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Search of human proteins with 22758136
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22758136 MAP7 domain containing 2 [Homo sapiens]
(732 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22758136 MAP7 domain containing 2 [Homo sapiens] 1441 0.0
gi|4505101 microtubule-associated protein 7 [Homo sapiens] 279 8e-75
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 204 2e-52
gi|147903302 MAP7 domain containing 3 [Homo sapiens] 107 3e-23
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 98 2e-20
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 98 2e-20
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 98 2e-20
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 98 2e-20
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 92 2e-18
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 89 1e-17
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 89 1e-17
gi|148746195 trichohyalin [Homo sapiens] 89 1e-17
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 87 4e-17
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 84 5e-16
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 84 5e-16
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 83 1e-15
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 82 1e-15
gi|221219020 NYD-SP11 protein [Homo sapiens] 82 2e-15
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 81 3e-15
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 81 3e-15
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 81 3e-15
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 81 3e-15
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 81 4e-15
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 80 5e-15
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 80 5e-15
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 80 9e-15
gi|239752551 PREDICTED: hypothetical protein [Homo sapiens] 80 9e-15
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 80 9e-15
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 79 1e-14
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 79 1e-14
>gi|22758136 MAP7 domain containing 2 [Homo sapiens]
Length = 732
Score = 1441 bits (3730), Expect = 0.0
Identities = 732/732 (100%), Positives = 732/732 (100%)
Query: 1 MERGGGGSGTGSRPEGTARGTSLPGKIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKE 60
MERGGGGSGTGSRPEGTARGTSLPGKIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKE
Sbjct: 1 MERGGGGSGTGSRPEGTARGTSLPGKIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKE 60
Query: 61 RREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKL 120
RREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKL
Sbjct: 61 RREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKL 120
Query: 121 REEEERLEAMMRRSLERTQQLELKKKYSWGAPLAIGPGGHDACDKLSTSTMSLPKPTEPP 180
REEEERLEAMMRRSLERTQQLELKKKYSWGAPLAIGPGGHDACDKLSTSTMSLPKPTEPP
Sbjct: 121 REEEERLEAMMRRSLERTQQLELKKKYSWGAPLAIGPGGHDACDKLSTSTMSLPKPTEPP 180
Query: 181 MNKRLSSSTVAISYSPDRVFHVCPRLAPLGPLNPSYKSSPTRNIEKKKATSTSTSGAGDV 240
MNKRLSSSTVAISYSPDRVFHVCPRLAPLGPLNPSYKSSPTRNIEKKKATSTSTSGAGDV
Sbjct: 181 MNKRLSSSTVAISYSPDRVFHVCPRLAPLGPLNPSYKSSPTRNIEKKKATSTSTSGAGDV 240
Query: 241 GKEALSGGEASLVEKVKRGQRTATSLPVVNFGSPLRRCEFSGGIPKRPSSPVISKTATKA 300
GKEALSGGEASLVEKVKRGQRTATSLPVVNFGSPLRRCEFSGGIPKRPSSPVISKTATKA
Sbjct: 241 GKEALSGGEASLVEKVKRGQRTATSLPVVNFGSPLRRCEFSGGIPKRPSSPVISKTATKA 300
Query: 301 YPQSPKTTKPPYPGSPVKYRLPALSGQDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEAL 360
YPQSPKTTKPPYPGSPVKYRLPALSGQDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEAL
Sbjct: 301 YPQSPKTTKPPYPGSPVKYRLPALSGQDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEAL 360
Query: 361 EKHVVDKHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQ 420
EKHVVDKHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQ
Sbjct: 361 EKHVVDKHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQ 420
Query: 421 ERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEA 480
ERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEA
Sbjct: 421 ERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEA 480
Query: 481 KRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLER 540
KRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLER
Sbjct: 481 KRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLER 540
Query: 541 KKRIDEIMKRTRKSDVPPQVKKEDPKVGVQPAVCVEKKTKLVVPNKMEINGLNTCQEVNG 600
KKRIDEIMKRTRKSDVPPQVKKEDPKVGVQPAVCVEKKTKLVVPNKMEINGLNTCQEVNG
Sbjct: 541 KKRIDEIMKRTRKSDVPPQVKKEDPKVGVQPAVCVEKKTKLVVPNKMEINGLNTCQEVNG 600
Query: 601 VDHAAPETYPQDIFSNGLKPAGGLIHLDALDGKSNSLDDSTEEVQSMDVSPVSKEELISI 660
VDHAAPETYPQDIFSNGLKPAGGLIHLDALDGKSNSLDDSTEEVQSMDVSPVSKEELISI
Sbjct: 601 VDHAAPETYPQDIFSNGLKPAGGLIHLDALDGKSNSLDDSTEEVQSMDVSPVSKEELISI 660
Query: 661 PEFSPVSEMIPGVSLDQNGTGNARALQDLLDFTGPPTFPKRSSENLSLDDCNKNLIEGFN 720
PEFSPVSEMIPGVSLDQNGTGNARALQDLLDFTGPPTFPKRSSENLSLDDCNKNLIEGFN
Sbjct: 661 PEFSPVSEMIPGVSLDQNGTGNARALQDLLDFTGPPTFPKRSSENLSLDDCNKNLIEGFN 720
Query: 721 SPGQETPLNTFC 732
SPGQETPLNTFC
Sbjct: 721 SPGQETPLNTFC 732
>gi|4505101 microtubule-associated protein 7 [Homo sapiens]
Length = 749
Score = 279 bits (713), Expect = 8e-75
Identities = 216/590 (36%), Positives = 317/590 (53%), Gaps = 94/590 (15%)
Query: 49 LKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQK 108
L+ D+RQRLA+ERREEREK LAARE LE+++RAR YEK +EER ++LEEQRQ+E+++
Sbjct: 61 LRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERR 120
Query: 109 RAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELK-KKYSWGAPLAIGPGGHDAC-DKL 166
RAAVEEKR+Q+L E++ER EA++RR++ER+Q+ + K ++SWG L P H A D+
Sbjct: 121 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRR 180
Query: 167 STSTMSLPKPTEPPMNKRLSSSTVAISYSPDRVFH---------VCPRL----------- 206
S STM+L K +P ++KRLSSS+ + SPDR V RL
Sbjct: 181 SVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARS 240
Query: 207 ----------APLGPLNPSYKSSPTRN-IEKKKATSTSTSGAGDVGKEALSGGEASLVEK 255
A P+ YK++ +RN +++ K T G+ + + G AS ++
Sbjct: 241 KSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSS---RRRIIHGTASYKKE 297
Query: 256 VKR--------GQRTATSLPVVNFGSPLRRCEF--SGGIPKRPSSP-VISKTATKAYPQS 304
+R G R A S P R + S +P P +P S + +
Sbjct: 298 RERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAA 357
Query: 305 PKTTKPPYPGS--PVKYRLPALSGQDMPKRKAEK---EKSNKER------------EGTL 347
P +PP PG+ PVK + + P+++ +K E S K R E T
Sbjct: 358 PAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTP 417
Query: 348 AQQAAGPQGEEALEKHVVDKHASEKHAAA---------AGGKAENSAALGKPTAGTTDAG 398
A+ GP + A A A N++A K +AGTTD
Sbjct: 418 AEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPE 477
Query: 399 EAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEER 458
EA ++LAEKRR AR Q+E+EE+ER E+EE +R +REEL ++ EER
Sbjct: 478 EATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEER-------------T 524
Query: 459 KRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREV 518
R+EEE ++ E E+ R+ E+ +R+AEE L +E+E+ E+A +K++EA + RE
Sbjct: 525 TRREEESRRLEAEQAREKEEQLQRQAEERAL----REREEAERAQRQKEEEA---RVREE 577
Query: 519 AEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKEDPKVG 568
AE++R ERE+ + EQERLERKKR++EIMKRTR+++ + K D + G
Sbjct: 578 AERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDK-KTSDQRNG 626
Score = 53.5 bits (127), Expect = 7e-07
Identities = 49/167 (29%), Positives = 77/167 (46%), Gaps = 35/167 (20%)
Query: 8 SGTGSRPEGTARGTSLPGKIAEPGA-VRTSQPNYRPQGMEGFLKSDERQRLAKERR--EE 64
S P T S P A V+TS P+ L E++RLA+E+R EE
Sbjct: 441 SAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLA--EKRRLAREQREKEE 498
Query: 65 REKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQ----------------------- 101
RE+ REQ+ LE+QKR L ++ EER + EE+
Sbjct: 499 RER----REQEELERQKREELA-QRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEER 553
Query: 102 --RQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
R+RE+ +RA +++ + ++REE ER+ + +R +Q L++K
Sbjct: 554 ALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERK 600
Score = 48.1 bits (113), Expect = 3e-05
Identities = 39/125 (31%), Positives = 66/125 (52%), Gaps = 11/125 (8%)
Query: 367 KHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKE 426
K+AS + A+A G+ N + KP + + LA +RR+ R +K+ +E V E
Sbjct: 33 KNASSRPASAISGQNNNHSG-NKPDPPPVLRVDDRQRLARERREER-EKQLAAREIVWLE 90
Query: 427 EQDRLEREELKRKAEEERLRLEEEARKQE------EERKRQ--EEEKKKQEGEEKRKAGE 478
++R R+ ++ EE + RLEE+ +K+E EE++RQ EE+K++ E +R
Sbjct: 91 REERA-RQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMER 149
Query: 479 EAKRK 483
K K
Sbjct: 150 SQKPK 154
Score = 47.8 bits (112), Expect = 4e-05
Identities = 51/201 (25%), Positives = 87/201 (43%), Gaps = 18/201 (8%)
Query: 14 PEGTARGTSLPGKIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKE---RREEREKCLA 70
PE R + ++A + + + +E + + QR+A+E RREE + L
Sbjct: 476 PEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLE 535
Query: 71 AREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVE------EKRKQKLREEE 124
A + + E+Q + + + E+ + ER QRQ+E++ R E E+ K REE+
Sbjct: 536 AEQAREKEEQLQRQAE-ERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQ 594
Query: 125 ERLEAMMR--RSLERTQQLELKKKYSWG------APLAIGPGGHDACDKLSTSTMSLPKP 176
ERLE R ++RT++ E K + A A+ G + +T+ KP
Sbjct: 595 ERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKP 654
Query: 177 TEPPMNKRLSSSTVAISYSPD 197
P S V + +PD
Sbjct: 655 VGSPHVVTSHQSKVTVESTPD 675
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 204 bits (520), Expect = 2e-52
Identities = 201/690 (29%), Positives = 308/690 (44%), Gaps = 175/690 (25%)
Query: 3 RGGGGSGTGSRPEGTARGTSLPGKIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERR 62
RG G R R +S P A P + P + K+ ER +LAKERR
Sbjct: 94 RGPTPPAMGPRDARPPRRSSQPSPTAVPASDS-------PPTKQEVKKAGERHKLAKERR 146
Query: 63 EEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKLRE 122
EER K LAA++ LEK+++A+ EKQ++ER R+LEEQR + +Q+RAA+EE+++QKL +
Sbjct: 147 EERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEK 206
Query: 123 E----EERLEAMMRRSLERTQQLE-----------------------------------L 143
E ++ ++++ +Q +
Sbjct: 207 NKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHSSPGHKTSGSRCSVSAVNLPKHVDSII 266
Query: 144 KKKYS------WGAP-----LAIGPGGHDACDKLSTSTMS----------LPK------- 175
K+ S W +P L + D+L T T+S LP+
Sbjct: 267 NKRLSKSSATLWNSPSRNRSLQLSAWESSIVDRLMTPTLSFLARSRSAVTLPRNGRDQGR 326
Query: 176 ---PTEPPMNKRLSSSTVAISYSPDRVFH-----VCPRLAPLGPLNPSYKSSPTRNIEKK 227
P P R +S +A PDR VCPR A PL P S TR++ +
Sbjct: 327 GCDPGRGPTWGRAGAS-LARGPQPDRTHPSAAVPVCPRSASASPLTPC---SVTRSVHR- 381
Query: 228 KATSTSTSGAGDVG--KEALSGG---------EASLVEKVKRGQRTATSLPVVNFGSPLR 276
+ AG+ G ++ +GG EAS V+K ++ + + + + R
Sbjct: 382 ------CAPAGERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARER 435
Query: 277 RCEFSGGIPKRPSSPVISKTAT------KAYPQSPKTT----KPPYPGSPVKYRLPALSG 326
+ +P P + + + TA+ KA P SP T+ P P + LP
Sbjct: 436 SLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPP 495
Query: 327 QDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAEN--- 383
+ K + ++ E + AAGP+ + ++ ++ S A+ A A +
Sbjct: 496 SPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTP 555
Query: 384 ---------------SAAL------------GKPTAGTTDAGEAAKILAEKRRQARLQKE 416
+A L KP AGTTD EA ++LAEKRRQAR Q+
Sbjct: 556 APPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQR- 614
Query: 417 QEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKA 476
E+EEQ+R RL+ E + R +EE+ R+ E + ++E E +R+
Sbjct: 615 -------EREEQER-------------RLQAERDKRMREEQLAREAEARAEREAEARRRE 654
Query: 477 GEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQE 536
+EA+ KA+ E QE+QE+ ++KQKE AE ++RE AE+ RLERE+ Q EQE
Sbjct: 655 EQEAREKAQAE--------QEEQER--LQKQKEEAEARSREEAERQRLEREKHFQQQEQE 704
Query: 537 RLERKKRIDEIMKRTRKSDVPPQVKKEDPK 566
R ER+KR++EIMKRTRKS+V +K+D K
Sbjct: 705 RQERRKRLEEIMKRTRKSEVSETKQKQDSK 734
Score = 45.1 bits (105), Expect = 2e-04
Identities = 51/185 (27%), Positives = 73/185 (39%), Gaps = 18/185 (9%)
Query: 288 PSSPVISKTATKAY-----PQSPKTTKPPYPGSPVKYRLPALSGQDMPKRKAEKEKSNKE 342
P +P K AT + P+SP P P P + + + P A + +
Sbjct: 49 PDTPPAMKNATSSKQLPLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARP 108
Query: 343 -REGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAA 401
R + A P + K V K A E+H A + E + L A + E A
Sbjct: 109 PRRSSQPSPTAVPASDSPPTKQEVKK-AGERHKLAKERREERAKYLAAKKAVWLEKEEKA 167
Query: 402 KILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQ 461
K L EK + QER + E+ RL+ E+ +R A EER R + E K+ E Q
Sbjct: 168 KALREK----------QLQERRRRLEEQRLKAEQ-RRAALEERQRQKLEKNKERYEAAIQ 216
Query: 462 EEEKK 466
KK
Sbjct: 217 RSVKK 221
Score = 42.0 bits (97), Expect = 0.002
Identities = 24/111 (21%), Positives = 57/111 (51%), Gaps = 13/111 (11%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLE---------- 99
+ +E++RL K++ E + E+Q LE++K + Q E++ +ER ++LE
Sbjct: 665 EQEEQERLQKQKEEAEARSREEAERQRLEREKHFQ-QQEQERQERRKRLEEIMKRTRKSE 723
Query: 100 --EQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYS 148
E +Q++D K A + ++ E R + + ++++ + + + ++S
Sbjct: 724 VSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQWS 774
Score = 40.0 bits (92), Expect = 0.008
Identities = 48/250 (19%), Positives = 94/250 (37%), Gaps = 25/250 (10%)
Query: 277 RCEFSGGIPKRPSSPVISKTATKAYPQSPKTTKPPYPGSPVKYRLPALSGQDMPKRKAEK 336
R E G P V+++T + P PP P P+ +P P K
Sbjct: 6 RAELGAGAPPA----VVARTPPEPRPSPEGDPSPPPP--PMSALVPDTPPDTPPAMK--- 56
Query: 337 EKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTAGTTD 396
N L + P G+ + + A + G P G D
Sbjct: 57 ---NATSSKQLPLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTP--------PAMGPRD 105
Query: 397 AGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEE 456
A + ++ V+K ER +L ++ EER + +
Sbjct: 106 ARPPRRSSQPSPTAVPASDSPPTKQEVKKAG----ERHKLAKERREERAKYLAAKKAVWL 161
Query: 457 ERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAR 516
E++ + + ++++ +E+R+ EE + KAE+ E+++++K EK E+ + A + +
Sbjct: 162 EKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNK-ERYEAAIQRSVK 220
Query: 517 EVAEQMRLER 526
+ ++R +R
Sbjct: 221 KTWAEIRQQR 230
Score = 35.8 bits (81), Expect = 0.15
Identities = 27/92 (29%), Positives = 47/92 (51%), Gaps = 15/92 (16%)
Query: 53 ERQRLAKERREEREKCLAAREQQI-LEKQK------------RARLQYEKQMEERWRKLE 99
E + +E +E REK A +E+Q L+KQK R RL+ EK +++ ++ +
Sbjct: 647 EAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQ 706
Query: 100 EQRQR--EDQKRAAVEEKRKQKLREEEERLEA 129
E+R+R E KR E + K +++ + A
Sbjct: 707 ERRKRLEEIMKRTRKSEVSETKQKQDSKEANA 738
>gi|147903302 MAP7 domain containing 3 [Homo sapiens]
Length = 876
Score = 107 bits (268), Expect = 3e-23
Identities = 73/194 (37%), Positives = 111/194 (57%), Gaps = 18/194 (9%)
Query: 1 MERGGGGSGTGSRP---EGTARGTSLPGKIAEP-------GAVRTSQPN----YRPQGME 46
M G +G G P E AR + +IA+ V T N ++P
Sbjct: 1 MMADGAAAGAGGSPSLRELRARMVAAANEIAKERRKQDVVNRVATHSSNIRSTFKPVIDG 60
Query: 47 GFLKSDERQRLAKERREEREKCLAA-REQQILEKQKRARLQYEKQMEERWRKLEEQRQRE 105
LK+D +QRLA+ERREE+ + A +E Q+LEK+++ +LQYEKQMEER RKL+E++++E
Sbjct: 61 SMLKNDIKQRLARERREEKRRQQDANKETQLLEKERKTKLQYEKQMEERQRKLKERKEKE 120
Query: 106 DQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLE--LKKKYSWGAPLAIGPGGHDAC 163
+Q+R A EEKR QK ++E+ A++ R+LER + + +K++SWG A+
Sbjct: 121 EQRRIAAEEKRHQKDEAQKEKFTAILYRTLERRRLADDYQQKRWSWGGS-AMANSESKTA 179
Query: 164 DKLSTSTMSLPKPT 177
+K S ST L + T
Sbjct: 180 NKRSASTEKLEQGT 193
Score = 95.9 bits (237), Expect = 1e-19
Identities = 88/266 (33%), Positives = 129/266 (48%), Gaps = 65/266 (24%)
Query: 291 PVISKTATKAYPQSPKTTKPPYPGSPVKYRLPALSGQDMPKRKAEKEKSNKEREGTLAQQ 350
P+ISK QSP+T+ P Y P+++ L S K+K E R L+Q
Sbjct: 527 PLISK-------QSPQTSFP-YKIMPIQHTLSVQSASSTVKKKKETVSKTTNRCEALSQ- 577
Query: 351 AAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQ 410
+H++ + + K TAG +A A KIL E RR
Sbjct: 578 -----------RHMIYEESGNKS-----------------TAGIMNAEAATKILTELRRL 609
Query: 411 ARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEG 470
AR Q+ EKEE EE +R+ ++R+ + + +E + E+ K ++G
Sbjct: 610 AREQR--------EKEE------EERQREEMQQRVIKKSKDMAKEAVGGQAEDHLKLKDG 655
Query: 471 EEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIM 530
+++ E K+K K +QE QE + QK A+ KA+E A++ + E E+IM
Sbjct: 656 QQQN----ETKKK-------KGWLDQEDQEAPL---QKGDAKIKAQEEADKRKKEHERIM 701
Query: 531 LQIEQERLERKKRIDEIMKRTRKSDV 556
LQ QERLERKKRI+EIMKRTRK+DV
Sbjct: 702 LQNLQERLERKKRIEEIMKRTRKTDV 727
Score = 49.3 bits (116), Expect = 1e-05
Identities = 76/317 (23%), Positives = 130/317 (41%), Gaps = 65/317 (20%)
Query: 406 EKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEK 465
EKRRQ Q +E + +EKE + +L+ E K EER R +E +++EE+R+ EEK
Sbjct: 78 EKRRQ---QDANKETQLLEKERKTKLQYE----KQMEERQRKLKERKEKEEQRRIAAEEK 130
Query: 466 KKQEGE--------------EKRKAGEEAKRK-----------AEEELLLKEKQEQEKQE 500
+ Q+ E E+R+ ++ ++K +E + K EK E
Sbjct: 131 RHQKDEAQKEKFTAILYRTLERRRLADDYQQKRWSWGGSAMANSESKTANKRSASTEKLE 190
Query: 501 K---AMIEK--------QKEAAETKA-REVAEQMRLEREQIMLQIEQERLERKKRIDEIM 548
+ A+I + Q A+ K +E + + + ++E+ ERK R+ +
Sbjct: 191 QGTSALIRQMPLSSAGLQNSVAKRKTDKERSSSLNRRDSNLHSSTDKEQAERKPRVTGVT 250
Query: 549 KRTRKSDVPPQVKKEDPKVGVQPAVCVEKKTKLVVP-NKMEINGLNTCQEVNGVDHAAPE 607
+ P K ++ AV T + P K+E + L + AP
Sbjct: 251 NYVMQYVTVPLRKCTSDEL---RAVMFPMSTMKIPPQTKVEESPLEKVETPPKASVDAPP 307
Query: 608 TYPQDIFSN---GLKPAGGLIHLDALDGKSNSLDDSTEEVQSMDVSPV-----SKEELIS 659
++F N P G+ G + + + V S+DVSPV S+ + +
Sbjct: 308 QVNVEVFCNTSMEASPKAGV-------GMAPEVSTDSFPVVSVDVSPVVSTYDSEMSMDA 360
Query: 660 IPEFSPVSEMIPGVSLD 676
PE S E +P V L+
Sbjct: 361 SPELS--IEALPKVDLE 375
Score = 46.2 bits (108), Expect = 1e-04
Identities = 43/166 (25%), Positives = 74/166 (44%), Gaps = 11/166 (6%)
Query: 374 AAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLER 433
AA AGG + A A E AK E+R+Q + + + + ++
Sbjct: 7 AAGAGGSPSLRELRARMVAA---ANEIAK---ERRKQDVVNRVATHSSNIRSTFKPVIDG 60
Query: 434 EELKRKAEEE--RLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLK 491
LK ++ R R EE+ R+Q+ ++ Q EK+++ + K EE +RK +E K
Sbjct: 61 SMLKNDIKQRLARERREEKRRQQDANKETQLLEKERKTKLQYEKQMEERQRKLKER---K 117
Query: 492 EKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQER 537
EK+EQ + QK+ A+ + LER ++ +Q+R
Sbjct: 118 EKEEQRRIAAEEKRHQKDEAQKEKFTAILYRTLERRRLADDYQQKR 163
Score = 35.4 bits (80), Expect = 0.19
Identities = 32/113 (28%), Positives = 53/113 (46%), Gaps = 24/113 (21%)
Query: 53 ERQRLAKERR--EEREKCLAAREQQILEKQ------------------KRARLQYEKQME 92
E +RLA+E+R EE E+ +Q++++K K + Q E + +
Sbjct: 605 ELRRLAREQREKEEEERQREEMQQRVIKKSKDMAKEAVGGQAEDHLKLKDGQQQNETKKK 664
Query: 93 ERWRKLEEQR---QREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLE 142
+ W E+Q Q+ D K A EE K+K E L+ + R LER +++E
Sbjct: 665 KGWLDQEDQEAPLQKGDAKIKAQEEADKRKKEHERIMLQNLQER-LERKKRIE 716
Score = 30.0 bits (66), Expect = 8.0
Identities = 24/74 (32%), Positives = 37/74 (50%), Gaps = 9/74 (12%)
Query: 76 ILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSL 135
+ E ++ AR Q EK+ EER R EE +QR +K + ++ E+ +L+
Sbjct: 603 LTELRRLAREQREKEEEERQR--EEMQQRVIKKSKDMAKEAVGGQAEDHLKLK------- 653
Query: 136 ERTQQLELKKKYSW 149
+ QQ E KKK W
Sbjct: 654 DGQQQNETKKKKGW 667
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 98.2 bits (243), Expect = 2e-20
Identities = 63/166 (37%), Positives = 105/166 (63%), Gaps = 14/166 (8%)
Query: 396 DAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEA---R 452
+ +AAK L ++RR+A ++ ++EE+ER +EE R + E L+R+ EEER R EEE R
Sbjct: 724 EKAKAAK-LEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARR 782
Query: 453 KQEEERKRQEEEK---KKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKE 509
KQEE +RQ E++ ++Q EE+R+ EEA R+ EE +E++E+ KQE+ + ++++E
Sbjct: 783 KQEEALRRQREQEIALRRQREEEERQQQEEALRRLEER--RREEEERRKQEELLRKQEEE 840
Query: 510 AAETKAREVAEQMRLEREQIMLQIEQERL-----ERKKRIDEIMKR 550
AA+ E Q RLE ++ ++ E RL ERK++ E+ ++
Sbjct: 841 AAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQ 886
Score = 82.0 bits (201), Expect = 2e-15
Identities = 52/158 (32%), Positives = 98/158 (62%), Gaps = 10/158 (6%)
Query: 414 QKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEE--RKRQEEEKKKQEGE 471
Q +Q E+ + K EQ+R E E ++ EEER R +EE R+Q+EE R++QEEE+K++E E
Sbjct: 719 QLQQLEKAKAAKLEQERREAEMRAKREEEERKR-QEELRRQQEEILRRQQEEERKRREEE 777
Query: 472 E--KRKAGEEAKRKAEEELLL---KEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLER 526
E +RK E +R+ E+E+ L +E++E+++QE+A+ ++ E + R E++ ++
Sbjct: 778 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQ 837
Query: 527 EQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKED 564
E+ + +E E ++R++E R R + +++ E+
Sbjct: 838 EEEAAKWAREEEEAQRRLEE--NRLRMEEEAARLRHEE 873
Score = 80.9 bits (198), Expect = 4e-15
Identities = 53/153 (34%), Positives = 93/153 (60%), Gaps = 8/153 (5%)
Query: 402 KILAEKRRQARLQKEQEEQERVEKEEQDRLEREE---LKRKAEEERLRLEEEARKQEEER 458
+IL ++ + R ++E+EE R ++EE R +RE+ L+R+ EEE + +EEA ++ EER
Sbjct: 761 EILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEER 820
Query: 459 KRQEEEKKKQEGEEKRKAGEEAKRKAEEE----LLLKEKQEQEKQEKAMIEKQKEAAETK 514
+R+EEE++KQE E RK EEA + A EE L+E + + ++E A + ++E + K
Sbjct: 821 RREEEERRKQE-ELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRK 879
Query: 515 AREVAEQMRLEREQIMLQIEQERLERKKRIDEI 547
EV Q L R++ Q RL+++++ ++
Sbjct: 880 ELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL 912
Score = 78.2 bits (191), Expect = 3e-14
Identities = 54/169 (31%), Positives = 97/169 (57%), Gaps = 10/169 (5%)
Query: 399 EAAKILAEKRRQA----RLQKEQEEQERVEKEEQDRLEREELKRKAEEE---RLRLEEEA 451
E K E RRQ R Q+E+E + R E+E R + E L+R+ E+E R + EEE
Sbjct: 747 EERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEE 806
Query: 452 RKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAA 511
R+Q+EE R+ EE++++ EE+R+ EE RK EEE K +E+E+ ++ + E +
Sbjct: 807 RQQQEEALRRLEERRRE--EEERRKQEELLRKQEEE-AAKWAREEEEAQRRLEENRLRME 863
Query: 512 ETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQV 560
E AR E+ +R+++ +Q ++E + ++++ E ++R ++ Q+
Sbjct: 864 EEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL 912
Score = 69.7 bits (169), Expect = 9e-12
Identities = 61/244 (25%), Positives = 114/244 (46%), Gaps = 43/244 (17%)
Query: 305 PKTTKPPYPGSPVKYRLPALSGQDMPKRKAEKE-KSNKEREGTLAQQAAGPQGEEALEKH 363
P T P P +L + + + E E ++ +E E Q+ Q EE L +
Sbjct: 707 PLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQ 766
Query: 364 VVDKHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERV 423
++ + A K E + + ++ ++ L++++EE+ER
Sbjct: 767 QEEERKRREEEELARRKQEEA------------------LRRQREQEIALRRQREEEERQ 808
Query: 424 EKEEQ-DRLE---REELKRKAEEERLRLEEE-----ARKQEEERKRQEEEKKKQEGEEKR 474
++EE RLE REE +R+ +EE LR +EE AR++EE ++R EE + + E
Sbjct: 809 QQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRME----- 863
Query: 475 KAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIE 534
EEA R L+ ++E+ K+++ +++QKE + ++ RL+++Q Q+
Sbjct: 864 ---EEAAR-------LRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLA 913
Query: 535 QERL 538
Q +L
Sbjct: 914 QMKL 917
Score = 65.1 bits (157), Expect = 2e-10
Identities = 41/134 (30%), Positives = 82/134 (61%), Gaps = 5/134 (3%)
Query: 434 EELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEK 493
E+L++ + + +LE+E R+ E KR+EEE+K+QE E +R+ E +R+ EEE +E+
Sbjct: 718 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQE-ELRRQQEEILRRQQEEERKRREE 776
Query: 494 QE--QEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERL-ERKKRIDEIMKR 550
+E + KQE+A + +Q+E R+ E+ R ++E+ + ++E+ R E ++R E + R
Sbjct: 777 EELARRKQEEA-LRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 835
Query: 551 TRKSDVPPQVKKED 564
++ + ++E+
Sbjct: 836 KQEEEAAKWAREEE 849
Score = 55.8 bits (133), Expect = 1e-07
Identities = 64/275 (23%), Positives = 116/275 (42%), Gaps = 74/275 (26%)
Query: 328 DMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAAL 387
+M ++ E+E+ +E ++ Q EE ++ ++ A K A + E AL
Sbjct: 739 EMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIAL 798
Query: 388 GKPTAGTT--DAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRL--EREELKRKAEEE 443
+ EA + L E+RR+ +++QEE R ++EE + E EE +R+ EE
Sbjct: 799 RRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEEN 858
Query: 444 RLRLEEEA---RKQEEE---------------RKRQEEEK-------------------- 465
RLR+EEEA R +EEE R+RQ++++
Sbjct: 859 RLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLP 918
Query: 466 -------------------------KKQEGEEKRKAGEEAKRKAEE--ELLLKEKQEQEK 498
+K E E +R+ EE +R+ E + L +++Q+Q++
Sbjct: 919 SSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQ 978
Query: 499 QEKAMIEKQKEAAETKA-----REVAEQMRLEREQ 528
+ K + TK+ +E A QM+ +++Q
Sbjct: 979 KLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQ 1013
Score = 52.4 bits (124), Expect = 2e-06
Identities = 33/113 (29%), Positives = 64/113 (56%), Gaps = 20/113 (17%)
Query: 55 QRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAV-- 112
+RL + RREE E+ +++++L KQ+ ++ ++ EE R+LEE R R +++ A +
Sbjct: 815 RRLEERRREEEER---RKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRH 871
Query: 113 -EEKRKQK----------LREEEERLEAMMRRSLERTQ----QLELKKKYSWG 150
EE+RK+K +R+ +++ EA+ R ++ Q Q++L +WG
Sbjct: 872 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 924
Score = 48.1 bits (113), Expect = 3e-05
Identities = 35/119 (29%), Positives = 62/119 (52%), Gaps = 4/119 (3%)
Query: 28 AEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQ-ILEKQKRARLQ 86
AE A R + R + + + R++ +ER+ E+ LA R+Q+ L +Q+ +
Sbjct: 738 AEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIA 797
Query: 87 YEKQMEERWRKLEEQRQRE-DQKRAAVEEKRKQK--LREEEERLEAMMRRSLERTQQLE 142
+Q EE R+ +E+ R +++R EE+RKQ+ LR++EE R E ++LE
Sbjct: 798 LRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLE 856
Score = 47.4 bits (111), Expect = 5e-05
Identities = 30/106 (28%), Positives = 59/106 (55%), Gaps = 8/106 (7%)
Query: 49 LKSDERQRLAKERREEREKC----LAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQR 104
L+ + R+ + +REE E+ L ++++IL +Q+ + ++ E RK EE +R
Sbjct: 731 LEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRR 790
Query: 105 EDQKRAAVEEKRKQKLREEEE----RLEAMMRRSLERTQQLELKKK 146
+ ++ A+ +R+++ R+++E RLE R ER +Q EL +K
Sbjct: 791 QREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRK 836
Score = 46.6 bits (109), Expect = 8e-05
Identities = 30/116 (25%), Positives = 57/116 (49%), Gaps = 14/116 (12%)
Query: 49 LKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQM--------EERWRKLEE 100
L+ +E +R KE +R+K L + QQ E +R + Q ++Q W +
Sbjct: 869 LRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSN 928
Query: 101 QRQREDQKRAAV------EEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSWG 150
+ Q ++ EE+R+++LREE+ R + + ++L++ QQ + +K WG
Sbjct: 929 TTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWG 984
Score = 45.4 bits (106), Expect = 2e-04
Identities = 29/86 (33%), Positives = 52/86 (60%), Gaps = 5/86 (5%)
Query: 58 AKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRK 117
A E+ ++ EK AA+ +Q +++ A ++ +++ EER R+ E +RQ+E+ R EE+RK
Sbjct: 716 ALEQLQQLEKAKAAKLEQ---ERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERK 772
Query: 118 QKLREEEERLEAMMRRSLERTQQLEL 143
+ REEEE +L R ++ E+
Sbjct: 773 R--REEEELARRKQEEALRRQREQEI 796
Score = 45.4 bits (106), Expect = 2e-04
Identities = 42/145 (28%), Positives = 64/145 (44%), Gaps = 33/145 (22%)
Query: 34 RTSQPNYRPQGMEGFLKSDERQRLAKE-----RREEREKCLAAREQQILEKQKRARLQYE 88
R Q R Q E + E +R +E RR++ E REQ+I +++R +
Sbjct: 749 RKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREE-EER 807
Query: 89 KQMEERWRKLEEQRQREDQKRAAVEEKRKQ---------------------KLREEEERL 127
+Q EE R+LEE+R+ E+++R E RKQ +LR EEE
Sbjct: 808 QQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAA 867
Query: 128 ------EAMMRRSLERTQQLELKKK 146
E R+ LE +Q EL ++
Sbjct: 868 RLRHEEEERKRKELEVQRQKELMRQ 892
Score = 42.7 bits (99), Expect = 0.001
Identities = 36/112 (32%), Positives = 66/112 (58%), Gaps = 16/112 (14%)
Query: 49 LKSDERQRLAKERREERE-KCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQ 107
L+ E+ + AK +E RE + A RE++ ++Q+ R Q E+ + R ++ EE+++RE++
Sbjct: 720 LQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEIL--RRQQEEERKRREEE 777
Query: 108 KRA------AVEEKRKQKL-----REEEER--LEAMMRRSLERTQQLELKKK 146
+ A A+ +R+Q++ REEEER E +RR ER ++ E ++K
Sbjct: 778 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRK 829
Score = 42.4 bits (98), Expect = 0.002
Identities = 46/236 (19%), Positives = 100/236 (42%), Gaps = 44/236 (18%)
Query: 332 RKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPT 391
R+ ++E ++RE +A + + E ++ + + + K E +
Sbjct: 781 RRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEE 840
Query: 392 AG--TTDAGEAAKILAEKRRQ-----ARLQKEQEEQERVEKEEQDRLEREELKRKAEEER 444
A + EA + L E R + ARL+ E+EE++R E E Q + E +++ +E
Sbjct: 841 AAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEAL 900
Query: 445 LRLEEEARKQ------------------------------------EEERKRQEEEKKKQ 468
RL+++ ++Q EEER+RQ E++++
Sbjct: 901 RRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRR 960
Query: 469 EGEEKRKAGEEAKRKAEEELL-LKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMR 523
+ E KA ++ +++ +++L + K+++E Q+E A ++ +Q +
Sbjct: 961 QQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQ 1016
Score = 33.1 bits (74), Expect = 0.94
Identities = 24/109 (22%), Positives = 48/109 (44%), Gaps = 7/109 (6%)
Query: 421 ERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEA 480
++V+KE E +E+ + +E + EE K ++ KK EGE+ + G EA
Sbjct: 304 KKVQKEPIP--EEQEMDFRPVDEGEECSDSEGSHNEEAKEPDKTNKK-EGEKTDRVGVEA 360
Query: 481 KRKAEEELLLKEK----QEQEKQEKAMIEKQKEAAETKAREVAEQMRLE 525
+ + + + + QE + E++ E + + E+ R+E
Sbjct: 361 SEETPQTSSSSARPGTPSDHQSQEASQFERKDEPKTEQTEKAEEETRME 409
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 98.2 bits (243), Expect = 2e-20
Identities = 63/166 (37%), Positives = 105/166 (63%), Gaps = 14/166 (8%)
Query: 396 DAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEE---AR 452
+ +AAK L ++RR+A ++ ++EE+ER +EE R + E L+R+ EEER R EEE R
Sbjct: 751 EKAKAAK-LEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARR 809
Query: 453 KQEEERKRQEEEK---KKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKE 509
KQEE +RQ E++ ++Q EE+R+ EEA R+ EE +E++E+ KQE+ + ++++E
Sbjct: 810 KQEEALRRQREQEIALRRQREEEERQQQEEALRRLEER--RREEEERRKQEELLRKQEEE 867
Query: 510 AAETKAREVAEQMRLEREQIMLQIEQERL-----ERKKRIDEIMKR 550
AA+ E Q RLE ++ ++ E RL ERK++ E+ ++
Sbjct: 868 AAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQ 913
Score = 82.0 bits (201), Expect = 2e-15
Identities = 52/158 (32%), Positives = 98/158 (62%), Gaps = 10/158 (6%)
Query: 414 QKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEE--RKRQEEEKKKQEGE 471
Q +Q E+ + K EQ+R E E ++ EEER R +EE R+Q+EE R++QEEE+K++E E
Sbjct: 746 QLQQLEKAKAAKLEQERREAEMRAKREEEERKR-QEELRRQQEEILRRQQEEERKRREEE 804
Query: 472 E--KRKAGEEAKRKAEEELLL---KEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLER 526
E +RK E +R+ E+E+ L +E++E+++QE+A+ ++ E + R E++ ++
Sbjct: 805 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQ 864
Query: 527 EQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKED 564
E+ + +E E ++R++E R R + +++ E+
Sbjct: 865 EEEAAKWAREEEEAQRRLEE--NRLRMEEEAARLRHEE 900
Score = 80.9 bits (198), Expect = 4e-15
Identities = 53/153 (34%), Positives = 93/153 (60%), Gaps = 8/153 (5%)
Query: 402 KILAEKRRQARLQKEQEEQERVEKEEQDRLEREE---LKRKAEEERLRLEEEARKQEEER 458
+IL ++ + R ++E+EE R ++EE R +RE+ L+R+ EEE + +EEA ++ EER
Sbjct: 788 EILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEER 847
Query: 459 KRQEEEKKKQEGEEKRKAGEEAKRKAEEE----LLLKEKQEQEKQEKAMIEKQKEAAETK 514
+R+EEE++KQE E RK EEA + A EE L+E + + ++E A + ++E + K
Sbjct: 848 RREEEERRKQE-ELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRK 906
Query: 515 AREVAEQMRLEREQIMLQIEQERLERKKRIDEI 547
EV Q L R++ Q RL+++++ ++
Sbjct: 907 ELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL 939
Score = 78.2 bits (191), Expect = 3e-14
Identities = 54/169 (31%), Positives = 97/169 (57%), Gaps = 10/169 (5%)
Query: 399 EAAKILAEKRRQA----RLQKEQEEQERVEKEEQDRLEREELKRKAEEE---RLRLEEEA 451
E K E RRQ R Q+E+E + R E+E R + E L+R+ E+E R + EEE
Sbjct: 774 EERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEE 833
Query: 452 RKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAA 511
R+Q+EE R+ EE++++ EE+R+ EE RK EEE K +E+E+ ++ + E +
Sbjct: 834 RQQQEEALRRLEERRRE--EEERRKQEELLRKQEEE-AAKWAREEEEAQRRLEENRLRME 890
Query: 512 ETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQV 560
E AR E+ +R+++ +Q ++E + ++++ E ++R ++ Q+
Sbjct: 891 EEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL 939
Score = 69.7 bits (169), Expect = 9e-12
Identities = 61/244 (25%), Positives = 114/244 (46%), Gaps = 43/244 (17%)
Query: 305 PKTTKPPYPGSPVKYRLPALSGQDMPKRKAEKE-KSNKEREGTLAQQAAGPQGEEALEKH 363
P T P P +L + + + E E ++ +E E Q+ Q EE L +
Sbjct: 734 PLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQ 793
Query: 364 VVDKHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERV 423
++ + A K E + + ++ ++ L++++EE+ER
Sbjct: 794 QEEERKRREEEELARRKQEEA------------------LRRQREQEIALRRQREEEERQ 835
Query: 424 EKEEQ-DRLE---REELKRKAEEERLRLEEE-----ARKQEEERKRQEEEKKKQEGEEKR 474
++EE RLE REE +R+ +EE LR +EE AR++EE ++R EE + + E
Sbjct: 836 QQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRME----- 890
Query: 475 KAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIE 534
EEA R L+ ++E+ K+++ +++QKE + ++ RL+++Q Q+
Sbjct: 891 ---EEAAR-------LRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLA 940
Query: 535 QERL 538
Q +L
Sbjct: 941 QMKL 944
Score = 65.1 bits (157), Expect = 2e-10
Identities = 41/134 (30%), Positives = 82/134 (61%), Gaps = 5/134 (3%)
Query: 434 EELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEK 493
E+L++ + + +LE+E R+ E KR+EEE+K+QE E +R+ E +R+ EEE +E+
Sbjct: 745 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQE-ELRRQQEEILRRQQEEERKRREE 803
Query: 494 QE--QEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERL-ERKKRIDEIMKR 550
+E + KQE+A + +Q+E R+ E+ R ++E+ + ++E+ R E ++R E + R
Sbjct: 804 EELARRKQEEA-LRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 862
Query: 551 TRKSDVPPQVKKED 564
++ + ++E+
Sbjct: 863 KQEEEAAKWAREEE 876
Score = 55.8 bits (133), Expect = 1e-07
Identities = 64/275 (23%), Positives = 116/275 (42%), Gaps = 74/275 (26%)
Query: 328 DMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAAL 387
+M ++ E+E+ +E ++ Q EE ++ ++ A K A + E AL
Sbjct: 766 EMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIAL 825
Query: 388 GKPTAGTT--DAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRL--EREELKRKAEEE 443
+ EA + L E+RR+ +++QEE R ++EE + E EE +R+ EE
Sbjct: 826 RRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEEN 885
Query: 444 RLRLEEEA---RKQEEE---------------RKRQEEEK-------------------- 465
RLR+EEEA R +EEE R+RQ++++
Sbjct: 886 RLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLP 945
Query: 466 -------------------------KKQEGEEKRKAGEEAKRKAEE--ELLLKEKQEQEK 498
+K E E +R+ EE +R+ E + L +++Q+Q++
Sbjct: 946 SSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQ 1005
Query: 499 QEKAMIEKQKEAAETKA-----REVAEQMRLEREQ 528
+ K + TK+ +E A QM+ +++Q
Sbjct: 1006 KLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQ 1040
Score = 52.4 bits (124), Expect = 2e-06
Identities = 33/113 (29%), Positives = 64/113 (56%), Gaps = 20/113 (17%)
Query: 55 QRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAV-- 112
+RL + RREE E+ +++++L KQ+ ++ ++ EE R+LEE R R +++ A +
Sbjct: 842 RRLEERRREEEER---RKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRH 898
Query: 113 -EEKRKQK----------LREEEERLEAMMRRSLERTQ----QLELKKKYSWG 150
EE+RK+K +R+ +++ EA+ R ++ Q Q++L +WG
Sbjct: 899 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 951
Score = 48.1 bits (113), Expect = 3e-05
Identities = 35/119 (29%), Positives = 62/119 (52%), Gaps = 4/119 (3%)
Query: 28 AEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQ-ILEKQKRARLQ 86
AE A R + R + + + R++ +ER+ E+ LA R+Q+ L +Q+ +
Sbjct: 765 AEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIA 824
Query: 87 YEKQMEERWRKLEEQRQRE-DQKRAAVEEKRKQK--LREEEERLEAMMRRSLERTQQLE 142
+Q EE R+ +E+ R +++R EE+RKQ+ LR++EE R E ++LE
Sbjct: 825 LRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLE 883
Score = 47.4 bits (111), Expect = 5e-05
Identities = 30/106 (28%), Positives = 59/106 (55%), Gaps = 8/106 (7%)
Query: 49 LKSDERQRLAKERREEREKC----LAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQR 104
L+ + R+ + +REE E+ L ++++IL +Q+ + ++ E RK EE +R
Sbjct: 758 LEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRR 817
Query: 105 EDQKRAAVEEKRKQKLREEEE----RLEAMMRRSLERTQQLELKKK 146
+ ++ A+ +R+++ R+++E RLE R ER +Q EL +K
Sbjct: 818 QREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRK 863
Score = 46.6 bits (109), Expect = 8e-05
Identities = 30/116 (25%), Positives = 57/116 (49%), Gaps = 14/116 (12%)
Query: 49 LKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQM--------EERWRKLEE 100
L+ +E +R KE +R+K L + QQ E +R + Q ++Q W +
Sbjct: 896 LRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSN 955
Query: 101 QRQREDQKRAAV------EEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSWG 150
+ Q ++ EE+R+++LREE+ R + + ++L++ QQ + +K WG
Sbjct: 956 TTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWG 1011
Score = 45.4 bits (106), Expect = 2e-04
Identities = 29/86 (33%), Positives = 52/86 (60%), Gaps = 5/86 (5%)
Query: 58 AKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRK 117
A E+ ++ EK AA+ +Q +++ A ++ +++ EER R+ E +RQ+E+ R EE+RK
Sbjct: 743 ALEQLQQLEKAKAAKLEQ---ERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERK 799
Query: 118 QKLREEEERLEAMMRRSLERTQQLEL 143
+ REEEE +L R ++ E+
Sbjct: 800 R--REEEELARRKQEEALRRQREQEI 823
Score = 45.4 bits (106), Expect = 2e-04
Identities = 42/145 (28%), Positives = 64/145 (44%), Gaps = 33/145 (22%)
Query: 34 RTSQPNYRPQGMEGFLKSDERQRLAKE-----RREEREKCLAAREQQILEKQKRARLQYE 88
R Q R Q E + E +R +E RR++ E REQ+I +++R +
Sbjct: 776 RKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREE-EER 834
Query: 89 KQMEERWRKLEEQRQREDQKRAAVEEKRKQ---------------------KLREEEERL 127
+Q EE R+LEE+R+ E+++R E RKQ +LR EEE
Sbjct: 835 QQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAA 894
Query: 128 ------EAMMRRSLERTQQLELKKK 146
E R+ LE +Q EL ++
Sbjct: 895 RLRHEEEERKRKELEVQRQKELMRQ 919
Score = 42.7 bits (99), Expect = 0.001
Identities = 36/112 (32%), Positives = 66/112 (58%), Gaps = 16/112 (14%)
Query: 49 LKSDERQRLAKERREERE-KCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQ 107
L+ E+ + AK +E RE + A RE++ ++Q+ R Q E+ + R ++ EE+++RE++
Sbjct: 747 LQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEIL--RRQQEEERKRREEE 804
Query: 108 KRA------AVEEKRKQKL-----REEEER--LEAMMRRSLERTQQLELKKK 146
+ A A+ +R+Q++ REEEER E +RR ER ++ E ++K
Sbjct: 805 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRK 856
Score = 42.4 bits (98), Expect = 0.002
Identities = 46/236 (19%), Positives = 100/236 (42%), Gaps = 44/236 (18%)
Query: 332 RKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPT 391
R+ ++E ++RE +A + + E ++ + + + K E +
Sbjct: 808 RRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEE 867
Query: 392 AG--TTDAGEAAKILAEKRRQ-----ARLQKEQEEQERVEKEEQDRLEREELKRKAEEER 444
A + EA + L E R + ARL+ E+EE++R E E Q + E +++ +E
Sbjct: 868 AAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEAL 927
Query: 445 LRLEEEARKQ------------------------------------EEERKRQEEEKKKQ 468
RL+++ ++Q EEER+RQ E++++
Sbjct: 928 RRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRR 987
Query: 469 EGEEKRKAGEEAKRKAEEELL-LKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMR 523
+ E KA ++ +++ +++L + K+++E Q+E A ++ +Q +
Sbjct: 988 QQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQ 1043
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 98.2 bits (243), Expect = 2e-20
Identities = 63/166 (37%), Positives = 105/166 (63%), Gaps = 14/166 (8%)
Query: 396 DAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEA---R 452
+ +AAK L ++RR+A ++ ++EE+ER +EE R + E L+R+ EEER R EEE R
Sbjct: 730 EKAKAAK-LEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARR 788
Query: 453 KQEEERKRQEEEK---KKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKE 509
KQEE +RQ E++ ++Q EE+R+ EEA R+ EE +E++E+ KQE+ + ++++E
Sbjct: 789 KQEEALRRQREQEIALRRQREEEERQQQEEALRRLEER--RREEEERRKQEELLRKQEEE 846
Query: 510 AAETKAREVAEQMRLEREQIMLQIEQERL-----ERKKRIDEIMKR 550
AA+ E Q RLE ++ ++ E RL ERK++ E+ ++
Sbjct: 847 AAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQ 892
Score = 82.0 bits (201), Expect = 2e-15
Identities = 52/158 (32%), Positives = 98/158 (62%), Gaps = 10/158 (6%)
Query: 414 QKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEE--RKRQEEEKKKQEGE 471
Q +Q E+ + K EQ+R E E ++ EEER R +EE R+Q+EE R++QEEE+K++E E
Sbjct: 725 QLQQLEKAKAAKLEQERREAEMRAKREEEERKR-QEELRRQQEEILRRQQEEERKRREEE 783
Query: 472 E--KRKAGEEAKRKAEEELLL---KEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLER 526
E +RK E +R+ E+E+ L +E++E+++QE+A+ ++ E + R E++ ++
Sbjct: 784 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQ 843
Query: 527 EQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKED 564
E+ + +E E ++R++E R R + +++ E+
Sbjct: 844 EEEAAKWAREEEEAQRRLEE--NRLRMEEEAARLRHEE 879
Score = 80.9 bits (198), Expect = 4e-15
Identities = 53/153 (34%), Positives = 93/153 (60%), Gaps = 8/153 (5%)
Query: 402 KILAEKRRQARLQKEQEEQERVEKEEQDRLEREE---LKRKAEEERLRLEEEARKQEEER 458
+IL ++ + R ++E+EE R ++EE R +RE+ L+R+ EEE + +EEA ++ EER
Sbjct: 767 EILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEER 826
Query: 459 KRQEEEKKKQEGEEKRKAGEEAKRKAEEE----LLLKEKQEQEKQEKAMIEKQKEAAETK 514
+R+EEE++KQE E RK EEA + A EE L+E + + ++E A + ++E + K
Sbjct: 827 RREEEERRKQE-ELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRK 885
Query: 515 AREVAEQMRLEREQIMLQIEQERLERKKRIDEI 547
EV Q L R++ Q RL+++++ ++
Sbjct: 886 ELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL 918
Score = 78.2 bits (191), Expect = 3e-14
Identities = 54/169 (31%), Positives = 97/169 (57%), Gaps = 10/169 (5%)
Query: 399 EAAKILAEKRRQA----RLQKEQEEQERVEKEEQDRLEREELKRKAEEE---RLRLEEEA 451
E K E RRQ R Q+E+E + R E+E R + E L+R+ E+E R + EEE
Sbjct: 753 EERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEE 812
Query: 452 RKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAA 511
R+Q+EE R+ EE++++ EE+R+ EE RK EEE K +E+E+ ++ + E +
Sbjct: 813 RQQQEEALRRLEERRRE--EEERRKQEELLRKQEEE-AAKWAREEEEAQRRLEENRLRME 869
Query: 512 ETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQV 560
E AR E+ +R+++ +Q ++E + ++++ E ++R ++ Q+
Sbjct: 870 EEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL 918
Score = 69.7 bits (169), Expect = 9e-12
Identities = 61/244 (25%), Positives = 114/244 (46%), Gaps = 43/244 (17%)
Query: 305 PKTTKPPYPGSPVKYRLPALSGQDMPKRKAEKE-KSNKEREGTLAQQAAGPQGEEALEKH 363
P T P P +L + + + E E ++ +E E Q+ Q EE L +
Sbjct: 713 PLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQ 772
Query: 364 VVDKHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERV 423
++ + A K E + + ++ ++ L++++EE+ER
Sbjct: 773 QEEERKRREEEELARRKQEEA------------------LRRQREQEIALRRQREEEERQ 814
Query: 424 EKEEQ-DRLE---REELKRKAEEERLRLEEE-----ARKQEEERKRQEEEKKKQEGEEKR 474
++EE RLE REE +R+ +EE LR +EE AR++EE ++R EE + + E
Sbjct: 815 QQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRME----- 869
Query: 475 KAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIE 534
EEA R L+ ++E+ K+++ +++QKE + ++ RL+++Q Q+
Sbjct: 870 ---EEAAR-------LRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLA 919
Query: 535 QERL 538
Q +L
Sbjct: 920 QMKL 923
Score = 65.1 bits (157), Expect = 2e-10
Identities = 41/134 (30%), Positives = 82/134 (61%), Gaps = 5/134 (3%)
Query: 434 EELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEK 493
E+L++ + + +LE+E R+ E KR+EEE+K+QE E +R+ E +R+ EEE +E+
Sbjct: 724 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQE-ELRRQQEEILRRQQEEERKRREE 782
Query: 494 QE--QEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERL-ERKKRIDEIMKR 550
+E + KQE+A + +Q+E R+ E+ R ++E+ + ++E+ R E ++R E + R
Sbjct: 783 EELARRKQEEA-LRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 841
Query: 551 TRKSDVPPQVKKED 564
++ + ++E+
Sbjct: 842 KQEEEAAKWAREEE 855
Score = 55.8 bits (133), Expect = 1e-07
Identities = 64/275 (23%), Positives = 116/275 (42%), Gaps = 74/275 (26%)
Query: 328 DMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAAL 387
+M ++ E+E+ +E ++ Q EE ++ ++ A K A + E AL
Sbjct: 745 EMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIAL 804
Query: 388 GKPTAGTT--DAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRL--EREELKRKAEEE 443
+ EA + L E+RR+ +++QEE R ++EE + E EE +R+ EE
Sbjct: 805 RRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEEN 864
Query: 444 RLRLEEEA---RKQEEE---------------RKRQEEEK-------------------- 465
RLR+EEEA R +EEE R+RQ++++
Sbjct: 865 RLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLP 924
Query: 466 -------------------------KKQEGEEKRKAGEEAKRKAEE--ELLLKEKQEQEK 498
+K E E +R+ EE +R+ E + L +++Q+Q++
Sbjct: 925 SSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQ 984
Query: 499 QEKAMIEKQKEAAETKA-----REVAEQMRLEREQ 528
+ K + TK+ +E A QM+ +++Q
Sbjct: 985 KLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQ 1019
Score = 52.4 bits (124), Expect = 2e-06
Identities = 33/113 (29%), Positives = 64/113 (56%), Gaps = 20/113 (17%)
Query: 55 QRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAV-- 112
+RL + RREE E+ +++++L KQ+ ++ ++ EE R+LEE R R +++ A +
Sbjct: 821 RRLEERRREEEER---RKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRH 877
Query: 113 -EEKRKQK----------LREEEERLEAMMRRSLERTQ----QLELKKKYSWG 150
EE+RK+K +R+ +++ EA+ R ++ Q Q++L +WG
Sbjct: 878 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 930
Score = 48.1 bits (113), Expect = 3e-05
Identities = 35/119 (29%), Positives = 62/119 (52%), Gaps = 4/119 (3%)
