Guide to the Human Genome
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Search of human proteins with 209862994

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|209862994 MAP-kinase activating death domain-containing
protein isoform d [Homo sapiens]
         (1647 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|209862994 MAP-kinase activating death domain-containing prote...  3283   0.0  
gi|209862983 MAP-kinase activating death domain-containing prote...  3171   0.0  
gi|18860873 MAP-kinase activating death domain-containing protei...  3136   0.0  
gi|209862971 MAP-kinase activating death domain-containing prote...  3120   0.0  
gi|209571517 MAP-kinase activating death domain-containing prote...  3114   0.0  
gi|209862975 MAP-kinase activating death domain-containing prote...  3065   0.0  
gi|209862979 MAP-kinase activating death domain-containing prote...  3007   0.0  
gi|209862998 MAP-kinase activating death domain-containing prote...  3001   0.0  
gi|209863002 MAP-kinase activating death domain-containing prote...  2994   0.0  
gi|209862987 MAP-kinase activating death domain-containing prote...  2860   0.0  
gi|239735519 SET binding factor 1 [Homo sapiens]                      103   1e-21
gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapi...    90   2e-17
gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapi...    90   2e-17
gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]             84   1e-15
gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]              77   1e-13
gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]             77   1e-13
gi|29788755 SET binding factor 2 [Homo sapiens]                        77   2e-13
gi|44889475 RAB6 interacting protein 1 [Homo sapiens]                  72   3e-12
gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]               72   3e-12
gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapi...    62   6e-09
gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapi...    62   6e-09
gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo sapi...    62   6e-09
gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]             59   5e-08
gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]             58   7e-08
gi|113205087 DENN/MADD domain containing 1C [Homo sapiens]             58   7e-08
gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo sapi...    56   3e-07
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    55   6e-07
gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo sapi...    52   4e-06
gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]              51   8e-06
gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens]    49   4e-05

>gi|209862994 MAP-kinase activating death domain-containing protein
            isoform d [Homo sapiens]
          Length = 1647

 Score = 3283 bits (8513), Expect = 0.0
 Identities = 1647/1647 (100%), Positives = 1647/1647 (100%)

Query: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
            MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60

Query: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
            CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120

Query: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
            GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180

Query: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
            SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240

Query: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
            LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300

Query: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
            LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360

Query: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
            ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420

Query: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
            SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480

Query: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
            DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540

Query: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
            KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600

Query: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
            LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660

Query: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
            THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720

Query: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
            PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP
Sbjct: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780

Query: 781  PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
            PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 781  PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840

Query: 841  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900
            EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP
Sbjct: 841  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900

Query: 901  GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960
            GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW
Sbjct: 901  GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960

Query: 961  LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020
            LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL
Sbjct: 961  LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020

Query: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080
            SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP
Sbjct: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080

Query: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP 1140
            KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP
Sbjct: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP 1140

Query: 1141 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1200
            EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV
Sbjct: 1141 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1200

Query: 1201 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1260
            VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK
Sbjct: 1201 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1260

Query: 1261 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ 1320
            PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ
Sbjct: 1261 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ 1320

Query: 1321 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1380
            MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS
Sbjct: 1321 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1380

Query: 1381 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1440
            YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK
Sbjct: 1381 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1440

Query: 1441 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1500
            QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR
Sbjct: 1441 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1500

Query: 1501 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1560
            NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ
Sbjct: 1501 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1560

Query: 1561 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1620
            VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS
Sbjct: 1561 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1620

Query: 1621 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1647
            VLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1621 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1647


>gi|209862983 MAP-kinase activating death domain-containing protein
            isoform e [Homo sapiens]
          Length = 1608

 Score = 3171 bits (8221), Expect = 0.0
 Identities = 1601/1647 (97%), Positives = 1606/1647 (97%), Gaps = 39/1647 (2%)

Query: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
            MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60

Query: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
            CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120

Query: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
            GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180

Query: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
            SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240

Query: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
            LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300

Query: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
            LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360

Query: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
            ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420

Query: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
            SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480

Query: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
            DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540

Query: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
            KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600

Query: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
            LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660

Query: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
            THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720

Query: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
            PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP
Sbjct: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780

Query: 781  PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
            PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 781  PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840

Query: 841  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900
            EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP
Sbjct: 841  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900

Query: 901  GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960
            GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW
Sbjct: 901  GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960

Query: 961  LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020
            LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL
Sbjct: 961  LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020

Query: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080
            SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP
Sbjct: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080

Query: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP 1140
            KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI                   P
Sbjct: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI------------------GP 1122

Query: 1141 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1200
            EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV
Sbjct: 1123 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1182

Query: 1201 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1260
            VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK
Sbjct: 1183 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1242

Query: 1261 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ 1320
            PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG+++ ++W                     DQ
Sbjct: 1243 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLW---------------------DQ 1281

Query: 1321 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1380
            MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS
Sbjct: 1282 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1341

Query: 1381 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1440
            YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK
Sbjct: 1342 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1401

Query: 1441 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1500
            QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR
Sbjct: 1402 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1461

Query: 1501 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1560
            NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ
Sbjct: 1462 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1521

Query: 1561 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1620
            VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS
Sbjct: 1522 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1581

Query: 1621 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1647
            VLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1582 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1608


>gi|18860873 MAP-kinase activating death domain-containing protein
            isoform g [Homo sapiens]
          Length = 1581

 Score = 3136 bits (8131), Expect = 0.0
 Identities = 1576/1579 (99%), Positives = 1578/1579 (99%), Gaps = 1/1579 (0%)

Query: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
            MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60

Query: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
            CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120

Query: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
            GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180

Query: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
            SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240

Query: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
            LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300

Query: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
            LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360

Query: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
            ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420

Query: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
            SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480

Query: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
            DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540

Query: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
            KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600

Query: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
            LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660

Query: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
            THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720

Query: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
            PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP
Sbjct: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780

Query: 781  PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
            PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 781  PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840

Query: 841  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900
            EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP
Sbjct: 841  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900

Query: 901  GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960
            GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW
Sbjct: 901  GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960

Query: 961  LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020
            LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL
Sbjct: 961  LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020

Query: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080
            SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP
Sbjct: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080

Query: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP 1140
            KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP
Sbjct: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP 1140

Query: 1141 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1200
            EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV
Sbjct: 1141 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1200

Query: 1201 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1260
            VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK
Sbjct: 1201 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1260

Query: 1261 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ 1320
            PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ
Sbjct: 1261 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ 1320

Query: 1321 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1380
            MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS
Sbjct: 1321 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1380

Query: 1381 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1440
            YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK
Sbjct: 1381 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1440

Query: 1441 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1500
            QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR
Sbjct: 1441 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1500

Query: 1501 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1560
            NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ
Sbjct: 1501 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1560

Query: 1561 VTLEGINLKFMHNQVFIEL 1579
            VTLEGINLKFMHNQ F++L
Sbjct: 1561 VTLEGINLKFMHNQ-FLKL 1578


>gi|209862971 MAP-kinase activating death domain-containing protein
            isoform a [Homo sapiens]
          Length = 1588

 Score = 3120 bits (8089), Expect = 0.0
 Identities = 1581/1647 (95%), Positives = 1586/1647 (96%), Gaps = 59/1647 (3%)

Query: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
            MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60

Query: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
            CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120

Query: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
            GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180

Query: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
            SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240

Query: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
            LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300

Query: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
            LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360

Query: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
            ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420

Query: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
            SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480

Query: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
            DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540

Query: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
            KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600

Query: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
            LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660

Query: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
            THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720

Query: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
            PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP
Sbjct: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780

Query: 781  PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
            PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 781  PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840

Query: 841  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900
            EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK                
Sbjct: 841  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK---------------- 884

Query: 901  GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960
                GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW
Sbjct: 885  ----GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 940

Query: 961  LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020
            LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL
Sbjct: 941  LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1000

Query: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080
            SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP
Sbjct: 1001 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1060

Query: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP 1140
            KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI                   P
Sbjct: 1061 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI------------------GP 1102

Query: 1141 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1200
            EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV
Sbjct: 1103 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1162

Query: 1201 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1260
            VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK
Sbjct: 1163 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1222

Query: 1261 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ 1320
            PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG+++ ++W                     DQ
Sbjct: 1223 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLW---------------------DQ 1261

Query: 1321 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1380
            MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS
Sbjct: 1262 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1321

Query: 1381 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1440
            YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK
Sbjct: 1322 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1381

Query: 1441 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1500
            QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR
Sbjct: 1382 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1441

Query: 1501 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1560
            NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ
Sbjct: 1442 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1501

Query: 1561 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1620
            VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS
Sbjct: 1502 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1561

Query: 1621 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1647
            VLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1562 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1588


>gi|209571517 MAP-kinase activating death domain-containing protein
            isoform h [Homo sapiens]
          Length = 1587

 Score = 3114 bits (8073), Expect = 0.0
 Identities = 1580/1647 (95%), Positives = 1585/1647 (96%), Gaps = 60/1647 (3%)

Query: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
            MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60

Query: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
            CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120

Query: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
            GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180

Query: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
            SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240

Query: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
            LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300

Query: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
            LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360

Query: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
            ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420

Query: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
            SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480

Query: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
            DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540

Query: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
            KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600

Query: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
            LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660

Query: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
            THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720

Query: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
            PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP
Sbjct: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780

Query: 781  PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
            PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 781  PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840

Query: 841  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900
            EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK                
Sbjct: 841  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK---------------- 884

Query: 901  GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960
                GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW
Sbjct: 885  ----GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 940

Query: 961  LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020
            LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL
Sbjct: 941  LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1000

Query: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080
            SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP
Sbjct: 1001 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1060

Query: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP 1140
            KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI                   P
Sbjct: 1061 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI------------------GP 1102

Query: 1141 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1200
            EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVST 
Sbjct: 1103 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVST- 1161

Query: 1201 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1260
            VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK
Sbjct: 1162 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1221

Query: 1261 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ 1320
            PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG+++ ++W                     DQ
Sbjct: 1222 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLW---------------------DQ 1260

Query: 1321 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1380
            MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS
Sbjct: 1261 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1320

Query: 1381 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1440
            YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK
Sbjct: 1321 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1380

Query: 1441 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1500
            QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR
Sbjct: 1381 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1440

Query: 1501 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1560
            NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ
Sbjct: 1441 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1500

Query: 1561 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1620
            VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS
Sbjct: 1501 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1560

Query: 1621 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1647
            VLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1561 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1587


