Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 20149547
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
(735 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 1486 0.0
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 1418 0.0
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 1191 0.0
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 1174 0.0
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 1163 0.0
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 1087 0.0
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a... 569 e-162
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 541 e-154
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso... 541 e-154
gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b... 436 e-122
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 377 e-104
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 370 e-102
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 295 8e-80
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 295 8e-80
gi|4502023 AKT2 kinase [Homo sapiens] 287 2e-77
gi|62241015 AKT1 kinase [Homo sapiens] 281 1e-75
gi|62241013 AKT1 kinase [Homo sapiens] 281 1e-75
gi|62241011 AKT1 kinase [Homo sapiens] 281 1e-75
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 281 1e-75
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 281 1e-75
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 281 1e-75
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 281 1e-75
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 281 2e-75
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 281 2e-75
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 271 2e-72
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 271 2e-72
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 264 3e-70
gi|4506067 protein kinase C, alpha [Homo sapiens] 259 5e-69
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 258 1e-68
gi|5453974 protein kinase N2 [Homo sapiens] 258 1e-68
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 1486 bits (3846), Expect = 0.0
Identities = 735/735 (100%), Positives = 735/735 (100%)
Query: 1 MPLAQLKEPWPLMELVPLDPENGQTSGEEAGLQPSKDEGVLKEISITHHVKAGSEKADPS 60
MPLAQLKEPWPLMELVPLDPENGQTSGEEAGLQPSKDEGVLKEISITHHVKAGSEKADPS
Sbjct: 1 MPLAQLKEPWPLMELVPLDPENGQTSGEEAGLQPSKDEGVLKEISITHHVKAGSEKADPS 60
Query: 61 HFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVN 120
HFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVN
Sbjct: 61 HFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVN 120
Query: 121 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS 180
HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS
Sbjct: 121 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS 180
Query: 181 LGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHS 240
LGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHS
Sbjct: 181 LGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHS 240
Query: 241 HSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRN 300
HSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRN
Sbjct: 241 HSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRN 300
Query: 301 PANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTP 360
PANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTP
Sbjct: 301 PANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTP 360
Query: 361 KDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVV 420
KDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVV
Sbjct: 361 KDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVV 420
Query: 421 KETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYD 480
KETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYD
Sbjct: 421 KETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYD 480
Query: 481 DGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSN 540
DGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSN
Sbjct: 481 DGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSN 540
Query: 541 ILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSL 600
ILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSL
Sbjct: 541 ILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSL 600
Query: 601 GILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDP 660
GILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDP
Sbjct: 601 GILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDP 660
Query: 661 HQRLTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGAMAATYSALNSSKPTPQLKPIESS 720
HQRLTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGAMAATYSALNSSKPTPQLKPIESS
Sbjct: 661 HQRLTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGAMAATYSALNSSKPTPQLKPIESS 720
Query: 721 ILAQRRVRKLPSTTL 735
ILAQRRVRKLPSTTL
Sbjct: 721 ILAQRRVRKLPSTTL 735
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 1418 bits (3671), Expect = 0.0
Identities = 709/732 (96%), Positives = 712/732 (97%), Gaps = 6/732 (0%)
Query: 10 WPLMELVPLD--PENGQTS----GEEAGLQPSKDEGVLKEISITHHVKAGSEKADPSHFE 63
W L+ +P P QTS G +G Q DEGVLKEISITHHVKAGSEKADPSHFE
Sbjct: 13 WALIPWLPRKQRPRISQTSLPVPGPGSGPQRDSDEGVLKEISITHHVKAGSEKADPSHFE 72
Query: 64 LLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPF 123
LLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPF
Sbjct: 73 LLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPF 132
Query: 124 VVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGI 183
VVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGI
Sbjct: 133 VVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGI 192
Query: 184 IYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSA 243
IYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSA
Sbjct: 193 IYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSA 252
Query: 244 DWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPAN 303
DWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPAN
Sbjct: 253 DWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPAN 312
Query: 304 RLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDS 363
RLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDS
Sbjct: 313 RLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDS 372
Query: 364 PGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVVKET 423
PGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVVKET
Sbjct: 373 PGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVVKET 432
Query: 424 IGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGK 483
IGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGK
Sbjct: 433 IGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGK 492
Query: 484 HVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILY 543
HVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILY
Sbjct: 493 HVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILY 552
Query: 544 VDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGIL 603
VDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGIL
Sbjct: 553 VDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGIL 612
Query: 604 LYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQR 663
LYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQR
Sbjct: 613 LYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQR 672
Query: 664 LTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILA 723
LTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILA
Sbjct: 673 LTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILA 732
Query: 724 QRRVRKLPSTTL 735
QRRVRKLPSTTL
Sbjct: 733 QRRVRKLPSTTL 744
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 1191 bits (3081), Expect = 0.0
Identities = 599/744 (80%), Positives = 654/744 (87%), Gaps = 13/744 (1%)
Query: 1 MPLAQLKEPWPLMELV-PLDP-ENGQT-----SGEEAGLQPSKDEGVLKEISITHHVKAG 53
MPLAQL +PW M + P D ENGQ GEE + P +E +KEI+ITHHVK G
Sbjct: 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEE-INPQTEEVSIKEIAITHHVKEG 59
Query: 54 SEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMER 113
EKADPS FELLKVLGQGSFGKVFLV+K++ D+ LYAMKVLKKATLKVRDRVRTKMER
Sbjct: 60 HEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMER 119
Query: 114 DILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 173
DIL +VNHPF+VKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL
Sbjct: 120 DILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 179
Query: 174 GLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEV 233
LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKE+IDHEKKAYSFCGTVEYMAPEV
Sbjct: 180 ALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEV 239
Query: 234 VNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLL 293
VNR+GH+ SADWWS+GVLMFEMLTG+LPFQGKDRKETMT+ILKAKLGMPQFLS EAQSLL
Sbjct: 240 VNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLL 299
Query: 294 RALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDT 353
R LFKRNPANRLG+GPDG EEIKRH F+STIDWNKLYRREI PPFKPA +P+DTFYFD
Sbjct: 300 RMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDP 359
Query: 354 EFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLV 413
EFT++TPKDSPGIPPSA AHQLFRGFSFVA + DD +HS+VQQLH ++
Sbjct: 360 EFTAKTPKDSPGIPPSANAHQLFRGFSFVA--ITSDDESQAMQTVGVHSIVQQLHRNSIQ 417
Query: 414 FSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNII 473
F+DGY VKE IGVGSYS CKRC+HKATNME+AVK+IDKSKRDP+EEIEILLRYGQHPNII
Sbjct: 418 FTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNII 477
Query: 474 TLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVH 533
TLKDVYDDGK+VY+VTELM+GGELLDKILRQKFFSEREAS VL TI KTVEYLH+QGVVH
Sbjct: 478 TLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVH 537
Query: 534 RDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDE 593
RDLKPSNILYVDESGNPE +RICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYD
Sbjct: 538 RDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDA 597
Query: 594 GCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVS 653
