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Search of human proteins with 21314739
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21314739 solute carrier family 25, member 32 [Homo sapiens]
(315 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21314739 solute carrier family 25, member 32 [Homo sapiens] 640 0.0
gi|157388989 solute carrier family 25, member 36 isoform a [Homo... 129 3e-30
gi|157388991 solute carrier family 25, member 36 isoform b [Homo... 124 1e-28
gi|86198310 solute carrier family 25, member 29 [Homo sapiens] 122 4e-28
gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo ... 119 5e-27
gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo s... 119 5e-27
gi|48476342 solute carrier family 25, member 23 [Homo sapiens] 115 5e-26
gi|239755176 PREDICTED: similar to solute carrier family 25, mem... 113 2e-25
gi|239755174 PREDICTED: similar to solute carrier family 25, mem... 113 2e-25
gi|56699407 solute carrier family 25, member 25 isoform c [Homo ... 113 2e-25
gi|56699401 solute carrier family 25, member 25 isoform a [Homo ... 113 2e-25
gi|56699405 solute carrier family 25, member 25 isoform d [Homo ... 113 2e-25
gi|56699403 solute carrier family 25, member 25 isoform b [Homo ... 113 2e-25
gi|14150082 mitochondrial carrier protein MGC4399 [Homo sapiens] 110 1e-24
gi|5453918 solute carrier family 25 (mitochondrial carrier; pero... 110 1e-24
gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens] 104 9e-23
gi|55749577 solute carrier family 25 (mitochondrial carrier; ade... 99 6e-21
gi|156071459 solute carrier family 25, member 5 [Homo sapiens] 99 6e-21
gi|156071462 solute carrier family 25, member A6 [Homo sapiens] 98 8e-21
gi|13775208 solute carrier family 25 (mitochondrial carrier; ade... 97 1e-20
gi|149274607 solute carrier family 25, member 41 [Homo sapiens] 97 2e-20
gi|116235462 solute carrier family 25, member 45 isoform a [Homo... 96 5e-20
gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Ho... 95 9e-20
gi|13259543 solute carrier family 25, member 14 isoform UCP5S [H... 94 1e-19
gi|46409330 solute carrier family 25, member 34 [Homo sapiens] 94 2e-19
gi|58197562 solute carrier family 25, member 30 [Homo sapiens] 93 3e-19
gi|82775373 solute carrier family 25, member 37 [Homo sapiens] 91 2e-18
gi|21389315 solute carrier family 25 (mitochondrial carrier; cit... 88 9e-18
gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens] 86 3e-17
gi|157388925 solute carrier family 25, member 38 [Homo sapiens] 86 4e-17
>gi|21314739 solute carrier family 25, member 32 [Homo sapiens]
Length = 315
Score = 640 bits (1651), Expect = 0.0
Identities = 315/315 (100%), Positives = 315/315 (100%)
Query: 1 MTGQGQSASGSSAWSTVFRHVRYENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRP 60
MTGQGQSASGSSAWSTVFRHVRYENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRP
Sbjct: 1 MTGQGQSASGSSAWSTVFRHVRYENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRP 60
Query: 61 KYNGILHCLTTIWKLDGLRGLYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEA 120
KYNGILHCLTTIWKLDGLRGLYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEA
Sbjct: 61 KYNGILHCLTTIWKLDGLRGLYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEA 120
Query: 121 TEYLVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVR 180
TEYLVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVR
Sbjct: 121 TEYLVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVR 180
Query: 181 GLYKGFVPGLFGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVA 240
GLYKGFVPGLFGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVA
Sbjct: 181 GLYKGFVPGLFGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVA 240
Query: 241 ATYPYQVVRARLQDQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVY 300
ATYPYQVVRARLQDQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVY
Sbjct: 241 ATYPYQVVRARLQDQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVY 300
Query: 301 ENVSHFLLDLREKRK 315
ENVSHFLLDLREKRK
Sbjct: 301 ENVSHFLLDLREKRK 315
>gi|157388989 solute carrier family 25, member 36 isoform a [Homo
sapiens]
Length = 311
Score = 129 bits (325), Expect = 3e-30
Identities = 91/306 (29%), Positives = 145/306 (47%), Gaps = 28/306 (9%)
Query: 25 NLIAGVSGGVLSNLALHPLDLVKIRFAVSD--------------GLEL-RPKYNGILHCL 69
+L AG GG + + PL++VK R S G + R G LHCL
Sbjct: 9 HLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVVSPGPLHCL 68
Query: 70 TTIWKLDGLRGLYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAE 129
I + +G R L++G+ PN+ G S +YF Y+ K K + +++SAA
Sbjct: 69 KVILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKE-KLNDVFDPDSTQVHMISAAM 127
Query: 130 AGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPG 189
AG + TNP+W+ KTRL L DA R G F+ + K+Y+ +G++G Y+G
Sbjct: 128 AGFTAITATNPIWLIKTRLQL--DARNRGERRM--GAFECVRKVYQTDGLKGFYRGMSAS 183
Query: 190 LFGTSHGALQFMAYELLKLKYNQH-----INRLPEAQLSTVEYISV---AALSKIFAVAA 241
G S + F+ YE +K K ++ + E+ +++ + AA SK A
Sbjct: 184 YAGISETVIHFVIYESIKQKLLEYKTASTMENDEESVKEASDFVGMMLAAATSKTCATTI 243
Query: 242 TYPYQVVRARLQDQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYE 301
YP++VVR RL+++ Y ++ ++EG G Y+G+ +L+R P I YE
Sbjct: 244 AYPHEVVRTRLREEGTKYRSFFQTLSLLVQEEGYGSLYRGLTTHLVRQIPNTAIMMATYE 303
Query: 302 NVSHFL 307
V + L
Sbjct: 304 LVVYLL 309
Score = 35.8 bits (81), Expect = 0.051
Identities = 25/111 (22%), Positives = 40/111 (36%), Gaps = 20/111 (18%)
Query: 220 AQLSTVEYISVAALSKIFAVAATYPYQVVRARLQDQ--------------------HMFY 259
+Q T+ ++ T P +VV+ RLQ +
Sbjct: 2 SQRDTLVHLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVVS 61
Query: 260 SGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHFLLDL 310
G + + KEG ++G+ PNL+ V P+ I F Y N L D+
Sbjct: 62 PGPLHCLKVILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNDV 112
>gi|157388991 solute carrier family 25, member 36 isoform b [Homo
sapiens]
Length = 310
Score = 124 bits (311), Expect = 1e-28
Identities = 91/306 (29%), Positives = 144/306 (47%), Gaps = 29/306 (9%)
Query: 25 NLIAGVSGGVLSNLALHPLDLVKIRFAVSD--------------GLEL-RPKYNGILHCL 69
+L AG GG + + PL++VK R S G + R G LHCL
Sbjct: 9 HLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVVSPGPLHCL 68
Query: 70 TTIWKLDGLRGLYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAE 129
I + +G R L++G+ PN+ G S +YF Y+ K K + +++SAA
Sbjct: 69 KVILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKE-KLNDVFDPDSTQVHMISAAM 127
Query: 130 AGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPG 189
AG + TNP+W+ KTRL L DA R G F+ + K+Y+ +G++G Y+G
Sbjct: 128 AGFTAITATNPIWLIKTRLQL--DARNRGERRM--GAFECVRKVYQTDGLKGFYRGMSAS 183
Query: 190 LFGTSHGALQFMAYELLKLKYNQH-----INRLPEAQLSTVEYISV---AALSKIFAVAA 241
G S + F+ YE +K K ++ + E+ +++ + AA SK A
Sbjct: 184 YAGISETVIHFVIYESIKQKLLEYKTASTMENDEESVKEASDFVGMMLAAATSKTCATTI 243
Query: 242 TYPYQVVRARLQDQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYE 301
YP+ VVR RL+++ Y ++ ++EG G Y+G+ +L+R P I YE
Sbjct: 244 AYPH-VVRTRLREEGTKYRSFFQTLSLLVQEEGYGSLYRGLTTHLVRQIPNTAIMMATYE 302
Query: 302 NVSHFL 307
V + L
Sbjct: 303 LVVYLL 308
Score = 35.8 bits (81), Expect = 0.051
Identities = 25/111 (22%), Positives = 40/111 (36%), Gaps = 20/111 (18%)
Query: 220 AQLSTVEYISVAALSKIFAVAATYPYQVVRARLQDQ--------------------HMFY 259
+Q T+ ++ T P +VV+ RLQ +
Sbjct: 2 SQRDTLVHLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVVS 61
Query: 260 SGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHFLLDL 310
G + + KEG ++G+ PNL+ V P+ I F Y N L D+
Sbjct: 62 PGPLHCLKVILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNDV 112
>gi|86198310 solute carrier family 25, member 29 [Homo sapiens]
Length = 303
Score = 122 bits (306), Expect = 4e-28
Identities = 90/278 (32%), Positives = 136/278 (48%), Gaps = 20/278 (7%)
Query: 25 NLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLYQG 84
+ +AG +GGV L HP D VK+R V +P+Y G LHC +I K + + GLY+G
Sbjct: 4 DFLAGCAGGVAGVLVGHPFDTVKVRLQVQS--VEKPQYRGTLHCFKSIIKQESVLGLYKG 61
Query: 85 VTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLCITNPLWVT 144
+ + G L F ++ ++L AA AGA+ I P+ +
Sbjct: 62 LGSPLMGLTFINALVF----GVQGNTLRALGHDSPLNQFLAGAA-AGAIQCVICCPMELA 116
Query: 145 KTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLF-GTSHGALQFMAY 203
KTRL LQ DA P R YKG D L +IY +EG+RG+ +G V L T + F+ Y
Sbjct: 117 KTRLQLQ-DA---GPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGVYFLTY 172
Query: 204 ELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARLQDQHM----FY 259
+ L + + P +L + + S I + +TYP VV++RLQ + Y