>gi|209862975 MAP-kinase activating death domain-containing protein
            isoform b [Homo sapiens]
          Length = 1565

 Score = 3065 bits (7946), Expect = 0.0
 Identities = 1564/1647 (94%), Positives = 1564/1647 (94%), Gaps = 82/1647 (4%)

Query: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
            MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60

Query: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
            CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120

Query: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
            GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180

Query: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
            SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240

Query: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
            LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300

Query: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
            LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360

Query: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
            ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420

Query: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
            SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480

Query: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
            DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540

Query: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
            KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600

Query: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
            LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660

Query: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
            THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720

Query: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
            PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG                   
Sbjct: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761

Query: 781  PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
                                    AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 762  ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797

Query: 841  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900
            EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP
Sbjct: 798  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 857

Query: 901  GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960
            GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW
Sbjct: 858  GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 917

Query: 961  LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020
            LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL
Sbjct: 918  LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 977

Query: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080
            SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP
Sbjct: 978  SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1037

Query: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP 1140
            KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI                   P
Sbjct: 1038 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIG------------------P 1079

Query: 1141 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1200
            EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV
Sbjct: 1080 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1139

Query: 1201 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1260
            VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK
Sbjct: 1140 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1199

Query: 1261 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ 1320
            PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG                     KERSTLWDQ
Sbjct: 1200 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG---------------------KERSTLWDQ 1238

Query: 1321 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1380
            MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS
Sbjct: 1239 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1298

Query: 1381 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1440
            YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK
Sbjct: 1299 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1358

Query: 1441 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1500
            QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR
Sbjct: 1359 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1418

Query: 1501 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1560
            NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ
Sbjct: 1419 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1478

Query: 1561 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1620
            VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS
Sbjct: 1479 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1538

Query: 1621 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1647
            VLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1539 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1565


>gi|209862979 MAP-kinase activating death domain-containing protein
            isoform c [Homo sapiens]
          Length = 1545

 Score = 3007 bits (7795), Expect = 0.0
 Identities = 1538/1647 (93%), Positives = 1543/1647 (93%), Gaps = 102/1647 (6%)

Query: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
            MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60

Query: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
            CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120

Query: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
            GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180

Query: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
            SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240

Query: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
            LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300

Query: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
            LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360

Query: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
            ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420

Query: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
            SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480

Query: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
            DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540

Query: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
            KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600

Query: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
            LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660

Query: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
            THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720

Query: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
            PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG                   
Sbjct: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761

Query: 781  PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
                                    AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 762  ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797

Query: 841  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900
            EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK                
Sbjct: 798  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK---------------- 841

Query: 901  GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960
                GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW
Sbjct: 842  ----GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 897

Query: 961  LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020
            LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL
Sbjct: 898  LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 957

Query: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080
            SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP
Sbjct: 958  SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1017

Query: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP 1140
            KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI                   P
Sbjct: 1018 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI------------------GP 1059

Query: 1141 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1200
            EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV
Sbjct: 1060 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1119

Query: 1201 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1260
            VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK
Sbjct: 1120 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1179

Query: 1261 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ 1320
            PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG+++ ++W                     DQ
Sbjct: 1180 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLW---------------------DQ 1218

Query: 1321 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1380
            MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS
Sbjct: 1219 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1278

Query: 1381 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1440
            YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK
Sbjct: 1279 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1338

Query: 1441 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1500
            QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR
Sbjct: 1339 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1398

Query: 1501 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1560
            NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ
Sbjct: 1399 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1458

Query: 1561 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1620
            VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS
Sbjct: 1459 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1518

Query: 1621 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1647
            VLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1519 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1545


>gi|209862998 MAP-kinase activating death domain-containing protein
            isoform i [Homo sapiens]
          Length = 1544

 Score = 3001 bits (7779), Expect = 0.0
 Identities = 1537/1647 (93%), Positives = 1542/1647 (93%), Gaps = 103/1647 (6%)

Query: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
            MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60

Query: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
            CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120

Query: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
            GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180

Query: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
            SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240

Query: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
            LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300

Query: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
            LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360

Query: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
            ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420

Query: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
            SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480

Query: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
            DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540

Query: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
            KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600

Query: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
            LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660

Query: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
            THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720

Query: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
            PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG                   
Sbjct: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761

Query: 781  PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
                                    AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 762  ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797

Query: 841  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900
            EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK                
Sbjct: 798  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK---------------- 841

Query: 901  GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960
                GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW
Sbjct: 842  ----GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 897

Query: 961  LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020
            LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL
Sbjct: 898  LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 957

Query: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080
            SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP
Sbjct: 958  SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1017

Query: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP 1140
            KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI                   P
Sbjct: 1018 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI------------------GP 1059

Query: 1141 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1200
            EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVST 
Sbjct: 1060 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVST- 1118

Query: 1201 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1260
            VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK
Sbjct: 1119 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1178

Query: 1261 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ 1320
            PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG+++ ++W                     DQ
Sbjct: 1179 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLW---------------------DQ 1217

Query: 1321 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1380
            MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS
Sbjct: 1218 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1277

Query: 1381 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1440
            YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK
Sbjct: 1278 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1337

Query: 1441 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1500
            QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR
Sbjct: 1338 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1397

Query: 1501 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1560
            NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ
Sbjct: 1398 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1457

Query: 1561 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1620
            VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS
Sbjct: 1458 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1517

Query: 1621 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1647
            VLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1518 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1544


>gi|209863002 MAP-kinase activating death domain-containing protein
            isoform j [Homo sapiens]
          Length = 1541

 Score = 2994 bits (7763), Expect = 0.0
 Identities = 1534/1647 (93%), Positives = 1539/1647 (93%), Gaps = 106/1647 (6%)

Query: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
            MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60

Query: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
            CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120

Query: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
            GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180

Query: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
            SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240

Query: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
            LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300

Query: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
            LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360

Query: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
            ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420

Query: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
            SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480

Query: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
            DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540

Query: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
            KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600

Query: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
            LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660

Query: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
            THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720

Query: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
            PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG                   
Sbjct: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761

Query: 781  PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
                                    AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 762  ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797

Query: 841  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900
            EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK                
Sbjct: 798  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK---------------- 841

Query: 901  GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960
                GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW
Sbjct: 842  ----GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 897

Query: 961  LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020
            LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL
Sbjct: 898  LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 957

Query: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080
            SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP
Sbjct: 958  SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1017

Query: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP 1140
            KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI                   P
Sbjct: 1018 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI------------------GP 1059

Query: 1141 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1200
            EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSE    
Sbjct: 1060 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSE---- 1115

Query: 1201 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1260
            VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK
Sbjct: 1116 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1175

Query: 1261 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ 1320
            PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG+++ ++W                     DQ
Sbjct: 1176 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLW---------------------DQ 1214

Query: 1321 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1380
            MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS
Sbjct: 1215 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1274

Query: 1381 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1440
            YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK
Sbjct: 1275 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1334

Query: 1441 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1500
            QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR
Sbjct: 1335 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1394

Query: 1501 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1560
            NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ
Sbjct: 1395 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1454

Query: 1561 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1620
            VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS
Sbjct: 1455 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1514

Query: 1621 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1647
            VLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1515 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1541


>gi|209862987 MAP-kinase activating death domain-containing protein
            isoform f [Homo sapiens]
          Length = 1479

 Score = 2860 bits (7413), Expect = 0.0
 Identities = 1467/1579 (92%), Positives = 1474/1579 (93%), Gaps = 103/1579 (6%)

Query: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
            MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60

Query: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
            CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120

Query: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
            GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180

Query: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
            SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240

Query: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
            LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300

Query: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
            LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360

Query: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
            ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420

Query: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
            SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480

Query: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
            DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540

Query: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
            KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600

Query: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
            LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660

Query: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
            THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720

Query: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
            PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG                   
Sbjct: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761

Query: 781  PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
                                    AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 762  ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797

Query: 841  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900
            EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK                
Sbjct: 798  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK---------------- 841

Query: 901  GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960
                GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW
Sbjct: 842  ----GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 897

Query: 961  LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020
            LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL
Sbjct: 898  LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 957

Query: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080
            SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP
Sbjct: 958  SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1017

Query: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP 1140
            KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI                   P
Sbjct: 1018 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI------------------GP 1059

Query: 1141 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1200
            EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV
Sbjct: 1060 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1119

Query: 1201 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1260
            VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK
Sbjct: 1120 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1179

Query: 1261 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ 1320
            PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG+++ ++W                     DQ
Sbjct: 1180 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLW---------------------DQ 1218

Query: 1321 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1380
            MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS
Sbjct: 1219 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1278

Query: 1381 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1440
            YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK
Sbjct: 1279 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1338

Query: 1441 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1500
            QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR
Sbjct: 1339 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1398

Query: 1501 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1560
            NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ
Sbjct: 1399 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1458

Query: 1561 VTLEGINLKFMHNQVFIEL 1579
            VTLEGINLKFMHNQ F++L
Sbjct: 1459 VTLEGINLKFMHNQ-FLKL 1476


>gi|239735519 SET binding factor 1 [Homo sapiens]
          Length = 1893

 Score =  103 bits (257), Expect = 1e-21
 Identities = 133/528 (25%), Positives = 200/528 (37%), Gaps = 127/528 (24%)

Query: 10  RLLDYLVIVG-ARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRR 68
           RL DY V+V    HP      Q  ++L+R+P +D  + P P  +  FCQP G     +R 
Sbjct: 3   RLADYFVLVAFGPHPRGSGEGQG-QILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPER- 60

Query: 69  MSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCAS 128
                 T FV  LTD ++    Y  C+ F+   +                +E T      
Sbjct: 61  ---NPPTFFVAVLTDINS-ERHYCACLTFWEPAEP--------------SQETTRV---- 98

Query: 129 EEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFST 188
            E  TE  E G        D     + SP     A +       TL  +  L H   F  
Sbjct: 99  -EDATEREEEG--------DEGGQTHLSPTAP--APSAQLFAPKTLVLVSRLDHTEVFRN 147

Query: 189 FRECLYTLK-RLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREI 247
               +Y +    ++ C E ++G                                      
Sbjct: 148 SLGLIYAIHVEGLNVCLENVIG-------------------------------------- 169

Query: 248 EAWIYRLLRSPVPVSGQKRVDIEVLP---QELQPALTFALPDPSRFTLVDFPLHLPLELL 304
                 LL   VP++G  +  I +     Q +Q  L  +LP  SR ++      L    L
Sbjct: 170 -----NLLTCTVPLAGGSQRTISLGAGDRQVIQTPLADSLP-VSRCSVA-----LLFRQL 218

