query: 528 ICTMKNDNLEKENKYLKD--IKIAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAEN 585
                   L  +N+ L +   K   + N    K  +  + +  KT      +L DLK   
Sbjct: 565 TMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQL-DLKQAQ 623

Query: 586 TRLNSELLKEKESKKKLEAEIESYQSRLAAAISKHSENVKTERNLKLALERTQDISEQVK 645
            R+          + K    I    S       +  EN+  ER L+ A +   +    + 
Sbjct: 624 HRIKEMKQMHPNGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEIVIN 683

Query: 646 MSSDISEIEDKNXFLTEQLSKMQIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQ 705
           +  D  E   K   L E+  ++  ++N LK+K  +      ++ + +   Q +L      
Sbjct: 684 IHRDCLE-NGKEDLLEERNKELMNEYNYLKEKLLQYEKEKAEREVIVREFQEEL------ 736

Query: 706 IKEMKEMYQSAEAKVSKSTGKWNCVEERICQLQRENPWLEQQ---LVDVHQKEDHK---- 758
           +  +K+   S       S           C +  +  W  ++    V++  +E H+    
Sbjct: 737 VDHLKKFSMSESPLEGTSH----------CHINLDETWTSKKKLFQVEIQPEEKHEEFRK 786

Query: 759 --EIVINIQRGFIESRKKDLMLEEK 781
             E++  +     + RKK+  LEE+
Sbjct: 787 VFELISLLNYTADQIRKKNRELEEE 811



 Score =  328 bits (841), Expect = 1e-89
 Identities = 181/374 (48%), Positives = 261/374 (69%), Gaps = 8/374 (2%)

Query: 442 LKQENEEKTNV---NMLHKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKPKTARNTPN 498
           L+ +N+E   +   N+  +K R++L+++++  K E     L+   +  + + + + N   
Sbjct: 363 LRNDNQETAAMKPENLKKRKKRKKLKKRKEGAKAE---HNLKVASEEKQERLERSENKQP 419

Query: 499 QDFHNHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKENKYLKDIKIAKETNAALEK 558
           QD  ++ + KD M  N +LK DIA+L++E+  +KND+L KE KY+++IK   E NA  EK
Sbjct: 420 QDSQSYGKKKDEMFGNFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEK 479

Query: 559 CIKLNEEMITKTAFWYQQELNDLKAENTRLNSELLKEKESKKKLEAEIESYQSRLAAAIS 618
            ++LNEEMITK    Y Q+LNDLKAEN RLNS+L KEK +K++LEAE+ES  S LA AI+
Sbjct: 480 SVRLNEEMITKKVAQYSQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHSNLATAIN 539

Query: 619 KHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKMQIKFNTLKDKF 678
           +++E +   ++L+L L R  D+S    M S+IS++ DKN  LTEQ+ K ++KFNTLK K 
Sbjct: 540 EYNE-ILERKDLELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKL 598

Query: 679 RKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKWNCVEERICQLQ 738
           R+TRD LR+K+LALE+VQ DL Q Q +IKEMK+M+ + EAK S+S GK N  EERI Q +
Sbjct: 599 RETRDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKESQSIGKQNSSEERIRQRE 658

Query: 739 RENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEEKNKKLMNEYDHLKESLFQ 798
            EN  LE+QL D  ++ D+KEIVINI R  +E+ K+DL LEE+NK+LMNEY++LKE L Q
Sbjct: 659 LENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDL-LEERNKELMNEYNYLKEKLLQ 717

Query: 799 YERQKAETVVSIKE 812
           YE++KAE  V ++E
Sbjct: 718 YEKEKAEREVIVRE 731


>gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
          Length = 1366

 Score =  358 bits (918), Expect = 1e-98
 Identities = 271/805 (33%), Positives = 396/805 (49%), Gaps = 120/805 (14%)

Query: 2   KLFGFRSRRGQTVLGSIDHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDLD 61
           KL  F  R GQ +L S+D  Y G GY IR  EL+KIH+AA+KGDAAE+E CL RR  DLD
Sbjct: 131 KLLSFGRRLGQALLSSMDQEYAGRGYHIRDWELRKIHRAAIKGDAAEVEHCLTRRFRDLD 190

Query: 62  ALDKQHRTALHLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILLE 121
             DK+ RT LHLACA G V+VVTLL++RKCQI+I D+ NRTPL++AVHCQEEACA+ILL+
Sbjct: 191 VRDKKDRTVLHLACAHGRVQVVTLLLDRKCQINICDRLNRTPLMKAVHCQEEACAIILLK 250

Query: 122 HGANPNLKDIYGNTALHYAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEKM 181
            GANPN+KDIYGNTALHYAVY+E TSLAE+LL H  NIEAL+K+ NTPLLFAI  +++ M
Sbjct: 251 RGANPNIKDIYGNTALHYAVYNEGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHM 310

Query: 182 VEFLLKNKASTHAVDRLRXTALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAIS 241
           VEFLLKN+A+ HAVD  + TAL+LAV ++   IV +LL+Q+I++ +QDM G+ AEDYA  
Sbjct: 311 VEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIHISSQDMFGQTAEDYAFC 370

Query: 242 CRLTKIQQQILEHKKMILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQCV 301
           C L  IQQQILEHK  +LKN                           +D   + A K   
Sbjct: 371 CDLRSIQQQILEHKNKMLKN------------------------HLRNDNQETAAMK--- 403

Query: 302 PEKVSEPLRGPSHGKGNRIVNGKGEGPPAKHPSLKPSTEMEDPAVKGAVQXKNVQTLRAE 361
           PE + +        K  + +  + EG  A+H +LK ++E                     
Sbjct: 404 PENLKK-------RKKRKKLKKRKEGAKAEH-NLKVASE--------------------- 434

Query: 362 QALPVASEEEQQRRERSEKKQPQVIEGNNTYKSE---KIQLSENIC---HSTFSAAADRL 415
                   E+Q+R ERSE KQPQ  +     K E      L  +I       ++   D L
Sbjct: 435 --------EKQERLERSENKQPQDSQSYGKKKDEMFGNFMLKRDIAMLKEELYAIKNDSL 486

Query: 416 TQQRKIGKTYPQ------QFPKKLKEEHDRCTLK--QENEEKTNVNMLHKKNREELERKE 467
            +++K  +           F K ++   +  T K  Q +++  ++   + +   +LE KE
Sbjct: 487 RKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVAQYSQQLNDLKAENARLNSKLE-KE 545

Query: 468 KQYKKEVEAKQLEPTVQSLEMKPKTARNTPNQDFHNHEEVKDLMDENCILKTDIAILRQE 527
           K  K+ +EA+     V+SL     TA N        + E+ +  D   +L     + R E
Sbjct: 546 KHNKERLEAE-----VESLHSNLATAIN-------EYNEILERKDLELVLWRADDVSRHE 593

Query: 528 ICTMKNDNLEKENKYLKD--IKIAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAEN 585
                   L  +N+ L +   K   + N    K  +  + +  KT      +L DLK   
Sbjct: 594 TMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQL-DLKQAQ 652

Query: 586 TRLNSELLKEKESKKKLEAEIESYQSRLAAAISKHSENVKTERNLKLALERTQDISEQVK 645
            R+          + K    I    S       +  EN+  ER L+ A +   +    + 
Sbjct: 653 HRIKEMKQMHPNGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEIVIN 712

Query: 646 MSSDISEIEDKNXFLTEQLSKMQIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQ 705
           +  D  E   K   L E+  ++  ++N LK+K  +      ++ + +   Q +L      
Sbjct: 713 IHRDCLE-NGKEDLLEERNKELMNEYNYLKEKLLQYEKEKAEREVIVREFQEEL------ 765

Query: 706 IKEMKEMYQSAEAKVSKSTGKWNCVEERICQLQRENPWLEQQ---LVDVHQKEDHK---- 758
           +  +K+   S       S           C +  +  W  ++    V++  +E H+    
Sbjct: 766 VDHLKKFSMSESPLEGTSH----------CHINLDETWTSKKKLFQVEIQPEEKHEEFRK 815

Query: 759 --EIVINIQRGFIESRKKDLMLEEK 781
             E++  +     + RKK+  LEE+
Sbjct: 816 VFELISLLNYTADQIRKKNRELEEE 840



 Score =  328 bits (841), Expect = 1e-89
 Identities = 181/374 (48%), Positives = 261/374 (69%), Gaps = 8/374 (2%)

Query: 442 LKQENEEKTNV---NMLHKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKPKTARNTPN 498
           L+ +N+E   +   N+  +K R++L+++++  K E     L+   +  + + + + N   
Sbjct: 392 LRNDNQETAAMKPENLKKRKKRKKLKKRKEGAKAE---HNLKVASEEKQERLERSENKQP 448

Query: 499 QDFHNHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKENKYLKDIKIAKETNAALEK 558
           QD  ++ + KD M  N +LK DIA+L++E+  +KND+L KE KY+++IK   E NA  EK
Sbjct: 449 QDSQSYGKKKDEMFGNFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEK 508

Query: 559 CIKLNEEMITKTAFWYQQELNDLKAENTRLNSELLKEKESKKKLEAEIESYQSRLAAAIS 618
            ++LNEEMITK    Y Q+LNDLKAEN RLNS+L KEK +K++LEAE+ES  S LA AI+
Sbjct: 509 SVRLNEEMITKKVAQYSQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHSNLATAIN 568

Query: 619 KHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKMQIKFNTLKDKF 678
           +++E +   ++L+L L R  D+S    M S+IS++ DKN  LTEQ+ K ++KFNTLK K 
Sbjct: 569 EYNE-ILERKDLELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKL 627

Query: 679 RKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKWNCVEERICQLQ 738
           R+TRD LR+K+LALE+VQ DL Q Q +IKEMK+M+ + EAK S+S GK N  EERI Q +
Sbjct: 628 RETRDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKESQSIGKQNSSEERIRQRE 687

Query: 739 RENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEEKNKKLMNEYDHLKESLFQ 798
            EN  LE+QL D  ++ D+KEIVINI R  +E+ K+DL LEE+NK+LMNEY++LKE L Q
Sbjct: 688 LENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDL-LEERNKELMNEYNYLKEKLLQ 746

Query: 799 YERQKAETVVSIKE 812
           YE++KAE  V ++E
Sbjct: 747 YEKEKAEREVIVRE 760


>gi|239743705 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
          Length = 1139

 Score =  357 bits (915), Expect = 3e-98
 Identities = 270/805 (33%), Positives = 396/805 (49%), Gaps = 120/805 (14%)

Query: 2   KLFGFRSRRGQTVLGSIDHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDLD 61
           KL  F  R GQ +L S+D  Y G GY IR  EL+KIH+AA+KGDAAE+E CL RR  DLD
Sbjct: 131 KLLSFGRRLGQALLSSMDQEYAGRGYHIRDWELRKIHRAAIKGDAAEVEHCLTRRFRDLD 190

Query: 62  ALDKQHRTALHLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILLE 121
             D++ RT LHLACA G V+VVTLL++RKCQI+I D+ NRTPL++AVHCQEEACA+ILL+
Sbjct: 191 VRDRKDRTVLHLACAHGRVQVVTLLLDRKCQINICDRLNRTPLMKAVHCQEEACAIILLK 250

Query: 122 HGANPNLKDIYGNTALHYAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEKM 181
            GANPN+KDIYGNTALHYAVY+E TSLAE+LL H  NIEAL+K+ NTPLLFAI  +++ M
Sbjct: 251 RGANPNIKDIYGNTALHYAVYNEGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHM 310

Query: 182 VEFLLKNKASTHAVDRLRXTALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAIS 241
           VEFLLKN+A+ HAVD  + TAL+LAV ++   IV +LL+Q+I++ +QDM G+ AEDYA  
Sbjct: 311 VEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIHISSQDMFGQTAEDYAFC 370

Query: 242 CRLTKIQQQILEHKKMILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQCV 301
           C L  IQQQILEHK  +LKN                           +D   + A K   
Sbjct: 371 CDLRSIQQQILEHKNKMLKN------------------------HLRNDNQETAAMK--- 403

Query: 302 PEKVSEPLRGPSHGKGNRIVNGKGEGPPAKHPSLKPSTEMEDPAVKGAVQXKNVQTLRAE 361
           PE + +        K  + +  + EG  A+H +LK ++E                     
Sbjct: 404 PENLKK-------RKKRKKLKKRKEGAKAEH-NLKVASE--------------------- 434

Query: 362 QALPVASEEEQQRRERSEKKQPQVIEGNNTYKSE---KIQLSENIC---HSTFSAAADRL 415
                   E+Q+R ERSE KQPQ  +     K E      L  +I       ++   D L
Sbjct: 435 --------EKQERLERSENKQPQDSQSYGKKKDEMFGNFMLKRDIAMLKEELYAIKNDSL 486

Query: 416 TQQRKIGKTYPQ------QFPKKLKEEHDRCTLK--QENEEKTNVNMLHKKNREELERKE 467
            +++K  +           F K ++   +  T K  Q +++  ++   + +   +LE KE
Sbjct: 487 RKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVAQYSQQLNDLKAENARLNSKLE-KE 545