Query: 28 AEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQ-ILEKQKRARLQ 86
AE A R + R + + + R++ +ER+ E+ LA R+Q+ L +Q+ +
Sbjct: 744 AEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIA 803
Query: 87 YEKQMEERWRKLEEQRQRE-DQKRAAVEEKRKQK--LREEEERLEAMMRRSLERTQQLE 142
+Q EE R+ +E+ R +++R EE+RKQ+ LR++EE R E ++LE
Sbjct: 804 LRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLE 862
Score = 47.4 bits (111), Expect = 5e-05
Identities = 30/106 (28%), Positives = 59/106 (55%), Gaps = 8/106 (7%)
Query: 49 LKSDERQRLAKERREEREKC----LAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQR 104
L+ + R+ + +REE E+ L ++++IL +Q+ + ++ E RK EE +R
Sbjct: 737 LEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRR 796
Query: 105 EDQKRAAVEEKRKQKLREEEE----RLEAMMRRSLERTQQLELKKK 146
+ ++ A+ +R+++ R+++E RLE R ER +Q EL +K
Sbjct: 797 QREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRK 842
Score = 46.6 bits (109), Expect = 8e-05
Identities = 30/116 (25%), Positives = 57/116 (49%), Gaps = 14/116 (12%)
Query: 49 LKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQM--------EERWRKLEE 100
L+ +E +R KE +R+K L + QQ E +R + Q ++Q W +
Sbjct: 875 LRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSN 934
Query: 101 QRQREDQKRAAV------EEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSWG 150
+ Q ++ EE+R+++LREE+ R + + ++L++ QQ + +K WG
Sbjct: 935 TTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWG 990
Score = 45.4 bits (106), Expect = 2e-04
Identities = 29/86 (33%), Positives = 52/86 (60%), Gaps = 5/86 (5%)
Query: 58 AKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRK 117
A E+ ++ EK AA+ +Q +++ A ++ +++ EER R+ E +RQ+E+ R EE+RK
Sbjct: 722 ALEQLQQLEKAKAAKLEQ---ERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERK 778
Query: 118 QKLREEEERLEAMMRRSLERTQQLEL 143
+ REEEE +L R ++ E+
Sbjct: 779 R--REEEELARRKQEEALRRQREQEI 802
Score = 45.4 bits (106), Expect = 2e-04
Identities = 42/145 (28%), Positives = 64/145 (44%), Gaps = 33/145 (22%)
Query: 34 RTSQPNYRPQGMEGFLKSDERQRLAKE-----RREEREKCLAAREQQILEKQKRARLQYE 88
R Q R Q E + E +R +E RR++ E REQ+I +++R +
Sbjct: 755 RKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREE-EER 813
Query: 89 KQMEERWRKLEEQRQREDQKRAAVEEKRKQ---------------------KLREEEERL 127
+Q EE R+LEE+R+ E+++R E RKQ +LR EEE
Sbjct: 814 QQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAA 873
Query: 128 ------EAMMRRSLERTQQLELKKK 146
E R+ LE +Q EL ++
Sbjct: 874 RLRHEEEERKRKELEVQRQKELMRQ 898
Score = 42.7 bits (99), Expect = 0.001
Identities = 36/112 (32%), Positives = 66/112 (58%), Gaps = 16/112 (14%)
Query: 49 LKSDERQRLAKERREERE-KCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQ 107
L+ E+ + AK +E RE + A RE++ ++Q+ R Q E+ + R ++ EE+++RE++
Sbjct: 726 LQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEIL--RRQQEEERKRREEE 783
Query: 108 KRA------AVEEKRKQKL-----REEEER--LEAMMRRSLERTQQLELKKK 146
+ A A+ +R+Q++ REEEER E +RR ER ++ E ++K
Sbjct: 784 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRK 835
Score = 42.4 bits (98), Expect = 0.002
Identities = 46/236 (19%), Positives = 100/236 (42%), Gaps = 44/236 (18%)
Query: 332 RKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPT 391
R+ ++E ++RE +A + + E ++ + + + K E +
Sbjct: 787 RRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEE 846
Query: 392 AG--TTDAGEAAKILAEKRRQ-----ARLQKEQEEQERVEKEEQDRLEREELKRKAEEER 444
A + EA + L E R + ARL+ E+EE++R E E Q + E +++ +E
Sbjct: 847 AAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEAL 906
Query: 445 LRLEEEARKQ------------------------------------EEERKRQEEEKKKQ 468
RL+++ ++Q EEER+RQ E++++
Sbjct: 907 RRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRR 966
Query: 469 EGEEKRKAGEEAKRKAEEELL-LKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMR 523
+ E KA ++ +++ +++L + K+++E Q+E A ++ +Q +
Sbjct: 967 QQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQ 1022
Score = 33.1 bits (74), Expect = 0.94
Identities = 24/109 (22%), Positives = 48/109 (44%), Gaps = 7/109 (6%)
Query: 421 ERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEA 480
++V+KE E +E+ + +E + EE K ++ KK EGE+ + G EA
Sbjct: 310 KKVQKEPIP--EEQEMDFRPVDEGEECSDSEGSHNEEAKEPDKTNKK-EGEKTDRVGVEA 366
Query: 481 KRKAEEELLLKEK----QEQEKQEKAMIEKQKEAAETKAREVAEQMRLE 525
+ + + + + QE + E++ E + + E+ R+E
Sbjct: 367 SEETPQTSSSSARPGTPSDHQSQEASQFERKDEPKTEQTEKAEEETRME 415
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 98.2 bits (243), Expect = 2e-20
Identities = 63/166 (37%), Positives = 105/166 (63%), Gaps = 14/166 (8%)
Query: 396 DAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEA---R 452
+ +AAK L ++RR+A ++ ++EE+ER +EE R + E L+R+ EEER R EEE R
Sbjct: 730 EKAKAAK-LEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARR 788
Query: 453 KQEEERKRQEEEK---KKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKE 509
KQEE +RQ E++ ++Q EE+R+ EEA R+ EE +E++E+ KQE+ + ++++E
Sbjct: 789 KQEEALRRQREQEIALRRQREEEERQQQEEALRRLEER--RREEEERRKQEELLRKQEEE 846
Query: 510 AAETKAREVAEQMRLEREQIMLQIEQERL-----ERKKRIDEIMKR 550
AA+ E Q RLE ++ ++ E RL ERK++ E+ ++
Sbjct: 847 AAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQ 892
Score = 82.0 bits (201), Expect = 2e-15
Identities = 52/158 (32%), Positives = 98/158 (62%), Gaps = 10/158 (6%)
Query: 414 QKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEE--RKRQEEEKKKQEGE 471
Q +Q E+ + K EQ+R E E ++ EEER R +EE R+Q+EE R++QEEE+K++E E
Sbjct: 725 QLQQLEKAKAAKLEQERREAEMRAKREEEERKR-QEELRRQQEEILRRQQEEERKRREEE 783
Query: 472 E--KRKAGEEAKRKAEEELLL---KEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLER 526
E +RK E +R+ E+E+ L +E++E+++QE+A+ ++ E + R E++ ++
Sbjct: 784 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQ 843
Query: 527 EQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKED 564
E+ + +E E ++R++E R R + +++ E+
Sbjct: 844 EEEAAKWAREEEEAQRRLEE--NRLRMEEEAARLRHEE 879
Score = 80.9 bits (198), Expect = 4e-15
Identities = 53/153 (34%), Positives = 93/153 (60%), Gaps = 8/153 (5%)
Query: 402 KILAEKRRQARLQKEQEEQERVEKEEQDRLEREE---LKRKAEEERLRLEEEARKQEEER 458
+IL ++ + R ++E+EE R ++EE R +RE+ L+R+ EEE + +EEA ++ EER
Sbjct: 767 EILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEER 826
Query: 459 KRQEEEKKKQEGEEKRKAGEEAKRKAEEE----LLLKEKQEQEKQEKAMIEKQKEAAETK 514
+R+EEE++KQE E RK EEA + A EE L+E + + ++E A + ++E + K
Sbjct: 827 RREEEERRKQE-ELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRK 885
Query: 515 AREVAEQMRLEREQIMLQIEQERLERKKRIDEI 547
EV Q L R++ Q RL+++++ ++
Sbjct: 886 ELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL 918
Score = 78.2 bits (191), Expect = 3e-14
Identities = 54/169 (31%), Positives = 97/169 (57%), Gaps = 10/169 (5%)
Query: 399 EAAKILAEKRRQA----RLQKEQEEQERVEKEEQDRLEREELKRKAEEE---RLRLEEEA 451
E K E RRQ R Q+E+E + R E+E R + E L+R+ E+E R + EEE
Sbjct: 753 EERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEE 812
Query: 452 RKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAA 511
R+Q+EE R+ EE++++ EE+R+ EE RK EEE K +E+E+ ++ + E +
Sbjct: 813 RQQQEEALRRLEERRRE--EEERRKQEELLRKQEEE-AAKWAREEEEAQRRLEENRLRME 869
Query: 512 ETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQV 560
E AR E+ +R+++ +Q ++E + ++++ E ++R ++ Q+
Sbjct: 870 EEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL 918
Score = 69.7 bits (169), Expect = 9e-12
Identities = 61/244 (25%), Positives = 114/244 (46%), Gaps = 43/244 (17%)
Query: 305 PKTTKPPYPGSPVKYRLPALSGQDMPKRKAEKE-KSNKEREGTLAQQAAGPQGEEALEKH 363
P T P P +L + + + E E ++ +E E Q+ Q EE L +
Sbjct: 713 PLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQ 772
Query: 364 VVDKHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERV 423
++ + A K E + + ++ ++ L++++EE+ER
Sbjct: 773 QEEERKRREEEELARRKQEEA------------------LRRQREQEIALRRQREEEERQ 814
Query: 424 EKEEQ-DRLE---REELKRKAEEERLRLEEE-----ARKQEEERKRQEEEKKKQEGEEKR 474
++EE RLE REE +R+ +EE LR +EE AR++EE ++R EE + + E
Sbjct: 815 QQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRME----- 869
Query: 475 KAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIE 534
EEA R L+ ++E+ K+++ +++QKE + ++ RL+++Q Q+
Sbjct: 870 ---EEAAR-------LRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLA 919
Query: 535 QERL 538
Q +L
Sbjct: 920 QMKL 923
Score = 65.1 bits (157), Expect = 2e-10
Identities = 41/134 (30%), Positives = 82/134 (61%), Gaps = 5/134 (3%)
Query: 434 EELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEK 493
E+L++ + + +LE+E R+ E KR+EEE+K+QE E +R+ E +R+ EEE +E+
Sbjct: 724 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQE-ELRRQQEEILRRQQEEERKRREE 782
Query: 494 QE--QEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERL-ERKKRIDEIMKR 550
+E + KQE+A + +Q+E R+ E+ R ++E+ + ++E+ R E ++R E + R
Sbjct: 783 EELARRKQEEA-LRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 841
Query: 551 TRKSDVPPQVKKED 564
++ + ++E+
Sbjct: 842 KQEEEAAKWAREEE 855
Score = 55.8 bits (133), Expect = 1e-07
Identities = 64/275 (23%), Positives = 116/275 (42%), Gaps = 74/275 (26%)
Query: 328 DMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAAL 387
+M ++ E+E+ +E ++ Q EE ++ ++ A K A + E AL
Sbjct: 745 EMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIAL 804
Query: 388 GKPTAGTT--DAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRL--EREELKRKAEEE 443
+ EA + L E+RR+ +++QEE R ++EE + E EE +R+ EE
Sbjct: 805 RRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEEN 864
Query: 444 RLRLEEEA---RKQEEE---------------RKRQEEEK-------------------- 465
RLR+EEEA R +EEE R+RQ++++
Sbjct: 865 RLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLP 924
Query: 466 -------------------------KKQEGEEKRKAGEEAKRKAEE--ELLLKEKQEQEK 498
+K E E +R+ EE +R+ E + L +++Q+Q++
Sbjct: 925 SSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQ 984
Query: 499 QEKAMIEKQKEAAETKA-----REVAEQMRLEREQ 528
+ K + TK+ +E A QM+ +++Q
Sbjct: 985 KLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQ 1019
Score = 52.4 bits (124), Expect = 2e-06
Identities = 33/113 (29%), Positives = 64/113 (56%), Gaps = 20/113 (17%)
Query: 55 QRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAV-- 112
+RL + RREE E+ +++++L KQ+ ++ ++ EE R+LEE R R +++ A +
Sbjct: 821 RRLEERRREEEER---RKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRH 877
Query: 113 -EEKRKQK----------LREEEERLEAMMRRSLERTQ----QLELKKKYSWG 150
EE+RK+K +R+ +++ EA+ R ++ Q Q++L +WG
Sbjct: 878 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 930
Score = 48.1 bits (113), Expect = 3e-05
Identities = 35/119 (29%), Positives = 62/119 (52%), Gaps = 4/119 (3%)
Query: 28 AEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQ-ILEKQKRARLQ 86
AE A R + R + + + R++ +ER+ E+ LA R+Q+ L +Q+ +
Sbjct: 744 AEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIA 803
Query: 87 YEKQMEERWRKLEEQRQRE-DQKRAAVEEKRKQK--LREEEERLEAMMRRSLERTQQLE 142
+Q EE R+ +E+ R +++R EE+RKQ+ LR++EE R E ++LE
Sbjct: 804 LRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLE 862
Score = 47.4 bits (111), Expect = 5e-05
Identities = 30/106 (28%), Positives = 59/106 (55%), Gaps = 8/106 (7%)
Query: 49 LKSDERQRLAKERREEREKC----LAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQR 104
L+ + R+ + +REE E+ L ++++IL +Q+ + ++ E RK EE +R
Sbjct: 737 LEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRR 796
Query: 105 EDQKRAAVEEKRKQKLREEEE----RLEAMMRRSLERTQQLELKKK 146
+ ++ A+ +R+++ R+++E RLE R ER +Q EL +K
Sbjct: 797 QREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRK 842
Score = 46.6 bits (109), Expect = 8e-05
Identities = 30/116 (25%), Positives = 57/116 (49%), Gaps = 14/116 (12%)
Query: 49 LKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQM--------EERWRKLEE 100
L+ +E +R KE +R+K L + QQ E +R + Q ++Q W +
Sbjct: 875 LRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSN 934
Query: 101 QRQREDQKRAAV------EEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSWG 150
+ Q ++ EE+R+++LREE+ R + + ++L++ QQ + +K WG
Sbjct: 935 TTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWG 990
Score = 45.4 bits (106), Expect = 2e-04
Identities = 29/86 (33%), Positives = 52/86 (60%), Gaps = 5/86 (5%)
Query: 58 AKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRK 117
A E+ ++ EK AA+ +Q +++ A ++ +++ EER R+ E +RQ+E+ R EE+RK
Sbjct: 722 ALEQLQQLEKAKAAKLEQ---ERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERK 778
Query: 118 QKLREEEERLEAMMRRSLERTQQLEL 143
+ REEEE +L R ++ E+
Sbjct: 779 R--REEEELARRKQEEALRRQREQEI 802
Score = 45.4 bits (106), Expect = 2e-04
Identities = 42/145 (28%), Positives = 64/145 (44%), Gaps = 33/145 (22%)
Query: 34 RTSQPNYRPQGMEGFLKSDERQRLAKE-----RREEREKCLAAREQQILEKQKRARLQYE 88
R Q R Q E + E +R +E RR++ E REQ+I +++R +
Sbjct: 755 RKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREE-EER 813
Query: 89 KQMEERWRKLEEQRQREDQKRAAVEEKRKQ---------------------KLREEEERL 127
+Q EE R+LEE+R+ E+++R E RKQ +LR EEE
Sbjct: 814 QQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAA 873
Query: 128 ------EAMMRRSLERTQQLELKKK 146
E R+ LE +Q EL ++
Sbjct: 874 RLRHEEEERKRKELEVQRQKELMRQ 898
Score = 42.7 bits (99), Expect = 0.001
Identities = 36/112 (32%), Positives = 66/112 (58%), Gaps = 16/112 (14%)
Query: 49 LKSDERQRLAKERREERE-KCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQ 107
L+ E+ + AK +E RE + A RE++ ++Q+ R Q E+ + R ++ EE+++RE++
Sbjct: 726 LQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEIL--RRQQEEERKRREEE 783
Query: 108 KRA------AVEEKRKQKL-----REEEER--LEAMMRRSLERTQQLELKKK 146
+ A A+ +R+Q++ REEEER E +RR ER ++ E ++K
Sbjct: 784 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRK 835
Score = 42.4 bits (98), Expect = 0.002
Identities = 46/236 (19%), Positives = 100/236 (42%), Gaps = 44/236 (18%)
Query: 332 RKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPT 391
R+ ++E ++RE +A + + E ++ + + + K E +
Sbjct: 787 RRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEE 846
Query: 392 AG--TTDAGEAAKILAEKRRQ-----ARLQKEQEEQERVEKEEQDRLEREELKRKAEEER 444
A + EA + L E R + ARL+ E+EE++R E E Q + E +++ +E
Sbjct: 847 AAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEAL 906
Query: 445 LRLEEEARKQ------------------------------------EEERKRQEEEKKKQ 468
RL+++ ++Q EEER+RQ E++++
Sbjct: 907 RRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRR 966
Query: 469 EGEEKRKAGEEAKRKAEEELL-LKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMR 523
+ E KA ++ +++ +++L + K+++E Q+E A ++ +Q +
Sbjct: 967 QQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQ 1022
Score = 33.1 bits (74), Expect = 0.94
Identities = 24/109 (22%), Positives = 48/109 (44%), Gaps = 7/109 (6%)
Query: 421 ERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEA 480
++V+KE E +E+ + +E + EE K ++ KK EGE+ + G EA
Sbjct: 310 KKVQKEPIP--EEQEMDFRPVDEGEECSDSEGSHNEEAKEPDKTNKK-EGEKTDRVGVEA 366
Query: 481 KRKAEEELLLKEK----QEQEKQEKAMIEKQKEAAETKAREVAEQMRLE 525
+ + + + + QE + E++ E + + E+ R+E
Sbjct: 367 SEETPQTSSSSARPGTPSDHQSQEASQFERKDEPKTEQTEKAEEETRME 415
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 91.7 bits (226), Expect = 2e-18
Identities = 61/182 (33%), Positives = 104/182 (57%), Gaps = 16/182 (8%)
Query: 397 AGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEE 456
A E + + E++++ QK + E+ EK +++RL E+ K+KA +++ E RKQEE
Sbjct: 584 ARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE 643
Query: 457 ERKR-----QEEE---------KKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKA 502
E +R QEEE KKK+E +E+ + EAKR AE+ + +QE+ +QE+
Sbjct: 644 EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERR 703
Query: 503 MIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKK 562
E++++ + R++AEQ R REQ LQ E+E ER+K + + K + ++ + KK
Sbjct: 704 EQERREQERREQERQLAEQER-RREQERLQAERELQEREKAL-RLQKEQLQRELEEKKKK 761
Query: 563 ED 564
E+
Sbjct: 762 EE 763
Score = 80.9 bits (198), Expect = 4e-15
Identities = 76/287 (26%), Positives = 135/287 (47%), Gaps = 17/287 (5%)
Query: 331 KRKAEKEKSNKEREGTLAQQAAG--PQGEEALEKHVVDKHAS--EKHAAAAGGKAENSAA 386
+R+ E+ K +E QA Q +E +K + K A EK A + A
Sbjct: 564 RRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKA 623
Query: 387 LGKPTAGTTDAGEAAKILAEKRRQAR-LQKEQEEQERVEKEEQDRLEREELKRKAEEERL 445
K A + EA + E+ R+ R LQ+E+EE+ E ++ + E +E RKA E +
Sbjct: 624 KKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAK- 682
Query: 446 RLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIE 505
RL E+ ++ E++R+E+E+++QE E + + E+E L E++ + +QE+ E
Sbjct: 683 RLAEQREQERREQERREQERREQERRE--------QERREQERQLAEQERRREQERLQAE 734
Query: 506 KQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKEDP 565
++ + E R EQ++ E E+ + EQ+RL ++ +E K+ + + K +
Sbjct: 735 RELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAK--EAAGASKALNV 792
Query: 566 KVGVQPAVCVE-KKTKLVVPNKMEINGLNTCQEVNGVDHAAPETYPQ 611
V VQ C + T +IN N ++N D E +P+
Sbjct: 793 TVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPR 839
Score = 53.5 bits (127), Expect = 7e-07
Identities = 31/109 (28%), Positives = 65/109 (59%), Gaps = 9/109 (8%)
Query: 41 RPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEE 100
+ + E K+ E +RLA++R +ER REQ+ E+++R + + E++ E+ R+L E
Sbjct: 668 KEEEQERLRKAAEAKRLAEQREQER------REQERREQERREQERREQERREQERQLAE 721
Query: 101 QRQREDQKRAAVE---EKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
Q +R +Q+R E ++R++ LR ++E+L+ + ++ +Q L ++
Sbjct: 722 QERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAER 770
Score = 52.8 bits (125), Expect = 1e-06
Identities = 112/618 (18%), Positives = 226/618 (36%), Gaps = 122/618 (19%)
Query: 49 LKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQK 108
++ + + +E +E E Q+ K++R ++ + R+L ++ R Q
Sbjct: 37 IQEEAERMFTREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQL 96
Query: 109 RAAVEEKRKQKLREEEERLEAMMR------RSLERTQQLELKKKYSWGAPLAIGP----- 157
+ R+ + ++ E+L ++ R + R + AP + P
Sbjct: 97 SS-----RRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAATMALAAPSSPTPESPTM 151
Query: 158 ------GGHDACDKLSTSTMSLPKP--TEPPMNKRLSSSTVAISYSPDRVFHVCPRLA-- 207
H C + + + + E + + +S+ + + SP P
Sbjct: 152 LTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQGI 211
Query: 208 PLGPLNPSYKSSPTRNIEKKKATSTSTSGAGDVGKEALSGGEASL--VEKVKRGQRTATS 265
P + K S R +E +S + G+ +G AS + +V G R + +
Sbjct: 212 PTSDEESTPKKSKARILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPRDSPA 271
Query: 266 LPVVNFGSPLRRCEFSGGIPKRPSSPVISKTATKAYPQSPKTTKPPYPGSPVKYRLPALS 325
P SP R + +P S+P S+T +++ SP P P + + ++
Sbjct: 272 FP----DSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSPSP-QVLAQKYSLVA 326
Query: 326 GQDMPKRKAEKEKSNKEREGTLAQ------------------QAAGPQGEEALEKHVVDK 367
Q+ R+A + + K E A Q G + +E E+
Sbjct: 327 KQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEE-AEPV 385
Query: 368 HASEKHAAAAGG---------KAENSAALGKPTAGTTDAGEAAKILAEKRR--------Q 410
A+E G + NS KP A + + A + A+ + Q
Sbjct: 386 AAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQ 445
Query: 411 ARLQKEQEEQERVEKEEQDRLEREELKRKAEE---------------------------- 442
+ +K +Q E +E+ LE EEL+ +
Sbjct: 446 SARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQML 505
Query: 443 ------------------ERLRLEEEARKQEEERKRQEEEKKKQEGEE-KRKAGEEAKRK 483
LR++ + E+ER+R E ++K+E E+ +R+ EE KR+
Sbjct: 506 MTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRR 565
Query: 484 AEEELLLKEKQEQEKQEKA------MIEKQKEAAETKAREVAEQMRLEREQIMLQIEQER 537
EE+ LK ++ K +A M E++K+ E K ++ E+ +E+ + + + ++
Sbjct: 566 RLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKK 625
Query: 538 LERKKRIDEIMKRTRKSD 555
K+++E+ R ++ +
Sbjct: 626 KAAAKKMEEVEARRKQEE 643
Score = 51.6 bits (122), Expect = 3e-06
Identities = 55/198 (27%), Positives = 91/198 (45%), Gaps = 19/198 (9%)
Query: 34 RTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEE 93
R Q + E + ERQ +ERR E+E+ A RE Q E++K RLQ E+
Sbjct: 697 RREQERREQERREQERREQERQLAEQERRREQERLQAERELQ--EREKALRLQKEQLQ-- 752
Query: 94 RWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSW---- 149
R+LEE++++E+Q+R A E++ Q+ +E++ + A ++L T ++ S+
Sbjct: 753 --RELEEKKKKEEQQRLA--ERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTP 808
Query: 150 ---GAPLAIGPG--GHDACDKLSTSTMSLPKPTEPPMNK--RLSSSTVAISYSPDRVFHV 202
AP I P G D ST + P+ P + LS + + Y P + +
Sbjct: 809 QGHRAPPKINPDNYGMDLNSDDSTDDEAHPRKPIPTWARGTPLSQAIIHQYYHPPNLLEL 868
Query: 203 CPRLAPLGPLNPSYKSSP 220
+ PL + KS P
Sbjct: 869 FGTILPLDLEDIFKKSKP 886
Score = 48.9 bits (115), Expect = 2e-05
Identities = 32/105 (30%), Positives = 64/105 (60%), Gaps = 11/105 (10%)
Query: 48 FLKSDERQR-----LAKERREEREKCLAARE-QQILEKQKRARLQYEKQMEERWRKLEEQ 101
+L+ +E +R L K++ EE+E+ A E +++ E++++ R + E++ +ER + +
Sbjct: 650 WLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERRE 709
Query: 102 RQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
++R +Q+R E++R R E+ERL+A R ER + L L+K+
Sbjct: 710 QERREQERQLAEQER----RREQERLQA-ERELQEREKALRLQKE 749
Score = 48.5 bits (114), Expect = 2e-05
Identities = 42/111 (37%), Positives = 65/111 (58%), Gaps = 15/111 (13%)
Query: 49 LKSDERQRL--AKERREER-EKCLAARE--QQILEKQKRARLQYEKQMEERWRKLEEQRQ 103
++ D+R+RL K +REER K L ARE +Q+ E++K+ Q Q++E+ K +E+R
Sbjct: 559 VEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERL 618
Query: 104 REDQ--KRAA------VEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
E++ K+AA VE +RKQ+ EE RL + + ER Q L+KK
Sbjct: 619 AEEKAKKKAAAKKMEEVEARRKQE--EEARRLRWLQQEEEERRHQELLQKK 667
Score = 45.1 bits (105), Expect = 2e-04
Identities = 26/93 (27%), Positives = 45/93 (48%)
Query: 48 FLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQ 107
F + DE+ AKE R EK + +E+ + R Q E+ RW + EE+ +R +
Sbjct: 603 FAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQE 662
Query: 108 KRAAVEEKRKQKLREEEERLEAMMRRSLERTQQ 140
+E+ +++LR+ E +R ER +Q
Sbjct: 663 LLQKKKEEEQERLRKAAEAKRLAEQREQERREQ 695
Score = 41.2 bits (95), Expect = 0.003
Identities = 29/91 (31%), Positives = 53/91 (58%), Gaps = 16/91 (17%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKR 109
+ +E +RL ++EE E+ R Q++L+K+K ++ +ER RK E ++ +Q+
Sbjct: 641 QEEEARRLRWLQQEEEER----RHQELLQKKK-------EEEQERLRKAAEAKRLAEQRE 689
Query: 110 AAVEEKRKQKLREEEERLEAMMRRSLERTQQ 140
+E+R+Q+ RE+E R + RR ER +Q
Sbjct: 690 ---QERREQERREQERREQE--RREQERREQ 715
Score = 40.0 bits (92), Expect = 0.008
Identities = 26/112 (23%), Positives = 58/112 (51%), Gaps = 6/112 (5%)
Query: 43 QGMEGFLKSDE-----RQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRK 97
Q +E + +E RQ++ +++R E+ RE++ L K +AR + E+ EE+ ++
Sbjct: 540 QRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREER-LRKVLQARERVEQMKEEKKKQ 598
Query: 98 LEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
+E++ + D+K +E+R + + +++ M R +Q E ++ W
Sbjct: 599 IEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRW 650
Score = 37.7 bits (86), Expect = 0.038
Identities = 28/100 (28%), Positives = 56/100 (56%), Gaps = 8/100 (8%)
Query: 49 LKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQME-ERWRKLEEQRQREDQ 107
+K ++++++ ++ + EK A+E+++ E++ + + +K E E RK EE+ +R
Sbjct: 591 MKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRW 650
Query: 108 KRAAVEEKRKQKL-----REEEERLE--AMMRRSLERTQQ 140
+ EE+R Q+L EE+ERL A +R E+ +Q
Sbjct: 651 LQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQ 690
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 89.4 bits (220), Expect = 1e-17
Identities = 115/520 (22%), Positives = 215/520 (41%), Gaps = 84/520 (16%)
Query: 53 ERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAV 112
E +R+A +R ++ E+ AARE++ +Q+R R +KQ EE ++ +Q + Q
Sbjct: 21 EAERIAYQRNDDDEE-EAARERRRRARQERLR---QKQEEESLGQVTDQVEVNAQNSVPD 76
Query: 113 EEKRK----------------QKLREEEERLEAMMRRSLERTQQLELKKKYSWGAPLAIG 156
EE + ++L EER + ++ +LER ++ +
Sbjct: 77 EEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFD-------------- 122
Query: 157 PGGHDACDKLSTSTMSLPKPTEPPMNKRLSSSTVAISYSPDRVFHVCPRLAPLGPLNPSY 216
P DA L + M K S + Y + V SY
Sbjct: 123 PTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETV----------TKSY 172
Query: 217 KSSPTRNIEKKKATSTSTSGAGDVGKEALSGGEASLVEKVKRGQRTATSLPVVNFGSPLR 276
+ + R+ E+ K E EK KRG + V+
Sbjct: 173 QKNDWRDAEENKKEDKEK--------------EEEEEEKPKRGSIGENQVEVMVEEKTTE 218
Query: 277 RCEFSGGIPKRPSSPVISKTATKAYPQSPKTTKPPYPGSPVKYRLPALSGQDMPKRKAEK 336
E + V+S + + PK + GS + +D + +AE+
Sbjct: 219 SQE---------ETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAER 269
Query: 337 EKSN-KEREGTLAQQAAGPQGEEALEKHVVDKHA----SEKHAAAAGGKAENSAALGKPT 391
+ +ERE A+Q +K + D+ A EK AA + E
Sbjct: 270 ARLEAEERERIKAEQ----------DKKIADERARIEAEEKAAAQERERREAEERERMRE 319
Query: 392 AGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEA 451
A E +I E++R A ++ +E+E+ EE+ R++ EE + E +R R EEE
Sbjct: 320 EEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEE 379
Query: 452 R-KQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEA 510
+ K EE+++ ++ E+KK +E + GE+ ++K E + + ++K +++K + A+++KQ E
Sbjct: 380 KAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEE 439
Query: 511 AETKAREVAEQMRLEREQIML-QIEQERLERKKRIDEIMK 549
TK + E+++ ++ +I+ E++++ K E +K
Sbjct: 440 KGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVK 479
Score = 85.9 bits (211), Expect = 1e-16
Identities = 68/238 (28%), Positives = 125/238 (52%), Gaps = 31/238 (13%)
Query: 334 AEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAE-NSAALGKPTA 392
+E+ K +ERE QG + + H + ++ A A + E K
Sbjct: 235 SEEPKQEEERE----------QGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQ 284
Query: 393 GTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEAR 452
A E A+I AE++ A +E+ER E EE++R+ EE ++A EER R++EE +
Sbjct: 285 DKKIADERARIEAEEKAAA------QERERREAEERERMREEE--KRAAEERQRIKEEEK 336
Query: 453 KQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAE 512
+ EER+R +EE+K+ EE+++ EE KR AEE +++ E++EKA +E+QK +
Sbjct: 337 RAAEERQRIKEEEKR-AAEERQRIKEEEKRAAEE----RQRARAEEEEKAKVEEQKRNKQ 391
Query: 513 TKAREVA-EQMRLEREQIMLQIEQERLERKKRIDE------IMKRTRKSDVPPQVKKE 563
+ ++ A ++ +++ E++ +IE + + KK ++ + K+ + Q K+E
Sbjct: 392 LEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKRE 449
Score = 79.7 bits (195), Expect = 9e-15
Identities = 69/248 (27%), Positives = 120/248 (48%), Gaps = 31/248 (12%)
Query: 333 KAEKEKSNKEREG-------TLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSA 385
K EK +S +ER T + Q + E +K +K E+ G EN
Sbjct: 149 KEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQV 208
Query: 386 ALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQER-VEKEEQDRLER--EELKRKAEE 442
+ TT++ E +++ K Q ++ ++E+ER +E E+ EE K +AE
Sbjct: 209 EV-MVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEA 267
Query: 443 ERLRLEEEARKQ----------------EEERKRQEEEKKKQEGEEKRKAGEEAKRKAEE 486
ER RLE E R++ E E K +E++++E EE+ + EE KR AEE
Sbjct: 268 ERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEE 327
Query: 487 ELLLKEKQEQEKQEKAMI-EKQKEAAETKAREVAEQMRLEREQIMLQIEQE---RLERKK 542
+KE++++ +E+ I E++K AAE + R E+ R E+ + E+E ++E +K
Sbjct: 328 RQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQK 387
Query: 543 RIDEIMKR 550
R ++ ++
Sbjct: 388 RNKQLEEK 395
Score = 77.4 bits (189), Expect = 4e-14
Identities = 107/473 (22%), Positives = 196/473 (41%), Gaps = 53/473 (11%)
Query: 51 SDERQRLAKERREEREK-----CLAAREQQILEKQKRARLQYEK---QMEERWRKLEEQR 102
++E ++ KE+ EE E+ + + +++ ++K Q E ++ EE +
Sbjct: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPK 239
Query: 103 QREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSWGAPLAIGPGGHDA 162
Q E++++ + E +K+ EE++ R LE ++ +K + +A +A
Sbjct: 240 QEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQD--KKIADERARIEA 297
Query: 163 CDKLSTSTMSLPKPTEPPM----NKRLSSSTVAISYSPDRVFHVCPRLAPLGPLNPSYKS 218
+K + + E KR + I R R+ K
Sbjct: 298 EEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRI----------KE 347
Query: 219 SPTRNIEKKKATSTSTSGAGDVGKEALSGGEASL-VEKVKRGQRTATSLPVVNF----GS 273
R E+++ A + + A + E VE+ KR ++ + G
Sbjct: 348 EEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGE 407
Query: 274 PLRRCEFSGGIPKRPSSPVISKTATKAYPQSPKTTKPPYPGSPVKYRLPALSGQDMPKRK 333
+ + + ++ + +TA K TK ++ P +++ K
Sbjct: 408 KVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEK 467
Query: 334 AEKEKSNKEREGTLAQQAAG------PQGEEALEKHVVDKHASEKHAAAAGGKA--ENSA 385
+K+K KE + + G GE K KH +E + GG+A +
Sbjct: 468 IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKL---KH-TENTFSRPGGRASVDTKE 523
Query: 386 ALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDR-LEREELKRKAEEER 444
A G P EA K L E RR+ R + E EE E++++++Q+ LE EELK+K EE R
Sbjct: 524 AEGAPQV------EAGKRLEELRRR-RGETESEEFEKLKQKQQEAALELEELKKKREERR 576
Query: 445 LRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQE 497
LEEE E+ RK++E ++K +E EEKR+ EE +R+ E ++K ++
Sbjct: 577 KVLEEE----EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPED 625
Score = 63.2 bits (152), Expect = 9e-10
Identities = 55/219 (25%), Positives = 110/219 (50%), Gaps = 24/219 (10%)
Query: 414 QKEQEEQERVEKEEQDR---------LEREELKRKAEEERL-------RLEEEARKQEEE 457
+KE +E+E E+E+ R + EE +++EE + ++ E KQEEE
Sbjct: 184 KKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEE 243
Query: 458 RKRQEEE----KKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQE-KQEKAMIEKQKEAA- 511
R++ +E +K +E +++R E A+ +AEE +K +Q+++ E+A IE +++AA
Sbjct: 244 REQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAA 303
Query: 512 -ETKAREVAEQMRLEREQIMLQIEQERL-ERKKRIDEIMKRTRKSDVPPQVKKEDPKVGV 569
E + RE E+ R+ E+ E++R+ E +KR E +R ++ + +++ K
Sbjct: 304 QERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEE 363
Query: 570 QPAVCVEKKTKLVVPNKMEINGLNTCQEVNGVDHAAPET 608
+ A ++ + K ++ +++ HA ET
Sbjct: 364 KRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQET 402
Score = 57.8 bits (138), Expect = 4e-08
Identities = 51/196 (26%), Positives = 88/196 (44%), Gaps = 34/196 (17%)
Query: 405 AEKRRQARLQKEQEEQERVEKEEQDRLEREELK---RKAEEERLRLEEEARKQEEERKRQ 461
AE + +K + QER E EE + + + K R AEE + +E+ ++EE+ KR
Sbjct: 142 AENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRG 201
Query: 462 E----------EEKKKQEGEE-------------KRKAGEEAKRKAEEELLLKEKQEQEK 498
EEK + EE + EE + + +E+ EK E+E
Sbjct: 202 SIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEED 261
Query: 499 QEKAMIEKQKEAAETKAREVAEQ--------MRLEREQIMLQIEQERLERKKRIDEIMKR 550
+E+A E+ + AE + R AEQ R+E E+ E+ER E ++R +
Sbjct: 262 KERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEE 321
Query: 551 TRKSDVPPQVKKEDPK 566
R ++ ++K+E+ +
Sbjct: 322 KRAAEERQRIKEEEKR 337
Score = 56.6 bits (135), Expect = 8e-08
Identities = 63/283 (22%), Positives = 136/283 (48%), Gaps = 24/283 (8%)
Query: 331 KRKAEKEKSNKEREGTLAQQAAGPQGEEA----LEKHVVDKHASEKHAAAAGGKAENSAA 386
KR AE+ + KE E A++ + EE +E+ +K EK A K +
Sbjct: 350 KRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKV 409
Query: 387 LGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEE---E 443
K + +A + +K + A L+K+ EE+ + ++++L+ ++ K EE E
Sbjct: 410 EQKIEGKWVNEKKAQE---DKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDE 466
Query: 444 RLRLEEEARKQEE---ERKRQEEEKKKQEGE---EKRKAGEEA----KRKAEEELLLKEK 493
+++ ++E +++ + +RK+ E K Q GE K K E +A + E
Sbjct: 467 KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEG 526
Query: 494 QEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQ---ERLERKKRIDEIMKR 550
Q + K + E ++ ET++ E E+++ ++++ L++E+ +R ER+K ++E +R
Sbjct: 527 APQVEAGKRLEELRRRRGETESEEF-EKLKQKQQEAALELEELKKKREERRKVLEEEEQR 585
Query: 551 TRKSDVPPQVKKEDPKVGVQPAVCVEKKTKLVVPNKMEINGLN 593
++ + ++++E+ K ++ + + KM +GL+
Sbjct: 586 RKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLS 628
Score = 53.5 bits (127), Expect = 7e-07
Identities = 86/391 (21%), Positives = 148/391 (37%), Gaps = 50/391 (12%)
Query: 36 SQPNYRPQGMEGFLKSDERQRLAKERR--EEREKCLAAREQQILEKQKRARLQYEKQMEE 93
+Q R + E +E +R A+ER+ +E EK A Q+I E++KRA EE
Sbjct: 303 AQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRA-------AEE 355
Query: 94 RWR-KLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSWGAP 152
R R K EE+R E+++RA EE+ K K+ E+ +R +QLE KK
Sbjct: 356 RQRIKEEEKRAAEERQRARAEEEEKAKVEEQ------------KRNKQLEEKKHAMQETK 403
Query: 153 LAIGPGGHDACDKLSTSTMSLPKPTEPPMNKRLSSSTVAISYSPDRVFHVCPRLAPLGPL 212
+ G K+ ++ K E + + V ++ V + L
Sbjct: 404 IK----GEKVEQKIEGKWVNEKKAQEDKL-----QTAVLKKQGEEKGTKVQAKREKLQED 454
Query: 213 NPSYKSSPTRN--IEKKKATSTSTSGAGDVGK---EALSGGEASLVEKVKRGQRTATSLP 267
P++K ++ I+K K D K E S + K+K + T
Sbjct: 455 KPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENT----- 509
Query: 268 VVNFGSPLRRCEFSGGIPKRPSSPVISKTATKAYPQSPKTTKPPYPGSPVKYRLPALSGQ 327
F P R + K + + +T + K + AL +
Sbjct: 510 ---FSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELE 566
Query: 328 DMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAAL 387
++ K++ E+ K +E E Q+ A + E EK + + + A AA + +
Sbjct: 567 ELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQK----- 621
Query: 388 GKPTAGTTDAGEAAKILAEKRRQARLQKEQE 418
P G +D + K K ++++ E
Sbjct: 622 -MPEDGLSDDKKPFKCFTPKGSSLKIEERAE 651
Score = 51.2 bits (121), Expect = 3e-06
Identities = 30/108 (27%), Positives = 66/108 (61%), Gaps = 10/108 (9%)
Query: 49 LKSDERQRLAKERR----EEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQ- 103
++ ++++R ER EERE+ A ++++I +++ R + + +ER R+ E+R+
Sbjct: 257 MEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERER 316
Query: 104 -REDQKRAAVEEKR----KQKLREEEERLEAMMRRSLERTQQLELKKK 146
RE++KRAA E +R +++ EE +R++ +R+ E Q+++ ++K
Sbjct: 317 MREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEK 364
Score = 47.0 bits (110), Expect = 6e-05
Identities = 27/123 (21%), Positives = 65/123 (52%), Gaps = 10/123 (8%)
Query: 31 GAVRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQ 90
G + + +P + +G SDE K E++E+ A R + E+++R + + +K+
Sbjct: 231 GQISSEEPKQEEEREQG---SDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKK 287
Query: 91 MEERWRKLEEQRQREDQKRAAVEEKRKQKLREEE-------ERLEAMMRRSLERTQQLEL 143
+ + ++E + + Q+R E + ++++REEE +R++ +R+ E Q+++
Sbjct: 288 IADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKE 347
Query: 144 KKK 146
++K
Sbjct: 348 EEK 350
Score = 46.6 bits (109), Expect = 8e-05
Identities = 64/222 (28%), Positives = 98/222 (44%), Gaps = 58/222 (26%)
Query: 406 EKRRQARLQKEQE---EQERVEKEEQDRLERE---ELKRKAEEERLRLEEEARKQEEERK 459
E+RR+ R QK +E E ER+ + D E E E +R+A +ERLR +KQEEE
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLR-----QKQEEESL 59
Query: 460 RQ--------------EEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIE 505
Q +EE K + + +EA A E L + ++ ++K+ + +E
Sbjct: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEA---AFLERLARREERRQKRLQEALE 116
Query: 506 KQKEAAET------------KAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRK 553
+QKE T + AE E+E+ + QER E ++ + + K +K
Sbjct: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEE-KSESRQERYEIEE-TETVTKSYQK 174
Query: 554 SD--VPPQVKKED----------PKVGV----QPAVCVEKKT 579
+D + KKED PK G Q V VE+KT
Sbjct: 175 NDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKT 216
Score = 45.4 bits (106), Expect = 2e-04
Identities = 39/123 (31%), Positives = 58/123 (47%), Gaps = 21/123 (17%)
Query: 10 TGSRPEGTARGTSLPGKIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCL 69
T SRP G A +V T + PQ G + R+R + EE EK
Sbjct: 509 TFSRPGGRA-------------SVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLK 555
Query: 70 AAREQQILEKQKRARLQYEKQMEERWRKLEEQRQR---EDQKRAAVEEKRKQKLREEEER 126
+++ LE + + +K+ EER + LEE+ QR E+ R EE+ K++L+EE ER
Sbjct: 556 QKQQEAALELE-----ELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIER 610
Query: 127 LEA 129
A
Sbjct: 611 RRA 613
Score = 43.5 bits (101), Expect = 7e-04
Identities = 45/219 (20%), Positives = 100/219 (45%), Gaps = 11/219 (5%)
Query: 423 VEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKR 482
V+ +E + + E ++ EE R R E ++ E+ K++++E + E K+K E K
Sbjct: 519 VDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRK- 577
Query: 483 KAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKK 542
+L+E++++ KQE+A + ++E + + +E E+ R E + ++ ++ L K
Sbjct: 578 ------VLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDK 631
Query: 543 RIDEIMKRTRKSDVPPQVKKEDPKVGVQPAVCVEKKTKLVVPNKMEINGLNTCQEVNGVD 602
+ + + S + + + E VQ + V+ + + +K++ + G
Sbjct: 632 KPFKCF-TPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTK 690
Query: 603 HAAPETYPQDIFSNGLKPAGGLIHLDALDGKSNSLDDST 641
A P + S+ PA G+ ++ ++ K N T
Sbjct: 691 SAKP---TKPAASDLPVPAEGVRNIKSMWEKGNVFSSPT 726
Score = 41.2 bits (95), Expect = 0.003
Identities = 39/132 (29%), Positives = 58/132 (43%), Gaps = 26/132 (19%)
Query: 429 DRLEREELKRKAEEERLRL-------------EEEARKQEEERKRQEEEKKKQEGEEKRK 475
D ER R+ + E +RL EEEA ++ R RQE ++KQE E +
Sbjct: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
Query: 476 AGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAA--ETKAREVAEQMRLEREQIMLQI 533
++ + A+ + +++ + +E EAA E AR R ER Q L
Sbjct: 62 VTDQVEVNAQNS--VPDEEAKTTTTNTQVEGDDEAAFLERLAR------REERRQKRL-- 111
Query: 534 EQERLERKKRID 545
QE LER+K D
Sbjct: 112 -QEALERQKEFD 122
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 89.4 bits (220), Expect = 1e-17
Identities = 94/373 (25%), Positives = 167/373 (44%), Gaps = 34/373 (9%)
Query: 211 PLNPSYKSSPTRNIEKKKATSTSTSGAGDV-GKEALSGGEASLVEKVKRGQRTATSLPVV 269
P N + ++ T N K A+S T AG K + G + +R + ++ +
Sbjct: 402 PHNDTEIANSTPN-PKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSEL 460
Query: 270 NFGSPLRRCEFSGGIPKRPSSPVISKTATKAYPQSPKTTKPPY----PGSPVKYRLPALS 325
+ L E K PSSP + + T + P S + + +
Sbjct: 461 DEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFI 520
Query: 326 GQDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSA 385
++ P R KEK + E ++ A E L + V++ +K K +
Sbjct: 521 KRNTPLRMDPKEKERQRLENLRRKEEA-----EQLRRQKVEE---DKRRRLEEVKLKREE 572
Query: 386 ALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKA----- 440
L K A E + + E++++ QK + E+ EK +++RL E+ K+KA
Sbjct: 573 RLRK----VLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKM 628
Query: 441 ---------EEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLK 491
EEE RL +++EE R ++ +KKK+E +E+ + EAKR AE+ +
Sbjct: 629 EEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQER 688
Query: 492 EKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRT 551
+QE+ +QE+ E++++ + R++AEQ R REQ LQ E+E ER+K + + K
Sbjct: 689 REQERREQERREQERREQERREQERQLAEQER-RREQERLQAERELQEREKAL-RLQKEQ 746
Query: 552 RKSDVPPQVKKED 564
+ ++ + KKE+
Sbjct: 747 LQRELEEKKKKEE 759
Score = 80.9 bits (198), Expect = 4e-15
Identities = 76/287 (26%), Positives = 135/287 (47%), Gaps = 17/287 (5%)
Query: 331 KRKAEKEKSNKEREGTLAQQAAG--PQGEEALEKHVVDKHAS--EKHAAAAGGKAENSAA 386
+R+ E+ K +E QA Q +E +K + K A EK A + A
Sbjct: 560 RRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKA 619
Query: 387 LGKPTAGTTDAGEAAKILAEKRRQAR-LQKEQEEQERVEKEEQDRLEREELKRKAEEERL 445
K A + EA + E+ R+ R LQ+E+EE+ E ++ + E +E RKA E +
Sbjct: 620 KKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAK- 678
Query: 446 RLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIE 505
RL E+ ++ E++R+E+E+++QE E + + E+E L E++ + +QE+ E
Sbjct: 679 RLAEQREQERREQERREQERREQERRE--------QERREQERQLAEQERRREQERLQAE 730
Query: 506 KQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKEDP 565
++ + E R EQ++ E E+ + EQ+RL ++ +E K+ + + K +
Sbjct: 731 RELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAK--EAAGASKALNV 788
Query: 566 KVGVQPAVCVE-KKTKLVVPNKMEINGLNTCQEVNGVDHAAPETYPQ 611
V VQ C + T +IN N ++N D E +P+
Sbjct: 789 TVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPR 835
Score = 53.5 bits (127), Expect = 7e-07
Identities = 31/109 (28%), Positives = 65/109 (59%), Gaps = 9/109 (8%)
Query: 41 RPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEE 100
+ + E K+ E +RLA++R +ER REQ+ E+++R + + E++ E+ R+L E
Sbjct: 664 KEEEQERLRKAAEAKRLAEQREQER------REQERREQERREQERREQERREQERQLAE 717
Query: 101 QRQREDQKRAAVE---EKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
Q +R +Q+R E ++R++ LR ++E+L+ + ++ +Q L ++
Sbjct: 718 QERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAER 766
Score = 52.4 bits (124), Expect = 2e-06
Identities = 114/614 (18%), Positives = 225/614 (36%), Gaps = 118/614 (19%)
Query: 49 LKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQK 108
++ + + +E +E E Q+ K++R ++ + R+L ++ R Q
Sbjct: 37 IQEEAERMFTREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQL 96
Query: 109 RAAVEEKRKQKLREEEERLEAMMR------RSLERTQQLELKKKYSWGAPLAIGP----- 157
+ R+ + ++ E+L ++ R + R + AP + P
Sbjct: 97 SS-----RRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAATMALAAPSSPTPESPTM 151
Query: 158 ------GGHDACDKLSTSTMSLPKP--TEPPMNKRLSSSTVAISYSPDRVFHVCPRLA-- 207
H C + + + + E + + +S+ + + SP P
Sbjct: 152 LTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQGI 211
Query: 208 PLGPLNPSYKSSPTRNIEKKKATSTSTSGAGDVGKEALSGGEASL--VEKVKRGQRTATS 265
P + K S R +E +S + G+ +G AS + +V G R + +
Sbjct: 212 PTSDEESTPKKSKARILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPRDSPA 271
Query: 266 LPVVNFGSPLRRCEFSGGIPKRPSSPVISKTATKAYPQSPKTTKPPYPGSPVKYRLPALS 325
P SP R + +P S+P S+T +++ SP P P + + ++
Sbjct: 272 FP----DSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSPSP-QVLAQKYSLVA 326
Query: 326 GQDMPKRKAEKEKSNKEREGTLAQ------------------QAAGPQGEEALEKHVVDK 367
Q+ R+A + + K E A Q G + +E E+
Sbjct: 327 KQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEE-AEPV 385
Query: 368 HASEKHAAAAGG---------KAENSAALGKPTAGTTDAGEAAKILAEKRR--------Q 410
A+E G + NS KP A + + A + A+ + Q
Sbjct: 386 AAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQ 445
Query: 411 ARLQKEQEEQERVEKEEQDRLEREELK--------------RKAEEERLRLEEEARKQ-- 454
+ +K +Q E +E+ LE EEL+ + R L R Q
Sbjct: 446 SARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQML 505
Query: 455 --------------------------EEERKRQEEEKKKQEGEE-KRKAGEEAKRKAEEE 487
E+ER+R E ++K+E E+ +R+ EE KR+ EE
Sbjct: 506 MTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEE 565
Query: 488 LLLKEKQEQEKQEKA------MIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERK 541
+ LK ++ K +A M E++K+ E K ++ E+ +E+ + + + ++
Sbjct: 566 VKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAA 625
Query: 542 KRIDEIMKRTRKSD 555
K+++E+ R ++ +
Sbjct: 626 KKMEEVEARRKQEE 639
Score = 51.6 bits (122), Expect = 3e-06
Identities = 55/198 (27%), Positives = 91/198 (45%), Gaps = 19/198 (9%)
Query: 34 RTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEE 93
R Q + E + ERQ +ERR E+E+ A RE Q E++K RL Q E+
Sbjct: 693 RREQERREQERREQERREQERQLAEQERRREQERLQAERELQ--EREKALRL----QKEQ 746
Query: 94 RWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSW---- 149
R+LEE++++E+Q+R A E++ Q+ +E++ + A ++L T ++ S+
Sbjct: 747 LQRELEEKKKKEEQQRLA--ERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTP 804
Query: 150 ---GAPLAIGPG--GHDACDKLSTSTMSLPKPTEPPMNK--RLSSSTVAISYSPDRVFHV 202
AP I P G D ST + P+ P + LS + + Y P + +
Sbjct: 805 QGHRAPPKINPDNYGMDLNSDDSTDDEAHPRKPIPTWARGTPLSQAIIHQYYHPPNLLEL 864
Query: 203 CPRLAPLGPLNPSYKSSP 220
+ PL + KS P
Sbjct: 865 FGTILPLDLEDIFKKSKP 882
Score = 48.9 bits (115), Expect = 2e-05
Identities = 32/105 (30%), Positives = 64/105 (60%), Gaps = 11/105 (10%)
Query: 48 FLKSDERQR-----LAKERREEREKCLAARE-QQILEKQKRARLQYEKQMEERWRKLEEQ 101
+L+ +E +R L K++ EE+E+ A E +++ E++++ R + E++ +ER + +
Sbjct: 646 WLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERRE 705
Query: 102 RQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
++R +Q+R E++R R E+ERL+A R ER + L L+K+
Sbjct: 706 QERREQERQLAEQER----RREQERLQA-ERELQEREKALRLQKE 745
Score = 48.5 bits (114), Expect = 2e-05
Identities = 42/111 (37%), Positives = 65/111 (58%), Gaps = 15/111 (13%)
Query: 49 LKSDERQRL--AKERREER-EKCLAARE--QQILEKQKRARLQYEKQMEERWRKLEEQRQ 103
++ D+R+RL K +REER K L ARE +Q+ E++K+ Q Q++E+ K +E+R
Sbjct: 555 VEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERL 614
Query: 104 REDQ--KRAA------VEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
E++ K+AA VE +RKQ+ EE RL + + ER Q L+KK
Sbjct: 615 AEEKAKKKAAAKKMEEVEARRKQE--EEARRLRWLQQEEEERRHQELLQKK 663
Score = 45.1 bits (105), Expect = 2e-04
Identities = 26/93 (27%), Positives = 45/93 (48%)
Query: 48 FLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQ 107
F + DE+ AKE R EK + +E+ + R Q E+ RW + EE+ +R +
Sbjct: 599 FAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQE 658
Query: 108 KRAAVEEKRKQKLREEEERLEAMMRRSLERTQQ 140
+E+ +++LR+ E +R ER +Q
Sbjct: 659 LLQKKKEEEQERLRKAAEAKRLAEQREQERREQ 691
Score = 41.2 bits (95), Expect = 0.003
Identities = 29/91 (31%), Positives = 53/91 (58%), Gaps = 16/91 (17%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKR 109
+ +E +RL ++EE E+ R Q++L+K+K ++ +ER RK E ++ +Q+
Sbjct: 637 QEEEARRLRWLQQEEEER----RHQELLQKKK-------EEEQERLRKAAEAKRLAEQRE 685
Query: 110 AAVEEKRKQKLREEEERLEAMMRRSLERTQQ 140
+E+R+Q+ RE+E R + RR ER +Q
Sbjct: 686 ---QERREQERREQERREQE--RREQERREQ 711
Score = 40.0 bits (92), Expect = 0.008
Identities = 26/112 (23%), Positives = 58/112 (51%), Gaps = 6/112 (5%)
Query: 43 QGMEGFLKSDE-----RQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRK 97
Q +E + +E RQ++ +++R E+ RE++ L K +AR + E+ EE+ ++
Sbjct: 536 QRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREER-LRKVLQARERVEQMKEEKKKQ 594
Query: 98 LEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
+E++ + D+K +E+R + + +++ M R +Q E ++ W
Sbjct: 595 IEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRW 646
Score = 37.7 bits (86), Expect = 0.038
Identities = 28/100 (28%), Positives = 56/100 (56%), Gaps = 8/100 (8%)
Query: 49 LKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQME-ERWRKLEEQRQREDQ 107
+K ++++++ ++ + EK A+E+++ E++ + + +K E E RK EE+ +R
Sbjct: 587 MKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRW 646
Query: 108 KRAAVEEKRKQKL-----REEEERLE--AMMRRSLERTQQ 140
+ EE+R Q+L EE+ERL A +R E+ +Q
Sbjct: 647 LQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQ 686
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 89.0 bits (219), Expect = 1e-17
Identities = 65/194 (33%), Positives = 114/194 (58%), Gaps = 40/194 (20%)
Query: 406 EKRRQARLQKEQEE-------QERVEKEEQDRLEREELKRKAEEER----LRLEEEARKQ 454