CDIWSLG+LLYTML GYTPFANGP DTPEEIL RIGSGKF+LSGG WN+VS+TAKDLVS
Sbjct: 598 ACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVS 657
Query: 654 KMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDL-QLVKGAMAATYSALNSSKPTP 712
KMLHVDPHQRLTA VL+HPW+ D+LPQ QL+ QD LVKGAMAATYSALN ++ +P
Sbjct: 658 KMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQ-SP 716
Query: 713 QLKPIESSILAQRR-VRKLPSTTL 735
L+P+ S LAQRR ++K+ ST L
Sbjct: 717 VLEPVGRSTLAQRRGIKKITSTAL 740
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 1174 bits (3038), Expect = 0.0
Identities = 580/744 (77%), Positives = 651/744 (87%), Gaps = 12/744 (1%)
Query: 1 MPLAQLKEPWPLMELVPLDPENGQTSGEEAGLQ--------PSKDEGVLKEISITHHVKA 52
MP+AQL E W +E+ P++ E T+ E+ L ++EGV+KEI I+HHVK
Sbjct: 1 MPIAQLLELWKKIEVEPMEIE---TTEEDLNLDVEPTTEDTAEEEEGVVKEIDISHHVKE 57
Query: 53 GSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKME 112
G EKADPS FELLKVLGQGS+GKVFLVRKV D+G LYAMKVLKKATLKVRDRVR+KME
Sbjct: 58 GFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKME 117
Query: 113 RDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 172
RDILA+VNHPF+VKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA
Sbjct: 118 RDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 177
Query: 173 LGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPE 232
L LDHLHSLGIIYRDLKPENILLDEEGHIK+TDFGLSKEAIDH+K+AYSFCGT+EYMAPE
Sbjct: 178 LALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPE 237
Query: 233 VVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSL 292
VVNR+GH+ SADWWS+GVLMFEMLTGSLPFQGKDRKETM LILKAKLGMPQFLS EAQSL
Sbjct: 238 VVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSL 297
Query: 293 LRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFD 352
LRALFKRNP NRLG+G DG EEIKRH F+ TIDWN LYR+EIKPPFKPAV +P+DTF+FD
Sbjct: 298 LRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFD 357
Query: 353 TEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNL 412
EFT+RTP DSPG+PPSA AH LFRGFSFVA+ L+++ + + P+H +VQQLHG N+
Sbjct: 358 PEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNI 417
Query: 413 VFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNI 472
F+DGY +KE IGVGSYS CKRCVHKAT+ EYAVK+IDKSKRDPSEEIEILLRYGQHPNI
Sbjct: 418 HFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNI 477
Query: 473 ITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVV 532
ITLKDVYDDGK VYLV ELMRGGELLD+ILRQ++FSEREAS VL TI KT++YLHSQGVV
Sbjct: 478 ITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVV 537
Query: 533 HRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYD 592
HRDLKPSNILY DESG+PE +R+CDFGFAKQLRA NGLLMTPCYTANFVAPEVLKRQGYD
Sbjct: 538 HRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYD 597
Query: 593 EGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLV 652
CDIWSLGILLYTMLAG+TPFANGP DTPEEIL RIGSGK+ LSGGNW+++S+ AKD+V
Sbjct: 598 AACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVV 657
Query: 653 SKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGAMAATYSALNSSKPTP 712
SKMLHVDPHQRLTA QVL+HPWV ++ L +QLS QD+ LVKGAMAATY ALN + P
Sbjct: 658 SKMLHVDPHQRLTAMQVLKHPWVVNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAP 717
Query: 713 QLKPIESSILAQRR-VRKLPSTTL 735
+L+P+ SS LAQRR +++L ST L
Sbjct: 718 RLEPVLSSNLAQRRGMKRLTSTRL 741
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 1163 bits (3008), Expect = 0.0
Identities = 568/713 (79%), Positives = 636/713 (89%), Gaps = 1/713 (0%)
Query: 24 QTSGEEAGLQPSKDEGVLKEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVT 83
++ + + L ++EGV+KEI I+HHVK G EKADPS FELLKVLGQGS+GKVFLVRKV
Sbjct: 21 KSRSKSSSLSRLEEEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVK 80
Query: 84 RPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDF 143
D+G LYAMKVLKKATLKVRDRVR+KMERDILA+VNHPF+VKLHYAFQTEGKLYLILDF
Sbjct: 81 GSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDF 140
Query: 144 LRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKL 203
LRGGDLFTRLSKEVMFTEEDVKFYLAELAL LDHLHSLGIIYRDLKPENILLDEEGHIK+
Sbjct: 141 LRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKI 200
Query: 204 TDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQ 263
TDFGLSKEAIDH+K+AYSFCGT+EYMAPEVVNR+GH+ SADWWS+GVLMFEMLTGSLPFQ
Sbjct: 201 TDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQ 260
Query: 264 GKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYST 323
GKDRKETM LILKAKLGMPQFLS EAQSLLRALFKRNP NRLG+G DG EEIKRH F+ T
Sbjct: 261 GKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVT 320
Query: 324 IDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVA 383
IDWN LYR+EIKPPFKPAV +P+DTF+FD EFT+RTP DSPG+PPSA AH LFRGFSFVA
Sbjct: 321 IDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVA 380
Query: 384 TGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNME 443
+ L+++ + + P+H +VQQLHG N+ F+DGY +KE IGVGSYS CKRCVHKAT+ E
Sbjct: 381 SSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTE 440
Query: 444 YAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILR 503
YAVK+IDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGK VYLV ELMRGGELLD+ILR
Sbjct: 441 YAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILR 500
Query: 504 QKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQ 563
Q++FSEREAS VL TI KT++YLHSQGVVHRDLKPSNILY DESG+PE +R+CDFGFAKQ
Sbjct: 501 QRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQ 560
Query: 564 LRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPE 623
LRA NGLLMTPCYTANFVAPEVLKRQGYD CDIWSLGILLYTMLAG+TPFANGP DTPE
Sbjct: 561 LRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPE 620
Query: 624 EILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQ 683
EIL RIGSGK+ LSGGNW+++S+ AKD+VSKMLHVDPHQRLTA QVL+HPWV ++ L
Sbjct: 621 EILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYLSP 680
Query: 684 SQLSHQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILAQRR-VRKLPSTTL 735
+QLS QD+ LVKGAMAATY ALN + P+L+P+ SS LAQRR +++L ST L
Sbjct: 681 NQLSRQDVHLVKGAMAATYFALNRTPQAPRLEPVLSSNLAQRRGMKRLTSTRL 733
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 1087 bits (2811), Expect = 0.0
Identities = 541/748 (72%), Positives = 622/748 (83%), Gaps = 20/748 (2%)
Query: 1 MPLAQLKEPWPL-MELVPLDPENGQTSGEEAGLQ------------PSKDEGVLKEISIT 47
+P A EPW ME+ G +SGE GL+ DEGV+KEI IT
Sbjct: 2 LPFAPQDEPWDREMEVFS---GGGASSGEVNGLKMVDEPMEEGEADSCHDEGVVKEIPIT 58
Query: 48 HHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRV 107
HHVK G EKADP+ FELLKVLGQGSFGKVFLVRK T PD+G LYAMKVLKKA+LKVRDRV
Sbjct: 59 HHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRV 118
Query: 108 RTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFY 167
RTKMERDIL +VNHPF+VKLHYAFQTEGKLYLILDFLRGGD+FTRLSKEV+FTEEDVKFY
Sbjct: 119 RTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFY 178
Query: 168 LAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVE 227
LAELAL LDHLH LGI+YRDLKPENILLDE GHIKLTDFGLSKE++D EKKAYSFCGTVE
Sbjct: 179 LAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVE 238
Query: 228 YMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLST 287
YMAPEVVNR+GHS SADWWSYGVLMFEMLTG+LPFQGKDR ETM +ILKAKLGMPQFLS
Sbjct: 239 YMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSA 298
Query: 288 EAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDD 347
EAQSLLR LFKRNPANRLGS +G EEIKRH+F++ IDW+KLY+RE++PPFKPA +PDD
Sbjct: 299 EAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDD 356
Query: 348 TFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQL 407
TF FD EFT++TPKDSPG+P SA AHQLF+GFSFVAT + E+ A + +V Q+
Sbjct: 357 TFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIV-QI 415
Query: 408 HGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYG 467
+G F + Y +KE IGVGSYS CKRC+H TNME+AVK+IDKSKRDPSEEIEIL+RYG
Sbjct: 416 NGNAAQFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYG 475
Query: 468 QHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLH 527
QHPNIITLKDV+DDG++VYLVT+LM+GGELLD+IL+QK FSEREAS +L+ I KTV+YLH
Sbjct: 476 QHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLH 535
Query: 528 SQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK 587
QGVVHRDLKPSNILY+DES + + +RICDFGFAKQLR ENGLL+TPCYTANFVAPEVL
Sbjct: 536 CQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLM 595
Query: 588 RQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSET 647
+QGYD CDIWSLG+L YTMLAGYTPFANGP+DTPEEIL RIG+GKF+LSGGNW+ +S+
Sbjct: 596 QQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDG 655
Query: 648 AKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDL-QLVKGAMAATYSALN 706
AKDL+S MLH+DPHQR TA+Q+L+H W+T +D+LP Q D+ +VKGAM ATYSAL
Sbjct: 656 AKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQPKRNDVSHVVKGAMVATYSALT 715
Query: 707 SSKPTPQLKPIESSILAQRRVRKLPSTT 734
P L+P+ +S LAQRR K ++T
Sbjct: 716 HKTFQPVLEPVAASSLAQRRSMKKRTST 743
>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
[Homo sapiens]
Length = 802
Score = 569 bits (1467), Expect = e-162
Identities = 316/752 (42%), Positives = 455/752 (60%), Gaps = 40/752 (5%)
Query: 21 ENGQTSGEEAGLQPSKDEGVLKEISITHHVKAGS-----EKADPSHFELLKVLGQGSFGK 75
E G +SG AG +G + +++ H ++ + EK +FELLKVLG G++GK
Sbjct: 3 EEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGK 62
Query: 76 VFLVRKVTRPDSGHLYAMKVLKKATL--KVRDRVRTKMERDILADVNH-PFVVKLHYAFQ 132
VFLVRK++ D+G LYAMKVLKKAT+ K + T+ ER +L + PF+V LHYAFQ
Sbjct: 63 VFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQ 122
Query: 133 TEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPEN 192
TE KL+LILD++ GG+LFT LS+ FTE +V+ Y+ E+ L L+HLH LGIIYRD+K EN
Sbjct: 123 TETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLEN 182
Query: 193 ILLDEEGHIKLTDFGLSKEAI-DHEKKAYSFCGTVEYMAPEVV--NRQGHSHSADWWSYG 249
ILLD GH+ LTDFGLSKE + D ++AYSFCGT+EYMAP++V GH + DWWS G
Sbjct: 183 ILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLG 242
Query: 250 VLMFEMLTGSLPF----QGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRL 305
