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Search of human proteins with 219842233
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]
(752 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens] 1498 0.0
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens] 1349 0.0
gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens] 1246 0.0
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] 1097 0.0
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 580 e-165
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 238 2e-62
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 238 2e-62
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 232 1e-60
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 232 1e-60
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 232 1e-60
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 232 1e-60
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 232 1e-60
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 226 5e-59
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 226 5e-59
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 226 5e-59
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 226 8e-59
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 225 1e-58
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens] 223 4e-58
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens] 223 4e-58
gi|29029632 anaplastic lymphoma kinase [Homo sapiens] 220 3e-57
gi|148596974 TXK tyrosine kinase [Homo sapiens] 220 3e-57
gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens] 220 4e-57
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 218 1e-56
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 217 3e-56
gi|221316650 ephrin receptor EphA1 [Homo sapiens] 215 1e-55
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 214 2e-55
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 213 4e-55
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 211 3e-54
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 211 3e-54
gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precurs... 211 3e-54
>gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]
Length = 752
Score = 1498 bits (3879), Expect = 0.0
Identities = 752/752 (100%), Positives = 752/752 (100%)
Query: 1 MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS 60
MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS
Sbjct: 1 MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS 60
Query: 61 RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW 120
RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW
Sbjct: 61 RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW 120
Query: 121 QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLF 180
QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLF
Sbjct: 121 QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLF 180
Query: 181 AHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDE 240
AHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDE
Sbjct: 181 AHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDE 240
Query: 241 VVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNE 300
VVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNE
Sbjct: 241 VVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNE 300
Query: 301 LTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVL 360
LTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVL
Sbjct: 301 LTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVL 360
Query: 361 QEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGR 420
QEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGR
Sbjct: 361 QEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGR 420
Query: 421 TPTLEILKSHISGIFRPKFSNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVP 480
TPTLEILKSHISGIFRPKFSNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVP
Sbjct: 421 TPTLEILKSHISGIFRPKFSNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVP 480
Query: 481 KDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARI 540
KDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARI
Sbjct: 481 KDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARI 540
Query: 541 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAG 600
LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAG
Sbjct: 541 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAG 600
Query: 601 MEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPE 660
MEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPE
Sbjct: 601 MEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPE 660
Query: 661 ALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVF 720
ALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVF
Sbjct: 661 ALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVF 720
Query: 721 RLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 752
RLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR
Sbjct: 721 RLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 752
>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
Length = 822
Score = 1349 bits (3491), Expect = 0.0
Identities = 706/822 (85%), Positives = 716/822 (87%), Gaps = 70/822 (8%)
Query: 1 MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS 60
MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS
Sbjct: 1 MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS 60
Query: 61 RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW 120
RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW
Sbjct: 61 RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW 120
Query: 121 QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLF 180
QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLF
Sbjct: 121 QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLF 180