++RR+ RL++EQEE +E E+ EQ+R +++LKR EEER L+LEEE R++
Sbjct: 440 QERREQRLKREQEERRDWLKREEETERHEQER-RKQQLKRDQEEERRERWLKLEEEERRE 498
Query: 455 EEERK----------RQEEEKKKQEGEEK---RKAGEEAKRKAEEE----LLLKEKQ--- 494
++ER+ R+E+ K+QE EE+ R E+ R+ +EE LL +E++
Sbjct: 499 QQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRL 558
Query: 495 EQEKQEKAMIEKQKEAAE--TKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTR 552
EQE++E+ + +Q+E + K E Q RL+REQ +ERLE++ + +E+ + +
Sbjct: 559 EQERREQRLKREQEERRDQLLKREEERRQQRLKREQ------EERLEQRLKREEVERLEQ 612
Query: 553 KSDVPPQVKKEDPK 566
+ ++K+E+P+
Sbjct: 613 EERREQRLKREEPE 626
Score = 87.4 bits (215), Expect = 4e-17
Identities = 52/171 (30%), Positives = 111/171 (64%), Gaps = 16/171 (9%)
Query: 407 KRRQARLQKEQEEQERVEKEEQD---RLEREELKRKAEEE-----RLRLEEEAR-KQEEE 457
++ + +LQ+E+ +++R +EE++ +LER+EL+R+ +EE RLR E++ R KQEEE
Sbjct: 254 RKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEE 313
Query: 458 RKRQEEEKKKQ-----EGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAE 512
R+ Q+EE+++Q + EE+R+ +++ E L+ +QE+E++E+ + +Q+E E
Sbjct: 314 RREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEE--E 371
Query: 513 TKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKE 563
+ +++ + +L REQ + + +Q R E++ R ++ ++R ++ Q+++E
Sbjct: 372 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 422
Score = 86.7 bits (213), Expect = 7e-17
Identities = 54/178 (30%), Positives = 106/178 (59%), Gaps = 19/178 (10%)
Query: 406 EKRRQARLQKEQEEQERVEKEE-----------QDRLEREE-LKRKAEEERLRLEEEARK 453
E +RQ LQ+E+E+ ++E++E Q RL RE+ L+RK EEER +EE R+
Sbjct: 264 EPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERRE 323
Query: 454 QEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEE----ELLLKEKQEQEKQEKAMIEKQKE 509
Q+E R++QEE +++Q E+ + E+ R+ +E E L+ +QE+E++E+ + +Q+
Sbjct: 324 QQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQL 383
Query: 510 AAETKAR---EVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKED 564
E + R ++ + +L REQ + + +Q R E++ R ++ ++R ++ + Q +++
Sbjct: 384 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQE 441
Score = 84.3 bits (207), Expect = 4e-16
Identities = 53/169 (31%), Positives = 108/169 (63%), Gaps = 13/169 (7%)
Query: 408 RRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEER---LRLEEEARKQEEERKRQEEE 464
RR+ +L++EQEE+ +K EQ+R RE+ ++ +EER L+ EEE + E+ER++Q+ +
Sbjct: 420 RREQQLRREQEEERHEQKHEQER--REQRLKREQEERRDWLKREEETERHEQERRKQQLK 477
Query: 465 KKKQEGEEKR--KAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAE-Q 521
+ ++E +R K EE +R+ +E + ++EQE++ + +++Q+E + R +E Q
Sbjct: 478 RDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQ 537
Query: 522 MRLE----REQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKEDPK 566
+R E REQ++ + E++RLE+++R ++ +KR ++ +K+E+ +
Sbjct: 538 LRREQEERREQLLKREEEKRLEQERR-EQRLKREQEERRDQLLKREEER 585
Score = 83.6 bits (205), Expect = 6e-16
Identities = 52/164 (31%), Positives = 100/164 (60%), Gaps = 13/164 (7%)
Query: 406 EKRRQARLQKEQEE--QERVEKEEQDRLEREE-----LKRKAEEERLRLEEEARKQEEER 458
E+RRQ RL++EQEE ++R+++EE +RLE+EE LKR+ EE R + +++EER
Sbjct: 583 EERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEER 642
Query: 459 KRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREV 518
++Q+ +++QE E+R EE + + E+ L + ++E+ +QE A E+++ K+R
Sbjct: 643 RQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIP 702
Query: 519 AEQMRLERE------QIMLQIEQERLERKKRIDEIMKRTRKSDV 556
Q +LE E ++ + ++ +R+++ E +R R+S++
Sbjct: 703 KWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESEL 746
Score = 82.8 bits (203), Expect = 1e-15
Identities = 46/158 (29%), Positives = 98/158 (62%), Gaps = 7/158 (4%)
Query: 407 KRRQARLQKEQEEQERVEKEEQDRL-EREELKRKAEEERLRLEEEARKQEEERKRQEEEK 465
++R+ L+KE+E+ + E + Q L E EE RK E + LR E + +Q+++R R+E++
Sbjct: 247 RKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQL 306
Query: 466 KKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLE 525
++++ EE+R+ EE + + E + +Q++E++E+ + +Q+E E + R E+ R E
Sbjct: 307 RRKQEEERREQQEERREQQE-----RREQQEERREQQLRREQEERREQQLRREQEEERRE 361
Query: 526 REQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKE 563
+Q+ + E+ER E++ R ++ ++R ++ Q+++E
Sbjct: 362 -QQLRREQEEERREQQLRREQQLRREQQLRREQQLRRE 398
Score = 82.0 bits (201), Expect = 2e-15
Identities = 64/243 (26%), Positives = 124/243 (51%), Gaps = 27/243 (11%)
Query: 327 QDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAA 386
Q+ ++ E+E+ +E E L ++ + +E ++ DK +K G + E
Sbjct: 924 QEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRR 983
Query: 387 LGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKA-----E 441
+ + R + LQ+E+E+ R E+E++ R E E RK E
Sbjct: 984 QEREK--------------KYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE 1029
Query: 442 EERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEK 501
EE+L EE +++ +ER+RQ E+++ + EE++ GEE + + +EL + ++E+E Q++
Sbjct: 1030 EEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQE 1089
Query: 502 AMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVK 561
E+Q E + R E+ R RE+ LQ E+E+L R++R ++ R+ ++ Q +
Sbjct: 1090 ---EEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREER-----EKRRRQELERQYR 1141
Query: 562 KED 564
+E+
Sbjct: 1142 EEE 1144
Score = 81.3 bits (199), Expect = 3e-15
Identities = 55/169 (32%), Positives = 101/169 (59%), Gaps = 13/169 (7%)
Query: 407 KRRQARLQKEQEEQERVEKE-----EQDRLEREELKRKAEEERLRLEEEARKQEEERKRQ 461
++ Q LQ+E+EE +R E+E EQ+R REE + + EEE+L EE +++ +ER+RQ
Sbjct: 900 RKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQ 959
Query: 462 EEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQ 521
+ KK + +E++ GEE +++ +E +EK+ +E++E E+Q E + R E
Sbjct: 960 YRKDKKLQQKEEQLLGEEPEKRRRQE---REKKYREEEELQQEEEQLLREEREKRRRQEW 1016
Query: 522 MRLEREQIMLQIEQERL---ERKKRIDEIMKRTRKSDVPPQVKKEDPKV 567
R R++ LQ E+E+L ER+KR + +R R+ ++++E+ ++
Sbjct: 1017 ERQYRKKDELQQEEEQLLREEREKR--RLQERERQYREEEELQQEEEQL 1063
Score = 80.1 bits (196), Expect = 7e-15
Identities = 72/282 (25%), Positives = 144/282 (51%), Gaps = 35/282 (12%)
Query: 330 PKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGK 389
P+++ +E+ K RE QQ EE L + +K ++ K E L +
Sbjct: 978 PEKRRRQEREKKYREEEELQQE-----EEQLLREEREKRRRQEWERQYRKKDE----LQQ 1028
Query: 390 PTAGTTDAGEAAKILAEKRRQARLQKE-QEEQERVEKEEQDRLEREELKRK--------A 440
+ L E+ RQ R ++E Q+E+E++ EE++ R+EL+R+
Sbjct: 1029 EEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQ 1088
Query: 441 EEERLRLEEEARKQEEERKRQ--EEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEK 498
EEE+L EE +++ +ER+RQ EEE+ +QE E+ + E +R+ E E +E++E ++
Sbjct: 1089 EEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQ 1148
Query: 499 QEKAMI-----EKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKR----IDEIMK 549
+E+ ++ +++++ E + RE E+++ E EQ++ + +++R + ++R +E+ +
Sbjct: 1149 EEEQLLREEPEKRRRQELERQYRE-EEELQQEEEQLLREEQEKRRQERERQYREEEELQR 1207
Query: 550 RTRKSDVPPQVKKEDPKVGVQPAVCVEKKTKLVVPNKMEING 591
+ RK + ++ D K +P +K V NK+ G
Sbjct: 1208 QKRKQRYRDEDQRSDLKWQWEP-----EKENAVRDNKVYCKG 1244
Score = 79.3 bits (194), Expect = 1e-14
Identities = 49/150 (32%), Positives = 91/150 (60%), Gaps = 1/150 (0%)
Query: 406 EKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEK 465
++RRQ R ++ +EE+E ++EEQ E E +R+ E ER EEE +QEEE+ +EE +
Sbjct: 1100 KRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPE 1159
Query: 466 KKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLE 525
K++ E +R+ EE + + EEE LL+E+QE+ +QE+ +++E + + R+ + +
Sbjct: 1160 KRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQ 1219
Query: 526 REQIMLQIEQERLERKKRIDEIMKRTRKSD 555
R + Q E E+ E R +++ + R+++
Sbjct: 1220 RSDLKWQWEPEK-ENAVRDNKVYCKGRENE 1248
Score = 78.2 bits (191), Expect = 3e-14
Identities = 61/262 (23%), Positives = 132/262 (50%), Gaps = 39/262 (14%)
Query: 332 RKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPT 391
R+ ++E+ +++E QQ Q EE E+ + + + + E
Sbjct: 307 RRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQ---- 362
Query: 392 AGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAE----EERLRL 447
+ + E+RR+ +L++EQ+ + + + +L RE+ R+ + E++LR
Sbjct: 363 -------QLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 415
Query: 448 EEEARKQEEERKRQEEEKKKQEGEEKR----------------KAGEEAKRKAEE--ELL 489
E++ R++++ R+ QEEE+ +Q+ E++R K EE +R +E +
Sbjct: 416 EQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQ 475
Query: 490 LKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQ-----IMLQIEQERLERKKRI 544
LK QE+E++E+ + +++E E + R +Q+R E+E+ + Q E+ERL+++ R
Sbjct: 476 LKRDQEEERRERWLKLEEEERREQQERR-EQQLRREQEERREQRLKRQEEEERLQQRLRS 534
Query: 545 DEIMKRTRKSDVPPQVKKEDPK 566
++ ++R ++ +K+E+ K
Sbjct: 535 EQQLRREQEERREQLLKREEEK 556
Score = 77.8 bits (190), Expect = 3e-14
Identities = 74/254 (29%), Positives = 126/254 (49%), Gaps = 38/254 (14%)
Query: 326 GQDMPKRKAEKEKSNKEREGTLAQQAAGP---QGEEALEKHVVDKHASEKHAAAAGGKAE 382
G++ R+ E+++ +E E L +Q Q E+ L + +++ E+ + E
Sbjct: 1679 GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQE 1738
Query: 383 NSAALGKPTAGTTDAGEAAKILAEKRRQARLQKE-QEEQERVEKEEQDRLEREELKRK-A 440
+ RRQ R +K +EEQ R E+EEQ +L R+E RK
Sbjct: 1739 -----------------------QLRRQERYRKILEEEQLRPEREEQ-QLRRQERDRKFR 1774
Query: 441 EEERLRLEEE---ARKQEEERKRQEEEKKKQEGEEK--RKAGEEAKRKAEEELLLKEKQE 495
EEE+LR E E R QE +RK +EEE+ +QE EE+ R + K + EEE L E+QE
Sbjct: 1775 EEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQE 1834
Query: 496 Q---EKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTR 552
Q +++++ +++ A + K+R +++ E EQ Q E+ER R++ I K +
Sbjct: 1835 QRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQ-ERERKLREEHIRRQQKEEQ 1893
Query: 553 KSDVPPQVKKEDPK 566
+ ++K ++ K
Sbjct: 1894 RHRQVGEIKSQEGK 1907
Score = 77.4 bits (189), Expect = 4e-14
Identities = 58/279 (20%), Positives = 143/279 (51%), Gaps = 32/279 (11%)
Query: 324 LSGQDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAEN 383
L ++ RK E+++ +ER+ QQ + ++ K ++ ++ + E
Sbjct: 271 LQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQ 330
Query: 384 SAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQER---VEKEEQDRLEREELKRKA 440
+ + + E+RR+ +L++EQEE+ R + +E+++ ++L+R+
Sbjct: 331 QEERRE---------QQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQ 381
Query: 441 E---EERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQE 497
+ E++LR E++ R++++ R+ Q+ +++Q E++ E+ R+ +EE ++K EQE
Sbjct: 382 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQE 441
Query: 498 KQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQI----------------EQERLERK 541
++E+ + +Q+E + RE E R E+E+ Q+ E+ER E++
Sbjct: 442 RREQRLKREQEERRDWLKRE-EETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQ 500
Query: 542 KRIDEIMKRTRKSDVPPQVKKEDPKVGVQPAVCVEKKTK 580
+R ++ ++R ++ ++K+++ + +Q + E++ +
Sbjct: 501 ERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLR 539
Score = 77.0 bits (188), Expect = 6e-14
Identities = 56/190 (29%), Positives = 104/190 (54%), Gaps = 24/190 (12%)
Query: 399 EAAKILAEKRRQARLQKE----QEEQERVEKEEQDR-------LEREELKRK-------A 440
E + L + R +LQ+E QE+QER +EQ R LE E +R+ A
Sbjct: 835 EEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPA 894
Query: 441 EEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKE------KQ 494
+E+LR E++ ++EEE ++EE +K++ E++R+ EE + + EEE LL+E +Q
Sbjct: 895 LQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQ 954
Query: 495 EQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKS 554
E+E+Q + + Q++ + E ++ R ERE+ + E+ + E ++ + E ++ R+
Sbjct: 955 ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQ 1014
Query: 555 DVPPQVKKED 564
+ Q +K+D
Sbjct: 1015 EWERQYRKKD 1024
Score = 77.0 bits (188), Expect = 6e-14
Identities = 58/178 (32%), Positives = 102/178 (57%), Gaps = 13/178 (7%)
Query: 399 EAAKILAEKRRQARLQKEQEEQERVE---KEEQDRLEREELKRKAEEERLRLEEEARK-- 453
E + L + R+ R ++EQE Q R E ++E+++L REE +++ +ER R + +K
Sbjct: 908 EEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQ 967
Query: 454 QEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKE------KQEQEKQEKAMIEKQ 507
Q+EE+ EE +K++ E ++K EE + + EEE LL+E +QE E+Q + E Q
Sbjct: 968 QKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQ 1027
Query: 508 KEAAETKAREVAEQMRL-EREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKED 564
+E E RE E+ RL ERE+ + E+ + E ++ + E + R+ ++ Q +KE+
Sbjct: 1028 QE-EEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEE 1084
Score = 77.0 bits (188), Expect = 6e-14
Identities = 67/245 (27%), Positives = 126/245 (51%), Gaps = 31/245 (12%)
Query: 327 QDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAA 386
++ + E+++ E E L +Q + E+ L +H D+ E+ G+ +
Sbjct: 1632 EEQQLHRQERDRKFLEEEPQLRRQ----EREQQL-RHDRDRKFREEEQLLQEGEEQQ--- 1683
Query: 387 LGKPTAGTTDAGEAAKILAEKRRQARLQKEQ------------EEQERVEKEEQDRLERE 434
L + E ++ ++R + LQ+EQ EE++ ++ EQ++L R+
Sbjct: 1684 LRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQ 1743
Query: 435 ELKRK-AEEERLRLEEE---ARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLL 490
E RK EEE+LR E E R+QE +RK +EEE+ +QE EE++ +E+ RK EE
Sbjct: 1744 ERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREE--- 1800
Query: 491 KEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKR 550
E+ QE++E+ + +Q++ K R EQ++LE ++ L+ E++R R + ++
Sbjct: 1801 -EQLRQEREEQQLRPQQRDG---KYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEK 1856
Query: 551 TRKSD 555
+R+ +
Sbjct: 1857 SRREE 1861
Score = 76.3 bits (186), Expect = 1e-13
Identities = 64/239 (26%), Positives = 121/239 (50%), Gaps = 23/239 (9%)
Query: 327 QDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAA 386
+D KR+ E E+ +ER QQ Q EE E+ + + + +
Sbjct: 455 RDWLKREEETERHEQERR---KQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQ 511
Query: 387 LGKPTAGTTDAGEAAKILAEKRRQARLQKEQEE--QERVEKEEQDRLEREE----LKRKA 440
+ E ++ R + +L++EQEE ++ +++EE+ RLE+E LKR+
Sbjct: 512 EERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQ 571
Query: 441 EEER---LRLEEEARKQ-----EEER-----KRQEEEKKKQEGEEKRKAGEEAKRKAEEE 487
EE R L+ EEE R+Q +EER KR+E E+ +QE +++ E + +
Sbjct: 572 EERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQ 631
Query: 488 LLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDE 546
LLK ++++E++++ + +Q+E E + + E+ RLE +++ + E+ER E++ +E
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLE-QRLKREHEEERREQELAEEE 689
Score = 76.3 bits (186), Expect = 1e-13
Identities = 59/240 (24%), Positives = 115/240 (47%), Gaps = 33/240 (13%)
Query: 327 QDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAA 386
Q+ +R+ E+E+ + RE L Q +E H + ++ +AE +
Sbjct: 726 QEGQRRRQEQEEKRRRRESEL-------QWQEEERAHRQQQEEEQRRDFTWQWQAEEKSE 778
Query: 387 LGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLR 446
G+ + ++ RQ R ++ Q+ ++R EE+++ +R +R+ E+E
Sbjct: 779 RGRQRLSARPP-----LREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQF 833
Query: 447 LEEEARKQEEERKRQ--EEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMI 504
LEEE + Q ER +Q EEE QE +E+R++ +E++ +K +
Sbjct: 834 LEEEEQLQRRERAQQLQEEEDGLQEDQERRRS--------------QEQRRDQKWRWQLE 879
Query: 505 EKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKED 564
E++K T + A Q +L +EQ +LQ E+E L+R++R ++ R+ + Q ++E+
Sbjct: 880 EERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREER-----EKRRRQEQERQYREEE 934
Score = 75.5 bits (184), Expect = 2e-13
Identities = 54/177 (30%), Positives = 108/177 (61%), Gaps = 18/177 (10%)
Query: 406 EKRRQARLQKEQEE---QERVEKEEQDRLEREELKRKA--EEERLRLEEEARKQ-----E 455
E+RR+ RL++++EE Q+R+ E+Q R E+EE + + EE RLE+E R+Q +
Sbjct: 512 EERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQ 571
Query: 456 EERK----RQEEEKKKQ--EGEEKRKAGEEAKRKAEEELLLKEKQEQE-KQEKAMIEKQK 508
EER+ ++EEE+++Q + E++ + + KR+ E L +E++EQ K+E+ E+++
Sbjct: 572 EERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQ 631
Query: 509 EAAETKAREVAEQMRLEREQIMLQIEQ-ERLERKKRIDEIMKRTRKSDVPPQVKKED 564
+ +++ +E Q +L REQ + ++ +R E ++R+++ +KR + + Q E+
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEE 688
Score = 74.7 bits (182), Expect = 3e-13
Identities = 52/182 (28%), Positives = 105/182 (57%), Gaps = 23/182 (12%)
Query: 406 EKRRQARLQKEQEEQERVEKEEQDRLEREE-------LKRKAEEERL----RLEEEARKQ 454
E+RR+ L+ E+EE+ ++ + +L RE+ LKR+ EEERL R E++ R++
Sbjct: 482 EERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRRE 541
Query: 455 EEER-----KRQEEEKKKQEGEEKRKAGEEAKRKAE----EELLLKEKQEQEKQEKAMIE 505
+EER KR+EE++ +QE E+R E+ +R+ + EE +++ ++E++E+
Sbjct: 542 QEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQR 601
Query: 506 KQKEAAETKAREVAEQMRLEREQIMLQIEQERL---ERKKRIDEIMKRTRKSDVPPQVKK 562
++E E +E + RL+RE+ + Q+ L E+++R + ++R ++ ++K+
Sbjct: 602 LKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKR 661
Query: 563 ED 564
E+
Sbjct: 662 EE 663
Score = 74.7 bits (182), Expect = 3e-13
Identities = 60/244 (24%), Positives = 123/244 (50%), Gaps = 48/244 (19%)
Query: 325 SGQDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENS 384
S QD+ E+++ ++E+E QQ ++H ++ E+ + +
Sbjct: 1263 SQQDLQHLLGEQQERDREQERRRWQQR---------DRHFPEEEQLEREEQKEAKRRDRK 1313
Query: 385 AALGKPTAGTTDAGEAAKILAEKRRQARLQKE-----QEEQERVEKEEQDRLEREELKRK 439
+ E ++L E+R + R ++E +EE++ +++ E+ L R+E RK
Sbjct: 1314 SQ------------EEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRK 1361
Query: 440 AEEERLRLEEEARK--QEEERKRQEEEKKK----------QEGEEKRKAGEEAK-RKAEE 486
EE LR +E+ RK +EE+R R++E ++K QE E++ + + K R+ E+
Sbjct: 1362 FREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQ 1421
Query: 487 ELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLER-------EQIMLQIEQERLE 539
+L +E+ + ++E+ + +Q+ E K E +Q+R ER EQ++ + E+++L
Sbjct: 1422 QLSRQERDRKFREEEQQVRRQER--ERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLH 1479
Query: 540 RKKR 543
R++R
Sbjct: 1480 RQER 1483
Score = 74.7 bits (182), Expect = 3e-13
Identities = 49/149 (32%), Positives = 95/149 (63%), Gaps = 13/149 (8%)
Query: 408 RRQARLQKEQEEQER-VEKEEQDRLEREE--LKRKAEEERLRLEEE-ARKQEEERKRQEE 463
RRQ R Q+ +++++R +EEQ R EREE L R+ + + RLEE+ R+QE+ERK E+
Sbjct: 1541 RRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMED 1600
Query: 464 EKKKQEGEEKRKAGEEAKRK-AEEELLLKEKQEQ----EKQEKAMIEKQ----KEAAETK 514
E++ + E +++ +E RK E+E LL+E++EQ +++++ +E++ ++ E +
Sbjct: 1601 EQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQ 1660
Query: 515 AREVAEQMRLEREQIMLQIEQERLERKKR 543
R ++ E EQ++ + E+++L R++R
Sbjct: 1661 LRHDRDRKFREEEQLLQEGEEQQLRRQER 1689
Score = 74.3 bits (181), Expect = 4e-13
Identities = 47/169 (27%), Positives = 100/169 (59%), Gaps = 10/169 (5%)
Query: 408 RRQARLQKEQEE---QERVEK--EEQDRLEREELKRKAEEERLRLE--EEARKQEEERKR 460
R + +LQ+E+E+ +ER ++ +E++R R++ K + +EE+L E E+ R+QE E+K
Sbjct: 931 REEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY 990
Query: 461 QEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMI--EKQKEAAETKAREV 518
+EEE+ +QE E+ + E +R+ E E ++K E +++E+ ++ E++K + + R+
Sbjct: 991 REEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQY 1050
Query: 519 AEQMRLEREQIMLQIEQERLERKKRID-EIMKRTRKSDVPPQVKKEDPK 566
E+ L++E+ L E+ R++ ++ + K Q+ +E+P+
Sbjct: 1051 REEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPE 1099
Score = 73.9 bits (180), Expect = 5e-13
Identities = 47/158 (29%), Positives = 91/158 (57%), Gaps = 11/158 (6%)
Query: 399 EAAKILAEKRRQARLQKEQEEQER----VEKEEQDRLEREELKRKAEE---ERLRLEEEA 451
E ++ E+RR+ RL++E+ E+ER ++ EEQ+ +++L+R+ +E +RL+ EEE
Sbjct: 606 EVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEE 665
Query: 452 RKQEEERKRQ-EEEKKKQE--GEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQK 508
+ E+ KR+ EEE+++QE EE+ +A E K + + E + +Q K +K
Sbjct: 666 ERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRK 725
Query: 509 EAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDE 546
+ + + +E E+ R ++ Q E+ER R+++ +E
Sbjct: 726 QEGQRRRQEQEEKRRRRESELQWQ-EEERAHRQQQEEE 762
Score = 73.9 bits (180), Expect = 5e-13
Identities = 65/241 (26%), Positives = 121/241 (50%), Gaps = 11/241 (4%)
Query: 331 KRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKP 390
+R+ E ++ +E E L ++ P + ++ ++ +H E L +
Sbjct: 1329 RRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEEL--RHQEQGRKFLEEEQRLRRQ 1386
Query: 391 TAGTTDAGEAAKILAEKR----RQARLQKEQEEQERVEKEEQDRLEREELK--RKAEEER 444
E ++ ++R RQ R +K +EE++++ ++E+DR REE + R+ E ER
Sbjct: 1387 ERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERER 1446
Query: 445 LRLEEEAR-KQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAM 503
LEEE + +QE RK +EEE+ QE EE++ +E RK EE +QE++++ +
Sbjct: 1447 KFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQ 1506
Query: 504 IEKQKEAAETKAREVAEQM-RLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKK 562
E + + E K E +Q+ R +R++ LQ EQ+ +++ R RK Q+++
Sbjct: 1507 -ELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQ 1565
Query: 563 E 563
E
Sbjct: 1566 E 1566
Score = 72.8 bits (177), Expect = 1e-12
Identities = 57/161 (35%), Positives = 99/161 (61%), Gaps = 15/161 (9%)
Query: 407 KRRQARLQKEQEEQERVEKEEQD-RLEREELKRKAEEERLRLEEEARKQEEERKRQEEEK 465
KRR+ L + QE++ KE+Q + E EEL+R+ E+R R E+E + +EEE+ +QEEE+
Sbjct: 883 KRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQ 942
Query: 466 KKQEGEEKRKAGEEAKRKAEEELLLKEKQEQ---EKQEKAMIEKQKEAAETKAREVAEQM 522
+E EKR+ +E +R+ ++ L++K+EQ E+ EK ++++ E K RE E++
Sbjct: 943 LLREEREKRRR-QERERQYRKDKKLQQKEEQLLGEEPEK----RRRQEREKKYRE-EEEL 996
Query: 523 RLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKE 563
+ E EQ+ L+ E+E K+R E ++ RK D Q +++
Sbjct: 997 QQEEEQL-LREERE----KRRRQEWERQYRKKDELQQEEEQ 1032
Score = 71.2 bits (173), Expect = 3e-12
Identities = 62/259 (23%), Positives = 124/259 (47%), Gaps = 23/259 (8%)
Query: 327 QDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAA 386
++ KR+ E+E+ +E E Q+ +E + + EK A K
Sbjct: 1186 EEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGR 1245
Query: 387 LGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLR 446
+ D+ L +++ Q LQ EQ+ ++E++ R ++ + EEE+L
Sbjct: 1246 ENEQFRQLEDSQ-----LRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLE 1300
Query: 447 LEEEARKQEEERKRQEEEK-KKQEGEEKRKAGEEAKRKAEEELLLKEKQEQ----EKQEK 501
EE+ + +RK QEE++ ++E EEKR+ E ++ EEE LL+E++EQ +++++
Sbjct: 1301 REEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDR 1360
Query: 502 AMIEKQKEAAETKAREVAEQMRL---EREQIMLQIEQE----------RLERKKRIDEIM 548
E++ E + + E+ RL ERE+ L+ EQ+ R +R ++ E
Sbjct: 1361 KFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEE 1420
Query: 549 KRTRKSDVPPQVKKEDPKV 567
++ + + + ++E+ +V
Sbjct: 1421 QQLSRQERDRKFREEEQQV 1439
Score = 70.9 bits (172), Expect = 4e-12
Identities = 70/273 (25%), Positives = 126/273 (46%), Gaps = 38/273 (13%)
Query: 318 KYRLPALSGQDMPKRKAEKEKS--NKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAA 375
K+R L Q+ ++ E+E+ +ERE ++ + +E ++ D+ +
Sbjct: 1361 KFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEE 1420
Query: 376 AAGGKAENSAALGKPTAGTTDAGEAAKILAEKR--RQARLQKEQEEQERVEKEEQDRLER 433
+ E + K L E++ RQ R +K +EE++ +++ E+ +L R
Sbjct: 1421 QQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHR 1480
Query: 434 EELKRKAEEERLRL----------EEEARKQEEERKRQEEEKKKQEGEEKRKAGEEA--- 480
+E RK EE +L E+E R QE ERK EEE++ + +RK +E
Sbjct: 1481 QERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQL 1540
Query: 481 --------------KRKAEEELLLKEKQE-----QEKQEKAMIEKQKEAAETKAREVAE- 520
++ EEE L +E++E QE+ K +E+QK + + R+ E
Sbjct: 1541 RRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMED 1600
Query: 521 QMRLEREQIMLQIEQERLERKKRIDEIMKRTRK 553
+ +L R++ Q+ QER +RK R DE + + R+
Sbjct: 1601 EQQLRRQEGQQQLRQER-DRKFREDEQLLQERE 1632
Score = 68.9 bits (167), Expect = 2e-11
Identities = 58/251 (23%), Positives = 125/251 (49%), Gaps = 16/251 (6%)
Query: 327 QDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAA 386
+ + + + E++ S +ER+ + + +E K + D+ + + E
Sbjct: 1561 EQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRK 1620
Query: 387 LGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLER-------EELKRK 439
+ + E L + R + +E+ + R E+E+Q R +R E+L ++
Sbjct: 1621 FREDEQLLQEREEQQ--LHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQE 1678
Query: 440 AEEERLRLEEEARK---QEEERKRQEEEKK-KQEGEEKRKAGEEAKRKAEEELLLKEKQE 495
EE++LR +E RK +E++ +RQE E+K QE ++ R+ E K + EE+L + +QE
Sbjct: 1679 GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQE 1738
Query: 496 Q---EKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTR 552
Q +++ + ++E+++ E + +++ Q R + + Q+ QER E++ R E ++ R
Sbjct: 1739 QLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFR 1798
Query: 553 KSDVPPQVKKE 563
+ + Q ++E
Sbjct: 1799 EEEQLRQEREE 1809
Score = 68.6 bits (166), Expect = 2e-11
Identities = 57/236 (24%), Positives = 116/236 (49%), Gaps = 21/236 (8%)
Query: 327 QDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGG------K 380
++ +R+ +KE ++R+ +Q + EE + D+ E+ +
Sbjct: 1296 EEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRR 1355
Query: 381 AENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKE-----QEEQERVEKEEQDRLEREE 435
E + + G K L E++R R ++E +E+Q R ++ EQ + +
Sbjct: 1356 QERDRKFREEELRHQEQGR--KFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRD 1413
Query: 436 LKRKAEEERLRLEEEARK--QEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEK 493
K + EE++L +E RK +EE++ R++E ++K EE++ E ++ EEE LL+E+
Sbjct: 1414 RKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQER 1473
Query: 494 QE-----QEKQEKAMIEKQKEAAETKAREVAEQ-MRLEREQIMLQIEQERLERKKR 543
+E QE+ K + E+Q+ + + R+ EQ +R + + E+++L R++R
Sbjct: 1474 EEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQR 1529
Score = 68.6 bits (166), Expect = 2e-11
Identities = 55/160 (34%), Positives = 94/160 (58%), Gaps = 17/160 (10%)
Query: 408 RRQARLQK--EQEEQERVEK------EEQDRLEREELK-RKAEEERLRLEEE--ARKQEE 456
RRQ R +K E+E+Q R E+ EEQ EREE + + E +R LEEE R+QE
Sbjct: 1440 RRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQER 1499
Query: 457 ERKRQEEEKKKQEGEEK-RKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKA 515
+RK +E+E + QE E K + ++ R+ + L+E+Q+ +QE+ +++++ + K
Sbjct: 1500 DRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERG--QQRRQDRDRKF 1557
Query: 516 REVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSD 555
RE EQ+R ERE+ Q+ ++ +RK R++E R ++ +
Sbjct: 1558 RE-EEQLRQEREE--QQLSRQERDRKFRLEEQKVRRQEQE 1594
Score = 67.4 bits (163), Expect = 5e-11
Identities = 58/197 (29%), Positives = 100/197 (50%), Gaps = 39/197 (19%)
Query: 406 EKRRQARLQKEQEEQERVEKEEQDRLEREELKRKA--------EEERLRLEEE-ARKQEE 456
EKRR+ L+++ E+E V++EE+ L E KR+ EEE L+ EEE ++E+
Sbjct: 1129 EKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQ 1188
Query: 457 ERKRQEEEKKKQEGEE-KRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEK--------- 506
E++RQE E++ +E EE +R+ ++ R ++ LK + E EK+ K
Sbjct: 1189 EKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENE 1248
Query: 507 ---QKEAAETKARE--------VAEQMRLEREQIMLQ--------IEQERLERKKRIDEI 547
Q E ++ + R+ + EQ +REQ + E+E+LER+++ E
Sbjct: 1249 QFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ-KEA 1307
Query: 548 MKRTRKSDVPPQVKKED 564
+R RKS Q+ +E+
Sbjct: 1308 KRRDRKSQEEKQLLREE 1324
Score = 66.2 bits (160), Expect = 1e-10
Identities = 48/171 (28%), Positives = 97/171 (56%), Gaps = 15/171 (8%)
Query: 406 EKRRQARLQKEQEEQERVEK-EEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEE 464
++RRQ R ++E+E E E+ E+Q+RLE+ + +R+ EE L + + ++ EER+ +EE+
Sbjct: 135 QRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEE--LWRQRQEWQEREERRAEEEQ 192
Query: 465 KKKQEGEEKRKAGEEAKRKAEEELLLK-----EKQEQEKQEKAMIEKQKEAAETKAREVA 519
+ +G E + +E + + E L L+ EKQ+Q ++ + + +++E E + RE
Sbjct: 193 LQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETV 252
Query: 520 ---EQMRLERE----QIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKE 563
E+ +L+ E Q LQ E+E+L + +R + +R + ++++E
Sbjct: 253 LRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRRE 303
Score = 65.9 bits (159), Expect = 1e-10
Identities = 54/158 (34%), Positives = 93/158 (58%), Gaps = 18/158 (11%)
Query: 407 KRRQARLQKE-----QEEQERVEKEEQDRLEREE--LKRKAEEERLRLEEEARK-QEEER 458
KRR + Q+E +E +E+ ++E DR REE L ++ EE+ LR +E RK +EEE
Sbjct: 1308 KRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEEL 1367
Query: 459 KRQEEEKKKQEGEEKRKAGEEAKR--KAEEELLLKEKQEQEKQE---KAMIEKQ---KEA 510
+ QE+ +K E E++ + E ++ K E++L +E+++Q +Q+ K E+Q ++
Sbjct: 1368 RHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQE 1427
Query: 511 AETKAREVAEQM-RLEREQIMLQIEQE-RLERKKRIDE 546
+ K RE +Q+ R ERE+ L+ EQ+ R ER ++ E
Sbjct: 1428 RDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFRE 1465
Score = 63.9 bits (154), Expect = 5e-10
Identities = 44/111 (39%), Positives = 69/111 (62%), Gaps = 7/111 (6%)
Query: 43 QGMEGFLKSDERQRLAKERREE-REKCLAAREQQILEKQKRARL-QYEKQMEERWRKLEE 100
Q E L+ ERQ L +ER+EE +++ REQQ+ KQ+ R Q E++ E++ R+ ++
Sbjct: 272 QEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQ 331
Query: 101 QRQREDQKRAAVEEKRKQKLR--EEEERLEAMMRRSLE---RTQQLELKKK 146
+ +RE Q R EE+R+Q+LR +EEER E +RR E R QQL +++
Sbjct: 332 EERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382
Score = 63.5 bits (153), Expect = 7e-10
Identities = 49/176 (27%), Positives = 98/176 (55%), Gaps = 24/176 (13%)
Query: 399 EAAKILAEKRRQARLQKEQEEQERVEKEE------QDRLEREELKRKAEEERLRL----- 447
E + LAE Q+ Q+ E+++R ++E Q+ EREE R+AEEE+L+
Sbjct: 143 EQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREE--RRAEEEQLQSCKGHE 200
Query: 448 ------EEEARKQE--EERKRQEEEKKKQEGEEKRKA--GEEAKRKAEEELLLKEKQEQE 497
EE+ R++E E R++ EEK++Q E + + EE K + E +L++++E+
Sbjct: 201 TEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKL 260
Query: 498 KQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRK 553
++E+ +++ + E + R++ E+ L RE+ + +Q+RL R++++ + R+
Sbjct: 261 QEEEPQRQRELQEEEEQLRKL-ERQELRRERQEEEQQQQRLRREQQLRRKQEEERR 315
Score = 63.2 bits (152), Expect = 9e-10
Identities = 51/181 (28%), Positives = 103/181 (56%), Gaps = 25/181 (13%)
Query: 399 EAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEE--EARKQEE 456
E ++ E+ Q ++E++ + R+E E++ R + +E K +E++LR +E + +QE
Sbjct: 1559 EEEQLRQEREEQQLSRQERDRKFRLE-EQKVRRQEQERKFMEDEQQLRRQEGQQQLRQER 1617
Query: 457 ERKRQEEEKKKQEGEEKRKAGEEAKRK--AEEELLLKEKQEQE---------KQEKAMIE 505
+RK +E+E+ QE EE++ +E RK EE L ++++EQ+ ++E+ +++
Sbjct: 1618 DRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQ 1677
Query: 506 K------QKEAAETKAREVAEQM-RLEREQIMLQIEQ----ERLERKKRIDEIMKRTRKS 554
+ +++ + K RE +Q+ R ERE+ LQ EQ + LERK R +E +++ +
Sbjct: 1678 EGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQ 1737
Query: 555 D 555
+
Sbjct: 1738 E 1738
Score = 62.8 bits (151), Expect = 1e-09
Identities = 42/162 (25%), Positives = 87/162 (53%), Gaps = 12/162 (7%)
Query: 406 EKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLR------LEEEARKQEEERK 459
E+ + R + ++ E+ R E+E+ + E + +EE+LR L + R+++++++
Sbjct: 171 EELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQR 230
Query: 460 RQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQE-----QEKQEKAMIEKQKEAAETK 514
R+ +++ QE EEK E + EEE L +E+ + QE++E+ +++E +
Sbjct: 231 RERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRER 290
Query: 515 AREVAEQMRLERE-QIMLQIEQERLERKKRIDEIMKRTRKSD 555
E +Q RL RE Q+ + E+ER E+++ E +R + +
Sbjct: 291 QEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQE 332
Score = 60.8 bits (146), Expect = 4e-09
Identities = 47/181 (25%), Positives = 92/181 (50%), Gaps = 15/181 (8%)
Query: 398 GEAAKILAEKR-----RQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEAR 452
G+A + EKR +++ LQ ++E+++ E +DR EE ++ ++R E E
Sbjct: 90 GQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELA 149
Query: 453 KQEEERKRQE--EEKKKQEGEE-----KRKAGEEAKRKAEEELLLK---EKQEQEKQEKA 502
+ EE+ ++QE E++ +Q +E +++ E +R+AEEE L + E+ E+
Sbjct: 150 EGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQ 209
Query: 503 MIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKK 562
+ ++ K RE +Q R ER+ + Q E+E+ RK+ + + + PQ ++
Sbjct: 210 LRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQR 269
Query: 563 E 563
E
Sbjct: 270 E 270
Score = 59.7 bits (143), Expect = 9e-09
Identities = 53/237 (22%), Positives = 112/237 (47%), Gaps = 22/237 (9%)
Query: 320 RLPALSGQDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAA-AG 378
R L ++ +R+ +++ +E++ Q+ + EE LE+ + +H E+ A
Sbjct: 630 RQQLLKSEEQEERR--QQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAE 687
Query: 379 GKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKR 438
+ E + K ++ A + + ++QE Q R +++E+ R RE +
Sbjct: 688 EEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQ 747
Query: 439 KAEEERLRLEEEARKQEEERKRQ-----EEEKKKQEGEEKRKAGEEAKRKAEEELLLKEK 493
EEER ++ QEEE++R + E+K + G ++ A + + E +L +E+
Sbjct: 748 WQEEERAHRQQ----QEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEER 803
Query: 494 QEQEKQEKAMIEKQKEAAETKAREVAEQMRLERE-QIMLQIEQERLERKKRIDEIMK 549
Q++E Q+ E + +E + R ERE ++ E+E+L+R++R ++ +
Sbjct: 804 QQRE---------QRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQE 851
Score = 59.7 bits (143), Expect = 9e-09
Identities = 65/263 (24%), Positives = 125/263 (47%), Gaps = 36/263 (13%)
Query: 327 QDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHA--SEKHAAAAGGKAENS 384
+D R+ E++ S +ER+ ++ + +E K + ++ E+H E
Sbjct: 1412 RDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFR----EEE 1467
Query: 385 AALGKPTAGTTDAGEAAKILAEKRRQARLQ------KEQE----EQERVEKEEQDRLERE 434
L + E + E+ +Q R Q +EQE E ER EE+ +L R+
Sbjct: 1468 QLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQ 1527
Query: 435 ELKRK--AEEERLRLEEEARKQ---------EEERKRQEEEKK---KQEGEEKRKAGEEA 480
+ +RK EE++LR +E +++ EEE+ RQE E++ +QE + K + E+
Sbjct: 1528 QRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQK 1587
Query: 481 KRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLER 540
R+ E+E E ++Q ++++ ++ ++ + K RE EQ+ ERE+ L R ER
Sbjct: 1588 VRRQEQERKFMEDEQQLRRQEGQ-QQLRQERDRKFRE-DEQLLQEREEQQL----HRQER 1641
Query: 541 KKRIDEIMKRTRKSDVPPQVKKE 563
++ E + R+ + Q++ +
Sbjct: 1642 DRKFLEEEPQLRRQEREQQLRHD 1664
Score = 59.3 bits (142), Expect = 1e-08
Identities = 52/246 (21%), Positives = 117/246 (47%), Gaps = 9/246 (3%)
Query: 327 QDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAA 386
Q++ ++ E+E+ +E E L ++ + E + ++ +K + + S
Sbjct: 1164 QELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDL 1223
Query: 387 LGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQD--RLEREELKRKAEEER 444
+ +A K+ + R + ++ ++ Q R + +QD L E+ +R E+ER
Sbjct: 1224 KWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQER 1283
Query: 445 LRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMI 504
R ++ R EE + + EE+K E KR+ + K + E++LL +E++E+ ++++
Sbjct: 1284 RRWQQRDRHFPEEEQLEREEQK----EAKRR---DRKSQEEKQLLREEREEKRRRQETDR 1336
Query: 505 EKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKED 564
+ ++E + RE R ER++ + E E+ ++ E +R R+ + + KE+
Sbjct: 1337 KFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEE 1396
Query: 565 PKVGVQ 570
++ Q
Sbjct: 1397 QQLRCQ 1402
Score = 57.8 bits (138), Expect = 4e-08
Identities = 40/116 (34%), Positives = 65/116 (56%), Gaps = 15/116 (12%)
Query: 46 EGFLKSDERQRLAKERREEREKC--------LAARE----QQILEKQKRARLQYEKQMEE 93
E LK +E +RL +ERRE+R K L RE QQ L++++ RL+ + EE
Sbjct: 547 EQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREE 606
Query: 94 RWRKLEEQRQREDQKRAAVEEKRKQKL---REEEERLEAMMRRSLERTQQLELKKK 146
R +E+R+ + KR EE+R+Q+L E+EER + +RR + ++ LK++
Sbjct: 607 VERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKRE 662
Score = 57.0 bits (136), Expect = 6e-08
Identities = 32/91 (35%), Positives = 54/91 (59%), Gaps = 3/91 (3%)
Query: 52 DERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAA 111
DE Q +E E R K ++QQ E+Q R ++++ E+ WRK E ++E++K
Sbjct: 206 DEEQLRRRELLELRRKGREEKQQQRRERQDRV---FQEEEEKEWRKRETVLRKEEEKLQE 262
Query: 112 VEEKRKQKLREEEERLEAMMRRSLERTQQLE 142
E +R+++L+EEEE+L + R+ L R +Q E
Sbjct: 263 EEPQRQRELQEEEEQLRKLERQELRRERQEE 293
Score = 57.0 bits (136), Expect = 6e-08
Identities = 35/109 (32%), Positives = 61/109 (55%), Gaps = 12/109 (11%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEE----RWRKLEEQRQRE 105
+ + R++ K +EER L E+ +Q+R + Q ++ EE RW KLEE+ +RE
Sbjct: 439 EQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERRE 498
Query: 106 DQKRAAV------EEKRKQKLR--EEEERLEAMMRRSLERTQQLELKKK 146
Q+R EE+R+Q+L+ EEEERL+ +R + ++ E +++
Sbjct: 499 QQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERRE 547
Score = 56.6 bits (135), Expect = 8e-08
Identities = 40/119 (33%), Positives = 69/119 (57%), Gaps = 5/119 (4%)
Query: 33 VRTSQPNYRPQGMEGFLKSDER--QRLAKERREEREKCLAAREQQILEKQKRARLQYEKQ 90
+R Q R Q E + +ER Q+ +E++EER + REQ+ +Q+ R Q E++
Sbjct: 300 LRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEER 359
Query: 91 MEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEE-RLEAMMRR--SLERTQQLELKKK 146
E++ R+ +E+ +RE Q R + +R+Q+LR E++ R E +RR L R QQL +++
Sbjct: 360 REQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 418
Score = 56.6 bits (135), Expect = 8e-08
Identities = 37/113 (32%), Positives = 60/113 (53%), Gaps = 3/113 (2%)
Query: 34 RTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEE 93
R Q R Q + + QRL ++ EER + EQQ+ +Q+ R Q K+ EE
Sbjct: 496 RREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEE 555
Query: 94 RWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
+ +LE++R+ + KR EE+R Q L+ EEER + ++R E + LK++
Sbjct: 556 K--RLEQERREQRLKREQ-EERRDQLLKREEERRQQRLKREQEERLEQRLKRE 605
Score = 56.6 bits (135), Expect = 8e-08
Identities = 50/170 (29%), Positives = 96/170 (56%), Gaps = 15/170 (8%)
Query: 402 KILAEKR---RQARLQKEQEEQERVEKEEQDRLEREELKRK-AEEERLRLEEEARKQEEE 457
K L E++ RQ R +K +E++++ ++E+ + R++ RK EEE+LR E +EE+
Sbjct: 1516 KFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQE-----REEQ 1570
Query: 458 RKRQEEEKKKQEGEEKRKAGEEAKRK---AEEELLLKEKQEQEKQEKAMIEKQKEAAETK 514
+ ++E +K EE++ +E +RK E++L +E Q+Q +QE+ ++ E +
Sbjct: 1571 QLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQL-LQ 1629
Query: 515 AREVAEQMRLEREQIMLQIEQERLERKKRIDEIM-KRTRKSDVPPQVKKE 563
RE + R ER++ L+ E+ +L R++R ++ R RK Q+ +E
Sbjct: 1630 EREEQQLHRQERDRKFLE-EEPQLRRQEREQQLRHDRDRKFREEEQLLQE 1678
Score = 56.2 bits (134), Expect = 1e-07
Identities = 39/118 (33%), Positives = 73/118 (61%), Gaps = 10/118 (8%)
Query: 33 VRTSQPNYRPQGMEGFLKSDERQRLAKERREERE--KCLAAREQQILEKQKRARLQYEKQ 90
+R Q R Q ++ + +E +RL + R E++ + R +Q+L++++ RL+ E++
Sbjct: 507 LRREQEERREQRLK---RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERR 563
Query: 91 MEERWRKLEEQRQREDQKRAAVEEKRKQKL-REEEERLEAMMRR-SLERTQQLELKKK 146
E+R ++ EQ +R DQ EE+R+Q+L RE+EERLE ++R +ER +Q E +++
Sbjct: 564 -EQRLKR--EQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQ 618
Score = 55.1 bits (131), Expect = 2e-07
Identities = 39/111 (35%), Positives = 67/111 (60%), Gaps = 14/111 (12%)
Query: 49 LKSDERQRLAKERREEREKCLAAREQQIL-----EKQKRARLQYEKQM----EERWRKLE 99
L+ +E QR +E +EE E+ Q++ E+Q++ RL+ E+Q+ EE R+ +
Sbjct: 260 LQEEEPQR-QRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQ 318
Query: 100 EQRQREDQKRAAVEEKRKQKL-REEEERLEAMMRRSLE---RTQQLELKKK 146
E+R+ + ++R EE+R+Q+L RE+EER E +RR E R QQL +++
Sbjct: 319 EERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQE 369
Score = 55.1 bits (131), Expect = 2e-07
Identities = 38/103 (36%), Positives = 64/103 (62%), Gaps = 11/103 (10%)
Query: 49 LKSDE---RQRLAKERREEREKCLAAREQQILEKQKRA--RLQYEKQMEERWRKL----E 99
LK +E +QRL +E+ E E+ L E + LE+++R RL+ E+ EER ++L E
Sbjct: 579 LKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEE 638
Query: 100 EQRQREDQKRAAVEEKRKQKLR--EEEERLEAMMRRSLERTQQ 140
++ +R+ Q R +E+R+Q+L+ EEEERLE ++R E ++
Sbjct: 639 QEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERR 681
Score = 54.7 bits (130), Expect = 3e-07
Identities = 38/103 (36%), Positives = 57/103 (55%), Gaps = 2/103 (1%)
Query: 41 RPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEE 100
R Q ++ + + R+R K EER + REQQ+ +Q+ R Q K+ EE R L++
Sbjct: 472 RKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEER-LQQ 530
Query: 101 QRQREDQKRAAVEEKRKQKL-REEEERLEAMMRRSLERTQQLE 142
+ + E Q R EE+R+Q L REEE+RLE R + +Q E
Sbjct: 531 RLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEE 573
Score = 54.3 bits (129), Expect = 4e-07
Identities = 39/118 (33%), Positives = 68/118 (57%), Gaps = 6/118 (5%)
Query: 34 RTSQPNYRPQGMEGFLKSDER--QRLAKERREEREKCLAAREQQILEKQKRARLQYEKQM 91
R Q R + E + +ER Q+L +E+ E RE+ L REQ+ ++++ R + E++
Sbjct: 314 RREQQEERREQQERREQQEERREQQLRREQEERREQQL-RREQEEERREQQLRREQEEER 372
Query: 92 EERWRKLEEQRQREDQKRAAVEEKRKQKLREEEE-RLEAMMRR--SLERTQQLELKKK 146
E+ + E+Q +RE Q R + +R+Q+LR E++ R E +RR L R QQL +++
Sbjct: 373 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQE 430
Score = 53.9 bits (128), Expect = 5e-07
Identities = 37/105 (35%), Positives = 63/105 (60%), Gaps = 8/105 (7%)
Query: 50 KSDERQRLAKERREE--REKCLAAREQQILEK--QKRARLQYEKQMEERWRKLEEQRQRE 105
+ +E Q+ + RRE+ R K R +Q E+ Q+ R Q E++ E++ R+ +E+R+ +
Sbjct: 290 RQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQ 349
Query: 106 DQKRAAVEEKRKQKLR--EEEERLEAMMRR--SLERTQQLELKKK 146
+R EE+R+Q+LR +EEER E +RR L R QQL +++
Sbjct: 350 QLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQ 394
Score = 52.8 bits (125), Expect = 1e-06
Identities = 36/112 (32%), Positives = 65/112 (58%), Gaps = 8/112 (7%)
Query: 43 QGMEGFLKSDERQRLAKERR----EEREKCLAAREQQILEKQKRARLQYEKQMEERWRKL 98
Q + + + +R +E R EER + REQQ ++++ R + E++ E++ R+
Sbjct: 295 QQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRRE 354
Query: 99 EEQRQREDQ-KRAAVEEKRKQKLREEEE-RLEAMMRR--SLERTQQLELKKK 146
+E+ +RE Q +R EE+R+Q+LR E++ R E +RR L R QQL +++
Sbjct: 355 QEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 406
Score = 51.6 bits (122), Expect = 3e-06
Identities = 39/117 (33%), Positives = 65/117 (55%), Gaps = 16/117 (13%)
Query: 43 QGMEGFLKSDERQRLAKER----REEREKCLAAREQQILEKQKRARLQYEKQMEERWRKL 98
Q E L+ + +R +ER REE E L E+Q+L +++ R + E +E ++RK
Sbjct: 1028 QEEEQLLREEREKRRLQERERQYREEEE--LQQEEEQLLGEERETRRRQE--LERQYRKE 1083
Query: 99 EEQRQREDQKRAAVEEKRKQKLRE----EEERL----EAMMRRSLERTQQLELKKKY 147
EE +Q E+Q EKR+++ RE EEE L E ++R E+ ++ EL+++Y
Sbjct: 1084 EELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQY 1140
Score = 51.2 bits (121), Expect = 3e-06
Identities = 34/109 (31%), Positives = 61/109 (55%), Gaps = 3/109 (2%)
Query: 33 VRTSQPNYRPQGMEGFLKSDER-QRLAKERREEREKCLAAREQQILEKQKRARLQYEKQM 91
+R Q R Q + + + R Q+L +E+ EER + REQQ L ++++ R + + +
Sbjct: 339 LRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQ-LRREQQLRREQQLRR 397
Query: 92 EERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQ 140
E++ R+ E+Q +RE Q R + +R+Q+LR E+E + ER +Q
Sbjct: 398 EQQLRR-EQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQ 445
Score = 51.2 bits (121), Expect = 3e-06
Identities = 34/128 (26%), Positives = 63/128 (49%), Gaps = 14/128 (10%)
Query: 33 VRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQME 92
+R Q R Q + + Q+L +E++ RE+ EQ+ ++++ RL+ E++
Sbjct: 395 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEER 454
Query: 93 ERWRKLEEQRQREDQKRAAVEEKRKQ--------------KLREEEERLEAMMRRSLERT 138
W K EE+ +R +Q+R + KR Q + RE++ER E +RR E
Sbjct: 455 RDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEER 514
Query: 139 QQLELKKK 146
++ LK++
Sbjct: 515 REQRLKRQ 522
Score = 50.4 bits (119), Expect = 6e-06
Identities = 29/84 (34%), Positives = 48/84 (57%), Gaps = 5/84 (5%)
Query: 402 KILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQ 461
++ E+ RQ R +++ QE+ +EEQ+ + EE KR+ E ER EE R+Q++E
Sbjct: 1836 RLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKE---- 1891
Query: 462 EEEKKKQEGEEKRKAGEEAKRKAE 485
E++ +Q GE K + G+ R E
Sbjct: 1892 -EQRHRQVGEIKSQEGKGHGRLLE 1914
Score = 50.1 bits (118), Expect = 7e-06
Identities = 33/107 (30%), Positives = 65/107 (60%), Gaps = 8/107 (7%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQI--LEKQKRARLQYEKQMEERWRKLEEQRQ 103
E L+ +E + +E + +RE L E+Q+ LE+Q+ R + E++ +++ + E+Q +
Sbjct: 250 ETVLRKEEEKLQEEEPQRQRE--LQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLR 307
Query: 104 R--EDQKRAAVEEKRKQKLREE--EERLEAMMRRSLERTQQLELKKK 146
R E+++R EE+R+Q+ R E EER E +RR E ++ +L+++
Sbjct: 308 RKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRRE 354
Score = 49.7 bits (117), Expect = 1e-05
Identities = 31/104 (29%), Positives = 62/104 (59%), Gaps = 10/104 (9%)
Query: 52 DERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAA 111
++R+R +ER+ E+ L E+Q+L +++ R + E+ E ++RK ++ +Q+E+Q
Sbjct: 919 EKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQER--ERQYRKDKKLQQKEEQLLGE 976
Query: 112 VEEKRKQKLRE----EEERL----EAMMRRSLERTQQLELKKKY 147
EKR+++ RE EEE L E ++R E+ ++ E +++Y
Sbjct: 977 EPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQY 1020
Score = 49.7 bits (117), Expect = 1e-05
Identities = 39/130 (30%), Positives = 70/130 (53%), Gaps = 16/130 (12%)
Query: 34 RTSQPNYRPQGMEGFLKSDERQRLAKE----RREEREKC------LAAREQQIL--EKQK 81
R Q R + L+ E Q L +E RR+EREK L E+Q+L E++K
Sbjct: 951 RRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREK 1010
Query: 82 RARLQYEKQ--MEERWRKLEEQRQREDQKRAAVEEKRKQKLREEE--ERLEAMMRRSLER 137
R R ++E+Q ++ ++ EEQ RE++++ ++E+ +Q EEE + E ++ E
Sbjct: 1011 RRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERET 1070
Query: 138 TQQLELKKKY 147
++ EL+++Y
Sbjct: 1071 RRRQELERQY 1080
Score = 49.3 bits (116), Expect = 1e-05
Identities = 35/98 (35%), Positives = 55/98 (56%), Gaps = 11/98 (11%)
Query: 55 QRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQK-RAAVE 113
Q+L +E+ E RE+ L E++ LE+++R + +Q E R + L+ + +R Q+ + E
Sbjct: 536 QQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQE 595
Query: 114 EKRKQKL-REEEERLEAMMRRSL---------ERTQQL 141
E+ +Q+L REE ERLE RR ER QQL
Sbjct: 596 ERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQL 633
Score = 48.9 bits (115), Expect = 2e-05
Identities = 31/81 (38%), Positives = 50/81 (61%), Gaps = 4/81 (4%)
Query: 49 LKSDER--QRLAKERREE--REKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQR 104