Sbjct: 173 DAL----TRALGCEPGDRLLVPKLLLAGGTSGIVSWLSTYPVDVVKSRLQADGLRGAPRY 228
Query: 260 SGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITF 297
G++D + +++R EG F +G+A L+R P TF
Sbjct: 229 RGILDCVHQSYRAEGWRVFTRGLASTLLRAFPVNAATF 266
Score = 56.6 bits (135), Expect = 3e-08
Identities = 55/195 (28%), Positives = 86/195 (44%), Gaps = 24/195 (12%)
Query: 120 ATEYLVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGV 179
A ++L A G + + +P K RL +Q V P QY+G I K E V
Sbjct: 2 ALDFLAGCA-GGVAGVLVGHPFDTVKVRLQVQS---VEKP--QYRGTLHCFKSIIKQESV 55
Query: 180 RGLYKGFVPGLFG-TSHGALQF--MAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKI 236
GLYKG L G T AL F L L ++ +N ++++ AA I
Sbjct: 56 LGLYKGLGSPLMGLTFINALVFGVQGNTLRALGHDSPLN----------QFLAGAAAGAI 105
Query: 237 FAVAATYPYQVVRARLQDQHM----FYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPA 292
V P ++ + RLQ Q Y G +D + + + EG+ G +G+ L+R TP+
Sbjct: 106 QCVICC-PMELAKTRLQLQDAGPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPS 164
Query: 293 CCITFVVYENVSHFL 307
+ F+ Y+ ++ L
Sbjct: 165 FGVYFLTYDALTRAL 179
>gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo
sapiens]
Length = 477
Score = 119 bits (297), Expect = 5e-27
Identities = 86/290 (29%), Positives = 132/290 (45%), Gaps = 17/290 (5%)
Query: 23 YENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLY 82
+ L+AG G +S + PLD +KI V + G + K G+R L+
Sbjct: 195 WRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMV---KEGGIRSLW 251
Query: 83 QGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLCITNPLW 142
+G N+ + F+ Y K TE +++ E +S + AGA P+
Sbjct: 252 RGNGTNVIKIAPETAVKFWAYEQYKKLLTE-EGQKIGTFERFISGSMAGATAQTFIYPME 310
Query: 143 VTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGT-SHGALQFM 201
V KTRL + QY G++D KI K+EG+ YKG+VP L G + +
Sbjct: 311 VMKTRLAVGKTG-------QYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLA 363
Query: 202 AYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARLQDQHMFYSG 261
YELLK + + + + + ALS A+YP +VR R+Q Q M
Sbjct: 364 VYELLKSYWLDNFAK-DSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGS 422
Query: 262 ----VIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHFL 307
++ + + KEG+ G Y+GI PN ++V PA I++VVYEN+ L
Sbjct: 423 PQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTL 472
Score = 65.9 bits (159), Expect = 5e-11
Identities = 52/188 (27%), Positives = 88/188 (46%), Gaps = 13/188 (6%)
Query: 124 LVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLY 183
L++ AGA++ T PL + ++M+Q V+ +F ++ K G+R L+
Sbjct: 198 LLAGGIAGAVSRTSTAPL--DRLKIMMQ----VHGSKSDKMNIFGGFRQMVKEGGIRSLW 251
Query: 184 KGFVPGLFGTS-HGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAAT 242
+G + + A++F AYE K + ++ T E +++ A
Sbjct: 252 RGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKI-----GTFERFISGSMAGATAQTFI 306
Query: 243 YPYQVVRARLQ-DQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYE 301
YP +V++ RL + YSG+ D K + EG+G FYKG PNL+ + P I VYE
Sbjct: 307 YPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYE 366
Query: 302 NVSHFLLD 309
+ + LD
Sbjct: 367 LLKSYWLD 374
>gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo
sapiens]
Length = 458
Score = 119 bits (297), Expect = 5e-27
Identities = 86/290 (29%), Positives = 132/290 (45%), Gaps = 17/290 (5%)
Query: 23 YENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLY 82
+ L+AG G +S + PLD +KI V + G + K G+R L+
Sbjct: 176 WRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMV---KEGGIRSLW 232
Query: 83 QGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLCITNPLW 142
+G N+ + F+ Y K TE +++ E +S + AGA P+
Sbjct: 233 RGNGTNVIKIAPETAVKFWAYEQYKKLLTE-EGQKIGTFERFISGSMAGATAQTFIYPME 291
Query: 143 VTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGT-SHGALQFM 201
V KTRL + QY G++D KI K+EG+ YKG+VP L G + +
Sbjct: 292 VMKTRLAVGKTG-------QYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLA 344
Query: 202 AYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARLQDQHMFYSG 261
YELLK + + + + + ALS A+YP +VR R+Q Q M
Sbjct: 345 VYELLKSYWLDNFAK-DSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGS 403
Query: 262 ----VIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHFL 307
++ + + KEG+ G Y+GI PN ++V PA I++VVYEN+ L
Sbjct: 404 PQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTL 453
Score = 65.9 bits (159), Expect = 5e-11
Identities = 52/188 (27%), Positives = 88/188 (46%), Gaps = 13/188 (6%)
Query: 124 LVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLY 183
L++ AGA++ T PL + ++M+Q V+ +F ++ K G+R L+
Sbjct: 179 LLAGGIAGAVSRTSTAPL--DRLKIMMQ----VHGSKSDKMNIFGGFRQMVKEGGIRSLW 232
Query: 184 KGFVPGLFGTS-HGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAAT 242
+G + + A++F AYE K + ++ T E +++ A
Sbjct: 233 RGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKI-----GTFERFISGSMAGATAQTFI 287
Query: 243 YPYQVVRARLQ-DQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYE 301
YP +V++ RL + YSG+ D K + EG+G FYKG PNL+ + P I VYE
Sbjct: 288 YPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYE 347
Query: 302 NVSHFLLD 309
+ + LD
Sbjct: 348 LLKSYWLD 355
>gi|48476342 solute carrier family 25, member 23 [Homo sapiens]
Length = 468
Score = 115 bits (288), Expect = 5e-26
Identities = 87/290 (30%), Positives = 135/290 (46%), Gaps = 17/290 (5%)
Query: 23 YENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLY 82
++ L+AG G +S PLD +K+ V R IL L ++ G+R L+
Sbjct: 186 WKQLVAGAVAGAVSRTGTAPLDRLKVFMQVHASKTNRLN---ILGGLRSMVLEGGIRSLW 242
Query: 83 QGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLCITNPLW 142
+G N+ + F Y IK G+ E L E V+ + AGA I P+
Sbjct: 243 RGNGINVLKIAPESAIKFMAYEQIKR-AILGQQETLHVQERFVAGSLAGATAQTIIYPME 301
Query: 143 VTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGT-SHGALQFM 201
V KTRL L+ QYKG+ D +I + EG R Y+G++P + G + +
Sbjct: 302 VLKTRLTLRRTG-------QYKGLLDCARRILEREGPRAFYRGYLPNVLGIIPYAGIDLA 354
Query: 202 AYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARLQDQHMFYSG 261
YE LK + Q + A + ++ +S A+YP +VR R+Q Q G
Sbjct: 355 VYETLKNWWLQQYSH-DSADPGILVLLACGTISSTCGQIASYPLALVRTRMQAQASIEGG 413
Query: 262 ----VIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHFL 307
++ ++ +EG+ G Y+GIAPN ++V PA I++VVYEN+ L
Sbjct: 414 PQLSMLGLLRHILSQEGMRGLYRGIAPNFMKVIPAVSISYVVYENMKQAL 463
Score = 55.5 bits (132), Expect = 6e-08
Identities = 49/187 (26%), Positives = 86/187 (45%), Gaps = 13/187 (6%)
Query: 124 LVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLY 183
LV+ A AGA++ T PL + ++ +Q A + G+ +++ G+R L+
Sbjct: 189 LVAGAVAGAVSRTGTAPL--DRLKVFMQVHASKTNRLNILGGLRSMVLE----GGIRSLW 242
Query: 184 KGF-VPGLFGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAAT 242
+G + L A++FMAYE +K + L E +L+ A
Sbjct: 243 RGNGINVLKIAPESAIKFMAYEQIKRAILGQ-----QETLHVQERFVAGSLAGATAQTII 297
Query: 243 YPYQVVRARLQDQHMF-YSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYE 301
YP +V++ RL + Y G++D + +EG FY+G PN++ + P I VYE
Sbjct: 298 YPMEVLKTRLTLRRTGQYKGLLDCARRILEREGPRAFYRGYLPNVLGIIPYAGIDLAVYE 357
Query: 302 NVSHFLL 308
+ ++ L
Sbjct: 358 TLKNWWL 364
>gi|239755176 PREDICTED: similar to solute carrier family 25, member
25 isoform 2 [Homo sapiens]
Length = 469
Score = 113 bits (283), Expect = 2e-25
Identities = 86/286 (30%), Positives = 128/286 (44%), Gaps = 17/286 (5%)
Query: 23 YENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLY 82
+ +L+AG G +S PLD +K+ V R GI+ T + + G R L+
Sbjct: 187 WRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHAS---RSNNMGIVGGFTQMIREGGARSLW 243
Query: 83 QGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLCITNPLW 142
+G N+ + F Y IK + E L E LV+ + AGA+ P+
Sbjct: 244 RGNGINVLKIAPESAIKFMAYEQIKRLVGSDQ-ETLRIHERLVAGSLAGAIAQSSIYPME 302
Query: 143 VTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGT-SHGALQFM 201
V KTR+ L+ QY GM D +I EGV YKG+VP + G + +
Sbjct: 303 VLKTRMALRKTG-------QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLA 355
Query: 202 AYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARLQDQHMFYSG 261
YE LK + QH + A ++ +S A+YP +VR R+Q Q
Sbjct: 356 VYETLKNAWLQHY-AVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGA 414
Query: 262 ----VIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENV 303
+ + R EG G Y+G+APN ++V PA I++VVYEN+
Sbjct: 415 PEVTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENL 460
Score = 66.2 bits (160), Expect = 4e-11
Identities = 49/185 (26%), Positives = 90/185 (48%), Gaps = 13/185 (7%)
Query: 123 YLVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGL 182
