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Search of human proteins with 224028289
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
(2481 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens] 4909 0.0
gi|164519122 LGN protein [Homo sapiens] 207 8e-53
gi|224548927 G-protein signaling modulator 1 (AGS3-like, C. eleg... 199 4e-50
gi|224548925 G-protein signaling modulator 1 (AGS3-like, C. eleg... 199 4e-50
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] 103 2e-21
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] 103 2e-21
gi|15619013 43 kD receptor-associated protein of the synapse iso... 87 2e-16
gi|34304360 nephrocystin 3 [Homo sapiens] 86 6e-16
gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizi... 85 1e-15
gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens] 82 5e-15
gi|145386551 SH3 domain and tetratricopeptide repeats 1 [Homo sa... 81 1e-14
gi|38045928 43 kD receptor-associated protein of the synapse iso... 77 2e-13
gi|4506921 small glutamine-rich tetratricopeptide [Homo sapiens] 72 7e-12
gi|225735593 RNA polymerase II associated protein 3 isoform 2 [H... 70 3e-11
gi|225735595 RNA polymerase II associated protein 3 isoform 3 [H... 67 2e-10
gi|225735591 RNA polymerase II associated protein 3 isoform 1 [H... 67 2e-10
gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Hom... 66 4e-10
gi|24308141 small glutamine-rich tetratricopeptide repeat (TPR)-... 66 5e-10
gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 65 8e-10
gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 65 1e-09
gi|73747840 LON peptidase N-terminal domain and ring finger 3 is... 65 1e-09
gi|238859655 tetratricopeptide repeat domain 31 [Homo sapiens] 64 1e-09
gi|38488692 SH3 domain and tetratricopeptide repeats 2 [Homo sap... 64 2e-09
gi|5453958 protein phosphatase 5, catalytic subunit [Homo sapiens] 63 4e-09
gi|157785672 tetratricopeptide repeat domain 24 [Homo sapiens] 63 4e-09
gi|27262638 sperm associated antigen 1 [Homo sapiens] 62 7e-09
gi|27262636 sperm associated antigen 1 [Homo sapiens] 62 7e-09
gi|83415184 transmembrane and tetratricopeptide repeat containin... 62 7e-09
gi|90669931 tetratricopeptide repeat domain 12 [Homo sapiens] 59 5e-08
gi|91982772 mucin 17 [Homo sapiens] 59 8e-08
>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
Length = 2481
Score = 4909 bits (12733), Expect = 0.0
Identities = 2481/2481 (100%), Positives = 2481/2481 (100%)
Query: 1 MEQSPPPAPEPTQGPTPARSRRRREPESPPASAPIPLFGADTIGQRSPDGPVLSKAEFVE 60
MEQSPPPAPEPTQGPTPARSRRRREPESPPASAPIPLFGADTIGQRSPDGPVLSKAEFVE
Sbjct: 1 MEQSPPPAPEPTQGPTPARSRRRREPESPPASAPIPLFGADTIGQRSPDGPVLSKAEFVE 60
Query: 61 KVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARL 120
KVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARL
Sbjct: 61 KVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARL 120
Query: 121 LNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLE 180
LNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLE
Sbjct: 121 LNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLE 180
Query: 181 PTYQQLQKMKLDKSPFVVVSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSAL 240
PTYQQLQKMKLDKSPFVVVSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSAL
Sbjct: 181 PTYQQLQKMKLDKSPFVVVSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSAL 240
Query: 241 SSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQ 300
SSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQ
Sbjct: 241 SSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQ 300
Query: 301 LVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNM 360
LVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNM
Sbjct: 301 LVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNM 360
Query: 361 GAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYV 420
GAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYV
Sbjct: 361 GAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYV 420
Query: 421 LELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNL 480
LELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNL
Sbjct: 421 LELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNL 480
Query: 481 GIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQE 540
GIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQE
Sbjct: 481 GIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQE 540
Query: 541 LQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNL 600
LQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNL
Sbjct: 541 LQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNL 600
Query: 601 GNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQD 660
GNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQD
Sbjct: 601 GNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQD 660
Query: 661 LALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNL 720
LALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNL
Sbjct: 661 LALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNL 720
Query: 721 GDIFICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQE 780
GDIFICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQE
Sbjct: 721 GDIFICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQE 780
Query: 781 LEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNM 840
LEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNM
Sbjct: 781 LEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNM 840
Query: 841 GITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYY 900
GITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYY
Sbjct: 841 GITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYY 900
Query: 901 EQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAY 960
EQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAY
Sbjct: 901 EQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAY 960
Query: 961 GELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYH 1020
GELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYH
Sbjct: 961 GELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYH 1020
Query: 1021 QLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSY 1080
QLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSY
Sbjct: 1021 QLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSY 1080
Query: 1081 SSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGNLEEAQHQL 1140
SSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGNLEEAQHQL
Sbjct: 1081 SSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGNLEEAQHQL 1140
Query: 1141 YRASALFETIRHEAQLSTDYKLSLFDLQTSSYQALQRVLVSLGHHDEALAVAERGRTRAF 1200
YRASALFETIRHEAQLSTDYKLSLFDLQTSSYQALQRVLVSLGHHDEALAVAERGRTRAF
Sbjct: 1141 YRASALFETIRHEAQLSTDYKLSLFDLQTSSYQALQRVLVSLGHHDEALAVAERGRTRAF 1200
Query: 1201 ADLLVERQTGQQDSDPYSPVTIDQILEMVNGQRGLVLYYSLAAGYLYSWLLAPGAGIVKF 1260
ADLLVERQTGQQDSDPYSPVTIDQILEMVNGQRGLVLYYSLAAGYLYSWLLAPGAGIVKF
Sbjct: 1201 ADLLVERQTGQQDSDPYSPVTIDQILEMVNGQRGLVLYYSLAAGYLYSWLLAPGAGIVKF 1260
Query: 1261 HEHYLGENTVENSSDFQASSSVTLPTATGSALEQHIASVREALGVESHYSRACASSETES 1320
HEHYLGENTVENSSDFQASSSVTLPTATGSALEQHIASVREALGVESHYSRACASSETES
Sbjct: 1261 HEHYLGENTVENSSDFQASSSVTLPTATGSALEQHIASVREALGVESHYSRACASSETES 1320
Query: 1321 EAGDIMDQQFEEMNNKLNSVTDPTGFLRMVRRNNLFNRSCQSMTSLFSNTVSPTQDGTSS 1380
EAGDIMDQQFEEMNNKLNSVTDPTGFLRMVRRNNLFNRSCQSMTSLFSNTVSPTQDGTSS
Sbjct: 1321 EAGDIMDQQFEEMNNKLNSVTDPTGFLRMVRRNNLFNRSCQSMTSLFSNTVSPTQDGTSS 1380
Query: 1381 LPRRQSSFAKPPLRALYDLLIAPMEGGLMHSSGPVGRHRQLILVLEGELYLIPFALLKGS 1440
LPRRQSSFAKPPLRALYDLLIAPMEGGLMHSSGPVGRHRQLILVLEGELYLIPFALLKGS
Sbjct: 1381 LPRRQSSFAKPPLRALYDLLIAPMEGGLMHSSGPVGRHRQLILVLEGELYLIPFALLKGS 1440
Query: 1441 SSNEYLYERFGLLAVPSIRSLSVQSKSHLRKNPPTYSSSTSMAAVIGNPKLPSAVMDRWL 1500
SSNEYLYERFGLLAVPSIRSLSVQSKSHLRKNPPTYSSSTSMAAVIGNPKLPSAVMDRWL
Sbjct: 1441 SSNEYLYERFGLLAVPSIRSLSVQSKSHLRKNPPTYSSSTSMAAVIGNPKLPSAVMDRWL 1500
Query: 1501 WGPMPSAEEEAYMVSELLGCQPLVGSVATKERVMSALTQAECVHFATHISWKLSALVLTP 1560
WGPMPSAEEEAYMVSELLGCQPLVGSVATKERVMSALTQAECVHFATHISWKLSALVLTP
Sbjct: 1501 WGPMPSAEEEAYMVSELLGCQPLVGSVATKERVMSALTQAECVHFATHISWKLSALVLTP 1560
Query: 1561 SMDGNPASSKSSFGHPYTIPESLRVQDDASDGESISDCPPLQELLLTAADVLDLQLPVKL 1620
SMDGNPASSKSSFGHPYTIPESLRVQDDASDGESISDCPPLQELLLTAADVLDLQLPVKL
Sbjct: 1561 SMDGNPASSKSSFGHPYTIPESLRVQDDASDGESISDCPPLQELLLTAADVLDLQLPVKL 1620
Query: 1621 VVLGSSQESNSKVTADGVIALTRAFLAAGAQCVLVSLWPVPVAASKMFIHAFYSSLLNGL 1680
VVLGSSQESNSKVTADGVIALTRAFLAAGAQCVLVSLWPVPVAASKMFIHAFYSSLLNGL
Sbjct: 1621 VVLGSSQESNSKVTADGVIALTRAFLAAGAQCVLVSLWPVPVAASKMFIHAFYSSLLNGL 1680
Query: 1681 KASAALGEAMKVVQSSKAFSHPSNWAGFMLIGSDVKLNSPSSLIGQALTEILQHPERARD 1740
KASAALGEAMKVVQSSKAFSHPSNWAGFMLIGSDVKLNSPSSLIGQALTEILQHPERARD
Sbjct: 1681 KASAALGEAMKVVQSSKAFSHPSNWAGFMLIGSDVKLNSPSSLIGQALTEILQHPERARD 1740
Query: 1741 ALRVLLHLVEKSLQRIQNGQRNAMYTSQQSVENKVGGIPGWQALLTAVGFRLDPPTSGLP 1800
ALRVLLHLVEKSLQRIQNGQRNAMYTSQQSVENKVGGIPGWQALLTAVGFRLDPPTSGLP
Sbjct: 1741 ALRVLLHLVEKSLQRIQNGQRNAMYTSQQSVENKVGGIPGWQALLTAVGFRLDPPTSGLP 1800
Query: 1801 AAVFFPTSDPGDRLQQCSSTLQSLLGLPNPALQALCKLITASETGEQLISRAVKNMVGML 1860
AAVFFPTSDPGDRLQQCSSTLQSLLGLPNPALQALCKLITASETGEQLISRAVKNMVGML
Sbjct: 1801 AAVFFPTSDPGDRLQQCSSTLQSLLGLPNPALQALCKLITASETGEQLISRAVKNMVGML 1860
Query: 1861 HQVLVQLQAGEKEQDLASAPIQVSISVQLWRLPGCHEFLAALGFDLCEVGQEEVILKTGK 1920
HQVLVQLQAGEKEQDLASAPIQVSISVQLWRLPGCHEFLAALGFDLCEVGQEEVILKTGK
Sbjct: 1861 HQVLVQLQAGEKEQDLASAPIQVSISVQLWRLPGCHEFLAALGFDLCEVGQEEVILKTGK 1920
Query: 1921 QANRRTVHFALQSLLSLFDSTELPKRLSLDSSSSLESLASAQSVSNALPLGYQQPPFSPT 1980
QANRRTVHFALQSLLSLFDSTELPKRLSLDSSSSLESLASAQSVSNALPLGYQQPPFSPT
Sbjct: 1921 QANRRTVHFALQSLLSLFDSTELPKRLSLDSSSSLESLASAQSVSNALPLGYQQPPFSPT 1980
Query: 1981 GADSIASDAISVYSLSSIASSMSFVSKPEGGSEGGGPGGRQDHDRSKNAYLQRSTLPRSQ 2040
GADSIASDAISVYSLSSIASSMSFVSKPEGGSEGGGPGGRQDHDRSKNAYLQRSTLPRSQ
Sbjct: 1981 GADSIASDAISVYSLSSIASSMSFVSKPEGGSEGGGPGGRQDHDRSKNAYLQRSTLPRSQ 2040
Query: 2041 LPPQTRPAGNKDEEEYEGFSIISNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVSSK 2100
LPPQTRPAGNKDEEEYEGFSIISNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVSSK
Sbjct: 2041 LPPQTRPAGNKDEEEYEGFSIISNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVSSK 2100
Query: 2101 GSISTPNSPVKMTLIPSPNSPFQKVGKLASSDTGESDQSSTETDSTVKSQEESNPKLDPQ 2160
GSISTPNSPVKMTLIPSPNSPFQKVGKLASSDTGESDQSSTETDSTVKSQEESNPKLDPQ
Sbjct: 2101 GSISTPNSPVKMTLIPSPNSPFQKVGKLASSDTGESDQSSTETDSTVKSQEESNPKLDPQ 2160
Query: 2161 ELAQKILEETQSHLIAVERLQRSGGQVSKSNNPEDGVQAPSSTAVFRASETSAFSRPVLS 2220
ELAQKILEETQSHLIAVERLQRSGGQVSKSNNPEDGVQAPSSTAVFRASETSAFSRPVLS
Sbjct: 2161 ELAQKILEETQSHLIAVERLQRSGGQVSKSNNPEDGVQAPSSTAVFRASETSAFSRPVLS 2220
Query: 2221 HQKSQPSPVTVKPKPPARSSSLPKVSSGYSSPTTSEMSIKDSPSQHSGRPSPGCDSQTSQ 2280
HQKSQPSPVTVKPKPPARSSSLPKVSSGYSSPTTSEMSIKDSPSQHSGRPSPGCDSQTSQ
Sbjct: 2221 HQKSQPSPVTVKPKPPARSSSLPKVSSGYSSPTTSEMSIKDSPSQHSGRPSPGCDSQTSQ 2280
Query: 2281 LDQPLFKLKYPSSPYSAHISKSPRNMSPSSGHQSPAGSAPSPALSYSSAGSARSSPADAP 2340
LDQPLFKLKYPSSPYSAHISKSPRNMSPSSGHQSPAGSAPSPALSYSSAGSARSSPADAP
Sbjct: 2281 LDQPLFKLKYPSSPYSAHISKSPRNMSPSSGHQSPAGSAPSPALSYSSAGSARSSPADAP 2340
Query: 2341 DIDKLKMAAIDEKVQAVHNLKMFWQSTPQHSTGPMKIFRGAPGTMTSKRDVLSLLNLSPR 2400
DIDKLKMAAIDEKVQAVHNLKMFWQSTPQHSTGPMKIFRGAPGTMTSKRDVLSLLNLSPR
Sbjct: 2341 DIDKLKMAAIDEKVQAVHNLKMFWQSTPQHSTGPMKIFRGAPGTMTSKRDVLSLLNLSPR 2400
Query: 2401 HNKKEEGVDKLELKELSLQQHDGAPPKAPPNGHWRTETTSLGSLPLPAGPPATAPARPLR 2460
HNKKEEGVDKLELKELSLQQHDGAPPKAPPNGHWRTETTSLGSLPLPAGPPATAPARPLR
Sbjct: 2401 HNKKEEGVDKLELKELSLQQHDGAPPKAPPNGHWRTETTSLGSLPLPAGPPATAPARPLR 2460
Query: 2461 LPSGNGYKFLSPGRFFPSSKC 2481
LPSGNGYKFLSPGRFFPSSKC
Sbjct: 2461 LPSGNGYKFLSPGRFFPSSKC 2481
>gi|164519122 LGN protein [Homo sapiens]
Length = 684
Score = 207 bits (528), Expect = 8e-53
Identities = 120/351 (34%), Positives = 198/351 (56%), Gaps = 20/351 (5%)
Query: 199 VSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQ 258
+++ G+ L +G A V EAA+++GT LK +++S L +AY+ L + K+ Y
Sbjct: 27 LALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAKALEYHH 86
Query: 259 QDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALS 318
DL +A+T+GDQ GE +A GNLG+ GN+ EA+ + L ++ +L D+ + AL
Sbjct: 87 HDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALY 146
Query: 319 SLGHVYTA------------IGDYPN--------ALASHKQCVLLAKQSKDELSEARELG 358
+LG+VY A +G++P A+ +++ + L D ++ R G
Sbjct: 147 NLGNVYHAKGKSFGCPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTALGDRAAQGRAFG 206
Query: 359 NMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHN 418
N+G + +G+F +AV HEQ L IAK+ G+K E RAYSNLG+AY + F+ A Y+
Sbjct: 207 NLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYK 266
Query: 419 YVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASS 478
L LA++L ++A+E ++ LG+ +QD E+A YH + L IA++L DR EGRA
Sbjct: 267 KTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELNDRIGEGRACW 326
Query: 479 NLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGM 529
+LG + G++D A+ + HL I++E+ D + + A N+ + LG+
Sbjct: 327 SLGNAYTALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSDLQMVLGL 377
Score = 181 bits (460), Expect = 6e-45
Identities = 116/382 (30%), Positives = 192/382 (50%), Gaps = 30/382 (7%)
Query: 353 EARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDK 412
E L G + FE AVQ + LK + YS LG+AY Y ++ K
Sbjct: 30 EGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAI---------YSQLGNAYFYLHDYAK 80
Query: 413 AMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAA 472
A+ YH++ L LA+ + ++ E +A LG+ + + + + A ++ L I+ +L D+
Sbjct: 81 ALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVG 140
Query: 473 EGRASSNLGIIHQMKGD--------------------YDTALKLHKTHLCIAQELSDYAA 512
E RA NLG ++ KG A+ ++ +L + L D AA
Sbjct: 141 EARALYNLGNVYHAKGKSFGCPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTALGDRAA 200
Query: 513 QGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDR 572
QGRA+GN+GN + LG + AV H Q L I+ E D+A++ + NL AY LG +
Sbjct: 201 QGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFET 260
Query: 573 ALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEG 632
A ++Y+ L +AR+L+D EA++ +LGN + +Y +A Y+ ++L +A +L D G
Sbjct: 261 ASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELNDRIG 320
Query: 633 EGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLG-LAFKALLNFS 691
EG+ C +LG A+ LGN+ +A+ + E+ L +++++ DK + A NL L L++S
Sbjct: 321 EGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSDLQMVLGLSYS 380
Query: 692 KAEECQKYLLSLAQSLNNSQAK 713
+ SLN + K
Sbjct: 381 TNNSIMSENTEIDSSLNGVRPK 402
Score = 179 bits (453), Expect = 4e-44
Identities = 108/312 (34%), Positives = 169/312 (54%), Gaps = 20/312 (6%)
Query: 517 YGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQH 576
Y +GNAY L Y +A++YH +L ++ + D+ +A GNL + LG D A+
Sbjct: 65 YSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVC 124
Query: 577 YQNHLNIARELRDIQSEARALSNLGNFHCSRG-------------------EYVQAA-PY 616
Q HL+I+REL D EARAL NLGN + ++G + +QAA +
Sbjct: 125 CQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFGCPGPQDVGEFPEEVRDALQAAVDF 184
Query: 617 YEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKA 676
YE+ L L L D +G+ NLG HY LGN+++AV +EQ L +AK+ DK ++ +A
Sbjct: 185 YEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRA 244
Query: 677 YCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKF 736
Y NLG A+ L F A E K L LA+ L + + ++ +LG+ + +D AI +
Sbjct: 245 YSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDY 304
Query: 737 YEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRA 796
+ + L +A ++ DR E A +LG AY + +D+A+ + + LE+ +E+ D GE A
Sbjct: 305 HLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSGELTA 364
Query: 797 HGHLAAVYMALG 808
+L+ + M LG
Sbjct: 365 RLNLSDLQMVLG 376
Score = 174 bits (440), Expect = 1e-42
Identities = 113/407 (27%), Positives = 200/407 (49%), Gaps = 39/407 (9%)
Query: 725 ICKK-DINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEV 783
+CK D + F+E + + +D + ++ Y+ LG AY + Y KAL YH +L +
Sbjct: 34 LCKSGDCRAGVSFFEAAVQVG--TEDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTL 91
Query: 784 YQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGIT 843
+ + D GE +A G+L LG + A C + LD+ ++L D EA+ N+G
Sbjct: 92 ARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLG-- 149
Query: 844 KMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYG-----NLGDCYEALGD-YEEAI 897
NV +G+++G ++G+ E + D + A+
Sbjct: 150 ----NVYHA-----------------------KGKSFGCPGPQDVGEFPEEVRDALQAAV 182
Query: 898 KYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKA 957
+YE+ LS+ +L Q +A+ LGN H +G+ + A++ E+RL++A E G+ +
Sbjct: 183 DFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAER 242
Query: 958 QAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTAL 1017
+AY LG+ + LG +E A ++ L +AR +KDRA+E+ + LG Y + +Y+ A+
Sbjct: 243 RAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAI 302
Query: 1018 QYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKT 1077
YH L IA+E N+ +GRA +LG Y +LG ++A+ + E+HL I+ ++ D + +
Sbjct: 303 DYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSGEL 362
Query: 1078 VSYSSLGRTHHAL-QNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGL 1123
+ +L L +YS + E + L + RH +
Sbjct: 363 TARLNLSDLQMVLGLSYSTNNSIMSENTEIDSSLNGVRPKLGRRHSM 409
Score = 156 bits (395), Expect = 2e-37
Identities = 98/347 (28%), Positives = 180/347 (51%), Gaps = 25/347 (7%)
Query: 605 CSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALA 664
C G+ ++E +++ + D++ + LG A++ L +Y +A++Y+ DL LA
Sbjct: 35 CKSGDCRAGVSFFEAAVQVGTE--DLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLA 92
Query: 665 KDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIF 724
+ + D+L +AKA NLG K L NF +A C + L +++ LN+ + RAL NLG+++
Sbjct: 93 RTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVY 152
Query: 725 ICKKD--------------------INGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAY 764
K + A+ FYE+ L L + DR + A+ LG +
Sbjct: 153 HAKGKSFGCPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTALGDRAAQGRAFGNLGNTH 212
Query: 765 RMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLG 824
++ + A+ H Q L + +E D E RA+ +L Y+ LG++ A + Y++ L L
Sbjct: 213 YLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLA 272
Query: 825 QKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLG 884
++LKD ++EAQ ++G T + E+AI Y + LA+ Q+L+ + GRA +LG
Sbjct: 273 RQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELNDR---IGEGRACWSLG 329
Query: 885 DCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMG 931
+ Y ALG++++A+ + E++L +++ + + A L + +G
Sbjct: 330 NAYTALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSDLQMVLG 376
Score = 140 bits (353), Expect = 2e-32
Identities = 87/290 (30%), Positives = 145/290 (50%), Gaps = 20/290 (6%)
Query: 869 GNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHR 928
G E + Y LG+ Y L DY +A++Y+ L++A+++ +AKA LGN +
Sbjct: 54 GTEDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLK 113
Query: 929 AMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGN---------------- 972
+G+ +A+VC ++ L ++ EL + +A+A LG+++ G
Sbjct: 114 VLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFGCPGPQDVGEFPEE 173
Query: 973 ----YEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQIAE 1028
+ A+ E L++ + DRA + A LG + +G + A+ H+ L IA+
Sbjct: 174 VRDALQAAVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAK 233
Query: 1029 ETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHH 1088
E + + RAY NLG Y LG FE A Y ++ L +A Q+ D A + S SLG T+
Sbjct: 234 EFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYT 293
Query: 1089 ALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGNLEEAQH 1138
LQ+Y +A+ Y + L +A++L R E + LG + A GN ++A H
Sbjct: 294 LLQDYEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMH 343
Score = 127 bits (320), Expect = 1e-28
Identities = 99/368 (26%), Positives = 170/368 (46%), Gaps = 49/368 (13%)
Query: 884 GDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKR 943
GDC + +E A++ + L ++ Y LGN + + +AL
Sbjct: 38 GDCRAGVSFFEAAVQVGTEDLKTLSAI---------YSQLGNAYFYLHDYAKALEYHHHD 88
Query: 944 LVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGL 1003
L +A +G+ +A+A G LG+ LGN+++AI C +R L+I+R++ D+ E+ A L
Sbjct: 89 LTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNL 148
Query: 1004 GGVY------------QQMGEY--------DTALQYHQLDLQIAEETNNPTCQGRAYGNL 1043
G VY Q +GE+ A+ +++ +L + + QGRA+GNL
Sbjct: 149 GNVYHAKGKSFGCPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTALGDRAAQGRAFGNL 208
Query: 1044 GLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEG 1103
G T+ LG F AV+ EQ L IA + D AA+ +YS+LG + L + A Y ++
Sbjct: 209 GNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKT 268
Query: 1104 LRLAEQLGRREDEAKIRHGLGLSLWASGNLEEAQHQLYRASALFETIRHEAQLSTDYKLS 1163
L LA QL R EA+ + LG + + E+A + A+ + +
Sbjct: 269 LLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELNDRIG-------- 320
Query: 1164 LFDLQTSSYQALQRVLVSLGHHDEALAVAERGRTRAFADLLVERQTGQQDSDPYSPVTID 1223
+ + +L +LG+HD+A+ AE+ L + R+ G + + + + +
Sbjct: 321 ----EGRACWSLGNAYTALGNHDQAMHFAEK-------HLEISREVGDKSGELTARLNLS 369
Query: 1224 QILEMVNG 1231
L+MV G
Sbjct: 370 D-LQMVLG 376
Score = 115 bits (289), Expect = 4e-25
Identities = 109/446 (24%), Positives = 192/446 (43%), Gaps = 26/446 (5%)
Query: 55 KAEFVEKVRQSNQACHDGDFHTAIVLYNEALAVDPQNC----ILYSNRSAAYMKIQQYDK 110
+A +E + + C GD + + A+ V ++ +YS AY + Y K
Sbjct: 21 EASCLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAK 80
Query: 111 ALD----DAIKARLLNPKW--PKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLV 164
AL+ D AR + + KA G L+ LG +A+ L + L V
Sbjct: 81 ALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHL-DISRELNDKV 139
Query: 165 GMVEAAMKSPMRDSLEPTYQQLQKMKLDKSPFVVVSVVGQELLTAGHHGASVVVLEAALK 224
G A +L Y K P V +E+ A +L
Sbjct: 140 GEARALY------NLGNVYHAKGKSFGCPGP-QDVGEFPEEVRDALQAAVDFYEENLSLV 192
Query: 225 IGTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAF 284
+G F L + ++ LGN + +Q L +AK GD+ E RA+ NLG+A+
Sbjct: 193 TALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAY 252
Query: 285 FSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLA 344
G + A ++ L+LA +LKDR + + SLG+ YT + DY A+ H + + +A
Sbjct: 253 IFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIA 312
Query: 345 KQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAY 404
++ D + E R ++G Y A+G+ + A+ E+HL+I++++G+K E A NL
Sbjct: 313 QELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSD-- 370
Query: 405 HYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIA 464
+ + S +N ++ E+ +R G H+ M+++E K E+
Sbjct: 371 -LQMVLGLSYSTNNSIMSENTEIDSSLNGVRPKLGRRHS---MENMELMKLTPEKVQNWN 426
Query: 465 EDL--KDRAAEGRASSNLGIIHQMKG 488
++ K + + S+ L ++++KG
Sbjct: 427 SEILAKQKPLIAKPSAKLLFVNRLKG 452
>gi|224548927 G-protein signaling modulator 1 (AGS3-like, C.