Query: 468 KQYKKEVEAKQLEPTVQSLEMKPKTARNTPNQDFHNHEEVKDLMDENCILKTDIAILRQE 527
           K  K+ +EA+     V+SL     TA N        + E+ +  D   +L     + R E
Sbjct: 546 KHNKERLEAE-----VESLHSNLATAIN-------EYNEILERKDLELVLWRADDVSRHE 593

Query: 528 ICTMKNDNLEKENKYLKD--IKIAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAEN 585
                   L  +N+ L +   K   + N    K  +  + +  KT      +L DLK   
Sbjct: 594 TMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQL-DLKQAQ 652

Query: 586 TRLNSELLKEKESKKKLEAEIESYQSRLAAAISKHSENVKTERNLKLALERTQDISEQVK 645
            R+          + K    I    S       +  EN+  ER L+ A +   +    + 
Sbjct: 653 HRIKEMKQMHPNGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEIVIN 712

Query: 646 MSSDISEIEDKNXFLTEQLSKMQIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQ 705
           +  D  E   K   L E+  ++  ++N LK+K  +      ++ + +   Q +L      
Sbjct: 713 IHRDCLE-NGKEDLLEERNKELMNEYNYLKEKLLQYEKEKAEREVIVREFQEEL------ 765

Query: 706 IKEMKEMYQSAEAKVSKSTGKWNCVEERICQLQRENPWLEQQ---LVDVHQKEDHK---- 758
           +  +K+   S       S           C +  +  W  ++    V++  +E H+    
Sbjct: 766 VDHLKKFSMSESPLEGTSH----------CHINLDETWTSKKKLFQVEIQPEEKHEEFRK 815

Query: 759 --EIVINIQRGFIESRKKDLMLEEK 781
             E++  +     + RKK+  LEE+
Sbjct: 816 VFELISLLNYTADQIRKKNRELEEE 840



 Score =  328 bits (841), Expect = 1e-89
 Identities = 181/374 (48%), Positives = 261/374 (69%), Gaps = 8/374 (2%)

Query: 442 LKQENEEKTNV---NMLHKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKPKTARNTPN 498
           L+ +N+E   +   N+  +K R++L+++++  K E     L+   +  + + + + N   
Sbjct: 392 LRNDNQETAAMKPENLKKRKKRKKLKKRKEGAKAE---HNLKVASEEKQERLERSENKQP 448

Query: 499 QDFHNHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKENKYLKDIKIAKETNAALEK 558
           QD  ++ + KD M  N +LK DIA+L++E+  +KND+L KE KY+++IK   E NA  EK
Sbjct: 449 QDSQSYGKKKDEMFGNFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEK 508

Query: 559 CIKLNEEMITKTAFWYQQELNDLKAENTRLNSELLKEKESKKKLEAEIESYQSRLAAAIS 618
            ++LNEEMITK    Y Q+LNDLKAEN RLNS+L KEK +K++LEAE+ES  S LA AI+
Sbjct: 509 SVRLNEEMITKKVAQYSQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHSNLATAIN 568

Query: 619 KHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKMQIKFNTLKDKF 678
           +++E +   ++L+L L R  D+S    M S+IS++ DKN  LTEQ+ K ++KFNTLK K 
Sbjct: 569 EYNE-ILERKDLELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKL 627

Query: 679 RKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKWNCVEERICQLQ 738
           R+TRD LR+K+LALE+VQ DL Q Q +IKEMK+M+ + EAK S+S GK N  EERI Q +
Sbjct: 628 RETRDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKESQSIGKQNSSEERIRQRE 687

Query: 739 RENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEEKNKKLMNEYDHLKESLFQ 798
            EN  LE+QL D  ++ D+KEIVINI R  +E+ K+DL LEE+NK+LMNEY++LKE L Q
Sbjct: 688 LENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDL-LEERNKELMNEYNYLKEKLLQ 746

Query: 799 YERQKAETVVSIKE 812
           YE++KAE  V ++E
Sbjct: 747 YEKEKAEREVIVRE 760


>gi|239755047 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
          Length = 1415

 Score =  353 bits (906), Expect = 4e-97
 Identities = 306/936 (32%), Positives = 461/936 (49%), Gaps = 133/936 (14%)

Query: 2    KLFGFRSRRGQTVLGSIDHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDLD 61
            KLF F  R GQ +L S+D  Y G GY IR  EL+KIH+AA+KGDAAE+ERCL RR  DLD
Sbjct: 110  KLFSFGRRLGQALLSSMDQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLD 169

Query: 62   ALDKQHRTALHLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILLE 121
            A D++ RT LHLACA G V+VVTLL++R+CQIDI D+ NRTPL++AVH QEEACA++LLE
Sbjct: 170  ARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLE 229

Query: 122  HGANPNLKDIYGNTALHYAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEKM 181
             GANPN++DIYGNTALHYAVY++ TSLAE+LL H  NIEAL+K+ NTPLLFAI  +++ M
Sbjct: 230  CGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHM 289

Query: 182  VEFLLKNKASTHAVDRLRXTALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAIS 241
            VEFLLKN+A+ HAVD  + TAL+LAV ++   IV +LL+Q+I + +QDM G+ AEDYA+ 
Sbjct: 290  VEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALC 349

Query: 242  CRLTKIQQQILEHKKMILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQ-- 299
              L  I+QQILEHK  +LKN   +   + E+A      L      A  +  L VA+++  
Sbjct: 350  SDLRSIRQQILEHKNKMLKNHLRN--DNQETAAMKPANLKKRKERAKAEHNLKVASEEKQ 407

Query: 300  --CVPEKVSEPLRGPSHGKGNRIVNG-----------KGEGPPAKHPSL----------K 336
                  +  +P    S+GK    + G           K E    K+ SL          K
Sbjct: 408  ERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIK 467

Query: 337  PSTEMEDPAVKG------------AVQXKNVQTLRAEQA-LPVASEEEQQRRERSEKKQP 383
              TE+     K             A   + +  L+AE A L    E+E+  +ER E +  
Sbjct: 468  SITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVE 527

Query: 384  QVIEGNNTYKSEKIQLSENICHSTFSAAADRLTQQRKIGKTYPQQFPKKLKEEHDRCTLK 443
             +     T  +E  ++ E          AD +++  K+G    Q     L ++++  T +
Sbjct: 528  SLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNISQ-----LTDKNELLT-E 581

Query: 444  QENEEKTNVNMLHKKNRE---------------ELERKEKQYKKEVEAKQLEPTVQSLEM 488
            Q ++ +   N L  K RE               +L+ ++ Q++ + E KQ+ P  ++ E 
Sbjct: 582  QVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIK-EMKQMHPNGEAKES 640

Query: 489  KPKTARNTPNQDFHNHE--------EVKDLMDENCILKTDIAILRQEICTMKNDNLEKEN 540
            +    +N+  +     E        +++D   E    +  I I R  +   K D LE+ N
Sbjct: 641  QSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERN 700

Query: 541  KYLKDIKIAKETNAALEKCIKLNEEMITKTAF--WYQQELND-LKA---------ENTRL 588
            K     ++ KE N   EK ++  +E   +      +Q+EL D LK            +  
Sbjct: 701  K-----ELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHC 755

Query: 589  NSELLKEKESKKKL-EAEIE---------------SYQSRLAAAISKHSENVKTE-RNLK 631
            +  L +   SKKKL + EI+               S  +  A  I K +  ++ E    K
Sbjct: 756  HINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYK 815

Query: 632  LALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKMQIKFNTLKDKFR------------ 679
              LE T ++      + D S   D N   T+QL KM I F  LK KF             
Sbjct: 816  KCLEMTINMLNAF-ANEDFSCHGDLN---TDQL-KMDILFKKLKQKFNDLVAEKEAVSSE 870

Query: 680  -----KTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKWNCVEERI 734
                 K  + L ++ L++  VQ    + ++  K ++E   + +  + K   +   ++E  
Sbjct: 871  CVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYK 930

Query: 735  CQLQRENPWLEQQLVDVH---QKEDHKEIVINIQRGFIESRKKDLMLEE---KNKKLMNE 788
             +L        ++L ++H   Q E  K++    +      +KK+L L++   K  K+   
Sbjct: 931  SELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSKMKTA 990

Query: 789  YDHLKESLFQYERQKAETV-VSIKEDKYFQTSRKKV 823
            Y+ +   L +++   A  V  +    K    S KK+
Sbjct: 991  YEEVTTELEEFKEAFAGAVKANNSMSKKLMKSDKKI 1026


>gi|239749578 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
          Length = 1002

 Score =  353 bits (906), Expect = 4e-97
 Identities = 306/936 (32%), Positives = 461/936 (49%), Gaps = 133/936 (14%)

Query: 2   KLFGFRSRRGQTVLGSIDHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDLD 61
           KLF F  R GQ +L S+D  Y G GY IR  EL+KIH+AA+KGDAAE+ERCL RR  DLD
Sbjct: 3   KLFSFGRRLGQALLSSMDQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLD 62

Query: 62  ALDKQHRTALHLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILLE 121
           A D++ RT LHLACA G V+VVTLL++R+CQIDI D+ NRTPL++AVH QEEACA++LLE
Sbjct: 63  ARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLE 122

Query: 122 HGANPNLKDIYGNTALHYAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEKM 181
            GANPN++DIYGNTALHYAVY++ TSLAE+LL H  NIEAL+K+ NTPLLFAI  +++ M
Sbjct: 123 CGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHM 182

Query: 182 VEFLLKNKASTHAVDRLRXTALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAIS 241
           VEFLLKN+A+ HAVD  + TAL+LAV ++   IV +LL+Q+I + +QDM G+ AEDYA+ 
Sbjct: 183 VEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALC 242

Query: 242 CRLTKIQQQILEHKKMILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQ-- 299
             L  I+QQILEHK  +LKN   +   + E+A      L      A  +  L VA+++  
Sbjct: 243 SDLRSIRQQILEHKNKMLKNHLRN--DNQETAAMKPANLKKRKERAKAEHNLKVASEEKQ 300

Query: 300 --CVPEKVSEPLRGPSHGKGNRIVNG-----------KGEGPPAKHPSL----------K 336
                 +  +P    S+GK    + G           K E    K+ SL          K
Sbjct: 301 ERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIK 360

Query: 337 PSTEMEDPAVKG------------AVQXKNVQTLRAEQA-LPVASEEEQQRRERSEKKQP 383
             TE+     K             A   + +  L+AE A L    E+E+  +ER E +  
Sbjct: 361 SITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVE 420

Query: 384 QVIEGNNTYKSEKIQLSENICHSTFSAAADRLTQQRKIGKTYPQQFPKKLKEEHDRCTLK 443
            +     T  +E  ++ E          AD +++  K+G    Q     L ++++  T +
Sbjct: 421 SLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNISQ-----LTDKNELLT-E 474

Query: 444 QENEEKTNVNMLHKKNRE---------------ELERKEKQYKKEVEAKQLEPTVQSLEM 488
           Q ++ +   N L  K RE               +L+ ++ Q++ + E KQ+ P  ++ E 
Sbjct: 475 QVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIK-EMKQMHPNGEAKES 533

Query: 489 KPKTARNTPNQDFHNHE--------EVKDLMDENCILKTDIAILRQEICTMKNDNLEKEN 540
           +    +N+  +     E        +++D   E    +  I I R  +   K D LE+ N
Sbjct: 534 QSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERN 593

Query: 541 KYLKDIKIAKETNAALEKCIKLNEEMITKTAF--WYQQELND-LKA---------ENTRL 588
           K     ++ KE N   EK ++  +E   +      +Q+EL D LK            +  
Sbjct: 594 K-----ELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHC 648

Query: 589 NSELLKEKESKKKL-EAEIE---------------SYQSRLAAAISKHSENVKTE-RNLK 631
           +  L +   SKKKL + EI+               S  +  A  I K +  ++ E    K
Sbjct: 649 HINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYK 708

Query: 632 LALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKMQIKFNTLKDKFR------------ 679
             LE T ++      + D S   D N   T+QL KM I F  LK KF             
Sbjct: 709 KCLEMTINMLNAF-ANEDFSCHGDLN---TDQL-KMDILFKKLKQKFNDLVAEKEAVSSE 763

Query: 680 -----KTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKWNCVEERI 734
                K  + L ++ L++  VQ    + ++  K ++E   + +  + K   +   ++E  
Sbjct: 764 CVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYK 823

Query: 735 CQLQRENPWLEQQLVDVH---QKEDHKEIVINIQRGFIESRKKDLMLEE---KNKKLMNE 788
            +L        ++L ++H   Q E  K++    +      +KK+L L++   K  K+   
Sbjct: 824 SELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSKMKTA 883

Query: 789 YDHLKESLFQYERQKAETV-VSIKEDKYFQTSRKKV 823
           Y+ +   L +++   A  V  +    K    S KK+
Sbjct: 884 YEEVTTELEEFKEAFAGAVKANNSMSKKLMKSDKKI 919


>gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
          Length = 1415

 Score =  353 bits (906), Expect = 4e-97
 Identities = 306/936 (32%), Positives = 461/936 (49%), Gaps = 133/936 (14%)

Query: 2    KLFGFRSRRGQTVLGSIDHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDLD 61
            KLF F  R GQ +L S+D  Y G GY IR  EL+KIH+AA+KGDAAE+ERCL RR  DLD
Sbjct: 110  KLFSFGRRLGQALLSSMDQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLD 169

Query: 62   ALDKQHRTALHLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILLE 121
            A D++ RT LHLACA G V+VVTLL++R+CQIDI D+ NRTPL++AVH QEEACA++LLE
Sbjct: 170  ARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLE 229

Query: 122  HGANPNLKDIYGNTALHYAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEKM 181
             GANPN++DIYGNTALHYAVY++ TSLAE+LL H  NIEAL+K+ NTPLLFAI  +++ M
Sbjct: 230  CGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHM 289

Query: 182  VEFLLKNKASTHAVDRLRXTALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAIS 241
            VEFLLKN+A+ HAVD  + TAL+LAV ++   IV +LL+Q+I + +QDM G+ AEDYA+ 
Sbjct: 290  VEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALC 349

Query: 242  CRLTKIQQQILEHKKMILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQ-- 299
              L  I+QQILEHK  +LKN   +   + E+A      L      A  +  L VA+++  
Sbjct: 350  SDLRSIRQQILEHKNKMLKNHLRN--DNQETAAMKPANLKKRKERAKAEHNLKVASEEKQ 407

Query: 300  --CVPEKVSEPLRGPSHGKGNRIVNG-----------KGEGPPAKHPSL----------K 336
                  +  +P    S+GK    + G           K E    K+ SL          K
Sbjct: 408  ERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIK 467

Query: 337  PSTEMEDPAVKG------------AVQXKNVQTLRAEQA-LPVASEEEQQRRERSEKKQP 383
              TE+     K             A   + +  L+AE A L    E+E+  +ER E +  
Sbjct: 468  SITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVE 527

Query: 384  QVIEGNNTYKSEKIQLSENICHSTFSAAADRLTQQRKIGKTYPQQFPKKLKEEHDRCTLK 443
             +     T  +E  ++ E          AD +++  K+G    Q     L ++++  T +
Sbjct: 528  SLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNISQ-----LTDKNELLT-E 581

Query: 444  QENEEKTNVNMLHKKNRE---------------ELERKEKQYKKEVEAKQLEPTVQSLEM 488
            Q ++ +   N L  K RE               +L+ ++ Q++ + E KQ+ P  ++ E 
Sbjct: 582  QVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIK-EMKQMHPNGEAKES 640

Query: 489  KPKTARNTPNQDFHNHE--------EVKDLMDENCILKTDIAILRQEICTMKNDNLEKEN 540
            +    +N+  +     E        +++D   E    +  I I R  +   K D LE+ N
Sbjct: 641  QSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERN 700

Query: 541  KYLKDIKIAKETNAALEKCIKLNEEMITKTAF--WYQQELND-LKA---------ENTRL 588
            K     ++ KE N   EK ++  +E   +      +Q+EL D LK            +  
Sbjct: 701  K-----ELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHC 755

Query: 589  NSELLKEKESKKKL-EAEIE---------------SYQSRLAAAISKHSENVKTE-RNLK 631
            +  L +   SKKKL + EI+               S  +  A  I K +  ++ E    K
Sbjct: 756  HINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYK 815

Query: 632  LALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKMQIKFNTLKDKFR------------ 679
              LE T ++      + D S   D N   T+QL KM I F  LK KF             
Sbjct: 816  KCLEMTINMLNAF-ANEDFSCHGDLN---TDQL-KMDILFKKLKQKFNDLVAEKEAVSSE 870

Query: 680  -----KTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKWNCVEERI 734
                 K  + L ++ L++  VQ    + ++  K ++E   + +  + K   +   ++E  
Sbjct: 871  CVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYK 930

Query: 735  CQLQRENPWLEQQLVDVH---QKEDHKEIVINIQRGFIESRKKDLMLEE---KNKKLMNE 788
             +L        ++L ++H   Q E  K++    +      +KK+L L++   K  K+   
Sbjct: 931  SELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSKMKTA 990

Query: 789  YDHLKESLFQYERQKAETV-VSIKEDKYFQTSRKKV 823
            Y+ +   L +++   A  V  +    K    S KK+
Sbjct: 991  YEEVTTELEEFKEAFAGAVKANNSMSKKLMKSDKKI 1026


>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
          Length = 1710

 Score =  325 bits (833), Expect = 1e-88
 Identities = 195/444 (43%), Positives = 274/444 (61%), Gaps = 62/444 (13%)

Query: 431  KKLKEEHDRCTLK----QENEEKTNVNMLHKKNREELERKEKQYKKEVEAKQ-LEPTVQS 485
            +K++ E + C+L+    QE E++ N + L++K RE+L RKE+QY+KEVE KQ LE ++Q+
Sbjct: 780  QKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQT 839

Query: 486  LEMKPKTARNTPNQ---------------------------------------------- 499
            LEM+ +T ++  NQ                                              
Sbjct: 840  LEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSE 899

Query: 500  DFHNHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKENKYLKDIKIAKETNAALEKC 559
            + H+HEE KDL  +N +L+ +IA+LR EI T+KN N EKE K  +D+KI KE N  L+K 
Sbjct: 900  NSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKT 959

Query: 560  IKLNEEMITKTAFWYQQELNDLKAENTRLNSELLKEKESKKKLEAEIESYQSRLAAAISK 619
            IK NEE +T+T   Y   L+ L AEN  LNS+L  EK+SK++LEAE+ESY SRLAAAI  
Sbjct: 960  IKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHD 1019

Query: 620  HSENVKTERNLKLALERTQDISE--QVKMSSDISEIEDKNXFLTEQLSKMQIKFNTLKDK 677
              ++  ++R L+LA +R +D     Q KM+ D+S ++D N  L++QL K + K N+L+ +
Sbjct: 1020 RDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIE 1079

Query: 678  FRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKWNCVEERICQL 737
            F  TRD LR+K+L LE VQ DLSQTQ Q+KEM++ YQ+ + KV+K  GK   VEER+ QL
Sbjct: 1080 FHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQL 1139

Query: 738  QRENPWLEQQLVDVHQKEDHKE-IVINIQRGF--------IESRKKDLMLEEKNKKLMNE 788
            Q EN  L QQL D H K D+KE  VINIQ  F         ES K+ L+LEE+NK+L++E
Sbjct: 1140 QSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISE 1199

Query: 789  YDHLKESLFQYERQKAETVVSIKE 812
             +HLKE  +QYE +KAE  V +++
Sbjct: 1200 CNHLKERQYQYENEKAEREVVVRQ 1223



 Score =  215 bits (547), Expect = 2e-55
 Identities = 110/214 (51%), Positives = 151/214 (70%), Gaps = 15/214 (7%)

Query: 8   SRRGQTVLGSI---------------DHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERC 52
           S++G++ LGS                +  Y+  GY +R  +L KIHKAA  G+ A++++ 
Sbjct: 6   SKKGESPLGSFARRQRSSAGGGGEPGEGAYSQPGYHVRDRDLGKIHKAASAGNVAKVQQI 65

Query: 53  LARRSGDLDALDKQHRTALHLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQE 112
           L  R   L+  DK +RTALHLACA+GH +VVTLLV+RKCQ+++ D ENRT L++AV CQE
Sbjct: 66  LLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQE 125

Query: 113 EACAVILLEHGANPNLKDIYGNTALHYAVYSESTSLAEKLLFHGENIEALDKDSNTPLLF 172
           E CA ILLEHGA+PNL D++GNTALHYAVY+E  S+A KLL +  NIEA +KD  TPLL 
Sbjct: 126 EKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLL 185

Query: 173 AIICKKEKMVEFLLKNKASTHAVDRLRXTALMLA 206
           A+  KK++MVEFL+K KA+ +AVD+L  +  +++
Sbjct: 186 AVSGKKQQMVEFLIKKKANVNAVDKLESSHQLIS 219



 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 151/672 (22%), Positives = 264/672 (39%), Gaps = 123/672 (18%)

Query: 237  DYAISCRLTKIQQQILEHKKMILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVA 296
            D   S  L +     L +   + KN++ D+     SA+ +  E  ++S    D E +S  
Sbjct: 375  DIIESAPLEQTNNDNLTYVDEVHKNNRSDM----MSALGLGQEEDIES--PWDSESIS-- 426

Query: 297  AKQCVPEKVSEPLRGPSHGKGNRIVNGKGE--------------------------GPPA 330
              +  P+K  +PL G + GK   I N + E                          G P 
Sbjct: 427  --ENFPQKYVDPLAGAADGKEKNIGNEQAEDVFYIPSCMSGSRNFKMAKLEDTRNVGMPV 484

Query: 331  KHPS-------LKPSTEMEDPAVKGAVQXKNVQTLRA-EQALPVASEEEQQRRERSEKKQ 382
             H         LKP+ EM+D     A   K+VQT +A E  L VASEEEQ+R E SE  Q
Sbjct: 485  AHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAAEHDLEVASEEEQER-EGSENNQ 543

Query: 383  PQVIEGNNTYKSEKIQLSENICHSTFSAAA-----DRLTQQRKIGKTYPQQFPKKLKEEH 437
            PQV E    +++ ++++S NI       A      D L Q+RK G+T  QQFP+K  +E+
Sbjct: 544  PQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQFPRKENKEY 603

Query: 438  D-----------RCTLKQENEEKTNVN----------------MLHKKNREELERKEKQY 470
                        + T K++   K +VN                +    +  E++  E + 
Sbjct: 604  ASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGRP 663

Query: 471  KKEV--EAKQLEPTVQSLEMKPKTARN--TPNQDFH-NHEEVKDLM-----------DEN 514
             K+   E  +++  +QS++      ++  T ++D    H   K+ M           D  
Sbjct: 664  TKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECKDSV 723

Query: 515  CILK-TDIAILRQEICTMKNDNLE-----------KENKYLKDIKIAKETNAALEKCIKL 562
             +LK  D A+  + +  +K ++ E           K N   +++   KE  + LE     
Sbjct: 724  SLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVE 783

Query: 563  NEEMITKTAFWYQQELNDLKAENTRLNS--ELLKEKESKKKLEAEIESYQSRLAAAISKH 620
             E  +    F   QE    +  +T      E L+ KE + + E E++         +   
Sbjct: 784  WERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEME 843

Query: 621  SENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKM------QIKFNTL 674
               VK+  NL   ++   D   Q+    +   ++D    LT  LSK       Q K N+ 
Sbjct: 844  LRTVKS--NLNQVVQERNDAQRQLSREQNARMLQD--GILTNHLSKQKEIEMAQKKMNSE 899

Query: 675  KDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKWNCVEERI 734
                 +    L  K+  L   Q +++  + +I  +K   Q  E K  +       V+E+ 
Sbjct: 900  NSHSHEEEKDLSHKNSML---QEEIAMLRLEIDTIKNQNQEKEKKCFEDL---KIVKEKN 953

Query: 735  CQLQRENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEEKNKKLMNEYDHLKE 794
              LQ+     E+ L     + + +  V+  +   + S+ ++    ++  +   E  H + 
Sbjct: 954  EDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRL 1013

Query: 795  SLFQYERQKAET 806
            +   ++R ++ET
Sbjct: 1014 AAAIHDRDQSET 1025



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 103/501 (20%), Positives = 205/501 (40%), Gaps = 55/501 (10%)

Query: 338  STEMEDPAVKGAVQXKNVQTLRAEQALPVASEEEQQRRERSEKKQPQVIEGNNTY-KSEK 396
            S E+E    + A++ K +   R ++ L   S+ + Q +E  +K Q + ++ N    K E 
Sbjct: 1075 SLEIEFHHTRDALREKTLGLERVQKDL---SQTQCQMKEMEQKYQNEQVKVNKYIGKQES 1131

Query: 397  IQ------LSEN-ICHSTFSAAADRLTQQRKIGKTYPQQFP---KKLKEEHDRCTLKQEN 446
            ++       SEN +       A ++   + K       QF    +KL+ E ++ +L  E 
Sbjct: 1132 VEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEE 1191

Query: 447  EEKTNVNMLHKKNREELERKEKQYKKEVEAKQLE----PTVQSLEMKPKTARNTPNQDFH 502
              K  ++  +     + + + ++ ++EV  +QL+     T++   M   +   T     +
Sbjct: 1192 RNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRIN 1251

Query: 503  NHEEVKDLMDENCILKTDI---------AILRQEICTMKNDNLEKENKYLKDIKIAKETN 553
              +E +DL  +   ++  +         A+   E        LEK+N  LK + + K+  
Sbjct: 1252 LEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLK-VTVKKQ-- 1308