+LV+ AGA++ T PL + ++++Q V++ G+ ++ + G R L
Sbjct: 189 HLVAGGGAGAVSRTCTAPL--DRLKVLMQ----VHASRSNNMGIVGGFTQMIREGGARSL 242
Query: 183 YKGF-VPGLFGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAA 241
++G + L A++FMAYE +K + L E + +L+ A ++
Sbjct: 243 WRGNGINVLKIAPESAIKFMAYEQIKRLVGSD-----QETLRIHERLVAGSLAGAIAQSS 297
Query: 242 TYPYQVVRARLQDQHMF-YSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVY 300
YP +V++ R+ + YSG++D + +EGV FYKG PN++ + P I VY
Sbjct: 298 IYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVY 357
Query: 301 ENVSH 305
E + +
Sbjct: 358 ETLKN 362
Score = 32.3 bits (72), Expect = 0.56
Identities = 21/82 (25%), Positives = 34/82 (41%), Gaps = 1/82 (1%)
Query: 26 LIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLYQGV 85
L G LA +PL LV+ R +E P+ + I + +G GLY+G+
Sbjct: 381 LACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVT-MSSLFKHILRTEGAFGLYRGL 439
Query: 86 TPNIWGAGLSWGLYFFFYNAIK 107
PN + + + Y +K
Sbjct: 440 APNFMKVIPAVSISYVVYENLK 461
Score = 30.4 bits (67), Expect = 2.1
Identities = 11/47 (23%), Positives = 24/47 (51%)
Query: 261 GVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHFL 307
G++ T+ R+ G ++G N++++ P I F+ YE + +
Sbjct: 225 GIVGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRLV 271
>gi|239755174 PREDICTED: similar to solute carrier family 25, member
25 isoform 1 [Homo sapiens]
Length = 503
Score = 113 bits (283), Expect = 2e-25
Identities = 86/286 (30%), Positives = 128/286 (44%), Gaps = 17/286 (5%)
Query: 23 YENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLY 82
+ +L+AG G +S PLD +K+ V R GI+ T + + G R L+
Sbjct: 221 WRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHAS---RSNNMGIVGGFTQMIREGGARSLW 277
Query: 83 QGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLCITNPLW 142
+G N+ + F Y IK + E L E LV+ + AGA+ P+
Sbjct: 278 RGNGINVLKIAPESAIKFMAYEQIKRLVGSDQ-ETLRIHERLVAGSLAGAIAQSSIYPME 336
Query: 143 VTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGT-SHGALQFM 201
V KTR+ L+ QY GM D +I EGV YKG+VP + G + +
Sbjct: 337 VLKTRMALRKTG-------QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLA 389
Query: 202 AYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARLQDQHMFYSG 261
YE LK + QH + A ++ +S A+YP +VR R+Q Q
Sbjct: 390 VYETLKNAWLQHY-AVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGA 448
Query: 262 ----VIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENV 303
+ + R EG G Y+G+APN ++V PA I++VVYEN+
Sbjct: 449 PEVTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENL 494
Score = 66.2 bits (160), Expect = 4e-11
Identities = 49/185 (26%), Positives = 90/185 (48%), Gaps = 13/185 (7%)
Query: 123 YLVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGL 182
+LV+ AGA++ T PL + ++++Q V++ G+ ++ + G R L
Sbjct: 223 HLVAGGGAGAVSRTCTAPL--DRLKVLMQ----VHASRSNNMGIVGGFTQMIREGGARSL 276
Query: 183 YKGF-VPGLFGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAA 241
++G + L A++FMAYE +K + L E + +L+ A ++
Sbjct: 277 WRGNGINVLKIAPESAIKFMAYEQIKRLVGSD-----QETLRIHERLVAGSLAGAIAQSS 331
Query: 242 TYPYQVVRARLQDQHMF-YSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVY 300
YP +V++ R+ + YSG++D + +EGV FYKG PN++ + P I VY
Sbjct: 332 IYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVY 391
Query: 301 ENVSH 305
E + +
Sbjct: 392 ETLKN 396
Score = 32.3 bits (72), Expect = 0.56
Identities = 21/82 (25%), Positives = 34/82 (41%), Gaps = 1/82 (1%)
Query: 26 LIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLYQGV 85
L G LA +PL LV+ R +E P+ + I + +G GLY+G+
Sbjct: 415 LACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVT-MSSLFKHILRTEGAFGLYRGL 473
Query: 86 TPNIWGAGLSWGLYFFFYNAIK 107
PN + + + Y +K
Sbjct: 474 APNFMKVIPAVSISYVVYENLK 495
Score = 30.4 bits (67), Expect = 2.1
Identities = 11/47 (23%), Positives = 24/47 (51%)
Query: 261 GVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHFL 307
G++ T+ R+ G ++G N++++ P I F+ YE + +
Sbjct: 259 GIVGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRLV 305
>gi|56699407 solute carrier family 25, member 25 isoform c [Homo
sapiens]
Length = 489
Score = 113 bits (283), Expect = 2e-25
Identities = 86/286 (30%), Positives = 128/286 (44%), Gaps = 17/286 (5%)
Query: 23 YENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLY 82
+ +L+AG G +S PLD +K+ V R GI+ T + + G R L+
Sbjct: 207 WRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHAS---RSNNMGIVGGFTQMIREGGARSLW 263
Query: 83 QGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLCITNPLW 142
+G N+ + F Y IK + E L E LV+ + AGA+ P+
Sbjct: 264 RGNGINVLKIAPESAIKFMAYEQIKRLVGSDQ-ETLRIHERLVAGSLAGAIAQSSIYPME 322
Query: 143 VTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGT-SHGALQFM 201
V KTR+ L+ QY GM D +I EGV YKG+VP + G + +
Sbjct: 323 VLKTRMALRKTG-------QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLA 375
Query: 202 AYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARLQDQHMFYSG 261
YE LK + QH + A ++ +S A+YP +VR R+Q Q
Sbjct: 376 VYETLKNAWLQHY-AVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGA 434
Query: 262 ----VIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENV 303
+ + R EG G Y+G+APN ++V PA I++VVYEN+
Sbjct: 435 PEVTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENL 480
Score = 66.2 bits (160), Expect = 4e-11
Identities = 49/185 (26%), Positives = 90/185 (48%), Gaps = 13/185 (7%)
Query: 123 YLVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGL 182
+LV+ AGA++ T PL + ++++Q V++ G+ ++ + G R L
Sbjct: 209 HLVAGGGAGAVSRTCTAPL--DRLKVLMQ----VHASRSNNMGIVGGFTQMIREGGARSL 262
Query: 183 YKGF-VPGLFGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAA 241
++G + L A++FMAYE +K + L E + +L+ A ++
Sbjct: 263 WRGNGINVLKIAPESAIKFMAYEQIKRLVGSD-----QETLRIHERLVAGSLAGAIAQSS 317
Query: 242 TYPYQVVRARLQDQHMF-YSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVY 300
YP +V++ R+ + YSG++D + +EGV FYKG PN++ + P I VY
Sbjct: 318 IYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVY 377
Query: 301 ENVSH 305
E + +
Sbjct: 378 ETLKN 382
Score = 32.3 bits (72), Expect = 0.56
Identities = 21/82 (25%), Positives = 34/82 (41%), Gaps = 1/82 (1%)
Query: 26 LIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLYQGV 85
L G LA +PL LV+ R +E P+ + I + +G GLY+G+
Sbjct: 401 LACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVT-MSSLFKHILRTEGAFGLYRGL 459
Query: 86 TPNIWGAGLSWGLYFFFYNAIK 107
PN + + + Y +K
Sbjct: 460 APNFMKVIPAVSISYVVYENLK 481
Score = 30.4 bits (67), Expect = 2.1
Identities = 11/47 (23%), Positives = 24/47 (51%)
Query: 261 GVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHFL 307
G++ T+ R+ G ++G N++++ P I F+ YE + +
Sbjct: 245 GIVGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRLV 291
>gi|56699401 solute carrier family 25, member 25 isoform a [Homo
sapiens]
Length = 469
Score = 113 bits (283), Expect = 2e-25
Identities = 86/286 (30%), Positives = 128/286 (44%), Gaps = 17/286 (5%)
Query: 23 YENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLY 82
+ +L+AG G +S PLD +K+ V R GI+ T + + G R L+
Sbjct: 187 WRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHAS---RSNNMGIVGGFTQMIREGGARSLW 243
Query: 83 QGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLCITNPLW 142
+G N+ + F Y IK + E L E LV+ + AGA+ P+
Sbjct: 244 RGNGINVLKIAPESAIKFMAYEQIKRLVGSDQ-ETLRIHERLVAGSLAGAIAQSSIYPME 302
Query: 143 VTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGT-SHGALQFM 201
V KTR+ L+ QY GM D +I EGV YKG+VP + G + +
Sbjct: 303 VLKTRMALRKTG-------QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLA 355
Query: 202 AYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARLQDQHMFYSG 261
YE LK + QH + A ++ +S A+YP +VR R+Q Q
Sbjct: 356 VYETLKNAWLQHY-AVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGA 414
Query: 262 ----VIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENV 303
+ + R EG G Y+G+APN ++V PA I++VVYEN+
Sbjct: 415 PEVTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENL 460
Score = 66.2 bits (160), Expect = 4e-11
Identities = 49/185 (26%), Positives = 90/185 (48%), Gaps = 13/185 (7%)
Query: 123 YLVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGL 182
+LV+ AGA++ T PL + ++++Q V++ G+ ++ + G R L
Sbjct: 189 HLVAGGGAGAVSRTCTAPL--DRLKVLMQ----VHASRSNNMGIVGGFTQMIREGGARSL 242
Query: 183 YKGF-VPGLFGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAA 241
++G + L A++FMAYE +K + L E + +L+ A ++
Sbjct: 243 WRGNGINVLKIAPESAIKFMAYEQIKRLVGSD-----QETLRIHERLVAGSLAGAIAQSS 297
Query: 242 TYPYQVVRARLQDQHMF-YSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVY 300
