Guide to the Human Genome
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Search of human proteins with 227496440

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|227496440 multiple C2 domains, transmembrane 2 isoform 1
[Homo sapiens]
         (878 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|227496440 multiple C2 domains, transmembrane 2 isoform 1 [Hom...  1744   0.0  
gi|227496489 multiple C2 domains, transmembrane 2 isoform 2 [Hom...  1602   0.0  
gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Hom...   737   0.0  
gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo...   735   0.0  
gi|227496504 multiple C2 domains, transmembrane 2 isoform 3 [Hom...   573   e-163
gi|14149680 extended synaptotagmin-like protein 1 [Homo sapiens]      102   2e-21
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                    81   5e-15
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                    81   5e-15
gi|45387945 family with sequence similarity 62 (C2 domain contai...    80   1e-14
gi|103472031 family with sequence similarity 62 (C2 domain conta...    74   6e-13
gi|6005997 double C2-like domains, beta [Homo sapiens]                 70   1e-11
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                67   6e-11
gi|67763814 death-inducing-protein [Homo sapiens]                      67   6e-11
gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]             67   9e-11
gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens]              67   9e-11
gi|122937514 unc-13 homolog C [Homo sapiens]                           66   2e-10
gi|38570146 synaptotagmin VII [Homo sapiens]                           66   2e-10
gi|21361472 neural precursor cell expressed, developmentally dow...    65   3e-10
gi|222352086 neural precursor cell expressed, developmentally do...    65   3e-10
gi|222352090 neural precursor cell expressed, developmentally do...    65   4e-10
gi|222352088 neural precursor cell expressed, developmentally do...    65   4e-10
gi|122937247 unc-13 homolog A [Homo sapiens]                           64   5e-10
gi|47078261 double C2-like domains, alpha [Homo sapiens]               62   2e-09
gi|110611226 UNC13 (C. elegans)-like [Homo sapiens]                    62   2e-09
gi|45504376 synaptotagmin VI [Homo sapiens]                            62   3e-09
gi|114520609 neural precursor cell expressed, developmentally do...    60   7e-09
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]            59   2e-08
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]            59   2e-08
gi|13384594 protein kinase C, gamma [Homo sapiens]                     59   2e-08
gi|4506067 protein kinase C, alpha [Homo sapiens]                      58   3e-08

>gi|227496440 multiple C2 domains, transmembrane 2 isoform 1 [Homo
           sapiens]
          Length = 878

 Score = 1744 bits (4518), Expect = 0.0
 Identities = 878/878 (100%), Positives = 878/878 (100%)

Query: 1   MDLDKPSVWGSLKQRTRPLLINLSKKKVKKNPSKPPDLRARHHLDRRLSLSVPDLLEAEA 60
           MDLDKPSVWGSLKQRTRPLLINLSKKKVKKNPSKPPDLRARHHLDRRLSLSVPDLLEAEA
Sbjct: 1   MDLDKPSVWGSLKQRTRPLLINLSKKKVKKNPSKPPDLRARHHLDRRLSLSVPDLLEAEA 60

Query: 61  LAPEGRPYSGPQSSYTSVPSSLSTAGIFPKSSSSSLKQSEEELDWSQEEASHLHVVETDS 120
           LAPEGRPYSGPQSSYTSVPSSLSTAGIFPKSSSSSLKQSEEELDWSQEEASHLHVVETDS
Sbjct: 61  LAPEGRPYSGPQSSYTSVPSSLSTAGIFPKSSSSSLKQSEEELDWSQEEASHLHVVETDS 120

Query: 121 EEAYASPAERRRVSSNGIFDLQKTSLGGDAPEEPEKLCGSSDLNASMTSQHFEEQSVPGE 180
           EEAYASPAERRRVSSNGIFDLQKTSLGGDAPEEPEKLCGSSDLNASMTSQHFEEQSVPGE
Sbjct: 121 EEAYASPAERRRVSSNGIFDLQKTSLGGDAPEEPEKLCGSSDLNASMTSQHFEEQSVPGE 180

Query: 181 ASDGLSNLPSPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNP 240
           ASDGLSNLPSPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNP
Sbjct: 181 ASDGLSNLPSPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNP 240

Query: 241 VWDEIVVLPIQSLDQKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSL 300
           VWDEIVVLPIQSLDQKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSL
Sbjct: 241 VWDEIVVLPIQSLDQKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSL 300

Query: 301 EDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISI 360
           EDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISI
Sbjct: 301 EDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISI 360

Query: 361 TLLEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEV 420
           TLLEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEV
Sbjct: 361 TLLEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEV 420

Query: 421 WGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCV 480
           WGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCV
Sbjct: 421 WGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCV 480

Query: 481 CPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGN 540
           CPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGN
Sbjct: 481 CPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGN 540

Query: 541 DRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDG 600
           DRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDG
Sbjct: 541 DRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDG 600

Query: 601 QPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLSKKILSRD 660
           QPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLSKKILSRD
Sbjct: 601 QPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLSKKILSRD 660

Query: 661 VDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFAVFLITVWNFELYMIPLALLLIFVYN 720
           VDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFAVFLITVWNFELYMIPLALLLIFVYN
Sbjct: 661 VDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFAVFLITVWNFELYMIPLALLLIFVYN 720

Query: 721 FIRPVKGKVSSIQDSQESTDIDDEEDEDDKESEKKGLIERIYMVQDIVSTVQNVLEEIAS 780
           FIRPVKGKVSSIQDSQESTDIDDEEDEDDKESEKKGLIERIYMVQDIVSTVQNVLEEIAS
Sbjct: 721 FIRPVKGKVSSIQDSQESTDIDDEEDEDDKESEKKGLIERIYMVQDIVSTVQNVLEEIAS 780

Query: 781 FGERIKNTFNWTVPFLSSLACLILAAATIILYFIPLRYIILIWGINKFTKKLRNPYSIDN 840
           FGERIKNTFNWTVPFLSSLACLILAAATIILYFIPLRYIILIWGINKFTKKLRNPYSIDN
Sbjct: 781 FGERIKNTFNWTVPFLSSLACLILAAATIILYFIPLRYIILIWGINKFTKKLRNPYSIDN 840

Query: 841 NELLDFLSRVPSDVQKVQYAELKLCSSHSPLRKKRSAL 878
           NELLDFLSRVPSDVQKVQYAELKLCSSHSPLRKKRSAL
Sbjct: 841 NELLDFLSRVPSDVQKVQYAELKLCSSHSPLRKKRSAL 878


>gi|227496489 multiple C2 domains, transmembrane 2 isoform 2 [Homo
           sapiens]
          Length = 823

 Score = 1602 bits (4149), Expect = 0.0
 Identities = 820/878 (93%), Positives = 822/878 (93%), Gaps = 55/878 (6%)

Query: 1   MDLDKPSVWGSLKQRTRPLLINLSKKKVKKNPSKPPDLRARHHLDRRLSLSVPDLLEAEA 60
           MDLDKPSVWGSLKQRTRPLLINLSKKKVKKNPSKPPDLRARHHLDRRLSLSVPDLLEAEA
Sbjct: 1   MDLDKPSVWGSLKQRTRPLLINLSKKKVKKNPSKPPDLRARHHLDRRLSLSVPDLLEAEA 60

Query: 61  LAPEGRPYSGPQSSYTSVPSSLSTAGIFPKSSSSSLKQSEEELDWSQEEASHLHVVETDS 120
           LAPEGRPYSGPQSSYTSVPSSLSTAGIFPKSSSSSLKQSEEELDWSQEEASHLHVVETDS
Sbjct: 61  LAPEGRPYSGPQSSYTSVPSSLSTAGIFPKSSSSSLKQSEEELDWSQEEASHLHVVETDS 120

Query: 121 EEAYASPAERRRVSSNGIFDLQKTSLGGDAPEEPEKLCGSSDLNASMTSQHFEEQSVPGE 180
           EEAYASPAERRRVSSNGIFDLQKTSLGGDAPEEPEKLCGSSDLNASMTSQHFEEQSVPGE
Sbjct: 121 EEAYASPAERRRVSSNGIFDLQKTSLGGDAPEEPEKLCGSSDLNASMTSQHFEEQSVPGE 180

Query: 181 ASDGLSNLPSPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNP 240
           ASDGLSNLPSPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNP
Sbjct: 181 ASDGLSNLPSPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNP 240

Query: 241 VWDEIVVLPIQSLDQKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSL 300
           VWDEIVVLPIQSLDQKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSL
Sbjct: 241 VWDEIVVLPIQSLDQKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSL 300

Query: 301 EDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISI 360
           EDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISI
Sbjct: 301 EDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISI 360

Query: 361 TLLEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEV 420
           TLLEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEV
Sbjct: 361 TLLEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEV 420

Query: 421 WGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCV 480
           WGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCV
Sbjct: 421 WGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCV 480

Query: 481 CPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGN 540
           CPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGN
Sbjct: 481 CPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGN 540

Query: 541 DRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDG 600
           DRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDG
Sbjct: 541 DRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDG 600

Query: 601 QPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLSKKILSRD 660
           QPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLSKKILSRD
Sbjct: 601 QPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLSKKILSRD 660

Query: 661 VDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFAVFLITVWNFELYMIPLALLLIFVYN 720
           VDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFA                         
Sbjct: 661 VDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFA------------------------- 695

Query: 721 FIRPVKGKVSSIQDSQESTDIDDEEDEDDKESEKKGLIERIYMVQDIVSTVQNVLEEIAS 780
                                     E +K+    GLIERIYMVQDIVSTVQNVLEEIAS
Sbjct: 696 --------------------------ESEKK----GLIERIYMVQDIVSTVQNVLEEIAS 725

Query: 781 FGERIKNTFNWTVPFLSSLACLILAAATIILYFIPLRYIILIWGINKFTKKLRNPYSIDN 840
           FGERIKNTFNWTVPFLSSLACLILAAATIILYFIPLRYIILIWGINKFTKKLRNPYSIDN
Sbjct: 726 FGERIKNTFNWTVPFLSSLACLILAAATIILYFIPLRYIILIWGINKFTKKLRNPYSIDN 785

Query: 841 NELLDFLSRVPSDVQKVQYAELKLCSSHSPLRKKRSAL 878
           NELLDFLSRVPSDVQKVQYAELKLCSSHSPLRKKRSAL
Sbjct: 786 NELLDFLSRVPSDVQKVQYAELKLCSSHSPLRKKRSAL 823


>gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Homo
           sapiens]
          Length = 999

 Score =  737 bits (1903), Expect = 0.0
 Identities = 410/873 (46%), Positives = 553/873 (63%), Gaps = 72/873 (8%)

Query: 62  APEGRPYSGPQSSYTSVPSSLSTAGIFPKSSSSSLKQSEEELDWSQEEASHLHVVETDSE 121
           A  G P  G   S  S PSS S +     SS SS  Q     D +++E +         +
Sbjct: 142 AAGGTPPGG--RSPDSAPSSSSAS-----SSLSSSPQPPPRGDRARDEGAR-------RQ 187