VLM+E+LTG+ PF + + E ILK++ PQ +S A+ L++ L ++P RL
Sbjct: 243 VLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRL 302
Query: 306 GSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPG 365
G GP A+EIK H+F+ I+W+ L +++ PFKP + D F EFT P SP
Sbjct: 303 GCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPA 362
Query: 366 IPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFS---------- 415
P + + +LF+G+SFVA ++ H V++ N+ S
Sbjct: 363 ALPQS-SEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFYQ 421
Query: 416 --DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDK-SKRDPSEEIEILLRYGQHPNI 472
D + + +G GS+S C++CVHK +N +AVK+I K + + +EI L HPNI
Sbjct: 422 HYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNI 481
Query: 473 ITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVV 532
+ L +V+ D H +LV EL+ GGEL ++I ++K FSE EAS+++ + V ++H GVV
Sbjct: 482 VKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVV 541
Query: 533 HRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYD 592
HRDLKP N+L+ DE+ N E ++I DFGFA+ +N L TPC+T ++ APE+L + GYD
Sbjct: 542 HRDLKPENLLFTDENDNLE-IKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYD 600
Query: 593 EGCDIWSLGILLYTMLAGYTPFANGPSD----TPEEILTRIGSGKFTLSGGNWNTVSETA 648
E CD+WSLG++LYTML+G PF + + EI+ +I G F+ G W VS+ A
Sbjct: 601 ESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEA 660
Query: 649 KDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGA-----MAATYS 703
KDL+ +L VDP++RL + + W+ +L + L D+ GA + AT+
Sbjct: 661 KDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFH 720
Query: 704 ALNSSKPTP-QLKPIESSILAQRRVRKLPSTT 734
A N K L+ ++ + LA+RR K ST+
Sbjct: 721 AFNKYKREGFCLQNVDKAPLAKRRKMKKTSTS 752
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
Length = 766
Score = 541 bits (1394), Expect = e-154
Identities = 314/731 (42%), Positives = 436/731 (59%), Gaps = 37/731 (5%)
Query: 37 DEGVLKEISITHHVKAG-SEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKV 95
DE E+ IT G EK +FELLKVLG G++GKVFLVRK D+G LYAMKV
Sbjct: 7 DESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKV 66
Query: 96 LKKATLKVRDRVR--TKMERDILADVNH-PFVVKLHYAFQTEGKLYLILDFLRGGDLFTR 152
L+KA L R + + T+ ER +L V PF+V LHYAFQT+ KL+LILD++ GG++FT
Sbjct: 67 LRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTH 126
Query: 153 LSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEA 212
L + F E +V+ Y E+ L L+HLH LGIIYRDLK EN+LLD EGHI LTDFGLSKE
Sbjct: 127 LYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEF 186
Query: 213 IDHEK-KAYSFCGTVEYMAPEVV-NRQGHSHSADWWSYGVLMFEMLTGSLPF----QGKD 266
+ EK + +SFCGT+EYMAPE++ ++ GH + DWWS G+L+FE+LTG+ PF +
Sbjct: 187 LTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNT 246
Query: 267 RKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDW 326
+ E ILK P + AQ LL+ L ++P RLG+GP GA+E++ H F+ +DW
Sbjct: 247 QAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDW 306
Query: 327 NKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGL 386
L R+I PF+P + D F EFT P SP P G ++F+G+SFVA +
Sbjct: 307 VALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSI 366
Query: 387 MED-------DG--KPRAPQAPLHSVVQQLHGKNLVFSDGYVVKETIGVGSYSECKRCVH 437
+ D DG P A P + V + D + + +G GS+S C+RC
Sbjct: 367 LFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQQYELD--LREPALGQGSFSVCRRCRQ 424
Query: 438 KATNMEYAVKVIDKS-KRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGE 496
+ + E+AVK++ + + + E+ L HPN++ L +V+ D H YLV EL+RGGE
Sbjct: 425 RQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGE 484
Query: 497 LLDKILRQKFFSEREASFVLHTIGKTVEYLHSQ-GVVHRDLKPSNILYVDES-GNPECLR 554
LL+ I +++ FSE EAS +L ++ V ++H + GVVHRDLKP NILY D++ G P ++
Sbjct: 485 LLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAP--VK 542
Query: 555 ICDFGFAKQLRAENGL-LMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTP 613
I DFGFA+ G+ + TPC+T + APE+L +QGYDE CD+WSLG++LY ML+G P
Sbjct: 543 IIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVP 602
Query: 614 F----ANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQV 669
F G EI+ +I G+F+L G W VSE AK+LV +L VDP +RL + +
Sbjct: 603 FQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGL 662
Query: 670 LQHPWVTQKDKLPQSQLSHQDL-----QLVKGAMAATYSALNSSKPTP-QLKPIESSILA 723
W+ L D+ V+ + AT+ A N K LK +E++ LA
Sbjct: 663 RGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLA 722
Query: 724 QRRVRKLPSTT 734
+RR +KL S T
Sbjct: 723 KRRKQKLRSAT 733
>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform a [Homo sapiens]
Length = 772
Score = 541 bits (1394), Expect = e-154
Identities = 315/735 (42%), Positives = 439/735 (59%), Gaps = 39/735 (5%)
Query: 37 DEGVLKEISITHHVKAG-SEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKV 95
DE E+ IT G EK +FELLKVLG G++GKVFLVRK D+G LYAMKV
Sbjct: 7 DESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKV 66
Query: 96 LKKATLKVRDRVR--TKMERDILADVNH-PFVVKLHYAFQTEGKLYLILDFLRGGDLFTR 152
L+KA L R + + T+ ER +L V PF+V LHYAFQT+ KL+LILD++ GG++FT
Sbjct: 67 LRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTH 126
Query: 153 LSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEA 212
L + F E +V+ Y E+ L L+HLH LGIIYRDLK EN+LLD EGHI LTDFGLSKE
Sbjct: 127 LYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEF 186
Query: 213 IDHEK-KAYSFCGTVEYMAPEVV-NRQGHSHSADWWSYGVLMFEMLTGSLPF----QGKD 266
+ EK + +SFCGT+EYMAPE++ ++ GH + DWWS G+L+FE+LTG+ PF +
Sbjct: 187 LTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNT 246
Query: 267 RKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDW 326
+ E ILK P + AQ LL+ L ++P RLG+GP GA+E++ H F+ +DW
Sbjct: 247 QAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDW 306
Query: 327 NKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGL 386
L R+I PF+P + D F EFT P SP P G ++F+G+SFVA +
Sbjct: 307 VALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSI 366
Query: 387 MED-------DG--KPRAPQAP-LHSVVQQLHGKNLVFSDGYVV---KETIGVGSYSECK 433
+ D DG P A P +V + ++ F Y + + +G GS+S C+
Sbjct: 367 LFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALGQGSFSVCR 426
Query: 434 RCVHKATNMEYAVKVIDKS-KRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELM 492
RC + + E+AVK++ + + + E+ L HPN++ L +V+ D H YLV EL+
Sbjct: 427 RCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELL 486
Query: 493 RGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQ-GVVHRDLKPSNILYVDES-GNP 550
RGGELL+ I +++ FSE EAS +L ++ V ++H + GVVHRDLKP NILY D++ G P
Sbjct: 487 RGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAP 546
Query: 551 ECLRICDFGFAKQLRAENGL-LMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLA 609
++I DFGFA+ G+ + TPC+T + APE+L +QGYDE CD+WSLG++LY ML+
Sbjct: 547 --VKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLS 604
Query: 610 GYTPF----ANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLT 665
G PF G EI+ +I G+F+L G W VSE AK+LV +L VDP +RL
Sbjct: 605 GQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLK 664
Query: 666 AKQVLQHPWVTQKDKLPQSQLSHQDL-----QLVKGAMAATYSALNSSKPTP-QLKPIES 719
+ + W+ L D+ V+ + AT+ A N K LK +E+
Sbjct: 665 LEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVEN 724
Query: 720 SILAQRRVRKLPSTT 734
+ LA+RR +KL S T
Sbjct: 725 APLAKRRKQKLRSAT 739
>gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b
[Homo sapiens]
Length = 549
Score = 436 bits (1122), Expect = e-122
Identities = 238/546 (43%), Positives = 337/546 (61%), Gaps = 29/546 (5%)
Query: 21 ENGQTSGEEAGLQPSKDEGVLKEISITHHVKAGS-----EKADPSHFELLKVLGQGSFGK 75
E G +SG AG +G + +++ H ++ + EK +FELLKVLG G++GK
Sbjct: 3 EEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGK 62
Query: 76 VFLVRKVTRPDSGHLYAMKVLKKATL--KVRDRVRTKMERDILADVNH-PFVVKLHYAFQ 132
VFLVRK++ D+G LYAMKVLKKAT+ K + T+ ER +L + PF+V LHYAFQ
Sbjct: 63 VFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQ 122
Query: 133 TEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPEN 192
TE KL+LILD++ GG+LFT LS+ FTE +V+ Y+ E+ L L+HLH LGIIYRD+K EN
Sbjct: 123 TETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLEN 182
Query: 193 ILLDEEGHIKLTDFGLSKEAI-DHEKKAYSFCGTVEYMAPEVV--NRQGHSHSADWWSYG 249
ILLD GH+ LTDFGLSKE + D ++AYSFCGT+EYMAP++V GH + DWWS G
Sbjct: 183 ILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLG 242
Query: 250 VLMFEMLTGSLPF----QGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRL 305
VLM+E+LTG+ PF + + E ILK++ PQ +S A+ L++ L ++P RL
Sbjct: 243 VLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRL 302
Query: 306 GSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPG 365
G GP A+EIK H+F+ I+W+ L +++ PFKP + D F EFT P SP
Sbjct: 303 GCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPA 362
Query: 366 IPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFS---------- 415
P + + +LF+G+SFVA ++ H V++ N+ S
Sbjct: 363 ALPQS-SEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFYQ 421
Query: 416 --DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDK-SKRDPSEEIEILLRYGQHPNI 472
D + + +G GS+S C++CVHK +N +AVK+I K + + +EI L HPNI
Sbjct: 422 HYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNI 481
Query: 473 ITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVV 532
+ L +V+ D H +LV EL+ GGEL ++I ++K FSE EAS+++ + V ++H GVV
Sbjct: 482 VKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVV 541
Query: 533 HRDLKP 538
HRDLKP
Sbjct: 542 HRDLKP 547
Score = 108 bits (271), Expect = 1e-23
Identities = 76/264 (28%), Positives = 140/264 (53%), Gaps = 23/264 (8%)
Query: 416 DGYVVKETIGVGSYSEC---KRCVHKATNMEYAVKVIDKS----KRDPSE----EIEILL 464
+ + + + +G G+Y + ++ T YA+KV+ K+ K +E E ++L
Sbjct: 47 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 106
Query: 465 RYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVE 524
Q P ++TL + ++L+ + + GGEL + +++ F+E E + I +E
Sbjct: 107 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALE 166
Query: 525 YLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRA-ENGLLMTPCYTANFVAP 583