YP +V++ R+ + YSG++D + +EGV FYKG PN++ + P I VY
Sbjct: 298 IYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVY 357
Query: 301 ENVSH 305
E + +
Sbjct: 358 ETLKN 362
Score = 32.3 bits (72), Expect = 0.56
Identities = 21/82 (25%), Positives = 34/82 (41%), Gaps = 1/82 (1%)
Query: 26 LIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLYQGV 85
L G LA +PL LV+ R +E P+ + I + +G GLY+G+
Sbjct: 381 LACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVT-MSSLFKHILRTEGAFGLYRGL 439
Query: 86 TPNIWGAGLSWGLYFFFYNAIK 107
PN + + + Y +K
Sbjct: 440 APNFMKVIPAVSISYVVYENLK 461
Score = 30.4 bits (67), Expect = 2.1
Identities = 11/47 (23%), Positives = 24/47 (51%)
Query: 261 GVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHFL 307
G++ T+ R+ G ++G N++++ P I F+ YE + +
Sbjct: 225 GIVGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRLV 271
>gi|56699405 solute carrier family 25, member 25 isoform d [Homo
sapiens]
Length = 366
Score = 113 bits (283), Expect = 2e-25
Identities = 86/286 (30%), Positives = 128/286 (44%), Gaps = 17/286 (5%)
Query: 23 YENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLY 82
+ +L+AG G +S PLD +K+ V R GI+ T + + G R L+
Sbjct: 84 WRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHAS---RSNNMGIVGGFTQMIREGGARSLW 140
Query: 83 QGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLCITNPLW 142
+G N+ + F Y IK + E L E LV+ + AGA+ P+
Sbjct: 141 RGNGINVLKIAPESAIKFMAYEQIKRLVGSDQ-ETLRIHERLVAGSLAGAIAQSSIYPME 199
Query: 143 VTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGT-SHGALQFM 201
V KTR+ L+ QY GM D +I EGV YKG+VP + G + +
Sbjct: 200 VLKTRMALRKTG-------QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLA 252
Query: 202 AYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARLQDQHMFYSG 261
YE LK + QH + A ++ +S A+YP +VR R+Q Q
Sbjct: 253 VYETLKNAWLQHY-AVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGA 311
Query: 262 ----VIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENV 303
+ + R EG G Y+G+APN ++V PA I++VVYEN+
Sbjct: 312 PEVTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENL 357
Score = 66.2 bits (160), Expect = 4e-11
Identities = 49/185 (26%), Positives = 90/185 (48%), Gaps = 13/185 (7%)
Query: 123 YLVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGL 182
+LV+ AGA++ T PL + ++++Q V++ G+ ++ + G R L
Sbjct: 86 HLVAGGGAGAVSRTCTAPL--DRLKVLMQ----VHASRSNNMGIVGGFTQMIREGGARSL 139
Query: 183 YKGF-VPGLFGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAA 241
++G + L A++FMAYE +K + L E + +L+ A ++
Sbjct: 140 WRGNGINVLKIAPESAIKFMAYEQIKRLVGSD-----QETLRIHERLVAGSLAGAIAQSS 194
Query: 242 TYPYQVVRARLQDQHMF-YSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVY 300
YP +V++ R+ + YSG++D + +EGV FYKG PN++ + P I VY
Sbjct: 195 IYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVY 254
Query: 301 ENVSH 305
E + +
Sbjct: 255 ETLKN 259
Score = 32.3 bits (72), Expect = 0.56
Identities = 21/82 (25%), Positives = 34/82 (41%), Gaps = 1/82 (1%)
Query: 26 LIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLYQGV 85
L G LA +PL LV+ R +E P+ + I + +G GLY+G+
Sbjct: 278 LACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVT-MSSLFKHILRTEGAFGLYRGL 336
Query: 86 TPNIWGAGLSWGLYFFFYNAIK 107
PN + + + Y +K
Sbjct: 337 APNFMKVIPAVSISYVVYENLK 358
Score = 30.4 bits (67), Expect = 2.1
Identities = 11/47 (23%), Positives = 24/47 (51%)
Query: 261 GVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHFL 307
G++ T+ R+ G ++G N++++ P I F+ YE + +
Sbjct: 122 GIVGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRLV 168
>gi|56699403 solute carrier family 25, member 25 isoform b [Homo
sapiens]
Length = 503
Score = 113 bits (283), Expect = 2e-25
Identities = 86/286 (30%), Positives = 128/286 (44%), Gaps = 17/286 (5%)
Query: 23 YENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLY 82
+ +L+AG G +S PLD +K+ V R GI+ T + + G R L+
Sbjct: 221 WRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHAS---RSNNMGIVGGFTQMIREGGARSLW 277
Query: 83 QGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLCITNPLW 142
+G N+ + F Y IK + E L E LV+ + AGA+ P+
Sbjct: 278 RGNGINVLKIAPESAIKFMAYEQIKRLVGSDQ-ETLRIHERLVAGSLAGAIAQSSIYPME 336
Query: 143 VTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGT-SHGALQFM 201
V KTR+ L+ QY GM D +I EGV YKG+VP + G + +
Sbjct: 337 VLKTRMALRKTG-------QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLA 389
Query: 202 AYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARLQDQHMFYSG 261
YE LK + QH + A ++ +S A+YP +VR R+Q Q
Sbjct: 390 VYETLKNAWLQHY-AVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGA 448
Query: 262 ----VIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENV 303
+ + R EG G Y+G+APN ++V PA I++VVYEN+
Sbjct: 449 PEVTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENL 494
Score = 66.2 bits (160), Expect = 4e-11
Identities = 49/185 (26%), Positives = 90/185 (48%), Gaps = 13/185 (7%)
Query: 123 YLVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGL 182
+LV+ AGA++ T PL + ++++Q V++ G+ ++ + G R L
Sbjct: 223 HLVAGGGAGAVSRTCTAPL--DRLKVLMQ----VHASRSNNMGIVGGFTQMIREGGARSL 276
Query: 183 YKGF-VPGLFGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAA 241
++G + L A++FMAYE +K + L E + +L+ A ++
Sbjct: 277 WRGNGINVLKIAPESAIKFMAYEQIKRLVGSD-----QETLRIHERLVAGSLAGAIAQSS 331
Query: 242 TYPYQVVRARLQDQHMF-YSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVY 300
YP +V++ R+ + YSG++D + +EGV FYKG PN++ + P I VY
Sbjct: 332 IYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVY 391
Query: 301 ENVSH 305
E + +
Sbjct: 392 ETLKN 396
Score = 32.3 bits (72), Expect = 0.56
Identities = 21/82 (25%), Positives = 34/82 (41%), Gaps = 1/82 (1%)
Query: 26 LIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLYQGV 85
L G LA +PL LV+ R +E P+ + I + +G GLY+G+
Sbjct: 415 LACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVT-MSSLFKHILRTEGAFGLYRGL 473
Query: 86 TPNIWGAGLSWGLYFFFYNAIK 107
PN + + + Y +K
Sbjct: 474 APNFMKVIPAVSISYVVYENLK 495
Score = 30.4 bits (67), Expect = 2.1
Identities = 11/47 (23%), Positives = 24/47 (51%)
Query: 261 GVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHFL 307
G++ T+ R+ G ++G N++++ P I F+ YE + +
Sbjct: 259 GIVGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRLV 305
>gi|14150082 mitochondrial carrier protein MGC4399 [Homo sapiens]
Length = 321
Score = 110 bits (276), Expect = 1e-24
Identities = 91/315 (28%), Positives = 140/315 (44%), Gaps = 40/315 (12%)
Query: 25 NLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYN--------------------- 63
+L AG GG + + PL+++K R S L LR Y
Sbjct: 14 HLFAGGCGGTVGAIFTCPLEVIKTRLQ-SSRLALRTVYYPQVHLGTISGAGMVRPTSVTP 72
Query: 64 GILHCLTTIWKLDGLRGLYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEY 123
G+ L +I + +G + L++G+ PN+ G S +YF Y+ K + G +
Sbjct: 73 GLFQVLKSILEKEGPKSLFRGLGPNLVGVAPSRAVYFACYSKAKE-QFNGIFVPNSNIVH 131
Query: 124 LVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLV---KIYKYEGVR 180
+ SA A +T + NP+W+ KTR+ L+ R K M +TL +Y+ EG+R
Sbjct: 132 IFSAGSAAFITNSLMNPIWMVKTRMQLEQKV------RGSKQM-NTLQCARYVYQTEGIR 184
Query: 181 GLYKGFVPGLFGTSHGALQFMAYELLKLKYNQHI------NRLPEAQLSTVEYISVAALS 234
G Y+G G S + F YE LK KY + N + S ++ AALS
Sbjct: 185 GFYRGLTASYAGISETIICFAIYESLK-KYLKEAPLASSANGTEKNSTSFFGLMAAAALS 243
Query: 235 KIFAVAATYPYQVVRARLQDQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACC 294
K A YP++V+R RL+++ Y + +R+EG FY+G+ LIR P
Sbjct: 244 KGCASCIAYPHEVIRTRLREEGTKYKSFVQTARLVFREEGYLAFYRGLFAQLIRQIPNTA 303
Query: 295 ITFVVYENVSHFLLD 309
I YE + + L D
Sbjct: 304 IVLSTYELIVYLLED 318
>gi|5453918 solute carrier family 25 (mitochondrial carrier;
peroxisomal membrane protein, 34kDa), member 17 [Homo
sapiens]
Length = 307
Score = 110 bits (276), Expect = 1e-24
Identities = 85/297 (28%), Positives = 143/297 (48%), Gaps = 26/297 (8%)
Query: 23 YENLIAGVSGGVLSNLAL---HPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLR 79
YE+L+ V+G V S A+ PLD ++R V + + + + +L + K +GL
Sbjct: 7 YESLVHAVAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMVLLEII----KEEGLL 62
Query: 80 GLYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLCITN 139
Y+G P I S +YF+ +N++K+ +G + + LV AG + + +T
Sbjct: 63 APYRGWFPVISSLCCSNFVYFYTFNSLKALWVKG--QHSTTGKDLVVGFVAGVVNVLLTT 120
Query: 140 PLWVTKTRLMLQYDAVVNSP--HRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGTSHGA 197
PLWV TRL LQ N YKG+ D +I + EG+ L+ G P L + A
Sbjct: 121 PLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPA 180
Query: 198 LQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVV-------RA 250