Query: 554  AALEKCIKLNEEMITKTAFWYQQE-LNDLKAENTRLNSELLKEKESKKKLEAEIESYQSR 612
              ++K  +L + ++       ++E L  L      L   L +E +   +LE EI  +++ 
Sbjct: 1309 --MDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNL 1366

Query: 613  LAAAISKHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKMQIKFN 672
            L     K +E    E +    L+     + Q +M   I++++ K   LT +L     K  
Sbjct: 1367 LKMTRKKLNEYENGEFSFHGDLK-----TSQFEMDIQINKLKHKIDDLTAELETAGSKCL 1421

Query: 673  TLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKE------------MYQSAEAKV 720
             L  K       L+++ L+++TVQ    + Q+  K++++            M +  + K 
Sbjct: 1422 HLDTK----NQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQ 1477

Query: 721  SKSTGKWNCVEERICQLQRENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEE 780
             K   +    +E   +L+  N +L+ Q       E  +E      +  +E R KDL  E 
Sbjct: 1478 YKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESEL 1537

Query: 781  KNKKLMNEYDHLKESLFQYER 801
               K   E D  K  L +Y++
Sbjct: 1538 SKIKTSQE-DFNKTELEKYKQ 1557



 Score = 35.4 bits (80), Expect = 0.22
 Identities = 31/131 (23%), Positives = 55/131 (41%), Gaps = 1/131 (0%)

Query: 137 LHYAVYSESTSLAEKLLFHGEN-IEALDKDSNTPLLFAIICKKEKMVEFLLKNKASTHAV 195
           +H A  + + +  +++L   +N +   DK + T L  A      ++V  L+  K   +  
Sbjct: 50  IHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVC 109

Query: 196 DRLRXTALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAISCRLTKIQQQILEHK 255
           D    TALM AV         ILL+   +    D+ G  A  YA+      +  ++L + 
Sbjct: 110 DNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYD 169

Query: 256 KMILKNDKPDV 266
             I   +K D+
Sbjct: 170 ANIEAKNKDDL 180


>gi|115495445 ankyrin repeat domain 30A [Homo sapiens]
          Length = 1341

 Score =  295 bits (756), Expect = 9e-80
 Identities = 192/529 (36%), Positives = 290/529 (54%), Gaps = 57/529 (10%)

Query: 328  PPAKHPSLKPSTEMEDPAVKGAVQXKNVQTLRAEQALPVASEEEQQRRE---------RS 378
            PP K  + +P+ EM+      A++ KN QTLRA+Q  P  SE +Q++ E         R 
Sbjct: 817  PPEKPSAFEPAIEMQKSVPNKALELKNEQTLRADQMFP--SESKQKKVEENSWDSESLRE 874

Query: 379  EKKQPQVIEGNNTYKSEKIQLSENICHST------------------------------- 407
               Q  V     T++ E  ++S  +  ST                               
Sbjct: 875  TVSQKDVCVPKATHQKEMDKISGKLEDSTSLSKILDTVHSCERARELQKDHCEQRTGKME 934

Query: 408  -----FSAAADRLTQQRKIGKTYPQQFPKKLKEEHDRC----TLKQENEEKTNVNMLHKK 458
                 F     +L++ ++I      Q   K+K E + C    TL QE E++ N ++L++K
Sbjct: 935  QMKKKFCVLKKKLSEAKEIKSQLENQ---KVKWEQELCSVRLTLNQEEEKRRNADILNEK 991

Query: 459  NREELERKEKQYKKEVEAKQ-LEPTVQSLEMKPKTARNTPNQDFHNHEEVKDLMDENCIL 517
             REEL R E+Q++KE+E KQ LE  ++  +++ K+  +  NQ  H HE    L+ ENC+L
Sbjct: 992  IREELGRIEEQHRKELEVKQQLEQALRIQDIELKSVESNLNQVSHTHENENYLLHENCML 1051

Query: 518  KTDIAILRQEICTMKNDNLEKENKYLKDIKIAKETNAALEKCIKLNEEMITKTAFWYQQE 577
            K +IA+L+ EI T+K+   EKENKY +DIKI KE NA L+  +KL EE +TK A  Y  +
Sbjct: 1052 KKEIAMLKLEIATLKHQYQEKENKYFEDIKILKEKNAELQMTLKLKEESLTKRASQYSGQ 1111

Query: 578  LNDLKAENTRLNSELLKEKESKKKLEAEIESYQSRLAAAISKHSENVKTERNLKLALERT 637
            L  L AENT L S+L KEK+ K+ LEAEIES+  RLA+A+  H + V + ++ + A    
Sbjct: 1112 LKVLIAENTMLTSKL-KEKQDKEILEAEIESHHPRLASAVQDHDQIVTSRKSQEPAFHIA 1170

Query: 638  QDISEQVKMSSDISEIEDKNXFLTEQLSKMQIKFNTLKDKFRKTRDTLRKKSLALETVQN 697
             D   Q KM+ D+S     N  L + LS+ Q K  +LK       D LR+ +L  E  Q 
Sbjct: 1171 GDACLQRKMNVDVSSTIYNNEVLHQPLSEAQRKSKSLKINLNYAGDALRENTLVSEHAQR 1230

Query: 698  DLSQTQQQIKEMKEMYQSAEAKVSKSTGKWNCVEERICQLQRENPWLEQQLVDVHQKEDH 757
            D  +TQ Q+KE + MYQ+ +  V+K T +   +++++ QLQ +N WL+QQLV  H+K D+
Sbjct: 1231 DQRETQCQMKEAEHMYQNEQDNVNKHTEQQESLDQKLFQLQSKNMWLQQQLVHAHKKADN 1290

Query: 758  KEIVINIQRGFIESRKKDLMLEEKNKKLMNEYDHLKESLFQYERQKAET 806
            K   I I   F+E + +  +L+EKN+++ N  +HLK  ++QYE++KAET
Sbjct: 1291 KS-KITIDIHFLERKMQHHLLKEKNEEIFNYNNHLKNRIYQYEKEKAET 1338



 Score =  213 bits (542), Expect = 6e-55
 Identities = 111/225 (49%), Positives = 158/225 (70%), Gaps = 6/225 (2%)

Query: 55  RRSGDLDALDKQHRTALHLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEA 114
           +++ +L+  D Q RTALH AC +GH +VVT LV+RKCQ+D+ D E+RTPL++A+ C +EA
Sbjct: 5   KKTINLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEA 64

Query: 115 CAVILLEHGANPNLKDIYGNTALHYAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAI 174
           CA IL++ GA+ NL D+YGNTALHYAVYSE  S+  KLL HG  IE  +K S TPLL +I
Sbjct: 65  CANILIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSI 124

Query: 175 ICKKEKMVEFLLKNKASTHAVDRLRXTALMLAVHYDSLGIVNILLKQSINVFTQDMCGRD 234
             + E++VEFLL   A+ +AV++ + TALMLAV + S  IV +LL+Q+++VF  D+CG  
Sbjct: 125 TKRSEQIVEFLLIKNANANAVNKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAADICGVT 184

Query: 235 AEDYAISCRLTKIQQQILEHKKMILKN------DKPDVGSSDESA 273
           AE YA++C    I +QI+E+ + + KN      +    G+ DE+A
Sbjct: 185 AEHYAVTCGFHHIHEQIMEYIRKLSKNHQNTNPEGTSAGTPDEAA 229



 Score = 66.6 bits (161), Expect = 9e-11
 Identities = 115/528 (21%), Positives = 205/528 (38%), Gaps = 66/528 (12%)

Query: 328  PPAKHPSLKPSTEMEDPAVKGAVQXKNVQTLRAEQALPVASEEEQQRRERSEKKQPQVIE 387
            PP K  + +P+TEM+      A++ KN QTLRA++ LP  SE +Q+  E +      + E
Sbjct: 579  PPGKPSAFEPATEMQKSVPNKALELKNEQTLRADEILP--SESKQKDYEENSWDTESLCE 636

Query: 388  GNNTYKSEKIQLSENICHSTFSAAADRLTQQ------RKIGKTYPQQFPKKLKEEHDRCT 441
               T   + + L +            +L          K         P K  E  D  T
Sbjct: 637  ---TVSQKDVCLPKAAHQKEIDKINGKLEGSPVKDGLLKANCGMKVSIPTKALELMDMQT 693

Query: 442  LKQENEEKTNV-------------NMLHKKNREEL--------ERKEKQYKKEV-EAKQL 479
             K E  EK +                L  KN + L        E K+K Y++   +++ L
Sbjct: 694  FKAEPPEKPSAFEPAIEMQKSVPNKALELKNEQTLRADEILPSESKQKDYEESSWDSESL 753

Query: 480  EPTVQSLEMKPKTARNTPNQDFHNH--EEVKD---LMDENCILKTDI---AILRQEICTM 531
              TV   ++    A +    D  N   EE  D    +   C +K  I   A+   ++ T 
Sbjct: 754  CETVSQKDVCLPKATHQKEIDKINGKLEESPDNDGFLKAPCRMKVSIPTKALELMDMQTF 813

Query: 532  KNDNLEKENKYLKDIKIAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAENTRLNSE 591
            K +  EK + +   I++ K   +   K ++L  E   +    +  E    K E    +SE
Sbjct: 814  KAEPPEKPSAFEPAIEMQK---SVPNKALELKNEQTLRADQMFPSESKQKKVEENSWDSE 870

Query: 592  LLKEKESKKKLEAEIESYQSRLAAAISKHSENVKTERNLKLALERTQDISEQVKMSSDIS 651
             L+E  S+K +     ++Q  +     K S  ++   +L   L+         ++  D  
Sbjct: 871  SLRETVSQKDVCVPKATHQKEM----DKISGKLEDSTSLSKILDTVHSCERARELQKDHC 926

Query: 652  EIEDKNXFLTEQLSKMQIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKE 711
            E        T ++ +M+ KF  LK K  + ++   +        + +L   +  + + +E
Sbjct: 927  EQR------TGKMEQMKKKFCVLKKKLSEAKEIKSQLENQKVKWEQELCSVRLTLNQEEE 980

Query: 712  MYQSAEAKVSKSTGKWNCVEERICQLQRENPWLEQQLVDVHQKED--HKEIVINIQRGFI 769
              ++A+    K   +   +EE+     R+   ++QQL    + +D   K +  N+ +   
Sbjct: 981  KRRNADILNEKIREELGRIEEQ----HRKELEVKQQLEQALRIQDIELKSVESNLNQVSH 1036

Query: 770  ESRKKDLMLEEKNKKLMNEYDHLKESLFQYERQKAETVVSIKEDKYFQ 817
                ++ +L E N  L  E   LK  +   + Q  E     KE+KYF+
Sbjct: 1037 THENENYLLHE-NCMLKKEIAMLKLEIATLKHQYQE-----KENKYFE 1078



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 138/621 (22%), Positives = 231/621 (37%), Gaps = 92/621 (14%)

Query: 243 RLTKIQQQILE--HKKMIL---KNDKPDVGSSD-----ESAVSIFHELCVDSLSALDDEL 292
           R+T  + ++LE    KMI    K       ++D     ES      E   DS S  +   
Sbjct: 377 RVTSNKTKVLEKGRSKMIACPTKESSTKASANDQRFPSESKQEEDEEYSCDSRSLFES-- 434

Query: 293 LSVAAKQCVPEKVSEPLRGPSHGKGNRIVNGKGEGPPAKHPSLKPSTEMEDPAVKGAVQX 352
            S   + C+PE + + +           +N + E PP K  + KP+ EM++     A + 
Sbjct: 435 -SAKIQVCIPESIYQKVME---------INREVEEPPKKPSAFKPAIEMQNSVPNKAFEL 484

Query: 353 KNVQTLRAEQALPVASEEEQQRRERSEKK-------QPQVIEGNNTYKSEKIQLSENICH 405
           KN QTLRA+   P  S+++       + +       Q  V     T++ E  +++  +  
Sbjct: 485 KNEQTLRADPMFPPESKQKDYEENSWDSESLCETVSQKDVCLPKATHQKEIDKINGKLEE 544

Query: 406 STFSAAADRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQENEEKTNV------------- 452
           S       + T   K+        P K  E  D  T K E   K +              
Sbjct: 545 SPNKDGLLKATCGMKV------SIPTKALELKDMQTFKAEPPGKPSAFEPATEMQKSVPN 598

Query: 453 NMLHKKNREEL--------ERKEKQYKKEV-EAKQLEPTVQSLEM-KPKTARNTPNQDFH 502
             L  KN + L        E K+K Y++   + + L  TV   ++  PK A        +
Sbjct: 599 KALELKNEQTLRADEILPSESKQKDYEENSWDTESLCETVSQKDVCLPKAAHQKEIDKIN 658

Query: 503 NHEE---VKD-LMDENCILKTDI---AILRQEICTMKNDNLEKENKYLKDIKIAKETNAA 555
              E   VKD L+  NC +K  I   A+   ++ T K +  EK + +   I++ K   + 
Sbjct: 659 GKLEGSPVKDGLLKANCGMKVSIPTKALELMDMQTFKAEPPEKPSAFEPAIEMQK---SV 715

