Guide to the Human Genome
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Search of human proteins with 221307568

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo
sapiens]
         (1906 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapi...  3857   0.0  
gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapi...  3749   0.0  
gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]            1299   0.0  
gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]           1041   0.0  
gi|29788755 SET binding factor 2 [Homo sapiens]                       137   1e-31
gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]            133   1e-30
gi|44889475 RAB6 interacting protein 1 [Homo sapiens]                 127   1e-28
gi|239735519 SET binding factor 1 [Homo sapiens]                      125   5e-28
gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]              91   1e-17
gi|209863002 MAP-kinase activating death domain-containing prote...    90   2e-17
gi|209862998 MAP-kinase activating death domain-containing prote...    90   2e-17
gi|209862994 MAP-kinase activating death domain-containing prote...    90   2e-17
gi|18860873 MAP-kinase activating death domain-containing protei...    90   2e-17
gi|209862987 MAP-kinase activating death domain-containing prote...    90   2e-17
gi|209862983 MAP-kinase activating death domain-containing prote...    90   2e-17
gi|209862979 MAP-kinase activating death domain-containing prote...    90   2e-17
gi|209862975 MAP-kinase activating death domain-containing prote...    90   2e-17
gi|209862971 MAP-kinase activating death domain-containing prote...    90   2e-17
gi|209571517 MAP-kinase activating death domain-containing prote...    90   2e-17
gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]             86   5e-16
gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo sapi...    83   2e-15
gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapi...    80   2e-14
gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapi...    80   2e-14
gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo sapi...    80   2e-14
gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]             79   3e-14
gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens]    78   7e-14
gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens]    78   7e-14
gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]               76   3e-13
gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo sapi...    75   5e-13
gi|113205087 DENN/MADD domain containing 1C [Homo sapiens]             64   2e-09

>gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapiens]
          Length = 1906

 Score = 3857 bits (10003), Expect = 0.0
 Identities = 1906/1906 (100%), Positives = 1906/1906 (100%)

Query: 1    MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVAKPKEPITDVSVIIKSLGEEVP 60
            MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVAKPKEPITDVSVIIKSLGEEVP
Sbjct: 1    MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVAKPKEPITDVSVIIKSLGEEVP 60

Query: 61   QDYICIDVTPTGLSADLNNGSLVGPQIYLCYRRGRDKPPLTDLGVLYDWKERLKQGCEII 120
            QDYICIDVTPTGLSADLNNGSLVGPQIYLCYRRGRDKPPLTDLGVLYDWKERLKQGCEII
Sbjct: 61   QDYICIDVTPTGLSADLNNGSLVGPQIYLCYRRGRDKPPLTDLGVLYDWKERLKQGCEII 120

Query: 121  QSTPYGRPANISGSTSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFCKVD 180
            QSTPYGRPANISGSTSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFCKVD
Sbjct: 121  QSTPYGRPANISGSTSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFCKVD 180

Query: 181  KNLNNSMWGSAVYLCYKKSVAKTNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGAT 240
            KNLNNSMWGSAVYLCYKKSVAKTNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGAT
Sbjct: 181  KNLNNSMWGSAVYLCYKKSVAKTNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGAT 240

Query: 241  IECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGK 300
            IECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGK
Sbjct: 241  IECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGK 300

Query: 301  SDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPS 360
            SDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPS
Sbjct: 301  SDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPS 360

Query: 361  PQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILI 420
            PQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILI
Sbjct: 361  PQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILI 420

Query: 421  HSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDP 480
            HSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDP
Sbjct: 421  HSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDP 480

Query: 481  PPDVSCVDVDTNTISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLM 540
            PPDVSCVDVDTNTISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLM
Sbjct: 481  PPDVSCVDVDTNTISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLM 540

Query: 541  DLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFA 600
            DLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFA
Sbjct: 541  DLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFA 600

Query: 601  LQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKVDMDKSGEV 660
            LQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKVDMDKSGEV
Sbjct: 601  LQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKVDMDKSGEV 660

Query: 661  RLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQAKKN 720
            RLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQAKKN
Sbjct: 661  RLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQAKKN 720

Query: 721  KLPSKSSSPNSPLPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCLLRHCYGLWFICLPAYV 780
            KLPSKSSSPNSPLPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCLLRHCYGLWFICLPAYV
Sbjct: 721  KLPSKSSSPNSPLPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCLLRHCYGLWFICLPAYV 780

Query: 781  KVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAG 840
            KVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAG
Sbjct: 781  KVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAG 840

Query: 841  IDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVTQFKRALKKHAHLSQTTLS 900
            IDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVTQFKRALKKHAHLSQTTLS
Sbjct: 841  IDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVTQFKRALKKHAHLSQTTLS 900

Query: 901  DGSDLDAVSHGSMDSGHGTHTVEQAPFNTGLIKVYATDDRSSTGGQSDLGYNSLSKDEVR 960
            DGSDLDAVSHGSMDSGHGTHTVEQAPFNTGLIKVYATDDRSSTGGQSDLGYNSLSKDEVR
Sbjct: 901  DGSDLDAVSHGSMDSGHGTHTVEQAPFNTGLIKVYATDDRSSTGGQSDLGYNSLSKDEVR 960

Query: 961  RGDTSTEDIQEEKDKKGSDCSSLSESESTKGSADCLPKLSYQNSSSIVRLTGTSNNSAGK 1020
            RGDTSTEDIQEEKDKKGSDCSSLSESESTKGSADCLPKLSYQNSSSIVRLTGTSNNSAGK
Sbjct: 961  RGDTSTEDIQEEKDKKGSDCSSLSESESTKGSADCLPKLSYQNSSSIVRLTGTSNNSAGK 1020

Query: 1021 ISGESMESTPELLLISSLEDTNETRNIQSRCFRKRHKSDNETNLQQQVVWGNRNRNLSGG 1080
            ISGESMESTPELLLISSLEDTNETRNIQSRCFRKRHKSDNETNLQQQVVWGNRNRNLSGG
Sbjct: 1021 ISGESMESTPELLLISSLEDTNETRNIQSRCFRKRHKSDNETNLQQQVVWGNRNRNLSGG 1080

Query: 1081 VLMGFMLNRINQEATPGDIVEKLGADAKILSNVISKSTRPNTLDIGKPPLRSKRDSLEKE 1140
            VLMGFMLNRINQEATPGDIVEKLGADAKILSNVISKSTRPNTLDIGKPPLRSKRDSLEKE
Sbjct: 1081 VLMGFMLNRINQEATPGDIVEKLGADAKILSNVISKSTRPNTLDIGKPPLRSKRDSLEKE 1140

Query: 1141 SSDDDTPFDGSNYLADKVDSPVIFDLEDLDSETDVSKAGCVATQNPKRIQRMNSSFSVKP 1200
            SSDDDTPFDGSNYLADKVDSPVIFDLEDLDSETDVSKAGCVATQNPKRIQRMNSSFSVKP
Sbjct: 1141 SSDDDTPFDGSNYLADKVDSPVIFDLEDLDSETDVSKAGCVATQNPKRIQRMNSSFSVKP 1200

Query: 1201 FEKTDVATGFDPLSLLVAETEQQQKEEEEEDEDDSKSISTPSARRDLAEEIVMYMNNMSS 1260
            FEKTDVATGFDPLSLLVAETEQQQKEEEEEDEDDSKSISTPSARRDLAEEIVMYMNNMSS
Sbjct: 1201 FEKTDVATGFDPLSLLVAETEQQQKEEEEEDEDDSKSISTPSARRDLAEEIVMYMNNMSS 1260

Query: 1261 PLTSRTPSIDLQRACDDKLNKKSPPLVKACRRSSLPPNSPKPVRLTKSKSYTKSEEKPRD 1320
            PLTSRTPSIDLQRACDDKLNKKSPPLVKACRRSSLPPNSPKPVRLTKSKSYTKSEEKPRD
Sbjct: 1261 PLTSRTPSIDLQRACDDKLNKKSPPLVKACRRSSLPPNSPKPVRLTKSKSYTKSEEKPRD 1320

Query: 1321 RLWSSPAFSPTCPFREESQDTLTHSSPSFNLDTLLVPKLDVLRNSMFTAGKGVAEKASKW 1380
            RLWSSPAFSPTCPFREESQDTLTHSSPSFNLDTLLVPKLDVLRNSMFTAGKGVAEKASKW
Sbjct: 1321 RLWSSPAFSPTCPFREESQDTLTHSSPSFNLDTLLVPKLDVLRNSMFTAGKGVAEKASKW 1380

Query: 1381 YSRFTMYTTSSKDQSSDRTSLSSVGAQDSESTSLTDEDVCHELEGPISSQETSATSGTKR 1440
            YSRFTMYTTSSKDQSSDRTSLSSVGAQDSESTSLTDEDVCHELEGPISSQETSATSGTKR
Sbjct: 1381 YSRFTMYTTSSKDQSSDRTSLSSVGAQDSESTSLTDEDVCHELEGPISSQETSATSGTKR 1440

Query: 1441 IDLSRISLESSASLEGSLSKFALPGKSEVTSSFNASNTNIFQNYAMEVLISSCSRCRTCD 1500
            IDLSRISLESSASLEGSLSKFALPGKSEVTSSFNASNTNIFQNYAMEVLISSCSRCRTCD
Sbjct: 1441 IDLSRISLESSASLEGSLSKFALPGKSEVTSSFNASNTNIFQNYAMEVLISSCSRCRTCD 1500

Query: 1501 CLVHDEEIMAGWTADDSNLNTTCPFCGNIFLPFLNIEIRDLRRPGRYFLKSSPSTENMHF 1560
            CLVHDEEIMAGWTADDSNLNTTCPFCGNIFLPFLNIEIRDLRRPGRYFLKSSPSTENMHF
Sbjct: 1501 CLVHDEEIMAGWTADDSNLNTTCPFCGNIFLPFLNIEIRDLRRPGRYFLKSSPSTENMHF 1560

Query: 1561 PSSISSQTRQSCISTSASGLDTSALSVQGNFDLNSKSKLQENFCTRSIQIPANRSKTAMS 1620
            PSSISSQTRQSCISTSASGLDTSALSVQGNFDLNSKSKLQENFCTRSIQIPANRSKTAMS
Sbjct: 1561 PSSISSQTRQSCISTSASGLDTSALSVQGNFDLNSKSKLQENFCTRSIQIPANRSKTAMS 1620

Query: 1621 KCPIFPMARSISTSGPLDKEDTGRQKLISTGSLPATLQGATDSLGLEWHLPSPDPVTVPY 1680
            KCPIFPMARSISTSGPLDKEDTGRQKLISTGSLPATLQGATDSLGLEWHLPSPDPVTVPY
Sbjct: 1621 KCPIFPMARSISTSGPLDKEDTGRQKLISTGSLPATLQGATDSLGLEWHLPSPDPVTVPY 1680