Query: 122 EAYASPAERRRVSSNGIFDLQKTSLGGDAPEEPEKLCGSSDLNASMTSQ-HFEEQSVPGE 180
              A    ++  S  G   L++       P EP +    ++  A  T + H   Q +   
Sbjct: 188 GPGAHLCHQKSSSLPGTACLEQLLEPPPPPAEPAR--SPAESRAPETGEEHGSSQKIINT 245

Query: 181 ASDGLSNLP--SPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNL 238
           A    + +P   P  Y L I L+ G++L  RDR GTSDPYVKFK+ GK +++SK+I+KNL
Sbjct: 246 AGTSNAEVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNL 305

Query: 239 NPVWDEIVVLPIQSLDQKLRVKVYDRDL-TTSDFMGSAFVILSDLELNRTTEHILKLEDP 297
           NPVW+E   + +  L + L +KV+D D     DFMGSAF+ L+ LELNR T+  L L+DP
Sbjct: 306 NPVWEEKACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLKDP 365

Query: 298 NSLEDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRN---------------- 341
           +  + D+G+I+L++ L  K+G+ +      RK    S   L  N                
Sbjct: 366 HYPDHDLGIILLSVILTPKEGESRDVTMLMRKSWKRSSKELSENEVVGSYFSVKSLFWRT 425

Query: 342 ------------------------------LRLSESLKKNQLWNGIISITLLEGKNVSG- 370
                                         LRLS+  +K+ LW GI+SITL+EG+++   
Sbjct: 426 CGRPALPVLGFCRAELQNPYCKNVQFQTQSLRLSDLHRKSHLWRGIVSITLIEGRDLKAM 485

Query: 371 --GSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGKDNKKH 428
               +++ +V+ +LG Q+YKSK + K+ NPQW+EQFDFH + +R G++DI  W KD  K 
Sbjct: 486 DSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGVIDITAWDKDAGKR 545

Query: 429 EERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCVCPLADLSE 488
           ++ +G C+VD+SAL  +Q + LEL L+   G L++LVTLT  A VS+SDL V  L D  E
Sbjct: 546 DDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTASATVSISDLSVNSLEDQKE 605

Query: 489 RKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTV 548
           R++I +RY       ++KDVG LQVKV++A  L+AAD +GKSDPFC++EL NDRL THTV
Sbjct: 606 REEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTV 665

Query: 549 YKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVLK 608
           YKNLNPEWNKVFTF IKDIH VLEVTV+DED D+  DFLGKVAIPLLSI++G+   YVLK
Sbjct: 666 YKNLNPEWNKVFTFNIKDIHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQKAYVLK 725

Query: 609 NKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLSKKILSRDVDRVKRIT 668
           NK L    KGVIYLE+D+I+N VKAS+RT  P+E++++E+  +LSK++L R+  R+KR  
Sbjct: 726 NKQLTGPTKGVIYLEIDVIFNAVKASLRTLIPKEQKYIEEENRLSKQLLLRNFIRMKRCV 785

Query: 669 MAIWNTMQFLKSCFQWESTLRSTIAFAVFLITVWNFELYMIPLALLLIFVYNFIRPVKGK 728
           M + N   ++ SCF W+S  RS  AF +FL  VWNFELYMIPL LLL+  +N+   + GK
Sbjct: 786 MVLVNAAYYVNSCFDWDSPPRSLAAFVLFLFVVWNFELYMIPLVLLLLLTWNYFLIISGK 845

Query: 729 VSSIQDSQESTDIDDEE---DEDDKESEKKGLIERIYMVQDIVSTVQNVLEEIASFGERI 785
            +  +D+     ++DEE   D+DDK+SEKKG I +IY +Q++  +VQN+L+E+ASFGERI
Sbjct: 846 DNRQRDTVVEDMLEDEEEEDDKDDKDSEKKGFINKIYAIQEVCVSVQNILDEVASFGERI 905

Query: 786 KNTFNWTVPFLSSLACLILAAATIILYFIPLRYIILIWGINKFTKKLRNPYSIDNNELLD 845
           KNTFNWTVPFLS LA + L   T ILY IPLRYI+L+WGINKFTKKLR+PY+IDNNELLD
Sbjct: 906 KNTFNWTVPFLSWLAIVALCVFTAILYCIPLRYIVLVWGINKFTKKLRSPYAIDNNELLD 965

Query: 846 FLSRVPSDVQKVQYAELKLCSSHSPLRKKRSAL 878
           FLSRVPSDVQ VQY ELK   SHSP ++K++ L
Sbjct: 966 FLSRVPSDVQVVQYQELKPDPSHSPYKRKKNNL 998


>gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo
           sapiens]
          Length = 778

 Score =  735 bits (1898), Expect = 0.0
 Identities = 384/752 (51%), Positives = 510/752 (67%), Gaps = 57/752 (7%)

Query: 184 GLSNLPSPFA----YLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLN 239
           G SN   P A    Y L I L+ G++L  RDR GTSDPYVKFK+ GK +++SK+I+KNLN
Sbjct: 26  GTSNAEVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLN 85

Query: 240 PVWDEIVVLPIQSLDQKLRVKVYDRDL-TTSDFMGSAFVILSDLELNRTTEHILKLEDPN 298
           PVW+E   + +  L + L +KV+D D     DFMGSAF+ L+ LELNR T+  L L+DP+
Sbjct: 86  PVWEEKACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLKDPH 145

Query: 299 SLEDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRN----------------- 341
             + D+G+I+L++ L  K+G+ +      RK    S   L  N                 
Sbjct: 146 YPDHDLGIILLSVILTPKEGESRDVTMLMRKSWKRSSKELSENEVVGSYFSVKSLFWRTC 205

Query: 342 -----------------------------LRLSESLKKNQLWNGIISITLLEGKNVSG-- 370
                                        LRLS+  +K+ LW GI+SITL+EG+++    
Sbjct: 206 GRPALPVLGFCRAELQNPYCKNVQFQTQSLRLSDLHRKSHLWRGIVSITLIEGRDLKAMD 265

Query: 371 -GSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGKDNKKHE 429
              +++ +V+ +LG Q+YKSK + K+ NPQW+EQFDFH + +R G++DI  W KD  K +
Sbjct: 266 SNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGVIDITAWDKDAGKRD 325

Query: 430 ERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCVCPLADLSER 489
           + +G C+VD+SAL  +Q + LEL L+   G L++LVTLT  A VS+SDL V  L D  ER
Sbjct: 326 DFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTASATVSISDLSVNSLEDQKER 385

Query: 490 KQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVY 549
           ++I +RY       ++KDVG LQVKV++A  L+AAD +GKSDPFC++EL NDRL THTVY
Sbjct: 386 EEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVY 445

Query: 550 KNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVLKN 609
           KNLNPEWNKVFTF IKDIH VLEVTV+DED D+  DFLGKVAIPLLSI++G+   YVLKN
Sbjct: 446 KNLNPEWNKVFTFNIKDIHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQKAYVLKN 505

Query: 610 KDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLSKKILSRDVDRVKRITM 669
           K L    KGVIYLE+D+I+N VKAS+RT  P+E++++E+  +LSK++L R+  R+KR  M
Sbjct: 506 KQLTGPTKGVIYLEIDVIFNAVKASLRTLIPKEQKYIEEENRLSKQLLLRNFIRMKRCVM 565

Query: 670 AIWNTMQFLKSCFQWESTLRSTIAFAVFLITVWNFELYMIPLALLLIFVYNFIRPVKGKV 729
            + N   ++ SCF W+S  RS  AF +FL  VWNFELYMIPL LLL+  +N+   + GK 
Sbjct: 566 VLVNAAYYVNSCFDWDSPPRSLAAFVLFLFVVWNFELYMIPLVLLLLLTWNYFLIISGKD 625

Query: 730 SSIQDSQESTDIDDEE---DEDDKESEKKGLIERIYMVQDIVSTVQNVLEEIASFGERIK 786
           +  +D+     ++DEE   D+DDK+SEKKG I +IY +Q++  +VQN+L+E+ASFGERIK
Sbjct: 626 NRQRDTVVEDMLEDEEEEDDKDDKDSEKKGFINKIYAIQEVCVSVQNILDEVASFGERIK 685

Query: 787 NTFNWTVPFLSSLACLILAAATIILYFIPLRYIILIWGINKFTKKLRNPYSIDNNELLDF 846
           NTFNWTVPFLS LA + L   T ILY IPLRYI+L+WGINKFTKKLR+PY+IDNNELLDF
Sbjct: 686 NTFNWTVPFLSWLAIVALCVFTAILYCIPLRYIVLVWGINKFTKKLRSPYAIDNNELLDF 745

Query: 847 LSRVPSDVQKVQYAELKLCSSHSPLRKKRSAL 878
           LSRVPSDVQ VQY ELK   SHSP ++K++ L
Sbjct: 746 LSRVPSDVQVVQYQELKPDPSHSPYKRKKNNL 777



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 45/189 (23%), Positives = 80/189 (42%), Gaps = 7/189 (3%)

Query: 490 KQITQRYCLQNSLKDVKDVGILQVKVL--KAADLLAADFSGKSDPFCLLELGNDRL-QTH 546
           K+I       N+   + D G+ Q+ +   +   L A D  G SDP+   ++G   + ++ 
Sbjct: 19  KKIINTAGTSNAEVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSK 78

Query: 547 TVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYV 606
            ++KNLNP W +     +  + + L + VFD D     DF+G   + L  +   +P    
Sbjct: 79  IIHKNLNPVWEEKACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVT 138

Query: 607 LKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTP-REKRFVEDSRKLSKKILSRDVDRVK 665
           L  KD       +  + + +I  P +   R  T    K +   S++LS+  +      VK
Sbjct: 139 LTLKDPHYPDHDLGIILLSVILTPKEGESRDVTMLMRKSWKRSSKELSENEVVGSYFSVK 198

Query: 666 RITMAIWNT 674
            +    W T
Sbjct: 199 SL---FWRT 204


>gi|227496504 multiple C2 domains, transmembrane 2 isoform 3 [Homo
           sapiens]
          Length = 306

 Score =  573 bits (1476), Expect = e-163
 Identities = 283/283 (100%), Positives = 283/283 (100%)

Query: 413 MGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAG 472
           MGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAG
Sbjct: 1   MGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAG 60

Query: 473 VSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDP 532
           VSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDP
Sbjct: 61  VSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDP 120

Query: 533 FCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAI 592
           FCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAI
Sbjct: 121 FCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAI 180

Query: 593 PLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKL 652
           PLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKL
Sbjct: 181 PLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKL 240

Query: 653 SKKILSRDVDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFA 695
           SKKILSRDVDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFA
Sbjct: 241 SKKILSRDVDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFA 283



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 6/122 (4%)

Query: 195 LLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVLPIQSLD 254
           +L + + +  +L+  D  G SDP+   +L    L ++  +YKNLNP W+++   PI+ + 
Sbjct: 98  ILQVKVLKAADLLAADFSGKSDPFCLLELGNDRL-QTHTVYKNLNPEWNKVFTFPIKDIH 156

Query: 255 QKLRVKVYDRD-LTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLEDDM-GVIVLNLN 312
             L V V+D D     DF+G   + L  +   +   ++LK +D   LE    GVI L ++
Sbjct: 157 DVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVLKNKD---LEQAFKGVIYLEMD 213