+LH G+++RD+K NIL +D +G+ + + DFG +K+ A E + C T ++AP
Sbjct: 167 HLHKLGIIYRDIKLENIL-LDSNGH---VVLTDFGLSKEFVADETERAYSFCGTIEYMAP 222
Query: 584 EVLK--RQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGSGKFTLSGGN 640
++++ G+D+ D WSLG+L+Y +L G +PF +G ++ EI RI +
Sbjct: 223 DIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYP--- 279
Query: 641 WNTVSETAKDLVSKMLHVDPHQRL 664
+S AKDL+ ++L DP +RL
Sbjct: 280 -QEMSALAKDLIQRLLMKDPKKRL 302
Score = 83.2 bits (204), Expect = 8e-16
Identities = 47/154 (30%), Positives = 83/154 (53%), Gaps = 18/154 (11%)
Query: 46 ITHHVKAGSEKADP--SHFELL---KVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKAT 100
+T+ ++ K P H++L K LG+GSF + RK S +A+K++ K
Sbjct: 405 VTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFS---ICRKCVHKKSNQAFAVKIISK-- 459
Query: 101 LKVRDRVRTKMERDILA---DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEV 157
R+ +++I A HP +VKLH F + +L+++ L GG+LF R+ K+
Sbjct: 460 -----RMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKK 514
Query: 158 MFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPE 191
F+E + + + +L + H+H +G+++RDLKPE
Sbjct: 515 HFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPE 548
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 377 bits (969), Expect = e-104
Identities = 191/378 (50%), Positives = 260/378 (68%), Gaps = 21/378 (5%)
Query: 43 EISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATL- 101
EIS T V G EK P FELL+VLG+G +GKVF VRKVT ++G ++AMKVLKKA +
Sbjct: 73 EISETS-VNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIV 131
Query: 102 -KVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFT 160
+D TK ER+IL +V HPF+V L YAFQT GKLYLIL++L GG+LF +L +E +F
Sbjct: 132 RNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFM 191
Query: 161 EEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAY 220
E+ FYLAE+++ L HLH GIIYRDLKPENI+L+ +GH+KLTDFGL KE+I +
Sbjct: 192 EDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTH 251
Query: 221 SFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLG 280
+FCGT+EYMAPE++ R GH+ + DWWS G LM++MLTG+ PF G++RK+T+ ILK KL
Sbjct: 252 TFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLN 311
Query: 281 MPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKP 340
+P +L+ EA+ LL+ L KRN A+RLG+GP A E++ H F+ I+W +L R+++PPFKP
Sbjct: 312 LPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP 371
Query: 341 AVAQPDDTFYFDTEFTSRTPKDSPGIPP-SAGAHQLFRGFSFVATGLMED---------- 389
+ +D FD++FT +TP DSP S A+Q+F GF++VA ++E
Sbjct: 372 LLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPK 431
Query: 390 -------DGKPRAPQAPL 400
G PR P +P+
Sbjct: 432 IRSPRRFIGSPRTPVSPV 449
Score = 115 bits (288), Expect = 1e-25
Identities = 78/262 (29%), Positives = 133/262 (50%), Gaps = 23/262 (8%)
Query: 425 GVGSYSECKRCVHKATNMEYAVKVIDKSK--RDPSEEIEI-----LLRYGQHPNIITLKD 477
G G + ++ T +A+KV+ K+ R+ + +L +HP I+ L
Sbjct: 101 GYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIY 160
Query: 478 VYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLK 537
+ G +YL+ E + GGEL ++ R+ F E A F L I + +LH +G+++RDLK
Sbjct: 161 AFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLK 220
Query: 538 PSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDI 597
P NI+ ++ G+ +++ DFG K+ + + T C T ++APE+L R G++ D
Sbjct: 221 PENIM-LNHQGH---VKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDW 276
Query: 598 WSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLH 657
WSLG L+Y ML G PF + ++ + +I K L +++ A+DL+ K+L
Sbjct: 277 WSLGALMYDMLTGAPPFT---GENRKKTIDKILKCKLNLP----PYLTQEARDLLKKLLK 329
Query: 658 VDPHQRL-----TAKQVLQHPW 674
+ RL A +V HP+
Sbjct: 330 RNAASRLGAGPGDAGEVQAHPF 351
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 370 bits (949), Expect = e-102
Identities = 188/392 (47%), Positives = 257/392 (65%), Gaps = 24/392 (6%)
Query: 30 AGLQPSKDEGVLKEISITH-HVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSG 88
AGL+P G +E+ +T V G E+ P FELL+VLG+G +GKVF VRKV + G
Sbjct: 37 AGLEPV---GHYEEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLG 93
Query: 89 HLYAMKVLKKATL--KVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRG 146
+YAMKVL+KA + +D T+ ER+IL V HPF+V+L YAFQT GKLYLIL+ L G
Sbjct: 94 KIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSG 153
Query: 147 GDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDF 206
G+LFT L +E +F E+ FYLAE+ L L HLHS GIIYRDLKPENI+L +GHIKLTDF
Sbjct: 154 GELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDF 213
Query: 207 GLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKD 266
GL KE+I ++FCGT+EYMAPE++ R GH+ + DWWS G LM++MLTGS PF ++
Sbjct: 214 GLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAEN 273
Query: 267 RKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDW 326
RK+TM I++ KL +P +L+ +A+ L++ KRNP+ R+G GP A +++RH F+ ++W
Sbjct: 274 RKKTMDKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNW 333
Query: 327 NKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSP-GIPPSAGAHQLFRGFSFVATG 385
+ L + PPF+P + +D FDT FT +TP DSP S A+Q F GF++VA
Sbjct: 334 DDLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPS 393
Query: 386 LMED-----------------DGKPRAPQAPL 400
+++ + PRAP +PL
Sbjct: 394 VLDSIKEGFSFQPKLRSPRRLNSSPRAPVSPL 425
Score = 127 bits (319), Expect = 4e-29
Identities = 82/243 (33%), Positives = 127/243 (52%), Gaps = 23/243 (9%)
Query: 444 YAVKVIDKSK--RDPSEEIEI-----LLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGE 496
YA+KV+ K+K R+ + +L +HP I+ L + G +YL+ E + GGE
Sbjct: 96 YAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGE 155
Query: 497 LLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRIC 556
L + R+ F E A F L I + +LHSQG+++RDLKP NI+ + +++
Sbjct: 156 LFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGH----IKLT 211
Query: 557 DFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFAN 616
DFG K+ E + T C T ++APE+L R G++ D WSLG L+Y ML G PF
Sbjct: 212 DFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFT- 270
Query: 617 GPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRL-----TAKQVLQ 671
++ ++ + +I GK L ++ A+DLV K L +P QR+ A V +
Sbjct: 271 --AENRKKTMDKIIRGKLALP----PYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQR 324
Query: 672 HPW 674
HP+
Sbjct: 325 HPF 327
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 295 bits (756), Expect = 8e-80
Identities = 146/323 (45%), Positives = 212/323 (65%), Gaps = 9/323 (2%)
Query: 43 EISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLK 102
+ S THH ++ + F+ LK+LG+G+FGKV LVR+ SG YAMK+LKK +
Sbjct: 134 DASTTHH-----KRKTMNDFDYLKLLGKGTFGKVILVREKA---SGKYYAMKILKKEVII 185
Query: 103 VRDRV-RTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTE 161
+D V T E +L + HPF+ L Y+FQT+ +L +++++ GG+LF LS+E +F+E
Sbjct: 186 AKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSE 245
Query: 162 EDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYS 221
+ +FY AE+ LD+LHS I+YRDLK EN++LD++GHIK+TDFGL KE I +
Sbjct: 246 DRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKT 305
Query: 222 FCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGM 281
FCGT EY+APEV+ + + DWW GV+M+EM+ G LPF +D ++ LIL +
Sbjct: 306 FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKF 365
Query: 282 PQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPA 341
P+ LS++A+SLL L ++P RLG GPD A+EI RH F+S ++W +Y +++ PPFKP
Sbjct: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQ 425
Query: 342 VAQPDDTFYFDTEFTSRTPKDSP 364
V DT YFD EFT++T +P
Sbjct: 426 VTSETDTRYFDEEFTAQTITITP 448
Score = 119 bits (297), Expect = 1e-26
Identities = 83/276 (30%), Positives = 140/276 (50%), Gaps = 23/276 (8%)
Query: 408 HGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEI------E 461
H K +D +K +G G++ + KA+ YA+K++ K +E+
Sbjct: 139 HHKRKTMNDFDYLK-LLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTES 197
Query: 462 ILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGK 521
+L+ +HP + +LK + + V E + GGEL + R++ FSE F I
Sbjct: 198 RVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVS 257
Query: 522 TVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFV 581
++YLHS +V+RDLK N++ +D+ G+ ++I DFG K+ + + T C T ++
Sbjct: 258 ALDYLHSGKIVYRDLKLENLM-LDKDGH---IKITDFGLCKEGITDAATMKTFCGTPEYL 313
Query: 582 APEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNW 641
APEVL+ Y D W LG+++Y M+ G PF N + E++ + KF
Sbjct: 314 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEDIKFP------ 366
Query: 642 NTVSETAKDLVSKMLHVDPHQRL-----TAKQVLQH 672
T+S AK L+S +L DP++RL AK++++H
Sbjct: 367 RTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRH 402
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 295 bits (756), Expect = 8e-80
Identities = 146/323 (45%), Positives = 212/323 (65%), Gaps = 9/323 (2%)
Query: 43 EISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLK 102
+ S THH ++ + F+ LK+LG+G+FGKV LVR+ SG YAMK+LKK +
Sbjct: 134 DASTTHH-----KRKTMNDFDYLKLLGKGTFGKVILVREKA---SGKYYAMKILKKEVII 185
Query: 103 VRDRV-RTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTE 161
+D V T E +L + HPF+ L Y+FQT+ +L +++++ GG+LF LS+E +F+E
Sbjct: 186 AKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSE 245
Query: 162 EDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYS 221
+ +FY AE+ LD+LHS I+YRDLK EN++LD++GHIK+TDFGL KE I +
Sbjct: 246 DRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKT 305
Query: 222 FCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGM 281
FCGT EY+APEV+ + + DWW GV+M+EM+ G LPF +D ++ LIL +
Sbjct: 306 FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKF 365
Query: 282 PQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPA 341
P+ LS++A+SLL L ++P RLG GPD A+EI RH F+S ++W +Y +++ PPFKP
Sbjct: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQ 425
Query: 342 VAQPDDTFYFDTEFTSRTPKDSP 364
V DT YFD EFT++T +P
Sbjct: 426 VTSETDTRYFDEEFTAQTITITP 448
Score = 119 bits (297), Expect = 1e-26