elegans) isoform a [Homo sapiens]
Length = 675
Score = 199 bits (505), Expect = 4e-50
Identities = 119/356 (33%), Positives = 193/356 (54%), Gaps = 19/356 (5%)
Query: 308 KDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAM 367
+D + S+ S LG+ Y + ++ AL HK +LLA+ D + EA+ GN+G +
Sbjct: 60 EDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVL 119
Query: 368 GDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQEL 427
G F+ A C ++HL IA++ G+K EARA N+G+ YH + K +S++
Sbjct: 120 GRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAK---GKQLSWN---------- 166
Query: 428 MEKAIEMRAYAGLGHAARCMQD-LERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQM 486
A GH +++ L +A +++E+ L + ++L DRAA+GRA NLG H +
Sbjct: 167 -----AANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYL 221
Query: 487 KGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISME 546
G++ A HK L IA+E D AA+ RAY N+GNA+ LG +D A +Y+++ LQ+S +
Sbjct: 222 LGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQ 281
Query: 547 VNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCS 606
+ D+A +A +L Y L ++RA +++ HL IA+EL D E RA +LGN + S
Sbjct: 282 LRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVS 341
Query: 607 RGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLA 662
G QA + +++L+++ ++ D GE N+ LG + DLA
Sbjct: 342 MGRPAQALTFAKKHLQISQEIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDLA 397
Score = 189 bits (480), Expect = 3e-47
Identities = 117/353 (33%), Positives = 186/353 (52%), Gaps = 23/353 (6%)
Query: 199 VSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQ 258
+++ G+ L AG V EAA+++GT LK +++S L +AY+ L ++ Y +
Sbjct: 31 LALEGERLCKAGDFKTGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHK 90
Query: 259 QDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALS 318
DL +A+T+GD+ GE +A GNLG+ G + EA + L +A + D+ + AL
Sbjct: 91 HDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALY 150
Query: 319 SLGHVYTAIG-------------------DYPNALAS----HKQCVLLAKQSKDELSEAR 355
++G+VY A G D L +++ + L K+ D ++ R
Sbjct: 151 NIGNVYHAKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGR 210
Query: 356 ELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMS 415
GN+G + +G+F A H++ L IAK+ G+K E RAYSNLG+A+ + FD A
Sbjct: 211 AYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAE 270
Query: 416 YHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGR 475
Y+ L+L+++L ++A+E +A LG+ +QD ERA +YH + L IA++L DR EGR
Sbjct: 271 YYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGR 330
Query: 476 ASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALG 528
A +LG + G AL K HL I+QE+ D + A N+ LG
Sbjct: 331 ACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVAQLQLVLG 383
Score = 174 bits (441), Expect = 1e-42
Identities = 107/347 (30%), Positives = 179/347 (51%), Gaps = 25/347 (7%)
Query: 488 GDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEV 547
GD+ T + + + + E D Y +GNAY L + +A++YH+ +L ++ +
Sbjct: 42 GDFKTGVAFFEAAVQVGTE--DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTI 99
Query: 548 NDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSR 607
DR +A GNL + LG D A Q HL+IA+E D EARAL N+GN + ++
Sbjct: 100 GDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAK 159
Query: 608 GEYV-----------------------QAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAH 644
G+ + +A+ +YE+ L L +L D +G+ NLG H
Sbjct: 160 GKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTH 219
Query: 645 YCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLA 704
Y LGN+ EA ++++ LA+AK+ DK ++ +AY NLG A L F A E K L L+
Sbjct: 220 YLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLS 279
Query: 705 QSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAY 764
+ L + + +A +LG+ + +D A +++ + L +A ++ DR E A +LG AY
Sbjct: 280 RQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAY 339
Query: 765 RMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYT 811
+ + +AL + + L++ QE+ D GE A ++A + + LG+ T
Sbjct: 340 VSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVAQLQLVLGRLT 386
Score = 154 bits (388), Expect = 1e-36
Identities = 103/350 (29%), Positives = 181/350 (51%), Gaps = 25/350 (7%)
Query: 725 ICKK-DINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEV 783
+CK D + F+E + + +D + ++ Y+ LG AY ++++ +AL YH +L +
Sbjct: 38 LCKAGDFKTGVAFFEAAVQVG--TEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLL 95
Query: 784 YQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGIT 843
+ + D GE +A G+L LG++ A C + L + Q+ D EA+ N+G
Sbjct: 96 ARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIG-- 153
Query: 844 KMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLG-DCYEALGDYEEAIKYYEQ 902
NV A +QLS N + + + G+L D E L +A ++YE+
Sbjct: 154 ----NVYH----------AKGKQLSWNAA--NATQDPGHLPPDVRETLC---KASEFYER 194
Query: 903 YLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGE 962
LS+ + L Q +AY LGN H +G+ +A ++RL +A E G+ + +AY
Sbjct: 195 NLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSN 254
Query: 963 LGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQL 1022
LG+ H LG ++ A ++ L ++R ++D+A+E+ A LG Y + +Y+ A +YH
Sbjct: 255 LGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLR 314
Query: 1023 DLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMND 1072
L IA+E + +GRA +LG Y S+G +A+ + ++HL I+ ++ D
Sbjct: 315 HLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGD 364
Score = 144 bits (364), Expect = 8e-34
Identities = 89/352 (25%), Positives = 176/352 (50%), Gaps = 28/352 (7%)
Query: 605 CSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALA 664
C G++ ++E +++ + D++ + LG A++ L + A++Y++ DL LA
Sbjct: 39 CKAGDFKTGVAFFEAAVQVGTE--DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLA 96
Query: 665 KDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIF 724
+ + D++ +AKA NLG K L F +A C + LS+AQ + + RAL N+G+++
Sbjct: 97 RTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVY 156
Query: 725 ICK-----------------------KDINGAIKFYEQQLGLAHQVKDRRLEASAYAALG 761
K + + A +FYE+ L L ++ DR + AY LG
Sbjct: 157 HAKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLG 216
Query: 762 TAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQL 821
+ ++ + +A +H + L + +E D E RA+ +L ++ LG++ +A + Y++ L
Sbjct: 217 NTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTL 276
Query: 822 DLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYG 881
L ++L+D ++EAQ ++G T + E A Y + L + Q+L+ + GRA
Sbjct: 277 QLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADR---VGEGRACW 333
Query: 882 NLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSL 933
+LG+ Y ++G +A+ + +++L ++Q + + A + +G L
Sbjct: 334 SLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVAQLQLVLGRL 385
Score = 130 bits (327), Expect = 2e-29
Identities = 85/336 (25%), Positives = 163/336 (48%), Gaps = 28/336 (8%)
Query: 808 GKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQL 867
G + +E + +G + D + +Y +G + A+ Y + L + + +
Sbjct: 42 GDFKTGVAFFEAAVQVGTE--DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTI 99
Query: 868 SGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGH 927
+ +A GNLG+ + LG ++EA +++LS+AQ +A+A +GN +
Sbjct: 100 GDR---MGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVY 156
Query: 928 RAMG-----------------------SLQQALVCFEKRLVVAHELGEAFNKAQAYGELG 964
A G +L +A +E+ L + ELG+ + +AYG LG
Sbjct: 157 HAKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLG 216
Query: 965 SLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDL 1024
+ H LGN+ +A + + +L IA++ D+A E A LG + +G +D A +Y++ L
Sbjct: 217 NTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTL 276
Query: 1025 QIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLG 1084
Q++ + + + +A +LG TY L +ERA Y +HL IA ++ D + + SLG
Sbjct: 277 QLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLG 336
Query: 1085 RTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIR 1120
+ ++ +QA+ + ++ L++++++G R E R
Sbjct: 337 NAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTAR 372
Score = 124 bits (310), Expect = 2e-27
Identities = 79/287 (27%), Positives = 137/287 (47%), Gaps = 30/287 (10%)
Query: 869 GNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHR 928
G E + Y LG+ Y L ++ A++Y++ L +A+++ +AKA LGN +
Sbjct: 58 GTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLK 117
Query: 929 AMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYE-------------- 974
+G +A VC ++ L +A E G+ +A+A +G+++ G
Sbjct: 118 VLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHL 177
Query: 975 ---------QAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQ 1025
+A ER L++ +++ DRA + A LG + +G + A +H+ L
Sbjct: 178 PPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLA 237
Query: 1026 IAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGR 1085
IA+E + + RAY NLG + LG F+ A Y ++ L ++ Q+ D A + + SLG
Sbjct: 238 IAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGN 297
Query: 1086 THHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGN 1132
T+ LQ+Y +A Y L +A++L R E G + W+ GN
Sbjct: 298 TYTLLQDYERAAEYHLRHLLIAQELADRVGE-------GRACWSLGN 337
Score = 119 bits (297), Expect = 5e-26
Identities = 83/328 (25%), Positives = 156/328 (47%), Gaps = 26/328 (7%)
Query: 720 LGDIFICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQ 779
LG+ + K+ A+++++ L LA + DR EA A LG +++ ++D+A +
Sbjct: 72 LGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQR 131
Query: 780 ELEVYQELSDLPGECRAHGHLAAVYMALGKYTM-----------------------AFKC 816
L + QE D GE RA ++ VY A GK A +
Sbjct: 132 HLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPDVRETLCKASEF 191
Query: 817 YEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDR 876
YE L L ++L D + + + YGN+G T + EA + +++LA+ ++ +
Sbjct: 192 YERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAA---E 248
Query: 877 GRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQA 936
RAY NLG+ + LG ++ A +YY++ L +++ L +A+A LGN + + ++A
Sbjct: 249 RRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERA 308
Query: 937 LVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALE 996
+ L++A EL + + +A LG+ + +G QA++ ++ L I++++ DR E
Sbjct: 309 AEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGE 368
Query: 997 SDAACGLGGVYQQMGEYDTALQYHQLDL 1024
A + + +G + + DL
Sbjct: 369 LTARMNVAQLQLVLGRLTSPAASEKPDL 396
Score = 97.1 bits (240), Expect = 2e-19
Identities = 75/298 (25%), Positives = 141/298 (47%), Gaps = 27/298 (9%)
Query: 891 GDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHEL 950
GD++ + ++E + V ++ + Y LGN + + +AL + L++A +
Sbjct: 42 GDFKTGVAFFEAAVQVGTE--DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTI 99
Query: 951 GEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQM 1010
G+ +A+A G LG+ LG +++A C +R L+IA++ D+ E+ A +G VY
Sbjct: 100 GDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAK 159
Query: 1011 GEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQM 1070
G+ QL A T +P G+L T +A + E++LS+ ++
Sbjct: 160 GK--------QLSWNAANATQDP-------GHLPPDVRE--TLCKASEFYERNLSLVKEL 202
Query: 1071 NDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWAS 1130
D AA+ +Y +LG TH+ L N+++A + +E L +A++ G + E + LG +
Sbjct: 203 GDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFL 262
Query: 1131 GNLEEAQHQLYRASALFETIRHEA-------QLSTDYKLSLFDLQTSSYQALQRVLVS 1181
G + A + L +R +A L Y L L D + ++ L+ +L++
Sbjct: 263 GRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTL-LQDYERAAEYHLRHLLIA 319
Score = 50.1 bits (118), Expect = 3e-05
Identities = 32/105 (30%), Positives = 55/105 (52%), Gaps = 7/105 (6%)
Query: 241 SSAYWSLGNT-------EKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREA 293
+ A +SLGNT E++ Y + L +A+ L D+ GE RA +LG+A+ S G +A
Sbjct: 289 AQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQA 348
Query: 294 LTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHK 338
LT + L ++ ++ DR +A ++ + +G + AS K
Sbjct: 349 LTFAKKHLQISQEIGDRHGELTARMNVAQLQLVLGRLTSPAASEK 393
>gi|224548925 G-protein signaling modulator 1 (AGS3-like, C.
elegans) isoform b [Homo sapiens]
Length = 457
Score = 199 bits (505), Expect = 4e-50
Identities = 119/356 (33%), Positives = 193/356 (54%), Gaps = 19/356 (5%)
Query: 308 KDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAM 367
+D + S+ S LG+ Y + ++ AL HK +LLA+ D + EA+ GN+G +
Sbjct: 60 EDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVL 119
Query: 368 GDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQEL 427
G F+ A C ++HL IA++ G+K EARA N+G+ YH + K +S++
Sbjct: 120 GRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAK---GKQLSWN---------- 166
Query: 428 MEKAIEMRAYAGLGHAARCMQD-LERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQM 486
A GH +++ L +A +++E+ L + ++L DRAA+GRA NLG H +
Sbjct: 167 -----AANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYL 221
Query: 487 KGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISME 546
G++ A HK L IA+E D AA+ RAY N+GNA+ LG +D A +Y+++ LQ+S +
Sbjct: 222 LGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQ 281
Query: 547 VNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCS 606
+ D+A +A +L Y L ++RA +++ HL IA+EL D E RA +LGN + S
Sbjct: 282 LRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVS 341
Query: 607 RGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLA 662
G QA + +++L+++ ++ D GE N+ LG + DLA
Sbjct: 342 MGRPAQALTFAKKHLQISQEIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDLA 397
Score = 189 bits (480), Expect = 3e-47
Identities = 117/353 (33%), Positives = 186/353 (52%), Gaps = 23/353 (6%)
Query: 199 VSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQ 258
+++ G+ L AG V EAA+++GT LK +++S L +AY+ L ++ Y +
Sbjct: 31 LALEGERLCKAGDFKTGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHK 90
Query: 259 QDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALS 318
DL +A+T+GD+ GE +A GNLG+ G + EA + L +A + D+ + AL
Sbjct: 91 HDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALY 150
Query: 319 SLGHVYTAIG-------------------DYPNALAS----HKQCVLLAKQSKDELSEAR 355
++G+VY A G D L +++ + L K+ D ++ R
Sbjct: 151 NIGNVYHAKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGR 210
Query: 356 ELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMS 415
GN+G + +G+F A H++ L IAK+ G+K E RAYSNLG+A+ + FD A
Sbjct: 211 AYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAE 270
Query: 416 YHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGR 475
Y+ L+L+++L ++A+E +A LG+ +QD ERA +YH + L IA++L DR EGR
Sbjct: 271 YYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGR 330
Query: 476 ASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALG 528
A +LG + G AL K HL I+QE+ D + A N+ LG
Sbjct: 331 ACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVAQLQLVLG 383
Score = 174 bits (441), Expect = 1e-42
Identities = 107/347 (30%), Positives = 179/347 (51%), Gaps = 25/347 (7%)
Query: 488 GDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEV 547
GD+ T + + + + E D Y +GNAY L + +A++YH+ +L ++ +
Sbjct: 42 GDFKTGVAFFEAAVQVGTE--DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTI 99
Query: 548 NDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSR 607
DR +A GNL + LG D A Q HL+IA+E D EARAL N+GN + ++
Sbjct: 100 GDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAK 159
Query: 608 GEYV-----------------------QAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAH 644
G+ + +A+ +YE+ L L +L D +G+ NLG H
Sbjct: 160 GKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTH 219
Query: 645 YCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLA 704
Y LGN+ EA ++++ LA+AK+ DK ++ +AY NLG A L F A E K L L+
Sbjct: 220 YLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLS 279
Query: 705 QSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAY 764
+ L + + +A +LG+ + +D A +++ + L +A ++ DR E A +LG AY
Sbjct: 280 RQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAY 339
Query: 765 RMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYT 811
+ + +AL + + L++ QE+ D GE A ++A + + LG+ T
Sbjct: 340 VSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVAQLQLVLGRLT 386
Score = 154 bits (388), Expect = 1e-36
Identities = 103/350 (29%), Positives = 181/350 (51%), Gaps = 25/350 (7%)
Query: 725 ICKK-DINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEV 783
+CK D + F+E + + +D + ++ Y+ LG AY ++++ +AL YH +L +
Sbjct: 38 LCKAGDFKTGVAFFEAAVQVG--TEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLL 95
Query: 784 YQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGIT 843
+ + D GE +A G+L LG++ A C + L + Q+ D EA+ N+G
Sbjct: 96 ARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIG-- 153
Query: 844 KMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLG-DCYEALGDYEEAIKYYEQ 902
NV A +QLS N + + + G+L D E L +A ++YE+
Sbjct: 154 ----NVYH----------AKGKQLSWNAA--NATQDPGHLPPDVRETLC---KASEFYER 194
Query: 903 YLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGE 962
LS+ + L Q +AY LGN H +G+ +A ++RL +A E G+ + +AY
Sbjct: 195 NLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSN 254
Query: 963 LGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQL 1022
LG+ H LG ++ A ++ L ++R ++D+A+E+ A LG Y + +Y+ A +YH
Sbjct: 255 LGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLR 314
Query: 1023 DLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMND 1072
L IA+E + +GRA +LG Y S+G +A+ + ++HL I+ ++ D
Sbjct: 315 HLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGD 364
Score = 147 bits (372), Expect = 1e-34
Identities = 99/356 (27%), Positives = 174/356 (48%), Gaps = 17/356 (4%)
Query: 437 YAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKL 496
Y+ LG+A +++ RA +YH+ L +A + DR E +AS NLG ++ G +D A
Sbjct: 69 YSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVC 128
Query: 497 HKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQAST 556
+ HL IAQE D + RA N+GN Y+A G Q+S A+
Sbjct: 129 CQRHLSIAQEQGDKVGEARALYNIGNVYHAKGK------------QLSWNA---ANATQD 173
Query: 557 HGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPY 616
G+L + +A + Y+ +L++ +EL D ++ RA NLGN H G + +A +
Sbjct: 174 PGHLPPDVRETLC--KASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTF 231
Query: 617 YEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKA 676
+++ L +A + D E + NLG AH LG + A +YY++ L L++ L D+ +A+A
Sbjct: 232 HKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQA 291
Query: 677 YCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKF 736
+LG + L ++ +A E L +AQ L + + RA +LG+ ++ A+ F
Sbjct: 292 CYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTF 351
Query: 737 YEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPG 792
++ L ++ ++ DR E +A + ++ + +L Y+ + G
Sbjct: 352 AKKHLQISQEIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDLAGYEAQGEFQG 407
Score = 144 bits (364), Expect = 8e-34
Identities = 89/352 (25%), Positives = 176/352 (50%), Gaps = 28/352 (7%)
Query: 605 CSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALA 664
C G++ ++E +++ + D++ + LG A++ L + A++Y++ DL LA
Sbjct: 39 CKAGDFKTGVAFFEAAVQVGTE--DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLA 96
Query: 665 KDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIF 724
+ + D++ +AKA NLG K L F +A C + LS+AQ + + RAL N+G+++
Sbjct: 97 RTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVY 156
Query: 725 ICK-----------------------KDINGAIKFYEQQLGLAHQVKDRRLEASAYAALG 761
K + + A +FYE+ L L ++ DR + AY LG
Sbjct: 157 HAKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLG 216
Query: 762 TAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQL 821
+ ++ + +A +H + L + +E D E RA+ +L ++ LG++ +A + Y++ L
Sbjct: 217 NTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTL 276
Query: 822 DLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYG 881
L ++L+D ++EAQ ++G T + E A Y + L + Q+L+ + GRA
Sbjct: 277 QLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADR---VGEGRACW 333
Query: 882 NLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSL 933
+LG+ Y ++G +A+ + +++L ++Q + + A + +G L
Sbjct: 334 SLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVAQLQLVLGRL 385
Score = 130 bits (327), Expect = 2e-29
Identities = 85/336 (25%), Positives = 163/336 (48%), Gaps = 28/336 (8%)
Query: 808 GKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQL 867
G + +E + +G + D + +Y +G + A+ Y + L + + +
Sbjct: 42 GDFKTGVAFFEAAVQVGTE--DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTI 99
Query: 868 SGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGH 927
+ +A GNLG+ + LG ++EA +++LS+AQ +A+A +GN +
Sbjct: 100 GDR---MGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVY 156
Query: 928 RAMG-----------------------SLQQALVCFEKRLVVAHELGEAFNKAQAYGELG 964
A G +L +A +E+ L + ELG+ + +AYG LG
Sbjct: 157 HAKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLG 216
Query: 965 SLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDL 1024
+ H LGN+ +A + + +L IA++ D+A E A LG + +G +D A +Y++ L
Sbjct: 217 NTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTL 276
Query: 1025 QIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLG 1084
Q++ + + + +A +LG TY L +ERA Y +HL IA ++ D + + SLG
Sbjct: 277 QLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLG 336
Query: 1085 RTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIR 1120
+ ++ +QA+ + ++ L++++++G R E R
Sbjct: 337 NAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTAR 372
Score = 124 bits (310), Expect = 2e-27
Identities = 79/287 (27%), Positives = 137/287 (47%), Gaps = 30/287 (10%)
Query: 869 GNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHR 928
G E + Y LG+ Y L ++ A++Y++ L +A+++ +AKA LGN +
Sbjct: 58 GTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLK 117
Query: 929 AMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYE-------------- 974
+G +A VC ++ L +A E G+ +A+A +G+++ G
Sbjct: 118 VLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHL 177
Query: 975 ---------QAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQ 1025
+A ER L++ +++ DRA + A LG + +G + A +H+ L
Sbjct: 178 PPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLA 237
Query: 1026 IAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGR 1085
IA+E + + RAY NLG + LG F+ A Y ++ L ++ Q+ D A + + SLG
Sbjct: 238 IAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGN 297
Query: 1086 THHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGN 1132
T+ LQ+Y +A Y L +A++L R E G + W+ GN
Sbjct: 298 TYTLLQDYERAAEYHLRHLLIAQELADRVGE-------GRACWSLGN 337
Score = 119 bits (297), Expect = 5e-26
Identities = 83/328 (25%), Positives = 156/328 (47%), Gaps = 26/328 (7%)
Query: 720 LGDIFICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQ 779
LG+ + K+ A+++++ L LA + DR EA A LG +++ ++D+A +
Sbjct: 72 LGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQR 131
Query: 780 ELEVYQELSDLPGECRAHGHLAAVYMALGKYTM-----------------------AFKC 816
L + QE D GE RA ++ VY A GK A +
Sbjct: 132 HLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPDVRETLCKASEF 191
Query: 817 YEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDR 876
YE L L ++L D + + + YGN+G T + EA + +++LA+ ++ +
Sbjct: 192 YERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAA---E 248
Query: 877 GRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQA 936
RAY NLG+ + LG ++ A +YY++ L +++ L +A+A LGN + + ++A
Sbjct: 249 RRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERA 308
Query: 937 LVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALE 996
+ L++A EL + + +A LG+ + +G QA++ ++ L I++++ DR E
Sbjct: 309 AEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGE 368
Query: 997 SDAACGLGGVYQQMGEYDTALQYHQLDL 1024
A + + +G + + DL
Sbjct: 369 LTARMNVAQLQLVLGRLTSPAASEKPDL 396
Score = 97.1 bits (240), Expect = 2e-19
Identities = 75/298 (25%), Positives = 141/298 (47%), Gaps = 27/298 (9%)
Query: 891 GDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHEL 950
GD++ + ++E + V ++ + Y LGN + + +AL + L++A +
Sbjct: 42 GDFKTGVAFFEAAVQVGTE--DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTI 99
Query: 951 GEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQM 1010
G+ +A+A G LG+ LG +++A C +R L+IA++ D+ E+ A +G VY
Sbjct: 100 GDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAK 159
Query: 1011 GEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQM 1070
G+ QL A T +P G+L T +A + E++LS+ ++
Sbjct: 160 GK--------QLSWNAANATQDP-------GHLPPDVRE--TLCKASEFYERNLSLVKEL 202
Query: 1071 NDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWAS 1130
D AA+ +Y +LG TH+ L N+++A + +E L +A++ G + E + LG +
Sbjct: 203 GDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFL 262
Query: 1131 GNLEEAQHQLYRASALFETIRHEA-------QLSTDYKLSLFDLQTSSYQALQRVLVS 1181
G + A + L +R +A L Y L L D + ++ L+ +L++
Sbjct: 263 GRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTL-LQDYERAAEYHLRHLLIA 319
Score = 50.1 bits (118), Expect = 3e-05
Identities = 32/105 (30%), Positives = 55/105 (52%), Gaps = 7/105 (6%)
Query: 241 SSAYWSLGNT-------EKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREA 293
+ A +SLGNT E++ Y + L +A+ L D+ GE RA +LG+A+ S G +A
Sbjct: 289 AQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQA 348
Query: 294 LTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHK 338
LT + L ++ ++ DR +A ++ + +G + AS K
Sbjct: 349 LTFAKKHLQISQEIGDRHGELTARMNVAQLQLVLGRLTSPAASEK 393
>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