Query: 181 AHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDE 240
AHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDE
Sbjct: 181 AHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDE 240
Query: 241 VVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNE 300
VVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNE
Sbjct: 241 VVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNE 300
Query: 301 LTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVL 360
LTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVL
Sbjct: 301 LTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVL 360
Query: 361 QEALQGLQVALCSQAK-------LQAQQE-----------LLQTKLEHLGPGE------- 395
QEALQGLQVALCSQAK LQ + E LLQ E
Sbjct: 361 QEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGR 420
Query: 396 ---------------------PPPVLLLQDDR-----------------------HSTSS 411
PPP+ L+ + + HS
Sbjct: 421 TPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDF 480
Query: 412 SEQEREGGRTPTLEILKSHISGIFR-PKFSNLYRLEGEGFPSIPLLIDHLLSTQQPLTKK 470
+E +G + L +L + F NLYRLEGEGFPSIPLLIDHLLSTQQPLTKK
Sbjct: 481 LVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKK 540
Query: 471 SGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDL 530
SGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDL
Sbjct: 541 SGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDL 600
Query: 531 KAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTL 590
KAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTL
Sbjct: 601 KAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTL 660
Query: 591 LQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLR 650
LQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLR
Sbjct: 661 LQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLR 720
Query: 651 QVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLP 710
QVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLP
Sbjct: 721 QVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLP 780
Query: 711 CPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 752
CPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR
Sbjct: 781 CPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 822
>gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]
Length = 694
Score = 1246 bits (3225), Expect = 0.0
Identities = 623/626 (99%), Positives = 626/626 (100%)
Query: 127 LTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRY 186
+++THSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRY
Sbjct: 69 ISQTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRY 128
Query: 187 VLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHR 246
VLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHR
Sbjct: 129 VLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHR 188
Query: 247 EMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESV 306
EMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESV
Sbjct: 189 EMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESV 248
Query: 307 QHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQG 366
QHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQG
Sbjct: 249 QHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQG 308
Query: 367 LQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEI 426
LQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEI
Sbjct: 309 LQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEI 368
Query: 427 LKSHISGIFRPKFSNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVL 486
LKSHISGIFRPKFSNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVL
Sbjct: 369 LKSHISGIFRPKFSNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVL 428
Query: 487 NHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSH 546
NHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSH
Sbjct: 429 NHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSH 488
Query: 547 PNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLES 606
PNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLES
Sbjct: 489 PNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLES 548
Query: 607 KCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGR 666
KCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGR
Sbjct: 549 KCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGR 608
Query: 667 YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQC 726
YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQC
Sbjct: 609 YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQC 668
Query: 727 WAYEPGQRPSFSTIYQELQSIRKRHR 752
WAYEPGQRPSFSTIYQELQSIRKRHR
Sbjct: 669 WAYEPGQRPSFSTIYQELQSIRKRHR 694
>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
Length = 764
Score = 1097 bits (2837), Expect = 0.0
Identities = 577/696 (82%), Positives = 590/696 (84%), Gaps = 70/696 (10%)
Query: 127 LTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRY 186
+++THSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRY
Sbjct: 69 ISQTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRY 128
Query: 187 VLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHR 246
VLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHR
Sbjct: 129 VLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHR 188
Query: 247 EMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESV 306
EMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESV
Sbjct: 189 EMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESV 248
Query: 307 QHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQG 366
QHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQG
Sbjct: 249 QHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQG 308
Query: 367 LQVALCSQAK-------LQAQQE-----------LLQTKLEHLGPGE------------- 395
LQVALCSQAK LQ + E LLQ E