+QFM YE LK + + +LS+++ + A++K A TYP Q V R
Sbjct: 181 IQFMFYEGLKRQLLK-----KRMKLSSLDVFIIGAVAKAIATTVTYPLQTVQSILRFGRH 235
Query: 251 RLQDQHMFYS---GVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVS 304
RL ++ ++ ++ + R+ G+ G YKG+ L++ + F+VYE ++
Sbjct: 236 RLNPENRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKLT 292
>gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens]
Length = 301
Score = 104 bits (260), Expect = 9e-23
Identities = 85/289 (29%), Positives = 125/289 (43%), Gaps = 11/289 (3%)
Query: 24 ENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGL--ELRPKYNGILHCLTTIWKLDGLRGL 81
+NL+AG GGV HPLD VK+R P Y+G C +G+ GL
Sbjct: 12 KNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGL 71
Query: 82 YQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLCITNPL 141
Y+G+ I G + + FF + K + + + L + + +G T I P
Sbjct: 72 YRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLSGVFTTGIMTPG 131
Query: 142 WVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLF-GTSHGALQF 200
K L +Q +S +Y G D K+Y+ G+RG+YKG V L + F
Sbjct: 132 ERIKCLLQIQ----ASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYF 187
Query: 201 MAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARLQ--DQHMF 258
M YE LK + R+ E LS + ++ IF A P V+++R Q +
Sbjct: 188 MTYEWLKNIFTPEGKRVSE--LSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPGKY 245
Query: 259 YSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHFL 307
+G DV+ + R EGV YKG +IR PA F+ +E FL
Sbjct: 246 PNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKFL 294
Score = 43.5 bits (101), Expect = 2e-04
Identities = 25/83 (30%), Positives = 38/83 (45%), Gaps = 7/83 (8%)
Query: 222 LSTVEYISVAALSKIFAVAATYPYQVVRARLQDQHM-------FYSGVIDVITKTWRKEG 274
+S ++ + + V +P V+ RLQ Q YSG D KT +EG
Sbjct: 8 ISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREG 67
Query: 275 VGGFYKGIAPNLIRVTPACCITF 297
+ G Y+G+A +I VTP + F
Sbjct: 68 ITGLYRGMAAPIIGVTPMFAVCF 90
>gi|55749577 solute carrier family 25 (mitochondrial carrier;
adenine nucleotide translocator), member 4 [Homo
sapiens]
Length = 298
Score = 98.6 bits (244), Expect = 6e-21
Identities = 84/314 (26%), Positives = 140/314 (44%), Gaps = 33/314 (10%)
Query: 10 GSSAWSTVFRHVRYENLIAGVSGGVLSNLALHPLDLVKIRFAV---SDGLELRPKYNGIL 66
G AWS + ++ +AG +S A+ P++ VK+ V S + +Y GI+
Sbjct: 2 GDHAWSFL------KDFLAGGVAAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGII 55
Query: 67 HCLTTIWKLDGLRGLYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEY--- 123
C+ I K G ++G N+ + L F F + K G + Y
Sbjct: 56 DCVVRIPKEQGFLSFWRGNLANVIRYFPTQALNFAFKDKYKQLFLGGVDRHKQFWRYFAG 115
Query: 124 -LVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGL 182
L S AGA +LC PL +TRL D + R++ G+ D ++KI+K +G+RGL
Sbjct: 116 NLASGGAAGATSLCFVYPLDFARTRLAA--DVGKGAAQREFHGLGDCIIKIFKSDGLRGL 173
Query: 183 YKGFVPGLFGTS-HGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAA 241
Y+GF + G + A F Y+ K LP+ + + ++S + AVA
Sbjct: 174 YQGFNVSVQGIIIYRAAYFGVYDTAK-------GMLPDPKNVHI-FVSWMIAQSVTAVAG 225
Query: 242 --TYPYQVVRARLQDQH------MFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPAC 293
+YP+ VR R+ Q + Y+G +D K + EG F+KG N++R
Sbjct: 226 LVSYPFDTVRRRMMMQSGRKGADIMYTGTVDCWRKIAKDEGAKAFFKGAWSNVLRGMGGA 285
Query: 294 CITFVVYENVSHFL 307
+ V+Y+ + ++
Sbjct: 286 FV-LVLYDEIKKYV 298
Score = 43.5 bits (101), Expect = 2e-04
Identities = 42/189 (22%), Positives = 78/189 (41%), Gaps = 11/189 (5%)
Query: 130 AGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPG 189
A A++ P+ K L +Q+ + S +QYKG+ D +V+I K +G ++G +
Sbjct: 18 AAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVRIPKEQGFLSFWRGNLAN 77
Query: 190 L---FGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQ 246
+ F T AL F + K + ++R + ++ + ++ YP
Sbjct: 78 VIRYFPTQ--ALNFAFKDKYKQLFLGGVDRHKQFWRYFAGNLASGGAAGATSLCFVYPLD 135
Query: 247 VVRARLQDQ------HMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVY 300
R RL + G+ D I K ++ +G+ G Y+G ++ + F VY
Sbjct: 136 FARTRLAADVGKGAAQREFHGLGDCIIKIFKSDGLRGLYQGFNVSVQGIIIYRAAYFGVY 195
Query: 301 ENVSHFLLD 309
+ L D
Sbjct: 196 DTAKGMLPD 204
Score = 35.4 bits (80), Expect = 0.066
Identities = 25/93 (26%), Positives = 41/93 (44%), Gaps = 12/93 (12%)
Query: 231 AALSKIFAVAATYPYQVVRARLQDQHMF--------YSGVIDVITKTWRKEGVGGFYKGI 282
AA+SK A P + V+ LQ QH Y G+ID + + +++G F++G
Sbjct: 19 AAVSK----TAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVRIPKEQGFLSFWRGN 74
Query: 283 APNLIRVTPACCITFVVYENVSHFLLDLREKRK 315
N+IR P + F + L ++ K
Sbjct: 75 LANVIRYFPTQALNFAFKDKYKQLFLGGVDRHK 107
>gi|156071459 solute carrier family 25, member 5 [Homo sapiens]
Length = 298
Score = 98.6 bits (244), Expect = 6e-21
Identities = 86/299 (28%), Positives = 137/299 (45%), Gaps = 27/299 (9%)
Query: 24 ENLIAGVSGGVLSNLALHPLDLVKIRFAV---SDGLELRPKYNGILHCLTTIWKLDGLRG 80
++ +AG +S A+ P++ VK+ V S + +Y GI+ C+ I K G+
Sbjct: 10 KDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVLS 69
Query: 81 LYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEY----LVSAAEAGAMTLC 136
++G N+ + L F F + K G +R + Y L S AGA +LC
Sbjct: 70 FWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLASGGAAGATSLC 129
Query: 137 ITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFG-TSH 195
PL +TRL D R+++G+ D LVKIYK +G++GLY+GF + G +
Sbjct: 130 FVYPLDFARTRLAA--DVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFNVSVQGIIIY 187
Query: 196 GALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVA--ATYPYQVVRARLQ 253
A F Y+ K LP+ + +T IS + AVA +YP+ VR R+
Sbjct: 188 RAAYFGIYDTAK-------GMLPDPK-NTHIVISWMIAQTVTAVAGLTSYPFDTVRRRMM 239
Query: 254 DQ------HMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHF 306
Q + Y+G +D K R EG F+KG N++R + V+Y+ + +
Sbjct: 240 MQSGRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLRGMGGAFV-LVLYDEIKKY 297
Score = 38.9 bits (89), Expect = 0.006
Identities = 27/92 (29%), Positives = 42/92 (45%), Gaps = 12/92 (13%)
Query: 231 AALSKIFAVAATYPYQVVRARLQDQHMF--------YSGVIDVITKTWRKEGVGGFYKGI 282
AA+SK A P + V+ LQ QH Y G+ID + + +++GV F++G
Sbjct: 19 AAISK----TAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVLSFWRGN 74
Query: 283 APNLIRVTPACCITFVVYENVSHFLLDLREKR 314
N+IR P + F + L +KR
Sbjct: 75 LANVIRYFPTQALNFAFKDKYKQIFLGGVDKR 106
>gi|156071462 solute carrier family 25, member A6 [Homo sapiens]
Length = 298
Score = 98.2 bits (243), Expect = 8e-21
Identities = 82/281 (29%), Positives = 130/281 (46%), Gaps = 26/281 (9%)
Query: 24 ENLIAGVSGGVLSNLALHPLDLVKIRFAV---SDGLELRPKYNGILHCLTTIWKLDGLRG 80
++ +AG +S A+ P++ VK+ V S + +Y GI+ C+ I K G+
Sbjct: 10 KDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLS 69
Query: 81 LYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEY----LVSAAEAGAMTLC 136
++G N+ + L F F + K G + + Y L S AGA +LC
Sbjct: 70 FWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLC 129
Query: 137 ITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFG-TSH 195
PL +TRL D + R+++G+ D LVKI K +G+RGLY+GF + G +
Sbjct: 130 FVYPLDFARTRLAA--DVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIY 187
Query: 196 GALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVA--ATYPYQVVRARLQ 253
A F Y+ K LP+ + +T +S + AVA +YP+ VR R+
Sbjct: 188 RAAYFGVYDTAK-------GMLPDPK-NTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMM 239
Query: 254 DQ------HMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIR 288
Q + Y+G +D K +R EG F+KG N++R
Sbjct: 240 MQSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLR 280
Score = 67.4 bits (163), Expect = 2e-11
Identities = 49/184 (26%), Positives = 80/184 (43%), Gaps = 5/184 (2%)
Query: 25 NLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLE-LRPKYNGILHCLTTIWKLDGLRGLYQ 83
NL +G + G S ++PLD + R A G ++ G+ CL I K DG+RGLYQ
Sbjct: 116 NLASGGAAGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQ 175
Query: 84 GVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLCITNPLWV 143
G + ++ G + YF Y+ K + + + + + A A ++ P
Sbjct: 176 GFSVSVQGIIIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTAVAGV--VSYPFDT 233
Query: 144 TKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGTSHGALQFMAY 203
+ R+M+Q Y G D KI++ EG + +KG + GA + Y
Sbjct: 234 VRRRMMMQSGR--KGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVLY 291
Query: 204 ELLK 207
+ LK
Sbjct: 292 DELK 295
Score = 43.1 bits (100), Expect = 3e-04
Identities = 40/189 (21%), Positives = 79/189 (41%), Gaps = 11/189 (5%)
Query: 130 AGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPG 189
A A++ P+ K L +Q+ + + +QYKG+ D +V+I K +GV ++G +