Length = 1036
Score = 103 bits (258), Expect = 2e-21
Identities = 108/427 (25%), Positives = 172/427 (40%), Gaps = 79/427 (18%)
Query: 594 ARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEA 653
A A SNLGN + RG+ +A +Y LRL PD D G + NL A G+ + A
Sbjct: 79 AEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFID----GYI--NLAAALVAAGDMEGA 132
Query: 654 VKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAK 713
V+ Y L DL+ S +LG KAL +A+ C YL ++ N +
Sbjct: 133 VQAYVSALQYNPDLYCVRS------DLGNLLKALGRLEEAKAC--YLKAIETQPNFAV-- 182
Query: 714 FRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKA 773
A NLG +F + +I AI +E+ + L D AY LG + + +D+A
Sbjct: 183 --AWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLD------AYINLGNVLKEARIFDRA 234
Query: 774 LGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDP--- 830
+ + + L + P HG+LA VY G +A Y ++L D
Sbjct: 235 VAAYLRALSL------SPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCN 288
Query: 831 -------------------------SLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQ 865
A N+ K +EEA+ + + L +
Sbjct: 289 LANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFP 348
Query: 866 QLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGN 925
+ + A+ NL + G +EA+ +Y++ + ++ + A AY +GN
Sbjct: 349 EFAA---------AHSNLASVLQQQGKLQEALMHYKEAIRISPTF------ADAYSNMGN 393
Query: 926 GHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLN 985
+ M +Q AL C+ + A ++ AF A A+ L S+H GN +AI+ L
Sbjct: 394 TLKEMQDVQGALQCYTR----AIQINPAF--ADAHSNLASIHKDSGNIPEAIASYRTALK 447
Query: 986 IARDMKD 992
+ D D
Sbjct: 448 LKPDFPD 454
Score = 95.9 bits (237), Expect = 4e-19
Identities = 113/469 (24%), Positives = 188/469 (40%), Gaps = 108/469 (23%)
Query: 276 AHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREA-ASSALSSLGHVYTAIGDYPNAL 334
A+ NLG+ + +G +EA+ ++RH L L D ++AL + G + A+ Y +AL
Sbjct: 81 AYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSAL 140
Query: 335 ASH-----------------------KQCVLLAKQSKDELSEARELGNMGAVYIAMGD-- 369
+ K C L A +++ + A N+G V+ A G+
Sbjct: 141 QYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVA--WSNLGCVFNAQGEIW 198
Query: 370 -----FENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFD----------KAM 414
FE AV L +LGN +EAR + +AY + +
Sbjct: 199 LAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACV 258
Query: 415 SYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEG 474
Y +++LA + +AIE++ + + + +A LK++
Sbjct: 259 YYEQGLIDLAIDTYRRAIELQPH------------------FPDAYCNLANALKEK---- 296
Query: 475 RASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAV 534
G + + + Y+TAL+L TH A L++ A R GN+ ++AV
Sbjct: 297 ------GSVAEAEDCYNTALRLCPTH---ADSLNNLANIKREQGNI----------EEAV 337
Query: 535 KYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEA 594
+ +R+ L++ E A+ H NLA Q G AL HY+ + I+ D
Sbjct: 338 RLYRKALEVFPEF------AAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFAD----- 386
Query: 595 RALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAV 654
A SN+GN + A Y + +++ P D NL H GN EA+
Sbjct: 387 -AYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHS------NLASIHKDSGNIPEAI 439
Query: 655 KYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSL 703
Y L L D D AYCNL + + +++ +E K L+S+
Sbjct: 440 ASYRTALKLKPDFPD------AYCNLAHCLQIVCDWTDYDERMKKLVSI 482
Score = 87.0 bits (214), Expect = 2e-16
Identities = 111/486 (22%), Positives = 186/486 (38%), Gaps = 71/486 (14%)
Query: 312 AASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFE 371
A S+ L+ L H GD+ A+ + C+ L +Q D L + +++ +
Sbjct: 9 ADSTGLAELAHREYQAGDFE---AAERHCMQLWRQEPDNTGV---LLLLSSIHFQCRRLD 62
Query: 372 NAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKA 431
+ +K L A AYSNLG+ Y R +A+ ++ + L L + ++
Sbjct: 63 RSAHFSTLAIKQNPLL------AEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGY 116
Query: 432 IEM-RAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKD------RAAEGRAS------- 477
I + A G +Q A QY+ + DL + R E +A
Sbjct: 117 INLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIET 176
Query: 478 --------SNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGM 529
SNLG + +G+ A+ + + + D AY N+GN +
Sbjct: 177 QPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLD------AYINLGNVLKEARI 230
Query: 530 YDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRD 589
+D+AV + + L +S + A HGNLA Y G D A+ Y+ + + D
Sbjct: 231 FDRAVAAYLRALSLS------PNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPD 284
Query: 590 IQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGN 649
A NL N +G +A Y LRL P D +NL GN
Sbjct: 285 ------AYCNLANALKEKGSVAEAEDCYNTALRLCPTHADS------LNNLANIKREQGN 332
Query: 650 YQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNN 709
+EAV+ Y + L + + A A+ NL + + + Q+ L+ +++
Sbjct: 333 IEEAVRLYRKALEVFPEF------AAAHSNLASVLQ------QQGKLQEALMHYKEAIRI 380
Query: 710 SQAKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVKDRRLE-ASAYAALGTAYRMIQ 768
S A N+G+ +D+ GA++ Y + + + D AS + G I
Sbjct: 381 SPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIA 440
Query: 769 KYDKAL 774
Y AL
Sbjct: 441 SYRTAL 446
Score = 68.2 bits (165), Expect = 1e-10
Identities = 99/486 (20%), Positives = 182/486 (37%), Gaps = 63/486 (12%)
Query: 50 GPVLSKAEFVEKVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYD 109
G V E + QA GDF A + +P N + S+ + + ++ D
Sbjct: 6 GNVADSTGLAELAHREYQA---GDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLD 62
Query: 110 KALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEA 169
++ + A NP +AY G + G+ +A+ + L P + + + A
Sbjct: 63 RSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAA 122
Query: 170 AMKSPMRDSLEPTYQQLQKMKLDKSPFVVVSVVGQELLTAGH----HGASVVVLEAALKI 225
+ + + Y + ++ + + V S +G L G + +E
Sbjct: 123 LVAAGDMEGAVQAY--VSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNF 180
Query: 226 GTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECR---------- 275
L G VF+A + ++ + EK+ LD LG+ E R
Sbjct: 181 AVAWSNL-GCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYL 239
Query: 276 -----------AHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREA-ASSALSSLGHV 323
HGNL ++ +G A+ +R + L D ++AL G V
Sbjct: 240 RALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSV 299
Query: 324 YTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKI 383
A Y AL + C + A L N+ + G+ E AV+ + + L++
Sbjct: 300 AEAEDCYNTAL---RLCP----------THADSLNNLANIKREQGNIEEAVRLYRKALEV 346
Query: 384 AKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHA 443
E A A+SNL S + +A+ ++ + ++ + AY+ +G+
Sbjct: 347 FP------EFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFAD------AYSNMGNT 394
Query: 444 ARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHLCI 503
+ MQD++ A Q + + + I D A SNL IH+ G+ A+ ++T L +
Sbjct: 395 LKEMQDVQGALQCYTRAIQINPAFAD------AHSNLASIHKDSGNIPEAIASYRTALKL 448
Query: 504 AQELSD 509
+ D
Sbjct: 449 KPDFPD 454
Score = 58.2 bits (139), Expect = 1e-07
Identities = 91/441 (20%), Positives = 166/441 (37%), Gaps = 54/441 (12%)
Query: 72 GDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYFR 131
GD A+ Y AL +P + S+ + + ++A +KA P + A+
Sbjct: 127 GDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSN 186
Query: 132 QGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEPTYQQLQKMKL 191
G G A+ F + DP L + + ++ + D Y L+ + L
Sbjct: 187 LGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAY--LRALSL 244
Query: 192 DKSPFVVVSVVGQELLTAGHHG--ASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGN 249
+ VV HG A V + + + + + + AY +L N
Sbjct: 245 SPNHAVV-------------HGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLAN 291
Query: 250 TEKSTGYMQQDLDVAKTLGDQTGECRAH----GNLGSAFFSKGNYREALTNHRHQLVLAM 305
K G + + D T C H NL + +GN EA+ +R L +
Sbjct: 292 ALKEKGSVAEAEDCYNT---ALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFP 348
Query: 306 KLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYI 365
+ ++A S+L V G AL +K+ + ++ D S NMG
Sbjct: 349 EF------AAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYS------NMGNTLK 396
Query: 366 AMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQ 425
M D + A+QC+ + ++I A A+SNL S + N +A++ + L+L
Sbjct: 397 EMQDVQGALQCYTRAIQINPAF------ADAHSNLASIHKDSGNIPEAIASYRTALKLKP 450
Query: 426 ELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASS---NLGI 482
+ + AY L H C+Q + Y E+ + + D+ + R S + +
Sbjct: 451 DFPD------AYCNLAH---CLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSM 501
Query: 483 IHQMKGDYDTALKLHKTHLCI 503
++ + + A+ +LC+
Sbjct: 502 LYPLSHGFRKAIAERHGNLCL 522
Score = 49.3 bits (116), Expect = 5e-05
Identities = 57/237 (24%), Positives = 95/237 (40%), Gaps = 32/237 (13%)
Query: 827 LKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDC 886
+K L A+ Y N+G ++EAI ++ L + +D Y NL
Sbjct: 72 IKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRL------KPDFID---GYINLAAA 122
Query: 887 YEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVV 946
A GD E A++ Y L L ++ LGN +A+G L++A C+ K +
Sbjct: 123 LVAAGDMEGAVQAYVSALQYNPDLYCVRSD------LGNLLKALGRLEEAKACYLKAIET 176
Query: 947 AHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGV 1006
N A A+ LG + + G AI E+ + + + DA LG V
Sbjct: 177 QP------NFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNF------LDAYINLGNV 224
Query: 1007 YQQMGEYDTALQYHQLDLQIAEETNNPTCQGR---AYGNLGLTYESLGTFERAVVYQ 1060
++ +D A+ + L ++ N+ G Y GL ++ T+ RA+ Q
Sbjct: 225 LKEARIFDRAVAAYLRALSLS--PNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQ 279
Score = 32.0 bits (71), Expect = 7.8
Identities = 37/139 (26%), Positives = 53/139 (38%), Gaps = 26/139 (18%)
Query: 1003 LGGVYQQMGEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQ 1062
L ++ Q D + + L ++ NP AY NLG Y+ G + A+ +
Sbjct: 51 LSSIHFQCRRLDRSAHFSTLAIK-----QNPLL-AEAYSNLGNVYKERGQLQEAIEHYRH 104
Query: 1063 HLSIAAQMND----LAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAK 1118
L + D LAA V + G A+Q Y A+ Y D
Sbjct: 105 ALRLKPDFIDGYINLAAALV---AAGDMEGAVQAYVSALQY-------------NPDLYC 148
Query: 1119 IRHGLGLSLWASGNLEEAQ 1137
+R LG L A G LEEA+
Sbjct: 149 VRSDLGNLLKALGRLEEAK 167
>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
Length = 1046
Score = 103 bits (258), Expect = 2e-21
Identities = 108/427 (25%), Positives = 172/427 (40%), Gaps = 79/427 (18%)
Query: 594 ARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEA 653
A A SNLGN + RG+ +A +Y LRL PD D G + NL A G+ + A
Sbjct: 89 AEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFID----GYI--NLAAALVAAGDMEGA 142
Query: 654 VKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAK 713
V+ Y L DL+ S +LG KAL +A+ C YL ++ N +
Sbjct: 143 VQAYVSALQYNPDLYCVRS------DLGNLLKALGRLEEAKAC--YLKAIETQPNFAV-- 192
Query: 714 FRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKA 773
A NLG +F + +I AI +E+ + L D AY LG + + +D+A
Sbjct: 193 --AWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLD------AYINLGNVLKEARIFDRA 244
Query: 774 LGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDP--- 830
+ + + L + P HG+LA VY G +A Y ++L D
Sbjct: 245 VAAYLRALSL------SPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCN 298
Query: 831 -------------------------SLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQ 865
A N+ K +EEA+ + + L +
Sbjct: 299 LANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFP 358
Query: 866 QLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGN 925
+ + A+ NL + G +EA+ +Y++ + ++ + A AY +GN
Sbjct: 359 EFAA---------AHSNLASVLQQQGKLQEALMHYKEAIRISPTF------ADAYSNMGN 403
Query: 926 GHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLN 985
+ M +Q AL C+ + A ++ AF A A+ L S+H GN +AI+ L
Sbjct: 404 TLKEMQDVQGALQCYTR----AIQINPAF--ADAHSNLASIHKDSGNIPEAIASYRTALK 457
Query: 986 IARDMKD 992
+ D D
Sbjct: 458 LKPDFPD 464
Score = 95.9 bits (237), Expect = 4e-19
Identities = 113/469 (24%), Positives = 188/469 (40%), Gaps = 108/469 (23%)
Query: 276 AHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREA-ASSALSSLGHVYTAIGDYPNAL 334
A+ NLG+ + +G +EA+ ++RH L L D ++AL + G + A+ Y +AL
Sbjct: 91 AYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSAL 150
Query: 335 ASH-----------------------KQCVLLAKQSKDELSEARELGNMGAVYIAMGD-- 369
+ K C L A +++ + A N+G V+ A G+
Sbjct: 151 QYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVA--WSNLGCVFNAQGEIW 208
Query: 370 -----FENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFD----------KAM 414
FE AV L +LGN +EAR + +AY + +
Sbjct: 209 LAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACV 268
Query: 415 SYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEG 474
Y +++LA + +AIE++ + + + +A LK++
Sbjct: 269 YYEQGLIDLAIDTYRRAIELQPH------------------FPDAYCNLANALKEK---- 306
Query: 475 RASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAV 534
G + + + Y+TAL+L TH A L++ A R GN+ ++AV
Sbjct: 307 ------GSVAEAEDCYNTALRLCPTH---ADSLNNLANIKREQGNI----------EEAV 347
Query: 535 KYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEA 594
+ +R+ L++ E A+ H NLA Q G AL HY+ + I+ D
Sbjct: 348 RLYRKALEVFPEF------AAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFAD----- 396
Query: 595 RALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAV 654
A SN+GN + A Y + +++ P D NL H GN EA+
Sbjct: 397 -AYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHS------NLASIHKDSGNIPEAI 449
Query: 655 KYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSL 703
Y L L D D AYCNL + + +++ +E K L+S+
Sbjct: 450 ASYRTALKLKPDFPD------AYCNLAHCLQIVCDWTDYDERMKKLVSI 492
Score = 85.5 bits (210), Expect = 6e-16
Identities = 96/404 (23%), Positives = 157/404 (38%), Gaps = 59/404 (14%)
Query: 394 ARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEM-RAYAGLGHAARCMQDLER 452
A AYSNLG+ Y R +A+ ++ + L L + ++ I + A G +Q
Sbjct: 89 AEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVS 148
Query: 453 AKQYHEQQLGIAEDLKD------RAAEGRAS---------------SNLGIIHQMKGDYD 491
A QY+ + DL + R E +A SNLG + +G+
Sbjct: 149 ALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIW 208
Query: 492 TALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRA 551
A+ + + + D AY N+GN ++D+AV + + L +S
Sbjct: 209 LAIHHFEKAVTLDPNFLD------AYINLGNVLKEARIFDRAVAAYLRALSLS------P 256
Query: 552 SQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYV 611
+ A HGNLA Y G D A+ Y+ + + D A NL N +G
Sbjct: 257 NHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPD------AYCNLANALKEKGSVA 310
Query: 612 QAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKL 671
+A Y LRL P D +NL GN +EAV+ Y + L + +
Sbjct: 311 EAEDCYNTALRLCPTHADS------LNNLANIKREQGNIEEAVRLYRKALEVFPEF---- 360
Query: 672 SQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDIN 731
A A+ NL + + + Q+ L+ +++ S A N+G+ +D+
Sbjct: 361 --AAAHSNLASVLQ------QQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQ 412
Query: 732 GAIKFYEQQLGLAHQVKDRRLE-ASAYAALGTAYRMIQKYDKAL 774
GA++ Y + + + D AS + G I Y AL
Sbjct: 413 GALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTAL 456
Score = 68.2 bits (165), Expect = 1e-10
Identities = 100/488 (20%), Positives = 184/488 (37%), Gaps = 63/488 (12%)
Query: 48 PDGPVLSKAEFVEKVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQ 107
P +LS E + QA GDF A + +P N + S+ + + ++
Sbjct: 14 PTKRMLSFQGLAELAHREYQA---GDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRR 70
Query: 108 YDKALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMV 167
D++ + A NP +AY G + G+ +A+ + L P + + +
Sbjct: 71 LDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLA 130
Query: 168 EAAMKSPMRDSLEPTYQQLQKMKLDKSPFVVVSVVGQELLTAGH----HGASVVVLEAAL 223
A + + + Y + ++ + + V S +G L G + +E
Sbjct: 131 AALVAAGDMEGAVQAY--VSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQP 188
Query: 224 KIGTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECR-------- 275
L G VF+A + ++ + EK+ LD LG+ E R
Sbjct: 189 NFAVAWSNL-GCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAA 247
Query: 276 -------------AHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREA-ASSALSSLG 321
HGNL ++ +G A+ +R + L D ++AL G
Sbjct: 248 YLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKG 307
Query: 322 HVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHL 381
V A Y AL + C + A L N+ + G+ E AV+ + + L
Sbjct: 308 SVAEAEDCYNTAL---RLCP----------THADSLNNLANIKREQGNIEEAVRLYRKAL 354
Query: 382 KIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLG 441
++ E A A+SNL S + +A+ ++ + ++ + AY+ +G
Sbjct: 355 EVFP------EFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFAD------AYSNMG 402
Query: 442 HAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHL 501
+ + MQD++ A Q + + + I D A SNL IH+ G+ A+ ++T L
Sbjct: 403 NTLKEMQDVQGALQCYTRAIQINPAFAD------AHSNLASIHKDSGNIPEAIASYRTAL 456
Query: 502 CIAQELSD 509
+ + D
Sbjct: 457 KLKPDFPD 464
Score = 58.2 bits (139), Expect = 1e-07
Identities = 91/441 (20%), Positives = 166/441 (37%), Gaps = 54/441 (12%)
Query: 72 GDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYFR 131
GD A+ Y AL +P + S+ + + ++A +KA P + A+
Sbjct: 137 GDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSN 196
Query: 132 QGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEPTYQQLQKMKL 191
G G A+ F + DP L + + ++ + D Y L+ + L
Sbjct: 197 LGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAY--LRALSL 254
Query: 192 DKSPFVVVSVVGQELLTAGHHG--ASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGN 249
+ VV HG A V + + + + + + AY +L N
Sbjct: 255 SPNHAVV-------------HGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLAN 301
Query: 250 TEKSTGYMQQDLDVAKTLGDQTGECRAH----GNLGSAFFSKGNYREALTNHRHQLVLAM 305
K G + + D T C H NL + +GN EA+ +R L +
Sbjct: 302 ALKEKGSVAEAEDCYNT---ALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFP 358
Query: 306 KLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYI 365
+ ++A S+L V G AL +K+ + ++ D S NMG
Sbjct: 359 EF------AAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYS------NMGNTLK 406
Query: 366 AMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQ 425
M D + A+QC+ + ++I A A+SNL S + N +A++ + L+L
Sbjct: 407 EMQDVQGALQCYTRAIQINPAF------ADAHSNLASIHKDSGNIPEAIASYRTALKLKP 460
Query: 426 ELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASS---NLGI 482
+ + AY L H C+Q + Y E+ + + D+ + R S + +
Sbjct: 461 DFPD------AYCNLAH---CLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSM 511
Query: 483 IHQMKGDYDTALKLHKTHLCI 503
++ + + A+ +LC+
Sbjct: 512 LYPLSHGFRKAIAERHGNLCL 532
Score = 49.3 bits (116), Expect = 5e-05
Identities = 57/237 (24%), Positives = 95/237 (40%), Gaps = 32/237 (13%)
Query: 827 LKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDC 886
+K L A+ Y N+G ++EAI ++ L + +D Y NL
Sbjct: 82 IKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRL------KPDFID---GYINLAAA 132
Query: 887 YEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVV 946
A GD E A++ Y L L ++ LGN +A+G L++A C+ K +
Sbjct: 133 LVAAGDMEGAVQAYVSALQYNPDLYCVRSD------LGNLLKALGRLEEAKACYLKAIET 186
Query: 947 AHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGV 1006
N A A+ LG + + G AI E+ + + + DA LG V
Sbjct: 187 QP------NFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNF------LDAYINLGNV 234
Query: 1007 YQQMGEYDTALQYHQLDLQIAEETNNPTCQGR---AYGNLGLTYESLGTFERAVVYQ 1060
++ +D A+ + L ++ N+ G Y GL ++ T+ RA+ Q
Sbjct: 235 LKEARIFDRAVAAYLRALSLS--PNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQ 289
Score = 32.7 bits (73), Expect = 4.6
Identities = 48/185 (25%), Positives = 69/185 (37%), Gaps = 34/185 (18%)
Query: 958 QAYGELGSLHSQLGNYEQAISCLERQ-LNIARDMKDRALESDAACGLGGVYQQMGEYDTA 1016
Q EL Q G++E A ER + + R D + L ++ Q D +
Sbjct: 22 QGLAELAHREYQAGDFEAA----ERHCMQLWRQEPDN---TGVLLLLSSIHFQCRRLDRS 74
Query: 1017 LQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMND---- 1072
+ L ++ NP AY NLG Y+ G + A+ + L + D
Sbjct: 75 AHFSTLAIK-----QNPLL-AEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYIN 128
Query: 1073 LAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGN 1132
LAA V + G A+Q Y A+ Y D +R LG L A G
Sbjct: 129 LAAALV---AAGDMEGAVQAYVSALQY-------------NPDLYCVRSDLGNLLKALGR 172
Query: 1133 LEEAQ 1137
LEEA+
Sbjct: 173 LEEAK 177
>gi|15619013 43 kD receptor-associated protein of the synapse isoform
1 [Homo sapiens]
Length = 412
Score = 87.0 bits (214), Expect = 2e-16
Identities = 95/420 (22%), Positives = 170/420 (40%), Gaps = 66/420 (15%)
Query: 629 DMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALL 688
D+ G +V L AH +G Y+E +K+ + A++L D ++Y NL + + L
Sbjct: 38 DLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDADFLLESYLNLARSNEKLC 97
Query: 689 NFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVK 748
F K K L L + +Q + ++G+ F+ A++ +E+ L AH
Sbjct: 98 EFHKTISYCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSVFQKALESFEKALRYAHNND 157
Query: 749 DRRLEASAYAALGTAYRMIQKYDKALGYHTQELEV---YQELSDLPGECRAHGHLAAVYM 805
D LE +LG+ Y ++ Y+KAL + + E+ Y + L + H+A Y
Sbjct: 158 DAMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNNYGKGWSLKYRAMSQYHMAVAYR 217
Query: 806 ALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQ 865
LG+ A +C EE + + + D L+A L +L
Sbjct: 218 LLGRLGSAMECCEESMKIALQHGDRPLQA--------------------------LCLL- 250
Query: 866 QLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGN 925
D + + GD E A Y+ +S+ + Q +A G+
Sbjct: 251 ----------------CFADIHRSRGDLETAFPRYDSAMSIMTEIGNRLGQVQALLGVAK 294
Query: 926 GHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQL- 984
A +L +AL E+ +A E+G ++ + + S++ G L+R+L
Sbjct: 295 CWVARKALDKALDAIERAQDLAEEVGNKLSQLKLHCLSESIYRSKG--------LQRELR 346
Query: 985 -NIARDMKDRALESDAACGLGGVYQQMGEYDTALQ-------YHQLDLQIAEETNNPTCQ 1036
++ R + E++ CGL G + +GE ++ LQ +H LQ + P C+
Sbjct: 347 AHVVR-FHECVEETELYCGLCG--ESIGEKNSRLQALPCSHIFHLRCLQNNGTRSCPNCR 403
Score = 69.7 bits (169), Expect = 3e-11
Identities = 72/330 (21%), Positives = 139/330 (42%), Gaps = 6/330 (1%)
Query: 250 TEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKD 309
TEK+ +Q V + D G R G L +A G Y+E L Q+ A +L+D
Sbjct: 22 TEKA---LQVWTKVLEKSSDLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELED 78
Query: 310 REAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGD 369
+ + +L + ++ ++ K C+ L + +MG ++ +
Sbjct: 79 ADFLLESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSV 138
Query: 370 FENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELME 429
F+ A++ E+ L+ A + + E R +LGS Y ++++KA+ + EL +
Sbjct: 139 FQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNNYGK 198
Query: 430 K-AIEMRAYAG--LGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQM 486
+++ RA + + A R + L A + E+ + IA DR + IH+
Sbjct: 199 GWSLKYRAMSQYHMAVAYRLLGRLGSAMECCEESMKIALQHGDRPLQALCLLCFADIHRS 258
Query: 487 KGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISME 546
+GD +TA + + + I E+ + Q +A + + A D+A+ + ++ E
Sbjct: 259 RGDLETAFPRYDSAMSIMTEIGNRLGQVQALLGVAKCWVARKALDKALDAIERAQDLAEE 318
Query: 547 VNDRASQASTHGNLAVAYQALGAHDRALQH 576
V ++ SQ H Y++ G H
Sbjct: 319 VGNKLSQLKLHCLSESIYRSKGLQRELRAH 348
Score = 63.9 bits (154), Expect = 2e-09
Identities = 78/370 (21%), Positives = 148/370 (40%), Gaps = 56/370 (15%)
Query: 771 DKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDP 830
+KAL T+ LE + SDL G R G L + +G+Y K Q+D ++L+D
Sbjct: 23 EKALQVWTKVLE---KSSDLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDA 79
Query: 831 SLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEAL 890
+ +Y NL E L
Sbjct: 80 DFLLE-------------------------------------------SYLNLARSNEKL 96
Query: 891 GDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHEL 950
++ + I Y + L + + Q + +GN + Q+AL FEK L AH
Sbjct: 97 CEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSVFQKALESFEKALRYAHNN 156
Query: 951 GEAFNKAQAYGELGSLHSQLGNYEQAI--SCLERQL--NIAR--DMKDRALESDAACGLG 1004
+A + + LGS ++Q+ +YE+A+ C +L N + +K RA+ + +
Sbjct: 157 DDAMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNNYGKGWSLKYRAM---SQYHMA 213
Query: 1005 GVYQQMGEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHL 1064
Y+ +G +A++ + ++IA + + Q + S G E A + +
Sbjct: 214 VAYRLLGRLGSAMECCEESMKIALQHGDRPLQALCLLCFADIHRSRGDLETAFPRYDSAM 273
Query: 1065 SIAAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLG 1124
SI ++ + + + + + A + +A+ ++ LAE++G + + K+ H L
Sbjct: 274 SIMTEIGNRLGQVQALLGVAKCWVARKALDKALDAIERAQDLAEEVGNKLSQLKL-HCLS 332
Query: 1125 LSLWASGNLE 1134
S++ S L+
Sbjct: 333 ESIYRSKGLQ 342
Score = 63.5 bits (153), Expect = 2e-09
Identities = 56/309 (18%), Positives = 134/309 (43%), Gaps = 3/309 (0%)
Query: 503 IAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAV 562
+ ++ SD + R G + A++ +G Y + +K+ ++ + E+ D ++ NLA
Sbjct: 32 VLEKSSDLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDADFLLESYLNLAR 91
Query: 563 AYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLR 622
+ + L + + + + L + Q + ++GN + +A +E+ LR
Sbjct: 92 SNEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSVFQKALESFEKALR 151
Query: 623 LAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLS---QAKAYCN 679
A + D E +VC +LG + + +Y++A+ + + L + S +A + +
Sbjct: 152 YAHNNDDAMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNNYGKGWSLKYRAMSQYH 211
Query: 680 LGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQ 739
+ +A++ L A EC + + +A + + L DI + D+ A Y+
Sbjct: 212 MAVAYRLLGRLGSAMECCEESMKIALQHGDRPLQALCLLCFADIHRSRGDLETAFPRYDS 271
Query: 740 QLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGH 799