Identities = 83/276 (30%), Positives = 140/276 (50%), Gaps = 23/276 (8%)
Query: 408 HGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEI------E 461
H K +D +K +G G++ + KA+ YA+K++ K +E+
Sbjct: 139 HHKRKTMNDFDYLK-LLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTES 197
Query: 462 ILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGK 521
+L+ +HP + +LK + + V E + GGEL + R++ FSE F I
Sbjct: 198 RVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVS 257
Query: 522 TVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFV 581
++YLHS +V+RDLK N++ +D+ G+ ++I DFG K+ + + T C T ++
Sbjct: 258 ALDYLHSGKIVYRDLKLENLM-LDKDGH---IKITDFGLCKEGITDAATMKTFCGTPEYL 313
Query: 582 APEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNW 641
APEVL+ Y D W LG+++Y M+ G PF N + E++ + KF
Sbjct: 314 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEDIKFP------ 366
Query: 642 NTVSETAKDLVSKMLHVDPHQRL-----TAKQVLQH 672
T+S AK L+S +L DP++RL AK++++H
Sbjct: 367 RTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRH 402
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 287 bits (735), Expect = 2e-77
Identities = 143/331 (43%), Positives = 208/331 (62%), Gaps = 10/331 (3%)
Query: 37 DEGVLKEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL 96
D +E+ + V K + F+ LK+LG+G+FGKV LVR+ +G YAMK+L
Sbjct: 129 DSSTTEEMEVA--VSKARAKVTMNDFDYLKLLGKGTFGKVILVREKA---TGRYYAMKIL 183
Query: 97 KKATLKVRDRV-RTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK 155
+K + +D V T E +L + HPF+ L YAFQT +L ++++ GG+LF LS+
Sbjct: 184 RKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSR 243
Query: 156 EVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDH 215
E +FTEE +FY AE+ L++LHS ++YRD+K EN++LD++GHIK+TDFGL KE I
Sbjct: 244 ERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISD 303
Query: 216 EKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLIL 275
+FCGT EY+APEV+ + + DWW GV+M+EM+ G LPF +D + LIL
Sbjct: 304 GATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELIL 363
Query: 276 KAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIK 335
++ P+ LS EA+SLL L K++P RLG GP A+E+ H F+ +I+W + ++++
Sbjct: 364 MEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLL 423
Query: 336 PPFKPAVAQPDDTFYFDTEFTSR----TPKD 362
PPFKP V DT YFD EFT++ TP D
Sbjct: 424 PPFKPQVTSEVDTRYFDDEFTAQSITITPPD 454
Score = 123 bits (309), Expect = 5e-28
Identities = 86/278 (30%), Positives = 140/278 (50%), Gaps = 30/278 (10%)
Query: 424 IGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEI------EILLRYGQHPNIITLKD 477
+G G++ + KAT YA+K++ K +E+ +L+ +HP + LK
Sbjct: 158 LGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKY 217
Query: 478 VYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLK 537
+ + V E GGEL + R++ F+E A F I +EYLHS+ VV+RD+K
Sbjct: 218 AFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIK 277
Query: 538 PSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDI 597
N++ +D+ G+ ++I DFG K+ ++ + T C T ++APEVL+ Y D
Sbjct: 278 LENLM-LDKDGH---IKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDW 333
Query: 598 WSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLH 657
W LG+++Y M+ G PF N + E++ + +F T+S AK L++ +L
Sbjct: 334 WGLGVVMYEMMCGRLPFYNQDHERLFELIL-MEEIRFP------RTLSPEAKSLLAGLLK 386
Query: 658 VDPHQRL-----TAKQVLQHPW--------VTQKDKLP 682
DP QRL AK+V++H + V QK LP
Sbjct: 387 KDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLP 424
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 281 bits (720), Expect = 1e-75
Identities = 144/334 (43%), Positives = 210/334 (62%), Gaps = 11/334 (3%)
Query: 60 SHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRV-RTKMERDILAD 118
+ FE LK+LG+G+FGKV LV++ +G YAMK+LKK + +D V T E +L +
Sbjct: 148 NEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204
Query: 119 VNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHL 178
HPF+ L Y+FQT +L ++++ GG+LF LS+E +F+E+ +FY AE+ LD+L
Sbjct: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264
Query: 179 HS-LGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQ 237
HS ++YRDLK EN++LD++GHIK+TDFGL KE I +FCGT EY+APEV+
Sbjct: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324
Query: 238 GHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALF 297
+ + DWW GV+M+EM+ G LPF +D ++ LIL ++ P+ L EA+SLL L
Sbjct: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLL 384
Query: 298 KRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTS 357
K++P RLG G + A+EI +H F++ I W +Y +++ PPFKP V DT YFD EFT+
Sbjct: 385 KKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTA 444
Query: 358 R----TPKDSPGIPPSAGAHQL--FRGFSFVATG 385
+ TP D + + F FS+ A+G
Sbjct: 445 QMITITPPDQDDSMECVDSERRPHFPQFSYSASG 478
Score = 120 bits (300), Expect = 6e-27
Identities = 84/275 (30%), Positives = 138/275 (50%), Gaps = 23/275 (8%)
Query: 410 KNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEI------EIL 463
K+ V + + + +G G++ + KAT YA+K++ K +E+ +
Sbjct: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201
Query: 464 LRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTV 523
L+ +HP + LK + + V E GGEL + R++ FSE A F I +
Sbjct: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261
Query: 524 EYLHSQ-GVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVA 582
+YLHS+ VV+RDLK N++ +D+ G+ ++I DFG K+ + + T C T ++A
Sbjct: 262 DYLHSEKNVVYRDLKLENLM-LDKDGH---IKITDFGLCKEGIKDGATMKTFCGTPEYLA 317
Query: 583 PEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWN 642
PEVL+ Y D W LG+++Y M+ G PF N + E++ + +F
Sbjct: 318 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEEIRFP------R 370
Query: 643 TVSETAKDLVSKMLHVDPHQRL-----TAKQVLQH 672
T+ AK L+S +L DP QRL AK+++QH
Sbjct: 371 TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH 405
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 281 bits (720), Expect = 1e-75
Identities = 144/334 (43%), Positives = 210/334 (62%), Gaps = 11/334 (3%)
Query: 60 SHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRV-RTKMERDILAD 118
+ FE LK+LG+G+FGKV LV++ +G YAMK+LKK + +D V T E +L +
Sbjct: 148 NEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204
Query: 119 VNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHL 178
HPF+ L Y+FQT +L ++++ GG+LF LS+E +F+E+ +FY AE+ LD+L
Sbjct: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264
Query: 179 HS-LGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQ 237
HS ++YRDLK EN++LD++GHIK+TDFGL KE I +FCGT EY+APEV+
Sbjct: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324
Query: 238 GHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALF 297
+ + DWW GV+M+EM+ G LPF +D ++ LIL ++ P+ L EA+SLL L
Sbjct: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLL 384
Query: 298 KRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTS 357
K++P RLG G + A+EI +H F++ I W +Y +++ PPFKP V DT YFD EFT+
Sbjct: 385 KKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTA 444
Query: 358 R----TPKDSPGIPPSAGAHQL--FRGFSFVATG 385
+ TP D + + F FS+ A+G
Sbjct: 445 QMITITPPDQDDSMECVDSERRPHFPQFSYSASG 478
Score = 120 bits (300), Expect = 6e-27
Identities = 84/275 (30%), Positives = 138/275 (50%), Gaps = 23/275 (8%)
Query: 410 KNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEI------EIL 463
K+ V + + + +G G++ + KAT YA+K++ K +E+ +
Sbjct: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201
Query: 464 LRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTV 523
L+ +HP + LK + + V E GGEL + R++ FSE A F I +
Sbjct: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261
Query: 524 EYLHSQ-GVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVA 582
+YLHS+ VV+RDLK N++ +D+ G+ ++I DFG K+ + + T C T ++A
Sbjct: 262 DYLHSEKNVVYRDLKLENLM-LDKDGH---IKITDFGLCKEGIKDGATMKTFCGTPEYLA 317
Query: 583 PEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWN 642
PEVL+ Y D W LG+++Y M+ G PF N + E++ + +F
Sbjct: 318 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEEIRFP------R 370
Query: 643 TVSETAKDLVSKMLHVDPHQRL-----TAKQVLQH 672
T+ AK L+S +L DP QRL AK+++QH
Sbjct: 371 TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH 405
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 281 bits (720), Expect = 1e-75
Identities = 144/334 (43%), Positives = 210/334 (62%), Gaps = 11/334 (3%)
Query: 60 SHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRV-RTKMERDILAD 118
+ FE LK+LG+G+FGKV LV++ +G YAMK+LKK + +D V T E +L +
Sbjct: 148 NEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204
Query: 119 VNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHL 178
HPF+ L Y+FQT +L ++++ GG+LF LS+E +F+E+ +FY AE+ LD+L
Sbjct: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264
Query: 179 HS-LGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQ 237
HS ++YRDLK EN++LD++GHIK+TDFGL KE I +FCGT EY+APEV+
Sbjct: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324
Query: 238 GHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALF 297
+ + DWW GV+M+EM+ G LPF +D ++ LIL ++ P+ L EA+SLL L
Sbjct: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLL 384
Query: 298 KRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTS 357
K++P RLG G + A+EI +H F++ I W +Y +++ PPFKP V DT YFD EFT+
Sbjct: 385 KKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTA 444
Query: 358 R----TPKDSPGIPPSAGAHQL--FRGFSFVATG 385
+ TP D + + F FS+ A+G
Sbjct: 445 QMITITPPDQDDSMECVDSERRPHFPQFSYSASG 478
Score = 120 bits (300), Expect = 6e-27
Identities = 84/275 (30%), Positives = 138/275 (50%), Gaps = 23/275 (8%)
Query: 410 KNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEI------EIL 463
K+ V + + + +G G++ + KAT YA+K++ K +E+ +
Sbjct: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201
Query: 464 LRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTV 523
L+ +HP + LK + + V E GGEL + R++ FSE A F I +
Sbjct: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261
Query: 524 EYLHSQ-GVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVA 582