Sbjct: 309 LQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEI 368
Query: 396 ---------------PPPVLLLQDDR-----------------------HSTSSSEQERE 417
PPP+ L+ + + HS +E +
Sbjct: 369 LKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQ 428
Query: 418 GGRTPTLEILKSHISGIFR-PKFSNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLH 476
G + L +L + F NLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLH
Sbjct: 429 GKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLH 488
Query: 477 RAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQ 536
RAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQ
Sbjct: 489 RAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQ 548
Query: 537 EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGD 596
EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGD
Sbjct: 549 EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGD 608
Query: 597 AAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKW 656
AAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKW
Sbjct: 609 AAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKW 668
Query: 657 TAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCP 716
TAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCP
Sbjct: 669 TAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCP 728
Query: 717 DAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 752
DAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR
Sbjct: 729 DAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 764
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 580 bits (1494), Expect = e-165
Identities = 348/829 (41%), Positives = 495/829 (59%), Gaps = 88/829 (10%)
Query: 1 MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS 60
MGF S+L H + ++Q+ ELRLLE ++K+MA R+KSD+EYA L ++ Q +
Sbjct: 1 MGFGSDL--KNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKEST 58
Query: 61 RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW 120
++ S +S+SW + QTE LSR+++ HAEDLNSGPL +L+++I+++QQ++K+Y
Sbjct: 59 VQMNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVH 118
Query: 121 QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEA-SKDKDRDKAKDKYVRSLWKL 179
QQ++ E+ K ++EKLK YR L ++ AK KY+EA +K K+ +KAK++Y ++ KL
Sbjct: 119 QQIEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKL 178
Query: 180 FAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEM---------------ACILK 224
HN+YVL ++ AQLH ++ + LP LL SLQ + EEM + + +
Sbjct: 179 HMLHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTE 238
Query: 225 EILQEYLEISSLVQ--------DEVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPP 276
EI+ + EI V+ + + +HR AA + E E+ L +
Sbjct: 239 EIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAK----EQEIEFDTSLLEENENLQANE 294
Query: 277 CV--------------TFDESLLEEGEPL---EPGELQLNELTVESVQHTLTSVTDELAV 319
+ T E L++ + L E L+L E +E T +D + +
Sbjct: 295 IMWNNLTAESLQVMLKTLAEELMQTQQMLLNKEEAVLEL-EKRIEESSETCEKKSDIVLL 353
Query: 320 ------------------ATEMVFRRQ-EMVTQLQQE--------LRNEEENTHP---RE 349
TE F Q E++ Q QE + N EE+ E
Sbjct: 354 LSQKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSME 413
Query: 350 RVQLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHST 409
R + L K + ++ ++ G+ + S A +++ + L + + + +
Sbjct: 414 RKERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQEL 473
Query: 410 SSSEQE---REGGRTPTLEILKSHISGIFR----PKFSNLYRLEGEGFPSIPLLIDHLLS 462
+ + RE P +L + G R N+YR EG GF +IP LIDH +
Sbjct: 474 LKKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYT 533
Query: 463 TQQPLTKKSGVVLHRAVPKDK-WVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKS 521
T+Q +TKKSGVVL +PKDK W+L+HED++LGE +G+GNFGEV+ G L+ D T VAVK+
Sbjct: 534 TKQVITKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLK-DKTSVAVKT 592
Query: 522 CRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTE 581
C+E LP +LK KFLQEA+ILKQY HPNIV+LIGVCTQ+QP+YI+MELV GGDFLTFLR +
Sbjct: 593 CKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRK 652
Query: 582 GARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADG 641
L++K L++ DAAAGM YLESK CIHRDLAARNCLV E NVLKISDFGMSR+E G
Sbjct: 653 KDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGG 712
Query: 642 VYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTRE 701
VY++S GL+Q+P+KWTAPEALNYGRYSSESDVWSFGILLWETFSLG PYP ++NQQ RE
Sbjct: 713 VYSSS-GLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQARE 771
Query: 702 FVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKR 750
VE+G R+ P+ CP+ + ++M +CW Y+P RP FS + +EL I+++
Sbjct: 772 QVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRK 820
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 238 bits (607), Expect = 2e-62
Identities = 121/294 (41%), Positives = 183/294 (62%), Gaps = 8/294 (2%)
Query: 458 DHLLST-QQPLTKKSGVVLHRAVPK-DKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNT 515
D L++T P K++ ++ P DKW + D+ + ++G G +GEV+ G + +
Sbjct: 207 DGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSL 266
Query: 516 LVAVKSCRE-TLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDF 574
VAVK+ +E T+ + +FL+EA ++K+ HPN+V+L+GVCT++ P YI+ E + G+
Sbjct: 267 TVAVKTLKEDTMEVE---EFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNL 323
Query: 575 LTFLRT-EGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFG 633
L +LR + LL M ++ MEYLE K IHRDLAARNCLV E +++K++DFG
Sbjct: 324 LDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFG 383
Query: 634 MSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPN 693
+SR Y A G + P+KWTAPE+L Y ++S +SDVW+FG+LLWE + G SPYP
Sbjct: 384 LSRLMTGDTYTAHAGAK-FPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPG 442
Query: 694 LSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSI 747
+ Q E +EK R+ PE CP+ V+ LM CW + P RPSF+ I+Q +++
Sbjct: 443 IDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETM 496
