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Search of human proteins with 226246577
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo
sapiens]
(581 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo sapi... 1212 0.0
gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo sapi... 1199 0.0
gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo sapi... 1002 0.0
gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens] 650 0.0
gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo sapi... 610 e-174
gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo sapi... 570 e-162
gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo sapi... 570 e-162
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 234 2e-61
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 234 2e-61
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens] 233 3e-61
gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens] 233 3e-61
gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens] 233 3e-61
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 216 6e-56
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 216 6e-56
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 216 6e-56
gi|110611226 UNC13 (C. elegans)-like [Homo sapiens] 70 5e-12
gi|122937514 unc-13 homolog C [Homo sapiens] 69 9e-12
gi|122937247 unc-13 homolog A [Homo sapiens] 69 1e-11
gi|5031689 protein kinase D3 [Homo sapiens] 67 6e-11
gi|4758532 ral guanine nucleotide dissociation stimulator-like 2... 65 1e-10
gi|5453976 protein kinase C, theta [Homo sapiens] 63 7e-10
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 63 8e-10
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 63 8e-10
gi|47157325 protein kinase C, delta [Homo sapiens] 62 1e-09
gi|31377782 protein kinase C, delta [Homo sapiens] 62 1e-09
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens] 61 2e-09
gi|4757980 beta chimerin isoform 2 [Homo sapiens] 60 7e-09
gi|91106928 beta chimerin isoform 1 [Homo sapiens] 60 7e-09
gi|13384594 protein kinase C, gamma [Homo sapiens] 60 7e-09
gi|4506067 protein kinase C, alpha [Homo sapiens] 59 9e-09
>gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo
sapiens]
Length = 581
Score = 1212 bits (3137), Expect = 0.0
Identities = 581/581 (100%), Positives = 581/581 (100%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
Query: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
Sbjct: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
Query: 301 AISRLKDSHAHLSPDSTKLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAP 360
AISRLKDSHAHLSPDSTKLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAP
Sbjct: 301 AISRLKDSHAHLSPDSTKLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAP 360
Query: 361 GVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQG 420
GVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQG
Sbjct: 361 GVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQG 420
Query: 421 RGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCR 480
RGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCR
Sbjct: 421 RGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCR 480
Query: 481 ECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPE 540
ECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPE
Sbjct: 481 ECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPE 540
Query: 541 TGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 581
TGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS
Sbjct: 541 TGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 581
>gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo
sapiens]
Length = 604
Score = 1199 bits (3103), Expect = 0.0
Identities = 581/604 (96%), Positives = 581/604 (96%), Gaps = 23/604 (3%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
Query: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
Sbjct: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
Query: 301 AISRLKDSHAHLSPDSTK-----------------------LSLDLFYTEDEIYELSYAR 337
AISRLKDSHAHLSPDSTK LSLDLFYTEDEIYELSYAR
Sbjct: 301 AISRLKDSHAHLSPDSTKELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAR 360
Query: 338 EPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQE 397
EPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQE
Sbjct: 361 EPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQE 420
Query: 398 DFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFR 457
DFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFR
Sbjct: 421 DFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFR 480
Query: 458 KPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPS 517
KPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPS
Sbjct: 481 KPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPS 540
Query: 518 TPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASS 577
TPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASS
Sbjct: 541 TPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASS 600
Query: 578 KLDS 581
KLDS
Sbjct: 601 KLDS 604
>gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo
sapiens]
Length = 576
Score = 1002 bits (2591), Expect = 0.0
Identities = 502/584 (85%), Positives = 514/584 (88%), Gaps = 11/584 (1%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGS---VRGC 237
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT + +L R
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITALLELTELLASHNNYARYR 240
Query: 238 PALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGL 297
G G V V + L Q ++ D +H+ + + L+A+ G
Sbjct: 241 RTWAGCAGFRLPVLG-VHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQ- 298
Query: 298 CHSAISRLKDSHAHLSPDSTKLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVE 357
H S +D HL LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVE
Sbjct: 299 -HPPCSANEDL-LHL----LTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVE 352
Query: 358 WAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPP 417
WAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPP
Sbjct: 353 WAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPP 412
Query: 418 RQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGY 477
RQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGY
Sbjct: 413 RQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGY 472
Query: 478 RCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSL 537
RCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSL
Sbjct: 473 RCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSL 532
Query: 538 EPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 581
EPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS
Sbjct: 533 EPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 576
>gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]
Length = 673
Score = 650 bits (1676), Expect = 0.0
Identities = 326/340 (95%), Positives = 328/340 (96%), Gaps = 2/340 (0%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
Query: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
Sbjct: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
Query: 301 AISRLKDSHAHLSPDSTKLSLDLFYTEDEIYELSYAREPR 340
AISRLKDSHAHLSPDSTK L+L TE +YAR R
Sbjct: 301 AISRLKDSHAHLSPDSTKALLEL--TELLASHNNYARYRR 338
Score = 570 bits (1470), Expect = e-162
Identities = 263/263 (100%), Positives = 263/263 (100%)
Query: 319 LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL 378
LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL
Sbjct: 411 LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL 470
Query: 379 VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA 438
VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA
Sbjct: 471 VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA 530
Query: 439 ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 498
ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC
Sbjct: 531 ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 590
Query: 499 KKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPS 558
KKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPS
Sbjct: 591 KKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPS 650
Query: 559 WETDTVPCPVMDPPSTASSKLDS 581
WETDTVPCPVMDPPSTASSKLDS
Sbjct: 651 WETDTVPCPVMDPPSTASSKLDS 673
>gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo
sapiens]
Length = 659
Score = 610 bits (1573), Expect = e-174
Identities = 312/340 (91%), Positives = 314/340 (92%), Gaps = 16/340 (4%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDL---------- 170
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
PGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
Sbjct: 171 ----PGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 226
Query: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
Sbjct: 227 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 286
Query: 301 AISRLKDSHAHLSPDSTKLSLDLFYTEDEIYELSYAREPR 340
AISRLKDSHAHLSPDSTK L+L TE +YAR R
Sbjct: 287 AISRLKDSHAHLSPDSTKALLEL--TELLASHNNYARYRR 324
Score = 570 bits (1470), Expect = e-162
Identities = 263/263 (100%), Positives = 263/263 (100%)
Query: 319 LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL 378
LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL
Sbjct: 397 LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL 456
Query: 379 VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA 438
VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA
Sbjct: 457 VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA 516
Query: 439 ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 498
ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC
Sbjct: 517 ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 576
