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Search of human proteins with 207029299
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|207029299 NIMA-related kinase 10 isoform 3 [Homo sapiens]
(712 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|207029299 NIMA-related kinase 10 isoform 3 [Homo sapiens] 1411 0.0
gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens] 97 7e-20
gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens] 97 7e-20
gi|4505373 NIMA-related kinase 2 [Homo sapiens] 96 9e-20
gi|19424132 NIMA-related kinase 7 [Homo sapiens] 96 2e-19
gi|163310763 serine/threonine kinase 32A isoform 1 [Homo sapiens] 96 2e-19
gi|41872673 NIMA-related kinase 1 [Homo sapiens] 92 1e-18
gi|8923754 serine/threonine kinase 32B [Homo sapiens] 90 8e-18
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 89 1e-17
gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens] 89 1e-17
gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens] 89 1e-17
gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens] 89 1e-17
gi|83627721 NIMA-related kinase 5 [Homo sapiens] 89 1e-17
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 88 3e-17
gi|38327572 serine/threonine protein kinase 6 [Homo sapiens] 86 2e-16
gi|38327570 serine/threonine protein kinase 6 [Homo sapiens] 86 2e-16
gi|38327568 serine/threonine protein kinase 6 [Homo sapiens] 86 2e-16
gi|38327566 serine/threonine protein kinase 6 [Homo sapiens] 86 2e-16
gi|38327564 serine/threonine protein kinase 6 [Homo sapiens] 86 2e-16
gi|38327562 serine/threonine protein kinase 6 [Homo sapiens] 86 2e-16
gi|83776600 aurora kinase B [Homo sapiens] 84 6e-16
gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens] 83 8e-16
gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens] 83 8e-16
gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens] 83 8e-16
gi|32455269 serine/threonine kinase 32C [Homo sapiens] 83 8e-16
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 83 1e-15
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 82 1e-15
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 82 2e-15
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 81 3e-15
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 81 4e-15
>gi|207029299 NIMA-related kinase 10 isoform 3 [Homo sapiens]
Length = 712
Score = 1411 bits (3653), Expect = 0.0
Identities = 712/712 (100%), Positives = 712/712 (100%)
Query: 1 MPDQDKKVKTTEKSTDKQQEITIRDYSDLKRLRCLLNVQSSKQQLPAINFDSAQNSMTKS 60
MPDQDKKVKTTEKSTDKQQEITIRDYSDLKRLRCLLNVQSSKQQLPAINFDSAQNSMTKS
Sbjct: 1 MPDQDKKVKTTEKSTDKQQEITIRDYSDLKRLRCLLNVQSSKQQLPAINFDSAQNSMTKS 60
Query: 61 EPAIRAGGHRARGQWHESTEAVELENFSINYKNERNFSKHPQRKLFQEIFTALVKNRLIS 120
EPAIRAGGHRARGQWHESTEAVELENFSINYKNERNFSKHPQRKLFQEIFTALVKNRLIS
Sbjct: 61 EPAIRAGGHRARGQWHESTEAVELENFSINYKNERNFSKHPQRKLFQEIFTALVKNRLIS 120
Query: 121 REWVNRAPSIHFLRVLICLRLLMRDPCYQEILHSLGGIENLAQYMEIVANEYLGYGEEQH 180
REWVNRAPSIHFLRVLICLRLLMRDPCYQEILHSLGGIENLAQYMEIVANEYLGYGEEQH
Sbjct: 121 REWVNRAPSIHFLRVLICLRLLMRDPCYQEILHSLGGIENLAQYMEIVANEYLGYGEEQH 180
Query: 181 TVDKLVNMTYIFQKLAAVKDQREWVTTSGAHKTLVNLLGARDTNVLLGSLLALASLAESQ 240
TVDKLVNMTYIFQKLAAVKDQREWVTTSGAHKTLVNLLGARDTNVLLGSLLALASLAESQ
Sbjct: 181 TVDKLVNMTYIFQKLAAVKDQREWVTTSGAHKTLVNLLGARDTNVLLGSLLALASLAESQ 240
Query: 241 ECREKISELNIVENLLMILHEYDLLSKRLTAELLRLLCAEPQVKEQVKLYEGIPVLLSLL 300
ECREKISELNIVENLLMILHEYDLLSKRLTAELLRLLCAEPQVKEQVKLYEGIPVLLSLL
Sbjct: 241 ECREKISELNIVENLLMILHEYDLLSKRLTAELLRLLCAEPQVKEQVKLYEGIPVLLSLL 300
Query: 301 HSDHLKLLWSIVWILVQVCEDPETSVEIRIWGGIKQLLHILQGDRNFVSDHSSIGSLSSA 360
HSDHLKLLWSIVWILVQVCEDPETSVEIRIWGGIKQLLHILQGDRNFVSDHSSIGSLSSA
Sbjct: 301 HSDHLKLLWSIVWILVQVCEDPETSVEIRIWGGIKQLLHILQGDRNFVSDHSSIGSLSSA 360
Query: 361 NAAGRIQQLHLSEDLSPREIQENTFSLQAACCAALTELVLNDTNAHQVVQENGVYTIAKL 420
NAAGRIQQLHLSEDLSPREIQENTFSLQAACCAALTELVLNDTNAHQVVQENGVYTIAKL
Sbjct: 361 NAAGRIQQLHLSEDLSPREIQENTFSLQAACCAALTELVLNDTNAHQVVQENGVYTIAKL 420
Query: 421 ILPNKQKNAAKSNLLQCYAFRALRFLFSMERNRPLFKRLFPTDLFEIFIDIGHYVRDISA 480
ILPNKQKNAAKSNLLQCYAFRALRFLFSMERNRPLFKRLFPTDLFEIFIDIGHYVRDISA