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 238 bits (607), Expect = 2e-62
Identities = 121/294 (41%), Positives = 183/294 (62%), Gaps = 8/294 (2%)
Query: 458 DHLLST-QQPLTKKSGVVLHRAVPK-DKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNT 515
D L++T P K++ ++ P DKW + D+ + ++G G +GEV+ G + +
Sbjct: 226 DGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSL 285
Query: 516 LVAVKSCRE-TLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDF 574
VAVK+ +E T+ + +FL+EA ++K+ HPN+V+L+GVCT++ P YI+ E + G+
Sbjct: 286 TVAVKTLKEDTMEVE---EFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNL 342
Query: 575 LTFLRT-EGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFG 633
L +LR + LL M ++ MEYLE K IHRDLAARNCLV E +++K++DFG
Sbjct: 343 LDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFG 402
Query: 634 MSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPN 693
+SR Y A G + P+KWTAPE+L Y ++S +SDVW+FG+LLWE + G SPYP
Sbjct: 403 LSRLMTGDTYTAHAGAK-FPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPG 461
Query: 694 LSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSI 747
+ Q E +EK R+ PE CP+ V+ LM CW + P RPSF+ I+Q +++
Sbjct: 462 IDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETM 515
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 232 bits (591), Expect = 1e-60
Identities = 116/268 (43%), Positives = 168/268 (62%), Gaps = 6/268 (2%)
Query: 482 DKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARI 540
DKW + D+ + ++G G +GEV+ G + + VAVK+ +E T+ + +FL+EA +
Sbjct: 264 DKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVE---EFLKEAAV 320
Query: 541 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAA 599
+K+ HPN+V+L+GVCT + P YIV E + G+ L +LR + LL M ++
Sbjct: 321 MKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISS 380
Query: 600 GMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAP 659
MEYLE K IHRDLAARNCLV E +V+K++DFG+SR Y A G + P+KWTAP
Sbjct: 381 AMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAP 439
Query: 660 EALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAV 719
E+L Y +S +SDVW+FG+LLWE + G SPYP + Q + +EKG R+ PE CP V
Sbjct: 440 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 499
Query: 720 FRLMEQCWAYEPGQRPSFSTIYQELQSI 747
+ LM CW + P RPSF+ +Q +++
Sbjct: 500 YELMRACWKWSPADRPSFAETHQAFETM 527
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 232 bits (591), Expect = 1e-60
Identities = 116/268 (43%), Positives = 168/268 (62%), Gaps = 6/268 (2%)
Query: 482 DKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARI 540
DKW + D+ + ++G G +GEV+ G + + VAVK+ +E T+ + +FL+EA +
Sbjct: 279 DKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVE---EFLKEAAV 335
Query: 541 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAA 599
+K+ HPN+V+L+GVCT + P YIV E + G+ L +LR + LL M ++
Sbjct: 336 MKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISS 395
Query: 600 GMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAP 659
MEYLE K IHRDLAARNCLV E +V+K++DFG+SR Y A G + P+KWTAP
Sbjct: 396 AMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAP 454
Query: 660 EALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAV 719
E+L Y +S +SDVW+FG+LLWE + G SPYP + Q + +EKG R+ PE CP V
Sbjct: 455 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 514
Query: 720 FRLMEQCWAYEPGQRPSFSTIYQELQSI 747
+ LM CW + P RPSF+ +Q +++
Sbjct: 515 YELMRACWKWSPADRPSFAETHQAFETM 542
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 232 bits (591), Expect = 1e-60
Identities = 116/268 (43%), Positives = 168/268 (62%), Gaps = 6/268 (2%)
Query: 482 DKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARI 540
DKW + D+ + ++G G +GEV+ G + + VAVK+ +E T+ + +FL+EA +
Sbjct: 258 DKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVE---EFLKEAAV 314
Query: 541 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAA 599
+K+ HPN+V+L+GVCT + P YIV E + G+ L +LR + LL M ++
Sbjct: 315 MKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISS 374
Query: 600 GMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAP 659
MEYLE K IHRDLAARNCLV E +V+K++DFG+SR Y A G + P+KWTAP
Sbjct: 375 AMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAP 433
Query: 660 EALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAV 719
E+L Y +S +SDVW+FG+LLWE + G SPYP + Q + +EKG R+ PE CP V
Sbjct: 434 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 493
Query: 720 FRLMEQCWAYEPGQRPSFSTIYQELQSI 747
+ LM CW + P RPSF+ +Q +++
Sbjct: 494 YELMRACWKWSPADRPSFAETHQAFETM 521
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 232 bits (591), Expect = 1e-60
Identities = 116/268 (43%), Positives = 168/268 (62%), Gaps = 6/268 (2%)
Query: 482 DKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARI 540
DKW + D+ + ++G G +GEV+ G + + VAVK+ +E T+ + +FL+EA +
Sbjct: 264 DKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVE---EFLKEAAV 320
Query: 541 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAA 599
+K+ HPN+V+L+GVCT + P YIV E + G+ L +LR + LL M ++
Sbjct: 321 MKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISS 380
Query: 600 GMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAP 659
MEYLE K IHRDLAARNCLV E +V+K++DFG+SR Y A G + P+KWTAP
Sbjct: 381 AMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAP 439
Query: 660 EALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAV 719
E+L Y +S +SDVW+FG+LLWE + G SPYP + Q + +EKG R+ PE CP V
Sbjct: 440 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 499
Query: 720 FRLMEQCWAYEPGQRPSFSTIYQELQSI 747
+ LM CW + P RPSF+ +Q +++
Sbjct: 500 YELMRACWKWSPADRPSFAETHQAFETM 527
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 232 bits (591), Expect = 1e-60
Identities = 116/268 (43%), Positives = 168/268 (62%), Gaps = 6/268 (2%)