Query: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364
           G+   L +    L EHKV+  SR Y  L+ +    +A+++PL Y F  +P+LP   A   
Sbjct: 219 GITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILP---AQLL 275

Query: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLEL 424
           ++L  PTP+IIGV A+F   + + +   DV + DLD   V  P   E + I P PE L+ 
Sbjct: 276 EVLSTPTPFIIGVNAAF---QAETQELLDVIVADLDGGTVTIP---ECVHIPPLPEPLQS 329

Query: 425 KKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDS 484
           + H     + +S+   P L L                  DL   P     P    + +  
Sbjct: 330 QTH-----SVLSMVLDPELELA-----------------DLAFPP-----PTTSTSSLKM 362

Query: 485 VDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASR 532
            D   R   +R F  A +LQG++     +R+ P PV+ F   +FL  R
Sbjct: 363 QDKELRAVFLRLF--AQLLQGYRWCLHVVRIHPEPVIRFHKAAFLGQR 408


>gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo
           sapiens]
          Length = 1906

 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)

Query: 25  SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
           +++V+    L+ RYP ED+  F LP  V  FC P G          +  L   ++FV T 
Sbjct: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262

Query: 82  TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
              +     YG  + FY  +                          SEE  TE       
Sbjct: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293

Query: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
           L   SAD               K+ S     T   +C+LSH+PFF  FR+ L  L R   
Sbjct: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335

Query: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
                + G  +                  L +E+  S  +H +             P P 
Sbjct: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360

Query: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
             + R+ +++ P +    L  + P  S   L        L+ LG +  + +L   + EHK
Sbjct: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417

Query: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
           +++ S   + L+    A V+MI+P  +  P +PL P  +A    +L AP P+I+G+ + +
Sbjct: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474

Query: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439
           F     +  P DV  VD+D+N +  I         ILP       KK  K  + +++   
Sbjct: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521

Query: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499
               NL      Q++  L  RP +D     +        G  +  +D+  + A + F   
Sbjct: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570

Query: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546
           A++L+G++ + R +   P          F   +FL SR R    F   + +TQ
Sbjct: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623


>gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo
           sapiens]
          Length = 1863

 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)

Query: 25  SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
           +++V+    L+ RYP ED+  F LP  V  FC P G          +  L   ++FV T 
Sbjct: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262

Query: 82  TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
              +     YG  + FY  +                          SEE  TE       
Sbjct: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293

Query: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
           L   SAD               K+ S     T   +C+LSH+PFF  FR+ L  L R   
Sbjct: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335

Query: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
                + G  +                  L +E+  S  +H +             P P 
Sbjct: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360

Query: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
             + R+ +++ P +    L  + P  S   L        L+ LG +  + +L   + EHK
Sbjct: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417

Query: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
           +++ S   + L+    A V+MI+P  +  P +PL P  +A    +L AP P+I+G+ + +
Sbjct: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474

Query: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439
           F     +  P DV  VD+D+N +  I         ILP       KK  K  + +++   
Sbjct: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521

Query: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499
               NL      Q++  L  RP +D     +        G  +  +D+  + A + F   
Sbjct: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570

Query: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546
           A++L+G++ + R +   P          F   +FL SR R    F   + +TQ
Sbjct: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623


>gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]
          Length = 1496

 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 99/392 (25%), Positives = 151/392 (38%), Gaps = 92/392 (23%)

Query: 25  SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
           ++++    ELL RYP ED+  FPLP  V  FC P G        Q +  +   ++FV T 
Sbjct: 206 ANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTG 265

Query: 82  TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
                G   YG  + FY +F +    E+                               +
Sbjct: 266 A---AGDKVYGAALQFYEAFPRARLSER----------------------------QARA 294

Query: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
           L  LSA          RG+       RSR +    + VLS +P F  FR  L  L R   
Sbjct: 295 LGLLSAVE--------RGRALGGRAVRSRRA----IAVLSRWPAFPAFRAFLTFLYRYSV 342

Query: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
               RL                         +E   S  +H++             P P 
Sbjct: 343 SGPHRLP------------------------LEAHISHFIHNV-------------PFPS 365

Query: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
             + R+ +++ P +    L    P  S   L        L+ LG +  + +L  +L EHK
Sbjct: 366 PQRPRILVQMSPYD---NLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHK 422

Query: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
           +++ S   + L+    A V+MI+PL +  P IPL P  +A    +L AP P+I+G+ +S+
Sbjct: 423 LLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLA---DVLSAPVPFIVGIHSSY 479

Query: 382 FLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVL 413
           F        P DV  VDLD+N +      ++L
Sbjct: 480 FDL---HDPPADVICVDLDTNTLFQTEEKKLL 508


>gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]
          Length = 1673

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 101/395 (25%), Positives = 163/395 (41%), Gaps = 84/395 (21%)

Query: 164 KAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTM 223
           K  S+S N T   +C+LSH+PFF  FR+ L  + +L            +  P        
Sbjct: 65  KMVSKSIN-TNKCICLLSHWPFFEAFRKFLMFIYKL-----------SVSGPH------- 105

Query: 224 WRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFA 283
                  L +E+  S  + ++             P P   + R+ +++    +  AL  +
Sbjct: 106 ------PLPIEKHISHFMQNI-------------PFPSPQRPRILVQL---SVHDALILS 143

Query: 284 LPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343
            P  +   L        L  LG + C  +L  +LLE K++L S     L+    A VAMI
Sbjct: 144 QPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMI 203

Query: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403
           +P ++  P IPL P  +A+   +L AP P+I+GV + +F        P DV  +DLD+N 
Sbjct: 204 FPFQWQCPYIPLCPLSLAA---VLSAPLPFIVGVDSRYFDL---HDPPQDVVCIDLDTNM 257

Query: 404 VIAP-----TNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLL 458
           +         N + LP  P    L   K L   L+S+   TQ         EG  I +  
Sbjct: 258 LYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQ---------EGSAIDM-- 306

Query: 459 GRPSNDLQSTP-STEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFP 517
                    TP   +F+   +   +  +++  + A +RF   A++L+G++ + R +   P
Sbjct: 307 ---------TPIEADFS---WQKKMTQLEMEIQEAFLRFM--ASILKGYRTYLRPITEAP 352

Query: 518 RPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546
                     F    FL SR R    F   L++TQ
Sbjct: 353 SNKATAADSLFDRQGFLKSRDRAYAKFYTLLSKTQ 387


>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
          Length = 1274

 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 42/132 (31%), Positives = 70/132 (53%), Gaps = 5/132 (3%)

Query: 285 PDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIY 344
           P PS   L D+PL    ELLG++  +QV TC+LLE +++L S+DY  L         +++
Sbjct: 259 PGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLF 318

Query: 345 PLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSN 402
           P ++    +P+LP   AS    L AP PY++G+ +     +   ++P +  L  VD+D++
Sbjct: 319 PFQWQHVYVPILP---ASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNH 375

Query: 403 RVIAPTNAEVLP 414
            +  P      P
Sbjct: 376 FIELPEEFPQFP 387


>gi|29788755 SET binding factor 2 [Homo sapiens]
          Length = 1849

 Score = 76.6 bits (187), Expect = 2e-13
 Identities = 70/252 (27%), Positives = 109/252 (43%), Gaps = 49/252 (19%)

Query: 292 LVDFPLH--LPL---------ELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFV 340
           L+  PLH  LP+         + LG+   L +   +L E+KV+  S  +  LS +  A  
Sbjct: 183 LIQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALE 242

Query: 341 AMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLD 400
           ++++PL+Y +P IP+LP   A   ++L +PTP+IIGV + F   K D     DV + DLD
Sbjct: 243 SLMFPLKYSYPYIPILP---AQLLEVLSSPTPFIIGVHSVF---KTDVHELLDVIIADLD 296

Query: 401 SNRVIAPTNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGR 460
              +  P     L  LPEP        L Q  +++SL   P                   
Sbjct: 297 GGTIKIPECIH-LSSLPEPL-------LHQTQSALSLILHP------------------- 329

Query: 461 PSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPV 520
              DL+        P    +    +D   R   +R F  A + QG++   + +R+   PV
Sbjct: 330 ---DLEVADHAFPPPRTALSHSKMLDKEVRAVFLRLF--AQLFQGYRSCLQLIRIHAEPV 384

Query: 521 VAFQAGSFLASR 532
           + F   +FL  R
Sbjct: 385 IHFHKTAFLGQR 396



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 37/111 (33%), Positives = 54/111 (48%), Gaps = 7/111 (6%)

Query: 10  RLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRRM 69
           RL DY ++VG  H    S     ++++R+P +D  + P P  +  FCQP G    R+R  
Sbjct: 3   RLADYFIVVGYDHEKPGSGEGLGKIIQRFPQKDWDDTPFPQGIELFCQPGGWQLSRER-- 60

Query: 70  SLRDDTSFVFTLTDKDTGVTRYGICVNFYRS--FQKRISKEKGEGGAGSRG 118
             +  T FV  LTD D+    Y  C+ FY +    +   KE+ EG A   G
Sbjct: 61  --KQPTFFVVVLTDIDSD-RHYCSCLTFYEAEINLQGTKKEEIEGEAKVSG 108


>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
          Length = 1287

 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 52/195 (26%), Positives = 96/195 (49%), Gaps = 18/195 (9%)

Query: 247 IEAWIYRLLRS-PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLG 305
           +E++IY +L   P+P  G+      +    +   +    P  +   L DFP+    ELLG
Sbjct: 240 LESYIYNVLYEVPLPPPGRS-----LKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLG 294

Query: 306 VDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQ 365
           V+   Q+ TC LLE +++L S+ Y  L        A+++P ++    +P+LP   AS   
Sbjct: 295 VENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILP---ASLLH 351

Query: 366 LLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSNRVIAPTNAEVLPILPE-PESL 422
            L AP PY++G+ ++    +   ++P +  L  VD+D++ +  P +      LP+ P  L
Sbjct: 352 FLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPED------LPQFPNKL 405

Query: 423 ELKKHLKQALASMSL 437
           E  + + + L +  +
Sbjct: 406 EFVQEVSEILMAFGI 420


>gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]
          Length = 1198

 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 59/234 (25%), Positives = 102/234 (43%), Gaps = 54/234 (23%)

Query: 176 SLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEE 235
           ++CV+S +P++++ ++CL  L  L+  C +             + D+  + F   L    
Sbjct: 109 AVCVVSRFPYYNSLKDCLSCLLALLKPCKD------------FEVDSHIKDFAAKL---- 152