Sbjct: 421 ILPNKQKNAAKSNLLQCYAFRALRFLFSMERNRPLFKRLFPTDLFEIFIDIGHYVRDISA 480
Query: 481 YEELVSKLNLLVEDELKQIAENIESINQNKAPLKYIGNYAILDHLGSGAFGCVYKVRKHS 540
YEELVSKLNLLVEDELKQIAENIESINQNKAPLKYIGNYAILDHLGSGAFGCVYKVRKHS
Sbjct: 481 YEELVSKLNLLVEDELKQIAENIESINQNKAPLKYIGNYAILDHLGSGAFGCVYKVRKHS 540
Query: 541 GQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLENDRL 600
GQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLENDRL
Sbjct: 541 GQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLENDRL 600
Query: 601 YIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNN 660
YIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNN
Sbjct: 601 YIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNN 660
Query: 661 IMLGDKDKVTVTDFGLAKQKQENSKLTSVVGTILYSCVQHLYLRSPAPALAT 712
IMLGDKDKVTVTDFGLAKQKQENSKLTSVVGTILYSCVQHLYLRSPAPALAT
Sbjct: 661 IMLGDKDKVTVTDFGLAKQKQENSKLTSVVGTILYSCVQHLYLRSPAPALAT 712
>gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]
Length = 347
Score = 96.7 bits (239), Expect = 7e-20
Identities = 56/188 (29%), Positives = 99/188 (52%), Gaps = 10/188 (5%)
Query: 516 IGNYAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSEL 575
+ ++ I +G G F VYK + +A+K+V + K ++D V E+
Sbjct: 76 LADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQD-------CVKEI 128
Query: 576 TIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIF 635
++K QL HPNI++Y +F+E++ L IV+EL + L + K++ E +WK F
Sbjct: 129 GLLK-QLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYF 187
Query: 636 IQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAK-QKQENSKLTSVVGTIL 694
+QLC A+ ++H +R++HRD+ P N+ + V + D GL + E + S+VGT
Sbjct: 188 VQLCSAVEHMH-SRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPY 246
Query: 695 YSCVQHLY 702
Y + ++
Sbjct: 247 YMSPERIH 254
>gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]
Length = 313
Score = 96.7 bits (239), Expect = 7e-20
Identities = 56/188 (29%), Positives = 99/188 (52%), Gaps = 10/188 (5%)
Query: 516 IGNYAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSEL 575
+ ++ I +G G F VYK + +A+K+V + K ++D V E+
Sbjct: 42 LADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQD-------CVKEI 94
Query: 576 TIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIF 635
++K QL HPNI++Y +F+E++ L IV+EL + L + K++ E +WK F
Sbjct: 95 GLLK-QLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYF 153
Query: 636 IQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAK-QKQENSKLTSVVGTIL 694
+QLC A+ ++H +R++HRD+ P N+ + V + D GL + E + S+VGT
Sbjct: 154 VQLCSAVEHMH-SRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPY 212
Query: 695 YSCVQHLY 702
Y + ++
Sbjct: 213 YMSPERIH 220
>gi|4505373 NIMA-related kinase 2 [Homo sapiens]
Length = 445
Score = 96.3 bits (238), Expect = 9e-20
Identities = 61/185 (32%), Positives = 99/185 (53%), Gaps = 16/185 (8%)
Query: 518 NYAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTI 577
+Y +L +G+G++G K+R+ S +L KE++ + ++ + +VSE+ +
Sbjct: 7 DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMT--------EAEKQMLVSEVNL 58
Query: 578 IKEQLYHPNIVRYYKTFLE--NDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIF 635
++E L HPNIVRYY ++ N LYIVME EG L + ++ + EE + ++
Sbjct: 59 LRE-LKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVM 117
Query: 636 IQLCLALRYLHKEK----RIVHRDLTPNNIMLGDKDKVTVTDFGLAK-QKQENSKLTSVV 690
QL LAL+ H+ ++HRDL P N+ L K V + DFGLA+ + S + V
Sbjct: 118 TQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFV 177
Query: 691 GTILY 695
GT Y
Sbjct: 178 GTPYY 182
>gi|19424132 NIMA-related kinase 7 [Homo sapiens]
Length = 302
Score = 95.5 bits (236), Expect = 2e-19
Identities = 55/188 (29%), Positives = 98/188 (52%), Gaps = 10/188 (5%)
Query: 516 IGNYAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSEL 575
+ N+ I +G G F VY+ +A+K+V + + K + D + E+
Sbjct: 31 LANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARAD-------CIKEI 83
Query: 576 TIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIF 635
++K QL HPN+++YY +F+E++ L IV+EL + L K++ E +WK F
Sbjct: 84 DLLK-QLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYF 142