Query: 482 DKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARI 540
DKW + D+ + ++G G +GEV+ G + + VAVK+ +E T+ + +FL+EA +
Sbjct: 243 DKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVE---EFLKEAAV 299
Query: 541 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAA 599
+K+ HPN+V+L+GVCT + P YIV E + G+ L +LR + LL M ++
Sbjct: 300 MKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISS 359
Query: 600 GMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAP 659
MEYLE K IHRDLAARNCLV E +V+K++DFG+SR Y A G + P+KWTAP
Sbjct: 360 AMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAP 418
Query: 660 EALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAV 719
E+L Y +S +SDVW+FG+LLWE + G SPYP + Q + +EKG R+ PE CP V
Sbjct: 419 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 478
Query: 720 FRLMEQCWAYEPGQRPSFSTIYQELQSI 747
+ LM CW + P RPSF+ +Q +++
Sbjct: 479 YELMRACWKWSPADRPSFAETHQAFETM 506
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 226 bits (577), Expect = 5e-59
Identities = 123/262 (46%), Positives = 160/262 (61%), Gaps = 12/262 (4%)
Query: 484 WVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQ 543
W+LN + L LG QIG G FG V G V C T FL E ++ +
Sbjct: 187 WLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQA-----FLDETAVMTK 241
Query: 544 YSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEG-ARLRVKTLLQMVGDAAAGME 602
H N+VRL+GV Q +YIVME V G+ + FLRT G A + LLQ A GME
Sbjct: 242 MQHENLVRLLGVILH-QGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGME 300
Query: 603 YLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEAL 662
YLESK +HRDLAARN LV+E V K+SDFG+++ E G+ ++ ++PVKWTAPEAL
Sbjct: 301 YLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSS-----RLPVKWTAPEAL 355
Query: 663 NYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRL 722
+G+++S+SDVWSFG+LLWE FS G +PYP +S ++ E VEKG R+ PE CP V L
Sbjct: 356 KHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVL 415
Query: 723 MEQCWAYEPGQRPSFSTIYQEL 744
M CW EP +RP F + ++L
Sbjct: 416 MSSCWEAEPARRPPFRKLAEKL 437
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 226 bits (577), Expect = 5e-59
Identities = 123/262 (46%), Positives = 160/262 (61%), Gaps = 12/262 (4%)
Query: 484 WVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQ 543
W+LN + L LG QIG G FG V G V C T FL E ++ +
Sbjct: 229 WLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQA-----FLDETAVMTK 283
Query: 544 YSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEG-ARLRVKTLLQMVGDAAAGME 602
H N+VRL+GV Q +YIVME V G+ + FLRT G A + LLQ A GME
Sbjct: 284 MQHENLVRLLGVILH-QGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGME 342
Query: 603 YLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEAL 662
YLESK +HRDLAARN LV+E V K+SDFG+++ E G+ ++ ++PVKWTAPEAL
Sbjct: 343 YLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSS-----RLPVKWTAPEAL 397
Query: 663 NYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRL 722
+G+++S+SDVWSFG+LLWE FS G +PYP +S ++ E VEKG R+ PE CP V L
Sbjct: 398 KHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVL 457
Query: 723 MEQCWAYEPGQRPSFSTIYQEL 744
M CW EP +RP F + ++L
Sbjct: 458 MSSCWEAEPARRPPFRKLAEKL 479
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 226 bits (577), Expect = 5e-59
Identities = 123/262 (46%), Positives = 160/262 (61%), Gaps = 12/262 (4%)
Query: 484 WVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQ 543
W+LN + L LG QIG G FG V G V C T FL E ++ +
Sbjct: 228 WLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQA-----FLDETAVMTK 282
Query: 544 YSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEG-ARLRVKTLLQMVGDAAAGME 602
H N+VRL+GV Q +YIVME V G+ + FLRT G A + LLQ A GME
Sbjct: 283 MQHENLVRLLGVILH-QGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGME 341
Query: 603 YLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEAL 662
YLESK +HRDLAARN LV+E V K+SDFG+++ E G+ ++ ++PVKWTAPEAL
Sbjct: 342 YLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSS-----RLPVKWTAPEAL 396
Query: 663 NYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRL 722
+G+++S+SDVWSFG+LLWE FS G +PYP +S ++ E VEKG R+ PE CP V L
Sbjct: 397 KHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVL 456
Query: 723 MEQCWAYEPGQRPSFSTIYQEL 744
M CW EP +RP F + ++L
Sbjct: 457 MSSCWEAEPARRPPFRKLAEKL 478
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 226 bits (575), Expect = 8e-59
Identities = 124/314 (39%), Positives = 178/314 (56%), Gaps = 13/314 (4%)
Query: 443 YRLEGEGFPSIPLLIDH--------LLSTQQPLTKKS-GVVLHRAVPKDKWVLNHEDLVL 493
Y E F SIP +I++ + + P++ K +KW +N +L
Sbjct: 313 YLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTF 372
Query: 494 GEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLI 553
++G G FG V G+ RA VA+K+ RE + F++EA+++ + +HP +V+L
Sbjct: 373 MRELGSGLFGVVRLGKWRAQYK-VAIKAIREGAM--CEEDFIEEAKVMMKLTHPKLVQLY 429
Query: 554 GVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRD 613
GVCTQ++PIYIV E ++ G L FLR LL M D GMEYLE IHRD
Sbjct: 430 GVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRD 489
Query: 614 LAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDV 673
LAARNCLV+E V+K+SDFGM+R D Y +S G + PVKW PE NY R+SS+SDV
Sbjct: 490 LAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAK-FPVKWCPPEVFNYSRFSSKSDV 548
Query: 674 WSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQ 733
WSFG+L+WE F+ G P+ +N + V +G RL P+L + V+ +M +CW +P
Sbjct: 549 WSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEG 608
Query: 734 RPSFSTIYQELQSI 747
RPSF + + + +
Sbjct: 609 RPSFEDLLRTIDEL 622
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 225 bits (573), Expect = 1e-58
Identities = 118/266 (44%), Positives = 161/266 (60%), Gaps = 6/266 (2%)
Query: 483 KWVLNHEDLVLGEQIGRGNFGEVFSGR-LRADNTLVAVKSCRETLPPDLKAKFLQEARIL 541
KWV++ +L ++IG G FG V G L D VA+K+ RE + F++EA ++