Query: 236 KSSALLHDLREIEAWIYRLLRSPVP-----VSGQKRVDIEVLPQELQPALTFALPDPSRF 290
                             L+ SP P     V   K + I VLP    P            
Sbjct: 153 -----------------SLIPSPPPGPLHLVFNMKSLQI-VLPARADP----------ES 184

Query: 291 TLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMF 350
            ++D  LHLPL     +  LQ+LTCIL E ++V  S D+  L++    F+A +YPL++  
Sbjct: 185 PILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQH 244

Query: 351 PVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRV 404
           P +P+L   M      ++APT +++G     F  +   K  D + L+++D   +
Sbjct: 245 PFVPILSDQML---DFVMAPTSFLMGCHLDHF--EEVSKEADGLVLINIDHGSI 293


>gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
          Length = 1137

 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)

Query: 254  LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
            L+ SP P  G+       LP      L    P  SR   VDF        L V   +++ 
Sbjct: 833  LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 890

Query: 314  TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
              +LLE +V+  +   + LS    A VA++YP  +    IP+LP   AS   ++  PTP+
Sbjct: 891  ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 947

Query: 374  IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432
            ++G+ +S  L KL     ++  +V+L S+R I   + E   +LP     +L+  L+QAL
Sbjct: 948  LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 1000


>gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
          Length = 1137

 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)

Query: 254  LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
            L+ SP P  G+       LP      L    P  SR   VDF        L V   +++ 
Sbjct: 833  LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 890

Query: 314  TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
              +LLE +V+  +   + LS    A VA++YP  +    IP+LP   AS   ++  PTP+
Sbjct: 891  ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 947

Query: 374  IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432
            ++G+ +S  L KL     ++  +V+L S+R I   + E   +LP     +L+  L+QAL
Sbjct: 948  LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 1000


>gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo
           sapiens]
          Length = 717

 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)

Query: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
           L+ SP P  G+       LP      L    P  SR   VDF        L V   +++ 
Sbjct: 413 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 470

Query: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
             +LLE +V+  +   + LS    A VA++YP  +    IP+LP   AS   ++  PTP+
Sbjct: 471 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 527

Query: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432
           ++G+ +S  L KL     ++  +V+L S+R I   + E   +LP     +L+  L+QAL
Sbjct: 528 LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 580


>gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]
          Length = 871

 Score = 58.5 bits (140), Expect = 5e-08
 Identities = 50/172 (29%), Positives = 82/172 (47%), Gaps = 12/172 (6%)

Query: 249 AWIYRLLRS----PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELL 304
           A +Y  +RS    P P  G+       LP     ++    P  SR   VDF      + L
Sbjct: 562 ALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLF--KCL 619

Query: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364
            V   ++V   +LLE +V+  +   + LS    A VA +YP  +    IP+LP   AS  
Sbjct: 620 SVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLP---ASMI 676

Query: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTN--AEVLP 414
            ++ +PTP++IG+  S  L +L     ++V +VDL +++ +   +   E+LP
Sbjct: 677 DIVCSPTPFLIGI-LSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILP 727


>gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]
          Length = 1009

 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 49/177 (27%), Positives = 83/177 (46%), Gaps = 7/177 (3%)

Query: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
           ++ +P P  G+  +    LP      +    P  SR   VDF        L V   + V 
Sbjct: 702 VMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDF--ESLFSSLSVRHLVCVF 759

Query: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
             +LLE +V+  +   + LS    A VA+IYP  +    IP+LP  M     ++ +PTP+
Sbjct: 760 ASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMV---DIVCSPTPF 816

Query: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQ 430
           +IG+ +S      +  + ++V +VDL ++R +   + E   ILP    + L+  L+Q
Sbjct: 817 LIGLLSSSLPLLRELPL-EEVLVVDLVNSRFLRQMDDED-SILPRKLQVALEHILEQ 871



 Score = 31.2 bits (69), Expect = 8.7
 Identities = 26/89 (29%), Positives = 41/89 (46%), Gaps = 6/89 (6%)

Query: 10  RLLDYLVIVGARHPSSDSVAQTPELLRRYP--LEDHTEFPLPPDVVFFCQPEGCLSVRQR 67
           +L +Y V+V   H      A  PEL +++P  LE   +F    +      P+ C    + 
Sbjct: 563 QLFEYFVVVSL-HKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKD 621

Query: 68  RMSLRDDTS--FVFTLTDKDTGVTRYGIC 94
            + ++  TS  F F LT +D G  R+G C
Sbjct: 622 WVPVQQFTSETFSFVLTGED-GSRRFGYC 649


>gi|113205087 DENN/MADD domain containing 1C [Homo sapiens]
          Length = 801

 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 70/270 (25%), Positives = 117/270 (43%), Gaps = 36/270 (13%)

Query: 168 RSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLV--DCCSERLLGKKLGIPRGVQRDTMWR 225
           R R  T + LC+LSH P+F  F + L T+  L+  D  +E               + +  
Sbjct: 86  RLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEA-------------EELLQN 132

Query: 226 IFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALP 285
           +F  SL   + S  L              L S V VS  + +         +P   F  P
Sbjct: 133 LFQQSLSGPQASVGLE-------------LGSGVTVSSGQGIPPPTRGNS-KPLSCFVAP 178

Query: 286 DPSRFTLVDFPLHLPLELLGV--DACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343
           D  R   +    +L   ++ V  +  + +   +L E +V+L +   + L+  V A  A++
Sbjct: 179 DSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALL 238

Query: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403
           YP+ +   +IP LP  +        AP PY+IGV AS    ++  K  +DV ++++D+N 
Sbjct: 239 YPMRWEHVLIPTLPPHLL---DYCCAPMPYLIGVHAS-LAERVREKALEDVVVLNVDAN- 293

Query: 404 VIAPTNAEVLPILPEPESLELKKHLKQALA 433
            +  T  +V  + P+  SL   +  K ALA
Sbjct: 294 TLETTFNDVQALPPDVVSLLRLRLRKVALA 323


>gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo
           sapiens]
          Length = 426

 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 62/261 (23%), Positives = 110/261 (42%), Gaps = 45/261 (17%)

Query: 177 LCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEK 236
           LC+LS+ P+F  + + L TL                                   L +E 
Sbjct: 95  LCILSYLPWFEVYYKLLNTL--------------------------------ADYLAKEL 122

Query: 237 SSALLHDLREIEAWIYRLLRSPVPVSGQKRVDI---EVLPQE--LQPALTFALPDPSRFT 291
            + L   LR +         +PV +S  + + I   +VL  +  L P   F  PD +   
Sbjct: 123 ENDLNETLRSLYNHPVPKANTPVNLSVNQEIFIACEQVLKDQPALVPHSYFIAPDVTGLP 182

Query: 292 LVDFPLHLPLELLGVDA--CLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYM 349
            +    +L    + VD    LQ+   +L E ++V+ S   + L+  +    A++YP+ + 
Sbjct: 183 TIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQ 242

Query: 350 FPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTN 409
              IP+LP  +        AP PY+IG+ +S  + ++  K  +DV ++++D+N + +P +
Sbjct: 243 HIYIPVLPPHLL---DYCCAPMPYLIGIHSS-LIERVKNKSLEDVVMLNVDTNTLESPFS 298

Query: 410 AEVLPILPEPESLELKKHLKQ 430
              L  LP      LK  LK+
Sbjct: 299 D--LNNLPSDVVSALKNKLKK 317


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 55.1 bits (131), Expect = 6e-07
 Identities = 58/247 (23%), Positives = 96/247 (38%), Gaps = 13/247 (5%)

Query: 597 SNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPN 656
           SNS  +   S        S+ +D S SDS D  DSS+S SS  D  +     D +  + +
Sbjct: 684 SNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDS 743

Query: 657 VDPLTHAALGDASE----VEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPST 712
            D    +   D+S+        +  +  ++ +    S +S  N    SS S+ +S+S  +
Sbjct: 744 SDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDS 803

Query: 713 VIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPY 772
                +S+ +DS++ D   +   S    S   S    + D   +  G  S      D+  
Sbjct: 804 SNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSS- 862

Query: 773 FEPQYGFPPEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPN 832
                     +  D    S +   S     N +      +    +SDSD+ SDS  SS +
Sbjct: 863 -------NSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDS-SDSSNSSDS 914

Query: 833 STVSNTS 839
           S  SN+S
Sbjct: 915 SDSSNSS 921



 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 58/242 (23%), Positives = 97/242 (40%), Gaps = 42/242 (17%)

Query: 598 NSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNV 657
           +S  +++ S      SDS+ +D   SDS D D S SS SS     S+      + D+ + 
Sbjct: 563 SSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSD- 621

Query: 658 DPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGA 717
                 +  D+S+ E D   +  +++    +S +S +N    S SS +++SS S      
Sbjct: 622 ------SKSDSSKSESDSSDSDSKSDSSDSNSSDSSDN----SDSSDSSNSSNS------ 665

Query: 718 NSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQY 777
            S+ +DS++  D ++   S        S   SN     ++  + S               
Sbjct: 666 -SDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSN-SSESSDSSDSS--------------- 708

Query: 778 GFPPEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSN 837
               + D  +  +S     S   S N +      NS    SDS   SDS  SS +S  S+
Sbjct: 709 ----DSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNS----SDSSDSSDSSNSSDSSDSSD 760

Query: 838 TS 839
           +S
Sbjct: 761 SS 762



 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 66/277 (23%), Positives = 102/277 (36%), Gaps = 11/277 (3%)

Query: 596 DSNSQLAEALSVPPERDSDSEPTDDS-----GSDSMDYDDSSSS--YSSLGDFVSEMMKC 648
           DS+S  +   S     DSDS  + DS      SDS D  DSS+S   S   D  +     
Sbjct: 709 DSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSS 768

Query: 649 DINGDTPNVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASS 708
           D +  + + D    +   D+S        +         DS +S ++    SS+S+ +S+
Sbjct: 769 DSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSN 828

Query: 709 SPSTVIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIY 768
           S  +     +S+ +DS++  D +    S    S   S    + D   +     S      
Sbjct: 829 SSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNES 888

Query: 769 DNPYFEPQYGFPPEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRA 828
            N           + D  +   S     S + S +        NS   +SDS   SDS  
Sbjct: 889 SNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNS--NSSDSSNSSDSSD 946