Query: 313 LV 314
           L+
Sbjct: 214 LI 215



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 26/100 (26%), Positives = 52/100 (52%), Gaps = 4/100 (4%)

Query: 356 GIISITLLEGKNVSGGSMT---EMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDR 412
           GI+ + +L+  ++     +   + F  L+LG+ R ++ T+ K+ NP+W + F F    D 
Sbjct: 97  GILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFP-IKDI 155

Query: 413 MGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLEL 452
             +L++ V+ +D  K  + LG   + + ++   Q NC  L
Sbjct: 156 HDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVL 195


>gi|14149680 extended synaptotagmin-like protein 1 [Homo sapiens]
          Length = 1104

 Score =  102 bits (254), Expect = 2e-21
 Identities = 118/443 (26%), Positives = 191/443 (43%), Gaps = 71/443 (16%)

Query: 195 LLTIHLKEGRNLVVRDRC------GTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVL 248
           ++ IHL   R L  +D+       G SDPY   +L  +T + S+VI + LNP W E   +
Sbjct: 330 IIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQT-FCSRVIDEELNPQWGETYEV 388

Query: 249 PIQSLD-QKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLEDDMGVI 307
            +  +  Q++ V+V+D+D    DF+G        L++ +  +  + L+D   L+   G +
Sbjct: 389 MVHEVPGQEIEVEVFDKDPDKDDFLGRM-----KLDVGKVLQASV-LDDWFPLQGGQGQV 442

Query: 308 VLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGKN 367
            L L  +    D             A K   +       S + +     I+ + L   ++
Sbjct: 443 HLRLEWLSLLSD-------------AEKLEQVLQWNWGVSSRPDPPSAAILVVYLDRAQD 489

Query: 368 V---SGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGKD 424
           +    G       VQL + D   +SK +  +  P W+E F F     +   LD++V  KD
Sbjct: 490 LPLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQELDVQV--KD 547

Query: 425 NKKHEERLGTCKVDISALPLKQANCL---ELPLDSCL-------GALLMLVTLTPCAGVS 474
           + +         + + AL L  A  L   EL LD           + L +  +     + 
Sbjct: 548 DSR--------ALTLGALTLPLARLLTAPELILDQWFQLSSSGPNSRLYMKLVMRILYLD 599

Query: 475 VSDLCV-----CPLA-DL-SERKQ------ITQRYCLQNSLKDVKDVGILQVKVLKAADL 521
            S++C      CP A D+ SE  Q         R C            +L++ VL+A DL
Sbjct: 600 SSEICFPTVPGCPGAWDVDSENPQRGSSVDAPPRPCHTTPDSQFGTEHVLRIHVLEAQDL 659

Query: 522 LAAD------FSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDI-HDVLEVT 574
           +A D        GKSDP+  L+L     ++H V ++LNP WN+VF   +  +    LEV 
Sbjct: 660 IAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVIVTSVPGQELEVE 719

Query: 575 VFDEDGDKPPDFLGKVAIPLLSI 597
           VFD+D DK  DFLG+  + L ++
Sbjct: 720 VFDKDLDK-DDFLGRCKVRLTTV 741



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 76/286 (26%), Positives = 139/286 (48%), Gaps = 34/286 (11%)

Query: 194 YLLTIHLKEGRNLVVRDRC------GTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVV 247
           ++L IH+ E ++L+ +DR       G SDPYVK KL G++ ++S V+ ++LNP W+E+  
Sbjct: 647 HVLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRS-FRSHVVREDLNPRWNEVFE 705

Query: 248 LPIQSLD-QKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLEDDMGV 306
           + + S+  Q+L V+V+D+DL   DF+G   V L+ +  +   +  L LED  S     G 
Sbjct: 706 VIVTSVPGQELEVEVFDKDLDKDDFLGRCKVRLTTVLNSGFLDEWLTLEDVPS-----GR 760

Query: 307 IVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGK 366
           + L L  +              +  +A    +++   L ++ K  +L   ++SI +   +
Sbjct: 761 LHLRLERLTP------------RPTAAELEEVLQVNSLIQTQKSAELAAALLSIYMERAE 808

Query: 367 NV---SGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGK 423
           ++    G      +  L +GD  +K+KT+ +++ P W E   F         L+++V G+
Sbjct: 809 DLPLRKGTKHLSPYATLTVGDSSHKTKTISQTSAPVWDESASFLIRKPHTESLELQVRGE 868

Query: 424 DNKKHEERLGTCKVDISALPLKQANCLE--LPLDSCLGALLMLVTL 467
                   LG+  + +S L +    CL+    L S  G +L+   L
Sbjct: 869 GTGV----LGSLSLPLSELLVADQLCLDRWFTLSSGQGQVLLRAQL 910



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 30/91 (32%), Positives = 51/91 (56%), Gaps = 8/91 (8%)

Query: 509 GILQVKVLKAADLLAAD------FSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTF 562
           GI+++ +L A  L + D        GKSDP+ L+ LG     +  + + LNP+W + +  
Sbjct: 329 GIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFCSRVIDEELNPQWGETYEV 388

Query: 563 PIKDI-HDVLEVTVFDEDGDKPPDFLGKVAI 592
            + ++    +EV VFD+D DK  DFLG++ +
Sbjct: 389 MVHEVPGQEIEVEVFDKDPDK-DDFLGRMKL 418



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 62/257 (24%), Positives = 111/257 (43%), Gaps = 30/257 (11%)

Query: 350 KNQLWNGIISITLLEGKNVSGGSM---------TEMFVQLKLGDQRYKSKTLCKSANPQW 400
           ++ L  GII I LL  + +S             ++ +  ++LG Q + S+ + +  NPQW
Sbjct: 323 RSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFCSRVIDEELNPQW 382

Query: 401 QEQFDFHYFSDRMGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLE--LPLDSCL 458
            E ++          +++EV+ KD  K ++ LG  K+D+  +   QA+ L+   PL    
Sbjct: 383 GETYEVMVHEVPGQEIEVEVFDKDPDK-DDFLGRMKLDVGKV--LQASVLDDWFPLQGGQ 439

Query: 459 GALLMLVTLTPCAGVSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKA 518
           G + + +                 L+D  + +Q+ Q     +S  D     IL V + +A
Sbjct: 440 GQVHLRLEWLSL------------LSDAEKLEQVLQWNWGVSSRPDPPSAAILVVYLDRA 487

Query: 519 ADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIH-DVLEVTVFD 577
            DL     + + +P   L + +   ++  VY    P W + F F ++D     L+V V D
Sbjct: 488 QDLPLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQELDVQVKD 547

Query: 578 EDGDKPPDFLGKVAIPL 594
              D     LG + +PL
Sbjct: 548 ---DSRALTLGALTLPL 561


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 45/116 (38%), Positives = 68/116 (58%), Gaps = 3/116 (2%)

Query: 487  SERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTH 546
            +E+K+  + Y  Q   +    +G L V V++A +L A   +GKS+P+C + +G+    T 
Sbjct: 1522 TEKKKREKAY--QARSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTR 1579

Query: 547  TVYKNLNPEWNKVFTFPIKDIH-DVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQ 601
            T+   LNP+WN    F IKD++ DVL +T+FD D   P DFLG+  IP+  IR  Q
Sbjct: 1580 TIQDTLNPKWNFNCQFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQ 1635



 Score = 33.5 bits (75), Expect = 0.89
 Identities = 18/90 (20%), Positives = 43/90 (47%), Gaps = 2/90 (2%)

Query: 357  IISITLLEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGIL 416
            +I  T L+    +G S    + ++ +G Q Y ++T+  + NP+W     F        +L
Sbjct: 1548 VIEATELKACKPNGKS--NPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDLYQDVL 1605

Query: 417  DIEVWGKDNKKHEERLGTCKVDISALPLKQ 446
             + ++ +D    ++ LG  ++ ++ +  +Q
Sbjct: 1606 CLTLFDRDQFSPDDFLGRTEIPVAKIRTEQ 1635


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 45/116 (38%), Positives = 68/116 (58%), Gaps = 3/116 (2%)

Query: 487  SERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTH 546
            +E+K+  + Y  Q   +    +G L V V++A +L A   +GKS+P+C + +G+    T 
Sbjct: 1549 TEKKKREKAY--QARSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTR 1606

Query: 547  TVYKNLNPEWNKVFTFPIKDIH-DVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQ 601
            T+   LNP+WN    F IKD++ DVL +T+FD D   P DFLG+  IP+  IR  Q
Sbjct: 1607 TIQDTLNPKWNFNCQFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQ 1662



 Score = 33.5 bits (75), Expect = 0.89
 Identities = 18/90 (20%), Positives = 43/90 (47%), Gaps = 2/90 (2%)

Query: 357  IISITLLEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGIL 416
            +I  T L+    +G S    + ++ +G Q Y ++T+  + NP+W     F        +L
Sbjct: 1575 VIEATELKACKPNGKS--NPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDLYQDVL 1632

Query: 417  DIEVWGKDNKKHEERLGTCKVDISALPLKQ 446
             + ++ +D    ++ LG  ++ ++ +  +Q
Sbjct: 1633 CLTLFDRDQFSPDDFLGRTEIPVAKIRTEQ 1662


>gi|45387945 family with sequence similarity 62 (C2 domain
           containing) member B [Homo sapiens]
          Length = 893

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 63/259 (24%), Positives = 121/259 (46%), Gaps = 32/259 (12%)

Query: 195 LLTIHLKEGRNLVVRDRC------GTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIV-V 247
           +L IH  E ++L  +D        G SDPY   ++ G  +++S+VI +NL+P W+E+   
Sbjct: 358 VLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRV-GNQIFQSRVIKENLSPKWNEVYEA 416

Query: 248 LPIQSLDQKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLEDDMGVI 307
           L  +   Q+L ++++D D    DF+GS  + L ++E  R  +    L++           
Sbjct: 417 LVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDE----------- 465

Query: 308 VLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGKN 367
                 V K     R  W      +++   ++ +++  +    + L + ++ + L   +N
Sbjct: 466 ------VPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARN 519

Query: 368 VSGG----SMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGK 423
           +  G    S     VQ+ +G +  +SK   K+  P W+E F F   + +   L++EV   
Sbjct: 520 LPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEV--- 576

Query: 424 DNKKHEERLGTCKVDISAL 442
            +++H+  LG  KV +S L
Sbjct: 577 RDEQHQCSLGNLKVPLSQL 595



 Score = 63.5 bits (153), Expect = 8e-10
 Identities = 34/96 (35%), Positives = 56/96 (58%), Gaps = 8/96 (8%)

Query: 509 GILQVKVLKAADLLAAD------FSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVF-T 561
           G+L++  ++A DL   D        GKSDP+ ++ +GN   Q+  + +NL+P+WN+V+  
Sbjct: 357 GVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEA 416

Query: 562 FPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSI 597
              +     LE+ +FDED DK  DFLG + I L+ +
Sbjct: 417 LVYEHPGQELEIELFDEDPDK-DDFLGSLMIDLIEV 451



 Score = 30.4 bits (67), Expect = 7.5
 Identities = 29/94 (30%), Positives = 42/94 (44%), Gaps = 10/94 (10%)