Query: 1681 LSPLVVWKELESLLENEGDHAITVADFVDHHPIVFWNLVWYFRRLDLPSNLPGLILSSEH 1740
            LSPLVVWKELESLLENEGDHAITVADFVDHHPIVFWNLVWYFRRLDLPSNLPGLILSSEH
Sbjct: 1681 LSPLVVWKELESLLENEGDHAITVADFVDHHPIVFWNLVWYFRRLDLPSNLPGLILSSEH 1740

Query: 1741 CNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWNAHTQKYPMVHLLQKSDN 1800
            CNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWNAHTQKYPMVHLLQKSDN
Sbjct: 1741 CNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWNAHTQKYPMVHLLQKSDN 1800

Query: 1801 SFNQELLKSMVKSIKMNDVYGPMSQILETLNKCPHFKRQRSLYREILFLSLVALGRENID 1860
            SFNQELLKSMVKSIKMNDVYGPMSQILETLNKCPHFKRQRSLYREILFLSLVALGRENID
Sbjct: 1801 SFNQELLKSMVKSIKMNDVYGPMSQILETLNKCPHFKRQRSLYREILFLSLVALGRENID 1860

Query: 1861 IDAFDKEYKMAYDRLTPSQVKSTHNCDRPPSTGVMECRKTFGEPYL 1906
            IDAFDKEYKMAYDRLTPSQVKSTHNCDRPPSTGVMECRKTFGEPYL
Sbjct: 1861 IDAFDKEYKMAYDRLTPSQVKSTHNCDRPPSTGVMECRKTFGEPYL 1906


>gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapiens]
          Length = 1863

 Score = 3749 bits (9723), Expect = 0.0
 Identities = 1863/1906 (97%), Positives = 1863/1906 (97%), Gaps = 43/1906 (2%)

Query: 1    MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVAKPKEPITDVSVIIKSLGEEVP 60
            MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVAKPKEPITDVSVIIKSLGEEVP
Sbjct: 1    MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVAKPKEPITDVSVIIKSLGEEVP 60

Query: 61   QDYICIDVTPTGLSADLNNGSLVGPQIYLCYRRGRDKPPLTDLGVLYDWKERLKQGCEII 120
            QDYICIDVTPTGLSADLNNGSLVGPQIYLCYRRGRDKPPLTDLGVLYDWKERLKQGCEII
Sbjct: 61   QDYICIDVTPTGLSADLNNGSLVGPQIYLCYRRGRDKPPLTDLGVLYDWKERLKQGCEII 120

Query: 121  QSTPYGRPANISGSTSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFCKVD 180
            QSTPYGRPANISGSTSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFCKVD
Sbjct: 121  QSTPYGRPANISGSTSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFCKVD 180

Query: 181  KNLNNSMWGSAVYLCYKKSVAKTNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGAT 240
            KNLNNSMWGSAVYLCYKKSVAKTNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGAT
Sbjct: 181  KNLNNSMWGSAVYLCYKKSVAKTNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGAT 240

Query: 241  IECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGK 300
            IECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGK
Sbjct: 241  IECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGK 300

Query: 301  SDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPS 360
            SDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPS
Sbjct: 301  SDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPS 360

Query: 361  PQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILI 420
            PQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILI
Sbjct: 361  PQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILI 420

Query: 421  HSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDP 480
            HSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDP
Sbjct: 421  HSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDP 480

Query: 481  PPDVSCVDVDTNTISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLM 540
            PPDVSCVDVDTNTISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLM
Sbjct: 481  PPDVSCVDVDTNTISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLM 540

Query: 541  DLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFA 600
            DLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFA
Sbjct: 541  DLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFA 600

Query: 601  LQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKVDMDKSGEV 660
            LQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKVDMDKSGEV
Sbjct: 601  LQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKVDMDKSGEV 660

Query: 661  RLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQAKKN 720
            RLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQAKKN
Sbjct: 661  RLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQAKKN 720

Query: 721  KLPSKSSSPNSPLPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCLLRHCYGLWFICLPAYV 780
            KLPSKSSSPNSPLPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCLLRHCYGLWFICLPAYV
Sbjct: 721  KLPSKSSSPNSPLPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCLLRHCYGLWFICLPAYV 780

Query: 781  KVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAG 840
            KVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAG
Sbjct: 781  KVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAG 840

Query: 841  IDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVTQFKRALKKHAHLSQTTLS 900
            IDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVTQFKRALKKHAHLSQTTLS
Sbjct: 841  IDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVTQFKRALKKHAHLSQTTLS 900

Query: 901  DGSDLDAVSHGSMDSGHGTHTVEQAPFNTGLIKVYATDDRSSTGGQSDLGYNSLSKDEVR 960
                                                       GGQSDLGYNSLSKDEVR
Sbjct: 901  -------------------------------------------GGQSDLGYNSLSKDEVR 917

Query: 961  RGDTSTEDIQEEKDKKGSDCSSLSESESTKGSADCLPKLSYQNSSSIVRLTGTSNNSAGK 1020
            RGDTSTEDIQEEKDKKGSDCSSLSESESTKGSADCLPKLSYQNSSSIVRLTGTSNNSAGK
Sbjct: 918  RGDTSTEDIQEEKDKKGSDCSSLSESESTKGSADCLPKLSYQNSSSIVRLTGTSNNSAGK 977

Query: 1021 ISGESMESTPELLLISSLEDTNETRNIQSRCFRKRHKSDNETNLQQQVVWGNRNRNLSGG 1080
            ISGESMESTPELLLISSLEDTNETRNIQSRCFRKRHKSDNETNLQQQVVWGNRNRNLSGG
Sbjct: 978  ISGESMESTPELLLISSLEDTNETRNIQSRCFRKRHKSDNETNLQQQVVWGNRNRNLSGG 1037

Query: 1081 VLMGFMLNRINQEATPGDIVEKLGADAKILSNVISKSTRPNTLDIGKPPLRSKRDSLEKE 1140
            VLMGFMLNRINQEATPGDIVEKLGADAKILSNVISKSTRPNTLDIGKPPLRSKRDSLEKE
Sbjct: 1038 VLMGFMLNRINQEATPGDIVEKLGADAKILSNVISKSTRPNTLDIGKPPLRSKRDSLEKE 1097

Query: 1141 SSDDDTPFDGSNYLADKVDSPVIFDLEDLDSETDVSKAGCVATQNPKRIQRMNSSFSVKP 1200
            SSDDDTPFDGSNYLADKVDSPVIFDLEDLDSETDVSKAGCVATQNPKRIQRMNSSFSVKP
Sbjct: 1098 SSDDDTPFDGSNYLADKVDSPVIFDLEDLDSETDVSKAGCVATQNPKRIQRMNSSFSVKP 1157

Query: 1201 FEKTDVATGFDPLSLLVAETEQQQKEEEEEDEDDSKSISTPSARRDLAEEIVMYMNNMSS 1260
            FEKTDVATGFDPLSLLVAETEQQQKEEEEEDEDDSKSISTPSARRDLAEEIVMYMNNMSS
Sbjct: 1158 FEKTDVATGFDPLSLLVAETEQQQKEEEEEDEDDSKSISTPSARRDLAEEIVMYMNNMSS 1217

Query: 1261 PLTSRTPSIDLQRACDDKLNKKSPPLVKACRRSSLPPNSPKPVRLTKSKSYTKSEEKPRD 1320
            PLTSRTPSIDLQRACDDKLNKKSPPLVKACRRSSLPPNSPKPVRLTKSKSYTKSEEKPRD
Sbjct: 1218 PLTSRTPSIDLQRACDDKLNKKSPPLVKACRRSSLPPNSPKPVRLTKSKSYTKSEEKPRD 1277

Query: 1321 RLWSSPAFSPTCPFREESQDTLTHSSPSFNLDTLLVPKLDVLRNSMFTAGKGVAEKASKW 1380
            RLWSSPAFSPTCPFREESQDTLTHSSPSFNLDTLLVPKLDVLRNSMFTAGKGVAEKASKW
Sbjct: 1278 RLWSSPAFSPTCPFREESQDTLTHSSPSFNLDTLLVPKLDVLRNSMFTAGKGVAEKASKW 1337

Query: 1381 YSRFTMYTTSSKDQSSDRTSLSSVGAQDSESTSLTDEDVCHELEGPISSQETSATSGTKR 1440
            YSRFTMYTTSSKDQSSDRTSLSSVGAQDSESTSLTDEDVCHELEGPISSQETSATSGTKR
Sbjct: 1338 YSRFTMYTTSSKDQSSDRTSLSSVGAQDSESTSLTDEDVCHELEGPISSQETSATSGTKR 1397

Query: 1441 IDLSRISLESSASLEGSLSKFALPGKSEVTSSFNASNTNIFQNYAMEVLISSCSRCRTCD 1500
            IDLSRISLESSASLEGSLSKFALPGKSEVTSSFNASNTNIFQNYAMEVLISSCSRCRTCD
Sbjct: 1398 IDLSRISLESSASLEGSLSKFALPGKSEVTSSFNASNTNIFQNYAMEVLISSCSRCRTCD 1457

Query: 1501 CLVHDEEIMAGWTADDSNLNTTCPFCGNIFLPFLNIEIRDLRRPGRYFLKSSPSTENMHF 1560
            CLVHDEEIMAGWTADDSNLNTTCPFCGNIFLPFLNIEIRDLRRPGRYFLKSSPSTENMHF
Sbjct: 1458 CLVHDEEIMAGWTADDSNLNTTCPFCGNIFLPFLNIEIRDLRRPGRYFLKSSPSTENMHF 1517

Query: 1561 PSSISSQTRQSCISTSASGLDTSALSVQGNFDLNSKSKLQENFCTRSIQIPANRSKTAMS 1620
            PSSISSQTRQSCISTSASGLDTSALSVQGNFDLNSKSKLQENFCTRSIQIPANRSKTAMS
Sbjct: 1518 PSSISSQTRQSCISTSASGLDTSALSVQGNFDLNSKSKLQENFCTRSIQIPANRSKTAMS 1577

Query: 1621 KCPIFPMARSISTSGPLDKEDTGRQKLISTGSLPATLQGATDSLGLEWHLPSPDPVTVPY 1680
            KCPIFPMARSISTSGPLDKEDTGRQKLISTGSLPATLQGATDSLGLEWHLPSPDPVTVPY
Sbjct: 1578 KCPIFPMARSISTSGPLDKEDTGRQKLISTGSLPATLQGATDSLGLEWHLPSPDPVTVPY 1637

Query: 1681 LSPLVVWKELESLLENEGDHAITVADFVDHHPIVFWNLVWYFRRLDLPSNLPGLILSSEH 1740
            LSPLVVWKELESLLENEGDHAITVADFVDHHPIVFWNLVWYFRRLDLPSNLPGLILSSEH
Sbjct: 1638 LSPLVVWKELESLLENEGDHAITVADFVDHHPIVFWNLVWYFRRLDLPSNLPGLILSSEH 1697

Query: 1741 CNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWNAHTQKYPMVHLLQKSDN 1800
            CNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWNAHTQKYPMVHLLQKSDN
Sbjct: 1698 CNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWNAHTQKYPMVHLLQKSDN 1757