+YLHS+ VV+RDLK N++ +D+ G+ ++I DFG K+ + + T C T ++A
Sbjct: 262 DYLHSEKNVVYRDLKLENLM-LDKDGH---IKITDFGLCKEGIKDGATMKTFCGTPEYLA 317
Query: 583 PEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWN 642
PEVL+ Y D W LG+++Y M+ G PF N + E++ + +F
Sbjct: 318 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEEIRFP------R 370
Query: 643 TVSETAKDLVSKMLHVDPHQRL-----TAKQVLQH 672
T+ AK L+S +L DP QRL AK+++QH
Sbjct: 371 TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH 405
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 281 bits (720), Expect = 1e-75
Identities = 161/391 (41%), Positives = 225/391 (57%), Gaps = 35/391 (8%)
Query: 1 MPLAQLKEPWPLMELVPLDPENGQTSGEEAGLQPSKDEGVLKEISITHHVKAGSEKADPS 60
+ ++Q +EP EL+ +P + ++ L PS + A PS
Sbjct: 58 LKISQPQEP----ELMNANPSPPPSPSQQINLGPSSNP-----------------HAKPS 96
Query: 61 HFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL-KKATLKVRDRVRTKMERDILA-D 118
F LKV+G+GSFGKV L R YA+KVL KKA LK ++ ER++L +
Sbjct: 97 DFHFLKVIGKGSFGKVLLARHKAEEV---FYAVKVLQKKAILKKKEEKHIMSERNVLLKN 153
Query: 119 VNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHL 178
V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A L +L
Sbjct: 154 VKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYL 213
Query: 179 HSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQG 238
HSL I+YRDLKPENILLD +GHI LTDFGL KE I+H +FCGT EY+APEV+++Q
Sbjct: 214 HSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQP 273
Query: 239 HSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFK 298
+ + DWW G +++EML G PF ++ E IL L + ++ A+ LL L +
Sbjct: 274 YDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQ 333
Query: 299 RNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSR 358
++ RLG+ D EIK HVF+S I+W+ L ++I PPF P V+ P+D +FD EFT
Sbjct: 334 KDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE 392
Query: 359 TPKDSPGIPPSA--------GAHQLFRGFSF 381
+S G P + A + F GFS+
Sbjct: 393 PVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 423
Score = 125 bits (314), Expect = 1e-28
Identities = 87/261 (33%), Positives = 131/261 (50%), Gaps = 21/261 (8%)
Query: 415 SDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKS-------KRDPSEEIEILLRYG 467
SD + +K IG GS+ + HKA + YAVKV+ K ++ E +LL+
Sbjct: 96 SDFHFLK-VIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNV 154
Query: 468 QHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLH 527
+HP ++ L + +Y V + + GGEL + R++ F E A F I + YLH
Sbjct: 155 KHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLH 214
Query: 528 SQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK 587
S +V+RDLKP NIL +D G+ + + DFG K+ N T C T ++APEVL
Sbjct: 215 SLNIVYRDLKPENIL-LDSQGH---IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLH 270
Query: 588 RQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGSGKFTLSGGNWNTVSE 646
+Q YD D W LG +LY ML G PF + ++ + IL + K ++
Sbjct: 271 KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK--------PNITN 322
Query: 647 TAKDLVSKMLHVDPHQRLTAK 667
+A+ L+ +L D +RL AK
Sbjct: 323 SARHLLEGLLQKDRTKRLGAK 343
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 281 bits (720), Expect = 1e-75
Identities = 161/391 (41%), Positives = 225/391 (57%), Gaps = 35/391 (8%)
Query: 1 MPLAQLKEPWPLMELVPLDPENGQTSGEEAGLQPSKDEGVLKEISITHHVKAGSEKADPS 60
+ ++Q +EP EL+ +P + ++ L PS + A PS
Sbjct: 72 LKISQPQEP----ELMNANPSPPPSPSQQINLGPSSNP-----------------HAKPS 110
Query: 61 HFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL-KKATLKVRDRVRTKMERDILA-D 118
F LKV+G+GSFGKV L R YA+KVL KKA LK ++ ER++L +
Sbjct: 111 DFHFLKVIGKGSFGKVLLARHKAEEV---FYAVKVLQKKAILKKKEEKHIMSERNVLLKN 167
Query: 119 VNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHL 178
V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A L +L
Sbjct: 168 VKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYL 227
Query: 179 HSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQG 238
HSL I+YRDLKPENILLD +GHI LTDFGL KE I+H +FCGT EY+APEV+++Q
Sbjct: 228 HSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQP 287
Query: 239 HSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFK 298
+ + DWW G +++EML G PF ++ E IL L + ++ A+ LL L +
Sbjct: 288 YDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQ 347
Query: 299 RNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSR 358
++ RLG+ D EIK HVF+S I+W+ L ++I PPF P V+ P+D +FD EFT
Sbjct: 348 KDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE 406
Query: 359 TPKDSPGIPPSA--------GAHQLFRGFSF 381
+S G P + A + F GFS+
Sbjct: 407 PVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 437
Score = 125 bits (314), Expect = 1e-28
Identities = 87/261 (33%), Positives = 131/261 (50%), Gaps = 21/261 (8%)
Query: 415 SDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKS-------KRDPSEEIEILLRYG 467
SD + +K IG GS+ + HKA + YAVKV+ K ++ E +LL+
Sbjct: 110 SDFHFLK-VIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNV 168
Query: 468 QHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLH 527
+HP ++ L + +Y V + + GGEL + R++ F E A F I + YLH
Sbjct: 169 KHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLH 228
Query: 528 SQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK 587
S +V+RDLKP NIL +D G+ + + DFG K+ N T C T ++APEVL
Sbjct: 229 SLNIVYRDLKPENIL-LDSQGH---IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLH 284
Query: 588 RQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGSGKFTLSGGNWNTVSE 646
+Q YD D W LG +LY ML G PF + ++ + IL + K ++
Sbjct: 285 KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK--------PNITN 336
Query: 647 TAKDLVSKMLHVDPHQRLTAK 667
+A+ L+ +L D +RL AK
Sbjct: 337 SARHLLEGLLQKDRTKRLGAK 357
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 281 bits (720), Expect = 1e-75
Identities = 161/391 (41%), Positives = 225/391 (57%), Gaps = 35/391 (8%)
Query: 1 MPLAQLKEPWPLMELVPLDPENGQTSGEEAGLQPSKDEGVLKEISITHHVKAGSEKADPS 60
+ ++Q +EP EL+ +P + ++ L PS + A PS
Sbjct: 86 LKISQPQEP----ELMNANPSPPPSPSQQINLGPSSNP-----------------HAKPS 124
Query: 61 HFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL-KKATLKVRDRVRTKMERDILA-D 118
F LKV+G+GSFGKV L R YA+KVL KKA LK ++ ER++L +
Sbjct: 125 DFHFLKVIGKGSFGKVLLARHKAEEV---FYAVKVLQKKAILKKKEEKHIMSERNVLLKN 181
Query: 119 VNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHL 178
V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A L +L
Sbjct: 182 VKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYL 241
Query: 179 HSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQG 238
HSL I+YRDLKPENILLD +GHI LTDFGL KE I+H +FCGT EY+APEV+++Q
Sbjct: 242 HSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQP 301
Query: 239 HSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFK 298
+ + DWW G +++EML G PF ++ E IL L + ++ A+ LL L +
Sbjct: 302 YDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQ 361
Query: 299 RNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSR 358
++ RLG+ D EIK HVF+S I+W+ L ++I PPF P V+ P+D +FD EFT
Sbjct: 362 KDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE 420
Query: 359 TPKDSPGIPPSA--------GAHQLFRGFSF 381
+S G P + A + F GFS+
Sbjct: 421 PVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 451
Score = 125 bits (314), Expect = 1e-28
Identities = 87/261 (33%), Positives = 131/261 (50%), Gaps = 21/261 (8%)
Query: 415 SDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKS-------KRDPSEEIEILLRYG 467
SD + +K IG GS+ + HKA + YAVKV+ K ++ E +LL+
Sbjct: 124 SDFHFLK-VIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNV 182
Query: 468 QHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLH 527
+HP ++ L + +Y V + + GGEL + R++ F E A F I + YLH
Sbjct: 183 KHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLH 242
Query: 528 SQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK 587
S +V+RDLKP NIL +D G+ + + DFG K+ N T C T ++APEVL
Sbjct: 243 SLNIVYRDLKPENIL-LDSQGH---IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLH 298
Query: 588 RQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGSGKFTLSGGNWNTVSE 646
+Q YD D W LG +LY ML G PF + ++ + IL + K ++
Sbjct: 299 KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK--------PNITN 350
Query: 647 TAKDLVSKMLHVDPHQRLTAK 667
+A+ L+ +L D +RL AK
Sbjct: 351 SARHLLEGLLQKDRTKRLGAK 371
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 281 bits (720), Expect = 1e-75
Identities = 161/391 (41%), Positives = 225/391 (57%), Gaps = 35/391 (8%)
Query: 1 MPLAQLKEPWPLMELVPLDPENGQTSGEEAGLQPSKDEGVLKEISITHHVKAGSEKADPS 60
+ ++Q +EP EL+ +P + ++ L PS + A PS
Sbjct: 153 LKISQPQEP----ELMNANPSPPPSPSQQINLGPSSNP-----------------HAKPS 191
Query: 61 HFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL-KKATLKVRDRVRTKMERDILA-D 118
F LKV+G+GSFGKV L R YA+KVL KKA LK ++ ER++L +
Sbjct: 192 DFHFLKVIGKGSFGKVLLARHKAEEV---FYAVKVLQKKAILKKKEEKHIMSERNVLLKN 248
Query: 119 VNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHL 178
V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A L +L
Sbjct: 249 VKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYL 308
Query: 179 HSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQG 238
HSL I+YRDLKPENILLD +GHI LTDFGL KE I+H +FCGT EY+APEV+++Q
Sbjct: 309 HSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQP 368
Query: 239 HSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFK 298
+ + DWW G +++EML G PF ++ E IL L + ++ A+ LL L +
Sbjct: 369 YDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQ 428
Query: 299 RNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSR 358
++ RLG+ D EIK HVF+S I+W+ L ++I PPF P V+ P+D +FD EFT
Sbjct: 429 KDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE 487
Query: 359 TPKDSPGIPPSA--------GAHQLFRGFSF 381
+S G P + A + F GFS+
Sbjct: 488 PVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 518
Score = 125 bits (314), Expect = 1e-28
Identities = 87/261 (33%), Positives = 131/261 (50%), Gaps = 21/261 (8%)