Query: 513 VKVLKAADLLAADFSGKSDPFCLLELGND-----RLQTHTVYKNLNPEWNKVFTFPI--- 564
           + V+ A   L A     SDP+  + L  D     R +TH   K LNP +++ F F +   
Sbjct: 776 IVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLP 835

Query: 565 KDIHDVLEVTVFDEDG--DKPPDFLGKVAIPLLS 596
           +     L+V V +  G   K    LGKV + L S
Sbjct: 836 EVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALAS 869


>gi|103472031 family with sequence similarity 62 (C2 domain
           containing), member C [Homo sapiens]
          Length = 886

 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 74/282 (26%), Positives = 120/282 (42%), Gaps = 30/282 (10%)

Query: 176 SVPGEASDGLSNLPSPFAY-LLTIHLKEGRNLVVRDRC----GTSDPYVKFKLNGKTLYK 230
           +VP +    L+NL  P    ++ +HL E   L  +D      G SDPY K  + G   ++
Sbjct: 287 TVPVKKGLDLTNLRFPLPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSI-GLQHFR 345

Query: 231 SKVIYKNLNPVWDEIVVLPIQSLD-QKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTE 289
           S+ IY+NLNP W+E+    +  +  Q L V +YD D    DF+GS  + L D+  NR  +
Sbjct: 346 SRTIYRNLNPTWNEVFEFMVYEVPGQDLEVDLYDEDTDRDDFLGSLQICLGDVMTNRVVD 405

Query: 290 HILKLEDPNSLEDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLK 349
               L D  S     G + L L  +    D              S + L+  L  + +L 
Sbjct: 406 EWFVLNDTTS-----GRLHLRLEWLSLLTD---QEVLTEDHGGLSTAILVVFLESACNLP 457

Query: 350 KN--QLWNG---IISITLLEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQF 404
           +N     NG      ++      VS    +  +V+L +G + + SKT   + +P W + F
Sbjct: 458 RNPFDYLNGEYRAKKLSRFARNKVSKDPSS--YVKLSVGKKTHTSKTCPHNKDPVWSQVF 515

Query: 405 DFHYFSDRMGILDIEVWGKDNKKHEERLGTCKVDISALPLKQ 446
            F   +     L ++V   D +        C + +  +PL Q
Sbjct: 516 SFFVHNVATERLHLKVLDDDQE--------CALGMLEVPLCQ 549



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 36/91 (39%), Positives = 56/91 (61%), Gaps = 6/91 (6%)

Query: 509 GILQVKVLKAADLLAAD----FSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPI 564
           G+++V +L+A  L   D      GKSDP+  + +G    ++ T+Y+NLNP WN+VF F +
Sbjct: 306 GVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQHFRSRTIYRNLNPTWNEVFEFMV 365

Query: 565 KDI-HDVLEVTVFDEDGDKPPDFLGKVAIPL 594
            ++    LEV ++DED D+  DFLG + I L
Sbjct: 366 YEVPGQDLEVDLYDEDTDR-DDFLGSLQICL 395



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 60/301 (19%), Positives = 126/301 (41%), Gaps = 31/301 (10%)

Query: 327 NRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGKNVSGGS-------MTEMFVQ 379
           NR  +   K   + NLR         L  G+I + LLE + ++           ++ + +
Sbjct: 284 NRVTVPVKKGLDLTNLRFP-------LPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAK 336

Query: 380 LKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGKDNKKHEERLGTCKVDI 439
           + +G Q ++S+T+ ++ NP W E F+F  +      L+++++ +D  + ++ LG+ ++ +
Sbjct: 337 VSIGLQHFRSRTIYRNLNPTWNEVFEFMVYEVPGQDLEVDLYDEDTDR-DDFLGSLQICL 395

Query: 440 SALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCVCPLADLSERKQITQRYCLQ 499
             +   +       L+      L L  L   + ++  ++       LS    +       
Sbjct: 396 GDVMTNRVVDEWFVLNDTTSGRLHL-RLEWLSLLTDQEVLTEDHGGLSTAILVVFLESAC 454

Query: 500 NSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKV 559
           N  ++  D    + +  K +       S     +  L +G     + T   N +P W++V
Sbjct: 455 NLPRNPFDYLNGEYRAKKLSRFARNKVSKDPSSYVKLSVGKKTHTSKTCPHNKDPVWSQV 514

Query: 560 FTFPIKDI-HDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVLKNKD--LEQAF 616
           F+F + ++  + L + V D+D +     LG + +PL         C +L   D  LEQ F
Sbjct: 515 FSFFVHNVATERLHLKVLDDDQECA---LGMLEVPL---------CQILPYADLTLEQRF 562

Query: 617 K 617
           +
Sbjct: 563 Q 563


>gi|6005997 double C2-like domains, beta [Homo sapiens]
          Length = 412

 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 73/271 (26%), Positives = 116/271 (42%), Gaps = 42/271 (15%)

Query: 359 SITLLEG-KNVSGGSMTEMFVQLKL-----GDQRYKSKTLCKSANPQWQEQFDFHYFSDR 412
           +IT  +G K +    + + +V+L L        + ++KTL  + NP W E   ++  +D 
Sbjct: 146 TITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDE 205

Query: 413 MGI---LDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTP 469
             I   L I V  +D  +H E +G  +V +  L         + L+  L           
Sbjct: 206 DMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFNICLEKQLPV--------- 256

Query: 470 CAGVSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGK 529
                          D +E K + +R  +  SLK       L V +++ A L A D +G 
Sbjct: 257 ---------------DKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGY 301

Query: 530 SDPFCLLELGND-----RLQTHTVYKNLNPEWNKVFTFPIKD---IHDVLEVTVFDEDGD 581
           SDP+    L  D     + +T    K LNPE+N+ F + IK        LEVTV+D D  
Sbjct: 302 SDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIG 361

Query: 582 KPPDFLGKVAIPLLSIRDGQPNCY-VLKNKD 611
           K  DF+G V + + +  +   + +  LKNKD
Sbjct: 362 KSNDFIGGVVLGIHAKGERLKHWFDCLKNKD 392



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 61/256 (23%), Positives = 102/256 (39%), Gaps = 40/256 (15%)

Query: 200 LKEGRNLVVRDRCGTSDPYVKFKL----NGKTLYKSKVIYKNLNPVWDEIV----VLPIQ 251
           + + + L   D  G +DPYVK  L    +     ++K +   LNP W+E +    +    
Sbjct: 147 ITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDED 206

Query: 252 SLDQKLRVKVYDRD-LTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLEDDMGVIVLN 310
            + + LR+ V D D    ++F+G   V L  L+ N T    + LE               
Sbjct: 207 MIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFNICLEK-------------- 252

Query: 311 LNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGKNVSG 370
             L V + + K      R  +S   SS           +K  L  GI+    L   + +G
Sbjct: 253 -QLPVDKTEDKSLEERGRILISLKYSS-----------QKQGLLVGIVRCAHLAAMDANG 300

Query: 371 GSMTEMFVQLKLG-DQRYKSKTLC--KSANPQWQEQFDFHYFSDRMG--ILDIEVWGKDN 425
            S   +   L+   D++ K KT    K+ NP++ E+F +      +    L++ VW  D 
Sbjct: 301 YSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDI 360

Query: 426 KKHEERLGTCKVDISA 441
            K  + +G   + I A
Sbjct: 361 GKSNDFIGGVVLGIHA 376


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 45/142 (31%), Positives = 75/142 (52%), Gaps = 4/142 (2%)

Query: 487  SERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTH 546
            +E+K+  + Y +++  +    +G L V V++  +L      GKS+P+C + +G+    T 
Sbjct: 1576 TEKKKREKAYLVRS--QRATGIGRLMVNVVEGIELKPCRSHGKSNPYCEVTMGSQCHITK 1633

Query: 547  TVYKNLNPEWNKVFTFPIKDI-HDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQ-PNC 604
            T+   LNP+WN    F I+D+  +VL +TVF+ D   P DFLG+  I +  I+  Q    
Sbjct: 1634 TIQDTLNPKWNSNCQFFIRDLEQEVLCITVFERDQFSPDDFLGRTEIRVADIKKDQGSKG 1693

Query: 605  YVLKNKDLEQAFKGVIYLEMDL 626
             V K   L +   G I + +DL
Sbjct: 1694 PVTKCLLLHEVPTGEIVVRLDL 1715



 Score = 39.3 bits (90), Expect = 0.016
 Identities = 35/125 (28%), Positives = 63/125 (50%), Gaps = 14/125 (11%)

Query: 196  LTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVLPIQSLDQ 255
            L +++ EG  L      G S+PY +  + G   + +K I   LNP W+      I+ L+Q
Sbjct: 1598 LMVNVVEGIELKPCRSHGKSNPYCEVTM-GSQCHITKTIQDTLNPKWNSNCQFFIRDLEQ 1656

Query: 256  K-LRVKVYDRD-LTTSDFMGSAFVILSDLELNR-----TTEHILKLEDPNSLEDDMGVIV 308
            + L + V++RD  +  DF+G   + ++D++ ++      T+ +L  E P       G IV
Sbjct: 1657 EVLCITVFERDQFSPDDFLGRTEIRVADIKKDQGSKGPVTKCLLLHEVPT------GEIV 1710

Query: 309  LNLNL 313
            + L+L
Sbjct: 1711 VRLDL 1715



 Score = 34.3 bits (77), Expect = 0.52
 Identities = 23/106 (21%), Positives = 48/106 (45%), Gaps = 5/106 (4%)

Query: 356  GIISITLLEG---KNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDR 412
            G + + ++EG   K       +  + ++ +G Q + +KT+  + NP+W     F      
Sbjct: 1596 GRLMVNVVEGIELKPCRSHGKSNPYCEVTMGSQCHITKTIQDTLNPKWNSNCQFFIRDLE 1655

Query: 413  MGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCL 458
              +L I V+ +D    ++ LG  + +I    +K+    + P+  CL
Sbjct: 1656 QEVLCITVFERDQFSPDDFLG--RTEIRVADIKKDQGSKGPVTKCL 1699


>gi|67763814 death-inducing-protein [Homo sapiens]
          Length = 578

 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 50/184 (27%), Positives = 86/184 (46%), Gaps = 6/184 (3%)

Query: 642 EKRFVEDSRKLSKKILSRDVDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFAVFLITV 701
           E+  VE    LS + L+ ++ R+KR    + N ++ L +   W S   S IAF V++  V
Sbjct: 186 EENTVETEEPLSARRLTENMRRLKRGAKPVTNFVKNLSALSDWYSVYTSAIAFTVYMNAV 245

Query: 702 WNFELYMIPLALLLIFVYNFIRPVKGKVSSIQDSQESTDIDDEEDEDDKESEKKGLIERI 761
           W+   + IPL L L  +   +  +  +   IQ S     + +  +  +   E   + E+ 
Sbjct: 246 WHG--WAIPLFLFLAILRLSLNYLIARGWRIQWSI----VPEVSEPVEPPKEDLTVSEKF 299