L+ +ER QRL +E EE R++ L + EQ+ +Q+ R Q E++ + R+ EE+R
Sbjct: 610 LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLE 669
Query: 105 EDQKRAAVEEKRKQKLREEEE 125
+ KR EE+R+Q+L EEE+
Sbjct: 670 QRLKREHEEERREQELAEEEQ 690
Score = 48.9 bits (115), Expect = 2e-05
Identities = 40/130 (30%), Positives = 66/130 (50%), Gaps = 16/130 (12%)
Query: 34 RTSQPNYRPQGMEGFLKSDERQRLAKERREER----------EKCLAAREQQIL--EKQK 81
R Q R E L+ +E Q L +ER R E+ L E+Q+L E +K
Sbjct: 1041 RRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEK 1100
Query: 82 RARLQYEKQM--EERWRKLEEQRQREDQKRAAVEEKRKQKLREEE--ERLEAMMRRSLER 137
R R + E+Q EE ++ EEQ RE++++ +E +Q EEE + E ++R E+
Sbjct: 1101 RRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEK 1160
Query: 138 TQQLELKKKY 147
++ EL+++Y
Sbjct: 1161 RRRQELERQY 1170
Score = 48.5 bits (114), Expect = 2e-05
Identities = 45/129 (34%), Positives = 69/129 (53%), Gaps = 22/129 (17%)
Query: 34 RTSQPNYRPQGMEGFLKSDERQRLAKE----RREERE------KCLAAREQQIL--EKQK 81
R Q R E L+ +E Q L +E RR+ERE K L +E+Q+L E +K
Sbjct: 921 RRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEK 980
Query: 82 RARLQYEKQM--EERWRKLEEQRQREDQKRAAVEE-----KRKQKLREEEERL---EAMM 131
R R + EK+ EE ++ EEQ RE++++ +E ++K +L++EEE+L E
Sbjct: 981 RRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREK 1040
Query: 132 RRSLERTQQ 140
RR ER +Q
Sbjct: 1041 RRLQERERQ 1049
Score = 47.8 bits (112), Expect = 4e-05
Identities = 36/118 (30%), Positives = 57/118 (48%), Gaps = 3/118 (2%)
Query: 34 RTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQY--EKQM 91
R Q R Q + + Q+L +E++ RE+ L REQQ+ +Q+ R Q +Q
Sbjct: 372 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR-REQQLRREQQLRREQQLRREQE 430
Query: 92 EERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
EER + EQ +RE + + EE+R REEE RR + + E +++ W
Sbjct: 431 EERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERW 488
Score = 47.8 bits (112), Expect = 4e-05
Identities = 37/118 (31%), Positives = 61/118 (51%), Gaps = 13/118 (11%)
Query: 34 RTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEE 93
R Q R E L+ +E Q L REEREK R +Q LE+Q R + +++ E+
Sbjct: 1101 RRRQERERQCREEEELQQEEEQLL----REEREK----RRRQELERQYREEEEVQQEEEQ 1152
Query: 94 RWRKLEEQRQREDQKRAAVEE-----KRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
R+ E+R+R++ +R EE + +Q LREE+E+ R ++L+ +K+
Sbjct: 1153 LLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKR 1210
Score = 47.8 bits (112), Expect = 4e-05
Identities = 30/109 (27%), Positives = 61/109 (55%), Gaps = 7/109 (6%)
Query: 37 QPNYRPQGMEGFLKSDE---RQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEE 93
Q +R Q FL+ ++ RQ ++RR++R++ EQ +Q+R Q +Q +
Sbjct: 1522 QQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQL---RQEREEQQLSRQERD 1578
Query: 94 RWRKLEEQR-QREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQL 141
R +LEEQ+ +R++Q+R +E++++ + +E +++L R +QL
Sbjct: 1579 RKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQL 1627
Score = 47.4 bits (111), Expect = 5e-05
Identities = 43/139 (30%), Positives = 75/139 (53%), Gaps = 21/139 (15%)
Query: 27 IAEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKE----RREEREKCLAAREQQILEKQKR 82
+ E R Q R E L+ +E Q L +E RR+ERE+ RE++ L++++
Sbjct: 1064 LGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERER--QCREEEELQQEEE 1121
Query: 83 ARLQYEK------QMEERWRKLEEQRQREDQ-KRAAVEEKRKQKL----REEEE---RLE 128
L+ E+ ++E ++R+ EE +Q E+Q R E++R+Q+L REEEE E
Sbjct: 1122 QLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEE 1181
Query: 129 AMMRRSLERTQQLELKKKY 147
++R E+ +Q E +++Y
Sbjct: 1182 QLLREEQEKRRQ-ERERQY 1199
Score = 47.4 bits (111), Expect = 5e-05
Identities = 36/129 (27%), Positives = 67/129 (51%), Gaps = 11/129 (8%)
Query: 29 EPGAVRTSQPNYRPQGMEGFLKSDERQRLAKER--REEREKCLAAREQQILEKQKRARLQ 86
E +R + R Q +E + +E + +E+ REE EK R +Q LE+Q R +
Sbjct: 1120 EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEK----RRRQELERQYREEEE 1175
Query: 87 YEKQMEERWRKLEEQRQREDQKRAAVEE-----KRKQKLREEEERLEAMMRRSLERTQQL 141
+++ E+ R+ +E+R++E +++ EE KRKQ+ R+E++R + + E+ +
Sbjct: 1176 LQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAV 1235
Query: 142 ELKKKYSWG 150
K Y G
Sbjct: 1236 RDNKVYCKG 1244
Score = 46.6 bits (109), Expect = 8e-05
Identities = 40/140 (28%), Positives = 73/140 (52%), Gaps = 8/140 (5%)
Query: 7 GSGTGSRPEGTARGTSLPGKIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERREERE 66
G TG E AR GK + R + R + + L+ + QR +++R+E+E
Sbjct: 90 GQATGLDEEKRAR---CDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQR-RRQKRQEQE 145
Query: 67 KCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEER 126
+ LA E+Q ++++ + +++ EE WR+ +E ++RE ++RA E+ + K E EE
Sbjct: 146 RELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQERE-ERRAEEEQLQSCKGHETEEF 204
Query: 127 LEAMMRRSLERTQQLELKKK 146
+ L R + LEL++K
Sbjct: 205 PD---EEQLRRRELLELRRK 221
Score = 46.6 bits (109), Expect = 8e-05
Identities = 35/120 (29%), Positives = 63/120 (52%), Gaps = 19/120 (15%)
Query: 43 QGMEGFLKSDERQRLAKE-----RREEREKCLAAREQQILEKQKRARLQYEKQM------ 91
+G E L+ ER R +E RR+ERE+ EQQ+ ++ + + E+Q+
Sbjct: 1678 EGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQ 1737
Query: 92 -----EERWRKL--EEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELK 144
+ER+RK+ EEQ + E +++ ++R +K REEE+ + + L R+Q+ + K
Sbjct: 1738 EQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQL-RSQESDRK 1796
Score = 46.2 bits (108), Expect = 1e-04
Identities = 32/112 (28%), Positives = 57/112 (50%), Gaps = 18/112 (16%)
Query: 53 ERQRLAKERREER-----------EKCLAAREQQIL----EKQKRARLQYEKQMEERWRK 97
E ++L +E RE+R E+ + E+Q+L EK++R L+ + + EE ++
Sbjct: 1119 EEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQ 1178
Query: 98 LEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
EEQ RE+Q++ E +R+ + EEE L+ R+ R + K+ W
Sbjct: 1179 EEEQLLREEQEKRRQERERQYR---EEEELQRQKRKQRYRDEDQRSDLKWQW 1227
Score = 45.4 bits (106), Expect = 2e-04
Identities = 30/98 (30%), Positives = 54/98 (55%), Gaps = 5/98 (5%)
Query: 52 DERQRLAKERRE---EREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQK 108
+E Q+L +ER E E+ L RE+Q L +Q+R R E+ E++ R+ E R+ +Q+
Sbjct: 1450 EEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEE--EQQLRRQERDRKFREQE 1507
Query: 109 RAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
+ E +RK E++ + R+ L+ QQL +++
Sbjct: 1508 LRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQER 1545
Score = 45.1 bits (105), Expect = 2e-04
Identities = 37/124 (29%), Positives = 68/124 (54%), Gaps = 11/124 (8%)
Query: 33 VRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQME 92
+R Q R Q + + Q+L +E++ RE+ L REQQ+ +Q+ R + + + E
Sbjct: 383 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR-REQQLRREQEEERHEQKHEQE 441
Query: 93 ERWRKLE-EQRQ------REDQKRAAVEEKRKQKLR--EEEERLEAMMR-RSLERTQQLE 142
R ++L+ EQ + RE++ +E+RKQ+L+ +EEER E ++ ER +Q E
Sbjct: 442 RREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQE 501
Query: 143 LKKK 146
+++
Sbjct: 502 RREQ 505
Score = 45.1 bits (105), Expect = 2e-04
Identities = 31/97 (31%), Positives = 53/97 (54%), Gaps = 15/97 (15%)
Query: 53 ERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAV 112
ERQ A+ER++ ++ L E EK++R R + E++ E ++ + EEQ QR +
Sbjct: 795 ERQLRAEERQQREQRFLPEEE----EKEQRRRQRREREKELQFLEEEEQLQRRE------ 844
Query: 113 EEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
R Q+L+EEE+ L+ R R+Q+ +K+ W
Sbjct: 845 ---RAQQLQEEEDGLQEDQER--RRSQEQRRDQKWRW 876
Score = 45.1 bits (105), Expect = 2e-04
Identities = 32/99 (32%), Positives = 61/99 (61%), Gaps = 14/99 (14%)
Query: 53 ERQRLAKE----RREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQK 108
E+Q L +E +REEREK R +Q E+Q R Q +++ E+ R+ E+R+R++++
Sbjct: 902 EQQLLQEEEEELQREEREK----RRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERE 957
Query: 109 RAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKY 147
R + ++ +KL+++EE+L + E+ ++ E +KKY
Sbjct: 958 R---QYRKDKKLQQKEEQL---LGEEPEKRRRQEREKKY 990
Score = 45.1 bits (105), Expect = 2e-04
Identities = 34/115 (29%), Positives = 63/115 (54%), Gaps = 15/115 (13%)
Query: 34 RTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEE 93
R + ++ QG + FL +E QRL RR+ERE+ EQQ+ +++ +L+ ++ +
Sbjct: 1363 REEELRHQEQGRK-FL--EEEQRL---RRQERERKFLKEEQQLRCQEREQQLRQDR--DR 1414
Query: 94 RWRKLEEQRQREDQKRAAVEEK-------RKQKLREEEERLEAMMRRSLERTQQL 141
++R+ E+Q R+++ R EE+ R++K EEE++L R +QL
Sbjct: 1415 KFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQL 1469
Score = 45.1 bits (105), Expect = 2e-04
Identities = 33/109 (30%), Positives = 58/109 (53%), Gaps = 13/109 (11%)
Query: 49 LKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKL----EEQRQR 104
L ER R K R EE++ RE++ LE++++ R + ++ E + L E+Q R
Sbjct: 1423 LSRQERDR--KFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHR 1480
Query: 105 EDQKRAAVEE-------KRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
+++ R +EE +R +K RE+E R + R+ LE QQL +++
Sbjct: 1481 QERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQR 1529
Score = 45.1 bits (105), Expect = 2e-04
Identities = 35/111 (31%), Positives = 58/111 (52%), Gaps = 18/111 (16%)
Query: 49 LKSDERQRLAKE---RREEREKCLAAREQQILEKQKRAR-LQYEKQM----------EER 94
L+ ER R +E R +E E+ EQQ+ +Q++ + LQ E+Q+ ++R
Sbjct: 1494 LRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDR 1553
Query: 95 WRKLEEQRQ----REDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQL 141
RK E+ Q RE+Q+ + E RK +L E++ R + R+ +E QQL
Sbjct: 1554 DRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQL 1604
Score = 45.1 bits (105), Expect = 2e-04
Identities = 43/142 (30%), Positives = 74/142 (52%), Gaps = 23/142 (16%)
Query: 29 EPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERRE----EREKCLAAREQQILEKQKRAR 84
E VR + + E L+ E Q+ ++ R+ E E+ L RE+Q L +Q+R R
Sbjct: 1584 EEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDR 1643
Query: 85 --LQYEKQM--EERWRKL----------EEQRQREDQKRAAVEEKRKQKLREEEERL--E 128
L+ E Q+ +ER ++L EEQ +E +++ ++R +K REEE++L +
Sbjct: 1644 KFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQ 1703
Query: 129 AMMRRSLERTQQL---ELKKKY 147
R+ L+ QQL EL++K+
Sbjct: 1704 ERERKFLQEEQQLRRQELERKF 1725
Score = 45.1 bits (105), Expect = 2e-04
Identities = 35/98 (35%), Positives = 57/98 (58%), Gaps = 14/98 (14%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRAR--LQYEKQ-----MEERWRKL 98
E L+ E Q+L RR+ER++ EQQ L +Q+R R LQ E+Q +E ++R+
Sbjct: 1673 EQLLQEGEEQQL---RRQERDRKFREEEQQ-LRRQERERKFLQEEQQLRRQELERKFREE 1728
Query: 99 EEQRQREDQKRAAVEEKRKQKLREEE---ERLEAMMRR 133
E+ RQ +Q++ +E+ ++ L EE+ ER E +RR
Sbjct: 1729 EQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRR 1766
Score = 44.7 bits (104), Expect = 3e-04
Identities = 42/125 (33%), Positives = 61/125 (48%), Gaps = 26/125 (20%)
Query: 41 RPQGMEGFLKSDE----RQRLAKER--------------REEREKCLAAREQQILEKQKR 82
R Q + FL +E R+R +ER R ER + L E + E Q+R
Sbjct: 803 RQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQER 862
Query: 83 ARLQYEKQMEERWR-KLEEQRQREDQ----KRAAVEEKRK--QKLREEEERLEAMMRRSL 135
R Q E++ +++WR +LEE+R+R K A E+ RK Q L+EEEE L+ R
Sbjct: 863 RRSQ-EQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKR 921
Query: 136 ERTQQ 140
R +Q
Sbjct: 922 RRQEQ 926
Score = 44.7 bits (104), Expect = 3e-04
Identities = 32/112 (28%), Positives = 59/112 (52%), Gaps = 11/112 (9%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQ----------ILEKQKRARLQY-EKQMEER 94
+G + ER+R ++RR+++ + E++ L++Q R Q +++ EE
Sbjct: 854 DGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEEL 913
Query: 95 WRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
R+ E+R+R++Q+R EE++ Q+ E+ R E RR ER +Q KK
Sbjct: 914 QREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKK 965
Score = 44.7 bits (104), Expect = 3e-04
Identities = 35/130 (26%), Positives = 62/130 (47%), Gaps = 33/130 (25%)
Query: 50 KSDERQRLAKERREER-------------EKCLAAREQQILEKQKRARLQYEKQM----- 91
KS E ++L +E REE+ E+ L RE+Q L +Q+R R E+++
Sbjct: 1313 KSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQ 1372
Query: 92 -------------EERWRKL--EEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLE 136
+ER RK EEQ+ R ++ + + R +K REEE++L R
Sbjct: 1373 GRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKF 1432
Query: 137 RTQQLELKKK 146
R ++ +++++
Sbjct: 1433 REEEQQVRRQ 1442
Score = 44.3 bits (103), Expect = 4e-04
Identities = 31/109 (28%), Positives = 56/109 (51%), Gaps = 8/109 (7%)
Query: 41 RPQGMEGFLKSDERQRLAKER----REEREKCLAAREQQILEKQKRARLQYEKQM--EER 94
R Q E L+ D ++ +E R+ER++ EQQ+ +++ + E+Q +ER
Sbjct: 1400 RCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQER 1459
Query: 95 WRKLEEQRQ--REDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQL 141
RK E+ Q +E +++ ++R +K EEE++L R R Q+L
Sbjct: 1460 HRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQEL 1508
Score = 43.9 bits (102), Expect = 5e-04
Identities = 31/122 (25%), Positives = 66/122 (54%), Gaps = 6/122 (4%)
Query: 29 EPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYE 88
+ G R + + + E L+ E +R ++++EE ++ + Q EK +R R +
Sbjct: 726 QEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLS 785
Query: 89 KQ---MEERWRKLE-EQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELK 144
+ E+R R+L E+RQ+ +Q+ EE+++Q+ R+ ER + + + LE +QL+ +
Sbjct: 786 ARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKEL--QFLEEEEQLQRR 843
Query: 145 KK 146
++
Sbjct: 844 ER 845
Score = 43.1 bits (100), Expect = 0.001
Identities = 28/106 (26%), Positives = 60/106 (56%), Gaps = 14/106 (13%)
Query: 52 DERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAA 111
++R+R +ER+ ++K L +E+Q+L ++ R + E+ E+++R+ EE +Q E+Q
Sbjct: 949 EKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQER--EKKYREEEELQQEEEQLLR- 1005
Query: 112 VEEKRKQKLREEEERL----------EAMMRRSLERTQQLELKKKY 147
EE+ K++ +E E + E ++R E+ + E +++Y
Sbjct: 1006 -EEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQY 1050
Score = 43.1 bits (100), Expect = 0.001
Identities = 32/125 (25%), Positives = 62/125 (49%), Gaps = 4/125 (3%)
Query: 26 KIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERREER----EKCLAAREQQILEKQK 81
KI E +R + + + E K E ++L +ER E++ E RE++ L +++
Sbjct: 1748 KILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQER 1807
Query: 82 RARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQL 141
+ +Q + ++R EEQ Q E+Q++ +E+ +Q EE+ + RR + Q
Sbjct: 1808 EEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQE 1867
Query: 142 ELKKK 146
E +K+
Sbjct: 1868 EEQKR 1872
Score = 42.7 bits (99), Expect = 0.001
Identities = 25/90 (27%), Positives = 49/90 (54%), Gaps = 2/90 (2%)
Query: 34 RTSQPNYRPQGMEGFLKSDER--QRLAKERREEREKCLAAREQQILEKQKRARLQYEKQM 91
R Q R Q ++ +ER Q L E +EER + REQQ +Q+ R + E+++
Sbjct: 609 RLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERL 668
Query: 92 EERWRKLEEQRQREDQKRAAVEEKRKQKLR 121
E+R ++ E+ +RE + +E+ +++++
Sbjct: 669 EQRLKREHEEERREQELAEEEQEQARERIK 698
Score = 41.6 bits (96), Expect = 0.003
Identities = 31/110 (28%), Positives = 53/110 (48%), Gaps = 13/110 (11%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKR 109
+ ER+R + R E+ RE+Q K++ + Q EKQ+ R+ + +RQ D+K
Sbjct: 1279 REQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKF 1338
Query: 110 AAVE-------------EKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
E ++R +K REEE R + R+ LE Q+L +++
Sbjct: 1339 REEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQER 1388
Score = 41.6 bits (96), Expect = 0.003
Identities = 35/111 (31%), Positives = 66/111 (59%), Gaps = 15/111 (13%)
Query: 49 LKSDERQRLAKERRE-------EREKCLAAREQQILEKQKRARLQYEKQM--EERWRKL- 98
L +ER+ K RR+ E E+ L RE+Q L +Q+R R E+++ +E+ RK
Sbjct: 1320 LLREEREE--KRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFL 1377
Query: 99 -EEQR-QREDQKRAAVEEKRKQKLREEEERL-EAMMRRSLERTQQLELKKK 146
EEQR +R++++R ++E+++ + +E E++L + R+ E QQL +++
Sbjct: 1378 EEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQER 1428
Score = 41.2 bits (95), Expect = 0.003
Identities = 32/110 (29%), Positives = 57/110 (51%), Gaps = 11/110 (10%)
Query: 37 QPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQM---EE 93
+P R Q E L+ D ++ REE + EQQ+ +++ + + E+Q +E
Sbjct: 1649 EPQLRRQEREQQLRHDRDRKF----REEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQE 1704
Query: 94 RWRKL--EEQ--RQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQ 139
R RK EEQ R++E +++ EE+ +Q+ +E+ R + R+ LE Q
Sbjct: 1705 RERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQ 1754
Score = 40.8 bits (94), Expect = 0.005
Identities = 42/155 (27%), Positives = 73/155 (47%), Gaps = 36/155 (23%)
Query: 28 AEPGAVRTS-QPNYRPQGMEGFLKSDER---------------QRLAKERREEREKCLAA 71
+E G R S +P R Q E L+++ER QR + R E+E
Sbjct: 777 SERGRQRLSARPPLREQ-RERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLE 835
Query: 72 REQQILEKQKRARLQYEKQ-MEERWRKLEEQRQREDQK-RAAVEEKRK------------ 117
E+Q+ +++ +LQ E+ ++E + Q QR DQK R +EE+RK
Sbjct: 836 EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPAL 895
Query: 118 -QKLREEEERL----EAMMRRSLERTQQLELKKKY 147
++LR+E++ L E + R E+ ++ E +++Y
Sbjct: 896 QEQLRKEQQLLQEEEEELQREEREKRRRQEQERQY 930
Score = 40.8 bits (94), Expect = 0.005
Identities = 28/118 (23%), Positives = 63/118 (53%), Gaps = 4/118 (3%)
Query: 32 AVRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQM 91
AVR ++ + + E F + ++ Q ++ +++ + L ++++ E+++R Q ++
Sbjct: 1234 AVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHF 1293
Query: 92 EERWRKLEEQRQREDQKRAAVEEKRKQKLREEEE---RLEAMMRRSLERTQQLELKKK 146
E +LE + Q+E ++R ++ KQ LREE E R + R+ E Q L+ +++
Sbjct: 1294 PEE-EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREE 1350
Score = 40.4 bits (93), Expect = 0.006
Identities = 35/108 (32%), Positives = 61/108 (56%), Gaps = 12/108 (11%)
Query: 49 LKSDERQRLAKER--REEREKCLAAREQQILEKQKRAR--LQYEKQM--EERWRKLEEQR 102
L+ ER R +E R + + E+Q L +Q+R R L+ E+Q+ +ER ++L + R
Sbjct: 1353 LRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDR 1412
Query: 103 QR---EDQKRAAVEEKRKQKLREEEE--RLEAMMRRSLERTQQLELKK 145
R E++++ + +E R +K REEE+ R + R+ LE QQL ++
Sbjct: 1413 DRKFREEEQQLSRQE-RDRKFREEEQQVRRQERERKFLEEEQQLRQER 1459
Score = 40.0 bits (92), Expect = 0.008
Identities = 37/137 (27%), Positives = 64/137 (46%), Gaps = 10/137 (7%)
Query: 15 EGTARGTSLPGKIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERREER----EKCLA 70
E R L K E +R + + E + K E ++L ER E++ E+
Sbjct: 1713 EQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRK 1772
Query: 71 AREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERL--- 127
RE++ L +Q+R Q Q +R + EEQ ++E +++ ++R K R EEE+L
Sbjct: 1773 FREEEQL-RQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLE 1831
Query: 128 --EAMMRRSLERTQQLE 142
E +R+ +R + E
Sbjct: 1832 EQEQRLRQERDRQYRAE 1848
Score = 39.7 bits (91), Expect = 0.010
Identities = 30/113 (26%), Positives = 61/113 (53%), Gaps = 19/113 (16%)
Query: 48 FLKSDER---QRLAKERREEREKCLAAREQQILEKQKRARLQYEKQM---EERWRKL--E 99
FLK +++ Q ++ R++R++ EQQ+ +++ + + E+Q +ER RK E
Sbjct: 1392 FLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEE 1451
Query: 100 EQRQREDQKRA------AVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
EQ+ R+++ R ++E+ +Q+L +E R+ LE QQL +++
Sbjct: 1452 EQQLRQERHRKFREEEQLLQEREEQQLHRQERD-----RKFLEEEQQLRRQER 1499
Score = 39.7 bits (91), Expect = 0.010
Identities = 28/119 (23%), Positives = 67/119 (56%), Gaps = 8/119 (6%)
Query: 34 RTSQPNYRPQGMEGFLKSD---ERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQ 90
R Q +R + FL+ + RQ ++ R +R++ EQ + E +++ + E+
Sbjct: 1631 REEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQER- 1689
Query: 91 MEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEE--RLEAMMRRSLERTQQLELKKKY 147
+ ++R+ E+Q +R++++R ++E+++ + +E E R E +R+ E+ +QL +++Y
Sbjct: 1690 -DRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQ-EQLRRQERY 1746
Score = 39.7 bits (91), Expect = 0.010
Identities = 36/160 (22%), Positives = 70/160 (43%), Gaps = 12/160 (7%)
Query: 13 RPEGTARGTSLPGKIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERREER------- 65
R E R K E +R + + + E K E ++L +ER E++
Sbjct: 1759 REEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRD 1818
Query: 66 EKCLAAREQ-QILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKLREEE 124
K EQ Q+ E+++R R + ++Q + +++ R +++ EE++K++ E
Sbjct: 1819 GKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERER 1878
Query: 125 ERLEAMMRRSLERTQQL----ELKKKYSWGAPLAIGPGGH 160
+ E +RR + Q+ E+K + G + PG H
Sbjct: 1879 KLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTH 1918
Score = 38.9 bits (89), Expect = 0.017
Identities = 29/102 (28%), Positives = 57/102 (55%), Gaps = 5/102 (4%)
Query: 48 FLKSDE---RQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQR 104
FL+ ++ RQ L ++ REE E+ EQ+ L +Q+R R E++ + R + E+Q +R
Sbjct: 1709 FLQEEQQLRRQELERKFREE-EQLRQETEQEQLRRQERYRKILEEE-QLRPEREEQQLRR 1766
Query: 105 EDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
+++ R EE++ ++ REE++ R +QL +++
Sbjct: 1767 QERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQERE 1808
Score = 38.1 bits (87), Expect = 0.029
Identities = 30/129 (23%), Positives = 65/129 (50%), Gaps = 18/129 (13%)
Query: 33 VRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILE---KQKRARL---- 85
+R Q R Q ++ + +E +RL + + E E+ REQ++ E +Q R R+
Sbjct: 647 LRREQQERREQRLK---REEEEERLEQRLKREHEE--ERREQELAEEEQEQARERIKSRI 701
Query: 86 -----QYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQ 140
Q E + + R K+ + ++++ +R E++ K++ RE E + + R+ + Q+
Sbjct: 702 PKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQE-EERAHRQQQE 760
Query: 141 LELKKKYSW 149
E ++ ++W
Sbjct: 761 EEQRRDFTW 769
Score = 38.1 bits (87), Expect = 0.029
Identities = 31/121 (25%), Positives = 59/121 (48%), Gaps = 14/121 (11%)
Query: 34 RTSQPNYRPQGMEGFLKSDERQRLAKER----REEREKCLAAREQQILEKQKRARLQYEK 89
R + R Q + + +E+ R +E R+ER++ EQ++ +++ + ++
Sbjct: 1542 RQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDE 1601
Query: 90 QMEERWRKLEEQRQREDQK----RAAVEEKRKQKL-REEEERL----EAMMRRSLERTQQ 140
Q R ++ RQ D+K ++E+ +Q+L R+E +R E +RR ER QQ
Sbjct: 1602 QQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQ-EREQQ 1660
Query: 141 L 141
L
Sbjct: 1661 L 1661
Score = 38.1 bits (87), Expect = 0.029
Identities = 29/112 (25%), Positives = 54/112 (48%), Gaps = 11/112 (9%)
Query: 41 RPQGMEGFLKSDERQRL-----AKERREEREKCLAAREQQILEKQKRARLQYEKQMEER- 94
R + E L ER R K RR+E+E+ EQQ+ ++ + +L+ E+ + R
Sbjct: 1564 RQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRE 1623
Query: 95 -----WRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQL 141
+ E+Q R+++ R +EE+ + + +E E++L R +QL
Sbjct: 1624 DEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQL 1675
Score = 37.7 bits (86), Expect = 0.038
Identities = 31/122 (25%), Positives = 54/122 (44%), Gaps = 29/122 (23%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQY-EKQMEERWRKLEEQR------ 102
++D RQ R ++E +EQ+ +++ + LQ+ E++ R ++ EEQR
Sbjct: 711 EADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQ 770
Query: 103 ----------------------QREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQ 140
QRE Q RA ++R+Q+ EEE E R+ ER ++
Sbjct: 771 WQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKE 830
Query: 141 LE 142
L+
Sbjct: 831 LQ 832
Score = 36.2 bits (82), Expect = 0.11
Identities = 26/116 (22%), Positives = 57/116 (49%), Gaps = 16/116 (13%)
Query: 49 LKSDER-----QRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQ 103
LKS+E+ Q+L +E++E RE+ L RE++ ++R + ++E++ E+ EEQ Q
Sbjct: 634 LKSEEQEERRQQQLRREQQERREQRLK-REEEEERLEQRLKREHEEERREQELAEEEQEQ 692
Query: 104 REDQKRAAV----------EEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
++ ++ + + R+ K+ + E RR + ++ + + W
Sbjct: 693 ARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQW 748
Score = 35.4 bits (80), Expect = 0.19
Identities = 29/119 (24%), Positives = 58/119 (48%), Gaps = 5/119 (4%)
Query: 29 EPGAVRTSQPNYRPQGMEGFLKSDERQRLAKER--REEREKCLAAREQQILEKQKRARLQ 86
E +R R Q +E + +E + +E+ REE+EK RE+Q E+++ R +
Sbjct: 1150 EEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQK 1209
Query: 87 YEKQMEERWRKLEEQRQREDQKRAAVEEKR---KQKLREEEERLEAMMRRSLERTQQLE 142
+++ + ++ + + Q E +K AV + + K + E+ +LE R + Q L+
Sbjct: 1210 RKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQ 1268
Score = 35.4 bits (80), Expect = 0.19
Identities = 24/95 (25%), Positives = 51/95 (53%), Gaps = 4/95 (4%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQME--ERWRKLEEQRQ--RE 105
+ D + L +++ +RE+ +Q+ + +L+ E+Q E R RK +E++Q RE
Sbjct: 1264 QQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLRE 1323
Query: 106 DQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQ 140
+++ ++ +K REEE+ L+ + L R ++
Sbjct: 1324 EREEKRRRQETDRKFREEEQLLQEREEQPLRRQER 1358
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 87.4 bits (215), Expect = 4e-17
Identities = 124/533 (23%), Positives = 219/533 (41%), Gaps = 64/533 (12%)
Query: 49 LKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQK 108
+KS+E+ ++ + + E+E + + + + + + EK+ +E K EE + E+ +
Sbjct: 438 VKSEEKIKVVE--KSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAE 495
Query: 109 RAAVEEKRKQKLREE----EERLEAMMRRSLERTQQLELKKKYSWGAPLAIGPGGHDACD 164
EE+ K EE E+ ++ ++ + + + +K +P + A
Sbjct: 496 GG--EEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEV-KSPEKAKS 552
Query: 165 KLSTSTMSLPKPTEPPMNKRLSSSTVAISYSPDRVFHVCPRLA--PLGPLNPSYKSSPTR 222
S P+ P + S + V SP++ A P +P SP +
Sbjct: 553 PAKEEAKSPPEAKSPEKEEAKSPAEVK---SPEKAKSPAKEEAKSPAEAKSPEKAKSPVK 609
Query: 223 NIEKKKATSTSTSGAGDVGKEALSGGEASLVEKVKRGQRTATSLPVVNFGSPLRRCEFSG 282
K A + S V +EA S E EK K + P SP +
Sbjct: 610 EEAKSPAEAKS-----PVKEEAKSPAEVKSPEKAKSPTKEEAKSP-EKAKSPEK------ 657
Query: 283 GIPKRPSSPVISKTATKAYPQSPKTTKPPYPG---SPVKYRLPALSGQDMPKRKAEKEKS 339
+ SP +K+ KA +SP+ K P SP K + P P EK KS
Sbjct: 658 ---EEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSP----EKAKS 710
Query: 340 NKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTAGTTDAGE 399
+ E ++A P EEA EK + +A++ P E
Sbjct: 711 PVKEEAKSPEKAKSPVKEEA--------KTPEKAKSPVKEEAKSPEKAKSP--------E 754
Query: 400 AAKILAEKRRQARLQKEQEEQERVEK--EEQDRLEREELKRKAEEERLRLEEEARKQEEE 457
AK L K +A+ ++E + +K E+ +EE+K E+ + L+E+A+ E+E
Sbjct: 755 KAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVK-SPEKAKSPLKEDAKAPEKE 813
Query: 458 RKRQEEEK---KKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETK 514
++EE K K++E ++ K E K+ EE+ K E++K K +KEA + K
Sbjct: 814 IPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPK 873
Query: 515 AREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVK-KEDPK 566
E E + ++ ++ ++E E KK++ T + + P +V+ KED K
Sbjct: 874 VEEKKEPAVEKPKESKVEAKKEEAEDKKKVP-----TPEKEAPAKVEVKEDAK 921
Score = 86.3 bits (212), Expect = 9e-17
Identities = 124/519 (23%), Positives = 212/519 (40%), Gaps = 53/519 (10%)
Query: 104 REDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKK---KYSWGAPLAIGPGGH 160
+ ++K VE+ K+ + EE+ E + + ++ E K+ K G GG
Sbjct: 439 KSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGE 498
Query: 161 DACDKLSTSTMSLP-KPTEPPMNKRLSSSTVAISYSPDRVFHVCPRLAP---LGPLNPSY 216
+ + P K + P+ + S A S + +P P
Sbjct: 499 EETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEA 558
Query: 217 KSSP-TRNIEKKKATSTSTSGAGDVGK-----EALSGGEASLVEKVKRGQRTATSLPVVN 270
KS P ++ EK++A S + + + K EA S EA EK K + P
Sbjct: 559 KSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPA-E 617
Query: 271 FGSPLRRCEFSGGIPKRPSSPVISKTATKAYPQSPKTTKPPYPG---SPVKYRLPALSGQ 327
SP++ S P SP +K+ TK +SP+ K P SP K + P +
Sbjct: 618 AKSPVKEEAKS---PAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEA 674
Query: 328 DMPKR----------KAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAA 377
P++ EK KS + E ++A P EEA K + K A
Sbjct: 675 KSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEA--KSPEKAKSPVKEEAKT 732
Query: 378 GGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEK--EEQDRLEREE 435
KA++ + + E AK L K +A+ ++E + +K E+ +EE
Sbjct: 733 PEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEE 792
Query: 436 LKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGE--EAKRKAEEELL---- 489
+K E+ + L+E+A+ E+E ++EE K + EEK + + E +KAEEE
Sbjct: 793 VK-SPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATP 851
Query: 490 -LKEKQEQEKQE-------KAMIEKQKEAAETKAREVAEQMRLEREQIMLQI--EQERLE 539
+EK++ +K+E K +E++KE A K +E + + E + ++ ++
Sbjct: 852 KTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAP 911
Query: 540 RKKRIDEIMKRTRKSDVPPQVKKEDPKVGVQPAVCVEKK 578
K + E K K++V K+ D +P+ EKK
Sbjct: 912 AKVEVKEDAKPKEKTEVAK--KEPDDAKAKEPSKPAEKK 948
Score = 60.1 bits (144), Expect = 7e-09
Identities = 53/187 (28%), Positives = 88/187 (47%), Gaps = 6/187 (3%)
Query: 399 EAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEER 458
E K++ + ++ + +EQ E+ +V +E + E+E + + +EE EEEA EEE
Sbjct: 442 EKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEET 501
Query: 459 KR-QEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKARE 517
K EE E E K EEAK AE + KE+ + + K+ EK K A+ +A+
Sbjct: 502 KSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSP-EKAKSPAKEEAKS 560
Query: 518 VAEQMRLEREQIMLQIEQERLER-KKRIDEIMKRTRKSDVPPQVK---KEDPKVGVQPAV 573
E E+E+ E + E+ K E K ++ P + K KE+ K +
Sbjct: 561 PPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKS 620
Query: 574 CVEKKTK 580
V+++ K
Sbjct: 621 PVKEEAK 627
Score = 52.8 bits (125), Expect = 1e-06
Identities = 75/283 (26%), Positives = 117/283 (41%), Gaps = 24/283 (8%)
Query: 395 TDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQ 454
T+ + + + E+ + ++E +E+E E+EE + E EE K EE E+EA+
Sbjct: 461 TEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGE-EETKSPPAEEAASPEKEAKSP 519
Query: 455 EEERKRQEEEKKKQEGEEKR-----KAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKE 509
+E + E K E EE + K+ E+AK A+EE K E + EK E+ K
Sbjct: 520 VKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEE--AKSPPEAKSPEK---EEAKS 574
Query: 510 AAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKEDPKVGV 569
AE K+ E A+ +E+ E + E+ K +K KS P + K +
Sbjct: 575 PAEVKSPEKAKSP--AKEEAKSPAEAKSPEKAK---SPVKEEAKS--PAEAKSPVKEEAK 627
Query: 570 QPAVCVEKKTKLVVPNKMEINGLNTCQEVNGVDHAAPETYPQDIFSNGLKPAGGLIHLDA 629
PA V+ K P K E + + +PE + + P + A
Sbjct: 628 SPAE-VKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKA 686
Query: 630 LDGKSNSLDDS--TEEVQSMD--VSPVSKEELISIPEFSPVSE 668
+ KS S EE +S + SPV +E SPV E
Sbjct: 687 -EAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKE 728
Score = 50.4 bits (119), Expect = 6e-06
Identities = 90/448 (20%), Positives = 162/448 (36%), Gaps = 36/448 (8%)
Query: 49 LKSDERQR--LAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQRED 106
+KS E+ + +E + E + + ++++ ++ + + ++E + E + E
Sbjct: 578 VKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEK 637
Query: 107 QKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSWGAPLAIGPGGHDACDKL 166
K EE + + + E+ EA + + E K +P+ +
Sbjct: 638 AKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSP 697
Query: 167 STSTMSLPKPTEPPMNKRLSSSTVAISYSPDRVFHVCPRLAPLGPLNPSYKS-SPTRNIE 225
P+ + P+ + S A SP + P A P+ KS ++ E
Sbjct: 698 VKEEAKSPEKAKSPVKEEAKSPEKA--KSPVKEEAKTPEKAK-SPVKEEAKSPEKAKSPE 754
Query: 226 KKKATSTSTSGAGDVGKEALSGGEASLVEKVKRGQRTATSLPVVNFGSPLRRCEFSGG-- 283
K K + A KE EK K + P SPL+ +
Sbjct: 755 KAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPE-KAKSPLKEDAKAPEKE 813
Query: 284 IPKRPSSPVISKTATKAYPQSPKTTKPPY-------PGSPVKYRLPALSGQDMPKRKAEK 336
IPK+ V S + PQ K +PP P +P ++ PK++A K
Sbjct: 814 IPKKEE--VKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPK 871
Query: 337 EKSNKEREGTLA---QQAAGPQGEEALEKHVV---DKHASEKHAAAAGGKAENSAALGKP 390
K +++E + + + EEA +K V +K A K K + + K
Sbjct: 872 PKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKK 931
Query: 391 TAGTTDAGEAAKILAEKRRQARLQKEQEEQ-----------ERVEKEEQDRLEREELKRK 439
A E +K AEK+ A +K+ +E+ E KE+ L +E K K
Sbjct: 932 EPDDAKAKEPSKP-AEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPK 990
Query: 440 AEEERLRLEEEARKQEEERKRQEEEKKK 467
AE+ + + + K E++ K
Sbjct: 991 AEKAEKSSSTDQKDSKPPEKATEDKAAK 1018
Score = 39.7 bits (91), Expect = 0.010
Identities = 54/197 (27%), Positives = 86/197 (43%), Gaps = 28/197 (14%)
Query: 371 EKHAAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDR 430
E H + G+A AAL + AG + GE + + R A L+ Q R
Sbjct: 119 EAHNRSLEGEA---AALRQQQAGRSAMGELYEREVREMRGAVLRLGAARG-------QLR 168
Query: 431 LEREELKRKAEEERLRLEEEARKQEE--------ERKRQEEEKKKQEGEEKRKAGEE--- 479
LE+E L R RL++EAR++EE R QE E + + ++K +A +E
Sbjct: 169 LEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAARVDLQKKAQALQEECG 228
Query: 480 -AKRKAEEEL--LLKEKQEQEKQEKAMIEKQKEAAE----TKAREVAEQMRLEREQIMLQ 532
+R +EE+ LL + Q + M + ++A + + RE+ Q+ Q LQ
Sbjct: 229 YLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALREIRAQLEGHAVQSTLQ 288
Query: 533 IEQERLERKKRIDEIMK 549
E+ R R+ E K
Sbjct: 289 SEEWFRVRLDRLSEAAK 305
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 84.0 bits (206), Expect = 5e-16
Identities = 66/248 (26%), Positives = 130/248 (52%), Gaps = 21/248 (8%)
Query: 335 EKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTAGT 394
E+E +E+EG + +Q G GE+ E+ + ++ + G+ E + G
Sbjct: 182 EQEGQVREQEGQMGEQE-GQMGEQ--EEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGE 238
Query: 395 TDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRK----AEEERLRLEEE 450
+ + K + ++Q ++QEEQ R ++E+ E + LK+K EE+ EE+
Sbjct: 239 QEE-QVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQ 297
Query: 451 ARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEEL------LLKEKQEQEKQEKAM- 503
R+QEE+ + QEE+ ++Q EE+ + EE K EE++ + ++K++ KQE+ M
Sbjct: 298 MREQEEQMREQEEQMREQ--EEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMG 355
Query: 504 -IEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKK 562
E+Q + E + R+ EQMR + EQ+ Q EQ R + ++ ++ + + + Q+++
Sbjct: 356 EQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQ---KEQMGEQKEQMRE 412
Query: 563 EDPKVGVQ 570
++ ++G Q
Sbjct: 413 QEEQMGEQ 420
Score = 84.0 bits (206), Expect = 5e-16
Identities = 56/178 (31%), Positives = 106/178 (59%), Gaps = 15/178 (8%)
Query: 399 EAAKILAEKRRQARLQKEQEEQERVEKEEQDRL-EREELKRKAEEERLRLEEEARKQEEE 457
E + + E+ Q QKEQ EQE E+++++ E+EE R+ EE+ EE+ R+QEE+
Sbjct: 266 EQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQ 325
Query: 458 RKRQEE---EKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETK 514
+QEE E+K+Q E+K + ++ ++ E+E +++++EQ ++++ + KQ+E +
Sbjct: 326 MGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEE----Q 381
Query: 515 AREVAEQMRLEREQIMLQIEQ--ERLERKKRIDEIMKRTRKSDVPPQVKKEDPKVGVQ 570
R+ EQMR + EQ+ Q EQ E+ E+ + +E M ++ Q++K++ +G Q
Sbjct: 382 MRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKE-----QMRKQEEHMGEQ 434
Score = 81.6 bits (200), Expect = 2e-15
Identities = 70/262 (26%), Positives = 137/262 (52%), Gaps = 20/262 (7%)
Query: 335 EKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTAGT 394
E+E +E+EG + +Q + +E V ++ + G+ E + G
Sbjct: 154 EQEGQVREQEGQVREQEGQVREQEG---QVREQEGQVREQEGQMGEQEGQMGEQEEQMGE 210
Query: 395 TDAG--EAAKILAEKRRQARLQKEQ----EEQERVEKEEQDRLEREELKRKAEEERLRLE 448
+ + + + E+ Q R Q+EQ EEQ +K+E+ ++EE RK EE+ E
Sbjct: 211 QEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQV--QKQEEQVQKQEEQMRKQEEQMREQE 268
Query: 449 EEARKQEEERKRQEE--EKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEK 506
E+ R+QEE+ +Q+E E+++Q GE++ + E+ ++ E+E ++E++EQ ++++ + K
Sbjct: 269 EQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGK 328
Query: 507 QKEAA-ETKAR--EVAEQMRLEREQIMLQIEQ-ERLERKKRIDEIMKRTRKSDV---PPQ 559
Q+E E K + E EQM + EQ+ Q EQ ++ E + R E R ++ + Q
Sbjct: 329 QEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQ 388
Query: 560 VKKEDPKVGVQPAVCVEKKTKL 581
++K++ ++G Q E+K ++
Sbjct: 389 MRKQEEQMGEQKEQMGEQKEQM 410
Score = 81.3 bits (199), Expect = 3e-15
Identities = 59/218 (27%), Positives = 113/218 (51%), Gaps = 13/218 (5%)
Query: 326 GQDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSA 385
G+ + + ++E+ ++ E Q+ + EE + K E+ + E
Sbjct: 223 GEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMRE---QEEQML 279
Query: 386 ALGKPTAGTTDAGEAAKILAEKRRQARLQKEQ--EEQERVEKEEQDRLEREELKRKAEEE 443
+ T GE + + E+ Q R Q+EQ E++E++ ++E+ ++EE + +E+
Sbjct: 280 KQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQ 339
Query: 444 RLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAM 503
+E+ KQEE+ QEE+ +KQE + +++ EE RK EE+ + K++++ KQE+ M
Sbjct: 340 MWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQ--EEQMRKQEEQ-MRKQEEQMRKQEEQM 396
Query: 504 IEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERK 541
E++++ E K EQMR + EQ+ Q EQ R + +
Sbjct: 397 GEQKEQMGEQK-----EQMREQEEQMGEQKEQMRKQEE 429
Score = 80.9 bits (198), Expect = 4e-15
Identities = 53/182 (29%), Positives = 98/182 (53%), Gaps = 22/182 (12%)
Query: 333 KAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTA 392
+ ++E+ K++E T ++ G Q E+ E+ + E+ E +GK
Sbjct: 272 REQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGK--- 328
Query: 393 GTTDAGEAAKILAEKRRQARLQKEQ--EEQERVEKEEQDRLEREELKRKAEEERLRLEEE 450
+ Q QKEQ E++E++ K+E+ E+EE +K EE+ + EE+
Sbjct: 329 --------------QEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQ 374
Query: 451 ARKQEEERKRQEEEKKKQE---GEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQ 507
RKQEE+ ++QEE+ +KQE GE+K + GE+ ++ E+E + E++EQ ++++ + +Q
Sbjct: 375 MRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQ 434
Query: 508 KE 509
KE
Sbjct: 435 KE 436
Score = 75.9 bits (185), Expect = 1e-13
Identities = 49/162 (30%), Positives = 101/162 (62%), Gaps = 10/162 (6%)
Query: 407 KRRQARLQKEQ--EEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEE---ERKRQ 461
K+++ Q+EQ E++E++ ++E+ E+EE R+ EE+ EE+ KQEE E+K Q
Sbjct: 280 KQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQ 339
Query: 462 EEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQ 521
E+K+Q +++ + GE+ ++ ++E +++++EQ ++++ + KQ+E + R+ EQ
Sbjct: 340 MWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEE----QMRKQEEQ 395
Query: 522 MRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKE 563
M ++EQ+ Q EQ R E+++++ E ++ RK + +KE
Sbjct: 396 MGEQKEQMGEQKEQMR-EQEEQMGEQKEQMRKQEEHMGEQKE 436
Score = 70.5 bits (171), Expect = 5e-12
Identities = 63/265 (23%), Positives = 127/265 (47%), Gaps = 19/265 (7%)
Query: 335 EKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTAGT 394
E+E +E+EG + +Q G E+ + + E+ + + G+
Sbjct: 77 EQEGQVREQEGQVREQE-GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 135
Query: 395 TDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQ 454
E + E+ Q R Q+ Q ++ + EQ+ RE+ + E+E E+E +
Sbjct: 136 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMG 195
Query: 455 EEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQ-----EQEKQEKAMIEKQKE 509
E+E + E+E++ E EE+ + EE + EE++ +E+Q EQ ++++ ++KQ+E
Sbjct: 196 EQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEE 255
Query: 510 ---AAETKAREVAEQMRLEREQIMLQIEQ--------ERLERKKRIDEIMKRTRKS--DV 556
E + RE EQMR + EQ++ Q EQ E+ E+ + +E M+ + +
Sbjct: 256 QMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQ 315
Query: 557 PPQVKKEDPKVGVQPAVCVEKKTKL 581
Q+++++ ++G Q E+K ++
Sbjct: 316 EEQMREQEEQMGKQEEQMWEQKEQM 340
Score = 60.1 bits (144), Expect = 7e-09
Identities = 47/170 (27%), Positives = 92/170 (54%), Gaps = 9/170 (5%)
Query: 407 KRRQARLQKEQEEQERVEKEEQD-RLEREELKRKAEEERLRLEEE--ARKQEEERKRQEE 463
K + A LQ EE + VE E+ + +L +ELKRK E +++ L +E R+QE + + QE
Sbjct: 10 KEKNAELQ---EELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEG 66
Query: 464 EKKKQEGEEKRKAG---EEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAE 520
+ ++QEG+ + + G E+ + E+E ++E++ Q ++++ + +Q+ + +V E
Sbjct: 67 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 126
Query: 521 QMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKEDPKVGVQ 570
Q REQ EQE R++ + + + QV++++ +V Q
Sbjct: 127 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 176
Score = 52.0 bits (123), Expect = 2e-06
Identities = 39/149 (26%), Positives = 77/149 (51%), Gaps = 5/149 (3%)
Query: 399 EAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEER 458
E KI + Q R Q+ Q ++ + EQ+ RE+ + E+E E+E + +E+E
Sbjct: 42 ETDKIPLPQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 101
Query: 459 --KRQEEEKKKQEGEEKRKAG---EEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAET 513
+ QE + ++QEG+ + + G E+ + E+E ++E++ Q ++++ + +Q+
Sbjct: 102 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 161
Query: 514 KAREVAEQMRLEREQIMLQIEQERLERKK 542
+ +V EQ REQ EQE R++
Sbjct: 162 QEGQVREQEGQVREQEGQVREQEGQVREQ 190
Score = 49.3 bits (116), Expect = 1e-05
Identities = 31/136 (22%), Positives = 71/136 (52%), Gaps = 11/136 (8%)
Query: 25 GKIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRAR 84
G++ E Q + E + +E+ R +E+ E+E+ + +E+Q+ +++++ R
Sbjct: 199 GQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMR 258
Query: 85 LQYE---------KQMEERWRKLEEQRQREDQKRAAVEEKRKQ--KLREEEERLEAMMRR 133
Q E ++ EE+ K +EQ ++E+Q E+ R+Q ++RE+EE++ +
Sbjct: 259 KQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQ 318
Query: 134 SLERTQQLELKKKYSW 149
E+ +Q+ +++ W
Sbjct: 319 MREQEEQMGKQEEQMW 334
Score = 49.3 bits (116), Expect = 1e-05
Identities = 29/103 (28%), Positives = 63/103 (61%), Gaps = 9/103 (8%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQ-RQREDQK 108
K +E+ R +E+ E+E+ + +E+Q+L+++++ + EE+ + EEQ R++E+Q
Sbjct: 252 KQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQT------EQEEQTGEQEEQMREQEEQM 305
Query: 109 RAAVEEKRKQ--KLREEEERLEAMMRRSLERTQQLELKKKYSW 149
R E+ R+Q ++RE+EE++ + E+ +Q+ +K+ W
Sbjct: 306 REQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMW 348
Score = 48.5 bits (114), Expect = 2e-05
Identities = 33/121 (27%), Positives = 72/121 (59%), Gaps = 9/121 (7%)
Query: 29 EPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERRE-EREKCLAAREQQILEKQKRARLQY 87
+ G VR + R Q EG + E Q +E + E+E+ + +E+Q+ E++++ R Q
Sbjct: 176 QEGQVREQEGQVREQ--EGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQE 233
Query: 88 EK--QMEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKK 145
E+ + EE+ +K EEQ Q+++++ K+++++RE+EE++ + L++ +Q E ++
Sbjct: 234 EQMGEQEEQVQKQEEQVQKQEEQM----RKQEEQMREQEEQMREQEEQMLKQKEQTEQEE 289
Query: 146 K 146
+
Sbjct: 290 Q 290
Score = 48.1 bits (113), Expect = 3e-05
Identities = 35/125 (28%), Positives = 67/125 (53%), Gaps = 7/125 (5%)
Query: 25 GKIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRAR 84
G++ E Q + E + +E+ + +E+ E+E+ + +E+Q+ E++++ +
Sbjct: 185 GQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQ 244
Query: 85 LQYE--KQMEERWRKLEEQ-RQREDQKRAAVEEKRKQKLREEEE----RLEAMMRRSLER 137
Q E ++ EE+ RK EEQ R++E+Q R E+ KQK + E+E E MR E+
Sbjct: 245 KQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQ 304
Query: 138 TQQLE 142
++ E
Sbjct: 305 MREQE 309
Score = 47.0 bits (110), Expect = 6e-05
Identities = 33/108 (30%), Positives = 63/108 (58%), Gaps = 12/108 (11%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILE------KQKRARLQYEKQM---EERWR 96
E + +E+ R +E+ E+E+ + +E+Q+ E +QK + E+QM EE+ +
Sbjct: 303 EQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQ 362
Query: 97 KLEEQ-RQREDQKRAAVEEKRKQ--KLREEEERLEAMMRRSLERTQQL 141
K EEQ R++E+Q R E+ RKQ ++R++EE++ + E+ +Q+
Sbjct: 363 KQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQM 410
Score = 46.6 bits (109), Expect = 8e-05
Identities = 27/118 (22%), Positives = 68/118 (57%), Gaps = 5/118 (4%)
Query: 34 RTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYE---KQ 90
+T Q + E + +E+ R +E+ E+E+ + +E+Q+ +++++ Q E +Q
Sbjct: 284 QTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQ 343
Query: 91 MEERWRKLEEQRQREDQKRAAVEEKRKQ--KLREEEERLEAMMRRSLERTQQLELKKK 146
E+ W++ E+ ++E+Q + E+ RKQ ++R++EE++ + ++ +Q+ +K+
Sbjct: 344 KEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKE 401
Score = 44.3 bits (103), Expect = 4e-04
Identities = 32/109 (29%), Positives = 64/109 (58%), Gaps = 8/109 (7%)
Query: 46 EGFLKSDERQRLAKER-REEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQ-RQ 103
E K +E+ R +E+ RE+ E+ L +EQ E+Q + + ++ EE+ R+ EEQ R+
Sbjct: 255 EQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMRE 314
Query: 104 REDQKRAAVEE--KRKQKLREEEERL----EAMMRRSLERTQQLELKKK 146
+E+Q R E+ K+++++ E++E++ E M ++ + +Q E +K
Sbjct: 315 QEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQK 363
Score = 43.9 bits (102), Expect = 5e-04
Identities = 27/103 (26%), Positives = 66/103 (64%), Gaps = 5/103 (4%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYE--KQMEERWRKLEEQ-RQRED 106
K +E+ KE+ E+++ + +E+Q+ E++++ + Q E ++ EE+ RK EEQ R++E+
Sbjct: 328 KQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEE 387
Query: 107 QKRAAVEE--KRKQKLREEEERLEAMMRRSLERTQQLELKKKY 147
Q R E+ ++K+++ E++E++ + E+ +Q+ ++++
Sbjct: 388 QMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEH 430
Score = 43.1 bits (100), Expect = 0.001
Identities = 22/93 (23%), Positives = 60/93 (64%), Gaps = 5/93 (5%)
Query: 59 KERREEREKCLAAREQQILEKQKRARLQYE--KQMEERWRKLEEQRQREDQKRAAVEEK- 115
KE+ ++E+ + +E+Q+ +++++ R Q E ++ EE+ RK EEQ ++++++ +E+
Sbjct: 344 KEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQM 403
Query: 116 --RKQKLREEEERLEAMMRRSLERTQQLELKKK 146
+K+++RE+EE++ + ++ + + +K+
Sbjct: 404 GEQKEQMREQEEQMGEQKEQMRKQEEHMGEQKE 436
Score = 42.4 bits (98), Expect = 0.002
Identities = 29/119 (24%), Positives = 65/119 (54%), Gaps = 4/119 (3%)
Query: 29 EPGAVRTSQPNYRPQGMEGFLKSDERQRLAKE-RREEREKCLAAREQQILEKQKRARLQY 87
+ G VR + R Q EG ++ E Q +E + E+E+ + +E+Q ++KQ+ +
Sbjct: 169 QEGQVREQEGQVREQ--EGQVREQEGQMGEQEGQMGEQEEQMGEQEEQ-MQKQEEQMGEQ 225
Query: 88 EKQMEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
E+QM ++ ++ EQ ++ ++ V+++ +Q ++EE+ E + + Q L+ K++
Sbjct: 226 EEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQ 284
Score = 38.5 bits (88), Expect = 0.022
Identities = 33/131 (25%), Positives = 70/131 (53%), Gaps = 15/131 (11%)
Query: 29 EPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERR-EEREKCLAAREQQILEKQKRARLQ- 86
