Guide to the Human Genome
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Search of human proteins with 11386137

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1
precursor [Homo sapiens]
         (908 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1 ...  1825   0.0  
gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2 ...  1719   0.0  
gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor ...  1483   0.0  
gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2 ...  1438   0.0  
gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1 p...  1409   0.0  
gi|29029597 glutamate receptor KA2 precursor [Homo sapiens]           725   0.0  
gi|29029595 glutamate receptor KA1 precursor [Homo sapiens]           705   0.0  
gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [H...   623   e-178
gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [H...   622   e-178
gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1 pre...   615   e-176
gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2 pr...   614   e-175
gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1 p...   611   e-175
gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2 p...   611   e-174
gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [H...   609   e-174
gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1 p...   593   e-169
gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2 p...   586   e-167
gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [H...   362   1e-99
gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens]   357   3e-98
gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]    258   1e-68
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]    257   3e-68
gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]    257   3e-68
gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor ...   192   1e-48
gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2 ...   188   2e-47
gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1 ...   188   2e-47
gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1 pr...   188   2e-47
gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor ...   174   3e-43
gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor [...   171   4e-42
gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartat...   159   1e-38
gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate...   157   3e-38
gi|116284390 glutamate receptor, ionotrophic, AMPA 4 isoform 3 p...   135   2e-31

>gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1
           precursor [Homo sapiens]
          Length = 908

 Score = 1825 bits (4727), Expect = 0.0
 Identities = 908/908 (100%), Positives = 908/908 (100%)

Query: 1   MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFA 60
           MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFA
Sbjct: 1   MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFA 60

Query: 61  VNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQS 120
           VNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQS
Sbjct: 61  VNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQS 120

Query: 121 ICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDST 180
           ICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDST
Sbjct: 121 ICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDST 180

Query: 181 GLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILK 240
           GLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILK
Sbjct: 181 GLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILK 240

Query: 241 QALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMER 300
           QALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMER
Sbjct: 241 QALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMER 300

Query: 301 LQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFM 360
           LQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFM
Sbjct: 301 LQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFM 360

Query: 361 SLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGK 420
           SLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGK
Sbjct: 361 SLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGK 420

Query: 421 PANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI 480
           PANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI
Sbjct: 421 PANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI 480

Query: 481 RLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISI 540
           RLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISI
Sbjct: 481 RLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISI 540

Query: 541 LYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSD 600
           LYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSD
Sbjct: 541 LYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSD 600

Query: 601 VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT 660
           VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT
Sbjct: 601 VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT 660

Query: 661 VERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKS 720
           VERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKS
Sbjct: 661 VERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKS 720

Query: 721 NEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITI 780
           NEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITI
Sbjct: 721 NEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITI 780

Query: 781 AILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVG 840
           AILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVG
Sbjct: 781 AILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVG 840

Query: 841 EFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRR 900
           EFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRR
Sbjct: 841 EFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRR 900

Query: 901 LPGKETMA 908
           LPGKETMA
Sbjct: 901 LPGKETMA 908


>gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2
           precursor [Homo sapiens]
          Length = 869

 Score = 1719 bits (4451), Expect = 0.0
 Identities = 855/856 (99%), Positives = 855/856 (99%)

Query: 1   MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFA 60
           MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFA
Sbjct: 1   MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFA 60

Query: 61  VNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQS 120
           VNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQS
Sbjct: 61  VNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQS 120

Query: 121 ICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDST 180
           ICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDST
Sbjct: 121 ICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDST 180

Query: 181 GLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILK 240
           GLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILK
Sbjct: 181 GLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILK 240

Query: 241 QALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMER 300
           QALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMER
Sbjct: 241 QALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMER 300

Query: 301 LQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFM 360
           LQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFM
Sbjct: 301 LQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFM 360

Query: 361 SLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGK 420
           SLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGK
Sbjct: 361 SLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGK 420

Query: 421 PANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI 480
           PANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI
Sbjct: 421 PANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI 480

Query: 481 RLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISI 540
           RLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISI
Sbjct: 481 RLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISI 540

Query: 541 LYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSD 600
           LYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSD
Sbjct: 541 LYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSD 600

Query: 601 VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT 660
           VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT
Sbjct: 601 VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT 660

Query: 661 VERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKS 720
           VERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKS
Sbjct: 661 VERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKS 720

Query: 721 NEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITI 780
           NEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITI
Sbjct: 721 NEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITI 780

Query: 781 AILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVG 840
           AILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVG
Sbjct: 781 AILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVG 840

Query: 841 EFLYKSKKNAQLEKRS 856
           EFLYKSKKNAQLEK S
Sbjct: 841 EFLYKSKKNAQLEKES 856


>gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor
           [Homo sapiens]
          Length = 919

 Score = 1483 bits (3840), Expect = 0.0
 Identities = 719/894 (80%), Positives = 808/894 (90%), Gaps = 7/894 (0%)

Query: 19  LLLCLLWIGYSQGTTHVLRFGGIFEYVESGP----MGAEELAFRFAVNTINRNRTLLPNT 74
           LL+C  WI  S+G  HV+R GGIFEY + GP    M AEE AFRF+ N INRNRTLLPNT
Sbjct: 19  LLVCAFWIPDSRGMPHVIRIGGIFEYAD-GPNAQVMNAEEHAFRFSANIINRNRTLLPNT 77

Query: 75  TLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRW 134
           TLTYD Q+I+ +DSFEA+KKACDQL+LGV AIFGPS  S  NAVQSICNAL VPHIQ RW
Sbjct: 78  TLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRW 137

Query: 135 KHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSR 194
           KH   DNKD+FYV+LYPD++SLS AILDLVQ+ KW++ TVVYDDSTGLIRLQELI APSR
Sbjct: 138 KHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSR 197

Query: 195 YNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHY 254
           YN+RLKIRQLP D+ D++PLLKEMKRG+EF +IFDCSH MAA ILKQA+AMGMMTEYYH+
Sbjct: 198 YNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHF 257

Query: 255 IFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDG 314
           IFTTLDL+ALD+EPYRYSGVN+TGFRILN +N  VS+I+EKWSMERLQA P+ +SGLLDG
Sbjct: 258 IFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDG 317

Query: 315 FMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGR 374
            M TDAAL+YDAVH+VSV  Q+ PQMTV+SLQC+RHK WRFG RFM+ IKEA WEGLTGR
Sbjct: 318 VMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGR 377

Query: 375 ITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLI 434
           I FNKT+GLRTDFDLD+ISLKE+GLEK+G W PA GLN+TE  KG+  N+TDSL+NRSLI
Sbjct: 378 IVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLI 437

Query: 435 VTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDA 494
           VTT+LEEP+V+F+KSD+ LYGNDRFEGYCIDLL+EL+ ILGF+YEIRLVEDGKYGAQDD 
Sbjct: 438 VTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDD- 496

Query: 495 NGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFS 554
            GQWNGMV+ELIDHKADLAVAPL IT+VREK IDFSKPFMTLG+SILYRKPNGTNP VFS
Sbjct: 497 KGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFS 556

Query: 555 FLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWF 614
           FLNPLSPDIWMY+LLAYLGVSCVLFVIARFSPYEWY+ HPCNP S+VVENNFTLLNSFWF
Sbjct: 557 FLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWF 616

Query: 615 GVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDL 674
           G+G+LMQQGSELMPKALSTRI+GGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDL
Sbjct: 617 GMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDL 676

Query: 675 AKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYA 734
           AKQTKIEYGAV+DGATMTFFKKSKIST++KMWAFMSS + S LVK+NEEGIQR LT+DYA
Sbjct: 677 AKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSS-KPSALVKNNEEGIQRALTADYA 735

Query: 735 FLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMM 794
            LMESTTIE+VTQRNCNLTQIGGLIDSKGYG+GTPMGSPYRDKITIAILQLQEE KLH+M
Sbjct: 736 LLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIM 795

Query: 795 KEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEK 854
           KEKWWRG+GCPEEE+KEASALG+Q IGGIFIVLAAGLVLSV VAVGEF+YK +K A+ E+
Sbjct: 796 KEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQ 855

Query: 855 RSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA 908
           RSFCS + +E+R SL CQRR+KHKPQ P++VKT+ VINMHTFNDRRLPGK++MA
Sbjct: 856 RSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMA 909


>gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2
           precursor [Homo sapiens]
          Length = 905

 Score = 1438 bits (3722), Expect = 0.0
 Identities = 705/895 (78%), Positives = 799/895 (89%), Gaps = 4/895 (0%)

Query: 14  RRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPN 73
           R T   LL  L     Q    VLR GGIFE VE+ P+  EELAF+FAV +INRNRTL+PN
Sbjct: 15  RDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPN 74

Query: 74  TTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTR 133
           TTLTYD Q+INL+DSFEAS++ACDQL+LGVAA+FGPSHSSS +AVQSICNAL VPHIQTR
Sbjct: 75  TTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTR 134

Query: 134 WKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPS 193
           WKH   DNKD FY++LYPD++++SRAILDLV ++ WKTVTVVY+DSTGLIRLQELIKAPS
Sbjct: 135 WKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPS 194

Query: 194 RYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYH 253
           RYN+++KIRQLP+  KDAKPLLKEMK+GKEF+VIFDCSHE AA ILKQ L MGMMTEYYH
Sbjct: 195 RYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYH 254

Query: 254 YIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLD 313
           Y FTTLDLFALD+E YRYSGVNMTGFR+LN +N  VSSIIEKWSMERLQAPP+P++GLLD
Sbjct: 255 YFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLD 314

Query: 314 GFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTG 373
           G MTT+AALMYDAV++V++A  +  Q+TVSSLQC+RHKPWR G RFM+LIKEA W+GLTG
Sbjct: 315 GMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTG 374

Query: 374 RITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSL 433
            ITFNKTNGLR DFDLD+ISLKEEG EKIG W+  SGLNMT+S K K +NITDSL+NR+L
Sbjct: 375 HITFNKTNGLRKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTL 434

Query: 434 IVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDD 493
           IVTTILEEPYV+++KSDKPLYGNDRFEGYC+DLL+ELS ILGF Y+++LV DGKYGAQ+D
Sbjct: 435 IVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQND 494

Query: 494 ANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVF 553
             G+WNGMV+ELIDH+ADLAVAPL ITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVF
Sbjct: 495 -KGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVF 553

Query: 554 SFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFW 613
           SFLNPLSPDIWMY+LLA LGVSCVLFVIARF+PYEWYNPHPCNPDSDVVENNFTLLNSFW
Sbjct: 554 SFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFW 613

Query: 614 FGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD 673
           FGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD
Sbjct: 614 FGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD 673

Query: 674 LAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDY 733
           LAKQTKIEYGAV DG+TMTFFKKSKISTY+KMWAFMSSR+Q+ LV++++EGIQRVLT+DY
Sbjct: 674 LAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDY 733

Query: 734 AFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHM 793
           A LMEST+IE+VTQRNCNLTQIGGLIDSKGYGVGTP+GSPYRDKITIAILQLQEEGKLHM
Sbjct: 734 ALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHM 793

Query: 794 MKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLE 853
           MKEKWWRGNGCPEE++KEASALGV+NIGGIFIVLAAGLVLSVFVA+GEF+YKS+KN  +E
Sbjct: 794 MKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIE 853

Query: 854 KRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA 908
           +    +A++EEL +SLK Q+++K K +         ++  H    RR   KET+A
Sbjct: 854 QCLSFNAIMEELGISLKNQKKIKKKSRTKGKSSFTSILTCH---QRRTQRKETVA 905


>gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1
           precursor [Homo sapiens]
          Length = 918

 Score = 1409 bits (3647), Expect = 0.0
 Identities = 690/860 (80%), Positives = 774/860 (90%), Gaps = 17/860 (1%)

Query: 14  RRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPN 73
           R T   LL  L     Q    VLR GGIFE VE+ P+  EELAF+FAV +INRNRTL+PN
Sbjct: 15  RDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPN 74

Query: 74  TTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTR 133
           TTLTYD Q+INL+DSFEAS++ACDQL+LGVAA+FGPSHSSS +AVQSICNAL VPHIQTR
Sbjct: 75  TTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTR 134

Query: 134 WKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPS 193
           WKH   DNKD FY++LYPD++++SRAILDLV ++ WKTVTVVY+DSTGLIRLQELIKAPS
Sbjct: 135 WKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPS 194