Query: 762 YMVQDIVSTVQNVLEEIASFGERIKNTFNWTVPFLSSLACLILAAATIILYFIPLRYIIL 821
            +V D+    QN+  ++A   E+IKN F W  P ++    + L AA +   F P R + L
Sbjct: 300 QLVLDVAQKAQNLFGKMADILEKIKNLFMWVQPEITQKLYVALWAAFLASCFFPYRLVGL 359

Query: 822 IWGI 825
             G+
Sbjct: 360 AVGL 363


>gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]
          Length = 694

 Score = 66.6 bits (161), Expect = 9e-11
 Identities = 70/277 (25%), Positives = 118/277 (42%), Gaps = 26/277 (9%)

Query: 355 NGIISITLLEGKNVS---GGSMTEMFVQLKL-----GDQRYKSKTLCKSANPQWQEQFDF 406
           N  +  T+++ K +       + + +V+L L        + ++KTL  + NP W E   +
Sbjct: 406 NSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVY 465

Query: 407 HYFSD---RMGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLM 463
           H  +D   +   L I V  +D   H E +G  +  +  L   Q     + L+  +     
Sbjct: 466 HGITDEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKPNQRKNFNICLERVIPMKRA 525

Query: 464 LVTLTPCAGVSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLA 523
             T +        +  V  + D+ ER +I        SL      G L V +++   L A
Sbjct: 526 GTTGSARGMALYEEEQVERVGDIEERGKILV------SLMYSTQQGGLIVGIIRCVHLAA 579

Query: 524 ADFSGKSDPFCLLELGND-----RLQTHTVYKNLNPEWNKVFTFPIKD---IHDVLEVTV 575
            D +G SDPF  L L  D     + +T    K LNPE+N+ F + IK        L+++V
Sbjct: 580 MDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISV 639

Query: 576 FDEDGDKPPDFLGKVAIPLLSIRDGQPNCY-VLKNKD 611
           +D D  K  D++G   + + +  +   + Y  LKNKD
Sbjct: 640 WDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKD 676



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 62/260 (23%), Positives = 117/260 (45%), Gaps = 34/260 (13%)

Query: 202 EGRNLVVRDRCGTSDPYVKFKL----NGKTLYKSKVIYKNLNPVWDEIVV---LPIQSLD 254
           + + L   D  G +DPYVK  L    +     ++K +    NP+W+E +V   +  + + 
Sbjct: 415 KAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQ 474

Query: 255 QK-LRVKVYDRD-LTTSDFMGSAFVILSDLELNRTT------EHILKLEDPNSLEDDMGV 306
           +K LR+ V D D    ++F+G     L  L+ N+        E ++ ++   +     G+
Sbjct: 475 RKTLRISVCDEDKFGHNEFIGETRFSLKKLKPNQRKNFNICLERVIPMKRAGTTGSARGM 534

Query: 307 IVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGK 366
            +     V + GD +      R ++  S         L  S ++  L  GII    L   
Sbjct: 535 ALYEEEQVERVGDIEE-----RGKILVS---------LMYSTQQGGLIVGIIRCVHLAAM 580

Query: 367 NVSGGS--MTEMFVQLKLGDQ-RYKSKTLCKSANPQWQEQF--DFHYFSDRMGILDIEVW 421
           + +G S    +++++  +G + ++K++   K+ NP++ E+F  D  +       LDI VW
Sbjct: 581 DANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVW 640

Query: 422 GKDNKKHEERLGTCKVDISA 441
             D  K  + +G C++ ISA
Sbjct: 641 DYDIGKSNDYIGGCQLGISA 660



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 34/127 (26%), Positives = 59/127 (46%), Gaps = 9/127 (7%)

Query: 484 ADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLEL----- 538
           A+  +  + T    L+ SL   +D   LQ  ++KA  L   D +G +DP+  L L     
Sbjct: 382 ANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGAS 441

Query: 539 GNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDV----LEVTVFDEDGDKPPDFLGKVAIPL 594
            +++L+T T+    NP WN+   +      D+    L ++V DED     +F+G+    L
Sbjct: 442 KSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKFGHNEFIGETRFSL 501

Query: 595 LSIRDGQ 601
             ++  Q
Sbjct: 502 KKLKPNQ 508


>gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens]
          Length = 690

 Score = 66.6 bits (161), Expect = 9e-11
 Identities = 70/277 (25%), Positives = 118/277 (42%), Gaps = 26/277 (9%)

Query: 355 NGIISITLLEGKNVS---GGSMTEMFVQLKL-----GDQRYKSKTLCKSANPQWQEQFDF 406
           N  +  T+++ K +       + + +V+L L        + ++KTL  + NP W E   +
Sbjct: 402 NSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVY 461

Query: 407 HYFSD---RMGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLM 463
           H  +D   +   L I V  +D   H E +G  +  +  L   Q     + L+  +     
Sbjct: 462 HGITDEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKPNQRKNFNICLERVIPMKRA 521

Query: 464 LVTLTPCAGVSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLA 523
             T +        +  V  + D+ ER +I        SL      G L V +++   L A
Sbjct: 522 GTTGSARGMALYEEEQVERVGDIEERGKILV------SLMYSTQQGGLIVGIIRCVHLAA 575

Query: 524 ADFSGKSDPFCLLELGND-----RLQTHTVYKNLNPEWNKVFTFPIKD---IHDVLEVTV 575
            D +G SDPF  L L  D     + +T    K LNPE+N+ F + IK        L+++V
Sbjct: 576 MDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISV 635

Query: 576 FDEDGDKPPDFLGKVAIPLLSIRDGQPNCY-VLKNKD 611
           +D D  K  D++G   + + +  +   + Y  LKNKD
Sbjct: 636 WDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKD 672



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 62/260 (23%), Positives = 117/260 (45%), Gaps = 34/260 (13%)

Query: 202 EGRNLVVRDRCGTSDPYVKFKL----NGKTLYKSKVIYKNLNPVWDEIVV---LPIQSLD 254
           + + L   D  G +DPYVK  L    +     ++K +    NP+W+E +V   +  + + 
Sbjct: 411 KAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQ 470

Query: 255 QK-LRVKVYDRD-LTTSDFMGSAFVILSDLELNRTT------EHILKLEDPNSLEDDMGV 306
           +K LR+ V D D    ++F+G     L  L+ N+        E ++ ++   +     G+
Sbjct: 471 RKTLRISVCDEDKFGHNEFIGETRFSLKKLKPNQRKNFNICLERVIPMKRAGTTGSARGM 530

Query: 307 IVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGK 366
            +     V + GD +      R ++  S         L  S ++  L  GII    L   
Sbjct: 531 ALYEEEQVERVGDIEE-----RGKILVS---------LMYSTQQGGLIVGIIRCVHLAAM 576

Query: 367 NVSGGS--MTEMFVQLKLGDQ-RYKSKTLCKSANPQWQEQF--DFHYFSDRMGILDIEVW 421
           + +G S    +++++  +G + ++K++   K+ NP++ E+F  D  +       LDI VW
Sbjct: 577 DANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVW 636

Query: 422 GKDNKKHEERLGTCKVDISA 441
             D  K  + +G C++ ISA
Sbjct: 637 DYDIGKSNDYIGGCQLGISA 656



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 34/127 (26%), Positives = 59/127 (46%), Gaps = 9/127 (7%)

Query: 484 ADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLEL----- 538
           A+  +  + T    L+ SL   +D   LQ  ++KA  L   D +G +DP+  L L     
Sbjct: 378 ANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGAS 437

Query: 539 GNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDV----LEVTVFDEDGDKPPDFLGKVAIPL 594
            +++L+T T+    NP WN+   +      D+    L ++V DED     +F+G+    L
Sbjct: 438 KSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKFGHNEFIGETRFSL 497

Query: 595 LSIRDGQ 601
             ++  Q
Sbjct: 498 KKLKPNQ 504


>gi|122937514 unc-13 homolog C [Homo sapiens]
          Length = 2214

 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 36/127 (28%), Positives = 68/127 (53%), Gaps = 11/127 (8%)

Query: 511  LQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDV 570
            + + V+ A  L A D +G SDP+  +++G ++ +T T++ NLNP W++ F F   +  D 
Sbjct: 1222 ITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNLNPVWDEKFYFECHNSTDR 1281

Query: 571  LEVTVFDEDGD-----------KPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGV 619
            ++V V+DED D           +  DFLG+  + + ++       Y L+ +  + A  G 
Sbjct: 1282 IKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEMDVWYNLEKRTDKSAVSGA 1341

Query: 620  IYLEMDL 626
            I L++++
Sbjct: 1342 IRLKINV 1348



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 39/139 (28%), Positives = 66/139 (47%), Gaps = 15/139 (10%)

Query: 190  SPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVLP 249
            S ++  +TI +   + L  +D+ G+SDPYV  ++ GK   ++K I+ NLNPVWDE     
Sbjct: 1216 SKWSAKITITVVSAQGLQAKDKTGSSDPYVTVQV-GKNKRRTKTIFGNLNPVWDEKFYFE 1274

Query: 250  IQSLDQKLRVKVYDRD------------LTTSDFMGSAFVILSDLELNRTTEHILKLEDP 297
              +   +++V+V+D D              + DF+G   V +  L       + L+    
Sbjct: 1275 CHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEMDVWYNLEKRTD 1334

Query: 298  NSLEDDMGVIVLNLNLVVK 316
             S     G I L +N+ +K
Sbjct: 1335 KSAVS--GAIRLKINVEIK 1351



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 29/107 (27%), Positives = 56/107 (52%), Gaps = 23/107 (21%)

Query: 354  WNGIISITL-----LEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDF-- 406
            W+  I+IT+     L+ K+ +G S  + +V +++G  + ++KT+  + NP W E+F F  
Sbjct: 1218 WSAKITITVVSAQGLQAKDKTGSS--DPYVTVQVGKNKRRTKTIFGNLNPVWDEKFYFEC 1275

Query: 407  HYFSDRMGILDIEVWGKDN-----------KKHEERLGTCKVDISAL 442
            H  +DR   + + VW +D+           K+ ++ LG   V++  L
Sbjct: 1276 HNSTDR---IKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTL 1319


>gi|38570146 synaptotagmin VII [Homo sapiens]
          Length = 403

 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 48/132 (36%), Positives = 64/132 (48%), Gaps = 7/132 (5%)

Query: 511 LQVKVLKAADLLAADFSGKSDPFCLLELGND---RLQTHTVYKNLNPEWNKVFTFP---- 563
           L VK++KA +L A DFSG SDPF  + L  D   +L+T    KNLNP WN+ F F     
Sbjct: 152 LTVKIMKAQELPAKDFSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFEGFPY 211

Query: 564 IKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGVIYLE 623
            K +  +L + V D D     D +G+V+IPL  +   Q   +    K           L 
Sbjct: 212 EKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCSDGSGSRGELL 271

Query: 624 MDLIYNPVKASI 635
           + L YNP   SI
Sbjct: 272 LSLCYNPSANSI 283



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 81/323 (25%), Positives = 130/323 (40%), Gaps = 60/323 (18%)