Query: 499 KKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPS 558
KKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPS
Sbjct: 577 KKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPS 636
Query: 559 WETDTVPCPVMDPPSTASSKLDS 581
WETDTVPCPVMDPPSTASSKLDS
Sbjct: 637 WETDTVPCPVMDPPSTASSKLDS 659
>gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo
sapiens]
Length = 484
Score = 570 bits (1470), Expect = e-162
Identities = 263/263 (100%), Positives = 263/263 (100%)
Query: 319 LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL 378
LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL
Sbjct: 222 LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL 281
Query: 379 VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA 438
VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA
Sbjct: 282 VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA 341
Query: 439 ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 498
ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC
Sbjct: 342 ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 401
Query: 499 KKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPS 558
KKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPS
Sbjct: 402 KKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPS 461
Query: 559 WETDTVPCPVMDPPSTASSKLDS 581
WETDTVPCPVMDPPSTASSKLDS
Sbjct: 462 WETDTVPCPVMDPPSTASSKLDS 484
Score = 454 bits (1168), Expect = e-127
Identities = 221/221 (100%), Positives = 221/221 (100%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 221
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 221
>gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo
sapiens]
Length = 639
Score = 570 bits (1470), Expect = e-162
Identities = 263/263 (100%), Positives = 263/263 (100%)
Query: 319 LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL 378
LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL
Sbjct: 377 LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL 436
Query: 379 VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA 438
VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA
Sbjct: 437 VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA 496
Query: 439 ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 498
ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC
Sbjct: 497 ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 556
Query: 499 KKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPS 558
KKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPS
Sbjct: 557 KKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPS 616
Query: 559 WETDTVPCPVMDPPSTASSKLDS 581
WETDTVPCPVMDPPSTASSKLDS
Sbjct: 617 WETDTVPCPVMDPPSTASSKLDS 639
Score = 565 bits (1455), Expect = e-161
Identities = 292/340 (85%), Positives = 294/340 (86%), Gaps = 36/340 (10%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT------------------- 221
Query: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
VMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
Sbjct: 222 ---------------VMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 266
Query: 301 AISRLKDSHAHLSPDSTKLSLDLFYTEDEIYELSYAREPR 340
AISRLKDSHAHLSPDSTK L+L TE +YAR R
Sbjct: 267 AISRLKDSHAHLSPDSTKALLEL--TELLASHNNYARYRR 304
>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
sapiens]
Length = 762
Score = 234 bits (596), Expect = 2e-61
Identities = 124/286 (43%), Positives = 180/286 (62%), Gaps = 1/286 (0%)
Query: 34 PSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVL 93
PS I++ ++LG L++G S D+L++ CIQSFD+ G+LC + +L ++L MH V+
Sbjct: 39 PSLAHITQFRMMVSLGHLAKGA-SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVI 97
Query: 94 PSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATV 153
SA+L +++T Y+ A L+IC+ VRYW+ + D L + + F V
Sbjct: 98 SSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELV 157
Query: 154 AREGNSAQRRLGDSSDLLSPGGPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLE 213
+G RL D++ + + KKRKVSLLFDHLE EL++HLTYLE
Sbjct: 158 KAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLE 217
Query: 214 FRSFQAITPQDLRSYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDK 273
F+SF+ I+ D ++Y++ V+ P +E S+ L N +S+WVQ+MVLSRP P RA+V K
Sbjct: 218 FKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIK 277
Query: 274 FIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKL 319
FI VAQ+LHQLQNFNTLMAV GGLCHS+ISRLK++ +H+ + K+
Sbjct: 278 FIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKV 323
Score = 176 bits (447), Expect = 4e-44
Identities = 93/192 (48%), Positives = 116/192 (60%), Gaps = 40/192 (20%)
Query: 319 LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL 378
LSLDL+YTEDEIYELSYAREPR ++
Sbjct: 415 LSLDLYYTEDEIYELSYAREPRNHRA---------------------------------- 440
Query: 379 VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA 438
SVFKNYD + G ISQE+FE+++ +FPF+ + + G SR+E+T Y +RAS+
