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Search of human proteins with 190684644
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
sapiens]
(797 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 1613 0.0
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 1523 0.0
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 692 0.0
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 689 0.0
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 689 0.0
gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens] 564 e-160
gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo sapi... 561 e-160
gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo sapi... 520 e-147
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens] 515 e-146
gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens] 515 e-146
gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens] 515 e-146
gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo sapi... 335 1e-91
gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo sapi... 261 2e-69
gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo sapi... 237 4e-62
gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo sapi... 234 3e-61
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 105 1e-22
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom... 105 1e-22
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 103 8e-22
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 98 3e-20
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 98 3e-20
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa... 98 3e-20
gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1 [... 90 7e-18
gi|22749129 RasGEF domain family, member 1B [Homo sapiens] 84 4e-16
gi|40255197 RasGEF domain family, member 1C [Homo sapiens] 83 1e-15
gi|15529996 son of sevenless homolog 1 [Homo sapiens] 82 1e-15
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo... 80 6e-15
gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b ... 79 2e-14
gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [... 79 2e-14
gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a ... 79 2e-14
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa... 77 8e-14
>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
sapiens]
Length = 797
Score = 1613 bits (4178), Expect = 0.0
Identities = 797/797 (100%), Positives = 797/797 (100%)
Query: 1 MGTLGKAREAPRKPSHGCRAASKARLEAKPANSPFPSHPSLAHITQFRMMVSLGHLAKGA 60
MGTLGKAREAPRKPSHGCRAASKARLEAKPANSPFPSHPSLAHITQFRMMVSLGHLAKGA
Sbjct: 1 MGTLGKAREAPRKPSHGCRAASKARLEAKPANSPFPSHPSLAHITQFRMMVSLGHLAKGA 60
Query: 61 SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALAKNSPG 120
SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALAKNSPG
Sbjct: 61 SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALAKNSPG 120
Query: 121 LCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQINARDWS 180
LCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQINARDWS
Sbjct: 121 LCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQINARDWS 180
Query: 181 RKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKE 240
RKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKE
Sbjct: 181 RKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKE 240
Query: 241 NPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGG 300
NPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGG
Sbjct: 241 NPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGG 300
Query: 301 LCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLK 360
LCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLK
Sbjct: 301 LCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLK 360
Query: 361 DLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLY 420
DLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLY
Sbjct: 361 DLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLY 420
Query: 421 YTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFK 480
YTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFK
Sbjct: 421 YTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFK 480
Query: 481 NYDHDQDGYISQEEFEKIAASFPFSFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGF 540
NYDHDQDGYISQEEFEKIAASFPFSFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGF
Sbjct: 481 NYDHDQDGYISQEEFEKIAASFPFSFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGF 540
Query: 541 PHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRAKNPVA 600
PHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRAKNPVA
Sbjct: 541 PHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRAKNPVA 600
Query: 601 PTENNTSVGPVSNLCSLGAKDLLHAPEEGPFTFPNGEAVEHGEESKDRTIMLMGVSSQKI 660
PTENNTSVGPVSNLCSLGAKDLLHAPEEGPFTFPNGEAVEHGEESKDRTIMLMGVSSQKI
Sbjct: 601 PTENNTSVGPVSNLCSLGAKDLLHAPEEGPFTFPNGEAVEHGEESKDRTIMLMGVSSQKI 660
Query: 661 SLRLKRAVAHKATQTESQPWIGSEGPSGPFVLSSPRKTAQDTLYVLPSPTSPCPSPVLVR 720
SLRLKRAVAHKATQTESQPWIGSEGPSGPFVLSSPRKTAQDTLYVLPSPTSPCPSPVLVR
Sbjct: 661 SLRLKRAVAHKATQTESQPWIGSEGPSGPFVLSSPRKTAQDTLYVLPSPTSPCPSPVLVR 720
Query: 721 KRAFVKWENKDSLIKSKEELRHLRLPTYQELEQEINTLKADNDALKIQLKYAQKKIESLQ 780
KRAFVKWENKDSLIKSKEELRHLRLPTYQELEQEINTLKADNDALKIQLKYAQKKIESLQ
Sbjct: 721 KRAFVKWENKDSLIKSKEELRHLRLPTYQELEQEINTLKADNDALKIQLKYAQKKIESLQ 780
Query: 781 LEKSNHVLAQMEQGDCS 797
LEKSNHVLAQMEQGDCS
Sbjct: 781 LEKSNHVLAQMEQGDCS 797
>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
sapiens]
Length = 762
Score = 1523 bits (3943), Expect = 0.0
Identities = 762/797 (95%), Positives = 762/797 (95%), Gaps = 35/797 (4%)
Query: 1 MGTLGKAREAPRKPSHGCRAASKARLEAKPANSPFPSHPSLAHITQFRMMVSLGHLAKGA 60
MGTLGKAREAPRKPSHGCRAASKARLEAKPANSPFPSHPSLAHITQFRMMVSLGHLAKGA
Sbjct: 1 MGTLGKAREAPRKPSHGCRAASKARLEAKPANSPFPSHPSLAHITQFRMMVSLGHLAKGA 60
Query: 61 SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALAKNSPG 120
SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALAKNSPG
Sbjct: 61 SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALAKNSPG 120
Query: 121 LCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQINARDWS 180
LCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQINARDWS
Sbjct: 121 LCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQINARDWS 180
Query: 181 RKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKE 240
RKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKE
Sbjct: 181 RKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKE 240
Query: 241 NPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGG 300
NPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGG
Sbjct: 241 NPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGG 300
Query: 301 LCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLK 360
LCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLK
Sbjct: 301 LCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLK 360
Query: 361 DLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLY 420
DLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLY
Sbjct: 361 DLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLY 420
Query: 421 YTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFK 480
YTEDEIYELSYAREPRNHRAP SVFK
Sbjct: 421 YTEDEIYELSYAREPRNHRAP-----------------------------------SVFK 445
Query: 481 NYDHDQDGYISQEEFEKIAASFPFSFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGF 540
NYDHDQDGYISQEEFEKIAASFPFSFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGF
Sbjct: 446 NYDHDQDGYISQEEFEKIAASFPFSFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGF 505
Query: 541 PHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRAKNPVA 600
PHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRAKNPVA
Sbjct: 506 PHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRAKNPVA 565
Query: 601 PTENNTSVGPVSNLCSLGAKDLLHAPEEGPFTFPNGEAVEHGEESKDRTIMLMGVSSQKI 660
PTENNTSVGPVSNLCSLGAKDLLHAPEEGPFTFPNGEAVEHGEESKDRTIMLMGVSSQKI
Sbjct: 566 PTENNTSVGPVSNLCSLGAKDLLHAPEEGPFTFPNGEAVEHGEESKDRTIMLMGVSSQKI 625
Query: 661 SLRLKRAVAHKATQTESQPWIGSEGPSGPFVLSSPRKTAQDTLYVLPSPTSPCPSPVLVR 720
SLRLKRAVAHKATQTESQPWIGSEGPSGPFVLSSPRKTAQDTLYVLPSPTSPCPSPVLVR
Sbjct: 626 SLRLKRAVAHKATQTESQPWIGSEGPSGPFVLSSPRKTAQDTLYVLPSPTSPCPSPVLVR 685
Query: 721 KRAFVKWENKDSLIKSKEELRHLRLPTYQELEQEINTLKADNDALKIQLKYAQKKIESLQ 780
KRAFVKWENKDSLIKSKEELRHLRLPTYQELEQEINTLKADNDALKIQLKYAQKKIESLQ
Sbjct: 686 KRAFVKWENKDSLIKSKEELRHLRLPTYQELEQEINTLKADNDALKIQLKYAQKKIESLQ 745
Query: 781 LEKSNHVLAQMEQGDCS 797
LEKSNHVLAQMEQGDCS
Sbjct: 746 LEKSNHVLAQMEQGDCS 762
>gi|7662334 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 2 [Homo sapiens]
Length = 689
Score = 692 bits (1786), Expect = 0.0
Identities = 363/680 (53%), Positives = 472/680 (69%), Gaps = 35/680 (5%)
Query: 56 LAKGASLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALA 115
L K A+LD+L+ +CI+ FD +G L S L +++L MHR +SS EL +K++ +Y++A
Sbjct: 6 LGKAATLDELLCTCIEMFDDNGELDNS-YLPRIVLLMHRWYLSSTELAEKLLCMYRNATG 64
Query: 116 KNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQIN 175
++ LKICYF+RYWI +F F +D L EEF+E+ G E H LID + I
Sbjct: 65 ESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSIP 124
Query: 176 ARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVN 235
+ DW R++TQR K SKK K LLFDHLEP EL+EHLT+LE KSFRRISF+DYQ+Y+++
Sbjct: 125 SYDWMRRVTQRKK--VSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIH 182
Query: 236 SCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLM 295
C++ NPT+ERSIAL NGIS+WVQLMVLS+PTPQ RAEV KFI VA+KL QL+NFNTLM
Sbjct: 183 GCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLM 242
Query: 296 AVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPIL 355
AV+GGL HSSISRLKET SH+ E+ K EMTEL+SS+ NY NYR+A+ +C FKIPIL
Sbjct: 243 AVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPIL 302
Query: 356 GVHLKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTL 415
GVHLKDLI+++ PD+ E+ KVN+ K+ L +SELV LQ + LE N DL++LLTL
Sbjct: 303 GVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTL 362
Query: 416 SLDLYYTEDEIYELSYAREPRNHRAP--PLTPSKPPVVVDWASGVSPKPDPKTISKHVQR 473
SLDLY+TED+IY+LS EPRN ++P P TP+KP V ++WA GV PKPDP I+KH+++
Sbjct: 363 SLDLYHTEDDIYKLSLVLEPRNSKSPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRK 422
Query: 474 MVDSVFKNYDHDQDGYISQEEFEKIAASFPF--SFCVMDKDREGLISRDEITAYFMRA-S 530
+V+SVF+NYDHD DGYISQE+FE IAA+FPF SFCV+DKD++GLIS+DE+ AYF+RA S
Sbjct: 423 LVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKS 482
Query: 531 SIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFE 590
++ K+G GF HNFQE TYLKPTFC++CAGFLWG+IKQGY+CKDCG NCHKQCKDL+V
Sbjct: 483 QLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLA 542
Query: 591 CKKRAKNPVAPTENNTSVGPVSNLCSLGAKDLLHAPEEGPFTFPNGEAVEHGEESKDRTI 650
C++ A+ P + + + G S L ++ F FP A +S R I
Sbjct: 543 CRRFARAPSLSSGHGSLPGSPS----------LPPAQDEVFEFPGVTAGHRDLDS--RAI 590
Query: 651 MLMGVSSQKISLRLKRAVAHKATQTESQPWIGSEGPSGPFVLSSPRKTAQDTLYVLPSPT 710
L+ SS+KIS+RL+RA +ATQTE G SG + D
Sbjct: 591 TLVTGSSRKISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDK-------- 642
Query: 711 SPCPSPVLVRKRAFVKWENK 730
+ + F KWEN+
Sbjct: 643 -------AAKDKGFAKWENE 655
>gi|213385270 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 689 bits (1777), Expect = 0.0
Identities = 362/681 (53%), Positives = 471/681 (69%), Gaps = 36/681 (5%)
Query: 56 LAKGASLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALA 115
L K A+LD+L+ +CI+ FD +G L S L +++L MHR +SS EL +K++ +Y++A
Sbjct: 6 LGKAATLDELLCTCIEMFDDNGELDNS-YLPRIVLLMHRWYLSSTELAEKLLCMYRNATG 64
Query: 116 KNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQIN 175
++ LKICYF+RYWI +F F +D L EEF+E+ G E H LID + I
Sbjct: 65 ESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSIP 124
Query: 176 ARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVN 235
+ DW R++TQR K SKK K LLFDHLEP EL+EHLT+LE KSFRRISF+DYQ+Y+++
Sbjct: 125 SYDWMRRVTQRKK--VSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIH 182
Query: 236 SCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLM 295
C++ NPT+ERSIAL NGIS+WVQLMVLS+PTPQ RAEV KFI VA+KL QL+NFNTLM
Sbjct: 183 GCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLM 242
Query: 296 AVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPIL 355
AV+GGL HSSISRLKET SH+ E+ K EMTEL+SS+ NY NYR+A+ +C FKIPIL
Sbjct: 243 AVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPIL 302
Query: 356 GVHLKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTL 415
GVHLKDLI+++ PD+ E+ KVN+ K+ L +SELV LQ + LE N DL++LLTL
Sbjct: 303 GVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTL 362
Query: 416 SLDLYYTEDEIYELSYAREPRNHRA---PPLTPSKPPVVVDWASGVSPKPDPKTISKHVQ 472
SLDLY+TED+IY+LS EPRN ++ P TP+KP V ++WA GV PKPDP I+KH++
Sbjct: 363 SLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIR 422
Query: 473 RMVDSVFKNYDHDQDGYISQEEFEKIAASFPF--SFCVMDKDREGLISRDEITAYFMRA- 529
++V+SVF+NYDHD DGYISQE+FE IAA+FPF SFCV+DKD++GLIS+DE+ AYF+RA
Sbjct: 423 KLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAK 482
Query: 530 SSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVF 589
S ++ K+G GF HNFQE TYLKPTFC++CAGFLWG+IKQGY+CKDCG NCHKQCKDL+V
Sbjct: 483 SQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVL 542
Query: 590 ECKKRAKNPVAPTENNTSVGPVSNLCSLGAKDLLHAPEEGPFTFPNGEAVEHGEESKDRT 649
C++ A+ P + + + G S L ++ F FP A +S R
Sbjct: 543 ACRRFARAPSLSSGHGSLPGSPS----------LPPAQDEVFEFPGVTAGHRDLDS--RA 590
Query: 650 IMLMGVSSQKISLRLKRAVAHKATQTESQPWIGSEGPSGPFVLSSPRKTAQDTLYVLPSP 709
I L+ SS+KIS+RL+RA +ATQTE G SG + D
Sbjct: 591 ITLVTGSSRKISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDK------- 643