Sbjct: 18 AAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLSFWRGNLAN 77
Query: 190 L---FGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQ 246
+ F T AL F + K + +++ + ++ + ++ YP
Sbjct: 78 VIRYFPTQ--ALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLCFVYPLD 135
Query: 247 VVRARL------QDQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVY 300
R RL + G+ D + K + +G+ G Y+G + ++ + F VY
Sbjct: 136 FARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRAAYFGVY 195
Query: 301 ENVSHFLLD 309
+ L D
Sbjct: 196 DTAKGMLPD 204
>gi|13775208 solute carrier family 25 (mitochondrial carrier;
adenine nucleotide translocator), member 31 [Homo
sapiens]
Length = 315
Score = 97.4 bits (241), Expect = 1e-20
Identities = 79/296 (26%), Positives = 137/296 (46%), Gaps = 23/296 (7%)
Query: 24 ENLIAGVSGGVLSNLALHPLDLVKIRFAV---SDGLELRPKYNGILHCLTTIWKLDGLRG 80
++L+AG +S A+ P++ VK+ V S + +Y G++ CL I + G
Sbjct: 22 KDLLAGGVAAAVSKTAVAPIERVKLLLQVQASSKQISPEARYKGMVDCLVRIPREQGFFS 81
Query: 81 LYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEY----LVSAAEAGAMTLC 136
++G N+ + L F F + K G + + + L S AGA +LC
Sbjct: 82 FWRGNLANVIRYFPTQALNFAFKDKYKQLFMSGVNKEKQFWRWFLANLASGGAAGATSLC 141
Query: 137 ITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGTS-H 195
+ PL +TRL + D RQ+KG+ D ++KI K +G+ GLY+GF + G +
Sbjct: 142 VVYPLDFARTRLGV--DIGKGPEERQFKGLGDCIMKIAKSDGIAGLYQGFGVSVQGIIVY 199
Query: 196 GALQFMAYELLKLKYNQHINRLPEAQLST-VEYISVAALSKIFAVAATYPYQVVRARLQD 254
A F AY+ +K LP+ + + + +A + + +YP+ VR R+
Sbjct: 200 RASYFGAYDTVK-------GLLPKPKKTPFLVSFFIAQVVTTCSGILSYPFDTVRRRMMM 252
Query: 255 QH----MFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHF 306
Q Y G +D K ++ EG+ F++G N++R T + V+Y+ + F
Sbjct: 253 QSGEAKRQYKGTLDCFVKIYQHEGISSFFRGAFSNVLRGTGG-ALVLVLYDKIKEF 307
Score = 49.3 bits (116), Expect = 4e-06
Identities = 43/193 (22%), Positives = 80/193 (41%), Gaps = 11/193 (5%)
Query: 124 LVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLY 183
L++ A A++ P+ K L +Q + SP +YKGM D LV+I + +G +
Sbjct: 24 LLAGGVAAAVSKTAVAPIERVKLLLQVQASSKQISPEARYKGMVDCLVRIPREQGFFSFW 83
Query: 184 KGFVPGL---FGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVA 240
+G + + F T AL F + K + +N+ + + ++ + ++
Sbjct: 84 RGNLANVIRYFPTQ--ALNFAFKDKYKQLFMSGVNKEKQFWRWFLANLASGGAAGATSLC 141
Query: 241 ATYPYQVVRARL------QDQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACC 294
YP R RL + + G+ D I K + +G+ G Y+G ++ +
Sbjct: 142 VVYPLDFARTRLGVDIGKGPEERQFKGLGDCIMKIAKSDGIAGLYQGFGVSVQGIIVYRA 201
Query: 295 ITFVVYENVSHFL 307
F Y+ V L
Sbjct: 202 SYFGAYDTVKGLL 214
Score = 32.0 bits (71), Expect = 0.73
Identities = 24/93 (25%), Positives = 39/93 (41%), Gaps = 12/93 (12%)
Query: 231 AALSKIFAVAATYPYQVVRARLQDQ--------HMFYSGVIDVITKTWRKEGVGGFYKGI 282
AA+SK A P + V+ LQ Q Y G++D + + R++G F++G
Sbjct: 31 AAVSK----TAVAPIERVKLLLQVQASSKQISPEARYKGMVDCLVRIPREQGFFSFWRGN 86
Query: 283 APNLIRVTPACCITFVVYENVSHFLLDLREKRK 315
N+IR P + F + + K K
Sbjct: 87 LANVIRYFPTQALNFAFKDKYKQLFMSGVNKEK 119
>gi|149274607 solute carrier family 25, member 41 [Homo sapiens]
Length = 370
Score = 96.7 bits (239), Expect = 2e-20
Identities = 76/280 (27%), Positives = 131/280 (46%), Gaps = 17/280 (6%)
Query: 26 LIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLYQGV 85
L++G G +S PLD K+ V + + +L L ++ + G R L++G
Sbjct: 96 LLSGAMAGAVSRTGTAPLDRAKVYMQVYSS---KTNFTNLLGGLQSMVQEGGFRSLWRGN 152
Query: 86 TPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLCITNPLWVTK 145
N+ + + F + K+Y G E L++ + A A++ + NP+ V K
Sbjct: 153 GINVLKIAPEYAIKFSVFEQCKNYFC-GIQGSPPFQERLLAGSLAVAISQTLINPMEVLK 211
Query: 146 TRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGT-SHGALQFMAYE 204
TRL L+ QYKG+ D +I + EG R LY+G++P + G + YE
Sbjct: 212 TRLTLRRTG-------QYKGLLDCARQILQREGTRALYRGYLPNMLGIIPYACTDLAVYE 264
Query: 205 LLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARLQDQHMFYSG--- 261
+L+ + + + + S + +S LS A+YP +VR R+Q Q
Sbjct: 265 MLQCFWVKSGRDMGDP--SGLVSLSSVTLSTTCGQMASYPLTLVRTRMQAQDTVEGSNPT 322
Query: 262 VIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYE 301
+ V+ + ++G G Y+G+ P L++V PA I++VVYE
Sbjct: 323 MRGVLQRILAQQGWLGLYRGMTPTLLKVLPAGGISYVVYE 362
Score = 57.8 bits (138), Expect = 1e-08
Identities = 48/188 (25%), Positives = 83/188 (44%), Gaps = 14/188 (7%)
Query: 24 ENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLYQ 83
E L+AG +S ++P++++K R L +Y G+L C I + +G R LY+
Sbjct: 188 ERLLAGSLAVAISQTLINPMEVLKTRLT----LRRTGQYKGLLDCARQILQREGTRALYR 243
Query: 84 GVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLC---ITNP 140
G PN+ G Y ++ + + + + + LVS + T C + P
Sbjct: 244 GYLPNMLGIIPYACTDLAVYEMLQCFWVKSGRDMGDPSG-LVSLSSVTLSTTCGQMASYP 302
Query: 141 LWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGT-SHGALQ 199
L + +TR+ Q ++P M L +I +G GLY+G P L G +
Sbjct: 303 LTLVRTRMQAQDTVEGSNP-----TMRGVLQRILAQQGWLGLYRGMTPTLLKVLPAGGIS 357
Query: 200 FMAYELLK 207
++ YE +K
Sbjct: 358 YVVYEAMK 365
Score = 50.8 bits (120), Expect = 2e-06
Identities = 47/187 (25%), Positives = 84/187 (44%), Gaps = 13/187 (6%)
Query: 122 EYLVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRG 181
++L+S A AGA++ T PL + ++ +Q V S + + L + + G R
Sbjct: 94 KFLLSGAMAGAVSRTGTAPL--DRAKVYMQ----VYSSKTNFTNLLGGLQSMVQEGGFRS 147
Query: 182 LYKGF-VPGLFGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVA 240
L++G + L A++F +E K Y I P Q E + +L+ +
Sbjct: 148 LWRGNGINVLKIAPEYAIKFSVFEQCK-NYFCGIQGSPPFQ----ERLLAGSLAVAISQT 202
Query: 241 ATYPYQVVRARLQDQHMF-YSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVV 299
P +V++ RL + Y G++D + ++EG Y+G PN++ + P C V
Sbjct: 203 LINPMEVLKTRLTLRRTGQYKGLLDCARQILQREGTRALYRGYLPNMLGIIPYACTDLAV 262
Query: 300 YENVSHF 306
YE + F
Sbjct: 263 YEMLQCF 269
>gi|116235462 solute carrier family 25, member 45 isoform a [Homo
sapiens]
Length = 288
Score = 95.5 bits (236), Expect = 5e-20
Identities = 78/290 (26%), Positives = 132/290 (45%), Gaps = 24/290 (8%)
Query: 24 ENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLYQ 83
E +AG G L + HP D VK+R L+ + Y GI+ C+ I++ + L G ++
Sbjct: 4 EEFVAGWISGALGLVLGHPFDTVKVR------LQTQTTYRGIVDCMVKIYRHESLLGFFK 57
Query: 84 GVTPNIWGAGLSWGLYFFFYNAIKSYKT-----EGRAERLEATEYLVSAAEAGAMTLCIT 138
G++ I + + F Y+ T E RA+ ++ G +
Sbjct: 58 GMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCL 117
Query: 139 NPLWVTKTRLMLQYD--AVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKG-FVPGLFGTSH 195
P + K RL Q + A SP +Y+G I++ EG RGL++G + L T
Sbjct: 118 APFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPT 177
Query: 196 GALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAA-LSKIFAVAATYPYQVVRARLQD 254
+ F+ YE L +Y PE Q + + VA + I + A P ++++R+Q
Sbjct: 178 VGIYFITYEGLCRQYT------PEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQM 231
Query: 255 QHM---FYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYE 301
+ Y G++D + + R+EG+G F++G+ N R P +TF+ YE
Sbjct: 232 DGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYE 281
Score = 58.2 bits (139), Expect = 1e-08
Identities = 51/196 (26%), Positives = 84/196 (42%), Gaps = 25/196 (12%)
Query: 122 EYLVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRG 181
E V+ +GA+ L + +P K RL Q Y+G+ D +VKIY++E + G
Sbjct: 4 EEFVAGWISGALGLVLGHPFDTVKVRLQTQ---------TTYRGIVDCMVKIYRHESLLG 54
Query: 182 LYKGF---VPGLFGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFA 238
+KG + + + + LL L H R AQ + +I +A + F
Sbjct: 55 FFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQER--RAQPPSYMHIFLAGCTGGFL 112
Query: 239 VA-ATYPYQVVRARLQDQHM----------FYSGVIDVITKTWRKEGVGGFYKGIAPNLI 287
A P+ +++ RLQ+Q Y G + +R+EG G ++G +
Sbjct: 113 QAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTL 172
Query: 288 RVTPACCITFVVYENV 303
R TP I F+ YE +
Sbjct: 173 RDTPTVGIYFITYEGL 188
Score = 43.5 bits (101), Expect = 2e-04
Identities = 23/78 (29%), Positives = 39/78 (50%), Gaps = 1/78 (1%)
Query: 225 VEYISVAALSKIFAVAATYPYQVVRARLQDQHMFYSGVIDVITKTWRKEGVGGFYKGIAP 284
VE +S + +P+ V+ RLQ Q Y G++D + K +R E + GF+KG++
Sbjct: 3 VEEFVAGWISGALGLVLGHPFDTVKVRLQTQTT-YRGIVDCMVKIYRHESLLGFFKGMSF 61
Query: 285 NLIRVTPACCITFVVYEN 302
+ + + F VY N
Sbjct: 62 PIASIAVVNSVLFGVYSN 79
>gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Homo
sapiens]
Length = 325
Score = 94.7 bits (234), Expect = 9e-20
Identities = 91/312 (29%), Positives = 131/312 (41%), Gaps = 32/312 (10%)
Query: 9 SGSSAWSTVFRHVRYENLIAGVSGGVLSNLA---LHPLDLVKIRFAVS----DGLELRPK 61
SG +TV + N V GG+ S +A P+DL K R V D K
Sbjct: 24 SGHQKSTTVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIK 83