Query: 636 IQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAK-QKQENSKLTSVVGTIL 694
+QLC AL ++H +R++HRD+ P N+ + V + D GL + + + S+VGT
Sbjct: 143 VQLCSALEHMH-SRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPY 201
Query: 695 YSCVQHLY 702
Y + ++
Sbjct: 202 YMSPERIH 209
>gi|163310763 serine/threonine kinase 32A isoform 1 [Homo sapiens]
Length = 396
Score = 95.5 bits (236), Expect = 2e-19
Identities = 58/178 (32%), Positives = 101/178 (56%), Gaps = 13/178 (7%)
Query: 518 NYAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTI 577
++ IL +G G+FG V V+K+ + + AMK +N K K + VRN+ EL I
Sbjct: 22 HFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMN-------KQKCVERNEVRNVFKELQI 74
Query: 578 IKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIFIQ 637
+ + L HP +V + +F + + +++V++L+ G L H +++ HF EE + +
Sbjct: 75 M-QGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHL----QQNVHFKEETVKLFICE 129
Query: 638 LCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQKQENSKLTSVVGTILY 695
L +AL YL + RI+HRD+ P+NI+L + V +TDF +A +++T++ GT Y
Sbjct: 130 LVMALDYLQNQ-RIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPY 186
>gi|41872673 NIMA-related kinase 1 [Homo sapiens]
Length = 1258
Score = 92.4 bits (228), Expect = 1e-18
Identities = 57/178 (32%), Positives = 96/178 (53%), Gaps = 13/178 (7%)
Query: 519 YAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTII 578
Y L +G G+FG V+ +KE+N+ + K+R+ S R + +
Sbjct: 4 YVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMS----SKEREESRREVA-----V 54
Query: 579 KEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIFIQL 638
+ HPNIV+Y ++F EN LYIVM+ EG L + ++ +K F E+++ F+Q+
Sbjct: 55 LANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINA--QKGVLFQEDQILDWFVQI 112
Query: 639 CLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQKQENSKLT-SVVGTILY 695
CLAL+++H +++I+HRD+ NI L V + DFG+A+ +L + +GT Y
Sbjct: 113 CLALKHVH-DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYY 169
>gi|8923754 serine/threonine kinase 32B [Homo sapiens]
Length = 414
Score = 89.7 bits (221), Expect = 8e-18
Identities = 58/178 (32%), Positives = 97/178 (54%), Gaps = 13/178 (7%)
Query: 518 NYAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTI 577
++ IL +G G+FG V V+K + + AMK +N K K VRN+ EL I
Sbjct: 22 HFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMN-------KQKCIERDEVRNVFRELQI 74
Query: 578 IKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIFIQ 637
+ + L HP +V + +F + + +++V++L+ G L H +++ HFTE + +
Sbjct: 75 M-QGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHL----QQNVHFTEGTVKLYICE 129
Query: 638 LCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQKQENSKLTSVVGTILY 695
L LAL YL + I+HRD+ P+NI+L + V +TDF +A + + +S+ GT Y
Sbjct: 130 LALALEYLQRY-HIIHRDIKPDNILLDEHGHVHITDFNIATVVKGAERASSMAGTKPY 186
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 89.4 bits (220), Expect = 1e-17
Identities = 63/178 (35%), Positives = 96/178 (53%), Gaps = 16/178 (8%)
Query: 519 YAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTII 578
Y +L+ +G G+FG VYK R+ ++A+K + P G+ +K+ +RN+ E+ I+
Sbjct: 4 YHVLEMIGEGSFGRVYKGRRKYSAQVVALKFI----PKLGRSEKE----LRNLQREIEIM 55
Query: 579 KEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIFIQL 638
+ L HPNIV +F + + +V + EG E F L E E+++ I QL
Sbjct: 56 RG-LRHPNIVHMLDSFETDKEVVVVTDYAEG----ELFQIL-EDDGKLPEDQVQAIAAQL 109
Query: 639 CLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQKQENSK-LTSVVGTILY 695
AL YLH RI+HRD+ P NI+L + + DFG A+ N+ LTS+ GT LY
Sbjct: 110 VSALYYLHSH-RILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLY 166
>gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]
Length = 489
Score = 89.0 bits (219), Expect = 1e-17
Identities = 54/161 (33%), Positives = 83/161 (51%), Gaps = 13/161 (8%)
Query: 518 NYAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTI 577
+Y +L +G G+FG V+ S + AMKE+ L +F + R +V
Sbjct: 3 DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAV--------- 52
Query: 578 IKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIFIQ 637
+ ++ HPNIV + ++F LYIVME +G L + K K F E+ + F Q