Query: 415 SDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKS-------KRDPSEEIEILLRYG 467
SD + +K IG GS+ + HKA + YAVKV+ K ++ E +LL+
Sbjct: 191 SDFHFLK-VIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNV 249
Query: 468 QHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLH 527
+HP ++ L + +Y V + + GGEL + R++ F E A F I + YLH
Sbjct: 250 KHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLH 309
Query: 528 SQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK 587
S +V+RDLKP NIL +D G+ + + DFG K+ N T C T ++APEVL
Sbjct: 310 SLNIVYRDLKPENIL-LDSQGH---IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLH 365
Query: 588 RQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGSGKFTLSGGNWNTVSE 646
+Q YD D W LG +LY ML G PF + ++ + IL + K ++
Sbjct: 366 KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK--------PNITN 417
Query: 647 TAKDLVSKMLHVDPHQRLTAK 667
+A+ L+ +L D +RL AK
Sbjct: 418 SARHLLEGLLQKDRTKRLGAK 438
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 281 bits (719), Expect = 2e-75
Identities = 153/346 (44%), Positives = 210/346 (60%), Gaps = 15/346 (4%)
Query: 52 AGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL-KKATLKVRDRVRTK 110
+ + A P+ F+ LKV+G+G++GKV L + R G YA+KVL KK+ LK +++
Sbjct: 25 SANPNAQPTDFDFLKVIGKGNYGKVLLAK---RKSDGAFYAVKVLQKKSILKKKEQSHIM 81
Query: 111 MERDILA-DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 169
ER +L +V HPF+V L Y+FQT KLY +LD++ GG+LF L +E F E +FY A
Sbjct: 82 AERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAA 141
Query: 170 ELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYM 229
E+A + +LHSL IIYRDLKPENILLD +GH+ LTDFGL KE ++ E +FCGT EY+
Sbjct: 142 EVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYL 201
Query: 230 APEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEA 289
APEV+ ++ + + DWW G +++EML G PF +D + IL L +P + A
Sbjct: 202 APEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAA 261
Query: 290 QSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTF 349
LL++L ++ RLGS D EIK HVF+S I+W+ LY + + PPF P V P D
Sbjct: 262 CDLLQSLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLK 320
Query: 350 YFDTEFTSRTPKDSPGIPP-----SAGAHQLFRGFSFVATGLMEDD 390
+FD EFT S G P S+GA F GFS+ EDD
Sbjct: 321 HFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAP----EDD 362
Score = 124 bits (312), Expect = 2e-28
Identities = 83/253 (32%), Positives = 127/253 (50%), Gaps = 18/253 (7%)
Query: 422 ETIGVGSYSECKRCVHKATNMEYAVKVIDKS----KRDPSE---EIEILLRYGQHPNIIT 474
+ IG G+Y + K+ YAVKV+ K K++ S E +LL+ +HP ++
Sbjct: 39 KVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVG 98
Query: 475 LKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 534
L+ + + +Y V + + GGEL + R++ F E A F + + YLHS +++R
Sbjct: 99 LRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYR 158
Query: 535 DLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEG 594
DLKP NIL +D G+ + + DFG K+ T C T ++APEVL+++ YD
Sbjct: 159 DLKPENIL-LDCQGH---VVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRA 214
Query: 595 CDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSK 654
D W LG +LY ML G PF S ++ I + GG + A DL+
Sbjct: 215 VDWWCLGAVLYEMLHGLPPFY---SQDVSQMYENILHQPLQIPGGR----TVAACDLLQS 267
Query: 655 MLHVDPHQRLTAK 667
+LH D QRL +K
Sbjct: 268 LLHKDQRQRLGSK 280
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 281 bits (719), Expect = 2e-75
Identities = 153/346 (44%), Positives = 210/346 (60%), Gaps = 15/346 (4%)
Query: 52 AGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL-KKATLKVRDRVRTK 110
+ + A P+ F+ LKV+G+G++GKV L + R G YA+KVL KK+ LK +++
Sbjct: 85 SANPNAQPTDFDFLKVIGKGNYGKVLLAK---RKSDGAFYAVKVLQKKSILKKKEQSHIM 141
Query: 111 MERDILA-DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 169
ER +L +V HPF+V L Y+FQT KLY +LD++ GG+LF L +E F E +FY A
Sbjct: 142 AERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAA 201
Query: 170 ELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYM 229
E+A + +LHSL IIYRDLKPENILLD +GH+ LTDFGL KE ++ E +FCGT EY+
Sbjct: 202 EVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYL 261
Query: 230 APEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEA 289
APEV+ ++ + + DWW G +++EML G PF +D + IL L +P + A
Sbjct: 262 APEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAA 321
Query: 290 QSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTF 349
LL++L ++ RLGS D EIK HVF+S I+W+ LY + + PPF P V P D
Sbjct: 322 CDLLQSLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLK 380
Query: 350 YFDTEFTSRTPKDSPGIPP-----SAGAHQLFRGFSFVATGLMEDD 390
+FD EFT S G P S+GA F GFS+ EDD
Sbjct: 381 HFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAP----EDD 422
Score = 124 bits (312), Expect = 2e-28
Identities = 83/253 (32%), Positives = 127/253 (50%), Gaps = 18/253 (7%)
Query: 422 ETIGVGSYSECKRCVHKATNMEYAVKVIDKS----KRDPSE---EIEILLRYGQHPNIIT 474
+ IG G+Y + K+ YAVKV+ K K++ S E +LL+ +HP ++
Sbjct: 99 KVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVG 158
Query: 475 LKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 534
L+ + + +Y V + + GGEL + R++ F E A F + + YLHS +++R
Sbjct: 159 LRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYR 218
Query: 535 DLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEG 594
DLKP NIL +D G+ + + DFG K+ T C T ++APEVL+++ YD
Sbjct: 219 DLKPENIL-LDCQGH---VVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRA 274
Query: 595 CDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSK 654
D W LG +LY ML G PF S ++ I + GG + A DL+
Sbjct: 275 VDWWCLGAVLYEMLHGLPPFY---SQDVSQMYENILHQPLQIPGGR----TVAACDLLQS 327
Query: 655 MLHVDPHQRLTAK 667
+LH D QRL +K
Sbjct: 328 LLHKDQRQRLGSK 340
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 271 bits (692), Expect = 2e-72
Identities = 144/310 (46%), Positives = 195/310 (62%), Gaps = 6/310 (1%)
Query: 52 AGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL-KKATLKVRDRVRTK 110
+G+ A P+ F+ LKV+G+GSFGKV L + R G YA+KVL KK L +++
Sbjct: 152 SGNPHAKPTDFDFLKVIGKGSFGKVLLAK---RKLDGKFYAVKVLQKKIVLNRKEQKHIM 208
Query: 111 MERDILA-DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 169
ER++L +V HPF+V LHY+FQT KLY +LDF+ GG+LF L +E F E +FY A
Sbjct: 209 AERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAA 268
Query: 170 ELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYM 229
E+A L +LHS+ I+YRDLKPENILLD GH+ LTDFGL KE I +FCGT EY+
Sbjct: 269 EIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYL 328
Query: 230 APEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEA 289
APEV+ +Q + ++ DWW G +++EML G PF +D E IL L + +S A
Sbjct: 329 APEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTA 388
Query: 290 QSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTF 349
S+L L +++ NRLG+ D EI+ H F+ ++ W L +++I PPF P VA PDD
Sbjct: 389 WSILEELLEKDRQNRLGAKEDFL-EIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIR 447
Query: 350 YFDTEFTSRT 359
FDT FT T
Sbjct: 448 NFDTAFTEET 457
Score = 119 bits (298), Expect = 1e-26
Identities = 86/265 (32%), Positives = 132/265 (49%), Gaps = 24/265 (9%)
Query: 422 ETIGVGSYSECKRCVHKATNMEYAVKVIDKS-------KRDPSEEIEILLRYGQHPNIIT 474
+ IG GS+ + K YAVKV+ K ++ E +LL+ +HP ++
Sbjct: 166 KVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVG 225
Query: 475 LKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 534
L + + +Y V + + GGEL + R++ F E A F I + YLHS +V+R
Sbjct: 226 LHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYR 285
Query: 535 DLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEG 594
DLKP NIL +D G+ + + DFG K+ A + T C T ++APEV+++Q YD
Sbjct: 286 DLKPENIL-LDSVGH---VVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNT 341
Query: 595 CDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVS 653
D W LG +LY ML G PF ++ + IL + +L G VS TA ++
Sbjct: 342 VDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHK----PLSLRPG----VSLTAWSILE 393
Query: 654 KMLHVDPHQRLTAK----QVLQHPW 674
++L D RL AK ++ HP+
Sbjct: 394 ELLEKDRQNRLGAKEDFLEIQNHPF 418
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 271 bits (692), Expect = 2e-72
Identities = 144/310 (46%), Positives = 195/310 (62%), Gaps = 6/310 (1%)
Query: 52 AGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL-KKATLKVRDRVRTK 110
+G+ A P+ F+ LKV+G+GSFGKV L + R G YA+KVL KK L +++
Sbjct: 152 SGNPHAKPTDFDFLKVIGKGSFGKVLLAK---RKLDGKFYAVKVLQKKIVLNRKEQKHIM 208
Query: 111 MERDILA-DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 169
ER++L +V HPF+V LHY+FQT KLY +LDF+ GG+LF L +E F E +FY A
Sbjct: 209 AERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAA 268
Query: 170 ELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYM 229
E+A L +LHS+ I+YRDLKPENILLD GH+ LTDFGL KE I +FCGT EY+
Sbjct: 269 EIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYL 328
Query: 230 APEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEA 289
APEV+ +Q + ++ DWW G +++EML G PF +D E IL L + +S A
Sbjct: 329 APEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTA 388
Query: 290 QSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTF 349
S+L L +++ NRLG+ D EI+ H F+ ++ W L +++I PPF P VA PDD
Sbjct: 389 WSILEELLEKDRQNRLGAKEDFL-EIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIR 447
Query: 350 YFDTEFTSRT 359
FDT FT T
Sbjct: 448 NFDTAFTEET 457
Score = 119 bits (298), Expect = 1e-26
Identities = 86/265 (32%), Positives = 132/265 (49%), Gaps = 24/265 (9%)
Query: 422 ETIGVGSYSECKRCVHKATNMEYAVKVIDKS-------KRDPSEEIEILLRYGQHPNIIT 474
+ IG GS+ + K YAVKV+ K ++ E +LL+ +HP ++
Sbjct: 166 KVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVG 225
Query: 475 LKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 534
L + + +Y V + + GGEL + R++ F E A F I + YLHS +V+R
Sbjct: 226 LHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYR 285
Query: 535 DLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEG 594
DLKP NIL +D G+ + + DFG K+ A + T C T ++APEV+++Q YD
Sbjct: 286 DLKPENIL-LDSVGH---VVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNT 341