Query: 194 RYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYH 253
           RYN+++KIRQLP+  KDAKPLLKEMK+GKEF+VIFDCSHE AA ILKQ L MGMMTEYYH
Sbjct: 195 RYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYH 254

Query: 254 YIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLD 313
           Y FTTLDLFALD+E YRYSGVNMTGFR+LN +N  VSSIIEKWSMERLQAPP+P++GLLD
Sbjct: 255 YFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLD 314

Query: 314 GFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTG 373
           G MTT+AALMYDAV++V++A  +  Q+TVSSLQC+RHKPWR G RFM+LIKEA W+GLTG
Sbjct: 315 GMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTG 374

Query: 374 RITFNKTNGLRTDFDLDVISLKEEGLEK---------------IGTWDPASGLNMTESQK 418
            ITFNKTNGLR DFDLD+ISLKEEG EK               IG W+  SGLNMT+S K
Sbjct: 375 HITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNK 434

Query: 419 GKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTY 478
            K +NITDSL+NR+LIVTTILEEPYV+++KSDKPLYGNDRFEGYC+DLL+ELS ILGF Y
Sbjct: 435 DKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIY 494

Query: 479 EIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGI 538
           +++LV DGKYGAQ+D  G+WNGMV+ELIDH+ADLAVAPL ITYVREKVIDFSKPFMTLGI
Sbjct: 495 DVKLVPDGKYGAQND-KGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGI 553

Query: 539 SILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPD 598
           SILYRKPNGTNPGVFSFLNPLSPDIWMY+LLA LGVSCVLFVIARF+PYEWYNPHPCNPD
Sbjct: 554 SILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPD 613

Query: 599 SDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAF 658
           SDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAF
Sbjct: 614 SDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAF 673

Query: 659 LTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLV 718
           LTVERMESPIDSADDLAKQTKIEYGAV DG+TMTFFKKSKISTY+KMWAFMSSR+Q+ LV
Sbjct: 674 LTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALV 733

Query: 719 KSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKI 778
           ++++EGIQRVLT+DYA LMEST+IE+VTQRNCNLTQIGGLIDSKGYGVGTP+GSPYRDKI
Sbjct: 734 RNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKI 793

Query: 779 TIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVA 838
           TIAILQLQEEGKLHMMKEKWWRGNGCPEE++KEASALGV+NIGGIFIVLAAGLVLSVFVA
Sbjct: 794 TIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVA 853

Query: 839 VGEFLYKSKKNAQLEKRSFC 858
           +GEF+YKS+KN  +E ++FC
Sbjct: 854 IGEFIYKSRKNNDIE-QAFC 872


>gi|29029597 glutamate receptor KA2 precursor [Homo sapiens]
          Length = 980

 Score =  725 bits (1871), Expect = 0.0
 Identities = 399/879 (45%), Positives = 552/879 (62%), Gaps = 29/879 (3%)

Query: 20  LLCLLWIGYSQGTTHVL---RFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTL 76
           LL LL + ++  +  VL   R   I +       G E LA   A   IN    +     +
Sbjct: 5   LLLLLIVAFASPSCQVLSSLRMAAILDDQTVCGRG-ERLALALAREQINGIIEVPAKARV 63

Query: 77  TYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHS-SSANAVQSICNALGVPHIQTRWK 135
             D  ++     +E +   C  L  GV ++ GPS S +SA+ V  IC    +PHI+   +
Sbjct: 64  EVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPE 123

Query: 136 HQVSDNKDSFY-VSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSR 194
                    F  VSLYP    +S A+  +++ F + + +++   +  L+RL+EL++    
Sbjct: 124 ETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLI 183

Query: 195 YNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHY 254
               L +R L  D++D  PLLKE++  K   +I D +  ++  IL++A  +GM + +Y Y
Sbjct: 184 SKETLSVRMLD-DSRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFYKY 242

Query: 255 IFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSM---ERLQAPPKPDSGL 311
           I TT+D   L ++       N+ GF + NT +      +   +M   E  +A       L
Sbjct: 243 ILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLGPAL 302

Query: 312 LDGFMTTDAALMYDAVHVVSVAVQQF---PQMTVSSLQCNRHKPWRFGTRFMSLIKEAHW 368
                   AALM+DAVHVV  AV++     ++ V  L C     W  GT  M+ ++   +
Sbjct: 303 -------SAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEY 355

Query: 369 EGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSL 428
           +GLTGR+ FN + G RT++ L ++    +G  +IG W     L M  +      N++ +L
Sbjct: 356 DGLTGRVEFN-SKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLD--INLSQTL 412

Query: 429 SNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKY 488
           +N++L+VTTILE PYV+ + + + L GN+RFEG+C+D+LREL+ +L F Y +RLVEDG Y
Sbjct: 413 ANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLY 472

Query: 489 GAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGT 548
           GA +  NG W GMV ELI+ KADLAVA   IT  REKVIDFSKPFMTLGISILYR   G 
Sbjct: 473 GAPEP-NGSWTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGR 531

Query: 549 NPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPC-NPDSDVVENNFT 607
            PG FSFL+P SP +W+++LLAYL VSCVLF+ AR SPYEWYNPHPC      ++EN +T
Sbjct: 532 KPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYT 591

Query: 608 LLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESP 667
           L NS WF VG  MQQGSE+MP+ALSTR V G+WW FTLIIISSYTANLAAFLTV+RME P
Sbjct: 592 LGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVP 651

Query: 668 IDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQR 727
           ++SADDLA QT IEYG +  G+TMTFF+ S+  TY +MW +M S++ SV VKS EEGI R
Sbjct: 652 VESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIAR 711

Query: 728 VLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQE 787
           VL S YAFL+EST  E+  + NCNLTQIGGL+D+KGYG+G P+GSP+RD+IT+AILQLQE
Sbjct: 712 VLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQE 771

Query: 788 EGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSK 847
             +L ++K KWW G  CP+EE   A  LG++NIGGIFIVL  GL+++VFVAV EF++ ++
Sbjct: 772 NNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTR 831

Query: 848 KNAQLEKRSFCSAMVEELRMSLKCQR----RLKHKPQAP 882
           ++A+ E+ S C  M++ELR ++ C++    R + +P  P
Sbjct: 832 RSAESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRPGGP 870


>gi|29029595 glutamate receptor KA1 precursor [Homo sapiens]
          Length = 956

 Score =  705 bits (1819), Expect = 0.0
 Identities = 395/907 (43%), Positives = 551/907 (60%), Gaps = 32/907 (3%)

Query: 14  RRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPN 73
           R +  L+L   W+     + H LR   I +       G E L+   A N INR    L  
Sbjct: 3   RVSAPLVLLPAWLVMVACSPHSLRIAAILDDPMECSRG-ERLSITLAKNRINRAPERLGK 61

Query: 74  TTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHS-SSANAVQSICNALGVPHIQT 132
             +  D  ++     +E ++  C  L  GV A+ GPS S +S++ + +IC    VPH + 
Sbjct: 62  AKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKV 121

Query: 133 RWKHQVSDNKDSFY-VSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKA 191
             +  V      F  ++L+P  + +S A+  ++ FF   T  ++   +  L+ L++L++ 
Sbjct: 122 APEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQ 181

Query: 192 PSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEY 251
                  L +R L  DT+D  PLLKE++  K   +I   +  M+  IL +A  +GM++ Y
Sbjct: 182 FLISKDTLSVRMLD-DTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAY 240

Query: 252 YHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQ----VSSIIEKWSMERLQAPPKP 307
           Y YIFT L+     ++      VN+ GF I N  +        S+ + W  E     P  
Sbjct: 241 YTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQ-ENCDHVPFT 299

Query: 308 DSGLLDGFMTTDAALMYDAVHVVSVAVQQF---PQMTVSSLQCNRHKPWRFGTRFMSLIK 364
              L        +AL++DAV+ V  AVQ+     ++ V  L C   + W+ GT  M+ ++
Sbjct: 300 GPAL-------SSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLR 352

Query: 365 EAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANI 424
               EGLTG I FN + G R+++ L ++     G  +IG W  A GL+M        +NI
Sbjct: 353 MVELEGLTGHIEFN-SKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYA--SNI 409

Query: 425 TDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVE 484
           +D+L N +L+VTTILE PY++ K + + + GNDR+EG+C+D+L+EL+ IL F Y+IRLV 
Sbjct: 410 SDTLFNTTLVVTTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVG 469

Query: 485 DGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRK 544
           DG YG  + ANG W GMV ELI  KADLAVA L IT  REKVIDFSKPFMTLGISILYR 
Sbjct: 470 DGVYGVPE-ANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRV 528

Query: 545 PNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDS-DVVE 603
             G  PG FSFL+P SP +W+++LLAYL VSCVLF++AR +PYEWY+PHPC     +++ 
Sbjct: 529 HMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLV 588

Query: 604 NNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVER 663
           N ++L NS WF VG  MQQGS + P+ALSTR V G+WW FTLIIISSYTANLAAFLTV+R
Sbjct: 589 NQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQR 648

Query: 664 MESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEE 723
           M+ PI+S DDLA QT IEYG +  G++MTFF+ S+  TY +MW +M S++ SV VKS EE
Sbjct: 649 MDVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEE 708

Query: 724 GIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAIL 783
           GI RVL S+YAFL+EST  E+  QRNCNLTQIGGL+D+KGYG+G P+GS +RD+  +AIL
Sbjct: 709 GIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAIL 768

Query: 784 QLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFL 843
           QLQE  +L ++K KWW G  CP+EE   A  LG++NIGGIF+VL  GL++++F+A+ EFL
Sbjct: 769 QLQENNRLEILKRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFL 828

Query: 844 YKSKKNAQLEKRSFCSAMVEELRMSLKCQ-------RRLKHKPQAPVIVKTEEVINMHTF 896
           + + ++++  + S C  MV ELR  + CQ       RR    P  P I +        T 
Sbjct: 829 W-TLRHSEATEVSVCQEMVTELRSIILCQDSIHPRRRRAAVPPPRPPIPEERRPRGTATL 887

Query: 897 NDRRLPG 903
           ++ +L G
Sbjct: 888 SNGKLCG 894


>gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [Homo
           sapiens]
          Length = 906

 Score =  623 bits (1607), Expect = e-178
 Identities = 347/848 (40%), Positives = 512/848 (60%), Gaps = 54/848 (6%)

Query: 36  LRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKA 95
           ++ GG+F   +S     E  AFRFA++ +     LLP   +      +N+ DSFE + + 
Sbjct: 25  IQIGGLFPNQQS----QEHAAFRFALSQLTEPPKLLPQIDI------VNISDSFEMTYRF 74

Query: 96  CDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSS 155
           C Q S GV AIFG     + N + S C AL V  I   +     D  + F + L P+   
Sbjct: 75  CSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFP---VDTSNQFVLQLRPE--- 128

Query: 156 LSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDA-KPL 214
           L  A++ ++  +KW+    +YD   GL  LQ+++   +  N ++    +   T++  + L
Sbjct: 129 LQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTTTEEGYRML 188

Query: 215 LKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGV 274
            +++++ KE  V+ DC  E    IL Q + +      YHYI   L    +D+  ++ SG 
Sbjct: 189 FQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDLNKFKESGA 248

Query: 275 NMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAV 334
           N+TGF+++N  +T  + I+++W     +   + D           +AL YD V V++ A 
Sbjct: 249 NVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKR----PKYTSALTYDGVKVMAEAF 304

Query: 335 QQFPQMTVSSLQ--------CNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTD 386
           Q   +  +   +         N   PW  G      +++  +EGLTG + FN+  G RT+
Sbjct: 305 QSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNE-KGRRTN 363

Query: 387 FDLDVISLKEEGLEKIGTWD------PASGLNMTESQKGKPANITDSLSNRSLIVTTILE 440
           + L VI +K +G+ KIG W+      PA+    T++Q G       S+ NR+ IVTTILE
Sbjct: 364 YTLHVIEMKHDGIRKIGYWNEDDKFVPAA----TDAQAGGD---NSSVQNRTYIVTTILE 416

Query: 441 EPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNG 500
           +PYV+ KK+     GNDR+EGYC++L  E++  +G++Y + +V DGKYGA+D     WNG
Sbjct: 417 DPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNG 476