+ G VR + R Q EG ++ E Q +E + E+E + +E Q+ E++ + R Q
Sbjct: 134 QEGQVREQEGQVREQ--EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 191
Query: 87 -----YEKQM---EERWRKLEEQRQREDQKRAAVEE---KRKQKLREEEERLEAMMRRSL 135
E QM EE+ + EEQ Q+++++ EE K+++++ E+EE+++ +
Sbjct: 192 GQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQ 251
Query: 136 ERTQQLELKKK 146
++ +Q+ +++
Sbjct: 252 KQEEQMRKQEE 262
Score = 37.0 bits (84), Expect = 0.065
Identities = 26/123 (21%), Positives = 61/123 (49%), Gaps = 11/123 (8%)
Query: 29 EPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYE 88
+ G VR + R Q EG ++ E Q +E + ++ ++ + +Q+ + E
Sbjct: 148 QEGQVREQEGQVREQ--EGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQE 205
Query: 89 KQMEERWRKL---------EEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQ 139
+QM E+ ++ +E++ R+ +++ +E++ QK E+ ++ E MR+ E+ +
Sbjct: 206 EQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMR 265
Query: 140 QLE 142
+ E
Sbjct: 266 EQE 268
Score = 37.0 bits (84), Expect = 0.065
Identities = 19/87 (21%), Positives = 52/87 (59%), Gaps = 5/87 (5%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQRE 105
E K +E+ +E+ +++E+ + +E+Q+ +++++ R Q E+ ++ + E++ Q
Sbjct: 345 EQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMG 404
Query: 106 DQKRAAVEE-----KRKQKLREEEERL 127
+QK E+ ++K+++R++EE +
Sbjct: 405 EQKEQMREQEEQMGEQKEQMRKQEEHM 431
Score = 35.4 bits (80), Expect = 0.19
Identities = 37/141 (26%), Positives = 66/141 (46%), Gaps = 9/141 (6%)
Query: 430 RLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELL 489
R+ EELK K E L+EE + E E+ + K E KRK E K +E
Sbjct: 3 RITNEELKEKNAE----LQEELQLVETEKSEIQLHIK----ELKRKL-ETDKIPLPQEGQ 53
Query: 490 LKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMK 549
++E++ Q ++++ + +Q+ + +V EQ REQ EQE R++ +
Sbjct: 54 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 113
Query: 550 RTRKSDVPPQVKKEDPKVGVQ 570
+ + QV++++ +V Q
Sbjct: 114 EGQVREQEGQVREQEGQVREQ 134
Score = 34.3 bits (77), Expect = 0.42
Identities = 22/81 (27%), Positives = 46/81 (56%), Gaps = 4/81 (4%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQRE 105
E K +E+ R +E+ ++E+ + +E+Q + KQ+ + ++QM E+ E+ R++E
Sbjct: 359 EQMQKQEEQVRKQEEQMRKQEEQMRKQEEQ-MRKQEEQMGEQKEQMGEQK---EQMREQE 414
Query: 106 DQKRAAVEEKRKQKLREEEER 126
+Q E+ RKQ+ E++
Sbjct: 415 EQMGEQKEQMRKQEEHMGEQK 435
Score = 30.8 bits (68), Expect = 4.7
Identities = 16/68 (23%), Positives = 42/68 (61%), Gaps = 1/68 (1%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKR 109
K +E+ R +E+ ++E+ + +E+Q+ E QK + ++QM E+ ++ EQ+++ ++
Sbjct: 370 KQEEQMRKQEEQMRKQEEQMRKQEEQMGE-QKEQMGEQKEQMREQEEQMGEQKEQMRKQE 428
Query: 110 AAVEEKRK 117
+ E+++
Sbjct: 429 EHMGEQKE 436
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 84.0 bits (206), Expect = 5e-16
Identities = 90/357 (25%), Positives = 163/357 (45%), Gaps = 41/357 (11%)
Query: 327 QDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKH---------ASEKHAAAA 377
+D K K K K +E E Q+ + + E+ V ASE+ A
Sbjct: 243 RDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETP 302
Query: 378 GGKAENSAALGKPTAGTTDAGEAAKILAEKRR----------QARLQKEQEEQERVEKEE 427
+++ K GE + EK++ Q L K +EE+ER ++EE
Sbjct: 303 TAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREE 362
Query: 428 QDRLER-EELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEE 486
++R++R EEL+ K +EE RLE+E R+++++++++ +E+ K+EG+ K+ EA+ +AE
Sbjct: 363 EERIKRLEELEAKRKEEE-RLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEA 421
Query: 487 ELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDE 546
L L + Q E K + K++ E K R+ Q +LE +++ E +E + E
Sbjct: 422 TLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQ-QLESKEV-----SESMELCAAV-E 474
Query: 547 IMKR--TRKSDVPPQVK------KEDPKVGVQPAVCVEKKTKLVVPNKMEINGLNTCQEV 598
+M++ K + PP V+ ED + A+ +++T+ V NK+ I +E
Sbjct: 475 VMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEE- 533
Query: 599 NGVDHAAPETYPQDIFSNGLKPAGGLIHLDALDGKSNSLDDSTEEVQSMDVSPVSKE 655
+ E +D S + G D + + D + +++D P SKE
Sbjct: 534 ---EEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKP-SKE 586
Score = 65.1 bits (157), Expect = 2e-10
Identities = 71/295 (24%), Positives = 135/295 (45%), Gaps = 56/295 (18%)
Query: 303 QSPKTTKPPYPGSPVKYRLPALSGQD-------MPKR-KAEKEKSNKEREGTLAQQAAGP 354
+S KT KP ++ SG D +PK+ K + +KSNK+ +G+ +
Sbjct: 122 KSKKTAKP---------KVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSK 172
Query: 355 QGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKP----TAGTTDAGEAAKIL------ 404
+ +E + + E K + KP +G D + KI
Sbjct: 173 KIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKK 232
Query: 405 AEKRRQARLQKEQE--------EQERVEKEEQDRLEREELKRKAEEERLRLEEEARK--- 453
AEK+ + R ++++E E+E +E ++D+ +++E +RK EEE ++ +
Sbjct: 233 AEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVI 292
Query: 454 --QEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAA 511
EE+ + + EG++K+K ++ K+K E+E KEK++++ KA ++ +EA
Sbjct: 293 PASEEKAETPTAAEDDNEGDKKKK--DKKKKKGEKEE--KEKEKKKGPSKATVKAMQEAL 348
Query: 512 ETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKEDPK 566
K +E E+ + E E ER KR++E+ + ++ + Q K+E K
Sbjct: 349 -AKLKEEEERQKREEE-----------ERIKRLEELEAKRKEEERLEQEKRERKK 391
Score = 52.8 bits (125), Expect = 1e-06
Identities = 53/242 (21%), Positives = 107/242 (44%), Gaps = 23/242 (9%)
Query: 327 QDMPKRKAEKEKSNKER---EGTL---AQQAAGPQGEEALEK------HVVDKHASEKHA 374
Q+ +RK +KEK KER EG L +Q+ A + E L+ V K + K
Sbjct: 384 QEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKR 443
Query: 375 AAAGGKAENSAAL---GKPTAGTTDAGEAAKILAE---KRRQARLQKEQEEQERVEK--- 425
K K + + + A +++ + ++ + E EE+E E
Sbjct: 444 PIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGL 503
Query: 426 EEQDRLEREELKRKAEEERLRLE--EEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRK 483
++ + + +E K E ++ +E E ++EEE + +EE+++ +E EE+ E ++
Sbjct: 504 DDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGD 563
Query: 484 AEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKR 543
E+E + EK + +K ++ +E + + + ++ +IE+ RLE K
Sbjct: 564 EEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKN 623
Query: 544 ID 545
++
Sbjct: 624 VN 625
Score = 46.6 bits (109), Expect = 8e-05
Identities = 23/83 (27%), Positives = 46/83 (55%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKR 109
K E++ KE+++ K Q+ L K K + +++ EER ++LEE + ++
Sbjct: 321 KKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEE 380
Query: 110 AAVEEKRKQKLREEEERLEAMMR 132
+EKR++K ++E+ER E + +
Sbjct: 381 RLEQEKRERKKQKEKERKERLKK 403
Score = 42.7 bits (99), Expect = 0.001
Identities = 63/301 (20%), Positives = 121/301 (40%), Gaps = 43/301 (14%)
Query: 327 QDMPKRKAEKEKSNKEREGTLAQQAAGPQ---GEEALEKHVVD-------KHASEKHAAA 376
+D K + + E EG A + PQ G++ EK D K E A
Sbjct: 10 EDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEA 69
Query: 377 AGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQ--EEQERVEKEEQDRLERE 434
G KA+ KPT + E +K+++ + K+Q ++ + E E++D ++
Sbjct: 70 QGIKADRETVAVKPT----ENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKK 125
Query: 435 ELKRKAEE----------ERLRLEEEARKQEEERK---RQEEEKKKQEGEEKRKAGEEAK 481
K K E +L + + + Q+ +K +E+E ++ +E+ + +
Sbjct: 126 TAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGE 185
Query: 482 RKAEEELLLKEKQEQEKQEKAM----IEKQKEA--AETKAREVAEQMRLEREQIMLQIEQ 535
E + L+ ++ Q+K +K IE E A K + VA++ ++E+ + ++
Sbjct: 186 SGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDE 245
Query: 536 ERLERKKRIDEIMKRTRKSDVPPQVKKE--------DPKVGVQPAVCVEKKTKLVVPNKM 587
E+ + +K ++ T K D Q + + KV V V + K P
Sbjct: 246 EKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAA 305
Query: 588 E 588
E
Sbjct: 306 E 306
Score = 40.8 bits (94), Expect = 0.005
Identities = 30/113 (26%), Positives = 57/113 (50%), Gaps = 4/113 (3%)
Query: 34 RTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEE 93
+ P EG K ++++ K +EE+EK + K + L K+ EE
Sbjct: 298 KAETPTAAEDDNEGDKKKKDKKK-KKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEE 356
Query: 94 RWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
R ++ EE+R + ++ +E KRK++ R E+E+ E ++ ER ++L+ + K
Sbjct: 357 RQKREEEERIKRLEE---LEAKRKEEERLEQEKRERKKQKEKERKERLKKEGK 406
Score = 38.9 bits (89), Expect = 0.017
Identities = 41/200 (20%), Positives = 83/200 (41%), Gaps = 18/200 (9%)
Query: 327 QDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAA 386
+D ++K ++ +KE ++ AA E +E+ V +K + + A
Sbjct: 447 EDKKRKKIPQQLESKEVSESMELCAA----VEVMEQGVPEKEETPPPVEPEEEEDTEDAG 502
Query: 387 LGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLR 446
L A +D E+ + K E + +EE++ E EE ++EEE
Sbjct: 503 LDDWEAMASD---------EETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEE--- 550
Query: 447 LEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEK 506
EEE + E +E+EK E + + ++ ++ + ++ K+E+A +K
Sbjct: 551 -EEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERA-YDK 608
Query: 507 QKEAAETKAREVAEQMRLER 526
K E + E ++ + E+
Sbjct: 609 AKRRIEKRRLEHSKNVNTEK 628
Score = 38.1 bits (87), Expect = 0.029
Identities = 32/146 (21%), Positives = 66/146 (45%), Gaps = 49/146 (33%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILE-------KQKRARLQYEKQM----------- 91
K+++++R K+R EE+ K +E++ LE KQK ++ ++E++
Sbjct: 232 KAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGV 291
Query: 92 -----------------EERWRKLEEQRQREDQKRAAVEEKRK--------------QKL 120
E +K +++++++ +K +EK+K KL
Sbjct: 292 IPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKL 351
Query: 121 REEEERLEAMMRRSLERTQQLELKKK 146
+EEEER + ++R ++LE K+K
Sbjct: 352 KEEEERQKREEEERIKRLEELEAKRK 377
Score = 32.3 bits (72), Expect = 1.6
Identities = 24/101 (23%), Positives = 50/101 (49%), Gaps = 4/101 (3%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQRE 105
E K E + K EER K L E+ ++++ RL+ EK+ E + +K +E+++R
Sbjct: 346 EALAKLKEEEERQKREEEERIKRL---EELEAKRKEEERLEQEKR-ERKKQKEKERKERL 401
Query: 106 DQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
++ + + +++ E L+ + + +E + L KK
Sbjct: 402 KKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKK 442
Score = 30.0 bits (66), Expect = 8.0
Identities = 28/132 (21%), Positives = 62/132 (46%), Gaps = 4/132 (3%)
Query: 426 EEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAE 485
++Q + K + + L E E +E++ Q+ + KK++ ++K+ E+ K
Sbjct: 3 KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKEL 62
Query: 486 EELLLKEKQ-EQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRI 544
EEL L+ + + +++ A+ + E +++ ++ + ++Q + E LE K
Sbjct: 63 EELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDK--- 119
Query: 545 DEIMKRTRKSDV 556
D K+T K V
Sbjct: 120 DSKSKKTAKPKV 131
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 82.8 bits (203), Expect = 1e-15
Identities = 50/159 (31%), Positives = 99/159 (62%), Gaps = 7/159 (4%)
Query: 406 EKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQE-EE 464
+K R++ +KE+ E+E+ ++E + +RE K++ + ER + E E +K+ E++ +E EE
Sbjct: 52 KKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEE 111
Query: 465 KKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRL 524
K+K++ +EK++ G +K E E K+E++++E+ E++KE E K RE E+ +
Sbjct: 112 KEKRKKKEKKERGRTSKEGKERE----RKEERKREERKERERKKEERE-KERERKERKKR 166
Query: 525 EREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKE 563
ER+Q+ + E+ER E++++ + +R RK + +KE
Sbjct: 167 ERKQVG-EKEEERKEKERKERKKRERNRKERKKERERKE 204
Score = 80.9 bits (198), Expect = 4e-15
Identities = 57/213 (26%), Positives = 112/213 (52%), Gaps = 22/213 (10%)
Query: 331 KRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKP 390
+R++E++K +ERE ++ + E ++ ++ E+ + EN
Sbjct: 54 ERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENK------ 107
Query: 391 TAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEE-ERLRLEE 449
GE + +K ++ R + +E +ER KEE+ R ER+E +RK EE E+ R +
Sbjct: 108 ------EGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERK 161
Query: 450 EARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKE 509
E +K+E ++ ++EE++K++ ++RK E +++ ++E KE++E++K+ K E++KE
Sbjct: 162 ERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKE 221
Query: 510 AAETKAREVAEQMRLEREQIMLQIEQERLERKK 542
+ + E+ R +R ER ERKK
Sbjct: 222 RQKDRQTNWREKERGKR---------ERKERKK 245
Score = 80.9 bits (198), Expect = 4e-15
Identities = 49/191 (25%), Positives = 100/191 (52%), Gaps = 10/191 (5%)
Query: 327 QDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAA 386
++ KRK E+EK K G ++ GE E+ K EK K +
Sbjct: 64 REREKRKREREKERKRERGKKEKK-----GERKKEERERKKRRREKENKEGEEKEKRKKK 118
Query: 387 LGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLR 446
K T+ G+ + E++R+ R ++E++++ER ++ E+ ++ E K+ E+E R
Sbjct: 119 EKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEER 178
Query: 447 LEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEK 506
E+E +++++ + ++E KK++E +E+R+ +E K+K E ++K+ Q+ ++ EK
Sbjct: 179 KEKERKERKKRERNRKERKKERERKERRERKKERKKKEE-----RKKERQKDRQTNWREK 233
Query: 507 QKEAAETKARE 517
++ E K R+
Sbjct: 234 ERGKRERKERK 244
Score = 80.1 bits (196), Expect = 7e-15
Identities = 58/213 (27%), Positives = 108/213 (50%), Gaps = 9/213 (4%)
Query: 332 RKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPT 391
R+ E+E + +EG +++ + EK K EK GK E K
Sbjct: 39 REREREIETR-KEGKKERESERKKERREREKR---KREREKERKRERGKKEKKGERKKEE 94
Query: 392 AGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEA 451
+ + ++ R +KE++E+ R KE ++R +EE KR+ +ER R +EE
Sbjct: 95 RERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEER 154
Query: 452 RKQEEERKRQEEEKKK-QEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEA 510
K+ E ++R++ E+K+ E EE+RK E +RK E + K+E+E++E+ +K+++
Sbjct: 155 EKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKK 214
Query: 511 AETKAREVAEQMRLEREQIMLQIEQERLERKKR 543
E + +E + +R+ + E+ + ERK+R
Sbjct: 215 KEERKKE----RQKDRQTNWREKERGKRERKER 243
Score = 79.0 bits (193), Expect = 1e-14
Identities = 52/154 (33%), Positives = 96/154 (62%), Gaps = 8/154 (5%)
Query: 406 EKRRQARLQKEQEEQERVEKE-EQDRLEREELKRKAEEERLRLEEE---ARKQEEERKRQ 461
EKR++ R ++ + E+ + EK+ E+ + ERE KR+ E+E EE+ +K+++ER R
Sbjct: 67 EKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRT 126
Query: 462 EEEKKKQEGEEKRKAGE--EAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVA 519
+E K++E +E+RK E E +RK EE +E++E++K+E+ + +++E E K +E
Sbjct: 127 SKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEE--ERKEKERK 184
Query: 520 EQMRLEREQIMLQIEQERLERKKRIDEIMKRTRK 553
E+ + ER + + E+ER ER++R E K+ +
Sbjct: 185 ERKKRERNRKERKKERERKERRERKKERKKKEER 218
Score = 75.5 bits (184), Expect = 2e-13
Identities = 47/157 (29%), Positives = 92/157 (58%), Gaps = 9/157 (5%)
Query: 406 EKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEK 465
EK+ + + ++ + ++ R EKE ++ E+E+ K+K ++ER R +E +++E + +R+ EE+
Sbjct: 85 EKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREER 144
Query: 466 KKQE--GEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEA-AETKAREVAEQM 522
K++E EE+ K E +RK E + EK+E+ K+++ K++E + + +E +
Sbjct: 145 KERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKE 204
Query: 523 RLEREQIMLQIEQERLERKK------RIDEIMKRTRK 553
R ER++ + E+ + ER+K R E KR RK
Sbjct: 205 RRERKKERKKKEERKKERQKDRQTNWREKERGKRERK 241
Score = 72.0 bits (175), Expect = 2e-12
Identities = 56/168 (33%), Positives = 96/168 (57%), Gaps = 19/168 (11%)
Query: 414 QKEQEEQER-VEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEE 472
Q E E+ER +E ++ + ERE ++K ER E+ R++E+ERKR E KK+++GE
Sbjct: 35 QSEIREREREIETRKEGKKERESERKKERRER---EKRKREREKERKR-ERGKKEKKGER 90
Query: 473 KRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQ 532
K++ E KR+ E+E KE +E+EK++K K+K+ ++E E+ R E
Sbjct: 91 KKEERERKKRRREKE--NKEGEEKEKRKK----KEKKERGRTSKEGKERERKE------- 137
Query: 533 IEQERLERKKRIDEIMKRTRKSDVPPQVKKEDPKVGVQPAVCVEKKTK 580
E++R ERK+R + +R ++ + + K+E +VG + EK+ K
Sbjct: 138 -ERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERK 184
Score = 50.1 bits (118), Expect = 7e-06
Identities = 30/101 (29%), Positives = 63/101 (62%), Gaps = 4/101 (3%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQRE 105
+G K +ER+R K+RR E+E +++ +K+K+ R + K+ +ER RK E+R+RE
Sbjct: 87 KGERKKEERER--KKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERK--EERKRE 142
Query: 106 DQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
++K +++ ++K RE +ER + ++ E+ ++ + K++
Sbjct: 143 ERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKER 183
Score = 47.8 bits (112), Expect = 4e-05
Identities = 30/110 (27%), Positives = 62/110 (56%), Gaps = 11/110 (10%)
Query: 43 QGMEGFLKSDERQRLAKER---REEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLE 99
+G E K + ++ KER +EEREK E++ E++KR R Q ++ EER K
Sbjct: 129 EGKERERKEERKREERKERERKKEEREK-----ERERKERKKRERKQVGEKEEERKEKER 183
Query: 100 EQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
++R++ ++ R +E++K++ R+E + ++ ER ++ + ++ +W
Sbjct: 184 KERKKRERNR---KERKKERERKERRERKKERKKKEERKKERQKDRQTNW 230
Score = 46.6 bits (109), Expect = 8e-05
Identities = 29/94 (30%), Positives = 54/94 (57%), Gaps = 4/94 (4%)
Query: 53 ERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAV 112
ER R +KE +E K RE++ ++++R + + EK+ E + RK E++Q +++
Sbjct: 122 ERGRTSKEGKERERKEERKREER--KERERKKEEREKERERKERKKRERKQVGEKEEERK 179
Query: 113 EEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
E++RK++ + E R E R ER ++ E KK+
Sbjct: 180 EKERKERKKRERNRKERKKER--ERKERRERKKE 211
Score = 46.6 bits (109), Expect = 8e-05
Identities = 25/94 (26%), Positives = 55/94 (58%), Gaps = 4/94 (4%)
Query: 53 ERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAV 112
E++R KER++ K + +E++ EK+++ R + E+ +ER ++ E + +RE +K
Sbjct: 155 EKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKK---- 210
Query: 113 EEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
E K+K++ ++E ++ R ER ++ ++K
Sbjct: 211 ERKKKEERKKERQKDRQTNWREKERGKRERKERK 244
Score = 46.2 bits (108), Expect = 1e-04
Identities = 30/94 (31%), Positives = 54/94 (57%), Gaps = 5/94 (5%)
Query: 53 ERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAV 112
ER+ K+ R EREK RE++ +KR R + EK+ E + + E +++R +++
Sbjct: 54 ERESERKKERREREKRKREREKE----RKRERGKKEKKGERKKEERERKKRRREKENKEG 109
Query: 113 EEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
EEK K+K +E++ER + ER ++ E K++
Sbjct: 110 EEKEKRKKKEKKER-GRTSKEGKERERKEERKRE 142
Score = 45.4 bits (106), Expect = 2e-04
Identities = 30/98 (30%), Positives = 59/98 (60%), Gaps = 6/98 (6%)
Query: 52 DERQRLAKERREEREKCLAAREQQILEKQKR-ARLQYEKQMEERWRKLE--EQRQREDQK 108
++ +R KE++E +E++ E++KR R + E++ EER ++ E E+++RE ++
Sbjct: 111 EKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQ 170
Query: 109 RAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
EE+RK+K R+E ++ E R ER ++ E K++
Sbjct: 171 VGEKEEERKEKERKERKKRE---RNRKERKKERERKER 205
Score = 44.7 bits (104), Expect = 3e-04
Identities = 29/96 (30%), Positives = 54/96 (56%), Gaps = 6/96 (6%)
Query: 50 KSDERQRLAKE-----RREEREKCLAAREQQILE-KQKRARLQYEKQMEERWRKLEEQRQ 103
K +R+R KE ++EERE+ RE++ E ++K R + EK+ R K ++R+
Sbjct: 75 KERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERE 134
Query: 104 REDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQ 139
R+++++ ++R++K E E+ E R+ ER Q
Sbjct: 135 RKEERKREERKERERKKEEREKERERKERKKRERKQ 170
Score = 43.5 bits (101), Expect = 7e-04
Identities = 25/97 (25%), Positives = 57/97 (58%), Gaps = 1/97 (1%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKR 109
+ + ++ KE+R+++EK R + ++++R + ++ +ER RK +E+R++E +++
Sbjct: 103 EKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERK-KEEREKERERK 161
Query: 110 AAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
+ +RKQ +EEER E + +R + + +KK
Sbjct: 162 ERKKRERKQVGEKEEERKEKERKERKKRERNRKERKK 198
Score = 42.7 bits (99), Expect = 0.001
Identities = 26/95 (27%), Positives = 54/95 (56%), Gaps = 2/95 (2%)
Query: 53 ERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERW-RKLEEQRQREDQKRAA 111
ER++ K R ++EK R+++ E++KR R + K+ EE+ RK +E+++R +
Sbjct: 72 EREKERKRERGKKEK-KGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEG 130
Query: 112 VEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
E +RK++ + EE + + E+ ++ + +KK
Sbjct: 131 KERERKEERKREERKERERKKEEREKERERKERKK 165
Score = 42.0 bits (97), Expect = 0.002
Identities = 24/97 (24%), Positives = 52/97 (53%), Gaps = 4/97 (4%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKR 109
K + R+R ++R E+E+ + ++ +++K R + E++ ++R R+ E + E +KR
Sbjct: 60 KKERREREKRKREREKER----KRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKR 115
Query: 110 AAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
E+K + + +E + E R E ++ E KK+
Sbjct: 116 KKKEKKERGRTSKEGKERERKEERKREERKERERKKE 152
Score = 41.2 bits (95), Expect = 0.003
Identities = 24/89 (26%), Positives = 53/89 (59%), Gaps = 4/89 (4%)
Query: 52 DERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAA 111
+ ++R +ER++ EK +E++ E++KR R + E++ +ER RK +R++E +K+
Sbjct: 159 ERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERK-KERERKERRERKKERKKK-- 215
Query: 112 VEEKRKQKLREEEERLEAMMRRSLERTQQ 140
EE++K++ ++ + R ER ++
Sbjct: 216 -EERKKERQKDRQTNWREKERGKRERKER 243
Score = 40.4 bits (93), Expect = 0.006
Identities = 23/74 (31%), Positives = 43/74 (58%), Gaps = 2/74 (2%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKR 109
K +ER+ ++ R++RE+ R+++ K++R R + K+ EE RK E Q+ R+ R
Sbjct: 174 KEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEE--RKKERQKDRQTNWR 231
Query: 110 AAVEEKRKQKLREE 123
KR++K R++
Sbjct: 232 EKERGKRERKERKK 245
Score = 35.4 bits (80), Expect = 0.19
Identities = 23/87 (26%), Positives = 49/87 (56%), Gaps = 2/87 (2%)
Query: 64 EREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKLREE 123
ERE+ + R++ E++ R + ++ E+R R+ E++R+RE K+ E++K++ RE
Sbjct: 40 EREREIETRKEGKKERESE-RKKERREREKRKREREKERKRERGKKEKKGERKKEE-RER 97
Query: 124 EERLEAMMRRSLERTQQLELKKKYSWG 150
++R + E ++ + K+K G
Sbjct: 98 KKRRREKENKEGEEKEKRKKKEKKERG 124
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 82.4 bits (202), Expect = 1e-15
Identities = 56/186 (30%), Positives = 107/186 (57%), Gaps = 6/186 (3%)
Query: 402 KILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQ 461
K+ +++R +KE EQE+ +E++ E+EE ++ EE+ EE+ R+QEE+ RQ
Sbjct: 277 KMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQ 336
Query: 462 EE---EKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQ-EKQEKAMIEKQKEAAETKARE 517
EE E++KQ E+++K ++ +R E++ L+EK+E+ +QEK +++K E + RE
Sbjct: 337 EERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRE 396
Query: 518 VAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKK--EDPKVGVQPAVCV 575
++MR E E + Q E+ + + + ++ K ++ +P Q +K E K+ Q
Sbjct: 397 REKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIW 456
Query: 576 EKKTKL 581
E++ K+
Sbjct: 457 EQEEKI 462
Score = 79.0 bits (193), Expect = 1e-14
Identities = 48/168 (28%), Positives = 99/168 (58%), Gaps = 9/168 (5%)
Query: 402 KILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLR-----LEEEARKQEE 456
KI ++ + R ++ EQE +E+++++ R+E + + +E+ LR L E+ + +E+
Sbjct: 249 KIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQ 308
Query: 457 ERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKE-AAETKA 515
E + QE+E+K E EEK + EE + EE L +EKQ +E+++K ++++ + +
Sbjct: 309 EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERL 368
Query: 516 REVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKE 563
RE E+M REQ + ++E+++ ++RI E K+ R+ + + ++E
Sbjct: 369 REKEERM---REQEKMWEQEEKMQEEERIREREKKMREEEETMREQEE 413
Score = 78.6 bits (192), Expect = 2e-14
Identities = 79/307 (25%), Positives = 139/307 (45%), Gaps = 49/307 (15%)
Query: 328 DMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAAL 387
D +R E+++ +E+E + +Q Q EE + + + +K
Sbjct: 504 DQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKK--------------- 548
Query: 388 GKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRL 447
T D E K+ E+R + R +K +EE+E + ++E+ E+EE R+ EE+
Sbjct: 549 ------TWDQEE--KMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQ 600
Query: 448 EEEARKQEEERKRQEE---------------------EKKKQEGEEKRKAGEEAKRKAEE 486
EE+ ++QEE+ QEE E+K QE EEK EE R+ EE
Sbjct: 601 EEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEE 660
Query: 487 ELLLKEKQEQEKQEKAMIEKQK-EAAETKAREVAEQMRLEREQIMLQIEQERLERKKRID 545
++ +E++ Q ++EK +++K + E K RE E+MR + E++ Q E+ + +K
Sbjct: 661 KMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWG 720
Query: 546 EIMKRTRKSDVPPQVKKEDPKVGVQPAVCVEKKTKLVVPNKMEINGLNTCQEVNGVDHAA 605
+ R ++ + Q +K ++ C E + P+K+ N +T V A
Sbjct: 721 QEEMREKEERIRDQKEKMQERLPEHEERCSE---PCLPPSKVLCNMSHT-GSVEPAGGEA 776
Query: 606 PETYPQD 612
E PQD
Sbjct: 777 GEGSPQD 783
Score = 77.4 bits (189), Expect = 4e-14
Identities = 63/239 (26%), Positives = 128/239 (53%), Gaps = 18/239 (7%)
Query: 323 ALSGQDMPKRKAEK--EKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGK 380
ALS +KA++ E+ KER+ + E L+K + EK A K
Sbjct: 146 ALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKK--NAELQEKLRLAESEK 203
Query: 381 AE---NSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELK 437
+E N L + E AK L + + LQ+E QE +E++ ++ ++E K
Sbjct: 204 SEIQLNVKELKRKL-------ERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEK 256
Query: 438 RKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQE 497
+EERLR +E +++EE+ R++E++ +++ +E R E+ K E++ L +++++ +
Sbjct: 257 MWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELR---EQEKELREQKKLREQEEQMQ 313
Query: 498 KQEKAMIEKQKEAAETKAREVAEQMRL-EREQIMLQIEQERLERKKRIDEIMKRTRKSD 555
+QE+ M E++++ E + + ++ RL E+E+ M + EQ+ ++++R+ E +R R+ +
Sbjct: 314 EQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKE 372
Score = 74.3 bits (181), Expect = 4e-13
Identities = 45/160 (28%), Positives = 95/160 (59%), Gaps = 5/160 (3%)
Query: 407 KRRQARLQKEQEEQERVEKE--EQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEE 464
+ ++ ++++++E+ R EK EQ++ RE+ K E+++LR E+E + QE+E K E+E
Sbjct: 265 REQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLR-EQEEQMQEQEEKMWEQE 323
Query: 465 KKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRL 524
+K +E EEK EE R E+E ++E++++ + ++ + +Q E K + EQ ++
Sbjct: 324 EKMREQEEKMWRQEE--RLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKM 381
Query: 525 EREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKED 564
++ +Q E+ ER+K++ E + R+ + Q ++E+
Sbjct: 382 WEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEEN 421
Score = 74.3 bits (181), Expect = 4e-13
Identities = 60/241 (24%), Positives = 120/241 (49%), Gaps = 19/241 (7%)
Query: 331 KRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKA--------E 382
KR E+EK +E+E L +Q + EE +++ E+ K E
Sbjct: 283 KRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWE 342
Query: 383 NSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERV-----EKEEQDRLEREELK 437
+ + D E ++ + R ++ EQE++ + +E++R+ E K
Sbjct: 343 QEKQMREQEQKMRDQEE--RMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKK 400
Query: 438 RKAEEERLRLEEEARKQEEERKRQEEEKKKQE---GEEKRKAGEEAKRKAEEELLLKEKQ 494
+ EEE +R +EE +++EE ++EEK+ Q+ E+K K E+ K + +EE + ++++
Sbjct: 401 MREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEE 460
Query: 495 EQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKS 554
+ QE+ +++K + K RE +QM E+E+ M EQ+ ++++R+ E +R R+
Sbjct: 461 KIRDQEEMWGQEKKMWRQEKMREQEDQM-WEQEEKMRDQEQKMWDQEERMWEQDERLREK 519
Query: 555 D 555
+
Sbjct: 520 E 520
Score = 73.6 bits (179), Expect = 6e-13
Identities = 44/174 (25%), Positives = 101/174 (58%), Gaps = 4/174 (2%)
Query: 399 EAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEER 458
E K L E+ ++ R QK+ EQE +E+++++ +E K + +EE++ +EE ++E++
Sbjct: 287 EQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ 346
Query: 459 KRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREV 518
R++E+K + +E+R ++ + + +EE + ++++ E++EK E++ E K RE
Sbjct: 347 MREQEQKMRD--QEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREE 404
Query: 519 AEQMRLEREQIMLQIEQ--ERLERKKRIDEIMKRTRKSDVPPQVKKEDPKVGVQ 570
E MR + E++ Q E E+ E++ + + ++ K ++++++ K+ Q
Sbjct: 405 EETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQ 458
Score = 72.4 bits (176), Expect = 1e-12
Identities = 61/266 (22%), Positives = 135/266 (50%), Gaps = 17/266 (6%)
Query: 331 KRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKA-------EN 383
+R E+EK +E E T+ +Q Q +E +K ++ K E
Sbjct: 392 ERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ 451
Query: 384 SAALGKPTAGTTDA----GEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRK 439
+ + D G+ K+ +++ + + + E++E++ +EQ ++EE +
Sbjct: 452 EEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEE-RMW 510
Query: 440 AEEERLRLEEEARKQEEERKRQEE---EKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQ 496
++ERLR +EE +++++ +QEE E+KK + +EK+ +E K + EE + +EK+ +
Sbjct: 511 EQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMR 570
Query: 497 EKQEKAMIEKQK-EAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSD 555
E++E +++K + E K RE E+M E+E+ M + E++ E+++++ E + + +
Sbjct: 571 EEEEMMREQEEKMQEQEEKMREQEEKM-WEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQE 629
Query: 556 VPPQVKKEDPKVGVQPAVCVEKKTKL 581
+ +++ K+ Q E++ K+
Sbjct: 630 QEEMMWEQEEKMQEQEEKMWEQEEKM 655
Score = 70.1 bits (170), Expect = 7e-12
Identities = 59/203 (29%), Positives = 108/203 (53%), Gaps = 29/203 (14%)
Query: 407 KRRQARLQKEQEEQERVEKEEQDRLEREELKRKAE---------------EERLRLEEEA 451
K++ A LQ++ E + E Q L +ELKRK E EE R EEE
Sbjct: 186 KKKNAELQEKLRLAESEKSEIQ--LNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEEL 243
Query: 452 RKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAA 511
R+QE++ ++QEE+ +Q E+R +E K + +EE + ++++ +QEK + E++KE
Sbjct: 244 REQEKKIRKQEEKMWRQ---EERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELR 300
Query: 512 E-TKAREVAEQMR------LEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKED 564
E K RE EQM+ E+E+ M + E++ +++R+ E K+ R+ + +++ ++
Sbjct: 301 EQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQE--QKMRDQE 358
Query: 565 PKVGVQPAVCVEKKTKLVVPNKM 587
++ Q EK+ ++ KM
Sbjct: 359 ERMWEQDERLREKEERMREQEKM 381
Score = 67.0 bits (162), Expect = 6e-11
Identities = 59/260 (22%), Positives = 132/260 (50%), Gaps = 15/260 (5%)
Query: 331 KRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKP 390
K + ++EK ++ E Q+ + EE + + EK + L +
Sbjct: 249 KIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQ 308
Query: 391 TAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEE 450
+ E EK R+ + ++E+ E+E+Q R +E K + +EER+ ++E
Sbjct: 309 EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMR--EQEQKMRDQEERMWEQDE 366
Query: 451 ARKQEEERKRQEE-----EKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIE 505
+++EER R++E E+K QE E R+ E K + EEE + +++++ +KQE+ M E
Sbjct: 367 RLREKEERMREQEKMWEQEEKMQEEERIRE--REKKMREEEETMREQEEKMQKQEENMWE 424
Query: 506 KQKEAAETKAREVAEQMRLEREQIMLQIEQERL-ERKKRI---DEIMKRTRKSDVPPQVK 561
++++ E + + + EQ EQ +Q ++E++ E++++I +E+ + +K +++
Sbjct: 425 QEEK--EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMR 482
Query: 562 KEDPKVGVQPAVCVEKKTKL 581
+++ ++ Q +++ K+
Sbjct: 483 EQEDQMWEQEEKMRDQEQKM 502
Score = 66.6 bits (161), Expect = 8e-11
Identities = 58/265 (21%), Positives = 134/265 (50%), Gaps = 18/265 (6%)
Query: 327 QDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAA 386
+D +R E+++ +E+E + +Q + EE +++ + +K E
Sbjct: 355 RDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEK 414
Query: 387 LGKPTAGTTDAGEAA------KILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKA 440
+ K + E EK + +EQE E++ ++E+ ++EE+
Sbjct: 415 MQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQE--EKIWEQEEKIRDQEEM--WG 470
Query: 441 EEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQE 500
+E+++ +E+ R+QE++ QEE+ + QE +K ++ +R E++ L+EK+E+ +++
Sbjct: 471 QEKKMWRQEKMREQEDQMWEQEEKMRDQE----QKMWDQEERMWEQDERLREKEERMREQ 526
Query: 501 KAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQER-LERKKRIDEIMKRTRKSDVPPQ 559
K M +++++ E K + E+ ++E+ M + E+ R E+K R +E M R ++ + Q
Sbjct: 527 KKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQ 586
Query: 560 ---VKKEDPKVGVQPAVCVEKKTKL 581
+++++ K+ Q E++ K+
Sbjct: 587 EEKMREQEEKMWEQEEKMQEQEEKM 611
Score = 66.2 bits (160), Expect = 1e-10
Identities = 64/243 (26%), Positives = 121/243 (49%), Gaps = 20/243 (8%)
Query: 324 LSGQDMPKRKAEK-----EKSNKEREGTLAQQAAGPQGEEA-LEKHVVDKHASEKHAAAA 377
L Q+ RK E+ E+ +E+EG + +Q + +E L + + EK
Sbjct: 243 LREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQ 302
Query: 378 GGKAENSAALGKPTAGTTDAGEAAKILAEK--RRQARL-----QKEQEEQERVEKE---- 426
E + + + E + EK R++ RL Q ++EQ+ ++E
Sbjct: 303 KKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMW 362
Query: 427 EQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEE 486
EQD RE+ +R E+E++ E+E + QEEER R+ E+K ++E E R+ +E K + +E
Sbjct: 363 EQDERLREKEERMREQEKM-WEQEEKMQEEERIREREKKMREEEETMRE--QEEKMQKQE 419
Query: 487 ELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDE 546
E + ++++++ +Q++ +K+K + K +E E++ + E+I Q E E+K E
Sbjct: 420 ENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQE 479
Query: 547 IMK 549
M+
Sbjct: 480 KMR 482
Score = 50.4 bits (119), Expect = 6e-06
Identities = 27/108 (25%), Positives = 62/108 (57%), Gaps = 6/108 (5%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQRE 105
E + DER R +ER E++K E+ + ++K+ + Q +K ++ + EE+R RE
Sbjct: 507 ERMWEQDERLREKEERMREQKKMWQQEEK--MREEKKTQEQEKKTWDQEEKMREEERMRE 564
Query: 106 DQKRAAVEE----KRKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
+K+ EE ++++K++E+EE++ + E+ ++++ +++ W
Sbjct: 565 REKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMW 612
Score = 49.7 bits (117), Expect = 1e-05
Identities = 28/97 (28%), Positives = 58/97 (59%), Gaps = 6/97 (6%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKR 109
K +E+ +ER E+E + +E+++ ++KR R Q EK++ E+ ++L EQ++ +Q+
Sbjct: 252 KQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQ-EKELREQEKELREQKKLREQEE 310
Query: 110 AAVEEKRK-----QKLREEEERLEAMMRRSLERTQQL 141
E++ K +K+RE+EE++ R E+ +Q+
Sbjct: 311 QMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQM 347
Score = 49.3 bits (116), Expect = 1e-05
Identities = 22/97 (22%), Positives = 55/97 (56%)
Query: 53 ERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAV 112
E + +ER EREK + E+ + E++++ + Q EK E+ + E++ + ++Q+
Sbjct: 553 EEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMW 612
Query: 113 EEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
E++ K +EEE++++ E+ ++++ +++ W
Sbjct: 613 EQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMW 649
Score = 49.3 bits (116), Expect = 1e-05
Identities = 25/124 (20%), Positives = 69/124 (55%), Gaps = 6/124 (4%)
Query: 33 VRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQME 92
++ + R Q + + + ++ Q ++ E+ EK E+ +++Q+ + E++M+
Sbjct: 583 MQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQ 642
Query: 93 ER----WRKLEEQRQREDQKRAAVE--EKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
E+ W + E+ R++E++ R E + +++K+RE+EE+++ + E+ +++ +++
Sbjct: 643 EQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEE 702
Query: 147 YSWG 150
WG
Sbjct: 703 KMWG 706
Score = 48.9 bits (115), Expect = 2e-05
Identities = 31/109 (28%), Positives = 64/109 (58%), Gaps = 6/109 (5%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEE--RWRKLEEQRQ 103
E + +ER R + + E+E+ + +E+++ E++K R Q EK++ E + R+ EEQ Q
Sbjct: 255 EKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQ-EKELREQKKLREQEEQMQ 313
Query: 104 REDQKRAAVEEK---RKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
+++K EEK +++K+ +EERL ++ E+ Q++ +++ W
Sbjct: 314 EQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMW 362
Score = 48.5 bits (114), Expect = 2e-05
Identities = 29/112 (25%), Positives = 63/112 (56%), Gaps = 6/112 (5%)
Query: 34 RTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEE 93
+T + + E ++ +ER R +++ E E+ + +E+++ E++++ R Q EK E+
Sbjct: 541 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQ 600
Query: 94 RWRKLEEQRQRE-DQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELK 144
K++EQ ++ +Q+ E++ + K++E+EE MM E+ Q+ E K
Sbjct: 601 E-EKMQEQEEKMWEQEEKMWEQEEEDKMQEQEE----MMWEQEEKMQEQEEK 647
Score = 48.5 bits (114), Expect = 2e-05
Identities = 31/121 (25%), Positives = 65/121 (53%), Gaps = 4/121 (3%)
Query: 26 KIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARL 85
K+ E + Q + E + +E+ R +E+ E+E+ + +E+++ E++++ +
Sbjct: 626 KMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQG 685
Query: 86 QYEK--QMEERWRKLEEQRQREDQKRAAVEEKR--KQKLREEEERLEAMMRRSLERTQQL 141
Q EK + EE+ R EE+ +++K EEK ++++RE+EER+ + ER +
Sbjct: 686 QEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEH 745
Query: 142 E 142
E
Sbjct: 746 E 746
Score = 48.1 bits (113), Expect = 3e-05
Identities = 30/103 (29%), Positives = 66/103 (64%), Gaps = 8/103 (7%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKL--EEQRQREDQ 107
+ +E+ R ++R E+EK L +E+++ E QK+ R Q E+QM+E+ K+ +E++ RE +
Sbjct: 273 EQEEKMRRQEKRLREQEKELREQEKELRE-QKKLREQ-EEQMQEQEEKMWEQEEKMREQE 330
Query: 108 KRAAVEEKR----KQKLREEEERLEAMMRRSLERTQQLELKKK 146
++ +E+R ++++RE+E+++ R E+ ++L K++
Sbjct: 331 EKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEE 373
Score = 47.8 bits (112), Expect = 4e-05
Identities = 35/123 (28%), Positives = 64/123 (52%), Gaps = 7/123 (5%)
Query: 29 EPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYE 88
+ G +R + R Q E L+ E++ +E+ +K L +E+Q+ E++++ Q E
Sbjct: 267 QEGKMREQEEKMRRQ--EKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEE 324
Query: 89 K---QMEERWRKLEEQRQREDQKRAAVEEKRKQKLR--EEEERLEAMMRRSLERTQQLEL 143
K Q E+ WR+ E ++E Q R ++ R Q+ R E++ERL R E+ + E
Sbjct: 325 KMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQ 384
Query: 144 KKK 146
++K
Sbjct: 385 EEK 387
Score = 47.4 bits (111), Expect = 5e-05
Identities = 31/114 (27%), Positives = 61/114 (53%), Gaps = 10/114 (8%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLE-EQRQR 104
E + +E+ R +E+ +E+ L +E+Q+ E++++ R Q E+ E+ R E E+R R
Sbjct: 317 EKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMR 376
Query: 105 EDQKRAAVEEK---------RKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
E +K EEK R++K+REEEE + + ++ + + +++ W
Sbjct: 377 EQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEW 430
Score = 47.4 bits (111), Expect = 5e-05
Identities = 24/97 (24%), Positives = 61/97 (62%), Gaps = 5/97 (5%)
Query: 59 KERREEREKCLAAREQQILEKQKRARLQYEK--QMEERWRKLEEQRQREDQKRAAVEEK- 115
+++ +E+E+ + +E+++ E++++ Q EK + EE+ R+ EE+ Q +++K EEK
Sbjct: 624 EDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKM 683
Query: 116 --RKQKLREEEERLEAMMRRSLERTQQLELKKKYSWG 150
+++K+RE+EE++ + + +++ +++ WG
Sbjct: 684 QGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWG 720
Score = 47.0 bits (110), Expect = 6e-05
Identities = 27/96 (28%), Positives = 58/96 (60%), Gaps = 6/96 (6%)
Query: 59 KERREEREKCLAAREQQILEKQKRARLQYEK--QMEERWRKLEEQRQREDQKRAAVEEK- 115
+E E+EK + +E+++ +++R R Q K + EE+ R+ +E+R RE +K +EK
Sbjct: 240 EEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRR-QEKRLREQEKELREQEKE 298
Query: 116 --RKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
++KLRE+EE+++ + E+ +++ +++ W
Sbjct: 299 LREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMW 334
Score = 47.0 bits (110), Expect = 6e-05
Identities = 34/112 (30%), Positives = 61/112 (54%), Gaps = 7/112 (6%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQRE 105
E + DER R +ER E+EK E+ E++ R R + ++ EE R+ EE+ Q++
Sbjct: 359 ERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQ 418
Query: 106 DQKRAAVEEK--RKQKLREEEERL--EAMMRRSLERTQQLELK---KKYSWG 150
++ EEK ++Q+L E++E+L + M+ E+ + E K ++ WG
Sbjct: 419 EENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWG 470
Score = 46.6 bits (109), Expect = 8e-05
Identities = 26/120 (21%), Positives = 69/120 (57%), Gaps = 6/120 (5%)
Query: 26 KIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARL 85
K+ E + Q + E + +E+ +E+ +E+E+ + +E+++ E+++ ++
Sbjct: 568 KMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKM 627
Query: 86 QYEKQMEERWRKLEEQRQREDQKRAAVEEK---RKQKLREEEERLEAMMRRSLERTQQLE 142
Q +++M W + EE+ Q +++K EEK +++K+RE+EE+++ + E+ ++++
Sbjct: 628 QEQEEM--MWEQ-EEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQ 684
Score = 46.2 bits (108), Expect = 1e-04
Identities = 33/117 (28%), Positives = 67/117 (57%), Gaps = 9/117 (7%)
Query: 33 VRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEK--Q 90
+R + R Q E L+ E++ +++ E+E+ + +E+++ E++++ R Q EK +
Sbjct: 278 MRRQEKRLREQEKE--LREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWR 335
Query: 91 MEERWRKLEEQRQREDQKRAAVEEK---RKQKLREEEERL--EAMMRRSLERTQQLE 142
EER + E+Q + ++QK EE+ + ++LRE+EER+ + M E+ Q+ E
Sbjct: 336 QEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEE 392
Score = 46.2 bits (108), Expect = 1e-04
Identities = 30/106 (28%), Positives = 62/106 (58%), Gaps = 13/106 (12%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRAR-----LQYEKQMEERWRKLEEQRQR 104
+ +E+ R +++ ++E+ + +++++ EK++R R Q E++M E + E++++
Sbjct: 490 EQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKT 549
Query: 105 EDQKRAAVEEKR----KQKLREEEERLEAMMRRSLERTQQLELKKK 146
DQ+ EE+R ++K+REEEE MMR E+ Q+ E K +
Sbjct: 550 WDQEEKMREEERMREREKKMREEEE----MMREQEEKMQEQEEKMR 591
Score = 45.8 bits (107), Expect = 1e-04
Identities = 26/116 (22%), Positives = 64/116 (55%), Gaps = 3/116 (2%)
Query: 34 RTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEE 93
R + R + + + +E+ R K+ +E+ +K E+ E++ R R + ++ EE
Sbjct: 515 RLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEE 574
Query: 94 RWRKLEEQRQREDQKRAAVEEK---RKQKLREEEERLEAMMRRSLERTQQLELKKK 146
R+ EE+ Q +++K EEK +++K++E+EE++ + E+ ++ +++++
Sbjct: 575 MMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQ 630
Score = 40.4 bits (93), Expect = 0.006
Identities = 29/127 (22%), Positives = 65/127 (51%), Gaps = 6/127 (4%)
Query: 26 KIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARL 85
K+ E +R + R + E + +E+ + +E E+E+ +QQ L +QK
Sbjct: 387 KMQEEERIREREKKMREEE-ETMREQEEKMQKQEENMWEQEE--KEWQQQRLPEQKEKLW 443
Query: 86 QYEKQMEERWRKLEEQRQREDQKRAAVEEK---RKQKLREEEERLEAMMRRSLERTQQLE 142
+ EK E+ + E++ + DQ+ +EK R++K+RE+E+++ + ++ Q++
Sbjct: 444 EQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMW 503
Query: 143 LKKKYSW 149
+++ W
Sbjct: 504 DQEERMW 510
Score = 39.3 bits (90), Expect = 0.013
Identities = 29/100 (29%), Positives = 55/100 (55%), Gaps = 14/100 (14%)
Query: 53 ERQRLAKERREEREKCLAAREQQILEKQKRAR-----LQYEKQMEERWRKLEEQRQREDQ 107
E+ RLA+ + E + +++ K +RA+ +Q EE WR+ EE R++E +
Sbjct: 194 EKLRLAESEKSE----IQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKK 249
Query: 108 KRAAVEE--KRKQKLREEEERL---EAMMRRSLERTQQLE 142
R E+ +++++LRE+E ++ E MRR +R ++ E
Sbjct: 250 IRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQE 289
Score = 39.3 bits (90), Expect = 0.013
Identities = 26/103 (25%), Positives = 64/103 (62%), Gaps = 10/103 (9%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQK----RARLQYEKQMEERWRKL--EEQRQ 103
+ +++ R +ER E+++ L +E+++ E++K ++Q E+++ ER +K+ EE+
Sbjct: 349 EQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETM 408
Query: 104 REDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
RE +++ +K+++ + E+EE+ E +R E+ ++L ++K
Sbjct: 409 REQEEKM---QKQEENMWEQEEK-EWQQQRLPEQKEKLWEQEK 447
Score = 37.0 bits (84), Expect = 0.065
Identities = 24/100 (24%), Positives = 55/100 (55%), Gaps = 3/100 (3%)
Query: 49 LKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQK 108
L E+ + +E+ E+E+ + +E+ +++K R + ++ E++ + EE+ + ++QK
Sbjct: 442 LWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQK 501
Query: 109 RAAVEEK---RKQKLREEEERLEAMMRRSLERTQQLELKK 145
EE+ + ++LRE+EER+ + + + E KK
Sbjct: 502 MWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKK 541
Score = 36.6 bits (83), Expect = 0.085
Identities = 26/86 (30%), Positives = 51/86 (59%), Gaps = 11/86 (12%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEK---QMEERWRK------LEE 100
+ ++ Q ++ RE+ EK + +E+++ E++++ R Q EK Q E+ W + EE
Sbjct: 665 QEEKMQGQEEKMREQEEK-MQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEE 723
Query: 101 QRQREDQKRAAVEEKRKQKLREEEER 126
R++E++ R +EK +++L E EER
Sbjct: 724 MREKEERIRDQ-KEKMQERLPEHEER 748
Score = 33.9 bits (76), Expect = 0.55
Identities = 26/107 (24%), Positives = 56/107 (52%), Gaps = 17/107 (15%)
Query: 60 ERREEREKCLAAREQ-----QILEKQKRARLQYEKQMEER----WRKLEEQRQREDQKRA 110
+R+ ER K L + Q + + +Q+ + EK++ ++ WR+ E R++E + R
Sbjct: 214 KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE 273
Query: 111 AVEEKRKQ--KLREEEERLEAM------MRRSLERTQQLELKKKYSW 149
E+ R+Q +LRE+E+ L ++ E+ +Q++ +++ W
Sbjct: 274 QEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMW 320
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 81.6 bits (200), Expect = 2e-15
Identities = 119/553 (21%), Positives = 243/553 (43%), Gaps = 59/553 (10%)
Query: 60 ERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQK 119
E + +EK ++++ L + ++ +Q E + ++ KL +++ + ++A V+ K++ +
Sbjct: 1892 EEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLR 1951
Query: 120 ----LREEEERLEAMMRRSLERTQQL-ELKKKYSWGAPLAIGPGGHDACDKLSTSTMSLP 174
+ +EE+ L M+R E +L E K+ S G + TS
Sbjct: 1952 GELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKG-------------ETPETSRQRKM 1998
Query: 175 KPTEPPMNKRLSSSTVAISYSPDRVFHVCPRLAPLGPLNPSYKSSPTRNIEKKKATSTST 234
E + +R S I DR+ + G L + ++K A ++
Sbjct: 1999 TQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRK 2058
Query: 235 SGAGDVGKEALSGGEASL------VEKVKRGQRTATSLPVVNFGSPLRRCEFSGGIPKRP 288
+E+LS A L ++K+ R +R T + + ++R F + +R
Sbjct: 2059 LIKK---RESLSKEPAKLNKILKALQKLTRDERKLTQEEIKM--TKMKRALF---VKERR 2110
Query: 289 SSPVISKTATKAYPQSPKTTKPPYPGSPVKYRLPALSGQDMPKRKAEKEKSNKEREGTLA 348
S SK K + S K ++ + + L+ + +R KE+ E E LA
Sbjct: 2111 LSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANK--MRRMINKEEKMTEEESKLA 2168
Query: 349 ----------QQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAEN--SAALGKPTAGTTD 396