Query: 283 ELNRTTEHILKLED-PNSLEDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRN 341
           E +R TE    + D  NSL  +M      L L     + + H   +R+ L   + S+  N
Sbjct: 93  ESDRRTEPRSSVSDLVNSLTSEM------LMLSPGSEEDEAHEGCSRENLGRIQFSVGYN 146

Query: 342 LRLSESLKKNQLWNGIISITLLEGKNVSGGSMTEMFVQLKL-GDQRYKSKTLCK--SANP 398
            + S    K      I+    L  K+ SG S  + FV++ L  D+++K +T  K  + NP
Sbjct: 147 FQESTLTVK------IMKAQELPAKDFSGTS--DPFVKIYLLPDKKHKLETKVKRKNLNP 198

Query: 399 QWQEQFDFHYFSDR---MGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLD 455
            W E F F  F        IL ++V   D     + +G   + ++ + L Q       L 
Sbjct: 199 HWNETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLK 258

Query: 456 SCLGALLMLVTLTPCAGVSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKV 515
            C          +   G  +  LC  P A+                         + V +
Sbjct: 259 PCSDG-------SGSRGELLLSLCYNPSANS------------------------IIVNI 287

Query: 516 LKAADLLAADFSGKSDPFCLLEL-----GNDRLQTHTVYKNLNPEWNKVFTFPI---KDI 567
           +KA +L A D  G SDP+  + L       ++ +T T+ +NLNP +N+ F F I   K  
Sbjct: 288 IKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTMKRNLNPIFNESFAFDIPTEKLR 347

Query: 568 HDVLEVTVFDEDGDKPPDFLGKV 590
              + +TV D+D     D +GK+
Sbjct: 348 ETTIIITVMDKDKLSRNDVIGKI 370



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 72/298 (24%), Positives = 128/298 (42%), Gaps = 59/298 (19%)

Query: 161 SDLNASMTSQHF-------EEQSVPGEASDGLSNLPSPFAY-----LLTIHLKEGRNLVV 208
           SDL  S+TS+         E+++  G + + L  +     Y      LT+ + + + L  
Sbjct: 105 SDLVNSLTSEMLMLSPGSEEDEAHEGCSRENLGRIQFSVGYNFQESTLTVKIMKAQELPA 164

Query: 209 RDRCGTSDPYVKFKL--NGKTLYKSKVIYKNLNPVWDEIVV---LPIQSLDQK---LRVK 260
           +D  GTSDP+VK  L  + K   ++KV  KNLNP W+E  +    P + + Q+   L+V 
Sbjct: 165 KDFSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFEGFPYEKVVQRILYLQVL 224

Query: 261 VYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLEDDMGVIVLNLNLVVKQGDF 320
            YDR  + +D +G   + L+ ++L +       L+  +      G ++L+L         
Sbjct: 225 DYDR-FSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCSDGSGSRGELLLSL--------- 274

Query: 321 KRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGKNVSGGSMTEMFVQL 380
                      + S +S+I N               II    L+  ++ G S   + V L
Sbjct: 275 ---------CYNPSANSIIVN---------------IIKARNLKAMDIGGTSDPYVKVWL 310

Query: 381 KLGDQRYKSK---TLCKSANPQWQEQFDFHYFSDRM--GILDIEVWGKDNKKHEERLG 433
              D+R + K   T+ ++ NP + E F F   ++++    + I V  KD     + +G
Sbjct: 311 MYKDKRVEKKKTVTMKRNLNPIFNESFAFDIPTEKLRETTIIITVMDKDKLSRNDVIG 368



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 35/103 (33%), Positives = 56/103 (54%), Gaps = 12/103 (11%)

Query: 185 LSNLPSPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKL--NGKTLYKSKVI--YKNLNP 240
           LS   +P A  + +++ + RNL   D  GTSDPYVK  L    K + K K +   +NLNP
Sbjct: 272 LSLCYNPSANSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTMKRNLNP 331

Query: 241 VWDEIVVLPIQSLDQKLR-----VKVYDRD-LTTSDFMGSAFV 277
           +++E     I +  +KLR     + V D+D L+ +D +G  ++
Sbjct: 332 IFNESFAFDIPT--EKLRETTIIITVMDKDKLSRNDVIGKIYL 372


>gi|21361472 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 3 [Homo sapiens]
          Length = 955

 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 46/137 (33%), Positives = 67/137 (48%), Gaps = 15/137 (10%)

Query: 503 KDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLEL----GNDRL---QTHTVYKNLNPE 555
           +D  +  IL+VKV+   DL   D  G SDP+  L L     N  L   QT T+ K LNP+
Sbjct: 14  EDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPK 73

Query: 556 WNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNC--------YVL 607
           WN+ F F +   +  L   VFDE+     DFLG+V +PL  +    P          ++L
Sbjct: 74  WNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLL 133

Query: 608 KNKDLEQAFKGVIYLEM 624
           + +  +   KG + L+M
Sbjct: 134 RPRSHKSRVKGFLRLKM 150



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 37/115 (32%), Positives = 55/115 (47%), Gaps = 12/115 (10%)

Query: 195 LLTIHLKEGRNLVVRDRCGTSDPYVKFKL------NGKTLYKSKVIYKNLNPVWDEIVVL 248
           +L + +  G +L  +D  G SDPYVK  L          L ++K I K LNP W+E    
Sbjct: 21  ILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYF 80

Query: 249 PIQSLDQKLRVKVYDRD-LTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLED 302
            +   + +L  +V+D + LT  DF+G   V LS L     T     +E P + +D
Sbjct: 81  RVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPT-----MERPYTFKD 130



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 25/92 (27%), Positives = 46/92 (50%), Gaps = 6/92 (6%)

Query: 357 IISITLLEGKNVSGGSMTEMFVQLKLGDQR-----YKSKTLCKSANPQWQEQFDFHYFSD 411
           ++S   L  K++ G S   + + L + D+       ++KT+ K+ NP+W E+F F     
Sbjct: 26  VVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPS 85

Query: 412 RMGILDIEVWGKDNKKHEERLGTCKVDISALP 443
              +L  EV+ ++    ++ LG   V +S LP
Sbjct: 86  NHRLL-FEVFDENRLTRDDFLGQVDVPLSHLP 116


>gi|222352086 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 1 [Homo sapiens]
          Length = 975

 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 46/137 (33%), Positives = 67/137 (48%), Gaps = 15/137 (10%)

Query: 503 KDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLEL----GNDRL---QTHTVYKNLNPE 555
           +D  +  IL+VKV+   DL   D  G SDP+  L L     N  L   QT T+ K LNP+
Sbjct: 14  EDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPK 73

Query: 556 WNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNC--------YVL 607
           WN+ F F +   +  L   VFDE+     DFLG+V +PL  +    P          ++L
Sbjct: 74  WNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLL 133

Query: 608 KNKDLEQAFKGVIYLEM 624
           + +  +   KG + L+M
Sbjct: 134 RPRSHKSRVKGFLRLKM 150



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 37/115 (32%), Positives = 55/115 (47%), Gaps = 12/115 (10%)

Query: 195 LLTIHLKEGRNLVVRDRCGTSDPYVKFKL------NGKTLYKSKVIYKNLNPVWDEIVVL 248
           +L + +  G +L  +D  G SDPYVK  L          L ++K I K LNP W+E    
Sbjct: 21  ILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYF 80

Query: 249 PIQSLDQKLRVKVYDRD-LTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLED 302
            +   + +L  +V+D + LT  DF+G   V LS L     T     +E P + +D
Sbjct: 81  RVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPT-----MERPYTFKD 130



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 25/92 (27%), Positives = 46/92 (50%), Gaps = 6/92 (6%)

Query: 357 IISITLLEGKNVSGGSMTEMFVQLKLGDQR-----YKSKTLCKSANPQWQEQFDFHYFSD 411
           ++S   L  K++ G S   + + L + D+       ++KT+ K+ NP+W E+F F     
Sbjct: 26  VVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPS 85

Query: 412 RMGILDIEVWGKDNKKHEERLGTCKVDISALP 443
              +L  EV+ ++    ++ LG   V +S LP
Sbjct: 86  NHRLL-FEVFDENRLTRDDFLGQVDVPLSHLP 116


>gi|222352090 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 5 [Homo sapiens]
          Length = 947

 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 45/130 (34%), Positives = 64/130 (49%), Gaps = 15/130 (11%)

Query: 510 ILQVKVLKAADLLAADFSGKSDPFCLLEL----GNDRL---QTHTVYKNLNPEWNKVFTF 562
           IL+VKV+   DL   D  G SDP+  L L     N  L   QT T+ K LNP+WN+ F F
Sbjct: 13  ILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYF 72

Query: 563 PIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNC--------YVLKNKDLEQ 614
            +   +  L   VFDE+     DFLG+V +PL  +    P          ++L+ +  + 
Sbjct: 73  RVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKS 132

Query: 615 AFKGVIYLEM 624
             KG + L+M
Sbjct: 133 RVKGFLRLKM 142



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 37/115 (32%), Positives = 55/115 (47%), Gaps = 12/115 (10%)

Query: 195 LLTIHLKEGRNLVVRDRCGTSDPYVKFKL------NGKTLYKSKVIYKNLNPVWDEIVVL 248
           +L + +  G +L  +D  G SDPYVK  L          L ++K I K LNP W+E    
Sbjct: 13  ILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYF 72

Query: 249 PIQSLDQKLRVKVYDRD-LTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLED 302
            +   + +L  +V+D + LT  DF+G   V LS L     T     +E P + +D
Sbjct: 73  RVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPT-----MERPYTFKD 122



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 25/92 (27%), Positives = 46/92 (50%), Gaps = 6/92 (6%)

Query: 357 IISITLLEGKNVSGGSMTEMFVQLKLGDQR-----YKSKTLCKSANPQWQEQFDFHYFSD 411
           ++S   L  K++ G S   + + L + D+       ++KT+ K+ NP+W E+F F     
Sbjct: 18  VVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPS 77

Query: 412 RMGILDIEVWGKDNKKHEERLGTCKVDISALP 443
              +L  EV+ ++    ++ LG   V +S LP
Sbjct: 78  NHRLL-FEVFDENRLTRDDFLGQVDVPLSHLP 108


>gi|222352088 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 4 [Homo sapiens]
          Length = 967

 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 45/130 (34%), Positives = 64/130 (49%), Gaps = 15/130 (11%)

Query: 510 ILQVKVLKAADLLAADFSGKSDPFCLLEL----GNDRL---QTHTVYKNLNPEWNKVFTF 562
           IL+VKV+   DL   D  G SDP+  L L     N  L   QT T+ K LNP+WN+ F F
Sbjct: 13  ILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYF 72

Query: 563 PIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNC--------YVLKNKDLEQ 614
            +   +  L   VFDE+     DFLG+V +PL  +    P          ++L+ +  + 
Sbjct: 73  RVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKS 132

Query: 615 AFKGVIYLEM 624
             KG + L+M
Sbjct: 133 RVKGFLRLKM 142



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 37/115 (32%), Positives = 55/115 (47%), Gaps = 12/115 (10%)

Query: 195 LLTIHLKEGRNLVVRDRCGTSDPYVKFKL------NGKTLYKSKVIYKNLNPVWDEIVVL 248
           +L + +  G +L  +D  G SDPYVK  L          L ++K I K LNP W+E    
Sbjct: 13  ILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYF 72