Sbjct: 53 LLAKMKHPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGK--LFPEDMILNWFTQ 110
Query: 638 LCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAK 678
+CL + ++HK KR++HRD+ NI L KV + DFG A+
Sbjct: 111 MCLGVNHIHK-KRVLHRDIKSKNIFLTQNGKVKLGDFGSAR 150
>gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 89.0 bits (219), Expect = 1e-17
Identities = 54/161 (33%), Positives = 83/161 (51%), Gaps = 13/161 (8%)
Query: 518 NYAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTI 577
+Y +L +G G+FG V+ S + AMKE+ L +F + R +V
Sbjct: 3 DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAV--------- 52
Query: 578 IKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIFIQ 637
+ ++ HPNIV + ++F LYIVME +G L + K K F E+ + F Q
Sbjct: 53 LLAKMKHPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGK--LFPEDMILNWFTQ 110
Query: 638 LCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAK 678
+CL + ++HK KR++HRD+ NI L KV + DFG A+
Sbjct: 111 MCLGVNHIHK-KRVLHRDIKSKNIFLTQNGKVKLGDFGSAR 150
>gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 89.0 bits (219), Expect = 1e-17
Identities = 54/161 (33%), Positives = 83/161 (51%), Gaps = 13/161 (8%)
Query: 518 NYAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTI 577
+Y +L +G G+FG V+ S + AMKE+ L +F + R +V
Sbjct: 3 DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAV--------- 52
Query: 578 IKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIFIQ 637
+ ++ HPNIV + ++F LYIVME +G L + K K F E+ + F Q
Sbjct: 53 LLAKMKHPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGK--LFPEDMILNWFTQ 110
Query: 638 LCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAK 678
+CL + ++HK KR++HRD+ NI L KV + DFG A+
Sbjct: 111 MCLGVNHIHK-KRVLHRDIKSKNIFLTQNGKVKLGDFGSAR 150
>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
Length = 708
Score = 89.0 bits (219), Expect = 1e-17
Identities = 53/179 (29%), Positives = 100/179 (55%), Gaps = 14/179 (7%)
Query: 519 YAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTII 578
Y ++ +G GAFG Y + S +KE+N +++++S + + I+
Sbjct: 4 YDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPI----QEKEASKKEV-----IL 54
Query: 579 KEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIFIQL 638
E++ HPNIV ++ +F EN RL+IVME +G L + + +++ F+E+++ F+Q+
Sbjct: 55 LEKMKHPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRIN--RQRGVLFSEDQILGWFVQI 112
Query: 639 CLALRYLHKEKRIVHRDLTPNNIMLGDKDKVT-VTDFGLAKQKQENSKLT-SVVGTILY 695
L L+++H +++I+HRD+ NI L V + DFG+A+ + +L + +GT Y
Sbjct: 113 SLGLKHIH-DRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYY 170
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 87.8 bits (216), Expect = 3e-17
Identities = 61/173 (35%), Positives = 93/173 (53%), Gaps = 15/173 (8%)
Query: 525 LGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTIIKEQLYH 584
+G GAFG V+ + + Q L+ +K++ P K++R ++ +E ++K L H
Sbjct: 10 VGRGAFGIVHLCLRKADQKLVIIKQI----PVEQMTKEERQAAQ----NECQVLK-LLNH 60
Query: 585 PNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIFIQLCLALRY 644
PN++ YY+ FLE+ L I ME G L E K + EE + F+Q+ LAL +
Sbjct: 61 PNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQ--KRCNSLLEEETILHFFVQILLALHH 118
Query: 645 LHKEKRIVHRDLTPNNIMLGDKDK--VTVTDFGLAKQKQENSKLTSVVGTILY 695
+H I+HRDL NI+L DK + V + DFG++K SK +VVGT Y
Sbjct: 119 VHTH-LILHRDLKTQNILL-DKHRMVVKIGDFGISKILSSKSKAYTVVGTPCY 169
>gi|38327572 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 85.5 bits (210), Expect = 2e-16
Identities = 65/203 (32%), Positives = 104/203 (51%), Gaps = 18/203 (8%)
Query: 493 EDELKQIAENIESINQNKAPLKYIGNYAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNL 552
E+EL +N ES + A + ++ I LG G FG VY R+ + +LA+K +
Sbjct: 111 EEELASKQKNEESKKRQWA----LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFK 166
Query: 553 HNPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPL 612
+K + +R V I+ L HPNI+R Y F + R+Y+++E APL
Sbjct: 167 AQ----LEKAGVEHQLRREVE----IQSHLRHPNILRLYGYFHDATRVYLILEY---APL 215
Query: 613 GEHFSSLKEKHHHFTEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVT 672
G + L +K F E+R +L AL Y H KR++HRD+ P N++LG ++ +