Query: 556 LEKCIKLNEEMITKTAFWYQQELNDLKAENTRLNSELLKEKESKKKLEAEIESYQSRLAA 615
             K ++L  E   +       E      E +  +SE L E  S+K +     ++Q  +  
Sbjct: 716 PNKALELKNEQTLRADEILPSESKQKDYEESSWDSESLCETVSQKDVCLPKATHQKEIDK 775

Query: 616 AISKHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFLTEQLSK--------- 666
              K  E+   +  LK           +V + +   E+ D   F  E   K         
Sbjct: 776 INGKLEESPDNDGFLKAPCRM------KVSIPTKALELMDMQTFKAEPPEKPSAFEPAIE 829

Query: 667 MQIKFNTLKDKFRKTRDTLRKKSL-ALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTG 725
           MQ K    K    K   TLR   +   E+ Q  + +     + ++E     +  V K+T 
Sbjct: 830 MQ-KSVPNKALELKNEQTLRADQMFPSESKQKKVEENSWDSESLRETVSQKDVCVPKATH 888

Query: 726 KWNCVEERICQLQRENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRK-KDLMLEEKNKK 784
           +     ++I     ++  L + L  VH  E  +E    +Q+   E R  K   +++K   
Sbjct: 889 QKEM--DKISGKLEDSTSLSKILDTVHSCERARE----LQKDHCEQRTGKMEQMKKKFCV 942

Query: 785 LMNEYDHLKESLFQYERQKAE 805
           L  +    KE   Q E QK +
Sbjct: 943 LKKKLSEAKEIKSQLENQKVK 963


>gi|222537750 ankyrin repeat domain 30B [Homo sapiens]
          Length = 1392

 Score =  293 bits (751), Expect = 3e-79
 Identities = 195/556 (35%), Positives = 303/556 (54%), Gaps = 52/556 (9%)

Query: 283  DSLSALDDELLSVAAKQ---CVPEKVSEPLRGPSHGKGNRIVNGKGEGPPAKHPSLKPST 339
            D+ S  D E++SV+  Q   C+PE         ++ K  +  NGK E  P K    +P+T
Sbjct: 869  DTKSTSDSEIISVSDTQNYECLPEA--------TYQKEIKTTNGKIEESPEKPSHFEPAT 920

Query: 340  EMEDPAVKGAVQXKNVQTLRAEQ--------ALPVASEEEQQRRERSEKKQPQVIEGNNT 391
            EM++      ++ KN QTLRA+         ALP      + +++  E+   ++ +  N 
Sbjct: 921  EMQNSVPNKGLEWKNKQTLRADSTTLSKILDALPSCERGRELKKDNCEQITAKMEQTKNK 980

Query: 392  YKSEKIQLSENICHSTFSAAADRLTQQRKIGKTYPQQFPKKLKEEHDRC----TLKQENE 447
            +   + +LSE          A  +  Q +          +K K E + C    TL QE E
Sbjct: 981  FCVLQKELSE----------AKEIKSQLE---------NQKAKWEQELCSVRLTLNQEEE 1021

Query: 448  EKTNVNMLHKKNREELERKEKQYKKEVEAKQ-LEPTVQSLEMKPKTARNTPNQDFHNHEE 506
            ++ NV++L +K R E     +Q +K++E KQ LE T++  +++ K+  +  NQ  H HE 
Sbjct: 1022 KRRNVDILKEKIRPE-----EQLRKKLEVKQQLEQTLRIQDIELKSVTSNLNQVSHTHES 1076

Query: 507  VKDLMDENCILKTDIAILRQEICTMKNDNLEKENKYLKDIKIAKETNAALEKCIKLNEEM 566
              DL  ENC+LK +IA+L+ E+ T+K+ +  KENKY +DIKI +E NA L+  +KL ++ 
Sbjct: 1077 ENDLFHENCMLKKEIAMLKLEVATLKHQHQVKENKYFEDIKILQEKNAELQMTLKLKQKT 1136

Query: 567  ITKTAFWYQQELNDLKAENTRLNSELLKEKESKKKLEAEIESYQSRLAAAISKHSENVKT 626
            +TK A  Y+++L  L AENT L S+L KEK+ K+ LE EIES+  RLA+A+  H ++V +
Sbjct: 1137 VTKRASQYREQLKVLTAENTMLTSKL-KEKQDKEILETEIESHHPRLASALQDHDQSVTS 1195

Query: 627  ERNLKLALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKMQIKFNTLKDKFRKTRDTLR 686
             +N +LA     D   Q  M+ D+S     N  L + L + Q K  + K       D LR
Sbjct: 1196 RKNQELAFHSAGDAPLQGIMNVDVSNTIYNNEVLHQPLYEAQRKSKSPKINLNYAGDDLR 1255

Query: 687  KKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKWNCVEERICQLQRENPWLEQ 746
            + +L  E  Q D  +TQ Q+K+ + MYQ+ +  V K T +   +E+++ QL+ +N WL Q
Sbjct: 1256 ENALVSEHAQRDRCETQCQMKKAEHMYQNEQDNVDKHTEQQESLEQKLFQLESKNRWLRQ 1315

Query: 747  QLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEEKNKKLMNEYDHLKESLFQYERQKAET 806
            QLV  H+K +  ++ INIQ       K    L EKN+++ N  +HLKE + QYE++KAE 
Sbjct: 1316 QLVYAHKKVNKSKVTINIQ---FPEMKMQRHLNEKNEEVFNYGNHLKERIDQYEKEKAER 1372

Query: 807  VVSIKEDKYFQTSRKK 822
             VSIK+ KYF    K+
Sbjct: 1373 EVSIKKYKYFSNFLKE 1388



 Score =  217 bits (552), Expect = 4e-56
 Identities = 171/531 (32%), Positives = 265/531 (49%), Gaps = 63/531 (11%)

Query: 19  DHLYTGSGY-RIRYSELQKIHKAAVKGDAAEMERC-LARRSGDLDALDKQHRTALHLACA 76
           + +YT   Y  I + +L KIH AA +G   ++E+  + ++  +L+  D + RTALH AC 
Sbjct: 23  ERVYTEKDYGTIYFGDLGKIHTAASRGQVQKLEKMTVGKKPVNLNKRDMKKRTALHWACV 82

Query: 77  SGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTA 136
           +GH +VVT LV+RKCQ+++ D E RTPL++A+ C+ EACA IL++ GA+ N  D+YGNTA
Sbjct: 83  NGHAEVVTFLVDRKCQLNVLDGEGRTPLMKALQCEREACANILIDAGADLNYVDVYGNTA 142

Query: 137 LHYAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEKMVEFLLKNKASTHAVD 196
           LHYAVYSE+  +   LL +G  IE  +K S TPLL AI  + ++ VEFLL   A+ +A +
Sbjct: 143 LHYAVYSENLLMVATLLSYGAVIEVQNKASLTPLLLAIQKRSKQTVEFLLTKNANANAFN 202

Query: 197 RLRXTALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAISCRLTKIQQQILEHKK 256
             + TALMLA+   S  IV +LL+Q+++VF +D+ G  AE YA +C +  I QQ+LEH +
Sbjct: 203 ESKCTALMLAICEGSSEIVGMLLQQNVDVFAEDIHGITAERYAAACGVNYIHQQLLEHIR 262

Query: 257 MILKN------DKPDVGSSDESAVSIFHELCVDSLSALDDELLSVAAK---------QCV 301
            + KN      +    G+ DE+A     E   D+  +L ++    AA+         QC+
Sbjct: 263 KLPKNPQNTNPEGTSTGTPDEAAP--LAERTPDTAESLLEKTPDEAARLVEGTSAKIQCL 320

Query: 302 PEKVSEPLRGPSHGKGNRIVNGKGEGP-----PAKHPSLKPSTEMEDPAVK----GAVQX 352
            +  S      +     +I+    E       PAK  S K + E ++ +VK      V  
Sbjct: 321 GKATSGKFEQSTEETPRKILRPTKETSEKFSWPAKERSRKITWEEKETSVKTECVAGVTP 380

Query: 353 KNVQTLRAEQALPVASEEEQQRRERSEKKQPQVIE------GNNTYKSE---KIQLSENI 403
              + L    +  +A   ++   + S       +E      G  T ++    K++   N+
Sbjct: 381 NKTEVLEKGTSNMIACPTKETSTKASTNVDVSSVEPIFSLFGTRTIENSQCTKVEEDFNL 440

Query: 404 CHSTFSAAADR-------LTQQRKI----GKTYPQQFPKKLKEEHDR-----CTLKQENE 447
                S +A +        T Q+ I     K   Q FP + K E D           E+ 
Sbjct: 441 ATKIISKSAAQNYTCLPDATYQKDIKTINHKIEDQMFPSESKREEDEEYSWDSGSLFESS 500

Query: 448 EKTNV----NMLHK-----KNREELERKEKQYKKEVEAKQLEPTVQSLEMK 489
            KT V    +M  K     +  EEL  K   +K  VE ++  P  ++ E+K
Sbjct: 501 AKTQVCIPESMYQKVMEINREVEELPEKPSAFKPAVEMQKTVPN-KAFELK 550



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 115/555 (20%), Positives = 205/555 (36%), Gaps = 93/555 (16%)

Query: 294  SVAAKQCVPEKVSEPLRGPSHGKGNRIVNGKGEGPPAKHPSLKPSTEMEDPAVKGAVQXK 353
            S   + C+PE + + +           +N + E  P K  + KP+ EM+      A + K
Sbjct: 500  SAKTQVCIPESMYQKVME---------INREVEELPEKPSAFKPAVEMQKTVPNKAFELK 550

Query: 354  NVQTLRAEQALPVASEEEQQRRERSEKKQP-------QVIEGNNTYKSEKIQLSENICHS 406
            N QTLRA Q  P  S+++       + + P        V     T++ E   LS  +  S
Sbjct: 551  NEQTLRAAQMFPSESKQKDDEENSWDSESPCETVSQKDVYLPKATHQKEFDTLSGKLEES 610

Query: 407  TFSAAADRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQENEEKTNV-------------N 453
                   + T  RK+        P K  E  DR T K E+ +K  +              
Sbjct: 611  PVKDGLLKPTCGRKV------SLPNKALELKDRETFKAESPDKDGLLKPTCGRKVSLPNK 664

Query: 454  MLHKKNREELERKEKQ---YKKEVEAKQLEPTVQSLEMKP----KTARNTPNQDFHNHEE 506
             L  K+RE L+ +        K    +++    ++LE+K     K A+  P++     +E
Sbjct: 665  ALELKDRETLKAESPDNDGLLKPTCGRKVSLPNKALELKDRETFKAAQMFPSESKQKDDE 724

Query: 507  VKDLMDENCILKTDIAILRQEICTMKNDNLEKENKYLKDIKIAKETNAALEKCIKLNEEM 566
             ++  D    L+T   +L+ ++C  K  + ++ +     ++ + + +  L+    +   +
Sbjct: 725  -ENSWDFESFLET---LLQNDVCLPKATHQKEFDTLSGKLEESPDKDGLLKPTCGMKISL 780

Query: 567  ITKTAFWYQQELNDLKAENTRLNSELLKEKESKKKLEAEIESYQSRLAAAISKHSENVKT 626
              K                     EL   +  K +  + +ES  S      +++S++ K 
Sbjct: 781  PNKAL-------------------ELKDRETFKAEDVSSVESTFSLFGKPTTENSQSTKV 821

Query: 627  ERNLKLALERTQDISEQVKMSSDISEIE-----DKNXFLTEQLSKMQIKFNTLKDKFRKT 681
            E +  L  +     +   +   DI  IE       N   T +L + +   +T   +    
Sbjct: 822  EEDFNLTTKEGATKTVTGQQERDIGIIERAPQDQTNKMPTSELGRKEDTKSTSDSEIISV 881

Query: 682  RDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKWNCVEERICQLQREN 741
             DT   + L   T Q ++  T  +I+E  E     E     +T   N V  +  +     
Sbjct: 882  SDTQNYECLPEATYQKEIKTTNGKIEESPEKPSHFE----PATEMQNSVPNKGLE----- 932

Query: 742  PWLEQQLVDVHQKEDHK--EIVINIQRGFIESRKKD-------LMLEEKNK--KLMNEYD 790
             W  +Q +        K  + + + +RG     KKD        M + KNK   L  E  
Sbjct: 933  -WKNKQTLRADSTTLSKILDALPSCERG--RELKKDNCEQITAKMEQTKNKFCVLQKELS 989

Query: 791  HLKESLFQYERQKAE 805
              KE   Q E QKA+
Sbjct: 990  EAKEIKSQLENQKAK 1004


>gi|149363642 coiled-coil domain containing 144A [Homo sapiens]
          Length = 1427

 Score =  279 bits (714), Expect = 7e-75
 Identities = 189/481 (39%), Positives = 273/481 (56%), Gaps = 61/481 (12%)