Sbjct: 355 KWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDK--VAIKTIREGAMSE--EDFIEEAEVM 410
Query: 542 KQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGM 601
+ SHP +V+L GVC ++ PI +V E ++ G +LRT+ +TLL M D GM
Sbjct: 411 MKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGM 470
Query: 602 EYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEA 661
YLE C IHRDLAARNCLV E V+K+SDFGM+R D Y +S G + PVKW +PE
Sbjct: 471 AYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTK-FPVKWASPEV 529
Query: 662 LNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFR 721
++ RYSS+SDVWSFG+L+WE FS G PY N SN + E + G RL P L V++
Sbjct: 530 FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQ 589
Query: 722 LMEQCWAYEPGQRPSFSTIYQELQSI 747
+M CW P RP+FS + ++L I
Sbjct: 590 IMNHCWKERPEDRPAFSRLLRQLAEI 615
>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 223 bits (569), Expect = 4e-58
Identities = 127/323 (39%), Positives = 185/323 (57%), Gaps = 15/323 (4%)
Query: 440 SNLYRLEGEGFPSIPLLIDH--------LLSTQQPLTKKSGVVLHR-AVPKDKWVLNHED 490
+ LY E F SIP LI + + + P++ K+ V ++ W L E+
Sbjct: 357 NKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREE 416
Query: 491 LVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYSHPNI 549
+ L +++G G FG V G+ + VAVK +E ++ D +F QEA+ + + SHP +
Sbjct: 417 ITLLKELGSGQFGVVQLGKWKGQYD-VAVKMIKEGSMSED---EFFQEAQTMMKLSHPKL 472
Query: 550 VRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCC 609
V+ GVC+++ PIYIV E + G L +LR+ G L LL+M D GM +LES
Sbjct: 473 VKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQF 532
Query: 610 IHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSS 669
IHRDLAARNCLV +K+SDFGM+R D Y +S G + PVKW+APE +Y +YSS
Sbjct: 533 IHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTK-FPVKWSAPEVFHYFKYSS 591
Query: 670 ESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAY 729
+SDVW+FGIL+WE FSLG PY N Q V +G RL P L D ++++M CW
Sbjct: 592 KSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHE 651
Query: 730 EPGQRPSFSTIYQELQSIRKRHR 752
P +RP+F + ++ +R++ +
Sbjct: 652 LPEKRPTFQQLLSSIEPLREKDK 674
>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 223 bits (569), Expect = 4e-58
Identities = 127/323 (39%), Positives = 185/323 (57%), Gaps = 15/323 (4%)
Query: 440 SNLYRLEGEGFPSIPLLIDH--------LLSTQQPLTKKSGVVLHR-AVPKDKWVLNHED 490
+ LY E F SIP LI + + + P++ K+ V ++ W L E+
Sbjct: 357 NKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREE 416
Query: 491 LVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYSHPNI 549
+ L +++G G FG V G+ + VAVK +E ++ D +F QEA+ + + SHP +
Sbjct: 417 ITLLKELGSGQFGVVQLGKWKGQYD-VAVKMIKEGSMSED---EFFQEAQTMMKLSHPKL 472
Query: 550 VRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCC 609
V+ GVC+++ PIYIV E + G L +LR+ G L LL+M D GM +LES
Sbjct: 473 VKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQF 532
Query: 610 IHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSS 669
IHRDLAARNCLV +K+SDFGM+R D Y +S G + PVKW+APE +Y +YSS
Sbjct: 533 IHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTK-FPVKWSAPEVFHYFKYSS 591
Query: 670 ESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAY 729
+SDVW+FGIL+WE FSLG PY N Q V +G RL P L D ++++M CW
Sbjct: 592 KSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHE 651
Query: 730 EPGQRPSFSTIYQELQSIRKRHR 752
P +RP+F + ++ +R++ +
Sbjct: 652 LPEKRPTFQQLLSSIEPLREKDK 674
>gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
Length = 1620
Score = 220 bits (561), Expect = 3e-57
Identities = 116/271 (42%), Positives = 163/271 (60%), Gaps = 14/271 (5%)
Query: 489 EDLVLGEQIGRGNFGEVFSGRLRA-----DNTLVAVKSCRETLPPDLKAKFLQEARILKQ 543
+++ L +G G FGEV+ G++ VAVK+ E + FL EA I+ +
Sbjct: 1114 KNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISK 1173
Query: 544 YSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLR------TEGARLRVKTLLQMVGDA 597
++H NIVR IGV Q P +I++EL+ GGD +FLR ++ + L + LL + D
Sbjct: 1174 FNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDI 1233
Query: 598 AAGMEYLESKCCIHRDLAARNCLVT---EKNVLKISDFGMSREEADGVYAASGGLRQVPV 654
A G +YLE IHRD+AARNCL+T V KI DFGM+R+ Y GG +PV
Sbjct: 1234 ACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPV 1293
Query: 655 KWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPEL 714
KW PEA G ++S++D WSFG+LLWE FSLG PYP+ SNQ+ EFV GGR+ P+
Sbjct: 1294 KWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKN 1353
Query: 715 CPDAVFRLMEQCWAYEPGQRPSFSTIYQELQ 745
CP V+R+M QCW ++P RP+F+ I + ++
Sbjct: 1354 CPGPVYRIMTQCWQHQPEDRPNFAIILERIE 1384
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 220 bits (561), Expect = 3e-57
Identities = 133/377 (35%), Positives = 204/377 (54%), Gaps = 16/377 (4%)
Query: 381 QELLQTKLEHLGPGEPPP-VLLLQDDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKF 439
+ + + + EHL E +++D RH S + G R T +K + I +
Sbjct: 153 RNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHY--QIKKNDS 210
Query: 440 SNLYRLEGEGFPSIPLLI---DHLLSTQQPLTKKSGVVLHRAVPK------DKWVLNHED 490
Y E F SIP LI H + + ++ +P +KW ++ +
Sbjct: 211 GQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSE 270
Query: 491 LVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIV 550
L ++IG G FG V G R+ + VA+K+ E + F++EA+++ + SH +V
Sbjct: 271 LAFIKEIGSGQFGVVHLGEWRS-HIQVAIKAINEGSMSE--EDFIEEAKVMMKLSHSKLV 327
Query: 551 RLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCI 610
+L GVC Q++P+YIV E ++ G L +LR +LR + LL + D GMEYLE I
Sbjct: 328 QLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYI 387
Query: 611 HRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSE 670
HRDLAARNCLV+ ++KISDFGM+R D Y +S G + P+KW+ PE + +YSS+
Sbjct: 388 HRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAK-FPIKWSPPEVFLFNKYSSK 446
Query: 671 SDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYE 730