Query: 1801 SFNQELLKSMVKSIKMNDVYGPMSQILETLNKCPHFKRQRSLYREILFLSLVALGRENID 1860
            SFNQELLKSMVKSIKMNDVYGPMSQILETLNKCPHFKRQRSLYREILFLSLVALGRENID
Sbjct: 1758 SFNQELLKSMVKSIKMNDVYGPMSQILETLNKCPHFKRQRSLYREILFLSLVALGRENID 1817

Query: 1861 IDAFDKEYKMAYDRLTPSQVKSTHNCDRPPSTGVMECRKTFGEPYL 1906
            IDAFDKEYKMAYDRLTPSQVKSTHNCDRPPSTGVMECRKTFGEPYL
Sbjct: 1818 IDAFDKEYKMAYDRLTPSQVKSTHNCDRPPSTGVMECRKTFGEPYL 1863


>gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]
          Length = 1673

 Score = 1299 bits (3361), Expect = 0.0
 Identities = 782/1756 (44%), Positives = 1058/1756 (60%), Gaps = 169/1756 (9%)

Query: 237  MGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTS 296
            MGATIECW   +KYPLPVFSTFVLTG+SA+KVYGAAIQFYEPYS E L+EKQ + LGL +
Sbjct: 1    MGATIECWDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMHLGLLT 60

Query: 297  ADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKV 356
               +   SK+I+TNKCICLLSHWPFF+AFRKFL F+Y+ S+SGPH LPIEKHISHFM  +
Sbjct: 61   PVERKMVSKSINTNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNI 120

Query: 357  PFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEH 416
            PFPSPQRPRILVQLS HD LILSQPVS+PLPLSG  FSTLL NLGPEN  TLL+F + E 
Sbjct: 121  PFPSPQRPRILVQLSVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLES 180

Query: 417  KILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFD 476
            KIL+HSLRP+VLT V EA+V+MIFPF W CPY+PLCPL+LA VLSAP PFIVG+DSRYFD
Sbjct: 181  KILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRYFD 240

Query: 477  LYDPPPDVSCVDVDTNTISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRD 536
            L+DPP DV C+D+DTN +    +KKN+ WK LPKKPCKNL++TL  L+ QL+ + Q+ ++
Sbjct: 241  LHDPPQDVVCIDLDTNMLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQE 300

Query: 537  DGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAA 596
               +D+   + DF+  K++  +++EIQEAFL FMASILKGYR+YLRPIT+APS  AT A 
Sbjct: 301  GSAIDMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAAD 360

Query: 597  SLFALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCV------- 649
            SLF  Q FL+SRDR++ KFY +++KTQ+FIRFIEECSFVSDKD  LAFFDDC+       
Sbjct: 361  SLFDRQGFLKSRDRAYAKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEKLFPDK 420

Query: 650  -----DKVDMDKSGEVRLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLR 704
                 DKVD D + + RLIELD+S KSEHTVF+ PPE P   +G++   +YSY  FP L 
Sbjct: 421  GTEKTDKVDFDSAEDTRLIELDDSQKSEHTVFIMPPE-PPPDDGKDLSPKYSYKYFPRLD 479

Query: 705  NNLFERPEGFLQAKKNKLPSKSSSPNSPLPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCL 764
              LF+RP+  L+   ++ P+ +S   SP  M +RTKQEIK+AHK+AKR  + P  W++CL
Sbjct: 480  LKLFDRPQE-LKLCFSRHPTGNSITKSPPLMAKRTKQEIKTAHKLAKRCYTNPPQWAKCL 538

Query: 765  LRHCYGLWFICLPAYVKVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYD 824
              HCY LWFICLPAYV+V H KVRAL+ AYDVL KM+   +DP DEVCYR++MQLCG + 
Sbjct: 539  FSHCYSLWFICLPAYVRVSHPKVRALQQAYDVLIKMRKTDVDPLDEVCYRVVMQLCGLWG 598

Query: 825  QPVLAVRVLFEMQKAGIDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVTQF 884
             PVLAVRVLFEM+ A I PNAITYGYYNK VLES WPS +RSG FLWTKVRNVV G+ QF
Sbjct: 599  HPVLAVRVLFEMKTARIKPNAITYGYYNKVVLESPWPSSTRSGIFLWTKVRNVVRGLAQF 658

Query: 885  KRALKKHAHLSQTTLSDGSDLDAVSHGSMDSGHGTHTVEQAPFNTGLIKVYATDDRSSTG 944
            ++ LKK    SQ        + ++S G  D G+G                 + D+     
Sbjct: 659  RQPLKKTVQRSQ--------VSSISGGQSDQGYG-----------------SKDELIKDD 693

Query: 945  GQSDLGYNSLSKDEVRRGDTSTEDIQEEKDKKGSDCSSLSESESTKGSADCLPKLSYQNS 1004
             +  +     +++ + +    TE++         D S++    S        P       
Sbjct: 694  AEIHVPEEQAARELITKTKMQTEEV--------CDASAIVAKHSQPSPEPHSPTEPPAWG 745

Query: 1005 SSIVRL-TGTSNNSAGKISGESMESTPELLLISSLEDTNETRNIQSRCFRKRHKSDNETN 1063
            SSIV++ +G  + ++ K S  S+ +     ++ S +D  E          K++    E  
Sbjct: 746  SSIVKVPSGIFDVNSRKSSTGSISN-----VLFSTQDPVEDAVFGEATNLKKNGDRGE-- 798

Query: 1064 LQQQVVWGNRNRNLSGGVLMGFMLNRINQEATPGDIVEKLGADAKILSNVISKSTRPNTL 1123
             ++Q  +  R+ + S     G +L + + ++   ++   +GADAKIL+  ++   + + L
Sbjct: 799  -KRQKHFPERSCSFSSESRAGMLLKKSSLDSNSSEMAIMMGADAKILTAALT-CPKTSLL 856

Query: 1124 DIGK-----------PPLRSKRDSLEKESSDDDTPFDGSNYLADKVDSPVIFDL------ 1166
             I +           P  R+             +P       + ++  PV+ D+      
Sbjct: 857  HIARTHSFENVSCHLPDSRTCMSESTWNPEHRSSPVPEMLEESQELLEPVVDDVPKTTAT 916

Query: 1167 ----EDLDSETDVSKAGCVATQNPKRIQRMNSSFSV-KPFEKTDVATGFDPLSLLVAETE 1221
                E L S+++ +++  + T +     + +S + + K  ++ DV TG DPLSLL  E  
Sbjct: 917  VDTYESLLSDSNSNQSRDLKTVSKDLRNKRSSLYGIAKVVQREDVETGLDPLSLLATECT 976

Query: 1222 QQQKEEEEEDEDDSKSISTPSARRDLAEEIVMYMNNMSSPLTSRTPSIDLQRACDDKLNK 1281
              +  + E+       + +P   R+LA+EI  YM N+ SPL S++ S++L R  + +   
Sbjct: 977  GGKTPDSED------KLFSPVIARNLADEIESYM-NLKSPLGSKSSSMELHREENRESGM 1029

Query: 1282 KSPPLVKACRRSSLPPNSPKPVR-----------LTKSKSYTK--SEEKP----RDRLWS 1324
             +  +    RRSSLP +   P +           +++SK++T    ++ P    ++R  S
Sbjct: 1030 TTAFIHALERRSSLPLDHGSPAQENPESEKSSPAVSRSKTFTGRFKQQTPSRTHKERSTS 1089

Query: 1325 SPAFSPTCPFREESQDTLTHSSPSFNLDTLLV-PKLDVLRNSMFTAGKGVAEKASK-WYS 1382
              A   + P    S  ++ +S     LD +L  PK+DVL++ M    K  A  ASK W +
Sbjct: 1090 LSALVRSSP--HGSLGSVVNSLSGLKLDNILSGPKIDVLKSGM----KQAATVASKMWVA 1143

Query: 1383 RFTMYTTSSKDQSSDRTSLSSVGAQDSESTSLTDEDVCHELEGPISSQETSATSGTKRID 1442
              + Y+ S  ++ ++R      G +D            H L   IS   + +      + 
Sbjct: 1144 VASAYSYSDDEEETNRDYSFPAGLED------------HILGENISPNTSISGLVPSELT 1191

Query: 1443 LSRISLESSASLEGSLSKFALP---------------GKSEVTSSFNASNTNIFQNYAME 1487
             S  SL SS+S  G + K   P                KS+  SS N S ++I+QN AME
Sbjct: 1192 QSNTSLGSSSS-SGDVGKLHYPTGEVPFPRGMKGQDFEKSDHGSSQNTSMSSIYQNCAME 1250

Query: 1488 VLISSCSRCRTCDCLVHDEEIMAGWTADDSNLNTTCPFCGNIFLPFLNIEIRDLRRPGRY 1547
            VL+SSCS+CR C  LV+DEEIMAGWTADDSNLNT CPFC + FLP LNIE +DLR    +
Sbjct: 1251 VLMSSCSQCRACGALVYDEEIMAGWTADDSNLNTACPFCKSNFLPLLNIEFKDLRGSASF 1310

Query: 1548 FLKSSPSTENMHFPSSISSQTRQSCISTSASGLDTSALSVQGNFDLNSKSKLQENFCTRS 1607
            FLK  PST      S       +S      S L    L    +F  +++   +E   T S
Sbjct: 1311 FLK--PSTSGDSLQSGSIPLANESLEHKPVSSLAEPDLINFMDFPKHNQIITEE---TGS 1365

Query: 1608 IQIPANRSKTA--------MSKCP------IFPMARSISTSGPLDKEDTGRQKL--ISTG 1651
               P++  K A        +S  P         + RS S  GPL   D  ++    IST 
Sbjct: 1366 AVEPSDEIKRASGDVQTMKISSVPNSLSKRNVSLTRSHSVGGPLQNIDFTQRPFHGISTV 1425

Query: 1652 SLPATLQGATDSLGLEWHLPSPDPVTVPYLSPLVVWKELESLLENEGDHAITVADFVDHH 1711
            SLP +LQ   D LG     P+P PV+VPYLSPLV+ KELESLLENEGD  I  + F++ H
Sbjct: 1426 SLPNSLQEVVDPLGKR---PNPPPVSVPYLSPLVLRKELESLLENEGDQVIHTSSFINQH 1482

Query: 1712 PIVFWNLVWYFRRLDLPSNLPGLILSSEHCNKYSKIPRHCMSEDSKYVLIQMLWDNMKLH 1771
            PI+FWNLVWYFRRLDLPSNLPGLIL+SEHCN+  ++P   +S+DSK V IQ+LWDN+ LH
Sbjct: 1483 PIIFWNLVWYFRRLDLPSNLPGLILTSEHCNEGVQLPLSSLSQDSKLVYIQLLWDNINLH 1542

Query: 1772 QDPGQPLYILW-NAHTQKYPMVHLLQKSDNSFNQELLKSMVKSIKMNDVYGPMSQILETL 1830
            Q+P +PLY+ W N +++K   +   ++ + S    L++++ +SI+ N+V  P++ + + +
Sbjct: 1543 QEPREPLYVSWRNFNSEKKSSLLSEEQQETS---TLVETIRQSIQHNNVLKPINLLSQQM 1599