Query: 829 SSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSN 865
           SS +S  S++S        S +S    N S S   SN
Sbjct: 947 SSDSSNSSDSSNSSDSSNSSDSSD--SNSSDSSDSSN 981



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 57/251 (22%), Positives = 89/251 (35%), Gaps = 13/251 (5%)

Query: 596  DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
            DS++    + S      SDS  + DS   S   D S SS SS     S+      + D+ 
Sbjct: 760  DSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSD 819

Query: 656  NVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIH 715
            + +    +   D+S+       +       G DS++S  +    SS S+ +S S ++   
Sbjct: 820  SSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDS 879

Query: 716  GANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEP 775
              +S+  +S+   D +    S    S   S    + D   +   + S      DN     
Sbjct: 880  SDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSD--SSNSSDSSESSNSSDNSNSSD 937

Query: 776  QYGFPPEED-------EDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRA 828
                    D        D    S +   S     N +      NS    SDS   SDS  
Sbjct: 938  SSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNS----SDSSDSSDSSD 993

Query: 829  SSPNSTVSNTS 839
            SS +S  SN+S
Sbjct: 994  SSDSSDSSNSS 1004



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 63/272 (23%), Positives = 105/272 (38%), Gaps = 7/272 (2%)

Query: 596  DSNSQLAEALSVPPERDSDSEPTDDSG--SDSMDYDDSSSSYSSLGDFVSEMMKCDINGD 653
            DS+     + S      SDS  + DS   SDS D  DSS S  S  D  +     D +  
Sbjct: 1008 DSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDS-SDSSNSSDSSDSSDS 1066

Query: 654  TPNVDPLTHAALGDASEV-EIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPST 712
            + + D    +   D+SE  +  +  N  ++ +    S++S  +    SS S+ +S+S  +
Sbjct: 1067 SDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDS 1126

Query: 713  VIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPY 772
                 +S+ +DS+   D +    S        S   S+     ++  + S      D+  
Sbjct: 1127 SDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSD-SSDSSDSSDSSDSSNSSDSSD 1185

Query: 773  FEPQYGFPPEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPN 832
                       D  +  +S     S   S +        +S   +SDS+  SDS  SS +
Sbjct: 1186 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD--SSDSNESSDSSDSSDS 1243

Query: 833  STVSNTSTEGFGGIMSFASSLYRNHSTSFSLS 864
            S  SN+S        S ++S   + S S S S
Sbjct: 1244 SDSSNSSDSSDSSDSSDSTSDSNDESDSQSKS 1275



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 62/265 (23%), Positives = 101/265 (38%), Gaps = 12/265 (4%)

Query: 596  DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
            DS+     + S      SDS  + DS SDS D  DSS S  S  D  +     D +  + 
Sbjct: 1047 DSSDSSDSSNSSDSSDSSDSSDSSDS-SDSSDSSDSSESSDS-SDSSNSSDSSDSSDSSD 1104

Query: 656  NVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIH 715
            + D    +   D+S+       +         DS NS ++    SS S+ +S S  +   
Sbjct: 1105 SSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSD--SSESSDSSDSSDSSDS 1162

Query: 716  GANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEP 775
              +S+ +DS++  D +    S        S   S+     ++  + S      D+     
Sbjct: 1163 SDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSD-SSDSSDSSDSSDSSDSSDSSDSSD 1221

Query: 776  QYGFPPEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTV 835
                    D +E  +S     S   S N +      +S    SDS+ ESDS++ S N   
Sbjct: 1222 SSDSSDSSDSNESSDSSDSSDSSD-SSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNN 1280

Query: 836  SNTSTEGFGGIMSFASSLYRNHSTS 860
            + + ++      S +     NHSTS
Sbjct: 1281 NGSDSD------SDSEGSDSNHSTS 1299



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 55/260 (21%), Positives = 103/260 (39%), Gaps = 15/260 (5%)

Query: 596 DSNSQLAEALSVPPERDSDSEPTDDS-------GSDSMDYDDSSSSYSSLGDFVSEMMKC 648
           DS+S  + + S     DSDS  + DS        SDS D  DSS S  S     S+    
Sbjct: 568 DSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSS 627

Query: 649 DINGDTPNVDPLTHAALGDASEV----EIDELQNQKEAEEPGPDSENSQENPPLRSSSST 704
               D+ + D  + ++  ++S+     +  +  N   + +    S++S  +    SS+S+
Sbjct: 628 KSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSS 687

Query: 705 TASSSPSTVIHGANSEPADSTEMD--DKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGS 762
            +S S  +     +S+ +DS++ D  D +    S    S   +   S+     ++  + S
Sbjct: 688 DSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSS 747

Query: 763 VRRRIYDNPYFEPQYGFPPEEDEDEQGESYTPRFS--QHVSGNRAQKLLRPNSLRLASDS 820
                 D+             D  +  +S     S   + S N +      NS   ++ S
Sbjct: 748 DSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSS 807

Query: 821 DAESDSRASSPNSTVSNTST 840
           D+   S +S  +S+ S+ S+
Sbjct: 808 DSSDSSDSSDSDSSNSSDSS 827



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 58/261 (22%), Positives = 96/261 (36%), Gaps = 6/261 (2%)

Query: 606 SVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAAL 665
           S     +SDS    ++G+D  D  DS    S   D  S+      + D+ +      +  
Sbjct: 517 STSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSD--SDSSDSSNSSDSSDSSDSDSSDS 574

Query: 666 GDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSEPADST 725
             +S+ +  +  +   ++    DS NS ++     SS ++ SS  S     ++   +DS+
Sbjct: 575 NSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSS 634

Query: 726 EMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFPPEED- 784
           + D K+    S    S   S   S+     +   + S      D+             D 
Sbjct: 635 DSDSKSDSSDSNSSDSSDNS--DSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDS 692

Query: 785 EDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTSTEGFG 844
            D    S +   S     + +      NS    SDS   SDS  SS NS+ S+ S++   
Sbjct: 693 SDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSS-NSSDSSDSSDSSN 751

Query: 845 GIMSFASSLYRNHSTSFSLSN 865
              S  SS   N S S   S+
Sbjct: 752 SSDSSDSSDSSNSSDSSDSSD 772



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 58/279 (20%), Positives = 100/279 (35%), Gaps = 9/279 (3%)

Query: 596  DSNSQLAEALSVPPERDSDSEPTDDS--GSDSMDYDDS--SSSYSSLGDFVSEMMKCDIN 651
            DS++    + S      SDS  + DS   SDS D  DS  SS  S+  D        D +
Sbjct: 736  DSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSS 795

Query: 652  GDTPNVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPS 711
              + + D    +   D+S+    +  N  ++      S++S  +    SS S+  S S S
Sbjct: 796  DSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDS 855

Query: 712  TVIHGA-----NSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRR 766
            +    +     +S+ +DS+   D +    S    +   S   SN     +     S    
Sbjct: 856  SNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSS 915

Query: 767  IYDNPYFEPQYGFPPEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDS 826
               N     +     +        + +       S N +      +S   +  SD+ S  
Sbjct: 916  DSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSD 975

Query: 827  RASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSN 865
             + S NS+ S+ S++      S  SS   + S S   S+
Sbjct: 976  SSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSD 1014



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 55/245 (22%), Positives = 93/245 (37%), Gaps = 24/245 (9%)

Query: 596  DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
            DS+     + S      SDS  + DS SDS D  DSS S S   D  +     D +  + 
Sbjct: 1077 DSSDSSESSDSSDSSNSSDSSDSSDS-SDSSDSSDSSDS-SDSSDSSNSSDSSDSSDSSD 1134

Query: 656  NVDPLTHAALGDASE-VEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVI 714
            + D    +   D+SE  +  +  +  ++ +    S++S  +    SS S+ +S S  +  
Sbjct: 1135 SSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSD 1194

Query: 715  HGANSEPADSTEMDDKAAVGVSKPLPSVPPS--IGKSNVDRRQAEIGEGSVRRRIYDNPY 772
               +S+ +DS++  D +    S        S     SN     ++  + S      D+  
Sbjct: 1195 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSS- 1253

Query: 773  FEPQYGFPPEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPN 832
                      +  D   +S     SQ  SGN              + SD++SDS  S  N
Sbjct: 1254 -------DSSDSSDSTSDSNDESDSQSKSGNGNN-----------NGSDSDSDSEGSDSN 1295

Query: 833  STVSN 837
             + S+
Sbjct: 1296 HSTSD 1300



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 49/230 (21%), Positives = 91/230 (39%), Gaps = 19/230 (8%)

Query: 610 ERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAALGDAS 669
           E D++S    D+  +S +  D+ +   S G   +E    D   DT N D   +   G+  
Sbjct: 480 ESDNNSSSRGDASYNSDESKDNGNGSDSKG---AEDDDSDSTSDTNNSDSNGNGNNGNDD 536

Query: 670 EVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSEPADSTEMDD 729
             + D  + + ++     DS++S  +    SS S+ + SS S     ++S  +DS++  D
Sbjct: 537 NDKSDSGKGKSDSS----DSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSD 592

Query: 730 KAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFPPEEDEDEQG 789
             +   S    S   S    + D   +   +    +   D+             D D + 
Sbjct: 593 SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDS------------SDSDSKS 640

Query: 790 ESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTS 839
           +S     S     + +      ++   +SDS   SDS +SS +S  S++S
Sbjct: 641 DSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSS 690



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 52/251 (20%), Positives = 94/251 (37%), Gaps = 13/251 (5%)

Query: 596  DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
            DS+     + S      SD+  + DS + S   D S SS SS     S+      + D+ 
Sbjct: 913  DSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSN 972

Query: 656  NVDPLTHAALGDASE-------VEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASS 708
            + D    +   D+S+        +  +  N  ++ +    S++S  +    SS S+ +S 
Sbjct: 973  SSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSD 1032

Query: 709  SPSTVIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIY 768
            S  +     +S+ +DS++  D +    S        S   S+     ++  + S      
Sbjct: 1033 SSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSD----SSDSSDSSESSDSS 1088

Query: 769  DNPYFEPQYGFPPEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRA 828
            D+             D  +  +S     S   S +        +S   +SDS   SDS  
Sbjct: 1089 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS--DSSDSSNSSDSSD 1146

Query: 829  SSPNSTVSNTS 839
            SS +S  S++S
Sbjct: 1147 SSESSDSSDSS 1157



 Score = 39.7 bits (91), Expect = 0.024
 Identities = 54/259 (20%), Positives = 94/259 (36%), Gaps = 18/259 (6%)