Query: 396  KIQLSENICHSTFSAAADRLTQQRKIGKTYPQQFPKKLKEEHD-RCTLKQENEEKTNVNM 454
            K++  EN+     S   + L++ +K       Q  +  KE +D R  LKQENEEK N +M
Sbjct: 662  KLKQMENMV----SVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADM 717

Query: 455  LHKKNREELERKEKQYKKEVEAKQ-LEPTVQSLEMKPKTARN----------------TP 497
            L+ K+ E+L  KE++  K VE KQ L+  ++ L  + +T RN                + 
Sbjct: 718  LYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERNDAQKQLSE 777

Query: 498  NQDF---------------------------HNHEEVKDLMDENCILKTDIAILRQEICT 530
             QD                            H H++ KDL  E+C+L+ +IA+LR EI T
Sbjct: 778  EQDARILQDQILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDT 837

Query: 531  MKNDNLEKENKYLKDIKIAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAENTRLNS 590
            +KN N +KE KY +DI+  KE N  L+K IKLNEE +T+T   Y  +LN+L AEN  LNS
Sbjct: 838  IKNQNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNS 897

Query: 591  ELLKEKESKKKLEAEIESYQSRLAAAISKHSENVKTERNLKLALERTQD--ISEQVKMSS 648
            EL   K+++++LE E+ESY+ RLAAA+ +  +  +T R+LKL  +RT+   +    KM  
Sbjct: 898  ELENGKQNQERLEIEMESYRCRLAAAV-RDCDQSQTARDLKLDFQRTRQEWVRLHDKMKV 956

Query: 649  DISEIEDKNXFLTEQLSKMQIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKE 708
            D+S ++ KN  L+E+LS  + K N+L+ +   TRD L ++SL LE VQ DLSQTQ Q KE
Sbjct: 957  DMSGLQAKNEILSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKE 1016

Query: 709  MKEMYQSAEAKVSKSTGKWNCVEERICQLQRENPWLEQQLVDVHQKEDHKEIVIN-IQRG 767
             ++MYQ  ++K+ K   K   VEER+ QLQ EN  L QQL D H+K + +E   + IQ  
Sbjct: 1017 TEQMYQIEQSKLKKYIAKQESVEERLSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQ 1076

Query: 768  F--------IESRKKDLMLEEKNKKLMNEYDHLKESLFQYERQKAETVVSIKEDKYFQTS 819
            F         ES K+ L L+EKNK+LM+EY+HLKE + Q E++KA   + + E +    S
Sbjct: 1077 FHSAAKNLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETVPS 1136

Query: 820  R 820
            R
Sbjct: 1137 R 1137



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 96/477 (20%), Positives = 188/477 (39%), Gaps = 75/477 (15%)

Query: 369 EEEQQRRERSEKKQPQVIEGNNTYKSEKIQLSENI------CHSTFSAAADRLTQQRKIG 422
           EE QQ  ++ + +   + E     K E +QL +++        S  +  +  LT    +G
Sbjct: 493 EELQQDMQKFKNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSNSTELSGTLTDGTTVG 552

Query: 423 KT---YPQQFPKKLKEEHDRCTLKQENEEKTNVNMLHKKNREELERKEKQYKKEVEAKQL 479
                  QQ P+K   EHDR   K  NE+    N ++     E +  +     E+ ++  
Sbjct: 553 NDDDGLNQQIPRKENGEHDRPADKTSNEKNEVKNQIY----PEADFADSMEPSEIASEDC 608

Query: 480 EPT----------VQSLEMKPKTARNTPN-QD-FHNHEEVKDLMDENC--------ILKT 519
           E +          ++ L M+ K + + P  QD F   E +  L + +C         ++ 
Sbjct: 609 ELSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMEN 668

Query: 520 DIAILRQEICTMKNDNLEKENKYLKDIKIAKETNAALEKCIKLNEEMITKTAFWYQQELN 579
            +++L+ E+   K   L+ E   L+ I+  KE    L   +K   E        Y ++  
Sbjct: 669 MVSVLQNELSETKKTKLQLE---LQKIEWEKEL-YDLRLALKQENEEKRNADMLYNKDSE 724

Query: 580 DLKAENTRLNSELLKEKESKKKLEAEIESYQSRLAAAISKHSENVKTER-NLKLALERTQ 638
            L+          +KE+E  K +E      + +L   + +  + ++T R NL L ++   
Sbjct: 725 QLR----------IKEEECGKVVET-----KQQLKWNLRRLVKELRTVRNNLDLVVQERN 769

Query: 639 DISEQVKMSSDISEIED-------KNXFLTEQLSKMQIKFNTLKDKFRKTRDTLRKKSLA 691
           D  +Q+    D   ++D       K   +  +    +I     K+K     D + ++ +A
Sbjct: 770 DAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIA 829

Query: 692 LETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKWNCVE-------ERICQ-------L 737
           L  ++ D  + Q + KE K+ ++  EA   K+      ++       E I Q       L
Sbjct: 830 LLRLEIDTIKNQNKQKE-KKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNL 888

Query: 738 QRENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEEKNKKLMNEYDHLKE 794
             EN  L  +L +  Q ++  EI +   R  + +  +D    +  + L  ++   ++
Sbjct: 889 TAENKILNSELENGKQNQERLEIEMESYRCRLAAAVRDCDQSQTARDLKLDFQRTRQ 945



 Score = 31.6 bits (70), Expect = 3.1
 Identities = 15/32 (46%), Positives = 21/32 (65%)

Query: 353 KNVQTLRAEQALPVASEEEQQRRERSEKKQPQ 384
           +N ++  AEQ   + SEEEQ+R +  E KQPQ
Sbjct: 215 ENKESKEAEQDSELTSEEEQERLKGCENKQPQ 246


>gi|153791352 prostate, ovary, testis expressed protein on
           chromosome 2 [Homo sapiens]
          Length = 1075

 Score =  257 bits (657), Expect = 3e-68
 Identities = 197/600 (32%), Positives = 303/600 (50%), Gaps = 80/600 (13%)

Query: 19  DHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDLDALDKQHRTALHLACASG 78
           D  +    Y +R  +L K+H+AA  G     +  +  R  D++  DKQ RTALHLA A+G
Sbjct: 125 DSAFMEPRYHVRGEDLDKLHRAAWWGKVPRKDLIVMLRDTDVNKQDKQKRTALHLASANG 184

Query: 79  HVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALH 138
           + +VV LL++R+CQ+++ D + RT LI+AV CQE+ CA++LLEHG +PN+ D YGNT LH
Sbjct: 185 NSEVVKLLLDRRCQLNVLDNKKRTALIKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLH 244

Query: 139 YAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEKMVEFLLKNKASTHAVDRL 198
           YA+Y+E   +A+ LL +G +IE+ +K   TPLL  +  +K+++V+FL+K KA+ +A+DR 
Sbjct: 245 YAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRY 304

Query: 199 RXTALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAISCRLTKIQQQILEHK-KM 257
             TAL+LAV   S  IV++LL+Q+I+V +QD+ G+ A +YA+S     I Q + ++K K 
Sbjct: 305 GRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQ 364

Query: 258 ILK----NDKPD----VGSSDESAVSIFHELCVDSLSALDDELLSVAAKQCVPEKVSEPL 309
           +LK    N  P+    + S +ES      E       + + E+     ++   E+  +  
Sbjct: 365 MLKISSENSNPEQDLKLTSEEESQRFKGSENSQPEKMSQEPEINKDGDREV--EEEMKKH 422

Query: 310 RGPSHGKGNRIVNG--KGEGPPAKHPSLKPST------------------EMEDPAVKGA 349
              + G    + NG   G G     P  K  T                  E+     +  
Sbjct: 423 ESNNVGLLENLTNGVTAGNGDNGLIPQRKSRTPENQQFPDNESEEYHRICELLSDYKEKQ 482

Query: 350 VQXKNVQTLRAEQALPVASEEEQQRRERSEKKQPQ--------------------VIEGN 389
           +   + +    EQ L + SEEE QR + SE  QP+                     IE  
Sbjct: 483 MPKYSSENSNPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFMAIEEM 542

Query: 390 NTYKSEKIQLSENICH-STFSAAADRLTQQRKIGKTYPQQFPKKLKEEH----DRCTLKQ 444
             ++S  +   EN+ + +T     D L   RK      QQFP    EE+       T KQ
Sbjct: 543 KKHRSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHSDEQNDTQKQ 602

Query: 445 ENEEKTNVNMLHKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKPKTARNTPNQDFHNH 504
             EE+ N  +LH    E L  +EKQ    +E  +   +  SL  K +             
Sbjct: 603 FCEEQ-NTGILHD---EILIHEEKQ----IEVVEKMNSELSLSCKKE------------- 641

Query: 505 EEVKDLMDENCILKTDIAILRQEICTMKNDNLEKENKYLKDIKIAKETNAALEKCIKLNE 564
              KD++ EN  L+ +IA+LR E+ TMK+ +  +E KYL+DI+  K+ N  L K ++LNE
Sbjct: 642 ---KDILHENSTLREEIAMLRLELDTMKHQSQLREKKYLEDIESVKKRNDNLLKALQLNE 698


>gi|134133226 protein expressed in prostate, ovary, testis, and
           placenta 2 [Homo sapiens]
          Length = 1075

 Score =  256 bits (655), Expect = 5e-68
 Identities = 197/609 (32%), Positives = 302/609 (49%), Gaps = 98/609 (16%)

Query: 19  DHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDLDALDKQHRTALHLACASG 78
           D  +    Y +R  +L K+H+AA  G     +  +  R  D++  DKQ RTALHLA A+G
Sbjct: 125 DSAFMEPRYHVRGEDLDKLHRAAWWGKVPRKDLIVMLRDTDVNKKDKQKRTALHLASANG 184

Query: 79  HVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALH 138
           + +VV LL++R+CQ+++ D + RT LI+AV CQE+ CA++LLEHG +PN+ D YGNT LH
Sbjct: 185 NSEVVKLLLDRRCQLNVLDNKKRTALIKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLH 244

Query: 139 YAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEKMVEFLLKNKASTHAVDRL 198
           YA+Y+E   +A+ LL +G +IE+ +K   TPLL  +  +K+++V+FL+K KA+ +A+DR 
Sbjct: 245 YAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRY 304

Query: 199 RXTALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAISCRLTKIQQQILEHK-KM 257
             TAL+LAV   S  IV++LL+Q+I+V +QD+ G+ A +YA+S     I Q + ++K K 
Sbjct: 305 GRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQ 364

Query: 258 ILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQCVPEKVSEPL-------- 309
           +LK    +     E             L++ ++      ++   PEK+S+ L        
Sbjct: 365 MLKISSENSNPEQEL-----------KLTSEEESQRFKGSENSQPEKMSQELEINKDGDR 413

Query: 310 -------RGPSHGKG--NRIVNG--KGEGPPAKHPSLKPST------------------E 340
                  +  S+  G    + NG   G G     P  K  T                  E
Sbjct: 414 EVEEEMKKHESNNVGLLENLTNGVTAGNGDNGLIPQRKSRTPENQQFPDNESEEYHRICE 473

Query: 341 MEDPAVKGAVQXKNVQTLRAEQALPVASEEEQQRRERSEKKQPQ---------------- 384
           +     +  +   + +    EQ L + SEEE QR + SE  QP+                
Sbjct: 474 LLSDYKEKQMPKYSSENSNPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDREL 533

Query: 385 ----VIEGNNTYKSEKIQLSENICH-STFSAAADRLTQQRKIGKTYPQQFPKKLKEEH-- 437
                IE    + S  +   EN+ + +T     D L   RK      QQFP    EE+  
Sbjct: 534 ENFMAIEEMKKHGSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHS 593

Query: 438 --DRCTLKQENEEKTNVNMLHKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKPKTARN 495
                T KQ  EE+ N  +LH    E L  +EKQ    +E  +   +  SL  K +    
Sbjct: 594 DEQNDTQKQFCEEQ-NTGILHD---EILIHEEKQ----IEVVEKMNSELSLSCKKE---- 641

Query: 496 TPNQDFHNHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKENKYLKDIKIAKETNAA 555
                       KD++ EN  L+ +IA+LR E+ TMK+ +  +E KYL+DI+  K+ N  
Sbjct: 642 ------------KDVLHENSTLREEIAMLRLELDTMKHQSQLREKKYLEDIESVKKKNDN 689

Query: 556 LEKCIKLNE 564
           L K ++LNE
Sbjct: 690 LLKALQLNE 698


>gi|88953571 PREDICTED: similar to protein expressed in prostate,
           ovary, testis, and placenta 2 isoform 2 [Homo sapiens]
          Length = 1075

 Score =  253 bits (646), Expect = 5e-67
 Identities = 196/600 (32%), Positives = 300/600 (50%), Gaps = 80/600 (13%)

Query: 19  DHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDLDALDKQHRTALHLACASG 78
           D  +    Y +R  +L K+H+AA  G  A  +  +  R  D++  DKQ RTALHLA A+G
Sbjct: 125 DSAFVEPRYHVRREDLDKLHRAAWWGKVARKDLIVMLRDTDVNKQDKQKRTALHLASANG 184