Query: 1831 NKCPHFKRQRSLYREILFLSLVALGRENIDIDAFDKEYKMAYDRLTPSQVKSTHNCDRPP 1890
               P  KRQRSLYREILFLSLV+LGRENIDI+AFD EY +AY+ L+   ++     D PP
Sbjct: 1600 K--PGMKRQRSLYREILFLSLVSLGRENIDIEAFDNEYGIAYNSLSSEILERLQKIDAPP 1657

Query: 1891 STGVMECRKTFGEPYL 1906
            S  V  CRK FG P +
Sbjct: 1658 SASVEWCRKCFGAPLI 1673


>gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]
          Length = 1496

 Score = 1041 bits (2691), Expect = 0.0
 Identities = 516/906 (56%), Positives = 660/906 (72%), Gaps = 17/906 (1%)

Query: 1   MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVAKPK--EPITDVSVIIKSLGEE 58
           M E++ PR+ DYFVVAGL     P+ EE    +    +  P+  EPITDV+VI ++LGEE
Sbjct: 1   MAEERPPRLVDYFVVAGLAGNGAPIPEETWVPEPSGPLRPPRPAEPITDVAVIARALGEE 60

Query: 59  VPQDYICIDVTPTGLSADLNNGSLVGPQIYLCYRRGRDKPPLTDLGVLYDWKERLKQGCE 118
           VPQ Y CI  +  G   +L+ G L G Q  +CYRRGRDKPPL +LGVLY+ KER K G +
Sbjct: 61  VPQGYTCIQASAGGHPLELSAGLLGGTQPVICYRRGRDKPPLVELGVLYEGKERPKPGFQ 120

Query: 119 IIQSTPYGRPANISG-STSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFC 177
           ++ +TPY   AN++       R Y+TYRRA+E    + L +TD+C+++PSKGE  PHT+C
Sbjct: 121 VLDTTPYSHSANLAPPGPGHPRTYLTYRRAAEGAGLHALGITDLCLVLPSKGEGTPHTYC 180

Query: 178 KVDKNLNNSMWGSAVYLCYKKSVAKTNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPM 237
           ++ +NLN  MWG AVYLCYK  +AK NT+ Y+A L+ RYP+ED E+F LPESVP+FCLPM
Sbjct: 181 RLPRNLNPGMWGPAVYLCYKVGLAKANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPM 240

Query: 238 GATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTSA 297
           GATIECWP+ +KYP+PVFSTFVLTGA+ +KVYGAA+QFYE +    L+E+Q   LGL SA
Sbjct: 241 GATIECWPAQTKYPVPVFSTFVLTGAAGDKVYGAALQFYEAFPRARLSERQARALGLLSA 300

Query: 298 --DGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHK 355
              G++   + + + + I +LS WP F AFR FLTFLYRYS+SGPH LP+E HISHF+H 
Sbjct: 301 VERGRALGGRAVRSRRAIAVLSRWPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIHN 360

Query: 356 VPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTE 415
           VPFPSPQRPRILVQ+SP+DNL+L QPVSSPLPLSG  F  LLQ+LGPE A+TLL+  +TE
Sbjct: 361 VPFPSPQRPRILVQMSPYDNLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTE 420

Query: 416 HKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYF 475
           HK+L+HSLRP +LTSV EALVSMIFP HW CPY+PLCPL LADVLSAP PFIVGI S YF
Sbjct: 421 HKLLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYF 480

Query: 476 DLYDPPPDVSCVDVDTNTISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPR 535
           DL+DPP DV CVD+DTNT+ Q  +KK ++ + LP++P K L+ TL NL+QQL +    P 
Sbjct: 481 DLHDPPADVICVDLDTNTLFQTEEKKLLSPRTLPRRPYKVLLATLTNLYQQLDQTYTGPE 540

Query: 536 DDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDA 595
           ++  ++  + DY+   G+R   ++ E+Q AFL FMA +LKGYR +LRP+TQAPSE A D 
Sbjct: 541 EEASLEFLLTDYEAVCGRRAR-LEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDV 599

Query: 596 ASLFALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKV--D 653
            +LF LQ FL+SR+RS  K Y+ +  TQMF +FIEECSF S + A+L FFD CV+KV  +
Sbjct: 600 DNLFFLQGFLKSRERSSHKLYSQLLHTQMFSQFIEECSFGSARHAALEFFDSCVEKVHPE 659

Query: 654 MDKSGEVRLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLRNNLFERPEG 713
            +K     L+EL+E   SE TVF+TPPE P LP G E   QY Y+GFP LR  LFE    
Sbjct: 660 QEKPEPTPLVELEELSGSELTVFITPPEEPALPEGSESTPQYCYDGFPELRAELFES--- 716

Query: 714 FLQAKKNKLP---SKSSSPNSPLPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCLLRHCYG 770
            LQ +   LP      S+P+SP P  RRTKQE+K A ++A++ +++P++W+RCLL HCYG
Sbjct: 717 -LQEQPGALPVPGPSRSAPSSPAP--RRTKQEMKVAQRMAQKSAAVPELWARCLLGHCYG 773

Query: 771 LWFICLPAYVKVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYDQPVLAV 830
           LWF+CLPAYV+   S+V+AL TAY VL++M+S K+  PDEVCYR+LMQLC  Y QPVL+V
Sbjct: 774 LWFLCLPAYVRSAPSRVQALHTAYHVLRQMESGKVVLPDEVCYRVLMQLCSHYGQPVLSV 833

Query: 831 RVLFEMQKAGIDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVTQFKRALKK 890
           RV+ EM++AGI PN ITYGYYNKAVLES WPS +  G   W K+RNVVLG  QF++ L++
Sbjct: 834 RVMLEMRQAGIVPNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVVLGAAQFRQPLRE 893

Query: 891 HAHLSQ 896
                Q
Sbjct: 894 RQQQQQ 899



 Score =  179 bits (455), Expect = 2e-44
 Identities = 95/228 (41%), Positives = 142/228 (62%), Gaps = 3/228 (1%)

Query: 1680 YLSPLVVWKELESLLENEGDHAITVADFVDHHPIVFWNLVWYFRRLDLPSNLPGLILSSE 1739
            YLSPLV+ KELESL+ENEG   + + +    HPI+FWNL+WYF+RL LPS LPGL+L+S 
Sbjct: 1266 YLSPLVLRKELESLVENEGSEVLALPELPSAHPIIFWNLLWYFQRLRLPSILPGLVLASC 1325

Query: 1740 HCNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWNAHTQKYPMVHLLQKSD 1799
                +S+ P   ++ D   V +++LWD +    +   PLY+LW  H+Q    V       
Sbjct: 1326 DGPSHSQAPSPWLTPDPASVQVRLLWDVLTPDPNSCPPLYVLWRVHSQIPQRVVWPGPVP 1385

Query: 1800 NSFNQELLKSMVKSIKMNDVYGPMSQILETLNKCP-HFKRQRSLYREILFLSLVALGREN 1858
             S +  LL+S+++ + +N+V+  +  +LETL   P     QR +YREILFL++ ALG+++
Sbjct: 1386 ASLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPTGLHLQRGIYREILFLTMAALGKDH 1445

Query: 1859 IDIDAFDKEYKMAYDRLTPSQVKS--THNCDRPPSTGVMECRKTFGEP 1904
            +DI AFDK+YK A+++L  S  K    H   + P+   ++CRK FG P
Sbjct: 1446 VDIVAFDKKYKSAFNKLASSMGKEELRHRRAQMPTPKAIDCRKCFGAP 1493



 Score = 99.4 bits (246), Expect = 3e-20
 Identities = 54/97 (55%), Positives = 67/97 (69%), Gaps = 3/97 (3%)

Query: 1449 ESSASL--EGSLSKFALPGKSEVTSSFNASNT-NIFQNYAMEVLISSCSRCRTCDCLVHD 1505
            ESSASL  E  LS+ +L   S   SS   S+T   FQ+ ++E+L+SSCS CR CD LV+D
Sbjct: 1110 ESSASLGSEWDLSESSLSNLSLRRSSERLSDTPGSFQSPSLEILLSSCSLCRACDSLVYD 1169

Query: 1506 EEIMAGWTADDSNLNTTCPFCGNIFLPFLNIEIRDLR 1542
            EEIMAGW  DDSNLNTTCPFC   F+P L+++  D R
Sbjct: 1170 EEIMAGWAPDDSNLNTTCPFCACPFVPLLSVQTLDSR 1206


>gi|29788755 SET binding factor 2 [Homo sapiens]
          Length = 1849

 Score =  137 bits (345), Expect = 1e-31
 Identities = 122/475 (25%), Positives = 208/475 (43%), Gaps = 47/475 (9%)

Query: 212 LICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGA 271
           +I R+PQ+D++    P+ + LFC P G     W  + +   P F   VLT   +++ Y +
Sbjct: 27  IIQRFPQKDWDDTPFPQGIELFCQPGG-----WQLSRERKQPTFFVVVLTDIDSDRHYCS 81

Query: 272 AIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTF 331
            + FYE       T+K+ +  G     G    ++ +   K + L+S   + + FR  L  
Sbjct: 82  CLTFYEAEINLQGTKKEEIE-GEAKVSGLIQPAE-VFAPKSLVLVSRLYYPEIFRACLGL 139

Query: 332 LYRYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGG 391
           +Y   +   +V  +E  I++    +  P+    + L  L   D  ++  P+   LP++G 
Sbjct: 140 IYTVYVDSLNV-SLESLIANLCACL-VPAAGGSQKLFSLGAGDRQLIQTPLHDSLPITGT 197

Query: 392 KFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPL 451
             + L Q LG +N ++L    +TE+K+L HS     L+    AL S++FP  +  PY+P+
Sbjct: 198 SVALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALESLMFPLKYSYPYIPI 257

Query: 452 CPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDVDTNTISQIGDKKNVAWKILPKK 511
            P  L +VLS+P PFI+G+ S +        DV   D+D  TI           KI    
Sbjct: 258 LPAQLLEVLSSPTPFIIGVHSVFKTDVHELLDVIIADLDGGTI-----------KIPECI 306

Query: 512 PCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDF----NSGKRLHMIDLEIQEAFL 567
              +L   L +  Q    L   P      DL + D+ F     +     M+D E++  FL
Sbjct: 307 HLSSLPEPLLHQTQSALSLILHP------DLEVADHAFPPPRTALSHSKMLDKEVRAVFL 360

Query: 568 FFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQMFIR 627
              A + +GYRS L+ I         +    F   AFL  R      F   +     F  
Sbjct: 361 RLFAQLFQGYRSCLQLI-----RIHAEPVIHFHKTAFLGQRGLVENDFLTKVLSGMAFAG 415

Query: 628 FIEECSFVSDKDASLAFFDDC----VDKVDMDKSGEVRLIE-----LDESFKSEH 673
           F+ E         S   FD+     V+++ ++++  V++I+      ++ FK+E+
Sbjct: 416 FVSE---RGPPYRSCDLFDELVAFEVERIKVEENNPVKMIKHVRELAEQLFKNEN 467