Query: 596  DSNSQLAEALSVPPERDSDSEPTD--------------DSGSDSMDYDDSSSSYSSLGDF 641
            DSN     + S      SDS+ +D              DS   S   D+S+SS SS    
Sbjct: 884  DSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSD 943

Query: 642  VSEMMKCDINGDTPN-VDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRS 700
             S+      + D+ N  D    +   D++  +  +  N  ++ +    S++S  +    S
Sbjct: 944  SSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNS 1003

Query: 701  SSSTTASSSPSTVIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGE 760
            S S+ +S S  +     +S  +DS+   D +    S        S   S+     ++  +
Sbjct: 1004 SDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSD-SSNSSDSSD 1062

Query: 761  GSVRRRIYDNPYFEPQYGFPPEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDS 820
             S      D+   +        E  D    S +   S     + +      +    +SDS
Sbjct: 1063 SSDSSDSSDSS--DSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1120

Query: 821  DAESDSRASSPNSTVSNTS 839
               SDS  SS +S  S++S
Sbjct: 1121 SNSSDSSDSSDSSDSSDSS 1139



 Score = 39.3 bits (90), Expect = 0.032
 Identities = 36/108 (33%), Positives = 47/108 (43%), Gaps = 4/108 (3%)

Query: 1148 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRS---SSQDSEVSTVVSNS 1204
            D   +    S  S+DS  S  SS      DS  G       RS   +S DS  S+  SNS
Sbjct: 817  DSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNS 876

Query: 1205 SGETLGADSDLSSNAGDGPGGEGSVHLASS-RGTLSDSEIETNSATST 1251
            S  +  +DS+ SSN+ D      S    SS     SDS   +NS+ S+
Sbjct: 877  SDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSS 924



 Score = 37.4 bits (85), Expect = 0.12
 Identities = 34/105 (32%), Positives = 48/105 (45%), Gaps = 6/105 (5%)

Query: 1152 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1211
            ++   S  S+DS  S  SS      DS    S      S S DS  S+  S+SS  + G+
Sbjct: 792  SDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGS 851

Query: 1212 DSDLS-----SNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1251
            DSD S     SN+ D      S + + S  + SDS   +NS+ S+
Sbjct: 852  DSDSSNRSDSSNSSDSSDSSDSSNSSDSSDS-SDSNESSNSSDSS 895



 Score = 37.0 bits (84), Expect = 0.16
 Identities = 65/331 (19%), Positives = 122/331 (36%), Gaps = 27/331 (8%)

Query: 618 TDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAALGDASEVEIDELQ 677
           ++  G DS D+DD S      GD  +   + + N D  +      ++ GDAS    +   
Sbjct: 445 SNSDGYDSYDFDDKSMQ----GDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKD 500

Query: 678 NQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSEPADSTEMDDKAAVGVSK 737
           N   ++  G + ++S       S+S T  S S        N    +  + +DK+  G  K
Sbjct: 501 NGNGSDSKGAEDDDSD------STSDTNNSDS--------NGNGNNGNDDNDKSDSGKGK 546

Query: 738 PLPSVPPSIGKSN-VDRRQAEIGEGSVRRRIYDNPYFEPQYGFPPEED------EDEQGE 790
              S   S   SN  D   +   + S      D+   +       + D        +  +
Sbjct: 547 SDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSD 606

Query: 791 SYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFA 850
           S     S   S +   K     S   +SDSD++SDS  S+ + +  N+ +       + +
Sbjct: 607 SSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSS 666

Query: 851 SSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGPGSGEGNRRAL 910
            S   + S+  S S+ +  +  + + +    S +    +   +  +++   S   N  + 
Sbjct: 667 DSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSD--SDSSDSSDSSNSNSS 724

Query: 911 VDQKSSVIKHSPTVKREPPSPQGRSSNSSEN 941
               S+    S +      S    SSNSS++
Sbjct: 725 DSDSSNSSDSSDSSNSSDSSDSSDSSNSSDS 755



 Score = 37.0 bits (84), Expect = 0.16
 Identities = 28/99 (28%), Positives = 44/99 (44%)

Query: 1152 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1211
            ++   S  S+DS  S  SS      DS      +    S S DS  S+  S+SS  +  +
Sbjct: 936  SDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSS 995

Query: 1212 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1250
            DS  SSN+ D      S   ++S  + + S+   +S +S
Sbjct: 996  DSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSS 1034



 Score = 36.6 bits (83), Expect = 0.21
 Identities = 32/101 (31%), Positives = 47/101 (46%), Gaps = 4/101 (3%)

Query: 1152 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1211
            ++   S  S+DS  S  SS      DS      +    S+S DS  S   S+SS  +  +
Sbjct: 783  SDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNS---SDSSDSSNSS 839

Query: 1212 DSDLSSNAGDGPGGEGSVHLASSRGT-LSDSEIETNSATST 1251
            DS  SS++ DG   + S    SS  +  SDS   +NS+ S+
Sbjct: 840  DSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSS 880



 Score = 36.6 bits (83), Expect = 0.21
 Identities = 30/95 (31%), Positives = 43/95 (45%), Gaps = 4/95 (4%)

Query: 1157 SQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLS 1216
            S  S+DS  S  SS      +S      +    SS  DS  S+  S+SS  +  +DS  S
Sbjct: 867  SSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSES 926

Query: 1217 SNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1251
            SN+ D      S + + S    SDS   +NS+ S+
Sbjct: 927  SNSSDNSNSSDSSNSSDS----SDSSDSSNSSDSS 957



 Score = 36.6 bits (83), Expect = 0.21
 Identities = 31/95 (32%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 1157 SQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLS 1216
            S  S+DS  S  SS   +   S    S      S S DS  S+  SNSS  +  +DS  S
Sbjct: 956  SSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS 1015

Query: 1217 SNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1251
            SN+ D      S + + S  + SDS   ++S+ S+
Sbjct: 1016 SNSSDSSNSSDSSNSSDSSDS-SDSSDSSDSSDSS 1049



 Score = 36.6 bits (83), Expect = 0.21
 Identities = 34/126 (26%), Positives = 52/126 (41%), Gaps = 11/126 (8%)

Query: 1152 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1211
            ++   S  S+DS  S  SS      DS           S S DS  S+  S+SS     +
Sbjct: 1187 SDSSDSSDSSDSSDSSDSSDSSDSSDS-----------SDSSDSSDSSDSSDSSDSNESS 1235

Query: 1212 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSP 1271
            DS  SS++ D      S   + S  + SDS  E++S + +  G  +        + + S 
Sbjct: 1236 DSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSN 1295

Query: 1272 IRTSED 1277
              TS+D
Sbjct: 1296 HSTSDD 1301



 Score = 36.2 bits (82), Expect = 0.27
 Identities = 34/101 (33%), Positives = 46/101 (45%), Gaps = 5/101 (4%)

Query: 1152 TEEKKSQISADSGVSLTS-SSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLG 1210
            +E   S  S+DS  S +S SS     DS    S      S+S DS  S+  SNSS  +  
Sbjct: 699  SESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDS 758

Query: 1211 ADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1251
            +DS  SS++ D      S    S     SDS   +NS+ S+
Sbjct: 759  SDSSNSSDSSDSSDSSDS----SDSSNSSDSNDSSNSSDSS 795



 Score = 35.8 bits (81), Expect = 0.35
 Identities = 33/132 (25%), Positives = 55/132 (41%), Gaps = 1/132 (0%)

Query: 1148 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1207
            D  +++   S  S+DS  S  SS      DS    S +    S S DS+  +  S+S+  
Sbjct: 589  DSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSS 648

Query: 1208 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKL 1267
                +SD SS++ +      S   + S  + S S+   +S +S     ++S + S     
Sbjct: 649  DSSDNSD-SSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDS 707

Query: 1268 AGSPIRTSEDVS 1279
            + S    S D S
Sbjct: 708  SDSDSSDSSDSS 719



 Score = 35.8 bits (81), Expect = 0.35
 Identities = 30/104 (28%), Positives = 48/104 (46%), Gaps = 1/104 (0%)

Query: 1148 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1207
            D  ++ +  +  S+DS  S +S S  +   S    S      S S DS  S+  S+SS  
Sbjct: 711  DSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDS 770

Query: 1208 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1251
            +  +DS  SSN+ D      S   + S  + SDS   ++S+ S+
Sbjct: 771  SDSSDSSDSSNSSDSNDSSNSSDSSDSSNS-SDSSNSSDSSDSS 813



 Score = 35.4 bits (80), Expect = 0.46
 Identities = 28/104 (26%), Positives = 45/104 (43%)

Query: 1148 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1207
            D  +++   S  S+DS  S  S S  ++  S    S +    SS  DS  S+  S+SS  
Sbjct: 548  DSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDS 607

Query: 1208 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1251
            +  +DS  SS++ D           SS         ++NS+ S+
Sbjct: 608  SDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSS 651



 Score = 35.4 bits (80), Expect = 0.46
 Identities = 31/100 (31%), Positives = 45/100 (45%), Gaps = 1/100 (1%)

Query: 1153 EEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGAD 1212
            E   S  S+DS  S  S S  +   S    S      S S +S  ++  S+SS  +  +D
Sbjct: 887  ESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSD 946

Query: 1213 SDLSSNAGDGPGGEGSVHLA-SSRGTLSDSEIETNSATST 1251
            S  SSN+ D      S + + SS    SDS   +NS+ S+
Sbjct: 947  SSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSS 986



 Score = 35.4 bits (80), Expect = 0.46
 Identities = 30/100 (30%), Positives = 46/100 (46%), Gaps = 13/100 (13%)

Query: 1152 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1211
            ++   S  S+DS  S  SS      DS           S+S DS  S+  SNSS  +  +
Sbjct: 912  SDSSDSSNSSDSSESSNSSDNSNSSDS-----------SNSSDSSDSSDSSNSSDSSNSS 960

Query: 1212 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1251
            DS  SS++ D    + S   +S+    SDS   ++S+ S+
Sbjct: 961  DSSNSSDSSDSNSSDSSD--SSNSSDSSDSSDSSDSSDSS 998



 Score = 35.4 bits (80), Expect = 0.46
 Identities = 32/101 (31%), Positives = 44/101 (43%), Gaps = 6/101 (5%)

Query: 1151 ETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLG 1210
            ++ +  S  S+DS  S  SS      DS    S      S S DS  S+  SNSS  +  
Sbjct: 967  DSSDSNSSDSSDSSNSSDSSDSSDSSDS--SDSSDSSNSSDSSDSSDSSDSSNSSDSSNS 1024