+ + ++ +R + A + + + DKAL + ++ +E+ + + + H
Sbjct: 272 AMSIMTEIGNRLGQVQALLGVAKCWVARKALDKALDAIERAQDLAEEVGNKLSQLKLHCL 331
Query: 800 LAAVYMALG 808
++Y + G
Sbjct: 332 SESIYRSKG 340
Score = 54.7 bits (130), Expect = 1e-06
Identities = 60/333 (18%), Positives = 128/333 (38%), Gaps = 16/333 (4%)
Query: 687 LLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQ 746
L ++ E+ + + + ++ +FR LG L +KF Q+ A +
Sbjct: 16 LYQSNQTEKALQVWTKVLEKSSDLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARE 75
Query: 747 VKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAA---- 802
++D +Y L + + ++ K + Y L LPG RA L
Sbjct: 76 LEDADFLLESYLNLARSNEKLCEFHKTISYCKTCL-------GLPGT-RAGAQLGGQVSL 127
Query: 803 ----VYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFE 858
++ L + A + +E+ L D LE +V ++G + E+A+ +
Sbjct: 128 SMGNAFLGLSVFQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYEKALFFPC 187
Query: 859 QQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAK 918
+ ++ S+ R + ++ Y LG A++ E+ + +A QA
Sbjct: 188 KAAELVNNYGKGWSLKYRAMSQYHMAVAYRLLGRLGSAMECCEESMKIALQHGDRPLQAL 247
Query: 919 AYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAIS 978
+ HR+ G L+ A ++ + + E+G + QA + ++A+
Sbjct: 248 CLLCFADIHRSRGDLETAFPRYDSAMSIMTEIGNRLGQVQALLGVAKCWVARKALDKALD 307
Query: 979 CLERQLNIARDMKDRALESDAACGLGGVYQQMG 1011
+ER ++A ++ ++ + C +Y+ G
Sbjct: 308 AIERAQDLAEEVGNKLSQLKLHCLSESIYRSKG 340
Score = 52.8 bits (125), Expect = 4e-06
Identities = 52/254 (20%), Positives = 106/254 (41%), Gaps = 6/254 (2%)
Query: 279 NLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASH- 337
++G+AF +++AL + L A D SLG Y + DY AL
Sbjct: 128 SMGNAFLGLSVFQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYEKALFFPC 187
Query: 338 KQCVLLAKQSKDELSEARELG--NMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEAR 395
K L+ K + R + +M Y +G +A++C E+ +KIA G++ +A
Sbjct: 188 KAAELVNNYGKGWSLKYRAMSQYHMAVAYRLLGRLGSAMECCEESMKIALQHGDRPLQAL 247
Query: 396 AYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQ 455
+ R + + A ++ + + E+ + +++A G+ + L++A
Sbjct: 248 CLLCFADIHRSRGDLETAFPRYDSAMSIMTEIGNRLGQVQALLGVAKCWVARKALDKALD 307
Query: 456 YHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLH--KTHLCIAQELSDYAAQ 513
E+ +AE++ ++ ++ + I++ KG L+ H + H C+ +
Sbjct: 308 AIERAQDLAEEVGNKLSQLKLHCLSESIYRSKG-LQRELRAHVVRFHECVEETELYCGLC 366
Query: 514 GRAYGNMGNAYNAL 527
G + G + AL
Sbjct: 367 GESIGEKNSRLQAL 380
Score = 50.4 bits (119), Expect = 2e-05
Identities = 49/230 (21%), Positives = 98/230 (42%), Gaps = 4/230 (1%)
Query: 231 KLRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNY 290
+L G V ++ +A+ L +K+ ++ L A D ECR +LGS + +Y
Sbjct: 120 QLGGQVSLSMGNAFLGLSVFQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDY 179
Query: 291 REALTNHRHQLVLAMKLKDREAASSALSSLGHV---YTAIGDYPNALASHKQCVLLAKQS 347
+AL L + S H+ Y +G +A+ ++ + +A Q
Sbjct: 180 EKALFFPCKAAELVNNYGKGWSLKYRAMSQYHMAVAYRLLGRLGSAMECCEESMKIALQH 239
Query: 348 KDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYR 407
D +A L ++ + GD E A ++ + I ++GN+ + +A + + R
Sbjct: 240 GDRPLQALCLLCFADIHRSRGDLETAFPRYDSAMSIMTEIGNRLGQVQALLGVAKCWVAR 299
Query: 408 RNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYH 457
+ DKA+ +LA+E+ K +++ + L + + L+R + H
Sbjct: 300 KALDKALDAIERAQDLAEEVGNKLSQLKLHC-LSESIYRSKGLQRELRAH 348
Score = 47.0 bits (110), Expect = 2e-04
Identities = 41/199 (20%), Positives = 86/199 (43%), Gaps = 3/199 (1%)
Query: 914 QDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNY 973
QDQ K G ++AL + K L + +L F + G L + HS++G Y
Sbjct: 3 QDQTKQQIEKGLQLYQSNQTEKALQVWTKVLEKSSDLMGRF---RVLGCLVTAHSEMGRY 59
Query: 974 EQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQIAEETNNP 1033
++ + Q++ AR+++D ++ L +++ E+ + Y + L +
Sbjct: 60 KEMLKFAVVQIDTARELEDADFLLESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGA 119
Query: 1034 TCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHHALQNY 1093
G+ ++G + L F++A+ E+ L A +D + SLG + +++Y
Sbjct: 120 QLGGQVSLSMGNAFLGLSVFQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDY 179
Query: 1094 SQAVMYLQEGLRLAEQLGR 1112
+A+ + + L G+
Sbjct: 180 EKALFFPCKAAELVNNYGK 198
>gi|34304360 nephrocystin 3 [Homo sapiens]
Length = 1330
Score = 85.5 bits (210), Expect = 6e-16
Identities = 91/383 (23%), Positives = 170/383 (44%), Gaps = 42/383 (10%)
Query: 317 LSSLGHVYTAIGDYPNALASHKQCVLLAKQS---------KDELSEARELGNMGAVYIAM 367
+S L +Y +G + L Q ++ ++S D A+ L + +VY+
Sbjct: 939 MSCLADLYETLGRFLKDLGLLSQAIVPLQRSLEIRETALDPDHPRVAQSLHQLASVYVQW 998
Query: 368 GDFENAVQCHEQHLKIAKDL--GNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQ 425
F NA Q ++Q L+I+++ + AR L + Y + +++A + ++ Q
Sbjct: 999 KKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQ 1058
Query: 426 ELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQ 485
+ ++K + +A L RA Q E LG KD R + LG+++
Sbjct: 1059 KAIKKKGNLYGFALLRR---------RALQLEELTLG-----KDTPDNARTLNELGVLYY 1104
Query: 486 MKGDYDTALKLHKTHLCIAQEL--SDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQI 543
++ + +TA + K L + + + D+ ++ N+ N YD+A + + + L I
Sbjct: 1105 LQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDI 1164
Query: 544 SMEV--NDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQ------SEAR 595
D S A T +LA+ Y+ +G D+A+ Y+ +A E+R S A
Sbjct: 1165 RRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYE----LAVEIRQKSFGPKHPSVAT 1220
Query: 596 ALSNLGNFHCSRGEYVQAAPYYEQYLRLAPD-LQDMEGE-GKVCHNLGYAHYCLGNYQEA 653
AL NL + ++V+A P YE+ L++ D L M G+ NL Y G++++A
Sbjct: 1221 ALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKA 1280
Query: 654 VKYYEQDLALAKDLHDKLSQAKA 676
+ Y++ + + K+ L KA
Sbjct: 1281 AELYKRAMEI-KEAETSLLGGKA 1302
Score = 65.1 bits (157), Expect = 8e-10
Identities = 85/398 (21%), Positives = 169/398 (42%), Gaps = 46/398 (11%)
Query: 650 YQEAVKYYEQD------LALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLS- 702
Y +++K YE++ ++ DL++ L + +LGL +A++ ++ E ++ L
Sbjct: 922 YFDSLKQYEKNCEGEDNMSCLADLYETLGRFLK--DLGLLSQAIVPLQRSLEIRETALDP 979
Query: 703 ----LAQSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQV--KDRRLEASA 756
+AQSL+ L +++ K A + Y+Q L ++ D A
Sbjct: 980 DHPRVAQSLHQ----------LASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTARE 1029
Query: 757 YAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKC 816
AL T Y+ KY++A + + +++Q+ G L + L
Sbjct: 1030 LEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQL--------- 1080
Query: 817 YEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDR 876
E+L LG KD A+ +G+ N +E A + ++ L M +++ G + D
Sbjct: 1081 --EELTLG---KDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHP-DC 1134
Query: 877 GRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAY--RGLGNGHRAMGSLQ 934
++ NL Y++A + YE+ L + + + AY + L ++ MG L
Sbjct: 1135 AQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLD 1194
Query: 935 QALVCFEKRLVVAHE-LGEAF-NKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKD 992
+A+ +E + + + G + A A L L+SQ+ + +A+ ER L I D
Sbjct: 1195 KAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLG 1254
Query: 993 R--ALESDAACGLGGVYQQMGEYDTALQYHQLDLQIAE 1028
R + L + + G+++ A + ++ ++I E
Sbjct: 1255 RMHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEIKE 1292
Score = 48.5 bits (114), Expect = 8e-05
Identities = 48/209 (22%), Positives = 92/209 (44%), Gaps = 23/209 (11%)
Query: 715 RALGNLGDIFICKKDINGAIKFYEQQLGLAHQV--KDRRLEASAYAALGTAYRMIQKYDK 772
R L LG ++ + ++ A +F ++ L + +V D A + L ++YDK
Sbjct: 1094 RTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYDK 1153
Query: 773 ALGYHTQELEVYQEL--SDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKL--- 827
A + + L++ + D P HLA +Y +GK A YE +++ QK
Sbjct: 1154 AEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGP 1213
Query: 828 KDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCY 887
K PS+ A N+ + M EA+ +E+ L + + GR + +G+
Sbjct: 1214 KHPSV-ATALVNLAVLYSQMKKHVEALPLYERALKIYED--------SLGRMHPRVGETL 1264
Query: 888 EAL-------GDYEEAIKYYEQYLSVAQS 909
+ L GD+E+A + Y++ + + ++
Sbjct: 1265 KNLAVLSYEGGDFEKAAELYKRAMEIKEA 1293
Score = 40.0 bits (92), Expect = 0.029
Identities = 50/228 (21%), Positives = 97/228 (42%), Gaps = 31/228 (13%)
Query: 892 DYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELG 951
+Y +++K YE+ +++ + D Y LG + +G L QA+V ++ L +
Sbjct: 921 EYFDSLKQYEKNCEGEDNMSCLAD---LYETLGRFLKDLGLLSQAIVPLQRSLEIRETAL 977
Query: 952 EAFNK--AQAYGELGSLHSQ---LGN----YEQAISCLERQLNIARDMKDRALESDAACG 1002
+ + AQ+ +L S++ Q GN Y+QA+ E R LE+
Sbjct: 978 DPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTARELEA----- 1032
Query: 1003 LGGVYQQMGEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQ 1062
L +YQ+ +Y+ A + + +I ++ +G YG L +L Q +
Sbjct: 1033 LATLYQKQNKYEQAEHFRKKSFKIHQKAIKK--KGNLYGFALLRRRAL---------QLE 1081
Query: 1063 HLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQL 1110
L++ D A + + LG ++ N A +L+ L + E++
Sbjct: 1082 ELTLGKDTPDNAR---TLNELGVLYYLQNNLETADQFLKRSLEMRERV 1126
Score = 36.2 bits (82), Expect = 0.41
Identities = 50/202 (24%), Positives = 79/202 (39%), Gaps = 26/202 (12%)
Query: 957 AQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESD------AACGLGGVYQQM 1010
A Y LG LG QAI L+R L I ++ AL+ D + L VY Q
Sbjct: 943 ADLYETLGRFLKDLGLLSQAIVPLQRSLEI----RETALDPDHPRVAQSLHQLASVYVQW 998
Query: 1011 GEYDTALQYHQLDLQIAEETNNPT--CQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAA 1068
++ A Q ++ L+I+E R L Y+ +E+A ++++ I
Sbjct: 999 KKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQ 1058
Query: 1069 QMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLW 1128
+ ++ L R ALQ E L L + D A+ + LG+ +
Sbjct: 1059 KAIKKKGNLYGFALLRR--RALQ---------LEELTLGKDT---PDNARTLNELGVLYY 1104
Query: 1129 ASGNLEEAQHQLYRASALFETI 1150
NLE A L R+ + E +
Sbjct: 1105 LQNNLETADQFLKRSLEMRERV 1126
>gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing
protein) [Homo sapiens]
Length = 543
Score = 84.7 bits (208), Expect = 1e-15
Identities = 47/136 (34%), Positives = 67/136 (49%)
Query: 60 EKVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKAR 119
E + N+A G+ A+ Y+EA+ +DP N +LYSNRSAAY K Y KA +D K
Sbjct: 6 ELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTV 65
Query: 120 LLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSL 179
L P W K Y R+ AL++L R +A + GL + + QL G+ + R +
Sbjct: 66 DLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAERKFM 125
Query: 180 EPTYQQLQKMKLDKSP 195
P KL+ P
Sbjct: 126 NPFNMPNLYQKLESDP 141
Score = 57.8 bits (138), Expect = 1e-07
Identities = 30/98 (30%), Positives = 52/98 (53%)
Query: 59 VEKVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKA 118
+E+ + N+ GD+ A+ Y EA+ +P++ LYSNR+A Y K+ ++ AL D +
Sbjct: 361 LEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEEC 420
Query: 119 RLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQD 156
L P + K Y R+ AL+ + + A+ + L D
Sbjct: 421 IQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLD 458
Score = 43.5 bits (101), Expect = 0.003
Identities = 51/230 (22%), Positives = 94/230 (40%), Gaps = 33/230 (14%)
Query: 478 SNLGIIHQMKGDYDTALKLHKTHLCIAQE-LSDYAAQGRAYGNMGNAYNALGMYDQAVKY 536
+N ++ KGDY+ +L + + + +E DY +AY +GN+Y Y A+ +
Sbjct: 263 TNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHF 322
Query: 537 HRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARA 596
+ + L ++ T L QA ++ L+ + I +L A
Sbjct: 323 YNKSL----------AEHRTPDVLKKCQQA----EKILKEQERLAYINPDL------ALE 362
Query: 597 LSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKY 656
N GN +G+Y QA +Y + ++ P + K+ N + L +Q A+K
Sbjct: 363 EKNKGNECFQKGDYPQAMKHYTEAIKRNPK------DAKLYSNRAACYTKLLEFQLALKD 416
Query: 657 YEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQS 706
E+ + L K Y A +A+ +++KA + + L L S
Sbjct: 417 CEECIQLEPTF------IKGYTRKAAALEAMKDYTKAMDVYQKALDLDSS 460
Score = 42.0 bits (97), Expect = 0.008
Identities = 49/226 (21%), Positives = 95/226 (42%), Gaps = 33/226 (14%)
Query: 359 NMGAVYIAMGDFENAVQCHEQHLKIAKD-LGNKREEARAYSNLGSAYHYRRNFDKAMSYH 417
N AVY GD+ + E+ +++ ++ + R+ A+AY+ +G++Y + A+ ++
Sbjct: 264 NQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFY 323
Query: 418 NYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRAS 477
N LA+ ++ +C Q A++ ++Q +A D A E
Sbjct: 324 N--KSLAEHRTPDVLK-----------KCQQ----AEKILKEQERLAYINPDLALE---E 363
Query: 478 SNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYH 537
N G KGDY A+K H T + + + Y N Y L + A+K
Sbjct: 364 KNKGNECFQKGDYPQAMK-HYT-----EAIKRNPKDAKLYSNRAACYTKLLEFQLALKDC 417
Query: 538 RQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNI 583
+ +Q+ + + A A +A+ + +A+ YQ L++
Sbjct: 418 EECIQL------EPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDL 457
Score = 38.1 bits (87), Expect = 0.11
Identities = 36/159 (22%), Positives = 65/159 (40%), Gaps = 34/159 (21%)
Query: 4 SPPPAPEPTQGPTPARSRRRREPESPPASAPIPLFGADTIGQRSPDGPVLSKAEFVEKVR 63
+PPP P P ++E + P +P +K + +++
Sbjct: 198 TPPPPPPP-----------KKETKPEPMEEDLPE----------------NKKQALKEKE 230
Query: 64 QSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQY-------DKALDDAI 116
N A DF TA+ Y++A +DP N +N++A Y + Y +KA++
Sbjct: 231 LGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGR 290
Query: 117 KARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQ 155
+ R + KAY R G + ++ DA+ + LA+
Sbjct: 291 ENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAE 329
Score = 37.0 bits (84), Expect = 0.24
Identities = 66/312 (21%), Positives = 116/312 (37%), Gaps = 46/312 (14%)
Query: 719 NLGDIFICKKDINGAIKFYEQQLGLAHQVK-DRRLEASAYAALGTAYRMIQKYDKALGYH 777
N ++ K D N + E+ + + + + D R A AYA +G +Y +KY A+ ++
Sbjct: 264 NQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFY 323
Query: 778 TQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVY 837
+ L ++ L K A K +EQ L D +LE +
Sbjct: 324 NKSLAEHRTPD-----------------VLKKCQQAEKILKEQERLAYINPDLALEEKNK 366
Query: 838 GNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAI 897
GN K G + Q AM + + Y N CY L +++ A+
Sbjct: 367 GNECFQK----------GDYPQ--AMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLAL 414
Query: 898 KYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKA 957
K E+ + + + K Y AM +A+ ++K L + EA +
Sbjct: 415 KDCEECIQLEPTF------IKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAAD-- 466
Query: 958 QAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTAL 1017
G + Y + S + + D + + + SD A L + +QM + AL
Sbjct: 467 ------GYQRCMMAQYNRHDSPEDVKRRAMADPEVQQIMSDPAMRL--ILEQMQKDPQAL 518
Query: 1018 QYHQLDLQIAEE 1029
H + IA++
Sbjct: 519 SEHLKNPVIAQK 530
Score = 36.2 bits (82), Expect = 0.41
Identities = 67/318 (21%), Positives = 127/318 (39%), Gaps = 58/318 (18%)
Query: 822 DLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAI--------GYFEQQLAMLQQLSGNESV 873
DLG KL+DP + + +G+ +M+ EE + M + L N+
Sbjct: 165 DLGTKLQDPRIMTTLSVLLGVDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQ 224
Query: 874 LDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSV-AQSLNRMQDQAKAYRGLGNGHRAMGS 932
+ + GN D Y+ D++ A+K+Y++ + ++ + +QA Y G+ ++
Sbjct: 225 ALKEKELGN--DAYKK-KDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRE- 280
Query: 933 LQQALVCFEKRLVVAHELGEAFNK-AQAYGELGSLHSQLGNYEQAI-------------- 977
+C EK + V E E + + A+AY +G+ + + Y+ AI
Sbjct: 281 -----LC-EKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPD 334
Query: 978 ---------SCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQIAE 1028
L+ Q +A D ALE G Q G+Y A++++ ++
Sbjct: 335 VLKKCQQAEKILKEQERLAYINPDLALEEK---NKGNECFQKGDYPQAMKHYTEAIK--- 388
Query: 1029 ETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHH 1088
NP + Y N Y L F+ A+ E+ + + Y+
Sbjct: 389 --RNPK-DAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTF------IKGYTRKAAALE 439
Query: 1089 ALQNYSQAVMYLQEGLRL 1106
A+++Y++A+ Q+ L L
Sbjct: 440 AMKDYTKAMDVYQKALDL 457
>gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens]
Length = 1378
Score = 82.4 bits (202), Expect = 5e-15
Identities = 111/499 (22%), Positives = 206/499 (41%), Gaps = 36/499 (7%)
Query: 744 AHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAV 803
A + RR EA+ LG +Y +AL H QEL++ + D G AH +
Sbjct: 17 AQRAGQRREEAALCHQLGELLAGHGRYAEALEQHWQELQLRERADDPLGCAVAHRKIGER 76
Query: 804 YMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNM-------NVMEEAIGY 856
+ Y A + + L+L L++ + + + +G T +++ + + +A
Sbjct: 77 LAEMEDYPAALQHQHQYLELAHSLRNHTELQRAWATIGRTHLDIYDHCQSRDALLQAQAA 136
Query: 857 FEQQLAMLQQ-----LSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLN 911
FE+ LA++ + L+ E R R Y NLG +E+L Y+ + + +A+ +
Sbjct: 137 FEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFESLQQTALCNDYFRKSIFLAEQNH 196
Query: 912 RMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLG 971
+D +A LG H G QA+ C E AH + + F +++ + + LG
Sbjct: 197 LYEDLFRARYNLGTIHWRAGQHSQAMRCLEGARECAHTMRKRFMESECCVVIAQVLQDLG 256
Query: 972 NYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQIAEETN 1031
++ A L++ + + ++ A C Q ++ A+ Q L+ A E
Sbjct: 257 DFLAAKRALKKAYRLG---SQKPVQRAAIC-------QNLQHVLAVVRLQQQLEEA-EGR 305
Query: 1032 NPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAA-KTVSYSSLGRTHHAL 1090
+P LG + G F RA ++ L A ++ A + + + SL T +
Sbjct: 306 DPQGAMVICEQLGDLFSKAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLATTLGDM 365
Query: 1091 QNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGNLEEAQHQLYR--ASALFE 1148
+++ AV + +E LRL + G +EAK + LS +G+ E ++ S +
Sbjct: 366 KDHHGAVRHYEEELRL--RSGNVLEEAKTWLNIALSREEAGDAYELLAPCFQKALSCAQQ 423
Query: 1149 TIRHEAQLSTDYKLSLFDLQTSSYQALQRVL----VSLGHHDEALAVAERGRTRAFADLL 1204
R + Q L L+ +A + +S+ ++ AE A ++ L
Sbjct: 424 AQRPQLQRQVLQHLHTVQLRLQPQEAPETETRLRELSVAEDEDEEEEAEEAAATAESEAL 483
Query: 1205 ----VERQTGQQDSDPYSP 1219
VE G+ D+D +P
Sbjct: 484 EAGEVELSEGEDDTDGLTP 502
Score = 79.7 bits (195), Expect = 3e-14
Identities = 105/445 (23%), Positives = 175/445 (39%), Gaps = 81/445 (18%)
Query: 520 MGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQN 579
+G G Y +A++ H QELQ+ +D A H + + + ALQH
Sbjct: 33 LGELLAGHGRYAEALEQHWQELQLRERADDPLGCAVAHRKIGERLAEMEDYPAALQHQHQ 92
Query: 580 HLNIARELRDIQSEARALSNLGNFHC-------SRGEYVQAAPYYEQYLRLAPDLQDMEG 632
+L +A LR+ RA + +G H SR +QA +E+ L + D E
Sbjct: 93 YLELAHSLRNHTELQRAWATIGRTHLDIYDHCQSRDALLQAQAAFEKSLAIV----DEEL 148
Query: 633 EGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSK 692
EG + G E + + Y NLGL F++L +
Sbjct: 149 EGTLAQ---------GELNE-------------------MRTRLYLNLGLTFESLQQTAL 180
Query: 693 AEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVKDRRL 752
+ + + LA+ + + FRA NLG I + A++ E AH ++ R +
Sbjct: 181 CNDYFRKSIFLAEQNHLYEDLFRARYNLGTIHWRAGQHSQAMRCLEGARECAHTMRKRFM 240
Query: 753 EA-----------------SAYAALGTAYRMIQKYDKALGYHTQELE-------VYQELS 788
E+ +A AL AYR+ + Q L+ + Q+L
Sbjct: 241 ESECCVVIAQVLQDLGDFLAAKRALKKAYRLGSQKPVQRAAICQNLQHVLAVVRLQQQLE 300
Query: 789 DLPGE--------CRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLE-AQVYGN 839
+ G C G L + G + A + Y++QL + L P E A ++ +
Sbjct: 301 EAEGRDPQGAMVICEQLGDL---FSKAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVS 357
Query: 840 MGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGD-YEEAIK 898
+ T +M A+ ++E++L + SGN VL+ + + N+ E GD YE
Sbjct: 358 LATTLGDMKDHHGAVRHYEEELRL---RSGN--VLEEAKTWLNIALSREEAGDAYELLAP 412
Query: 899 YYEQYLSVAQSLNRMQDQAKAYRGL 923
+++ LS AQ R Q Q + + L
Sbjct: 413 CFQKALSCAQQAQRPQLQRQVLQHL 437
Score = 63.9 bits (154), Expect = 2e-09
Identities = 92/424 (21%), Positives = 160/424 (37%), Gaps = 50/424 (11%)
Query: 264 AKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHV 323
A+ G + E LG G Y EAL H +L L + D + A +G
Sbjct: 17 AQRAGQRREEAALCHQLGELLAGHGRYAEALEQHWQELQLRERADDPLGCAVAHRKIGER 76
Query: 324 YTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYI--------------AMGD 369
+ DYP AL Q + LA ++ R +G ++ A
Sbjct: 77 LAEMEDYPAALQHQHQYLELAHSLRNHTELQRAWATIGRTHLDIYDHCQSRDALLQAQAA 136
Query: 370 FENAVQCHEQHLKIAKDLGNKRE-EARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQE-- 426
FE ++ ++ L+ G E R Y NLG + + Y + LA++
Sbjct: 137 FEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFESLQQTALCNDYFRKSIFLAEQNH 196
Query: 427 LMEKAIEMRAYAGLGH--------AARCMQDLERA-----KQYHEQQ-----LGIAEDLK 468
L E R G H A RC++ K++ E + + +DL
Sbjct: 197 LYEDLFRARYNLGTIHWRAGQHSQAMRCLEGARECAHTMRKRFMESECCVVIAQVLQDLG 256
Query: 469 DRAAEGRASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDY--AAQGR-------AYGN 519
D A RA + K A+ + H+ L A+GR
Sbjct: 257 DFLAAKRALKKAYRLGSQKPVQRAAICQNLQHVLAVVRLQQQLEEAEGRDPQGAMVICEQ 316
Query: 520 MGNAYNALGMYDQAVKYHRQELQISMEVNDR--ASQASTHGNLAVAYQALGAHDRALQHY 577
+G+ ++ G + +A + ++++L+ + E+ DR A +A H +LA + H A++HY
Sbjct: 317 LGDLFSKAGDFPRAAEAYQKQLRFA-ELLDRPGAERAIIHVSLATTLGDMKDHHGAVRHY 375
Query: 578 QNHLNIARELRDIQSEARALSNLGNFHCSRGE-YVQAAPYYEQYLRLAPDLQDMEGEGKV 636
+ L + ++ EA+ N+ G+ Y AP +++ L A Q + + +V
Sbjct: 376 EEELRL--RSGNVLEEAKTWLNIALSREEAGDAYELLAPCFQKALSCAQQAQRPQLQRQV 433
Query: 637 CHNL 640
+L
Sbjct: 434 LQHL 437
Score = 63.5 bits (153), Expect = 2e-09
Identities = 58/235 (24%), Positives = 99/235 (42%), Gaps = 15/235 (6%)
Query: 932 SLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMK 991
SL++ L K A G+ +A +LG L + G Y +A+ ++L +
Sbjct: 2 SLERELRQLSKAKAKAQRAGQRREEAALCHQLGELLAGHGRYAEALEQHWQELQLRERAD 61
Query: 992 DRALESDAACGLGGVYQQMGEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTY---- 1047
D + A +G +M +Y ALQ+ L++A N T RA+ +G T+
Sbjct: 62 DPLGCAVAHRKIGERLAEMEDYPAALQHQHQYLELAHSLRNHTELQRAWATIGRTHLDIY 121
Query: 1048 ----------ESLGTFERAVVYQEQHLSIAAQMNDL-AAKTVSYSSLGRTHHALQNYSQA 1096
++ FE+++ ++ L +L +T Y +LG T +LQ +
Sbjct: 122 DHCQSRDALLQAQAAFEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFESLQQTALC 181
Query: 1097 VMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGNLEEAQHQLYRASALFETIR 1151
Y ++ + LAEQ ED + R+ LG W +G +A L A T+R
Sbjct: 182 NDYFRKSIFLAEQNHLYEDLFRARYNLGTIHWRAGQHSQAMRCLEGARECAHTMR 236
Score = 62.0 bits (149), Expect = 7e-09
Identities = 92/445 (20%), Positives = 174/445 (39%), Gaps = 54/445 (12%)
Query: 633 EGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSK 692
E +CH LG G Y EA++ + Q+L L + D L A A+ +G + ++
Sbjct: 26 EAALCHQLGELLAGHGRYAEALEQHWQELQLRERADDPLGCAVAHRKIGERLAEMEDYPA 85
Query: 693 AEECQKYLLSLAQSLNNSQAKFRALGNLG----DIF----------ICKKDINGAIKFYE 738
A + Q L LA SL N RA +G DI+ + ++ +
Sbjct: 86 ALQHQHQYLELAHSLRNHTELQRAWATIGRTHLDIYDHCQSRDALLQAQAAFEKSLAIVD 145
Query: 739 QQL-GLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAH 797
++L G Q + + Y LG + +Q+ Y + + + ++ RA
Sbjct: 146 EELEGTLAQGELNEMRTRLYLNLGLTFESLQQTALCNDYFRKSIFLAEQNHLYEDLFRAR 205
Query: 798 GHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLE-------AQVYGNMGITKMNMNVM 850
+L ++ G+++ A +C E + ++ +E AQV ++G +
Sbjct: 206 YNLGTIHWRAGQHSQAMRCLEGARECAHTMRKRFMESECCVVIAQVLQDLGDFLAAKRAL 265
Query: 851 EEAIGYFEQQ-----------------LAMLQQLSGNESVLDRGRAY--GNLGDCYEALG 891
++A Q+ + + QQL E +G LGD + G
Sbjct: 266 KKAYRLGSQKPVQRAAICQNLQHVLAVVRLQQQLEEAEGRDPQGAMVICEQLGDLFSKAG 325
Query: 892 DYEEAIKYYEQYLSVAQSLNRM-QDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHEL 950
D+ A + Y++ L A+ L+R ++A + L M A+ +E+ L +
Sbjct: 326 DFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLATTLGDMKDHHGAVRHYEEELRL--RS 383
Query: 951 GEAFNKAQAYGELGSLHSQLGN-YEQAISCLERQLNIARDMKDRALESDAACGLGGVY-- 1007
G +A+ + + + G+ YE C ++ L+ A+ + L+ L V
Sbjct: 384 GNVLEEAKTWLNIALSREEAGDAYELLAPCFQKALSCAQQAQRPQLQRQVLQHLHTVQLR 443
Query: 1008 ---QQMGEYDTALQYHQLDLQIAEE 1029
Q+ E +T L+ +L +AE+
Sbjct: 444 LQPQEAPETETRLR----ELSVAED 464
Score = 55.8 bits (133), Expect = 5e-07
Identities = 58/229 (25%), Positives = 102/229 (44%), Gaps = 21/229 (9%)
Query: 982 RQLNIARDMKDRA---LESDAACG-LGGVYQQMGEYDTALQYHQLDLQIAEETNNPTCQG 1037
RQL+ A+ RA E A C LG + G Y AL+ H +LQ+ E ++P
Sbjct: 8 RQLSKAKAKAQRAGQRREEAALCHQLGELLAGHGRYAEALEQHWQELQLRERADDPLGCA 67
Query: 1038 RAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQA- 1096
A+ +G + + A+ +Q Q+L +A + + +++++GRTH + ++ Q+
Sbjct: 68 VAHRKIGERLAEMEDYPAALQHQHQYLELAHSLRNHTELQRAWATIGRTHLDIYDHCQSR 127
Query: 1097 VMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGNLEEAQHQLYRASAL-FETIRHEAQ 1155
LQ + L ++E + A G L E + +LY L FE+++ A
Sbjct: 128 DALLQAQAAFEKSLAIVDEELE-------GTLAQGELNEMRTRLYLNLGLTFESLQQTAL 180
Query: 1156 LSTDYKLSLF-DLQTSSYQALQRVLVSL-------GHHDEALAVAERGR 1196
+ ++ S+F Q Y+ L R +L G H +A+ E R
Sbjct: 181 CNDYFRKSIFLAEQNHLYEDLFRARYNLGTIHWRAGQHSQAMRCLEGAR 229
>gi|145386551 SH3 domain and tetratricopeptide repeats 1 [Homo
sapiens]
Length = 1336
Score = 80.9 bits (198), Expect = 1e-14
Identities = 136/610 (22%), Positives = 242/610 (39%), Gaps = 73/610 (11%)
Query: 225 IGTCSLKLRGSVFSALSSAYWSLGNTEK-------STGYMQQDLDVAKTLGDQTGECRAH 277
+ SL+ RGS+ +L S L N + ++ Y++Q L Q +
Sbjct: 730 VKVASLRTRGSLAGSLRSVNLVLQNAPQPHSLPAQTSHYLRQALASLTPGTGQALRGPLY 789
Query: 278 GNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASH 337
+L + G + A+T Q V A + A L +L ++ G P AL
Sbjct: 790 TSLAQLYSHHGCHGPAIT-FMTQAVEASAIAGVRAIVDHLVALAWLHVLHGQSPVALD-- 846
Query: 338 KQCVLLAKQSKDELSEARE--LGNMGAVYIAM-GDFENAVQCHEQHLKIAKDLGNKREEA 394
+L + + SE +E + NM AV + G A + + + L++A+DLG +R +A
Sbjct: 847 ---ILQSVRDAVVASEDQEGVIANMVAVALKRTGRTRQAAESYYRALRVARDLGQQRNQA 903
Query: 395 RAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAAR--------- 445
+N G A+ H LAQ + +A+ + + LG R
Sbjct: 904 VGLANFG-----------ALCLHAGASRLAQHYLLEAVRLFSRLPLGECGRDFTHVLLQL 952