Sbjct: 216 GTVYREL-QKLSKFDEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLGSAGELKIA 273
Query: 673 DFGLAKQKQENSKLTSVVGTILY 695
DFG + +S+ T++ GT+ Y
Sbjct: 274 DFGWSVH-APSSRRTTLCGTLDY 295
>gi|38327570 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 85.5 bits (210), Expect = 2e-16
Identities = 65/203 (32%), Positives = 104/203 (51%), Gaps = 18/203 (8%)
Query: 493 EDELKQIAENIESINQNKAPLKYIGNYAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNL 552
E+EL +N ES + A + ++ I LG G FG VY R+ + +LA+K +
Sbjct: 111 EEELASKQKNEESKKRQWA----LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFK 166
Query: 553 HNPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPL 612
+K + +R V I+ L HPNI+R Y F + R+Y+++E APL
Sbjct: 167 AQ----LEKAGVEHQLRREVE----IQSHLRHPNILRLYGYFHDATRVYLILEY---APL 215
Query: 613 GEHFSSLKEKHHHFTEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVT 672
G + L +K F E+R +L AL Y H KR++HRD+ P N++LG ++ +
Sbjct: 216 GTVYREL-QKLSKFDEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLGSAGELKIA 273
Query: 673 DFGLAKQKQENSKLTSVVGTILY 695
DFG + +S+ T++ GT+ Y
Sbjct: 274 DFGWSVH-APSSRRTTLCGTLDY 295
>gi|38327568 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 85.5 bits (210), Expect = 2e-16
Identities = 65/203 (32%), Positives = 104/203 (51%), Gaps = 18/203 (8%)
Query: 493 EDELKQIAENIESINQNKAPLKYIGNYAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNL 552
E+EL +N ES + A + ++ I LG G FG VY R+ + +LA+K +
Sbjct: 111 EEELASKQKNEESKKRQWA----LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFK 166
Query: 553 HNPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPL 612
+K + +R V I+ L HPNI+R Y F + R+Y+++E APL
Sbjct: 167 AQ----LEKAGVEHQLRREVE----IQSHLRHPNILRLYGYFHDATRVYLILEY---APL 215
Query: 613 GEHFSSLKEKHHHFTEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVT 672
G + L +K F E+R +L AL Y H KR++HRD+ P N++LG ++ +
Sbjct: 216 GTVYREL-QKLSKFDEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLGSAGELKIA 273
Query: 673 DFGLAKQKQENSKLTSVVGTILY 695
DFG + +S+ T++ GT+ Y
Sbjct: 274 DFGWSVH-APSSRRTTLCGTLDY 295
>gi|38327566 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 85.5 bits (210), Expect = 2e-16
Identities = 65/203 (32%), Positives = 104/203 (51%), Gaps = 18/203 (8%)
Query: 493 EDELKQIAENIESINQNKAPLKYIGNYAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNL 552
E+EL +N ES + A + ++ I LG G FG VY R+ + +LA+K +
Sbjct: 111 EEELASKQKNEESKKRQWA----LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFK 166
Query: 553 HNPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPL 612
+K + +R V I+ L HPNI+R Y F + R+Y+++E APL
Sbjct: 167 AQ----LEKAGVEHQLRREVE----IQSHLRHPNILRLYGYFHDATRVYLILEY---APL 215
Query: 613 GEHFSSLKEKHHHFTEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVT 672
G + L +K F E+R +L AL Y H KR++HRD+ P N++LG ++ +
Sbjct: 216 GTVYREL-QKLSKFDEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLGSAGELKIA 273
Query: 673 DFGLAKQKQENSKLTSVVGTILY 695
DFG + +S+ T++ GT+ Y
Sbjct: 274 DFGWSVH-APSSRRTTLCGTLDY 295
>gi|38327564 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 85.5 bits (210), Expect = 2e-16
Identities = 65/203 (32%), Positives = 104/203 (51%), Gaps = 18/203 (8%)
Query: 493 EDELKQIAENIESINQNKAPLKYIGNYAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNL 552
E+EL +N ES + A + ++ I LG G FG VY R+ + +LA+K +
Sbjct: 111 EEELASKQKNEESKKRQWA----LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFK 166
Query: 553 HNPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPL 612
+K + +R V I+ L HPNI+R Y F + R+Y+++E APL
Sbjct: 167 AQ----LEKAGVEHQLRREVE----IQSHLRHPNILRLYGYFHDATRVYLILEY---APL 215
Query: 613 GEHFSSLKEKHHHFTEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVT 672
G + L +K F E+R +L AL Y H KR++HRD+ P N++LG ++ +
Sbjct: 216 GTVYREL-QKLSKFDEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLGSAGELKIA 273
Query: 673 DFGLAKQKQENSKLTSVVGTILY 695
DFG + +S+ T++ GT+ Y
Sbjct: 274 DFGWSVH-APSSRRTTLCGTLDY 295
>gi|38327562 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 85.5 bits (210), Expect = 2e-16
Identities = 65/203 (32%), Positives = 104/203 (51%), Gaps = 18/203 (8%)