Query: 710 TSPCPSPVLVRKRAFVKWENK 730
+ + F KWEN+
Sbjct: 644 --------AAKDKGFAKWENE 656
>gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 689 bits (1777), Expect = 0.0
Identities = 362/681 (53%), Positives = 471/681 (69%), Gaps = 36/681 (5%)
Query: 56 LAKGASLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALA 115
L K A+LD+L+ +CI+ FD +G L S L +++L MHR +SS EL +K++ +Y++A
Sbjct: 6 LGKAATLDELLCTCIEMFDDNGELDNS-YLPRIVLLMHRWYLSSTELAEKLLCMYRNATG 64
Query: 116 KNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQIN 175
++ LKICYF+RYWI +F F +D L EEF+E+ G E H LID + I
Sbjct: 65 ESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSIP 124
Query: 176 ARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVN 235
+ DW R++TQR K SKK K LLFDHLEP EL+EHLT+LE KSFRRISF+DYQ+Y+++
Sbjct: 125 SYDWMRRVTQRKK--VSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIH 182
Query: 236 SCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLM 295
C++ NPT+ERSIAL NGIS+WVQLMVLS+PTPQ RAEV KFI VA+KL QL+NFNTLM
Sbjct: 183 GCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLM 242
Query: 296 AVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPIL 355
AV+GGL HSSISRLKET SH+ E+ K EMTEL+SS+ NY NYR+A+ +C FKIPIL
Sbjct: 243 AVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPIL 302
Query: 356 GVHLKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTL 415
GVHLKDLI+++ PD+ E+ KVN+ K+ L +SELV LQ + LE N DL++LLTL
Sbjct: 303 GVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTL 362
Query: 416 SLDLYYTEDEIYELSYAREPRNHRA---PPLTPSKPPVVVDWASGVSPKPDPKTISKHVQ 472
SLDLY+TED+IY+LS EPRN ++ P TP+KP V ++WA GV PKPDP I+KH++
Sbjct: 363 SLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIR 422
Query: 473 RMVDSVFKNYDHDQDGYISQEEFEKIAASFPF--SFCVMDKDREGLISRDEITAYFMRA- 529
++V+SVF+NYDHD DGYISQE+FE IAA+FPF SFCV+DKD++GLIS+DE+ AYF+RA
Sbjct: 423 KLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAK 482
Query: 530 SSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVF 589
S ++ K+G GF HNFQE TYLKPTFC++CAGFLWG+IKQGY+CKDCG NCHKQCKDL+V
Sbjct: 483 SQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVL 542
Query: 590 ECKKRAKNPVAPTENNTSVGPVSNLCSLGAKDLLHAPEEGPFTFPNGEAVEHGEESKDRT 649
C++ A+ P + + + G S L ++ F FP A +S R
Sbjct: 543 ACRRFARAPSLSSGHGSLPGSPS----------LPPAQDEVFEFPGVTAGHRDLDS--RA 590
Query: 650 IMLMGVSSQKISLRLKRAVAHKATQTESQPWIGSEGPSGPFVLSSPRKTAQDTLYVLPSP 709
I L+ SS+KIS+RL+RA +ATQTE G SG + D
Sbjct: 591 ITLVTGSSRKISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDK------- 643
Query: 710 TSPCPSPVLVRKRAFVKWENK 730
+ + F KWEN+
Sbjct: 644 --------AAKDKGFAKWENE 656
>gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]
Length = 673
Score = 564 bits (1453), Expect = e-160
Identities = 285/569 (50%), Positives = 388/569 (68%), Gaps = 6/569 (1%)
Query: 39 PSLAHITQFRMMVSLGHLAKGA-SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVI 97
PS I++ ++LG L++G S D+L++ CIQSFD+ G+LC + +L ++L MH V+
Sbjct: 34 PSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVL 93
Query: 98 SSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELV 157
SA+L +++T Y+ A L+IC+ VRYW+ + D L + + F V
Sbjct: 94 PSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATV 153
Query: 158 KAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLE 217
+G RL D++ + + KKRKVSLLFDHLE EL++HLTYLE
Sbjct: 154 AREGNSAQRRLGDSSDLLSPGGPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLE 213
Query: 218 FKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIK 277
F+SF+ I+ D ++Y++ V+ P +E S+ L N +S+WVQ+MVLSRP P RA+V K
Sbjct: 214 FRSFQAITPQDLRSYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDK 273
Query: 278 FIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNY 337
FI VAQ+LHQLQNFNTLMAV GGLCHS+ISRLK++ +H+ + K L E+TELL+S NY
Sbjct: 274 FIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNY 333
Query: 338 DNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQ 397
YRR + C F++P+LGVHLKDL+SL+EA PD L DG++++ KL LY + ELV LQ
Sbjct: 334 ARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQ 393
Query: 398 EVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASG 457
PP AN+DL+HLLTLSLDL+YTEDEIYELSYAREPR ++ P +P P+VV+WA G
Sbjct: 394 GQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPG 453
Query: 458 VSPKPDPKTISKHVQRMVDSVFKNYDHDQDGYISQEEFEKIAASFPFSFCVM---DKDRE 514
V+PKPD T+ +HV+++V+SVFKNYD + G ISQE+FE+++ +FPF+ + +
Sbjct: 454 VTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGR 513
Query: 515 GLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKD 574
G SR+E+T Y +RAS+I SKLGL F H F E T+ KPTFCD+C+GFLWGV KQGYRC++
Sbjct: 514 GSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRE 573
Query: 575 CGMNCHKQCKDLVVFECKKR--AKNPVAP 601
CG+ CHK C+D V ECKKR AK P
Sbjct: 574 CGLCCHKHCRDQVKVECKKRPGAKGDAGP 602
>gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo
sapiens]
Length = 659
Score = 561 bits (1447), Expect = e-160
Identities = 285/569 (50%), Positives = 387/569 (68%), Gaps = 20/569 (3%)
Query: 39 PSLAHITQFRMMVSLGHLAKGA-SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVI 97
PS I++ ++LG L++G S D+L++ CIQSFD+ G+LC + +L ++L MH V+
Sbjct: 34 PSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVL 93
Query: 98 SSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELV 157
SA+L +++T Y+ A L+IC+ VRYW+ + D L + + F V
Sbjct: 94 PSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATV 153
Query: 158 KAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLE 217
+G RL D++ + KKRKVSLLFDHLE EL++HLTYLE
Sbjct: 154 AREGNSAQRRLGDSSDL--------------PGLGKKRKVSLLFDHLETGELAQHLTYLE 199
Query: 218 FKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIK 277
F+SF+ I+ D ++Y++ V+ P +E S+ L N +S+WVQ+MVLSRP P RA+V K
Sbjct: 200 FRSFQAITPQDLRSYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDK 259
Query: 278 FIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNY 337
FI VAQ+LHQLQNFNTLMAV GGLCHS+ISRLK++ +H+ + K L E+TELL+S NY
Sbjct: 260 FIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNY 319
Query: 338 DNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQ 397
YRR + C F++P+LGVHLKDL+SL+EA PD L DG++++ KL LY + ELV LQ
Sbjct: 320 ARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQ 379
Query: 398 EVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASG 457
PP AN+DL+HLLTLSLDL+YTEDEIYELSYAREPR ++ P +P P+VV+WA G
Sbjct: 380 GQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPG 439
Query: 458 VSPKPDPKTISKHVQRMVDSVFKNYDHDQDGYISQEEFEKIAASFPFSFCVM---DKDRE 514
V+PKPD T+ +HV+++V+SVFKNYD + G ISQE+FE+++ +FPF+ + +
Sbjct: 440 VTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGR 499
Query: 515 GLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKD 574
G SR+E+T Y +RAS+I SKLGL F H F E T+ KPTFCD+C+GFLWGV KQGYRC++