Sbjct: 441 -PSVFKNYDHDQDGYISQEEFEKIAASFPFSFCVMD---KDREGLISRDEITAYFMRASS 496
Query: 439 ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 498
I SKLGL F H F E T+ KPTFCD+C+GFLWGV KQGYRC++CG+ CHK C+D V EC
Sbjct: 497 IYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFEC 556
Query: 499 KKRPGAKGDAGP 510
KKR AK P
Sbjct: 557 KKR--AKNPVAP 566
>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
sapiens]
Length = 797
Score = 234 bits (596), Expect = 2e-61
Identities = 124/286 (43%), Positives = 180/286 (62%), Gaps = 1/286 (0%)
Query: 34 PSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVL 93
PS I++ ++LG L++G S D+L++ CIQSFD+ G+LC + +L ++L MH V+
Sbjct: 39 PSLAHITQFRMMVSLGHLAKGA-SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVI 97
Query: 94 PSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATV 153
SA+L +++T Y+ A L+IC+ VRYW+ + D L + + F V
Sbjct: 98 SSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELV 157
Query: 154 AREGNSAQRRLGDSSDLLSPGGPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLE 213
+G RL D++ + + KKRKVSLLFDHLE EL++HLTYLE
Sbjct: 158 KAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLE 217
Query: 214 FRSFQAITPQDLRSYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDK 273
F+SF+ I+ D ++Y++ V+ P +E S+ L N +S+WVQ+MVLSRP P RA+V K
Sbjct: 218 FKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIK 277
Query: 274 FIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKL 319
FI VAQ+LHQLQNFNTLMAV GGLCHS+ISRLK++ +H+ + K+
Sbjct: 278 FIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKV 323
Score = 234 bits (596), Expect = 2e-61
Identities = 110/192 (57%), Positives = 143/192 (74%), Gaps = 5/192 (2%)
Query: 319 LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL 378
LSLDL+YTEDEIYELSYAREPR ++ P +P P+VV+WA GV+PKPD T+ +HV+++
Sbjct: 415 LSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRM 474
Query: 379 VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA 438
V+SVFKNYD + G ISQE+FE+++ +FPF+ + + G SR+E+T Y +RAS+
Sbjct: 475 VDSVFKNYDHDQDGYISQEEFEKIAASFPFSFCVMD---KDREGLISRDEITAYFMRASS 531
Query: 439 ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 498
I SKLGL F H F E T+ KPTFCD+C+GFLWGV KQGYRC++CG+ CHK C+D V EC
Sbjct: 532 IYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFEC 591
Query: 499 KKRPGAKGDAGP 510
KKR AK P
Sbjct: 592 KKR--AKNPVAP 601
>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 233 bits (595), Expect = 3e-61
Identities = 126/265 (47%), Positives = 171/265 (64%), Gaps = 2/265 (0%)
Query: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D
Sbjct: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68
Query: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174
+++ CHLVRYW+ P +P+L E I A + +EGN L D D +
Sbjct: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDI-DSVPTY 127
Query: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSV 234
+ +P KKRK+SLLFDHLE ELA+HLTYLE+RSF I QD S+V G
Sbjct: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCT 187
Query: 235 RGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVT 294
P LE + L NSVS+WVQ+M+LS+P QRA V+ F+HVA++L QLQNFNTLMAV
Sbjct: 188 VDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVV 247
Query: 295 GGLCHSAISRLKDSHAHLSPDSTKL 319
GGL HS+ISRLK++H+H+SP++ KL
Sbjct: 248 GGLSHSSISRLKETHSHVSPETIKL 272
Score = 159 bits (401), Expect = 9e-39
Identities = 81/204 (39%), Positives = 119/204 (58%), Gaps = 9/204 (4%)
Query: 319 LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNA------PLVVEWAPGVTPKPDRVTLG 372
+SLD + TEDE+Y+LS REPR KS P SP + P++ EW PK D+ +
Sbjct: 366 VSLDQYQTEDELYQLSLQREPRS-KSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVV 424
Query: 373 RHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGY 432
H+E++VESVF+N+D +G G ISQE+F+ + GNFP+ + G SREE+ Y
Sbjct: 425 EHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLS-AFGDLDQNQDGCISREEMVSY 483
Query: 433 LLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRD 492
LR+S++ + F+H F E +P C C + G+ KQG +CR CG+ CHK C+D
Sbjct: 484 FLRSSSVLGGR-MGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKD 542
Query: 493 QVKVECKKRPGAKGDAGPPGAPVP 516
++ VEC++R + G +P P
Sbjct: 543 RLSVECRRRAQSVSLEGSAPSPSP 566
>gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 233 bits (595), Expect = 3e-61
Identities = 126/265 (47%), Positives = 171/265 (64%), Gaps = 2/265 (0%)
Query: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D
Sbjct: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68
Query: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174
+++ CHLVRYW+ P +P+L E I A + +EGN L D D +
Sbjct: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDI-DSVPTY 127
Query: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSV 234
+ +P KKRK+SLLFDHLE ELA+HLTYLE+RSF I QD S+V G
Sbjct: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCT 187