>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
          Length = 1274

 Score =  133 bits (335), Expect = 1e-30
 Identities = 128/550 (23%), Positives = 226/550 (41%), Gaps = 111/550 (20%)

Query: 207 SYKAGLICRYPQE-DYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASA 265
           ++K+ ++  YPQ  ++  F   ++V + C+P G +      N     P F +F++T    
Sbjct: 54  TFKSKVLAHYPQNIEWNPFD-QDAVNMLCMPKGLSFRTQTDNKD---PQFHSFIITREDG 109

Query: 266 EKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGKSD----------------------- 302
            + YG  + FYE  + + +    + L  + +A+  S                        
Sbjct: 110 SRTYGFVLTFYEEVTSKQICTAMQTLYQMHNAEHYSSVYASSSCSMDSLASSLDEGDTTS 169

Query: 303 ------------SSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISG-PHVLPIEKHI 349
                       S  T++ +K ICL++  PF  A +KFL  LY+   S  P  LP+E +I
Sbjct: 170 LLKLQRYNSYDISRDTLYVSKSICLITPLPFMQACKKFLIQLYKAVTSQQPPPLPLESYI 229

Query: 350 SHFMHKVPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLL 409
            + +++VP P P R   L     ++ +I  +P  S LPLS        + LG EN V + 
Sbjct: 230 HNILYEVPLPPPGRS--LKFYGVYEPVICQRPGPSELPLSDYPLREAFELLGLENLVQVF 287

Query: 410 VFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVG 469
              + E +IL++S     L +V E + +++FPF W   YVP+ P +L   L AP P+++G
Sbjct: 288 TCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMG 347

Query: 470 ------------------------IDSRYFDLYDP----PPDVSCVDVDTNTISQIG--- 498
                                   ID+ + +L +     P  V  +   +  + Q G   
Sbjct: 348 LQSKEGTDRSKLELPQEANLCFVDIDNHFIELPEEFPQFPNKVDFIQELSEVLVQFGIPP 407

Query: 499 -----------DKKNVAWKILPKKPCKNLMNTLNNL--------HQQLAKLQQRPRDDGL 539
                        KN+  K L     KN     NN+        ++ +A+LQ   +  G+
Sbjct: 408 EGSLHCSESTSKLKNMVLKDLVNDK-KNGNVCTNNISMYELLKGNETIARLQALAKRTGV 466

Query: 540 ----MDLAINDYDFNSGKRLH---------MIDLEIQEAFLFFMASILKGYRSYLRPITQ 586
               MDL+ +  + +   +LH          ++++++E F      +   Y +++    Q
Sbjct: 467 AVEKMDLSASLGEKDKDLKLHCEEAELRDYQLNVQLREVFANRFTQMFADYEAFVIQTAQ 526

Query: 587 APSETATDAASL--FALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEE--CSFVSDKDASL 642
                 T+   +  F   +FL  +   +  F +   +TQMF  FI+    S   +KD  L
Sbjct: 527 DMESWLTNREQMQNFDKASFLSDQPEPYLPFLSRFIETQMFATFIDNKIMSQWEEKDPLL 586

Query: 643 AFFDDCVDKV 652
             FD  +DK+
Sbjct: 587 RVFDTRIDKI 596


>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
          Length = 1287

 Score =  127 bits (319), Expect = 1e-28
 Identities = 151/664 (22%), Positives = 263/664 (39%), Gaps = 150/664 (22%)

Query: 207 SYKAGLICRYPQE-DYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASA 265
           ++K+ ++ RYP+  ++  F   ++V + C+P G   +      +   P F  F++T    
Sbjct: 72  TFKSKVLARYPENVEWNPFD-QDAVGMLCMPKGLAFKTQADPRE---PQFHAFIITREDG 127

Query: 266 EKVYGAAIQFYEPYSEENLTEKQRLL----------LGLTSADGKSDSSK---------- 305
            + +G A+ FYE  + + +    + L          L    AD +  SS           
Sbjct: 128 SRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPPADDRDQSSMEDGEDTPVTK 187

Query: 306 ------------TIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISG-PHVLPIEKHISHF 352
                       T++ +KCICL++   F  A R  L  L++   S  P  LP+E +I + 
Sbjct: 188 LQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLESYIYNV 247

Query: 353 MHKVPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFA 412
           +++VP P P R   L     +  +I  +P ++ LPL       + + LG EN   L   A
Sbjct: 248 LYEVPLPPPGRS--LKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCA 305

Query: 413 VTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDS 472
           + E +IL++S     L +V E + +++FPF W   YVP+ P +L   L AP P+++G+ S
Sbjct: 306 LLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHS 365

Query: 473 RYFD----LYDPPPDVSC-VDVDTNTISQIGDKKN---------------VAWKILPK-- 510
              D    L  P     C VD+D + I    D                  +A+ I P+  
Sbjct: 366 NGLDDRSKLELPQEANLCFVDIDNHFIELPEDLPQFPNKLEFVQEVSEILMAFGIPPEGN 425

Query: 511 KPCKNLMNTLNNL---------------------------HQQLAKLQQRPRDDG--LMD 541
             C    + L  L                           ++ +A+LQ   +  G  L  
Sbjct: 426 LHCSESASKLKRLRASELVSDKRNGNIAGSPLHSYELLKENETIARLQALVKRTGVSLEK 485

Query: 542 LAINDYDFNSGKRL-----------HMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSE 590
           L + + D +S K L           + ++++I+E F      +   Y  ++   +Q    
Sbjct: 486 LEVRE-DPSSNKDLKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVFVIQPSQDKES 544

Query: 591 TATDAASL--FALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEE---CSFVSDKDASLAFF 645
             T+   +  F   +FL  +   +  F +   +TQMF  FI+    C    DKD  L  F
Sbjct: 545 WFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDDDDKDPVLRVF 604

Query: 646 DDCVDKV----------------------DMDKSGEVRLIELDESFKSEHTVFVTPPEIP 683
           D  VDK+                      + +K+ E+RL ++D      HT        P
Sbjct: 605 DSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAEKAIELRLAKID------HTAI-----HP 653

Query: 684 HLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQAKKNKLPSKSSSPNSPLPMFRRTKQEI 743
           HL + +    +Y    FP L++++                +K +  N+P    R+ +Q+ 
Sbjct: 654 HLLDMKIGQGKYEPGFFPKLQSDVL---------STGPASNKWTKRNAPAQWRRKDRQKQ 704

Query: 744 KSAH 747
            + H
Sbjct: 705 HTEH 708


>gi|239735519 SET binding factor 1 [Homo sapiens]
          Length = 1893

 Score =  125 bits (313), Expect = 5e-28
 Identities = 109/437 (24%), Positives = 180/437 (41%), Gaps = 49/437 (11%)

Query: 212 LICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGA 271
           ++ R+P++D+E    P+ + LFC P G     W    +   P F   VLT  ++E+ Y A
Sbjct: 27  ILQRFPEKDWEDNPFPQGIELFCQPSG-----WQLCPERNPPTFFVAVLTDINSERHYCA 81

Query: 272 AIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTN-------------KCICLLSH 318
            + F+EP      T +       T  + + D     H +             K + L+S 
Sbjct: 82  CLTFWEPAEPSQETTRVE---DATEREEEGDEGGQTHLSPTAPAPSAQLFAPKTLVLVSR 138

Query: 319 WPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPHDNLIL 378
               + FR  L  +Y   + G +V  +E  I + +     P     +  + L   D  ++
Sbjct: 139 LDHTEVFRNSLGLIYAIHVEGLNVC-LENVIGNLL-TCTVPLAGGSQRTISLGAGDRQVI 196

Query: 379 SQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSM 438
             P++  LP+S    + L + LG  N ++L   A+TEHK+L  S     L      L+++
Sbjct: 197 QTPLADSLPVSRCSVALLFRQLGITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLAL 256

Query: 439 IFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDVDTNTISQIG 498
           +FP  +   YVP+ P  L +VLS P PFI+G+++ +        DV   D+D  T++   
Sbjct: 257 LFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQAETQELLDVIVADLDGGTVT--- 313

Query: 499 DKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDF----NSGKR 554
                    +P+  C ++      L  Q   +     D    +L + D  F     S   
Sbjct: 314 ---------IPE--CVHIPPLPEPLQSQTHSVLSMVLDP---ELELADLAFPPPTTSTSS 359

Query: 555 LHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQK 614
           L M D E++  FL   A +L+GYR  L  +   P     +    F   AFL  R      
Sbjct: 360 LKMQDKELRAVFLRLFAQLLQGYRWCLHVVRIHP-----EPVIRFHKAAFLGQRGLVEDD 414

Query: 615 FYNMMTKTQMFIRFIEE 631
           F   + +   F  F+ E
Sbjct: 415 FLMKVLEGMAFAGFVSE 431


>gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]
          Length = 471

 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 103/427 (24%), Positives = 175/427 (40%), Gaps = 82/427 (19%)

Query: 213 ICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAA 272
           + R  QE+ E   L +++PLFC P G     W S ++YP   FS FVLT     +  G  
Sbjct: 85  LLRGQQEEEER--LLKAIPLFCFPDGNE---WASLTEYPRETFS-FVLTNVDGSRKIGYC 138

Query: 273 IQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFL 332
                          +RLL           +       K  C++S    F  F K L  +
Sbjct: 139 ---------------RRLL----------PAGPGPRLPKVYCIISCIGCFGLFSKILDEV 173

Query: 333 Y-RYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPHDN---LILSQPVSSPLPL 388
             R+ IS   + P  + +     +  FP+P +   L    P      + L++P+ S L  
Sbjct: 174 EKRHQISMAVIYPFMQGL----REAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHL-- 227

Query: 389 SGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPY 448
               FS+LL  L  E  + +   AV E KI+  +   S L+    A  ++++PF W   Y
Sbjct: 228 EHVDFSSLLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTY 287

Query: 449 VPLCPLALADVLSAPCPFIVGIDSRYFD--LYDPPPDVSCVDVDTNT-ISQIGDKKNVAW 505
           +P+ P +L   +  P PF+VG+  R+    +  P  +V  V++   T +  +GD+K+   
Sbjct: 288 IPVVPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKD--- 344

Query: 506 KILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEA 565
            ILP K   +++++L                             N  K    I+  +   
Sbjct: 345 -ILPPKLQDDILDSLGQ-------------------------GINELKTAEQINEHVSGP 378

Query: 566 FLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRS-RDRSHQKFYNMMTKTQM 624
           F+ F   I+  Y SY++           +    F  ++F ++   +++++F     KTQ+
Sbjct: 379 FVQFFVKIVGHYASYIK--------REANGQGHFQERSFCKALTSKTNRRFVKKFVKTQL 430

Query: 625 FIRFIEE 631
           F  FI+E
Sbjct: 431 FSLFIQE 437


>gi|209863002 MAP-kinase activating death domain-containing protein
           isoform j [Homo sapiens]
          Length = 1541