Query: 595 CDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVS 653
D W LG +LY ML G PF ++ + IL + +L G VS TA ++
Sbjct: 342 VDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHK----PLSLRPG----VSLTAWSILE 393
Query: 654 KMLHVDPHQRLTAK----QVLQHPW 674
++L D RL AK ++ HP+
Sbjct: 394 ELLEKDRQNRLGAKEDFLEIQNHPF 418
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 264 bits (674), Expect = 3e-70
Identities = 136/307 (44%), Positives = 190/307 (61%), Gaps = 9/307 (2%)
Query: 62 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVR-TKMERDILA-DV 119
F L VLG+GSFGKV L R + LYA+K+LKK + D V T +E+ +LA
Sbjct: 342 FNFLMVLGKGSFGKVMLSE---RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398
Query: 120 NHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLH 179
PF+ +LH FQT +LY +++++ GGDL + + F E FY AE+A+GL L
Sbjct: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458
Query: 180 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGH 239
S GIIYRDLK +N++LD EGHIK+ DFG+ KE I +FCGT +Y+APE++ Q +
Sbjct: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518
Query: 240 SHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKR 299
S DWW++GVL++EML G PF+G+D E I++ + P+ +S EA ++ + L +
Sbjct: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTK 578
Query: 300 NPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSR- 358
+P RLG GP+G +IK H F+ IDW KL R+EI+PP+KP DT FD EFT +
Sbjct: 579 HPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQP 638
Query: 359 ---TPKD 362
TP D
Sbjct: 639 VELTPTD 645
Score = 103 bits (258), Expect = 4e-22
Identities = 63/204 (30%), Positives = 103/204 (50%), Gaps = 11/204 (5%)
Query: 424 IGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIE-------ILLRYGQHPNIITLK 476
+G GS+ + K T+ YAVK++ K +++E +L G+ P + L
Sbjct: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407
Query: 477 DVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDL 536
+ +Y V E + GG+L+ I + F E A F I + +L S+G+++RDL
Sbjct: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467
Query: 537 KPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCD 596
K N++ +D G+ ++I DFG K+ + T C T +++APE++ Q Y + D
Sbjct: 468 KLDNVM-LDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVD 523
Query: 597 IWSLGILLYTMLAGYTPFANGPSD 620
W+ G+LLY MLAG PF D
Sbjct: 524 WWAFGVLLYEMLAGQAPFEGEDED 547
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 259 bits (663), Expect = 5e-69
Identities = 150/364 (41%), Positives = 211/364 (57%), Gaps = 19/364 (5%)
Query: 28 EEAGLQPSKDEGVLKEISITHHVKAGSEKADP---SHFELLKVLGQGSFGKVFLVRKVTR 84
E+A L P+ + K IS + K S D + F L VLG+GSFGKV L R
Sbjct: 306 EKAKLGPAGN----KVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLA---DR 358
Query: 85 PDSGHLYAMKVLKKATLKVRDRVR-TKMERDILADVNHP-FVVKLHYAFQTEGKLYLILD 142
+ LYA+K+LKK + D V T +E+ +LA ++ P F+ +LH FQT +LY +++
Sbjct: 359 KGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVME 418
Query: 143 FLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIK 202
++ GGDL + + F E FY AE+++GL LH GIIYRDLK +N++LD EGHIK
Sbjct: 419 YVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIK 478
Query: 203 LTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPF 262
+ DFG+ KE + +FCGT +Y+APE++ Q + S DWW+YGVL++EML G PF
Sbjct: 479 IADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPF 538
Query: 263 QGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYS 322
G+D E I++ + P+ LS EA S+ + L ++PA RLG GP+G +++ H F+
Sbjct: 539 DGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFR 598
Query: 323 TIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQL----FRG 378
IDW KL REI+PPFKP V FD FT P +P P + F G
Sbjct: 599 RIDWEKLENREIQPPFKPKVC-GKGAENFDKFFTRGQPVLTP--PDQLVIANIDQSDFEG 655
Query: 379 FSFV 382
FS+V
Sbjct: 656 FSYV 659
Score = 103 bits (258), Expect = 4e-22
Identities = 61/204 (29%), Positives = 102/204 (50%), Gaps = 11/204 (5%)
Query: 424 IGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIE-------ILLRYGQHPNIITLK 476
+G GS+ + K T YA+K++ K +++E +L + P + L
Sbjct: 345 LGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLH 404
Query: 477 DVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDL 536
+ +Y V E + GG+L+ I + F E +A F I + +LH +G+++RDL
Sbjct: 405 SCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDL 464
Query: 537 KPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCD 596
K N++ +D G+ ++I DFG K+ + T C T +++APE++ Q Y + D
Sbjct: 465 KLDNVM-LDSEGH---IKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVD 520
Query: 597 IWSLGILLYTMLAGYTPFANGPSD 620
W+ G+LLY MLAG PF D
Sbjct: 521 WWAYGVLLYEMLAGQPPFDGEDED 544
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 258 bits (659), Expect = 1e-68
Identities = 141/337 (41%), Positives = 201/337 (59%), Gaps = 12/337 (3%)
Query: 62 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVR-TKMERDILA-DV 119
F L VLG+GSFGKV L R + LYA+K+LKK + D V T +E+ +LA
Sbjct: 342 FNFLMVLGKGSFGKVMLSE---RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398
Query: 120 NHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLH 179
PF+ +LH FQT +LY +++++ GGDL + + F E FY AE+A+GL L
Sbjct: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458
Query: 180 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGH 239
S GIIYRDLK +N++LD EGHIK+ DFG+ KE I +FCGT +Y+APE++ Q +
Sbjct: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518
Query: 240 SHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKR 299
S DWW++GVL++EML G PF+G+D E I++ + P+ +S EA ++ + L +
Sbjct: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTK 578
Query: 300 NPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRT 359
+P RLG GP+G +IK H F+ IDW KL R+EI+PP+KP A + FD FT
Sbjct: 579 HPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPK-ACGRNAENFDRFFTRHP 637
Query: 360 PKDSPGIPPSAGAHQL----FRGFSFVATGLMEDDGK 392
P +P P + F GFSFV + ++ + K
Sbjct: 638 PVLTP--PDQEVIRNIDQSEFEGFSFVNSEFLKPEVK 672
Score = 103 bits (258), Expect = 4e-22
Identities = 63/204 (30%), Positives = 103/204 (50%), Gaps = 11/204 (5%)
Query: 424 IGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIE-------ILLRYGQHPNIITLK 476
+G GS+ + K T+ YAVK++ K +++E +L G+ P + L
Sbjct: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407
Query: 477 DVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDL 536
+ +Y V E + GG+L+ I + F E A F I + +L S+G+++RDL
Sbjct: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467
Query: 537 KPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCD 596
K N++ +D G+ ++I DFG K+ + T C T +++APE++ Q Y + D
Sbjct: 468 KLDNVM-LDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVD 523
Query: 597 IWSLGILLYTMLAGYTPFANGPSD 620
W+ G+LLY MLAG PF D
Sbjct: 524 WWAFGVLLYEMLAGQAPFEGEDED 547
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 258 bits (659), Expect = 1e-68
Identities = 135/329 (41%), Positives = 197/329 (59%), Gaps = 11/329 (3%)
Query: 62 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKM-ERDILADVN 120
F VLG+G FGKV L ++ ++A+K LKK + RD V + M E+ I VN
Sbjct: 657 FRCCAVLGRGHFGKVLLAEY---KNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVN 713
Query: 121 ---HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDH 177
HPF+V L FQT+ + ++++ GGDL + +V F+E FY A + LGL +
Sbjct: 714 SVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDV-FSEPRAVFYAACVVLGLQY 772
Query: 178 LHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQ 237
LH I+YRDLK +N+LLD EG +K+ DFGL KE + + + +FCGT E++APEV+
Sbjct: 773 LHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTET 832
Query: 238 GHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALF 297
++ + DWW GVL++EML G PF G D +E I+ ++ P+FLSTEA S++R L
Sbjct: 833 SYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLL 892
Query: 298 KRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTS 357
+RNP RLG+ AE++K+H F+ IDW+ L +++KPPF P + +D FD EFTS
Sbjct: 893 RRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTS 952
Query: 358 RTPKDSPGIPP---SAGAHQLFRGFSFVA 383
P +P P S ++FR F ++A
Sbjct: 953 EAPILTPPREPRILSEEEQEMFRDFDYIA 981
Score = 110 bits (276), Expect = 4e-24
Identities = 87/307 (28%), Positives = 143/307 (46%), Gaps = 32/307 (10%)
Query: 388 EDDGKPRAPQAPL-HSVVQQLHGKNLVFSDGYVVKE-----TIGVGSYSECKRCVHKATN 441
+ + KP PQ+ L +S +Q+L + + +++ +G G + + +K TN
Sbjct: 621 QSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTN 680
Query: 442 MEYAVKVIDKSKRDPSEEIEILL---------RYGQHPNIITLKDVYDDGKHVYLVTELM 492
+A+K + K +E++ L+ +HP ++ L + +HV V E
Sbjct: 681 EMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYA 740
Query: 493 RGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPEC 552
GG+L+ I FSE A F + ++YLH +V+RDLK N+L +D G
Sbjct: 741 AGGDLMMHI-HTDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLL-LDTEG---F 795
Query: 553 LRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYT 612
++I DFG K+ T C T F+APEVL Y D W LG+L+Y ML G +
Sbjct: 796 VKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGES 855
Query: 613 PFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRL-----TAK 667
PF P D EE+ I + + +S A ++ ++L +P +RL A+
Sbjct: 856 PF---PGDDEEEVFDSIVNDEVRYP----RFLSTEAISIMRRLLRRNPERRLGASEKDAE 908
Query: 668 QVLQHPW 674
V +HP+
Sbjct: 909 DVKKHPF 915
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,202,792
Number of Sequences: 37866
Number of extensions: 1381884
Number of successful extensions: 7643
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 746
Number of HSP's successfully gapped in prelim test: 67
Number of HSP's that attempted gapping in prelim test: 2881
Number of HSP's gapped (non-prelim): 1858
length of query: 735
length of database: 18,247,518
effective HSP length: 110
effective length of query: 625
effective length of database: 14,082,258
effective search space: 8801411250
effective search space used: 8801411250
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.