Query: 1211 ADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1251
            +DS  SS++ D      S    S     SDS   +NS+ S+
Sbjct: 1025 SDSSNSSDSSDSSDSSDS----SDSSDSSDSSDSSNSSDSS 1061



 Score = 35.0 bits (79), Expect = 0.60
 Identities = 36/135 (26%), Positives = 55/135 (40%), Gaps = 16/135 (11%)

Query: 1152 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1211
            ++   S  S+DS  S  SS      DS           S+S DS  S+  S+SS  +  +
Sbjct: 735  SDSSNSSDSSDSSDSSNSSDSSDSSDS-----------SNSSDSSDSSDSSDSSDSSNSS 783

Query: 1212 DSDLSSNAGDGPGGEGSVHLASSRGT-----LSDSEIETNSATSTIFGKAHSLKPSIKEK 1266
            DS+ SSN+ D      S   ++S  +      SDS+   +S +S     + S   S    
Sbjct: 784  DSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSD 843

Query: 1267 LAGSPIRTSEDVSQR 1281
             + S   +  D S R
Sbjct: 844  SSDSSDGSDSDSSNR 858



 Score = 34.7 bits (78), Expect = 0.78
 Identities = 32/104 (30%), Positives = 46/104 (44%), Gaps = 3/104 (2%)

Query: 1148 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1207
            D   ++   S  S+DS  S  SS      DS    S      S S DS  S+  SNSS  
Sbjct: 970  DSNSSDSSDSSNSSDSSDSSDSSDSSDSSDS--SNSSDSSDSSDSSDSSNSSDSSNSSDS 1027

Query: 1208 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1251
            +  +DS  SS++ D      S   + S  + SDS   ++S+ S+
Sbjct: 1028 SNSSDSSDSSDSSDSSDSSDSSDSSDSSNS-SDSSDSSDSSDSS 1070



 Score = 34.3 bits (77), Expect = 1.0
 Identities = 29/105 (27%), Positives = 50/105 (47%), Gaps = 4/105 (3%)

Query: 1148 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSS-SQDSEVSTVVSNSSG 1206
            D  +++   S  S+DS  S + SS  +D DS    + +    SS S DS  S+  S+S  
Sbjct: 565  DSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKS 624

Query: 1207 ETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1251
            ++  ++SD S +       + +   +S     SDS   +NS+ S+
Sbjct: 625  DSSKSESDSSDSDSKSDSSDSN---SSDSSDNSDSSDSSNSSNSS 666



 Score = 34.3 bits (77), Expect = 1.0
 Identities = 31/106 (29%), Positives = 45/106 (42%), Gaps = 14/106 (13%)

Query: 1148 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1207
            D  ++    S  ++DS  S  SS+     DS           S S DS  S+  SNSS  
Sbjct: 641  DSSDSNSSDSSDNSDSSDSSNSSNSSDSSDS-----------SDSSDSSSSSDSSNSSDS 689

Query: 1208 TLGADSDLS---SNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1250
            +  +DS  S   S++ D    + S    SS    SDS+   +S +S
Sbjct: 690  SDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSS 735



 Score = 34.3 bits (77), Expect = 1.0
 Identities = 31/104 (29%), Positives = 45/104 (43%), Gaps = 3/104 (2%)

Query: 1148 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1207
            D   ++   +  S+DS  S  SS      DS    S +    S+S DS  S+  SNSS  
Sbjct: 644  DSNSSDSSDNSDSSDSSNSSNSSDSSDSSDS--SDSSSSSDSSNSSDSSDSSDSSNSSES 701

Query: 1208 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1251
            +  +DS   S++ D      S    S     SDS   +NS+ S+
Sbjct: 702  SDSSDSS-DSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSS 744



 Score = 34.3 bits (77), Expect = 1.0
 Identities = 34/106 (32%), Positives = 49/106 (46%), Gaps = 8/106 (7%)

Query: 1152 TEEKKSQISADSGVSLTSS-----SQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSG 1206
            ++   S  S+DS  S  SS     S  +D DS    S +    SS  DS  S+  S+SS 
Sbjct: 681  SDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDS-SDSSNSNSSDSDSSNSSDSSDSSN 739

Query: 1207 ETLGADSDLSSNAGDGPGGEGSVHLASSRGT--LSDSEIETNSATS 1250
             +  +DS  SSN+ D      S + + S  +   SDS   +NS+ S
Sbjct: 740  SSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDS 785



 Score = 33.9 bits (76), Expect = 1.3
 Identities = 32/100 (32%), Positives = 43/100 (43%), Gaps = 5/100 (5%)

Query: 1151 ETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLG 1210
            E++   S   +DS  S +S S      S    S      S S DS  S+  S+SS  +  
Sbjct: 630  ESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDS 689

Query: 1211 ADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1250
            +DS  SSN+      E S    SS    SDS   +NS +S
Sbjct: 690  SDSSDSSNSS-----ESSDSSDSSDSDSSDSSDSSNSNSS 724



 Score = 33.9 bits (76), Expect = 1.3
 Identities = 31/102 (30%), Positives = 45/102 (44%), Gaps = 13/102 (12%)

Query: 1152 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1211
            ++   S  S+DS  S  SS+     DS           S S DS  S+  S+SS  +  +
Sbjct: 1037 SDSSDSSDSSDSSDSSDSSNSSDSSDS-----------SDSSDSSDSSDSSDSSDSSESS 1085

Query: 1212 DSDLSSNAGDGPGGEGSVHLASSRGTL--SDSEIETNSATST 1251
            DS  SSN+ D      S   + S  +   SDS   +NS+ S+
Sbjct: 1086 DSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSS 1127



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 31/108 (28%), Positives = 47/108 (43%), Gaps = 7/108 (6%)

Query: 1148 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1207
            D  ++ +  S  S+DS  S  SS      DS      +     S  DS   +  SNSS  
Sbjct: 811  DSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSS---DGSDSDSSNRSDSSNSSDS 867

Query: 1208 TLGADSDLSSNAGDGPGGEGSVHLA----SSRGTLSDSEIETNSATST 1251
            +  +DS  SS++ D      S + +    SS  + SDS   +NS+ S+
Sbjct: 868  SDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSS 915



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 30/100 (30%), Positives = 46/100 (46%), Gaps = 12/100 (12%)

Query: 1152 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1211
            ++   S  S+DS  S  SS      DS           S+S DS  S+  SNSS  +  +
Sbjct: 989  SDSSDSSDSSDSSNSSDSSDSSDSSDS-----------SNSSDSSNSSDSSNSSDSSDSS 1037

Query: 1212 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1251
            DS  SS++ D      S + + S  + SDS   ++S+ S+
Sbjct: 1038 DSSDSSDSSDSSDSSDSSNSSDSSDS-SDSSDSSDSSDSS 1076



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 31/100 (31%), Positives = 45/100 (45%), Gaps = 3/100 (3%)

Query: 1152 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1211
            ++   S  S+DS  S  SS      DS    S      S S DS  S+  S+SS  +  +
Sbjct: 1088 SDSSNSSDSSDSSDSSDSSDSSDSSDS--SDSSDSSNSSDSSDSSDSSDSSDSSNSSDSS 1145

Query: 1212 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1251
            DS  SS++ D      S   + S  + SDS   +NS+ S+
Sbjct: 1146 DSSESSDSSDSSDSSDSSDSSDSSDS-SDSSDSSNSSDSS 1184



 Score = 33.1 bits (74), Expect = 2.3
 Identities = 27/100 (27%), Positives = 46/100 (46%), Gaps = 1/100 (1%)

Query: 1152 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1211
            ++   S  S+DS  S  S+      DS    + +    S S +S  S+  SNSS  +  +
Sbjct: 868  SDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESS 927

Query: 1212 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1251
            +S  +SN+ D      S   + S  + SDS   ++S+ S+
Sbjct: 928  NSSDNSNSSDSSNSSDSSDSSDSSNS-SDSSNSSDSSNSS 966



 Score = 32.7 bits (73), Expect = 3.0
 Identities = 28/104 (26%), Positives = 48/104 (46%), Gaps = 9/104 (8%)

Query: 1148 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1207
            D G+ +   S   +    + + SS  +D DS           +SS DS+ S   S+ S +
Sbjct: 541  DSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDS--------NSSSDSDSSDSDSSDSSD 592

Query: 1208 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDS-EIETNSATS 1250
            +  +DS  SS++ D      S   + S  + SDS + E++S+ S
Sbjct: 593  SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDS 636



 Score = 32.7 bits (73), Expect = 3.0
 Identities = 28/101 (27%), Positives = 46/101 (45%), Gaps = 1/101 (0%)

Query: 1152 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1211
            ++   S  S +S  S  SS      DS    S      S S +S  S+  SNSS  +  +
Sbjct: 877  SDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSS 936

Query: 1212 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSE-IETNSATST 1251
            DS  SS++ D      S   ++S  + + S+  ++NS+ S+
Sbjct: 937  DSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSS 977



 Score = 32.7 bits (73), Expect = 3.0
 Identities = 26/99 (26%), Positives = 43/99 (43%)

Query: 1152 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1211
            ++   S  S++S  S  SS      DS      +    SS  +S  S+  SNSS  +  +
Sbjct: 930  SDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSS 989

Query: 1212 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1250
            DS  SS++ D      S   + S  + + S+   +S +S
Sbjct: 990  DSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSS 1028



 Score = 32.7 bits (73), Expect = 3.0
 Identities = 30/100 (30%), Positives = 45/100 (45%), Gaps = 12/100 (12%)

Query: 1152 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1211
            ++   S  S+DS  S  SS+     DS           S S DS  S+  S+SS  +  +
Sbjct: 1010 SDSSDSSNSSDSSNSSDSSNSSDSSDS-----------SDSSDSSDSSDSSDSSDSSNSS 1058

Query: 1212 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1251
            DS  SS++ D      S   + S  + SDS   +NS+ S+
Sbjct: 1059 DSSDSSDSSDSSDSSDSSDSSDSSES-SDSSDSSNSSDSS 1097



 Score = 32.7 bits (73), Expect = 3.0
 Identities = 31/100 (31%), Positives = 45/100 (45%), Gaps = 3/100 (3%)

Query: 1152 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1211
            ++   S  S+DS  S  SS      DS    S      S S DS  S+  S+SS  +  +
Sbjct: 1049 SDSSDSSNSSDSSDSSDSSDSSDSSDS--SDSSDSSESSDSSDSSNSSDSSDSSDSSDSS 1106