Query: 79  HVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALH 138
           +  VV LL++R+CQ+++ D + RT L +AV CQE+ CA++LLEHG +PN+ D YGNT LH
Sbjct: 185 NSGVVKLLLDRRCQLNVLDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLH 244

Query: 139 YAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEKMVEFLLKNKASTHAVDRL 198
           YA+Y+E   +A+ LL +G +IE+ +K   TPLL  +  +K+++V+FL+K KA+ +A+DR 
Sbjct: 245 YAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRY 304

Query: 199 RXTALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAISCRLTKIQQQILEHK-KM 257
             TAL+LAV   S  IV++LL+Q+I+V +QD+ G+ A +YA+S     I Q + ++K K 
Sbjct: 305 GRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQ 364

Query: 258 ILK----NDKPD----VGSSDESAVSIFHELCVDSLSALDDELLSVAAKQCVPEKVSEPL 309
           +LK    N  P+    + S +ES      E       + + E+     ++   E+  +  
Sbjct: 365 MLKISSENSNPEQDLKLTSEEESQRFKGSENSQPEKMSQEPEINKDGDREV--EEEMKKH 422

Query: 310 RGPSHGKGNRIVNG--KGEGPPAKHPSLKPST------------------EMEDPAVKGA 349
              + G    + NG   G G     P  K  T                  E+     +  
Sbjct: 423 ESNNVGLLENLSNGVTAGNGDDGLIPQRKSRTPENQQFPDNESEEYHRICELVSDYKEKQ 482

Query: 350 VQXKNVQTLRAEQALPVASEEEQQRRERSEKKQPQ--------------------VIEGN 389
           +   + +    EQ L + SEEE QR + SE  QP+                     IE  
Sbjct: 483 MPKYSSENSNPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFMAIEEM 542

Query: 390 NTYKSEKIQLSENICH-STFSAAADRLTQQRKIGKTYPQQFPKKLKEEH----DRCTLKQ 444
             + S  +   EN+ + +T     D L   RK      QQFP    EE+       T KQ
Sbjct: 543 KKHGSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHSDEQNDTQKQ 602

Query: 445 ENEEKTNVNMLHKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKPKTARNTPNQDFHNH 504
             EE+ N  +LH    E L  +EKQ    +E  +   +  SL  K +             
Sbjct: 603 FCEEQ-NTGILHD---EILIHEEKQ----IEVVEKMNSELSLSCKKE------------- 641

Query: 505 EEVKDLMDENCILKTDIAILRQEICTMKNDNLEKENKYLKDIKIAKETNAALEKCIKLNE 564
              KD + EN  L+ +IA+LR E+ TMK+ +  ++ KYL+DI+  K+ N  L K ++LNE
Sbjct: 642 ---KDFLHENSTLREEIAMLRLELDTMKHQSQLRKKKYLEDIESVKKKNDNLLKALQLNE 698


>gi|113413200 PREDICTED: similar to protein expressed in prostate,
           ovary, testis, and placenta 2 [Homo sapiens]
          Length = 1038

 Score =  253 bits (645), Expect = 7e-67
 Identities = 195/600 (32%), Positives = 301/600 (50%), Gaps = 80/600 (13%)

Query: 19  DHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDLDALDKQHRTALHLACASG 78
           D  +    Y +R  +L K+H+AA  G  A  +  +  R  D++  DKQ RTALHLA A+G
Sbjct: 88  DSAFVEPRYHVRREDLDKLHRAAWWGKVARKDLIVMLRDTDVNKQDKQKRTALHLASANG 147

Query: 79  HVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALH 138
           +  VV LL++R+CQ+++ D + RT L +AV CQE+ CA++LLEHG +PN+ D YGNT LH
Sbjct: 148 NSGVVKLLLDRRCQLNVLDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLH 207

Query: 139 YAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEKMVEFLLKNKASTHAVDRL 198
           YA+Y+E   +A+ LL +G +IE+ +K   TPLL  +  +K+++V+FL+K KA+ +A+DR 
Sbjct: 208 YAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRY 267

Query: 199 RXTALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAISCRLTKIQQQILEHK-KM 257
             TAL+LAV   S  IV++LL+Q+I+V +QD+ G+ A +YA+S     I Q + ++K K 
Sbjct: 268 GRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQ 327

Query: 258 ILK----NDKPD----VGSSDESAVSIFHELCVDSLSALDDELLSVAAKQCVPEKVSEPL 309
           +LK    N  P+    + S +ES      E       + + E+     ++   E+  +  
Sbjct: 328 MLKISSENSNPEQDLKLTSEEESQRFKGSENSQPEKMSQEPEINKDGDREV--EEEMKKH 385

Query: 310 RGPSHGKGNRIVNG--KGEGPPAKHPSLKPST------------------EMEDPAVKGA 349
              + G    + NG   G G     P  K  T                  E+     +  
Sbjct: 386 ESNNVGLLENLSNGVTAGNGDDGLIPQRKSRTPENQQFPDNESEEYHRICELVSDYKEKQ 445

Query: 350 VQXKNVQTLRAEQALPVASEEEQQRRERSEKKQPQ--------------------VIEGN 389
           +   + +    EQ L + SEEE QR + SE  QP+                     IE  
Sbjct: 446 MPKYSSENSNPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFMAIEEM 505

Query: 390 NTYKSEKIQLSENICH-STFSAAADRLTQQRKIGKTYPQQFPKKLKEEH----DRCTLKQ 444
             + S  +   EN+ + +T     D L   RK      QQFP    EE+       T KQ
Sbjct: 506 KKHGSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHSDEQNDTQKQ 565

Query: 445 ENEEKTNVNMLHKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKPKTARNTPNQDFHNH 504
             EE+ N  +LH    E L  +EKQ    +E  +   +  SL  K +             
Sbjct: 566 FCEEQ-NTGILHD---EILIHEEKQ----IEVVEKMNSELSLSCKKE------------- 604

Query: 505 EEVKDLMDENCILKTDIAILRQEICTMKNDNLEKENKYLKDIKIAKETNAALEKCIKLNE 564
              +D + EN +L+ +IA+LR E+ TMK+ +  ++ KYL+DI+  K+ N  L K ++LNE
Sbjct: 605 ---RDFLHENSMLREEIAMLRLELDTMKHQSQLRKKKYLEDIESVKKKNDNLLKALQLNE 661


>gi|239741673 PREDICTED: protein immuno-reactive with anti-PTH
            polyclonal antibodies [Homo sapiens]
          Length = 1430

 Score =  252 bits (644), Expect = 9e-67
 Identities = 190/574 (33%), Positives = 296/574 (51%), Gaps = 95/574 (16%)

Query: 319  RIVNGKGEGP--PAKHPSLKPSTEMEDPAVKGAVQXKNVQTLR-AEQALPVASEEEQQRR 375
            RI  G   G   P   P+LK + E ++  +  A + K+VQT   AEQ L +ASE EQ+R 
Sbjct: 764  RITGGWKSGTEYPENLPTLKATIENKNSVLNTATKMKDVQTSTPAEQDLEMASEGEQKRL 823

Query: 376  ERSEKKQPQ-------------VIEGNNTYKSE--------------------------- 395
            E  E  QPQ             +I+ + T   +                           
Sbjct: 824  EEYENNQPQVKNQIHSRDDLDDIIQSSQTVSEDGDSLCCNCKNVILLIDQHEMKCKDCVH 883

Query: 396  --KI-----------QLSENICH----------STFSAAADRLTQQRKIGKTYPQQFPKK 432
              KI           +L +N C           +  S    RL+++ +I      +    
Sbjct: 884  LLKIKKTFCLCKRLTELKDNHCEQLRVKIRKLKNKASVLQKRLSEKEEIKSQLKHE---T 940

Query: 433  LKEEHDRCTLK----QENEEKTNVNMLHKKNREELERKEKQYKKEVEA-KQLEPTVQSLE 487
            L+ E + C+L+    QE +++ NV  LH+K RE+L   E+QY+ E +  K ++P ++S E
Sbjct: 941  LELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAE 1000

Query: 488  MKPKTARNTPNQDFHNHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKENKYLKDIK 547
            ++ KT  N  NQ     +E +DL+ EN +++ +IA LR E  T+KN NLEK  KYLKD +
Sbjct: 1001 VELKTGGNNSNQ-VSETDEKEDLLHENRLMQDEIARLRLEKDTIKNQNLEK--KYLKDFE 1057

Query: 548  IAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAENTRLNSELLKEKESKKKLEAEIE 607
            I K  +  L+K +K NEE + +T   Y  +L  L  ENT L S+L K++ES ++LE E++
Sbjct: 1058 IVKRKHEDLQKALKRNEETLAETIACYSGQLAALTDENTTLRSKLEKQRESGQRLETEMQ 1117

Query: 608  SYQSRLAAAISKHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKM 667
            SY+ RL AA+  H ++  ++R+ +LA + T D     K       +      L+ QLSK 
Sbjct: 1118 SYRCRLNAALCDHDQSHSSKRDQELAFQGTVD-----KCCHLQENLNSHVLILSLQLSKA 1172

Query: 668  QIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKW 727
            + KF  L+ +   T + L++K+L  E VQ++L Q Q Q+K++++MY+S    + K   K 
Sbjct: 1173 ESKFRVLETELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEK- 1231

Query: 728  NCVEERICQLQRENPWLEQQLVDVHQKEDHKE-IVINIQRGF--------IESRKKDLML 778
               +ER CQL+++N  L+QQL D   K D++E  ++NIQ            E RK  L+L
Sbjct: 1232 ---QERFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVENLQAECRKHRLLL 1288

Query: 779  EEKNKKLMNEYDHLKESLFQYERQKAETVVSIKE 812
            EE NK L+NE +H KE   QYE++KAE  V++++
Sbjct: 1289 EEDNKMLVNELNHSKEKKCQYEKEKAEREVAVRQ 1322


>gi|239747793 PREDICTED: protein immuno-reactive with anti-PTH
           polyclonal antibodies [Homo sapiens]
          Length = 868

 Score =  251 bits (641), Expect = 2e-66
 Identities = 190/574 (33%), Positives = 295/574 (51%), Gaps = 95/574 (16%)

Query: 319 RIVNGKGEGP--PAKHPSLKPSTEMEDPAVKGAVQXKNVQTLR-AEQALPVASEEEQQRR 375
           RI  G   G   P   P+LK + E ++  +  A + K+VQT   AEQ L +ASE EQ+R 
Sbjct: 202 RITGGWKSGTEYPENLPTLKATIENKNSVLNTATKMKDVQTSTPAEQDLEMASEGEQKRL 261

Query: 376 ERSEKKQPQ-------------VIEGNNTYKSE--------------------------- 395
           E  E  QPQ             +I+ + T   +                           
Sbjct: 262 EEYENNQPQVKNQIHSRDDLDDIIQSSQTVSEDGDSLCCNCKNVILLIDQHEMKCKDCVH 321

Query: 396 --KI-----------QLSENICH----------STFSAAADRLTQQRKIGKTYPQQFPKK 432
             KI           +L +N C           +  S    RL+++ +I      +    
Sbjct: 322 LLKIKKTFCLCKRLTELKDNHCEQLRVKIRKLKNKASVLQKRLSEKEEIKSQLKHE---T 378

Query: 433 LKEEHDRCTLK----QENEEKTNVNMLHKKNREELERKEKQYKKEVEA-KQLEPTVQSLE 487
           L+ E + C+L+    QE +++ NV  LH+K RE+L   E+QY+ E +  K ++P ++S E
Sbjct: 379 LELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAE 438

Query: 488 MKPKTARNTPNQDFHNHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKENKYLKDIK 547
           ++ KT  N  NQ     +E +DL+ EN +++ +IA LR E  T+KN NLEK  KYLKD +
Sbjct: 439 VELKTGGNNSNQ-VSETDEKEDLLHENRLMQDEIARLRLEKDTIKNQNLEK--KYLKDFE 495

Query: 548 IAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAENTRLNSELLKEKESKKKLEAEIE 607
           I K  +  L+K +K NEE + +T   Y  +L  L  ENT L S+L K++ES ++LE E++
Sbjct: 496 IVKRKHEDLQKALKRNEETLAETIACYSGQLAALTDENTTLRSKLEKQRESGQRLETEMQ 555

Query: 608 SYQSRLAAAISKHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKM 667
           SY+ RL AA+  H ++  ++R+ +LA + T D     K       +      L+ QLSK 
Sbjct: 556 SYRCRLNAALCDHDQSHSSKRDQELAFQGTVD-----KCCHLQENLNSHVLILSLQLSKA 610

Query: 668 QIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKW 727
           + KF  L+ +   T + L++K+L  E VQ++L Q Q Q+K++++MY+S    + K   K 
Sbjct: 611 ESKFRVLETELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEK- 669