Query: 501 MVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLS 560
           MV EL+  +AD+AVAPL IT VRE+VIDFSKPFM+LGISI+ +KP  + PGVFSFL+PL+
Sbjct: 477 MVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLA 536

Query: 561 PDIWMYILLAYLGVSCVLFVIARFSPYEWYN---PHPCNPDSDVVENNFTLLNSFWFGVG 617
            +IWM I+ AY+GVS VLF+++RFSPYEW++       +  +    N F + NS WF +G
Sbjct: 537 YEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLG 596

Query: 618 ALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQ 677
           A MQQG ++ P++LS RIVGG+WWFFTLIIISSYTANLAAFLTVERM SPI+SA+DLAKQ
Sbjct: 597 AFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ 656

Query: 678 TKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTS--DYAF 735
           T+I YG +E G+T  FF++SKI+ ++KMW +M S   SV V++ EEG+ RV  S   YA+
Sbjct: 657 TEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAY 716

Query: 736 LMESTTIEFVTQRN-CNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMM 794
           L+EST  E++ QR  C+  ++GG +DSKGYG+ TP GS  R  + +A+L+L E+G L  +
Sbjct: 717 LLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRGPVNLAVLKLSEQGVLDKL 776

Query: 795 KEKWWRGNG-CPEEES---KEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNA 850
           K KWW   G C  ++S    + SAL + N+ G+F +L  GL L++ VA+ EF YKS+  +
Sbjct: 777 KSKWWYDKGECGSKDSGSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSES 836

Query: 851 QLEKRSFC 858
           +   + FC
Sbjct: 837 K-RMKGFC 843


>gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [Homo
           sapiens]
          Length = 906

 Score =  622 bits (1604), Expect = e-178
 Identities = 346/848 (40%), Positives = 511/848 (60%), Gaps = 54/848 (6%)

Query: 36  LRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKA 95
           ++ GG+F   +S     E  AFRFA++ +     LLP   +      +N+ DSFE + + 
Sbjct: 25  IQIGGLFPNQQS----QEHAAFRFALSQLTEPPKLLPQIDI------VNISDSFEMTYRF 74

Query: 96  CDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSS 155
           C Q S GV AIFG     + N + S C AL V  I   +     D  + F + L P+   
Sbjct: 75  CSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFP---VDTSNQFVLQLRPE--- 128

Query: 156 LSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDA-KPL 214
           L  A++ ++  +KW+    +YD   GL  LQ+++   +  N ++    +   T++  + L
Sbjct: 129 LQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTTTEEGYRML 188

Query: 215 LKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGV 274
            +++++ KE  V+ DC  E    IL Q + +      YHYI   L    +D+  ++ SG 
Sbjct: 189 FQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDLNKFKESGA 248

Query: 275 NMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAV 334
           N+TGF+++N  +T  + I+++W     +   + D           +AL YD V V++ A 
Sbjct: 249 NVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKR----PKYTSALTYDGVKVMAEAF 304

Query: 335 QQFPQMTVSSLQ--------CNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTD 386
           Q   +  +   +         N   PW  G      +++  +EGLTG + FN+  G RT+
Sbjct: 305 QSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNE-KGRRTN 363

Query: 387 FDLDVISLKEEGLEKIGTWD------PASGLNMTESQKGKPANITDSLSNRSLIVTTILE 440
           + L VI +K +G+ KIG W+      PA+    T++Q G       S+ NR+ IVTTILE
Sbjct: 364 YTLHVIEMKHDGIRKIGYWNEDDKFVPAA----TDAQAGGD---NSSVQNRTYIVTTILE 416

Query: 441 EPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNG 500
           +PYV+ KK+     GNDR+EGYC++L  E++  +G++Y + +V DGKYGA+D     WNG
Sbjct: 417 DPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNG 476

Query: 501 MVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLS 560
           MV EL+  +AD+AVAPL IT VRE+VIDFSKPFM+LGISI+ +KP  + PGVFSFL+PL+
Sbjct: 477 MVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLA 536

Query: 561 PDIWMYILLAYLGVSCVLFVIARFSPYEWYN---PHPCNPDSDVVENNFTLLNSFWFGVG 617
            +IWM I+ AY+GVS VLF+++RFSPYEW++       +  +    N F + NS WF +G
Sbjct: 537 YEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLG 596

Query: 618 ALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQ 677
           A MQQG ++ P++LS RIVGG+WWFFTLIIISSYTANLAAFLTVERM SPI+SA+DLAKQ
Sbjct: 597 AFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ 656

Query: 678 TKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTS--DYAF 735
           T+I YG +E G+T  FF++SKI+ ++KMW +M S   SV V++ EEG+ RV  S   YA+
Sbjct: 657 TEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAY 716

Query: 736 LMESTTIEFVTQRN-CNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMM 794
           L+EST  E++ QR  C+  ++GG +DSKGYG+ TP GS  R+ + +A+L+L E+G L  +
Sbjct: 717 LLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKL 776

Query: 795 KEKWWRGNG-CPE---EESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNA 850
           K KWW   G C     +   + SAL + N+ G+F +L  GL L++ VA+ EF YKS+  +
Sbjct: 777 KNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSES 836

Query: 851 QLEKRSFC 858
           +   + FC
Sbjct: 837 K-RMKGFC 843


>gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1
           precursor [Homo sapiens]
          Length = 883

 Score =  615 bits (1585), Expect = e-176
 Identities = 346/862 (40%), Positives = 511/862 (59%), Gaps = 50/862 (5%)

Query: 19  LLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTY 78
           LL  +LW      +++ ++ GG+F      P GA++    F V  +  + +      LT 
Sbjct: 10  LLSPVLWGLIFGVSSNSIQIGGLF------PRGADQEYSAFRVGMVQFSTS---EFRLTP 60

Query: 79  DTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQV 138
               + + +SF  +   C Q S GV AIFG     S N + S C  L V  I   +    
Sbjct: 61  HIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFP--- 117

Query: 139 SDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLR 198
           +D    F + + PD   L  A+L L+++++W     +YD   GL  LQ ++ + +    +
Sbjct: 118 TDGTHPFVIQMRPD---LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQ 174

Query: 199 ---LKIRQLPADTKDA--KPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYH 253
              + +  +  D KD   + L ++++  KE  VI DC  +    I+ Q + +G   + YH
Sbjct: 175 VTAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYH 234

Query: 254 YIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWS-MERLQAPPKPDSGLL 312
           YI   L     D+   ++ G N++GF+I++ +++ VS  IE+WS +E  + P     G  
Sbjct: 235 YIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYP-----GAH 289

Query: 313 DGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQ--------CNRHKPWRFGTRFMSLIK 364
              +   +AL YDAV V++ A +   +  +   +         N   PW  G      +K
Sbjct: 290 TTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALK 349

Query: 365 EAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGL--NMTESQKGKPA 422
           +   EGL+G I F++ NG R ++ ++++ LK  G  KIG W     +   +TE   G   
Sbjct: 350 QVQVEGLSGNIKFDQ-NGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSG--- 405

Query: 423 NITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRL 482
           N T  L N++++VTTILE PYV+ KK+ + L GN+R+EGYC+DL  E++   GF Y++ +
Sbjct: 406 NDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTI 465

Query: 483 VEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILY 542
           V DGKYGA+D     WNGMV EL+  KAD+A+APL IT VRE+VIDFSKPFM+LGISI+ 
Sbjct: 466 VGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMI 525

Query: 543 RKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPH---PCNPDS 599
           +KP  + PGVFSFL+PL+ +IWM I+ AY+GVS VLF+++RFSPYEW+           S
Sbjct: 526 KKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQS 585

Query: 600 DVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFL 659
               N F + NS WF +GA M+QG ++ P++LS RIVGG+WWFFTLIIISSYTANLAAFL
Sbjct: 586 SESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFL 645

Query: 660 TVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVK 719
           TVERM SPI+SA+DL+KQT+I YG ++ G+T  FF++SKI+ +DKMW +M S   SV V+
Sbjct: 646 TVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVR 705

Query: 720 SNEEGIQRVLTS--DYAFLMESTTIEFVTQRN-CNLTQIGGLIDSKGYGVGTPMGSPYRD 776
           +  EG+ RV  S   YA+L+EST  E++ QR  C+  ++GG +DSKGYG+ TP GS  R 
Sbjct: 706 TTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRT 765

Query: 777 KITIAILQLQEEGKLHMMKEKWWRGNG-CPEEES---KEASALGVQNIGGIFIVLAAGLV 832
            + +A+L+L E+G L  +K KWW   G C  ++S   ++ SAL + N+ G+F +L  GL 
Sbjct: 766 PVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLG 825

Query: 833 LSVFVAVGEFLYKSKKNAQLEK 854
           L++ VA+ EF YKS+  A+  K
Sbjct: 826 LAMLVALIEFCYKSRAEAKRMK 847


>gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2
           precursor [Homo sapiens]
          Length = 883

 Score =  614 bits (1583), Expect = e-175
 Identities = 345/862 (40%), Positives = 510/862 (59%), Gaps = 50/862 (5%)

Query: 19  LLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTY 78
           LL  +LW      +++ ++ GG+F      P GA++    F V  +  + +      LT 
Sbjct: 10  LLSPVLWGLIFGVSSNSIQIGGLF------PRGADQEYSAFRVGMVQFSTS---EFRLTP 60

Query: 79  DTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQV 138
               + + +SF  +   C Q S GV AIFG     S N + S C  L V  I   +    
Sbjct: 61  HIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFP--- 117

Query: 139 SDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLR 198
           +D    F + + PD   L  A+L L+++++W     +YD   GL  LQ ++ + +    +
Sbjct: 118 TDGTHPFVIQMRPD---LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQ 174

Query: 199 ---LKIRQLPADTKDA--KPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYH 253
              + +  +  D KD   + L ++++  KE  VI DC  +    I+ Q + +G   + YH
Sbjct: 175 VTAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYH 234

Query: 254 YIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWS-MERLQAPPKPDSGLL 312
           YI   L     D+   ++ G N++GF+I++ +++ VS  IE+WS +E  + P     G  
Sbjct: 235 YIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYP-----GAH 289

Query: 313 DGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQ--------CNRHKPWRFGTRFMSLIK 364
              +   +AL YDAV V++ A +   +  +   +         N   PW  G      +K
Sbjct: 290 TTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALK 349

Query: 365 EAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGL--NMTESQKGKPA 422
           +   EGL+G I F++ NG R ++ ++++ LK  G  KIG W     +   +TE   G   
Sbjct: 350 QVQVEGLSGNIKFDQ-NGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSG--- 405

Query: 423 NITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRL 482
           N T  L N++++VTTILE PYV+ KK+ + L GN+R+EGYC+DL  E++   GF Y++ +
Sbjct: 406 NDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTI 465

Query: 483 VEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILY 542
           V DGKYGA+D     WNGMV EL+  KAD+A+APL IT VRE+VIDFSKPFM+LGISI+ 
Sbjct: 466 VGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMI 525

Query: 543 RKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPH---PCNPDS 599
           +KP  + PGVFSFL+PL+ +IWM I+ AY+GVS VLF+++RFSPYEW+           S
Sbjct: 526 KKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQS 585

Query: 600 DVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFL 659
               N F + NS WF +GA M+QG ++ P++LS RIVGG+WWFFTLIIISSYTANLAAFL
Sbjct: 586 SESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFL 645

Query: 660 TVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVK 719
           TVERM SPI+SA+DL+KQT+I YG ++ G+T  FF++SKI+ +DKMW +M S   SV V+
Sbjct: 646 TVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVR 705

Query: 720 SNEEGIQRVLTS--DYAFLMESTTIEFVTQRN-CNLTQIGGLIDSKGYGVGTPMGSPYRD 776
           +  EG+ RV  S   YA+L+EST  E++ QR  C+  ++GG +DSKGYG+ TP GS  R+
Sbjct: 706 TTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRN 765

Query: 777 KITIAILQLQEEGKLHMMKEKWWRGNG-CPE---EESKEASALGVQNIGGIFIVLAAGLV 832
            + +A+L+L E+G L  +K KWW   G C     +  ++ SAL + N+ G+F +L  GL 
Sbjct: 766 AVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLG 825

Query: 833 LSVFVAVGEFLYKSKKNAQLEK 854
           L++ VA+ EF YKS+  A+  K
Sbjct: 826 LAMLVALIEFCYKSRAEAKRMK 847


>gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1
           precursor [Homo sapiens]
          Length = 894