++ G + EE + + + ++ A G K + S+ + + +
Sbjct: 2169 RKHSEVILDDEEEGGIEEEEVIP--FLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHF 2226
Query: 397 AGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEE 456
+ E +L E +Q L E+EE ER E+EE++ E E + + +EE E++ K+EE
Sbjct: 2227 SEEMESLLDELEKQESLSSEEEE-EREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEE 2285
Query: 457 ERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAR 516
E+K++++EKKK+E +EK + EE + EE E+E++E +E++ + +
Sbjct: 2286 EKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREK---- 2341
Query: 517 EVAEQMRLEREQIMLQIEQERLERKKRIDEIMK---RTRKSDVPPQVKKEDPKVGVQPAV 573
E ++ E++ + + ++ L ++R+ I++ + + V K K + A+
Sbjct: 2342 ---EILKKEKQFKLQEQRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTAL 2398
Query: 574 CVEKKTKLVVPNK 586
+++KT + VP K
Sbjct: 2399 EMKEKTPVPVPEK 2411
Score = 64.7 bits (156), Expect = 3e-10
Identities = 58/218 (26%), Positives = 105/218 (48%), Gaps = 17/218 (7%)
Query: 331 KRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKP 390
+ A+ E ++E TLAQ+ G + + EK + K + E A G
Sbjct: 1628 REMAQAEGKFAQKEETLAQR--GEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGK 1685
Query: 391 TAGTTDAGEAAKILAEKRRQARLQKEQ----EEQERVEKEEQDRLEREELKRKAEEERLR 446
A E ILA+K + Q+EQ +E+E ++ E+ + EEL K EE
Sbjct: 1686 LA------EVKNILAQKVEELP-QREQNLDWQEKELAQELEELEWDMEELSWKEEE---- 1734
Query: 447 LEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEK 506
L +E K EE+K+ EE++ + ++ + EE K EEELL++EK++ + ++ M E+
Sbjct: 1735 LNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEE 1794
Query: 507 QKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRI 544
++ + + + ++M+L +++ E L + K I
Sbjct: 1795 EERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMI 1832
Score = 61.2 bits (147), Expect = 3e-09
Identities = 56/261 (21%), Positives = 124/261 (47%), Gaps = 25/261 (9%)
Query: 336 KEKSNKEREGTLAQQAAGPQGEEALEKHVVD--KHASEKHAAAAGGKAENSAALGKPTAG 393
KE+ K+ E ++ +GEE E+ V + +H E+H A + A +
Sbjct: 1534 KEQQYKDEEEVTLEEEVSREGEEK-EQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEE 1592
Query: 394 TTDAGEAAKILAEKRR---------QARLQKEQEEQERVEKEEQDRLEREELKRKAEEER 444
A E K+ E+R+ QA ++ Q+++E + E + + E L ++ E
Sbjct: 1593 RKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGE--- 1649
Query: 445 LRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMI 504
+L +EA K ++RK+ ++ +K EE++ A + K + +L ++ +E ++E+ +
Sbjct: 1650 -KLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLD 1708
Query: 505 EKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDV----PPQV 560
++KE A+ E++ + E++ + E+ E K ++E K + + ++
Sbjct: 1709 WQEKELAQE-----LEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKL 1763
Query: 561 KKEDPKVGVQPAVCVEKKTKL 581
+E+ K+ + + +++K KL
Sbjct: 1764 SEEETKLAQEEELLIQEKEKL 1784
Score = 58.2 bits (139), Expect = 3e-08
Identities = 54/217 (24%), Positives = 112/217 (51%), Gaps = 26/217 (11%)
Query: 401 AKILAEKRRQARLQKEQEEQER--VEKEEQDRLEREELKRKAEEERLRLEEEARKQEEE- 457
+++ ++++ AR Q++ + R + KEE+ E +L RK E L EEE +EEE
Sbjct: 2130 SELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEV 2189
Query: 458 ------RKRQEEEKKKQEGEEKRKAGEEAKRKAEE------ELLLKEKQEQE---KQEKA 502
R R+ +E K+ + +++ + + + ++EE E LL E ++QE +E+
Sbjct: 2190 IPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEE 2249
Query: 503 MIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKK 562
E+++E E + RE E+ + E E Q+E+E E+KK+ K+ +K + +V++
Sbjct: 2250 EREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKK-----KKEKKKE---EVQE 2301
Query: 563 EDPKVGVQPAVCVEKKTKLVVPNKMEINGLNTCQEVN 599
++ + + E++T+ + + E + +EV+
Sbjct: 2302 KEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVD 2338
Score = 54.7 bits (130), Expect = 3e-07
Identities = 110/557 (19%), Positives = 230/557 (41%), Gaps = 69/557 (12%)
Query: 25 GKIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERREE---------REKCLAAREQQ 75
GK+AE + + PQ + + + LA+E E +E+ L E +
Sbjct: 1684 GKLAEVKNILAQKVEELPQREQNL--DWQEKELAQELEELEWDMEELSWKEEELNQEEGK 1741
Query: 76 ILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEK-----RKQKLREEEERLEAM 130
++E++K+ + E +R + EE+ + ++ ++EK K+K+ EEEERL
Sbjct: 1742 LVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRK 1801
Query: 131 MRRSLERTQQLELKKKYSWGAPLAIGPGGHDACDKLSTSTMSL--------PKPTEPPMN 182
+ +E+ +L +K+ W ++ ++L+ + M L K
Sbjct: 1802 REQLIEKKMKL-AQKRERW----------INSMEELTKNKMILYQKKNLAQEKKNLAQEK 1850
Query: 183 KRLSSSTVAISYSPDRVFHVCPRLA----PLGPLNPSYKSSPTRNIEKKKATSTSTSGAG 238
++L+ + Y+ +R+ H +L LG N + ++K+
Sbjct: 1851 EKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKK----- 1905
Query: 239 DVGKEALSGGEASLVEKVKRGQRTATSLPVVNFGSPLRRCEFSGGIPKRPSSPVISKTAT 298
KE L+ E LV+ + L L + G KR +
Sbjct: 1906 ---KEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQG--KKRLRGELDIAKEE 1960
Query: 299 KAYPQSPKTTKPPYPGSPVKYRLPALSGQDMPKRKAEKEKSNKEREGTLAQQAAGPQGEE 358
KA K + ++ + G++ K E +++++R+ T +Q +
Sbjct: 1961 KALNLEMKRL--------AEEKMRLVEGKE-TLSKGETPETSRQRKMTQVEQELFERKLS 2011
Query: 359 ALEKHVV--DKHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKE 416
EK ++ D+ + + + A GK E + G +A++ L +KR L KE
Sbjct: 2012 LEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRES--LSKE 2069
Query: 417 QEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKA 476
+ ++ K Q +L R+E RK +E +++ + R + +R E+ K + +E +
Sbjct: 2070 PAKLNKILKALQ-KLTRDE--RKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFS 2126
Query: 477 GEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQE 536
+ ++ +E+ L +++++ + + MI K+++ E E ++ R E I+ E+
Sbjct: 2127 EKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTE----EESKLARKHSEVILDDEEEG 2182
Query: 537 RLERKKRIDEIMKRTRK 553
+E ++ I + +R RK
Sbjct: 2183 GIEEEEVIPFLKRRWRK 2199
Score = 51.2 bits (121), Expect = 3e-06
Identities = 54/238 (22%), Positives = 112/238 (47%), Gaps = 27/238 (11%)
Query: 326 GQDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAG-----GK 380
G+++ K++ +K ++G A Q G+ E ++ SE+ A K
Sbjct: 1384 GKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVK 1443
Query: 381 AENSAALGKPTAGTTDAGEA----AKILAEKRRQARLQKEQEEQERVEKEE--------- 427
E + + T D +A ++ E R+ + KE+ E+ +++EE
Sbjct: 1444 QEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKL 1503
Query: 428 --QDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAE 485
++ + +E+ K K EE + E + +E++ ++EE+ E EE + GEE +++
Sbjct: 1504 SPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLE-EEVSREGEEKEQQVT 1562
Query: 486 EELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKR 543
EE ++ QE+ + A I +++ AE K + E+ +L +E+ L E+ +L +++R
Sbjct: 1563 EE----QRHIQEEHKWARIHRKRARAEKKRAQ--EERKLAQEEEKLAQEERQLAQEER 1614
Score = 47.8 bits (112), Expect = 4e-05
Identities = 68/310 (21%), Positives = 128/310 (41%), Gaps = 68/310 (21%)
Query: 327 QDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGK------ 380
+++P+R+ + KE LAQ+ E LE + + E+ GK
Sbjct: 1698 EELPQREQNLDWQEKE----LAQEL------EELEWDMEELSWKEEELNQEEGKLVEEKK 1747
Query: 381 --AENSAALG----KPTAGTTDAGEAAKILAEKRRQARLQKEQ--EEQERVEKEEQDRLE 432
AE AL K + T + ++L +++ + KE+ EE+ER+ ++ + +E
Sbjct: 1748 KLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIE 1807
Query: 433 REELKRKAEEERLRLEEEARK------------QEEERKRQEEEK--------------- 465
++ + E + EE K QE++ QE+EK
Sbjct: 1808 KKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERL 1867
Query: 466 ---KKQEGEEKRKAGE--------EAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETK 514
KKQ + K K G E K E+E ++K+K++ + EK +++ + A+ +
Sbjct: 1868 THSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQ 1927
Query: 515 AREVAEQMRLEREQIMLQ------IEQERLERKKRIDEIMKRTRKSDVPPQVKKEDPKVG 568
+ E+M+L E+ M+Q E + + +K ++ MKR + + KE G
Sbjct: 1928 EKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKG 1987
Query: 569 VQPAVCVEKK 578
P ++K
Sbjct: 1988 ETPETSRQRK 1997
Score = 45.1 bits (105), Expect = 2e-04
Identities = 28/110 (25%), Positives = 58/110 (52%), Gaps = 11/110 (10%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQRE 105
E +E +R +E REE E + E++ E+++ Q EK+ EE+ +K +E+++ E
Sbjct: 2241 ESLSSEEEEEREEEEEREEEE--VREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEE 2298
Query: 106 DQKRAAVEEKRKQKLR---------EEEERLEAMMRRSLERTQQLELKKK 146
Q++ V E++++ + EEEE + ++R +++ K+K
Sbjct: 2299 VQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEK 2348
Score = 39.7 bits (91), Expect = 0.010
Identities = 37/155 (23%), Positives = 73/155 (47%), Gaps = 12/155 (7%)
Query: 403 ILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQE 462
+ E R + +EEQ + + + LE ++ K ++ + LE +E ++E
Sbjct: 1332 VTQEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKE 1391
Query: 463 EEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQM 522
E+K Q+ ++ + + +RK K K+E K+E+ M E+ +E A + + V ++
Sbjct: 1392 EKKTFQKSPKQGRKAVQKERKVG-----KIKREMTKEERDMSEEVEEMATLEEKVVKQEG 1446
Query: 523 RLEREQIMLQIEQERLERKKRIDE---IMKRTRKS 554
+L +M++ + KK DE + TRKS
Sbjct: 1447 KL----VMIERTPSWQDWKKAWDEWKQVHGETRKS 1477
Score = 38.5 bits (88), Expect = 0.022
Identities = 24/102 (23%), Positives = 56/102 (54%), Gaps = 5/102 (4%)
Query: 50 KSDERQRLAKE---RREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQRED 106
K +E L +E EE+E+ + ++ I E+ K AR+ ++ E+ R EE++ ++
Sbjct: 1539 KDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQE 1598
Query: 107 QKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYS 148
+++ A EE +Q +EE + +A ++ + + + + + K++
Sbjct: 1599 EEKLAQEE--RQLAQEERKLAQAYVKITQDDREMAQAEGKFA 1638
Score = 38.1 bits (87), Expect = 0.029
Identities = 29/136 (21%), Positives = 68/136 (50%), Gaps = 4/136 (2%)
Query: 53 ERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAV 112
E +++ KE E+++K +++++ EK++ + E EE L ++ + E+
Sbjct: 2276 EEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEE 2335
Query: 113 EEKRKQKL--REEEERLEAMMRRSLE-RTQQLELKKKYSWGAPLAIGPGG-HDACDKLST 168
E R++++ +E++ +L+ R+SL R + L + + G AI G KL +
Sbjct: 2336 EVDREKEILKKEKQFKLQEQRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSPLKKLMS 2395
Query: 169 STMSLPKPTEPPMNKR 184
+ + + + T P+ ++
Sbjct: 2396 TALEMKEKTPVPVPEK 2411
Score = 37.4 bits (85), Expect = 0.050
Identities = 43/200 (21%), Positives = 94/200 (47%), Gaps = 16/200 (8%)
Query: 404 LAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEE 463
LA+K+ + +K + E+ + + RL R EL EE+ L LE + R EE+ + E
Sbjct: 1923 LAKKQEKLAQEKMKLALEKAMVQGKKRL-RGELDIAKEEKALNLEMK-RLAEEKMRLVEG 1980
Query: 464 EKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEK----QEKAMIEKQKEAAETKAREVA 519
++ +GE + + + E+EL ++ +EK +++ + ++ E A+ K
Sbjct: 1981 KETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTR 2040
Query: 520 EQMRLEREQIMLQIEQERLERKK--------RIDEIMKRTRK--SDVPPQVKKEDPKVGV 569
Q + Q L +L +K+ ++++I+K +K D ++E +
Sbjct: 2041 GQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKM 2100
Query: 570 QPAVCVEKKTKLVVPNKMEI 589
+ A+ V+++ + +K++I
Sbjct: 2101 KRALFVKERRLSIEQSKLDI 2120
Score = 34.3 bits (77), Expect = 0.42
Identities = 23/96 (23%), Positives = 51/96 (53%), Gaps = 4/96 (4%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKL---EEQRQRED 106
+ D A+ + ++E+ LA R +++ ++ ++ Q K++ ++W K+ EE+ ++
Sbjct: 1625 QDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLA-QKRKKLAKKWEKVAREEEKLAKKG 1683
Query: 107 QKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLE 142
K A V+ QK+ E +R + + + E Q+LE
Sbjct: 1684 GKLAEVKNILAQKVEELPQREQNLDWQEKELAQELE 1719
Score = 33.9 bits (76), Expect = 0.55
Identities = 19/77 (24%), Positives = 41/77 (53%)
Query: 49 LKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQK 108
L +ERQ +ER+ + ++ + + + + Q E+ + +R KL ++ ++ QK
Sbjct: 1602 LAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQK 1661
Query: 109 RAAVEEKRKQKLREEEE 125
R + +K ++ REEE+
Sbjct: 1662 RKKLAKKWEKVAREEEK 1678
Score = 33.5 bits (75), Expect = 0.72
Identities = 23/105 (21%), Positives = 53/105 (50%), Gaps = 6/105 (5%)
Query: 48 FLKSDERQRLAKERREEREKCLAAR------EQQILEKQKRARLQYEKQMEERWRKLEEQ 101
FLK R+R +R ++ ++ +++ E+ E+ + + EKQ + EE+
Sbjct: 2192 FLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEER 2251
Query: 102 RQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
+ E+++ V E+ +++ EEE + + + E+ ++ + KKK
Sbjct: 2252 EEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKK 2296
Score = 32.7 bits (73), Expect = 1.2
Identities = 38/143 (26%), Positives = 64/143 (44%), Gaps = 23/143 (16%)
Query: 29 EPGAVRTSQPNYRPQGMEGFLKSDERQRLA--KERR----------EEREKCLAAREQQI 76
EPG V + + + + F KS ++ R A KER+ EER+ E
Sbjct: 1377 EPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMAT 1436
Query: 77 LEKQKRARLQYEKQMEER------WRKL-EEQRQREDQKRA---AVEEKRKQKLREEEER 126
LE +K + + + M ER W+K +E +Q + R A +E+ +++L +EEE+
Sbjct: 1437 LE-EKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEK 1495
Query: 127 LEAMMRRSLERTQQLELKKKYSW 149
L + + L+ KK W
Sbjct: 1496 LHQAGEKLSPEEEMLQEDKKLKW 1518
Score = 32.7 bits (73), Expect = 1.2
Identities = 23/98 (23%), Positives = 52/98 (53%), Gaps = 11/98 (11%)
Query: 43 QGMEGFLKSDERQRLAKERREEREKCLAARE-----QQILEKQKRARLQYEKQMEERWRK 97
+G E ++ +E ++ K++ +++E+ E ++I+ +++ L E++ EE
Sbjct: 2274 EGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESC-S 2332
Query: 98 LEEQRQRE-----DQKRAAVEEKRKQKLREEEERLEAM 130
LEE+ RE +K+ ++E+R++ LR E L +
Sbjct: 2333 LEEEVDREKEILKKEKQFKLQEQRRKSLRGRERVLSIL 2370
Score = 31.2 bits (69), Expect = 3.6
Identities = 22/117 (18%), Positives = 57/117 (48%), Gaps = 9/117 (7%)
Query: 31 GAVRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQ 90
G R S ++ + + L+ +E+ A E+ + E+++L++ K+ + + KQ
Sbjct: 1472 GETRKSWKAWKEEWEKRLLQEEEKLHQAGEK--------LSPEEEMLQEDKKLKWEEWKQ 1523
Query: 91 M-EERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
+ E +++Q +D++ +EE+ ++ E+E+++ R E + + +K
Sbjct: 1524 VWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRK 1580
Score = 30.0 bits (66), Expect = 8.0
Identities = 26/108 (24%), Positives = 54/108 (50%), Gaps = 13/108 (12%)
Query: 52 DERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKL-EEQRQ--REDQK 108
++ Q++ +E+R +E+ AR + + ++ R Q E+++ + KL +E+RQ +E++K
Sbjct: 1556 EKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERK 1615
Query: 109 RAAVEEKRKQ----------KLREEEERLEAMMRRSLERTQQLELKKK 146
A K Q K ++EE L + + ++L K+K
Sbjct: 1616 LAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRK 1663
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 81.3 bits (199), Expect = 3e-15
Identities = 50/164 (30%), Positives = 93/164 (56%), Gaps = 7/164 (4%)
Query: 382 ENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDR---LEREELKR 438
E S+ L P T LA K R L+++Q EQ++ E EE R ER++
Sbjct: 337 EPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIE 396
Query: 439 KAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEK 498
+ +E+R RLEE+ R+++E RK+QE E+++ E+ R+ E + + E+E + ++ +E+++
Sbjct: 397 EQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQR 456
Query: 499 Q----EKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERL 538
Q ++ ++ +Q E K +++ EQ + ER Q L+ E++ L
Sbjct: 457 QLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYL 500
Score = 71.2 bits (173), Expect = 3e-12
Identities = 52/170 (30%), Positives = 98/170 (57%), Gaps = 20/170 (11%)
Query: 396 DAGEAAKIL------AEKRRQARLQ---KEQEEQERVEKEEQDRLEREELKRKAEEERL- 445
D+GE + IL +R RLQ KE+ E R ++ EQ + E EE KR+ ER
Sbjct: 334 DSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQK 393
Query: 446 RLEE--EARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAM 503
R+EE E R++ EE++R+E+E +KQ+ E+R+ EE R+ EE + + EQE + +
Sbjct: 394 RIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEER--RRAEHEQEYIRRQL 451
Query: 504 IEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRK 553
E+Q++ E+ +Q L + ++L+ ++++LE +++ + + ++ ++
Sbjct: 452 EEEQRQL------EILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQ 495
Score = 59.7 bits (143), Expect = 9e-09
Identities = 57/247 (23%), Positives = 113/247 (45%), Gaps = 20/247 (8%)
Query: 331 KRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKH--AAAAGGKAENSAALG 388
K++ EK+++ E G+ ++ GE + ++ + + K + A
Sbjct: 311 KKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRR 370
Query: 389 KPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLE 448
+ E K RQ R++ EQ+EQ R EEQ R E+E K++ E+R E
Sbjct: 371 QQLEQQQRENEEHKRQLLAERQKRIE-EQKEQRR-RLEEQQRREKELRKQQEREQRRHYE 428
Query: 449 EEARKQEEERKRQEEEK--KKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEK 506
E+ R++EE R+ + E++ ++Q EE+R+ ++ E+ LL E + ++ +E
Sbjct: 429 EQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEE------ 482
Query: 507 QKEAAETKAREVAEQMRLEREQIML---QIEQERLERKKRIDEIMKRTRKSDVPPQVKKE 563
+ +A + Q++ ER+ ++ Q +++R KK + + S+ P K+
Sbjct: 483 -----QRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEI 537
Query: 564 DPKVGVQ 570
V V+
Sbjct: 538 PHLVAVK 544
Score = 51.6 bits (122), Expect = 3e-06
Identities = 38/109 (34%), Positives = 65/109 (59%), Gaps = 16/109 (14%)
Query: 54 RQRLAKERREERE---KCLAAREQQI---------LEKQKRARLQYEKQME-ERWRKLEE 100
RQ+L +++RE E + LA R+++I LE+Q+R + KQ E E+ R EE
Sbjct: 370 RQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEE 429
Query: 101 QRQREDQKRAAVEEKR--KQKLREEEERLEAMMRRSL-ERTQQLELKKK 146
Q +RE+++R A E+ +++L EE+ +LE + ++ L E+ LE K+K
Sbjct: 430 QMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRK 478
Score = 47.4 bits (111), Expect = 5e-05
Identities = 35/98 (35%), Positives = 60/98 (61%), Gaps = 11/98 (11%)
Query: 54 RQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQM-EERWRKLE---EQRQREDQKR 109
R +LA + R E A R QQ LE+Q+R ++++Q+ ER +++E EQR+R ++++
Sbjct: 356 RLQLANKERSE-----ALRRQQ-LEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQ 409
Query: 110 AAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKY 147
+E RKQ+ RE+ E MRR ER ++ E +++Y
Sbjct: 410 RREKELRKQQEREQRRHYEEQMRREEER-RRAEHEQEY 446
Score = 45.8 bits (107), Expect = 1e-04
Identities = 37/154 (24%), Positives = 75/154 (48%), Gaps = 8/154 (5%)
Query: 415 KEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKR 474
++Q + +V + +D ++R + KR ++E E E EEE +EE +
Sbjct: 290 RDQPNERQVRIQLKDHIDRTKKKRGEKDET---EYEYSGSEEE---EEENDSGEPSSILN 343
Query: 475 KAGEEAKRKAEEELLLKEKQEQEKQEKAMIE-KQKEAAETKAREVAE-QMRLEREQIMLQ 532
GE R+ L L K+ E + +E +Q+E E K + +AE Q R+E ++ +
Sbjct: 344 LPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRR 403
Query: 533 IEQERLERKKRIDEIMKRTRKSDVPPQVKKEDPK 566
+E+ R+K + + +R ++ Q+++E+ +
Sbjct: 404 RLEEQQRREKELRKQQEREQRRHYEEQMRREEER 437
Score = 44.3 bits (103), Expect = 4e-04
Identities = 85/427 (19%), Positives = 159/427 (37%), Gaps = 60/427 (14%)
Query: 52 DERQRLAKERREEREKCLAAR-EQQILEKQKRARLQYE-----KQMEERWRKLEEQRQRE 105
+E+QR KE R+++E+ E+Q+ +++R R ++E +Q+EE R+LE +Q+
Sbjct: 406 EEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQL 465
Query: 106 DQKRAAVEEKRKQKLREEE--ERLEAMMRRSLERTQQLELKKKYSWGAPLAIGPGGHDAC 163
++A + E ++++L E+ ERL+ +++ ER + L+ + P+ P H
Sbjct: 466 LHEQALLLEYKRKQLEEQRQAERLQRQLKQ--ERDYLVSLQHQRQEQRPVEKKPLYH--- 520
Query: 164 DKLSTSTMSLPKPTEPPMNKRLSSSTVAISYSPDRVFHVCPRLAPLGPLNPSYKSSPTRN 223
MS P+E P + VA+ P + S PT+
Sbjct: 521 ---YKEGMS---PSEKPAWAKEIPHLVAVKSQ-----------GPALTASQSVHEQPTKG 563
Query: 224 IEKKKATSTSTSGAGDVGKEALSGGEASLVEKVKRGQRTATSLPVVNFGSPLRRCEFSGG 283
+ + TS ++ ++ T+ + P+ P R +F
Sbjct: 564 LSGFQEALNVTSHRVEMPRQ--------------NSDPTSENPPL-----PTRIEKFDRS 604
Query: 284 IPKRPSSPVISKTATKAYPQSPKTTKPPYPGSPVKYRLPALSGQDMPKRKAEKEKSNKER 343
R + K + SP + PG+ P L Q + + ++
Sbjct: 605 SWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALG-PRLGSQPIRASNPDLRRTEPIL 663
Query: 344 EGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAE-----NSAALGKPTAGTTDAG 398
E L + ++G + + + AG NS + G P
Sbjct: 664 ESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVL----PH 719
Query: 399 EAAKILAEKRRQARLQKEQEEQERVEKEEQD-RLEREELKRKAEEERLRLEEEARKQEEE 457
E AK+ E+ R + + KE ++ R+E K + EE+ EEE
Sbjct: 720 EPAKVKPEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEE 779
Query: 458 RKRQEEE 464
+ E E
Sbjct: 780 EEDGESE 786
Score = 34.7 bits (78), Expect = 0.32
Identities = 21/78 (26%), Positives = 43/78 (55%), Gaps = 12/78 (15%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQ------KRARLQYEKQMEERWRKLEEQR- 102
+++ Q + + EE ++ L +QQ+L +Q KR +L+ ++Q E R+L+++R
Sbjct: 439 RAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERD 498
Query: 103 -----QREDQKRAAVEEK 115
Q + Q++ VE+K
Sbjct: 499 YLVSLQHQRQEQRPVEKK 516
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 81.3 bits (199), Expect = 3e-15
Identities = 50/164 (30%), Positives = 93/164 (56%), Gaps = 7/164 (4%)
Query: 382 ENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDR---LEREELKR 438
E S+ L P T LA K R L+++Q EQ++ E EE R ER++
Sbjct: 337 EPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIE 396
Query: 439 KAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEK 498
+ +E+R RLEE+ R+++E RK+QE E+++ E+ R+ E + + E+E + ++ +E+++
Sbjct: 397 EQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQR 456
Query: 499 Q----EKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERL 538
Q ++ ++ +Q E K +++ EQ + ER Q L+ E++ L
Sbjct: 457 QLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYL 500
Score = 71.2 bits (173), Expect = 3e-12
Identities = 52/170 (30%), Positives = 98/170 (57%), Gaps = 20/170 (11%)
Query: 396 DAGEAAKIL------AEKRRQARLQ---KEQEEQERVEKEEQDRLEREELKRKAEEERL- 445
D+GE + IL +R RLQ KE+ E R ++ EQ + E EE KR+ ER
Sbjct: 334 DSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQK 393
Query: 446 RLEE--EARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAM 503
R+EE E R++ EE++R+E+E +KQ+ E+R+ EE R+ EE + + EQE + +
Sbjct: 394 RIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEER--RRAEHEQEYIRRQL 451
Query: 504 IEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRK 553
E+Q++ E+ +Q L + ++L+ ++++LE +++ + + ++ ++
Sbjct: 452 EEEQRQL------EILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQ 495
Score = 59.7 bits (143), Expect = 9e-09
Identities = 57/247 (23%), Positives = 113/247 (45%), Gaps = 20/247 (8%)
Query: 331 KRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKH--AAAAGGKAENSAALG 388
K++ EK+++ E G+ ++ GE + ++ + + K + A
Sbjct: 311 KKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRR 370
Query: 389 KPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLE 448
+ E K RQ R++ EQ+EQ R EEQ R E+E K++ E+R E
Sbjct: 371 QQLEQQQRENEEHKRQLLAERQKRIE-EQKEQRR-RLEEQQRREKELRKQQEREQRRHYE 428
Query: 449 EEARKQEEERKRQEEEK--KKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEK 506
E+ R++EE R+ + E++ ++Q EE+R+ ++ E+ LL E + ++ +E
Sbjct: 429 EQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEE------ 482
Query: 507 QKEAAETKAREVAEQMRLEREQIML---QIEQERLERKKRIDEIMKRTRKSDVPPQVKKE 563
+ +A + Q++ ER+ ++ Q +++R KK + + S+ P K+
Sbjct: 483 -----QRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEI 537
Query: 564 DPKVGVQ 570
V V+
Sbjct: 538 PHLVAVK 544
Score = 53.9 bits (128), Expect = 5e-07
Identities = 91/450 (20%), Positives = 176/450 (39%), Gaps = 41/450 (9%)
Query: 54 RQRLAKERREERE---KCLAAREQQI---------LEKQKRARLQYEKQME-ERWRKLEE 100
RQ+L +++RE E + LA R+++I LE+Q+R + KQ E E+ R EE
Sbjct: 370 RQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEE 429
Query: 101 QRQREDQKRAAVEEKR--KQKLREEEERLEAMMRRSL-ERTQQLELKKKYSWGAPLAIGP 157
Q +RE+++R A E+ +++L EE+ +LE + ++ L E+ LE K+K A
Sbjct: 430 QMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERL 489
Query: 158 GGHDACDKLSTSTMSLPKPTEPPMNKR-LSSSTVAISYSPDRVF-HVCPRLAPLGPLNPS 215
++ ++ + + P+ K+ L +S S + P L + P+
Sbjct: 490 QRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPA 549
Query: 216 YKSSPTRNIEKKKATSTSTSGAGDVGKEALSGGEASLVEKVKRGQRTATSLPVVNFGSPL 275
+S + + + K S +EAL+ + + T+ + P+ P
Sbjct: 550 LTASQSVHEQPTKGLSGF--------QEALNVTSHRVEMPRQNSDPTSENPPL-----PT 596
Query: 276 RRCEFSGGIPKRPSSPVISKTATKAYPQSPKTTKPPYPGSPVKYRLPALSGQDMPKRKAE 335
R +F R + K + SP + PG+ P L Q + +
Sbjct: 597 RIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALG-PRLGSQPIRASNPD 655
Query: 336 KEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAE-----NSAALGKP 390
++ E L + ++G + + + AG NS + G P
Sbjct: 656 LRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSP 715
Query: 391 TAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEE 450
E AK+ E+ R ++ E+ L +E + + EE +++
Sbjct: 716 VL----PHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKV 771
Query: 451 ARKQEEERKRQEEEKKKQEGEEKRKAGEEA 480
+ + E+++++GE + G A
Sbjct: 772 TDYSSSSEESESSEEEEEDGESETHDGTVA 801
Score = 47.4 bits (111), Expect = 5e-05
Identities = 35/98 (35%), Positives = 60/98 (61%), Gaps = 11/98 (11%)
Query: 54 RQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQM-EERWRKLE---EQRQREDQKR 109
R +LA + R E A R QQ LE+Q+R ++++Q+ ER +++E EQR+R ++++
Sbjct: 356 RLQLANKERSE-----ALRRQQ-LEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQ 409
Query: 110 AAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKY 147
+E RKQ+ RE+ E MRR ER ++ E +++Y
Sbjct: 410 RREKELRKQQEREQRRHYEEQMRREEER-RRAEHEQEY 446
Score = 45.8 bits (107), Expect = 1e-04
Identities = 37/154 (24%), Positives = 75/154 (48%), Gaps = 8/154 (5%)
Query: 415 KEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKR 474
++Q + +V + +D ++R + KR ++E E E EEE +EE +
Sbjct: 290 RDQPNERQVRIQLKDHIDRTKKKRGEKDET---EYEYSGSEEE---EEENDSGEPSSILN 343
Query: 475 KAGEEAKRKAEEELLLKEKQEQEKQEKAMIE-KQKEAAETKAREVAE-QMRLEREQIMLQ 532
GE R+ L L K+ E + +E +Q+E E K + +AE Q R+E ++ +
Sbjct: 344 LPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRR 403
Query: 533 IEQERLERKKRIDEIMKRTRKSDVPPQVKKEDPK 566
+E+ R+K + + +R ++ Q+++E+ +
Sbjct: 404 RLEEQQRREKELRKQQEREQRRHYEEQMRREEER 437
Score = 39.3 bits (90), Expect = 0.013
Identities = 75/394 (19%), Positives = 149/394 (37%), Gaps = 71/394 (18%)
Query: 52 DERQRLAKERREEREKCLAAR-EQQILEKQKRARLQYE-----KQMEERWRKLEEQRQRE 105
+E+QR KE R+++E+ E+Q+ +++R R ++E +Q+EE R+LE +Q+
Sbjct: 406 EEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQL 465
Query: 106 DQKRAAVEEKRKQKLREEE--ERLEAMMRRSLE--------RTQQLELKKKYSWGAPLAI 155
++A + E ++++L E+ ERL+ +++ + R +Q ++KK + +
Sbjct: 466 LHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGM 525
Query: 156 GPGG---------HDACDKLSTSTMSLPKPTEPPMNKRLSSSTVAISYSPDRVFHVCPRL 206
P H K ++ + K LS A++ + RV
Sbjct: 526 SPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNS 585
Query: 207 AP-------------------------LGPLNPSYKSSPTRNIEKKKATSTSTSGAGDVG 241
P + P P +S + + +K + ++ +G
Sbjct: 586 DPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLG 645
Query: 242 KEALSGGEASL----------VEKVKRGQRTATSLPVVNFGSPLRRCEFSGGIPKRPSSP 291
+ + L +++ G +++S P S GG +P S
Sbjct: 646 SQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSS-------QGG--SQPGSQ 696
Query: 292 VISKTATKAYPQSPKTTKPPYPGSPVKYRLPALSGQDMPKRKAEKEKSNKEREGTLAQQA 351
S T+ S P P P K + P R A +K+ E LA++
Sbjct: 697 AGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAKEL 756
Query: 352 AGPQGEEALE--KHVVDKHASEKHAAAAGGKAEN 383
+ EE K V D +S + + ++ + E+
Sbjct: 757 RELRIEETNRPMKKVTDYSSSSEESESSEEEEED 790
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 81.3 bits (199), Expect = 3e-15
Identities = 50/164 (30%), Positives = 93/164 (56%), Gaps = 7/164 (4%)
Query: 382 ENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDR---LEREELKR 438
E S+ L P T LA K R L+++Q EQ++ E EE R ER++
Sbjct: 337 EPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIE 396
Query: 439 KAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEK 498
+ +E+R RLEE+ R+++E RK+QE E+++ E+ R+ E + + E+E + ++ +E+++
Sbjct: 397 EQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQR 456
Query: 499 Q----EKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERL 538
Q ++ ++ +Q E K +++ EQ + ER Q L+ E++ L
Sbjct: 457 QLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYL 500
Score = 71.2 bits (173), Expect = 3e-12
Identities = 52/170 (30%), Positives = 98/170 (57%), Gaps = 20/170 (11%)
Query: 396 DAGEAAKIL------AEKRRQARLQ---KEQEEQERVEKEEQDRLEREELKRKAEEERL- 445
D+GE + IL +R RLQ KE+ E R ++ EQ + E EE KR+ ER
Sbjct: 334 DSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQK 393
Query: 446 RLEE--EARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAM 503
R+EE E R++ EE++R+E+E +KQ+ E+R+ EE R+ EE + + EQE + +
Sbjct: 394 RIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEER--RRAEHEQEYIRRQL 451
Query: 504 IEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRK 553
E+Q++ E+ +Q L + ++L+ ++++LE +++ + + ++ ++
Sbjct: 452 EEEQRQL------EILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQ 495
Score = 59.3 bits (142), Expect = 1e-08
Identities = 59/249 (23%), Positives = 108/249 (43%), Gaps = 31/249 (12%)
Query: 343 REGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAAK 402
R L Q A + EAL + +++ E AE + + + +
Sbjct: 351 RRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKE------QRRR 404
Query: 403 ILAEKRRQARLQKEQEEQERVEKEEQDRLEREE---------LKRKAEEERLRLEEEARK 453
+ ++RR+ L+K+QE ++R EEQ R E E ++R+ EEE+ +LE ++
Sbjct: 405 LEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQ 464
Query: 454 QEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLK---EKQEQEKQEKAMIEKQKEA 510
E+ E K+KQ E+++ + + K E + L+ ++QEQ EK + KE
Sbjct: 465 LLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEG 524
Query: 511 AETK-----AREVAEQMRLERE-------QIMLQIEQERLERKKRIDEIMKRTRKSDVPP 558
A+EV E+ RL R+ ++ +I L + I + + PP
Sbjct: 525 MSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSI-SGVQPARTPP 583
Query: 559 QVKKEDPKV 567
++ DP++
Sbjct: 584 MLRPVDPQI 592
Score = 57.0 bits (136), Expect = 6e-08
Identities = 90/450 (20%), Positives = 173/450 (38%), Gaps = 51/450 (11%)
Query: 52 DERQRLAKERREEREKCLAAR-EQQILEKQKRARLQYE-----KQMEERWRKLEEQRQRE 105
+E+QR KE R+++E+ E+Q+ +++R R ++E +Q+EE R+LE +Q+
Sbjct: 406 EEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQL 465
Query: 106 DQKRAAVEEKRKQKLREEE--ERLEAMMRRSL--------ERTQQLELKKKYSWGAPLAI 155
++A + E ++++L E+ ERL+ +++ +R +Q ++KK + +
Sbjct: 466 LHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGM 525
Query: 156 GPGGHDACDKLSTSTMSLPKPTEPPM---------NKRLSSSTVAISYSPDRVFHVCPRL 206
P A K L + + P M + L + + S S + P L
Sbjct: 526 SPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPML 585
Query: 207 APLGPLNPSYKSSPTRNIEKKKATSTSTSGAGDVGKEALSGGEASL------VEKVKRGQ 260
P+ P P + ++ + T++ + + LSG + +L VE ++
Sbjct: 586 RPVDPQIPHLVA-----VKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNS 640
Query: 261 RTATSLPVVNFGSPLRRCEFSGGIPKRPSSPVISKTATKAYPQSPKTTKPPYPGSPVKYR 320
+ P + P R +F R + K + SP + PG+
Sbjct: 641 DPTSENPPL----PTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALG 696
Query: 321 LPALSGQDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGK 380
P L Q + + ++ E L + ++G + + + AG
Sbjct: 697 -PRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSS 755
Query: 381 AE-----NSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQD-RLERE 434
NS + G P E AK+ E+ R + + KE ++ R+E
Sbjct: 756 ERTRVRANSKSEGSPVL----PHEPAKVKPEESRDITRPSRPADLTALAKELRELRIEET 811
Query: 435 ELKRKAEEERLRLEEEARKQEEERKRQEEE 464
K + EE+ EEE + E E
Sbjct: 812 NRPMKKVTDYSSSSEESESSEEEEEDGESE 841
Score = 55.1 bits (131), Expect = 2e-07
Identities = 47/171 (27%), Positives = 86/171 (50%), Gaps = 32/171 (18%)
Query: 409 RQARLQ-KEQEEQERVEKEEQDRLEREELKRKAEEER----------------------L 445
RQ R+Q K+ ++ + ++ E+D E E + EEE L
Sbjct: 296 RQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFL 355
Query: 446 RLEEEARKQEEERKRQEEEKKKQEGEEKRK--AGEEAKRKAEEELLLKEKQEQEKQEKAM 503
RL+ +++ E +RQ+ E++++E EE ++ E KR E++ + +EQ+++EK
Sbjct: 356 RLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK-- 413
Query: 504 IEKQKEAAETKAREVAEQMRLEREQIMLQIEQE----RLERKKRIDEIMKR 550
E +K+ + R EQMR E E+ + EQE +LE ++R EI+++
Sbjct: 414 -ELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQ 463
Score = 47.4 bits (111), Expect = 5e-05
Identities = 35/98 (35%), Positives = 60/98 (61%), Gaps = 11/98 (11%)
Query: 54 RQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQM-EERWRKLE---EQRQREDQKR 109
R +LA + R E A R QQ LE+Q+R ++++Q+ ER +++E EQR+R ++++
Sbjct: 356 RLQLANKERSE-----ALRRQQ-LEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQ 409
Query: 110 AAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKY 147
+E RKQ+ RE+ E MRR ER ++ E +++Y
Sbjct: 410 RREKELRKQQEREQRRHYEEQMRREEER-RRAEHEQEY 446
Score = 45.8 bits (107), Expect = 1e-04
Identities = 37/154 (24%), Positives = 75/154 (48%), Gaps = 8/154 (5%)
Query: 415 KEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKR 474
++Q + +V + +D ++R + KR ++E E E EEE +EE +
Sbjct: 290 RDQPNERQVRIQLKDHIDRTKKKRGEKDET---EYEYSGSEEE---EEENDSGEPSSILN 343
Query: 475 KAGEEAKRKAEEELLLKEKQEQEKQEKAMIE-KQKEAAETKAREVAE-QMRLEREQIMLQ 532
GE R+ L L K+ E + +E +Q+E E K + +AE Q R+E ++ +
Sbjct: 344 LPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRR 403
Query: 533 IEQERLERKKRIDEIMKRTRKSDVPPQVKKEDPK 566
+E+ R+K + + +R ++ Q+++E+ +
Sbjct: 404 RLEEQQRREKELRKQQEREQRRHYEEQMRREEER 437
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 81.3 bits (199), Expect = 3e-15
Identities = 50/164 (30%), Positives = 93/164 (56%), Gaps = 7/164 (4%)
Query: 382 ENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDR---LEREELKR 438
E S+ L P T LA K R L+++Q EQ++ E EE R ER++
Sbjct: 337 EPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIE 396
Query: 439 KAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEK 498
+ +E+R RLEE+ R+++E RK+QE E+++ E+ R+ E + + E+E + ++ +E+++
Sbjct: 397 EQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQR 456
Query: 499 Q----EKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERL 538
Q ++ ++ +Q E K +++ EQ + ER Q L+ E++ L
Sbjct: 457 QLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYL 500
Score = 71.2 bits (173), Expect = 3e-12
Identities = 52/170 (30%), Positives = 98/170 (57%), Gaps = 20/170 (11%)
Query: 396 DAGEAAKIL------AEKRRQARLQ---KEQEEQERVEKEEQDRLEREELKRKAEEERL- 445
D+GE + IL +R RLQ KE+ E R ++ EQ + E EE KR+ ER
Sbjct: 334 DSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQK 393
Query: 446 RLEE--EARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAM 503
R+EE E R++ EE++R+E+E +KQ+ E+R+ EE R+ EE + + EQE + +
Sbjct: 394 RIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEER--RRAEHEQEYIRRQL 451
Query: 504 IEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRK 553
E+Q++ E+ +Q L + ++L+ ++++LE +++ + + ++ ++
Sbjct: 452 EEEQRQL------EILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQ 495
Score = 59.3 bits (142), Expect = 1e-08
Identities = 59/249 (23%), Positives = 108/249 (43%), Gaps = 31/249 (12%)
Query: 343 REGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAAK 402
R L Q A + EAL + +++ E AE + + + +
Sbjct: 351 RRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKE------QRRR 404
Query: 403 ILAEKRRQARLQKEQEEQERVEKEEQDRLEREE---------LKRKAEEERLRLEEEARK 453
+ ++RR+ L+K+QE ++R EEQ R E E ++R+ EEE+ +LE ++
Sbjct: 405 LEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQ 464
Query: 454 QEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLK---EKQEQEKQEKAMIEKQKEA 510
E+ E K+KQ E+++ + + K E + L+ ++QEQ EK + KE
Sbjct: 465 LLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEG 524
Query: 511 AETK-----AREVAEQMRLERE-------QIMLQIEQERLERKKRIDEIMKRTRKSDVPP 558
A+EV E+ RL R+ ++ +I L + I + + PP
Sbjct: 525 MSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSI-SGVQPARTPP 583
Query: 559 QVKKEDPKV 567
++ DP++
Sbjct: 584 MLRPVDPQI 592
Score = 59.3 bits (142), Expect = 1e-08
Identities = 88/465 (18%), Positives = 180/465 (38%), Gaps = 50/465 (10%)
Query: 52 DERQRLAKERREEREKCLAAR-EQQILEKQKRARLQYE-----KQMEERWRKLEEQRQRE 105
+E+QR KE R+++E+ E+Q+ +++R R ++E +Q+EE R+LE +Q+
Sbjct: 406 EEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQL 465
Query: 106 DQKRAAVEEKRKQKLREEE--ERLEAMMRRSL--------ERTQQLELKKKYSWGAPLAI 155
++A + E ++++L E+ ERL+ +++ +R +Q ++KK + +
Sbjct: 466 LHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGM 525
Query: 156 GPGGHDACDKLSTSTMSLPKPTEPPM---------NKRLSSSTVAISYSPDRVFHVCPRL 206
P A K L + + P M + L + + S S + P L
Sbjct: 526 SPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPML 585
Query: 207 APLGPLNPSYKSSPTRNIEKKKATSTSTSGAGDVGKEALSGGEASL------VEKVKRGQ 260
P+ P P + ++ + T++ + + LSG + +L VE ++
Sbjct: 586 RPVDPQIPHLVA-----VKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNS 640
Query: 261 RTATSLPVVNFGSPLRRCEFSGGIPKRPSSPVISKTATKAYPQSPKTTKPPYPGSPVKYR 320
+ P + P R +F R + K + SP + PG+
Sbjct: 641 DPTSENPPL----PTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALG 696
Query: 321 LPALSGQDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGK 380
P L Q + + ++ E L + ++G + + + AG
Sbjct: 697 -PRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSS 755
Query: 381 AE-----NSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREE 435
NS + G P E AK+ E+ R ++ E+ L +E
Sbjct: 756 ERTRVRANSKSEGSPVL----PHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAKEL 811
Query: 436 LKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEA 480
+ + EE +++ + + E+++++GE + G A
Sbjct: 812 RELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVA 856
Score = 55.1 bits (131), Expect = 2e-07
Identities = 47/171 (27%), Positives = 86/171 (50%), Gaps = 32/171 (18%)
Query: 409 RQARLQ-KEQEEQERVEKEEQDRLEREELKRKAEEER----------------------L 445
RQ R+Q K+ ++ + ++ E+D E E + EEE L
Sbjct: 296 RQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFL 355
Query: 446 RLEEEARKQEEERKRQEEEKKKQEGEEKRK--AGEEAKRKAEEELLLKEKQEQEKQEKAM 503
RL+ +++ E +RQ+ E++++E EE ++ E KR E++ + +EQ+++EK
Sbjct: 356 RLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK-- 413
Query: 504 IEKQKEAAETKAREVAEQMRLEREQIMLQIEQE----RLERKKRIDEIMKR 550
E +K+ + R EQMR E E+ + EQE +LE ++R EI+++
Sbjct: 414 -ELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQ 463
Score = 47.4 bits (111), Expect = 5e-05
Identities = 35/98 (35%), Positives = 60/98 (61%), Gaps = 11/98 (11%)
Query: 54 RQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQM-EERWRKLE---EQRQREDQKR 109
R +LA + R E A R QQ LE+Q+R ++++Q+ ER +++E EQR+R ++++
Sbjct: 356 RLQLANKERSE-----ALRRQQ-LEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQ 409
Query: 110 AAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKY 147
+E RKQ+ RE+ E MRR ER ++ E +++Y
Sbjct: 410 RREKELRKQQEREQRRHYEEQMRREEER-RRAEHEQEY 446
Score = 45.8 bits (107), Expect = 1e-04
Identities = 37/154 (24%), Positives = 75/154 (48%), Gaps = 8/154 (5%)
Query: 415 KEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKR 474
++Q + +V + +D ++R + KR ++E E E EEE +EE +
Sbjct: 290 RDQPNERQVRIQLKDHIDRTKKKRGEKDET---EYEYSGSEEE---EEENDSGEPSSILN 343
Query: 475 KAGEEAKRKAEEELLLKEKQEQEKQEKAMIE-KQKEAAETKAREVAE-QMRLEREQIMLQ 532
GE R+ L L K+ E + +E +Q+E E K + +AE Q R+E ++ +
Sbjct: 344 LPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRR 403
Query: 533 IEQERLERKKRIDEIMKRTRKSDVPPQVKKEDPK 566
+E+ R+K + + +R ++ Q+++E+ +
Sbjct: 404 RLEEQQRREKELRKQQEREQRRHYEEQMRREEER 437
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 80.9 bits (198), Expect = 4e-15
Identities = 54/199 (27%), Positives = 114/199 (57%), Gaps = 14/199 (7%)
Query: 406 EKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEK 465
+K+R+ R + ++ E++R E+E+Q + RE+ +RK ++E+ + E + R + E +K++E ++
Sbjct: 63 KKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKE 122
Query: 466 KKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLE 525
+++E +++R+ + +RK + K ++E+ K+E+ +++KE E K E+ R E
Sbjct: 123 RERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKK----RERNRKE 178
Query: 526 REQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKEDPKVGVQPAVCVEKKTKLVVPN 585
R++ E+ER ER++R E K RK + +K+D K Q V + + N
Sbjct: 179 RKK-----ERERKERRERKKERKKERRKK----KERKKDRKTDRQTDSQVFRPLRESAFN 229
Query: 586 KMEINGLNTCQEVN-GVDH 603
++ + G+ + + G+DH
Sbjct: 230 RVTVTGVFRYRIFHTGLDH 248
Score = 79.3 bits (194), Expect = 1e-14
Identities = 45/164 (27%), Positives = 99/164 (60%), Gaps = 6/164 (3%)
Query: 406 EKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEE----ARKQEEERKRQ 461
E+R + + ++E+E++ + E+ ++++ +R++ +R E ER R E E R+++E RKR+
Sbjct: 39 ERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRK 98
Query: 462 EEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQ 521
+E+KK++ + R+ ++ K + E E K+++E++++++ +++KE K R E+
Sbjct: 99 KEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRER 158
Query: 522 MRLER--EQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKE 563
R +R E+ + E+ R ERKK + +R RK + + +K+
Sbjct: 159 KRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKK 202
Score = 70.5 bits (171), Expect = 5e-12
Identities = 52/229 (22%), Positives = 110/229 (48%), Gaps = 57/229 (24%)
Query: 327 QDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAA 386
++ KRK E+EK K G K +K GK
Sbjct: 41 REREKRKREREKERKRERG---------------------KKEKKKRKKRERGK------ 73
Query: 387 LGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLR 446
+R + R ++E++ +ER EKE + R ++E K++ ++R R
Sbjct: 74 --------------------ERERKRKEREKQRKERREKERRKR--KKEKKKRERKQRGR 111
Query: 447 LEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEK 506
E + +K+ +ER+R+ +++++++ +++RK +RK E+E + K+E++++++ E+
Sbjct: 112 RERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKE---RGKRERKRKKRKKEER 168
Query: 507 QKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSD 555
+K+ + E+ R ER + + ++ER ++K+R K+ RK+D
Sbjct: 169 EKKRERNRKERKKERERKERRERKKERKKERRKKKER-----KKDRKTD 212
Score = 69.3 bits (168), Expect = 1e-11
Identities = 47/137 (34%), Positives = 86/137 (62%), Gaps = 12/137 (8%)
Query: 421 ERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEE----EKKKQEGEEKRKA 476
+R + +++R ERE+ KR+ E+ER R E +K++++RK++E E+K++E E++RK
Sbjct: 31 QRESERKKERREREKRKREREKERKR--ERGKKEKKKRKKRERGKERERKRKEREKQRKE 88
Query: 477 GEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQE 536
E +R+ + KEK+++E++++ E++K+ E K RE + R ER++ + ++
Sbjct: 89 RREKERRKRK----KEKKKRERKQRGRRERKKK-KERKERERENKQRRERKRKKRRKKKR 143
Query: 537 RLERKKRIDEIMKRTRK 553
R ER KR E KR RK
Sbjct: 144 RKER-KREKERGKRERK 159
Score = 68.2 bits (165), Expect = 3e-11
Identities = 42/160 (26%), Positives = 97/160 (60%), Gaps = 7/160 (4%)
Query: 408 RRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKK 467
+R++ +KE+ E+E+ ++E + +RE + K E+++ + E +++E +RK +E+++K+
Sbjct: 31 QRESERKKERREREKRKREREKERKRE--RGKKEKKKRKKRERGKERERKRKEREKQRKE 88
Query: 468 QEGEEKRKAGEEAKRKAEEELLLKE-KQEQEKQEKAMIEKQKEAAETKAREVAEQMRLER 526
+ +E+RK +E K++ ++ +E K+++E++E+ KQ+ + K R ++ R ER
Sbjct: 89 RREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRR-KKKRRKER 147
Query: 527 EQIMLQIEQERLERKKRIDEIMK---RTRKSDVPPQVKKE 563
++ + ++ER +K++ +E K R RK + +KE
Sbjct: 148 KREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKE 187
Score = 62.4 bits (150), Expect = 1e-09
Identities = 45/184 (24%), Positives = 88/184 (47%), Gaps = 51/184 (27%)
Query: 326 GQDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSA 385
G++ +++ E+EK KER E+ K +K E+
Sbjct: 72 GKERERKRKEREKQRKERR------------EKERRKRKKEKKKRER------------- 106
Query: 386 ALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERL 445
K+R R +K+++E++ E+E + R ER+ KR+ ++ R
Sbjct: 107 ---------------------KQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRR- 144
Query: 446 RLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIE 505
+ RK+E+ER ++E ++KK++ EE+ K E +++ ++E KE++E++K+ K
Sbjct: 145 ----KERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERR 200
Query: 506 KQKE 509
K+KE
Sbjct: 201 KKKE 204
Score = 56.2 bits (134), Expect = 1e-07
Identities = 32/118 (27%), Positives = 69/118 (58%), Gaps = 1/118 (0%)
Query: 29 EPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYE 88
E G + R +G E K ER++ KERRE +E+ +E++ E+++R R + +
Sbjct: 57 ERGKKEKKKRKKRERGKERERKRKEREKQRKERRE-KERRKRKKEKKKRERKQRGRRERK 115
Query: 89 KQMEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
K+ E + R+ E +++RE +++ ++KR+++ + E+ER + +R + ++ E K++
Sbjct: 116 KKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRE 173
Score = 55.5 bits (132), Expect = 2e-07
Identities = 41/127 (32%), Positives = 71/127 (55%), Gaps = 11/127 (8%)
Query: 447 LEEEARKQEEERKRQEEE----KKKQEGEEKRKAGEEAKRKAEEELLLKEKQ----EQEK 498
+ + ++E ERK++ E K+++E E KR+ G++ K+K ++ KE++ E+EK
Sbjct: 25 ISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREK 84
Query: 499 QEKAMIEKQ--KEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDV 556
Q K EK+ K E K RE ++ R ER++ + E+ER E K+R + K+ RK
Sbjct: 85 QRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERER-ENKQRRERKRKKRRKKKR 143
Query: 557 PPQVKKE 563
+ K+E
Sbjct: 144 RKERKRE 150
Score = 52.4 bits (124), Expect = 2e-06
Identities = 30/96 (31%), Positives = 62/96 (64%), Gaps = 3/96 (3%)
Query: 53 ERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAV 112
ER++ +ER +ER++ +E++ +K++R + + E++ +ER ++ +E+R++E +KR
Sbjct: 42 EREKRKREREKERKRERGKKEKKKRKKRERGK-ERERKRKEREKQRKERREKERRKRKKE 100
Query: 113 EEKRKQKLREEEERLEAMMRRSLER--TQQLELKKK 146
++KR++K R ER + R+ ER Q+ E K+K
Sbjct: 101 KKKRERKQRGRRERKKKKERKERERENKQRRERKRK 136
Score = 51.2 bits (121), Expect = 3e-06
Identities = 33/105 (31%), Positives = 61/105 (58%), Gaps = 9/105 (8%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEE---QRQRED 106
K + +QR +ER++++E+ RE + ++KR + + +K+ +ER R+ E +R+R+
Sbjct: 103 KRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKK 162
Query: 107 QKRAAVEEKR------KQKLREEEERLEAMMRRSLERTQQLELKK 145
+K+ E+KR ++K RE +ER E R ER ++ E KK
Sbjct: 163 RKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKK 207
Score = 47.8 bits (112), Expect = 4e-05
Identities = 32/124 (25%), Positives = 66/124 (53%), Gaps = 5/124 (4%)
Query: 26 KIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARL 85
K E G R + R + + + + R+R ++++ ER++ R ++ +K+++ R
Sbjct: 67 KKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQ--RGRRERKKKKERKERE 124
Query: 86 QYEKQMEERWRKLEEQRQREDQKRAAVE---EKRKQKLREEEERLEAMMRRSLERTQQLE 142