Query: 249 PIQSLDQKLRVKVYDRD-LTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLED 302
            +   + +L  +V+D + LT  DF+G   V LS L     T     +E P + +D
Sbjct: 73  RVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPT-----MERPYTFKD 122



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 25/92 (27%), Positives = 46/92 (50%), Gaps = 6/92 (6%)

Query: 357 IISITLLEGKNVSGGSMTEMFVQLKLGDQR-----YKSKTLCKSANPQWQEQFDFHYFSD 411
           ++S   L  K++ G S   + + L + D+       ++KT+ K+ NP+W E+F F     
Sbjct: 18  VVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPS 77

Query: 412 RMGILDIEVWGKDNKKHEERLGTCKVDISALP 443
              +L  EV+ ++    ++ LG   V +S LP
Sbjct: 78  NHRLL-FEVFDENRLTRDDFLGQVDVPLSHLP 108


>gi|122937247 unc-13 homolog A [Homo sapiens]
          Length = 1791

 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 38/127 (29%), Positives = 63/127 (49%), Gaps = 11/127 (8%)

Query: 511 LQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDV 570
           + + V+ A  L A D +G SDP+  +++G  + +T T+Y NLNP W + F F   +  D 
Sbjct: 766 ISITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDR 825

Query: 571 LEVTVFDEDGD-----------KPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGV 619
           ++V V+DED D           +  DFLG+  I + ++       Y L  +  + A  G 
Sbjct: 826 IKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSGEMDVWYNLDKRTDKSAVSGA 885

Query: 620 IYLEMDL 626
           I L + +
Sbjct: 886 IRLHISV 892



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 27/76 (35%), Positives = 47/76 (61%), Gaps = 1/76 (1%)

Query: 190 SPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVLP 249
           S ++  ++I +   + L  +D+ G+SDPYV  ++ GKT  ++K IY NLNPVW+E     
Sbjct: 760 SKWSAKISITVVCAQGLQAKDKTGSSDPYVTVQV-GKTKKRTKTIYGNLNPVWEENFHFE 818

Query: 250 IQSLDQKLRVKVYDRD 265
             +   +++V+V+D D
Sbjct: 819 CHNSSDRIKVRVWDED 834



 Score = 43.5 bits (101), Expect = 9e-04
 Identities = 26/79 (32%), Positives = 46/79 (58%), Gaps = 12/79 (15%)

Query: 354 WNGIISITL-----LEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDF-- 406
           W+  ISIT+     L+ K+ +G S  + +V +++G  + ++KT+  + NP W+E F F  
Sbjct: 762 WSAKISITVVCAQGLQAKDKTGSS--DPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFEC 819

Query: 407 HYFSDRMGILDIEVWGKDN 425
           H  SDR   + + VW +D+
Sbjct: 820 HNSSDR---IKVRVWDEDD 835


>gi|47078261 double C2-like domains, alpha [Homo sapiens]
          Length = 400

 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 62/222 (27%), Positives = 96/222 (43%), Gaps = 21/222 (9%)

Query: 386 RYKSKTLCKSANPQWQEQFDFHYFSD---RMGILDIEVWGKDNKKHEERLGTCKVDISAL 442
           + K+KT   + NP W E   +   +D      +L I V  +D   H E +G  +V +  L
Sbjct: 142 KLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRL 201

Query: 443 PLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCVCPLADLSERKQ----ITQRYCL 498
              Q     + L+  +             G+S      C L +L + +Q    + +R  +
Sbjct: 202 KPSQKKHFNICLERQVPLASPSSMSAALRGIS------CYLKELEQAEQGQGLLEERGRI 255

Query: 499 QNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGND-----RLQTHTVYKNLN 553
             SL        L V +L+ A L A D +G SDP+    L  D     + +T    K LN
Sbjct: 256 LLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLN 315

Query: 554 PEWNKVFTFPIKD---IHDVLEVTVFDEDGDKPPDFLGKVAI 592
           PE+N+ F + I+        LEVTV+D D  K  DF+G V++
Sbjct: 316 PEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSL 357



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 34/100 (34%), Positives = 52/100 (52%), Gaps = 9/100 (9%)

Query: 511 LQVKVLKAADLLAADFSGKSDPFCLLEL-----GNDRLQTHTVYKNLNPEWNKVFTFP-I 564
           L   +L+A  L   DF+G +DP+  L L       ++L+T T    LNP WN+  T+  I
Sbjct: 106 LHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGI 165

Query: 565 KD---IHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQ 601
            D    H VL + V DED     +F+G++ +PL  ++  Q
Sbjct: 166 TDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQ 205



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 90/358 (25%), Positives = 146/358 (40%), Gaps = 43/358 (12%)

Query: 147 GGDAPEEPEKLC---GSSDLNASMTSQHFEEQSVPGEASDGLSNLPSPFAY---LLTIH- 199
           GG+AP     L     ++ L A+      E  S   + +  L  L     Y     T+H 
Sbjct: 49  GGEAPAHLVPLALAPPAALLGATTPEDGAEVDSYDSDDATALGTLEFDLLYDRASCTLHC 108

Query: 200 -LKEGRNLVVRDRCGTSDPYVKFKLNGKTL----YKSKVIYKNLNPVWDEIV----VLPI 250
            +   + L   D  G +DPYVK  L          K+K     LNPVW+E +    +   
Sbjct: 109 SILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDD 168

Query: 251 QSLDQKLRVKVYDRD-LTTSDFMGSAFVILSDLE------LNRTTEHILKLEDPNSLEDD 303
               + LR+ V D D L+ ++F+G   V L  L+       N   E  + L  P+S+   
Sbjct: 169 DITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAA 228

Query: 304 MGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLL 363
           +  I   L   ++Q +  +     R R+          L LS S ++  L  GI+    L
Sbjct: 229 LRGISCYLK-ELEQAEQGQGLLEERGRIL---------LSLSYSSRRRGLLVGILRCAHL 278

Query: 364 EGKNVSGGSMTEMFVQLKLG-DQRYKSKTLC--KSANPQWQEQFDFHYFSDRMG--ILDI 418
              +V+G S   +   L+   D++ K KT    K+ NP++ E+F +      +    L++
Sbjct: 279 AAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEV 338

Query: 419 EVWGKDNKKHEERLGTCKVDISALPLKQ---ANCLELPLDSCLGALLMLVT-LTPCAG 472
            VW  D  K  + +G   +   A    +   ++CL+ P D+ L     L + L P AG
Sbjct: 339 TVWDYDIGKSNDFIGGVSLGPGARGEARKHWSDCLQQP-DAALERWHTLTSELPPAAG 395


>gi|110611226 UNC13 (C. elegans)-like [Homo sapiens]
          Length = 1591

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 36/127 (28%), Positives = 64/127 (50%), Gaps = 11/127 (8%)

Query: 511 LQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDV 570
           + + V+ A  L A D +G SDP+  +++   + +T T++ NLNP W + F F   +  D 
Sbjct: 602 ITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSDR 661

Query: 571 LEVTVFDEDGD-----------KPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGV 619
           ++V V+DED D           +  DFLG+  I + ++       Y L+ +  + A  G 
Sbjct: 662 IKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGA 721

Query: 620 IYLEMDL 626
           I L++ +
Sbjct: 722 IRLQISV 728



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 26/76 (34%), Positives = 47/76 (61%), Gaps = 1/76 (1%)

Query: 190 SPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVLP 249
           S ++  +TI +   + L  +D+ G+SDPYV  +++ KT  ++K I+ NLNPVW+E     
Sbjct: 596 SKWSAKITITVVCAQGLQAKDKTGSSDPYVTVQVS-KTKKRTKTIFGNLNPVWEEKFHFE 654

Query: 250 IQSLDQKLRVKVYDRD 265
             +   +++V+V+D D
Sbjct: 655 CHNSSDRIKVRVWDED 670



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 24/79 (30%), Positives = 46/79 (58%), Gaps = 12/79 (15%)

Query: 354 WNGIISITL-----LEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDF-- 406
           W+  I+IT+     L+ K+ +G S  + +V +++   + ++KT+  + NP W+E+F F  
Sbjct: 598 WSAKITITVVCAQGLQAKDKTGSS--DPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFEC 655

Query: 407 HYFSDRMGILDIEVWGKDN 425
           H  SDR   + + VW +D+
Sbjct: 656 HNSSDR---IKVRVWDEDD 671


>gi|45504376 synaptotagmin VI [Homo sapiens]
          Length = 425

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 83/315 (26%), Positives = 130/315 (41%), Gaps = 72/315 (22%)

Query: 142 QKTSLGGDAPEEPEKLCGSSDLNASMTSQHFEEQSVPGEASDGLSNLPSPFAYLLTIHLK 201
           QK+  G DA  E  K CG   +N S+   +  E                     L + + 
Sbjct: 129 QKSVDGEDAKSEATKSCGK--INFSLRYDYETET--------------------LIVRIL 166

Query: 202 EGRNLVVRDRCGTSDPYVKFKL--NGKTLYKSKVIYKNLNPVWDEIVVLPI---QSLDQK 256
           +  +L  +D CG+SDPYVK  L  + K   +++V  K LNP +DE    P+   +  D+K
Sbjct: 167 KAFDLPAKDFCGSSDPYVKIYLLPDRKCKLQTRVHRKTLNPTFDENFHFPVPYEELADRK 226

Query: 257 LRVKVYDRD-LTTSDFMGSAFVILSDL----ELNRTTEHILKLEDPNSLEDDMGVIVLNL 311
           L + V+D D  +  D +G   VIL +L    +L+R T     ++   S   D+G I+ +L
Sbjct: 227 LHLSVFDFDRFSRHDMIGE--VILDNLFEASDLSRETSIWKDIQYATSESVDLGEIMFSL 284

Query: 312 NLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGKNVSGG 371
             +   G           RL+ +                      +I    L+  +++G 
Sbjct: 285 CYLPTAG-----------RLTLT----------------------VIKCRNLKAMDITGY 311

Query: 372 SMTEMFVQLKLGDQRYKSK--TLCKSA-NPQWQEQFDFHYFSDRMG--ILDIEVWGKDNK 426
           S   + V L    +R K K  T+ K+  NP + E   F    + M    L I V   D  
Sbjct: 312 SDPYVKVSLLCDGRRLKKKKTTIKKNTLNPVYNEAIIFDIPPENMDQVSLLISVMDYDRV 371

Query: 427 KHEERLGTCKVDISA 441
            H E +G C+V I+A
Sbjct: 372 GHNEIIGVCRVGITA 386



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 38/98 (38%), Positives = 56/98 (57%), Gaps = 6/98 (6%)

Query: 501 SLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDR---LQTHTVYKNLNPEWN 557
           SL+   +   L V++LKA DL A DF G SDP+  + L  DR   LQT    K LNP ++
Sbjct: 151 SLRYDYETETLIVRILKAFDLPAKDFCGSSDPYVKIYLLPDRKCKLQTRVHRKTLNPTFD 210