 Score =  611 bits (1576), Expect = e-175
 Identities = 359/875 (41%), Positives = 517/875 (59%), Gaps = 51/875 (5%)

Query: 8   LSNPVFRRTVKLLLCLLWIGYSQGT-THVLRFGGIFEYVESGPMGAEELAFRFAVNTINR 66
           +   V R    L+L LL  G+S G   + +  GG+F          E  AFRFAV   N 
Sbjct: 7   MGQSVLRAVFFLVLGLL--GHSHGGFPNTISIGGLF----MRNTVQEHSAFRFAVQLYNT 60

Query: 67  NRTLLPNTT-----LTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSI 121
           N+    NTT     L Y    ++  +SF  +   C Q S GV AIFG     S N + S 
Sbjct: 61  NQ----NTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSF 116

Query: 122 CNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTG 181
           C AL    +   +    +D    F + + P   +L  AIL L+  +KW+    +YD   G
Sbjct: 117 CGALHTSFVTPSFP---TDADVQFVIQMRP---ALKGAILSLLGHYKWEKFVYLYDTERG 170

Query: 182 LIRLQELIKAPSRYNLRLKIRQLP--ADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGIL 239
              LQ +++A  + N ++  R +    D ++ + +++EM R +E   + DC  E    IL
Sbjct: 171 FSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTIL 230

Query: 240 KQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSME 299
           +Q + +G  +  YHY+   L    + +E   + G N+TGF+I+N EN  V   I++W   
Sbjct: 231 EQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWV-- 288

Query: 300 RLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTV------SSLQC--NRHK 351
           RL     P++   +  +   +AL +DA+ V++ A +   +  V      S+  C  N   
Sbjct: 289 RLDEREFPEAK--NAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAV 346

Query: 352 PWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGL 411
           PW  G      +K    +G+TG I F+ T G RT++ +DV  +K  G  K G W+     
Sbjct: 347 PWSQGIDIERALKMVQVQGMTGNIQFD-TYGRRTNYTIDVYEMKVSGSRKAGYWNEYERF 405

Query: 412 NMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELS 471
                Q+   +N + S  NR+++VTTILE PYV++KK+ + L GN+R+EGYC+DL  E++
Sbjct: 406 VPFSDQQ--ISNDSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIA 463

Query: 472 TILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSK 531
             +   Y++ +V DGKYGA+D     WNGMV EL+  +AD+AVAPL IT VRE+VIDFSK
Sbjct: 464 KHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSK 523

Query: 532 PFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWY- 590
           PFM+LGISI+ +KP  + PGVFSFL+PL+ +IWM I+ AY+GVS VLF+++RFSPYEW+ 
Sbjct: 524 PFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHL 583

Query: 591 ---NPHPCNPDSDV-VENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLI 646
              N  P +P S     N F + NS WF +GA MQQG ++ P++LS RIVGG+WWFFTLI
Sbjct: 584 EDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLI 643

Query: 647 IISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMW 706
           IISSYTANLAAFLTVERM SPI+SA+DLAKQT+I YG ++ G+T  FF++SKI+ Y+KMW
Sbjct: 644 IISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMW 703

Query: 707 AFMSSRRQSVLVKSNEEGIQRVLTS--DYAFLMESTTIEFVTQRN-CNLTQIGGLIDSKG 763
           ++M S   SV  K+  +G+ RV  S   +AFL+EST  E++ QR  C+  ++GG +DSKG
Sbjct: 704 SYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKG 763

Query: 764 YGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG-CPEEES---KEASALGVQN 819
           YGV TP GS     + +A+L+L E+G L  +K KWW   G C  ++S    + SAL + N
Sbjct: 764 YGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSN 823

Query: 820 IGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEK 854
           + G+F +L  GL L++ VA+ EF YKS+  ++  K
Sbjct: 824 VAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMK 858


>gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2
           precursor [Homo sapiens]
          Length = 894

 Score =  611 bits (1575), Expect = e-174
 Identities = 358/875 (40%), Positives = 516/875 (58%), Gaps = 51/875 (5%)

Query: 8   LSNPVFRRTVKLLLCLLWIGYSQGT-THVLRFGGIFEYVESGPMGAEELAFRFAVNTINR 66
           +   V R    L+L LL  G+S G   + +  GG+F          E  AFRFAV   N 
Sbjct: 7   MGQSVLRAVFFLVLGLL--GHSHGGFPNTISIGGLF----MRNTVQEHSAFRFAVQLYNT 60

Query: 67  NRTLLPNTT-----LTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSI 121
           N+    NTT     L Y    ++  +SF  +   C Q S GV AIFG     S N + S 
Sbjct: 61  NQ----NTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSF 116

Query: 122 CNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTG 181
           C AL    +   +    +D    F + + P   +L  AIL L+  +KW+    +YD   G
Sbjct: 117 CGALHTSFVTPSFP---TDADVQFVIQMRP---ALKGAILSLLGHYKWEKFVYLYDTERG 170

Query: 182 LIRLQELIKAPSRYNLRLKIRQLP--ADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGIL 239
              LQ +++A  + N ++  R +    D ++ + +++EM R +E   + DC  E    IL
Sbjct: 171 FSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTIL 230

Query: 240 KQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSME 299
           +Q + +G  +  YHY+   L    + +E   + G N+TGF+I+N EN  V   I++W   
Sbjct: 231 EQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWV-- 288

Query: 300 RLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTV------SSLQC--NRHK 351
           RL     P++   +  +   +AL +DA+ V++ A +   +  V      S+  C  N   
Sbjct: 289 RLDEREFPEAK--NAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAV 346

Query: 352 PWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGL 411
           PW  G      +K    +G+TG I F+ T G RT++ +DV  +K  G  K G W+     
Sbjct: 347 PWSQGIDIERALKMVQVQGMTGNIQFD-TYGRRTNYTIDVYEMKVSGSRKAGYWNEYERF 405

Query: 412 NMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELS 471
                Q+   +N + S  NR+++VTTILE PYV++KK+ + L GN+R+EGYC+DL  E++
Sbjct: 406 VPFSDQQ--ISNDSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIA 463

Query: 472 TILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSK 531
             +   Y++ +V DGKYGA+D     WNGMV EL+  +AD+AVAPL IT VRE+VIDFSK
Sbjct: 464 KHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSK 523

Query: 532 PFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWY- 590
           PFM+LGISI+ +KP  + PGVFSFL+PL+ +IWM I+ AY+GVS VLF+++RFSPYEW+ 
Sbjct: 524 PFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHL 583

Query: 591 ---NPHPCNPDSDV-VENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLI 646
              N  P +P S     N F + NS WF +GA MQQG ++ P++LS RIVGG+WWFFTLI
Sbjct: 584 EDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLI 643

Query: 647 IISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMW 706
           IISSYTANLAAFLTVERM SPI+SA+DLAKQT+I YG ++ G+T  FF++SKI+ Y+KMW
Sbjct: 644 IISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMW 703

Query: 707 AFMSSRRQSVLVKSNEEGIQRVLTS--DYAFLMESTTIEFVTQRN-CNLTQIGGLIDSKG 763
           ++M S   SV  K+  +G+ RV  S   +AFL+EST  E++ QR  C+  ++GG +DSKG
Sbjct: 704 SYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKG 763

Query: 764 YGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG-CPE---EESKEASALGVQN 819
           YGV TP GS   + + +A+L+L E+G L  +K KWW   G C     +   + SAL + N
Sbjct: 764 YGVATPKGSALGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSN 823

Query: 820 IGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEK 854
           + G+F +L  GL L++ VA+ EF YKS+  ++  K
Sbjct: 824 VAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMK 858


>gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [Homo
           sapiens]
          Length = 836

 Score =  609 bits (1571), Expect = e-174
 Identities = 334/805 (41%), Positives = 487/805 (60%), Gaps = 41/805 (5%)

Query: 76  LTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWK 135
           LT     + + +SF  +   C Q S GV AIFG     S N + S C  L V  I   + 
Sbjct: 11  LTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFP 70

Query: 136 HQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRY 195
              +D    F + + PD   L  A+L L+++++W     +YD   GL  LQ ++ + +  
Sbjct: 71  ---TDGTHPFVIQMRPD---LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEK 124

Query: 196 NLR---LKIRQLPADTKDA--KPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTE 250
             +   + +  +  D KD   + L ++++  KE  VI DC  +    I+ Q + +G   +
Sbjct: 125 KWQVTAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVK 184

Query: 251 YYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWS-MERLQAPPKPDS 309
            YHYI   L     D+   ++ G N++GF+I++ +++ VS  IE+WS +E  + P     
Sbjct: 185 GYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYP----- 239

Query: 310 GLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQ--------CNRHKPWRFGTRFMS 361
           G     +   +AL YDAV V++ A +   +  +   +         N   PW  G     
Sbjct: 240 GAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIER 299

Query: 362 LIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGL--NMTESQKG 419
            +K+   EGL+G I F++ NG R ++ ++++ LK  G  KIG W     +   +TE   G
Sbjct: 300 ALKQVQVEGLSGNIKFDQ-NGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSG 358

Query: 420 KPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYE 479
              N T  L N++++VTTILE PYV+ KK+ + L GN+R+EGYC+DL  E++   GF Y+
Sbjct: 359 ---NDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYK 415

Query: 480 IRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGIS 539
           + +V DGKYGA+D     WNGMV EL+  KAD+A+APL IT VRE+VIDFSKPFM+LGIS
Sbjct: 416 LTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGIS 475

Query: 540 ILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPH---PCN 596
           I+ +KP  + PGVFSFL+PL+ +IWM I+ AY+GVS VLF+++RFSPYEW+         
Sbjct: 476 IMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRE 535

Query: 597 PDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLA 656
             S    N F + NS WF +GA M+QG ++ P++LS RIVGG+WWFFTLIIISSYTANLA
Sbjct: 536 TQSSESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLA 595

Query: 657 AFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSV 716
           AFLTVERM SPI+SA+DL+KQT+I YG ++ G+T  FF++SKI+ +DKMW +M S   SV
Sbjct: 596 AFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSV 655

Query: 717 LVKSNEEGIQRVLTS--DYAFLMESTTIEFVTQRN-CNLTQIGGLIDSKGYGVGTPMGSP 773
            V++  EG+ RV  S   YA+L+EST  E++ QR  C+  ++GG +DSKGYG+ TP GS 
Sbjct: 656 FVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSS 715

Query: 774 YRDKITIAILQLQEEGKLHMMKEKWWRGNG-CPEEES---KEASALGVQNIGGIFIVLAA 829
            R  + +A+L+L E+G L  +K KWW   G C  ++S   ++ SAL + N+ G+F +L  
Sbjct: 716 LRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVG 775

Query: 830 GLVLSVFVAVGEFLYKSKKNAQLEK 854
           GL L++ VA+ EF YKS+  A+  K
Sbjct: 776 GLGLAMLVALIEFCYKSRAEAKRMK 800


>gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1
           precursor [Homo sapiens]
          Length = 902

 Score =  593 bits (1529), Expect = e-169
 Identities = 345/883 (39%), Positives = 507/883 (57%), Gaps = 47/883 (5%)

Query: 12  VFRRTVKLLLCLLWIGYSQGT-THVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTL 70
           +  R + LL    W G + G     ++ GG+F          E  AFR A+   N +   
Sbjct: 3   IISRQIVLLFSGFW-GLAMGAFPSSVQIGGLF----IRNTDQEYTAFRLAIFLHNTS--- 54

Query: 71  LPNTT-----LTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNAL 125
            PN +     L      I   +SF  +   C Q S GV AIFG     S + + S C+AL
Sbjct: 55  -PNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSAL 113

Query: 126 GVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRL 185
              HI        ++ +  F + L P   SL  A+L L+  ++W     +YD   G   L
Sbjct: 114 ---HISLITPSFPTEGESQFVLQLRP---SLRGALLSLLDHYEWNCFVFLYDTDRGYSIL 167

Query: 186 QELIKAPSRYNLRLK-IRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALA 244
           Q +++   +    +  I     +    + LL+E+ R +E   + DC  E    IL+Q ++
Sbjct: 168 QAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVS 227

Query: 245 MGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAP 304
           +G   + YHYI   L    + +E + + G N+TGF++++     V  ++++W  ++L   
Sbjct: 228 VGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRW--KKLDQR 285