SDVWSFG+L+WE F+ G P+ N SN Q E + +G RL P L P +++ +M CW +
Sbjct: 447 SDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEK 506
Query: 731 PGQRPSFSTIYQELQSI 747
P RP+F+ + + + I
Sbjct: 507 PEGRPTFAELLRAVTEI 523
>gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]
Length = 2347
Score = 220 bits (560), Expect = 4e-57
Identities = 118/277 (42%), Positives = 167/277 (60%), Gaps = 17/277 (6%)
Query: 489 EDLVLGEQIGRGNFGEVFSGR------LRADNTLVAVKSCRETLPPDLKAKFLQEARILK 542
E L L +G G FGEV+ G + + VAVK+ ++ K +FL+EA ++
Sbjct: 1943 EKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMS 2002
Query: 543 QYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTE------GARLRVKTLLQMVGD 596
+++HPNI++ +GVC +P YI++EL++GGD LT+LR G L + L+ + D
Sbjct: 2003 KFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVD 2062
Query: 597 AAAGMEYLESKCCIHRDLAARNCLVTEKN-----VLKISDFGMSREEADGVYAASGGLRQ 651
+ G YLE IHRDLAARNCLV+ K+ ++KI DFG++R+ Y G
Sbjct: 2063 ISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGL 2122
Query: 652 VPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPC 711
+PV+W APE+L G ++++SDVWSFGIL+WE +LG PYP SN +V+ GGRL
Sbjct: 2123 LPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEP 2182
Query: 712 PELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIR 748
P CPD ++ LM QCWA EP QRP+F I +LQ R
Sbjct: 2183 PRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFR 2219
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 218 bits (556), Expect = 1e-56
Identities = 108/278 (38%), Positives = 165/278 (59%), Gaps = 14/278 (5%)
Query: 482 DKWVLNHEDLVLGEQIGRGNFGEVFSGRLRA-----DNTLVAVKSCRETLPPDLKAKFLQ 536
D+W + E + + ++G+G+FG V+ G + T VA+K+ E + +FL
Sbjct: 990 DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLN 1049
Query: 537 EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLR---------V 587
EA ++K+++ ++VRL+GV +Q QP ++MEL+ GD ++LR+ + +
Sbjct: 1050 EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSL 1109
Query: 588 KTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASG 647
++QM G+ A GM YL + +HRDLAARNC+V E +KI DFGM+R+ + Y G
Sbjct: 1110 SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKG 1169
Query: 648 GLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGG 707
G +PV+W +PE+L G +++ SDVWSFG++LWE +L PY LSN+Q FV +GG
Sbjct: 1170 GKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGG 1229
Query: 708 RLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQ 745
L P+ CPD +F LM CW Y P RPSF I ++
Sbjct: 1230 LLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIK 1267
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 217 bits (553), Expect = 3e-56
Identities = 125/317 (39%), Positives = 185/317 (58%), Gaps = 13/317 (4%)
Query: 441 NLYRLEGEGFPSIPLLIDHLLST----QQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQ 496
+LY +G FP + L+ + + Q PL + + +A +D W H + LG +
Sbjct: 178 SLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPC--MPQKAPRQDVWERPHSEFALGRK 235
Query: 497 IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFL-QEARILKQYSHPNIVRLIGV 555
+G G FGEV+ G L + VA+K + ++K L +E + LK H ++RL V
Sbjct: 236 LGEGYFGEVWEG-LWLGSLPVAIKVIKSA---NMKLTDLAKEIQTLKGLRHERLIRLHAV 291
Query: 556 CTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDL 614
C+ +P+YIV EL++ G+ FL T EG LR+ LL A GM YLE + +HRDL
Sbjct: 292 CSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDL 351
Query: 615 AARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVW 674
AARN LV + K++DFG++R D +Y+ S + +PVKWTAPEA NY +S +SDVW
Sbjct: 352 AARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSK-IPVKWTAPEAANYRVFSQKSDVW 410
Query: 675 SFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQR 734
SFG+LL E F+ G PY ++N +T + + +G RLP P CP V+ LM +CW P +R
Sbjct: 411 SFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEER 470
Query: 735 PSFSTIYQELQSIRKRH 751
PSF+T+ ++L +I + H
Sbjct: 471 PSFATLREKLHAIHRCH 487
>gi|221316650 ephrin receptor EphA1 [Homo sapiens]
Length = 976
Score = 215 bits (548), Expect = 1e-55
Identities = 110/262 (41%), Positives = 163/262 (62%), Gaps = 7/262 (2%)
Query: 491 LVLGEQIGRGNFGEVFSGRLRA---DNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHP 547
L++ IG G FGEV+ G LR D VA+K+ ++T P FL+EA I+ Q+SHP
Sbjct: 624 LMVDTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHP 683
Query: 548 NIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESK 607
+I+ L GV T+++PI I+ E ++ G FLR +L L+ M+ A+GM YL +
Sbjct: 684 HILHLEGVVTKRKPIMIITEFMENGALDAFLREREDQLVPGQLVAMLQGIASGMNYLSNH 743
Query: 608 CCIHRDLAARNCLVTEKNVLKISDFGMSR--EEADGVYAASGGLRQVPVKWTAPEALNYG 665
+HRDLAARN LV + K+SDFG++R ++ DG Y GG ++P++WTAPEA+ +
Sbjct: 744 NYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGG--KIPIRWTAPEAIAHR 801
Query: 666 RYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQ 725
+++ SDVWSFGI++WE S G PY +SNQ+ + +E G RLP P CP ++ LM+
Sbjct: 802 IFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKN 861
Query: 726 CWAYEPGQRPSFSTIYQELQSI 747
CWAY+ +RP F + L+ +
Sbjct: 862 CWAYDRARRPHFQKLQAHLEQL 883
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 214 bits (546), Expect = 2e-55
Identities = 106/265 (40%), Positives = 166/265 (62%), Gaps = 6/265 (2%)
Query: 484 WVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILK 542
W ++ +DL +++G G FG V G+ R VA+K +E ++ D +F++EA+++
Sbjct: 395 WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYD-VAIKMIKEGSMSED---EFIEEAKVMM 450
Query: 543 QYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGME 602
SH +V+L GVCT+++PI+I+ E + G L +LR R + + LL+M D ME
Sbjct: 451 NLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAME 510
Query: 603 YLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEAL 662
YLESK +HRDLAARNCLV ++ V+K+SDFG+SR D Y +S G + PV+W+ PE L