Query: 235 RGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVT 294
P LE + L NSVS+WVQ+M+LS+P QRA V+ F+HVA++L QLQNFNTLMAV
Sbjct: 188 VDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVV 247
Query: 295 GGLCHSAISRLKDSHAHLSPDSTKL 319
GGL HS+ISRLK++H+H+SP++ KL
Sbjct: 248 GGLSHSSISRLKETHSHVSPETIKL 272
Score = 159 bits (401), Expect = 9e-39
Identities = 81/204 (39%), Positives = 119/204 (58%), Gaps = 9/204 (4%)
Query: 319 LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNA------PLVVEWAPGVTPKPDRVTLG 372
+SLD + TEDE+Y+LS REPR KS P SP + P++ EW PK D+ +
Sbjct: 366 VSLDQYQTEDELYQLSLQREPRS-KSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVV 424
Query: 373 RHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGY 432
H+E++VESVF+N+D +G G ISQE+F+ + GNFP+ + G SREE+ Y
Sbjct: 425 EHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLS-AFGDLDQNQDGCISREEMVSY 483
Query: 433 LLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRD 492
LR+S++ + F+H F E +P C C + G+ KQG +CR CG+ CHK C+D
Sbjct: 484 FLRSSSVLGGR-MGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKD 542
Query: 493 QVKVECKKRPGAKGDAGPPGAPVP 516
++ VEC++R + G +P P
Sbjct: 543 RLSVECRRRAQSVSLEGSAPSPSP 566
>gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 233 bits (595), Expect = 3e-61
Identities = 126/265 (47%), Positives = 171/265 (64%), Gaps = 2/265 (0%)
Query: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D
Sbjct: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68
Query: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174
+++ CHLVRYW+ P +P+L E I A + +EGN L D D +
Sbjct: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDI-DSVPTY 127
Query: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSV 234
+ +P KKRK+SLLFDHLE ELA+HLTYLE+RSF I QD S+V G
Sbjct: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCT 187
Query: 235 RGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVT 294
P LE + L NSVS+WVQ+M+LS+P QRA V+ F+HVA++L QLQNFNTLMAV
Sbjct: 188 VDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVV 247
Query: 295 GGLCHSAISRLKDSHAHLSPDSTKL 319
GGL HS+ISRLK++H+H+SP++ KL
Sbjct: 248 GGLSHSSISRLKETHSHVSPETIKL 272
Score = 159 bits (401), Expect = 9e-39
Identities = 81/204 (39%), Positives = 119/204 (58%), Gaps = 9/204 (4%)
Query: 319 LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNA------PLVVEWAPGVTPKPDRVTLG 372
+SLD + TEDE+Y+LS REPR KS P SP + P++ EW PK D+ +
Sbjct: 366 VSLDQYQTEDELYQLSLQREPRS-KSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVV 424
Query: 373 RHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGY 432
H+E++VESVF+N+D +G G ISQE+F+ + GNFP+ + G SREE+ Y
Sbjct: 425 EHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLS-AFGDLDQNQDGCISREEMVSY 483
Query: 433 LLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRD 492
LR+S++ + F+H F E +P C C + G+ KQG +CR CG+ CHK C+D
Sbjct: 484 FLRSSSVLGGR-MGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKD 542
Query: 493 QVKVECKKRPGAKGDAGPPGAPVP 516
++ VEC++R + G +P P
Sbjct: 543 RLSVECRRRAQSVSLEGSAPSPSP 566
>gi|213385270 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 216 bits (549), Expect = 6e-56
Identities = 119/260 (45%), Positives = 164/260 (63%), Gaps = 3/260 (1%)
Query: 59 DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
DELL CI+ FD G L ++ +VL MH W L S +LA +LL Y+ ATG++ R
Sbjct: 13 DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71
Query: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGP 178
L+IC+ +RYW+++ P + D L + F ++ G L D S + P
Sbjct: 72 LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSI--PSYDWM 129
Query: 179 PLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCP 238
+ KK K LLFDHLE ELA+HLT+LE +SF+ I+ D +SYV+ G + P
Sbjct: 130 RRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNP 189
Query: 239 ALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLC 298
LE S+ L N +S+WVQ+MVLS+P P QRA+V+ KFI+VA++L QL+NFNTLMAV GGL
Sbjct: 190 TLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLS 249
Query: 299 HSAISRLKDSHAHLSPDSTK 318
HS+ISRLK++H+HLS + TK
Sbjct: 250 HSSISRLKETHSHLSSEVTK 269
Score = 197 bits (500), Expect = 3e-50
Identities = 103/228 (45%), Positives = 143/228 (62%), Gaps = 14/228 (6%)
Query: 300 SAISRLKDSHAHLSPDST-----KLSLDLFYTEDEIYELSYAREPRCPKSLPPSPF--NA 352
S + L+++ HL P+ LSLDL++TED+IY+LS EPR KS P SP N
Sbjct: 338 SELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNK 397
Query: 353 PLV-VEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACH 411
P+V +EWA GV PKPD + +H+ +LVESVF+NYD + G ISQEDFE ++ NFPF
Sbjct: 398 PVVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFL-D 456
Query: 412 GLHPPPRQGRGSFSREELTGYLLRA-SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLW 470
+ G S++E+ Y LRA S + K+G F+H F E+T+ KPTFC+ C+GFLW
Sbjct: 457 SFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLW 516