Query: 446 ---CMQD--LERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALK----- 495
C + ++ K Y+E L +A ++ G S L + ++ Y +
Sbjct: 953 GHLCTRQGPAQQGKGYYEWALLVAVEM------GHVESQLRAVQRLCHFYSAVMPSEAQC 1006
Query: 496 --LHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGM---YDQAVKYHRQELQISMEVNDR 550
H+ L +A +++D +G+ + Y +LG Y A+ Y ++ L I +++ +
Sbjct: 1007 VIYHELQLSLACKVADKVLEGQLLETISQLYLSLGTERAYKSALDYTKRSLGIFIDLQKK 1066
Query: 551 ASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGN-FHCSRGE 609
+A Y L + + Q N+A D G+ F E
Sbjct: 1067 EKEAHAWLQAGKIYYILRQSELVDLYIQVAQNVALYTGDPNLGLELFEAAGDIFFDGAWE 1126
Query: 610 YVQAAPYY-EQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLH 668
+A +Y ++ L LA + + E ++C+ L L QE +++ LAL+ L
Sbjct: 1127 REKAVSFYRDRALPLAVTTGNRKAELRLCNKLVALLATLEEPQEGLEFAHMALALSITLG 1186
Query: 669 DKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKF--------RALGNL 720
D+L++ AY L AL + E ++ A SL NS +F + L
Sbjct: 1187 DRLNERVAYHRLA----ALQHRLGHGELAEHFYLKALSLCNSPLEFDEETLYYVKVYLVL 1242
Query: 721 GD-IFICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAY-RMIQKYDKALGYHT 778
GD IF KD A +Y+ L A + +++ + Y L T Y + +K+L ++
Sbjct: 1243 GDIIFYDLKDPFDAAGYYQLALAAAVDLGNKKAQLKIYTRLATIYHNFLLDREKSLFFYQ 1302
Query: 779 QELEVYQELS 788
+ EL+
Sbjct: 1303 KARTFATELN 1312
Score = 58.5 bits (140), Expect = 8e-08
Identities = 103/488 (21%), Positives = 188/488 (38%), Gaps = 44/488 (9%)
Query: 212 HGASVVVLEAALKIG---TCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLG 268
HG S V L+ + S G + + ++ A G T ++ + L VA+ LG
Sbjct: 838 HGQSPVALDILQSVRDAVVASEDQEGVIANMVAVALKRTGRTRQAAESYYRALRVARDLG 897
Query: 269 DQTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDR-------EAASSALSSLG 321
Q + N G+ G R A +H L+ A++L R + L LG
Sbjct: 898 QQRNQAVGLANFGALCLHAGASRLA----QHYLLEAVRLFSRLPLGECGRDFTHVLLQLG 953
Query: 322 HVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFE-NAVQCHEQH 380
H+ T G ++ +L+A + S+ R + + Y A+ E V HE
Sbjct: 954 HLCTRQGPAQQGKGYYEWALLVAVEMGHVESQLRAVQRLCHFYSAVMPSEAQCVIYHELQ 1013
Query: 381 LKIAKDLGNKREEARAYSNLGSAY---HYRRNFDKAMSYHNYVLELAQELMEKAIEMRAY 437
L +A + +K E + + Y R + A+ Y L + +L +K E A+
Sbjct: 1014 LSLACKVADKVLEGQLLETISQLYLSLGTERAYKSALDYTKRSLGIFIDLQKKEKEAHAW 1073
Query: 438 AGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGI-IHQMKGD--YDTAL 494
G ++ E Y + +A D NLG+ + + GD +D A
Sbjct: 1074 LQAGKIYYILRQSELVDLYIQVAQNVALYTGD--------PNLGLELFEAAGDIFFDGAW 1125
Query: 495 KLHKT-------HLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEV 547
+ K L +A + A+ R + L + +++ L +S+ +
Sbjct: 1126 EREKAVSFYRDRALPLAVTTGNRKAELRLCNKLVALLATLEEPQEGLEFAHMALALSITL 1185
Query: 548 NDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSE----ARALSNLGN- 602
DR ++ + LA LG + A Y L++ + E + LG+
Sbjct: 1186 GDRLNERVAYHRLAALQHRLGHGELAEHFYLKALSLCNSPLEFDEETLYYVKVYLVLGDI 1245
Query: 603 -FHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLG-YAHYCLGNYQEAVKYYEQD 660
F+ + + AA YY+ L A DL + + + K+ L H L + ++++ +Y++
Sbjct: 1246 IFYDLKDPF-DAAGYYQLALAAAVDLGNKKAQLKIYTRLATIYHNFLLDREKSLFFYQKA 1304
Query: 661 LALAKDLH 668
A +L+
Sbjct: 1305 RTFATELN 1312
Score = 54.7 bits (130), Expect = 1e-06
Identities = 111/529 (20%), Positives = 195/529 (36%), Gaps = 102/529 (19%)
Query: 560 LAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQ 619
+AVA + G +A + Y L +AR+L +++A L+N G G A Y +
Sbjct: 869 VAVALKRTGRTRQAAESYYRALRVARDLGQQRNQAVGLANFGALCLHAGASRLAQHYLLE 928
Query: 620 YLRLAPDLQDMEGEGKVCHNL-GYAHYCL--GNYQEAVKYYEQDLALAKDLHDKLSQAKA 676
+RL L E H L H C G Q+ YYE L +A ++ SQ +A
Sbjct: 929 AVRLFSRLPLGECGRDFTHVLLQLGHLCTRQGPAQQGKGYYEWALLVAVEMGHVESQLRA 988
Query: 677 YCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKF 736
L + A++ S+A+ + +
Sbjct: 989 VQRLCHFYSAVMP--------------------SEAQ-------------------CVIY 1009
Query: 737 YEQQLGLAHQVKDRRLEASAYAALGTAYRMI---QKYDKALGYHTQELEVYQELSDLPGE 793
+E QL LA +V D+ LE + Y + + Y AL Y + L ++ +L E
Sbjct: 1010 HELQLSLACKVADKVLEGQLLETISQLYLSLGTERAYKSALDYTKRSLGIFIDLQKKEKE 1069
Query: 794 CRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMG-ITKMNMNVMEE 852
A +Y L + + + ++ DP+L +++ G I E+
Sbjct: 1070 AHAWLQAGKIYYILRQSELVDLYIQVAQNVALYTGDPNLGLELFEAAGDIFFDGAWEREK 1129
Query: 853 AIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNR 912
A+ ++ + L +GN ++ + +++ +L
Sbjct: 1130 AVSFYRDRALPLAVTTGNRKA----------------------ELRLCNKLVALLATLEE 1167
Query: 913 MQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGN 972
Q+ GL H A L ++ LG+ N+ AY L +L +LG+
Sbjct: 1168 PQE------GLEFAHMA--------------LALSITLGDRLNERVAYHRLAALQHRLGH 1207
Query: 973 YEQAISCLERQLNIARDMKDRALESD-AACGLGGVYQQMGE---YD-----TALQYHQLD 1023
E A + L++ + LE D VY +G+ YD A Y+QL
Sbjct: 1208 GELAEHFYLKALSLC----NSPLEFDEETLYYVKVYLVLGDIIFYDLKDPFDAAGYYQLA 1263
Query: 1024 LQIAEETNNPTCQGRAYGNLGLTYES-LGTFERAVVYQEQHLSIAAQMN 1071
L A + N Q + Y L Y + L E+++ + ++ + A ++N
Sbjct: 1264 LAAAVDLGNKKAQLKIYTRLATIYHNFLLDREKSLFFYQKARTFATELN 1312
Score = 44.7 bits (104), Expect = 0.001
Identities = 67/353 (18%), Positives = 125/353 (35%), Gaps = 46/353 (13%)
Query: 800 LAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQ 859
+A G+ A + Y L + + L +A N G ++ A Y +
Sbjct: 869 VAVALKRTGRTRQAAESYYRALRVARDLGQQRNQAVGLANFGALCLHAGASRLAQHYLLE 928
Query: 860 QLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKA 919
+ + +L E D LG G ++ YYE L VA + ++ Q +A
Sbjct: 929 AVRLFSRLPLGECGRDFTHVLLQLGHLCTRQGPAQQGKGYYEWALLVAVEMGHVESQLRA 988
Query: 920 YRGLGNGHRA-MGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGN---YEQ 975
+ L + + A M S Q ++ E +L +A ++ + + Q + L+ LG Y+
Sbjct: 989 VQRLCHFYSAVMPSEAQCVIYHELQLSLACKVADKVLEGQLLETISQLYLSLGTERAYKS 1048
Query: 976 AISCLERQLNIARDMKDRALESDAACGLGGVYQQMGE----------------------- 1012
A+ +R L I D++ + E+ A G +Y + +
Sbjct: 1049 ALDYTKRSLGIFIDLQKKEKEAHAWLQAGKIYYILRQSELVDLYIQVAQNVALYTGDPNL 1108
Query: 1013 ------------YDTALQ-------YHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTF 1053
+D A + Y L +A T N + R L +L
Sbjct: 1109 GLELFEAAGDIFFDGAWEREKAVSFYRDRALPLAVTTGNRKAELRLCNKLVALLATLEEP 1168
Query: 1054 ERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRL 1106
+ + + L+++ + D + V+Y L H L + A + + L L
Sbjct: 1169 QEGLEFAHMALALSITLGDRLNERVAYHRLAALQHRLGHGELAEHFYLKALSL 1221
Score = 40.4 bits (93), Expect = 0.022
Identities = 47/200 (23%), Positives = 82/200 (41%), Gaps = 19/200 (9%)
Query: 931 GSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNI---- 986
G +QA + + L VA +LG+ N+A G+L G A L + +
Sbjct: 877 GRTRQAAESYYRALRVARDLGQQRNQAVGLANFGALCLHAGASRLAQHYLLEAVRLFSRL 936
Query: 987 -----ARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQIAEETNNPTCQGRAYG 1041
RD L+ LG + + G Y++ L +A E + Q RA
Sbjct: 937 PLGECGRDFTHVLLQ------LGHLCTRQGPAQQGKGYYEWALLVAVEMGHVESQLRAVQ 990
Query: 1042 NLGLTYESLGTFE-RAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHHAL---QNYSQAV 1097
L Y ++ E + V+Y E LS+A ++ D + ++ + + +L + Y A+
Sbjct: 991 RLCHFYSAVMPSEAQCVIYHELQLSLACKVADKVLEGQLLETISQLYLSLGTERAYKSAL 1050
Query: 1098 MYLQEGLRLAEQLGRREDEA 1117
Y + L + L ++E EA
Sbjct: 1051 DYTKRSLGIFIDLQKKEKEA 1070
Score = 35.4 bits (80), Expect = 0.70
Identities = 31/111 (27%), Positives = 47/111 (42%), Gaps = 12/111 (10%)
Query: 1040 YGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMY 1099
+G + + L + AVV E + A M +A K GRT A ++Y +A
Sbjct: 838 HGQSPVALDILQSVRDAVVASEDQEGVIANMVAVALKRT-----GRTRQAAESYYRA--- 889
Query: 1100 LQEGLRLAEQLGRREDEAKIRHGLGLSLWASGNLEEAQHQLYRASALFETI 1150
LR+A LG++ ++A G +G AQH L A LF +
Sbjct: 890 ----LRVARDLGQQRNQAVGLANFGALCLHAGASRLAQHYLLEAVRLFSRL 936
>gi|38045928 43 kD receptor-associated protein of the synapse
isoform 2 [Homo sapiens]
Length = 353
Score = 77.0 bits (188), Expect = 2e-13
Identities = 58/239 (24%), Positives = 110/239 (46%), Gaps = 13/239 (5%)
Query: 629 DMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALL 688
D+ G +V L AH +G Y+E +K+ + A++L D ++Y NL + + L
Sbjct: 38 DLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDADFLLESYLNLARSNEKLC 97
Query: 689 NFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVK 748
F K K L L + +Q + ++G+ F+ A++ +E+ L AH
Sbjct: 98 EFHKTISYCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSVFQKALESFEKALRYAHNND 157
Query: 749 DRRLEASAYAALGTAYRMIQKYDKALGYHTQELEV---YQELSDLPGECRAHGHLAAVYM 805
D LE +LG+ Y ++ Y+KAL + + E+ Y + L + H+A Y
Sbjct: 158 DAMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNNYGKGWSLKYRAMSQYHMAVAYR 217
Query: 806 ALGKYTMAFKCYEEQLDLGQKLKDPSLEA----------QVYGNMGITKMNMNVMEEAI 854
LG+ A +C EE + + + D L+A + G++ ++++ ++ + E+I
Sbjct: 218 LLGRLGSAMECCEESMKIALQHGDRPLQALCLLCFADIHRSRGDLELSQLKLHCLSESI 276
Score = 60.8 bits (146), Expect = 2e-08
Identities = 56/263 (21%), Positives = 115/263 (43%), Gaps = 13/263 (4%)
Query: 771 DKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDP 830
+KAL T+ LE + SDL G R G L + +G+Y K Q+D ++L+D
Sbjct: 23 EKALQVWTKVLE---KSSDLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDA 79
Query: 831 SLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEAL 890
+ Y N+ + + + I Y + L + +G + G+ ++G+ + L
Sbjct: 80 DFLLESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQL---GGQVSLSMGNAFLGL 136
Query: 891 GDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHEL 950
+++A++ +E+ L A + + + + LG+ + + ++AL K + +
Sbjct: 137 SVFQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNNY 196
Query: 951 GEAFN---KAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVY 1007
G+ ++ +A + + + LG A+ C E + IA DR L++ ++
Sbjct: 197 GKGWSLKYRAMSQYHMAVAYRLLGRLGSAMECCEESMKIALQHGDRPLQALCLLCFADIH 256
Query: 1008 QQMGEYDTALQYHQLDLQIAEET 1030
+ G+ L+ QL L E+
Sbjct: 257 RSRGD----LELSQLKLHCLSES 275
Score = 55.8 bits (133), Expect = 5e-07
Identities = 62/269 (23%), Positives = 119/269 (44%), Gaps = 13/269 (4%)
Query: 250 TEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKD 309
TEK+ +Q V + D G R G L +A G Y+E L Q+ A +L+D
Sbjct: 22 TEKA---LQVWTKVLEKSSDLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELED 78
Query: 310 REAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGD 369
+ + +L + ++ ++ K C+ L + +MG ++ +
Sbjct: 79 ADFLLESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSV 138
Query: 370 FENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELME 429
F+ A++ E+ L+ A + + E R +LGS Y ++++KA+ + EL +
Sbjct: 139 FQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNNYGK 198
Query: 430 K-AIEMRAYA--GLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQM 486
+++ RA + + A R + L A + E+ + IA DR + IH+
Sbjct: 199 GWSLKYRAMSQYHMAVAYRLLGRLGSAMECCEESMKIALQHGDRPLQALCLLCFADIHRS 258
Query: 487 KGDYD-TALKLHKTHLCIAQELSDYAAQG 514
+GD + + LKLH C+++ + Y ++G
Sbjct: 259 RGDLELSQLKLH----CLSESI--YRSKG 281
Score = 50.1 bits (118), Expect = 3e-05
Identities = 51/217 (23%), Positives = 91/217 (41%), Gaps = 11/217 (5%)
Query: 345 KQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAY 404
++S D + R LG + + MG ++ ++ + A++L + +Y NL +
Sbjct: 34 EKSSDLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDADFLLESYLNLARSN 93
Query: 405 HYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIA 464
F K +SY L L + + +G+A + ++A + E+ L A
Sbjct: 94 EKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSVFQKALESFEKALRYA 153
Query: 465 EDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQG-----RAYG- 518
+ D E R +LG + DY+ AL C A EL + +G RA
Sbjct: 154 HNNDDAMLECRVCCSLGSFYAQVKDYEKALFFP----CKAAELVNNYGKGWSLKYRAMSQ 209
Query: 519 -NMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQA 554
+M AY LG A++ + ++I+++ DR QA
Sbjct: 210 YHMAVAYRLLGRLGSAMECCEESMKIALQHGDRPLQA 246
Score = 48.5 bits (114), Expect = 8e-05
Identities = 40/205 (19%), Positives = 93/205 (45%), Gaps = 3/205 (1%)
Query: 503 IAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAV 562
+ ++ SD + R G + A++ +G Y + +K+ ++ + E+ D ++ NLA
Sbjct: 32 VLEKSSDLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDADFLLESYLNLAR 91
Query: 563 AYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLR 622
+ + L + + + + L + Q + ++GN + +A +E+ LR
Sbjct: 92 SNEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSVFQKALESFEKALR 151
Query: 623 LAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLS---QAKAYCN 679
A + D E +VC +LG + + +Y++A+ + + L + S +A + +
Sbjct: 152 YAHNNDDAMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNNYGKGWSLKYRAMSQYH 211
Query: 680 LGLAFKALLNFSKAEECQKYLLSLA 704
+ +A++ L A EC + + +A
Sbjct: 212 MAVAYRLLGRLGSAMECCEESMKIA 236
Score = 47.0 bits (110), Expect = 2e-04
Identities = 41/199 (20%), Positives = 86/199 (43%), Gaps = 3/199 (1%)
Query: 914 QDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNY 973
QDQ K G ++AL + K L + +L F + G L + HS++G Y
Sbjct: 3 QDQTKQQIEKGLQLYQSNQTEKALQVWTKVLEKSSDLMGRF---RVLGCLVTAHSEMGRY 59
Query: 974 EQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQIAEETNNP 1033
++ + Q++ AR+++D ++ L +++ E+ + Y + L +
Sbjct: 60 KEMLKFAVVQIDTARELEDADFLLESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGA 119
Query: 1034 TCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHHALQNY 1093
G+ ++G + L F++A+ E+ L A +D + SLG + +++Y
Sbjct: 120 QLGGQVSLSMGNAFLGLSVFQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDY 179
Query: 1094 SQAVMYLQEGLRLAEQLGR 1112
+A+ + + L G+
Sbjct: 180 EKALFFPCKAAELVNNYGK 198
Score = 42.0 bits (97), Expect = 0.008
Identities = 41/214 (19%), Positives = 85/214 (39%), Gaps = 6/214 (2%)
Query: 910 LNRMQDQAKAYRGLG---NGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSL 966
L + D +R LG H MG ++ L ++ A EL +A ++Y L
Sbjct: 33 LEKSSDLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDADFLLESYLNLARS 92
Query: 967 HSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQI 1026
+ +L + + IS + L + L + +G + + + AL+ + L+
Sbjct: 93 NEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSVFQKALESFEKALRY 152
Query: 1027 AEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMN---DLAAKTVSYSSL 1083
A ++ + R +LG Y + +E+A+ + + + L + +S +
Sbjct: 153 AHNNDDAMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNNYGKGWSLKYRAMSQYHM 212
Query: 1084 GRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEA 1117
+ L A+ +E +++A Q G R +A
Sbjct: 213 AVAYRLLGRLGSAMECCEESMKIALQHGDRPLQA 246
>gi|4506921 small glutamine-rich tetratricopeptide [Homo sapiens]
Length = 313
Score = 72.0 bits (175), Expect = 7e-12
Identities = 43/140 (30%), Positives = 73/140 (52%), Gaps = 5/140 (3%)
Query: 46 RSPDGPVLSKAEFVEKVR---QSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAY 102
RSP S+ + E R + N+ +F A+ Y +A+ ++P N + + NR+AAY
Sbjct: 76 RSPARTPPSEEDSAEAERLKTEGNEQMKVENFEAAVHFYGKAIELNPANAVYFCNRAAAY 135
Query: 103 MKIQQYDKALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQL 162
K+ Y A+ D +A ++P + KAY R G+AL L +H +A+A + L DP +
Sbjct: 136 SKLGNYAGAVQDCERAICIDPAYSKAYGRMGLALSSLNKHVEAVAYYKKALELDPDNETY 195
Query: 163 LVGMVEAAMKSPMRDSLEPT 182
+ A +K +R++ PT
Sbjct: 196 KSNLKIAELK--LREAPSPT 213
Score = 34.7 bits (78), Expect = 1.2
Identities = 25/111 (22%), Positives = 50/111 (45%), Gaps = 12/111 (10%)
Query: 753 EASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTM 812
EA G ++ ++ A+ ++ + +E+ P + AA Y LG Y
Sbjct: 90 EAERLKTEGNEQMKVENFEAAVHFYGKAIELN------PANAVYFCNRAAAYSKLGNYAG 143
Query: 813 AFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAM 863
A + E + + DP+ ++ YG MG+ ++N EA+ Y+++ L +
Sbjct: 144 AVQDCERAICI-----DPAY-SKAYGRMGLALSSLNKHVEAVAYYKKALEL 188
Score = 32.3 bits (72), Expect = 6.0
Identities = 27/126 (21%), Positives = 56/126 (44%), Gaps = 12/126 (9%)
Query: 511 AAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAH 570
+A+ GN + ++ AV ++ + ++++ + A N A AY LG +
Sbjct: 88 SAEAERLKTEGNEQMKVENFEAAVHFYGKAIELN------PANAVYFCNRAAAYSKLGNY 141
Query: 571 DRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDM 630
A+Q + + I + ++A +G S ++V+A YY++ L L PD +
Sbjct: 142 AGAVQDCERAICID------PAYSKAYGRMGLALSSLNKHVEAVAYYKKALELDPDNETY 195
Query: 631 EGEGKV 636
+ K+
Sbjct: 196 KSNLKI 201
>gi|225735593 RNA polymerase II associated protein 3 isoform 2 [Homo
sapiens]
Length = 631
Score = 70.1 bits (170), Expect = 3e-11
Identities = 43/153 (28%), Positives = 78/153 (50%)
Query: 42 TIGQRSPDGPVLSKAEFVEKVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAA 101
T G+R +K + + + + N +G + AI Y +A D N +L +NR+ A
Sbjct: 266 TEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMA 325
Query: 102 YMKIQQYDKALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQ 161
Y+KIQ+Y++A D +A LL+ + KA+ R+G A +LG+ +A F + L +P + Q
Sbjct: 326 YLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQ 385
Query: 162 LLVGMVEAAMKSPMRDSLEPTYQQLQKMKLDKS 194
+ + + K + +E T +Q + + S
Sbjct: 386 AVTELSKIKKKPLKKVIIEETGNLIQTIDVPDS 418
Score = 49.3 bits (116), Expect = 5e-05
Identities = 28/98 (28%), Positives = 50/98 (51%)
Query: 64 QSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNP 123
+ N+ G + AI Y + + DP N +L +NR++AY +++++ A D A LN
Sbjct: 139 KGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNR 198
Query: 124 KWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQ 161
+ KAY R+G A L + +A + L +P + +
Sbjct: 199 SYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFE 236
Score = 37.0 bits (84), Expect = 0.24
Identities = 68/298 (22%), Positives = 116/298 (38%), Gaps = 39/298 (13%)
Query: 804 YMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAM 863
Y GKY A CY + +D A Y + T A YF +
Sbjct: 143 YFKQGKYDEAIDCYTKGMD-----------ADPYNPVLPT-------NRASAYFRLKKFA 184
Query: 864 LQQLSGNESV-LDRG--RAYGNLGDCYEALGDYEEAIKYYEQYLSVA----QSLNRMQDQ 916
+ + N +V L+R +AY G AL EEA K YE+ L + ++ N ++
Sbjct: 185 VAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKI 244
Query: 917 AKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGE--LGSLHSQLGNYE 974
++A N + + E++ + A + NK QA E G+ + G YE
Sbjct: 245 SQALASKENSYPKEADIVIKSTEGERKQIEAQQ-----NKQQAISEKDRGNGFFKEGKYE 299
Query: 975 QAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTA-LQYHQLDLQIAEETNNP 1033
+AI C R IA D + L ++ A Y ++ +Y+ A Q L +
Sbjct: 300 RAIECYTR--GIAADGANALLPANRAM----AYLKIQKYEEAEKDCTQAILLDGSYSKAF 353
Query: 1034 TCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHHALQ 1091
+G A LG E+ FE ++ + + +++ + K + + T + +Q
Sbjct: 354 ARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKKPLKKVIIEETGNLIQ 411
>gi|225735595 RNA polymerase II associated protein 3 isoform 3 [Homo
sapiens]
Length = 506
Score = 67.0 bits (162), Expect = 2e-10
Identities = 38/120 (31%), Positives = 65/120 (54%)
Query: 42 TIGQRSPDGPVLSKAEFVEKVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAA 101
T G+R +K + + + + N +G + AI Y +A D N +L +NR+ A
Sbjct: 107 TEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMA 166
Query: 102 YMKIQQYDKALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQ 161
Y+KIQ+Y++A D +A LL+ + KA+ R+G A +LG+ +A F + L +P + Q
Sbjct: 167 YLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQ 226
Score = 41.2 bits (95), Expect = 0.013
Identities = 23/74 (31%), Positives = 40/74 (54%)
Query: 88 DPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALA 147
DP N +L +NR++AY +++++ A D A LN + KAY R+G A L + +A
Sbjct: 4 DPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKK 63
Query: 148 AFASGLAQDPKSLQ 161
+ L +P + +
Sbjct: 64 DYERVLELEPNNFE 77
Score = 32.7 bits (73), Expect = 4.6
Identities = 38/145 (26%), Positives = 63/145 (43%), Gaps = 17/145 (11%)
Query: 878 RAYGNLGDCYEALGDYEEAIKYYEQYLSVA----QSLNRMQDQAKAYRGLGNGHRAMGSL 933
+AY G AL EEA K YE+ L + ++ N ++ ++A N + +
Sbjct: 43 KAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQALASKENSYPKEADI 102
Query: 934 QQALVCFEKRLVVAHELGEAFNKAQAYGE--LGSLHSQLGNYEQAISCLERQLNIARDMK 991
E++ + A + NK QA E G+ + G YE+AI C R IA D
Sbjct: 103 VIKSTEGERKQIEAQQ-----NKQQAISEKDRGNGFFKEGKYERAIECYTR--GIAADGA 155
Query: 992 DRALESDAACGLGGVYQQMGEYDTA 1016
+ L ++ A Y ++ +Y+ A
Sbjct: 156 NALLPANRAM----AYLKIQKYEEA 176
>gi|225735591 RNA polymerase II associated protein 3 isoform 1 [Homo
sapiens]
Length = 665
Score = 67.0 bits (162), Expect = 2e-10
Identities = 38/120 (31%), Positives = 65/120 (54%)
Query: 42 TIGQRSPDGPVLSKAEFVEKVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAA 101
T G+R +K + + + + N +G + AI Y +A D N +L +NR+ A
Sbjct: 266 TEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMA 325
Query: 102 YMKIQQYDKALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQ 161
Y+KIQ+Y++A D +A LL+ + KA+ R+G A +LG+ +A F + L +P + Q
Sbjct: 326 YLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQ 385
Score = 49.3 bits (116), Expect = 5e-05
Identities = 28/98 (28%), Positives = 50/98 (51%)
Query: 64 QSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNP 123
+ N+ G + AI Y + + DP N +L +NR++AY +++++ A D A LN
Sbjct: 139 KGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNR 198
Query: 124 KWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQ 161
+ KAY R+G A L + +A + L +P + +
Sbjct: 199 SYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFE 236
Score = 36.2 bits (82), Expect = 0.41
Identities = 56/222 (25%), Positives = 89/222 (40%), Gaps = 38/222 (17%)
Query: 804 YMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAM 863
Y GKY A CY + +D A Y + T A YF +
Sbjct: 143 YFKQGKYDEAIDCYTKGMD-----------ADPYNPVLPT-------NRASAYFRLKKFA 184
Query: 864 LQQLSGNESV-LDRG--RAYGNLGDCYEALGDYEEAIKYYEQYLSVA----QSLNRMQDQ 916
+ + N +V L+R +AY G AL EEA K YE+ L + ++ N ++
Sbjct: 185 VAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKI 244
Query: 917 AKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGE--LGSLHSQLGNYE 974
++A N + + E++ + A + NK QA E G+ + G YE
Sbjct: 245 SQALASKENSYPKEADIVIKSTEGERKQIEAQQ-----NKQQAISEKDRGNGFFKEGKYE 299
Query: 975 QAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTA 1016
+AI C R IA D + L ++ A Y ++ +Y+ A
Sbjct: 300 RAIECYTR--GIAADGANALLPANRAM----AYLKIQKYEEA 335
>gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Homo
sapiens]
Length = 1614
Score = 66.2 bits (160), Expect = 4e-10
Identities = 149/680 (21%), Positives = 277/680 (40%), Gaps = 92/680 (13%)
Query: 73 DFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYFRQ 132
D AI+ Y +A+ P + +Y R Y +I A+DD K +PK A ++
Sbjct: 1000 DITLAILNYTQAIKSTPTDADIYFRRGEMY-EITNKVLAIDDFSKCIFYDPKRTDALLKR 1058
Query: 133 GVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEPTYQQLQKMKLD 192
G+ A+ F + L D ++ Q G MK D + T Q+ +M
Sbjct: 1059 GLFYCENENWFAAIEDFTALLNIDHQNSQAR-GQYLLMMK--YYDLAKFTIYQIAEMDKG 1115
Query: 193 KSPFVVVSVVGQELLTA--GHHGASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGNT 250
S +S + Q L+ + +H ++ VL+ G + ++ + L+ T
Sbjct: 1116 LSE---LSPMQQALIYSFCENHDKAIEVLD-----GISWNRAEMTMCALLAKVQMKAKRT 1167
Query: 251 EKSTGYMQQDLDVAKTLGDQTGECRAHG-----NLGSAFFSKGN----YREALTNHRHQL 301
+++ +++ LD A + D+ + A NLG + +GN Y+ A+T+
Sbjct: 1168 KEAVEVLKKALD-AISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTYKLAITD----- 1221
Query: 302 VLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMG 361
L + + + +A + YT I + AL + +LL E + N G
Sbjct: 1222 -LTTAISMDKNSYTAFYNRALCYTKIRELQMALTDYGIVLLL---DATETVKLNTFLNRG 1277
Query: 362 AVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRN-FDKAMSYHNYV 420
+Y+ +G + A++ +Q I++ G + + + H+R N F++A+++ +
Sbjct: 1278 LIYVELGQYGFALEDFKQAALISRTNG-------SLCHATAMCHHRINEFEEAVNFFTWA 1330
Query: 421 LELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNL 480
L++ ++ AY G G++ E KQ Q + L A +A +
Sbjct: 1331 LKINPCFLD------AYVGRGNSYMEYGHDEATKQ---AQKDFLKALHINPAYIKARISF 1381
Query: 481 GIIHQMKGDYDTALKLHKTHLCIAQELSDYAA-QGRAYG--NMGNAYNALGMYDQAVKYH 537
G Q +G + A H T + I + +Y A +GRA MGN + A+
Sbjct: 1382 GYNLQAQGKFQKAWN-HFT-IAIDTDPKNYLAYEGRAVVCLQMGNNFAAM---------- 1429
Query: 538 RQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARAL 597
Q++ +M+++ A + G V ++ +G A++ YQ+ + + + + A
Sbjct: 1430 -QDINAAMKISTTAEFLTNRG---VIHEFMGHKQNAMKDYQDAITLNPKY------SLAY 1479
Query: 598 SNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYY 657
N GN + ++ QA+ Y+ + L+ P+ + V N + L Y+EA + +
Sbjct: 1480 FNAGNIYFHHRQFSQASDYFSKALKFDPENE------YVLMNRAITNTILKKYEEAKEDF 1533
Query: 658 EQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQS---LNNSQAKF 714
A + A Y N + L + AEE LSL + + N +AK
Sbjct: 1534 ------ANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKV 1587
Query: 715 RALGNLGDIFICKKDINGAI 734
R G +G I D N A+
Sbjct: 1588 R--GKIGLIEEAMADYNQAL 1605
Score = 40.8 bits (94), Expect = 0.017
Identities = 104/464 (22%), Positives = 175/464 (37%), Gaps = 86/464 (18%)
Query: 479 NLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHR 538
NLG+ + +G+ KL T L A + N+Y A Y++A+ Y +
Sbjct: 1200 NLGLCYMEEGNLQMTYKLAITDLTTAISMDK------------NSYTAF--YNRALCYTK 1245
Query: 539 -QELQISMEVND--------RASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRD 589
+ELQ+++ + +T N + Y LG + AL+ ++ I+R
Sbjct: 1246 IRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGS 1305
Query: 590 IQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDME-GEGKVCHNLGYAHYCLG 648
+ A A+ H E+ +A ++ L++ P D G G Y Y
Sbjct: 1306 L-CHATAMC-----HHRINEFEEAVNFFTWALKINPCFLDAYVGRGN-----SYMEY--- 1351
Query: 649 NYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLN 708
+ EA K ++D K LH + KA + G +A F KA + +++
Sbjct: 1352 GHDEATKQAQKDFL--KALHINPAYIKARISFGYNLQAQGKFQKA--WNHFTIAIDTDPK 1407
Query: 709 NSQA-KFRALG--NLGDIFICKKDINGAIKF-----YEQQLGLAHQVKDRRLEAS----- 755