Sbjct: 500 GSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRE 559
Query: 575 CGMNCHKQCKDLVVFECKKR--AKNPVAP 601
CG+ CHK C+D V ECKKR AK P
Sbjct: 560 CGLCCHKHCRDQVKVECKKRPGAKGDAGP 588
>gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo
sapiens]
Length = 639
Score = 520 bits (1340), Expect = e-147
Identities = 273/569 (47%), Positives = 367/569 (64%), Gaps = 40/569 (7%)
Query: 39 PSLAHITQFRMMVSLGHLAKGA-SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVI 97
PS I++ ++LG L++G S D+L++ CIQSFD+ G+LC + +L ++L MH V+
Sbjct: 34 PSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVL 93
Query: 98 SSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELV 157
SA+L +++T Y+ A L+IC+ VRYW+ + D L + + F V
Sbjct: 94 PSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATV 153
Query: 158 KAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLE 217
+G RL D++ + + KKRKVSLLFDHLE EL++HLTYLE
Sbjct: 154 AREGNSAQRRLGDSSDLLSPGGPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLE 213
Query: 218 FKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIK 277
F+SF+ I+ +MVLSRP P RA+V K
Sbjct: 214 FRSFQAIT----------------------------------VMVLSRPGPLQRAQVLDK 239
Query: 278 FIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNY 337
FI VAQ+LHQLQNFNTLMAV GGLCHS+ISRLK++ +H+ + K L E+TELL+S NY
Sbjct: 240 FIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNY 299
Query: 338 DNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQ 397
YRR + C F++P+LGVHLKDL+SL+EA PD L DG++++ KL LY + ELV LQ
Sbjct: 300 ARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQ 359
Query: 398 EVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASG 457
PP AN+DL+HLLTLSLDL+YTEDEIYELSYAREPR ++ P +P P+VV+WA G
Sbjct: 360 GQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPG 419
Query: 458 VSPKPDPKTISKHVQRMVDSVFKNYDHDQDGYISQEEFEKIAASFPFSFCVM---DKDRE 514
V+PKPD T+ +HV+++V+SVFKNYD + G ISQE+FE+++ +FPF+ + +
Sbjct: 420 VTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGR 479
Query: 515 GLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKD 574
G SR+E+T Y +RAS+I SKLGL F H F E T+ KPTFCD+C+GFLWGV KQGYRC++
Sbjct: 480 GSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRE 539
Query: 575 CGMNCHKQCKDLVVFECKKR--AKNPVAP 601
CG+ CHK C+D V ECKKR AK P
Sbjct: 540 CGLCCHKHCRDQVKVECKKRPGAKGDAGP 568
>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 515 bits (1327), Expect = e-146
Identities = 256/551 (46%), Positives = 375/551 (68%), Gaps = 12/551 (2%)
Query: 56 LAKGASLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALA 115
L KG ++++L+ CI++FD G + R QL+++ L MH I S++L K++ +Y+ +
Sbjct: 7 LDKGCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRK 65
Query: 116 KNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQIN 175
NS L +K C+ VRYWI+ F F ++ L + ++E + L+ +G H LID +
Sbjct: 66 DNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDIDSVP 125
Query: 176 ARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVN 235
W R++TQR KKRK+SLLFDHLEP EL+EHLTYLE++SF +I F DY +++ +
Sbjct: 126 TYKWKRQVTQRNPVG-QKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTH 184
Query: 236 SCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLM 295
C +NP +ER I+L N +SQWVQLM+LS+PT RA V F+ VA+KL QLQNFNTLM
Sbjct: 185 GCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLM 244
Query: 296 AVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPIL 355
AV+GGL HSSISRLKET SHV E K+ +TEL++++ NY NYRR C F+ PIL
Sbjct: 245 AVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPIL 304
Query: 356 GVHLKDLISLYEAMPDYLEDG--KVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLL 413
GVHLKDL++L A+PD+L+ ++N K+ L++ + EL + + PP++AN DL+ LL
Sbjct: 305 GVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLL 364
Query: 414 TLSLDLYYTEDEIYELSYAREPRNHRAPP-----LTPSKPPVVVDWASGVSPKPDPKTIS 468
T+SLD Y TEDE+Y+LS REPR+ +P P +PPV+ +W S PK D +
Sbjct: 365 TVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVV 424
Query: 469 KHVQRMVDSVFKNYDHDQDGYISQEEFEKIAASFPF--SFCVMDKDREGLISRDEITAYF 526
+H+++MV+SVF+N+D D DG+ISQEEF+ I +FP+ +F +D++++G ISR+E+ +YF
Sbjct: 425 EHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEMVSYF 484
Query: 527 MRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDL 586
+R+SS+ +GF HNFQE+ L+P C +C + G+ KQG +C+ CG+NCHKQCKD
Sbjct: 485 LRSSSVLGG-RMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDR 543
Query: 587 VVFECKKRAKN 597
+ EC++RA++
Sbjct: 544 LSVECRRRAQS 554
>gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 515 bits (1327), Expect = e-146
Identities = 256/551 (46%), Positives = 375/551 (68%), Gaps = 12/551 (2%)
Query: 56 LAKGASLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALA 115
L KG ++++L+ CI++FD G + R QL+++ L MH I S++L K++ +Y+ +
Sbjct: 7 LDKGCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRK 65
Query: 116 KNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQIN 175
NS L +K C+ VRYWI+ F F ++ L + ++E + L+ +G H LID +
Sbjct: 66 DNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDIDSVP 125
Query: 176 ARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVN 235
W R++TQR KKRK+SLLFDHLEP EL+EHLTYLE++SF +I F DY +++ +
Sbjct: 126 TYKWKRQVTQRNPVG-QKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTH 184
Query: 236 SCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLM 295
C +NP +ER I+L N +SQWVQLM+LS+PT RA V F+ VA+KL QLQNFNTLM
Sbjct: 185 GCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLM 244
Query: 296 AVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPIL 355
AV+GGL HSSISRLKET SHV E K+ +TEL++++ NY NYRR C F+ PIL
Sbjct: 245 AVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPIL 304
Query: 356 GVHLKDLISLYEAMPDYLEDG--KVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLL 413
GVHLKDL++L A+PD+L+ ++N K+ L++ + EL + + PP++AN DL+ LL
Sbjct: 305 GVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLL 364
Query: 414 TLSLDLYYTEDEIYELSYAREPRNHRAPP-----LTPSKPPVVVDWASGVSPKPDPKTIS 468
T+SLD Y TEDE+Y+LS REPR+ +P P +PPV+ +W S PK D +
Sbjct: 365 TVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVV 424
Query: 469 KHVQRMVDSVFKNYDHDQDGYISQEEFEKIAASFPF--SFCVMDKDREGLISRDEITAYF 526
+H+++MV+SVF+N+D D DG+ISQEEF+ I +FP+ +F +D++++G ISR+E+ +YF
Sbjct: 425 EHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEMVSYF 484
Query: 527 MRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDL 586
+R+SS+ +GF HNFQE+ L+P C +C + G+ KQG +C+ CG+NCHKQCKD
Sbjct: 485 LRSSSVLGG-RMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDR 543
Query: 587 VVFECKKRAKN 597
+ EC++RA++
Sbjct: 544 LSVECRRRAQS 554
>gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 515 bits (1327), Expect = e-146
Identities = 256/551 (46%), Positives = 375/551 (68%), Gaps = 12/551 (2%)