Query: 558 KVFTFPI--KDIHD-VLEVTVFDEDGDKPPDFLGKVAI 592
           + F FP+  +++ D  L ++VFD D     D +G+V +
Sbjct: 211 ENFHFPVPYEELADRKLHLSVFDFDRFSRHDMIGEVIL 248



 Score = 35.0 bits (79), Expect = 0.31
 Identities = 29/87 (33%), Positives = 47/87 (54%), Gaps = 8/87 (9%)

Query: 501 SLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGND----RLQTHTVYKN-LNPE 555
           SL  +   G L + V+K  +L A D +G SDP+  + L  D    + +  T+ KN LNP 
Sbjct: 283 SLCYLPTAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLLCDGRRLKKKKTTIKKNTLNPV 342

Query: 556 WNK--VFTFPIKDIHDV-LEVTVFDED 579
           +N+  +F  P +++  V L ++V D D
Sbjct: 343 YNEAIIFDIPPENMDQVSLLISVMDYD 369


>gi|114520609 neural precursor cell expressed, developmentally
           down-regulated 4 isoform 1 [Homo sapiens]
          Length = 900

 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 43/143 (30%), Positives = 68/143 (47%), Gaps = 16/143 (11%)

Query: 502 LKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDR------LQTHTVYKNLNPE 555
           L+D ++  I++V+V+    L   D  G SDP+  + L +        +QT T+ K+LNP+
Sbjct: 12  LEDEENSRIVRVRVIAGIGLAKKDILGASDPYVRVTLYDPMNGVLTSVQTKTIKKSLNPK 71

Query: 556 WNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNC--------YVL 607
           WN+   F +      L   VFDE+     DFLG+V +PL  +    P          +VL
Sbjct: 72  WNEEILFRVHPQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENPRLERPYTFKDFVL 131

Query: 608 KNKDLEQAFKGVIYLEMDLIYNP 630
             +  +   KG  YL + + Y P
Sbjct: 132 HPRSHKSRVKG--YLRLKMTYLP 152



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 36/114 (31%), Positives = 57/114 (50%), Gaps = 11/114 (9%)

Query: 195 LLTIHLKEGRNLVVRDRCGTSDPYVKFKL----NGK-TLYKSKVIYKNLNPVWDEIVVLP 249
           ++ + +  G  L  +D  G SDPYV+  L    NG  T  ++K I K+LNP W+E ++  
Sbjct: 20  IVRVRVIAGIGLAKKDILGASDPYVRVTLYDPMNGVLTSVQTKTIKKSLNPKWNEEILFR 79

Query: 250 IQSLDQKLRVKVYDRD-LTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLED 302
           +     +L  +V+D + LT  DF+G   V L  L          +LE P + +D
Sbjct: 80  VHPQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENP-----RLERPYTFKD 128



 Score = 32.3 bits (72), Expect = 2.0
 Identities = 19/61 (31%), Positives = 33/61 (54%), Gaps = 3/61 (4%)

Query: 388 KSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGKDNKKHEERLGTCKVDISALPLKQA 447
           ++KT+ KS NP+W E+  F     +  +L  EV+ ++    ++ LG  +VD+   PL   
Sbjct: 60  QTKTIKKSLNPKWNEEILFRVHPQQHRLL-FEVFDENRLTRDDFLG--QVDVPLYPLPTE 116

Query: 448 N 448
           N
Sbjct: 117 N 117


>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
          Length = 671

 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 36/96 (37%), Positives = 59/96 (61%), Gaps = 7/96 (7%)

Query: 195 LLTIHLKEGRNLVVRDRCGTSDPYVKFKL----NGKTLYKSKVIYKNLNPVWDEIVVLPI 250
           +L + +++ +NLV  D  G SDPYVK KL      ++  K+K I  +LNP W+E     +
Sbjct: 172 VLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQL 231

Query: 251 Q--SLDQKLRVKVYDRDLTT-SDFMGSAFVILSDLE 283
           +    D++L V+++D DLT+ +DFMGS    +S+L+
Sbjct: 232 KESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQ 267



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 33/99 (33%), Positives = 53/99 (53%), Gaps = 7/99 (7%)

Query: 507 DVGILQVKVLKAADLLAADFSGKSDPFCLLELGND-----RLQTHTVYKNLNPEWNKVFT 561
           D  +L V V  A +L+  D +G SDP+  L+L  D     + +T T+  +LNPEWN+ F 
Sbjct: 169 DRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFR 228

Query: 562 FPIK--DIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIR 598
           F +K  D    L V ++D D     DF+G ++  +  ++
Sbjct: 229 FQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQ 267



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 26/95 (27%), Positives = 48/95 (50%), Gaps = 9/95 (9%)

Query: 357 IISITLLEGKNV---SGGSMTEMFVQLKL-----GDQRYKSKTLCKSANPQWQEQFDFHY 408
           ++ + + + KN+       +++ +V+LKL      + + K+KT+  S NP+W E F F  
Sbjct: 172 VLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQL 231

Query: 409 -FSDRMGILDIEVWGKDNKKHEERLGTCKVDISAL 442
             SD+   L +E+W  D     + +G+    IS L
Sbjct: 232 KESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISEL 266


>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
          Length = 673

 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 36/96 (37%), Positives = 59/96 (61%), Gaps = 7/96 (7%)

Query: 195 LLTIHLKEGRNLVVRDRCGTSDPYVKFKL----NGKTLYKSKVIYKNLNPVWDEIVVLPI 250
           +L + +++ +NLV  D  G SDPYVK KL      ++  K+K I  +LNP W+E     +
Sbjct: 172 VLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQL 231

Query: 251 Q--SLDQKLRVKVYDRDLTT-SDFMGSAFVILSDLE 283
           +    D++L V+++D DLT+ +DFMGS    +S+L+
Sbjct: 232 KESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQ 267



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 33/99 (33%), Positives = 53/99 (53%), Gaps = 7/99 (7%)

Query: 507 DVGILQVKVLKAADLLAADFSGKSDPFCLLELGND-----RLQTHTVYKNLNPEWNKVFT 561
           D  +L V V  A +L+  D +G SDP+  L+L  D     + +T T+  +LNPEWN+ F 
Sbjct: 169 DRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFR 228

Query: 562 FPIK--DIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIR 598
           F +K  D    L V ++D D     DF+G ++  +  ++
Sbjct: 229 FQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQ 267



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 26/95 (27%), Positives = 48/95 (50%), Gaps = 9/95 (9%)

Query: 357 IISITLLEGKNV---SGGSMTEMFVQLKL-----GDQRYKSKTLCKSANPQWQEQFDFHY 408
           ++ + + + KN+       +++ +V+LKL      + + K+KT+  S NP+W E F F  
Sbjct: 172 VLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQL 231

Query: 409 -FSDRMGILDIEVWGKDNKKHEERLGTCKVDISAL 442
             SD+   L +E+W  D     + +G+    IS L
Sbjct: 232 KESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISEL 266


>gi|13384594 protein kinase C, gamma [Homo sapiens]
          Length = 697

 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 37/100 (37%), Positives = 59/100 (59%), Gaps = 7/100 (7%)

Query: 190 SPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKL----NGKTLYKSKVIYKNLNPVWDEI 245
           +P A  + + + E RNL+  D  G SDPYVK KL       T  K++ +   LNPVW+E 
Sbjct: 167 APTADEIHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNET 226

Query: 246 VVLPIQ--SLDQKLRVKVYDRDLTT-SDFMGSAFVILSDL 282
            V  ++   ++++L V+V+D D T+ +DFMG+    +S+L
Sbjct: 227 FVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSEL 266



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 40/129 (31%), Positives = 62/129 (48%), Gaps = 8/129 (6%)

Query: 470 CAGVSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGK 529
           C  ++V   CV  +  L       +R  LQ  ++       + V V +A +L+  D +G 
Sbjct: 133 CCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIR-APTADEIHVTVGEARNLIPMDPNGL 191

Query: 530 SDPFCLLELGND-----RLQTHTVYKNLNPEWNKVFTFPIK--DIHDVLEVTVFDEDGDK 582
           SDP+  L+L  D     + +T TV   LNP WN+ F F +K  D+   L V V+D D   
Sbjct: 192 SDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTS 251

Query: 583 PPDFLGKVA 591
             DF+G ++
Sbjct: 252 RNDFMGAMS 260



 Score = 34.7 bits (78), Expect = 0.40
 Identities = 25/94 (26%), Positives = 44/94 (46%), Gaps = 9/94 (9%)

Query: 358 ISITLLEGKNV---SGGSMTEMFVQLKLGDQ-----RYKSKTLCKSANPQWQEQFDFHYF 409
           I +T+ E +N+       +++ +V+LKL        + K++T+  + NP W E F F+  
Sbjct: 173 IHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLK 232

Query: 410 -SDRMGILDIEVWGKDNKKHEERLGTCKVDISAL 442
             D    L +EVW  D     + +G     +S L
Sbjct: 233 PGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSEL 266


>gi|4506067 protein kinase C, alpha [Homo sapiens]
          Length = 672

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 35/94 (37%), Positives = 55/94 (58%), Gaps = 7/94 (7%)

Query: 196 LTIHLKEGRNLVVRDRCGTSDPYVKFKL----NGKTLYKSKVIYKNLNPVWDEIVVLPIQ 251
           L + +++ +NL+  D  G SDPYVK KL      ++  K+K I   LNP W+E     ++
Sbjct: 173 LHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLK 232

Query: 252 --SLDQKLRVKVYDRDLTT-SDFMGSAFVILSDL 282
               D++L V+++D D TT +DFMGS    +S+L
Sbjct: 233 PSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSEL 266



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 32/88 (36%), Positives = 48/88 (54%), Gaps = 7/88 (7%)

Query: 511 LQVKVLKAADLLAADFSGKSDPFCLLELGND-----RLQTHTVYKNLNPEWNKVFTFPIK 565
           L V V  A +L+  D +G SDP+  L+L  D     + +T T+   LNP+WN+ FTF +K
Sbjct: 173 LHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLK 232

Query: 566 --DIHDVLEVTVFDEDGDKPPDFLGKVA 591
             D    L V ++D D     DF+G ++
Sbjct: 233 PSDKDRRLSVEIWDWDRTTRNDFMGSLS 260



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 26/94 (27%), Positives = 48/94 (51%), Gaps = 9/94 (9%)

Query: 358 ISITLLEGKNV---SGGSMTEMFVQLKL-----GDQRYKSKTLCKSANPQWQEQFDFHYF 409
           + +T+ + KN+       +++ +V+LKL      + + K+KT+  + NPQW E F F   
Sbjct: 173 LHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLK 232

Query: 410 -SDRMGILDIEVWGKDNKKHEERLGTCKVDISAL 442
            SD+   L +E+W  D     + +G+    +S L
Sbjct: 233 PSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSEL 266


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,545,597
Number of Sequences: 37866
Number of extensions: 1464349
Number of successful extensions: 8466
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 83
Number of HSP's successfully gapped in prelim test: 117
Number of HSP's that attempted gapping in prelim test: 7562
Number of HSP's gapped (non-prelim): 830
length of query: 878
length of database: 18,247,518
effective HSP length: 111
effective length of query: 767
effective length of database: 14,044,392
effective search space: 10772048664
effective search space used: 10772048664
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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