N A + RA+ +G+ F +DIN A+K + G+ H+ + A
Sbjct: 1408 NYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQD 1467
Query: 756 ----------AYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYM 805
AY G Y +++ +A Y ++ L+ E V M
Sbjct: 1468 AITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENE-------------YVLM 1514
Query: 806 ALGKYTMAFKCYEE-QLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAML 864
K YEE + D ++ A VY N + E A E+ L
Sbjct: 1515 NRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELA----EEDLNKA 1570
Query: 865 QQLSGNESVLD--RGRAYGNLGDCYEALGDYEEAIKYYEQYLSV 906
L N++++ R + G +G EA+ DY +A+ E Y SV
Sbjct: 1571 LSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALD-LEDYASV 1613
Score = 39.7 bits (91), Expect = 0.037
Identities = 66/313 (21%), Positives = 113/313 (36%), Gaps = 73/313 (23%)
Query: 222 ALKIGTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLG 281
ALKI C L + ++Y G+ E + Q D K L +A + G
Sbjct: 1330 ALKINPCFL----DAYVGRGNSYMEYGHDEATK---QAQKDFLKALHINPAYIKARISFG 1382
Query: 282 SAFFSKGNYREALTNHRHQLVLAMKLKDR-----EAASSALSSLGHVYTAIGDYPNALAS 336
++G +++A NH +A+ + E + +G+ + A+ D A+
Sbjct: 1383 YNLQAQGKFQKAW-NH---FTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKI 1438
Query: 337 HKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARA 396
+ A L N G ++ MG +NA++ ++ + + + + A
Sbjct: 1439 S--------------TTAEFLTNRGVIHEFMGHKQNAMKDYQDAITL------NPKYSLA 1478
Query: 397 YSNLGSAYHYRRNFDKAMSYHNYVLELAQE----LMEKAIE------------------- 433
Y N G+ Y + R F +A Y + L+ E LM +AI
Sbjct: 1479 YFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIE 1538
Query: 434 -----MRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAA-----EGRASSNLGII 483
Y H C++ E A E+ L A LK A + +G+I
Sbjct: 1539 SCPFWAAVYFNRAHFYYCLKQYELA----EEDLNKALSLKPNDALVYNFRAKVRGKIGLI 1594
Query: 484 HQMKGDYDTALKL 496
+ DY+ AL L
Sbjct: 1595 EEAMADYNQALDL 1607
Score = 38.1 bits (87), Expect = 0.11
Identities = 28/96 (29%), Positives = 43/96 (44%), Gaps = 5/96 (5%)
Query: 69 CHD--GDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKI---QQYDKALDDAIKARLLNP 123
CH +F A+ + AL ++P Y R +YM+ + +A D +KA +NP
Sbjct: 1313 CHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINP 1372
Query: 124 KWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKS 159
+ KA G LQ G+ A F + DPK+
Sbjct: 1373 AYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKN 1408
Score = 33.5 bits (75), Expect = 2.7
Identities = 17/63 (26%), Positives = 30/63 (47%)
Query: 70 HDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAY 129
H F A +++AL DP+N + NR+ +++Y++A +D P W Y
Sbjct: 1488 HHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVY 1547
Query: 130 FRQ 132
F +
Sbjct: 1548 FNR 1550
>gi|24308141 small glutamine-rich tetratricopeptide repeat
(TPR)-containing, beta [Homo sapiens]
Length = 304
Score = 65.9 bits (159), Expect = 5e-10
Identities = 31/96 (32%), Positives = 54/96 (56%)
Query: 64 QSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNP 123
+ N + ++ A+ Y +A+ +DP N + Y NR+AA K+ Y A+ D KA ++
Sbjct: 91 EGNNHMKEENYAAAVDCYTQAIELDPNNAVYYCNRAAAQSKLGHYTDAIKDCEKAIAIDS 150
Query: 124 KWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKS 159
K+ KAY R G+AL L + +A+ ++ L DP++
Sbjct: 151 KYSKAYGRMGLALTALNKFEEAVTSYQKALDLDPEN 186
Score = 38.1 bits (87), Expect = 0.11
Identities = 33/123 (26%), Positives = 51/123 (41%), Gaps = 12/123 (9%)
Query: 581 LNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNL 640
L ++ + + +A L + GN H Y A Y Q + L P+ N
Sbjct: 72 LPLSNSVPEDVGKADQLKDEGNNHMKEENYAAAVDCYTQAIELDPN------NAVYYCNR 125
Query: 641 GYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYL 700
A LG+Y +A+K E+ +A+ +KAY +GLA AL F +A +
Sbjct: 126 AAAQSKLGHYTDAIKDCEKAIAIDS------KYSKAYGRMGLALTALNKFEEAVTSYQKA 179
Query: 701 LSL 703
L L
Sbjct: 180 LDL 182
Score = 36.6 bits (83), Expect = 0.32
Identities = 27/128 (21%), Positives = 54/128 (42%), Gaps = 12/128 (9%)
Query: 939 CFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESD 998
C L +++ + E KA + G+ H + NY A+ C + + + + +
Sbjct: 67 CKNDVLPLSNSVPEDVGKADQLKDEGNNHMKEENYAAAVDCYTQAIELDPN------NAV 120
Query: 999 AACGLGGVYQQMGEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVV 1058
C ++G Y A++ + + I + + +AYG +GL +L FE AV
Sbjct: 121 YYCNRAAAQSKLGHYTDAIKDCEKAIAIDSKYS------KAYGRMGLALTALNKFEEAVT 174
Query: 1059 YQEQHLSI 1066
++ L +
Sbjct: 175 SYQKALDL 182
Score = 34.7 bits (78), Expect = 1.2
Identities = 27/103 (26%), Positives = 46/103 (44%), Gaps = 15/103 (14%)
Query: 804 YMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAM 863
+M Y A CY + ++L DP+ A Y N + + +AI E+ +A+
Sbjct: 95 HMKEENYAAAVDCYTQAIEL-----DPN-NAVYYCNRAAAQSKLGHYTDAIKDCEKAIAI 148
Query: 864 LQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSV 906
+ S +AYG +G AL +EEA+ Y++ L +
Sbjct: 149 DSKYS---------KAYGRMGLALTALNKFEEAVTSYQKALDL 182
Score = 32.0 bits (71), Expect = 7.8
Identities = 26/80 (32%), Positives = 39/80 (48%), Gaps = 12/80 (15%)
Query: 488 GDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEV 547
G Y A+K + + I + S +AYG MG A AL +++AV +++ L + E
Sbjct: 133 GHYTDAIKDCEKAIAIDSKYS------KAYGRMGLALTALNKFEEAVTSYQKALDLDPE- 185
Query: 548 NDRASQASTHGNLAVAYQAL 567
ND S NL +A Q L
Sbjct: 186 ND-----SYKSNLKIAEQKL 200
>gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo
sapiens]
Length = 1614
Score = 65.1 bits (157), Expect = 8e-10
Identities = 149/680 (21%), Positives = 276/680 (40%), Gaps = 92/680 (13%)
Query: 73 DFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYFRQ 132
D AI+ Y +A+ P + +Y R Y +I A+DD K +PK A ++
Sbjct: 1000 DITLAILNYTQAIKSTPTDADIYFRRGEMY-EITNKVLAIDDFSKCIFYDPKRTDALLKR 1058
Query: 133 GVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEPTYQQLQKMKLD 192
G+ A+ F + L D ++ Q G MK D + T Q+ +M
Sbjct: 1059 GLFYCENENWFAAIEDFTALLNIDHQNSQAR-GQYLLMMK--YYDLAKFTIYQIAEMDKG 1115
Query: 193 KSPFVVVSVVGQELLTA--GHHGASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGNT 250
S +S + Q L+ + +H ++ VL+ G + ++ + L+ T
Sbjct: 1116 LSE---LSPMQQALIYSFCENHDKAIEVLD-----GISWNRAEMTMCALLAKVQMKAKRT 1167
Query: 251 EKSTGYMQQDLDVAKTLGDQTGECRAHG-----NLGSAFFSKGN----YREALTNHRHQL 301
+++ +++ LD A + D+ + A NLG + +GN Y+ A+T+
Sbjct: 1168 KEAVEVLKKALD-AISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTYKLAITD----- 1221
Query: 302 VLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMG 361
L + + + A + YT I + AL + +LL E + N G
Sbjct: 1222 -LTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVLLL---DATETVKLNTFLNRG 1277
Query: 362 AVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRN-FDKAMSYHNYV 420
+Y+ +G + A++ +Q I++ G + + + H+R N F++A+++ +
Sbjct: 1278 LIYVELGQYGFALEDFKQAALISRTNG-------SLCHATAMCHHRINEFEEAVNFFTWA 1330
Query: 421 LELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNL 480
L++ ++ AY G G++ E KQ Q + L A +A +
Sbjct: 1331 LKINPCFLD------AYVGRGNSYMEYGHDEATKQ---AQKDFLKALHINPAYIKARISF 1381
Query: 481 GIIHQMKGDYDTALKLHKTHLCIAQELSDYAA-QGRAYG--NMGNAYNALGMYDQAVKYH 537
G Q +G + A H T + I + +Y A +GRA MGN + A+
Sbjct: 1382 GYNLQAQGKFQKAWN-HFT-IAIDTDPKNYLAYEGRAVVCLQMGNNFAAM---------- 1429
Query: 538 RQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARAL 597
Q++ +M+++ A + G V ++ +G A++ YQ+ + + + + A
Sbjct: 1430 -QDINAAMKISTTAEFLTNRG---VIHEFMGHKQNAMKDYQDAITLNPKY------SLAY 1479
Query: 598 SNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYY 657
N GN + ++ QA+ Y+ + L+ P+ + V N + L Y+EA + +
Sbjct: 1480 FNAGNIYFHHRQFSQASDYFSKALKFDPENE------YVLMNRAITNTILKKYEEAKEDF 1533
Query: 658 EQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQS---LNNSQAKF 714
A + A Y N + L + AEE LSL + + N +AK
Sbjct: 1534 ------ANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKV 1587
Query: 715 RALGNLGDIFICKKDINGAI 734
R G +G I D N A+
Sbjct: 1588 R--GKIGLIEEAMADYNQAL 1605
Score = 40.4 bits (93), Expect = 0.022
Identities = 94/467 (20%), Positives = 161/467 (34%), Gaps = 118/467 (25%)
Query: 74 FHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWP---KAYF 130
+ AI A+++D + I + NR+ Y KI++ AL D LL+ +
Sbjct: 1215 YKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFL 1274
Query: 131 RQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEPTYQQLQKMK 190
+G+ LG++ AL F +AA+ S SL
Sbjct: 1275 NRGLIYVELGQYGFALEDFK-----------------QAALISRTNGSL----------- 1306
Query: 191 LDKSPFVVVSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSAL---SSAYWSL 247
HH + E A+ T +LK+ A ++Y
Sbjct: 1307 -------------CHATAMCHH--RINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEY 1351
Query: 248 GNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKL 307
G+ E + Q D K L +A + G ++G +++A NH +A+
Sbjct: 1352 GHDEATK---QAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAW-NH---FTIAIDT 1404
Query: 308 KDR-----EAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGA 362
+ E + +G+ + A+ D A+ + A L N G
Sbjct: 1405 DPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIS--------------TTAEFLTNRGV 1450
Query: 363 VYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLE 422
++ MG +NA++ ++ + + + + AY N G+ Y + R F +A Y + L+
Sbjct: 1451 IHEFMGHKQNAMKDYQDAITL------NPKYSLAYFNAGNIYFHHRQFSQASDYFSKALK 1504
Query: 423 LAQE----LMEKAIE------------------------MRAYAGLGHAARCMQDLERAK 454
E LM +AI Y H C++ E A
Sbjct: 1505 FDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELA- 1563
Query: 455 QYHEQQLGIAEDLKDRAA-----EGRASSNLGIIHQMKGDYDTALKL 496
E+ L A LK A + +G+I + DY+ AL L
Sbjct: 1564 ---EEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDL 1607
Score = 40.0 bits (92), Expect = 0.029
Identities = 103/464 (22%), Positives = 175/464 (37%), Gaps = 86/464 (18%)
Query: 479 NLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHR 538
NLG+ + +G+ KL T L A + N+Y + Y++A+ Y +
Sbjct: 1200 NLGLCYMEEGNLQMTYKLAITDLTTAISMDK------------NSY--IAFYNRALCYTK 1245
Query: 539 -QELQISMEVND--------RASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRD 589
+ELQ+++ + +T N + Y LG + AL+ ++ I+R
Sbjct: 1246 IRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGS 1305
Query: 590 IQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDME-GEGKVCHNLGYAHYCLG 648
+ A A+ H E+ +A ++ L++ P D G G Y Y
Sbjct: 1306 L-CHATAMC-----HHRINEFEEAVNFFTWALKINPCFLDAYVGRGN-----SYMEY--- 1351
Query: 649 NYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLN 708
+ EA K ++D K LH + KA + G +A F KA + +++
Sbjct: 1352 GHDEATKQAQKDFL--KALHINPAYIKARISFGYNLQAQGKFQKA--WNHFTIAIDTDPK 1407
Query: 709 NSQA-KFRALG--NLGDIFICKKDINGAIKF-----YEQQLGLAHQVKDRRLEAS----- 755
N A + RA+ +G+ F +DIN A+K + G+ H+ + A
Sbjct: 1408 NYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQD 1467
Query: 756 ----------AYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYM 805
AY G Y +++ +A Y ++ L+ E V M
Sbjct: 1468 AITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENE-------------YVLM 1514
Query: 806 ALGKYTMAFKCYEE-QLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAML 864
K YEE + D ++ A VY N + E A E+ L
Sbjct: 1515 NRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELA----EEDLNKA 1570
Query: 865 QQLSGNESVLD--RGRAYGNLGDCYEALGDYEEAIKYYEQYLSV 906
L N++++ R + G +G EA+ DY +A+ E Y SV
Sbjct: 1571 LSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALD-LEDYASV 1613
Score = 38.1 bits (87), Expect = 0.11
Identities = 28/96 (29%), Positives = 43/96 (44%), Gaps = 5/96 (5%)
Query: 69 CHD--GDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKI---QQYDKALDDAIKARLLNP 123
CH +F A+ + AL ++P Y R +YM+ + +A D +KA +NP
Sbjct: 1313 CHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINP 1372
Query: 124 KWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKS 159
+ KA G LQ G+ A F + DPK+
Sbjct: 1373 AYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKN 1408
Score = 33.5 bits (75), Expect = 2.7
Identities = 17/63 (26%), Positives = 30/63 (47%)
Query: 70 HDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAY 129
H F A +++AL DP+N + NR+ +++Y++A +D P W Y
Sbjct: 1488 HHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVY 1547
Query: 130 FRQ 132
F +
Sbjct: 1548 FNR 1550
>gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo
sapiens]
Length = 1614
Score = 64.7 bits (156), Expect = 1e-09
Identities = 148/679 (21%), Positives = 273/679 (40%), Gaps = 90/679 (13%)
Query: 73 DFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYFRQ 132
D AI+ Y +A+ P + +Y R Y +I A+DD K +PK A ++
Sbjct: 1000 DITLAILNYTQAIKSTPTDADIYFRRGEMY-EITNKVLAIDDFSKCIFYDPKRTDALLKR 1058
Query: 133 GVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEPTYQQLQKMKLD 192
G+ A+ F + L D ++ Q G MK D + T Q+ +M
Sbjct: 1059 GLFYCENENWFAAIEDFTALLNIDHQNSQAR-GQYLLMMK--YYDLAKFTIYQIAEMDKG 1115
Query: 193 KSPFVVVSVVGQELLTA--GHHGASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGNT 250
S +S + Q L+ + +H ++ VL+ G + ++ + L+ T
Sbjct: 1116 LSE---LSPMQQALIYSFCENHDKAIEVLD-----GISWNRAEMTMCALLAKVQMKAKRT 1167
Query: 251 EKSTGYMQQDLDVA----KTLGDQTGECRAHGNLGSAFFSKGN----YREALTNHRHQLV 302
+++ +++ LD + K T NLG + +GN Y+ A+T+
Sbjct: 1168 KEAVEVLKKALDASSHSDKGPDATTISADCLYNLGLCYMEEGNLQMTYKLAITD------ 1221
Query: 303 LAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGA 362
L + + + A + YT I + AL + +LL E + N G
Sbjct: 1222 LTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVLLL---DATETVKLNTFLNRGL 1278
Query: 363 VYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRN-FDKAMSYHNYVL 421
+Y+ +G + A++ +Q I++ G + + + H+R N F++A+++ + L
Sbjct: 1279 IYVELGQYGFALEDFKQAALISRTNG-------SLCHATAMCHHRINEFEEAVNFFTWAL 1331
Query: 422 ELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLG 481
++ ++ AY G G++ E KQ Q + L A +A + G
Sbjct: 1332 KINPCFLD------AYVGRGNSYMEYGHDEATKQ---AQKDFLKALHINPAYIKARISFG 1382
Query: 482 IIHQMKGDYDTALKLHKTHLCIAQELSDYAA-QGRAYG--NMGNAYNALGMYDQAVKYHR 538
Q +G + A H T + I + +Y A +GRA MGN + A+
Sbjct: 1383 YNLQAQGKFQKAWN-HFT-IAIDTDPKNYLAYEGRAVVCLQMGNNFAAM----------- 1429
Query: 539 QELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALS 598
Q++ +M+++ A + G V ++ +G A++ YQ+ + + + + A
Sbjct: 1430 QDINAAMKISTTAEFLTNRG---VIHEFMGHKQNAMKDYQDAITLNPKY------SLAYF 1480
Query: 599 NLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYE 658
N GN + ++ QA+ Y+ + L+ P+ + V N + L Y+EA + +
Sbjct: 1481 NAGNIYFHHRQFSQASDYFSKALKFDPENE------YVLMNRAITNTILKKYEEAKEDF- 1533
Query: 659 QDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQS---LNNSQAKFR 715
A + A Y N + L + AEE LSL + + N +AK R
Sbjct: 1534 -----ANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVR 1588
Query: 716 ALGNLGDIFICKKDINGAI 734
G +G I D N A+
Sbjct: 1589 --GKIGLIEEAMADYNQAL 1605
Score = 40.4 bits (93), Expect = 0.022
Identities = 94/467 (20%), Positives = 161/467 (34%), Gaps = 118/467 (25%)
Query: 74 FHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWP---KAYF 130
+ AI A+++D + I + NR+ Y KI++ AL D LL+ +
Sbjct: 1215 YKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFL 1274
Query: 131 RQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEPTYQQLQKMK 190
+G+ LG++ AL F +AA+ S SL
Sbjct: 1275 NRGLIYVELGQYGFALEDFK-----------------QAALISRTNGSL----------- 1306
Query: 191 LDKSPFVVVSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSAL---SSAYWSL 247
HH + E A+ T +LK+ A ++Y
Sbjct: 1307 -------------CHATAMCHH--RINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEY 1351
Query: 248 GNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKL 307
G+ E + Q D K L +A + G ++G +++A NH +A+
Sbjct: 1352 GHDEATK---QAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAW-NH---FTIAIDT 1404
Query: 308 KDR-----EAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGA 362
+ E + +G+ + A+ D A+ + A L N G
Sbjct: 1405 DPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIS--------------TTAEFLTNRGV 1450
Query: 363 VYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLE 422
++ MG +NA++ ++ + + + + AY N G+ Y + R F +A Y + L+
Sbjct: 1451 IHEFMGHKQNAMKDYQDAITL------NPKYSLAYFNAGNIYFHHRQFSQASDYFSKALK 1504
Query: 423 LAQE----LMEKAIE------------------------MRAYAGLGHAARCMQDLERAK 454
E LM +AI Y H C++ E A
Sbjct: 1505 FDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELA- 1563
Query: 455 QYHEQQLGIAEDLKDRAA-----EGRASSNLGIIHQMKGDYDTALKL 496
E+ L A LK A + +G+I + DY+ AL L
Sbjct: 1564 ---EEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDL 1607
Score = 40.0 bits (92), Expect = 0.029
Identities = 103/464 (22%), Positives = 175/464 (37%), Gaps = 86/464 (18%)
Query: 479 NLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHR 538
NLG+ + +G+ KL T L A + N+Y + Y++A+ Y +
Sbjct: 1200 NLGLCYMEEGNLQMTYKLAITDLTTAISMDK------------NSY--IAFYNRALCYTK 1245
Query: 539 -QELQISMEVND--------RASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRD 589
+ELQ+++ + +T N + Y LG + AL+ ++ I+R
Sbjct: 1246 IRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGS 1305
Query: 590 IQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDME-GEGKVCHNLGYAHYCLG 648
+ A A+ H E+ +A ++ L++ P D G G Y Y
Sbjct: 1306 L-CHATAMC-----HHRINEFEEAVNFFTWALKINPCFLDAYVGRGN-----SYMEY--- 1351
Query: 649 NYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLN 708
+ EA K ++D K LH + KA + G +A F KA + +++
Sbjct: 1352 GHDEATKQAQKDFL--KALHINPAYIKARISFGYNLQAQGKFQKA--WNHFTIAIDTDPK 1407
Query: 709 NSQA-KFRALG--NLGDIFICKKDINGAIKF-----YEQQLGLAHQVKDRRLEAS----- 755
N A + RA+ +G+ F +DIN A+K + G+ H+ + A
Sbjct: 1408 NYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQD 1467
Query: 756 ----------AYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYM 805
AY G Y +++ +A Y ++ L+ E V M
Sbjct: 1468 AITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENE-------------YVLM 1514
Query: 806 ALGKYTMAFKCYEE-QLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAML 864
K YEE + D ++ A VY N + E A E+ L
Sbjct: 1515 NRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELA----EEDLNKA 1570
Query: 865 QQLSGNESVLD--RGRAYGNLGDCYEALGDYEEAIKYYEQYLSV 906
L N++++ R + G +G EA+ DY +A+ E Y SV
Sbjct: 1571 LSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALD-LEDYASV 1613
Score = 38.1 bits (87), Expect = 0.11
Identities = 28/96 (29%), Positives = 43/96 (44%), Gaps = 5/96 (5%)
Query: 69 CHD--GDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKI---QQYDKALDDAIKARLLNP 123
CH +F A+ + AL ++P Y R +YM+ + +A D +KA +NP
Sbjct: 1313 CHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINP 1372
Query: 124 KWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKS 159
+ KA G LQ G+ A F + DPK+
Sbjct: 1373 AYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKN 1408
Score = 33.5 bits (75), Expect = 2.7
Identities = 17/63 (26%), Positives = 30/63 (47%)
Query: 70 HDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAY 129
H F A +++AL DP+N + NR+ +++Y++A +D P W Y
Sbjct: 1488 HHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVY 1547
Query: 130 FRQ 132
F +
Sbjct: 1548 FNR 1550
>gi|73747840 LON peptidase N-terminal domain and ring finger 3
isoform 1 [Homo sapiens]
Length = 759
Score = 64.7 bits (156), Expect = 1e-09
Identities = 48/158 (30%), Positives = 77/158 (48%), Gaps = 13/158 (8%)
Query: 23 RREPESPPASAPIPLFGADTIGQRSPDGPVLSKAEFVEKVRQSNQACHDGDFHTAIVLYN 82
RR + PP + + + +G+ P GP A + + N+ + A++ YN
Sbjct: 213 RRAGQQPPPPLRVNVVLSGLLGKLFP-GP----ARASQLRHEGNRLYRERQVEAALLKYN 267
Query: 83 EALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYFRQGVALQYLGRH 142
EA+ + P + +LYSNRS Y ++ ++ AL DA A L P KA+FR+ AL LG+
Sbjct: 268 EAVKLAPNDHLLYSNRSQIYFTLESHENALHDAEIACKLRPMGFKAHFRKAQALATLGKV 327
Query: 143 ADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLE 180
+AL F ++ D K+ + A RD+LE
Sbjct: 328 EEALREFLYCVSLDGKN--------KRARCEAQRDNLE 357
>gi|238859655 tetratricopeptide repeat domain 31 [Homo sapiens]
Length = 519
Score = 64.3 bits (155), Expect = 1e-09
Identities = 47/141 (33%), Positives = 66/141 (46%), Gaps = 3/141 (2%)
Query: 13 QGPTPARSRRRREPESPPASAPIPLFGADTIGQRSPDGPVLSKAEFVEKVRQSNQACHDG 72
QG A + +E ESPP P Q SP + + E + +G
Sbjct: 263 QGRGLALQKMGQEEESPPREER-PQQSPKV--QASPGLLAAALQQSQELAKLGTSFAQNG 319
Query: 73 DFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYFRQ 132
+H A+VL+ +AL ++PQ+ L+ NRS + ++ Q AL DA A L P WP+ FR
Sbjct: 320 FYHEAVVLFTQALKLNPQDHRLFGNRSFCHERLGQPAWALADAQVALTLRPGWPRGLFRL 379
Query: 133 GVALQYLGRHADALAAFASGL 153
G AL L R +A A F L
Sbjct: 380 GKALMGLQRFREAAAVFQETL 400
>gi|38488692 SH3 domain and tetratricopeptide repeats 2 [Homo sapiens]
Length = 1288
Score = 63.9 bits (154), Expect = 2e-09
Identities = 117/519 (22%), Positives = 190/519 (36%), Gaps = 103/519 (19%)
Query: 459 QQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYG 518
Q L E+L DR+ + L ++ D A+ L + Q L + + +
Sbjct: 742 QALAACEELADRSTQRALCLILSKVYLEHRSPDGAIHYLSQALVLGQLLGEQESFESSLC 801
Query: 519 NMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQ 578
+ AY +A+ L E + + L +A Q G +RA + Y
Sbjct: 802 -LAWAYLLASQAKKALDVLEPLLCSLKETESLTQRGVIYNLLGLALQGEGRVNRAAKSYL 860
Query: 579 NHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQ-----DME-- 631
LN A+E+ D+ ++A A++NLG+ A Y Q +RL +LQ DME
Sbjct: 861 RALNRAQEVGDVHNQAVAMANLGHLSLKSWAQHPARNYLLQAVRLYCELQASKETDMELV 920
Query: 632 ----------------GEGKVCHNL----GYAHYCLGNYQEAVK---------------- 655
G +C+ + G H L + +A K
Sbjct: 921 QVFLWLAQVLVSGHQLTHGLLCYEMALLFGLRHRHLKSQLQATKSLCHFYSSVSPNPEAC 980
Query: 656 --YYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLN----- 708
Y+E LALA+ L D+ + + +LG ++ N + A ++ L + +SL
Sbjct: 981 ITYHEHWLALAQQLRDREMEGRLLESLGQLYR---NLNTARSLRRSLTCIKESLRIFIDL 1037
Query: 709 --------------------------------------NSQAKFRAL---GNLGDIFI-C 726
S+ AL GD+F
Sbjct: 1038 GETDKAAEAWLGAGRLHYLMQEDELVELCLQAAIQTALKSEEPLLALKLYEEAGDVFFNG 1097
Query: 727 KKDINGAIKFYEQ-QLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQ 785
+ + A+++Y + LA ++K R E + L ++ Y+KAL + T +
Sbjct: 1098 TRHRHHAVEYYRAGAVPLARRLKAVRTELRIFNKLTELQISLEGYEKALEFATLAARLST 1157
Query: 786 ELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLG----QKLKDPSLEAQVYGNMG 841
D E A LA VY +L Y MA CY + L L Q K+ A+VY +G
Sbjct: 1158 VTGDQRQELVAFHRLATVYYSLHMYEMAEDCYLKTLSLCPPWLQSPKEALYYAKVYYRLG 1217
Query: 842 -ITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRA 879
+T + +A YF LA L G+E + D R+
Sbjct: 1218 RLTFCQLKDAHDATEYFLLALA-AAVLLGDEELQDTIRS 1255
Score = 63.5 bits (153), Expect = 2e-09
Identities = 102/493 (20%), Positives = 180/493 (36%), Gaps = 52/493 (10%)
Query: 613 AAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLS 672
A P Q L +L D + +C L + + A+ Y Q L L + L ++ S
Sbjct: 736 ACPMLRQALAACEELADRSTQRALCLILSKVYLEHRSPDGAIHYLSQALVLGQLLGEQES 795
Query: 673 QAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDING 732
+ C L A+ KA + + LL + + + LG + +N
Sbjct: 796 FESSLC-LAWAYLLASQAKKALDVLEPLLCSLKETESLTQRGVIYNLLGLALQGEGRVNR 854
Query: 733 AIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPG 792
A K Y + L A +V D +A A A LG A Y Q + +Y EL
Sbjct: 855 AAKSYLRALNRAQEVGDVHNQAVAMANLGHLSLKSWAQHPARNYLLQAVRLYCELQASKE 914
Query: 793 E----CRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMN 848
+ LA V ++ + T CYE L G L+ L++Q+ + +
Sbjct: 915 TDMELVQVFLWLAQVLVSGHQLTHGLLCYEMALLFG--LRHRHLKSQLQATKSLCHFYSS 972
Query: 849 VMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQ 908
V E I Y+E +L++AQ
Sbjct: 973 VSPNP----------------------------------------EACITYHEHWLALAQ 992
Query: 909 SLNRMQDQAKAYRGLGNGHRAMG---SLQQALVCFEKRLVVAHELGEAFNKAQAYGELGS 965
L + + + LG +R + SL+++L C ++ L + +LGE A+A+ G
Sbjct: 993 QLRDREMEGRLLESLGQLYRNLNTARSLRRSLTCIKESLRIFIDLGETDKAAEAWLGAGR 1052
Query: 966 LHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEY-DTALQYHQLD- 1023
LH + E CL+ + A ++ L G V+ + A++Y++
Sbjct: 1053 LHYLMQEDELVELCLQAAIQTALKSEEPLLALKLYEEAGDVFFNGTRHRHHAVEYYRAGA 1112
Query: 1024 LQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSL 1083
+ +A + R + L SL +E+A+ + ++ D + V++ L
Sbjct: 1113 VPLARRLKAVRTELRIFNKLTELQISLEGYEKALEFATLAARLSTVTGDQRQELVAFHRL 1172
Query: 1084 GRTHHALQNYSQA 1096
+++L Y A
Sbjct: 1173 ATVYYSLHMYEMA 1185
Score = 52.4 bits (124), Expect = 6e-06
Identities = 105/475 (22%), Positives = 180/475 (37%), Gaps = 49/475 (10%)
Query: 779 QELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKL-KDPSLEAQVY 837
Q L +EL+D + L+ VY+ A + L LGQ L + S E+ +
Sbjct: 742 QALAACEELADRSTQRALCLILSKVYLEHRSPDGAIHYLSQALVLGQLLGEQESFESSLC 801
Query: 838 GNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAI 897
+ + + ++A+ E L L++ ES+ RG Y LG + G A
Sbjct: 802 --LAWAYLLASQAKKALDVLEPLLCSLKE---TESLTQRGVIYNLLGLALQGEGRVNRAA 856
Query: 898 KYYEQYLSVAQSLNRMQDQAKAYRGLGN-------GHRAMGSLQQALVCFEKRLVVAHEL 950
K Y + L+ AQ + + +QA A LG+ H A L QA+ + + L + E
Sbjct: 857 KSYLRALNRAQEVGDVHNQAVAMANLGHLSLKSWAQHPARNYLLQAVRLYCE-LQASKET 915
Query: 951 GEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQM 1010
Q + L + + C E L + + A L Y +
Sbjct: 916 D--MELVQVFLWLAQVLVSGHQLTHGLLCYEMALLFGLRHRHLKSQLQATKSLCHFYSSV 973
Query: 1011 GEYDTA-LQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGT---FERAVVYQEQHLSI 1066
A + YH+ L +A++ + +GR +LG Y +L T R++ ++ L I
Sbjct: 974 SPNPEACITYHEHWLALAQQLRDREMEGRLLESLGQLYRNLNTARSLRRSLTCIKESLRI 1033
Query: 1067 AAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLS 1126
+ + ++ GR H+ +Q + LQ ++ A + K+ G
Sbjct: 1034 FIDLGETDKAAEAWLGAGRLHYLMQEDELVELCLQAAIQTALKSEEPLLALKLYEEAGDV 1093
Query: 1127 LWASGNLEEAQHQLYRASALFETIRHEAQLSTDYKLSLFDLQTSSYQALQRVLVSLGHHD 1186