Query: 471 GVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGA----KGDAGPPGAP 514
G+ KQGY+C++CG CHK C+D + + C++ A G PG+P
Sbjct: 517 GIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSP 564
>gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 216 bits (549), Expect = 6e-56
Identities = 119/260 (45%), Positives = 164/260 (63%), Gaps = 3/260 (1%)
Query: 59 DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
DELL CI+ FD G L ++ +VL MH W L S +LA +LL Y+ ATG++ R
Sbjct: 13 DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71
Query: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGP 178
L+IC+ +RYW+++ P + D L + F ++ G L D S + P
Sbjct: 72 LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSI--PSYDWM 129
Query: 179 PLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCP 238
+ KK K LLFDHLE ELA+HLT+LE +SF+ I+ D +SYV+ G + P
Sbjct: 130 RRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNP 189
Query: 239 ALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLC 298
LE S+ L N +S+WVQ+MVLS+P P QRA+V+ KFI+VA++L QL+NFNTLMAV GGL
Sbjct: 190 TLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLS 249
Query: 299 HSAISRLKDSHAHLSPDSTK 318
HS+ISRLK++H+HLS + TK
Sbjct: 250 HSSISRLKETHSHLSSEVTK 269
Score = 197 bits (500), Expect = 3e-50
Identities = 103/228 (45%), Positives = 143/228 (62%), Gaps = 14/228 (6%)
Query: 300 SAISRLKDSHAHLSPDST-----KLSLDLFYTEDEIYELSYAREPRCPKSLPPSPF--NA 352
S + L+++ HL P+ LSLDL++TED+IY+LS EPR KS P SP N
Sbjct: 338 SELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNK 397
Query: 353 PLV-VEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACH 411
P+V +EWA GV PKPD + +H+ +LVESVF+NYD + G ISQEDFE ++ NFPF
Sbjct: 398 PVVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFL-D 456
Query: 412 GLHPPPRQGRGSFSREELTGYLLRA-SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLW 470
+ G S++E+ Y LRA S + K+G F+H F E+T+ KPTFC+ C+GFLW
Sbjct: 457 SFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLW 516
Query: 471 GVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGA----KGDAGPPGAP 514
G+ KQGY+C++CG CHK C+D + + C++ A G PG+P
Sbjct: 517 GIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSP 564
>gi|7662334 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 2 [Homo sapiens]
Length = 689
Score = 216 bits (549), Expect = 6e-56
Identities = 119/260 (45%), Positives = 164/260 (63%), Gaps = 3/260 (1%)
Query: 59 DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
DELL CI+ FD G L ++ +VL MH W L S +LA +LL Y+ ATG++ R
Sbjct: 13 DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71
Query: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGP 178
L+IC+ +RYW+++ P + D L + F ++ G L D S + P
Sbjct: 72 LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSI--PSYDWM 129
Query: 179 PLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCP 238
+ KK K LLFDHLE ELA+HLT+LE +SF+ I+ D +SYV+ G + P
Sbjct: 130 RRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNP 189
Query: 239 ALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLC 298
LE S+ L N +S+WVQ+MVLS+P P QRA+V+ KFI+VA++L QL+NFNTLMAV GGL
Sbjct: 190 TLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLS 249
Query: 299 HSAISRLKDSHAHLSPDSTK 318
HS+ISRLK++H+HLS + TK
Sbjct: 250 HSSISRLKETHSHLSSEVTK 269
Score = 193 bits (490), Expect = 4e-49
Identities = 103/228 (45%), Positives = 143/228 (62%), Gaps = 15/228 (6%)
Query: 300 SAISRLKDSHAHLSPDST-----KLSLDLFYTEDEIYELSYAREPRCPKSLPPSPF--NA 352
S + L+++ HL P+ LSLDL++TED+IY+LS EPR KS P SP N
Sbjct: 338 SELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKS-PTSPTTPNK 396
Query: 353 PLV-VEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACH 411
P+V +EWA GV PKPD + +H+ +LVESVF+NYD + G ISQEDFE ++ NFPF
Sbjct: 397 PVVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFL-D 455
Query: 412 GLHPPPRQGRGSFSREELTGYLLRA-SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLW 470
+ G S++E+ Y LRA S + K+G F+H F E+T+ KPTFC+ C+GFLW
Sbjct: 456 SFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLW 515
Query: 471 GVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGA----KGDAGPPGAP 514
G+ KQGY+C++CG CHK C+D + + C++ A G PG+P
Sbjct: 516 GIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSP 563
>gi|110611226 UNC13 (C. elegans)-like [Homo sapiens]
Length = 1591
Score = 70.1 bits (170), Expect = 5e-12
Identities = 31/87 (35%), Positives = 46/87 (52%), Gaps = 2/87 (2%)
Query: 421 RGSFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYR 478
R S EEL ++ + + A+ + H F T PT+C C G LWG+ +QG R
Sbjct: 448 RTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMR 507
Query: 479 CRECGLCCHKHCRDQVKVECKKRPGAK 505
C ECG+ CH+ C+D + +C +R K
Sbjct: 508 CSECGVKCHEKCQDLLNADCLQRAAEK 534
>gi|122937514 unc-13 homolog C [Homo sapiens]
Length = 2214