 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)

Query: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262
           +++V+    L+ RYP ED+  F LP  V  FC P G          +  L   ++FV T 
Sbjct: 25  SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81

Query: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293
              +     YG  + FY  +                          SEE  TE       
Sbjct: 82  TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141

Query: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335
           L   SAD               K+ S     T   +C+LSH+PFF  FR+ L  L R   
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201

Query: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360
                + G  +                  L +E+  S  +H +             P P 
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261

Query: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417
             + R+ +++ P +    L  + P  S   L        L+ LG +  + +L   + EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321

Query: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474
           +++ S   + L+    A V+MI+P  +  P +PL P  +A    +L AP P+I+G+ + +
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381

Query: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521
           F     +  P DV  VD+D+N +  I         ILP       KK  K  + +++   
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439

Query: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570
               NL      Q++  L  RP +D     +        G  +  +D+  + A + F   
Sbjct: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499

Query: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623
           A++L+G++ + R +   P          F   +FL SR R    F   + +TQ
Sbjct: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546


>gi|209862998 MAP-kinase activating death domain-containing protein
           isoform i [Homo sapiens]
          Length = 1544

 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)

Query: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262
           +++V+    L+ RYP ED+  F LP  V  FC P G          +  L   ++FV T 
Sbjct: 25  SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81

Query: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293
              +     YG  + FY  +                          SEE  TE       
Sbjct: 82  TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141

Query: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335
           L   SAD               K+ S     T   +C+LSH+PFF  FR+ L  L R   
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201

Query: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360
                + G  +                  L +E+  S  +H +             P P 
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261

Query: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417
             + R+ +++ P +    L  + P  S   L        L+ LG +  + +L   + EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321

Query: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474
           +++ S   + L+    A V+MI+P  +  P +PL P  +A    +L AP P+I+G+ + +
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381

Query: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521
           F     +  P DV  VD+D+N +  I         ILP       KK  K  + +++   
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439

Query: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570
               NL      Q++  L  RP +D     +        G  +  +D+  + A + F   
Sbjct: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499

Query: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623
           A++L+G++ + R +   P          F   +FL SR R    F   + +TQ
Sbjct: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546


>gi|209862994 MAP-kinase activating death domain-containing protein
           isoform d [Homo sapiens]
          Length = 1647

 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)

Query: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262
           +++V+    L+ RYP ED+  F LP  V  FC P G          +  L   ++FV T 
Sbjct: 25  SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81

Query: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293
              +     YG  + FY  +                          SEE  TE       
Sbjct: 82  TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141

Query: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335
           L   SAD               K+ S     T   +C+LSH+PFF  FR+ L  L R   
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201

Query: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360
                + G  +                  L +E+  S  +H +             P P 
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261

Query: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417
             + R+ +++ P +    L  + P  S   L        L+ LG +  + +L   + EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321

Query: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474
           +++ S   + L+    A V+MI+P  +  P +PL P  +A    +L AP P+I+G+ + +
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381

Query: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521
           F     +  P DV  VD+D+N +  I         ILP       KK  K  + +++   
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439

Query: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570
               NL      Q++  L  RP +D     +        G  +  +D+  + A + F   
Sbjct: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499

Query: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623
           A++L+G++ + R +   P          F   +FL SR R    F   + +TQ
Sbjct: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546


>gi|18860873 MAP-kinase activating death domain-containing protein
           isoform g [Homo sapiens]
          Length = 1581

 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)

Query: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262
           +++V+    L+ RYP ED+  F LP  V  FC P G          +  L   ++FV T 
Sbjct: 25  SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81

Query: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293
              +     YG  + FY  +                          SEE  TE       
Sbjct: 82  TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141

Query: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335
           L   SAD               K+ S     T   +C+LSH+PFF  FR+ L  L R   
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201

Query: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360
                + G  +                  L +E+  S  +H +             P P 
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261

Query: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417
             + R+ +++ P +    L  + P  S   L        L+ LG +  + +L   + EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321

Query: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474
           +++ S   + L+    A V+MI+P  +  P +PL P  +A    +L AP P+I+G+ + +
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381

Query: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521
           F     +  P DV  VD+D+N +  I         ILP       KK  K  + +++   
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439

Query: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570
               NL      Q++  L  RP +D     +        G  +  +D+  + A + F   
Sbjct: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499

Query: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623
           A++L+G++ + R +   P          F   +FL SR R    F   + +TQ
Sbjct: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546


>gi|209862987 MAP-kinase activating death domain-containing protein
           isoform f [Homo sapiens]
          Length = 1479

 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)

Query: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262
           +++V+    L+ RYP ED+  F LP  V  FC P G          +  L   ++FV T 
Sbjct: 25  SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81

Query: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293
              +     YG  + FY  +                          SEE  TE       
Sbjct: 82  TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141

Query: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335
           L   SAD               K+ S     T   +C+LSH+PFF  FR+ L  L R   
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201

Query: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360
                + G  +                  L +E+  S  +H +             P P 
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261

Query: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417
             + R+ +++ P +    L  + P  S   L        L+ LG +  + +L   + EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321

Query: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474
           +++ S   + L+    A V+MI+P  +  P +PL P  +A    +L AP P+I+G+ + +
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381

Query: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521
           F     +  P DV  VD+D+N +  I         ILP       KK  K  + +++   
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439

Query: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570
               NL      Q++  L  RP +D     +        G  +  +D+  + A + F   
Sbjct: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499

Query: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623
           A++L+G++ + R +   P          F   +FL SR R    F   + +TQ
Sbjct: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546


>gi|209862983 MAP-kinase activating death domain-containing protein
           isoform e [Homo sapiens]
          Length = 1608

 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)

Query: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262
           +++V+    L+ RYP ED+  F LP  V  FC P G          +  L   ++FV T 
Sbjct: 25  SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81

Query: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293
              +     YG  + FY  +                          SEE  TE       
Sbjct: 82  TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141

Query: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335
           L   SAD               K+ S     T   +C+LSH+PFF  FR+ L  L R   
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201

Query: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360
                + G  +                  L +E+  S  +H +             P P 
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261

Query: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417
             + R+ +++ P +    L  + P  S   L        L+ LG +  + +L   + EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321

Query: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474
           +++ S   + L+    A V+MI+P  +  P +PL P  +A    +L AP P+I+G+ + +
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381

Query: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521
           F     +  P DV  VD+D+N +  I         ILP       KK  K  + +++   
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439

Query: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570
               NL      Q++  L  RP +D     +        G  +  +D+  + A + F   
Sbjct: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499

Query: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623
           A++L+G++ + R +   P          F   +FL SR R    F   + +TQ
Sbjct: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546


>gi|209862979 MAP-kinase activating death domain-containing protein
           isoform c [Homo sapiens]
          Length = 1545

 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)

Query: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262
           +++V+    L+ RYP ED+  F LP  V  FC P G          +  L   ++FV T 
Sbjct: 25  SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81

Query: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293
              +     YG  + FY  +                          SEE  TE       
Sbjct: 82  TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141

Query: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335
           L   SAD               K+ S     T   +C+LSH+PFF  FR+ L  L R   
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201

Query: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360
                + G  +                  L +E+  S  +H +             P P 
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261

Query: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417
             + R+ +++ P +    L  + P  S   L        L+ LG +  + +L   + EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321

Query: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474
           +++ S   + L+    A V+MI+P  +  P +PL P  +A    +L AP P+I+G+ + +
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381

Query: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521
           F     +  P DV  VD+D+N +  I         ILP       KK  K  + +++   
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439

Query: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570
               NL      Q++  L  RP +D     +        G  +  +D+  + A + F   
Sbjct: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499

Query: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623
           A++L+G++ + R +   P          F   +FL SR R    F   + +TQ
Sbjct: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546


>gi|209862975 MAP-kinase activating death domain-containing protein
           isoform b [Homo sapiens]
          Length = 1565

 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)

Query: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262
           +++V+    L+ RYP ED+  F LP  V  FC P G          +  L   ++FV T 
Sbjct: 25  SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81

Query: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293
              +     YG  + FY  +                          SEE  TE       
Sbjct: 82  TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141

Query: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335
           L   SAD               K+ S     T   +C+LSH+PFF  FR+ L  L R   
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201

Query: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360
                + G  +                  L +E+  S  +H +             P P 
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261

Query: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417
             + R+ +++ P +    L  + P  S   L        L+ LG +  + +L   + EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321

Query: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474
           +++ S   + L+    A V+MI+P  +  P +PL P  +A    +L AP P+I+G+ + +
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381

Query: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521
           F     +  P DV  VD+D+N +  I         ILP       KK  K  + +++   
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439

Query: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570
               NL      Q++  L  RP +D     +        G  +  +D+  + A + F   
Sbjct: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499

Query: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623
           A++L+G++ + R +   P          F   +FL SR R    F   + +TQ
Sbjct: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546


>gi|209862971 MAP-kinase activating death domain-containing protein
           isoform a [Homo sapiens]
          Length = 1588

 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)

Query: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262
           +++V+    L+ RYP ED+  F LP  V  FC P G          +  L   ++FV T 
Sbjct: 25  SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81

Query: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293
              +     YG  + FY  +                          SEE  TE       
Sbjct: 82  TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141

Query: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335
           L   SAD               K+ S     T   +C+LSH+PFF  FR+ L  L R   
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201

Query: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360
                + G  +                  L +E+  S  +H +             P P 
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261

Query: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417
             + R+ +++ P +    L  + P  S   L        L+ LG +  + +L   + EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321

Query: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474
           +++ S   + L+    A V+MI+P  +  P +PL P  +A    +L AP P+I+G+ + +
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381

Query: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521
           F     +  P DV  VD+D+N +  I         ILP       KK  K  + +++   
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439

Query: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570
               NL      Q++  L  RP +D     +        G  +  +D+  + A + F   
Sbjct: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499

Query: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623
           A++L+G++ + R +   P          F   +FL SR R    F   + +TQ
Sbjct: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546


>gi|209571517 MAP-kinase activating death domain-containing protein
           isoform h [Homo sapiens]
          Length = 1587

 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)

Query: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262
           +++V+    L+ RYP ED+  F LP  V  FC P G          +  L   ++FV T 
Sbjct: 25  SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81

Query: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293
              +     YG  + FY  +                          SEE  TE       
Sbjct: 82  TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141

Query: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335
           L   SAD               K+ S     T   +C+LSH+PFF  FR+ L  L R   
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201

Query: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360
                + G  +                  L +E+  S  +H +             P P 
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261

Query: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417
             + R+ +++ P +    L  + P  S   L        L+ LG +  + +L   + EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321

Query: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474
           +++ S   + L+    A V+MI+P  +  P +PL P  +A    +L AP P+I+G+ + +
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381

Query: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521
           F     +  P DV  VD+D+N +  I         ILP       KK  K  + +++   
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439

Query: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570
               NL      Q++  L  RP +D     +        G  +  +D+  + A + F   
Sbjct: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499

Query: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623
           A++L+G++ + R +   P          F   +FL SR R    F   + +TQ
Sbjct: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546


>gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]
          Length = 1009

 Score = 85.5 bits (210), Expect = 5e-16
 Identities = 101/412 (24%), Positives = 181/412 (43%), Gaps = 67/412 (16%)

Query: 228 ESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEK 287
           +++P FC P     + W    ++    FS FVLTG    + +G                 
Sbjct: 609 KAIPQFCFP---DAKDWVPVQQFTSETFS-FVLTGEDGSRRFGYC--------------- 649

Query: 288 QRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLY-RYSISGPHVLPIE 346
           +RLL G     GK      ++     C++S    F  F + L  +  R  IS   V P+ 
Sbjct: 650 RRLLPG-----GKGKRLPEVY-----CIVSRLGCFSLFSRILDEVEKRRGISPALVQPLM 699

Query: 347 KHISHFMHKVPFPSPQRPRILVQLSPHDN---LILSQPVSSPLPLSGGKFSTLLQNLGPE 403
           + +     + PFP+  +  ++    P      + L +P+ S L      F +L  +L   
Sbjct: 700 RSVM----EAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRL--EHVDFESLFSSLSVR 753

Query: 404 NAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAP 463
           + V +    + E +++  + + S+L+    A+V++I+PF W   Y+P+ P A+ D++ +P
Sbjct: 754 HLVCVFASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSP 813

Query: 464 CPFIVGIDSRYFDLYD--PPPDVSCVD-VDTNTISQIGDKKNVAWKILPKKPCKNLMNTL 520
            PF++G+ S    L    P  +V  VD V++  + Q+ D+ +    ILP+K    L   L
Sbjct: 814 TPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQMDDEDS----ILPRK----LQVAL 865

Query: 521 NNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSY 580
            ++ +Q  +L    +D+G +       D   G     ++  + EAF+ F   I+  Y  +
Sbjct: 866 EHILEQRNELACE-QDEGPL-------DGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLF 917

Query: 581 LRPITQAPSETATDAASLFALQAFLRS-RDRSHQKFYNMMTKTQMFIRFIEE 631
           L   T    E  T        +AF ++   +S + F  +  +TQMF  FI+E
Sbjct: 918 L---TSGEREERT-----LQREAFRKAVSSKSLRHFLEVFMETQMFRGFIQE 961


>gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo
           sapiens]
          Length = 755

 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 100/425 (23%), Positives = 158/425 (37%), Gaps = 95/425 (22%)

Query: 212 LICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGA 271
           ++ ++P ED+    + +SVP FC P           S+  +    TFVLT   +++ +G 
Sbjct: 31  VLWKFP-EDFGDQEILQSVPKFCFPFDVE-----RVSQNQVGQHFTFVLTDIESKQRFGF 84

Query: 272 AIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTF 331
                            RL  G T                C+C+LS+ P+F+ + K L  
Sbjct: 85  C----------------RLTSGGTI---------------CLCILSYLPWFEVYYKLLNT 113

Query: 332 LYRYSISGPHVLPIEKHISHFMHKV---PFPSPQRPRILVQLSPHDNLILSQPVSSPLPL 388
           L  Y         +E  ++  +  +   P P    P   V LS H   I       P   
Sbjct: 114 LADYLAK-----ELENDLNETLRSLYNHPVPKANTP---VNLSVHSYFIAPDVTGLPTIP 165

Query: 389 SGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPY 448
                +     +   N + L    + E +I+I S + S LT+      ++++P +W   Y
Sbjct: 166 ESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIY 225

Query: 449 VPLCPLALADVLSAPCPFIVGIDSRYFDLYDPP--PDVSCVDVDTNTI-SQIGDKKNVAW 505
           +P+ P  L D   AP P+++GI S   +        DV  ++VDTNT+ S   D  N   
Sbjct: 226 IPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNN--- 282

Query: 506 KILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEA 565
             LP      L N L        K Q     DG                       +  A
Sbjct: 283 --LPSDVVSALKNKL--------KKQSTATGDG-----------------------VARA 309

Query: 566 FLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQMF 625
           FL   A++   YR  LR     P E  T     F  ++F++ R    ++F       Q+F
Sbjct: 310 FLRAQAALFGSYRDALR---YKPGEPIT-----FCEESFVKHRSSVMKQFLETAINLQLF 361

Query: 626 IRFIE 630
            +FI+
Sbjct: 362 KQFID 366


>gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
          Length = 1137

 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 100/434 (23%), Positives = 180/434 (41%), Gaps = 71/434 (16%)

Query: 206  VSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASA 265
            VSY+   + R  ++  E+    +++P FC P     + W   S+Y    FS F+LTG   
Sbjct: 718  VSYQFPKLDRPTKQMREAEERLKAIPQFCFP---DAKDWLPVSEYSSETFS-FMLTGEDG 773

Query: 266  EKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAF 325
             + +G                 +RLL           S K     +  C++S    F  F
Sbjct: 774  SRRFGYC---------------RRLL----------PSGKGPRLPEVYCVISRLGCFGLF 808

Query: 326  RKFLTFLYRY-SISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSP---HDNLILSQP 381
             K L  + R   IS   V P  + +     + PFP+P +   +    P   ++ L L +P
Sbjct: 809  SKVLDEVERRRGISAALVYPFMRSLM----ESPFPAPGKTIKVKTFLPGAGNEVLELRRP 864

Query: 382  VSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFP 441
            + S L      F  L   L     + +    + E +++  + + S L+S + A+V++++P
Sbjct: 865  MDSRL--EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYP 922

Query: 442  FHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDVDTNT---ISQIG 498
            F W   ++P+ P ++ D++  P PF+VG+ S         P    + V+  +   I Q+ 
Sbjct: 923  FSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMD 982

Query: 499  DKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMI 558
            D+      +LP+K           L   L +  +R       +L   D D +S    + +
Sbjct: 983  DEDT----LLPRK-----------LQAALEQALERKN-----ELISQDSDSDSDDECNTL 1022

Query: 559  DLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRS-RDRSHQKFYN 617
            +  + E F+ F    +  Y  +L       SE    A   F  +AF +S   +S ++F  
Sbjct: 1023 NGLVSEVFIRFFVETVGHYSLFL-----TQSEKGERA---FQREAFRKSVASKSIRRFLE 1074

Query: 618  MMTKTQMFIRFIEE 631
            +  ++QMF  FI++
Sbjct: 1075 VFMESQMFAGFIQD 1088


>gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
          Length = 1137

 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 100/434 (23%), Positives = 180/434 (41%), Gaps = 71/434 (16%)

Query: 206  VSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASA 265
            VSY+   + R  ++  E+    +++P FC P     + W   S+Y    FS F+LTG   
Sbjct: 718  VSYQFPKLDRPTKQMREAEERLKAIPQFCFP---DAKDWLPVSEYSSETFS-FMLTGEDG 773

Query: 266  EKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAF 325
             + +G                 +RLL           S K     +  C++S    F  F
Sbjct: 774  SRRFGYC---------------RRLL----------PSGKGPRLPEVYCVISRLGCFGLF 808

Query: 326  RKFLTFLYRY-SISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSP---HDNLILSQP 381
             K L  + R   IS   V P  + +     + PFP+P +   +    P   ++ L L +P
Sbjct: 809  SKVLDEVERRRGISAALVYPFMRSLM----ESPFPAPGKTIKVKTFLPGAGNEVLELRRP 864

Query: 382  VSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFP 441
            + S L      F  L   L     + +    + E +++  + + S L+S + A+V++++P
Sbjct: 865  MDSRL--EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYP 922

Query: 442  FHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDVDTNT---ISQIG 498
            F W   ++P+ P ++ D++  P PF+VG+ S         P    + V+  +   I Q+ 
Sbjct: 923  FSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMD 982

Query: 499  DKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMI 558
            D+      +LP+K           L   L +  +R       +L   D D +S    + +
Sbjct: 983  DEDT----LLPRK-----------LQAALEQALERKN-----ELISQDSDSDSDDECNTL 1022

Query: 559  DLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRS-RDRSHQKFYN 617
            +  + E F+ F    +  Y  +L       SE    A   F  +AF +S   +S ++F  
Sbjct: 1023 NGLVSEVFIRFFVETVGHYSLFL-----TQSEKGERA---FQREAFRKSVASKSIRRFLE 1074

Query: 618  MMTKTQMFIRFIEE 631
            +  ++QMF  FI++
Sbjct: 1075 VFMESQMFAGFIQD 1088


>gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo
           sapiens]
          Length = 717

 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 100/434 (23%), Positives = 180/434 (41%), Gaps = 71/434 (16%)

Query: 206 VSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASA 265
           VSY+   + R  ++  E+    +++P FC P     + W   S+Y    FS F+LTG   
Sbjct: 298 VSYQFPKLDRPTKQMREAEERLKAIPQFCFP---DAKDWLPVSEYSSETFS-FMLTGEDG 353

Query: 266 EKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAF 325
            + +G                 +RLL           S K     +  C++S    F  F
Sbjct: 354 SRRFGYC---------------RRLL----------PSGKGPRLPEVYCVISRLGCFGLF 388

Query: 326 RKFLTFLYRY-SISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSP---HDNLILSQP 381
            K L  + R   IS   V P  + +     + PFP+P +   +    P   ++ L L +P
Sbjct: 389 SKVLDEVERRRGISAALVYPFMRSLM----ESPFPAPGKTIKVKTFLPGAGNEVLELRRP 444

Query: 382 VSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFP 441
           + S L      F  L   L     + +    + E +++  + + S L+S + A+V++++P
Sbjct: 445 MDSRL--EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYP 502

Query: 442 FHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDVDTNT---ISQIG 498
           F W   ++P+ P ++ D++  P PF+VG+ S         P    + V+  +   I Q+ 
Sbjct: 503 FSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMD 562

Query: 499 DKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMI 558
           D+      +LP+K           L   L +  +R       +L   D D +S    + +
Sbjct: 563 DEDT----LLPRK-----------LQAALEQALERKN-----ELISQDSDSDSDDECNTL 602

Query: 559 DLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRS-RDRSHQKFYN 617
           +  + E F+ F    +  Y  +L       SE    A   F  +AF +S   +S ++F  
Sbjct: 603 NGLVSEVFIRFFVETVGHYSLFL-----TQSEKGERA---FQREAFRKSVASKSIRRFLE 654

Query: 618 MMTKTQMFIRFIEE 631
           +  ++QMF  FI++
Sbjct: 655 VFMESQMFAGFIQD 668


>gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]
          Length = 871

 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 103/445 (23%), Positives = 184/445 (41%), Gaps = 81/445 (18%)

Query: 202 KTNTVSYKAGLICRYPQEDYESFSLPES-------VPLFCLPMGATIECWPSNSKYPLPV 254
           K + +SY   +I ++P +D   +   +        +P FC P       W   S+     
Sbjct: 445 KPSGISYIPQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCFPDSKD---WMPTSELKSET 501

Query: 255 FSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCIC 314
           FS FVLTG    + +G                K+ L +G           K     +  C
Sbjct: 502 FS-FVLTGEDGSRWFGYC--------------KKLLPVG-----------KGKRLPEVYC 535