Query: 493 EDELKQIAENIESINQNKAPLKYIGNYAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNL 552
E+EL +N ES + A + ++ I LG G FG VY R+ + +LA+K +
Sbjct: 111 EEELASKQKNEESKKRQWA----LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFK 166
Query: 553 HNPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPL 612
+K + +R V I+ L HPNI+R Y F + R+Y+++E APL
Sbjct: 167 AQ----LEKAGVEHQLRREVE----IQSHLRHPNILRLYGYFHDATRVYLILEY---APL 215
Query: 613 GEHFSSLKEKHHHFTEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVT 672
G + L +K F E+R +L AL Y H KR++HRD+ P N++LG ++ +
Sbjct: 216 GTVYREL-QKLSKFDEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLGSAGELKIA 273
Query: 673 DFGLAKQKQENSKLTSVVGTILY 695
DFG + +S+ T++ GT+ Y
Sbjct: 274 DFGWSVH-APSSRRTTLCGTLDY 295
>gi|83776600 aurora kinase B [Homo sapiens]
Length = 344
Score = 83.6 bits (205), Expect = 6e-16
Identities = 53/160 (33%), Positives = 86/160 (53%), Gaps = 13/160 (8%)
Query: 516 IGNYAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSEL 575
I ++ I LG G FG VY R+ ++A+K K + +++ + E+
Sbjct: 74 IDDFEIGRPLGKGKFGNVYLAREKKSHFIVALK-------VLFKSQIEKEGVEHQLRREI 126
Query: 576 TIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIF 635
I + L+HPNI+R Y F + R+Y+++E AP GE + L +K F E+R I
Sbjct: 127 EI-QAHLHHPNILRLYNYFYDRRRIYLILEY---APRGELYKEL-QKSCTFDEQRTATIM 181
Query: 636 IQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFG 675
+L AL Y H K+++HRD+ P N++LG K ++ + DFG
Sbjct: 182 EELADALMYCHG-KKVIHRDIKPENLLLGLKGELKIADFG 220
>gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens]
Length = 470
Score = 83.2 bits (204), Expect = 8e-16
Identities = 56/181 (30%), Positives = 96/181 (53%), Gaps = 15/181 (8%)
Query: 519 YAILDHLGSGAFGCVYKV---RKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSEL 575
Y + LGSG+FG VY V + G+ L +KE+++ + ++ N+ ++L
Sbjct: 29 YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVG------ELNPNETVQANLEAQL 82
Query: 576 TIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIF 635
+L HP IV+++ +F+E D I+ E EG L + K+ F E ++ + F
Sbjct: 83 L---SKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWF 139
Query: 636 IQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQKQENSKL-TSVVGTIL 694
IQL L + Y+H E+RI+HRDL N+ L + + + DFG+++ + L T++ GT
Sbjct: 140 IQLLLGVDYMH-ERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPH 197
Query: 695 Y 695
Y
Sbjct: 198 Y 198
>gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens]
Length = 599
Score = 83.2 bits (204), Expect = 8e-16
Identities = 56/181 (30%), Positives = 96/181 (53%), Gaps = 15/181 (8%)
Query: 519 YAILDHLGSGAFGCVYKV---RKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSEL 575
Y + LGSG+FG VY V + G+ L +KE+++ + ++ N+ ++L
Sbjct: 29 YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVG------ELNPNETVQANLEAQL 82
Query: 576 TIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIF 635
+L HP IV+++ +F+E D I+ E EG L + K+ F E ++ + F
Sbjct: 83 L---SKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWF 139
Query: 636 IQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQKQENSKL-TSVVGTIL 694
IQL L + Y+H E+RI+HRDL N+ L + + + DFG+++ + L T++ GT
Sbjct: 140 IQLLLGVDYMH-ERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPH 197
Query: 695 Y 695
Y
Sbjct: 198 Y 198
>gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens]
Length = 645
Score = 83.2 bits (204), Expect = 8e-16
Identities = 56/181 (30%), Positives = 96/181 (53%), Gaps = 15/181 (8%)
Query: 519 YAILDHLGSGAFGCVYKV---RKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSEL 575
Y + LGSG+FG VY V + G+ L +KE+++ + ++ N+ ++L
Sbjct: 29 YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVG------ELNPNETVQANLEAQL 82
Query: 576 TIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIF 635
+L HP IV+++ +F+E D I+ E EG L + K+ F E ++ + F
Sbjct: 83 L---SKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWF 139
Query: 636 IQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQKQENSKL-TSVVGTIL 694
IQL L + Y+H E+RI+HRDL N+ L + + + DFG+++ + L T++ GT
Sbjct: 140 IQLLLGVDYMH-ERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPH 197