Score = 69.3 bits (168), Expect = 9e-12
Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 2/87 (2%)
Query: 421 RGSFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYR 478
R S + EEL ++ + + A+ + H F T PT+C C G LWG+ +QG +
Sbjct: 1068 RTSLNNEELKMHVFKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMK 1127
Query: 479 CRECGLCCHKHCRDQVKVECKKRPGAK 505
C ECG+ CH+ C+D + +C +R K
Sbjct: 1128 CLECGVKCHEKCQDLLNADCLQRAAEK 1154
>gi|122937247 unc-13 homolog A [Homo sapiens]
Length = 1791
Score = 68.9 bits (167), Expect = 1e-11
Identities = 29/85 (34%), Positives = 46/85 (54%), Gaps = 2/85 (2%)
Query: 423 SFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCR 480
+ + EEL ++ + + A+ + H F T PT+C C G LWG+ +QG RC
Sbjct: 614 TLNNEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCT 673
Query: 481 ECGLCCHKHCRDQVKVECKKRPGAK 505
ECG+ CH+ C+D + +C +R K
Sbjct: 674 ECGVKCHEKCQDLLNADCLQRAAEK 698
>gi|5031689 protein kinase D3 [Homo sapiens]
Length = 890
Score = 66.6 bits (161), Expect = 6e-11
Identities = 43/131 (32%), Positives = 60/131 (45%), Gaps = 14/131 (10%)
Query: 449 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC---KKRPGAK 505
HT + +++ PTFCD C LWG+ +QG +C CGL HK C ++ C +KR +
Sbjct: 155 HTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSN 214
Query: 506 GDAGPPGAPVPSTPAP-HASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTV 564
PG VP P + + SEE+H + EP +W S P W V
Sbjct: 215 VSLPGPGLSVPRPLQPEYVALPSEESHVHQ---EPSKRIP---SW----SGRPIWMEKMV 264
Query: 565 PCPVMDPPSTA 575
C V P + A
Sbjct: 265 MCRVKVPHTFA 275
Score = 51.2 bits (121), Expect = 3e-06
Identities = 19/50 (38%), Positives = 29/50 (58%)
Query: 449 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 498
HTF ++ +PT C C L G+ +QG +C++C CHK C +V +C
Sbjct: 272 HTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDC 321
>gi|4758532 ral guanine nucleotide dissociation stimulator-like 2
[Homo sapiens]
Length = 777
Score = 65.5 bits (158), Expect = 1e-10
Identities = 84/330 (25%), Positives = 135/330 (40%), Gaps = 51/330 (15%)
Query: 128 WLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGD-SSDLL-------SPGGPGPP 179
WL HPE + + + + R + + + G +A + +G S+DL+ P P P
Sbjct: 166 WLASHPEDFGSEAKGQ--LDRLESFLLQTGYAAGKGVGGGSADLIRNLRSRVDPQAPDLP 223
Query: 180 LPMSSPGLGKKRKVSLLF---DHLETGELAQHLTYLEFRSFQAITPQDLRSYVL-----Q 231
P++ PG +L DHL A+ LT L+ F + P +
Sbjct: 224 KPLALPGDPPADPTDVLVFLADHL-----AEQLTLLDAELFLNLIPSQCLGGLWGHRDRP 278
Query: 232 GSVRGCPALEGSVGLSNSVSRWVQVMVLSR------PG--------PLQRAQVLDKFIHV 277
G CP++ +V N V+ V VL PG P QRA++L+K+I V
Sbjct: 279 GHSHLCPSVRATVTQFNKVAGAVVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRV 338
Query: 278 AQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKL--SLDLFYTEDEIYELS- 334
A+ L+NF+++ AV L S I RL+ + + DS ++ SL ++E++ Y S
Sbjct: 339 AEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSR 398
Query: 335 --YAREPRCPKSLPPSPFNAPLVVEWAPGVTP-----KPDRVTLGRHVEQLVESVFKNYD 387
+E + L P AP GV P D V L + +E+ + N+D
Sbjct: 399 ELLVQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDAASKDELENGYINFD 458
Query: 388 PEGRGTISQEDFERLSGNFPFACHGLHPPP 417
+ + RL C G + P
Sbjct: 459 KRRKEFAVLSELRRLQNE----CRGYNLQP 484
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 63.2 bits (152), Expect = 7e-10
Identities = 24/50 (48%), Positives = 31/50 (62%)
Query: 449 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 498
H F F +PTFC C F+WG+ KQGY+CR+C HK C D+V +C
Sbjct: 160 HEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKC 209
Score = 53.5 bits (127), Expect = 5e-07
Identities = 19/50 (38%), Positives = 28/50 (56%)
Query: 449 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 498
H F ++ PTFC+ C LWG+ +QG +C CG+ H C+ +V C
Sbjct: 232 HRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLC 281
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 62.8 bits (151), Expect = 8e-10
Identities = 36/96 (37%), Positives = 47/96 (48%), Gaps = 10/96 (10%)
Query: 415 PPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTK 474
PPP +G S R G L + + K H F F++PTFC C+ F+WG K
Sbjct: 8 PPPSEGEESTVRFARKGALRQKNVHEVKN-----HKFTARFFKQPTFCSHCTDFIWGFGK 62
Query: 475 QGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGP 510
QG++C+ C HK C + V C PGA D GP
Sbjct: 63 QGFQCQVCCFVVHKRCHEFVTFSC---PGA--DKGP 93
Score = 47.0 bits (110), Expect = 5e-05
Identities = 20/50 (40%), Positives = 25/50 (50%)
Query: 449 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 498
H F T+ PTFCD C L+G+ QG +C C + HK C V C
Sbjct: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC 151
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 62.8 bits (151), Expect = 8e-10
Identities = 36/96 (37%), Positives = 47/96 (48%), Gaps = 10/96 (10%)
Query: 415 PPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTK 474
PPP +G S R G L + + K H F F++PTFC C+ F+WG K