Query: 62 YNGILHCLTTIWKLDGLRGLYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEAT 121
Y G+ H L I K +G+ LY G+ P + + Y ++K E RLE
Sbjct: 84 YRGMFHALFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVE----RLEDE 139
Query: 122 EYLVS---AAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEG 178
L++ +G ++ I NP V K R+ Q S M + + IY+ EG
Sbjct: 140 TLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGS-------MIGSFIDIYQQEG 192
Query: 179 VRGLYKGFVPGLFGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFA 238
RGL++G VP T+ A + EL + L T+ V++ + A
Sbjct: 193 TRGLWRGVVP----TAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLA 248
Query: 239 VA-ATYPYQVVRARLQDQHMF------YSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTP 291
A A+ P VVR R+ +Q Y G +D I K W+ EG YKG PN +R+ P
Sbjct: 249 GALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGP 308
Query: 292 ACCITFVVYENV 303
I F+ YE +
Sbjct: 309 WNIIFFITYEQL 320
Score = 65.9 bits (159), Expect = 5e-11
Identities = 49/174 (28%), Positives = 81/174 (46%), Gaps = 8/174 (4%)
Query: 138 TNPLWVTKTRLMLQYDAV-VNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFG-TSH 195
T P+ +TKTRL +Q ++ +Y+GMF L +I K EGV LY G P L S+
Sbjct: 58 TFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASY 117
Query: 196 GALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARLQDQ 255
G ++ Y+ LK + + RL + L V +S + + P V++ R+Q Q
Sbjct: 118 GTIKIGIYQSLKRLF---VERLEDETLLINMICGV--VSGVISSTIANPTDVLKIRMQAQ 172
Query: 256 HMFYSG-VIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHFLL 308
+ G +I +++EG G ++G+ P R + VY+ L+
Sbjct: 173 GSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLI 226
Score = 39.3 bits (90), Expect = 0.005
Identities = 24/89 (26%), Positives = 41/89 (46%), Gaps = 9/89 (10%)
Query: 233 LSKIFAVAATYPYQVVRARLQDQ---------HMFYSGVIDVITKTWRKEGVGGFYKGIA 283
L+ I A T+P + + RLQ Q + Y G+ + + ++EGV Y GIA
Sbjct: 49 LASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSGIA 108
Query: 284 PNLIRVTPACCITFVVYENVSHFLLDLRE 312
P L+R I +Y+++ ++ E
Sbjct: 109 PALLRQASYGTIKIGIYQSLKRLFVERLE 137
>gi|13259543 solute carrier family 25, member 14 isoform UCP5S [Homo
sapiens]
Length = 322
Score = 94.4 bits (233), Expect = 1e-19
Identities = 82/297 (27%), Positives = 125/297 (42%), Gaps = 29/297 (9%)
Query: 21 VRYENLIAGVSGGVLSNLALHPLDLVKIRFAVS----DGLELRPKYNGILHCLTTIWKLD 76
+ ++ + G +++ P+DL K R V D KY G+ H L I K +
Sbjct: 36 LNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEE 95
Query: 77 GLRGLYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVS---AAEAGAM 133
G+ LY G+ P + + Y ++K E RLE L++ +G +
Sbjct: 96 GVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVE----RLEDETLLINMICGVVSGVI 151
Query: 134 TLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGT 193
+ I NP V K R+ Q S M + + IY+ EG RGL++G VP T
Sbjct: 152 SSTIANPTDVLKIRMQAQGSLFQGS-------MIGSFIDIYQQEGTRGLWRGVVP----T 200
Query: 194 SHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVA-ATYPYQVVRARL 252
+ A + EL + L T+ V++ + A A A+ P VVR R+
Sbjct: 201 AQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRM 260
Query: 253 QDQHMF------YSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENV 303
+Q Y G +D I K W+ EG YKG PN +R+ P I F+ YE +
Sbjct: 261 MNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQL 317
Score = 65.9 bits (159), Expect = 5e-11
Identities = 49/174 (28%), Positives = 81/174 (46%), Gaps = 8/174 (4%)
Query: 138 TNPLWVTKTRLMLQYDAV-VNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFG-TSH 195
T P+ +TKTRL +Q ++ +Y+GMF L +I K EGV LY G P L S+
Sbjct: 55 TFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASY 114
Query: 196 GALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARLQDQ 255
G ++ Y+ LK + + RL + L V +S + + P V++ R+Q Q
Sbjct: 115 GTIKIGIYQSLKRLF---VERLEDETLLINMICGV--VSGVISSTIANPTDVLKIRMQAQ 169
Query: 256 HMFYSG-VIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHFLL 308
+ G +I +++EG G ++G+ P R + VY+ L+
Sbjct: 170 GSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLI 223
Score = 39.3 bits (90), Expect = 0.005
Identities = 24/89 (26%), Positives = 41/89 (46%), Gaps = 9/89 (10%)
Query: 233 LSKIFAVAATYPYQVVRARLQDQ---------HMFYSGVIDVITKTWRKEGVGGFYKGIA 283
L+ I A T+P + + RLQ Q + Y G+ + + ++EGV Y GIA
Sbjct: 46 LASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSGIA 105
Query: 284 PNLIRVTPACCITFVVYENVSHFLLDLRE 312
P L+R I +Y+++ ++ E
Sbjct: 106 PALLRQASYGTIKIGIYQSLKRLFVERLE 134
>gi|46409330 solute carrier family 25, member 34 [Homo sapiens]
Length = 304
Score = 93.6 bits (231), Expect = 2e-19
Identities = 76/291 (26%), Positives = 140/291 (48%), Gaps = 19/291 (6%)
Query: 25 NLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELR---PK-YNGILHCLTTIWKLDGLRG 80
+L+ G S L+ + +PL++VK R + L+ R P+ Y+G + + + + DGL G
Sbjct: 9 DLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADGLWG 68
Query: 81 LYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLCITNP 140
L +G+ + GL G+ F+ Y+ G ++ T +V+ A AGA+ + +P
Sbjct: 69 LQKGLAAGLLYQGLMNGVRFYCYSLACQ---AGLTQQPGGT--VVAGAVAGALGAFVGSP 123
Query: 141 LWVTKTRLMLQYDAVVNSPHRQ-YKGMFDTLVKIYKYEGVRGLYKGFVPGLFGTSHGALQ 199
++ KT+L Q A V H+ ++ + L I++ +G+ GL++G + G+
Sbjct: 124 AYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVGSAA 183
Query: 200 FMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARLQDQHM-- 257
+A + Q LPE S + ++ +S I V P+ VV RL +Q +
Sbjct: 184 QLATFASAKAWVQKQQWLPED--SWLVALAGGMISSIAVVVVMTPFDVVSTRLYNQPVDT 241
Query: 258 -----FYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENV 303
Y G+ D + K WR+EG YKG+ P +R+ P ++ + ++ +
Sbjct: 242 AGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDEL 292
Score = 40.4 bits (93), Expect = 0.002
Identities = 28/114 (24%), Positives = 54/114 (47%), Gaps = 8/114 (7%)
Query: 9 SGSSAWSTVFRHVRYENLIAGVSGGVLSNLA----LHPLDLVKIRFAVS--DGLELRPKY 62
+ + AW + + ++ + ++GG++S++A + P D+V R D Y
Sbjct: 189 ASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTRLYNQPVDTAGRGQLY 248
Query: 63 NGILHCLTTIWKLDGLRGLYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAE 116
G+ C+ IW+ +G LY+G+ P G L F++ ++ K GRA+
Sbjct: 249 GGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELR--KLAGRAQ 300
>gi|58197562 solute carrier family 25, member 30 [Homo sapiens]
Length = 291
Score = 93.2 bits (230), Expect = 3e-19
Identities = 78/295 (26%), Positives = 128/295 (43%), Gaps = 24/295 (8%)
Query: 21 VRYENLIAGVSGGVLSNLALHPLDLVKIRFAV----SDGLELRPKYNGILHCLTTIWKLD 76
+ ++ + G + + P+DL K R + +D +Y G+LH L I + +
Sbjct: 4 LNWKPFVYGGLASITAECGTFPIDLTKTRLQIQGQTNDAKFKEIRYRGMLHALVRIGREE 63
Query: 77 GLRGLYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLC 136
GL+ LY G+ P + + Y ++K E R E ++ +G ++
Sbjct: 64 GLKALYSGIAPAMLRQASYGTIKIGTYQSLKRLFIE-RPEDETLPINVICGILSGVISST 122
Query: 137 ITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGTSHG 196
I NP V K R+ Q + + GM + IY+ EG RGL+KG + T+
Sbjct: 123 IANPTDVLKIRMQAQSNTIQG-------GMIGNFMNIYQQEGTRGLWKG----VSLTAQR 171
Query: 197 ALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVA-ATYPYQVVRARLQDQ 255
A + EL + L TV +++ + A A A+ P VVR R+ +Q
Sbjct: 172 AAIVVGVELPVYDITKKHLILSGLMGDTVYTHFLSSFTCGLAGALASNPVDVVRTRMMNQ 231
Query: 256 HMF-------YSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENV 303
+ Y+G +D + +TW+ EG YKG PN +R+ P I FV YE +
Sbjct: 232 RVLRDGRCSGYTGTLDCLLQTWKNEGFFALYKGFWPNWLRLGPWNIIFFVTYEQL 286
Score = 63.2 bits (152), Expect = 3e-10
Identities = 47/176 (26%), Positives = 81/176 (46%), Gaps = 8/176 (4%)
Query: 136 CITNPLWVTKTRLMLQYDAV-VNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFG-T 193
C T P+ +TKTRL +Q +Y+GM LV+I + EG++ LY G P +
Sbjct: 21 CGTFPIDLTKTRLQIQGQTNDAKFKEIRYRGMLHALVRIGREEGLKALYSGIAPAMLRQA 80
Query: 194 SHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARLQ 253
S+G ++ Y+ LK + + PE + + I LS + + P V++ R+Q
Sbjct: 81 SYGTIKIGTYQSLKRLFIER----PEDETLPINVIC-GILSGVISSTIANPTDVLKIRMQ 135
Query: 254 DQ-HMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHFLL 308
Q + G+I +++EG G +KG++ R + VY+ L+
Sbjct: 136 AQSNTIQGGMIGNFMNIYQQEGTRGLWKGVSLTAQRAAIVVGVELPVYDITKKHLI 191
Score = 40.4 bits (93), Expect = 0.002
Identities = 23/89 (25%), Positives = 41/89 (46%), Gaps = 9/89 (10%)
Query: 233 LSKIFAVAATYPYQVVRARLQDQ---------HMFYSGVIDVITKTWRKEGVGGFYKGIA 283
L+ I A T+P + + RLQ Q + Y G++ + + R+EG+ Y GIA
Sbjct: 14 LASITAECGTFPIDLTKTRLQIQGQTNDAKFKEIRYRGMLHALVRIGREEGLKALYSGIA 73
Query: 284 PNLIRVTPACCITFVVYENVSHFLLDLRE 312
P ++R I Y+++ ++ E