Query: 56 LAKGASLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALA 115
L KG ++++L+ CI++FD G + R QL+++ L MH I S++L K++ +Y+ +
Sbjct: 7 LDKGCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRK 65
Query: 116 KNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQIN 175
NS L +K C+ VRYWI+ F F ++ L + ++E + L+ +G H LID +
Sbjct: 66 DNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDIDSVP 125
Query: 176 ARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVN 235
W R++TQR KKRK+SLLFDHLEP EL+EHLTYLE++SF +I F DY +++ +
Sbjct: 126 TYKWKRQVTQRNPVG-QKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTH 184
Query: 236 SCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLM 295
C +NP +ER I+L N +SQWVQLM+LS+PT RA V F+ VA+KL QLQNFNTLM
Sbjct: 185 GCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLM 244
Query: 296 AVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPIL 355
AV+GGL HSSISRLKET SHV E K+ +TEL++++ NY NYRR C F+ PIL
Sbjct: 245 AVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPIL 304
Query: 356 GVHLKDLISLYEAMPDYLEDG--KVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLL 413
GVHLKDL++L A+PD+L+ ++N K+ L++ + EL + + PP++AN DL+ LL
Sbjct: 305 GVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLL 364
Query: 414 TLSLDLYYTEDEIYELSYAREPRNHRAPP-----LTPSKPPVVVDWASGVSPKPDPKTIS 468
T+SLD Y TEDE+Y+LS REPR+ +P P +PPV+ +W S PK D +
Sbjct: 365 TVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVV 424
Query: 469 KHVQRMVDSVFKNYDHDQDGYISQEEFEKIAASFPF--SFCVMDKDREGLISRDEITAYF 526
+H+++MV+SVF+N+D D DG+ISQEEF+ I +FP+ +F +D++++G ISR+E+ +YF
Sbjct: 425 EHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEMVSYF 484
Query: 527 MRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDL 586
+R+SS+ +GF HNFQE+ L+P C +C + G+ KQG +C+ CG+NCHKQCKD
Sbjct: 485 LRSSSVLGG-RMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDR 543
Query: 587 VVFECKKRAKN 597
+ EC++RA++
Sbjct: 544 LSVECRRRAQS 554
>gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo
sapiens]
Length = 576
Score = 335 bits (858), Expect = 1e-91
Identities = 160/281 (56%), Positives = 208/281 (74%), Gaps = 5/281 (1%)
Query: 326 EMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVHKLLA 385
E+TELL+S NY YRR + C F++P+LGVHLKDL+SL+EA PD L DG++++ KL
Sbjct: 225 ELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNN 284
Query: 386 LYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTP 445
LY + ELV LQ PP AN+DL+HLLTLSLDL+YTEDEIYELSYAREPR ++ P +P
Sbjct: 285 LYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSP 344
Query: 446 SKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDHDQDGYISQEEFEKIAASFPFS 505
P+VV+WA GV+PKPD T+ +HV+++V+SVFKNYD + G ISQE+FE+++ +FPF+
Sbjct: 345 FNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFA 404
Query: 506 FCVM---DKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFL 562
+ + G SR+E+T Y +RAS+I SKLGL F H F E T+ KPTFCD+C+GFL
Sbjct: 405 CHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFL 464
Query: 563 WGVIKQGYRCKDCGMNCHKQCKDLVVFECKKR--AKNPVAP 601
WGV KQGYRC++CG+ CHK C+D V ECKKR AK P
Sbjct: 465 WGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGP 505
Score = 125 bits (315), Expect = 1e-28
Identities = 70/188 (37%), Positives = 107/188 (56%), Gaps = 1/188 (0%)
Query: 39 PSLAHITQFRMMVSLGHLAKGA-SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVI 97
PS I++ ++LG L++G S D+L++ CIQSFD+ G+LC + +L ++L MH V+
Sbjct: 34 PSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVL 93
Query: 98 SSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELV 157
SA+L +++T Y+ A L+IC+ VRYW+ + D L + + F V
Sbjct: 94 PSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATV 153
Query: 158 KAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLE 217
+G RL D++ + + KKRKVSLLFDHLE EL++HLTYLE
Sbjct: 154 AREGNSAQRRLGDSSDLLSPGGPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLE 213
Query: 218 FKSFRRIS 225
F+SF+ I+
Sbjct: 214 FRSFQAIT 221
>gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo
sapiens]
Length = 604
Score = 261 bits (667), Expect = 2e-69
Identities = 125/215 (58%), Positives = 160/215 (74%), Gaps = 5/215 (2%)
Query: 392 ELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVV 451
ELV LQ PP AN+DL+HLLTLSLDL+YTEDEIYELSYAREPR ++ P +P P+V
Sbjct: 319 ELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLV 378
Query: 452 VDWASGVSPKPDPKTISKHVQRMVDSVFKNYDHDQDGYISQEEFEKIAASFPFSFCVM-- 509
V+WA GV+PKPD T+ +HV+++V+SVFKNYD + G ISQE+FE+++ +FPF+ +
Sbjct: 379 VEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHP 438
Query: 510 -DKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQ 568
+ G SR+E+T Y +RAS+I SKLGL F H F E T+ KPTFCD+C+GFLWGV KQ
Sbjct: 439 PPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQ 498
Query: 569 GYRCKDCGMNCHKQCKDLVVFECKKR--AKNPVAP 601
GYRC++CG+ CHK C+D V ECKKR AK P
Sbjct: 499 GYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGP 533
Score = 234 bits (597), Expect = 2e-61
Identities = 125/287 (43%), Positives = 180/287 (62%), Gaps = 1/287 (0%)
Query: 39 PSLAHITQFRMMVSLGHLAKGA-SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVI 97
PS I++ ++LG L++G S D+L++ CIQSFD+ G+LC + +L ++L MH V+
Sbjct: 34 PSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVL 93
Query: 98 SSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELV 157
SA+L +++T Y+ A L+IC+ VRYW+ + D L + + F V
Sbjct: 94 PSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATV 153
Query: 158 KAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLE 217
+G RL D++ + + KKRKVSLLFDHLE EL++HLTYLE
Sbjct: 154 AREGNSAQRRLGDSSDLLSPGGPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLE 213
Query: 218 FKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIK 277
F+SF+ I+ D ++Y++ V+ P +E S+ L N +S+WVQ+MVLSRP P RA+V K
Sbjct: 214 FRSFQAITPQDLRSYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDK 273
Query: 278 FIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVL 324
FI VAQ+LHQLQNFNTLMAV GGLCHS+ISRLK++ +H+ + K L
Sbjct: 274 FIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKEL 320
>gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo
sapiens]
Length = 484
Score = 237 bits (604), Expect = 4e-62
Identities = 118/225 (52%), Positives = 158/225 (70%), Gaps = 8/225 (3%)
Query: 382 KLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAP 441
K+ L++H+ E +L + LE +TLSLDL+YTEDEIYELSYAREPR ++
Sbjct: 192 KVSLLFDHL-ETGELAQHLTYLEFRS--FQAITLSLDLFYTEDEIYELSYAREPRCPKSL 248
Query: 442 PLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDHDQDGYISQEEFEKIAAS 501
P +P P+VV+WA GV+PKPD T+ +HV+++V+SVFKNYD + G ISQE+FE+++ +
Sbjct: 249 PPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGN 308
Query: 502 FPFSFCVM---DKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNC 558