+ KQ ER RK +++R +++ E +RK+K R++EER + R ER ++ E
Sbjct: 125 RENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERE 184
Query: 143 LKKK 146
K++
Sbjct: 185 RKER 188
Score = 47.0 bits (110), Expect = 6e-05
Identities = 25/93 (26%), Positives = 57/93 (61%), Gaps = 1/93 (1%)
Query: 55 QRLAKERREEREKCLAAREQQILEKQKRARLQYEKQME-ERWRKLEEQRQREDQKRAAVE 113
QR ++ ++E RE+ RE++ K++R + + +K+ + ER ++ E +R+ +++R
Sbjct: 31 QRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERR 90
Query: 114 EKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
EK ++K ++E+++ E R ER ++ E K++
Sbjct: 91 EKERRKRKKEKKKRERKQRGRRERKKKKERKER 123
Score = 44.7 bits (104), Expect = 3e-04
Identities = 22/91 (24%), Positives = 51/91 (56%)
Query: 52 DERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAA 111
+ +QR ++R++ R+K ++ E+ KR R + +++ EER +K E R+ ++R
Sbjct: 126 ENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERER 185
Query: 112 VEEKRKQKLREEEERLEAMMRRSLERTQQLE 142
E + ++K R++E R + ++ + +Q +
Sbjct: 186 KERRERKKERKKERRKKKERKKDRKTDRQTD 216
Score = 42.4 bits (98), Expect = 0.002
Identities = 24/95 (25%), Positives = 56/95 (58%), Gaps = 2/95 (2%)
Query: 34 RTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEE 93
R + Q E K +++ KER+ E+E+ R+++ +K++R + + E+ +E
Sbjct: 120 RKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKR-ERNRKE 178
Query: 94 RWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLE 128
R +K E+++R ++K+ +E+RK+K R+++ + +
Sbjct: 179 R-KKERERKERRERKKERKKERRKKKERKKDRKTD 212
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 80.5 bits (197), Expect = 5e-15
Identities = 50/170 (29%), Positives = 103/170 (60%), Gaps = 15/170 (8%)
Query: 399 EAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEER 458
E +I +K + +K ++++E+V ++E+ ++EE R+ EE+ R EE+ R+QEE+
Sbjct: 473 EQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKI 532
Query: 459 KRQEEEKKKQE----------GEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQK 508
+ QEE+ ++QE GE++ K E+ K + +EE ++E++E+ +++K I +Q+
Sbjct: 533 REQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEE-KIREQEEKIREQKEKIREQE 591
Query: 509 E---AAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSD 555
E E K RE E+M E+E+ M + E++ E+++++ E ++ R+ +
Sbjct: 592 EKIWEQEEKIRE-QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQE 640
Score = 78.2 bits (191), Expect = 3e-14
Identities = 65/263 (24%), Positives = 139/263 (52%), Gaps = 37/263 (14%)
Query: 335 EKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTAGT 394
EKE+ +E E + +Q + EE K E+ + E A + +
Sbjct: 374 EKEEKIRELEEKMHEQEKIREQEE--------KRQEEEKIREQEKRQEQEAKMWRQEEKI 425
Query: 395 TDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEE-----------E 443
+ E KI ++++ R +++ EQE++ +EE+ R E+EE+ R+ E+ E
Sbjct: 426 REQEE--KIREQEKKMWRQEEKIHEQEKI-REEEKRQEQEEMWRQEEKIREQEEIWRQKE 482
Query: 444 RLRLEEEARKQEEERKRQEE-----EKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEK 498
++ +E+ RKQEE+ RQEE E+K +E EEK EE R+ EE+ ++E++E+ +
Sbjct: 483 KMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEK--IREQEEKIR 540
Query: 499 QEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPP 558
+++ M+++Q+E + ++ EQ ++ R++ ++ ++E++ +K ++I ++ K
Sbjct: 541 EQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQK--EKIREQEEK----- 593
Query: 559 QVKKEDPKVGVQPAVCVEKKTKL 581
+ +++ K+ Q + E++ K+
Sbjct: 594 -IWEQEEKIREQEEMMQEQEEKM 615
Score = 74.3 bits (181), Expect = 4e-13
Identities = 63/201 (31%), Positives = 111/201 (55%), Gaps = 25/201 (12%)
Query: 399 EAAKILAEKRRQARLQKEQ--EEQERVEKEEQDRLEREELKRKAEE------ERLR-LEE 449
E + + E+ + R Q+E E++E++ ++E+ E+EE R+ EE E++R LEE
Sbjct: 325 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEE 384
Query: 450 EARKQ----EEERKRQEEEK-----KKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQE 500
+ +Q E+E KRQEEEK K+QE E K EE R+ EE++ +EK+ ++E
Sbjct: 385 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEE 444
Query: 501 KAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQV 560
K I +Q++ E + R+ E+M + E+I EQE + R+K ++ RK + +V
Sbjct: 445 K--IHEQEKIREEEKRQEQEEMWRQEEKIR---EQEEIWRQKEKMHEQEKIRKQE--EKV 497
Query: 561 KKEDPKVGVQPAVCVEKKTKL 581
+++ K+ Q E++ K+
Sbjct: 498 WRQEEKMHDQEEKIREQEEKM 518
Score = 72.8 bits (177), Expect = 1e-12
Identities = 54/225 (24%), Positives = 121/225 (53%), Gaps = 18/225 (8%)
Query: 331 KRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKP 390
+ K +++ +E E Q+ Q E+ E+ + + + H K E + +
Sbjct: 443 EEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEK--VWRQ 500
Query: 391 TAGTTDAGEAAKILAEK--RRQARLQKEQE---EQERVEKEEQDRLEREELKRKAEEERL 445
D E + EK R++ ++++++E EQE +E+++ ++ +E K +EE++
Sbjct: 501 EEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKM 560
Query: 446 RLEEEARKQEEERKRQEE---EKKKQEGEEKRKAGEEAKRKAEEELLLKEKQE-----QE 497
+ +E+ R+QEE+ + QEE E+K++ E++ K E+ ++ E+E +++E++E +E
Sbjct: 561 QEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEE 620
Query: 498 K---QEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLE 539
K QE+ M E++++ + + +++RL +++ +Q QE LE
Sbjct: 621 KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 665
Score = 69.7 bits (169), Expect = 9e-12
Identities = 51/182 (28%), Positives = 96/182 (52%), Gaps = 5/182 (2%)
Query: 400 AAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERK 459
+AK+ A+ + ++QE ++++++ E K + +EE++R +EE +++EE+
Sbjct: 278 SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKM 337
Query: 460 RQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVA 519
R++EE E EEK + EE + EE++ E+ EK+EK ++K + K RE
Sbjct: 338 RRQEE-MMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIRE-Q 395
Query: 520 EQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKK---EDPKVGVQPAVCVE 576
E+ R E E+I Q +++ E K E R ++ + Q KK ++ K+ Q + E
Sbjct: 396 EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREE 455
Query: 577 KK 578
+K
Sbjct: 456 EK 457
Score = 68.9 bits (167), Expect = 2e-11
Identities = 65/264 (24%), Positives = 138/264 (52%), Gaps = 24/264 (9%)
Query: 323 ALSGQDMPKRKAEK--EKSNKEREG--------TLAQQAAGPQGEEALEK-HVVDKHASE 371
ALS K+KA++ E+ KER+ T+ + + + EK +V+ SE
Sbjct: 180 ALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSE 239
Query: 372 --KHAAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQE---RVEKE 426
+ K E + L +A K L A+LQ + EE E R+ ++
Sbjct: 240 IQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSV--SAKLQAQVEENELWNRLNQQ 297
Query: 427 EQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEE 486
+++++ R+E K + EE+++ E+E + +E+E K +E+E+K + EE EE K + +E
Sbjct: 298 QEEKMWRQEEKIQEWEEKIQ-EQEEKIREQEEKIREQEEKMRRQEEMMWEKEE-KMRRQE 355
Query: 487 ELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDE 546
E++ +++++ + E+ M EK+++ E + ++ EQ ++ ++ Q E++ E++KR ++
Sbjct: 356 EMMWEKEEKMRRLEEMMWEKEEKIRELE-EKMHEQEKIREQEEKRQEEEKIREQEKRQEQ 414
Query: 547 IMKRTRKSDVPPQVKKEDPKVGVQ 570
K R+ + ++++++ K+ Q
Sbjct: 415 EAKMWRQEE---KIREQEEKIREQ 435
Score = 68.6 bits (166), Expect = 2e-11
Identities = 43/167 (25%), Positives = 97/167 (58%), Gaps = 12/167 (7%)
Query: 408 RRQARLQ----KEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEE 463
R++ ++Q K QE++E++ ++E+ E+EE R+ EE EE+ R+QEE +EE
Sbjct: 304 RQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 363
Query: 464 EKKKQE---GEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAE 520
+ ++ E E++ K E ++ E+E + +++++++++EK +++++ E K E
Sbjct: 364 KMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE 423
Query: 521 QMRLEREQIMLQ-----IEQERLERKKRIDEIMKRTRKSDVPPQVKK 562
++R + E+I Q ++E++ +++I E KR + ++ Q +K
Sbjct: 424 KIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK 470
Score = 68.6 bits (166), Expect = 2e-11
Identities = 56/206 (27%), Positives = 109/206 (52%), Gaps = 30/206 (14%)
Query: 406 EKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEE------ERLRLEEEARKQEEERK 459
E++ Q +K QE++E++ ++E+ E+EE R+ EE E++R +EE ++EE+
Sbjct: 306 EEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKM 365
Query: 460 RQ------EEEKKKQEGEEKRKAGE-----EAKRKAEEELLLKEKQEQEKQEKAMIEKQK 508
R+ E+E+K +E EEK E E KR+ EE++ +EK+++++ + E++
Sbjct: 366 RRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKI 425
Query: 509 EAAETKAREVAEQMRLEREQIMLQ---------IEQERL----ERKKRIDEIMKRTRKSD 555
E K RE ++M + E+I Q EQE + E+ + +EI ++ K
Sbjct: 426 REQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMH 485
Query: 556 VPPQVKKEDPKVGVQPAVCVEKKTKL 581
+++K++ KV Q +++ K+
Sbjct: 486 EQEKIRKQEEKVWRQEEKMHDQEEKI 511
Score = 52.0 bits (123), Expect = 2e-06
Identities = 34/104 (32%), Positives = 61/104 (58%), Gaps = 5/104 (4%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEK--QMEERWRKLEEQRQ 103
E + +E+ R +E+ E+E+ + +E+ + EK+++ R Q E + EE+ R+LEE
Sbjct: 314 EKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMW 373
Query: 104 REDQKRAAVEEK--RKQKLREEEE-RLEAMMRRSLERTQQLELK 144
+++K +EEK ++K+RE+EE R E R E+ Q+ E K
Sbjct: 374 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAK 417
Score = 49.3 bits (116), Expect = 1e-05
Identities = 23/100 (23%), Positives = 60/100 (60%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKR 109
+ +E+ R +E+ E+EK + +E++I E++K + ++ EE WR+ E+ R++E+ R
Sbjct: 420 RQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWR 479
Query: 110 AAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
+ ++K+R++EE++ + ++ +++ +++ W
Sbjct: 480 QKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMW 519
Score = 47.8 bits (112), Expect = 4e-05
Identities = 31/107 (28%), Positives = 62/107 (57%), Gaps = 9/107 (8%)
Query: 43 QGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEK--QMEERWRKLEE 100
Q E + E + +E+ +E+ + +E++I E++++ R Q EK + EE+ R+ EE
Sbjct: 547 QEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEE 606
Query: 101 QRQREDQKRAAVEEK---RKQKLREEEERLEAMMRRSLERTQQLELK 144
Q +++K EEK +++K++E+EE+ MRR E+ + E++
Sbjct: 607 MMQEQEEKMWEQEEKMCEQEEKMQEQEEK----MRRQEEKMWEQEVR 649
Score = 47.4 bits (111), Expect = 5e-05
Identities = 26/99 (26%), Positives = 63/99 (63%), Gaps = 6/99 (6%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKR 109
+ +E + +E+R+E+E + +E++I E++++ R Q +K + + E+++ RE++KR
Sbjct: 399 RQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKR 458
Query: 110 AAVEE--KRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
EE ++++K+RE+EE + R+ + +Q +++K+
Sbjct: 459 QEQEEMWRQEEKIREQEE----IWRQKEKMHEQEKIRKQ 493
Score = 47.0 bits (110), Expect = 6e-05
Identities = 37/148 (25%), Positives = 71/148 (47%), Gaps = 6/148 (4%)
Query: 331 KRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKP 390
K + ++EK ++ E Q+ + EE + + EK E + +
Sbjct: 524 KIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQ 583
Query: 391 TAGTTDAGEAAKILAEKRRQARLQKE--QEEQERVEKEEQDRLEREELKRKAEEERLRLE 448
+ E + E+ + R Q+E QE++E++ ++E+ E+EE K + +EE++R +
Sbjct: 584 KEKIREQEEK---IWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE-KMQEQEEKMRRQ 639
Query: 449 EEARKQEEERKRQEEEKKKQEGEEKRKA 476
EE ++E R RQ+EEK ++ E A
Sbjct: 640 EEKMWEQEVRLRQQEEKMQEHQEHLEAA 667
Score = 46.2 bits (108), Expect = 1e-04
Identities = 25/105 (23%), Positives = 62/105 (59%), Gaps = 5/105 (4%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQME-ERWRKLEEQRQR 104
E + +E+ R +E+ E+E+ + +E+ + E++++ Q EK E E+ R+ EE+ +
Sbjct: 516 EKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIRE 575
Query: 105 EDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
+++K ++K+K+RE+EE++ + E+ + ++ +++ W
Sbjct: 576 QEEK----IREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMW 616
Score = 45.4 bits (106), Expect = 2e-04
Identities = 29/107 (27%), Positives = 64/107 (59%), Gaps = 7/107 (6%)
Query: 43 QGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEK--QMEERWRKLEE 100
Q E + +E+ + +E+ +E+E+ + +E++I E++++ R Q E + EE+ R+ EE
Sbjct: 297 QQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEE 356
Query: 101 QRQREDQKRAAVEE---KRKQKLREEEERL--EAMMRRSLERTQQLE 142
+++K +EE ++++K+RE EE++ + +R E+ Q+ E
Sbjct: 357 MMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEE 403
Score = 45.4 bits (106), Expect = 2e-04
Identities = 28/105 (26%), Positives = 59/105 (56%), Gaps = 5/105 (4%)
Query: 43 QGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYE---KQMEERWRKLE 99
Q E + +E+ R +E+ E+++ + +E++I E++++ R Q E +Q E+ W + E
Sbjct: 561 QEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEE 620
Query: 100 EQRQREDQKRAAVEEKRKQ--KLREEEERLEAMMRRSLERTQQLE 142
+ ++E++ + E+ R+Q K+ E+E RL + E + LE
Sbjct: 621 KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 665
Score = 44.7 bits (104), Expect = 3e-04
Identities = 31/127 (24%), Positives = 70/127 (55%), Gaps = 12/127 (9%)
Query: 26 KIAEPGAVRTSQPNYRPQGM---EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKR 82
KI E +R + + M E ++ E KE+ E+EK + +E+++ ++++
Sbjct: 445 KIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEK-IRKQEEKVWRQEEK 503
Query: 83 ARLQYEK---QMEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQ 139
Q EK Q E+ WR+ E+ R++E++ R ++++K+RE+EE ++ + E+ +
Sbjct: 504 MHDQEEKIREQEEKMWRQEEKIREQEEKIR-----EQEEKIREQEEMMQEQEEKMGEQEE 558
Query: 140 QLELKKK 146
+++ ++K
Sbjct: 559 KMQEQEK 565
Score = 44.3 bits (103), Expect = 4e-04
Identities = 26/97 (26%), Positives = 60/97 (61%), Gaps = 5/97 (5%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKR 109
+ +E+ R +E E+E+ + E+++ E++K R Q EK+ EE K+ EQ +R++Q+
Sbjct: 360 EKEEKMRRLEEMMWEKEEKIRELEEKMHEQEK-IREQEEKRQEE--EKIREQEKRQEQE- 415
Query: 110 AAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
A ++++K+RE+EE++ ++ + +++ ++K
Sbjct: 416 -AKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEK 451
Score = 44.3 bits (103), Expect = 4e-04
Identities = 26/100 (26%), Positives = 60/100 (60%), Gaps = 8/100 (8%)
Query: 49 LKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEK--QMEERWRKLEEQRQRED 106
++ E+ R +E+ E+E+ + ++++I E++++ Q EK + EE ++ EE+ ++
Sbjct: 560 MQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQE 619
Query: 107 QKRAAVEEK---RKQKLREEEERL---EAMMRRSLERTQQ 140
+K EEK +++K+R +EE++ E +R+ E+ Q+
Sbjct: 620 EKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 659
Score = 43.5 bits (101), Expect = 7e-04
Identities = 23/113 (20%), Positives = 64/113 (56%), Gaps = 9/113 (7%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRAR----LQYEKQ-----MEERWR 96
E + +E+ R +E E+E+ + +E+ + EK+++ R + +EK+ +EE+
Sbjct: 328 EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMH 387
Query: 97 KLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
+ E+ R++E++++ + + ++K +E+E ++ + E+ +++ ++K W
Sbjct: 388 EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMW 440
Score = 43.5 bits (101), Expect = 7e-04
Identities = 26/113 (23%), Positives = 62/113 (54%), Gaps = 13/113 (11%)
Query: 50 KSDERQRLAKERRE--EREKCLAAREQQILEKQKRARLQYEK---------QMEERWRKL 98
K E++++ K+ + +E+ + +E++I E++++ Q EK + EE+ R+
Sbjct: 483 KMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQ 542
Query: 99 EEQRQREDQKRAAVEEK--RKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
EE Q +++K EEK ++K+R +EE++ + E+ +++ +++ W
Sbjct: 543 EEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIW 595
Score = 42.7 bits (99), Expect = 0.001
Identities = 29/99 (29%), Positives = 57/99 (57%), Gaps = 6/99 (6%)
Query: 45 MEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQR 104
+E + E+ R +E+R+E EK REQ+ ++Q+ + E+++ E+ K+ EQ ++
Sbjct: 382 LEEKMHEQEKIREQEEKRQEEEK---IREQEKRQEQEAKMWRQEEKIREQEEKIREQEKK 438
Query: 105 EDQKRAAVEEKRKQKLREEEERLE-AMMRRSLERTQQLE 142
++ + E ++K+REEE+R E M R E+ ++ E
Sbjct: 439 MWRQEEKIHE--QEKIREEEKRQEQEEMWRQEEKIREQE 475
Score = 42.4 bits (98), Expect = 0.002
Identities = 28/88 (31%), Positives = 50/88 (56%), Gaps = 3/88 (3%)
Query: 59 KERREEREKCLAAREQQILEKQKRARLQYEK--QMEERWRKLEEQRQREDQKRAAVEEKR 116
+E+ +E+ + E++I E++++ R Q EK + EE+ R+ EE +++K EE
Sbjct: 299 EEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMM 358
Query: 117 KQKLREEEERLEAMMRRSLERTQQLELK 144
+K E+ RLE MM E+ ++LE K
Sbjct: 359 WEK-EEKMRRLEEMMWEKEEKIRELEEK 385
Score = 41.2 bits (95), Expect = 0.003
Identities = 27/108 (25%), Positives = 64/108 (59%), Gaps = 7/108 (6%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYE-KQMEERWRKLEEQRQR 104
E + +E+ R +E +E+E+ + +E+++ E++K R + + ++ EE+ R+ +E+ +
Sbjct: 530 EKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIRE 589
Query: 105 EDQKRAAVEEK---RKQKLREEEERL---EAMMRRSLERTQQLELKKK 146
+++K EEK +++ ++E+EE++ E M E+ Q+ E K +
Sbjct: 590 QEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMR 637
Score = 40.8 bits (94), Expect = 0.005
Identities = 20/102 (19%), Positives = 61/102 (59%), Gaps = 8/102 (7%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQRE 105
E + +E+ R +E+ E+E+ + +E+++ E++++ +Q +++M + K+ EQ ++
Sbjct: 523 EKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEK--MQEQEKMRRQEEKIREQEEKI 580
Query: 106 DQKRAAVEE------KRKQKLREEEERLEAMMRRSLERTQQL 141
+++ + E ++++K+RE+EE ++ + E+ +++
Sbjct: 581 REQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKM 622
Score = 40.4 bits (93), Expect = 0.006
Identities = 24/94 (25%), Positives = 55/94 (58%), Gaps = 3/94 (3%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKR 109
+ +E+ R +E+ E+EK E++ E++ R + + ++Q + WR+ E+ R++E++ R
Sbjct: 374 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 433
Query: 110 AAVEEKRKQKLREEEERLEAMMRRSLERTQQLEL 143
E+++K +EE+ + +R +R +Q E+
Sbjct: 434 ---EQEKKMWRQEEKIHEQEKIREEEKRQEQEEM 464
Score = 39.3 bits (90), Expect = 0.013
Identities = 31/105 (29%), Positives = 55/105 (52%), Gaps = 18/105 (17%)
Query: 60 ERREEREKCLAAREQQILE--------KQKRARLQYEKQMEERWRKLEEQRQ----REDQ 107
+R+ ER K L ++Q E + A+LQ + + E W +L +Q++ R+++
Sbjct: 248 KRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEE 307
Query: 108 KRAAVEEK---RKQKLREEEERL---EAMMRRSLERTQQLELKKK 146
K EEK +++K+RE+EE++ E MRR E + E K +
Sbjct: 308 KIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMR 352
Score = 39.3 bits (90), Expect = 0.013
Identities = 27/104 (25%), Positives = 54/104 (51%), Gaps = 5/104 (4%)
Query: 49 LKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQK 108
L + Q A +E + A + Q+ E + RL ++Q E+ WR+ EE+ Q ++K
Sbjct: 258 LPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLN-QQQEEKMWRQ-EEKIQEWEEK 315
Query: 109 RAAVEEK---RKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
EEK +++K+RE+EE++ E+ +++ +++ W
Sbjct: 316 IQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMW 359
Score = 32.7 bits (73), Expect = 1.2
Identities = 25/104 (24%), Positives = 49/104 (47%), Gaps = 14/104 (13%)
Query: 53 ERQRLAKERREEREKCLAAREQQIL-----EKQKRARLQYEKQMEERWRKLEEQRQREDQ 107
E L KE + K A E+ L ++Q+ + E++++E K++EQ ++ +
Sbjct: 266 EADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE 325
Query: 108 KRAAVEEKRKQKLREEE---------ERLEAMMRRSLERTQQLE 142
+ + E+ ++ R+EE R E MM E+ ++LE
Sbjct: 326 QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLE 369
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 80.5 bits (197), Expect = 5e-15
Identities = 44/151 (29%), Positives = 93/151 (61%), Gaps = 3/151 (1%)
Query: 405 AEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEE 464
+E R+ +L +EQ+ +E+ E + Q ER++ + +E+R RLEE+ R++ E R++QE E
Sbjct: 367 SEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQERE 426
Query: 465 KKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEK--QEKAMIEKQKEAAETKAREVAEQM 522
++++E EEKR+ E +R+ EEE + ++E+ + +E+ I +Q E E + EV +Q
Sbjct: 427 QRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLE-EEQRHLEVLQQQ 485
Query: 523 RLEREQIMLQIEQERLERKKRIDEIMKRTRK 553
L+ + ++L+ +E ++ + + ++ ++
Sbjct: 486 LLQEQAMLLECRWREMEEHRQAERLQRQLQQ 516
Score = 79.7 bits (195), Expect = 9e-15
Identities = 68/262 (25%), Positives = 128/262 (48%), Gaps = 29/262 (11%)
Query: 331 KRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKP 390
K++ EK+++ E G+ ++ P+ E + +S + + L +
Sbjct: 311 KKRGEKDETEYEYSGSEEEEEEVPEQE--------GEPSSIVNVPGESTLRRDFLRLQQE 362
Query: 391 TAGTTDAGEAAKILAEKR-RQARLQKEQ---EEQERVEKEEQDRLEREELKRKAEEERLR 446
++A ++L E++ R+ K Q E Q+R+E++++ R EE +R+ E R +
Sbjct: 363 NKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQ 422
Query: 447 LEEEARKQE-EERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQ------ 499
E E R++E EE++R EE +++++ EE+R+ EE KR+ E E +Q +E+Q
Sbjct: 423 QEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVL 482
Query: 500 EKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQ 559
++ ++++Q E + RE+ E + ER Q LQ EQ L + D + S PP
Sbjct: 483 QQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQH-DHRRPHPQHSQQPPP 541
Query: 560 VKKE---------DPKVGVQPA 572
++E +PK +PA
Sbjct: 542 PQQERSKPSFHAPEPKAHYEPA 563
Score = 70.5 bits (171), Expect = 5e-12
Identities = 120/540 (22%), Positives = 204/540 (37%), Gaps = 100/540 (18%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKR 109
+ ++R+RL +++R ERE AR QQ E+++R R Q EK+ R +LE +R+ E+++R
Sbjct: 402 QKEQRRRLEEQQRRERE----ARRQQ--EREQRRREQEEKR---RLEELERRRKEEEERR 452
Query: 110 AAVEEKR---------KQKLREEEERLEAMMR--------------RSLERTQQLELKKK 146
A EEKR +++L EE+ LE + + R +E +Q E ++
Sbjct: 453 RAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQR 512
Query: 147 YSWGAPLAIGPGGHDACDKLSTSTMSLPKPTEPPMNKRLSSSTVAISYSP-DRVFHVCPR 205
+ HD + P P + + Y P DR V R
Sbjct: 513 QLQQEQAYLLSLQHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDR 572
Query: 206 LAPLGPLNPSYKSSPTRNIEKKKATSTSTSGAGDVGKEALSGGEASLVEKVKRGQRTATS 265
+P +S T + + S S E+ S G + V QR A
Sbjct: 573 FRKTNHSSPEAQSKQTGRVLEPPVPSRS---------ESFSNGNSESVHPAL--QRPAEP 621
Query: 266 -------LPVVNFGSPLRRC-EFSGGIPK------------RPS-SPVISKTA------- 297
+ N SP+ R FS PK PS S V+S+++
Sbjct: 622 QVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQDPCPPSRSEVLSQSSDSKSEAP 681
Query: 298 ---TKAYPQSPKTTKPPYPGSPVKYRLPALSGQDMPKRKAEKEKSNKEREGTLAQQAAGP 354
KA+ +S PP R P LS +D P + + ++ S Q+ +
Sbjct: 682 DPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRDSPLQGSGQQNSQ------AGQRNSTS 735
Query: 355 QGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQ 414
E L V+K + ++ G + + + G + +GE ++ + + +
Sbjct: 736 SIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEG--S 793
Query: 415 KEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEER---------------- 458
Q + V+K E + LK E + L +E R E+ R
Sbjct: 794 PSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSEESG 853
Query: 459 -KRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKARE 517
+E++ +QEG ++ +G E R A L + E K + + E A T ++E
Sbjct: 854 TTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKE 913
Score = 54.7 bits (130), Expect = 3e-07
Identities = 45/174 (25%), Positives = 92/174 (52%), Gaps = 24/174 (13%)
Query: 409 RQARLQ-KEQEEQERVEKEEQDRLEREELKRKAEEERLRLEE-----------EARKQEE 456
RQ R+Q K+ ++ R ++ E+D E E + EEE + +E E+ + +
Sbjct: 296 RQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRD 355
Query: 457 ERKRQEEEKKKQEGEEKRKAGEEAKRKAEEEL---LLKEKQ----EQEKQEKAMIEKQKE 509
+ Q+E K++ E +++ +E + + +EE LL E+Q +Q++Q + + E+Q+
Sbjct: 356 FLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRR 415
Query: 510 AAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKE 563
E + ++ EQ R E+E+ + E LER+++ +E +R R + +V++E
Sbjct: 416 EREARRQQEREQRRREQEE---KRRLEELERRRKEEE--ERRRAEEEKRRVERE 464
Score = 52.8 bits (125), Expect = 1e-06
Identities = 32/103 (31%), Positives = 62/103 (60%), Gaps = 12/103 (11%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQIL-EKQKRARLQYEKQM-----------EERWRK 97
+S R+ + ++E +E+ A R QQ+L E+Q R + +Y++Q+ +E+ R+
Sbjct: 349 ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR 408
Query: 98 LEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQ 140
LEEQ++RE + R E +++++ +EE+ RLE + RR E ++
Sbjct: 409 LEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEER 451
Score = 51.6 bits (122), Expect = 3e-06
Identities = 32/95 (33%), Positives = 56/95 (58%), Gaps = 8/95 (8%)
Query: 54 RQRLAKERR----EEREKCLAAREQQILEKQKRARLQYEKQM----EERWRKLEEQRQRE 105
RQ+L +E++ EE ++ L A Q+ +E+QK R + E+Q E R ++ EQR+RE
Sbjct: 372 RQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRRE 431
Query: 106 DQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQ 140
+++ +EE +++ EEE R +R +ER Q+
Sbjct: 432 QEEKRRLEELERRRKEEEERRRAEEEKRRVEREQE 466
Score = 49.3 bits (116), Expect = 1e-05
Identities = 42/173 (24%), Positives = 83/173 (47%), Gaps = 28/173 (16%)
Query: 423 VEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKK--KQEGE--------- 471
+ + +R R +LK + R + E+ + E +EEE++ +QEGE
Sbjct: 289 IRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPG 348
Query: 472 ------------EKRKAGEEAKRKAE--EELLLKEKQEQEKQEKAMIEKQKEAAETKARE 517
++ K EA R+ + +E L+E++E ++Q A +K+ E + + R
Sbjct: 349 ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR 408
Query: 518 VAEQMRLEREQIMLQIEQER---LERKKRIDEIMKRTRKSDVPPQVKKEDPKV 567
+ EQ R ERE Q ++R E K+R++E+ +R ++ + + ++E +V
Sbjct: 409 LEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRV 461
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 79.7 bits (195), Expect = 9e-15
Identities = 52/175 (29%), Positives = 106/175 (60%), Gaps = 6/175 (3%)
Query: 409 RQARLQKEQEEQERVEKE--EQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKK 466
RQ +EQEE R E++ EQ+++ EE +++ E++ R EE+ R+QEE+ RQEE K
Sbjct: 535 RQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEE--K 592
Query: 467 KQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLER 526
+E EEKR+ EE K EE++ +E++ QE++EK +++K + + + E+ E+
Sbjct: 593 IREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQ 652
Query: 527 EQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKEDPKVGVQPAVCVEKKTKL 581
E+ M + E++ E+++ + ++ R+ + ++++++ K+ Q + E++ K+
Sbjct: 653 EEKMCEQEEKMQEQEETMWRQEEKIREQE--KKIREQEEKIREQEEMMQEQEEKM 705
Score = 77.8 bits (190), Expect = 3e-14
Identities = 56/187 (29%), Positives = 116/187 (62%), Gaps = 16/187 (8%)
Query: 404 LAEKRRQARLQKEQEEQERVEKEE-----QDRLEREELKRKAEEERL-RLEEEARKQEEE 457
+ E+ R +++ EQE++ +EE +D++ R+E K + +EE++ R EE+ R+QEE
Sbjct: 540 IREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEE- 598
Query: 458 RKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKE---AAETK 514
KRQE+E+K + EEK + EE ++ EE+ ++E++E+ ++++ M ++Q+E E K
Sbjct: 599 -KRQEQEEKMWKQEEKIREQEEKIQEQEEK--IREQEEKIREQEEMTQEQEEKMGEQEEK 655
Query: 515 AREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKEDPKVGVQPAVC 574
E E+M+ E+E+ M + E++ E++K+I E ++ R+ + +++++ K+ Q
Sbjct: 656 MCEQEEKMQ-EQEETMWRQEEKIREQEKKIREQEEKIREQE--EMMQEQEEKMWEQEEKM 712
Query: 575 VEKKTKL 581
E++ K+
Sbjct: 713 CEQEEKM 719
Score = 77.4 bits (189), Expect = 4e-14
Identities = 54/196 (27%), Positives = 118/196 (60%), Gaps = 16/196 (8%)
Query: 399 EAAKILAEKRRQARL-------QKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEA 451
E KI E++RQ + +K +E++E+V ++E+ E+EE +++ EE+ + EE+
Sbjct: 555 EQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKI 614
Query: 452 RKQEE-----ERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEK 506
R+QEE E K +E+E+K +E EE + EE + EE++ +E++ QE++E ++
Sbjct: 615 REQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQE 674
Query: 507 QK-EAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKEDP 565
+K E K RE E++R E+E++M + E++ E+++++ E ++ ++ + ++++++
Sbjct: 675 EKIREQEKKIREQEEKIR-EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE--EKMRRQEE 731
Query: 566 KVGVQPAVCVEKKTKL 581
K+ Q +++ K+
Sbjct: 732 KMWEQEVRLRQQEEKM 747
Score = 77.0 bits (188), Expect = 6e-14
Identities = 59/188 (31%), Positives = 110/188 (58%), Gaps = 18/188 (9%)
Query: 402 KILAEKRRQARLQKEQ--EEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERK 459
+++ EK + R Q+E E++E++ ++E+ E+EE R+ EE ++ E+ + +E+E K
Sbjct: 356 EMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE---KMHEQEKIREQEEK 412
Query: 460 RQEEEK-----KKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETK 514
RQEEEK K+QE E K EE R+ EE++ +EK+ ++EK I +Q++ E +
Sbjct: 413 RQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEK--IHEQEKIREEE 470
Query: 515 AREVAEQMRLEREQIMLQIEQERLER-KKRIDEIMKRTRKSDVPPQVKKEDPKVGVQPAV 573
R+ E+M + E+I EQE + R K+++ E ++ RK + +V +++ K+ Q
Sbjct: 471 KRQEQEEMWRQEEKIH---EQEEIWRQKEKMHEQEEKIRKQE--EKVWRQEEKIREQEEK 525
Query: 574 CVEKKTKL 581
E++ K+
Sbjct: 526 IREQEEKM 533
Score = 77.0 bits (188), Expect = 6e-14
Identities = 57/257 (22%), Positives = 139/257 (54%), Gaps = 9/257 (3%)
Query: 331 KRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKP 390
+ K ++E+ +E+E Q+A + EE + + EK K + +
Sbjct: 410 EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREE 469
Query: 391 TAGTTDAG---EAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRL 447
+ KI ++ + +K E++E++ K+E +++ R+E K + +EE++R
Sbjct: 470 EKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQE-EKVWRQEEKIREQEEKIRE 528
Query: 448 EEEARKQEEERKRQEEE--KKKQEGEEKRKAGEEAKRKAEEELLLKEKQE-QEKQEKAMI 504
+EE ++EE+ R++EE +++++ E+ K EE KR+ +E+ + +++++ +E++EK
Sbjct: 529 QEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWR 588
Query: 505 EKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKED 564
+++K + + R+ E+ ++E+ + + E++ E++++I E ++ R+ + Q ++E
Sbjct: 589 QEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEE- 647
Query: 565 PKVGVQPAVCVEKKTKL 581
K+G Q E++ K+
Sbjct: 648 -KMGEQEEKMCEQEEKM 663
Score = 74.3 bits (181), Expect = 4e-13
Identities = 68/276 (24%), Positives = 143/276 (51%), Gaps = 34/276 (12%)
Query: 323 ALSGQDMPKRKAEK--EKSNKEREG--------TLAQQAAGPQGEEALEK-HVVDKHASE 371
ALS K+KA++ E+ KER+ T+ + + + EK +V+ SE
Sbjct: 180 ALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSE 239
Query: 372 --KHAAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQE---RVEKE 426
+ K E + L +A K L A+LQ + EE E R+ ++
Sbjct: 240 IQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSV--SAKLQAQVEENELWNRLNQQ 297
Query: 427 EQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQ------EGEEKRKAGEEA 480
+++++ R+E K + EE+++ +EE +++EE+ R++EEK ++ E EEK + EE
Sbjct: 298 QEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEM 357
Query: 481 ------KRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIE 534
K + +EE++ +++++ +QE+ M EK+++ E + ++ EQ ++ ++ Q E
Sbjct: 358 MWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE-EKMHEQEKIREQEEKRQEE 416
Query: 535 QERLERKKRIDEIMKRTRKSDVPPQVKKEDPKVGVQ 570
++ E++KR ++ K R+ + ++++++ K+ Q
Sbjct: 417 EKIREQEKRQEQEAKMWRQEE---KIREQEEKIREQ 449
Score = 70.5 bits (171), Expect = 5e-12
Identities = 49/179 (27%), Positives = 99/179 (55%), Gaps = 9/179 (5%)
Query: 399 EAAKILAEKRRQARLQKEQ--EEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEE 456
E + + E+ + R Q+E E++E++ ++E+ E+EE R+ EE EE+ R+QEE
Sbjct: 325 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEE 384
Query: 457 -----ERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAA 511
E K +E E+K E E+ R+ +E KR+ EE++ +EK+++++ + E++
Sbjct: 385 MMWEKEEKIRELEEKMHEQEKIRE--QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ 442
Query: 512 ETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKEDPKVGVQ 570
E K RE ++M + E+I Q + E+++ +E+ ++ K ++ ++ K+ Q
Sbjct: 443 EEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQ 501
Score = 69.7 bits (169), Expect = 9e-12
Identities = 52/179 (29%), Positives = 102/179 (56%), Gaps = 22/179 (12%)
Query: 406 EKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEE------ERLRLEEEARKQEEERK 459
E++ Q +K QE++E++ ++E+ E+EE R+ EE E++R +EE ++EE+
Sbjct: 306 EEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKM 365
Query: 460 RQEE------EKKKQEGEEKRKAGEEAKRKAEEELLLKEK---QEQEKQEKAMIEKQKEA 510
R++E E+K + EE EE R+ EE++ +EK QE+++QE+ I +Q++
Sbjct: 366 RRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR 425
Query: 511 AETKAR--EVAEQMRLEREQIMLQ-----IEQERLERKKRIDEIMKRTRKSDVPPQVKK 562
E +A+ E++R + E+I Q ++E++ +++I E KR + ++ Q +K
Sbjct: 426 QEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK 484
Score = 67.0 bits (162), Expect = 6e-11
Identities = 35/135 (25%), Positives = 84/135 (62%), Gaps = 4/135 (2%)
Query: 408 RRQARLQKEQEEQERVEKE---EQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEE 464
R Q +EQEE+ R ++E EQ+ + +E+ ++ E+E E+E + QE+E +E
Sbjct: 615 REQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQE 674
Query: 465 KKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRL 524
+K +E E+K + EE K + +EE++ +++++ +QE+ M E++++ E + + ++ ++
Sbjct: 675 EKIREQEKKIREQEE-KIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKM 733
Query: 525 EREQIMLQIEQERLE 539
+++ L+ ++E+++
Sbjct: 734 WEQEVRLRQQEEKMQ 748
Score = 61.2 bits (147), Expect = 3e-09
Identities = 40/128 (31%), Positives = 80/128 (62%), Gaps = 5/128 (3%)
Query: 399 EAAKILAEKRRQARLQKE--QEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEE 456
E + + E+ + R Q+E QE++E++ ++E+ E+EE ++ EE R EE+ R+QE+
Sbjct: 623 EQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEK 682
Query: 457 ERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKE-AAETKA 515
+ R++EEK +++ EE + EE + EE++ +E++ QE++EK +++K E +
Sbjct: 683 -KIREQEEKIREQ-EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL 740
Query: 516 REVAEQMR 523
R+ E+M+
Sbjct: 741 RQQEEKMQ 748
Score = 55.5 bits (132), Expect = 2e-07
Identities = 41/173 (23%), Positives = 81/173 (46%), Gaps = 7/173 (4%)
Query: 331 KRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKP 390
K + ++EK ++ E Q+ + EE + K E+ K +
Sbjct: 578 KIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIRE 637
Query: 391 TAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEE 450
T E K+ ++ + +++ +EQE +++++ +E K + +EE++R +EE
Sbjct: 638 QEEMTQEQEE-KMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEE 696
Query: 451 ARKQEEERKRQEEEK------KKQEGEEKRKAGEEAKRKAEEELLLKEKQEQE 497
+++EE+ ++EEK K QE EEK + EE + E L +E++ QE
Sbjct: 697 MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 51.2 bits (121), Expect = 3e-06
Identities = 31/103 (30%), Positives = 65/103 (63%), Gaps = 8/103 (7%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEK--QMEERWRKLEEQRQREDQ 107
+ +E+ R +E+R+E+E+ + +E++I E++++ + Q EK + EE+ R+ EE Q +++
Sbjct: 588 RQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEE 647
Query: 108 KRAAVEEK---RKQKLREEEE---RLEAMMRRSLERTQQLELK 144
K EEK +++K++E+EE R E +R ++ ++ E K
Sbjct: 648 KMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEK 690
Score = 50.1 bits (118), Expect = 7e-06
Identities = 39/118 (33%), Positives = 67/118 (56%), Gaps = 8/118 (6%)
Query: 33 VRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEK--Q 90
+R + R Q E + +E+ R +E E+E+ + +E+ + EK+++ R Q E +
Sbjct: 330 IREQEEKMRRQE-EMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWE 388
Query: 91 MEERWRKLEEQRQREDQKRAAVEEKR--KQKLREEEER--LEAMMRRSLERTQQLELK 144
EE+ R+LEE + E +K EEKR ++K+RE+E+R EA M R E+ ++ E K
Sbjct: 389 KEEKIRELEE-KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 445
Score = 48.9 bits (115), Expect = 2e-05
Identities = 33/123 (26%), Positives = 67/123 (54%), Gaps = 8/123 (6%)
Query: 26 KIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARL 85
KI E Q + E + +E+ +E+ +E+E+ + +E++I E++K+ R
Sbjct: 627 KIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIRE 686
Query: 86 QYEK--QMEERWRKLEEQRQREDQKRAAVEEK---RKQKLREEEERL---EAMMRRSLER 137
Q EK + EE ++ EE+ +++K EEK +++K+R +EE++ E +R+ E+
Sbjct: 687 QEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 746
Query: 138 TQQ 140
Q+
Sbjct: 747 MQE 749
Score = 48.1 bits (113), Expect = 3e-05
Identities = 30/106 (28%), Positives = 62/106 (58%), Gaps = 9/106 (8%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQME-ERWRKLEEQRQ----- 103
+ +E+ R +E E+E+ + +E+ + EK+++ R EK E E+ R+ EE+RQ
Sbjct: 360 EKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI 419
Query: 104 REDQKRAAVEEK---RKQKLREEEERLEAMMRRSLERTQQLELKKK 146
RE +KR E K +++K+RE+EE++ ++ + +++ ++K
Sbjct: 420 REQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEK 465
Score = 48.1 bits (113), Expect = 3e-05
Identities = 32/102 (31%), Positives = 64/102 (62%), Gaps = 12/102 (11%)
Query: 50 KSDERQRL-AKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQK 108
K E++++ +E+R+E+E + +E++I E++++ Q EE+ R+ EE+RQ +++K
Sbjct: 552 KMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQ-----EEKIREQEEKRQEQEEK 606
Query: 109 RAAVEEK---RKQKLREEEERL---EAMMRRSLERTQQLELK 144
EEK +++K++E+EE++ E +R E TQ+ E K
Sbjct: 607 MWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEK 648
Score = 47.0 bits (110), Expect = 6e-05
Identities = 29/117 (24%), Positives = 65/117 (55%), Gaps = 12/117 (10%)
Query: 37 QPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEK------- 89
Q R + E K +E+ R +E+ +E+E+ + +E++I E+++ + Q EK
Sbjct: 596 QEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEK 655
Query: 90 --QMEERWRKLEEQRQREDQKRAAVEEK---RKQKLREEEERLEAMMRRSLERTQQL 141
+ EE+ ++ EE R+++K E+K +++K+RE+EE ++ + E+ +++
Sbjct: 656 MCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKM 712
Score = 46.6 bits (109), Expect = 8e-05
Identities = 27/99 (27%), Positives = 60/99 (60%), Gaps = 4/99 (4%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKR 109
+ +E + +E+R+E+E + +E++I E++++ R Q +K + + E+++ RE++KR
Sbjct: 413 RQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKR 472
Query: 110 AAVEE--KRKQKLREEEE--RLEAMMRRSLERTQQLELK 144
EE ++++K+ E+EE R + M E+ ++ E K
Sbjct: 473 QEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEK 511
Score = 46.6 bits (109), Expect = 8e-05
Identities = 32/107 (29%), Positives = 63/107 (58%), Gaps = 12/107 (11%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEK--QMEERWRKLEEQRQRE-- 105
+ +E+ R +E+ +E+ + +E++I E++++ Q EK + EE WR+ E+ ++E
Sbjct: 500 EQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKI 559
Query: 106 --DQKRAAVEEK---RKQKLREEEE---RLEAMMRRSLERTQQLELK 144
++KR E+K +++K+RE+EE R E +R E+ Q+ E K
Sbjct: 560 WEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEK 606
Score = 46.2 bits (108), Expect = 1e-04
Identities = 35/127 (27%), Positives = 65/127 (51%), Gaps = 8/127 (6%)
Query: 26 KIAEPGAVRTSQPNYRPQGM---EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKR 82
KI E +R + + M E + E KE+ E+E+ + +E+++ ++++
Sbjct: 459 KIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEK 518
Query: 83 ARLQYEK---QMEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEA--MMRRSLER 137
R Q EK Q E+ WR+ E+ R++E+ R + ++K+ EEE+R E M R E+
Sbjct: 519 IREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEK 578
Query: 138 TQQLELK 144
++ E K
Sbjct: 579 IREQEEK 585
Score = 45.8 bits (107), Expect = 1e-04
Identities = 23/101 (22%), Positives = 61/101 (60%), Gaps = 1/101 (0%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKR 109
+ +E+ R +E+ E+EK + +E++I E++K + ++ EE WR+ E+ ++E+ R
Sbjct: 434 RQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWR 493
Query: 110 AAVE-EKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
+ ++++K+R++EE++ + E+ +++ +++ W
Sbjct: 494 QKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMW 534
Score = 45.4 bits (106), Expect = 2e-04
Identities = 35/118 (29%), Positives = 62/118 (52%), Gaps = 19/118 (16%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYE----------KQMEERW 95
E + +E+ R +E+ E+E+ + +E+ + EK+++ R Q E +Q E W
Sbjct: 314 EKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMW 373
Query: 96 RKLEEQRQRE------DQKRAAVEEK--RKQKLREEEE-RLEAMMRRSLERTQQLELK 144
K E+ R++E ++K +EEK ++K+RE+EE R E R E+ Q+ E K
Sbjct: 374 EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAK 431
Score = 44.3 bits (103), Expect = 4e-04
Identities = 30/107 (28%), Positives = 62/107 (57%), Gaps = 9/107 (8%)
Query: 43 QGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEK--QMEERWRKLEE 100
Q E + +E+ + +E+ +E+E+ + +E++I E++++ R Q E + EE+ R+ EE
Sbjct: 297 QQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEE 356
Query: 101 QRQREDQKRAAVEE---KRKQKLREEEERLEAMMRRSLERTQQLELK 144
+++K EE ++++K+R +EE MM E+ ++LE K
Sbjct: 357 MMWEKEEKMRRQEEMMWEKEEKMRRQEE----MMWEKEEKIRELEEK 399
Score = 44.3 bits (103), Expect = 4e-04
Identities = 27/105 (25%), Positives = 64/105 (60%), Gaps = 6/105 (5%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEK--QMEERWRKLEEQRQREDQ 107
+ D+ R ++ RE+ EK + +E++I E++++ + Q EK + EE+ R+ EE+ Q +++
Sbjct: 568 QEDKMWRQEEKIREQEEK-VWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEE 626
Query: 108 KRAAVEEK---RKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
K EEK +++ +E+EE++ + E+ ++++ +++ W
Sbjct: 627 KIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMW 671
Score = 43.9 bits (102), Expect = 5e-04
Identities = 26/120 (21%), Positives = 65/120 (54%), Gaps = 3/120 (2%)
Query: 49 LKSDERQRLAKERREEREKCLAAREQQILE-KQKRARLQYEKQMEERWRKLEEQRQREDQ 107
++ E +E+ E+EK ++Q E K R + +Q E+ WR+ E+ R++E++
Sbjct: 540 IREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEK 599
Query: 108 KRAAVEE--KRKQKLREEEERLEAMMRRSLERTQQLELKKKYSWGAPLAIGPGGHDACDK 165
++ E+ K+++K+RE+EE+++ + E+ +++ +++ + +G C++
Sbjct: 600 RQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQ 659
Score = 42.4 bits (98), Expect = 0.002
Identities = 25/84 (29%), Positives = 50/84 (59%), Gaps = 5/84 (5%)
Query: 45 MEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQR 104
+E + E+ R +E+R+E EK REQ+ ++Q+ + E+++ E+ K+ EQ ++
Sbjct: 396 LEEKMHEQEKIREQEEKRQEEEK---IREQEKRQEQEAKMWRQEEKIREQEEKIREQEKK 452
Query: 105 EDQKRAAVEEKRKQKLREEEERLE 128
++ + E ++K+REEE+R E
Sbjct: 453 MWRQEEKIHE--QEKIREEEKRQE 474
Score = 41.2 bits (95), Expect = 0.003
Identities = 27/114 (23%), Positives = 65/114 (57%), Gaps = 15/114 (13%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYE---------KQMEERWR 96
E + +E+ R +E +E+E+ + +E+++ E++++ + Q E ++ E++ R
Sbjct: 626 EKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIR 685
Query: 97 KLEEQRQREDQKRAAVEEK---RKQKLREEEERL---EAMMRRSLERTQQLELK 144
+ EE+ + +++ EEK +++K+ E+EE++ E MRR E+ + E++
Sbjct: 686 EQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVR 739
Score = 40.4 bits (93), Expect = 0.006
Identities = 24/94 (25%), Positives = 55/94 (58%), Gaps = 3/94 (3%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKR 109
+ +E+ R +E+ E+EK E++ E++ R + + ++Q + WR+ E+ R++E++ R
Sbjct: 388 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 447
Query: 110 AAVEEKRKQKLREEEERLEAMMRRSLERTQQLEL 143
E+++K +EE+ + +R +R +Q E+
Sbjct: 448 ---EQEKKMWRQEEKIHEQEKIREEEKRQEQEEM 478
Score = 39.3 bits (90), Expect = 0.013
Identities = 31/105 (29%), Positives = 55/105 (52%), Gaps = 18/105 (17%)
Query: 60 ERREEREKCLAAREQQILE--------KQKRARLQYEKQMEERWRKLEEQRQ----REDQ 107
+R+ ER K L ++Q E + A+LQ + + E W +L +Q++ R+++
Sbjct: 248 KRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEE 307
Query: 108 KRAAVEEK---RKQKLREEEERL---EAMMRRSLERTQQLELKKK 146
K EEK +++K+RE+EE++ E MRR E + E K +
Sbjct: 308 KIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMR 352
Score = 36.6 bits (83), Expect = 0.085
Identities = 32/125 (25%), Positives = 64/125 (51%), Gaps = 10/125 (8%)
Query: 26 KIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQ-ILEKQKRAR 84
KI E R + R Q + ++ ++ ++ + RE+ REQ+ + +Q+
Sbjct: 405 KIREQEEKRQEEEKIREQEK----RQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKI 460
Query: 85 LQYEKQMEERWRKLEEQRQREDQKRAAVEE--KRKQKLREEEERL---EAMMRRSLERTQ 139
+ EK EE R+ +E+ R+++K EE ++K+K+ E+EE++ E + R E+ +
Sbjct: 461 HEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIR 520
Query: 140 QLELK 144
+ E K
Sbjct: 521 EQEEK 525
Score = 33.1 bits (74), Expect = 0.94
Identities = 24/108 (22%), Positives = 54/108 (50%), Gaps = 11/108 (10%)
Query: 53 ERQRLAKERREEREKCLAAREQQIL-----EKQKRARLQYEKQMEERWRKLEEQRQREDQ 107
E L KE + K A E+ L ++Q+ + E++++E K++EQ ++ +
Sbjct: 266 EADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE 325
Query: 108 KRAAVEEKRKQKLREEE---ERLEAMMRRS---LERTQQLELKKKYSW 149
+ + E+ ++ R+EE E+ E M R+ E+ +++ +++ W
Sbjct: 326 QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMW 373
>gi|239752551 PREDICTED: hypothetical protein [Homo sapiens]
Length = 238
Score = 79.7 bits (195), Expect = 9e-15
Identities = 49/184 (26%), Positives = 109/184 (59%), Gaps = 17/184 (9%)
Query: 404 LAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEE 463
+ E+ R +K+ E+E + +E++++++ +E K + +EE++ E+E + QE+E K E+
Sbjct: 1 MREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKM-WEQEEKMQEQEEKMWEQ 59
Query: 464 EKKKQEGEEK----RKAGEEAKRKAEEELLLKEKQEQEKQEKA--MIEKQKEAAETKARE 517
E+K E EEK ++ E+ ++ E++ L+EK+E+ +++K +EK +E +T+ +
Sbjct: 60 EEKMWEQEEKMWEQQRLPEQKEKMWEQDERLREKEERMREQKMWQQVEKMREKKKTQEEK 119
Query: 518 VAEQ---------MRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKEDPKVG 568
+ EQ M E+E+ M + E++ E+++++ E ++ R+ + Q ++E +
Sbjct: 120 MQEQEEKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMR-D 178
Query: 569 VQPA 572
V+PA
Sbjct: 179 VEPA 182
Score = 71.2 bits (173), Expect = 3e-12
Identities = 54/199 (27%), Positives = 105/199 (52%), Gaps = 13/199 (6%)
Query: 419 EQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEK----- 473
E+ER+ + E+ E EE+ R+ EE+ EE+ R+QEE K E+E+K QE EEK
Sbjct: 3 EEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEE--KMWEQEEKMQEQEEKMWEQE 60
Query: 474 RKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQI 533
K E+ ++ E++ L ++K++ +Q++ + EK++ E K + E+MR E+++ +
Sbjct: 61 EKMWEQEEKMWEQQRLPEQKEKMWEQDERLREKEERMREQKMWQQVEKMR-EKKKTQEEK 119
Query: 534 EQERLERKKRIDEIMKRTRKSDVPPQVKKEDPKVGVQPAVCVEKKTKLVVPNKMEINGLN 593
QE+ E+ + +E+M + ++++++ K+ Q E++ K+ +
Sbjct: 120 MQEQEEKMQEQEEMMWEQEE-----KMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEE 174
Query: 594 TCQEVNGVDHAAPETYPQD 612
++V A E PQD
Sbjct: 175 KMRDVEPAGGEAGEGSPQD 193
Score = 58.5 bits (140), Expect = 2e-08
Identities = 54/207 (26%), Positives = 102/207 (49%), Gaps = 17/207 (8%)
Query: 331 KRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKP 390
+R E+EK +E E + +Q Q +E + +K ++ E + +
Sbjct: 5 ERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQ-----EQEEKMWEQ 59
Query: 391 TAGTTDAGEAAKILAEKRRQARLQKEQEEQERV-EKEEQDRLER-----EELKRKAEEER 444
+ E K+ ++R + +K E+ ER+ EKEE+ R ++ E+++ K + +