Sbjct: 74 PAMLRQASYGTIKIGTYQSLKRLFIERPE 102
>gi|82775373 solute carrier family 25, member 37 [Homo sapiens]
Length = 338
Score = 90.5 bits (223), Expect = 2e-18
Identities = 81/320 (25%), Positives = 135/320 (42%), Gaps = 32/320 (10%)
Query: 3 GQGQSASGSSAWSTVFRHVRYE-NLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPK 61
G G+ A+GS + + ++ AG G+L + ++P+D VK R S + + +
Sbjct: 25 GGGKDATGSEDYENLPTSASVSTHMTAGAMAGILEHSVMYPVDSVKTRMQ-SLSPDPKAQ 83
Query: 62 YNGILHCLTTIWKLDGLRGLYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEAT 121
Y I L I + +G +GV I GAG + +YF Y +K +T +
Sbjct: 84 YTSIYGALKKIMRTEGFWRPLRGVNVMIMGAGPAHAMYFACYENMK--RTLNDVFHHQGN 141
Query: 122 EYLVSAAEAGAMTL---CITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEG 178
+L + TL + NP V K RL + NS HR T +++ EG
Sbjct: 142 SHLANGIAGSMATLLHDAVMNPAEVVKQRLQMY-----NSQHRSAISCIRT---VWRTEG 193
Query: 179 VRGLYKGFVPGL-FGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIF 237
+ Y+ + L ++ F+ YE L+ + N H P++ +I L+
Sbjct: 194 LGAFYRSYTTQLTMNIPFQSIHFITYEFLQEQVNPHRTYNPQS------HIISGGLAGAL 247
Query: 238 AVAATYPYQVVRARLQDQHMF----------YSGVIDVITKTWRKEGVGGFYKGIAPNLI 287
A AAT P V + L Q SG+ + ++ G+ G++KGI +I
Sbjct: 248 AAAATTPLDVCKTLLNTQENVALSLANISGRLSGMANAFRTVYQLNGLAGYFKGIQARVI 307
Query: 288 RVTPACCITFVVYENVSHFL 307
P+ I++ VYE +FL
Sbjct: 308 YQMPSTAISWSVYEFFKYFL 327
Score = 36.6 bits (83), Expect = 0.030
Identities = 23/92 (25%), Positives = 41/92 (44%), Gaps = 4/92 (4%)
Query: 223 STVEYISVAALSKIFAVAATYPYQVVRARLQ----DQHMFYSGVIDVITKTWRKEGVGGF 278
S +++ A++ I + YP V+ R+Q D Y+ + + K R EG
Sbjct: 44 SVSTHMTAGAMAGILEHSVMYPVDSVKTRMQSLSPDPKAQYTSIYGALKKIMRTEGFWRP 103
Query: 279 YKGIAPNLIRVTPACCITFVVYENVSHFLLDL 310
+G+ ++ PA + F YEN+ L D+
Sbjct: 104 LRGVNVMIMGAGPAHAMYFACYENMKRTLNDV 135
>gi|21389315 solute carrier family 25 (mitochondrial carrier;
citrate transporter), member 1 precursor [Homo sapiens]
Length = 311
Score = 88.2 bits (217), Expect = 9e-18
Identities = 75/289 (25%), Positives = 134/289 (46%), Gaps = 21/289 (7%)
Query: 26 LIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLYQGV 85
L G++GG+ + P + VK + + D P+Y GI C+ + G+ GLY+G+
Sbjct: 30 LAGGLAGGIEICITF-PTEYVKTQLQL-DERSHPPRYRGIGDCVRQTVRSHGVLGLYRGL 87
Query: 86 TPNIWG----AGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAG-AMTLCITNP 140
+ ++G A + +G++ F N ++ + RL++T L+ AG A + + P
Sbjct: 88 SSLLYGSIPKAAVRFGMFEFLSNHMRDAQG-----RLDSTRGLLCGLGAGVAEAVVVVCP 142
Query: 141 LWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGT-SHGALQ 199
+ K + + SP+ +Y+G F + +I + +G++G Y+G + S+ A++
Sbjct: 143 METIKVKFIHDQ----TSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIR 198
Query: 200 FMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARLQDQHMF- 258
F L+ Y P L T + ++A + +F P V++ R+Q
Sbjct: 199 FFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFG---NTPLDVIKTRMQGLEAHK 255
Query: 259 YSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHFL 307
Y D + +KEG+ FYKG P L RV I FV+Y+ V L
Sbjct: 256 YRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLL 304
Score = 52.4 bits (124), Expect = 5e-07
Identities = 47/199 (23%), Positives = 89/199 (44%), Gaps = 13/199 (6%)
Query: 113 GRAERLEATEYLVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVK 172
G+A+ + +++ AG + +CIT P KT+L L S +Y+G+ D + +
Sbjct: 18 GKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLD----ERSHPPRYRGIGDCVRQ 73
Query: 173 IYKYEGVRGLYKGFVPGLFGT-SHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVA 231
+ GV GLY+G L+G+ A++F +E L RL ST +
Sbjct: 74 TVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLD----STRGLLCGL 129
Query: 232 ALSKIFAVAATYPYQVVRAR-LQDQ---HMFYSGVIDVITKTWRKEGVGGFYKGIAPNLI 287
AV P + ++ + + DQ + Y G + + R++G+ G Y+G+ ++
Sbjct: 130 GAGVAEAVVVVCPMETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVL 189
Query: 288 RVTPACCITFVVYENVSHF 306
+ I F V ++ ++
Sbjct: 190 KQGSNQAIRFFVMTSLRNW 208
Score = 39.3 bits (90), Expect = 0.005
Identities = 22/75 (29%), Positives = 40/75 (53%), Gaps = 4/75 (5%)
Query: 239 VAATYPYQVVRARLQ-DQHMF---YSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACC 294
+ T+P + V+ +LQ D+ Y G+ D + +T R GV G Y+G++ L P
Sbjct: 40 ICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAA 99
Query: 295 ITFVVYENVSHFLLD 309
+ F ++E +S+ + D
Sbjct: 100 VRFGMFEFLSNHMRD 114
>gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens]
Length = 308
Score = 86.3 bits (212), Expect = 3e-17
Identities = 74/308 (24%), Positives = 127/308 (41%), Gaps = 39/308 (12%)
Query: 25 NLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLYQG 84
+ +AG GGV +PLD VK+R ++ PKY GI HC+ + + + G Y+G
Sbjct: 2 DFVAGAIGGVCGVAVGYPLDTVKVR------IQTEPKYTGIWHCVRDTYHRERVWGFYRG 55
Query: 85 VTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEA----TEYLVSAAEAGAMTLCITNP 140
++ + L + F Y ++ R +A + +S +G + + +T+P
Sbjct: 56 LSLPVCTVSLVSSVSFGTYRHCLAHICRLRYGNPDAKPTKADITLSGCASGLVRVFLTSP 115
Query: 141 LWVTKTRLMLQYDAVVNS---------------------PHRQYKGMFDTLVKIYKYEGV 179
V K RL Q A P +Y+G L + + EG+
Sbjct: 116 TEVAKVRLQTQTQAQKQQRRLSASGPLAVPPMCPVPPACPEPKYRGPLHCLATVAREEGL 175
Query: 180 RGLYKGFVPGLFGTSHG-ALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFA 238
GLYKG + H A F++Y +L + ++ ++ + + + A
Sbjct: 176 CGLYKGSSALVLRDGHSFATYFLSYAVLC----EWLSPAGHSRPDVPGVLVAGGCAGVLA 231
Query: 239 VAATYPYQVVRARLQDQ---HMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCI 295
A P V+++RLQ Y G++ + + R+EG +KG+ N R P +
Sbjct: 232 WAVATPMDVIKSRLQADGQGQRRYRGLLHCMVTSVREEGPRVLFKGLVLNCCRAFPVNMV 291
Query: 296 TFVVYENV 303
FV YE V
Sbjct: 292 VFVAYEAV 299
Score = 41.6 bits (96), Expect = 0.001
Identities = 22/80 (27%), Positives = 41/80 (51%), Gaps = 1/80 (1%)
Query: 232 ALSKIFAVAATYPYQVVRARLQDQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTP 291
A+ + VA YP V+ R+Q + Y+G+ + T+ +E V GFY+G++ + V+
Sbjct: 7 AIGGVCGVAVGYPLDTVKVRIQTEPK-YTGIWHCVRDTYHRERVWGFYRGLSLPVCTVSL 65
Query: 292 ACCITFVVYENVSHFLLDLR 311
++F Y + + LR
Sbjct: 66 VSSVSFGTYRHCLAHICRLR 85
>gi|157388925 solute carrier family 25, member 38 [Homo sapiens]
Length = 304
Score = 85.9 bits (211), Expect = 4e-17
Identities = 71/292 (24%), Positives = 125/292 (42%), Gaps = 20/292 (6%)
Query: 16 TVFRHVRYENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKL 75
T+ H + + G G S L PLDL+K R + + G+L L + +
Sbjct: 21 TLMLHPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVRT 80
Query: 76 DGLRGLYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTL 135
+ L GL++G++P+I G+YF ++K Y G A E ++ + ++
Sbjct: 81 ESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPP--TALESVMLGVGSRSVAG 138
Query: 136 CITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGTSH 195
+P+ V KTR S Y+ ++ L IY EG RGL+ G L +
Sbjct: 139 VCMSPITVIKTR--------YESGKYGYESIYAALRSIYHSEGHRGLFSGLTATLLRDAP 190
Query: 196 GALQFMAYELLKLKYNQHINRLP----EAQLSTVEYISVAALSKIFAVAATYPYQVVRAR 251
+ ++ + YNQ N +P +A L + S + I A T P V++
Sbjct: 191 FSGIYLMF------YNQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTH 244
Query: 252 LQDQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENV 303
+Q + + + +T ++ G+ GF++G P +R T + + VYE +
Sbjct: 245 MQLYPLKFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYEEM 296
Score = 45.4 bits (106), Expect = 6e-05
Identities = 41/179 (22%), Positives = 70/179 (39%), Gaps = 10/179 (5%)
Query: 130 AGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYK-GMFDTLVKIYKYEGVRGLYKGFVP 188
+G + + PL + KTRL + S H + GM L+K+ + E + GL+KG P
Sbjct: 37 SGTCSTLLFQPLDLLKTRLQ----TLQPSDHGSRRVGMLAVLLKVVRTESLLGLWKGMSP 92
Query: 189 GLFGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVV 248
+ G + L LK P A +E + + S+ A P V+
Sbjct: 93 SIVRCVPGVGIYFG-TLYSLKQYFLRGHPPTA----LESVMLGVGSRSVAGVCMSPITVI 147
Query: 249 RARLQDQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHFL 307
+ R + Y + + + EG G + G+ L+R P I + Y + +
Sbjct: 148 KTRYESGKYGYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFYNQTKNIV 206
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,079,530
Number of Sequences: 37866
Number of extensions: 439401
Number of successful extensions: 1314
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 69
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 700
Number of HSP's gapped (non-prelim): 215
length of query: 315
length of database: 18,247,518
effective HSP length: 102
effective length of query: 213
effective length of database: 14,385,186
effective search space: 3064044618
effective search space used: 3064044618
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.