Query: 695 Y 695
Y
Sbjct: 198 Y 198
>gi|32455269 serine/threonine kinase 32C [Homo sapiens]
Length = 486
Score = 83.2 bits (204), Expect = 8e-16
Identities = 52/178 (29%), Positives = 99/178 (55%), Gaps = 13/178 (7%)
Query: 518 NYAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTI 577
++ IL +G G+FG V V+K + + AMK +N K + VRN+ EL I
Sbjct: 92 HFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMN-------KQQCIERDEVRNVFRELEI 144
Query: 578 IKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIFIQ 637
++E + H +V + +F + + +++V++L+ G L H +++ F+E+ + +
Sbjct: 145 LQE-IEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHL----QQNVQFSEDTVRLYICE 199
Query: 638 LCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQKQENSKLTSVVGTILY 695
+ LAL YL + + I+HRD+ P+NI+L ++ +TDF +A ++ + T++ GT Y
Sbjct: 200 MALALDYL-RGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPY 256
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 82.8 bits (203), Expect = 1e-15
Identities = 62/177 (35%), Positives = 96/177 (54%), Gaps = 20/177 (11%)
Query: 519 YAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTII 578
+ ++ LGSGAF V+ V++ L A+K + +PAF RDSS+ N ++ L I
Sbjct: 23 FIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIK-KSPAF------RDSSLENEIAVLKKI 75
Query: 579 KEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIFIQL 638
K H NIV + Y+VM+L+ G GE F + E+ +TE+ + Q+
Sbjct: 76 K----HENIVTLEDIYESTTHYYLVMQLVSG---GELFDRILER-GVYTEKDASLVIQQV 127
Query: 639 CLALRYLHKEKRIVHRDLTPNNIML---GDKDKVTVTDFGLAKQKQENSKLTSVVGT 692
A++YLH E IVHRDL P N++ + K+ +TDFGL+K +Q N +++ GT
Sbjct: 128 LSAVKYLH-ENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQ-NGIMSTACGT 182
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 82.4 bits (202), Expect = 1e-15
Identities = 75/245 (30%), Positives = 118/245 (48%), Gaps = 30/245 (12%)
Query: 464 LFEIFIDIGHYVRDISAYEELVSKLNLLVEDELKQIAENIESINQNKAPLKYI------- 516
L E++ I +I EE LNL VE + AE E + + ++
Sbjct: 6 LLELWKKIEVEPMEIETTEE---DLNLDVEPTTEDTAEEEEGVVKEIDISHHVKEGFEKA 62
Query: 517 --GNYAILDHLGSGAFGCVYKVRKHSGQN---LLAMKEVNLHNPAFGKDKKDRDSSVRNI 571
+ +L LG G++G V+ VRK G + L AMK L + R R+I
Sbjct: 63 DPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKV--LKKATLKVRDRVRSKMERDI 120
Query: 572 VSELTIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERL 631
++E+ HP IV+ + F +LY++++ + G G+ F+ L K FTEE +
Sbjct: 121 LAEVN-------HPFIVKLHYAFQTEGKLYLILDFLRG---GDLFTRLS-KEVMFTEEDV 169
Query: 632 WKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQKQENSKLT-SVV 690
+L LAL +LH I++RDL P NI+L ++ + +TDFGL+K+ ++ K S
Sbjct: 170 KFYLAELALALDHLHS-LGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFC 228
Query: 691 GTILY 695
GTI Y
Sbjct: 229 GTIEY 233
Score = 62.8 bits (151), Expect = 1e-09
Identities = 46/178 (25%), Positives = 79/178 (44%), Gaps = 23/178 (12%)
Query: 513 LKYIGNYAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIV 572
+ + Y I + +G G++ + + A+K + DK RD S
Sbjct: 417 IHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKII---------DKSKRDPS----- 462
Query: 573 SELTIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLW 632
E+ I+ HPNI+ + + +Y+VMEL+ G L + + +F+E
Sbjct: 463 EEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRIL----RQRYFSEREAS 518
Query: 633 KIFIQLCLALRYLHKEKRIVHRDLTPNNIML----GDKDKVTVTDFGLAKQKQENSKL 686
+ + + YLH + +VHRDL P+NI+ G + + V DFG AKQ + + L
Sbjct: 519 DVLCTITKTMDYLHSQ-GVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGL 575
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 81.6 bits (200), Expect = 2e-15
Identities = 67/200 (33%), Positives = 102/200 (51%), Gaps = 21/200 (10%)
Query: 503 IESINQNKAPLKYIGN-YAILDHLGSGAFGCVYKVRKHSGQN---LLAMKEVNLHNPAFG 558
I + N+ P K + +L LG G +G V++VRK +G N + AMK L
Sbjct: 74 ISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKV--LKKAMIV 131
Query: 559 KDKKD--RDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHF 616
++ KD + RNI+ E++ HP IV F +LY+++E + G GE F
Sbjct: 132 RNAKDTAHTKAERNIL-------EEVKHPFIVDLIYAFQTGGKLYLILEYLSG---GELF 181
Query: 617 SSLKEKHHHFTEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGL 676