Sbjct: 60 EEKMWEQEE--KMWEQQRLPEQKEKMWEQDERLREKEERMREQKMWQQVEKMREKKKTQE 117
Query: 445 LRLEEEARK-QEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAM 503
+++E+ K QE+E E+E+K QE EEK EE R+ EE++ +E++ Q ++EK
Sbjct: 118 EKMQEQEEKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKM- 176
Query: 504 IEKQKEAAETKAREVAEQMRLEREQIM 530
+ E A +A E + Q ++IM
Sbjct: 177 --RDVEPAGGEAGEGSPQDNPTAQEIM 201
Score = 45.1 bits (105), Expect = 2e-04
Identities = 33/111 (29%), Positives = 59/111 (53%), Gaps = 16/111 (14%)
Query: 42 PQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQ 101
P+ E + DER R +ER E++ Q +EK + + E++M+E+ K++EQ
Sbjct: 77 PEQKEKMWEQDERLREKEERMREQKMW------QQVEKMREKKKTQEEKMQEQEEKMQEQ 130
Query: 102 RQ---REDQKRAAVEEK---RKQKLREEEERLEAMMRRSLERTQQLELKKK 146
+ +++K EEK +++K+RE+EE+ MR E+ Q E K +
Sbjct: 131 EEMMWEQEEKMQEQEEKMWEQEEKMREQEEK----MREQEEKMQGQEEKMR 177
Score = 44.3 bits (103), Expect = 4e-04
Identities = 27/102 (26%), Positives = 63/102 (61%), Gaps = 8/102 (7%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKR 109
+ +E R +E+ +E+E+ + +E+++ E++++ + Q EK M E+ K+ EQ ++ +++
Sbjct: 16 EEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEK-MWEQEEKMWEQEEKMWEQQ 74
Query: 110 AAVEEKRK-----QKLREEEERLEAMMRRSLERTQQLELKKK 146
E+K K ++LRE+EER+ ++ ++ +++ KKK
Sbjct: 75 RLPEQKEKMWEQDERLREKEERMRE--QKMWQQVEKMREKKK 114
Score = 43.1 bits (100), Expect = 0.001
Identities = 29/105 (27%), Positives = 54/105 (51%), Gaps = 18/105 (17%)
Query: 59 KERREEREKCLAAREQQILEKQKRARLQYEK--QMEERWRKLEEQRQREDQKRAAVEEK- 115
+ER EREK + E+ + E++++ + Q EK + EE+ + EE+ Q +++K EEK
Sbjct: 4 EERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKM 63
Query: 116 ---------------RKQKLREEEERLEAMMRRSLERTQQLELKK 145
+K+K+ E++ERL R E+ +++K
Sbjct: 64 WEQEEKMWEQQRLPEQKEKMWEQDERLREKEERMREQKMWQQVEK 108
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/124 (22%), Positives = 65/124 (52%), Gaps = 20/124 (16%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEK---------QMEERWR 96
E + +E+ R +E+ E+E+ + +E+++ E++++ Q EK Q E+ W
Sbjct: 26 EKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKMWE 85
Query: 97 KLE-----EQRQREDQKRAAVEEKR------KQKLREEEERLEAMMRRSLERTQQLELKK 145
+ E E+R RE + VE+ R ++K++E+EE+++ E+ ++++ ++
Sbjct: 86 QDERLREKEERMREQKMWQQVEKMREKKKTQEEKMQEQEEKMQEQEEMMWEQEEKMQEQE 145
Query: 146 KYSW 149
+ W
Sbjct: 146 EKMW 149
Score = 38.9 bits (89), Expect = 0.017
Identities = 30/137 (21%), Positives = 70/137 (51%), Gaps = 17/137 (12%)
Query: 43 QGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEER-WRKLEEQ 101
Q E + E + +E + ++ L +++++ E+ +R R + E+ E++ W+++E+
Sbjct: 50 QEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKMWEQDERLREKEERMREQKMWQQVEKM 109
Query: 102 RQR---EDQKRAAVEEK----------RKQKLREEEERL---EAMMRRSLERTQQLELKK 145
R++ +++K EEK +++K++E+EE++ E MR E+ ++ E K
Sbjct: 110 REKKKTQEEKMQEQEEKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKM 169
Query: 146 KYSWGAPLAIGPGGHDA 162
+ + P G +A
Sbjct: 170 QGQEEKMRDVEPAGGEA 186
Score = 37.7 bits (86), Expect = 0.038
Identities = 25/86 (29%), Positives = 52/86 (60%), Gaps = 5/86 (5%)
Query: 61 RREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKL 120
R EER + RE+++ E+++ R Q EK M+E+ K+ EQ ++ ++ ++E +++K+
Sbjct: 2 REEER---MREREKKMREEEEMMREQEEK-MQEQEEKMREQEEKMWEQEEKMQE-QEEKM 56
Query: 121 REEEERLEAMMRRSLERTQQLELKKK 146
E+EE++ + E+ + E K+K
Sbjct: 57 WEQEEKMWEQEEKMWEQQRLPEQKEK 82
Score = 33.5 bits (75), Expect = 0.72
Identities = 14/55 (25%), Positives = 35/55 (63%), Gaps = 4/55 (7%)
Query: 99 EEQRQREDQKRAAVEE----KRKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
EE+R RE +K+ EE ++++K++E+EE++ + E+ ++++ +++ W
Sbjct: 3 EEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMW 57
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 79.7 bits (195), Expect = 9e-15
Identities = 51/186 (27%), Positives = 116/186 (62%), Gaps = 13/186 (6%)
Query: 406 EKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEE-----ERKR 460
E++ Q + +K +E++E++ ++E+ E+EE R+ EE EE+ R+ EE E+ R
Sbjct: 301 EEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIR 360
Query: 461 QEEEKKKQE---GEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAR- 516
++EEK+++E E++++ +EAK +EE + +++++ +QE+ M E++++ E + +
Sbjct: 361 EQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKM 420
Query: 517 -EVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKEDPKVGVQPAVCV 575
E E+M+ E+E+ M + E++ E++K+I E ++ R+ + +++++ K+G Q
Sbjct: 421 WEQEEEMQ-EQEEKMRRQEEKIREQEKKIREQEEKIREQE--EMMQEQEEKMGEQEGKMC 477
Query: 576 EKKTKL 581
E++ K+
Sbjct: 478 EQEAKM 483
Score = 78.2 bits (191), Expect = 3e-14
Identities = 54/183 (29%), Positives = 107/183 (58%), Gaps = 12/183 (6%)
Query: 399 EAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEER 458
E KI ++ ++ +K +E+++R E+E ++ R+E K + +EE++R E+E QE+E
Sbjct: 355 EQEKIREQEEKRQEEEKIREQEKRQEQEA--KMWRQEEKIREQEEKIR-EQEEMMQEQEE 411
Query: 459 KRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREV 518
K E+E+K E EE+ + EE R+ EE++ +EK+ +E++EK I +Q+E + + ++
Sbjct: 412 KMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEK--IREQEEMMQEQEEKM 469
Query: 519 AEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKEDPKVGVQPAVCVEKK 578
EQ EQ EQE E+ +R +E ++ K ++++++ K+ Q + E++
Sbjct: 470 GEQEGKMCEQEAKMQEQE--EKMRRQEEKIREQEK-----KIREQEEKIREQEEMMQEQE 522
Query: 579 TKL 581
K+
Sbjct: 523 EKM 525
Score = 77.0 bits (188), Expect = 6e-14
Identities = 52/213 (24%), Positives = 117/213 (54%), Gaps = 11/213 (5%)
Query: 331 KRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKP 390
+ K ++E+ +E+E Q+A + EE + + EK E +G+
Sbjct: 363 EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ------EEKIREQEEMMQEQEEKMGEQ 416
Query: 391 TAGTTDAGEAAKILAEK-RRQARLQKEQEEQERVEKE---EQDRLEREELKRKAEEERLR 446
+ E + EK RRQ +EQE++ R ++E EQ+ + +E+ ++ E+E
Sbjct: 417 EEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKM 476
Query: 447 LEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEK 506
E+EA+ QE+E K + +E+K +E E+K + EE K + +EE++ +++++ +QE+ M E+
Sbjct: 477 CEQEAKMQEQEEKMRRQEEKIREQEKKIREQEE-KIREQEEMMQEQEEKMWEQEEKMCEQ 535
Query: 507 QKEAAETKAREVAEQMRLEREQIMLQIEQERLE 539
+++ E + + ++ ++ +++ L+ ++E+++
Sbjct: 536 EEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQ 568
Score = 76.6 bits (187), Expect = 7e-14
Identities = 50/183 (27%), Positives = 103/183 (56%), Gaps = 26/183 (14%)
Query: 399 EAAKILAEKRRQARL-------QKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEA 451
E KI +++RQ + +K +E++E++ ++E+ E+EE + EE+ EEE
Sbjct: 368 EEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEM 427
Query: 452 RKQEEERKRQEE-----EKKKQEGEEK------------RKAGEEAKRKAEEELLLKEKQ 494
++QEE+ +RQEE EKK +E EEK K GE+ + E+E ++E++
Sbjct: 428 QEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQE 487
Query: 495 EQEKQEKAMIEKQKEAAETKAREVAEQ--MRLEREQIMLQIEQERLERKKRIDEIMKRTR 552
E+ ++++ I +Q++ + ++ EQ M E+E+ M + E++ E+++++ E ++ R
Sbjct: 488 EKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMR 547
Query: 553 KSD 555
+ +
Sbjct: 548 RQE 550
Score = 74.7 bits (182), Expect = 3e-13
Identities = 52/192 (27%), Positives = 112/192 (58%), Gaps = 15/192 (7%)
Query: 402 KILAEKRRQARLQKEQ--EEQERVEK-----EEQDRLEREELKRKAE----EERLRLEEE 450
+++ EK + R Q+E E++E++ + EQ+++ +E KR+ E E+ R E+E
Sbjct: 323 EMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQE 382
Query: 451 ARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQK-E 509
A+ +E K +E+E+K +E EE + EE + EE++ +E++ QE++EK +++K
Sbjct: 383 AKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIR 442
Query: 510 AAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKEDPKVGV 569
E K RE E++R E+E++M + E++ E++ ++ E + + + ++++++ K+
Sbjct: 443 EQEKKIREQEEKIR-EQEEMMQEQEEKMGEQEGKMCE--QEAKMQEQEEKMRRQEEKIRE 499
Query: 570 QPAVCVEKKTKL 581
Q E++ K+
Sbjct: 500 QEKKIREQEEKI 511
Score = 72.4 bits (176), Expect = 1e-12
Identities = 43/158 (27%), Positives = 91/158 (57%), Gaps = 11/158 (6%)
Query: 402 KILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEER--- 458
K+ ++ + ++E +EQE + +++++ +E K + +EE++R +EE +++EE+
Sbjct: 412 KMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGE 471
Query: 459 ---KRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKA 515
K E+E K QE EEK + EE R E+E ++E++E+ ++++ M+++Q+E +
Sbjct: 472 QEGKMCEQEAKMQEQEEKMRRQEEKIR--EQEKKIREQEEKIREQEEMMQEQEEKMWEQE 529
Query: 516 REVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRK 553
++ EQ +EQ + + R E K R E+ R ++
Sbjct: 530 EKMCEQEEKMQEQ---EEKMRRQEEKMREQEVRLRQQE 564
Score = 70.9 bits (172), Expect = 4e-12
Identities = 73/293 (24%), Positives = 150/293 (51%), Gaps = 39/293 (13%)
Query: 323 ALSGQDMPKRKAEK--EKSNKEREG--------TLAQQAAGPQGEEALEK-HVVDKHASE 371
ALS K+KA++ E+ KER+ T+ + + + EK +V+ SE
Sbjct: 168 ALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSE 227
Query: 372 --KHAAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQE---RVEKE 426
+ K E + L +A K L A+LQ + EE E R+ ++
Sbjct: 228 IQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSV--SAKLQAQVEENELWNRLNQQ 285
Query: 427 EQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEE------EKKKQEGEEKRKAGEEA 480
+++++ R+E K + EE+++ +EE +++EE+ R++E E+K + EE EE
Sbjct: 286 QEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 345
Query: 481 KRKAEEELLLKEK---QEQEKQEKAMIEKQKEAAETKA---------REVAEQMRLEREQ 528
R+ EE++ +EK QE+++QE+ I +Q++ E +A RE E++R E+E+
Sbjct: 346 IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR-EQEE 404
Query: 529 IMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKEDPKVGVQPAVCVEKKTKL 581
+M + E++ E+++++ E + ++ + ++++++ K+ Q E++ K+
Sbjct: 405 MMQEQEEKMGEQEEKMWEQEEEMQEQE--EKMRRQEEKIREQEKKIREQEEKI 455
Score = 61.2 bits (147), Expect = 3e-09
Identities = 47/176 (26%), Positives = 87/176 (49%), Gaps = 13/176 (7%)
Query: 335 EKEKSNKEREGTLAQQAA--GPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTA 392
E+E+ +E+E + +Q G Q E+ E+ + EK E + +
Sbjct: 394 EQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEE 453
Query: 393 GTTDAGEAAKILAEK---------RRQARLQKEQEEQERVEKE--EQDRLEREELKRKAE 441
+ E + EK ++A++Q+++E+ R E++ EQ++ RE+ ++ E
Sbjct: 454 KIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIRE 513
Query: 442 EERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQE 497
+E + E+E + E+E K E+E+K QE EEK + EE R+ E L +E++ QE
Sbjct: 514 QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 50.1 bits (118), Expect = 7e-06
Identities = 32/100 (32%), Positives = 60/100 (60%), Gaps = 5/100 (5%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEK--QMEERWRKLEEQRQREDQ 107
+ +E+ +E+ +ERE+ + +E++I E++++ R Q E + EE+ R+ EE +++
Sbjct: 285 QQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 344
Query: 108 KRAAVEEK--RKQKLREEEE-RLEAMMRRSLERTQQLELK 144
K +EEK ++K+RE+EE R E R E+ Q+ E K
Sbjct: 345 KIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAK 384
Score = 49.3 bits (116), Expect = 1e-05
Identities = 36/111 (32%), Positives = 63/111 (56%), Gaps = 12/111 (10%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQME-ERWRKLEEQRQ- 103
E + +E+ R +E E+E+ + +E+ + EK+++ R EK E E+ R+ EE+RQ
Sbjct: 309 EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQE 368
Query: 104 ----REDQKRAAVEEK---RKQKLREEEERL---EAMMRRSLERTQQLELK 144
RE +KR E K +++K+RE+EE++ E MM+ E+ + E K
Sbjct: 369 EEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEK 419
Score = 49.3 bits (116), Expect = 1e-05
Identities = 32/110 (29%), Positives = 64/110 (58%), Gaps = 15/110 (13%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYE----------KQMEERWRKLE 99
+ +E + +E+R+E+E + +E++I E++++ R Q E +Q E+ W + E
Sbjct: 366 RQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEE 425
Query: 100 EQRQREDQKRAAVEEKRKQ--KLREEEERL---EAMMRRSLERTQQLELK 144
E +++E++ R E+ R+Q K+RE+EE++ E MM+ E+ + E K
Sbjct: 426 EMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGK 475
Score = 48.1 bits (113), Expect = 3e-05
Identities = 37/104 (35%), Positives = 62/104 (59%), Gaps = 10/104 (9%)
Query: 50 KSDERQRLAKERRE---EREKCLAAREQQILEKQKRARLQYEK--QMEERWRKLEEQRQR 104
K ER+ +E+ E E+E+ + +E+ + EK+++ R Q E + EE+ R+LEE +
Sbjct: 296 KIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE-KMH 354
Query: 105 EDQKRAAVEEKR--KQKLREEEER--LEAMMRRSLERTQQLELK 144
E +K EEKR ++K+RE+E+R EA M R E+ ++ E K
Sbjct: 355 EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 398
Score = 47.0 bits (110), Expect = 6e-05
Identities = 33/149 (22%), Positives = 74/149 (49%), Gaps = 12/149 (8%)
Query: 13 RPEGTARGTSLPGKIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAR 72
R E A+ KI E Q + E + +E+ +E +E+E+ + +
Sbjct: 378 RQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQ 437
Query: 73 EQQILEKQKRARLQYEK------QMEERWRKLEEQRQREDQKRAAVEE------KRKQKL 120
E++I E++K+ R Q EK M+E+ K+ EQ + ++ A ++E ++++K+
Sbjct: 438 EEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKI 497
Query: 121 REEEERLEAMMRRSLERTQQLELKKKYSW 149
RE+E+++ + E+ + ++ +++ W
Sbjct: 498 REQEKKIREQEEKIREQEEMMQEQEEKMW 526
Score = 46.2 bits (108), Expect = 1e-04
Identities = 28/102 (27%), Positives = 57/102 (55%), Gaps = 5/102 (4%)
Query: 45 MEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQ- 103
+E + E+ R +E+R+E EK REQ+ ++Q+ + E+++ E+ K+ EQ +
Sbjct: 349 LEEKMHEQEKIREQEEKRQEEEKI---REQEKRQEQEAKMWRQEEKIREQEEKIREQEEM 405
Query: 104 -REDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELK 144
+E +++ +E++ + EE + E MRR E+ ++ E K
Sbjct: 406 MQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKK 447
Score = 45.1 bits (105), Expect = 2e-04
Identities = 26/88 (29%), Positives = 55/88 (62%), Gaps = 8/88 (9%)
Query: 61 RREEREKCLAAREQQILEKQKRARLQYEK--QMEERWRKLEEQRQREDQKRAAVEEK--- 115
+ +E+E+ + +E++I E++K+ R Q EK + EE ++ EE+ +++K EEK
Sbjct: 482 KMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE 541
Query: 116 RKQKLREEEERL---EAMMRRSLERTQQ 140
+++K+R +EE++ E +R+ E+ Q+
Sbjct: 542 QEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 44.7 bits (104), Expect = 3e-04
Identities = 22/87 (25%), Positives = 51/87 (58%), Gaps = 2/87 (2%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKR 109
+ +E+ R +E+ E+EK + +E++I E+++ + Q EK E+ + E++ + ++Q+
Sbjct: 485 EQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEE 544
Query: 110 AAVEEKRKQKLREEEERLEAMMRRSLE 136
++++K+RE+E RL + E
Sbjct: 545 KM--RRQEEKMREQEVRLRQQEEKMQE 569
Score = 42.0 bits (97), Expect = 0.002
Identities = 24/109 (22%), Positives = 59/109 (54%), Gaps = 14/109 (12%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEK-------------QME 92
E + +E+ R +E+ E+EK + +E++I E+++ + Q EK +M+
Sbjct: 425 EEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQ 484
Query: 93 ERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQL 141
E+ K+ Q ++ ++ + E +++K+RE+EE ++ + E+ +++
Sbjct: 485 EQEEKMRRQEEKIREQEKKIRE-QEEKIREQEEMMQEQEEKMWEQEEKM 532
Score = 41.2 bits (95), Expect = 0.003
Identities = 26/97 (26%), Positives = 56/97 (57%), Gaps = 7/97 (7%)
Query: 53 ERQRLAKERREEREKCLAAREQQILEKQKRARLQYEK--QMEERWRKLEEQRQREDQKRA 110
E L +++E+ + +E++I E++++ + Q EK + EE+ R+ EE +++K
Sbjct: 274 EENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMR 333
Query: 111 AVEE---KRKQKLREEEERL--EAMMRRSLERTQQLE 142
EE ++++K+RE EE++ + +R E+ Q+ E
Sbjct: 334 RQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEE 370
Score = 41.2 bits (95), Expect = 0.003
Identities = 32/124 (25%), Positives = 67/124 (54%), Gaps = 17/124 (13%)
Query: 33 VRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQ------ 86
+R + R Q E + +E + +E+ E+E + +E ++ E++++ R Q
Sbjct: 441 IREQEKKIREQE-EKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIRE 499
Query: 87 YEKQMEERWRKLEEQR---QREDQKRAAVEEK---RKQKLREEEERLEAMMRRSLERTQQ 140
EK++ E+ K+ EQ Q +++K EEK +++K++E+EE+ MRR E+ ++
Sbjct: 500 QEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK----MRRQEEKMRE 555
Query: 141 LELK 144
E++
Sbjct: 556 QEVR 559
Score = 40.8 bits (94), Expect = 0.005
Identities = 26/105 (24%), Positives = 55/105 (52%), Gaps = 15/105 (14%)
Query: 60 ERREEREKCLAAREQQILE--------KQKRARLQYEKQMEERWRKLEEQRQ----REDQ 107
+R+ ER K L ++Q E + A+LQ + + E W +L +Q++ R+++
Sbjct: 236 KRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEE 295
Query: 108 KRAAVEEK---RKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
K EEK +++K+RE+EE++ E+ +++ +++ W
Sbjct: 296 KIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMW 340
Score = 39.3 bits (90), Expect = 0.013
Identities = 24/104 (23%), Positives = 58/104 (55%), Gaps = 9/104 (8%)
Query: 25 GKIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRAR 84
GK+ E A Q + E + +++ R +E+ E+E+ + +E+++ E++++
Sbjct: 474 GKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMC 533
Query: 85 LQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLE 128
Q EK E+ EE+ +R+++K +++ +LR++EE+++
Sbjct: 534 EQEEKMQEQ-----EEKMRRQEEKM----REQEVRLRQQEEKMQ 568
Score = 30.8 bits (68), Expect = 4.7
Identities = 28/100 (28%), Positives = 49/100 (49%), Gaps = 9/100 (9%)
Query: 53 ERQRLAKERREEREKCLAAREQQIL------EKQKRARLQYEK--QMEERWRKLEEQRQR 104
E L KE + K A E+ L +++++ Q EK + EE+ ++ EE+ +
Sbjct: 254 EADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIRE 313
Query: 105 EDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELK 144
+++K EE +K E+ R E MM E+ ++LE K
Sbjct: 314 QEEKMRRQEEMMWEK-EEKMRRQEEMMWEKEEKIRELEEK 352
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 79.3 bits (194), Expect = 1e-14
Identities = 51/187 (27%), Positives = 112/187 (59%), Gaps = 22/187 (11%)
Query: 402 KILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQ 461
KI ++ + R +++ EQE +E++D++ R+E K + +EE++R +EE ++EE+ R+
Sbjct: 319 KIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIRE 378
Query: 462 EEEK-------------KKQEGEEKRKA---GEEAKRKAEEELLLKEKQEQEKQEKAM-- 503
++EK K +E EEKR+ +E K + ++E + ++++E +QE+ +
Sbjct: 379 QDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRE 438
Query: 504 IEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKE 563
+E+ + E K REV E+M+ E E+ +Q ++E+++R++ ++I ++ K+ ++ K+
Sbjct: 439 LEEMMQDQEEKLREVEEKMQEEEEK--MQEQEEKIQRQE--EKIQEQEEKTWRQEKLLKQ 494
Query: 564 DPKVGVQ 570
+ K+ Q
Sbjct: 495 EEKIWEQ 501
Score = 74.7 bits (182), Expect = 3e-13
Identities = 55/169 (32%), Positives = 97/169 (57%), Gaps = 6/169 (3%)
Query: 406 EKRRQARLQKEQEE--QERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEE 463
E RQ +EQEE QE++ ++E+ E++E R+ EEE R EE+ R+ EE Q++
Sbjct: 389 EMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEE--MMQDQ 446
Query: 464 EKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMR 523
E+K +E EEK + EE ++ EE++ +E++ QE++EK +++ E K E E+M
Sbjct: 447 EEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMW 506
Query: 524 LEREQIMLQIE--QERLERKKRIDEIMKRTRKSDVPPQVKKEDPKVGVQ 570
+ E++ Q E QE+ E+ +R +E M+ + K ++ +V +Q
Sbjct: 507 RQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQ 555
Score = 70.1 bits (170), Expect = 7e-12
Identities = 45/165 (27%), Positives = 97/165 (58%), Gaps = 19/165 (11%)
Query: 406 EKRRQARL----QKEQEEQERVEKEEQDRLEREELKRKAEE------ERLR------LEE 449
E++RQ ++ +K +E+ E++ ++E++ +EE R+ EE E+LR EE
Sbjct: 401 EEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEE 460
Query: 450 EARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKE 509
E + QE+E K Q +E+K QE EE K + K +EE + +++++ +QE+ M E++++
Sbjct: 461 EEKMQEQEEKIQRQEEKIQEQEE--KTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEK 518
Query: 510 AAETKAREVAEQMRLEREQIMLQIEQERL-ERKKRIDEIMKRTRK 553
E + + ++ ++ +++ L ++E++ E++ R+ E+ +R K
Sbjct: 519 MQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGK 563
Score = 69.7 bits (169), Expect = 9e-12
Identities = 62/275 (22%), Positives = 139/275 (50%), Gaps = 28/275 (10%)
Query: 324 LSGQDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAEN 383
L+ Q K ++EK ++ E Q+ + EE + + H E+ E
Sbjct: 291 LNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIR------EQ 344
Query: 384 SAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEE 443
+ + + E + EK + +K +E+ E+++++E++ +EE R+ EE+
Sbjct: 345 EDKMWRQEEKIREQEEKIREQEEKMWRQE-EKIREQDEKIQEQEEEMWRQEEKIREQEEK 403
Query: 444 RL----RLEEEARKQEEERKRQEEEKKKQEG-----EEKRKAGEEAKRKAEEELLLKEKQ 494
R R E++ R+Q+E+ + QEEE +QE EE + EE R+ EE++ +E++
Sbjct: 404 RQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEK 463
Query: 495 EQEKQEKAMIEKQKEAAETKAREVAEQMRL--------EREQIMLQIEQERLERKKRIDE 546
QE++EK I++Q+E + + + Q +L E+E+ M + E++ E+++++ E
Sbjct: 464 MQEQEEK--IQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQE 521
Query: 547 IMKRTRKSDVPPQVKKEDPKVGVQPAVCVEKKTKL 581
++ ++ + ++++++ ++ Q E++ +L
Sbjct: 522 QEEKMQRQE--EKMREQEVRLWQQEEKMQEQEVRL 554
Score = 69.3 bits (168), Expect = 1e-11
Identities = 47/188 (25%), Positives = 109/188 (57%), Gaps = 21/188 (11%)
Query: 396 DAGEAAKILAEKRRQARLQKEQEEQERVEK---------EEQDRLEREELKRKAEEERLR 446
+ E +L +++ + ++E++ QE+ EK E+++++ R+E K +EE++R
Sbjct: 283 EENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIR 342
Query: 447 LEEEARKQEEERKRQEEEKKKQE------GEEKRKAGEEAKRKAEEELLLKE----KQEQ 496
+E+ ++EE+ R++EEK +++ EEK + +E ++ EEE+ +E +QE+
Sbjct: 343 EQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEE 402
Query: 497 EKQEKA-MIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSD 555
++QEK EK+ + K RE E+M + E+I ++E+ ++++++ E+ ++ ++ +
Sbjct: 403 KRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIR-ELEEMMQDQEEKLREVEEKMQEEE 461
Query: 556 VPPQVKKE 563
Q ++E
Sbjct: 462 EKMQEQEE 469
Score = 67.0 bits (162), Expect = 6e-11
Identities = 44/163 (26%), Positives = 97/163 (59%), Gaps = 16/163 (9%)
Query: 411 ARLQKEQEEQER---VEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKK 467
A+LQ + EE E + +++++++ R+E K + +EE++ E+E + +E+E K +E+K
Sbjct: 276 AKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKM-CEQELKIREQEEKMWRQEEKM 334
Query: 468 QEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLERE 527
E EEK + E+ + EE++ +E++ +E++EK + E K RE E+++ + E
Sbjct: 335 HEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQ------EEKIREQDEKIQEQEE 388
Query: 528 QIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKEDPKVGVQ 570
++ Q E+ R + +KR +++ ++ +K ++++D K+ Q
Sbjct: 389 EMWRQEEKIREQEEKRQEKMWRQEKK------MREQDEKIREQ 425
Score = 60.8 bits (146), Expect = 4e-09
Identities = 41/162 (25%), Positives = 87/162 (53%), Gaps = 22/162 (13%)
Query: 409 RQARLQKEQEEQERVEKEEQDRLERE----------------ELKRKAEEERLRLEEEAR 452
RQ + +EQ+E+ R ++EE R E + E++ K +EE +++E+
Sbjct: 410 RQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEE 469
Query: 453 K-QEEERKRQEEEKKKQEGEEKRKAGE-----EAKRKAEEELLLKEKQEQEKQEKAMIEK 506
K Q +E K QE+E+K E+ K E E K +EE + +++++ ++QE+ M +
Sbjct: 470 KIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQ 529
Query: 507 QKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIM 548
+++ E + R ++ +++ +++ LQ +ERL + + E++
Sbjct: 530 EEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELL 571
Score = 60.1 bits (144), Expect = 7e-09
Identities = 42/120 (35%), Positives = 71/120 (59%), Gaps = 9/120 (7%)
Query: 406 EKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEE-- 463
E++ Q +K QE++E+++++E+ E+EE K +E+ L+ EE+ +QEE+ RQEE
Sbjct: 454 EEKMQEEEEKMQEQEEKIQRQEEKIQEQEE-KTWRQEKLLKQEEKIWEQEEKMWRQEEKM 512
Query: 464 ---EKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAE 520
E+K QE EEK + EE R+ E L +QE++ QE+ + ++ E K + AE
Sbjct: 513 WEQEEKMQEQEEKMQRQEEKMREQEVRLW---QQEEKMQEQEVRLQELEERLGKLGQKAE 569
Score = 58.9 bits (141), Expect = 2e-08
Identities = 46/204 (22%), Positives = 105/204 (51%), Gaps = 22/204 (10%)
Query: 400 AAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERK 459
+AK+ A+ ++QE ++++++ +E K +E ++R +EE ++EE+
Sbjct: 275 SAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKM 334
Query: 460 RQEEEKKKQE------GEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAM---------- 503
++EEK +++ EEK + EE R+ EE++ +E++ +E+ EK
Sbjct: 335 HEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQE 394
Query: 504 --IEKQKEAAETKAREVAEQMRLEREQIMLQIEQ--ERLERKKRIDEIM--KRTRKSDVP 557
I +Q+E + K ++MR + E+I Q E+ + E+ + ++E+M + + +V
Sbjct: 395 EKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVE 454
Query: 558 PQVKKEDPKVGVQPAVCVEKKTKL 581
++++E+ K+ Q ++ K+
Sbjct: 455 EKMQEEEEKMQEQEEKIQRQEEKI 478
Score = 55.8 bits (133), Expect = 1e-07
Identities = 70/274 (25%), Positives = 128/274 (46%), Gaps = 24/274 (8%)
Query: 320 RLPALSGQDMPKRKAEKEKSNKE---REGTLAQQAAGPQGEEALEKH---VVDKHASEKH 373
RL ++ Q P+ +E + + R GT ++ + +LE + + D+ EK+
Sbjct: 161 RLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDAPSLELYRNTITDEELKEKN 220
Query: 374 AAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARL----QKEQEEQERVEKEEQD 429
A E L + ++ K L K +A+L Q+ Q E +R+ KE
Sbjct: 221 A-------ELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKE--- 270
Query: 430 RLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELL 489
L+ K +A+ E L +Q+EE+ ++EE K QE EEK E R+ EE++
Sbjct: 271 -LQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEE-KIQEQEEKMCEQELKIREQEEKMW 328
Query: 490 LKEKQEQEKQEKAMIEKQKE-AAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIM 548
+E++ E++EK ++ K E K RE E++R + E++ Q E+ R + +K ++
Sbjct: 329 RQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEE 388
Query: 549 KRTRKSD-VPPQVKKEDPKVGVQPAVCVEKKTKL 581
+ R+ + + Q +K K+ Q E+ K+
Sbjct: 389 EMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKI 422
Score = 53.5 bits (127), Expect = 7e-07
Identities = 38/139 (27%), Positives = 78/139 (56%), Gaps = 6/139 (4%)
Query: 406 EKRRQARLQKEQEEQERVEKEE-----QDRLEREELKRKAEEERLRLEEEARKQEEERKR 460
E++ Q + +K Q ++E+++++E Q++L ++E K +EE++ +EE ++EE+ +
Sbjct: 461 EEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQ 520
Query: 461 QEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAE 520
++EEK +++ EEK + E + EE++ +E + QE +E+ QK A +
Sbjct: 521 EQEEKMQRQ-EEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRESG 579
Query: 521 QMRLEREQIMLQIEQERLE 539
RL +LQ+E + E
Sbjct: 580 SQRLPTLTPILQVELKSQE 598
Score = 48.5 bits (114), Expect = 2e-05
Identities = 26/101 (25%), Positives = 63/101 (62%), Gaps = 6/101 (5%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQRE 105
E + +E+ +E+ E+++ + +E+++ ++++ R Q EK+ E+ WR+ ++ R+++
Sbjct: 360 EKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQD 419
Query: 106 DQKRAAVEE--KRKQKLREEEERLEAMMRRSLERTQQLELK 144
++ R EE ++++K+RE LE MM+ E+ +++E K
Sbjct: 420 EKIREQEEEMWRQEEKIRE----LEEMMQDQEEKLREVEEK 456
Score = 48.5 bits (114), Expect = 2e-05
Identities = 25/93 (26%), Positives = 60/93 (64%), Gaps = 6/93 (6%)
Query: 59 KERREEREKCLAAREQQILEKQKRARLQYEK--QMEERWRKLEEQRQREDQKRAAVEEKR 116
+E+ E+R++ + +E+++ E+ ++ R Q E+ + EE+ R+LEE Q +++K VEE
Sbjct: 398 REQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEE-- 455
Query: 117 KQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
K++EEEE+++ + + ++++ +++ +W
Sbjct: 456 --KMQEEEEKMQEQEEKIQRQEEKIQEQEEKTW 486
Score = 46.6 bits (109), Expect = 8e-05
Identities = 27/110 (24%), Positives = 61/110 (55%), Gaps = 2/110 (1%)
Query: 402 KILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQ 461
KI ++ + R +++ EQE +E++++++R+E K + +E RL +EE +++E R ++
Sbjct: 497 KIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQE 556
Query: 462 EEEKKKQEGEEKRKAGEEAKRKAEEEL--LLKEKQEQEKQEKAMIEKQKE 509
EE+ + G++ G + + L L Q + K ++A +Q++
Sbjct: 557 LEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQ 606
Score = 46.2 bits (108), Expect = 1e-04
Identities = 41/135 (30%), Positives = 71/135 (52%), Gaps = 17/135 (12%)
Query: 52 DERQRLAKERREEREKCLAAREQQILE------KQKRARLQYEK---QMEERWRKLEEQR 102
+E+ + +E+ +E+E+ + +E++I E +Q++ Q EK Q E+ WR+ EE+
Sbjct: 454 EEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQ-EEKM 512
Query: 103 QREDQKRAAVEEK---RKQKLREEEERL---EAMMRRSLERTQQLELK-KKYSWGAPLAI 155
+++K EEK +++K+RE+E RL E M+ R Q+LE + K A L
Sbjct: 513 WEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLG 572
Query: 156 GPGGHDACDKLSTST 170
G G +L T T
Sbjct: 573 GAGRESGSQRLPTLT 587
Score = 44.7 bits (104), Expect = 3e-04
Identities = 23/106 (21%), Positives = 62/106 (58%), Gaps = 2/106 (1%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEK--QMEERWRKLEEQRQ 103
E + +E+ +E+ E+E + +E++I E++++ R Q EK + EE+ R+ +E+ Q
Sbjct: 325 EKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQ 384
Query: 104 REDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
++++ EEK +++ + +E++ ++ E+ +++ +++ W
Sbjct: 385 EQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMW 430
Score = 43.9 bits (102), Expect = 5e-04
Identities = 25/102 (24%), Positives = 61/102 (59%), Gaps = 6/102 (5%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEK--QMEERWRKLEEQRQREDQ 107
+ +E+ +E+ +E+E+ + +E +I E++++ Q EK + EE+ R+ E++ R+++
Sbjct: 294 QQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEE 353
Query: 108 KRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
K EEK +RE+EE++ + E+ ++++ +++ W
Sbjct: 354 KIREQEEK----IREQEEKMWRQEEKIREQDEKIQEQEEEMW 391
Score = 41.6 bits (96), Expect = 0.003
Identities = 30/103 (29%), Positives = 60/103 (58%), Gaps = 9/103 (8%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQR---QRED 106
+ DE+ R +E +E+ + E+ + +++++ R + E++M+E K++EQ QR++
Sbjct: 417 EQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLR-EVEEKMQEEEEKMQEQEEKIQRQE 475
Query: 107 QKRAAVEEK--RKQKLREEEERL---EAMMRRSLERTQQLELK 144
+K EEK R++KL ++EE++ E M R E+ + E K
Sbjct: 476 EKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEK 518
Score = 40.8 bits (94), Expect = 0.005
Identities = 25/90 (27%), Positives = 56/90 (62%), Gaps = 3/90 (3%)
Query: 62 REEREKCLAAREQQILEKQKRARLQYEK--QMEERWRKLEEQRQREDQKRAAVEEKRKQK 119
RE+ EK + +E+++ E++++ R Q +K + EE+ R+ EE+ + +++K EEK +++
Sbjct: 321 REQEEK-MWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQ 379
Query: 120 LREEEERLEAMMRRSLERTQQLELKKKYSW 149
+ +E+ E M R+ + +Q E +++ W
Sbjct: 380 DEKIQEQEEEMWRQEEKIREQEEKRQEKMW 409
Score = 40.4 bits (93), Expect = 0.006
Identities = 25/105 (23%), Positives = 59/105 (56%), Gaps = 5/105 (4%)
Query: 45 MEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQR 104
++ ++ +E L +++EE+ + Q+ EK L+ +Q E+ WR+ E+ ++
Sbjct: 278 LQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQ 337
Query: 105 EDQKRAAVEE--KRKQKLREEEERL---EAMMRRSLERTQQLELK 144
E++ R ++ ++++K+RE+EE++ E M R E+ ++ + K
Sbjct: 338 EEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEK 382
Score = 35.8 bits (81), Expect = 0.15
Identities = 25/105 (23%), Positives = 54/105 (51%), Gaps = 15/105 (14%)
Query: 60 ERREEREKCLAAREQQILEKQK--------RARLQYEKQMEERWRKLEEQRQ----REDQ 107
+R+ ER + L ++Q +E + A+LQ + + E W L +Q++ R+++
Sbjct: 245 KRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEE 304
Query: 108 KRAAVEEK---RKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
K EEK ++ K+RE+EE++ + E+ +++ ++ W
Sbjct: 305 KIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMW 349
Score = 35.8 bits (81), Expect = 0.15
Identities = 19/81 (23%), Positives = 48/81 (59%), Gaps = 2/81 (2%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQRE 105
E + +++ R E+ E+E+ + +E++I E ++ + Q EK E + EE+ + +
Sbjct: 406 EKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQ 465
Query: 106 DQKRAAVEEKRKQKLREEEER 126
+Q+ +++++K++E+EE+
Sbjct: 466 EQEEKI--QRQEEKIQEQEEK 484
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 79.3 bits (194), Expect = 1e-14
Identities = 51/187 (27%), Positives = 112/187 (59%), Gaps = 22/187 (11%)
Query: 402 KILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQ 461
KI ++ + R +++ EQE +E++D++ R+E K + +EE++R +EE ++EE+ R+
Sbjct: 319 KIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIRE 378
Query: 462 EEEK-------------KKQEGEEKRKA---GEEAKRKAEEELLLKEKQEQEKQEKAM-- 503
++EK K +E EEKR+ +E K + ++E + ++++E +QE+ +
Sbjct: 379 QDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRE 438
Query: 504 IEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKE 563
+E+ + E K REV E+M+ E E+ +Q ++E+++R++ ++I ++ K+ ++ K+
Sbjct: 439 LEEMMQDQEEKLREVEEKMQEEEEK--MQEQEEKIQRQE--EKIQEQEEKTWRQEKLLKQ 494
Query: 564 DPKVGVQ 570
+ K+ Q
Sbjct: 495 EEKIWEQ 501
Score = 74.7 bits (182), Expect = 3e-13
Identities = 55/169 (32%), Positives = 97/169 (57%), Gaps = 6/169 (3%)
Query: 406 EKRRQARLQKEQEE--QERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEE 463
E RQ +EQEE QE++ ++E+ E++E R+ EEE R EE+ R+ EE Q++
Sbjct: 389 EMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEE--MMQDQ 446
Query: 464 EKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMR 523
E+K +E EEK + EE ++ EE++ +E++ QE++EK +++ E K E E+M
Sbjct: 447 EEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMW 506
Query: 524 LEREQIMLQIE--QERLERKKRIDEIMKRTRKSDVPPQVKKEDPKVGVQ 570
+ E++ Q E QE+ E+ +R +E M+ + K ++ +V +Q
Sbjct: 507 RQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQ 555
Score = 70.1 bits (170), Expect = 7e-12
Identities = 45/165 (27%), Positives = 97/165 (58%), Gaps = 19/165 (11%)
Query: 406 EKRRQARL----QKEQEEQERVEKEEQDRLEREELKRKAEE------ERLR------LEE 449
E++RQ ++ +K +E+ E++ ++E++ +EE R+ EE E+LR EE
Sbjct: 401 EEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEE 460
Query: 450 EARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKE 509
E + QE+E K Q +E+K QE EE K + K +EE + +++++ +QE+ M E++++
Sbjct: 461 EEKMQEQEEKIQRQEEKIQEQEE--KTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEK 518
Query: 510 AAETKAREVAEQMRLEREQIMLQIEQERL-ERKKRIDEIMKRTRK 553
E + + ++ ++ +++ L ++E++ E++ R+ E+ +R K
Sbjct: 519 MQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGK 563
Score = 69.7 bits (169), Expect = 9e-12
Identities = 62/275 (22%), Positives = 139/275 (50%), Gaps = 28/275 (10%)
Query: 324 LSGQDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAEN 383
L+ Q K ++EK ++ E Q+ + EE + + H E+ E
Sbjct: 291 LNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIR------EQ 344
Query: 384 SAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEE 443
+ + + E + EK + +K +E+ E+++++E++ +EE R+ EE+
Sbjct: 345 EDKMWRQEEKIREQEEKIREQEEKMWRQE-EKIREQDEKIQEQEEEMWRQEEKIREQEEK 403
Query: 444 RL----RLEEEARKQEEERKRQEEEKKKQEG-----EEKRKAGEEAKRKAEEELLLKEKQ 494
R R E++ R+Q+E+ + QEEE +QE EE + EE R+ EE++ +E++
Sbjct: 404 RQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEK 463
Query: 495 EQEKQEKAMIEKQKEAAETKAREVAEQMRL--------EREQIMLQIEQERLERKKRIDE 546
QE++EK I++Q+E + + + Q +L E+E+ M + E++ E+++++ E
Sbjct: 464 MQEQEEK--IQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQE 521
Query: 547 IMKRTRKSDVPPQVKKEDPKVGVQPAVCVEKKTKL 581
++ ++ + ++++++ ++ Q E++ +L
Sbjct: 522 QEEKMQRQE--EKMREQEVRLWQQEEKMQEQEVRL 554
Score = 69.3 bits (168), Expect = 1e-11
Identities = 47/188 (25%), Positives = 109/188 (57%), Gaps = 21/188 (11%)
Query: 396 DAGEAAKILAEKRRQARLQKEQEEQERVEK---------EEQDRLEREELKRKAEEERLR 446
+ E +L +++ + ++E++ QE+ EK E+++++ R+E K +EE++R
Sbjct: 283 EENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIR 342
Query: 447 LEEEARKQEEERKRQEEEKKKQE------GEEKRKAGEEAKRKAEEELLLKE----KQEQ 496
+E+ ++EE+ R++EEK +++ EEK + +E ++ EEE+ +E +QE+
Sbjct: 343 EQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEE 402
Query: 497 EKQEKA-MIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSD 555
++QEK EK+ + K RE E+M + E+I ++E+ ++++++ E+ ++ ++ +
Sbjct: 403 KRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIR-ELEEMMQDQEEKLREVEEKMQEEE 461
Query: 556 VPPQVKKE 563
Q ++E
Sbjct: 462 EKMQEQEE 469
Score = 67.0 bits (162), Expect = 6e-11
Identities = 44/163 (26%), Positives = 97/163 (59%), Gaps = 16/163 (9%)
Query: 411 ARLQKEQEEQER---VEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKK 467
A+LQ + EE E + +++++++ R+E K + +EE++ E+E + +E+E K +E+K
Sbjct: 276 AKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKM-CEQELKIREQEEKMWRQEEKM 334
Query: 468 QEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLERE 527
E EEK + E+ + EE++ +E++ +E++EK + E K RE E+++ + E
Sbjct: 335 HEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQ------EEKIREQDEKIQEQEE 388
Query: 528 QIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKEDPKVGVQ 570
++ Q E+ R + +KR +++ ++ +K ++++D K+ Q
Sbjct: 389 EMWRQEEKIREQEEKRQEKMWRQEKK------MREQDEKIREQ 425
Score = 60.8 bits (146), Expect = 4e-09
Identities = 41/162 (25%), Positives = 87/162 (53%), Gaps = 22/162 (13%)
Query: 409 RQARLQKEQEEQERVEKEEQDRLERE----------------ELKRKAEEERLRLEEEAR 452
RQ + +EQ+E+ R ++EE R E + E++ K +EE +++E+
Sbjct: 410 RQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEE 469
Query: 453 K-QEEERKRQEEEKKKQEGEEKRKAGE-----EAKRKAEEELLLKEKQEQEKQEKAMIEK 506
K Q +E K QE+E+K E+ K E E K +EE + +++++ ++QE+ M +
Sbjct: 470 KIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQ 529
Query: 507 QKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIM 548
+++ E + R ++ +++ +++ LQ +ERL + + E++
Sbjct: 530 EEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELL 571
Score = 60.1 bits (144), Expect = 7e-09
Identities = 42/120 (35%), Positives = 71/120 (59%), Gaps = 9/120 (7%)
Query: 406 EKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEE-- 463
E++ Q +K QE++E+++++E+ E+EE K +E+ L+ EE+ +QEE+ RQEE
Sbjct: 454 EEKMQEEEEKMQEQEEKIQRQEEKIQEQEE-KTWRQEKLLKQEEKIWEQEEKMWRQEEKM 512
Query: 464 ---EKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAE 520
E+K QE EEK + EE R+ E L +QE++ QE+ + ++ E K + AE
Sbjct: 513 WEQEEKMQEQEEKMQRQEEKMREQEVRLW---QQEEKMQEQEVRLQELEERLGKLGQKAE 569
Score = 58.9 bits (141), Expect = 2e-08
Identities = 46/204 (22%), Positives = 105/204 (51%), Gaps = 22/204 (10%)
Query: 400 AAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERK 459
+AK+ A+ ++QE ++++++ +E K +E ++R +EE ++EE+
Sbjct: 275 SAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKM 334
Query: 460 RQEEEKKKQE------GEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAM---------- 503
++EEK +++ EEK + EE R+ EE++ +E++ +E+ EK
Sbjct: 335 HEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQE 394
Query: 504 --IEKQKEAAETKAREVAEQMRLEREQIMLQIEQ--ERLERKKRIDEIM--KRTRKSDVP 557
I +Q+E + K ++MR + E+I Q E+ + E+ + ++E+M + + +V
Sbjct: 395 EKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVE 454
Query: 558 PQVKKEDPKVGVQPAVCVEKKTKL 581
++++E+ K+ Q ++ K+
Sbjct: 455 EKMQEEEEKMQEQEEKIQRQEEKI 478
Score = 55.1 bits (131), Expect = 2e-07
Identities = 70/274 (25%), Positives = 128/274 (46%), Gaps = 24/274 (8%)
Query: 320 RLPALSGQDMPKRKAEKEKSNKE---REGTLAQQAAGPQGEEALEKH---VVDKHASEKH 373
RL ++ Q P+ +E + + R GT ++ + +LE + + D+ EK+
Sbjct: 161 RLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDALSLELYRNTITDEELKEKN 220
Query: 374 AAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARL----QKEQEEQERVEKEEQD 429
A E L + ++ K L K +A+L Q+ Q E +R+ KE
Sbjct: 221 A-------ELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKE--- 270
Query: 430 RLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELL 489
L+ K +A+ E L +Q+EE+ ++EE K QE EEK E R+ EE++
Sbjct: 271 -LQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEE-KIQEQEEKMCEQELKIREQEEKMW 328
Query: 490 LKEKQEQEKQEKAMIEKQKE-AAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIM 548
+E++ E++EK ++ K E K RE E++R + E++ Q E+ R + +K ++
Sbjct: 329 RQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEE 388
Query: 549 KRTRKSD-VPPQVKKEDPKVGVQPAVCVEKKTKL 581
+ R+ + + Q +K K+ Q E+ K+
Sbjct: 389 EMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKI 422
Score = 53.5 bits (127), Expect = 7e-07
Identities = 38/139 (27%), Positives = 78/139 (56%), Gaps = 6/139 (4%)
Query: 406 EKRRQARLQKEQEEQERVEKEE-----QDRLEREELKRKAEEERLRLEEEARKQEEERKR 460
E++ Q + +K Q ++E+++++E Q++L ++E K +EE++ +EE ++EE+ +
Sbjct: 461 EEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQ 520
Query: 461 QEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAE 520
++EEK +++ EEK + E + EE++ +E + QE +E+ QK A +
Sbjct: 521 EQEEKMQRQ-EEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRESG 579
Query: 521 QMRLEREQIMLQIEQERLE 539
RL +LQ+E + E
Sbjct: 580 SQRLPTLTPILQVELKSQE 598
Score = 48.5 bits (114), Expect = 2e-05
Identities = 26/101 (25%), Positives = 63/101 (62%), Gaps = 6/101 (5%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQRE 105
E + +E+ +E+ E+++ + +E+++ ++++ R Q EK+ E+ WR+ ++ R+++
Sbjct: 360 EKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQD 419
Query: 106 DQKRAAVEE--KRKQKLREEEERLEAMMRRSLERTQQLELK 144
++ R EE ++++K+RE LE MM+ E+ +++E K
Sbjct: 420 EKIREQEEEMWRQEEKIRE----LEEMMQDQEEKLREVEEK 456
Score = 48.5 bits (114), Expect = 2e-05
Identities = 25/93 (26%), Positives = 60/93 (64%), Gaps = 6/93 (6%)
Query: 59 KERREEREKCLAAREQQILEKQKRARLQYEK--QMEERWRKLEEQRQREDQKRAAVEEKR 116
+E+ E+R++ + +E+++ E+ ++ R Q E+ + EE+ R+LEE Q +++K VEE
Sbjct: 398 REQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEE-- 455
Query: 117 KQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
K++EEEE+++ + + ++++ +++ +W
Sbjct: 456 --KMQEEEEKMQEQEEKIQRQEEKIQEQEEKTW 486
Score = 46.6 bits (109), Expect = 8e-05
Identities = 27/110 (24%), Positives = 61/110 (55%), Gaps = 2/110 (1%)
Query: 402 KILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQ 461
KI ++ + R +++ EQE +E++++++R+E K + +E RL +EE +++E R ++
Sbjct: 497 KIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQE 556
Query: 462 EEEKKKQEGEEKRKAGEEAKRKAEEEL--LLKEKQEQEKQEKAMIEKQKE 509
EE+ + G++ G + + L L Q + K ++A +Q++
Sbjct: 557 LEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQ 606
Score = 46.2 bits (108), Expect = 1e-04
Identities = 41/135 (30%), Positives = 71/135 (52%), Gaps = 17/135 (12%)
Query: 52 DERQRLAKERREEREKCLAAREQQILE------KQKRARLQYEK---QMEERWRKLEEQR 102
+E+ + +E+ +E+E+ + +E++I E +Q++ Q EK Q E+ WR+ EE+
Sbjct: 454 EEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQ-EEKM 512
Query: 103 QREDQKRAAVEEK---RKQKLREEEERL---EAMMRRSLERTQQLELK-KKYSWGAPLAI 155
+++K EEK +++K+RE+E RL E M+ R Q+LE + K A L
Sbjct: 513 WEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLG 572
Query: 156 GPGGHDACDKLSTST 170
G G +L T T
Sbjct: 573 GAGRESGSQRLPTLT 587
Score = 44.7 bits (104), Expect = 3e-04
Identities = 23/106 (21%), Positives = 62/106 (58%), Gaps = 2/106 (1%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEK--QMEERWRKLEEQRQ 103
E + +E+ +E+ E+E + +E++I E++++ R Q EK + EE+ R+ +E+ Q
Sbjct: 325 EKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQ 384
Query: 104 REDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
++++ EEK +++ + +E++ ++ E+ +++ +++ W
Sbjct: 385 EQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMW 430
Score = 43.9 bits (102), Expect = 5e-04
Identities = 25/102 (24%), Positives = 61/102 (59%), Gaps = 6/102 (5%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEK--QMEERWRKLEEQRQREDQ 107
+ +E+ +E+ +E+E+ + +E +I E++++ Q EK + EE+ R+ E++ R+++
Sbjct: 294 QQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEE 353
Query: 108 KRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
K EEK +RE+EE++ + E+ ++++ +++ W
Sbjct: 354 KIREQEEK----IREQEEKMWRQEEKIREQDEKIQEQEEEMW 391
Score = 41.6 bits (96), Expect = 0.003
Identities = 30/103 (29%), Positives = 60/103 (58%), Gaps = 9/103 (8%)
Query: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQR---QRED 106
+ DE+ R +E +E+ + E+ + +++++ R + E++M+E K++EQ QR++
Sbjct: 417 EQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLR-EVEEKMQEEEEKMQEQEEKIQRQE 475
Query: 107 QKRAAVEEK--RKQKLREEEERL---EAMMRRSLERTQQLELK 144
+K EEK R++KL ++EE++ E M R E+ + E K
Sbjct: 476 EKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEK 518
Score = 40.8 bits (94), Expect = 0.005
Identities = 25/90 (27%), Positives = 56/90 (62%), Gaps = 3/90 (3%)
Query: 62 REEREKCLAAREQQILEKQKRARLQYEK--QMEERWRKLEEQRQREDQKRAAVEEKRKQK 119
RE+ EK + +E+++ E++++ R Q +K + EE+ R+ EE+ + +++K EEK +++
Sbjct: 321 REQEEK-MWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQ 379
Query: 120 LREEEERLEAMMRRSLERTQQLELKKKYSW 149
+ +E+ E M R+ + +Q E +++ W
Sbjct: 380 DEKIQEQEEEMWRQEEKIREQEEKRQEKMW 409
Score = 40.4 bits (93), Expect = 0.006
Identities = 25/105 (23%), Positives = 59/105 (56%), Gaps = 5/105 (4%)
Query: 45 MEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQR 104
++ ++ +E L +++EE+ + Q+ EK L+ +Q E+ WR+ E+ ++
Sbjct: 278 LQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQ 337
Query: 105 EDQKRAAVEE--KRKQKLREEEERL---EAMMRRSLERTQQLELK 144
E++ R ++ ++++K+RE+EE++ E M R E+ ++ + K
Sbjct: 338 EEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEK 382
Score = 35.8 bits (81), Expect = 0.15
Identities = 25/105 (23%), Positives = 54/105 (51%), Gaps = 15/105 (14%)
Query: 60 ERREEREKCLAAREQQILEKQK--------RARLQYEKQMEERWRKLEEQRQ----REDQ 107
+R+ ER + L ++Q +E + A+LQ + + E W L +Q++ R+++
Sbjct: 245 KRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEE 304
Query: 108 KRAAVEEK---RKQKLREEEERLEAMMRRSLERTQQLELKKKYSW 149
K EEK ++ K+RE+EE++ + E+ +++ ++ W
Sbjct: 305 KIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMW 349
Score = 35.8 bits (81), Expect = 0.15
Identities = 19/81 (23%), Positives = 48/81 (59%), Gaps = 2/81 (2%)
Query: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQRE 105
E + +++ R E+ E+E+ + +E++I E ++ + Q EK E + EE+ + +
Sbjct: 406 EKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQ 465
Query: 106 DQKRAAVEEKRKQKLREEEER 126
+Q+ +++++K++E+EE+
Sbjct: 466 EQEEKI--QRQEEKIQEQEEK 484
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.126 0.342
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,180,139
Number of Sequences: 37866
Number of extensions: 1881625
Number of successful extensions: 89128
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1537
Number of HSP's successfully gapped in prelim test: 1426
Number of HSP's that attempted gapping in prelim test: 11991
Number of HSP's gapped (non-prelim): 27768
length of query: 732
length of database: 18,247,518
effective HSP length: 110
effective length of query: 622
effective length of database: 14,082,258
effective search space: 8759164476
effective search space used: 8759164476
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.