+ + YRA A+ R +A + T+ ++ + L + +SL ++
Sbjct: 1094 FFNGTRHRHHAVEYYRAGAVPLARRLKA-VRTELRI---------FNKLTELQISLEGYE 1143
Query: 1187 EALAVAERGRTRAFADLLVERQTGQQDSDPYSPVTIDQILEMVNGQRGLVLYYSL 1241
+AL FA L T VT DQ E+V R +YYSL
Sbjct: 1144 KALE---------FATLAARLST----------VTGDQRQELVAFHRLATVYYSL 1179
Score = 50.4 bits (119), Expect = 2e-05
Identities = 73/367 (19%), Positives = 139/367 (37%), Gaps = 50/367 (13%)
Query: 227 TCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGS---- 282
T SL RG +++ L A G ++ + L+ A+ +GD + A NLG
Sbjct: 829 TESLTQRGVIYNLLGLALQGEGRVNRAAKSYLRALNRAQEVGDVHNQAVAMANLGHLSLK 888
Query: 283 --AFFSKGNY-----------------------------REALTNHR-------HQLVLA 304
A NY + ++ H+ +++ L
Sbjct: 889 SWAQHPARNYLLQAVRLYCELQASKETDMELVQVFLWLAQVLVSGHQLTHGLLCYEMALL 948
Query: 305 MKLKDREAAS--SALSSLGHVYTAIGDYPNA-LASHKQCVLLAKQSKDELSEARELGNMG 361
L+ R S A SL H Y+++ P A + H+ + LA+Q +D E R L ++G
Sbjct: 949 FGLRHRHLKSQLQATKSLCHFYSSVSPNPEACITYHEHWLALAQQLRDREMEGRLLESLG 1008
Query: 362 AVYIAMG---DFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHN 418
+Y + ++ C ++ L+I DLG + A A+ G ++ + +
Sbjct: 1009 QLYRNLNTARSLRRSLTCIKESLRIFIDLGETDKAAEAWLGAGRLHYLMQEDELVELCLQ 1068
Query: 419 YVLELAQELMEKAIEMRAYAGLGHA-ARCMQDLERAKQYHEQ-QLGIAEDLKDRAAEGRA 476
++ A + E + ++ Y G + A +Y+ + +A LK E R
Sbjct: 1069 AAIQTALKSEEPLLALKLYEEAGDVFFNGTRHRHHAVEYYRAGAVPLARRLKAVRTELRI 1128
Query: 477 SSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKY 536
+ L + Y+ AL+ ++ D + A+ + Y +L MY+ A
Sbjct: 1129 FNKLTELQISLEGYEKALEFATLAARLSTVTGDQRQELVAFHRLATVYYSLHMYEMAEDC 1188
Query: 537 HRQELQI 543
+ + L +
Sbjct: 1189 YLKTLSL 1195
>gi|5453958 protein phosphatase 5, catalytic subunit [Homo sapiens]
Length = 499
Score = 62.8 bits (151), Expect = 4e-09
Identities = 37/110 (33%), Positives = 58/110 (52%), Gaps = 2/110 (1%)
Query: 48 PDGPVLSKAEFVEKVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQ 107
P L +AE E Q+N D+ AI Y++A+ ++P N I Y NRS AY++ +
Sbjct: 20 PADGALKRAE--ELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAYLRTEC 77
Query: 108 YDKALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDP 157
Y AL DA +A L+ K+ K Y+R+ + LG+ AL + + + P
Sbjct: 78 YGYALGDATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKP 127
Score = 40.0 bits (92), Expect = 0.029
Identities = 41/174 (23%), Positives = 71/174 (40%), Gaps = 16/174 (9%)
Query: 728 KDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQEL 787
KD AIKFY Q + L A Y AY + Y ALG T+ +E+ ++
Sbjct: 42 KDYENAIKFYSQAIELNPS------NAIYYGNRSLAYLRTECYGYALGDATRAIELDKKY 95
Query: 788 SDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNM 847
+ + AA MALGK+ A + YE + + KD ++ Q + +
Sbjct: 96 ------IKGYYRRAASNMALGKFRAALRDYETVVKVKPHDKDAKMKYQECNKI----VKQ 145
Query: 848 NVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYE 901
E AI E + +++ L ++ + L D + +E +++Y+
Sbjct: 146 KAFERAIAGDEHKRSVVDSLDIESMTIEDEYSGPKLEDGKVTISFMKELMQWYK 199
>gi|157785672 tetratricopeptide repeat domain 24 [Homo sapiens]
Length = 302
Score = 62.8 bits (151), Expect = 4e-09
Identities = 34/99 (34%), Positives = 53/99 (53%)
Query: 523 AYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLN 582
A+NALG Y +A ++H++ + V R Q + G+LA A LG H A +Y + L
Sbjct: 2 AHNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQ 61
Query: 583 IARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYL 621
AR+ D++ + +A LG G+Y QA YY++ L
Sbjct: 62 AARDSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEAL 100
Score = 53.1 bits (126), Expect = 3e-06
Identities = 29/95 (30%), Positives = 51/95 (53%)
Query: 927 HRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNI 986
H A+G+ Q+A +K + +G+ + + +++G L SQLG+++ A L
Sbjct: 3 HNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQA 62
Query: 987 ARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQ 1021
ARD D + A GLG ++G+YD AL+Y++
Sbjct: 63 ARDSGDMKGQWQACEGLGAAAARLGQYDQALKYYK 97
Score = 48.5 bits (114), Expect = 8e-05
Identities = 28/111 (25%), Positives = 54/111 (48%)
Query: 243 AYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQLV 302
A+ +LGN +++ + Q+ D+ ++G + + R+ G+L A G+++ A N+ H L
Sbjct: 2 AHNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQ 61
Query: 303 LAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSE 353
A D + A LG +G Y AL +K+ + ++ D + E
Sbjct: 62 AARDSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEALAQCQKEPDSVRE 112
Score = 47.4 bits (111), Expect = 2e-04
Identities = 26/99 (26%), Positives = 49/99 (49%)
Query: 443 AARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHLC 502
A + + + A+++H++ + + R +GR+ +L GD+ A + L
Sbjct: 2 AHNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQ 61
Query: 503 IAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQEL 541
A++ D Q +A +G A LG YDQA+KY+++ L
Sbjct: 62 AARDSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEAL 100
Score = 43.5 bits (101), Expect = 0.003
Identities = 26/98 (26%), Positives = 45/98 (45%)
Query: 484 HQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQI 543
H G+Y A + H+ + + QGR++G++ A + LG + A + LQ
Sbjct: 3 HNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQA 62
Query: 544 SMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHL 581
+ + D Q L A LG +D+AL++Y+ L
Sbjct: 63 ARDSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEAL 100
Score = 42.4 bits (98), Expect = 0.006
Identities = 25/107 (23%), Positives = 51/107 (47%)
Query: 643 AHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLS 702
AH LGNYQEA +++++ L + + Q +++ +L A L + A + + L
Sbjct: 2 AHNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQ 61
Query: 703 LAQSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVKD 749
A+ + + +++A LG + A+K+Y++ L + D
Sbjct: 62 AARDSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEALAQCQKEPD 108
Score = 41.6 bits (96), Expect = 0.010
Identities = 24/98 (24%), Positives = 51/98 (52%)
Query: 887 YEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVV 946
+ ALG+Y+EA +++++ + S+ + +Q +++ L +G + A + L
Sbjct: 3 HNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQA 62
Query: 947 AHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQL 984
A + G+ + QA LG+ ++LG Y+QA+ + L
Sbjct: 63 ARDSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEAL 100
Score = 41.2 bits (95), Expect = 0.013
Identities = 27/107 (25%), Positives = 47/107 (43%)
Query: 403 AYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLG 462
A++ N+ +A +H +L + ++ + R++ L A + D + A+ + L
Sbjct: 2 AHNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQ 61
Query: 463 IAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSD 509
A D D + +A LG G YD ALK +K L Q+ D
Sbjct: 62 AARDSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEALAQCQKEPD 108
Score = 40.8 bits (94), Expect = 0.017
Identities = 24/103 (23%), Positives = 47/103 (45%)
Query: 324 YTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKI 383
+ A+G+Y A H++ L + R G++ +GD + A + L+
Sbjct: 3 HNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQA 62
Query: 384 AKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQE 426
A+D G+ + + +A LG+A +D+A+ Y+ L Q+
Sbjct: 63 ARDSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEALAQCQK 105
Score = 40.8 bits (94), Expect = 0.017
Identities = 25/98 (25%), Positives = 39/98 (39%)
Query: 1007 YQQMGEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSI 1066
+ +G Y A ++HQ + QGR++G+L LG + A L
Sbjct: 3 HNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQA 62
Query: 1067 AAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGL 1104
A D+ + + LG L Y QA+ Y +E L
Sbjct: 63 ARDSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEAL 100
Score = 40.4 bits (93), Expect = 0.022
Identities = 23/108 (21%), Positives = 54/108 (50%)
Query: 366 AMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQ 425
A+G+++ A + H++ + +G + E+ R++ +L A + A + + L+ A+
Sbjct: 5 ALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQAAR 64
Query: 426 ELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAE 473
+ + + +A GLG AA + ++A +Y+++ L + D E
Sbjct: 65 DSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEALAQCQKEPDSVRE 112
Score = 40.0 bits (92), Expect = 0.029
Identities = 27/88 (30%), Positives = 42/88 (47%), Gaps = 2/88 (2%)
Query: 857 FEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQ 916
F Q+ A L G ++GR++G+L LGD++ A Y L A+ M+ Q
Sbjct: 15 FHQKAADLHGSVGQR--WEQGRSFGSLAFALSQLGDHKAARDNYLHALQAARDSGDMKGQ 72
Query: 917 AKAYRGLGNGHRAMGSLQQALVCFEKRL 944
+A GLG +G QAL +++ L
Sbjct: 73 WQACEGLGAAAARLGQYDQALKYYKEAL 100
Score = 37.7 bits (86), Expect = 0.14
Identities = 23/99 (23%), Positives = 48/99 (48%)
Query: 967 HSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQI 1026
H+ LGNY++A ++ ++ + R + + L Q+G++ A + LQ
Sbjct: 3 HNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQA 62
Query: 1027 AEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLS 1065
A ++ + Q +A LG LG +++A+ Y ++ L+
Sbjct: 63 ARDSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEALA 101
Score = 37.4 bits (85), Expect = 0.19
Identities = 27/104 (25%), Positives = 46/104 (44%)
Query: 733 AIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPG 792
A +F+++ L V R + ++ +L A + + A + L+ ++ D+ G
Sbjct: 12 AREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQAARDSGDMKG 71
Query: 793 ECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQV 836
+ +A L A LG+Y A K Y+E L QK D E V
Sbjct: 72 QWQACEGLGAAAARLGQYDQALKYYKEALAQCQKEPDSVRERLV 115
Score = 35.4 bits (80), Expect = 0.70
Identities = 21/94 (22%), Positives = 43/94 (45%)
Query: 288 GNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQS 347
GNY+EA H+ L + R + SL + +GD+ A ++ + A+ S
Sbjct: 7 GNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQAARDS 66
Query: 348 KDELSEARELGNMGAVYIAMGDFENAVQCHEQHL 381
D + + +GA +G ++ A++ +++ L
Sbjct: 67 GDMKGQWQACEGLGAAAARLGQYDQALKYYKEAL 100
Score = 34.3 bits (77), Expect = 1.6
Identities = 22/77 (28%), Positives = 35/77 (45%)
Query: 233 RGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYRE 292
+G F +L+ A LG+ + + L A+ GD G+ +A LG+A G Y +
Sbjct: 32 QGRSFGSLAFALSQLGDHKAARDNYLHALQAARDSGDMKGQWQACEGLGAAAARLGQYDQ 91
Query: 293 ALTNHRHQLVLAMKLKD 309
AL ++ L K D
Sbjct: 92 ALKYYKEALAQCQKEPD 108
Score = 33.5 bits (75), Expect = 2.7
Identities = 24/103 (23%), Positives = 47/103 (45%), Gaps = 3/103 (2%)
Query: 806 ALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQ 865
ALG Y A + +++ DL + + + +G++ + + A + L LQ
Sbjct: 5 ALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAAR---DNYLHALQ 61
Query: 866 QLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQ 908
+ + + +A LG LG Y++A+KYY++ L+ Q
Sbjct: 62 AARDSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEALAQCQ 104
Score = 33.1 bits (74), Expect = 3.5
Identities = 30/119 (25%), Positives = 53/119 (44%), Gaps = 1/119 (0%)
Query: 604 HCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLAL 663
H + G Y +A ++++ L + +G+ +L +A LG+++ A Y L
Sbjct: 3 HNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQA 62
Query: 664 AKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGD 722
A+D D Q +A LG A L + +A + K L+ Q +S + R + L D
Sbjct: 63 ARDSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEALAQCQKEPDS-VRERLVAKLAD 120
>gi|27262638 sperm associated antigen 1 [Homo sapiens]
Length = 926
Score = 62.0 bits (149), Expect = 7e-09
Identities = 41/181 (22%), Positives = 87/181 (48%), Gaps = 12/181 (6%)
Query: 24 REPESP----PASAPIPLF--GADTIGQRSPDGP------VLSKAEFVEKVRQSNQACHD 71
RE SP PAS P+ + + I +++ D + + F + NQ +D
Sbjct: 577 REKLSPIPAVPASVPLQAWHPAKEMISKQAGDSSSHRQQGITDEKTFKALKEEGNQCVND 636
Query: 72 GDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYFR 131
++ A+ Y+E L ++ + C +Y+NR+ Y+K+ Q+++A D +A L KA++R
Sbjct: 637 KNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYR 696
Query: 132 QGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEPTYQQLQKMKL 191
+ +A + L + +L + DP ++ + + E ++D P ++ ++ K+
Sbjct: 697 RALAHKGLKNYQKSLIDLNKVILLDPSIIEAKMELEEVTRLLNLKDKTAPFNKEKERRKI 756
Query: 192 D 192
+
Sbjct: 757 E 757
Score = 45.8 bits (107), Expect = 5e-04
Identities = 86/363 (23%), Positives = 136/363 (37%), Gaps = 29/363 (7%)
Query: 6 PPAPEPTQGPTPARSRRRREPESPPASAPIPLFGADTI---GQRSPDGPVLSKAEFVEKV 62
P P +G TP +R P ASA G T G + + P K++ E
Sbjct: 399 PARGAPQRGQTPEAGADKRSPRR--ASAAAAAGGGATGHPGGGQGAENPAGLKSQGNELF 456
Query: 63 RQSNQACHDGDFHTAIVLYNEALA-VDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLL 121
R A G + AI L A + + ILYSNR+A Y+K + D +A L
Sbjct: 457 RSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCIQDCNRALEL 516
Query: 122 NPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEP 181
+P K R+ +A + L ++ A + + L D LQL V + M + P
Sbjct: 517 HPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQID-CGLQLANDSVNRLSRILM-ELDGP 574
Query: 182 TYQQLQKMKLDKSPFVVVSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSALS 241
+++ KL P V SV L A H ++ +A + S + +G
Sbjct: 575 NWRE----KLSPIPAVPASVP----LQAWHPAKEMISKQAG---DSSSHRQQGITDEKTF 623
Query: 242 SAYWSLGN-TEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQ 300
A GN Y ++ L EC + N + + EA +
Sbjct: 624 KALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEA----KQD 679
Query: 301 LVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAK---QSKDELSEAREL 357
A++L D + +L H + +Y +L + +LL ++K EL E L
Sbjct: 680 CDQALQLADGNVKAFYRRALAH--KGLKNYQKSLIDLNKVILLDPSIIEAKMELEEVTRL 737
Query: 358 GNM 360
N+
Sbjct: 738 LNL 740
Score = 45.1 bits (105), Expect = 9e-04
Identities = 29/117 (24%), Positives = 54/117 (46%), Gaps = 5/117 (4%)
Query: 41 DTIGQRSPDGPVLSKAEFVEKVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSA 100
DT G + L+ E + N+A + GD+ A++ Y +++ P + Y+NR+
Sbjct: 196 DTAGLTEKEKDFLATRE----KEKGNEAFNSGDYEEAVMYYTRSISALP-TVVAYNNRAQ 250
Query: 101 AYMKIQQYDKALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDP 157
A +K+Q ++ A D K L P KA R+ ++ + +A + L +P
Sbjct: 251 AEIKLQNWNSAFQDCEKVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEP 307
>gi|27262636 sperm associated antigen 1 [Homo sapiens]
Length = 926
Score = 62.0 bits (149), Expect = 7e-09
Identities = 41/181 (22%), Positives = 87/181 (48%), Gaps = 12/181 (6%)
Query: 24 REPESP----PASAPIPLF--GADTIGQRSPDGP------VLSKAEFVEKVRQSNQACHD 71
RE SP PAS P+ + + I +++ D + + F + NQ +D
Sbjct: 577 REKLSPIPAVPASVPLQAWHPAKEMISKQAGDSSSHRQQGITDEKTFKALKEEGNQCVND 636
Query: 72 GDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYFR 131
++ A+ Y+E L ++ + C +Y+NR+ Y+K+ Q+++A D +A L KA++R
Sbjct: 637 KNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYR 696
Query: 132 QGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEPTYQQLQKMKL 191
+ +A + L + +L + DP ++ + + E ++D P ++ ++ K+
Sbjct: 697 RALAHKGLKNYQKSLIDLNKVILLDPSIIEAKMELEEVTRLLNLKDKTAPFNKEKERRKI 756
Query: 192 D 192
+
Sbjct: 757 E 757
Score = 45.8 bits (107), Expect = 5e-04
Identities = 86/363 (23%), Positives = 136/363 (37%), Gaps = 29/363 (7%)
Query: 6 PPAPEPTQGPTPARSRRRREPESPPASAPIPLFGADTI---GQRSPDGPVLSKAEFVEKV 62
P P +G TP +R P ASA G T G + + P K++ E
Sbjct: 399 PARGAPQRGQTPEAGADKRSPRR--ASAAAAAGGGATGHPGGGQGAENPAGLKSQGNELF 456
Query: 63 RQSNQACHDGDFHTAIVLYNEALA-VDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLL 121
R A G + AI L A + + ILYSNR+A Y+K + D +A L
Sbjct: 457 RSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCIQDCNRALEL 516
Query: 122 NPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEP 181
+P K R+ +A + L ++ A + + L D LQL V + M + P
Sbjct: 517 HPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQID-CGLQLANDSVNRLSRILM-ELDGP 574
Query: 182 TYQQLQKMKLDKSPFVVVSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSALS 241
+++ KL P V SV L A H ++ +A + S + +G
Sbjct: 575 NWRE----KLSPIPAVPASVP----LQAWHPAKEMISKQAG---DSSSHRQQGITDEKTF 623
Query: 242 SAYWSLGN-TEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQ 300
A GN Y ++ L EC + N + + EA +
Sbjct: 624 KALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEA----KQD 679
Query: 301 LVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAK---QSKDELSEAREL 357
A++L D + +L H + +Y +L + +LL ++K EL E L
Sbjct: 680 CDQALQLADGNVKAFYRRALAH--KGLKNYQKSLIDLNKVILLDPSIIEAKMELEEVTRL 737
Query: 358 GNM 360
N+
Sbjct: 738 LNL 740
Score = 45.1 bits (105), Expect = 9e-04
Identities = 29/117 (24%), Positives = 54/117 (46%), Gaps = 5/117 (4%)
Query: 41 DTIGQRSPDGPVLSKAEFVEKVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSA 100
DT G + L+ E + N+A + GD+ A++ Y +++ P + Y+NR+
Sbjct: 196 DTAGLTEKEKDFLATRE----KEKGNEAFNSGDYEEAVMYYTRSISALP-TVVAYNNRAQ 250
Query: 101 AYMKIQQYDKALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDP 157
A +K+Q ++ A D K L P KA R+ ++ + +A + L +P
Sbjct: 251 AEIKLQNWNSAFQDCEKVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEP 307
>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
[Homo sapiens]
Length = 774
Score = 62.0 bits (149), Expect = 7e-09
Identities = 81/389 (20%), Positives = 158/389 (40%), Gaps = 51/389 (13%)
Query: 435 RAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTAL 494
R + L + +D AK Y+++ L + RA NLG + + + + A+
Sbjct: 407 RHASALNNLGTLTRDTAEAKMYYQRALQL------HPQHNRALFNLGNLLKSQEKKEEAI 460
Query: 495 KLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQA 554
L K + E +D AY ++ + + +A + ++ ++ + +D
Sbjct: 461 TLLKDSIKYGPEFAD------AYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSD----- 509
Query: 555 STHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAA 614
H N V G ++A+ HYQ + ++ S A+ NLG + S GE A
Sbjct: 510 -LHNNYGVFLVDTGLPEKAVAHYQQAIKLS------PSHHVAMVNLGRLYRSLGENSMAE 562
Query: 615 PYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQA 674
+Y++ L++A + ++ LG +Y G Y+EA++ Y++ AL + SQ
Sbjct: 563 EWYKRALQVA-------HKAEILSPLGALYYNTGRYEEALQIYQEAAAL------QPSQR 609
Query: 675 KAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAI 734
+ L + +AE+ +++S L I+ +++ + A+
Sbjct: 610 ELRLALAQVLAVMGQTKEAEKMTNHIVS------EETGCLECYRLLSAIYSKQENHDKAL 663
Query: 735 KFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGEC 794
++ L L + KD ++ + + G R DKA + V +L+ P +
Sbjct: 664 DAIDKALQL--KPKDPKVISELFFTKGNQLREQNLLDKAF----ESYRVAVQLN--PDQA 715
Query: 795 RAHGHLAAVYMALGKYTMAFKCYEEQLDL 823
+A ++ + GKY A YE L L
Sbjct: 716 QAWMNMGGIQHIKGKYVSARAYYERALQL 744
Score = 58.2 bits (139), Expect = 1e-07
Identities = 104/446 (23%), Positives = 166/446 (37%), Gaps = 79/446 (17%)
Query: 554 ASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQA 613
A H N A + G + A+ HY+ L + A AL+NLG E A
Sbjct: 375 AKVHYNYANFLKDQGRNKEAIYHYRTALKL------YPRHASALNNLGTLTRDTAE---A 425
Query: 614 APYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKD-LHDKLS 672
YY++ L+L P HN A + LGN ++ + E+ + L KD +
Sbjct: 426 KMYYQRALQLHPQ-----------HNR--ALFNLGNLLKSQEKKEEAITLLKDSIKYGPE 472
Query: 673 QAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDING 732
A AY +L F +AEE + + N N G +
Sbjct: 473 FADAYSSLASLLAEQERFKEAEEIYQ------TGIKNCPDSSDLHNNYGVFLVDTGLPEK 526
Query: 733 AIKFYEQQLGLA--HQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDL 790
A+ Y+Q + L+ H V A LG YR +LG ++ E Y+ +
Sbjct: 527 AVAHYQQAIKLSPSHHV--------AMVNLGRLYR-------SLGENSMAEEWYKRALQV 571
Query: 791 PGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLE-AQVYGNMGITK----M 845
+ L A+Y G+Y A + Y+E L ++ L AQV MG TK M
Sbjct: 572 AHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKM 631
Query: 846 NMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLS 905
+++ E G E Y L Y ++++A+ ++ L
Sbjct: 632 TNHIVSEETGCLE--------------------CYRLLSAIYSKQENHDKALDAIDKALQ 671
Query: 906 VAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGS 965
+ ++ + + GN R L +A + VA +L ++AQA+ +G
Sbjct: 672 LKPKDPKVISEL--FFTKGNQLREQNLLDKAFESYR----VAVQLNP--DQAQAWMNMGG 723
Query: 966 LHSQLGNYEQAISCLERQLNIARDMK 991
+ G Y A + ER L + D K
Sbjct: 724 IQHIKGKYVSARAYYERALQLVPDSK 749
Score = 53.1 bits (126), Expect = 3e-06
Identities = 93/406 (22%), Positives = 157/406 (38%), Gaps = 88/406 (21%)
Query: 275 RAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNAL 334
+ H N + +G +EA+ ++R A+KL R A SAL++LG T D A
Sbjct: 376 KVHYNYANFLKDQGRNKEAIYHYR----TALKLYPRHA--SALNNLG---TLTRDTAEAK 426
Query: 335 ASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEA 394
+++ + L Q R L N+G + + E A+ + +K + A
Sbjct: 427 MYYQRALQLHPQHN------RALFNLGNLLKSQEKKEEAITLLKDSIKYGPEF------A 474
Query: 395 RAYSNLGSAYHYRRNFDKAMS---------------YHNYVLELAQE-LMEKAIEMR--- 435
AYS+L S + F +A ++NY + L L EKA+
Sbjct: 475 DAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQA 534
Query: 436 ---------AYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQM 486
A LG R + + A++++++ L +A + S LG ++
Sbjct: 535 IKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAH-------KAEILSPLGALYYN 587
Query: 487 KGDYDTALKLHKTHLCIAQELSDYA-AQGRAYGNMGNAYNALGMYDQAVKYHRQELQISM 545
G Y+ AL++++ + + A + MG A M + V L+
Sbjct: 588 TGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYR 647
Query: 546 EVNDRASQASTHGNLAVAYQALGAHDRALQ--------------------HYQNHLNIAR 585
++ S+ H +AL A D+ALQ QN L+ A
Sbjct: 648 LLSAIYSKQENHD------KALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAF 701
Query: 586 ELRDIQ-----SEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPD 626
E + +A+A N+G +G+YV A YYE+ L+L PD
Sbjct: 702 ESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPD 747
Score = 37.4 bits (85), Expect = 0.19
Identities = 69/330 (20%), Positives = 121/330 (36%), Gaps = 76/330 (23%)
Query: 879 AYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALV 938
A NLG D EA YY++ L + NR A LGN ++ ++A+
Sbjct: 411 ALNNLGTLTR---DTAEAKMYYQRALQLHPQHNR------ALFNLGNLLKSQEKKEEAIT 461
Query: 939 CFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKD------ 992
+ + E A AY L SL ++ +++A + + D D
Sbjct: 462 LLKDSIKYGPEF------ADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYG 515
Query: 993 -----------------RALESD-----AACGLGGVYQQMGEYDTALQYHQLDLQIAEET 1030
+A++ A LG +Y+ +GE A ++++ LQ+A +
Sbjct: 516 VFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKA 575
Query: 1031 NNPTCQGRAYGNLGLTYESLGTFERAVVYQ----------EQHLSIAAQMNDLAAKT--- 1077
+ G Y N G E+L ++ A Q Q L++ Q + T
Sbjct: 576 EILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHI 635
Query: 1078 --------VSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWA 1129
Y L + +N+ +A+ + + L+L + + K+ L +
Sbjct: 636 VSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQL------KPKDPKVISEL---FFT 686
Query: 1130 SGNLEEAQHQLYRASALFETIRHEAQLSTD 1159
GN Q+ L +A FE+ R QL+ D
Sbjct: 687 KGNQLREQNLLDKA---FESYRVAVQLNPD 713
Score = 32.7 bits (73), Expect = 4.6
Identities = 24/76 (31%), Positives = 34/76 (44%), Gaps = 4/76 (5%)
Query: 95 YSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKA----YFRQGVALQYLGRHADALAAFA 150
Y SA Y K + +DKALD KA L PK PK +F +G L+ A ++
Sbjct: 646 YRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYR 705
Query: 151 SGLAQDPKSLQLLVGM 166
+ +P Q + M
Sbjct: 706 VAVQLNPDQAQAWMNM 721
>gi|90669931 tetratricopeptide repeat domain 12 [Homo sapiens]
Length = 705
Score = 59.3 bits (142), Expect = 5e-08
Identities = 34/95 (35%), Positives = 53/95 (55%)
Query: 64 QSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNP 123
+ N+A +G++ TAI+ Y+E L +LY+NR+ AYMK++ Y+KAL D A +
Sbjct: 112 KGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDE 171
Query: 124 KWPKAYFRQGVALQYLGRHADALAAFASGLAQDPK 158
K KAYF G A L ++ + + L +PK
Sbjct: 172 KCTKAYFHMGKANLALKNYSVSRECYKKILEINPK 206
Score = 37.0 bits (84), Expect = 0.24
Identities = 37/125 (29%), Positives = 57/125 (45%), Gaps = 14/125 (11%)
Query: 584 ARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCH-NLGY 642
A+ R+ + A AL GN + G Y A Y + L D+ KV + N
Sbjct: 96 AKRRRENKVLADALKEKGNEAFAEGNYETAILRYSEGLEKLKDM-------KVLYTNRAQ 148
Query: 643 AHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLS 702
A+ L +Y++A+ D A +K + KAY ++G A AL N+S + EC K +L
Sbjct: 149 AYMKLEDYEKALV----DCEWALKCDEKCT--KAYFHMGKANLALKNYSVSRECYKKILE 202
Query: 703 LAQSL 707
+ L
Sbjct: 203 INPKL 207
Score = 33.1 bits (74), Expect = 3.5
Identities = 26/99 (26%), Positives = 42/99 (42%), Gaps = 6/99 (6%)
Query: 852 EAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLN 911
EA + A+L+ G E + D Y N Y L DYE+A+ E L +
Sbjct: 115 EAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKC- 173
Query: 912 RMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHEL 950
KAY +G + A+ + + C++K L + +L
Sbjct: 174 -----TKAYFHMGKANLALKNYSVSRECYKKILEINPKL 207
Score = 33.1 bits (74), Expect = 3.5
Identities = 27/99 (27%), Positives = 45/99 (45%), Gaps = 14/99 (14%)
Query: 889 ALGDYEEAIKYYEQYLSVAQSLNRMQ-DQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVA 947
A G+YE AI Y + L + + + ++A+AY L + +A+ + AL C EK
Sbjct: 118 AEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEK----- 172
Query: 948 HELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNI 986
+AY +G + L NY + C ++ L I
Sbjct: 173 --------CTKAYFHMGKANLALKNYSVSRECYKKILEI 203
>gi|91982772 mucin 17 [Homo sapiens]
Length = 4493
Score = 58.5 bits (140), Expect = 8e-08
Identities = 115/567 (20%), Positives = 210/567 (37%), Gaps = 80/567 (14%)
Query: 1941 TELPKRLSLDSSSSLESLASAQSVSNALPLGYQQPPFSPTGADS---------------- 1984
T +P + +SS +L++ +V++ Y Q SPT AD
Sbjct: 1870 TSIPVSTTTVASSETNTLSTTPAVTSTPVTTYAQVSSSPTTADGSSMPTSTPREGRPPLT 1929