L E+ F E+ ++ +AL +LH +K I++RDL P NIML + V +TDFGL
Sbjct: 182 MQL-EREGIFMEDTACFYLAEISMALGHLH-QKGIIYRDLKPENIMLNHQGHVKLTDFGL 239
Query: 677 AKQKQENSKLT-SVVGTILY 695
K+ + +T + GTI Y
Sbjct: 240 CKESIHDGTVTHTFCGTIEY 259
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 81.3 bits (199), Expect = 3e-15
Identities = 61/181 (33%), Positives = 96/181 (53%), Gaps = 18/181 (9%)
Query: 519 YAILDHLGSGAFGCVYKVRKHSGQN---LLAMKEVNLHNPAFGKDKKDRDSSVRNIVSEL 575
+ +L LG G++G V+ VRK G + L AMK L + R R+I++E+
Sbjct: 59 FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKV--LKKATLKVRDRVRSKMERDILAEV 116
Query: 576 TIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIF 635
HP IV+ + F +LY++++ + G G+ F+ L K FTEE +
Sbjct: 117 N-------HPFIVKLHYAFQTEGKLYLILDFLRG---GDLFTRLS-KEVMFTEEDVKFYL 165
Query: 636 IQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQKQENSKLT-SVVGTIL 694
+L LAL +LH I++RDL P NI+L ++ + +TDFGL+K+ ++ K S GTI
Sbjct: 166 AELALALDHLHS-LGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIE 224
Query: 695 Y 695
Y
Sbjct: 225 Y 225
Score = 62.8 bits (151), Expect = 1e-09
Identities = 46/178 (25%), Positives = 79/178 (44%), Gaps = 23/178 (12%)
Query: 513 LKYIGNYAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIV 572
+ + Y I + +G G++ + + A+K + DK RD S
Sbjct: 409 IHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKII---------DKSKRDPS----- 454
Query: 573 SELTIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLW 632
E+ I+ HPNI+ + + +Y+VMEL+ G L + + +F+E
Sbjct: 455 EEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRIL----RQRYFSEREAS 510
Query: 633 KIFIQLCLALRYLHKEKRIVHRDLTPNNIML----GDKDKVTVTDFGLAKQKQENSKL 686
+ + + YLH + +VHRDL P+NI+ G + + V DFG AKQ + + L
Sbjct: 511 DVLCTITKTMDYLHSQ-GVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGL 567
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 80.9 bits (198), Expect = 4e-15
Identities = 62/181 (34%), Positives = 96/181 (53%), Gaps = 18/181 (9%)
Query: 519 YAILDHLGSGAFGCVYKVRKHSGQN---LLAMKEVNLHNPAFGKDKKDRDSSVRNIVSEL 575
+ +L LG G+FG V+ VRK +G + L AMK L + + R R+I+ E+
Sbjct: 73 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKV--LKKASLKVRDRVRTKMERDILVEV 130
Query: 576 TIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIF 635
HP IV+ + F +LY++++ + G G+ F+ L K FTEE +
Sbjct: 131 N-------HPFIVKLHYAFQTEGKLYLILDFLRG---GDVFTRLS-KEVLFTEEDVKFYL 179
Query: 636 IQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQK-QENSKLTSVVGTIL 694
+L LAL +LH + IV+RDL P NI+L + + +TDFGL+K+ + K S GT+
Sbjct: 180 AELALALDHLH-QLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVE 238
Query: 695 Y 695
Y
Sbjct: 239 Y 239
Score = 61.2 bits (147), Expect = 3e-09
Identities = 52/165 (31%), Positives = 83/165 (50%), Gaps = 15/165 (9%)
Query: 530 FGCVYKVRKHSGQNLLAMKEVNLH---NPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPN 586
FG VY++++ G ++ + +H N F K D S R+ E+ I+ HPN
Sbjct: 422 FGEVYELKEDIGVGSYSVCKRCIHATTNMEFAV--KIIDKSKRDPSEEIEILMRYGQHPN 479
Query: 587 IVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIFIQLCLALRYLH 646
I+ F + +Y+V +L++G L + LK+K F+E I + + YLH
Sbjct: 480 IITLKDVFDDGRYVYLVTDLMKGGELLDRI--LKQK--CFSEREASDILYVISKTVDYLH 535
Query: 647 KEKRIVHRDLTPNNIMLGDK----DKVTVTDFGLAKQ-KQENSKL 686
+ +VHRDL P+NI+ D+ D + + DFG AKQ + EN L
Sbjct: 536 CQ-GVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLL 579
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.389
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,679,855
Number of Sequences: 37866
Number of extensions: 1022027
Number of successful extensions: 4417
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 483
Number of HSP's successfully gapped in prelim test: 308
Number of HSP's that attempted gapping in prelim test: 2928
Number of HSP's gapped (non-prelim): 928
length of query: 712
length of database: 18,247,518
effective HSP length: 109
effective length of query: 603
effective length of database: 14,120,124
effective search space: 8514434772
effective search space used: 8514434772
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.