Sbjct: 8 PPPSEGEESTVRFARKGALRQKNVHEVKN-----HKFTARFFKQPTFCSHCTDFIWGFGK 62
Query: 475 QGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGP 510
QG++C+ C HK C + V C PGA D GP
Sbjct: 63 QGFQCQVCCFVVHKRCHEFVTFSC---PGA--DKGP 93
Score = 47.0 bits (110), Expect = 5e-05
Identities = 20/50 (40%), Positives = 25/50 (50%)
Query: 449 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 498
H F T+ PTFCD C L+G+ QG +C C + HK C V C
Sbjct: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC 151
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 62.0 bits (149), Expect = 1e-09
Identities = 23/50 (46%), Positives = 30/50 (60%)
Query: 449 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 498
H F F +PTFC C F+WG+ KQGY+CR+C HK C D++ C
Sbjct: 159 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRC 208
Score = 59.3 bits (142), Expect = 9e-09
Identities = 22/50 (44%), Positives = 29/50 (58%)
Query: 449 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 498
H F + PTFCD C LWG+ KQG +C +CG+ H CR++V C
Sbjct: 231 HRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLC 280
>gi|31377782 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 62.0 bits (149), Expect = 1e-09
Identities = 23/50 (46%), Positives = 30/50 (60%)
Query: 449 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 498
H F F +PTFC C F+WG+ KQGY+CR+C HK C D++ C
Sbjct: 159 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRC 208
Score = 59.3 bits (142), Expect = 9e-09
Identities = 22/50 (44%), Positives = 29/50 (58%)
Query: 449 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 498
H F + PTFCD C LWG+ KQG +C +CG+ H CR++V C
Sbjct: 231 HRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLC 280
>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
Length = 459
Score = 61.2 bits (147), Expect = 2e-09
Identities = 29/82 (35%), Positives = 45/82 (54%), Gaps = 2/82 (2%)
Query: 420 GRGSFSREELTGYLLRASAICSKLGLAF--LHTFHEVTFRKPTFCDSCSGFLWGVTKQGY 477
G+ S + LT + RA+ ++ + +H F TFR P +C+ C+ F+WG+ QG
Sbjct: 175 GQDGVSEKRLTSLVRRATLKENEQIPKYEKIHNFKVHTFRGPHWCEYCANFMWGLIAQGV 234
Query: 478 RCRECGLCCHKHCRDQVKVECK 499
+C +CGL HK C V +CK
Sbjct: 235 KCADCGLNVHKQCSKMVPNDCK 256
>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
Length = 468
Score = 59.7 bits (143), Expect = 7e-09
Identities = 23/51 (45%), Positives = 31/51 (60%)
Query: 449 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECK 499
H F TFR P +C+ C+ F+WG+ QG RC +CGL HK C V +C+
Sbjct: 215 HNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQ 265
>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
Length = 332
Score = 59.7 bits (143), Expect = 7e-09
Identities = 23/51 (45%), Positives = 31/51 (60%)
Query: 449 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECK 499
H F TFR P +C+ C+ F+WG+ QG RC +CGL HK C V +C+
Sbjct: 79 HNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQ 129
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 59.7 bits (143), Expect = 7e-09
Identities = 24/56 (42%), Positives = 33/56 (58%), Gaps = 3/56 (5%)
Query: 449 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGA 504
H F F++PTFC C+ F+WG+ KQG +C+ C H+ C + V EC PGA
Sbjct: 36 HKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFEC---PGA 88
Score = 45.1 bits (105), Expect = 2e-04
Identities = 18/50 (36%), Positives = 25/50 (50%)
Query: 449 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 498
H F ++ PTFCD C L+G+ QG +C C + H+ C V C
Sbjct: 101 HKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLC 150
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 59.3 bits (142), Expect = 9e-09
Identities = 27/62 (43%), Positives = 35/62 (56%), Gaps = 5/62 (8%)
Query: 449 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA 508
H F F++PTFC C+ F+WG KQG++C+ C HK C + V C PGA D
Sbjct: 37 HKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC---PGA--DK 91
Query: 509 GP 510
GP
Sbjct: 92 GP 93
Score = 47.4 bits (111), Expect = 4e-05
Identities = 20/50 (40%), Positives = 25/50 (50%)
Query: 449 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 498
H F T+ PTFCD C L+G+ QG +C C + HK C V C
Sbjct: 102 HKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLC 151
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,204,387
Number of Sequences: 37866
Number of extensions: 1520903
Number of successful extensions: 11934
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 126
Number of HSP's successfully gapped in prelim test: 64
Number of HSP's that attempted gapping in prelim test: 10555
Number of HSP's gapped (non-prelim): 1434
length of query: 581
length of database: 18,247,518
effective HSP length: 108
effective length of query: 473
effective length of database: 14,157,990
effective search space: 6696729270
effective search space used: 6696729270
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.