FPF+ + + G SR+E+T Y +RAS+I SKLGL F H F E T+ KPTFCD+C
Sbjct: 309 FPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSC 368
Query: 559 AGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKR--AKNPVAP 601
+GFLWGV KQGYRC++CG+ CHK C+D V ECKKR AK P
Sbjct: 369 SGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGP 413
Score = 127 bits (319), Expect = 4e-29
Identities = 71/190 (37%), Positives = 108/190 (56%), Gaps = 1/190 (0%)
Query: 39 PSLAHITQFRMMVSLGHLAKGA-SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVI 97
PS I++ ++LG L++G S D+L++ CIQSFD+ G+LC + +L ++L MH V+
Sbjct: 34 PSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVL 93
Query: 98 SSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELV 157
SA+L +++T Y+ A L+IC+ VRYW+ + D L + + F V
Sbjct: 94 PSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATV 153
Query: 158 KAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLE 217
+G RL D++ + + KKRKVSLLFDHLE EL++HLTYLE
Sbjct: 154 AREGNSAQRRLGDSSDLLSPGGPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLE 213
Query: 218 FKSFRRISFS 227
F+SF+ I+ S
Sbjct: 214 FRSFQAITLS 223
>gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo
sapiens]
Length = 581
Score = 234 bits (596), Expect = 3e-61
Identities = 124/286 (43%), Positives = 180/286 (62%), Gaps = 1/286 (0%)
Query: 39 PSLAHITQFRMMVSLGHLAKGA-SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVI 97
PS I++ ++LG L++G S D+L++ CIQSFD+ G+LC + +L ++L MH V+
Sbjct: 34 PSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVL 93
Query: 98 SSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELV 157
SA+L +++T Y+ A L+IC+ VRYW+ + D L + + F V
Sbjct: 94 PSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATV 153
Query: 158 KAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLE 217
+G RL D++ + + KKRKVSLLFDHLE EL++HLTYLE
Sbjct: 154 AREGNSAQRRLGDSSDLLSPGGPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLE 213
Query: 218 FKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIK 277
F+SF+ I+ D ++Y++ V+ P +E S+ L N +S+WVQ+MVLSRP P RA+V K
Sbjct: 214 FRSFQAITPQDLRSYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDK 273
Query: 278 FIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKV 323
FI VAQ+LHQLQNFNTLMAV GGLCHS+ISRLK++ +H+ + K+
Sbjct: 274 FIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKL 319
Score = 234 bits (596), Expect = 3e-61
Identities = 110/192 (57%), Positives = 143/192 (74%), Gaps = 5/192 (2%)
Query: 415 LSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRM 474
LSLDL+YTEDEIYELSYAREPR ++ P +P P+VV+WA GV+PKPD T+ +HV+++
Sbjct: 319 LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL 378
Query: 475 VDSVFKNYDHDQDGYISQEEFEKIAASFPFSFCVMD---KDREGLISRDEITAYFMRASS 531
V+SVFKNYD + G ISQE+FE+++ +FPF+ + + G SR+E+T Y +RAS+
Sbjct: 379 VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA 438
Query: 532 IYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFEC 591
I SKLGL F H F E T+ KPTFCD+C+GFLWGV KQGYRC++CG+ CHK C+D V EC
Sbjct: 439 ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 498
Query: 592 KKR--AKNPVAP 601
KKR AK P
Sbjct: 499 KKRPGAKGDAGP 510
>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
sapiens]
Length = 1095
Score = 105 bits (263), Expect = 1e-22
Identities = 86/356 (24%), Positives = 161/356 (45%), Gaps = 12/356 (3%)
Query: 87 QVMLTMHRIVISSAELLQKVITLYK--DALAKNSPGLCLKICYFVRYWITEFWVMFKMDA 144
+ LT +R IS EL++K+ Y+ A K +FV + + + ++
Sbjct: 735 EAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTE 794
Query: 145 SLTDTMEEFQELVKAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSL---LF 201
+ + E + GE R++ ++ D + L S R V+
Sbjct: 795 EILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPGTL 854
Query: 202 DHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLM 261
E++E LT L+ + F +I + + +++P + + N +S WV+ +
Sbjct: 855 HDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSI 914
Query: 262 VLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEIN 321
++ + Q R + +KFI++ + L +L NFN+ +A++ L + I RL+ + +
Sbjct: 915 IMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQK-----QTS 969
Query: 322 KVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVH 381
+ L E L+ SS ++ YR A E IP LG+ L+DL ++ PDY+ DGKVN
Sbjct: 970 EGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYI-DGKVNFS 1028
Query: 382 KLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRN 437
K +N + + Q+ + N D+++ D + E+ ++ELS +PRN
Sbjct: 1029 KRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSD-HLAEEALWELSLKIKPRN 1083
>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
sapiens]
Length = 1077
Score = 105 bits (263), Expect = 1e-22
Identities = 86/356 (24%), Positives = 161/356 (45%), Gaps = 12/356 (3%)
Query: 87 QVMLTMHRIVISSAELLQKVITLYK--DALAKNSPGLCLKICYFVRYWITEFWVMFKMDA 144
+ LT +R IS EL++K+ Y+ A K +FV + + + ++
Sbjct: 717 EAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTE 776
Query: 145 SLTDTMEEFQELVKAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSL---LF 201
+ + E + GE R++ ++ D + L S R V+
Sbjct: 777 EILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPGTL 836
Query: 202 DHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLM 261
E++E LT L+ + F +I + + +++P + + N +S WV+ +
Sbjct: 837 HDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSI 896
Query: 262 VLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEIN 321
++ + Q R + +KFI++ + L +L NFN+ +A++ L + I RL+ + +
Sbjct: 897 IMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQK-----QTS 951
Query: 322 KVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVH 381
+ L E L+ SS ++ YR A E IP LG+ L+DL ++ PDY+ DGKVN
Sbjct: 952 EGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYI-DGKVNFS 1010
Query: 382 KLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRN 437
K +N + + Q+ + N D+++ D + E+ ++ELS +PRN
Sbjct: 1011 KRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSD-HLAEEALWELSLKIKPRN 1065
>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
2 [Homo sapiens]
Length = 1237
Score = 103 bits (256), Expect = 8e-22
Identities = 66/238 (27%), Positives = 117/238 (49%), Gaps = 3/238 (1%)
Query: 201 FDHLEPEELSEHLTYLEFKSFRRISFSDY--QNYLVNSCVKENPTMERSIALCNGISQWV 258
F+ L EL+E +T L+ FR I + ++ Q ++ + P + ++ N +S V
Sbjct: 998 FESLSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLV 1057
Query: 259 QLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPH 318
+++ RA K++ VA L N+N ++ + L S+I RLK+T + V
Sbjct: 1058 ASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSK 1117
Query: 319 EINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKV 378
+ ++ ++ + +SS + N R C +P LG++L DL + E P++ E+G V
Sbjct: 1118 QTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLV 1177