Query: 305 PKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQ--------CNRHKPWRFG 356
             P S     + +   AL YD V V++   +   +  +   +         N   PW  G
Sbjct: 286 EYPGSETPPKYTS---ALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQG 342

Query: 357 TRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTES 416
                 +K+   +GLTG + F+   G R ++ +DV  LK  G  K+G W+    L + + 
Sbjct: 343 IDMERTLKQVRIQGLTGNVQFDHY-GRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQD 401

Query: 417 QKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGF 476
                 N T ++ NR+++VTTI+E PYV++KK+ +   GND++EGYC+DL  E++  +G 
Sbjct: 402 VPTL-GNDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGI 460

Query: 477 TYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTL 536
            Y+I +V DGKYGA+D     WNGMV EL+  KA++A+APL IT VRE+VIDFSKPFM+L
Sbjct: 461 KYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSL 520

Query: 537 GISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHP-- 594
           GISI+ +KP  + PGVFSFL+PL+ +IWM I+ AY+GVS VLF+++RFSPYEW+   P  
Sbjct: 521 GISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPED 580

Query: 595 -CNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTA 653
                SD   N F + NS WF +GA MQQG ++ P++LS RIVGG+WWFFTLIIISSYTA
Sbjct: 581 GKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTA 640

Query: 654 NLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRR 713
           NLAAFLTVERM SPI+SA+DLAKQT+I YG ++ G+T  FF++SKI+ Y+KMW +M S  
Sbjct: 641 NLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAE 700

Query: 714 QSVLVKSNEEGIQRVLTS--DYAFLMESTTIEFVTQRN-CNLTQIGGLIDSKGYGVGTPM 770
            SV  ++  EG+ RV  S   +AFL+EST  E++ QR  C+  ++GG +DSKGYGV TP 
Sbjct: 701 PSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPK 760

Query: 771 GSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG-CPEEES---KEASALGVQNIGGIFIV 826
           GS     + +A+L+L E G L  +K KWW   G C  ++S    + SAL + N+ G+F +
Sbjct: 761 GSSLGTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYI 820

Query: 827 LAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSL 869
           L  GL L++ VA+ EF YKS+  A+  K +F  A+  + R+S+
Sbjct: 821 LVGGLGLAMLVALIEFCYKSRAEAKRMKLTFSEAIRNKARLSI 863


>gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2
           precursor [Homo sapiens]
          Length = 884

 Score =  586 bits (1511), Expect = e-167
 Identities = 340/868 (39%), Positives = 498/868 (57%), Gaps = 47/868 (5%)

Query: 12  VFRRTVKLLLCLLWIGYSQGT-THVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTL 70
           +  R + LL    W G + G     ++ GG+F          E  AFR A+   N +   
Sbjct: 3   IISRQIVLLFSGFW-GLAMGAFPSSVQIGGLF----IRNTDQEYTAFRLAIFLHNTS--- 54

Query: 71  LPNTT-----LTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNAL 125
            PN +     L      I   +SF  +   C Q S GV AIFG     S + + S C+AL
Sbjct: 55  -PNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSAL 113

Query: 126 GVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRL 185
              HI        ++ +  F + L P   SL  A+L L+  ++W     +YD   G   L
Sbjct: 114 ---HISLITPSFPTEGESQFVLQLRP---SLRGALLSLLDHYEWNCFVFLYDTDRGYSIL 167

Query: 186 QELIKAPSRYNLRLK-IRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALA 244
           Q +++   +    +  I     +    + LL+E+ R +E   + DC  E    IL+Q ++
Sbjct: 168 QAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVS 227

Query: 245 MGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAP 304
           +G   + YHYI   L    + +E + + G N+TGF++++     V  ++++W  ++L   
Sbjct: 228 VGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRW--KKLDQR 285

Query: 305 PKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQ--------CNRHKPWRFG 356
             P S     + +   AL YD V V++   +   +  +   +         N   PW  G
Sbjct: 286 EYPGSETPPKYTS---ALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQG 342

Query: 357 TRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTES 416
                 +K+   +GLTG + F+   G R ++ +DV  LK  G  K+G W+    L + + 
Sbjct: 343 IDMERTLKQVRIQGLTGNVQFDHY-GRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQD 401

Query: 417 QKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGF 476
                 N T ++ NR+++VTTI+E PYV++KK+ +   GND++EGYC+DL  E++  +G 
Sbjct: 402 VPTL-GNDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGI 460

Query: 477 TYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTL 536
            Y+I +V DGKYGA+D     WNGMV EL+  KA++A+APL IT VRE+VIDFSKPFM+L
Sbjct: 461 KYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSL 520

Query: 537 GISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHP-- 594
           GISI+ +KP  + PGVFSFL+PL+ +IWM I+ AY+GVS VLF+++RFSPYEW+   P  
Sbjct: 521 GISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPED 580

Query: 595 -CNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTA 653
                SD   N F + NS WF +GA MQQG ++ P++LS RIVGG+WWFFTLIIISSYTA
Sbjct: 581 GKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTA 640

Query: 654 NLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRR 713
           NLAAFLTVERM SPI+SA+DLAKQT+I YG ++ G+T  FF++SKI+ Y+KMW +M S  
Sbjct: 641 NLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAE 700

Query: 714 QSVLVKSNEEGIQRVLTS--DYAFLMESTTIEFVTQRN-CNLTQIGGLIDSKGYGVGTPM 770
            SV  ++  EG+ RV  S   +AFL+EST  E++ QR  C+  ++GG +DSKGYGV TP 
Sbjct: 701 PSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPK 760

Query: 771 GSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG-CPE---EESKEASALGVQNIGGIFIV 826
           GS   + + +A+L+L E+G L  +K KWW   G C     +   + SAL + N+ G+F +
Sbjct: 761 GSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYI 820

Query: 827 LAAGLVLSVFVAVGEFLYKSKKNAQLEK 854
           L  GL L++ VA+ EF YKS+  A+  K
Sbjct: 821 LVGGLGLAMLVALIEFCYKSRAEAKRMK 848


>gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [Homo
           sapiens]
          Length = 1009

 Score =  362 bits (928), Expect = 1e-99
 Identities = 264/907 (29%), Positives = 447/907 (49%), Gaps = 85/907 (9%)

Query: 35  VLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKK 94
           ++  G IFE   +     ++  F+ AV+ ++ N  +L +  +TY  + I   + F+A ++
Sbjct: 23  IIHIGAIFEENAA----KDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQE 78

Query: 95  ACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFS 154
           ACD ++ G+ A+   +  +SANA+QS+ +A+ +PH+  + ++     + + +++  PD  
Sbjct: 79  ACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQ-RNPGGSPRTACHLNPSPDGE 137

Query: 155 S----------LSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQL 204
           +          L+  +L LV   +W+   + YD    +  LQ  +   SR  L + ++++
Sbjct: 138 AYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKV 197

Query: 205 PADTKDAKPLLKEMKRGKEFH--------VIFDCSHEMAAGILKQALAMGMMTEYYHYIF 256
             +       L    + +E +         I   S + A   + +A+   + ++  H++F
Sbjct: 198 DKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVF 257

Query: 257 TTLDLFALDVEPYRYSGVN-MTGFRIL----------NTENTQVSSIIEKWSMERLQAPP 305
              ++   ++    +S +  MT  R +             N ++SS++            
Sbjct: 258 VNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNNHRISSLL-----------C 306

Query: 306 KPDSGLLDGFMTTDAALMYDAVHVVSVA----VQQFPQMTVSSLQCNRH--KPWRFGTRF 359
            P  G L     ++  L YD+V +++ A    ++     +++SL C R   KPW  G   
Sbjct: 307 DPQEGYLQMLQISNLYL-YDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSM 365

Query: 360 MSLIKEAHWEGLTGRITFNK-TNGLRTDFDLDVISLKE---EGLEKIGTWDPASGLNMTE 415
           +  IK+ H  GLTG + F + ++     F++   +  E   + + K+ TWD   GLN + 
Sbjct: 366 LDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSL 425

Query: 416 SQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILG 475
            ++   +     L   +L V T+LEEP+V+   ++  L    R++G+ ID+L  L+  LG
Sbjct: 426 QERPMGSR----LQGLTLKVVTVLEEPFVMV--AENILGQPKRYKGFSIDVLDALAKALG 479

Query: 476 FTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMT 535
           F YEI    DG+YG Q   N  WNGM+ ELI  +ADLA++ + IT  RE V+DFSK +M 
Sbjct: 480 FKYEIYQAPDGRYGHQLH-NTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMD 538

Query: 536 LGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPC 595
             + IL +KP      +FS   P    +W  I  A   V  ++FV+ R       +    
Sbjct: 539 YSVGILIKKPE-EKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQP 597

Query: 596 NPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANL 655
            P +       TL ++ W   GA +QQG E    +++ RIV G WW FTLI+ SSYTANL
Sbjct: 598 RPSASA-----TLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANL 652

Query: 656 AAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKK------SKISTYDKMWAFM 709
           AAFLTV RM++PI +  DL+KQ ++ YG V D A   +F+        + ST+ ++W  +
Sbjct: 653 AAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTI 712

Query: 710 SSR-RQSVLVKSNEEGIQRVLTSDYAFLMESTTIEF--VTQRNCNLTQIGGLIDSKGYGV 766
           S        V S  EGI++    +YAFL +   +E+  +T  +C++T IG  I SKGYG+
Sbjct: 713 SKNGGADNCVSSPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGI 772

Query: 767 GTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG-CPEEESKEASA----LGVQNIG 821
               GSPYRD  +  IL+LQ+ G L ++K+KWW   G C       A A    L + +  
Sbjct: 773 ALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFA 832

Query: 822 GIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEEL--RMSLKCQRRLKHKP 879
           G+F +LA GL+L+  VA  E  + S +  Q   +      +E++  RM+      + HK 
Sbjct: 833 GVFCILAIGLLLACLVAALELWWNSNRCHQETPKEDKEVNLEQVHRRMNSLMDEDIAHKQ 892

Query: 880 QAPVIVK 886
            +P  ++
Sbjct: 893 ISPASIE 899


>gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens]
          Length = 1007

 Score =  357 bits (916), Expect = 3e-98
 Identities = 258/877 (29%), Positives = 435/877 (49%), Gaps = 80/877 (9%)

Query: 29  SQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDS 88
           S     ++  G IF+  ES     E   FR AV  +N+N  +L    +T+    ++  + 
Sbjct: 20  SANADSIIHIGAIFD--ESAKKDDE--VFRTAVGDLNQNEEILQTEKITFSVTFVDGNNP 75

Query: 89  FEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHI----------QTRWKHQV 138
           F+A ++AC+ ++ G+ A+      +SA ++QS+ +A+ +PH+          ++      
Sbjct: 76  FQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTR 135

Query: 139 SDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLR 198
           S+  D + +S+ P    L   IL +V  + W+   + YD    +  +QE +   S+  + 
Sbjct: 136 SNRNDDYTLSVRPPVY-LHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMD 194

Query: 199 LKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYY------ 252
           + ++++  +       L +  R +E +   D     A  ++  A A   +TE        
Sbjct: 195 VALQKVENNINKMITTLFDTMRIEELNRYRDTLRR-AILVMNPATAKSFITEVVETNLVA 253

Query: 253 ---HYIFTTLDLFALDV-EPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPD 308
              H+I    ++  +DV E  R S   +T  R       Q   + +  S    +   +  
Sbjct: 254 FDCHWIIINEEINDVDVQELVRRSIGRLTIIR-------QTFPVPQNISQRCFRGNHRIS 306

Query: 309 SGLLDGF------MTTDAALMYDAVHVVSVA----VQQFPQMTVSSLQCNRH--KPWRFG 356
           S L D        M      +YD V +++ A    ++     +++SL C R   KPW+ G
Sbjct: 307 STLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGG 366

Query: 357 TRFMSLIKEAHWEGLTGRITFNKTNGL-RTDFDLDVISLKEE---GLEKIGTWDPASGLN 412
              +  IK+    GLTG + F +  G     F++   +  EE   G+ K+G W+P +GLN
Sbjct: 367 RSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLN 426

Query: 413 MTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELST 472
            + + K     + +++    L V T+LEEP+V+   S+  L    +++G+ ID+L  LS 
Sbjct: 427 GSLTDK----KLENNMRGVVLRVVTVLEEPFVMV--SENVLGKPKKYQGFSIDVLDALSN 480