Query: 1212 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1251
            DS  SS++ D      S   + S  + SDS   +NS+ S+
Sbjct: 1107 DSSDSSDSSDSSDSSNSSDSSDSSDS-SDSSDSSNSSDSS 1145



 Score = 32.7 bits (73), Expect = 3.0
 Identities = 31/100 (31%), Positives = 45/100 (45%), Gaps = 3/100 (3%)

Query: 1152 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1211
            ++   S  S+DS  S  SS      DS    S      S S DS  S+  S+SS  +  +
Sbjct: 1157 SDSSDSSDSSDSSDSSDSSDSSNSSDS--SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1214

Query: 1212 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1251
            DS  SS++ D      S   + S  + SDS   +NS+ S+
Sbjct: 1215 DSSDSSDSSDSSDSSDSNESSDSSDS-SDSSDSSNSSDSS 1253



 Score = 32.3 bits (72), Expect = 3.9
 Identities = 29/103 (28%), Positives = 47/103 (45%), Gaps = 3/103 (2%)

Query: 1152 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSS-SQDSEVSTVVSNSSGETLG 1210
            ++   S  S+DS  S  SS+     DS    + +    SS S DS+ S    +S+  +  
Sbjct: 666  SDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSD 725

Query: 1211 ADSDLSSNAGDGPGGEGSVHLASSRGT--LSDSEIETNSATST 1251
            +DS  SS++ D      S   + S  +   SDS   +NS+ S+
Sbjct: 726  SDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSS 768



 Score = 32.3 bits (72), Expect = 3.9
 Identities = 28/94 (29%), Positives = 40/94 (42%), Gaps = 11/94 (11%)

Query: 1157 SQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLS 1216
            S  S+DS  S  SS      DS           S+S DS  S+  S+SS  +  +DS  S
Sbjct: 1006 SSDSSDSSDSSNSSDSSNSSDS-----------SNSSDSSDSSDSSDSSDSSDSSDSSDS 1054

Query: 1217 SNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1250
            SN+ D      S   + S  +   S+   +S +S
Sbjct: 1055 SNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSS 1088



 Score = 32.3 bits (72), Expect = 3.9
 Identities = 31/100 (31%), Positives = 45/100 (45%), Gaps = 3/100 (3%)

Query: 1152 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1211
            ++   S  S+DS  S  SS      DS    S      S S DS  S+  S+SS  +  +
Sbjct: 1076 SDSSDSSESSDSSDSSNSSDSSDSSDS--SDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1133

Query: 1212 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1251
            DS  SSN+ D      S   + S  + SDS   ++S+ S+
Sbjct: 1134 DSSDSSNSSDSSDSSESSDSSDSSDS-SDSSDSSDSSDSS 1172



 Score = 32.3 bits (72), Expect = 3.9
 Identities = 30/100 (30%), Positives = 44/100 (44%), Gaps = 6/100 (6%)

Query: 1152 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1211
            ++   S  S+DS  S  SS      DS           S S DS  S+  S+SS  +  +
Sbjct: 1118 SDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSES-----SDSSDSSDSSDSSDSSDSSDSS 1172

Query: 1212 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1251
            DS  SSN+ D      S   + S  + SDS   ++S+ S+
Sbjct: 1173 DSSDSSNSSDSSDSSDSSDSSDSSDS-SDSSDSSDSSDSS 1211



 Score = 32.3 bits (72), Expect = 3.9
 Identities = 30/100 (30%), Positives = 44/100 (44%), Gaps = 9/100 (9%)

Query: 1152 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1211
            ++   S  S+DS  S  SS      DS           S S DS  S+  SNSS  +  +
Sbjct: 1136 SDSSNSSDSSDSSESSDSSDSSDSSDSSDS--------SDSSDSSDSSDSSNSSDSSDSS 1187

Query: 1212 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1251
            DS  SS++ D      S   + S  + SDS   ++S+ S+
Sbjct: 1188 DSSDSSDSSDSSDSSDSSDSSDSSDS-SDSSDSSDSSDSS 1226



 Score = 32.0 bits (71), Expect = 5.1
 Identities = 30/100 (30%), Positives = 44/100 (44%), Gaps = 12/100 (12%)

Query: 1152 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1211
            +    S  S+DS  S  SSS     +S           S S DS  S+  S SS  +  +
Sbjct: 660  SNSSNSSDSSDSSDSSDSSSSSDSSNS-----------SDSSDSSDSSNSSESSDSSDSS 708

Query: 1212 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1251
            DSD SS++ D      S   +S+    SDS   ++S+ S+
Sbjct: 709  DSD-SSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSS 747



 Score = 32.0 bits (71), Expect = 5.1
 Identities = 33/107 (30%), Positives = 47/107 (43%), Gaps = 4/107 (3%)

Query: 1148 DLGETEEKKSQISADSGVSLTSS-SQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSG 1206
            D   ++   S  S+DS  S  SS S  +  +S    S      S S DS  S+  SNSS 
Sbjct: 902  DSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSD 961

Query: 1207 ETLGADSDLSSNAGDGPGGEGSVHLASSRGT--LSDSEIETNSATST 1251
             +  +DS   SN+ D      S   + S  +   SDS   +NS+ S+
Sbjct: 962  SSNSSDSS-DSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSS 1007



 Score = 32.0 bits (71), Expect = 5.1
 Identities = 29/95 (30%), Positives = 41/95 (43%), Gaps = 1/95 (1%)

Query: 1157 SQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSS-SQDSEVSTVVSNSSGETLGADSDL 1215
            S  S+DS  S  SS      DS      +    SS S DS  S+  S+SS  +  +DS  
Sbjct: 1060 SSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSD 1119

Query: 1216 SSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1250
            SSN+ D      S   + S  +   S+   +S +S
Sbjct: 1120 SSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSS 1154



 Score = 31.6 bits (70), Expect = 6.6
 Identities = 36/132 (27%), Positives = 54/132 (40%), Gaps = 3/132 (2%)

Query: 1148 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1207
            D   +    S  S+DS  S  SS+     DS    S      S S DS  S+  S+SS  
Sbjct: 852  DSDSSNRSDSSNSSDSSDSSDSSNSSDSSDS--SDSNESSNSSDSSDSSNSSD-SDSSDS 908

Query: 1208 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKL 1267
            +  +DS  SSN+ D      S   ++S  + + S+   +S +S     ++S   S     
Sbjct: 909  SNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDS 968

Query: 1268 AGSPIRTSEDVS 1279
            + S    S D S
Sbjct: 969  SDSNSSDSSDSS 980



 Score = 31.2 bits (69), Expect = 8.7
 Identities = 28/101 (27%), Positives = 42/101 (41%), Gaps = 2/101 (1%)

Query: 1152 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1211
            ++   S   +DS  S  S S  +   S    S      S S DS  S+  S+SS  +  +
Sbjct: 842  SDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSS 901

Query: 1212 DSDLS--SNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1250
            DSD S  SN+ D      S   + S  +  +S    +S +S
Sbjct: 902  DSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSS 942


>gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo
           sapiens]
          Length = 755

 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 59/254 (23%), Positives = 105/254 (41%), Gaps = 51/254 (20%)

Query: 177 LCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEK 236
           LC+LS+ P+F  + + L TL                                   L +E 
Sbjct: 95  LCILSYLPWFEVYYKLLNTL--------------------------------ADYLAKEL 122

Query: 237 SSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFP 296
            + L   LR        L   PVP +    V++ V    + P +T     P    L ++ 
Sbjct: 123 ENDLNETLRS-------LYNHPVPKANTP-VNLSVHSYFIAPDVTGLPTIPESRNLTEY- 173

Query: 297 LHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLL 356
                  + V+  LQ+   +L E ++V+ S   + L+  +    A++YP+ +    IP+L
Sbjct: 174 ----FVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVL 229

Query: 357 PTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPIL 416
           P  +        AP PY+IG+ +S  + ++  K  +DV ++++D+N + +P +   L  L
Sbjct: 230 PPHLL---DYCCAPMPYLIGIHSS-LIERVKNKSLEDVVMLNVDTNTLESPFSD--LNNL 283

Query: 417 PEPESLELKKHLKQ 430
           P      LK  LK+
Sbjct: 284 PSDVVSALKNKLKK 297


>gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]
          Length = 471

 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 37/146 (25%), Positives = 65/146 (44%), Gaps = 6/146 (4%)

Query: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
           L  +  P  G+       +P      ++   P  S    VDF   L    L  +  LQ+ 
Sbjct: 191 LREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLL--HCLSFEQILQIF 248

Query: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
              +LE K++  +   + LS  + A  A++YP  +    IP++P  + +    +  PTP+
Sbjct: 249 ASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLAT---VCCPTPF 305

Query: 374 IIGVPASFFLYKLDFKMPDDVWLVDL 399
           ++GV   F    +D  M ++V LV+L
Sbjct: 306 MVGVQMRFQQEVMDSPM-EEVLLVNL 330


>gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens]
          Length = 559

 Score = 48.9 bits (115), Expect = 4e-05
 Identities = 39/151 (25%), Positives = 69/151 (45%), Gaps = 8/151 (5%)

Query: 282 FALPDPSRFTLVDFPLHLPLELLGVDA--CLQVLTCILLEHKVVLQSRDYNALSMSVMAF 339
           F +PD      +    +L    + VD    L +   +L E ++++     + L+  +   
Sbjct: 155 FTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGS 214

Query: 340 VAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDL 399
            AM+YP+ +    IP+LP  +        AP PY+IG+  S  + K+     DDV ++++
Sbjct: 215 AAMLYPMYWQHVYIPVLPPHLL---DYCCAPMPYLIGIHLS-LMEKVRNMALDDVVILNV 270

Query: 400 DSNRVIAPTNAEVLPILPEPESLELKKHLKQ 430
           D+N +  P   + L  LP      LK  LK+
Sbjct: 271 DTNTLETP--FDDLQSLPNDVISSLKNRLKK 299


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.132    0.382 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 66,263,724
Number of Sequences: 37866
Number of extensions: 3260397
Number of successful extensions: 15388
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 41
Number of HSP's successfully gapped in prelim test: 169
Number of HSP's that attempted gapping in prelim test: 13928
Number of HSP's gapped (non-prelim): 1028
length of query: 1647
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1531
effective length of database: 13,855,062
effective search space: 21212099922
effective search space used: 21212099922
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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