Query: 379 NVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPR 436
N K+ + + I E+ Q Q+ + ++ + L L DL ED +YELS EPR
Sbjct: 1178 NFSKMRMISHIIREIRQFQQTSYRIDHQPKVAQYL-LDKDLIIDEDTLYELSLKIEPR 1234
>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 3 [Homo sapiens]
Length = 1257
Score = 98.2 bits (243), Expect = 3e-20
Identities = 63/238 (26%), Positives = 114/238 (47%), Gaps = 3/238 (1%)
Query: 201 FDHLEPEELSEHLTYLEFKSFRRISFSDY--QNYLVNSCVKENPTMERSIALCNGISQWV 258
F++ E++E LT L+ F++I + ++ Q ++ + P + ++ N IS +
Sbjct: 1018 FENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLI 1077
Query: 259 QLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPH 318
++ R K++ VA L N+N ++ + + S+I RLK+T V
Sbjct: 1078 ASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSK 1137
Query: 319 EINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKV 378
+ ++ ++ +L+SS + N R A C +P LG++L DL + E P+Y EDG V
Sbjct: 1138 QTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLV 1197
Query: 379 NVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPR 436
N K+ + + I E+ Q Q+ A +E + L L E+ +YE S EP+
Sbjct: 1198 NFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL-LDQSFVMDEESLYESSLRIEPK 1254
>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 1 [Homo sapiens]
Length = 1273
Score = 98.2 bits (243), Expect = 3e-20
Identities = 63/238 (26%), Positives = 114/238 (47%), Gaps = 3/238 (1%)
Query: 201 FDHLEPEELSEHLTYLEFKSFRRISFSDY--QNYLVNSCVKENPTMERSIALCNGISQWV 258
F++ E++E LT L+ F++I + ++ Q ++ + P + ++ N IS +
Sbjct: 1034 FENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLI 1093
Query: 259 QLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPH 318
++ R K++ VA L N+N ++ + + S+I RLK+T V
Sbjct: 1094 ASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSK 1153
Query: 319 EINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKV 378
+ ++ ++ +L+SS + N R A C +P LG++L DL + E P+Y EDG V
Sbjct: 1154 QTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLV 1213
Query: 379 NVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPR 436
N K+ + + I E+ Q Q+ A +E + L L E+ +YE S EP+
Sbjct: 1214 NFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL-LDQSFVMDEESLYESSLRIEPK 1270
>gi|24797101 Ras protein-specific guanine nucleotide-releasing
factor 1 isoform 2 [Homo sapiens]
Length = 489
Score = 98.2 bits (243), Expect = 3e-20
Identities = 63/238 (26%), Positives = 114/238 (47%), Gaps = 3/238 (1%)
Query: 201 FDHLEPEELSEHLTYLEFKSFRRISFSDY--QNYLVNSCVKENPTMERSIALCNGISQWV 258
F++ E++E LT L+ F++I + ++ Q ++ + P + ++ N IS +
Sbjct: 250 FENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLI 309
Query: 259 QLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPH 318
++ R K++ VA L N+N ++ + + S+I RLK+T V
Sbjct: 310 ASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSK 369
Query: 319 EINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKV 378
+ ++ ++ +L+SS + N R A C +P LG++L DL + E P+Y EDG V
Sbjct: 370 QTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLV 429
Query: 379 NVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPR 436
N K+ + + I E+ Q Q+ A +E + L L E+ +YE S EP+
Sbjct: 430 NFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL-LDQSFVMDEESLYESSLRIEPK 486
>gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1
[Homo sapiens]
Length = 456
Score = 90.1 bits (222), Expect = 7e-18
Identities = 63/237 (26%), Positives = 117/237 (49%), Gaps = 7/237 (2%)
Query: 204 LEPEELSEHLTYLEFKSFRRISFSDYQNYLVNS--CVKENPTMERSIALCNGISQWVQLM 261
+EPE+++ HLT ++ FR + ++ +Y+ + +E +E + C+ ++ WV
Sbjct: 217 VEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATE 276
Query: 262 VLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEIN 321
VL P RA++ KFI++A Q Q+ + AV+ GL ++++SRL+ T +P +
Sbjct: 277 VLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFK 336
Query: 322 KVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVH 381
+ + L RN+ +YR + IP + + LKDL L+E L DG VN+
Sbjct: 337 NLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGSKT-LVDGLVNIE 395
Query: 382 KLLALYNHISELVQLQEVAPPLEANKDLVHLLTLS----LDLYYTEDEIYELSYARE 434
KL ++ + + + + L+ HL T + + ++ ++ELSY E
Sbjct: 396 KLHSVAEKVRTIRKYRSRPLCLDMEASPNHLQTKAYVRQFQVIDNQNLLFELSYKLE 452
>gi|22749129 RasGEF domain family, member 1B [Homo sapiens]
Length = 473
Score = 84.3 bits (207), Expect = 4e-16
Identities = 73/258 (28%), Positives = 116/258 (44%), Gaps = 30/258 (11%)
Query: 205 EPEELSEHLTYLEFKSFRRISFSDYQNYLVN--------SCVKENP---TMERSIALCNG 253
+P L++ LT++E + I ++ V SC E +E + N
Sbjct: 205 DPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNR 264
Query: 254 ISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETS 313
+S V + + RA + FI VA++ + NFN+LMA+I G+ S +SRLK+T
Sbjct: 265 LSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTW 324
Query: 314 SHVPHEINKVLGEMTELLSSSRNYDNYR-----------RAYGECTDFKIPILGVHLKDL 362
+ V +L + S N+ NYR A+ IP + +KD+
Sbjct: 325 AKVKTAKFDILEHQ---MDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDI 381
Query: 363 ISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEAN-KDLVHLLTLSLDLYY 421
L E + L +G VN K L +SE + ++V P E + K L +LLT+ + +
Sbjct: 382 YFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQYLLTVPV---F 438
Query: 422 TEDEIYELSYARE-PRNH 438
+ED +Y SY E P NH
Sbjct: 439 SEDALYLASYESEGPENH 456
>gi|40255197 RasGEF domain family, member 1C [Homo sapiens]
Length = 466
Score = 82.8 bits (203), Expect = 1e-15
Identities = 68/254 (26%), Positives = 113/254 (44%), Gaps = 26/254 (10%)
Query: 205 EPEELSEHLTYLEFKSFRRISFSDYQNYLVNS--------CVKENPT-MERSIALCNGIS 255
+P L++ LT++E + R I ++ VN C + + +E + N +
Sbjct: 200 DPYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTSNLEAYVKWFNRLC 259
Query: 256 QWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSH 315
V + + RA+V FI VA++ + NFN+LMA+I G+ S +SRLK+T +
Sbjct: 260 YLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAK 319
Query: 316 VPHEINKVLGEMTELLSSSRNYDNYR-----------RAYGECTDFKIPILGVHLKDLIS 364
V +L + + N+ NYR A+ IP + +KD+
Sbjct: 320 VRTAKFFILEHQ---MDPTGNFCNYRTALRGAAHRSLTAHSSREKIVIPFFSLLIKDIYF 376
Query: 365 LYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTED 424
L E + L +G VN K L L + E + ++V P E + + H L + ++ED
Sbjct: 377 LNEGCANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDASITHYLYTA--PIFSED 434
Query: 425 EIYELSYARE-PRN 437
+Y SY E P N
Sbjct: 435 GLYLASYESESPEN 448
>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
Length = 1333
Score = 82.4 bits (202), Expect = 1e-15
Identities = 90/370 (24%), Positives = 157/370 (42%), Gaps = 31/370 (8%)
Query: 123 LKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGE----ELHCRLIDTTQINARD 178
L++ R+W+ + F+ DA L MEEF V+ K E ++I +I ARD