Sbjct: 511 YLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVG-SKFPVRWSPPEVL 569
Query: 663 NYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRL 722
Y ++SS+SD+W+FG+L+WE +SLG PY +N +T E + +G RL P L + V+ +
Sbjct: 570 MYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTI 629
Query: 723 MEQCWAYEPGQRPSFSTIYQELQSI 747
M CW + +RP+F + + +
Sbjct: 630 MYSCWHEKADERPTFKILLSNILDV 654
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 213 bits (543), Expect = 4e-55
Identities = 122/307 (39%), Positives = 178/307 (57%), Gaps = 17/307 (5%)
Query: 450 FPSIPLLIDHLLSTQQPLTKKSGVVLHRAVP---------KDKWVLNHEDLVLGEQIGRG 500
F ++ L+ H L + V H+ +P KD W + E L L +++G G
Sbjct: 221 FETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNG 280
Query: 501 NFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQK 559
FGEV+ G NT VA+K+ + T+ P+ FL+EA+I+K+ H +V+L V ++
Sbjct: 281 QFGEVWMGTWNG-NTKVAIKTLKPGTMSPE---SFLEEAQIMKKLKHDKLVQLYAVVSE- 335
Query: 560 QPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARN 618
+PIYIV E + G L FL+ EG L++ L+ M AAGM Y+E IHRDL + N
Sbjct: 336 EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSAN 395
Query: 619 CLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGI 678
LV + KI+DFG++R D Y A G + P+KWTAPEA YGR++ +SDVWSFGI
Sbjct: 396 ILVGNGLICKIADFGLARLIEDNEYTARQGAK-FPIKWTAPEAALYGRFTIKSDVWSFGI 454
Query: 679 LLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFS 738
LL E + G PYP ++N++ E VE+G R+PCP+ CP ++ LM CW +P +RP+F
Sbjct: 455 LLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFE 514
Query: 739 TIYQELQ 745
+ L+
Sbjct: 515 YLQSFLE 521
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 211 bits (536), Expect = 3e-54
Identities = 121/289 (41%), Positives = 174/289 (60%), Gaps = 12/289 (4%)
Query: 459 HLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVA 518
H L+T P +K + + KD W + E L L ++G+G FGEV+ G T VA
Sbjct: 242 HRLTTVCPTSKPQT----QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVA 296
Query: 519 VKSCRE-TLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTF 577
+K+ + T+ P+ FLQEA+++K+ H +V+L V ++ +PIYIV E + G L F
Sbjct: 297 IKTLKPGTMSPEA---FLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDF 352
Query: 578 LRTE-GARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSR 636
L+ E G LR+ L+ M A+GM Y+E +HRDL A N LV E V K++DFG++R
Sbjct: 353 LKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLAR 412
Query: 637 EEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSN 696
D Y A G + P+KWTAPEA YGR++ +SDVWSFGILL E + G PYP + N
Sbjct: 413 LIEDNEYTARQGAK-FPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVN 471
Query: 697 QQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQ 745
++ + VE+G R+PCP CP+++ LM QCW EP +RP+F + L+
Sbjct: 472 REVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 211 bits (536), Expect = 3e-54
Identities = 121/289 (41%), Positives = 174/289 (60%), Gaps = 12/289 (4%)
Query: 459 HLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVA 518
H L+T P +K + + KD W + E L L ++G+G FGEV+ G T VA
Sbjct: 242 HRLTTVCPTSKPQT----QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVA 296
Query: 519 VKSCRE-TLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTF 577
+K+ + T+ P+ FLQEA+++K+ H +V+L V ++ +PIYIV E + G L F
Sbjct: 297 IKTLKPGTMSPEA---FLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDF 352
Query: 578 LRTE-GARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSR 636
L+ E G LR+ L+ M A+GM Y+E +HRDL A N LV E V K++DFG++R
Sbjct: 353 LKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLAR 412
Query: 637 EEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSN 696
D Y A G + P+KWTAPEA YGR++ +SDVWSFGILL E + G PYP + N
Sbjct: 413 LIEDNEYTARQGAK-FPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVN 471
Query: 697 QQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQ 745
++ + VE+G R+PCP CP+++ LM QCW EP +RP+F + L+
Sbjct: 472 REVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520
>gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precursor
[Homo sapiens]
Length = 864
Score = 211 bits (536), Expect = 3e-54
Identities = 116/270 (42%), Positives = 161/270 (59%), Gaps = 14/270 (5%)
Query: 490 DLVLGEQIGRGNFGEVFSGR---LRADNT--LVAVKSCRETLPPDLKAKFLQEARILKQY 544
++ L +G G FGEV+ G L D++ VA+K+ E P + FL EA I+ ++
Sbjct: 509 NVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKF 568
Query: 545 SHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT------EGARLRVKTLLQMVGDAA 598
H NIVR +G+ + P I++EL+ GGD +FLR + + L ++ LLQ+ D A
Sbjct: 569 RHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIA 628
Query: 599 AGMEYLESKCCIHRDLAARNCLVT---EKNVLKISDFGMSREEADGVYAASGGLRQVPVK 655
G YLE IHRD+AARNCL++ V KI DFGM+R+ Y G +PVK
Sbjct: 629 QGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVK 688
Query: 656 WTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELC 715
W PEA G ++S++D WSFG+LLWE FSLG PYP +NQ+ +FV GGR+ P C
Sbjct: 689 WMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGC 748
Query: 716 PDAVFRLMEQCWAYEPGQRPSFSTIYQELQ 745
P V+R+M QCW +EP RPSF++I + LQ
Sbjct: 749 PGPVYRIMTQCWQHEPELRPSFASILERLQ 778
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,425,416
Number of Sequences: 37866
Number of extensions: 1349265
Number of successful extensions: 9140
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 606
Number of HSP's successfully gapped in prelim test: 486
Number of HSP's that attempted gapping in prelim test: 5913
Number of HSP's gapped (non-prelim): 2059
length of query: 752
length of database: 18,247,518
effective HSP length: 110
effective length of query: 642
effective length of database: 14,082,258
effective search space: 9040809636
effective search space used: 9040809636
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.