Query: 1985 ---IASDAISVYSLSSIASSMSFVSKPEG--GSEGGGPGGRQDHDRSKNAYLQRSTLPRS 2039
+++ ++ +++++++++ P P AY + ST P +
Sbjct: 1930 SIPVSTTTVASSEINTLSTTLADTRTPVTTYSQASSSPTTADGTSMPTPAYSEGST-PLT 1988
Query: 2040 QLPPQTRPAGNKDEEEYEGFSIISNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVSS 2099
+P T + + + ++ P T E ++ P TAGG + S+
Sbjct: 1989 SMPLSTTLVVSSEASTLSTTPVDTSTPATTSTEGSSS----------PTTAGGTSIQTST 2038
Query: 2100 KGSISTP--NSPVKMTLIPSPN------SPFQKVGKLASSDTGESDQSSTETDSTVKSQE 2151
+TP PV TL+ S +P ++ +S S ++ + T+ +
Sbjct: 2039 PSERTTPLAGMPVSTTLVVSSEGNTLSTTPVDSKTQVTNSTEASSSATAEGSSMTISAPS 2098
Query: 2152 ESNPKLDPQELAQKILEETQSHLIAVERLQRSGG-----QVSKSNNPEDGVQAPSSTAVF 2206
E +P L L+ + ++ ++ + + +VS S P +G +ST +
Sbjct: 2099 EGSPLLTSIPLSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPIPTEGTSMQTST--Y 2156
Query: 2207 RASETSAFSRPVLSHQKSQPSPVTVKPKPPARSSSLPKVSSGYSSPTTSEMSIKDSPSQH 2266
T S PV + + + T+ P S+ + + SSPTTSE S
Sbjct: 2157 SDRRTPLTSMPVSTTVVASSAISTLSTTPVDTSTPVTNSTEARSSPTTSE-----GTSMP 2211
Query: 2267 SGRPSPGCDSQTSQLDQPLFKLKYPSSPYSAHISKSPRNMSPSSGHQSPAGSAPSPALSY 2326
+ PS G TS P+ + +S S +S +P + S + A S+P+ A
Sbjct: 2212 TSTPSEGSTPFTS---MPVSTMPVVTSEAST-LSATPVDTSTPVTTSTEATSSPTTAEGT 2267
Query: 2327 S---SAGSARSSPADAPDIDKLKMAAIDEKVQA---VHNLKMFWQSTPQHSTGPMKIFRG 2380
S S S ++P + + +A + + V + F ST S P
Sbjct: 2268 SIPTSTLSEGTTPLTSIPVSHTLVANSEVSTLSTTPVDSNTPFTTSTEASSPPPTAEGTS 2327
Query: 2381 APGTMTSKRDV-LSLLNLSPRHNKKEEGVDKLELKELSLQQHD-----------GAPPKA 2428
P + +S+ + L+ + +S V E LS D G+ P
Sbjct: 2328 MPTSTSSEGNTPLTRMPVSTTM------VASFETSTLSTTPADTSTPVTTYSQAGSSPTT 2381
Query: 2429 PPNGHWRTETTSLGSLPLPAGPPATAP 2455
+ T T S GS PL + P +T P
Sbjct: 2382 ADDTSMPTSTYSEGSTPLTSVPVSTMP 2408
Score = 51.2 bits (121), Expect = 1e-05
Identities = 111/563 (19%), Positives = 203/563 (36%), Gaps = 60/563 (10%)
Query: 1931 LQSLLSLFDSTELPKRLSLDSSSSLESLASAQSVSNALPLGYQQPPFS---PTGADSIAS 1987
+ S + +T + + + +S+ S +A+ S + + P P +AS
Sbjct: 1586 VSSEANTLSTTPIDSKTQVTASTEASSSTTAEGSSMTISTPSEGSPLLTSIPVSTTPVAS 1645
Query: 1988 DAISVYSLSSIASSMSFVSKPEGGSEGGGPGGRQDHDRSKNAYLQRSTLPRSQLPPQTRP 2047
S S + + S+ ++ E S P + + Y + T P + + +T P
Sbjct: 1646 PEASTLSTTPVDSNSPVITSTEVSSS---PTPAEGTSMPTSTYTEGRT-PLTSITVRTTP 1701
Query: 2048 AGNKDEEEYEGFSIISNEPLATYQENRNTCFSPD-----HKQPQPGTAGGMRVSVSSKGS 2102
+ + ++ P+ T E R++ + + + P GT + VS+
Sbjct: 1702 VASSAISTLSTTPVDNSTPVTTSTEARSSPTTSEGTSMPNSTPSEGTTPLTSIPVSTTPV 1761
Query: 2103 ISTPNSPVKMTLIPSPNSPFQKVGKLASSDTGESDQSSTETDSTVKSQEESNPKLDPQEL 2162
+S+ S + T I + +S T E T T S + S P +
Sbjct: 1762 LSSEASTLSATPIDTSTPVTTSTEATSSPTTAEGTSIPTSTLSEGMTPLTSTP------V 1815
Query: 2163 AQKILEETQSHLIAVERLQRSGG-----QVSKSNNPEDGVQAPSSTAVFRASETSAFSRP 2217
+ ++ +++ ++ + + VS S P +G +ST T+ S P
Sbjct: 1816 SHTLVANSEASTLSTTPVDSNSPVVTSTAVSSSPTPAEGTSIATSTP--SEGSTALTSIP 1873
Query: 2218 VLSHQKSQPSPVTVKPKPPARSSSLPKVSSGYSSPTTSEMSIKDSPSQHSGRP------- 2270
V + + T+ P S+ + + SSPTT++ S + + GRP
Sbjct: 1874 VSTTTVASSETNTLSTTPAVTSTPVTTYAQVSSSPTTADGSSMPTSTPREGRPPLTSIPV 1933
Query: 2271 --SPGCDSQTSQLDQPLFKLKYPSSPYSAHISKSPRNMSPSSGHQSPA---GSAP--SPA 2323
+ S+ + L L + P + YS S SP +S +PA GS P S
Sbjct: 1934 STTTVASSEINTLSTTLADTRTPVTTYS-QASSSPTTADGTS-MPTPAYSEGSTPLTSMP 1991
Query: 2324 LSYSSAGSARSSPADAPDIDKLKMAAIDEKVQAVHNL---KMFWQSTPQHSTGPMKIFRG 2380
LS + S+ +S +D A + + STP T P+ G
Sbjct: 1992 LSTTLVVSSEASTLSTTPVDTSTPATTSTEGSSSPTTAGGTSIQTSTPSERTTPL---AG 2048
Query: 2381 APGTMT----SKRDVLSLLNLSPRHNKKEEGVDKLELKELSLQQHDGAPPKAPPNGHWRT 2436
P + T S+ + LS + + K + + E + + AP G
Sbjct: 2049 MPVSTTLVVSSEGNTLSTTPV----DSKTQVTNSTEASSSATAEGSSMTISAPSEG---- 2100
Query: 2437 ETTSLGSLPLPAGPPATAPARPL 2459
+ L S+PL P A+ A L
Sbjct: 2101 -SPLLTSIPLSTTPVASPEASTL 2122
Score = 50.8 bits (120), Expect = 2e-05
Identities = 115/543 (21%), Positives = 185/543 (34%), Gaps = 56/543 (10%)
Query: 1941 TELPKRLSLDSSSSLESLASAQSVSNALPLGYQQPPFSPTGADS--IASDAISVYSLSSI 1998
T P S ++SSS + A S+ + P G ++ P + + +AS S S +
Sbjct: 2955 TRTPVTTSAEASSS-PTTAEGTSMPISTP-GERRTPLTSMSVSTMPVASSEASTLSRTPA 3012
Query: 1999 ASSMSFVSKPEGGSEGGGPGGRQDHDRSKNAYLQRSTLPRSQLPPQTRPAGNKDEEEYEG 2058
+S + E S P + + + ST P + +P T P +
Sbjct: 3013 DTSTPVTTSTEASSS---PTTAEGTGIPISTPSEGST-PLTSIPVSTTPVAIPEASTLST 3068
Query: 2059 FSIISNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVSSKGSISTPNSPVKMTLIPSP 2118
+ SN P+ T E ++ P P M +S S+GS PV T + S
Sbjct: 3069 TPVDSNSPVVTSTEVSSS--------PTPAEGTSMPISTYSEGSTPLTGVPVSTTPVTS- 3119
Query: 2119 NSPFQKVGKLASSDTGESDQSSTETD---STVKSQEESNPKLDPQELAQKILEETQSHLI 2175
+ L+++ S +T T+ S S+ S P P E + + S ++
Sbjct: 3120 ----SAISTLSTTPVDTSTPVTTSTEAHSSPTTSEGTSMPTSTPSEGSTPLTYMPVSTML 3175
Query: 2176 AVERLQRSGGQVSKSNNPEDGVQAPSSTAVFRASETSAFSRPVLSHQKSQPS------PV 2229
V S + S P D P +T+ S T+A + + S+ PV
Sbjct: 3176 VV-----SSEDSTLSATPVD-TSTPVTTSTEATSSTTAEGTSIPTSTPSEGMTPLTSVPV 3229
Query: 2230 TVKPKPPARSSSLPKVSSGYSSPTTSEMSIKDSPSQHSGRPSPGC---DSQTSQLDQPLF 2286
+ P + +S L ++P T+ SP G P + T P+
Sbjct: 3230 SNTPVASSEASILSTTPVDSNTPLTTSTEASSSPPTAEGTSMPTSTPSEGSTPLTSMPVS 3289
Query: 2287 KLKYPSSPYSAHISKSPRNMSPSSGHQSPAGSAPS-------PALSYSSAG------SAR 2333
SS S +S +P + S S A S+P P +YS S
Sbjct: 3290 TTTVASSETST-LSTTPADTSTPVTTYSQASSSPPIADGTSMPTSTYSEGSTPLTNMSFS 3348
Query: 2334 SSPADAPDIDKLKMAAIDEKVQAVHNLKMFWQSTPQHSTGPMKIFRGAPGTMTSKRDVLS 2393
++P + + L +D + + T T T + V +
Sbjct: 3349 TTPVVSSEASTLSTTPVDTSTPVTTSTEASLSPTTAEGTSIPTSSPSEGTTPLASMPVST 3408
Query: 2394 LLNLSPRHNK-KEEGVDKLELKELSLQQHDGAPPKAPPNGHWRTETTSLGSLPLPAGPPA 2452
+S N VD L S + + P T TTS GS PL P +
Sbjct: 3409 TPVVSSEVNTLSTTPVDSNTLVTTSTEA--SSSPTIAEGTSLPTSTTSEGSTPLSIMPLS 3466
Query: 2453 TAP 2455
T P
Sbjct: 3467 TTP 3469
Score = 50.4 bits (119), Expect = 2e-05
Identities = 93/463 (20%), Positives = 157/463 (33%), Gaps = 66/463 (14%)
Query: 2035 TLPRSQLPPQTRPAGNKDEEEYEGFSIISNEPLATYQENRNTCFSPDHKQPQPGTAG-GM 2093
T P + P N + + SN PL T S + P P G M
Sbjct: 982 TTPLTSTPVSHTLVANSEASTLSTTPVDSNTPLTT---------STEASSPPPTAEGTSM 1032
Query: 2094 RVSVSSKGSISTPNSPVKMTLIPSPNSPFQKVGKLASSDT----GESDQSSTETDST--- 2146
S S+GS PV T++ S + +S ++ SST D T
Sbjct: 1033 PTSTPSEGSTPLTRMPVSTTMVASSETSTLSTTPADTSTPVTTYSQASSSSTTADGTSMP 1092
Query: 2147 VKSQEESNPKLDPQELAQKILEETQSHLIAVERLQRS-----GGQVSKSNNPEDGVQAPS 2201
+ E + L ++ +++ +++ ++ + S + S S +G P+
Sbjct: 1093 TSTYSEGSTPLTSVPVSTRLVVSSEASTLSTTPVDTSIPVTTSTEASSSPTTAEGTSIPT 1152
Query: 2202 S---------------TAVFRASETSAFSR-PVLSHQKSQPSPVTVKPKPPARSSSLPKV 2245
S T + +SE + S PV S + S P P A +S+P
Sbjct: 1153 SPPSEGTTPLASMPVSTTLVVSSEANTLSTTPVDSKTQVATSTEASSPPPTAEVTSMPTS 1212
Query: 2246 SSGYSSPTTSEMSIKDSPSQHSGRPSPGCDSQTSQLDQPLFKLKYPSSPYSAHISKSPRN 2305
+ G S + M + R +P S+ S L P + SA S SP
Sbjct: 1213 TPGERSTPLTSMPV---------RHTPVASSEASTLSTSPVDTSTPVTT-SAETSSSP-- 1260
Query: 2306 MSPSSGHQSPAGSAPSPALSYSSAGSARSSPADAPDIDKLKMAAIDEKVQAVHNLKMFWQ 2365
+ + G P S S + ++ ++ +P+ L +D K V + ++
Sbjct: 1261 -TTAEGTSLPT-STTSEGSTLLTSIPVSTTLVTSPEASTLLTTPVDTKGPVVTSNEVSSS 1318
Query: 2366 STPQHSTG-PMKIFRGAPGTMTS--------KRDVLSLLNLSPRHNKKEEGVDKLELKEL 2416
TP T P + +TS +S+L+ +P N
Sbjct: 1319 PTPAEGTSMPTSTYSEGRTPLTSIPVNTTLVASSAISILSTTPVDNSTPVTTSTEACSSP 1378
Query: 2417 SLQQHDGAPPKAPPNGHWRTETTSLGSLPLPAGPPATAPARPL 2459
+ + P P G TT L S+P+ P ++ A L
Sbjct: 1379 TTSEGTSMPNSNPSEG-----TTPLTSIPVSTTPVVSSEASTL 1416
Score = 48.9 bits (115), Expect = 6e-05
Identities = 99/449 (22%), Positives = 164/449 (36%), Gaps = 64/449 (14%)
Query: 1941 TELPKRLSLDSSSSLESLASAQSVSNALPL--------------GYQQPPFSPT-GADSI 1985
T +P +L +SS++ S+ S V N+ P+ G P +P+ G +
Sbjct: 1340 TSIPVNTTLVASSAI-SILSTTPVDNSTPVTTSTEACSSPTTSEGTSMPNSNPSEGTTPL 1398
Query: 1986 ASDAISVYSL-SSIASSMSFVSKPEGGSEGGGPGGRQDHDRSKNAYLQRST-----LPRS 2039
S +S + SS AS++S ++ + ST P
Sbjct: 1399 TSIPVSTTPVVSSEASTLSATPVDTSTPGTTSAEATSSPTTAEGISIPTSTPSEGKTPLK 1458
Query: 2040 QLPPQTRPAGNKDEEEYEGFSIISNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVSS 2099
+P P N + + SN P+ T +T S P P + +S S
Sbjct: 1459 SIPVSNTPVANSEASTLSTTPVDSNSPVVT-----STAVS---SSPTPAEGTSIAISTPS 1510
Query: 2100 KGSISTPNSPVKMTLIPSPN----SPFQKVGKLASSDTGESDQSSTETDST---VKSQEE 2152
+GS + + PV T + S S V + ++ S T D T + E
Sbjct: 1511 EGSTALTSIPVSTTTVASSEINSLSTTPAVTSTPVTTYSQASSSPTTADGTSMQTSTYSE 1570
Query: 2153 SNPKLDPQELAQKILEETQSHLIAVERLQRSGGQVSKSNNPEDGVQAP-SSTAVFRASET 2211
+ L ++ ++ ++++ ++ + S QV+ S A SS + SE
Sbjct: 1571 GSTPLTSLPVSTMLVVSSEANTLSTTPID-SKTQVTASTEASSSTTAEGSSMTISTPSEG 1629
Query: 2212 SAF-------SRPVLSHQKSQPSPVTVKPKPP----ARSSSLPKVSSGYSSPTTSEMSIK 2260
S + PV S + S S V P SS P + G S PT++ +
Sbjct: 1630 SPLLTSIPVSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPTPAEGTSMPTSTYTEGR 1689
Query: 2261 DSPSQHSGRPSPGCDSQTSQLDQPLFKLKYP--------SSPYSAHISKSPRNMSPSSGH 2312
+ + R +P S S L P SSP ++ + P N +PS G
Sbjct: 1690 TPLTSITVRTTPVASSAISTLSTTPVDNSTPVTTSTEARSSPTTSEGTSMP-NSTPSEG- 1747
Query: 2313 QSPAGSAP---SPALSYSSAGSARSSPAD 2338
+P S P +P LS S A + ++P D
Sbjct: 1748 TTPLTSIPVSTTPVLS-SEASTLSATPID 1775
Score = 48.1 bits (113), Expect = 1e-04
Identities = 92/403 (22%), Positives = 141/403 (34%), Gaps = 58/403 (14%)
Query: 1944 PKRLSLDSSSSLESLASAQSVSNALPLGYQQP-PFSPTGADSIASDAISVYSLSSIASSM 2002
P +S +SSS + A S+SN+ P G P P + S S S + A+++
Sbjct: 246 PVTISAQASSS-PTTAEGPSLSNSAPSGGSTPLTRMPLSVMLVVSSEASTLSTTPAATNI 304
Query: 2003 SFVSKPEGGSEGGGPGGRQDHDRSKNAYLQRSTLPRSQLPPQTRPAGNKDEEEYEGFSII 2062
++ E S P + + Y + ST P + P T P + S +
Sbjct: 305 PVITSTEASSS---PTTAEGTSIPTSTYTEGST-PLTSTPASTMPVATSE------MSTL 354
Query: 2063 SNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVSSKGSISTPNSPVKMTLIPSPNSPF 2122
S P+ T T + P A M S S+GS N PV L+ S
Sbjct: 355 SITPVDT--STLVTTSTEPSSLPTTAEATSMLTSTLSEGSTPLTNMPVSTILVAS----- 407
Query: 2123 QKVGKLASSDTGESDQSSTETDSTVKSQEESNPKL-DPQELAQKILEETQSHLIAVERLQ 2181
+ + T + ++T T S+ S+P + +A E + L ++
Sbjct: 408 ------SEASTTSTIPVDSKTFVTTASEASSSPTTAEDTSIATSTPSEGSTPLTSM---- 457
Query: 2182 RSGGQVSKSNNPEDGVQAPSSTAVFRASETSAFSR-PVLSHQKSQPSPVTVKPKPPARSS 2240
P ST +SE S S PV S + S P A +
Sbjct: 458 ------------------PVSTTPVASSEASNLSTTPVDSKTQVTTSTEASSSPPTAEVN 499
Query: 2241 SLPKVSSGYSSPTTSEMSIKDSP---SQHSGRPSPGCDSQTSQLDQPLFKLKYPSSPYSA 2297
S+P + S + MS+ P S+ S + D+ T P+ SS +
Sbjct: 500 SMPTSTPSEGSTPLTSMSVSTMPVASSEASTLSTTPVDTST-----PVTTSSEASSSSTT 554
Query: 2298 HISKSPRNMSPSSGHQSPAGSAPSPALSYSSAGSARS-SPADA 2339
S +PS G S L SS S S +PAD+
Sbjct: 555 PEGTSIPTSTPSEGSTPLTNMPVSTRLVVSSEASTTSTTPADS 597
Score = 48.1 bits (113), Expect = 1e-04
Identities = 85/412 (20%), Positives = 152/412 (36%), Gaps = 56/412 (13%)
Query: 1939 DSTELPKRLSLDSSSSLESLASAQSVSNALPLGYQQPPFSPTGADSIASDAISVYSLSSI 1998
+ T +P S + ++ L + VS + ++ S T AD+ S ++ YS +
Sbjct: 2324 EGTSMPTSTSSEGNTPLTRMP----VSTTMVASFETSTLSTTPADT--STPVTTYSQA-- 2375
Query: 1999 ASSMSFVSKPEGGSEGGGPGGRQDHDRSKNAYLQRSTLPRSQLPPQTRPAGNKDEEEYEG 2058
G P D + Y + ST P + +P T P + + +
Sbjct: 2376 ---------------GSSPTTADDTSMPTSTYSEGST-PLTSVPVSTMPVVSSEASTHST 2419
Query: 2059 FSIISNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVSSKGSISTPNSPVKMTLIPSP 2118
+ ++ P+ T E ++ P TA G + S +TP + + ++ P
Sbjct: 2420 TPVDTSTPVTTSTEASSS----------PTTAEGTSIPTSPPSEGTTPLASMPVSTTPVV 2469
Query: 2119 NSPFQKVGKLASS--DTGESDQSSTETDSTVKSQEESNPKLDPQELAQKILEETQSHLIA 2176
+S + G L+++ DT +STE S+ + E+ + +L
Sbjct: 2470 SS---EAGTLSTTPVDTSTPMTTSTEASSSPTTAEDIVVPISTASEGSTLLTSIPVSTTP 2526
Query: 2177 VERLQRSGGQVSKSNNPEDGVQAPSSTAVFRASETSAFSRPVLSHQKSQPS------PVT 2230
V + S + S P D ++ +S TSA + + S+ S PV+
Sbjct: 2527 VASPEAS----TLSTTPVDSNSPVVTSTEISSSATSAEGTSMPTSTYSEGSTPLRSMPVS 2582
Query: 2231 VKPKPPARSSSLPKVSSGYSSPTTSEMSIKDSP------SQHSGRPSPGCDSQTSQLDQP 2284
KP + +S+L S P T+ SP S PS S TS L
Sbjct: 2583 TKPLASSEASTLSTTPVDTSIPVTTSTETSSSPTTAKDTSMPISTPSEVSTSLTSILVST 2642
Query: 2285 LFKLKYPSSPYSAHISKSPRNMSPSSGHQSPAGSAPSPALSYSSAGSARSSP 2336
+ +S S + ++ S+G S +A ++ S+ G RS+P
Sbjct: 2643 MPVASSEASTLSTTPVDTRTLVTTSTGTSSSPTTAEGSSMPTSTPGE-RSTP 2693
Score = 47.4 bits (111), Expect = 2e-04
Identities = 93/461 (20%), Positives = 161/461 (34%), Gaps = 63/461 (13%)
Query: 1941 TELPKRLSLDSSSSLESLASAQSVSNALPLGYQQPPFS-PTGADSIASDAISVYSLSSIA 1999
T P S ++S S + A S+ + P P S P + S ++ S + +
Sbjct: 3367 TSTPVTTSTEASLS-PTTAEGTSIPTSSPSEGTTPLASMPVSTTPVVSSEVNTLSTTPVD 3425
Query: 2000 SSMSFVSKPEGGSEGGGPGGRQDHDRSKNAYLQRSTLPRSQLPPQTRPAGNKDEEEYEGF 2059
S+ + E S P + + + ST P S +P T P + +
Sbjct: 3426 SNTLVTTSTEASSS---PTIAEGTSLPTSTTSEGST-PLSIMPLSTTPVASSEASTLSTT 3481
Query: 2060 SIISNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVSSKGSISTPNSPVKMTLIPSPN 2119
+ ++ P+ T SP + P M S + +GS N PV T + S
Sbjct: 3482 PVDTSTPVTTS--------SPTNSSPTTAEVTSMPTSTAGEGSTPLTNMPVSTTPVASSE 3533
Query: 2120 SPFQKVGKLASSD--TGESDQSSTETDSTVKSQEESNPKLDPQELAQKILEET-----QS 2172
+ + S+ T S SS+ V + S P L +L T ++
Sbjct: 3534 ASTLSTTPVDSNTFVTSSSQASSSPATLQVTTMRMSTPSEGSSSLTTMLLSSTYVTSSEA 3593
Query: 2173 HLIAVERLQRS-----GGQVSKSNNPEDGVQAPSST--------AVFRASETSA------ 2213
+ + RS Q + + P + + P ST + S TS
Sbjct: 3594 STPSTPSVDRSTPVTTSTQSNSTPTPPEVITLPMSTPSEVSTPLTIMPVSTTSVTISEAG 3653
Query: 2214 --------FSRPVLSHQKSQPSPVTVKP------KPPARSSSLPKVSSGYSSPTTSEMSI 2259
S PV++ + SPVT + P S+ L + + T+SE S
Sbjct: 3654 TASTLPVDTSTPVITSTQVSSSPVTPEGTTMPIWTPSEGSTPLTTMPVSTTRVTSSEGST 3713
Query: 2260 KDSPSQHSGRP---SPGCDSQTSQLDQPLFKLKYP----SSPYSAHISKSPRNMSPSSGH 2312
+PS + P S S ++ LD + P + + +S +P P S
Sbjct: 3714 LSTPSVVTSTPVTTSTEAISSSATLDSTTMSVSMPMEISTLGTTILVSTTPVTRFPES-- 3771
Query: 2313 QSPAGSAPSPALSYSSAGSARSSPADAPDIDKLKMAAIDEK 2353
+P+ + ++S ++A SSP + M+ E+
Sbjct: 3772 STPSIPSVYTSMSMTTASEGSSSPTTLEGTTTMPMSTTSER 3812
Score = 45.4 bits (106), Expect = 7e-04
Identities = 65/310 (20%), Positives = 112/310 (36%), Gaps = 37/310 (11%)
Query: 1979 PTGADSIASDAISVYSLSSIASSMSFVSKPEGGSEGGGPGGRQDHDRSKNAYLQRSTLPR 2038
P +AS S S + + +S+ + EG S P + + + ST P
Sbjct: 2875 PVSTTPVASSEASTLSTTPVDTSIPVTTSTEGSSS---PTTAEGTSMPISTPSEVST-PL 2930
Query: 2039 SQLPPQTRPAGNKDEEEYEGFSIISNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVS 2098
+ + T P + + + P+ T E ++ P TA G + +S
Sbjct: 2931 TSILVSTVPVAGSEASTLSTTPVDTRTPVTTSAEASSS----------PTTAEGTSMPIS 2980
Query: 2099 SKGSISTPNSPVKMTLIPSPNSPFQKVGKLASSDTGESDQSSTETDSTVKSQEE-----S 2153
+ G TP + + ++ +P +S + + +DT +STE S+ + E S
Sbjct: 2981 TPGERRTPLTSMSVSTMPVASSEASTLSR-TPADTSTPVTTSTEASSSPTTAEGTGIPIS 3039
Query: 2154 NPKLDPQELAQKILEETQSHLIAVERLQRS----------GGQVSKSNNPEDGVQAPSST 2203
P L + T + L + +VS S P +G P ST
Sbjct: 3040 TPSEGSTPLTSIPVSTTPVAIPEASTLSTTPVDSNSPVVTSTEVSSSPTPAEGTSMPIST 3099
Query: 2204 AVFRASETSAFSRPVLSHQKSQPSPVTVKPKPPARSSSLPKVSSGYSSPTTSEMSIKDSP 2263
+ T PV + + + T+ P S+ + + +SSPTTSE
Sbjct: 3100 --YSEGSTPLTGVPVSTTPVTSSAISTLSTTPVDTSTPVTTSTEAHSSPTTSE-----GT 3152
Query: 2264 SQHSGRPSPG 2273
S + PS G
Sbjct: 3153 SMPTSTPSEG 3162
Score = 44.7 bits (104), Expect = 0.001
Identities = 111/548 (20%), Positives = 193/548 (35%), Gaps = 69/548 (12%)
Query: 1941 TELPKRLSLDSSSSLESLASAQSVSNALPLGYQQPPFS-PTGADSIASDAISVYSLSSIA 1999
T P S ++SSS + S+ + P P + P + S S S +
Sbjct: 538 TSTPVTTSSEASSS-STTPEGTSIPTSTPSEGSTPLTNMPVSTRLVVSSEASTTSTTPAD 596
Query: 2000 SSMSFVSKPEGGSEGGGPGGRQDHDRSKNAYLQRSTLPRSQLPPQTRPAGNKDEEEYEGF 2059
S+ + E S G + Y +R T S + T + +
Sbjct: 597 SNTFVTTSSEASSSSTTAEGTS---MPTSTYSERGTTITS-MSVSTTLVASSEASTLSTT 652
Query: 2060 SIISNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVSSKGSISTPNSPVKMTLIPSPN 2119
+ SN P+ T E ++ + + GT+ M S ++GS + PV TL+ S
Sbjct: 653 PVDSNTPVTTSTEATSSSTTAE------GTS--MPTSTYTEGSTPLTSMPVNTTLVASSE 704
Query: 2120 SPFQKVGKLASSD--TGESDQSSTETDSTVKSQEESNPK-----LDPQELAQKILEETQS 2172
+ + +S T ++ SS+ T + S S P L +++ +L +++
Sbjct: 705 ASTLSTTPVDTSTPVTTSTEASSSPTTADGASMPTSTPSEGSTPLTSMPVSKTLLTSSEA 764
Query: 2173 HLIAVERLQRS-----GGQVSKSNNPEDGVQAPSSTAVFRASETSAFSRPVLSHQKSQPS 2227
++ L S + S S +G P ST SE S P+L+
Sbjct: 765 STLSTTPLDTSTHITTSTEASCSPTTTEGTSMPISTP----SEGS----PLLTS-----I 811
Query: 2228 PVTVKPKPPARSSSLPKVSSGYSSPTTSEMSIKDSPSQHSGRPSPG---CDSQTSQLDQP 2284
PV++ P +S+L +SP T+ + SP+ G P + +T P
Sbjct: 812 PVSITPVTSPEASTLSTTPVDSNSPVTTSTEVSSSPTPAEGTSMPTSTYSEGRTPLTSMP 871
Query: 2285 LFKLKYPSSPYSAHISKSPRNMSPSSGHQSPAGSAPSPALSYSSAGSARSSPADAPDIDK 2344
+ +S S +S +P + S + + A S+P+ +S G+ S P P
Sbjct: 872 VSTTLVATSAIST-LSTTPVDTSTPVTNSTEARSSPT-----TSEGT--SMPTSTPGEGS 923
Query: 2345 LKMAAI-DEKVQAVHNLKMFWQSTPQHSTGPMKIFRGAPG-----------TMTSKRDVL 2392
+ ++ D V + +TP ++ P+ A T T
Sbjct: 924 TPLTSMPDSTTPVVSSEARTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTPSEGTT 983
Query: 2393 SLLNLSPRH----NKKEEGVDKLELKE---LSLQQHDGAPPKAPPNGHWRTETTSLGSLP 2445
L + H N + + + L+ +PP T T S GS P
Sbjct: 984 PLTSTPVSHTLVANSEASTLSTTPVDSNTPLTTSTEASSPPPTAEGTSMPTSTPSEGSTP 1043
Query: 2446 LPAGPPAT 2453
L P +T
Sbjct: 1044 LTRMPVST 1051
Score = 44.3 bits (103), Expect = 0.002
Identities = 79/369 (21%), Positives = 135/369 (36%), Gaps = 44/369 (11%)
Query: 1941 TELPKRLSLDSSSSLESLASAQSVSNALPLGYQQPPFSPTGADSIASDAISVYS-----L 1995
T +P + +SS + SL++ +V++ Y Q SPT AD S S YS L
Sbjct: 1517 TSIPVSTTTVASSEINSLSTTPAVTSTPVTTYSQASSSPTTADG-TSMQTSTYSEGSTPL 1575
Query: 1996 SSIASSMSFVSKPEGGSEGGGPGGRQDH-----DRSKNAYLQRSTLPRS----------Q 2040
+S+ S V E + P + + S + + S++ S
Sbjct: 1576 TSLPVSTMLVVSSEANTLSTTPIDSKTQVTASTEASSSTTAEGSSMTISTPSEGSPLLTS 1635
Query: 2041 LPPQTRPAGNKDEEEYEGFSIISNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVSSK 2100
+P T P + + + SN P+ T E ++ P P M S ++
Sbjct: 1636 IPVSTTPVASPEASTLSTTPVDSNSPVITSTEVSSS--------PTPAEGTSMPTSTYTE 1687
Query: 2101 GSISTPNSPVKMTLIPSPNSPFQKVGKLASSDTGESDQSSTETDSTVKSQEESNPKLDPQ 2160
G TP + + + P +S + ++ S+ S S+ S P P
Sbjct: 1688 G--RTPLTSITVRTTPVASSAISTLSTTPVDNSTPVTTSTEARSSPTTSEGTSMPNSTPS 1745
Query: 2161 ELAQKI--LEETQSHLIAVERLQRSGGQVSKSNNPEDGVQAPSS--TAVFRASETSAFSR 2216
E + + + + +++ E S + S +A SS TA + TS S
Sbjct: 1746 EGTTPLTSIPVSTTPVLSSEASTLSATPIDTSTPVTTSTEATSSPTTAEGTSIPTSTLSE 1805
Query: 2217 PVLSHQKSQPSPVTVKPKPPARSSSLPKVSSGYSSPTTSEMSIKDSPSQHSG------RP 2270
++ S P T+ A + S V S +SP + ++ SP+ G P
Sbjct: 1806 G-MTPLTSTPVSHTLVANSEASTLSTTPVDS--NSPVVTSTAVSSSPTPAEGTSIATSTP 1862
Query: 2271 SPGCDSQTS 2279
S G + TS
Sbjct: 1863 SEGSTALTS 1871
Score = 44.3 bits (103), Expect = 0.002
Identities = 85/398 (21%), Positives = 155/398 (38%), Gaps = 41/398 (10%)
Query: 1941 TELPKRLSLDSSSSLESLASAQSVSNALPLGYQQPPFSPTGAD-SIASDAISVYSLSSIA 1999
T P S ++SSS + A S+ + P P S + +AS S S +++
Sbjct: 2719 TSTPVTTSAEASSS-PTTAEGTSMRISTPSDGSTPLTSILVSTLPVASSEASTVSTTAVD 2777
Query: 2000 SSMSFVSKPEGGSEGGGPGGRQDHDRSKNAYLQRSTLPRSQLPPQTRPAGNKDEEEYEGF 2059
+S+ + E S P + + + ST P + +P P + +
Sbjct: 2778 TSIPVTTSTEASSS---PTTAEVTSMPTSTPSETST-PLTSMPVNHTPVASSEAGTLSTT 2833
Query: 2060 SIISNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVS--SKGSISTPNSPVKMTLIPS 2117
+ ++ P+ T + ++ P TA G+ V +S S+GS + PV T + S
Sbjct: 2834 PVDTSTPVTTSTKASSS----------PTTAEGIVVPISTASEGSTLLTSIPVSTTPVAS 2883
Query: 2118 PNSPFQKVGKLASSDTGESDQSSTETDSTVKSQE-ESNPKLDPQELAQKILEETQSHLIA 2176
+ + DT +STE S+ + E S P P E++ + I
Sbjct: 2884 SEASTLSTTPV---DTSIPVTTSTEGSSSPTTAEGTSMPISTPSEVSTPLTS------IL 2934
Query: 2177 VERLQRSGGQVSK-SNNPEDGVQAPSSTAVFRASETSA------FSRPVLSHQKSQPSPV 2229
V + +G + S S P D +++A +S T+A S P V
Sbjct: 2935 VSTVPVAGSEASTLSTTPVDTRTPVTTSAEASSSPTTAEGTSMPISTPGERRTPLTSMSV 2994
Query: 2230 TVKPKPPARSSSLPKVSSGYSSPTTSEMSIKDSPSQHSGRPSPGCDSQTSQLDQPLFKLK 2289
+ P + +S+L + + S+P T+ SP+ G P S S+ PL +
Sbjct: 2995 STMPVASSEASTLSRTPADTSTPVTTSTEASSSPTTAEGTGIP--ISTPSEGSTPLTSIP 3052
Query: 2290 YPSSPY----SAHISKSPRNMSPSSGHQSPAGSAPSPA 2323
++P ++ +S +P + + + S+P+PA
Sbjct: 3053 VSTTPVAIPEASTLSTTPVDSNSPVVTSTEVSSSPTPA 3090
Score = 40.0 bits (92), Expect = 0.029
Identities = 83/414 (20%), Positives = 150/414 (36%), Gaps = 52/414 (12%)
Query: 1941 TELPKRLSLDSSSSLESLASAQSVSNALPLGYQQPPFSPTGADSIASDAISVYSLSSIAS 2000
T +P + +SS +L++ + ++ Y Q SP AD + + S+ +
Sbjct: 3284 TSMPVSTTTVASSETSTLSTTPADTSTPVTTYSQASSSPPIADGTSMPTSTYSEGSTPLT 3343
Query: 2001 SMSFVSKPEGGSEGG-----GPGGRQDHDRSKNAYLQRSTLPRSQLPPQTRPAGNKD--E 2053
+MSF + P SE S A L +T + +P + G
Sbjct: 3344 NMSFSTTPVVSSEASTLSTTPVDTSTPVTTSTEASLSPTTAEGTSIPTSSPSEGTTPLAS 3403
Query: 2054 EEYEGFSIISNE--PLATYQENRNTCFSPD-HKQPQPGTAGGMRVSVSSKGSISTPNSPV 2110
++S+E L+T + NT + P A G + S+ STP
Sbjct: 3404 MPVSTTPVVSSEVNTLSTTPVDSNTLVTTSTEASSSPTIAEGTSLPTSTTSEGSTP---- 3459
Query: 2111 KMTLIPSPNSPFQKVGKLASSDTGESDQSSTETDSTVKSQEESNPKLDPQELAQKILEET 2170
++++P +P +ASS+ + +T + V + +N T
Sbjct: 3460 -LSIMPLSTTP------VASSEASTLSTTPVDTSTPVTTSSPTNS------------SPT 3500
Query: 2171 QSHLIAVERLQRSGGQVSKSNNPEDGVQAPSSTAVFRASETSAFSRPVLSHQKSQPSPVT 2230
+ + ++ G +N P SS A ++ + V S ++ SP T
Sbjct: 3501 TAEVTSMPTSTAGEGSTPLTNMPVSTTPVASSEASTLSTTPVDSNTFVTSSSQASSSPAT 3560
Query: 2231 VK------PKPPARSSSLPKVSSGYSSPTTSEMSIKDSPSQHSGRPSPGCDSQTSQLDQP 2284
++ P SSSL + + T+SE S +PS P +Q++ P
Sbjct: 3561 LQVTTMRMSTPSEGSSSLTTMLLSSTYVTSSEASTPSTPSVDRSTPVT-TSTQSNSTPTP 3619
Query: 2285 LFKLKYPSSPYSAHISKSPRNMSPSSGHQSPAGSAPSPALSYSSAGSARSSPAD 2338
+ P S S +P + P S + +++ S AG+A + P D
Sbjct: 3620 PEVITLPMSTPSE--VSTPLTIMPVS----------TTSVTISEAGTASTLPVD 3661
Score = 39.3 bits (90), Expect = 0.049
Identities = 96/498 (19%), Positives = 163/498 (32%), Gaps = 51/498 (10%)
Query: 1941 TELPKRLSLDSSSSLESLASAQSVSNALPLGYQQPPFS-PTGADSIASDAISVYSLSSIA 1999
T P S + SSS + A S+ + P P P + S + S + +
Sbjct: 2012 TSTPATTSTEGSSS-PTTAGGTSIQTSTPSERTTPLAGMPVSTTLVVSSEGNTLSTTPVD 2070
Query: 2000 SSMSFVSKPEGGSEGGGPGGRQDHDRSKNAYLQRSTLPRSQLPPQTRPAGNKDEEEYEGF 2059
S + E S G +++P S P + A +
Sbjct: 2071 SKTQVTNSTEASSSATAEGSSMTISAPSEGSPLLTSIPLSTTPVASPEASTLSTTPVDSN 2130
Query: 2060 SII------SNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVSSKGSISTPNSPVKMT 2113
S + S+ P+ T + T D + P T+ + +V + +IST ++ T
Sbjct: 2131 SPVITSTEVSSSPIPTEGTSMQTSTYSDRRTPL--TSMPVSTTVVASSAISTLSTTPVDT 2188
Query: 2114 LIPSPNSPFQKVGKLASSDTGESDQSSTETDST----------VKSQEESNPKLDPQELA 2163
P NS + S T + +E + V + E S P + +
Sbjct: 2189 STPVTNSTEARSSPTTSEGTSMPTSTPSEGSTPFTSMPVSTMPVVTSEASTLSATPVDTS 2248
Query: 2164 QKILEETQ--SHLIAVERLQRSGGQVSKSNNPEDGVQAPSSTAVFRASETSAFSR-PVLS 2220
+ T+ S E +S+ P + P S + SE S S PV S
Sbjct: 2249 TPVTTSTEATSSPTTAEGTSIPTSTLSEGTTPLTSI--PVSHTLVANSEVSTLSTTPVDS 2306
Query: 2221 HQKSQPSPVTVKPKPPARSSSLPKVSSGYSS------PTTSEMSIKDSPSQHSGRPSPGC 2274
+ S P P A +S+P +S + P ++ M S S P+
Sbjct: 2307 NTPFTTSTEASSPPPTAEGTSMPTSTSSEGNTPLTRMPVSTTMVASFETSTLSTTPADTS 2366
Query: 2275 D-----SQTSQLDQPLFKLKYPSSPY--------SAHISKSPRNMSPSSGHQSPAGSAPS 2321
SQ P+S Y S +S P S +S H + +
Sbjct: 2367 TPVTTYSQAGSSPTTADDTSMPTSTYSEGSTPLTSVPVSTMPVVSSEASTHSTTPVDTST 2426
Query: 2322 PALSYSSAGSA------RSSPADAPDIDKLKMAAIDEKVQAVHNLKM-FWQSTPQHSTGP 2374
P + + A S+ S P P +A++ V + + +TP ++ P
Sbjct: 2427 PVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTPVVSSEAGTLSTTPVDTSTP 2486
Query: 2375 MKIFRGAPGTMTSKRDVL 2392
M A + T+ D++
Sbjct: 2487 MTTSTEASSSPTTAEDIV 2504
Score = 35.8 bits (81), Expect = 0.54
Identities = 115/543 (21%), Positives = 186/543 (34%), Gaps = 65/543 (11%)
Query: 1949 LDSSSSLESLASAQSVSNALPLGYQQPPFSPT-GADSIASDAISVYSLSSIASSMSFVSK 2007
LD+S+ + + A S S G P +P+ G+ + S +S+ ++S +S +
Sbjct: 772 LDTSTHITTSTEA-SCSPTTTEGTSMPISTPSEGSPLLTSIPVSITPVTSPEASTLSTTP 830
Query: 2008 PEGGSE-------GGGPGGRQDHDRSKNAYLQRSTLPRSQLPPQTRPAGNKDEEEYEGFS 2060
+ S P + + Y + T P + +P T S
Sbjct: 831 VDSNSPVTTSTEVSSSPTPAEGTSMPTSTYSEGRT-PLTSMPVSTTLVATS------AIS 883
Query: 2061 IISNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVSSKGSISTPNSPVKMTLIPSPNS 2120
+S P+ T N+ + P T+ G + S+ G STP + + + P +S
Sbjct: 884 TLSTTPVDTSTPVTNST----EARSSPTTSEGTSMPTSTPGEGSTPLTSMPDSTTPVVSS 939
Query: 2121 PFQKVGKLASSDTGESDQSSTE-TDSTVKSQEESNPKLDPQELAQKILEETQSH-LIAVE 2178
+ + DT +STE T S ++ S P P E + SH L+A
Sbjct: 940 EARTL-SATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTPSEGTTPLTSTPVSHTLVANS 998
Query: 2179 RLQRSGGQVSKSNNPEDGVQAPSSTAVFRASETSAFSRPVLSHQKSQPSPVTVKPKPPAR 2238
SN P SS + S P PV+ +
Sbjct: 999 EASTLSTTPVDSNTPLTTSTEASSPPPTAEGTSMPTSTPSEGSTPLTRMPVSTTMVASSE 1058
Query: 2239 SSSLPKVSSGYSSPTTSEMSIKDSPSQHSGRPSPGCDSQTSQLDQPLFKLKYPS----SP 2294
+S+L + S+P T+ S + G P S S+ PL + + S
Sbjct: 1059 TSTLSTTPADTSTPVTTYSQASSSSTTADGTSMP--TSTYSEGSTPLTSVPVSTRLVVSS 1116
Query: 2295 YSAHISKSPRNMSPSSGHQSPAGSAPSPALSYS---SAGSARSSP-ADAP---------D 2341
++ +S +P + S + A S+P+ A S S S ++P A P +
Sbjct: 1117 EASTLSTTPVDTSIPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTLVVSSE 1176
Query: 2342 IDKLKMAAIDEKVQAVHNLKMFWQSTPQHSTGPMKIFRGAPGTMTSKRDVLSLLNLSPRH 2401
+ L +D K Q ST S P P + +R L ++ RH
Sbjct: 1177 ANTLSTTPVDSKTQVA-------TSTEASSPPPTAEVTSMPTSTPGERST-PLTSMPVRH 1228
Query: 2402 NKKEEGVDKLELKELSLQQHDGAPP--------KAPPNGHWR---TETTSLGSLPLPAGP 2450
V E LS D + P +P T TTS GS L + P
Sbjct: 1229 TP----VASSEASTLSTSPVDTSTPVTTSAETSSSPTTAEGTSLPTSTTSEGSTLLTSIP 1284
Query: 2451 PAT 2453
+T
Sbjct: 1285 VST 1287
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94,680,394
Number of Sequences: 37866
Number of extensions: 4560885
Number of successful extensions: 22940
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 103
Number of HSP's successfully gapped in prelim test: 537
Number of HSP's that attempted gapping in prelim test: 18852
Number of HSP's gapped (non-prelim): 3750
length of query: 2481
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2362
effective length of database: 13,741,464
effective search space: 32457337968
effective search space used: 32457337968
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.