Query: 473 ILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKP 532
            LGF YEI +  D KYG+  + +G WNG+V EL+  +AD+ ++ L IT  RE V+DF+  
Sbjct: 481 YLGFNYEIYVAPDHKYGSPQE-DGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTR 539

Query: 533 FMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNP 592
           +M   + +L R+   T   +F+ L P    +W  I    L V  +++++       W NP
Sbjct: 540 YMDYSVGVLLRRAEKT-VDMFACLAPFDLSLWACIAGTVLLVGLLVYLL------NWLNP 592

Query: 593 HPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYT 652
                 S     + TL NS WF  G+ +QQG E+    L+TR++ G WW F LI+ISSYT
Sbjct: 593 PRLQMGS---MTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYT 649

Query: 653 ANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKI------STYDKMW 706
           ANLAAFLT+ R+ES I S  DL+KQT+I YG V D A     +   +      S Y +MW
Sbjct: 650 ANLAAFLTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMW 709

Query: 707 AFMS-SRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFV--TQRNCNLTQIGGLIDSKG 763
             ++ S      V  ++ GIQ+V   +YAF+ ++  +E+V     +C+   IG  +  +G
Sbjct: 710 RMINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRG 769

Query: 764 YGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG-----CPEEESKEASALGVQ 818
           YG+    GSPYRD  +  IL+LQ+ G + ++K KWW  NG        +  ++  AL ++
Sbjct: 770 YGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIK 829

Query: 819 NIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKR 855
           +  G+F +LAAG+VLS F+A+ E  +  +K +++  +
Sbjct: 830 SFAGVFCILAAGIVLSCFIAMLETWWNKRKGSRVPSK 866


>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
          Length = 938

 Score =  258 bits (660), Expect = 1e-68
 Identities = 231/895 (25%), Positives = 410/895 (45%), Gaps = 130/895 (14%)

Query: 54  ELAFRFAVNTINRN----RTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIF-- 107
           E  FR AVN  N+     +  L  T++T+    I +     A     D +S  V AI   
Sbjct: 39  EQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQM-----ALSVCEDLISSQVYAILVS 93

Query: 108 ---GPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSF--YVSLYPDFSSLSRAILD 162
               P+   +   V        +P +    +  +  +K     ++   P +S  S    +
Sbjct: 94  HPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFE 153

Query: 163 LVQFFKWK-TVTVVYDDSTGLI---RLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEM 218
           +++ + W   + +V DD  G     RL+ L++   R +   K+ Q    TK+   LL E 
Sbjct: 154 MMRVYSWNHIILLVSDDHEGRAAQKRLETLLE--ERESKAEKVLQFDPGTKNVTALLMEA 211

Query: 219 KRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTG 278
           K  +   +I   S + AA + + A  + M    Y ++    ++        RY+   + G
Sbjct: 212 KELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISG---NALRYAPDGILG 268

Query: 279 FRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFP 338
            +++N +N                                ++A + DAV VV+ AV +  
Sbjct: 269 LQLINGKN--------------------------------ESAHISDAVGVVAQAVHELL 296

Query: 339 Q---MTVSSLQC-NRHKPWRFGTRFMSLIKEAHW-EGLTGRITFNKTNGLRTDFDLDVIS 393
           +   +T     C      W+ G  F  ++  + + +G+TGR+ FN+ +G R   +  +++
Sbjct: 297 EKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNE-DGDRKFANYSIMN 355

Query: 394 LKEEGLEKIGTWDPASGLNMTESQK------GKPANITDSLSNRSLIVTTILEEPYVLFK 447
           L+   L ++G ++   G ++  + +      G+         +  L + TI +EP+V  K
Sbjct: 356 LQNRKLVQVGIYN---GTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVK 412

Query: 448 --------KSDKPLYG-----------NDRFEG------------YCIDLLRELSTILGF 476
                   K +  + G           ND   G            +CIDLL +L+  + F
Sbjct: 413 PTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNF 472

Query: 477 TYEIRLVEDGKYGAQDDANG----QWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKP 532
           TYE+ LV DGK+G Q+  N     +WNGM+ EL+  +AD+ VAPL I   R + I+FSKP
Sbjct: 473 TYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKP 532

Query: 533 FMTLGISILYRK--PNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWY 590
           F   G++IL +K  P  T   + SF+ P    +W+ + L+   V+ +L+++ RFSP+  +
Sbjct: 533 FKYQGLTILVKKEIPRST---LDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRF 589

Query: 591 NPHPCNPDSDVVENNFTLLNSFWFGVGALMQQG-SELMPKALSTRIVGGIWWFFTLIIIS 649
             +    + D +    TL ++ WF  G L+  G  E  P++ S RI+G +W  F +II++
Sbjct: 590 KVNSEEEEEDAL----TLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVA 645

Query: 650 SYTANLAAFLTVERMESPIDSADDLAKQT---KIEYGAVEDGATMTFFKKS-KISTYDKM 705
           SYTANLAAFL ++R E  I   +D   +    K  Y  V+  +   +F++  ++ST   M
Sbjct: 646 SYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELST---M 702

Query: 706 WAFMSSRRQSVLVKSNEEGIQRVLTSD-YAFLMESTTIEFVTQRNCNLTQIGGLIDSKGY 764
           +  M         +S  E IQ V  +  +AF+ +S  +EF   + C+L   G L    G+
Sbjct: 703 YRHMEKHN----YESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGF 758

Query: 765 GVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIF 824
           G+G    SP++  ++++IL+  E G +  + + W R   C +  S   + L  +N+ G+F
Sbjct: 759 GIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQEC-DSRSNAPATLTFENMAGVF 817

Query: 825 IVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKP 879
           +++A G+V  +F+   E  YK  K+A+ ++     A V   R +L+ ++  + +P
Sbjct: 818 MLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEP 872


>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
          Length = 885

 Score =  257 bits (657), Expect = 3e-68
 Identities = 230/886 (25%), Positives = 405/886 (45%), Gaps = 130/886 (14%)

Query: 54  ELAFRFAVNTINRN----RTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIF-- 107
           E  FR AVN  N+     +  L  T++T+    I +     A     D +S  V AI   
Sbjct: 39  EQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQM-----ALSVCEDLISSQVYAILVS 93

Query: 108 ---GPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSF--YVSLYPDFSSLSRAILD 162
               P+   +   V        +P +    +  +  +K     ++   P +S  S    +
Sbjct: 94  HPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFE 153

Query: 163 LVQFFKWK-TVTVVYDDSTGLI---RLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEM 218
           +++ + W   + +V DD  G     RL+ L++   R +   K+ Q    TK+   LL E 
Sbjct: 154 MMRVYSWNHIILLVSDDHEGRAAQKRLETLLE--ERESKAEKVLQFDPGTKNVTALLMEA 211

Query: 219 KRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTG 278
           K  +   +I   S + AA + + A  + M    Y ++    ++        RY+   + G
Sbjct: 212 KELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISG---NALRYAPDGILG 268

Query: 279 FRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFP 338
            +++N +N                                ++A + DAV VV+ AV +  
Sbjct: 269 LQLINGKN--------------------------------ESAHISDAVGVVAQAVHELL 296

Query: 339 Q---MTVSSLQC-NRHKPWRFGTRFMSLIKEAHW-EGLTGRITFNKTNGLRTDFDLDVIS 393
           +   +T     C      W+ G  F  ++  + + +G+TGR+ FN+ +G R   +  +++
Sbjct: 297 EKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNE-DGDRKFANYSIMN 355

Query: 394 LKEEGLEKIGTWDPASGLNMTESQK------GKPANITDSLSNRSLIVTTILEEPYVLFK 447
           L+   L ++G ++   G ++  + +      G+         +  L + TI +EP+V  K
Sbjct: 356 LQNRKLVQVGIYN---GTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVK 412

Query: 448 --------KSDKPLYG-----------NDRFEG------------YCIDLLRELSTILGF 476
                   K +  + G           ND   G            +CIDLL +L+  + F
Sbjct: 413 PTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNF 472

Query: 477 TYEIRLVEDGKYGAQDDANG----QWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKP 532
           TYE+ LV DGK+G Q+  N     +WNGM+ EL+  +AD+ VAPL I   R + I+FSKP
Sbjct: 473 TYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKP 532

Query: 533 FMTLGISILYRK--PNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWY 590
           F   G++IL +K  P  T   + SF+ P    +W+ + L+   V+ +L+++ RFSP+  +
Sbjct: 533 FKYQGLTILVKKEIPRST---LDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRF 589

Query: 591 NPHPCNPDSDVVENNFTLLNSFWFGVGALMQQG-SELMPKALSTRIVGGIWWFFTLIIIS 649
             +    + D +    TL ++ WF  G L+  G  E  P++ S RI+G +W  F +II++
Sbjct: 590 KVNSEEEEEDAL----TLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVA 645

Query: 650 SYTANLAAFLTVERMESPIDSADDLAKQT---KIEYGAVEDGATMTFFKKS-KISTYDKM 705
           SYTANLAAFL ++R E  I   +D   +    K  Y  V+  +   +F++  ++ST   M
Sbjct: 646 SYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELST---M 702

Query: 706 WAFMSSRRQSVLVKSNEEGIQRVLTSD-YAFLMESTTIEFVTQRNCNLTQIGGLIDSKGY 764
           +  M         +S  E IQ V  +  +AF+ +S  +EF   + C+L   G L    G+
Sbjct: 703 YRHMEKHN----YESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGF 758

Query: 765 GVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIF 824
           G+G    SP++  ++++IL+  E G +  + + W R   C +  S   + L  +N+ G+F
Sbjct: 759 GIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQEC-DSRSNAPATLTFENMAGVF 817

Query: 825 IVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLK 870
           +++A G+V  +F+   E  YK  K+A+ ++     A V   R +L+
Sbjct: 818 MLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQ 863


>gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]
          Length = 901

 Score =  257 bits (657), Expect = 3e-68
 Identities = 230/886 (25%), Positives = 405/886 (45%), Gaps = 130/886 (14%)

Query: 54  ELAFRFAVNTINRN----RTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIF-- 107
           E  FR AVN  N+     +  L  T++T+    I +     A     D +S  V AI   
Sbjct: 39  EQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQM-----ALSVCEDLISSQVYAILVS 93

Query: 108 ---GPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSF--YVSLYPDFSSLSRAILD 162
               P+   +   V        +P +    +  +  +K     ++   P +S  S    +
Sbjct: 94  HPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFE 153

Query: 163 LVQFFKWK-TVTVVYDDSTGLI---RLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEM 218
           +++ + W   + +V DD  G     RL+ L++   R +   K+ Q    TK+   LL E 
Sbjct: 154 MMRVYSWNHIILLVSDDHEGRAAQKRLETLLE--ERESKAEKVLQFDPGTKNVTALLMEA 211

Query: 219 KRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTG 278
           K  +   +I   S + AA + + A  + M    Y ++    ++        RY+   + G
Sbjct: 212 KELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISG---NALRYAPDGILG 268

Query: 279 FRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFP 338
            +++N +N                                ++A + DAV VV+ AV +  
Sbjct: 269 LQLINGKN--------------------------------ESAHISDAVGVVAQAVHELL 296

Query: 339 Q---MTVSSLQC-NRHKPWRFGTRFMSLIKEAHW-EGLTGRITFNKTNGLRTDFDLDVIS 393
           +   +T     C      W+ G  F  ++  + + +G+TGR+ FN+ +G R   +  +++
Sbjct: 297 EKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNE-DGDRKFANYSIMN 355

Query: 394 LKEEGLEKIGTWDPASGLNMTESQK------GKPANITDSLSNRSLIVTTILEEPYVLFK 447
           L+   L ++G ++   G ++  + +      G+         +  L + TI +EP+V  K
Sbjct: 356 LQNRKLVQVGIYN---GTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVK 412

Query: 448 --------KSDKPLYG-----------NDRFEG------------YCIDLLRELSTILGF 476
                   K +  + G           ND   G            +CIDLL +L+  + F
Sbjct: 413 PTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNF 472

Query: 477 TYEIRLVEDGKYGAQDDANG----QWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKP 532
           TYE+ LV DGK+G Q+  N     +WNGM+ EL+  +AD+ VAPL I   R + I+FSKP
Sbjct: 473 TYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKP 532