Sbjct: 687 LRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKI-ARD 745
Query: 179 WS-------RKLTQRIKSNTSKKRKVSLLFD--HLEPEELSEHLTYLEFKSFRRISFSDY 229
+ ++ + S+ + FD L P E++ LT LE +R + S+
Sbjct: 746 NGPGHNITFQSSPPTVEWHISRPGHIET-FDLLTLHPIEIARQLTLLESDLYRAVQPSEL 804
Query: 230 QNYLVNSCVKE--NPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQ 287
+ KE +P + + I ++ W + ++ + R V + I++ Q +
Sbjct: 805 VGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQE 864
Query: 288 LQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGEC 347
L NFN ++ V+ + S + RL T +P K+L E EL S +Y Y
Sbjct: 865 LNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHEL--SEDHYKKYLAKLRSI 922
Query: 348 TDFKIPILGVHLKDLISLYEAMPDYLE-DGK--VNVHKLLALYNHISELVQLQEVAPPLE 404
+P G++L +++ E P+ L+ GK +N K + E+ Q Q L
Sbjct: 923 NPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLR 982
Query: 405 ANKDL------VHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGV 458
D+ ++ + S++ +T D ++ S EPRN + P P K + + GV
Sbjct: 983 VESDIKRFFENLNPMGNSMEKEFT-DYLFNKSLEIEPRNPKPLPRFPKKYSYPLK-SPGV 1040
Query: 459 SP-KPDPKTI 467
P P P T+
Sbjct: 1041 RPSNPRPGTM 1050
>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
sapiens]
Length = 583
Score = 80.5 bits (197), Expect = 6e-15
Identities = 91/345 (26%), Positives = 154/345 (44%), Gaps = 40/345 (11%)
Query: 188 KSNTSKKRKVSLLFDHLE--PEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKEN--PT 243
K + KK +++FD L+ PEE + +T ++ F+ I + + N K + P
Sbjct: 30 KGSELKKSFDAVVFDVLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPN 89
Query: 244 MERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCH 303
N +S WV +L T ++RAEV +I+ A+KL++L N + LMAV+ GL
Sbjct: 90 AVAFTRRFNHVSFWVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQS 149
Query: 304 SSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFK----IPILGVHL 359
+ I RL +T + + + +K E E + S DNY+R + K IP LG++L
Sbjct: 150 APIFRLTKTWALLSRK-DKTTFEKLEYVMSKE--DNYKRLRDYISSLKMTPCIPYLGIYL 206
Query: 360 KDLISLYEAMPD--YLEDGKVNVHKLLALYNHISELVQLQEVAPPL--EANKDLVHLLTL 415
DL + A P + + + + + + IS+L Q E P+ K L + +
Sbjct: 207 SDLTYIDSAYPSTGSILENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYI 266
Query: 416 SLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPK-------------- 461
+ ED+ Y+LS EP + P + + +V G SP+
Sbjct: 267 EELQKFVEDDNYKLSLKIEPGT--STPRSAASREDLVGPEVGASPQSGRKSVAAEGALLP 324
Query: 462 ---PDPKTISKHVQRMVDSVFKNYDHDQDGYISQEEFEKIAASFP 503
P P+ + H R S+ N+ H ++ EF+ +A+FP
Sbjct: 325 QTPPSPRNLIPHGHRKCHSLGYNFIHK----MNTAEFK--SATFP 363
>gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 78.6 bits (192), Expect = 2e-14
Identities = 53/185 (28%), Positives = 95/185 (51%), Gaps = 4/185 (2%)
Query: 202 DHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPT---MERSIALCNGISQWV 258
D + ++L+ LT ++ F I + +Y++ + T +ER + N + WV
Sbjct: 617 DLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWV 676
Query: 259 QLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPH 318
+ P P RA++ KFI++A L + +N N+ AV+ GL +S+ISRL T +PH
Sbjct: 677 ATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPH 736
Query: 319 EINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKV 378
++ K+ + LL S N+ YR A + + IP + + LKD+ ++E +E+ +
Sbjct: 737 KVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVEN-LI 795
Query: 379 NVHKL 383
N K+
Sbjct: 796 NFEKM 800
>gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 78.6 bits (192), Expect = 2e-14
Identities = 53/185 (28%), Positives = 95/185 (51%), Gaps = 4/185 (2%)
Query: 202 DHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPT---MERSIALCNGISQWV 258
D + ++L+ LT ++ F I + +Y++ + T +ER + N + WV
Sbjct: 617 DLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWV 676
Query: 259 QLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPH 318
+ P P RA++ KFI++A L + +N N+ AV+ GL +S+ISRL T +PH
Sbjct: 677 ATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPH 736
Query: 319 EINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKV 378
++ K+ + LL S N+ YR A + + IP + + LKD+ ++E +E+ +
Sbjct: 737 KVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVEN-LI 795
Query: 379 NVHKL 383
N K+
Sbjct: 796 NFEKM 800
>gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a
[Homo sapiens]
Length = 923
Score = 78.6 bits (192), Expect = 2e-14
Identities = 53/185 (28%), Positives = 95/185 (51%), Gaps = 4/185 (2%)
Query: 202 DHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPT---MERSIALCNGISQWV 258
D + ++L+ LT ++ F I + +Y++ + T +ER + N + WV
Sbjct: 659 DLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWV 718
Query: 259 QLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPH 318
+ P P RA++ KFI++A L + +N N+ AV+ GL +S+ISRL T +PH
Sbjct: 719 ATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPH 778
Query: 319 EINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKV 378
++ K+ + LL S N+ YR A + + IP + + LKD+ ++E +E+ +
Sbjct: 779 KVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVEN-LI 837
Query: 379 NVHKL 383
N K+
Sbjct: 838 NFEKM 842
>gi|54633319 PDZ domain-containing guanine nucleotide exchange factor
I [Homo sapiens]
Length = 1601
Score = 76.6 bits (187), Expect = 8e-14
Identities = 65/240 (27%), Positives = 117/240 (48%), Gaps = 13/240 (5%)
Query: 167 RLIDTTQINARDWSRKL--TQRIKSNTS-----KKRKVSLLFDHLEPEELSEHLTYLEFK 219
+L D Q+N R + + T+ + S+ K+ ++S+L L E++ L+ +F
Sbjct: 817 KLADRIQLNGRYYLKNNMETETLCSDEDAQELVKESQLSML--QLSTIEVATQLSMRDFD 874
Query: 220 SFRRISFSDYQNYLVNSCVKENPT-MERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKF 278
FR I ++Y + L K T ++R + N + WV +L+ R ++ F
Sbjct: 875 LFRNIEPTEYIDDLFKLNSKTGNTHLKRFEDIVNQETFWVASEILTEANQLKRMKIIKHF 934
Query: 279 IQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYD 338
I++A + +NFN++ A+I GL +S++RL+ T +P + K L ++ ++ SRN
Sbjct: 935 IKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMA 994
Query: 339 NYRRAYGECTDFK--IPILGVHLKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQL 396
YR + IP+ V KD+ L+E D DG VN KL + I ++V++
Sbjct: 995 KYRNILSSQSMQPPIIPLFPVVKKDMTFLHEG-NDSKVDGLVNFEKLRMISKEIRQVVRM 1053
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,710,232
Number of Sequences: 37866
Number of extensions: 1507858
Number of successful extensions: 6564
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 115
Number of HSP's successfully gapped in prelim test: 70
Number of HSP's that attempted gapping in prelim test: 6193
Number of HSP's gapped (non-prelim): 342
length of query: 797
length of database: 18,247,518
effective HSP length: 110
effective length of query: 687
effective length of database: 14,082,258
effective search space: 9674511246
effective search space used: 9674511246
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.