Query: 728 NCVEERICQLQRENPWLEQQLVDVHQKEDHKE-IVINIQRGF--------IESRKKDLML 778
              +ER CQL+++N  L+QQL D   K D++E  ++NIQ            E RK  L+L
Sbjct: 670 ---QERFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVENLQAECRKHRLLL 726

Query: 779 EEKNKKLMNEYDHLKESLFQYERQKAETVVSIKE 812
           EE NK L+NE  H KE   QYE++KAE  V++++
Sbjct: 727 EEDNKMLVNELTHSKEKECQYEKEKAEREVAVRQ 760


>gi|239741684 PREDICTED: ankyrin repeat domain 36 [Homo sapiens]
          Length = 1524

 Score =  249 bits (637), Expect = 6e-66
 Identities = 187/574 (32%), Positives = 293/574 (51%), Gaps = 95/574 (16%)

Query: 319  RIVNGKGEGP--PAKHPSLKPSTEMEDPAVKGAVQXKNVQTLR-AEQALPVASEEEQQRR 375
            RI  G   G   P   P+LK + E ++  +  A + K+VQT   AEQ L +ASE EQ+R 
Sbjct: 858  RITGGWKSGTEYPENLPTLKATIENKNSVLNTATKMKDVQTSTPAEQDLEMASEGEQKRL 917

Query: 376  ERSEKKQPQV-------------IEGNNTYKSEK-------------------------- 396
            E  E  QPQV             I+ + T   +                           
Sbjct: 918  EEYENNQPQVKNQIHSRDDLDDIIQSSQTVSEDGDSLCCNCKNVILLIDQHEMKCKDCVH 977

Query: 397  --------------IQLSENICH----------STFSAAADRLTQQRKIGKTYPQQFPKK 432
                          I+L +N C           +  S    R++++ +I      +    
Sbjct: 978  LLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEI--- 1034

Query: 433  LKEEHDRCTLK----QENEEKTNVNMLHKKNREELERKEKQYKKEVEA-KQLEPTVQSLE 487
            L+ E + C+L+    QE +++ NV  +H+K RE+L   E+QY+ E +  K ++P ++S E
Sbjct: 1035 LELEKELCSLRFAIQQEKKKRRNVEEVHQKVREKLRITEEQYRIEADVTKPIKPALKSAE 1094

Query: 488  MKPKTARNTPNQDFHNHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKENKYLKDIK 547
            ++ KT  N  NQ     +E +DL+ EN +++ +IA LR E  T+KN NLEK  KYLKD +
Sbjct: 1095 VELKTGGNNSNQ-VSETDEKEDLLHENRLMQDEIARLRLEKDTIKNQNLEK--KYLKDFE 1151

Query: 548  IAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAENTRLNSELLKEKESKKKLEAEIE 607
            I K  +  L+K +K N E + KT   Y  +L  L  ENT L S+L K++ES+++LE E++
Sbjct: 1152 IVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQ 1211

Query: 608  SYQSRLAAAISKHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKM 667
            SY  RL AA   H ++  ++R+ +LA + T D    ++       +      L+ QLSK 
Sbjct: 1212 SYHCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQ-----ENLNSHVLILSLQLSKA 1266

Query: 668  QIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKW 727
            + K   LK +   T + L++K+L  E VQ++L Q Q Q+K++++MY+S    + K   K 
Sbjct: 1267 ESKSRVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEK- 1325

Query: 728  NCVEERICQLQRENPWLEQQLVDVHQKEDHKE-IVINIQRGF--------IESRKKDLML 778
               +ER CQL+++N  L+QQL D   K D++E  ++NIQ            E RK  L+L
Sbjct: 1326 ---QERFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLL 1382

Query: 779  EEKNKKLMNEYDHLKESLFQYERQKAETVVSIKE 812
            EE NK L+NE +H KE   QYE++KAE  V++++
Sbjct: 1383 EEDNKMLVNELNHSKEKECQYEKEKAEREVAVRQ 1416


>gi|124517695 ankyrin repeat domain 36B [Homo sapiens]
          Length = 1121

 Score =  249 bits (637), Expect = 6e-66
 Identities = 188/574 (32%), Positives = 292/574 (50%), Gaps = 95/574 (16%)

Query: 319  RIVNGKGEGP--PAKHPSLKPSTEMEDPAVKGAVQXKNVQTLR-AEQALPVASEEEQQRR 375
            RI  G   G   P    +LK + E +D  +  A + K VQT   AEQ L +ASE EQ+R 
Sbjct: 455  RITGGGKSGTEYPENLRTLKATIENKDSVLNTATKMKEVQTSTPAEQDLEMASEGEQKRL 514

Query: 376  ERSEKKQPQV-------------IEGNNTYKSEK-------------------------- 396
            E  E  QPQV             I+ + T   +                           
Sbjct: 515  EEYENNQPQVKNQIHSRDDLDDIIQSSQTVSEDGDSLCCNCKNVILLIDQHEMKCKDCVH 574

Query: 397  --------------IQLSENICH----------STFSAAADRLTQQRKIGKTYPQQFPKK 432
                          I+L +N C           +  S    R++++ +I      +    
Sbjct: 575  LLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEI--- 631

Query: 433  LKEEHDRCTLK----QENEEKTNVNMLHKKNREELERKEKQYKKEVEA-KQLEPTVQSLE 487
            L+ E + C+L+    QE +++ NV  LH+K RE+L   E+QY+ E +  K ++P ++S E
Sbjct: 632  LELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAE 691

Query: 488  MKPKTARNTPNQDFHNHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKENKYLKDIK 547
            ++ KT  N  NQ     +E +DL+ EN +++ +IA LR E  T+KN NLEK  KYLKD +
Sbjct: 692  VELKTGGNNSNQ-VSETDEKEDLLHENRLMQDEIARLRLEKDTIKNQNLEK--KYLKDFE 748

Query: 548  IAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAENTRLNSELLKEKESKKKLEAEIE 607
            I K  +  L+K +K N E + KT   Y  +L  L  ENT L S+L K++ES+++LE E++
Sbjct: 749  IVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQ 808

Query: 608  SYQSRLAAAISKHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKM 667
            SY+ RL AA   H ++  ++R+ +LA + T D    ++       +      L+ QLSK 
Sbjct: 809  SYRCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQ-----ENLNSHVLILSLQLSKA 863

Query: 668  QIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKW 727
            + K   LK +   T + L++K+L  E VQ++L Q Q Q+K++++MY+S    + K   K 
Sbjct: 864  ESKSRVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEK- 922

Query: 728  NCVEERICQLQRENPWLEQQLVDVHQKEDHKE-IVINIQRGF--------IESRKKDLML 778
               +ER CQL+++N  L+QQL D   K D++E  ++NIQ            E RK  L+L
Sbjct: 923  ---QERFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLL 979

Query: 779  EEKNKKLMNEYDHLKESLFQYERQKAETVVSIKE 812
            EE NK L+NE +H KE   QYE++KAE  V++++
Sbjct: 980  EEDNKMLVNELNHSKEKECQYEKEKAEREVAVRQ 1013


>gi|52856430 protein expressed in prostate, ovary, testis, and
           placenta 15 [Homo sapiens]
          Length = 581

 Score =  247 bits (631), Expect = 3e-65
 Identities = 175/554 (31%), Positives = 284/554 (51%), Gaps = 99/554 (17%)

Query: 19  DHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDLDALDKQHRTALHLACASG 78
           D  +    Y +R  +L K+H+AA  G     +  +  R  D++  DKQ RTALHLA A+G
Sbjct: 125 DSAFMEPRYHVRREDLDKLHRAAWWGKVPRKDLIVMLRDTDMNKRDKQKRTALHLASANG 184

Query: 79  HVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALH 138
           + +VV LL++R+CQ+++ D + RT LI+AV CQE+ C ++LLEHGA+ N++D YGNTALH
Sbjct: 185 NSEVVQLLLDRRCQLNVLDNKKRTALIKAVQCQEDECVLMLLEHGADGNIQDEYGNTALH 244

Query: 139 YAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEKMVEFLLKNKASTHAVDRL 198
           YA+Y+E   +A+ LL +G +IE+ +K   TPLL  +  +K+++V+FL+K KA+ +A+DR 
Sbjct: 245 YAIYNEDKLMAKALLLYGADIESKNKCGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRY 304

Query: 199 RXTALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAISCRLTKIQQQILEHKKMI 258
             TAL+LAV   S  IVN+LL+Q+++V +QD+ G+ A +YA+S                 
Sbjct: 305 GRTALILAVCCGSASIVNLLLEQNVDVSSQDLSGQTAREYAVS----------------- 347

Query: 259 LKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQCVPEKVSEPLRGPSHGKGN 318
                           S  H +C       + ++L ++++   PE+              
Sbjct: 348 ----------------SHHHVICELLSDYKEKQMLKISSENSNPEQ-------------- 377

Query: 319 RIVNGKGEGPPAKHPSLKPSTEMEDPAVKGAVQXKNVQTLRAEQALPVASEEEQQRRERS 378
                           LK ++E E   +K +   +N Q  +  Q   +  + +++  E  
Sbjct: 378 ---------------DLKLTSEEESQRLKVS---ENSQPEKMSQEPEINKDCDREVEEEI 419

Query: 379 EKKQPQVIEGNNTYKSEKIQLSENICHSTFSA-AADRLTQQRKIGKTYPQQFPKKLKEEH 437
           +K           + S  + L EN+ +   +    D L  QRK  K   QQFP    EE+
Sbjct: 420 KK-----------HGSNPVGLPENLTNGASAGNGDDGLIPQRKSRKPENQQFPDTENEEY 468

Query: 438 DRCTLKQENEEKTNVNMLHKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKPKTARNTP 497
                   +E+      L ++    + + E    K+   KQ+E  V   EM  K +    
Sbjct: 469 ------HSDEQNDTQKQLSEEQNTGISQDEILTNKQ---KQIE--VAEKEMNSKLSL--- 514

Query: 498 NQDFHNHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKENKYLKDIKIAKETNAALE 557
                +H++ +DL+ EN +L+ +IA+LR E+   K+ N  +ENK L++I+  KE    L 
Sbjct: 515 -----SHKKEEDLLRENSMLREEIAMLRLELDETKHQNQLRENKILEEIESVKE---KLL 566

Query: 558 KCIKLNEEMITKTA 571
           K I+LNEE +TKT+
Sbjct: 567 KAIQLNEEALTKTS 580


>gi|169163827 PREDICTED: similar to UPF0634 protein KIAA1641 [Homo
           sapiens]
          Length = 475

 Score =  245 bits (626), Expect = 1e-64
 Identities = 155/403 (38%), Positives = 238/403 (59%), Gaps = 26/403 (6%)

Query: 433 LKEEHDRCTLK----QENEEKTNVNMLHKKNREELERKEKQYKKEVEA-KQLEPTVQSLE 487
           L+ E + C+L+    QE +++ NV  LH+K RE+L   E+QY+ E +  K ++P ++S E
Sbjct: 85  LELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAE 144

Query: 488 MKPKTARNTPNQDFHNHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKENKYLKDIK 547
           ++ KT  N  NQ     +E +DL+ EN +++ +IA LR +  T+KN NLEK  KYLKD +
Sbjct: 145 VELKTGGNNSNQ-VSETDEKEDLLHENRLMQDEIARLRLDTDTIKNQNLEK--KYLKDFE 201

Query: 548 IAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAENTRLNSELLKEKESKKKLEAEIE 607
           I K  +  L+K +K N E + KT   Y  +L  L  ENT L S+L K++ES+++LE E++
Sbjct: 202 IVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQ 261

Query: 608 SYQSRLAAAISKHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKM 667
           SY  RL AA   H ++  ++R+ +LA + T D    ++       +      L+ QLSK 
Sbjct: 262 SYHCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQ-----ENLNSHVLILSLQLSKA 316

Query: 668 QIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKW 727
           + K   LK +   T + L++K+L  E VQ++L Q Q Q+K++++MY+S    + K   K 
Sbjct: 317 ESKSRVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEK- 375

Query: 728 NCVEERICQLQRENPWLEQQLVDVHQKEDHKE-IVINIQRGF--------IESRKKDLML 778
              +ER CQL+++N  L+QQL D   K D++E  ++NIQ            E RK  L+L
Sbjct: 376 ---QERFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLL 432

Query: 779 EEKNKKLMNEYDHLKESLFQYERQKAETVVSIKEDKYFQTSRK 821
           EE NK L+NE +H KE   QYE++KAE  VSIK++KYF    K
Sbjct: 433 EEDNKMLVNELNHSKEKECQYEKEKAEREVSIKKNKYFSNFLK 475


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.128    0.351 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,683,649
Number of Sequences: 37866
Number of extensions: 1323236
Number of successful extensions: 14648
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 509
Number of HSP's successfully gapped in prelim test: 983
Number of HSP's that attempted gapping in prelim test: 6543
Number of HSP's gapped (non-prelim): 5099
length of query: 823
length of database: 18,247,518
effective HSP length: 111
effective length of query: 712
effective length of database: 14,044,392
effective search space: 9999607104
effective search space used: 9999607104
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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