Query: 533 FMTLGISILYRK--PNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWY 590
           F   G++IL +K  P  T   + SF+ P    +W+ + L+   V+ +L+++ RFSP+  +
Sbjct: 533 FKYQGLTILVKKEIPRST---LDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRF 589

Query: 591 NPHPCNPDSDVVENNFTLLNSFWFGVGALMQQG-SELMPKALSTRIVGGIWWFFTLIIIS 649
             +    + D +    TL ++ WF  G L+  G  E  P++ S RI+G +W  F +II++
Sbjct: 590 KVNSEEEEEDAL----TLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVA 645

Query: 650 SYTANLAAFLTVERMESPIDSADDLAKQT---KIEYGAVEDGATMTFFKKS-KISTYDKM 705
           SYTANLAAFL ++R E  I   +D   +    K  Y  V+  +   +F++  ++ST   M
Sbjct: 646 SYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELST---M 702

Query: 706 WAFMSSRRQSVLVKSNEEGIQRVLTSD-YAFLMESTTIEFVTQRNCNLTQIGGLIDSKGY 764
           +  M         +S  E IQ V  +  +AF+ +S  +EF   + C+L   G L    G+
Sbjct: 703 YRHMEKHN----YESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGF 758

Query: 765 GVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIF 824
           G+G    SP++  ++++IL+  E G +  + + W R   C +  S   + L  +N+ G+F
Sbjct: 759 GIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQEC-DSRSNAPATLTFENMAGVF 817

Query: 825 IVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLK 870
           +++A G+V  +F+   E  YK  K+A+ ++     A V   R +L+
Sbjct: 818 MLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQ 863


>gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor
           [Homo sapiens]
          Length = 1484

 Score =  192 bits (488), Expect = 1e-48
 Identities = 142/494 (28%), Positives = 241/494 (48%), Gaps = 64/494 (12%)

Query: 395 KEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLF-------- 446
           KE   E++G W   S L M      +    T+   +  L + T+ E P+V+         
Sbjct: 369 KERKWERVGKWKDKS-LQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVESVDPLSG 427

Query: 447 -----------------KKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYG 489
                            K  ++P Y     +G+CID+L+++S  + FTY++ LV +GK+G
Sbjct: 428 TCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHG 487

Query: 490 AQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGT- 548
            +   NG WNGM+ E++  +A +AV  L I   R +V+DFS PF+  GIS++  + NGT 
Sbjct: 488 KK--INGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTV 545

Query: 549 NPGVFSFLNPLSPDIWMYILLAYLGVSCV-LFVIARFSPYEWYNPHPCNPDS-DVVENNF 606
           +P   +FL P S D+W+ + +  L VS V +FV   FSP  +   + C  D  +    +F
Sbjct: 546 SPS--AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGY---NRCLADGREPGGPSF 600

Query: 607 TLLNSFWFGVGALMQQGSELM-PKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERME 665
           T+  + W   G +      +  PK  +++I+  +W FF +I ++SYTANLAAF+  E   
Sbjct: 601 TIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYV 660

Query: 666 SPIDSADDLAKQ------TKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVK 719
             +    D   Q          +G V +G+T    +++  + Y +M A+M         K
Sbjct: 661 DQVSGLSDKKFQRPNDFSPPFRFGTVPNGST----ERNIRNNYAEMHAYMG--------K 708

Query: 720 SNEEGIQRVLTSDY-----AFLMESTTIEFVTQRN--CNLTQIGG--LIDSKGYGVGTPM 770
            N+ G+   L S       AF+ ++  + ++  R+  C L  IG   +  S GYG+    
Sbjct: 709 FNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQK 768

Query: 771 GSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAG 830
            S ++ ++ +AILQL  +G++  ++  W  G    E+    +S L + N+ G+F +L A 
Sbjct: 769 DSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAA 828

Query: 831 LVLSVFVAVGEFLY 844
           + LS+   + E L+
Sbjct: 829 MALSLITFICEHLF 842


>gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2
           precursor [Homo sapiens]
          Length = 1281

 Score =  188 bits (477), Expect = 2e-47
 Identities = 182/694 (26%), Positives = 318/694 (45%), Gaps = 111/694 (15%)

Query: 204 LPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFA 263
           L    +DAK  + ++K+     ++  CS + A  IL +A ++G+    + +I  +L    
Sbjct: 206 LDTSFEDAKTQV-QLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGN 264

Query: 264 LDVEPYRY-SGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAAL 322
            ++ P  + SG+              +S   + W    L+A  +   G+L    TT A+ 
Sbjct: 265 TELIPKEFPSGL--------------ISVSYDDWDYS-LEARVRDGIGIL----TTAASS 305

Query: 323 MYDAVHVVSVAVQQ-FPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTN 381
           M +    +  A    + QM    +  +   P+              W+G     T     
Sbjct: 306 MLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVT---------WDGKDLSFT---EE 353

Query: 382 GLRTDFDLDVISL-KEEGLEKIGTWDPASGLNMTESQKGKPANITD-SLSNRSLIVTTIL 439
           G +    L VI L K+   EK+G W+  + L++  +   +  + +D    +  L + T+ 
Sbjct: 354 GYQVHPRLVVIVLNKDREWEKVGKWENHT-LSLRHAVWPRYKSFSDCEPDDNHLSIVTLE 412

Query: 440 EEPYVLFKKSDKPL----------------YGNDRFEG---------YCIDLLRELSTIL 474
           E P+V+ +  D PL                  N   EG         +CID+L++LS  +
Sbjct: 413 EAPFVIVEDID-PLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTV 471

Query: 475 GFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFM 534
            FTY++ LV +GK+G +   N  WNGM+ E++  +A +AV  L I   R +V+DFS PF+
Sbjct: 472 KFTYDLYLVTNGKHGKK--VNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFV 529

Query: 535 TLGISILYRKPNGT-NPGVFSFLNPLSPDIWMYILLAYLGVSCV-LFVIARFSPYEWYNP 592
             GIS++  + NGT +P   +FL P S  +W+ + +  L VS + +FV   FSP   YN 
Sbjct: 530 ETGISVMVSRSNGTVSPS--AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVG-YNR 586

Query: 593 H------PCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM-PKALSTRIVGGIWWFFTL 645
           +      P  P       +FT+  + W   G +      +  PK  +++I+  +W FF +
Sbjct: 587 NLAKGKAPHGP-------SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAV 639

Query: 646 IIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEY------GAVEDGATMTFFKKSKI 699
           I ++SYTANLAAF+  E     +    D   Q   +Y      G V +G+T    +++  
Sbjct: 640 IFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGST----ERNIR 695

Query: 700 STYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDY-----AFLMESTTIEFVTQRN--CNL 752
           + Y  M  +M+        K N++G++  L S       AF+ ++  + +   R+  C L
Sbjct: 696 NNYPYMHQYMT--------KFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKL 747

Query: 753 TQIGG--LIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESK 810
             IG   +  + GYG+    GSP++ +I +A+LQ   +G++  ++  W  G    E+   
Sbjct: 748 VTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEV 807

Query: 811 EASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLY 844
            +S L + N+ G+F +LAA + LS+   + E L+
Sbjct: 808 MSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF 841


>gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1
           precursor [Homo sapiens]
          Length = 1464

 Score =  188 bits (477), Expect = 2e-47
 Identities = 182/694 (26%), Positives = 318/694 (45%), Gaps = 111/694 (15%)

Query: 204 LPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFA 263
           L    +DAK  + ++K+     ++  CS + A  IL +A ++G+    + +I  +L    
Sbjct: 206 LDTSFEDAKTQV-QLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGN 264

Query: 264 LDVEPYRY-SGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAAL 322
            ++ P  + SG+              +S   + W    L+A  +   G+L    TT A+ 
Sbjct: 265 TELIPKEFPSGL--------------ISVSYDDWDYS-LEARVRDGIGIL----TTAASS 305

Query: 323 MYDAVHVVSVAVQQ-FPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTN 381
           M +    +  A    + QM    +  +   P+              W+G     T     
Sbjct: 306 MLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVT---------WDGKDLSFT---EE 353

Query: 382 GLRTDFDLDVISL-KEEGLEKIGTWDPASGLNMTESQKGKPANITD-SLSNRSLIVTTIL 439
           G +    L VI L K+   EK+G W+  + L++  +   +  + +D    +  L + T+ 
Sbjct: 354 GYQVHPRLVVIVLNKDREWEKVGKWENHT-LSLRHAVWPRYKSFSDCEPDDNHLSIVTLE 412

Query: 440 EEPYVLFKKSDKPL----------------YGNDRFEG---------YCIDLLRELSTIL 474
           E P+V+ +  D PL                  N   EG         +CID+L++LS  +
Sbjct: 413 EAPFVIVEDID-PLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTV 471

Query: 475 GFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFM 534
            FTY++ LV +GK+G +   N  WNGM+ E++  +A +AV  L I   R +V+DFS PF+
Sbjct: 472 KFTYDLYLVTNGKHGKK--VNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFV 529

Query: 535 TLGISILYRKPNGT-NPGVFSFLNPLSPDIWMYILLAYLGVSCV-LFVIARFSPYEWYNP 592
             GIS++  + NGT +P   +FL P S  +W+ + +  L VS + +FV   FSP   YN 
Sbjct: 530 ETGISVMVSRSNGTVSPS--AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVG-YNR 586

Query: 593 H------PCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM-PKALSTRIVGGIWWFFTL 645
           +      P  P       +FT+  + W   G +      +  PK  +++I+  +W FF +
Sbjct: 587 NLAKGKAPHGP-------SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAV 639

Query: 646 IIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEY------GAVEDGATMTFFKKSKI 699
           I ++SYTANLAAF+  E     +    D   Q   +Y      G V +G+T    +++  
Sbjct: 640 IFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGST----ERNIR 695

Query: 700 STYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDY-----AFLMESTTIEFVTQRN--CNL 752
           + Y  M  +M+        K N++G++  L S       AF+ ++  + +   R+  C L
Sbjct: 696 NNYPYMHQYMT--------KFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKL 747

Query: 753 TQIGG--LIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESK 810
             IG   +  + GYG+    GSP++ +I +A+LQ   +G++  ++  W  G    E+   
Sbjct: 748 VTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEV 807

Query: 811 EASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLY 844
            +S L + N+ G+F +LAA + LS+   + E L+
Sbjct: 808 MSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF 841


>gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1
           precursor [Homo sapiens]
          Length = 1464

 Score =  188 bits (477), Expect = 2e-47
 Identities = 182/694 (26%), Positives = 318/694 (45%), Gaps = 111/694 (15%)

Query: 204 LPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFA 263
           L    +DAK  + ++K+     ++  CS + A  IL +A ++G+    + +I  +L    
Sbjct: 206 LDTSFEDAKTQV-QLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGN 264

Query: 264 LDVEPYRY-SGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAAL 322
            ++ P  + SG+              +S   + W    L+A  +   G+L    TT A+ 
Sbjct: 265 TELIPKEFPSGL--------------ISVSYDDWDYS-LEARVRDGIGIL----TTAASS 305

Query: 323 MYDAVHVVSVAVQQ-FPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTN 381
           M +    +  A    + QM    +  +   P+              W+G     T     
Sbjct: 306 MLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVT---------WDGKDLSFT---EE 353

Query: 382 GLRTDFDLDVISL-KEEGLEKIGTWDPASGLNMTESQKGKPANITD-SLSNRSLIVTTIL 439
           G +    L VI L K+   EK+G W+  + L++  +   +  + +D    +  L + T+ 
Sbjct: 354 GYQVHPRLVVIVLNKDREWEKVGKWENHT-LSLRHAVWPRYKSFSDCEPDDNHLSIVTLE 412

Query: 440 EEPYVLFKKSDKPL----------------YGNDRFEG---------YCIDLLRELSTIL 474
           E P+V+ +  D PL                  N   EG         +CID+L++LS  +
Sbjct: 413 EAPFVIVEDID-PLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTV 471

Query: 475 GFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFM 534
            FTY++ LV +GK+G +   N  WNGM+ E++  +A +AV  L I   R +V+DFS PF+
Sbjct: 472 KFTYDLYLVTNGKHGKK--VNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFV 529

Query: 535 TLGISILYRKPNGT-NPGVFSFLNPLSPDIWMYILLAYLGVSCV-LFVIARFSPYEWYNP 592
             GIS++  + NGT +P   +FL P S  +W+ + +  L VS + +FV   FSP   YN 
Sbjct: 530 ETGISVMVSRSNGTVSPS--AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVG-YNR 586