Query: 315 LLSHWPFFDAFRKFLTFLY-RYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSP- 372
           ++S    F+ F K L  +  R  +S   V P  + +     + PFP+P R   +    P 
Sbjct: 536 MVSRLGCFNLFSKILDEVEKRREMSPALVYPFMRSVM----EAPFPAPGRTITVKSYLPG 591

Query: 373 --HDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTS 430
              +++ L +P+ S L      F  L + L   + + +    + E +++  +   S L+ 
Sbjct: 592 AGDESIELCRPLDSRL--EHVDFKCLFKCLSVCHLIRVCASLLLERRVIFVANSLSTLSK 649

Query: 431 VTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYF-DLYD-PPPDVSCVD 488
              A+V+ ++PF W   Y+P+ P ++ D++ +P PF++GI S     L D P  +V  VD
Sbjct: 650 CGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSLPQLQDLPIEEVLIVD 709

Query: 489 VDTNT-ISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDY 547
           +  +  + ++ D+     +ILP K    LM  L   ++ L + Q   +D  L  L     
Sbjct: 710 LCADKFLQEVSDED----EILPPKLQAALMQILEERNEILTQEQNFSQDVTLNSL----- 760

Query: 548 DFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRS 607
                         + EAF+ F   ++ G+ S    +T+           +F  + F +S
Sbjct: 761 --------------VSEAFVRFFVELV-GHYSLNMTVTER-------GERVFQREPFRKS 798

Query: 608 R-DRSHQKFYNMMTKTQMFIRFIEE 631
              RS + F ++  +TQMF  FI++
Sbjct: 799 HTSRSVRHFLDLFMETQMFAGFIQD 823


>gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens]
          Length = 559

 Score = 78.2 bits (191), Expect = 7e-14
 Identities = 89/377 (23%), Positives = 146/377 (38%), Gaps = 59/377 (15%)

Query: 264 SAEKVYGAAIQFYEPYSEENLTEKQ---RLLLGLTSADGKSDSS---KTIHTNKCICLLS 317
           S ++V     +F  P+  ++LT  Q        LT  D K        +     C C+LS
Sbjct: 42  SDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILS 101

Query: 318 HWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPHDNLI 377
           + P+F+ F K L  L  Y+         E  +   +HK+P P P    + V LS H    
Sbjct: 102 YLPWFEVFYKLLNILADYTTKRQENQWNE--LLETLHKLPIPDPG---VSVHLSVHSYFT 156

Query: 378 LSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVS 437
           +      P        +     +   N + L    + E +ILI   + S LT+      +
Sbjct: 157 VPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAA 216

Query: 438 MIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYD--PPPDVSCVDVDTNTIS 495
           M++P +W   Y+P+ P  L D   AP P+++GI     +        DV  ++VDTNT+ 
Sbjct: 217 MLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLE 276

Query: 496 QIGDKKNVAWKILPKKPCKNLMN-TLNNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKR 554
                        P    ++L N  +++L  +L K+     D                  
Sbjct: 277 ------------TPFDDLQSLPNDVISSLKNRLKKVSTTTGDG----------------- 307

Query: 555 LHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFL-RSRDRSHQ 613
                  +  AFL   A+    YR+ L+     P E  T     F  +AF+   R  + +
Sbjct: 308 -------VARAFLKAQAAFFGSYRNALK---IEPEEPIT-----FCEEAFVSHYRSGAMR 352

Query: 614 KFYNMMTKTQMFIRFIE 630
           +F    T+ Q+F +FI+
Sbjct: 353 QFLQNATQLQLFKQFID 369


>gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens]
          Length = 1009

 Score = 78.2 bits (191), Expect = 7e-14
 Identities = 89/377 (23%), Positives = 146/377 (38%), Gaps = 59/377 (15%)

Query: 264 SAEKVYGAAIQFYEPYSEENLTEKQ---RLLLGLTSADGKSDSS---KTIHTNKCICLLS 317
           S ++V     +F  P+  ++LT  Q        LT  D K        +     C C+LS
Sbjct: 42  SDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILS 101

Query: 318 HWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPHDNLI 377
           + P+F+ F K L  L  Y+         E  +   +HK+P P P    + V LS H    
Sbjct: 102 YLPWFEVFYKLLNILADYTTKRQENQWNE--LLETLHKLPIPDPG---VSVHLSVHSYFT 156

Query: 378 LSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVS 437
           +      P        +     +   N + L    + E +ILI   + S LT+      +
Sbjct: 157 VPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAA 216

Query: 438 MIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYD--PPPDVSCVDVDTNTIS 495
           M++P +W   Y+P+ P  L D   AP P+++GI     +        DV  ++VDTNT+ 
Sbjct: 217 MLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLE 276

Query: 496 QIGDKKNVAWKILPKKPCKNLMN-TLNNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKR 554
                        P    ++L N  +++L  +L K+     D                  
Sbjct: 277 ------------TPFDDLQSLPNDVISSLKNRLKKVSTTTGDG----------------- 307

Query: 555 LHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFL-RSRDRSHQ 613
                  +  AFL   A+    YR+ L+     P E  T     F  +AF+   R  + +
Sbjct: 308 -------VARAFLKAQAAFFGSYRNALK---IEPEEPIT-----FCEEAFVSHYRSGAMR 352

Query: 614 KFYNMMTKTQMFIRFIE 630
           +F    T+ Q+F +FI+
Sbjct: 353 QFLQNATQLQLFKQFID 369


>gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]
          Length = 1198

 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 84/415 (20%), Positives = 160/415 (38%), Gaps = 53/415 (12%)

Query: 229 SVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQ 288
           ++P  C P G  +   P             VLT     + YG   Q+Y P  +E      
Sbjct: 41  TLPQLCFPGGVCVATEPKED-----CVHFLVLTDVCGNRTYGVVAQYYRPLHDE------ 89

Query: 289 RLLLGLTSADGKSDSS-KTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEK 347
                    +GK+            +C++S +P++++ +  L+ L    +       ++ 
Sbjct: 90  -----YCFYNGKTHRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLAL-LKPCKDFEVDS 143

Query: 348 HISHFMHK---VPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPEN 404
           HI  F  K   +P P P  P  LV       ++L        P+        L    PE 
Sbjct: 144 HIKDFAAKLSLIPSPPPG-PLHLVFNMKSLQIVLPARADPESPILDLDLHLPLLCFRPEK 202

Query: 405 AVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPC 464
            + +L   +TE +I+  S   ++LT VTE  ++ ++P  W  P+VP+    + D + AP 
Sbjct: 203 VLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPT 262

Query: 465 PFIVGIDSRYFDLYDPPPD-VSCVDVDTNTIS-QIGDKKNVAWKILPKKPCKNLMNTLNN 522
            F++G    +F+      D +  +++D  +I+       NV    +P    +  +  + +
Sbjct: 263 SFLMGCHLDHFEEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQS 322

Query: 523 --LHQQLAKLQQRPRDDGLMDLAINDYDFNSGKR-----LHMIDLEIQEAFLFFMASILK 575
             LH +L                ++  D   G+         ++ +IQ+  L  + SI +
Sbjct: 323 LQLHHELHAAH-----------LLSSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFR 371

Query: 576 GYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQMFIRFIE 630
             +++L                +F  + FL++R     +FY  +  T MF  F++
Sbjct: 372 DVKNHL-----------NYEHRVFNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLK 415


>gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo
           sapiens]
          Length = 426

 Score = 75.5 bits (184), Expect = 5e-13
 Identities = 101/437 (23%), Positives = 156/437 (35%), Gaps = 99/437 (22%)

Query: 212 LICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGA 271
           ++ ++P ED+    + +SVP FC P           S+  +    TFVLT   +++ +G 
Sbjct: 31  VLWKFP-EDFGDQEILQSVPKFCFPFDVE-----RVSQNQVGQHFTFVLTDIESKQRFGF 84

Query: 272 AIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTF 331
                            RL  G T                C+C+LS+ P+F+ + K L  
Sbjct: 85  C----------------RLTSGGTI---------------CLCILSYLPWFEVYYKLLNT 113

Query: 332 LYRYSISGPHVLPIEKHISHFMHKVP---------------FPSPQRPRILVQLSPHDNL 376
           L  Y          E   S + H VP                   Q  +    L PH   
Sbjct: 114 LADYLAKELENDLNETLRSLYNHPVPKANTPVNLSVNQEIFIACEQVLKDQPALVPHSYF 173

Query: 377 ILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALV 436
           I       P        +     +   N + L    + E +I+I S + S LT+      
Sbjct: 174 IAPDVTGLPTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSA 233

Query: 437 SMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDPP--PDVSCVDVDTNTI 494
           ++++P +W   Y+P+ P  L D   AP P+++GI S   +        DV  ++VDTNT+
Sbjct: 234 ALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTL 293

Query: 495 -SQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGK 553
            S   D  N     LP      L N L        K Q     DG               
Sbjct: 294 ESPFSDLNN-----LPSDVVSALKNKL--------KKQSTATGDG--------------- 325

Query: 554 RLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQ 613
                   +  AFL   A++   YR  LR     P E  T     F  ++F++ R    +
Sbjct: 326 --------VARAFLRAQAALFGSYRDALR---YKPGEPIT-----FCEESFVKHRSSVMK 369

Query: 614 KFYNMMTKTQMFIRFIE 630
           +F       Q+F +FI+
Sbjct: 370 QFLETAINLQLFKQFID 386


>gi|113205087 DENN/MADD domain containing 1C [Homo sapiens]
          Length = 801

 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 50/210 (23%), Positives = 89/210 (42%), Gaps = 29/210 (13%)

Query: 309 TNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILV 368
           T  C+C+LSH P+F+ F K L  +    ++   V   E+ + +   +    S   P+  V
Sbjct: 91  TQSCLCILSHLPWFEVFYKLLNTVGDL-LAQDQVTEAEELLQNLFQQ----SLSGPQASV 145

Query: 369 QLSPHDNLILSQPVSSPLPLSG-------------GKFSTLLQN---------LGPENAV 406
            L     + +S     P P  G             G+  ++ +N         +  EN V
Sbjct: 146 GLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTELVVAVTDENIV 205

Query: 407 TLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPF 466
            L    + E ++L+ + + S LTS   A  ++++P  W    +P  P  L D   AP P+
Sbjct: 206 GLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPHLLDYCCAPMPY 265

Query: 467 IVGIDSRYFDLYDPP--PDVSCVDVDTNTI 494
           ++G+ +   +        DV  ++VD NT+
Sbjct: 266 LIGVHASLAERVREKALEDVVVLNVDANTL 295


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.132    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,982,297
Number of Sequences: 37866
Number of extensions: 3643838
Number of successful extensions: 16916
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 47
Number of HSP's successfully gapped in prelim test: 119
Number of HSP's that attempted gapping in prelim test: 16127
Number of HSP's gapped (non-prelim): 723
length of query: 1906
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1789
effective length of database: 13,817,196
effective search space: 24718963644
effective search space used: 24718963644
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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