Query: 593 H------PCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM-PKALSTRIVGGIWWFFTL 645
           +      P  P       +FT+  + W   G +      +  PK  +++I+  +W FF +
Sbjct: 587 NLAKGKAPHGP-------SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAV 639

Query: 646 IIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEY------GAVEDGATMTFFKKSKI 699
           I ++SYTANLAAF+  E     +    D   Q   +Y      G V +G+T    +++  
Sbjct: 640 IFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGST----ERNIR 695

Query: 700 STYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDY-----AFLMESTTIEFVTQRN--CNL 752
           + Y  M  +M+        K N++G++  L S       AF+ ++  + +   R+  C L
Sbjct: 696 NNYPYMHQYMT--------KFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKL 747

Query: 753 TQIGG--LIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESK 810
             IG   +  + GYG+    GSP++ +I +A+LQ   +G++  ++  W  G    E+   
Sbjct: 748 VTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEV 807

Query: 811 EASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLY 844
            +S L + N+ G+F +LAA + LS+   + E L+
Sbjct: 808 MSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF 841


>gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor
           [Homo sapiens]
          Length = 1336

 Score =  174 bits (442), Expect = 3e-43
 Identities = 135/473 (28%), Positives = 230/473 (48%), Gaps = 54/473 (11%)

Query: 389 LDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKK 448
           L V +L+E     +   DP SG             I DS+  RS +  T    P      
Sbjct: 432 LTVATLEERPFVIVEPADPISG-----------TCIRDSVPCRSQLNRTHSPPP------ 474

Query: 449 SDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDH 508
            D P       +G+CID+L+ L+  +GF+Y++ LV +GK+G + D  G WNGM+ E+   
Sbjct: 475 -DAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKID--GVWNGMIGEVFYQ 531

Query: 509 KADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGT-NPGVFSFLNPLSPDIWMYI 567
           +AD+A+  L I   R +++DFS PF+  GIS++  + NGT +P   +FL P SP +W+ +
Sbjct: 532 RADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPS--AFLEPYSPAVWVMM 589

Query: 568 LLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM 627
            +  L V  V   I  +     YN            + FT+  S W  + AL+   S  +
Sbjct: 590 FVMCLTVVAVTVFIFEYLSPVGYN-RSLATGKRPGGSTFTIGKSIWL-LWALVFNNSVPV 647

Query: 628 --PKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQ------TK 679
             P+  +++I+  +W FF +I ++SYTANLAAF+  E     +    D   Q        
Sbjct: 648 ENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPP 707

Query: 680 IEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDY-----A 734
           +++G V +G+T    +K+  S Y  M ++M        V+ N+  ++  LT        A
Sbjct: 708 LKFGTVPNGST----EKNIRSNYPDMHSYM--------VRYNQPRVEEALTQLKAGKLDA 755

Query: 735 FLMESTTIEFVTQRN--CNLTQIGG--LIDSKGYGVGTPMGSPYRDKITIAILQLQEEGK 790
           F+ ++  + ++ +++  C L  IG   +  + GYG+    GS ++  I +A+LQ   + +
Sbjct: 756 FIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDE 815

Query: 791 LHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFL 843
           + M++  W  G    ++    +S L + N+ G+F +L   + LS+ V   E L
Sbjct: 816 IEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHL 868


>gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor
           [Homo sapiens]
          Length = 1233

 Score =  171 bits (432), Expect = 4e-42
 Identities = 136/496 (27%), Positives = 238/496 (47%), Gaps = 72/496 (14%)

Query: 391 VISLKEEGL-EKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKS 449
           VI+L    L E +G W+               A++   + +R L V T+ E P+V+ +  
Sbjct: 360 VIALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESP 419

Query: 450 DKPLYG------------NDRF-------------EGYCIDLLRELSTILGFTYEIRLVE 484
           D    G            N  F             +G+CID+L++L+ ++ F+Y++ LV 
Sbjct: 420 DPGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVT 479

Query: 485 DGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRK 544
           +GK+G +    G WNGM+ E+   +AD+A+  L I   R +++DFS PF+  GIS++  +
Sbjct: 480 NGKHGKR--VRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVAR 537

Query: 545 PNGT-NPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVE 603
            NGT +P   +FL P SP +W+ +      V C+  V      +E+++P   N +    +
Sbjct: 538 SNGTVSPS--AFLEPYSPAVWVMMF-----VMCLTVVAITVFMFEYFSPVSYNQNLTRGK 590

Query: 604 NN----FTLLNSFWFGVGALMQQGSELM--PKALSTRIVGGIWWFFTLIIISSYTANLAA 657
            +    FT+  S W  + AL+   S  +  P+  +++I+  +W FF +I ++SYTANLAA
Sbjct: 591 KSGGPAFTIGKSVWL-LWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAA 649

Query: 658 FLTVERMESPIDSADDLAKQTK------IEYGAVEDGATMTFFKKSKISTYDKMWAFMSS 711
           F+  E+    +    D   Q          +G V +G+T    +++  S Y  M   M  
Sbjct: 650 FMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGST----ERNIRSNYRDMHTHM-- 703

Query: 712 RRQSVLVKSNEEGIQRVLTSDY-----AFLMESTTIEFVTQRN--CNLTQIGG--LIDSK 762
                 VK N+  ++  LTS       AF+ ++  + ++  ++  C L  IG   +  + 
Sbjct: 704 ------VKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATT 757

Query: 763 GYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGG 822
           GYG+     S ++  I +A+LQ   +G+   ++  W  G    E+    +S L + N+ G
Sbjct: 758 GYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAG 817

Query: 823 IF--IVLAAGLVLSVF 836
           +F  +++A GL L VF
Sbjct: 818 VFYMLLVAMGLALLVF 833


>gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
            [Homo sapiens]
          Length = 1115

 Score =  159 bits (401), Expect = 1e-38
 Identities = 121/466 (25%), Positives = 215/466 (46%), Gaps = 43/466 (9%)

Query: 461  GYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAIT 520
            GYCIDLL +++  + F +++ +V DGKYGA    NG W G+V +L+   A +AV   +I 
Sbjct: 578  GYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWK--NGHWTGLVGDLLRGTAHMAVTSFSIN 635

Query: 521  YVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFV 580
              R +VIDF+ PF +  + IL R  +   P + +F+ PL   +W+ I +A L ++ V   
Sbjct: 636  TARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMWLGIFVA-LHITAVFLT 693

Query: 581  IARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM-PKALSTRIVGGI 639
            +     YEW +P    P        F+  ++       L  +   +  PK  + R +  +
Sbjct: 694  L-----YEWKSPFGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNL 748

Query: 640  WWFFTLIIISSYTANLAAFLTVERMESPIDSADDLA---KQTKIEYGAVEDGATMTFFKK 696
            W  F +  +S+YTANLAA +  E++   +    D           +G V + +   + ++
Sbjct: 749  WAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQ 808

Query: 697  SKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDY---AFLMESTTIEFVT--QRNCN 751
            S    + +M  +M  RR +  V +  +G++ +        AF+M+   +++      +C 
Sbjct: 809  S----FPEMHEYM--RRYN--VPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCK 860

Query: 752  LTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEE--S 809
            L  +G     +GYG+G P  SP    I+  I Q +  G + M+ +KW+R   C +     
Sbjct: 861  LLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAV 920

Query: 810  KEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLY----------KSK-----KNAQLEK 854
             E   +G+++  G+F++L  G  LS+   +GE +           KSK       +Q   
Sbjct: 921  TETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRLH 980

Query: 855  RSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRR 900
            R+  ++ +EE +   K +R  K     P  +      N+   N R+
Sbjct: 981  RAINTSFIEEKQQHFKTKRVEKRSNVGPRQLTVWNTSNLSHDNRRK 1026


>gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
           [Homo sapiens]
          Length = 1043

 Score =  157 bits (398), Expect = 3e-38
 Identities = 121/432 (28%), Positives = 207/432 (47%), Gaps = 35/432 (8%)

Query: 461 GYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAIT 520
           GYCIDLL  L+    F +E+ LV DGKYGA  D  G+W G+V +L+  +A +AV   +I 
Sbjct: 478 GYCIDLLERLAEDTPFDFELYLVGDGKYGALRD--GRWTGLVGDLLAGRAHMAVTSFSIN 535

Query: 521 YVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFV 580
             R +V+DF+ PF +  + I+ R  +  +P + +F+ PL    W       LGV   L +
Sbjct: 536 SARSQVVDFTSPFFSTSLGIMVRARDTASP-IGAFMWPLHWSTW-------LGVFAALHL 587

Query: 581 IARF-SPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQG-SELMPKALSTRIVGG 638
            A F + YEW +P+   P        F+  ++       L ++  S   PK  + R++  
Sbjct: 588 TALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCPTGRLLMN 647

Query: 639 IWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIE---YGAVEDGATMTFFK 695
           +W  F L+++SSYTANLAA +  ++    +    D       +   +G V + +   + K
Sbjct: 648 LWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYIK 707

Query: 696 KSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSD----YAFLMESTTIEFVT--QRN 749
           KS    +  M A M  RR S    +   G+  +LTSD     AF+M+ + +++      +
Sbjct: 708 KS----FPDMHAHM--RRHS--APTTPRGV-AMLTSDPPKLNAFIMDKSLLDYEVSIDAD 758

Query: 750 CNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEE-- 807
           C L  +G     +GYG+G P  SP    ++  I + +  G + ++ +KW++   C +   
Sbjct: 759 CKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVF 818

Query: 808 ESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRM 867
              E   + + +  G+F++L  GL  ++  ++GE  +      ++ K    S +   L  
Sbjct: 819 AVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFFRLALPRIRKG---SRLQYWLHT 875

Query: 868 SLKCQRRLKHKP 879
           S K  R L  +P
Sbjct: 876 SQKIHRALNTEP 887


>gi|116284390 glutamate receptor, ionotrophic, AMPA 4 isoform 3
           precursor [Homo sapiens]
          Length = 433

 Score =  135 bits (339), Expect = 2e-31
 Identities = 115/443 (25%), Positives = 194/443 (43%), Gaps = 37/443 (8%)

Query: 12  VFRRTVKLLLCLLWIGYSQGT-THVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTL 70
           +  R + LL    W G + G     ++ GG+F          E  AFR A+   N +   
Sbjct: 3   IISRQIVLLFSGFW-GLAMGAFPSSVQIGGLF----IRNTDQEYTAFRLAIFLHNTS--- 54

Query: 71  LPNTT-----LTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNAL 125
            PN +     L      I   +SF  +   C Q S GV AIFG     S + + S C+AL
Sbjct: 55  -PNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSAL 113

Query: 126 GVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRL 185
              HI        ++ +  F + L P   SL  A+L L+  ++W     +YD   G   L
Sbjct: 114 ---HISLITPSFPTEGESQFVLQLRP---SLRGALLSLLDHYEWNCFVFLYDTDRGYSIL 167

Query: 186 QELIKAPSRYNLRLK-IRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALA 244
           Q +++   +    +  I     +    + LL+E+ R +E   + DC  E    IL+Q ++
Sbjct: 168 QAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVS 227

Query: 245 MGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAP 304
           +G   + YHYI   L    + +E + + G N+TGF++++     V  ++++W  ++L   
Sbjct: 228 VGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRW--KKLDQR 285

Query: 305 PKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTV--------SSLQCNRHKPWRFG 356
             P S     +    +AL YD V V++   +   +  +             N   PW  G
Sbjct: 286 EYPGSETPPKY---TSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQG 342

Query: 357 TRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTES 416
                 +K+   +GLTG + F+   G R ++ +DV  LK  G  K+G W+    L + + 
Sbjct: 343 IDMERTLKQVRIQGLTGNVQFDH-YGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQD 401

Query: 417 QKGKPANITDSLSNRSLIVTTIL 439
                 N T ++ NR+++VTTI+
Sbjct: 402 VP-TLGNDTAAIENRTVVVTTIM 423


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,288,188
Number of Sequences: 37866
Number of extensions: 1379676
Number of successful extensions: 3134
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 2883
Number of HSP's gapped (non-prelim): 66
length of query: 908
length of database: 18,247,518
effective HSP length: 111
effective length of query: 797
effective length of database: 14,044,392
effective search space: 11193380424
effective search space used: 11193380424
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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